EGFL7	Q9UHF1	136	190	24	273	Chain	ID=PRO_0000007528;Note=Epidermal growth factor-like protein 7
EGFL7	Q9UHF1	136	190	24	273	Chain	ID=PRO_0000007528;Note=Epidermal growth factor-like protein 7
EGFL7	Q9UHF1	136	190	24	273	Chain	ID=PRO_0000007528;Note=Epidermal growth factor-like protein 7
EGFL7	Q9UHF1	136	190	24	273	Chain	ID=PRO_0000007528;Note=Epidermal growth factor-like protein 7
EGFL7	Q9UHF1	136	190	137	177	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL7	Q9UHF1	136	190	137	177	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL7	Q9UHF1	136	190	137	177	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL7	Q9UHF1	136	190	137	177	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL7	Q9UHF1	136	190	141	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	141	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	141	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	141	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	148	161	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	148	161	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	148	161	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	148	161	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	163	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	163	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	163	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	163	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EGFL7	Q9UHF1	136	190	153	153	Natural variant	ID=VAR_019791;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2297538,PMID:14702039,PMID:15489334
EGFL7	Q9UHF1	136	190	153	153	Natural variant	ID=VAR_019791;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2297538,PMID:14702039,PMID:15489334
EGFL7	Q9UHF1	136	190	153	153	Natural variant	ID=VAR_019791;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2297538,PMID:14702039,PMID:15489334
EGFL7	Q9UHF1	136	190	153	153	Natural variant	ID=VAR_019791;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2297538,PMID:14702039,PMID:15489334
EGFL7	Q9UHF1	136	190	183	183	Natural variant	ID=VAR_048981;Note=P->S;Dbxref=dbSNP:rs35863900
EGFL7	Q9UHF1	136	190	183	183	Natural variant	ID=VAR_048981;Note=P->S;Dbxref=dbSNP:rs35863900
EGFL7	Q9UHF1	136	190	183	183	Natural variant	ID=VAR_048981;Note=P->S;Dbxref=dbSNP:rs35863900
EGFL7	Q9UHF1	136	190	183	183	Natural variant	ID=VAR_048981;Note=P->S;Dbxref=dbSNP:rs35863900
EGFL7	Q9UHF1	136	190	186	186	Natural variant	ID=VAR_048982;Note=A->G;Dbxref=dbSNP:rs34142075
EGFL7	Q9UHF1	136	190	186	186	Natural variant	ID=VAR_048982;Note=A->G;Dbxref=dbSNP:rs34142075
EGFL7	Q9UHF1	136	190	186	186	Natural variant	ID=VAR_048982;Note=A->G;Dbxref=dbSNP:rs34142075
EGFL7	Q9UHF1	136	190	186	186	Natural variant	ID=VAR_048982;Note=A->G;Dbxref=dbSNP:rs34142075
EHBP1L1	Q8N3D4	86	104	1	1523	Chain	ID=PRO_0000285204;Note=EH domain-binding protein 1-like protein 1
EHBP1L1	Q8N3D4	86	104	8	157	Domain	Note=C2 NT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01186
EIF2B3	Q9NR50	325	351	1	452	Chain	ID=PRO_0000156079;Note=Translation initiation factor eIF-2B subunit gamma
EIF2B3	Q9NR50	189	218	1	452	Chain	ID=PRO_0000156079;Note=Translation initiation factor eIF-2B subunit gamma
EIF2B3	Q9NR50	325	351	346	346	Natural variant	ID=VAR_068472;Note=In VWM. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19158808;Dbxref=dbSNP:rs119474039,PMID:19158808
EIF2B3	Q9NR50	189	218	185	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B3	Q9NR50	189	218	191	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B3	Q9NR50	189	218	209	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
GCLC	P48506	399	430	1	637	Chain	ID=PRO_0000192563;Note=Glutamate--cysteine ligase catalytic subunit
GCLC	P48506	251	276	1	637	Chain	ID=PRO_0000192563;Note=Glutamate--cysteine ligase catalytic subunit
GCLC	P48506	149	186	1	637	Chain	ID=PRO_0000192563;Note=Glutamate--cysteine ligase catalytic subunit
GCLC	P48506	149	186	158	158	Natural variant	ID=VAR_015403;Note=In HAGGSD. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10733484;Dbxref=PMID:10733484
GSS	P48637	230	255	2	474	Chain	ID=PRO_0000211260;Note=Glutathione synthetase
GSS	P48637	164	202	2	474	Chain	ID=PRO_0000211260;Note=Glutathione synthetase
GSS	P48637	164	202	93	203	Alternative sequence	ID=VSP_047617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19672693;Dbxref=PMID:19672693
GSS	P48637	164	202	188	188	Natural variant	ID=VAR_003603;Note=In GSS deficiency%3B 100-fold reduction of activity. L->P
GSS	P48637	230	255	236	236	Natural variant	ID=VAR_025047;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs34239729
GSS	P48637	230	255	254	254	Natural variant	ID=VAR_003606;Note=In GSS deficiency. L->R
GSS	P48637	164	202	160	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	164	202	173	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	164	202	184	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	230	255	229	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	230	255	234	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	230	255	239	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	230	255	246	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSS	P48637	230	255	254	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HGS
GSK3B	P49841	365	398	1	420	Chain	ID=PRO_0000085980;Note=Glycogen synthase kinase-3 beta
GSK3B	P49841	271	303	1	420	Chain	ID=PRO_0000085980;Note=Glycogen synthase kinase-3 beta
GSK3B	P49841	122	159	1	420	Chain	ID=PRO_0000085980;Note=Glycogen synthase kinase-3 beta
GSK3B	P49841	94	122	1	420	Chain	ID=PRO_0000085980;Note=Glycogen synthase kinase-3 beta
GSK3B	P49841	271	303	56	340	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GSK3B	P49841	122	159	56	340	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GSK3B	P49841	94	122	56	340	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GSK3B	P49841	365	398	389	389	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WV60
GSK3B	P49841	365	398	390	390	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
GSK3B	P49841	271	303	303	303	Alternative sequence	ID=VSP_004790;Note=In isoform 2. K->KDSSGTGHFTSGVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSK3B	P49841	94	122	96	96	Mutagenesis	Note=Prevents the phosphorylation of phosphate-primed glycogen synthase. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11430833;Dbxref=PMID:11430833
GSK3B	P49841	122	159	128	128	Mutagenesis	Note=Abolishes activity toward AXIN1. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11430833;Dbxref=PMID:11430833
GSK3B	P49841	94	122	96	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	94	122	112	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	122	159	121	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	94	122	121	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	122	159	125	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	122	159	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q5K
GSK3B	P49841	122	159	139	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	122	159	155	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	271	303	262	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	271	303	278	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	271	303	286	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NM3
GSK3B	P49841	271	303	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ACC
GSK3B	P49841	271	303	301	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	365	398	364	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	365	398	371	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	365	398	374	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GSK3B	P49841	365	398	380	383	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J1B
GLG1	Q92896	1012	1048	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	843	889	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	684	705	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	655	684	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	524	557	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	326	350	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	258	326	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	186	258	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	146	157	30	1179	Chain	ID=PRO_0000011120;Note=Golgi apparatus protein 1
GLG1	Q92896	1012	1048	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	843	889	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	684	705	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	655	684	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	524	557	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	326	350	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	258	326	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	186	258	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	146	157	30	1145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	146	157	116	149	Repeat	Note=Cys-rich GLG1 1
GLG1	Q92896	186	258	150	212	Repeat	Note=Cys-rich GLG1 2
GLG1	Q92896	146	157	150	212	Repeat	Note=Cys-rich GLG1 2
GLG1	Q92896	258	326	215	278	Repeat	Note=Cys-rich GLG1 3
GLG1	Q92896	186	258	215	278	Repeat	Note=Cys-rich GLG1 3
GLG1	Q92896	326	350	286	346	Repeat	Note=Cys-rich GLG1 4
GLG1	Q92896	258	326	286	346	Repeat	Note=Cys-rich GLG1 4
GLG1	Q92896	326	350	347	413	Repeat	Note=Cys-rich GLG1 5
GLG1	Q92896	524	557	475	537	Repeat	Note=Cys-rich GLG1 7
GLG1	Q92896	524	557	538	604	Repeat	Note=Cys-rich GLG1 8
GLG1	Q92896	655	684	609	668	Repeat	Note=Cys-rich GLG1 9
GLG1	Q92896	684	705	670	728	Repeat	Note=Cys-rich GLG1 10
GLG1	Q92896	655	684	670	728	Repeat	Note=Cys-rich GLG1 10
GLG1	Q92896	843	889	796	856	Repeat	Note=Cys-rich GLG1 12
GLG1	Q92896	843	889	858	911	Repeat	Note=Cys-rich GLG1 13
GLG1	Q92896	1012	1048	980	1035	Repeat	Note=Cys-rich GLG1 15
GLG1	Q92896	1012	1048	1041	1101	Repeat	Note=Cys-rich GLG1 16
GLG1	Q92896	186	258	210	210	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLG1	Q92896	655	684	677	677	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
GLG1	Q92896	146	157	147	157	Alternative sequence	ID=VSP_043472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLG1	Q92896	524	557	526	526	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLG1	Q92896	684	705	702	702	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GSTA4	O15217	138	182	1	222	Chain	ID=PRO_0000185786;Note=Glutathione S-transferase A4
GSTA4	O15217	138	182	85	208	Domain	Note=GST C-terminal
GSTA4	O15217	138	182	163	163	Natural variant	ID=VAR_022211;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs4147617
GSTA4	O15217	138	182	133	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IK7
GSTA4	O15217	138	182	146	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IK7
GSTA4	O15217	138	182	155	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IK7
GSTA4	O15217	138	182	172	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IK7
GSTA4	O15217	138	182	179	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IK7
GSTT2B	P0CG30	117	175	2	244	Chain	ID=PRO_0000395344;Note=Glutathione S-transferase theta-2B
GSTT2B	P0CG30	117	175	88	224	Domain	Note=GST C-terminal
GSTT2B	P0CG30	117	175	139	139	Natural variant	ID=VAR_033982;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs1622002
GSTT2B	P0CG30	117	175	156	158	Sequence conflict	Note=FLA->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
GSTT2B	P0CG30	117	175	112	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
GSTT2B	P0CG30	117	175	119	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
GSTT2B	P0CG30	117	175	129	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
GSTT2B	P0CG30	117	175	149	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
GSTT2B	P0CG30	117	175	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
GSTT2B	P0CG30	117	175	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
GSTT2B	P0CG30	117	175	164	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MPG
ENTPD8	Q5MY95	350	387	1	495	Chain	ID=PRO_0000306882;Note=Ectonucleoside triphosphate diphosphohydrolase 8
ENTPD8	Q5MY95	350	387	1	495	Chain	ID=PRO_0000306882;Note=Ectonucleoside triphosphate diphosphohydrolase 8
ENTPD8	Q5MY95	350	387	30	471	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD8	Q5MY95	350	387	30	471	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD8	Q5MY95	350	387	363	363	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD8	Q5MY95	350	387	363	363	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD8	Q5MY95	350	387	381	403	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD8	Q5MY95	350	387	381	403	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD8	Q5MY95	350	387	351	387	Alternative sequence	ID=VSP_028559;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ENTPD8	Q5MY95	350	387	351	387	Alternative sequence	ID=VSP_028559;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ENTHD1	Q8IYW4	277	406	1	607	Chain	ID=PRO_0000312179;Note=ENTH domain-containing protein 1
ENTHD1	Q8IYW4	116	197	1	607	Chain	ID=PRO_0000312179;Note=ENTH domain-containing protein 1
ENTHD1	Q8IYW4	116	197	9	141	Domain	Note=ENTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00243
COLGALT1	Q8NBJ5	276	316	30	622	Chain	ID=PRO_0000309536;Note=Procollagen galactosyltransferase 1
COLGALT1	Q8NBJ5	276	316	292	292	Mutagenesis	Note=Small decrease of galactosyltransferase activity. P->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22216269;Dbxref=PMID:22216269
GTF2IRD1	Q9UHL9	88	140	1	959	Chain	ID=PRO_0000083870;Note=General transcription factor II-I repeat domain-containing protein 1
GTF2IRD1	Q9UHL9	335	363	1	959	Chain	ID=PRO_0000083870;Note=General transcription factor II-I repeat domain-containing protein 1
GTF2IRD1	Q9UHL9	509	539	1	959	Chain	ID=PRO_0000083870;Note=General transcription factor II-I repeat domain-containing protein 1
GTF2IRD1	Q9UHL9	539	555	1	959	Chain	ID=PRO_0000083870;Note=General transcription factor II-I repeat domain-containing protein 1
GTF2IRD1	Q9UHL9	655	689	1	959	Chain	ID=PRO_0000083870;Note=General transcription factor II-I repeat domain-containing protein 1
GTF2IRD1	Q9UHL9	689	717	1	959	Chain	ID=PRO_0000083870;Note=General transcription factor II-I repeat domain-containing protein 1
GTF2IRD1	Q9UHL9	88	140	119	213	Repeat	Note=GTF2I-like 1
GTF2IRD1	Q9UHL9	335	363	342	436	Repeat	Note=GTF2I-like 2
GTF2IRD1	Q9UHL9	689	717	696	790	Repeat	Note=GTF2I-like 4
GTF2IRD1	Q9UHL9	88	140	94	94	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GTF2IRD1	Q9UHL9	335	363	337	337	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
GTF2IRD1	Q9UHL9	655	689	684	684	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
GTF2IRD1	Q9UHL9	88	140	89	89	Alternative sequence	ID=VSP_043425;Note=In isoform 3. R->LSAAQHRAATSQLEGRVVRRVLTVASRALCPTG;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
GTF2IRD1	Q9UHL9	655	689	656	670	Alternative sequence	ID=VSP_003873;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10198167,ECO:0000303|PubMed:10575229,ECO:0000303|PubMed:9774679,ECO:0000303|Ref.6;Dbxref=PMID:10198167,PMID:10575229,PMID:9774679
GTF2IRD1	Q9UHL9	88	140	111	111	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
GTF2IRD1	Q9UHL9	88	140	111	111	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
GTF2IRD1	Q9UHL9	88	140	128	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D99
GTF2IRD1	Q9UHL9	689	717	705	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DZR
EPHA4	P54764	629	691	20	986	Chain	ID=PRO_0000016807;Note=Ephrin type-A receptor 4
EPHA4	P54764	326	439	20	986	Chain	ID=PRO_0000016807;Note=Ephrin type-A receptor 4
EPHA4	P54764	274	326	20	986	Chain	ID=PRO_0000016807;Note=Ephrin type-A receptor 4
EPHA4	P54764	629	691	20	986	Chain	ID=PRO_0000016807;Note=Ephrin type-A receptor 4
EPHA4	P54764	326	439	20	986	Chain	ID=PRO_0000016807;Note=Ephrin type-A receptor 4
EPHA4	P54764	274	326	20	986	Chain	ID=PRO_0000016807;Note=Ephrin type-A receptor 4
EPHA4	P54764	326	439	20	547	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	274	326	20	547	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	326	439	20	547	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	274	326	20	547	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	629	691	570	986	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	629	691	570	986	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	326	439	328	439	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
EPHA4	P54764	326	439	328	439	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
EPHA4	P54764	629	691	621	882	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA4	P54764	629	691	621	882	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA4	P54764	629	691	627	635	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA4	P54764	629	691	627	635	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA4	P54764	274	326	191	325	Compositional bias	Note=Cys-rich
EPHA4	P54764	274	326	191	325	Compositional bias	Note=Cys-rich
EPHA4	P54764	629	691	653	653	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA4	P54764	629	691	653	653	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA4	P54764	326	439	340	340	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	326	439	340	340	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	326	439	408	408	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	326	439	408	408	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA4	P54764	326	439	370	370	Natural variant	ID=VAR_042136;Note=In a bladder carcinoma NOS sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs756952113,PMID:17344846
EPHA4	P54764	326	439	370	370	Natural variant	ID=VAR_042136;Note=In a bladder carcinoma NOS sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs756952113,PMID:17344846
EPHA4	P54764	326	439	399	399	Natural variant	ID=VAR_042137;Note=In a metastatic melanoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs868224085,PMID:17344846
EPHA4	P54764	326	439	399	399	Natural variant	ID=VAR_042137;Note=In a metastatic melanoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs868224085,PMID:17344846
EPHA4	P54764	326	439	362	362	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHA4	P54764	326	439	362	362	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHA4	P54764	274	326	272	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	274	326	272	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	274	326	304	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4R
EPHA4	P54764	274	326	304	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4R
EPHA4	P54764	326	439	333	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	333	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	343	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	343	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	361	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	361	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	373	375	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4R
EPHA4	P54764	326	439	373	375	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4R
EPHA4	P54764	326	439	385	388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	385	388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	390	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	390	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	395	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	395	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	405	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	405	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	418	423	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	418	423	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	426	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	426	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	429	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
EPHA4	P54764	326	439	429	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M4P
SLC2A1	P11166	324	358	1	492	Chain	ID=PRO_0000050338;Note=Solute carrier family 2%2C facilitated glucose transporter member 1
SLC2A1	P11166	324	358	307	328	Transmembrane	Note=Helical%3B Name%3D8
SLC2A1	P11166	324	358	329	334	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24847886;Dbxref=PMID:24847886
SLC2A1	P11166	324	358	335	355	Transmembrane	Note=Helical%3B Name%3D9
SLC2A1	P11166	324	358	356	365	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24847886;Dbxref=PMID:24847886
SLC2A1	P11166	324	358	324	324	Natural variant	ID=VAR_065219;Note=In GLUT1DS2%3B mild phenotype%3B reduced transporter activity. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19798636,ECO:0000269|PubMed:20574033;Dbxref=dbSNP:rs796053253,PMID:19798636,PMID:20574033
SLC2A1	P11166	324	358	329	329	Natural variant	ID=VAR_065220;Note=In GLUT1DS1%3B stabilizes the inward-open conformation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20129935;Dbxref=PMID:20129935
SLC2A1	P11166	324	358	333	333	Natural variant	ID=VAR_065221;Note=In GLUT1DS1 and GLUT1DS2. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19630075,ECO:0000269|PubMed:20129935;Dbxref=PMID:19630075,PMID:20129935
SLC2A1	P11166	324	358	333	333	Natural variant	ID=VAR_013286;Note=In GLUT1DS1%3B 43%25 of wild-type glucose uptake activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10980529,ECO:0000269|PubMed:12325075,ECO:0000269|PubMed:15622525;Dbxref=dbSNP:rs80359825,PMID:10980529,PMID:12325075,PMID:15622525
SLC2A1	P11166	324	358	340	340	Mutagenesis	Note=Strongly decreases glucose transport. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19449892;Dbxref=PMID:19449892
SLC2A1	P11166	324	358	306	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EQG
SLC2A1	P11166	324	358	333	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EQG
SLC2A1	P11166	324	358	357	360	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EQG
SLC2A2	P11168	390	458	1	524	Chain	ID=PRO_0000050346;Note=Solute carrier family 2%2C facilitated glucose transporter member 2
SLC2A2	P11168	390	458	390	400	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A2	P11168	390	458	401	421	Transmembrane	Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A2	P11168	390	458	422	433	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A2	P11168	390	458	434	454	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A2	P11168	390	458	455	461	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A2	P11168	390	458	420	420	Binding site	Note=Monosaccharide;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC2A2	P11168	390	458	404	404	Natural variant	ID=VAR_052501;Note=I->T;Dbxref=dbSNP:rs2229608
SLC2A2	P11168	390	458	417	417	Natural variant	ID=VAR_018652;Note=In FBS. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10987651;Dbxref=dbSNP:rs121909744,PMID:10987651
SLC2A2	P11168	390	458	423	423	Natural variant	ID=VAR_018653;Note=In FBS. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11044475;Dbxref=dbSNP:rs28928874,PMID:11044475
SLC2A9	Q9NRM0	371	405	1	540	Chain	ID=PRO_0000050378;Note=Solute carrier family 2%2C facilitated glucose transporter member 9
SLC2A9	Q9NRM0	334	371	1	540	Chain	ID=PRO_0000050378;Note=Solute carrier family 2%2C facilitated glucose transporter member 9
SLC2A9	Q9NRM0	50	83	1	540	Chain	ID=PRO_0000050378;Note=Solute carrier family 2%2C facilitated glucose transporter member 9
SLC2A9	Q9NRM0	50	83	1	51	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	50	83	52	72	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	50	83	73	107	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	334	371	317	337	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	334	371	338	354	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	371	405	355	375	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	334	371	355	375	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	371	405	376	381	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	371	405	382	402	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	371	405	403	415	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A9	Q9NRM0	50	83	1	50	Alternative sequence	ID=VSP_034860;Note=In isoform 2. MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRK->MKLSKKDRGEDEESDSAKKKL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC2A9	Q9NRM0	50	83	75	75	Natural variant	ID=VAR_065772;Note=In RHUC2%3B reduced urate transport activity. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19926891;Dbxref=dbSNP:rs863225072,PMID:19926891
SLC2A9	Q9NRM0	334	371	350	350	Natural variant	ID=VAR_012159;Note=Polymorphism%3B no effect on urate transport activity. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10860667,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:18327256,ECO:0000269|PubMed:25268603;Dbxref=dbSNP:rs2280205,PMID:10860667,PMID:15489334,PMID:18327256,PMID:25268603
SLC2A9	Q9NRM0	371	405	380	380	Natural variant	ID=VAR_065776;Note=In RHUC2%3B markedly reduced urate transport activity. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19026395;Dbxref=dbSNP:rs121908321,PMID:19026395
EQTN	Q9NQ60	96	125	15	294	Chain	ID=PRO_0000286593;Note=Equatorin
EQTN	Q9NQ60	96	125	15	181	Topological domain	Note=Vesicular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EQTN	Q9NQ60	96	125	97	126	Alternative sequence	ID=VSP_042157;Note=In isoform 3. DKTVNATTYEKSTIEEETTTSEPSHKNIQR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EQTN	Q9NQ60	96	125	101	101	Natural variant	ID=VAR_032136;Note=N->D;Dbxref=dbSNP:rs12337286
EQTN	Q9NQ60	96	125	110	110	Natural variant	ID=VAR_056727;Note=I->T;Dbxref=dbSNP:rs12341576
EPN1	Q9Y6I3	507	593	1	576	Chain	ID=PRO_0000074513;Note=Epsin-1
EPN1	Q9Y6I3	507	593	518	520	Repeat	Note=2
EPN1	Q9Y6I3	507	593	572	574	Repeat	Note=3
EPN1	Q9Y6I3	507	593	502	574	Region	Note=3 X 3 AA repeats of N-P-F
EPN1	Q9Y6I3	507	593	267	573	Compositional bias	Note=Ala/Gly/Pro-rich
EPN1	Q9Y6I3	507	593	534	534	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80VP1
ERAP1	Q9NZ08	762	815	1	941	Chain	ID=PRO_0000026751;Note=Endoplasmic reticulum aminopeptidase 1
ERAP1	Q9NZ08	221	266	1	941	Chain	ID=PRO_0000026751;Note=Endoplasmic reticulum aminopeptidase 1
ERAP1	Q9NZ08	762	815	22	941	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAP1	Q9NZ08	221	266	22	941	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAP1	Q9NZ08	221	266	221	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD0
ERAP1	Q9NZ08	221	266	231	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD0
ERAP1	Q9NZ08	221	266	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD0
ERAP1	Q9NZ08	221	266	249	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD0
ERAP1	Q9NZ08	221	266	255	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD0
ERAP1	Q9NZ08	221	266	266	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD0
ERAP1	Q9NZ08	762	815	765	767	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RJO
ERAP1	Q9NZ08	762	815	768	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RJO
ERAP1	Q9NZ08	762	815	779	791	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RJO
ERAP1	Q9NZ08	762	815	795	805	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RJO
ERAP1	Q9NZ08	762	815	811	823	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RJO
EPO	P01588	53	82	28	193	Chain	ID=PRO_0000008401;Note=Erythropoietin
EPO	P01588	82	142	28	193	Chain	ID=PRO_0000008401;Note=Erythropoietin
EPO	P01588	53	82	65	65	Glycosylation	ID=CAR_000166;Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763
EPO	P01588	82	142	110	110	Glycosylation	ID=CAR_000192;Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763
EPO	P01588	53	82	34	188	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763
EPO	P01588	82	142	34	188	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763
EPO	P01588	53	82	56	60	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763
EPO	P01588	53	82	70	70	Natural variant	ID=VAR_080573;Note=In ECYT5%3B unknown pathological significance. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=PMID:27651169
EPO	P01588	82	142	84	84	Natural variant	ID=VAR_080574;Note=In ECYT5%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=PMID:27651169
EPO	P01588	82	142	99	99	Natural variant	ID=VAR_080575;Note=Found in a patient thought to have erythrocytosis%2C but had normal red cell mass%3B unknown pathological significance. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=PMID:27651169
EPO	P01588	82	142	114	114	Natural variant	ID=VAR_080576;Note=In ECYT5%3B unknown pathological significance. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=PMID:27651169
EPO	P01588	82	142	131	132	Natural variant	ID=VAR_009870;Note=In a hepatocellular carcinoma. SL->NF
EPO	P01588	82	142	127	127	Mutagenesis	Note=Decreased erythrocyte proliferation%3B impaired EPOR dimerization following binding. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28283061;Dbxref=PMID:28283061
EPO	P01588	82	142	85	85	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPO	P01588	82	142	140	140	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPO	P01588	53	82	53	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EER
EPO	P01588	53	82	57	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BUY
EPO	P01588	53	82	61	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EER
EPO	P01588	53	82	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EER
EPO	P01588	53	82	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BUY
EPO	P01588	82	142	83	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EER
EPO	P01588	82	142	118	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EER
EPO	P01588	82	142	141	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EER
ERCC2	P18074	159	198	1	760	Chain	ID=PRO_0000101980;Note=General transcription and DNA repair factor IIH helicase subunit XPD
ERCC2	P18074	82	120	1	760	Chain	ID=PRO_0000101980;Note=General transcription and DNA repair factor IIH helicase subunit XPD
ERCC2	P18074	35	61	1	760	Chain	ID=PRO_0000101980;Note=General transcription and DNA repair factor IIH helicase subunit XPD
ERCC2	P18074	159	198	7	283	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ERCC2	P18074	82	120	7	283	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ERCC2	P18074	35	61	7	283	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ERCC2	P18074	35	61	42	49	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ERCC2	P18074	82	120	116	116	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
ERCC2	P18074	159	198	190	190	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000305;evidence=ECO:0000305
ERCC2	P18074	35	61	47	47	Natural variant	ID=VAR_008187;Note=In XP-D. G->R
ERCC2	P18074	82	120	112	112	Natural variant	ID=VAR_003622;Note=In TTD1 and XP-D. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11709541,ECO:0000269|PubMed:7920640,ECO:0000269|PubMed:9758621;Dbxref=dbSNP:rs121913020,PMID:11709541,PMID:7920640,PMID:9758621
ERCC2	P18074	35	61	48	48	Mutagenesis	Note=Decreased transcriptional activity of the reconstituted TFIIH complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10024882;Dbxref=PMID:10024882
ERCC2	P18074	159	198	190	190	Mutagenesis	Note=Reduced iron-sulfur-binding. Iron-sulfur-binding is further decreased in absence of MMS19. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678361;Dbxref=PMID:22678361
TM7SF2	O76062	101	166	1	418	Chain	ID=PRO_0000207500;Note=Delta(14)-sterol reductase
TM7SF2	O76062	297	324	1	418	Chain	ID=PRO_0000207500;Note=Delta(14)-sterol reductase
TM7SF2	O76062	324	365	1	418	Chain	ID=PRO_0000207500;Note=Delta(14)-sterol reductase
TM7SF2	O76062	101	166	102	124	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF2	O76062	101	166	129	148	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF2	O76062	297	324	287	304	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF2	O76062	324	365	355	377	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF2	O76062	324	365	350	351	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G4SW86
TM7SF2	O76062	297	324	311	311	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G4SW86
TM7SF2	O76062	297	324	315	315	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G4SW86
TM7SF2	O76062	324	365	338	338	Binding site	Note=NADP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G4SW86
TM7SF2	O76062	324	365	343	343	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G4SW86
TM7SF2	O76062	297	324	298	324	Alternative sequence	ID=VSP_017898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TM7SF2	O76062	324	365	298	324	Alternative sequence	ID=VSP_017898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TM7SF2	O76062	101	166	119	119	Natural variant	ID=VAR_052153;Note=A->V;Dbxref=dbSNP:rs11539360
TM7SF2	O76062	297	324	299	299	Natural variant	ID=VAR_012716;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9615229,ECO:0000269|PubMed:9878250;Dbxref=dbSNP:rs1129195,PMID:14702039,PMID:15489334,PMID:9615229,PMID:9878250
EHD2	Q9NZN4	305	360	1	543	Chain	ID=PRO_0000146111;Note=EH domain-containing protein 2
EHD2	Q9NZN4	305	360	320	340	Region	Note=Mediates membrane-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BH64
EHMT1	Q9H9B1	390	416	2	1298	Chain	ID=PRO_0000186067;Note=Histone-lysine N-methyltransferase EHMT1
EHMT1	Q9H9B1	456	500	2	1298	Chain	ID=PRO_0000186067;Note=Histone-lysine N-methyltransferase EHMT1
EHMT1	Q9H9B1	549	597	2	1298	Chain	ID=PRO_0000186067;Note=Histone-lysine N-methyltransferase EHMT1
EHMT1	Q9H9B1	794	835	2	1298	Chain	ID=PRO_0000186067;Note=Histone-lysine N-methyltransferase EHMT1
EHMT1	Q9H9B1	956	1011	2	1298	Chain	ID=PRO_0000186067;Note=Histone-lysine N-methyltransferase EHMT1
EHMT1	Q9H9B1	1060	1086	2	1298	Chain	ID=PRO_0000186067;Note=Histone-lysine N-methyltransferase EHMT1
EHMT1	Q9H9B1	794	835	772	801	Repeat	Note=ANK 2
EHMT1	Q9H9B1	794	835	805	834	Repeat	Note=ANK 3
EHMT1	Q9H9B1	956	1011	938	967	Repeat	Note=ANK 7
EHMT1	Q9H9B1	956	1011	971	1004	Repeat	Note=ANK 8
EHMT1	Q9H9B1	1060	1086	1060	1123	Domain	Note=Pre-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00157
EHMT1	Q9H9B1	390	416	406	409	Compositional bias	Note=Poly-Glu
EHMT1	Q9H9B1	1060	1086	1062	1062	Metal binding	Note=Zinc 1
EHMT1	Q9H9B1	1060	1086	1062	1062	Metal binding	Note=Zinc 2
EHMT1	Q9H9B1	1060	1086	1064	1064	Metal binding	Note=Zinc 1
EHMT1	Q9H9B1	1060	1086	1068	1068	Metal binding	Note=Zinc 1
EHMT1	Q9H9B1	1060	1086	1068	1068	Metal binding	Note=Zinc 3
EHMT1	Q9H9B1	1060	1086	1073	1073	Metal binding	Note=Zinc 1
EHMT1	Q9H9B1	1060	1086	1075	1075	Metal binding	Note=Zinc 2
EHMT1	Q9H9B1	456	500	483	483	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
EHMT1	Q9H9B1	956	1011	1004	1004	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EHMT1	Q9H9B1	456	500	492	492	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EHMT1	Q9H9B1	549	597	559	559	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EHMT1	Q9H9B1	390	416	67	1298	Alternative sequence	ID=VSP_002223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EHMT1	Q9H9B1	456	500	67	1298	Alternative sequence	ID=VSP_002223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EHMT1	Q9H9B1	549	597	67	1298	Alternative sequence	ID=VSP_002223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EHMT1	Q9H9B1	794	835	67	1298	Alternative sequence	ID=VSP_002223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EHMT1	Q9H9B1	956	1011	67	1298	Alternative sequence	ID=VSP_002223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EHMT1	Q9H9B1	1060	1086	67	1298	Alternative sequence	ID=VSP_002223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EHMT1	Q9H9B1	794	835	795	808	Alternative sequence	ID=VSP_040717;Note=In isoform 4. AGANIDTCSEDQRT->FCRLGSPRSRGCLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EHMT1	Q9H9B1	794	835	809	1298	Alternative sequence	ID=VSP_040718;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EHMT1	Q9H9B1	956	1011	809	1298	Alternative sequence	ID=VSP_040718;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EHMT1	Q9H9B1	1060	1086	809	1298	Alternative sequence	ID=VSP_040718;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EHMT1	Q9H9B1	1060	1086	1075	1075	Natural variant	ID=VAR_069183;Note=In KLEFS1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19264732;Dbxref=PMID:19264732
EHMT1	Q9H9B1	549	597	555	555	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHMT1	Q9H9B1	549	597	561	561	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHMT1	Q9H9B1	549	597	561	561	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHMT1	Q9H9B1	794	835	786	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BY9
EHMT1	Q9H9B1	794	835	809	815	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BY9
EHMT1	Q9H9B1	794	835	819	828	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BY9
EHMT1	Q9H9B1	956	1011	952	960	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BY9
EHMT1	Q9H9B1	956	1011	970	972	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BY9
EHMT1	Q9H9B1	956	1011	975	978	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BY9
EHMT1	Q9H9B1	956	1011	983	994	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNA
EHMT1	Q9H9B1	956	1011	1008	1012	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNA
EHMT1	Q9H9B1	1060	1086	1065	1068	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNA
EHMT1	Q9H9B1	1060	1086	1074	1078	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNA
ETNK1	Q9HBU6	322	350	1	452	Chain	ID=PRO_0000206227;Note=Ethanolamine kinase 1
ETNK1	Q9HBU6	322	350	228	452	Alternative sequence	ID=VSP_047191;Note=In isoform 2. RLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIPSSQILQEEMTWMKEILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQSQWLRAYLEAYKEFKGFGTEVTEKEVEILFIQVNQFALASHFFWGLWALIQAKYSTIEFDFLGYAIVRFNQYFKMKPEVTALKVPE->SLSSLTLCKGKTTRCFGLTGCRGSRLLLSFF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ELF2	Q15723	163	192	1	593	Chain	ID=PRO_0000204087;Note=ETS-related transcription factor Elf-2
ELF2	Q15723	163	192	182	182	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHC9
ELF2	Q15723	163	192	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
ELF2	Q15723	163	192	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
ELF2	Q15723	163	192	175	203	Alternative sequence	ID=VSP_014156;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ELMO1	Q92556	571	607	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	362	397	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	260	277	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	138	149	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	64	81	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	571	607	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	362	397	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	260	277	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	138	149	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	64	81	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	571	607	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	362	397	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	260	277	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	138	149	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	64	81	1	727	Chain	ID=PRO_0000153712;Note=Engulfment and cell motility protein 1
ELMO1	Q92556	362	397	319	492	Domain	Note=ELMO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00664
ELMO1	Q92556	362	397	319	492	Domain	Note=ELMO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00664
ELMO1	Q92556	362	397	319	492	Domain	Note=ELMO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00664
ELMO1	Q92556	571	607	555	676	Domain	Note=PH
ELMO1	Q92556	571	607	555	676	Domain	Note=PH
ELMO1	Q92556	571	607	555	676	Domain	Note=PH
ELMO1	Q92556	362	397	395	395	Modified residue	Note=Phosphotyrosine%3B by HCK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15952790;Dbxref=PMID:15952790
ELMO1	Q92556	362	397	395	395	Modified residue	Note=Phosphotyrosine%3B by HCK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15952790;Dbxref=PMID:15952790
ELMO1	Q92556	362	397	395	395	Modified residue	Note=Phosphotyrosine%3B by HCK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15952790;Dbxref=PMID:15952790
ELMO1	Q92556	362	397	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	260	277	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	138	149	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	64	81	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	362	397	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	260	277	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	138	149	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	64	81	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	362	397	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	260	277	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	138	149	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	64	81	1	480	Alternative sequence	ID=VSP_007480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9179496;Dbxref=PMID:15489334,PMID:9179496
ELMO1	Q92556	260	277	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	138	149	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	64	81	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	260	277	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	138	149	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	64	81	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	260	277	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	138	149	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	64	81	1	298	Alternative sequence	ID=VSP_038550;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	362	397	299	362	Alternative sequence	ID=VSP_038551;Note=In isoform 3. VLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFI->MSEHQKEQTLDTPSLRTVTLTVRVHGFILEVSKTKNPPIPDTFWPPRWDHRPSPGGETNAYCQM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	362	397	299	362	Alternative sequence	ID=VSP_038551;Note=In isoform 3. VLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFI->MSEHQKEQTLDTPSLRTVTLTVRVHGFILEVSKTKNPPIPDTFWPPRWDHRPSPGGETNAYCQM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	362	397	299	362	Alternative sequence	ID=VSP_038551;Note=In isoform 3. VLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFI->MSEHQKEQTLDTPSLRTVTLTVRVHGFILEVSKTKNPPIPDTFWPPRWDHRPSPGGETNAYCQM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELMO1	Q92556	362	397	362	362	Natural variant	ID=VAR_065824;Note=I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20869035;Dbxref=PMID:20869035
ELMO1	Q92556	362	397	362	362	Natural variant	ID=VAR_065824;Note=I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20869035;Dbxref=PMID:20869035
ELMO1	Q92556	362	397	362	362	Natural variant	ID=VAR_065824;Note=I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20869035;Dbxref=PMID:20869035
ELMO1	Q92556	571	607	569	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSZ
ELMO1	Q92556	571	607	569	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSZ
ELMO1	Q92556	571	607	569	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSZ
ELMO1	Q92556	571	607	573	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	573	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	573	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	583	590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	583	590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	583	590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	607	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	607	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
ELMO1	Q92556	571	607	607	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A98
MPP1	Q00013	261	288	2	466	Chain	ID=PRO_0000094565;Note=55 kDa erythrocyte membrane protein
MPP1	Q00013	137	160	2	466	Chain	ID=PRO_0000094565;Note=55 kDa erythrocyte membrane protein
MPP1	Q00013	137	160	71	152	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
MPP1	Q00013	137	160	158	228	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
MPP1	Q00013	261	288	282	451	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP1	Q00013	261	288	268	466	Region	Note=Interaction with MPP5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17584769;Dbxref=PMID:17584769
MPP1	Q00013	137	160	131	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJY
MPP1	Q00013	137	160	142	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJY
MPP1	Q00013	261	288	284	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NEY
EML3	Q32P44	594	638	1	896	Chain	ID=PRO_0000284390;Note=Echinoderm microtubule-associated protein-like 3
EML3	Q32P44	552	594	1	896	Chain	ID=PRO_0000284390;Note=Echinoderm microtubule-associated protein-like 3
EML3	Q32P44	402	454	1	896	Chain	ID=PRO_0000284390;Note=Echinoderm microtubule-associated protein-like 3
EML3	Q32P44	402	454	398	434	Repeat	Note=WD 4
EML3	Q32P44	402	454	448	487	Repeat	Note=WD 5
EML3	Q32P44	552	594	549	584	Repeat	Note=WD 7
EML3	Q32P44	594	638	589	626	Repeat	Note=WD 8
EML3	Q32P44	552	594	589	626	Repeat	Note=WD 8
EML3	Q32P44	594	638	629	667	Repeat	Note=WD 9
EML3	Q32P44	594	638	224	896	Alternative sequence	ID=VSP_039928;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EML3	Q32P44	552	594	224	896	Alternative sequence	ID=VSP_039928;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EML3	Q32P44	402	454	224	896	Alternative sequence	ID=VSP_039928;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EML3	Q32P44	594	638	620	620	Natural variant	ID=VAR_031725;Note=Q->K;Dbxref=dbSNP:rs34098002
EML5	Q05BV3	1444	1502	1	1969	Chain	ID=PRO_0000284395;Note=Echinoderm microtubule-associated protein-like 5
EML5	Q05BV3	552	608	1	1969	Chain	ID=PRO_0000284395;Note=Echinoderm microtubule-associated protein-like 5
EML5	Q05BV3	552	608	561	601	Repeat	Note=WD 10
EML5	Q05BV3	1444	1502	1412	1463	Repeat	Note=WD 20
EML5	Q05BV3	1444	1502	1467	1508	Repeat	Note=WD 21
EML5	Q05BV3	1444	1502	623	1969	Alternative sequence	ID=VSP_041259;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EML5	Q05BV3	1444	1502	1145	1969	Alternative sequence	ID=VSP_041261;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EMC1	Q8N766	688	734	22	993	Chain	ID=PRO_0000248597;Note=ER membrane protein complex subunit 1
EMC1	Q8N766	594	648	22	993	Chain	ID=PRO_0000248597;Note=ER membrane protein complex subunit 1
EMC1	Q8N766	544	594	22	993	Chain	ID=PRO_0000248597;Note=ER membrane protein complex subunit 1
EMC1	Q8N766	436	477	22	993	Chain	ID=PRO_0000248597;Note=ER membrane protein complex subunit 1
EMC1	Q8N766	342	363	22	993	Chain	ID=PRO_0000248597;Note=ER membrane protein complex subunit 1
EMC1	Q8N766	73	95	22	993	Chain	ID=PRO_0000248597;Note=ER membrane protein complex subunit 1
EMC1	Q8N766	688	734	22	958	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC1	Q8N766	594	648	22	958	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC1	Q8N766	544	594	22	958	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC1	Q8N766	436	477	22	958	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC1	Q8N766	342	363	22	958	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC1	Q8N766	73	95	22	958	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC1	Q8N766	73	95	74	96	Alternative sequence	ID=VSP_020327;Note=In isoform 4. LWRHVDKGTAEGAVDAMLLHGQD->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
EMC1	Q8N766	342	363	343	343	Alternative sequence	ID=VSP_020328;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7788527;Dbxref=PMID:7788527
EMC1	Q8N766	436	477	437	437	Alternative sequence	ID=VSP_020329;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EMC1	Q8N766	73	95	82	82	Natural variant	ID=VAR_076915;Note=In CAVIPMR. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26942288;Dbxref=dbSNP:rs869320625,PMID:26942288
EMC1	Q8N766	342	363	345	345	Natural variant	ID=VAR_027360;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs709683,PMID:14702039,PMID:16303743
EMC1	Q8N766	342	363	347	347	Natural variant	ID=VAR_027361;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs709682,PMID:16303743
EMC1	Q8N766	436	477	471	471	Natural variant	ID=VAR_076917;Note=In CAVIPMR%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26942288;Dbxref=dbSNP:rs879253819,PMID:26942288
EMC1	Q8N766	436	477	469	469	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMC1	Q8N766	544	594	570	570	Sequence conflict	Note=F->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMC1	Q8N766	688	734	724	724	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EME2	A4GXA9	128	159	1	379	Chain	ID=PRO_0000317373;Note=Probable crossover junction endonuclease EME2
EME2	A4GXA9	128	159	1	134	Alternative sequence	ID=VSP_030938;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
EME2	A4GXA9	128	159	135	190	Alternative sequence	ID=VSP_030939;Note=In isoform 2. AAGEQELLLLLEPEEFLQGVATLTQISGPTHWVPWISPETTARPHLAVIGLDAYLW->MPTAGLAGTGVQGRWAHFWGCCGTADPTSPGGLWQRPSSGRAGPMGSGEEWSPLLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
ELMSAN1	Q6PJG2	908	979	1	1045	Chain	ID=PRO_0000259764;Note=ELM2 and SANT domain-containing protein 1
ELMSAN1	Q6PJG2	858	908	1	1045	Chain	ID=PRO_0000259764;Note=ELM2 and SANT domain-containing protein 1
ELMSAN1	Q6PJG2	483	583	1	1045	Chain	ID=PRO_0000259764;Note=ELM2 and SANT domain-containing protein 1
ELMSAN1	Q6PJG2	908	979	1	1045	Chain	ID=PRO_0000259764;Note=ELM2 and SANT domain-containing protein 1
ELMSAN1	Q6PJG2	858	908	1	1045	Chain	ID=PRO_0000259764;Note=ELM2 and SANT domain-containing protein 1
ELMSAN1	Q6PJG2	483	583	1	1045	Chain	ID=PRO_0000259764;Note=ELM2 and SANT domain-containing protein 1
ELMSAN1	Q6PJG2	858	908	828	879	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
ELMSAN1	Q6PJG2	858	908	828	879	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
ELMSAN1	Q6PJG2	908	979	923	923	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ELMSAN1	Q6PJG2	908	979	923	923	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ELMSAN1	Q6PJG2	483	583	554	554	Natural variant	ID=VAR_050183;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17782124,PMID:15489334
ELMSAN1	Q6PJG2	483	583	554	554	Natural variant	ID=VAR_050183;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17782124,PMID:15489334
ELMSAN1	Q6PJG2	858	908	895	895	Natural variant	ID=VAR_061361;Note=D->N;Dbxref=dbSNP:rs35905570
ELMSAN1	Q6PJG2	858	908	895	895	Natural variant	ID=VAR_061361;Note=D->N;Dbxref=dbSNP:rs35905570
ENDOU	P21128	18	59	1	18	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2350438;Dbxref=PMID:2350438
ENDOU	P21128	18	59	19	410	Chain	ID=PRO_0000036405;Note=Poly(U)-specific endoribonuclease
ENDOU	P21128	18	59	20	62	Domain	Note=SMB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	24	40	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	24	28	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	28	58	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	38	51	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	38	40	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	44	50	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	51	58	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENDOU	P21128	18	59	19	82	Alternative sequence	ID=VSP_039215;Note=In isoform 3. GKIESCASRCNEKFNRDAACQCDRRCLWHGNCCEDYEHLCTEDHKESEPLPQLEEETEEALASN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ENDOU	P21128	18	59	19	59	Alternative sequence	ID=VSP_039216;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2350438;Dbxref=PMID:14702039,PMID:15489334,PMID:2350438
ENDOV	Q8N8Q3	76	121	1	282	Chain	ID=PRO_0000349223;Note=Endonuclease V
ENDOV	Q8N8Q3	172	195	1	282	Chain	ID=PRO_0000349223;Note=Endonuclease V
ENDOV	Q8N8Q3	195	238	1	282	Chain	ID=PRO_0000349223;Note=Endonuclease V
ENDOV	Q8N8Q3	195	238	225	228	Compositional bias	Note=Poly-Cys
ENDOV	Q8N8Q3	76	121	91	91	Site	Note=Interaction with target RNA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENDOV	Q8N8Q3	76	121	1	194	Alternative sequence	ID=VSP_035228;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ENDOV	Q8N8Q3	172	195	1	194	Alternative sequence	ID=VSP_035228;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ENDOV	Q8N8Q3	76	121	77	121	Alternative sequence	ID=VSP_035229;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ENDOV	Q8N8Q3	76	121	112	112	Natural variant	ID=VAR_046286;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34933300
ENDOV	Q8N8Q3	76	121	114	114	Natural variant	ID=VAR_046287;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs41298706
ENDOV	Q8N8Q3	195	238	201	201	Natural variant	ID=VAR_046289;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs35929621
ENDOV	Q8N8Q3	76	121	90	93	Mutagenesis	Note=Abolishes ability to bind branched DNA and RNA. PYVS->GGGG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23912683;Dbxref=PMID:23912683
ENDOV	Q8N8Q3	76	121	91	91	Mutagenesis	Note=Abolishes ribonuclease activity without affecting ability to bind branched DNA. Y->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23912683,ECO:0000269|PubMed:23912718;Dbxref=PMID:23912683,PMID:23912718
ENDOV	Q8N8Q3	76	121	100	100	Mutagenesis	Note=Abolishes ribonuclease activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23912718;Dbxref=PMID:23912718
ENDOV	Q8N8Q3	76	121	77	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	76	121	97	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	76	121	116	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	76	121	121	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	172	195	167	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	172	195	182	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	172	195	192	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	195	238	192	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	195	238	207	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	195	238	217	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	195	238	229	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENDOV	Q8N8Q3	195	238	234	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSP
ENTPD2	Q9Y5L3	383	428	1	495	Chain	ID=PRO_0000209906;Note=Ectonucleoside triphosphate diphosphohydrolase 2
ENTPD2	Q9Y5L3	258	343	1	495	Chain	ID=PRO_0000209906;Note=Ectonucleoside triphosphate diphosphohydrolase 2
ENTPD2	Q9Y5L3	383	428	29	462	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD2	Q9Y5L3	258	343	29	462	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD2	Q9Y5L3	258	343	294	294	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD2	Q9Y5L3	258	343	242	284	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD2	Q9Y5L3	258	343	265	310	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD2	Q9Y5L3	258	343	323	328	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD2	Q9Y5L3	383	428	377	399	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD2	Q9Y5L3	383	428	383	405	Alternative sequence	ID=VSP_003610;Note=In isoform Short and isoform gamma. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9271669;Dbxref=PMID:9271669
ENTPD2	Q9Y5L3	383	428	406	428	Alternative sequence	ID=VSP_053548;Note=In isoform gamma. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENTPD2	Q9Y5L3	383	428	399	399	Mutagenesis	Note=Abolishes ecto-ATPase activity%2C accumulates intracellularly. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12888562;Dbxref=PMID:12888562
EPS15L1	Q9UBC2	542	597	2	864	Chain	ID=PRO_0000146118;Note=Epidermal growth factor receptor substrate 15-like 1
EPS15L1	Q9UBC2	422	476	2	864	Chain	ID=PRO_0000146118;Note=Epidermal growth factor receptor substrate 15-like 1
EPS15L1	Q9UBC2	186	264	2	864	Chain	ID=PRO_0000146118;Note=Epidermal growth factor receptor substrate 15-like 1
EPS15L1	Q9UBC2	71	103	2	864	Chain	ID=PRO_0000146118;Note=Epidermal growth factor receptor substrate 15-like 1
EPS15L1	Q9UBC2	55	71	2	864	Chain	ID=PRO_0000146118;Note=Epidermal growth factor receptor substrate 15-like 1
EPS15L1	Q9UBC2	71	103	15	104	Domain	Note=EH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15L1	Q9UBC2	55	71	15	104	Domain	Note=EH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15L1	Q9UBC2	186	264	127	215	Domain	Note=EH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15L1	Q9UBC2	186	264	159	194	Domain	Note=EF-hand;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EPS15L1	Q9UBC2	186	264	15	368	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15L1	Q9UBC2	71	103	15	368	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15L1	Q9UBC2	55	71	15	368	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15L1	Q9UBC2	542	597	386	553	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EPS15L1	Q9UBC2	422	476	386	553	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EPS15L1	Q9UBC2	71	103	74	74	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60902
EPS15L1	Q9UBC2	186	264	229	229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:23186163,PMID:24275569
EPS15L1	Q9UBC2	186	264	244	244	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
EPS15L1	Q9UBC2	186	264	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPS15L1	Q9UBC2	186	264	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
EPS15L1	Q9UBC2	186	264	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPS15L1	Q9UBC2	542	597	560	560	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
EPS15L1	Q9UBC2	542	597	564	564	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60902
EPS15L1	Q9UBC2	542	597	577	577	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
EPS15L1	Q9UBC2	542	597	593	593	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EPHA3	P29320	897	948	21	983	Chain	ID=PRO_0000016802;Note=Ephrin type-A receptor 3
EPHA3	P29320	897	948	566	983	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA3	P29320	897	948	911	975	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
EPHA3	P29320	897	948	937	937	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29319
EPHA3	P29320	897	948	540	983	Alternative sequence	ID=VSP_002996;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10987298;Dbxref=PMID:10987298
EPHA3	P29320	897	948	914	914	Natural variant	ID=VAR_027919;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs17801309,PMID:17344846
EPHA3	P29320	897	948	924	924	Natural variant	ID=VAR_042134;Note=W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1311845,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35124509,PMID:1311845,PMID:17344846
EPHA3	P29320	897	948	933	933	Natural variant	ID=VAR_065832;Note=In a lung carcinoma sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16941478;Dbxref=dbSNP:rs372594677,PMID:16941478
EPHA3	P29320	897	948	911	911	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHA3	P29320	897	948	898	903	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QOC
EPG5	Q9HCE0	1128	1194	1	2579	Chain	ID=PRO_0000306255;Note=Ectopic P granules protein 5 homolog
EPG5	Q9HCE0	1033	1079	1	2579	Chain	ID=PRO_0000306255;Note=Ectopic P granules protein 5 homolog
EPG5	Q9HCE0	1033	1079	1058	1058	Natural variant	ID=VAR_035279;Note=V->A;Dbxref=dbSNP:rs3744998
EPG5	Q9HCE0	1128	1194	1131	1131	Natural variant	ID=VAR_035280;Note=I->V;Dbxref=dbSNP:rs3744997
EPGN	Q6UW88	85	135	23	154	Chain	ID=PRO_0000045462;Note=Epigen
EPGN	Q6UW88	85	135	23	110	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPGN	Q6UW88	85	135	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPGN	Q6UW88	85	135	132	154	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPGN	Q6UW88	85	135	56	96	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EPGN	Q6UW88	85	135	86	95	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EPGN	Q6UW88	85	135	87	137	Alternative sequence	ID=VSP_036656;Note=In isoform 4%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
EPGN	Q6UW88	85	135	96	137	Alternative sequence	ID=VSP_036657;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
EPGN	Q6UW88	85	135	92	95	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WB8
EPHA5	P54756	597	618	25	1037	Chain	ID=PRO_0000016812;Note=Ephrin type-A receptor 5
EPHA5	P54756	355	467	25	1037	Chain	ID=PRO_0000016812;Note=Ephrin type-A receptor 5
EPHA5	P54756	303	355	25	1037	Chain	ID=PRO_0000016812;Note=Ephrin type-A receptor 5
EPHA5	P54756	355	467	25	573	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	303	355	25	573	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	597	618	595	1037	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	355	467	357	467	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
EPHA5	P54756	303	355	220	354	Compositional bias	Note=Cys-rich
EPHA5	P54756	355	467	369	369	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	355	467	423	423	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	355	467	436	436	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	355	467	461	461	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA5	P54756	597	618	597	619	Alternative sequence	ID=VSP_002999;Note=In isoform 2. SCCECGCGRASSLCAVAHPSLIW->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHA5	P54756	303	355	330	330	Natural variant	ID=VAR_042140;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56205382,PMID:17344846
EPHA5	P54756	355	467	417	417	Natural variant	ID=VAR_042141;Note=In a lung adenocarcinoma sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs199614818,PMID:17344846
EPHA5	P54756	597	618	611	611	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHA5	P54756	597	618	616	616	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPS8L3	Q8TE67	478	521	1	593	Chain	ID=PRO_0000239087;Note=Epidermal growth factor receptor kinase substrate 8-like protein 3
EPS8L3	Q8TE67	85	135	1	593	Chain	ID=PRO_0000239087;Note=Epidermal growth factor receptor kinase substrate 8-like protein 3
EPS8L3	Q8TE67	32	85	1	593	Chain	ID=PRO_0000239087;Note=Epidermal growth factor receptor kinase substrate 8-like protein 3
EPS8L3	Q8TE67	478	521	450	509	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
EPS8L3	Q8TE67	32	85	35	35	Natural variant	ID=VAR_050976;Note=M->I;Dbxref=dbSNP:rs17598321
EPS8L3	Q8TE67	478	521	476	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WXT
EPS8L3	Q8TE67	478	521	483	490	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WXT
EPS8L3	Q8TE67	478	521	496	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WXT
EPS8L3	Q8TE67	478	521	501	503	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WXT
SLC1A6	P48664	455	499	1	564	Chain	ID=PRO_0000202070;Note=Excitatory amino acid transporter 4
SLC1A6	P48664	312	389	1	564	Chain	ID=PRO_0000202070;Note=Excitatory amino acid transporter 4
SLC1A6	P48664	312	389	295	322	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	312	389	344	365	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	312	389	371	401	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	455	499	451	484	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	455	499	498	519	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	312	389	388	390	Region	Note=Aspartate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	455	499	468	472	Region	Note=Aspartate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A6	P48664	455	499	313	564	Alternative sequence	ID=VSP_055130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC1A6	P48664	312	389	313	564	Alternative sequence	ID=VSP_055130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC1A2	P43004	429	473	1	574	Chain	ID=PRO_0000202061;Note=Excitatory amino acid transporter 2
SLC1A2	P43004	286	363	1	574	Chain	ID=PRO_0000202061;Note=Excitatory amino acid transporter 2
SLC1A2	P43004	286	363	269	296	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	286	363	297	317	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A2	P43004	286	363	318	339	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	286	363	340	344	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A2	P43004	286	363	345	375	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	429	473	425	458	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	429	473	459	471	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A2	P43004	429	473	472	493	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	286	363	362	364	Region	Note=Aspartate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	429	473	442	446	Region	Note=Aspartate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A2	P43004	286	363	289	289	Natural variant	ID=VAR_080229;Note=In EIEE41. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28777935;Dbxref=PMID:28777935
SLC1A2	P43004	286	363	263	289	Sequence conflict	Note=AKLMVDFFNILNEIVMKLVIMIMWYSP->GQADGGFLQHFERDCNEVSDHDHVVLS;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A2	P43004	286	363	347	347	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFHC1	Q5JVL4	95	191	1	640	Chain	ID=PRO_0000073877;Note=EF-hand domain-containing protein 1
EFHC1	Q5JVL4	379	426	1	640	Chain	ID=PRO_0000073877;Note=EF-hand domain-containing protein 1
EFHC1	Q5JVL4	95	191	93	198	Domain	Note=DM10 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00665
EFHC1	Q5JVL4	379	426	416	520	Domain	Note=DM10 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00665
EFHC1	Q5JVL4	379	426	279	640	Alternative sequence	ID=VSP_015895;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15258581;Dbxref=PMID:15258581
EFHC1	Q5JVL4	95	191	118	118	Natural variant	ID=VAR_072108;Note=In EJM1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22727576;Dbxref=dbSNP:rs764096785,PMID:22727576
EFHC1	Q5JVL4	95	191	153	153	Natural variant	ID=VAR_072109;Note=In EJM1%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22727576;Dbxref=dbSNP:rs745600475,PMID:22727576
EFHC1	Q5JVL4	95	191	159	159	Natural variant	ID=VAR_023620;Note=Polymorphism%3B no effect on cell death%3B binds to CACNA1E as the wild type protein%3B does not affect subcellular location. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15258581,ECO:0000269|PubMed:17159113,ECO:0000269|PubMed:22926142,ECO:0000269|PubMed:28370826;Dbxref=dbSNP:rs3804506,PMID:15258581,PMID:17159113,PMID:22926142,PMID:28370826
EFHC1	Q5JVL4	95	191	174	174	Natural variant	ID=VAR_043154;Note=Associated with susceptibility to JAE1. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17159113;Dbxref=dbSNP:rs137852779,PMID:17159113
EFHC1	Q5JVL4	95	191	182	182	Natural variant	ID=VAR_072110;Note=In EJM1%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22727576;Dbxref=dbSNP:rs200191497,PMID:22727576
EFHC1	Q5JVL4	95	191	182	182	Natural variant	ID=VAR_023621;Note=Likely benign polymorphism%3B no effect on cell death%3B binds to CACNA1E. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15258581,ECO:0000269|PubMed:17159113,ECO:0000269|PubMed:17634063,ECO:0000269|PubMed:28370826;Dbxref=dbSNP:rs3804505,PMID:15258581,PMID:17159113,PMID:17634063,PMID:28370826
EFHC1	Q5JVL4	379	426	394	394	Natural variant	ID=VAR_043158;Note=In a sporadic case of unclassified epilepsy. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17159113;Dbxref=PMID:17159113
EFHC1	Q5JVL4	95	191	140	140	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFHC1	Q5JVL4	379	426	399	399	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GRK5	P34947	322	352	1	590	Chain	ID=PRO_0000085971;Note=G protein-coupled receptor kinase 5
GRK5	P34947	322	352	186	448	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GRK5	P34947	322	352	325	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TND
GRK5	P34947	322	352	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TND
GRM5	P41594	877	908	21	1212	Chain	ID=PRO_0000012932;Note=Metabotropic glutamate receptor 5
GRM5	P41594	877	908	821	1212	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25042998;Dbxref=PMID:25042998
GRM5	P41594	877	908	877	908	Alternative sequence	ID=VSP_002030;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7908515;Dbxref=PMID:7908515
GRM5	P41594	877	908	896	1165	Alternative sequence	ID=VSP_047710;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
EIF2B1	Q14232	161	183	1	305	Chain	ID=PRO_0000156055;Note=Translation initiation factor eIF-2B subunit alpha
EIF2B1	Q14232	161	183	162	222	Alternative sequence	ID=VSP_055469;Note=In isoform 2. KKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ->QVPFCSVMCPAIILQSKLRITVQQDQNQNVPPACQQSALPFIVPFPAFGRKITEFAAGRSI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EIF2B1	Q14232	161	183	183	183	Natural variant	ID=VAR_068450;Note=In VWM. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776425;Dbxref=dbSNP:rs863225048,PMID:15776425
EIF2B1	Q14232	161	183	160	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	175	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	180	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	183	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B5	Q13144	228	255	2	721	Chain	ID=PRO_0000156073;Note=Translation initiation factor eIF-2B subunit epsilon
EIF2B5	Q13144	255	281	2	721	Chain	ID=PRO_0000156073;Note=Translation initiation factor eIF-2B subunit epsilon
EIF2B5	Q13144	255	281	269	269	Natural variant	ID=VAR_068461;Note=In VWM. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776425;Dbxref=dbSNP:rs113994058,PMID:15776425
EIF2B5	Q13144	255	281	269	269	Natural variant	ID=VAR_068462;Note=In VWM. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19158808;Dbxref=dbSNP:rs113994057,PMID:19158808
EIF2B5	Q13144	255	281	270	270	Natural variant	ID=VAR_068463;Note=In VWM. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21484434;Dbxref=dbSNP:rs397514646,PMID:21484434
EIF2B5	Q13144	228	255	229	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	228	255	238	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	228	255	244	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	228	255	254	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	255	281	254	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	255	281	269	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
ELAVL4	P26378	245	257	1	380	Chain	ID=PRO_0000081583;Note=ELAV-like protein 4
ELF1	P32519	269	418	1	619	Chain	ID=PRO_0000204085;Note=ETS-related transcription factor Elf-1
ELF1	P32519	176	204	1	619	Chain	ID=PRO_0000204085;Note=ETS-related transcription factor Elf-1
ELF1	P32519	269	418	208	290	DNA binding	Note=ETS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00237
ELF1	P32519	176	204	187	187	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ELF1	P32519	176	204	190	190	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ELF1	P32519	269	418	343	343	Natural variant	ID=VAR_048943;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1056820,PMID:14702039
ELF1	P32519	269	418	403	403	Natural variant	ID=VAR_048944;Note=T->I;Dbxref=dbSNP:rs7323148
ELK3	P41970	69	334	1	407	Chain	ID=PRO_0000204097;Note=ETS domain-containing protein Elk-3
ELK3	P41970	334	375	1	407	Chain	ID=PRO_0000204097;Note=ETS domain-containing protein Elk-3
ELK3	P41970	69	334	5	85	DNA binding	Note=ETS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00237
ELK3	P41970	69	334	273	277	Motif	Note=CTBP-binding motif
ELK3	P41970	69	334	207	212	Compositional bias	Note=Poly-Ala
ELK3	P41970	69	334	115	115	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
ELK3	P41970	69	334	92	92	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ELK3	P41970	69	334	165	165	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ELK3	P41970	69	334	169	169	Natural variant	ID=VAR_048946;Note=P->L;Dbxref=dbSNP:rs35332676
ELK3	P41970	69	334	114	114	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK3	P41970	69	334	117	117	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK3	P41970	69	334	128	128	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK3	P41970	69	334	152	152	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK3	P41970	69	334	163	163	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK3	P41970	69	334	249	249	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK4	P28324	360	399	1	431	Chain	ID=PRO_0000204099;Note=ETS domain-containing protein Elk-4
ELK4	P28324	360	399	361	431	Alternative sequence	ID=VSP_001468;Note=In isoform 2. TPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT->VACSLFMVSPLLSFICPFKQIQNLYTQVCFLLLRFVLERLCVTVM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ELL2	O00472	587	602	1	640	Chain	ID=PRO_0000146735;Note=RNA polymerase II elongation factor ELL2
ELL2	O00472	587	602	584	602	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JW9
EML1	O00423	22	83	1	815	Chain	ID=PRO_0000050961;Note=Echinoderm microtubule-associated protein-like 1
EML1	O00423	299	336	1	815	Chain	ID=PRO_0000050961;Note=Echinoderm microtubule-associated protein-like 1
EML1	O00423	336	368	1	815	Chain	ID=PRO_0000050961;Note=Echinoderm microtubule-associated protein-like 1
EML1	O00423	540	584	1	815	Chain	ID=PRO_0000050961;Note=Echinoderm microtubule-associated protein-like 1
EML1	O00423	299	336	261	310	Repeat	Note=WD 1
EML1	O00423	299	336	315	358	Repeat	Note=WD 2
EML1	O00423	336	368	315	358	Repeat	Note=WD 2
EML1	O00423	336	368	363	400	Repeat	Note=WD 3
EML1	O00423	540	584	535	572	Repeat	Note=WD 7
EML1	O00423	540	584	578	613	Repeat	Note=WD 8
EML1	O00423	299	336	176	815	Region	Note=Tandem atypical propeller in EMLs
EML1	O00423	336	368	176	815	Region	Note=Tandem atypical propeller in EMLs
EML1	O00423	540	584	176	815	Region	Note=Tandem atypical propeller in EMLs
EML1	O00423	540	584	552	552	Natural variant	ID=VAR_031721;Note=H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853154,PMID:15489334
EML1	O00423	540	584	556	556	Natural variant	ID=VAR_031722;Note=S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9226380,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2250718,PMID:15489334,PMID:9226380
EML1	O00423	22	83	59	61	Mutagenesis	Note=No effect on tubulin binding. LAD->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24706829;Dbxref=PMID:24706829
EML1	O00423	540	584	547	547	Mutagenesis	Note=Abolishes tubulin binding%3B when associated with S-192%3B S-194%3B T-626%3B S-627%3B A-646 and A-786. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24706829;Dbxref=PMID:24706829
EML1	O00423	299	336	305	309	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	299	336	310	312	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	299	336	315	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	299	336	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	299	336	326	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	299	336	335	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	336	368	335	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	336	368	342	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	336	368	348	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	336	368	352	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	336	368	358	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	336	368	362	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	540	584	546	551	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	540	584	553	562	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	540	584	565	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	540	584	572	575	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML1	O00423	540	584	576	582	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI8
EML2	O95834	374	418	1	649	Chain	ID=PRO_0000050962;Note=Echinoderm microtubule-associated protein-like 2
EML2	O95834	202	247	1	649	Chain	ID=PRO_0000050962;Note=Echinoderm microtubule-associated protein-like 2
EML2	O95834	170	202	1	649	Chain	ID=PRO_0000050962;Note=Echinoderm microtubule-associated protein-like 2
EML2	O95834	170	202	151	192	Repeat	Note=WD 3
EML2	O95834	202	247	195	234	Repeat	Note=WD 4
EML2	O95834	170	202	195	234	Repeat	Note=WD 4
EML2	O95834	202	247	241	280	Repeat	Note=WD 5
EML2	O95834	374	418	369	406	Repeat	Note=WD 7
EML2	O95834	374	418	410	447	Repeat	Note=WD 8
EML2	O95834	374	418	10	649	Region	Note=Tandem atypical propeller in EMLs;Ontology_term=ECO:0000250;evidence=ECO:0000250
EML2	O95834	202	247	10	649	Region	Note=Tandem atypical propeller in EMLs;Ontology_term=ECO:0000250;evidence=ECO:0000250
EML2	O95834	170	202	10	649	Region	Note=Tandem atypical propeller in EMLs;Ontology_term=ECO:0000250;evidence=ECO:0000250
EML2	O95834	170	202	187	187	Natural variant	ID=VAR_031724;Note=L->F;Dbxref=dbSNP:rs7252175
EML2	O95834	202	247	235	235	Natural variant	ID=VAR_024697;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs1545040
EML6	Q6ZMW3	350	395	1	1958	Chain	ID=PRO_0000325976;Note=Echinoderm microtubule-associated protein-like 6
EML6	Q6ZMW3	1404	1437	1	1958	Chain	ID=PRO_0000325976;Note=Echinoderm microtubule-associated protein-like 6
EML6	Q6ZMW3	350	395	323	362	Repeat	Note=WD 7
EML6	Q6ZMW3	350	395	364	403	Repeat	Note=WD 8
EML6	Q6ZMW3	1404	1437	1412	1456	Repeat	Note=WD 21
ERMARD	Q5T6L9	105	139	1	678	Chain	ID=PRO_0000295626;Note=Endoplasmic reticulum membrane-associated RNA degradation protein
ERMARD	Q5T6L9	320	330	1	678	Chain	ID=PRO_0000295626;Note=Endoplasmic reticulum membrane-associated RNA degradation protein
ERMARD	Q5T6L9	411	439	1	678	Chain	ID=PRO_0000295626;Note=Endoplasmic reticulum membrane-associated RNA degradation protein
ERMARD	Q5T6L9	507	579	1	678	Chain	ID=PRO_0000295626;Note=Endoplasmic reticulum membrane-associated RNA degradation protein
ERMARD	Q5T6L9	580	617	1	678	Chain	ID=PRO_0000295626;Note=Endoplasmic reticulum membrane-associated RNA degradation protein
ERMARD	Q5T6L9	580	617	587	607	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERMARD	Q5T6L9	105	139	1	126	Alternative sequence	ID=VSP_053708;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERMARD	Q5T6L9	507	579	508	580	Alternative sequence	ID=VSP_026951;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERMARD	Q5T6L9	580	617	508	580	Alternative sequence	ID=VSP_026951;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERMARD	Q5T6L9	507	579	508	579	Alternative sequence	ID=VSP_026952;Note=In isoform 3. WPQLLRELCSTPVPTLFCPRIVLEVLVVLRSISEQCRRVSSQVTVASELRHRQWVERTLRSRQRQNYLRMWS->PTSDTPLALAPRKPQPCRCRRRVRP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERMARD	Q5T6L9	507	579	540	540	Natural variant	ID=VAR_033300;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs4716346,PMID:14702039
EMC3	Q9P0I2	102	137	2	261	Chain	ID=PRO_0000211406;Note=ER membrane protein complex subunit 3
EMC3	Q9P0I2	102	137	118	138	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMD	P50402	62	88	1	254	Chain	ID=PRO_0000206140;Note=Emerin
EMD	P50402	62	88	46	222	Region	Note=Interaction with F-actin;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMD	P50402	62	88	87	87	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
EMP2	P54851	56	105	1	167	Chain	ID=PRO_0000164658;Note=Epithelial membrane protein 2
EMP2	P54851	56	105	1	167	Chain	ID=PRO_0000164658;Note=Epithelial membrane protein 2
EMP2	P54851	56	105	67	87	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP2	P54851	56	105	67	87	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP2	P54851	56	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP2	P54851	56	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP2	P54851	56	105	64	64	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMP2	P54851	56	105	64	64	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
GCSAML	Q5JQS6	10	29	1	135	Chain	ID=PRO_0000294242;Note=Germinal center-associated signaling and motility-like protein
GCSAML	Q5JQS6	10	29	26	50	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GCSAML	Q5JQS6	10	29	10	29	Alternative sequence	ID=VSP_026612;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GSAP	A4D1B5	757	791	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	609	641	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	515	558	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	497	515	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	342	373	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	290	316	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	192	227	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	62	81	1	854	Chain	ID=PRO_0000335809;Note=Gamma-secretase-activating protein
GSAP	A4D1B5	757	791	734	854	Chain	ID=PRO_0000403728;Note=Gamma-secretase-activating protein 16 kDa C-terminal form;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSAP	A4D1B5	515	558	1	606	Alternative sequence	ID=VSP_033771;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSAP	A4D1B5	497	515	1	606	Alternative sequence	ID=VSP_033771;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSAP	A4D1B5	342	373	1	606	Alternative sequence	ID=VSP_033771;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSAP	A4D1B5	290	316	1	606	Alternative sequence	ID=VSP_033771;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSAP	A4D1B5	192	227	1	606	Alternative sequence	ID=VSP_033771;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSAP	A4D1B5	62	81	1	606	Alternative sequence	ID=VSP_033771;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSAP	A4D1B5	757	791	560	854	Alternative sequence	ID=VSP_033774;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GSAP	A4D1B5	609	641	560	854	Alternative sequence	ID=VSP_033774;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GSAP	A4D1B5	290	316	305	305	Natural variant	ID=VAR_043468;Note=G->E;Dbxref=dbSNP:rs1527263
ENAH	Q8N8S7	513	533	1	591	Chain	ID=PRO_0000086971;Note=Protein enabled homolog
ENAH	Q8N8S7	267	304	1	591	Chain	ID=PRO_0000086971;Note=Protein enabled homolog
ENAH	Q8N8S7	513	533	391	588	Region	Note=EVH2
ENAH	Q8N8S7	267	304	268	304	Alternative sequence	ID=VSP_053772;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:23129656;Dbxref=PMID:23129656
ENAH	Q8N8S7	513	533	513	533	Alternative sequence	ID=VSP_053773;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:23129656;Dbxref=PMID:23129656
ENAH	Q8N8S7	513	533	514	534	Alternative sequence	ID=VSP_010564;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
DPCD	Q9BVM2	21	48	1	203	Chain	ID=PRO_0000323723;Note=Protein DPCD
POLA2	Q14181	248	300	1	598	Chain	ID=PRO_0000194035;Note=DNA polymerase alpha subunit B
POLA2	Q14181	248	300	251	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA2	Q14181	248	300	267	269	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA2	Q14181	248	300	270	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA2	Q14181	248	300	276	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA2	Q14181	248	300	283	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA2	Q14181	248	300	292	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLD1	P28340	154	196	1	1107	Chain	ID=PRO_0000046442;Note=DNA polymerase delta catalytic subunit
POLD1	P28340	750	796	1	1107	Chain	ID=PRO_0000046442;Note=DNA polymerase delta catalytic subunit
POLD1	P28340	154	196	1	1107	Chain	ID=PRO_0000046442;Note=DNA polymerase delta catalytic subunit
POLD1	P28340	750	796	1	1107	Chain	ID=PRO_0000046442;Note=DNA polymerase delta catalytic subunit
POLD1	P28340	154	196	173	173	Natural variant	ID=VAR_019342;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1542570,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1726803,PMID:1542570
POLD1	P28340	154	196	173	173	Natural variant	ID=VAR_019342;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1542570,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1726803,PMID:1542570
POLD1	P28340	154	196	177	177	Natural variant	ID=VAR_019343;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs3218750
POLD1	P28340	154	196	177	177	Natural variant	ID=VAR_019343;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs3218750
POLD1	P28340	750	796	787	787	Natural variant	ID=VAR_069336;Note=Found in a colorectal sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs199783227,PMID:23263490
POLD1	P28340	750	796	787	787	Natural variant	ID=VAR_069336;Note=Found in a colorectal sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs199783227,PMID:23263490
POLD1	P28340	750	796	776	776	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLD1	P28340	750	796	776	776	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLD2	P49005	382	416	1	469	Chain	ID=PRO_0000096166;Note=DNA polymerase delta subunit 2
POLD2	P49005	382	416	1	469	Chain	ID=PRO_0000096166;Note=DNA polymerase delta subunit 2
POLD2	P49005	382	416	400	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E0J
POLD2	P49005	382	416	400	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E0J
POLD2	P49005	382	416	411	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E0J
POLD2	P49005	382	416	411	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E0J
POLN	Q7Z5Q5	688	732	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	596	622	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	555	577	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	537	555	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	518	537	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	393	416	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	688	732	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	596	622	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	555	577	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	537	555	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	518	537	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	393	416	1	900	Chain	ID=PRO_0000227938;Note=DNA polymerase nu
POLN	Q7Z5Q5	596	622	578	610	Alternative sequence	ID=VSP_054402;Note=In isoform 2. NIQGISKHPIQITTPKNFKGKEDKILTISPRAM->ICARQVASDFQKCVEVSDAMMNSSIFWWLLKLY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLN	Q7Z5Q5	596	622	578	610	Alternative sequence	ID=VSP_054402;Note=In isoform 2. NIQGISKHPIQITTPKNFKGKEDKILTISPRAM->ICARQVASDFQKCVEVSDAMMNSSIFWWLLKLY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLN	Q7Z5Q5	688	732	611	899	Alternative sequence	ID=VSP_054403;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLN	Q7Z5Q5	596	622	611	899	Alternative sequence	ID=VSP_054403;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLN	Q7Z5Q5	688	732	611	899	Alternative sequence	ID=VSP_054403;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLN	Q7Z5Q5	596	622	611	899	Alternative sequence	ID=VSP_054403;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLN	Q7Z5Q5	688	732	711	711	Natural variant	ID=VAR_025654;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs34554757
POLN	Q7Z5Q5	688	732	711	711	Natural variant	ID=VAR_025654;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs34554757
POLN	Q7Z5Q5	393	416	390	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	393	416	390	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	518	537	516	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	518	537	516	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	518	537	522	525	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	518	537	522	525	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	537	555	528	545	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	518	537	528	545	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	537	555	528	545	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	518	537	528	545	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	537	555	547	550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	537	555	547	550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	555	577	561	566	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	555	577	561	566	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	555	577	568	570	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	555	577	568	570	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	555	577	573	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	555	577	573	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	596	622	602	605	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	596	622	602	605	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	596	622	607	610	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	596	622	607	610	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	596	622	618	624	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	596	622	618	624	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	688	732	690	696	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	688	732	690	696	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	688	732	701	714	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	688	732	701	714	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	688	732	717	732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLN	Q7Z5Q5	688	732	717	732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XVK
POLQ	O75417	2135	2181	1	2590	Chain	ID=PRO_0000101279;Note=DNA polymerase theta
POLQ	O75417	2135	2181	2142	2177	Region	Note=Loop 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21050863;Dbxref=PMID:21050863
DSE	Q9UL01	223	303	23	958	Chain	ID=PRO_0000223311;Note=Dermatan-sulfate epimerase
DSE	Q9UL01	223	303	23	958	Chain	ID=PRO_0000223311;Note=Dermatan-sulfate epimerase
DSE	Q9UL01	223	303	268	268	Natural variant	ID=VAR_070911;Note=In EDSMC2%3B shows a loss of epimerase activity towards partially desulfated dermatan sulfate%3B patient-derived fibroblasts show also a significant reduction in activity. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23704329;Dbxref=dbSNP:rs398122361,PMID:23704329
DSE	Q9UL01	223	303	268	268	Natural variant	ID=VAR_070911;Note=In EDSMC2%3B shows a loss of epimerase activity towards partially desulfated dermatan sulfate%3B patient-derived fibroblasts show also a significant reduction in activity. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23704329;Dbxref=dbSNP:rs398122361,PMID:23704329
DSE	Q9UL01	223	303	282	282	Natural variant	ID=VAR_053834;Note=I->V;Dbxref=dbSNP:rs34994230
DSE	Q9UL01	223	303	282	282	Natural variant	ID=VAR_053834;Note=I->V;Dbxref=dbSNP:rs34994230
DTHD1	Q6ZMT9	423	476	1	781	Chain	ID=PRO_0000349274;Note=Death domain-containing protein 1
DTHD1	Q6ZMT9	423	476	302	483	Domain	Note=ZU5 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00485
DTX4	Q9Y2E6	512	542	1	619	Chain	ID=PRO_0000280555;Note=E3 ubiquitin-protein ligase DTX4
DYNLT1	P63172	9	23	1	113	Chain	ID=PRO_0000195152;Note=Dynein light chain Tctex-type 1
DYNLT1	P63172	9	23	8	10	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JPW
DYNLT1	P63172	9	23	14	29	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JPW
DZIP1	Q86YF9	492	512	1	867	Chain	ID=PRO_0000047106;Note=Zinc finger protein DZIP1
DZIP1	Q86YF9	454	473	1	867	Chain	ID=PRO_0000047106;Note=Zinc finger protein DZIP1
DZIP1	Q86YF9	324	370	1	867	Chain	ID=PRO_0000047106;Note=Zinc finger protein DZIP1
DZIP1	Q86YF9	492	512	1	867	Chain	ID=PRO_0000047106;Note=Zinc finger protein DZIP1
DZIP1	Q86YF9	454	473	1	867	Chain	ID=PRO_0000047106;Note=Zinc finger protein DZIP1
DZIP1	Q86YF9	324	370	1	867	Chain	ID=PRO_0000047106;Note=Zinc finger protein DZIP1
DZIP1	Q86YF9	324	370	230	340	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DZIP1	Q86YF9	324	370	230	340	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DZIP1	Q86YF9	492	512	232	867	Alternative sequence	ID=VSP_010964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12511597;Dbxref=PMID:12511597
DZIP1	Q86YF9	454	473	232	867	Alternative sequence	ID=VSP_010964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12511597;Dbxref=PMID:12511597
DZIP1	Q86YF9	324	370	232	867	Alternative sequence	ID=VSP_010964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12511597;Dbxref=PMID:12511597
DZIP1	Q86YF9	492	512	232	867	Alternative sequence	ID=VSP_010964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12511597;Dbxref=PMID:12511597
DZIP1	Q86YF9	454	473	232	867	Alternative sequence	ID=VSP_010964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12511597;Dbxref=PMID:12511597
DZIP1	Q86YF9	324	370	232	867	Alternative sequence	ID=VSP_010964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12511597;Dbxref=PMID:12511597
DZIP1	Q86YF9	454	473	455	474	Alternative sequence	ID=VSP_010965;Note=In isoform 2. GNPLAWQAFESQPAAPAVPM->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
DZIP1	Q86YF9	454	473	455	474	Alternative sequence	ID=VSP_010965;Note=In isoform 2. GNPLAWQAFESQPAAPAVPM->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
DNM1	Q05193	196	229	1	864	Chain	ID=PRO_0000206563;Note=Dynamin-1
DNM1	Q05193	196	229	28	294	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
DNM1	Q05193	196	229	205	208	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNM1	Q05193	196	229	205	208	Region	Note=G4 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
DNM1	Q05193	196	229	206	206	Natural variant	ID=VAR_073711;Note=In EIEE31. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25262651;Dbxref=dbSNP:rs587777861,PMID:25262651
DNM1	Q05193	196	229	198	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D3Q
DNM1	Q05193	196	229	207	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D3Q
DNM1	Q05193	196	229	217	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D3Q
GRAMD1C	Q8IYS0	9	58	1	662	Chain	ID=PRO_0000287451;Note=GRAM domain-containing protein 1C
GRAMD1C	Q8IYS0	121	153	1	662	Chain	ID=PRO_0000287451;Note=GRAM domain-containing protein 1C
GRAMD1C	Q8IYS0	317	363	1	662	Chain	ID=PRO_0000287451;Note=GRAM domain-containing protein 1C
GRAMD1C	Q8IYS0	485	544	1	662	Chain	ID=PRO_0000287451;Note=GRAM domain-containing protein 1C
GRAMD1C	Q8IYS0	564	600	1	662	Chain	ID=PRO_0000287451;Note=GRAM domain-containing protein 1C
GRAMD1C	Q8IYS0	564	600	557	577	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRAMD1C	Q8IYS0	121	153	69	136	Domain	Note=GRAM
GRAMD1C	Q8IYS0	317	363	326	497	Domain	Note=VASt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01114
GRAMD1C	Q8IYS0	485	544	326	497	Domain	Note=VASt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01114
GRAMD1C	Q8IYS0	9	58	1	205	Alternative sequence	ID=VSP_025477;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:12975309,PMID:14702039
GRAMD1C	Q8IYS0	121	153	1	205	Alternative sequence	ID=VSP_025477;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:12975309,PMID:14702039
GRAMD1C	Q8IYS0	485	544	503	506	Sequence conflict	Note=PGKL->AVHH;Ontology_term=ECO:0000305;evidence=ECO:0000305
TUFM	P49411	272	307	44	452	Chain	ID=PRO_0000007462;Note=Elongation factor Tu%2C mitochondrial
TUFM	P49411	272	307	278	278	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TUFM	P49411	272	307	286	286	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BFR5
ENG	P17813	580	617	26	658	Chain	ID=PRO_0000021156;Note=Endoglin
ENG	P17813	476	562	26	658	Chain	ID=PRO_0000021156;Note=Endoglin
ENG	P17813	437	476	26	658	Chain	ID=PRO_0000021156;Note=Endoglin
ENG	P17813	424	437	26	658	Chain	ID=PRO_0000021156;Note=Endoglin
ENG	P17813	73	120	26	658	Chain	ID=PRO_0000021156;Note=Endoglin
ENG	P17813	580	617	26	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	476	562	26	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	437	476	26	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	424	437	26	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	73	120	26	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	580	617	587	611	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	580	617	612	658	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	476	562	363	533	Domain	Note=ZP;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00375,ECO:0000305|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	437	476	363	533	Domain	Note=ZP;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00375,ECO:0000305|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	424	437	363	533	Domain	Note=ZP;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00375,ECO:0000305|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	73	120	26	337	Region	Note=Required for interaction with GDF2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21737454,ECO:0000269|PubMed:22347366,ECO:0000269|PubMed:28564608;Dbxref=PMID:21737454,PMID:22347366,PMID:28564608
ENG	P17813	73	120	47	199	Region	Note=OR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	476	562	336	576	Compositional bias	Note=Ser/Thr-rich
ENG	P17813	437	476	336	576	Compositional bias	Note=Ser/Thr-rich
ENG	P17813	424	437	336	576	Compositional bias	Note=Ser/Thr-rich
ENG	P17813	73	120	88	88	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	73	120	102	102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENG	P17813	73	120	30	207	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5HZW,ECO:0000244|PDB:5I04,ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	73	120	53	182	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5HZW,ECO:0000244|PDB:5I04,ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	437	476	363	442	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5HZV,ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	424	437	363	442	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5HZV,ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	476	562	493	549	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5HZV,ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	476	562	516	516	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	73	120	105	105	Natural variant	ID=VAR_070280;Note=In HHT1. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=PMID:16752392
ENG	P17813	73	120	107	107	Natural variant	ID=VAR_026776;Note=In HHT1. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15024723;Dbxref=PMID:15024723
ENG	P17813	437	476	437	437	Natural variant	ID=VAR_070297;Note=In HHT1. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=PMID:16752392
ENG	P17813	424	437	437	437	Natural variant	ID=VAR_070297;Note=In HHT1. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=PMID:16752392
ENG	P17813	476	562	490	490	Natural variant	ID=VAR_070298;Note=In HHT1. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=dbSNP:rs763475207,PMID:16752392
ENG	P17813	476	562	504	504	Natural variant	ID=VAR_026782;Note=In HHT1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15024723;Dbxref=dbSNP:rs116330805,PMID:15024723
ENG	P17813	476	562	529	529	Natural variant	ID=VAR_070299;Note=In HHT1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=dbSNP:rs863223538,PMID:16752392
ENG	P17813	476	562	529	529	Natural variant	ID=VAR_070300;Note=In HHT1. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20414677;Dbxref=PMID:20414677
ENG	P17813	476	562	545	545	Natural variant	ID=VAR_070301;Note=In HHT1. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16525724;Dbxref=PMID:16525724
ENG	P17813	476	562	545	545	Natural variant	ID=VAR_070302;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20414677;Dbxref=dbSNP:rs142896669,PMID:20414677
ENG	P17813	476	562	547	547	Natural variant	ID=VAR_070303;Note=In HHT1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=PMID:16752392
ENG	P17813	476	562	549	549	Natural variant	ID=VAR_070304;Note=Found in a patient with hereditary hemorrhagic talagiectasia%3B unknown pathological significance. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20414677;Dbxref=dbSNP:rs1060501421,PMID:20414677
ENG	P17813	476	562	561	561	Natural variant	ID=VAR_070305;Note=D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20414677;Dbxref=dbSNP:rs375965489,PMID:20414677
ENG	P17813	580	617	603	603	Natural variant	ID=VAR_070306;Note=In HHT1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20414677;Dbxref=PMID:20414677
ENG	P17813	580	617	604	604	Natural variant	ID=VAR_070307;Note=In HHT1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16752392;Dbxref=PMID:16752392
ENG	P17813	580	617	615	615	Natural variant	ID=VAR_026783;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712270;Dbxref=dbSNP:rs148002300,PMID:15712270
ENG	P17813	476	562	516	516	Mutagenesis	Note=Loss of dimerization via ZP domain. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28564608;Dbxref=PMID:28564608
ENG	P17813	73	120	76	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I04
ENG	P17813	73	120	94	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I04
ENG	P17813	73	120	105	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I04
ENG	P17813	73	120	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I04
ENG	P17813	424	437	420	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	437	476	436	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	424	437	436	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	437	476	445	447	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	437	476	448	459	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	437	476	465	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	473	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	437	476	473	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	484	496	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	499	501	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	503	508	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	517	519	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	524	526	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	529	532	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	538	540	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	543	555	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
ENG	P17813	476	562	560	562	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZV
GSTA3	Q16772	138	182	2	222	Chain	ID=PRO_0000185785;Note=Glutathione S-transferase A3
GSTA3	Q16772	138	182	85	207	Domain	Note=GST C-terminal
GSTA3	Q16772	138	182	132	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VCV
GSTA3	Q16772	138	182	146	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VCV
GSTA3	Q16772	138	182	155	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VCV
GSTA3	Q16772	138	182	172	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VCV
GSTA3	Q16772	138	182	179	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VCV
ENTPD3	O75355	405	451	1	529	Chain	ID=PRO_0000209910;Note=Ectonucleoside triphosphate diphosphohydrolase 3
ENTPD3	O75355	405	451	1	529	Chain	ID=PRO_0000209910;Note=Ectonucleoside triphosphate diphosphohydrolase 3
ENTPD3	O75355	405	451	44	485	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD3	O75355	405	451	44	485	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD3	O75355	405	451	399	422	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724
ENTPD3	O75355	405	451	399	422	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724
ENTPD3	O75355	405	451	440	440	Natural variant	ID=VAR_027541;Note=E->D;Dbxref=dbSNP:rs4470483
ENTPD3	O75355	405	451	440	440	Natural variant	ID=VAR_027541;Note=E->D;Dbxref=dbSNP:rs4470483
EOGT	Q5NDL2	308	332	18	527	Chain	ID=PRO_0000301970;Note=EGF domain-specific O-linked N-acetylglucosamine transferase
EOGT	Q5NDL2	207	231	18	527	Chain	ID=PRO_0000301970;Note=EGF domain-specific O-linked N-acetylglucosamine transferase
EOGT	Q5NDL2	207	231	208	208	Alternative sequence	ID=VSP_027897;Note=In isoform 2. F->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EOGT	Q5NDL2	308	332	209	527	Alternative sequence	ID=VSP_027898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EOGT	Q5NDL2	207	231	209	527	Alternative sequence	ID=VSP_027898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EOGT	Q5NDL2	308	332	278	361	Alternative sequence	ID=VSP_027899;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EOGT	Q5NDL2	207	231	207	207	Natural variant	ID=VAR_070090;Note=In AOS4. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23522784;Dbxref=dbSNP:rs587776993,PMID:23522784
EPB42	P16452	183	218	2	691	Chain	ID=PRO_0000213720;Note=Erythrocyte membrane protein band 4.2
EPB42	P16452	65	143	2	691	Chain	ID=PRO_0000213720;Note=Erythrocyte membrane protein band 4.2
EPB42	P16452	65	143	112	112	Natural variant	ID=VAR_007482;Note=In SPH5%3B Nippon/Fukuoka. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10406914,ECO:0000269|PubMed:1558976,ECO:0000269|PubMed:7819064,ECO:0000269|PubMed:8547071;Dbxref=dbSNP:rs104894487,PMID:10406914,PMID:1558976,PMID:7819064,PMID:8547071
GTPBP1	O00178	406	467	1	669	Chain	ID=PRO_0000122469;Note=GTP-binding protein 1
EPHA8	P29322	274	326	28	1005	Chain	ID=PRO_0000016822;Note=Ephrin type-A receptor 8
EPHA8	P29322	726	796	28	1005	Chain	ID=PRO_0000016822;Note=Ephrin type-A receptor 8
EPHA8	P29322	274	326	28	542	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA8	P29322	726	796	564	1005	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA8	P29322	726	796	635	896	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA8	P29322	274	326	191	325	Compositional bias	Note=Cys-rich
EPHA8	P29322	726	796	760	760	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
EPHA8	P29322	726	796	496	1005	Alternative sequence	ID=VSP_041947;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EPHA8	P29322	274	326	321	321	Natural variant	ID=VAR_061292;Note=P->L;Dbxref=dbSNP:rs56656925
EPHA8	P29322	726	796	721	726	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KUL
EPHA8	P29322	726	796	727	730	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KUL
EPHA8	P29322	726	796	734	753	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KUL
EPHA8	P29322	726	796	763	765	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KUL
EPHA8	P29322	726	796	766	768	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KUL
EPHA8	P29322	726	796	774	776	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KUL
EPHB2	P29323	270	322	19	1055	Chain	ID=PRO_0000016827;Note=Ephrin type-B receptor 2
EPHB2	P29323	588	629	19	1055	Chain	ID=PRO_0000016827;Note=Ephrin type-B receptor 2
EPHB2	P29323	270	322	19	543	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB2	P29323	588	629	565	1055	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB2	P29323	588	629	621	884	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB2	P29323	588	629	627	635	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB2	P29323	270	322	184	324	Compositional bias	Note=Cys-rich
EPHB2	P29323	270	322	279	279	Natural variant	ID=VAR_032854;Note=In prostate cancer. A->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15300251,ECO:0000269|PubMed:16155194,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35882952,PMID:15300251,PMID:16155194,PMID:17344846
EPHB2	P29323	270	322	289	289	Natural variant	ID=VAR_042172;Note=C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EPHB2	P29323	588	629	589	589	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB2	P29323	588	629	618	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZFM
EPHB2	P29323	588	629	621	626	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZFM
EPHB4	P54760	893	944	16	987	Chain	ID=PRO_0000016834;Note=Ephrin type-B receptor 4
EPHB4	P54760	706	778	16	987	Chain	ID=PRO_0000016834;Note=Ephrin type-B receptor 4
EPHB4	P54760	321	432	16	987	Chain	ID=PRO_0000016834;Note=Ephrin type-B receptor 4
EPHB4	P54760	321	432	16	539	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB4	P54760	893	944	561	987	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB4	P54760	706	778	561	987	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB4	P54760	321	432	323	432	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
EPHB4	P54760	893	944	615	899	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB4	P54760	706	778	615	899	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB4	P54760	893	944	907	971	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
EPHB4	P54760	706	778	740	740	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
EPHB4	P54760	706	778	769	769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPHB4	P54760	706	778	770	770	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPHB4	P54760	893	944	911	911	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
EPHB4	P54760	893	944	943	943	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
EPHB4	P54760	321	432	335	335	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB4	P54760	321	432	426	426	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB4	P54760	893	944	307	987	Alternative sequence	ID=VSP_056021;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	706	778	307	987	Alternative sequence	ID=VSP_056021;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	321	432	307	987	Alternative sequence	ID=VSP_056021;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	321	432	406	414	Alternative sequence	ID=VSP_056022;Note=In isoform 4. VTALNGVSS->YLLQCLTSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	893	944	415	987	Alternative sequence	ID=VSP_056023;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	706	778	415	987	Alternative sequence	ID=VSP_056023;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	321	432	415	987	Alternative sequence	ID=VSP_056023;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	893	944	517	987	Alternative sequence	ID=VSP_056025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	706	778	517	987	Alternative sequence	ID=VSP_056025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB4	P54760	321	432	346	346	Natural variant	ID=VAR_042183;Note=In a metastatic melanoma sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs267601191,PMID:17344846
EPHB4	P54760	321	432	371	371	Natural variant	ID=VAR_042184;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55720981,PMID:17344846
EPHB4	P54760	706	778	739	739	Natural variant	ID=VAR_078063;Note=In HFASD%3B loss of kinase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27400125;Dbxref=dbSNP:rs1057519263,PMID:27400125
EPHB4	P54760	893	944	926	927	Sequence conflict	Note=ES->AR;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB4	P54760	706	778	701	707	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	706	778	708	710	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	706	778	714	733	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	706	778	743	745	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	706	778	746	748	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	706	778	754	756	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	706	778	765	767	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWX
EPHB4	P54760	893	944	912	918	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKQ
EPHB4	P54760	893	944	922	924	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKQ
EPHB4	P54760	893	944	925	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKQ
EPHB4	P54760	893	944	936	939	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKQ
EPHB4	P54760	893	944	944	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKQ
DNAH8	Q96JB1	1217	1238	1	4490	Chain	ID=PRO_0000274044;Note=Dynein heavy chain 8%2C axonemal
DNAH8	Q96JB1	1978	2014	1	4490	Chain	ID=PRO_0000274044;Note=Dynein heavy chain 8%2C axonemal
DNAH8	Q96JB1	3104	3163	1	4490	Chain	ID=PRO_0000274044;Note=Dynein heavy chain 8%2C axonemal
DNAH8	Q96JB1	4009	4061	1	4490	Chain	ID=PRO_0000274044;Note=Dynein heavy chain 8%2C axonemal
DNAH8	Q96JB1	4240	4291	1	4490	Chain	ID=PRO_0000274044;Note=Dynein heavy chain 8%2C axonemal
DNAH8	Q96JB1	1978	2014	1808	2030	Region	Note=AAA 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH8	Q96JB1	3104	3163	3049	3346	Region	Note=Stalk;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH8	Q96JB1	4009	4061	3877	4091	Region	Note=AAA 6;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH8	Q96JB1	3104	3163	3072	3164	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAH8	Q96JB1	1978	2014	1978	2013	Alternative sequence	ID=VSP_022614;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNAH8	Q96JB1	4240	4291	4271	4271	Natural variant	ID=VAR_030179;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12297094;Dbxref=dbSNP:rs10484847,PMID:12297094
EEA1	Q15075	1338	1371	1	1411	Chain	ID=PRO_0000098706;Note=Early endosome antigen 1
EEA1	Q15075	989	1050	1	1411	Chain	ID=PRO_0000098706;Note=Early endosome antigen 1
EEA1	Q15075	681	733	1	1411	Chain	ID=PRO_0000098706;Note=Early endosome antigen 1
EEA1	Q15075	643	681	1	1411	Chain	ID=PRO_0000098706;Note=Early endosome antigen 1
EEA1	Q15075	305	418	1	1411	Chain	ID=PRO_0000098706;Note=Early endosome antigen 1
EEA1	Q15075	1338	1371	1352	1410	Zinc finger	Note=FYVE-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091
EEA1	Q15075	1338	1371	74	1348	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EEA1	Q15075	989	1050	74	1348	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EEA1	Q15075	681	733	74	1348	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EEA1	Q15075	643	681	74	1348	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EEA1	Q15075	305	418	74	1348	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EEA1	Q15075	681	733	397	758	Compositional bias	Note=Gln/Glu/Lys-rich
EEA1	Q15075	643	681	397	758	Compositional bias	Note=Gln/Glu/Lys-rich
EEA1	Q15075	305	418	397	758	Compositional bias	Note=Gln/Glu/Lys-rich
EEA1	Q15075	989	1050	937	1032	Compositional bias	Note=Gln/Glu/Lys-rich
EEA1	Q15075	1338	1371	1349	1349	Mutagenesis	Note=Reduces phosphatidylinositol 3-phosphate binding and endosomal location. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10807926;Dbxref=PMID:10807926
EEA1	Q15075	1338	1371	1352	1352	Mutagenesis	Note=Reduces phosphatidylinositol 3-phosphate binding and endosomal location. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10394369;Dbxref=PMID:10394369
EEA1	Q15075	1338	1371	1357	1357	Mutagenesis	Note=Reduces phosphatidylinositol 3-phosphate binding and endosomal location. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10394369;Dbxref=PMID:10394369
EEA1	Q15075	1338	1371	1358	1358	Mutagenesis	Note=Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10807926;Dbxref=PMID:10807926
EEA1	Q15075	1338	1371	1365	1365	Mutagenesis	Note=Strongly reduces phosphatidylinositol 3-phosphate binding and endosomal location. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10807926;Dbxref=PMID:10807926
EEA1	Q15075	1338	1371	1367	1368	Mutagenesis	Note=Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. VT->EE%2CGG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10394369;Dbxref=PMID:10394369
EEA1	Q15075	1338	1371	1370	1370	Mutagenesis	Note=Abolishes endosomal location. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10807926;Dbxref=PMID:10807926
EEA1	Q15075	1338	1371	1371	1371	Mutagenesis	Note=Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10807926;Dbxref=PMID:10807926
EEA1	Q15075	643	681	680	680	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEA1	Q15075	1338	1371	1326	1346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JOC
EEA1	Q15075	1338	1371	1352	1354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JOC
EEA1	Q15075	1338	1371	1359	1361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JOC
EEA1	Q15075	1338	1371	1367	1369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JOC
EEA1	Q15075	1338	1371	1371	1373	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HYI
GRTP1	Q5TC63	245	307	1	336	Chain	ID=PRO_0000288708;Note=Growth hormone-regulated TBC protein 1
GRTP1	Q5TC63	60	113	1	336	Chain	ID=PRO_0000288708;Note=Growth hormone-regulated TBC protein 1
GRTP1	Q5TC63	245	307	68	258	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
GRTP1	Q5TC63	60	113	68	258	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
GRTP1	Q5TC63	60	113	1	78	Alternative sequence	ID=VSP_025754;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
GRTP1	Q5TC63	245	307	282	282	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELP3	Q9H9T3	131	154	1	547	Chain	ID=PRO_0000283986;Note=Elongator complex protein 3
ELP3	Q9H9T3	419	495	1	547	Chain	ID=PRO_0000283986;Note=Elongator complex protein 3
ELP3	Q9H9T3	419	495	396	547	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
ELP3	Q9H9T3	131	154	13	131	Alternative sequence	ID=VSP_055286;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELP6	Q0PNE2	175	224	1	266	Chain	ID=PRO_0000274360;Note=Elongator complex protein 6
GSE1	Q14687	2	75	1	1217	Chain	ID=PRO_0000050730;Note=Genetic suppressor element 1
GSE1	Q14687	881	919	1	1217	Chain	ID=PRO_0000050730;Note=Genetic suppressor element 1
GSE1	Q14687	2	75	10	10	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GSE1	Q14687	881	919	907	907	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
GSE1	Q14687	881	919	909	909	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
GSE1	Q14687	2	75	1	104	Alternative sequence	ID=VSP_021820;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSE1	Q14687	2	75	3	75	Alternative sequence	ID=VSP_021821;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8724849;Dbxref=PMID:8724849
GSG1L	Q6UXU4	221	276	1	331	Chain	ID=PRO_0000329464;Note=Germ cell-specific gene 1-like protein
GSG1L	Q6UXU4	132	183	1	331	Chain	ID=PRO_0000329464;Note=Germ cell-specific gene 1-like protein
GSG1L	Q6UXU4	132	183	30	132	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSG1L	Q6UXU4	132	183	133	153	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSG1L	Q6UXU4	132	183	154	173	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSG1L	Q6UXU4	132	183	174	194	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSG1L	Q6UXU4	221	276	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSG1L	Q6UXU4	221	276	239	331	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GSG1L	Q6UXU4	132	183	1	155	Alternative sequence	ID=VSP_033516;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
GSG1L	Q6UXU4	132	183	133	183	Alternative sequence	ID=VSP_033004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ENKD1	Q9H0I2	151	193	1	346	Chain	ID=PRO_0000265931;Note=Enkurin domain-containing protein 1
MLLT1	Q03111	182	370	1	559	Chain	ID=PRO_0000215938;Note=Protein ENL
MLLT1	Q03111	140	182	1	559	Chain	ID=PRO_0000215938;Note=Protein ENL
MLLT1	Q03111	92	140	1	559	Chain	ID=PRO_0000215938;Note=Protein ENL
MLLT1	Q03111	92	140	8	112	Domain	Note=YEATS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00376
MLLT1	Q03111	182	370	272	280	Compositional bias	Note=Poly-Pro
MLLT1	Q03111	182	370	319	325	Compositional bias	Note=Poly-Ser
MLLT1	Q03111	140	182	155	155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MLLT1	Q03111	182	370	292	292	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231;Dbxref=PMID:18691976,PMID:19369195,PMID:20068231
MLLT1	Q03111	182	370	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231;Dbxref=PMID:18691976,PMID:20068231
MLLT1	Q03111	182	370	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MLLT1	Q03111	182	370	361	361	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MLLT1	Q03111	182	370	240	240	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MLLT1	Q03111	182	370	262	262	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MLLT1	Q03111	182	370	342	342	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MLLT1	Q03111	182	370	269	270	Sequence conflict	Note=KG->NP;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLLT1	Q03111	92	140	92	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J9S
MLLT1	Q03111	92	140	97	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J9S
MLLT1	Q03111	92	140	114	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J9S
MLLT1	Q03111	92	140	129	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J9S
MLLT1	Q03111	92	140	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J9S
MLLT1	Q03111	140	182	141	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J9S
ENOX2	Q16206	182	260	1	610	Chain	ID=PRO_0000079275;Note=Ecto-NOX disulfide-thiol exchanger 2
ENOX2	Q16206	113	182	1	610	Chain	ID=PRO_0000079275;Note=Ecto-NOX disulfide-thiol exchanger 2
ENOX2	Q16206	61	113	1	610	Chain	ID=PRO_0000079275;Note=Ecto-NOX disulfide-thiol exchanger 2
ENOX2	Q16206	182	260	1	610	Chain	ID=PRO_0000079275;Note=Ecto-NOX disulfide-thiol exchanger 2
ENOX2	Q16206	113	182	1	610	Chain	ID=PRO_0000079275;Note=Ecto-NOX disulfide-thiol exchanger 2
ENOX2	Q16206	61	113	1	610	Chain	ID=PRO_0000079275;Note=Ecto-NOX disulfide-thiol exchanger 2
ENOX2	Q16206	182	260	128	207	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
ENOX2	Q16206	113	182	128	207	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
ENOX2	Q16206	182	260	128	207	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
ENOX2	Q16206	113	182	128	207	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
ENOX2	Q16206	113	182	58	125	Compositional bias	Note=Pro-rich
ENOX2	Q16206	61	113	58	125	Compositional bias	Note=Pro-rich
ENOX2	Q16206	113	182	58	125	Compositional bias	Note=Pro-rich
ENOX2	Q16206	61	113	58	125	Compositional bias	Note=Pro-rich
ENOX2	Q16206	182	260	202	202	Natural variant	ID=VAR_069427;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs754363472,PMID:23033978
ENOX2	Q16206	182	260	202	202	Natural variant	ID=VAR_069427;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs754363472,PMID:23033978
ENOX2	Q16206	113	182	123	123	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENOX2	Q16206	113	182	123	123	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L3	Q9Y2J2	1024	1051	1	1087	Chain	ID=PRO_0000219399;Note=Band 4.1-like protein 3
EPB41L3	Q9Y2J2	991	1024	1	1087	Chain	ID=PRO_0000219399;Note=Band 4.1-like protein 3
EPB41L3	Q9Y2J2	947	991	1	1087	Chain	ID=PRO_0000219399;Note=Band 4.1-like protein 3
EPB41L3	Q9Y2J2	783	824	1	1087	Chain	ID=PRO_0000219399;Note=Band 4.1-like protein 3
EPB41L3	Q9Y2J2	707	719	1	1087	Chain	ID=PRO_0000219399;Note=Band 4.1-like protein 3
EPB41L3	Q9Y2J2	502	689	1	1087	Chain	ID=PRO_0000219399;Note=Band 4.1-like protein 3
EPB41L3	Q9Y2J2	1024	1051	2	1087	Chain	ID=PRO_0000423194;Note=Band 4.1-like protein 3%2C N-terminally processed
EPB41L3	Q9Y2J2	991	1024	2	1087	Chain	ID=PRO_0000423194;Note=Band 4.1-like protein 3%2C N-terminally processed
EPB41L3	Q9Y2J2	947	991	2	1087	Chain	ID=PRO_0000423194;Note=Band 4.1-like protein 3%2C N-terminally processed
EPB41L3	Q9Y2J2	783	824	2	1087	Chain	ID=PRO_0000423194;Note=Band 4.1-like protein 3%2C N-terminally processed
EPB41L3	Q9Y2J2	707	719	2	1087	Chain	ID=PRO_0000423194;Note=Band 4.1-like protein 3%2C N-terminally processed
EPB41L3	Q9Y2J2	502	689	2	1087	Chain	ID=PRO_0000423194;Note=Band 4.1-like protein 3%2C N-terminally processed
EPB41L3	Q9Y2J2	502	689	394	513	Region	Note=Hydrophilic
EPB41L3	Q9Y2J2	783	824	514	860	Region	Note=Spectrin--actin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPB41L3	Q9Y2J2	707	719	514	860	Region	Note=Spectrin--actin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPB41L3	Q9Y2J2	502	689	514	860	Region	Note=Spectrin--actin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPB41L3	Q9Y2J2	1024	1051	861	1083	Region	Note=C-terminal (CTD)
EPB41L3	Q9Y2J2	991	1024	861	1083	Region	Note=C-terminal (CTD)
EPB41L3	Q9Y2J2	947	991	861	1083	Region	Note=C-terminal (CTD)
EPB41L3	Q9Y2J2	707	719	708	708	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WV92
EPB41L3	Q9Y2J2	947	991	960	960	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WV92
EPB41L3	Q9Y2J2	947	991	962	962	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:24275569
EPB41L3	Q9Y2J2	502	689	503	689	Alternative sequence	ID=VSP_000483;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9892180;Dbxref=PMID:14702039,PMID:15489334,PMID:9892180
EPB41L3	Q9Y2J2	707	719	708	719	Alternative sequence	ID=VSP_000484;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9892180;Dbxref=PMID:15489334,PMID:9892180
EPB41L3	Q9Y2J2	783	824	784	824	Alternative sequence	ID=VSP_000485;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9892180;Dbxref=PMID:15489334,PMID:9892180
EPB41L3	Q9Y2J2	1024	1051	835	1087	Alternative sequence	ID=VSP_000486;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9892180;Dbxref=PMID:9892180
EPB41L3	Q9Y2J2	991	1024	835	1087	Alternative sequence	ID=VSP_000486;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9892180;Dbxref=PMID:9892180
EPB41L3	Q9Y2J2	947	991	835	1087	Alternative sequence	ID=VSP_000486;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9892180;Dbxref=PMID:9892180
EPB41L3	Q9Y2J2	502	689	555	555	Natural variant	ID=VAR_048353;Note=A->T;Dbxref=dbSNP:rs9966357
EPB41L3	Q9Y2J2	502	689	575	575	Natural variant	ID=VAR_048354;Note=Y->C;Dbxref=dbSNP:rs8082898
ECHS1	P30084	206	246	28	290	Chain	ID=PRO_0000007411;Note=Enoyl-CoA hydratase%2C mitochondrial
ECHS1	P30084	206	246	211	211	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BH95
ECHS1	P30084	206	246	225	225	Natural variant	ID=VAR_076195;Note=In ECHS1D. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26000322;Dbxref=dbSNP:rs769429279,PMID:26000322
ECHS1	P30084	206	246	210	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW5
ECHS1	P30084	206	246	215	217	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW5
ECHS1	P30084	206	246	218	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW5
ECHS1	P30084	206	246	234	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW5
ECHS1	P30084	206	246	246	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW5
ECHDC2	Q86YB7	251	267	36	292	Chain	ID=PRO_0000309459;Note=Enoyl-CoA hydratase domain-containing protein 2%2C mitochondrial
ECHDC2	Q86YB7	234	251	36	292	Chain	ID=PRO_0000309459;Note=Enoyl-CoA hydratase domain-containing protein 2%2C mitochondrial
ECHDC2	Q86YB7	152	171	36	292	Chain	ID=PRO_0000309459;Note=Enoyl-CoA hydratase domain-containing protein 2%2C mitochondrial
ECHDC2	Q86YB7	121	152	36	292	Chain	ID=PRO_0000309459;Note=Enoyl-CoA hydratase domain-containing protein 2%2C mitochondrial
ECHDC2	Q86YB7	92	121	36	292	Chain	ID=PRO_0000309459;Note=Enoyl-CoA hydratase domain-containing protein 2%2C mitochondrial
ECHDC2	Q86YB7	121	152	142	142	Site	Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
ECHDC2	Q86YB7	152	171	162	162	Site	Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
ECHDC2	Q86YB7	92	121	97	97	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TLP5
ECHDC2	Q86YB7	92	121	97	97	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TLP5
ECHDC2	Q86YB7	152	171	122	152	Alternative sequence	ID=VSP_029177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ECHDC2	Q86YB7	121	152	122	152	Alternative sequence	ID=VSP_029177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ECHDC2	Q86YB7	92	121	119	119	Natural variant	ID=VAR_036951;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854314,PMID:15489334
ECHDC2	Q86YB7	234	251	247	247	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
EDN2	P20800	115	147	70	178	Propeptide	ID=PRO_0000008095
EDN2	P20800	74	114	70	178	Propeptide	ID=PRO_0000008095
EDN2	P20800	74	114	96	111	Region	Note=Endothelin-like
EDN2	P20800	115	147	131	131	Natural variant	ID=VAR_033914;Note=F->L;Dbxref=dbSNP:rs5798
EFS	O43281	387	417	1	561	Chain	ID=PRO_0000086940;Note=Embryonal Fyn-associated substrate
EFS	O43281	99	146	1	561	Chain	ID=PRO_0000086940;Note=Embryonal Fyn-associated substrate
EFS	O43281	99	146	67	350	Compositional bias	Note=Pro-rich
EFS	O43281	99	146	7	99	Alternative sequence	ID=VSP_004232;Note=In isoform Efs2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9349509;Dbxref=PMID:14702039,PMID:15489334,PMID:9349509
EFS	O43281	99	146	100	100	Natural variant	ID=VAR_054089;Note=V->M;Dbxref=dbSNP:rs2231801
EFR3B	Q9Y2G0	574	618	1	817	Chain	ID=PRO_0000312295;Note=Protein EFR3 homolog B
EGFL6	Q8IUX8	62	93	22	553	Chain	ID=PRO_0000295811;Note=Epidermal growth factor-like protein 6
EGFL6	Q8IUX8	93	133	22	553	Chain	ID=PRO_0000295811;Note=Epidermal growth factor-like protein 6
EGFL6	Q8IUX8	133	173	22	553	Chain	ID=PRO_0000295811;Note=Epidermal growth factor-like protein 6
EGFL6	Q8IUX8	218	259	22	553	Chain	ID=PRO_0000295811;Note=Epidermal growth factor-like protein 6
EGFL6	Q8IUX8	62	93	65	91	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	93	133	94	133	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	133	173	94	133	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	133	173	137	173	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	218	259	219	259	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	93	133	98	109	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	93	133	105	118	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	93	133	120	132	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	218	259	223	236	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	218	259	230	245	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	218	259	247	258	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGFL6	Q8IUX8	62	93	66	66	Natural variant	ID=VAR_033366;Note=E->K;Dbxref=dbSNP:rs16979010
EGFL6	Q8IUX8	133	173	164	164	Natural variant	ID=VAR_033367;Note=R->C;Dbxref=dbSNP:rs34613284
EGFL6	Q8IUX8	62	93	83	83	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
EGFL6	Q8IUX8	133	173	134	134	Sequence conflict	Note=N->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
EGFL6	Q8IUX8	218	259	230	230	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF3CL	B5ME19	395	437	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3CL	B5ME19	119	161	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3CL	B5ME19	395	437	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3CL	B5ME19	119	161	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
ETNK2	Q9NVF9	173	213	1	386	Chain	ID=PRO_0000206229;Note=Ethanolamine kinase 2
ETNK2	Q9NVF9	173	213	173	213	Alternative sequence	ID=VSP_039558;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ENO2	P09104	222	288	2	434	Chain	ID=PRO_0000134112;Note=Gamma-enolase
ENO2	P09104	222	288	2	434	Chain	ID=PRO_0000134112;Note=Gamma-enolase
ENO2	P09104	222	288	2	434	Chain	ID=PRO_0000134112;Note=Gamma-enolase
ENO2	P09104	222	288	245	245	Metal binding	Note=Magnesium
ENO2	P09104	222	288	245	245	Metal binding	Note=Magnesium
ENO2	P09104	222	288	245	245	Metal binding	Note=Magnesium
ENO2	P09104	222	288	228	228	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	228	228	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	228	228	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	228	228	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17182
ENO2	P09104	222	288	228	228	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17182
ENO2	P09104	222	288	228	228	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17182
ENO2	P09104	222	288	233	233	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	233	233	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	233	233	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	256	256	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	256	256	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	256	256	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	263	263	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ENO2	P09104	222	288	263	263	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ENO2	P09104	222	288	263	263	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ENO2	P09104	222	288	287	287	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	287	287	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	287	287	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06733
ENO2	P09104	222	288	264	264	Natural variant	ID=VAR_002354;Note=P->A
ENO2	P09104	222	288	264	264	Natural variant	ID=VAR_002354;Note=P->A
ENO2	P09104	222	288	264	264	Natural variant	ID=VAR_002354;Note=P->A
ENO2	P09104	222	288	240	240	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENO2	P09104	222	288	240	240	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENO2	P09104	222	288	240	240	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENO2	P09104	222	288	240	240	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENO2	P09104	222	288	240	240	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENO2	P09104	222	288	240	240	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENO2	P09104	222	288	220	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	220	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	220	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	241	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	241	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	241	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	248	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	248	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	248	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	254	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKM
ENO2	P09104	222	288	254	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKM
ENO2	P09104	222	288	254	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKM
ENO2	P09104	222	288	259	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	259	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	259	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	273	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	273	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
ENO2	P09104	222	288	273	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AKZ
GSR	P00390	384	428	44	522	Chain	ID=PRO_0000030276;Note=Glutathione reductase%2C mitochondrial
GSR	P00390	294	347	44	522	Chain	ID=PRO_0000030276;Note=Glutathione reductase%2C mitochondrial
GSR	P00390	265	294	44	522	Chain	ID=PRO_0000030276;Note=Glutathione reductase%2C mitochondrial
GSR	P00390	294	347	266	294	Alternative sequence	ID=VSP_042908;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20628807;Dbxref=PMID:20628807
GSR	P00390	265	294	266	294	Alternative sequence	ID=VSP_042908;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20628807;Dbxref=PMID:20628807
GSR	P00390	294	347	295	347	Alternative sequence	ID=VSP_042909;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20628807;Dbxref=PMID:20628807
GSR	P00390	294	347	297	297	Natural variant	ID=VAR_019082;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs8191004
GSR	P00390	294	347	314	314	Natural variant	ID=VAR_014554;Note=P->H;Dbxref=dbSNP:rs2020916
GSR	P00390	265	294	262	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	265	294	272	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	265	294	288	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	294	347	293	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	265	294	293	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	294	347	302	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	294	347	319	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	294	347	335	338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	294	347	340	343	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GRS
GSR	P00390	294	347	344	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	384	428	383	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	384	428	413	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	384	428	417	419	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GSN
GSR	P00390	384	428	421	425	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
GSR	P00390	384	428	428	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DK9
E2F8	A0AVK6	150	255	1	867	Chain	ID=PRO_0000298909;Note=Transcription factor E2F8
E2F8	A0AVK6	150	255	1	867	Chain	ID=PRO_0000298909;Note=Transcription factor E2F8
E2F8	A0AVK6	150	255	113	182	DNA binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
E2F8	A0AVK6	150	255	113	182	DNA binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
E2F8	A0AVK6	150	255	156	156	Mutagenesis	Note=Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization%3B when associated with A-314. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15897886,ECO:0000269|PubMed:18202719;Dbxref=PMID:15897886,PMID:18202719
E2F8	A0AVK6	150	255	156	156	Mutagenesis	Note=Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization%3B when associated with A-314. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15897886,ECO:0000269|PubMed:18202719;Dbxref=PMID:15897886,PMID:18202719
E2F8	A0AVK6	150	255	154	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	154	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	169	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	169	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	186	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	186	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	199	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
E2F8	A0AVK6	150	255	199	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YO2
EAPP	Q56P03	157	193	1	285	Chain	ID=PRO_0000086904;Note=E2F-associated phosphoprotein
EAPP	Q56P03	85	117	1	285	Chain	ID=PRO_0000086904;Note=E2F-associated phosphoprotein
EAPP	Q56P03	85	117	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
EAPP	Q56P03	85	117	111	111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
EAPP	Q56P03	157	193	168	168	Natural variant	ID=VAR_031915;Note=Q->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15716352;Dbxref=dbSNP:rs17352411,PMID:15489334,PMID:15716352
HADHA	P40939	540	563	37	763	Chain	ID=PRO_0000007403;Note=Trifunctional enzyme subunit alpha%2C mitochondrial
HADHA	P40939	362	406	37	763	Chain	ID=PRO_0000007403;Note=Trifunctional enzyme subunit alpha%2C mitochondrial
HADHA	P40939	151	191	37	763	Chain	ID=PRO_0000007403;Note=Trifunctional enzyme subunit alpha%2C mitochondrial
HADHA	P40939	151	191	151	151	Site	Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
HADHA	P40939	151	191	173	173	Site	Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
HADHA	P40939	151	191	166	166	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMS1
HADHA	P40939	151	191	166	166	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMS1
HADHA	P40939	362	406	395	395	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
HADHA	P40939	362	406	399	399	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMS1
HADHA	P40939	362	406	406	406	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HADHA	P40939	362	406	406	406	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMS1
HADHA	P40939	540	563	540	540	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HADHA	P40939	540	563	83	763	Alternative sequence	ID=VSP_059011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HADHA	P40939	362	406	83	763	Alternative sequence	ID=VSP_059011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HADHA	P40939	151	191	83	763	Alternative sequence	ID=VSP_059011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HADHA	P40939	151	191	152	152	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
HADHA	P40939	151	191	171	171	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
HADHA	P40939	151	191	178	178	Sequence conflict	Note=A->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ECI1	P42126	98	147	42	302	Chain	ID=PRO_0000007420;Note=Enoyl-CoA delta isomerase 1%2C mitochondrial
ECI1	P42126	98	147	106	110	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1SG4,ECO:0000269|PubMed:15351645;Dbxref=PMID:15351645
ECI1	P42126	98	147	114	114	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ECI1	P42126	98	147	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SG4
ECI1	P42126	98	147	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SG4
ECI1	P42126	98	147	110	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SG4
ECI1	P42126	98	147	118	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SG4
ECI1	P42126	98	147	139	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SG4
EDEM1	Q92611	560	628	1	657	Chain	ID=PRO_0000210321;Note=ER degradation-enhancing alpha-mannosidase-like protein 1
EDEM1	Q92611	560	628	26	657	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EDEM1	Q92611	560	628	624	624	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EDEM1	Q92611	560	628	561	657	Alternative sequence	ID=VSP_056704;Note=In isoform 2. LFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFSEEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI->VCVLQDEPRNI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFCAB1	Q9HAE3	19	71	1	211	Chain	ID=PRO_0000251969;Note=EF-hand calcium-binding domain-containing protein 1
EFCAB1	Q9HAE3	19	71	64	99	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EFCAB1	Q9HAE3	19	71	20	20	Alternative sequence	ID=VSP_041330;Note=In isoform 2. F->L;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFCAB1	Q9HAE3	19	71	21	72	Alternative sequence	ID=VSP_041331;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFNA5	P52803	161	188	21	203	Chain	ID=PRO_0000008377;Note=Ephrin-A5
EFNA5	P52803	161	188	29	162	Domain	Note=Ephrin RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00884
EFNA5	P52803	161	188	161	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L0P
EFHD2	Q96C19	152	197	2	240	Chain	ID=PRO_0000073645;Note=EF-hand domain-containing protein D2
EFHD2	Q96C19	152	197	128	163	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EFHD2	Q96C19	152	197	141	152	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EFHD2	Q96C19	152	197	150	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I2L
EFHD2	Q96C19	152	197	170	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I2L
GRID2IP	A4D2P6	1021	1050	1	1211	Chain	ID=PRO_0000331624;Note=Delphilin
GRID2IP	A4D2P6	1021	1050	820	1211	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
GRIK3	Q13003	97	183	32	919	Chain	ID=PRO_0000011547;Note=Glutamate receptor ionotropic%2C kainate 3
GRIK3	Q13003	97	183	32	563	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK3	Q13003	97	183	99	350	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIK4	Q16099	27	82	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	230	248	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	248	302	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	388	424	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	424	492	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	567	624	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	27	82	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	230	248	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	248	302	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	388	424	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	424	492	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	567	624	21	956	Chain	ID=PRO_0000011549;Note=Glutamate receptor ionotropic%2C kainate 4
GRIK4	Q16099	27	82	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	230	248	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	388	424	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	424	492	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	27	82	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	230	248	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	388	424	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	424	492	21	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	567	624	567	623	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	567	624	567	623	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	567	624	624	644	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	567	624	624	644	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	272	272	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	272	272	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	286	286	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	286	286	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	388	424	408	408	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	388	424	408	408	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	388	424	415	415	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	388	424	415	415	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	424	492	479	479	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	424	492	479	479	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK4	Q16099	248	302	255	255	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GRIK4	Q16099	248	302	255	255	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GRIK5	Q16478	566	623	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	491	529	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	387	423	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	352	387	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	247	301	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	566	623	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	491	529	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	387	423	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	352	387	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	247	301	15	980	Chain	ID=PRO_0000011552;Note=Glutamate receptor ionotropic%2C kainate 5
GRIK5	Q16478	491	529	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	352	387	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	491	529	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	352	387	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	15	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	566	623	566	622	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	566	623	566	622	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	566	623	623	643	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	566	623	623	643	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	271	271	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	271	271	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	352	387	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	352	387	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	394	394	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	394	394	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	400	400	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	400	400	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	407	407	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	407	407	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	387	423	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK5	Q16478	247	301	36	292	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIK5	Q16478	247	301	36	292	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIK5	Q16478	247	301	83	334	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIK5	Q16478	247	301	83	334	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIP1	Q9Y3R0	1004	1053	1	1128	Chain	ID=PRO_0000083849;Note=Glutamate receptor-interacting protein 1
GRIP1	Q9Y3R0	911	926	1	1128	Chain	ID=PRO_0000083849;Note=Glutamate receptor-interacting protein 1
GRIP1	Q9Y3R0	347	399	1	1128	Chain	ID=PRO_0000083849;Note=Glutamate receptor-interacting protein 1
GRIP1	Q9Y3R0	139	167	1	1128	Chain	ID=PRO_0000083849;Note=Glutamate receptor-interacting protein 1
GRIP1	Q9Y3R0	139	167	150	238	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
GRIP1	Q9Y3R0	1004	1053	1004	1086	Domain	Note=PDZ 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
GRIP1	Q9Y3R0	347	399	348	400	Alternative sequence	ID=VSP_040281;Note=In isoform 3. VKIQRSDRQLTWDSWASNHSSLHTNHHYNTYHPDHCRVPALTFPKAPPPNSPP->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GRIP1	Q9Y3R0	911	926	912	926	Alternative sequence	ID=VSP_009743;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10197531;Dbxref=PMID:10197531
GRIP1	Q9Y3R0	139	167	148	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIL
GRIP1	Q9Y3R0	139	167	163	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIL
GRAMD1A	Q96CP6	356	404	1	724	Chain	ID=PRO_0000287446;Note=GRAM domain-containing protein 1A
GRAMD1A	Q96CP6	356	404	367	538	Domain	Note=VASt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01114
EHD4	Q9H223	308	363	1	541	Chain	ID=PRO_0000146114;Note=EH domain-containing protein 4
DPH7	Q9BTV6	237	258	1	452	Chain	ID=PRO_0000050906;Note=Diphthine methyltransferase
DPH7	Q9BTV6	237	258	230	273	Repeat	Note=WD 4
POLB	P06746	62	87	1	335	Chain	ID=PRO_0000218778;Note=DNA polymerase beta
POLB	P06746	207	236	1	335	Chain	ID=PRO_0000218778;Note=DNA polymerase beta
POLB	P06746	62	87	72	72	Active site	Note=Schiff-base intermediate with DNA
POLB	P06746	62	87	72	72	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K409
POLB	P06746	62	87	83	83	Modified residue	Note=Omega-N-methylarginine%3B by PRMT6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16600869;Dbxref=PMID:16600869
POLB	P06746	62	87	81	81	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19713937,ECO:0000269|PubMed:21362556;Dbxref=PMID:19713937,PMID:21362556
POLB	P06746	62	87	68	68	Mutagenesis	Note=Reduces DNA lyase activity slightly. K->Q%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9572863;Dbxref=PMID:9572863
POLB	P06746	62	87	72	72	Mutagenesis	Note=Abolishes DNA lyase activity. No effect on DNA polymerase activity. K->Q%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9572863;Dbxref=PMID:9572863
POLB	P06746	62	87	81	81	Mutagenesis	Note=Abolishes ubiquitination%3B when associated with R-41 and R-61. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19713937;Dbxref=PMID:19713937
POLB	P06746	62	87	83	83	Mutagenesis	Note=Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity%3B when associated with K-152. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16600869;Dbxref=PMID:16600869
POLB	P06746	62	87	84	84	Mutagenesis	Note=No effect. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9572863;Dbxref=PMID:9572863
POLB	P06746	207	236	228	228	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLB	P06746	62	87	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BPY
POLB	P06746	62	87	67	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLI
POLB	P06746	62	87	83	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLI
POLB	P06746	207	236	207	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLL
POLB	P06746	207	236	210	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLI
POLB	P06746	207	236	224	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLI
POLB	P06746	207	236	232	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLI
POLL	Q9UGP5	355	398	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	297	355	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	191	297	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	355	398	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	297	355	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	191	297	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	355	398	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	297	355	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	191	297	1	575	Chain	ID=PRO_0000218783;Note=DNA polymerase lambda
POLL	Q9UGP5	191	297	265	279	Region	Note=DNA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14992725;Dbxref=PMID:14992725
POLL	Q9UGP5	191	297	265	279	Region	Note=DNA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14992725;Dbxref=PMID:14992725
POLL	Q9UGP5	191	297	265	279	Region	Note=DNA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14992725;Dbxref=PMID:14992725
POLL	Q9UGP5	297	355	345	348	Region	Note=DNA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14992725;Dbxref=PMID:14992725
POLL	Q9UGP5	297	355	345	348	Region	Note=DNA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14992725;Dbxref=PMID:14992725
POLL	Q9UGP5	297	355	345	348	Region	Note=DNA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14992725;Dbxref=PMID:14992725
POLL	Q9UGP5	297	355	312	312	Active site	Note=Schiff-base intermediate with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11457865;Dbxref=PMID:11457865
POLL	Q9UGP5	297	355	312	312	Active site	Note=Schiff-base intermediate with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11457865;Dbxref=PMID:11457865
POLL	Q9UGP5	297	355	312	312	Active site	Note=Schiff-base intermediate with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11457865;Dbxref=PMID:11457865
POLL	Q9UGP5	355	398	386	386	Binding site	Note=dCTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2PFP,ECO:0000244|PDB:2PFQ,ECO:0000269|PubMed:17475573;Dbxref=PMID:17475573
POLL	Q9UGP5	355	398	386	386	Binding site	Note=dCTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2PFP,ECO:0000244|PDB:2PFQ,ECO:0000269|PubMed:17475573;Dbxref=PMID:17475573
POLL	Q9UGP5	355	398	386	386	Binding site	Note=dCTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2PFP,ECO:0000244|PDB:2PFQ,ECO:0000269|PubMed:17475573;Dbxref=PMID:17475573
POLL	Q9UGP5	297	355	23	297	Alternative sequence	ID=VSP_056541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLL	Q9UGP5	191	297	23	297	Alternative sequence	ID=VSP_056541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLL	Q9UGP5	297	355	23	297	Alternative sequence	ID=VSP_056541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLL	Q9UGP5	191	297	23	297	Alternative sequence	ID=VSP_056541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLL	Q9UGP5	297	355	23	297	Alternative sequence	ID=VSP_056541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLL	Q9UGP5	191	297	23	297	Alternative sequence	ID=VSP_056541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLL	Q9UGP5	191	297	221	221	Natural variant	ID=VAR_020268;Note=T->P;Dbxref=dbSNP:rs3730463
POLL	Q9UGP5	191	297	221	221	Natural variant	ID=VAR_020268;Note=T->P;Dbxref=dbSNP:rs3730463
POLL	Q9UGP5	191	297	221	221	Natural variant	ID=VAR_020268;Note=T->P;Dbxref=dbSNP:rs3730463
POLL	Q9UGP5	297	355	312	312	Mutagenesis	Note=Reduces dRP lyase activity by over 90%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11457865;Dbxref=PMID:11457865
POLL	Q9UGP5	297	355	312	312	Mutagenesis	Note=Reduces dRP lyase activity by over 90%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11457865;Dbxref=PMID:11457865
POLL	Q9UGP5	297	355	312	312	Mutagenesis	Note=Reduces dRP lyase activity by over 90%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11457865;Dbxref=PMID:11457865
POLL	Q9UGP5	297	355	298	298	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLL	Q9UGP5	297	355	298	298	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLL	Q9UGP5	297	355	298	298	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLL	Q9UGP5	191	297	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NZP
POLL	Q9UGP5	191	297	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NZP
POLL	Q9UGP5	191	297	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NZP
POLL	Q9UGP5	191	297	254	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	254	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	254	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	273	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	273	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	273	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HW8
POLL	Q9UGP5	191	297	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HW8
POLL	Q9UGP5	191	297	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HW8
POLL	Q9UGP5	191	297	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MGI
POLL	Q9UGP5	191	297	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MGI
POLL	Q9UGP5	191	297	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MGI
POLL	Q9UGP5	297	355	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	191	297	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	307	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	307	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	307	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	323	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	323	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	323	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	332	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	332	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	332	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	346	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	346	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	297	355	346	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	360	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	360	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	360	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	371	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	371	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	371	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	379	381	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	379	381	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	379	381	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	382	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	382	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	382	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	389	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	389	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLL	Q9UGP5	355	398	389	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BCQ
POLG2	Q9UHN1	323	370	325	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKL
POLG2	Q9UHN1	323	370	334	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKL
POLG2	Q9UHN1	323	370	342	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKL
POLG2	Q9UHN1	323	370	359	361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG2	Q9UHN1	323	370	362	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG2	Q9UHN1	370	397	376	378	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKL
POLG2	Q9UHN1	370	397	379	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG2	Q9UHN1	370	397	383	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKL
POLG2	Q9UHN1	370	397	395	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKL
POLE	Q07864	2219	2249	1	2286	Chain	ID=PRO_0000046455;Note=DNA polymerase epsilon catalytic subunit A
POLE	Q07864	369	408	1	2286	Chain	ID=PRO_0000046455;Note=DNA polymerase epsilon catalytic subunit A
POLE	Q07864	95	110	1	2286	Chain	ID=PRO_0000046455;Note=DNA polymerase epsilon catalytic subunit A
POLE	Q07864	68	95	1	2286	Chain	ID=PRO_0000046455;Note=DNA polymerase epsilon catalytic subunit A
POLE	Q07864	2219	2249	2221	2238	Motif	Note=CysB motif
POLE	Q07864	2219	2249	2221	2221	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLE	Q07864	2219	2249	2224	2224	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLE	Q07864	2219	2249	2236	2236	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLE	Q07864	2219	2249	2238	2238	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLE	Q07864	95	110	99	99	Natural variant	ID=VAR_028429;Note=P->L;Dbxref=dbSNP:rs5744739
POLE	Q07864	2219	2249	2237	2237	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLE	Q07864	2219	2249	2237	2237	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLE	Q07864	2219	2249	2219	2224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE	Q07864	2219	2249	2230	2232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE	Q07864	2219	2249	2237	2239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE	Q07864	2219	2249	2241	2246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE	Q07864	2219	2249	2248	2265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
DPP4	P27487	415	432	1	766	Chain	ID=PRO_0000027213;Note=Dipeptidyl peptidase 4 membrane form
DPP4	P27487	31	64	1	766	Chain	ID=PRO_0000027213;Note=Dipeptidyl peptidase 4 membrane form
DPP4	P27487	415	432	39	766	Chain	ID=PRO_0000027214;Note=Dipeptidyl peptidase 4 soluble form
DPP4	P27487	31	64	39	766	Chain	ID=PRO_0000027214;Note=Dipeptidyl peptidase 4 soluble form
DPP4	P27487	415	432	29	766	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPP4	P27487	31	64	29	766	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPP4	P27487	31	64	40	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VJM
DPP4	P27487	31	64	45	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S
DPP4	P27487	31	64	60	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S
DPP4	P27487	31	64	64	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S
DPP4	P27487	415	432	412	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S
DPP4	P27487	415	432	422	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S
DPP4	P27487	415	432	429	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S
PDSS1	Q5T2R2	342	369	1	415	Chain	ID=PRO_0000123975;Note=Decaprenyl-diphosphate synthase subunit 1
PDSS1	Q5T2R2	342	369	279	415	Alternative sequence	ID=VSP_017101;Note=In isoform 2. SVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGLATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHEAIREISKLRPSPERDALIQLSEIVLTRDK->FPRNECYDHATVQFAWRCRQSSTVCTTE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DRAM1	Q8N682	193	224	1	238	Chain	ID=PRO_0000287436;Note=DNA damage-regulated autophagy modulator protein 1
DRAM1	Q8N682	193	224	200	220	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DRAM1	Q8N682	193	224	113	222	Alternative sequence	ID=VSP_056980;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC65	Q8IXS2	269	342	1	484	Chain	ID=PRO_0000284778;Note=Dynein regulatory complex subunit 2
CCDC65	Q8IXS2	269	342	308	308	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHRS7B	Q6IAN0	175	206	1	325	Chain	ID=PRO_0000312105;Note=Dehydrogenase/reductase SDR family member 7B
DHRS7B	Q6IAN0	206	257	1	325	Chain	ID=PRO_0000312105;Note=Dehydrogenase/reductase SDR family member 7B
DHRS7B	Q6IAN0	175	206	39	325	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DHRS7B	Q6IAN0	206	257	39	325	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DHRS7B	Q6IAN0	206	257	207	207	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
DHRS7B	Q6IAN0	175	206	194	194	Binding site	Note=Substrate;Ontology_term=ECO:0000255;evidence=ECO:0000255
DHRS7B	Q6IAN0	206	257	210	210	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHRS7B	Q6IAN0	206	257	256	256	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
DTL	Q9NZJ0	59	92	1	730	Chain	ID=PRO_0000274867;Note=Denticleless protein homolog
DTL	Q9NZJ0	153	175	1	730	Chain	ID=PRO_0000274867;Note=Denticleless protein homolog
DTL	Q9NZJ0	59	92	47	89	Repeat	Note=WD 1
DTL	Q9NZJ0	153	175	138	178	Repeat	Note=WD 3
DTL	Q9NZJ0	153	175	168	171	Motif	Note=DDB1-binding motif
DTL	Q9NZJ0	59	92	18	59	Alternative sequence	ID=VSP_022879;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DTL	Q9NZJ0	59	92	83	83	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DTX3L	Q8TDB6	133	645	2	740	Chain	ID=PRO_0000219087;Note=E3 ubiquitin-protein ligase DTX3L
DTX3L	Q8TDB6	133	645	561	600	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
DTX3L	Q8TDB6	133	645	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
DTX3L	Q8TDB6	133	645	221	221	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DTX3L	Q8TDB6	133	645	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
DTX3L	Q8TDB6	133	645	539	539	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
DTX3L	Q8TDB6	133	645	134	645	Alternative sequence	ID=VSP_038522;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DTX3L	Q8TDB6	133	645	209	209	Natural variant	ID=VAR_036098;Note=In a breast cancer sample%3B somatic mutation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
DTX3L	Q8TDB6	133	645	425	425	Natural variant	ID=VAR_048895;Note=R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2332285,PMID:14702039
DTX3L	Q8TDB6	133	645	561	564	Mutagenesis	Note=Loss of catalytic activity. Loss of histone H2B ubiquitination. No effect on STAT1 phosphorylation and on the interaction with PARP9 and STAT1. CVIC->SVIS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26479788;Dbxref=PMID:26479788
DTX3L	Q8TDB6	133	645	561	561	Mutagenesis	Note=Loss of catalytic activity but does not affect its capacity to inhibit ITCH catalytic activity%3B when associated with A-596 and A-599. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24790097;Dbxref=PMID:24790097
DTX3L	Q8TDB6	133	645	596	596	Mutagenesis	Note=Loss of catalytic activity but does not affect its capacity to inhibit ITCH catalytic activity%3B when associated with A-561 and A-599. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24790097;Dbxref=PMID:24790097
DTX3L	Q8TDB6	133	645	599	599	Mutagenesis	Note=Loss of catalytic activity but does not affect its capacity to inhibit ITCH catalytic activity%3B when associated with A-561 and A-596. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24790097;Dbxref=PMID:24790097
DTX3L	Q8TDB6	133	645	612	622	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PG6
DTX3L	Q8TDB6	133	645	630	639	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PG6
DUS2	Q9NX74	123	139	1	493	Chain	ID=PRO_0000162157;Note=tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
DUS2	Q9NX74	311	360	1	493	Chain	ID=PRO_0000162157;Note=tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
DUS2	Q9NX74	123	139	1	493	Chain	ID=PRO_0000162157;Note=tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
DUS2	Q9NX74	311	360	1	493	Chain	ID=PRO_0000162157;Note=tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
DUS2	Q9NX74	123	139	130	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	123	139	130	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	123	139	134	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	123	139	134	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	307	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	307	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	317	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	317	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	336	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	336	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XP7
DUS2	Q9NX74	311	360	351	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WFT
DUS2	Q9NX74	311	360	351	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WFT
E2F7	Q96AV8	329	374	1	911	Chain	ID=PRO_0000298907;Note=Transcription factor E2F7
E2F7	Q96AV8	329	374	282	367	DNA binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
E2F7	Q96AV8	329	374	334	334	Mutagenesis	Note=Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization%3B when associated with A-185. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15133492,ECO:0000269|PubMed:18202719;Dbxref=PMID:15133492,PMID:18202719
EIF2AK3	Q9NZJ5	995	1029	30	1116	Chain	ID=PRO_0000024322;Note=Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3	Q9NZJ5	939	995	30	1116	Chain	ID=PRO_0000024322;Note=Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3	Q9NZJ5	146	211	30	1116	Chain	ID=PRO_0000024322;Note=Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3	Q9NZJ5	146	211	30	514	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF2AK3	Q9NZJ5	995	1029	536	1116	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF2AK3	Q9NZJ5	939	995	536	1116	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF2AK3	Q9NZJ5	995	1029	593	1077	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK3	Q9NZJ5	939	995	593	1077	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK3	Q9NZJ5	939	995	982	982	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2B5
EIF2AK3	Q9NZJ5	146	211	166	166	Natural variant	ID=VAR_011410;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10026192,ECO:0000269|PubMed:10677345,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs13045,PMID:10026192,PMID:10677345,PMID:15489334
EIF2AK3	Q9NZJ5	146	211	152	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	166	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	171	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	178	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	193	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	207	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	939	995	940	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	939	995	943	945	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	939	995	951	953	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	995	1029	993	996	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	939	995	993	996	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	995	1029	1004	1018	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	995	1029	1024	1035	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
ECT2L	Q008S8	399	430	1	904	Chain	ID=PRO_0000336075;Note=Epithelial cell-transforming sequence 2 oncogene-like
ECT2L	Q008S8	526	555	1	904	Chain	ID=PRO_0000336075;Note=Epithelial cell-transforming sequence 2 oncogene-like
ECT2L	Q008S8	399	430	1	904	Chain	ID=PRO_0000336075;Note=Epithelial cell-transforming sequence 2 oncogene-like
ECT2L	Q008S8	526	555	1	904	Chain	ID=PRO_0000336075;Note=Epithelial cell-transforming sequence 2 oncogene-like
ECT2L	Q008S8	330	361	1	904	Chain	ID=PRO_0000336075;Note=Epithelial cell-transforming sequence 2 oncogene-like
ECT2L	Q008S8	457	486	1	904	Chain	ID=PRO_0000336075;Note=Epithelial cell-transforming sequence 2 oncogene-like
ECT2L	Q008S8	457	486	483	483	Natural variant	ID=VAR_051984;Note=Q->H;Dbxref=dbSNP:rs12198781
ECT2L	Q008S8	526	555	527	527	Natural variant	ID=VAR_043482;Note=E->K;Dbxref=dbSNP:rs1529151
ECT2L	Q008S8	526	555	527	527	Natural variant	ID=VAR_043482;Note=E->K;Dbxref=dbSNP:rs1529151
ECT2L	Q008S8	457	486	472	472	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ECT2	Q9H8V3	70	101	2	914	Chain	ID=PRO_0000080938;Note=Protein ECT2
ECT2	Q9H8V3	192	228	2	914	Chain	ID=PRO_0000080938;Note=Protein ECT2
ECT2	Q9H8V3	192	228	171	260	Domain	Note=BRCT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033
ECT2	Q9H8V3	70	101	71	101	Alternative sequence	ID=VSP_041977;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10579713,ECO:0000303|PubMed:14587037,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10579713,PMID:14587037,PMID:14702039,PMID:15489334
ECT2	Q9H8V3	192	228	226	226	Mutagenesis	Note=Inhibits interaction with RACGAP1. Abolishes targeting to the central spindle. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19468300;Dbxref=PMID:19468300
ECT2	Q9H8V3	70	101	63	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N40
ECT2	Q9H8V3	192	228	189	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N40
ECT2	Q9H8V3	192	228	201	203	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N40
ECT2	Q9H8V3	192	228	218	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N40
ECT2	Q9H8V3	192	228	225	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N40
EEF1A1	P68104	48	108	2	462	Chain	ID=PRO_0000090885;Note=Elongation factor 1-alpha 1
EEF1A1	P68104	48	108	2	462	Chain	ID=PRO_0000090885;Note=Elongation factor 1-alpha 1
EEF1A1	P68104	48	108	5	242	Domain	Note=tr-type G
EEF1A1	P68104	48	108	5	242	Domain	Note=tr-type G
EEF1A1	P68104	48	108	91	95	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	91	95	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	70	74	Region	Note=G2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	70	74	Region	Note=G2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	91	94	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	91	94	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	55	55	Modified residue	Note=N6%2CN6-dimethyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7
EEF1A1	P68104	48	108	55	55	Modified residue	Note=N6%2CN6-dimethyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7
EEF1A1	P68104	48	108	79	79	Modified residue	Note=N6%2CN6%2CN6-trimethyllysine%3B by EEF1AKMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26545399;Dbxref=PMID:26545399
EEF1A1	P68104	48	108	79	79	Modified residue	Note=N6%2CN6%2CN6-trimethyllysine%3B by EEF1AKMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26545399;Dbxref=PMID:26545399
EEF1A1	P68104	48	108	55	55	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	55	55	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	79	79	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	79	79	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	83	83	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1A1	P68104	48	108	83	83	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEPD1	Q7L9B9	310	347	2	569	Chain	ID=PRO_0000317261;Note=Endonuclease/exonuclease/phosphatase family domain-containing protein 1
EEPD1	Q7L9B9	347	392	2	569	Chain	ID=PRO_0000317261;Note=Endonuclease/exonuclease/phosphatase family domain-containing protein 1
EEPD1	Q7L9B9	438	503	2	569	Chain	ID=PRO_0000317261;Note=Endonuclease/exonuclease/phosphatase family domain-containing protein 1
EEPD1	Q7L9B9	310	347	2	569	Chain	ID=PRO_0000317261;Note=Endonuclease/exonuclease/phosphatase family domain-containing protein 1
EEPD1	Q7L9B9	347	392	2	569	Chain	ID=PRO_0000317261;Note=Endonuclease/exonuclease/phosphatase family domain-containing protein 1
EEPD1	Q7L9B9	438	503	2	569	Chain	ID=PRO_0000317261;Note=Endonuclease/exonuclease/phosphatase family domain-containing protein 1
EEPD1	Q7L9B9	310	347	343	343	Natural variant	ID=VAR_060374;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214970,ECO:0000269|PubMed:12690205,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs196586,PMID:11214970,PMID:12690205,PMID:14702039,PMID:15489334
EEPD1	Q7L9B9	310	347	343	343	Natural variant	ID=VAR_060374;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214970,ECO:0000269|PubMed:12690205,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs196586,PMID:11214970,PMID:12690205,PMID:14702039,PMID:15489334
EEPD1	Q7L9B9	347	392	358	358	Natural variant	ID=VAR_056867;Note=A->S;Dbxref=dbSNP:rs3815682
EEPD1	Q7L9B9	347	392	358	358	Natural variant	ID=VAR_056867;Note=A->S;Dbxref=dbSNP:rs3815682
RASGRP3	Q8IV61	79	122	1	690	Chain	ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3
RASGRP3	Q8IV61	361	387	1	690	Chain	ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3
RASGRP3	Q8IV61	387	426	1	690	Chain	ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3
RASGRP3	Q8IV61	79	122	1	690	Chain	ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3
RASGRP3	Q8IV61	361	387	1	690	Chain	ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3
RASGRP3	Q8IV61	387	426	1	690	Chain	ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3
RASGRP3	Q8IV61	79	122	3	125	Domain	Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135
RASGRP3	Q8IV61	79	122	3	125	Domain	Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135
RASGRP3	Q8IV61	361	387	152	383	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RASGRP3	Q8IV61	361	387	152	383	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RASGRP3	Q8IV61	387	426	420	455	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RASGRP3	Q8IV61	387	426	420	455	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RASGRP3	Q8IV61	387	426	388	388	Alternative sequence	ID=VSP_047371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10048485;Dbxref=PMID:10048485
RASGRP3	Q8IV61	387	426	388	388	Alternative sequence	ID=VSP_047371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10048485;Dbxref=PMID:10048485
RASGRP3	Q8IV61	387	426	393	393	Natural variant	ID=VAR_051901;Note=T->A;Dbxref=dbSNP:rs13388394
RASGRP3	Q8IV61	387	426	393	393	Natural variant	ID=VAR_051901;Note=T->A;Dbxref=dbSNP:rs13388394
EHF	Q9NZC4	32	114	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	114	135	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	158	181	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	181	202	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	32	114	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	114	135	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	158	181	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	181	202	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	32	114	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	114	135	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	158	181	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	181	202	1	300	Chain	ID=PRO_0000257969;Note=ETS homologous factor
EHF	Q9NZC4	32	114	29	115	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
EHF	Q9NZC4	114	135	29	115	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
EHF	Q9NZC4	32	114	29	115	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
EHF	Q9NZC4	114	135	29	115	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
EHF	Q9NZC4	32	114	29	115	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
EHF	Q9NZC4	114	135	29	115	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
EHF	Q9NZC4	158	181	159	181	Alternative sequence	ID=VSP_052190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644770;Dbxref=PMID:10644770
EHF	Q9NZC4	181	202	159	181	Alternative sequence	ID=VSP_052190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644770;Dbxref=PMID:10644770
EHF	Q9NZC4	158	181	159	181	Alternative sequence	ID=VSP_052190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644770;Dbxref=PMID:10644770
EHF	Q9NZC4	181	202	159	181	Alternative sequence	ID=VSP_052190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644770;Dbxref=PMID:10644770
EHF	Q9NZC4	158	181	159	181	Alternative sequence	ID=VSP_052190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644770;Dbxref=PMID:10644770
EHF	Q9NZC4	181	202	159	181	Alternative sequence	ID=VSP_052190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644770;Dbxref=PMID:10644770
EHF	Q9NZC4	32	114	96	96	Natural variant	ID=VAR_048941;Note=A->V;Dbxref=dbSNP:rs9804460
EHF	Q9NZC4	32	114	96	96	Natural variant	ID=VAR_048941;Note=A->V;Dbxref=dbSNP:rs9804460
EHF	Q9NZC4	32	114	96	96	Natural variant	ID=VAR_048941;Note=A->V;Dbxref=dbSNP:rs9804460
EHF	Q9NZC4	32	114	40	40	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	32	114	40	40	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	32	114	40	40	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	32	114	40	40	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	32	114	40	40	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	32	114	40	40	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	158	181	163	163	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	158	181	163	163	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	158	181	163	163	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	158	181	169	169	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	158	181	169	169	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	158	181	169	169	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	181	202	196	196	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	181	202	196	196	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHF	Q9NZC4	181	202	196	196	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF3B	P55884	386	429	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	718	744	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	386	429	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	718	744	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	386	429	366	425	Repeat	Note=WD 3
EIF3B	P55884	386	429	366	425	Repeat	Note=WD 3
EIF3B	P55884	386	429	426	489	Repeat	Note=WD 4
EIF3B	P55884	386	429	426	489	Repeat	Note=WD 4
EIF3B	P55884	386	429	124	413	Region	Note=Sufficient for interaction with EIF3E
EIF3B	P55884	386	429	124	413	Region	Note=Sufficient for interaction with EIF3E
EIF3H	O15372	186	235	1	352	Chain	ID=PRO_0000213961;Note=Eukaryotic translation initiation factor 3 subunit H
EIF3H	O15372	96	152	1	352	Chain	ID=PRO_0000213961;Note=Eukaryotic translation initiation factor 3 subunit H
EIF3H	O15372	96	152	39	173	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
EIF3H	O15372	96	152	97	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	96	152	115	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	96	152	132	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	96	152	148	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	197	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	203	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	209	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	216	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
ELAVL2	Q12926	238	250	1	359	Chain	ID=PRO_0000081579;Note=ELAV-like protein 2
ELAVL2	Q12926	238	250	1	359	Chain	ID=PRO_0000081579;Note=ELAV-like protein 2
ELAVL2	Q12926	238	250	1	359	Chain	ID=PRO_0000081579;Note=ELAV-like protein 2
ELAVL2	Q12926	238	250	239	251	Alternative sequence	ID=VSP_005788;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7972035;Dbxref=PMID:15489334,PMID:7972035
ELAVL2	Q12926	238	250	239	251	Alternative sequence	ID=VSP_005788;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7972035;Dbxref=PMID:15489334,PMID:7972035
ELAVL2	Q12926	238	250	239	251	Alternative sequence	ID=VSP_005788;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7972035;Dbxref=PMID:15489334,PMID:7972035
E2F4	Q16254	360	375	2	413	Chain	ID=PRO_0000219468;Note=Transcription factor E2F4
E2F4	Q16254	360	375	337	413	Region	Note=Transactivation;Ontology_term=ECO:0000255;evidence=ECO:0000255
DZIP1L	Q8IYY4	354	401	1	767	Chain	ID=PRO_0000331306;Note=Zinc finger protein DZIP1L
DZIP1L	Q8IYY4	354	401	205	406	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DZIP1L	Q8IYY4	354	401	155	767	Natural variant	ID=VAR_078964;Note=In PKD5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28530676;Dbxref=PMID:28530676
DZIP1L	Q8IYY4	354	401	382	382	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
EHHADH	Q08426	154	189	1	723	Chain	ID=PRO_0000109247;Note=Peroxisomal bifunctional enzyme
EHHADH	Q08426	154	189	1	282	Region	Note=Enoyl-CoA hydratase / isomerase
EHHADH	Q08426	154	189	165	165	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
EHHADH	Q08426	154	189	165	165	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBM2
EHHADH	Q08426	154	189	171	171	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
EHHADH	Q08426	154	189	165	165	Mutagenesis	Note=Greatly reduced acetylation and insensitive to treatment with TSA and NAM%3B when associated with Q-171%3B Q-346 and Q-584. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
EHHADH	Q08426	154	189	171	171	Mutagenesis	Note=Greatly reduced acetylation and insensitive to treatment with TSA and NAM%3B when associated with Q-165%3B Q-346 and Q-584. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
EDC3	Q96F86	161	273	1	508	Chain	ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3
EDC3	Q96F86	161	273	1	508	Chain	ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3
EDC3	Q96F86	161	273	1	508	Chain	ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3
EDC3	Q96F86	161	273	192	228	Domain	Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845
EDC3	Q96F86	161	273	192	228	Domain	Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845
EDC3	Q96F86	161	273	192	228	Domain	Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845
EDC3	Q96F86	161	273	191	296	Region	Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250
EDC3	Q96F86	161	273	191	296	Region	Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250
EDC3	Q96F86	161	273	191	296	Region	Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250
EDC3	Q96F86	161	273	161	161	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
EDC3	Q96F86	161	273	161	161	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
EDC3	Q96F86	161	273	161	161	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
EDC3	Q96F86	161	273	204	204	Mutagenesis	Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
EDC3	Q96F86	161	273	204	204	Mutagenesis	Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
EDC3	Q96F86	161	273	204	204	Mutagenesis	Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
EDC3	Q96F86	161	273	206	206	Mutagenesis	Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
EDC3	Q96F86	161	273	206	206	Mutagenesis	Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
EDC3	Q96F86	161	273	206	206	Mutagenesis	Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
EDC3	Q96F86	161	273	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX
EDC3	Q96F86	161	273	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX
EDC3	Q96F86	161	273	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX
EDC3	Q96F86	161	273	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX
EDC3	Q96F86	161	273	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX
EDC3	Q96F86	161	273	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX
EDC3	Q96F86	161	273	270	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K
EDC3	Q96F86	161	273	270	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K
EDC3	Q96F86	161	273	270	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K
EFCAB10	A6NFE3	35	90	1	127	Chain	ID=PRO_0000340680;Note=EF-hand calcium-binding domain-containing protein 10
EFCAB10	A6NFE3	35	90	63	98	Domain	Note=EF-hand;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EFCAB13	Q8IY85	172	220	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	220	268	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	268	292	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	503	527	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	527	575	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	759	807	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	831	879	1	973	Chain	ID=PRO_0000281110;Note=EF-hand calcium-binding domain-containing protein 13
EFCAB13	Q8IY85	503	527	488	523	Domain	Note=EF-hand 1
EFCAB13	Q8IY85	503	527	524	559	Domain	Note=EF-hand 2
EFCAB13	Q8IY85	527	575	524	559	Domain	Note=EF-hand 2
EFCAB13	Q8IY85	759	807	756	791	Domain	Note=EF-hand 4
EFCAB13	Q8IY85	759	807	792	827	Domain	Note=EF-hand 5
EFCAB13	Q8IY85	831	879	864	899	Domain	Note=EF-hand 6
EFCAB13	Q8IY85	172	220	173	269	Alternative sequence	ID=VSP_047187;Note=In isoform 2. ALHKACKIFSKIRSGKIYVNDLPVILCILRISISDLEMRQALKTVDIDAFQDALKIFCRIKGGRVSTDDVFAVLDSMGIPINREILEEVTKHTYIDS->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EFCAB13	Q8IY85	220	268	173	269	Alternative sequence	ID=VSP_047187;Note=In isoform 2. ALHKACKIFSKIRSGKIYVNDLPVILCILRISISDLEMRQALKTVDIDAFQDALKIFCRIKGGRVSTDDVFAVLDSMGIPINREILEEVTKHTYIDS->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EFCAB13	Q8IY85	268	292	173	269	Alternative sequence	ID=VSP_047187;Note=In isoform 2. ALHKACKIFSKIRSGKIYVNDLPVILCILRISISDLEMRQALKTVDIDAFQDALKIFCRIKGGRVSTDDVFAVLDSMGIPINREILEEVTKHTYIDS->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EFCAB13	Q8IY85	268	292	279	279	Natural variant	ID=VAR_061091;Note=I->V;Dbxref=dbSNP:rs55853213
EFCAB13	Q8IY85	268	292	286	286	Natural variant	ID=VAR_035465;Note=In a breast cancer sample%3B somatic mutation. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
EFCAB14	O75071	265	329	1	495	Chain	ID=PRO_0000073882;Note=EF-hand calcium-binding domain-containing protein 14
EFCAB14	O75071	160	193	1	495	Chain	ID=PRO_0000073882;Note=EF-hand calcium-binding domain-containing protein 14
EEF2	P13639	689	750	2	858	Chain	ID=PRO_0000091000;Note=Elongation factor 2
EEF2	P13639	571	689	2	858	Chain	ID=PRO_0000091000;Note=Elongation factor 2
EEF2	P13639	299	337	2	858	Chain	ID=PRO_0000091000;Note=Elongation factor 2
EEF2	P13639	299	337	17	362	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EEF2	P13639	571	689	586	587	Site	Note=Cleavage;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24648518;Dbxref=PMID:24648518
EEF2	P13639	571	689	605	606	Site	Note=Cleavage;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24648518;Dbxref=PMID:24648518
EEF2	P13639	299	337	325	325	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05197
EEF2	P13639	571	689	572	572	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58252
EEF2	P13639	571	689	595	595	Modified residue	Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:23184662;Dbxref=PMID:23186163,PMID:23184662
EEF2	P13639	571	689	619	619	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58252
EEF2	P13639	689	750	715	715	Modified residue	Note=Diphthamide;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF2	P13639	299	337	322	322	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24648518;Dbxref=PMID:24648518
EEF2	P13639	571	689	596	596	Natural variant	ID=VAR_070792;Note=In SCA26%3B compromises the mechanics of translocation. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001565;Dbxref=dbSNP:rs587777052,PMID:23001565
EEF2	P13639	571	689	595	595	Mutagenesis	Note=Strongly reduced phosphorylation at Thr-57. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23184662;Dbxref=PMID:23184662
EEF2	P13639	571	689	599	599	Mutagenesis	Note=Strongly reduced phosphorylation at Thr-57. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23184662;Dbxref=PMID:23184662
EFHD1	Q9BUP0	150	195	1	239	Chain	ID=PRO_0000073643;Note=EF-hand domain-containing protein D1
EFHD1	Q9BUP0	150	195	126	161	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EFHD1	Q9BUP0	150	195	139	150	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EFHD1	Q9BUP0	150	195	186	186	Natural variant	ID=VAR_047966;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11550699,PMID:14702039,PMID:15489334
EFHD1	Q9BUP0	150	195	150	150	Mutagenesis	Note=In mtEFHD1%3B abolished ability to enhance mitoflash activity%3B when associated with A-103%3B K-114 and A-139. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26975899;Dbxref=PMID:26975899
GRK6	P43250	422	468	1	576	Chain	ID=PRO_0000085974;Note=G protein-coupled receptor kinase 6
GRK6	P43250	422	468	186	448	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GRK6	P43250	422	468	449	514	Domain	Note=AGC-kinase C-terminal
GRK6	P43250	422	468	414	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ACX
GRK6	P43250	422	468	428	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ACX
GRK6	P43250	422	468	435	437	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ACX
GRK6	P43250	422	468	438	443	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ACX
GRK6	P43250	422	468	446	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ACX
GRK6	P43250	422	468	453	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ACX
GRM4	Q14833	342	389	33	912	Chain	ID=PRO_0000012930;Note=Metabotropic glutamate receptor 4
GRM4	Q14833	342	389	33	587	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRM4	Q14833	342	389	249	538	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRM4	Q14833	342	389	372	388	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRM4	Q14833	342	389	343	390	Alternative sequence	ID=VSP_046763;Note=In isoform 5. GFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DONSON	Q9NYP3	450	521	1	566	Chain	ID=PRO_0000079979;Note=Protein downstream neighbor of Son
DONSON	Q9NYP3	450	521	264	566	Alternative sequence	ID=VSP_004193;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10773462;Dbxref=PMID:10773462
DONSON	Q9NYP3	450	521	266	566	Alternative sequence	ID=VSP_004195;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10773462;Dbxref=PMID:10773462
DONSON	Q9NYP3	450	521	293	566	Natural variant	ID=VAR_079334;Note=In MISSLA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191891;Dbxref=PMID:28191891
DONSON	Q9NYP3	450	521	419	566	Natural variant	ID=VAR_079336;Note=In MISSLA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191891;Dbxref=PMID:28191891
DONSON	Q9NYP3	450	521	428	566	Natural variant	ID=VAR_079337;Note=In MISSLA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191891;Dbxref=PMID:28191891
DONSON	Q9NYP3	450	521	489	489	Natural variant	ID=VAR_079340;Note=In MISSLA%3B unknown pathological significance%3B reduced protein level%3B no effect on nuclear localization%3B does not complement loss of endogenous DONSON when tested for the rescue of the spontaneous fork stalling observed after DONSON depletion. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191891;Dbxref=dbSNP:rs146664036,PMID:28191891
DONSON	Q9NYP3	450	521	504	504	Natural variant	ID=VAR_079341;Note=In MISSLA. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191891;Dbxref=dbSNP:rs374688527,PMID:28191891
GPC2	Q8N158	341	390	24	554	Chain	ID=PRO_0000012303;Note=Glypican-2
DPP3	Q9NY33	90	120	2	737	Chain	ID=PRO_0000078238;Note=Dipeptidyl peptidase 3
DPP3	Q9NY33	432	463	2	737	Chain	ID=PRO_0000078238;Note=Dipeptidyl peptidase 3
DPP3	Q9NY33	566	626	2	737	Chain	ID=PRO_0000078238;Note=Dipeptidyl peptidase 3
DPP3	Q9NY33	432	463	451	451	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55096
DPP3	Q9NY33	432	463	450	450	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3FVY,ECO:0000269|PubMed:22493238;Dbxref=PMID:22493238
DPP3	Q9NY33	432	463	455	455	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3FVY,ECO:0000269|PubMed:22493238;Dbxref=PMID:22493238
DPP3	Q9NY33	90	120	91	120	Alternative sequence	ID=VSP_044696;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPP3	Q9NY33	432	463	182	601	Alternative sequence	ID=VSP_005510;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPP3	Q9NY33	566	626	182	601	Alternative sequence	ID=VSP_005510;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPP3	Q9NY33	90	120	86	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	90	120	104	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	90	120	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	90	120	120	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	432	463	429	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	432	463	453	456	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	566	626	567	581	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	566	626	586	593	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	566	626	597	605	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	566	626	607	609	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	566	626	610	613	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DPP3	Q9NY33	566	626	614	630	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E33
DHRS4L2	Q6PKH6	102	136	21	230	Chain	ID=PRO_0000312103;Note=Dehydrogenase/reductase SDR family member 4-like 2
CRMP1	Q14194	180	207	1	572	Chain	ID=PRO_0000165909;Note=Dihydropyrimidinase-related protein 1
CRMP1	Q14194	180	207	178	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B3Z
CRMP1	Q14194	180	207	194	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B3Z
CRMP1	Q14194	180	207	202	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B3Z
DUOX2	Q9NRD8	1465	1508	26	1548	Chain	ID=PRO_0000223349;Note=Dual oxidase 2
DUOX2	Q9NRD8	1413	1465	26	1548	Chain	ID=PRO_0000223349;Note=Dual oxidase 2
DUOX2	Q9NRD8	974	1001	26	1548	Chain	ID=PRO_0000223349;Note=Dual oxidase 2
DUOX2	Q9NRD8	716	778	26	1548	Chain	ID=PRO_0000223349;Note=Dual oxidase 2
DUOX2	Q9NRD8	564	610	26	1548	Chain	ID=PRO_0000223349;Note=Dual oxidase 2
DUOX2	Q9NRD8	564	610	26	601	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX2	Q9NRD8	564	610	602	622	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX2	Q9NRD8	974	1001	623	1041	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX2	Q9NRD8	716	778	623	1041	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX2	Q9NRD8	1465	1508	1266	1548	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX2	Q9NRD8	1413	1465	1266	1548	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX2	Q9NRD8	564	610	30	596	Region	Note=Peroxidase-like%3B mediates peroxidase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
DUOX2	Q9NRD8	974	1001	960	1245	Region	Note=Interaction with TXNDC11;Ontology_term=ECO:0000250;evidence=ECO:0000250
DUOX2	Q9NRD8	974	1001	124	1162	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25761904;Dbxref=PMID:25761904
DUOX2	Q9NRD8	716	778	124	1162	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25761904;Dbxref=PMID:25761904
DUOX2	Q9NRD8	564	610	124	1162	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25761904;Dbxref=PMID:25761904
DUOX2	Q9NRD8	564	610	568	568	Disulfide bond	Note=Interchain (with C-167 in DUOXA2);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25761904;Dbxref=PMID:25761904
DUOX2	Q9NRD8	564	610	582	582	Disulfide bond	Note=Interchain (with C-233 in DUOXA2);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25761904;Dbxref=PMID:25761904
DUOX2	Q9NRD8	1465	1508	1492	1492	Natural variant	ID=VAR_075550;Note=Found in a patient with very early onset inflammatory bowel disease%3B unknown pathological significance%3B no effect on subcellular location%3B significantly reduced ROS generation%2C which may decrease resistance to infection by enteric pathogens%2C such as Escherichia coli. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26301257;Dbxref=dbSNP:rs374410986,PMID:26301257
DUOX2	Q9NRD8	974	1001	984	984	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L4A	Q9HCS5	459	474	1	686	Chain	ID=PRO_0000219401;Note=Band 4.1-like protein 4A
EPB41L4A	Q9HCS5	393	420	1	686	Chain	ID=PRO_0000219401;Note=Band 4.1-like protein 4A
EPB41L4A	Q9HCS5	33	68	1	686	Chain	ID=PRO_0000219401;Note=Band 4.1-like protein 4A
EPB41L4A	Q9HCS5	33	68	11	299	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L4A	Q9HCS5	393	420	393	393	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L4A	Q9HCS5	393	420	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
EPB41L4A	Q9HCS5	393	420	411	413	Sequence conflict	Note=HAP->LMHS;Ontology_term=ECO:0000305;evidence=ECO:0000305
E4F1	Q66K89	352	422	1	784	Chain	ID=PRO_0000324307;Note=Transcription factor E4F1
E4F1	Q66K89	352	422	369	566	Region	Note=Mediates interaction with CDKN2A
E4F1	Q66K89	352	422	355	355	Natural variant	ID=VAR_060271;Note=V->I;Dbxref=dbSNP:rs59784157
E4F1	Q66K89	352	422	363	364	Sequence conflict	Note=SE->RK;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF2AK2	P19525	493	511	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	416	459	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	303	355	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	262	302	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	241	261	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	493	511	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	416	459	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	303	355	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	262	302	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	241	261	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	493	511	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	416	459	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	303	355	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	262	302	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	493	511	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	416	459	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	303	355	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	262	302	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	303	355	331	343	Repeat	Note=1
EIF2AK2	P19525	303	355	331	343	Repeat	Note=1
EIF2AK2	P19525	303	355	345	357	Repeat	Note=2
EIF2AK2	P19525	303	355	345	357	Repeat	Note=2
EIF2AK2	P19525	262	302	273	281	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	262	302	273	281	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	493	511	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	416	459	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	303	355	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	262	302	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	493	511	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	416	459	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	303	355	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	262	302	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	303	355	331	357	Region	Note=2 X 13 AA approximate repeats
EIF2AK2	P19525	303	355	331	357	Region	Note=2 X 13 AA approximate repeats
EIF2AK2	P19525	262	302	296	296	Binding site	Note=ATP
EIF2AK2	P19525	262	302	296	296	Binding site	Note=ATP
EIF2AK2	P19525	241	261	242	242	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	242	242	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	255	255	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	255	255	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	293	293	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
EIF2AK2	P19525	262	302	293	293	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
EIF2AK2	P19525	416	459	446	446	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
EIF2AK2	P19525	416	459	446	446	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
EIF2AK2	P19525	416	459	451	451	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
EIF2AK2	P19525	416	459	451	451	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
EIF2AK2	P19525	416	459	456	456	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
EIF2AK2	P19525	416	459	456	456	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
EIF2AK2	P19525	303	355	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	262	302	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	303	355	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	262	302	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	416	459	428	428	Natural variant	ID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
EIF2AK2	P19525	416	459	428	428	Natural variant	ID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
EIF2AK2	P19525	416	459	439	439	Natural variant	ID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EIF2AK2	P19525	416	459	439	439	Natural variant	ID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EIF2AK2	P19525	493	511	506	506	Natural variant	ID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
EIF2AK2	P19525	493	511	506	506	Natural variant	ID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
EIF2AK2	P19525	241	261	242	242	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	242	242	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	241	261	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	262	302	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	241	261	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	241	261	255	255	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	255	255	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Mutagenesis	Note=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Mutagenesis	Note=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	296	296	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	296	296	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	416	459	446	446	Mutagenesis	Note=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	416	459	446	446	Mutagenesis	Note=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	416	459	451	451	Mutagenesis	Note=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	416	459	451	451	Mutagenesis	Note=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	262	302	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	241	261	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	241	261	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	267	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	267	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	276	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	276	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	292	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	292	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	306	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	306	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	323	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	323	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	427	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	427	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	457	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	457	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	488	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	488	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	505	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
EIF2AK2	P19525	493	511	505	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
EIF2AK2	P19525	493	511	509	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	509	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
DYNAP	Q8N1N2	45	100	1	210	Chain	ID=PRO_0000079315;Note=Dynactin-associated protein
DYNAP	Q8N1N2	45	100	1	113	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EAF2	Q96CJ1	161	245	1	260	Chain	ID=PRO_0000130337;Note=ELL-associated factor 2
EAF2	Q96CJ1	161	245	177	260	Region	Note=Necessary for transactivation activity
EAF2	Q96CJ1	161	245	174	207	Compositional bias	Note=Ser-rich
HADHB	P55084	21	36	1	33	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:12665801;Dbxref=PMID:25944712,PMID:12665801
HADHB	P55084	21	36	34	474	Chain	ID=PRO_0000034080;Note=Trifunctional enzyme subunit beta%2C mitochondrial
HADHB	P55084	70	84	34	474	Chain	ID=PRO_0000034080;Note=Trifunctional enzyme subunit beta%2C mitochondrial
HADHB	P55084	408	463	34	474	Chain	ID=PRO_0000034080;Note=Trifunctional enzyme subunit beta%2C mitochondrial
HADHB	P55084	408	463	428	428	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10020
HADHB	P55084	408	463	458	458	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10020
HADHB	P55084	70	84	72	72	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HADHB	P55084	70	84	72	72	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JY0
HADHB	P55084	21	36	1	36	Alternative sequence	ID=VSP_054426;Note=In isoform 2. MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAP->MTLVSGWLLYGWII;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HADHB	P55084	408	463	444	444	Natural variant	ID=VAR_017409;Note=In MTPD. R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754706,ECO:0000269|PubMed:9259266;Dbxref=dbSNP:rs121913134,PMID:12754706,PMID:9259266
ECM2	O94769	160	351	21	699	Chain	ID=PRO_0000032731;Note=Extracellular matrix protein 2
ECM2	O94769	160	351	307	344	Domain	Note=LRRNT
ECM2	O94769	160	351	294	296	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
ECM2	O94769	160	351	270	281	Compositional bias	Note=Poly-Glu
ECM2	O94769	160	351	161	182	Alternative sequence	ID=VSP_039114;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ECM2	O94769	160	351	204	204	Natural variant	ID=VAR_052011;Note=R->Q;Dbxref=dbSNP:rs34758505
EDC4	Q6P2E9	263	298	2	1401	Chain	ID=PRO_0000278962;Note=Enhancer of mRNA-decapping protein 4
EDC4	Q6P2E9	263	298	217	269	Repeat	Note=WD 3
EDC4	Q6P2E9	263	298	287	326	Repeat	Note=WD 4
EDC4	Q6P2E9	263	298	1	381	Alternative sequence	ID=VSP_023412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EDC4	Q6P2E9	263	298	271	272	Sequence conflict	Note=ML->IV;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFHC2	Q5JST6	650	680	1	749	Chain	ID=PRO_0000251703;Note=EF-hand domain-containing family member C2
EFNA1	P20827	129	151	19	182	Chain	ID=PRO_0000008353;Note=Ephrin-A1
EFNA1	P20827	129	151	19	151	Domain	Note=Ephrin RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00884
EFNA1	P20827	129	151	80	140	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3HEI,ECO:0000269|PubMed:19525919,ECO:0000269|PubMed:20505120;Dbxref=PMID:19525919,PMID:20505120
EFNA1	P20827	129	151	131	152	Alternative sequence	ID=VSP_017543;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFNA1	P20827	129	151	125	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HEI
EFNA1	P20827	129	151	142	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HEI
ENTPD4	Q9Y227	222	242	1	616	Chain	ID=PRO_0000209911;Note=Ectonucleoside triphosphate diphosphohydrolase 4
ENTPD4	Q9Y227	222	242	55	559	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD4	Q9Y227	222	242	222	222	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD5	O75356	295	342	25	428	Chain	ID=PRO_0000019908;Note=Ectonucleoside triphosphate diphosphohydrolase 5
ENTPD5	O75356	261	295	25	428	Chain	ID=PRO_0000019908;Note=Ectonucleoside triphosphate diphosphohydrolase 5
ENTPD5	O75356	99	147	25	428	Chain	ID=PRO_0000019908;Note=Ectonucleoside triphosphate diphosphohydrolase 5
ENTPD5	O75356	295	342	272	303	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD5	O75356	261	295	272	303	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ENTPD5	O75356	295	342	314	314	Natural variant	ID=VAR_050308;Note=K->R;Dbxref=dbSNP:rs17094434
COLGALT2	Q8IYK4	277	317	28	626	Chain	ID=PRO_0000309541;Note=Procollagen galactosyltransferase 2
COLGALT2	Q8IYK4	164	209	28	626	Chain	ID=PRO_0000309541;Note=Procollagen galactosyltransferase 2
COLGALT2	Q8IYK4	164	209	185	185	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPCAM	P16422	142	163	24	314	Chain	ID=PRO_0000022467;Note=Epithelial cell adhesion molecule
EPCAM	P16422	185	219	24	314	Chain	ID=PRO_0000022467;Note=Epithelial cell adhesion molecule
EPCAM	P16422	286	301	24	314	Chain	ID=PRO_0000022467;Note=Epithelial cell adhesion molecule
EPCAM	P16422	142	163	24	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPCAM	P16422	185	219	24	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPCAM	P16422	286	301	266	288	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPCAM	P16422	286	301	289	314	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPCAM	P16422	185	219	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18508581,ECO:0000269|PubMed:19159218;Dbxref=PMID:18508581,PMID:19159218
EPCAM	P16422	185	219	198	198	Mutagenesis	Note=Decreased glycosyation%2C reduced protein stability and significant decrease in protein expression. Complete loss of glycosylation and substantial decrease in protein expression%3B when associated with A-74 and A-111. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18508581;Dbxref=PMID:18508581
EPCAM	P16422	142	163	141	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZV
EPCAM	P16422	142	163	159	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZV
EPCAM	P16422	185	219	181	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZV
EPCAM	P16422	185	219	190	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZV
EPCAM	P16422	185	219	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZV
EPCAM	P16422	185	219	209	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZV
EPAS1	Q99814	762	820	1	870	Chain	ID=PRO_0000127419;Note=Endothelial PAS domain-containing protein 1
EPAS1	Q99814	762	820	766	766	Natural variant	ID=VAR_061261;Note=T->P;Dbxref=dbSNP:rs59901247
EPAS1	Q99814	762	820	785	785	Natural variant	ID=VAR_061262;Note=P->T;Dbxref=dbSNP:rs61518065
EPAS1	Q99814	762	820	765	765	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPAS1	Q99814	762	820	769	769	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHA2	P29317	775	825	24	976	Chain	ID=PRO_0000016800;Note=Ephrin type-A receptor 2
EPHA2	P29317	775	825	559	976	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA2	P29317	775	825	613	875	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA2	P29317	775	825	606	906	Region	Note=Mediates interaction with ARHGEF16 and ELMO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20679435;Dbxref=PMID:20679435
EPHA2	P29317	775	825	498	976	Alternative sequence	ID=VSP_056015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHA2	P29317	775	825	777	777	Natural variant	ID=VAR_042124;Note=In a gastric adenocarcinoma sample%3B somatic mutation. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs922655349,PMID:17344846
EPHA2	P29317	775	825	776	778	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKH
EPHA2	P29317	775	825	781	783	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKF
EPHA2	P29317	775	825	786	791	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKF
EPHA2	P29317	775	825	796	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKF
EPHA2	P29317	775	825	817	820	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKF
EPHA2	P29317	775	825	823	831	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKF
EPC2	Q52LR7	153	222	1	807	Chain	ID=PRO_0000239295;Note=Enhancer of polycomb homolog 2
EPC2	Q52LR7	316	380	1	807	Chain	ID=PRO_0000239295;Note=Enhancer of polycomb homolog 2
EPC2	Q52LR7	153	222	195	195	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EPC2	Q52LR7	316	380	324	324	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
EPC2	Q52LR7	316	380	362	362	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ERAL1	O75616	137	163	44	437	Chain	ID=PRO_0000180081;Note=GTPase Era%2C mitochondrial
ERAL1	O75616	237	320	44	437	Chain	ID=PRO_0000180081;Note=GTPase Era%2C mitochondrial
ERAL1	O75616	137	163	112	330	Domain	Note=Era-type G
ERAL1	O75616	237	320	112	330	Domain	Note=Era-type G
ERAL1	O75616	237	320	236	239	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAL1	O75616	237	320	257	437	Alternative sequence	ID=VSP_001453;Note=In isoform HERA-B. GVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHLPQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLMDIFLCDVDIRLSVKLLK->AIPSDTGPARALGVPQCSPH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10945472;Dbxref=PMID:10945472
ERAP2	Q6P179	238	283	1	960	Chain	ID=PRO_0000315719;Note=Endoplasmic reticulum aminopeptidase 2
ERAP2	Q6P179	413	457	1	960	Chain	ID=PRO_0000315719;Note=Endoplasmic reticulum aminopeptidase 2
ERAP2	Q6P179	457	501	1	960	Chain	ID=PRO_0000315719;Note=Endoplasmic reticulum aminopeptidase 2
ERAP2	Q6P179	501	524	1	960	Chain	ID=PRO_0000315719;Note=Endoplasmic reticulum aminopeptidase 2
ERAP2	Q6P179	238	283	41	960	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAP2	Q6P179	413	457	41	960	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAP2	Q6P179	457	501	41	960	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAP2	Q6P179	501	524	41	960	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERAP2	Q6P179	413	457	455	455	Site	Note=Transition state stabilizer
ERAP2	Q6P179	413	457	421	460	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22106953;Dbxref=PMID:22106953
ERAP2	Q6P179	457	501	421	460	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22106953;Dbxref=PMID:22106953
ERAP2	Q6P179	238	283	238	282	Alternative sequence	ID=VSP_030671;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERAP2	Q6P179	413	457	351	960	Alternative sequence	ID=VSP_030673;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERAP2	Q6P179	457	501	351	960	Alternative sequence	ID=VSP_030673;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERAP2	Q6P179	501	524	351	960	Alternative sequence	ID=VSP_030673;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERAP2	Q6P179	238	283	238	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	238	283	245	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J6S
ERAP2	Q6P179	238	283	249	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	238	283	261	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	238	283	266	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	238	283	272	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	238	283	283	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	413	457	413	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	413	457	418	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	413	457	430	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J6S
ERAP2	Q6P179	413	457	443	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	413	457	452	455	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	413	457	456	469	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	457	501	456	469	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	457	501	471	485	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	457	501	488	490	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	457	501	492	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	501	524	504	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	501	524	510	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
ERAP2	Q6P179	501	524	522	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AB0
CLINT1	Q14677	337	362	1	625	Chain	ID=PRO_0000074521;Note=Clathrin interactor 1
CLINT1	Q14677	337	362	311	485	Compositional bias	Note=Ser-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00016
CLINT1	Q14677	337	362	349	349	Mutagenesis	Note=Decreases AP-1 and AP-2 binding. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12538641;Dbxref=PMID:12538641
ERBB3	P21860	182	204	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	291	329	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	685	725	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	725	758	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	758	820	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	897	946	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	979	1043	20	1342	Chain	ID=PRO_0000016672;Note=Receptor tyrosine-protein kinase erbB-3
ERBB3	P21860	182	204	20	643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	291	329	20	643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	685	725	665	1342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	725	758	665	1342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	758	820	665	1342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	897	946	665	1342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	979	1043	665	1342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB3	P21860	685	725	709	966	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB3	P21860	725	758	709	966	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB3	P21860	758	820	709	966	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB3	P21860	897	946	709	966	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB3	P21860	685	725	715	723	Nucleotide binding	Note=ATP
ERBB3	P21860	758	820	788	790	Nucleotide binding	Note=ATP
ERBB3	P21860	725	758	742	742	Binding site	Note=ATP
ERBB3	P21860	685	725	686	686	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ERBB3	P21860	979	1043	982	982	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ERBB3	P21860	182	204	156	183	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154198;Dbxref=PMID:12154198
ERBB3	P21860	182	204	186	194	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154198;Dbxref=PMID:12154198
ERBB3	P21860	182	204	190	202	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154198;Dbxref=PMID:12154198
ERBB3	P21860	291	329	290	301	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154198;Dbxref=PMID:12154198
ERBB3	P21860	291	329	305	320	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154198;Dbxref=PMID:12154198
ERBB3	P21860	291	329	323	327	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154198;Dbxref=PMID:12154198
ERBB3	P21860	182	204	1	643	Alternative sequence	ID=VSP_041661;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERBB3	P21860	291	329	1	643	Alternative sequence	ID=VSP_041661;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERBB3	P21860	182	204	141	183	Alternative sequence	ID=VSP_002893;Note=In isoform 2. EILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSC->GQFPMVPSGLTPQPAQDWYLLDDDPRLLTLSASSKVPVTLAAV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	182	204	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	291	329	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	685	725	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	725	758	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	758	820	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	897	946	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	979	1043	184	1342	Alternative sequence	ID=VSP_002894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685162;Dbxref=PMID:7685162
ERBB3	P21860	685	725	332	1342	Alternative sequence	ID=VSP_041664;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ERBB3	P21860	725	758	332	1342	Alternative sequence	ID=VSP_041664;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ERBB3	P21860	758	820	332	1342	Alternative sequence	ID=VSP_041664;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ERBB3	P21860	897	946	332	1342	Alternative sequence	ID=VSP_041664;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ERBB3	P21860	979	1043	332	1342	Alternative sequence	ID=VSP_041664;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ERBB3	P21860	182	204	204	204	Natural variant	ID=VAR_042104;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56107455,PMID:17344846
ERBB3	P21860	685	725	717	717	Natural variant	ID=VAR_042106;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35961836,PMID:17344846
ERBB3	P21860	725	758	744	744	Natural variant	ID=VAR_042107;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55787439,PMID:17344846
ERBB3	P21860	979	1043	998	998	Natural variant	ID=VAR_042108;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56259600,PMID:17344846
ERBB3	P21860	725	758	742	742	Mutagenesis	Note=Strongly reduced autophosphorylation. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20351256;Dbxref=PMID:20351256
ERBB3	P21860	182	204	188	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LEO
ERBB3	P21860	182	204	194	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6B
ERBB3	P21860	291	329	295	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6B
ERBB3	P21860	291	329	300	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6B
ERBB3	P21860	291	329	309	314	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6B
ERBB3	P21860	291	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6B
ERBB3	P21860	291	329	324	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LEO
ERBB3	P21860	685	725	706	708	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	685	725	709	716	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	685	725	722	728	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	725	758	722	728	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	725	758	731	733	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LMG
ERBB3	P21860	725	758	737	744	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	725	758	747	749	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	725	758	753	755	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RIY
ERBB3	P21860	725	758	758	764	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	758	820	758	764	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	758	820	774	778	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	758	820	780	788	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	758	820	795	802	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	758	820	803	805	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	758	820	808	827	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	897	946	890	905	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	897	946	911	914	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	897	946	917	919	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	897	946	920	925	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	897	946	938	947	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTW
ERBB3	P21860	979	1043	980	983	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KEX
ERBB4	Q15303	1045	1061	26	1308	Chain	ID=PRO_0000016674;Note=Receptor tyrosine-protein kinase erbB-4
ERBB4	Q15303	624	648	26	1308	Chain	ID=PRO_0000016674;Note=Receptor tyrosine-protein kinase erbB-4
ERBB4	Q15303	1045	1061	676	1308	Chain	ID=PRO_0000396797;Note=ERBB4 intracellular domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
ERBB4	Q15303	624	648	26	651	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB4	Q15303	1045	1061	676	1308	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB4	Q15303	1045	1061	1053	1056	Motif	Note=PPxY motif 2
ERBB4	Q15303	624	648	496	633	Compositional bias	Note=Cys-rich
ERBB4	Q15303	1045	1061	1056	1056	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17120616,ECO:0000269|PubMed:18721752,ECO:0000269|PubMed:8617750;Dbxref=PMID:17120616,PMID:18721752,PMID:8617750
ERBB4	Q15303	624	648	617	625	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16203964;Dbxref=PMID:16203964
ERBB4	Q15303	624	648	621	633	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16203964;Dbxref=PMID:16203964
ERBB4	Q15303	624	648	626	648	Alternative sequence	ID=VSP_002895;Note=In isoform JM-B CYT-1 and isoform JM-B CYT-2. NGPTSHDCIYYPWTGHSTLPQHA->IGSSIEDCIGLMD;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9334263;Dbxref=PMID:15489334,PMID:9334263
ERBB4	Q15303	1045	1061	1046	1061	Alternative sequence	ID=VSP_022148;Note=In isoform JM-A CYT-2 and isoform JM-B CYT-2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ERBB4	Q15303	624	648	646	646	Mutagenesis	Note=Constitutively activated kinase. Q->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17120616;Dbxref=PMID:17120616
ERBB4	Q15303	1045	1061	1056	1056	Mutagenesis	Note=Abolishes interaction with NEDD4 and impairs ubiquitination. Promotes nuclear translocation of ERBB4 intracellular domain E4ICD1. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561640;Dbxref=PMID:19561640
ERBB4	Q15303	1045	1061	1056	1056	Mutagenesis	Note=Abolishes interaction with WWP1%3B when associated with F-1301. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561640;Dbxref=PMID:19561640
ERBB4	Q15303	624	648	625	629	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AHX
ERCC6	Q03468	762	794	1	1493	Chain	ID=PRO_0000074314;Note=DNA excision repair protein ERCC-6
ERCC6	Q03468	509	561	1	1493	Chain	ID=PRO_0000074314;Note=DNA excision repair protein ERCC-6
ERCC6	Q03468	509	561	519	695	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ERCC6	Q03468	509	561	532	539	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
GSPT1	P15170	396	426	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	338	396	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	311	338	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	95	120	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	7	83	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	396	426	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	338	396	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	311	338	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	95	120	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	7	83	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	95	120	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	95	120	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	81	88	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GSPT1	P15170	7	83	81	88	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GSPT1	P15170	7	83	81	88	Region	Note=G1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	81	88	Region	Note=G1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	8	8	Alternative sequence	ID=VSP_042199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSPT1	P15170	7	83	8	8	Alternative sequence	ID=VSP_042199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERLEC1	Q96DZ1	89	116	34	483	Chain	ID=PRO_0000042182;Note=Endoplasmic reticulum lectin 1
ERLEC1	Q96DZ1	293	347	34	483	Chain	ID=PRO_0000042182;Note=Endoplasmic reticulum lectin 1
ERLEC1	Q96DZ1	347	367	34	483	Chain	ID=PRO_0000042182;Note=Endoplasmic reticulum lectin 1
ERLEC1	Q96DZ1	409	434	34	483	Chain	ID=PRO_0000042182;Note=Endoplasmic reticulum lectin 1
ERLEC1	Q96DZ1	89	116	111	180	Domain	Note=PRKCSH 1
ERLEC1	Q96DZ1	293	347	342	418	Domain	Note=PRKCSH 2
ERLEC1	Q96DZ1	347	367	342	418	Domain	Note=PRKCSH 2
ERLEC1	Q96DZ1	409	434	342	418	Domain	Note=PRKCSH 2
ERLEC1	Q96DZ1	293	347	294	347	Alternative sequence	ID=VSP_015790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ERLEC1	Q96DZ1	347	367	294	347	Alternative sequence	ID=VSP_015790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ERLEC1	Q96DZ1	409	434	410	435	Alternative sequence	ID=VSP_047155;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERLEC1	Q96DZ1	293	347	318	318	Natural variant	ID=VAR_051493;Note=V->L;Dbxref=dbSNP:rs2287345
ERLEC1	Q96DZ1	409	434	428	428	Mutagenesis	Note=Abolishes interaction with SEL1L. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18264092;Dbxref=PMID:18264092
ERLEC1	Q96DZ1	293	347	331	331	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERG	P11308	204	231	1	486	Chain	ID=PRO_0000204103;Note=Transcriptional regulator ERG
ERG	P11308	204	231	1	486	Chain	ID=PRO_0000204103;Note=Transcriptional regulator ERG
ERG	P11308	204	231	120	206	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ERG	P11308	204	231	120	206	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ERI1	Q8IV48	166	194	2	349	Chain	ID=PRO_0000187007;Note=3'-5' exoribonuclease 1
ERI1	Q8IV48	166	194	2	349	Chain	ID=PRO_0000187007;Note=3'-5' exoribonuclease 1
ERI1	Q8IV48	166	194	2	349	Chain	ID=PRO_0000187007;Note=3'-5' exoribonuclease 1
ERI1	Q8IV48	166	194	130	306	Domain	Note=Exonuclease
ERI1	Q8IV48	166	194	130	306	Domain	Note=Exonuclease
ERI1	Q8IV48	166	194	130	306	Domain	Note=Exonuclease
ERI1	Q8IV48	166	194	165	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	165	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	165	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	184	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	184	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	184	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	194	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	194	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI1	Q8IV48	166	194	194	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W0H
ERI2	A8K979	30	58	1	691	Chain	ID=PRO_0000338973;Note=ERI1 exoribonuclease 2
ERI2	A8K979	30	58	37	226	Domain	Note=Exonuclease
ERI2	A8K979	30	58	43	43	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERI2	A8K979	30	58	41	41	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
ERI2	A8K979	30	58	41	41	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
ERI2	A8K979	30	58	43	43	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
ERI2	A8K979	30	58	43	43	Binding site	Note=AMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ERI2	A8K979	30	58	1	93	Alternative sequence	ID=VSP_034077;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERN1	O75460	159	193	19	977	Chain	ID=PRO_0000024327;Note=Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1	O75460	159	193	19	443	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERN1	O75460	159	193	176	176	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERN1	O75460	159	193	71	977	Alternative sequence	ID=VSP_034583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ERN1	O75460	159	193	190	191	Sequence conflict	Note=DV->EG;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN1	O75460	159	193	154	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ6
ERN1	O75460	159	193	168	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ6
ERN1	O75460	159	193	176	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ6
ESCO2	Q56NI9	451	499	1	601	Chain	ID=PRO_0000074542;Note=N-acetyltransferase ESCO2
ETV5	P41161	403	437	1	510	Chain	ID=PRO_0000204118;Note=ETS translocation variant 5
ETV5	P41161	403	437	1	510	Chain	ID=PRO_0000204118;Note=ETS translocation variant 5
ETV5	P41161	403	437	368	448	DNA binding	Note=ETS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00237
ETV5	P41161	403	437	368	448	DNA binding	Note=ETS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00237
ETV5	P41161	403	437	401	412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ILV
ETV5	P41161	403	437	401	412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ILV
ETV5	P41161	403	437	419	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ILV
ETV5	P41161	403	437	419	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ILV
ETV5	P41161	403	437	434	437	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ILV
ETV5	P41161	403	437	434	437	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ILV
FBXL19	Q6PCT2	156	229	1	694	Chain	ID=PRO_0000119868;Note=F-box/LRR-repeat protein 19
FBXL19	Q6PCT2	229	283	1	694	Chain	ID=PRO_0000119868;Note=F-box/LRR-repeat protein 19
FBXL19	Q6PCT2	156	229	186	302	Compositional bias	Note=Pro-rich
FBXL19	Q6PCT2	229	283	186	302	Compositional bias	Note=Pro-rich
FBXL19	Q6PCT2	229	283	241	283	Alternative sequence	ID=VSP_013015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIKFYVE	Q9Y2I7	489	545	2	2098	Chain	ID=PRO_0000185452;Note=1-phosphatidylinositol 3-phosphate 5-kinase
PIKFYVE	Q9Y2I7	694	730	2	2098	Chain	ID=PRO_0000185452;Note=1-phosphatidylinositol 3-phosphate 5-kinase
PIKFYVE	Q9Y2I7	1240	1263	2	2098	Chain	ID=PRO_0000185452;Note=1-phosphatidylinositol 3-phosphate 5-kinase
PIKFYVE	Q9Y2I7	1644	1675	2	2098	Chain	ID=PRO_0000185452;Note=1-phosphatidylinositol 3-phosphate 5-kinase
PIKFYVE	Q9Y2I7	1676	1703	2	2098	Chain	ID=PRO_0000185452;Note=1-phosphatidylinositol 3-phosphate 5-kinase
PIKFYVE	Q9Y2I7	1736	1791	2	2098	Chain	ID=PRO_0000185452;Note=1-phosphatidylinositol 3-phosphate 5-kinase
PIKFYVE	Q9Y2I7	1736	1791	1758	2084	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIKFYVE	Q9Y2I7	1736	1791	1754	1754	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PIKFYVE	Q9Y2I7	694	730	549	2098	Alternative sequence	ID=VSP_040111;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIKFYVE	Q9Y2I7	1240	1263	549	2098	Alternative sequence	ID=VSP_040111;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIKFYVE	Q9Y2I7	1644	1675	549	2098	Alternative sequence	ID=VSP_040111;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIKFYVE	Q9Y2I7	1676	1703	549	2098	Alternative sequence	ID=VSP_040111;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIKFYVE	Q9Y2I7	1736	1791	549	2098	Alternative sequence	ID=VSP_040111;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIKFYVE	Q9Y2I7	694	730	696	696	Natural variant	ID=VAR_063406;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|Ref.1,ECO:0000269|Ref.3;Dbxref=dbSNP:rs10932258
FUZ	Q9BT04	230	262	1	418	Chain	ID=PRO_0000312920;Note=Protein fuzzy homolog
FUZ	Q9BT04	164	230	1	418	Chain	ID=PRO_0000312920;Note=Protein fuzzy homolog
FUZ	Q9BT04	230	262	235	418	Compositional bias	Note=Leu-rich
FUZ	Q9BT04	164	230	175	175	Natural variant	ID=VAR_037616;Note=G->D;Dbxref=dbSNP:rs35002951
GPR137B	O60478	229	279	1	399	Chain	ID=PRO_0000072583;Note=Integral membrane protein GPR137B
GPR137B	O60478	279	322	1	399	Chain	ID=PRO_0000072583;Note=Integral membrane protein GPR137B
GPR137B	O60478	229	279	210	237	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	229	279	238	258	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	229	279	259	292	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	279	322	259	292	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	279	322	293	313	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	279	322	314	399	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	229	279	263	263	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137B	O60478	229	279	275	275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
G6PD	P11413	485	515	2	515	Chain	ID=PRO_0000068083;Note=Glucose-6-phosphate 1-dehydrogenase
G6PD	P11413	245	286	2	515	Chain	ID=PRO_0000068083;Note=Glucose-6-phosphate 1-dehydrogenase
G6PD	P11413	192	244	2	515	Chain	ID=PRO_0000068083;Note=Glucose-6-phosphate 1-dehydrogenase
G6PD	P11413	455	485	2	515	Chain	ID=PRO_0000068083;Note=Glucose-6-phosphate 1-dehydrogenase
G6PD	P11413	215	256	2	515	Chain	ID=PRO_0000068083;Note=Glucose-6-phosphate 1-dehydrogenase
G6PD	P11413	162	214	2	515	Chain	ID=PRO_0000068083;Note=Glucose-6-phosphate 1-dehydrogenase
G6PD	P11413	192	244	201	205	Region	Note=Substrate binding
G6PD	P11413	162	214	201	205	Region	Note=Substrate binding
G6PD	P11413	245	286	263	263	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
G6PD	P11413	162	214	171	171	Binding site	Note=NADP 1%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10745013,ECO:0000269|PubMed:15858258;Dbxref=PMID:10745013,PMID:15858258
G6PD	P11413	162	214	171	171	Binding site	Note=Substrate
G6PD	P11413	192	244	239	239	Binding site	Note=Substrate
G6PD	P11413	215	256	239	239	Binding site	Note=Substrate
G6PD	P11413	245	286	258	258	Binding site	Note=Substrate
G6PD	P11413	485	515	487	487	Binding site	Note=NADP 2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10745013,ECO:0000269|PubMed:15858258;Dbxref=PMID:10745013,PMID:15858258
G6PD	P11413	485	515	503	503	Binding site	Note=NADP 2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10745013,ECO:0000269|PubMed:15858258;Dbxref=PMID:10745013,PMID:15858258
G6PD	P11413	485	515	509	509	Binding site	Note=NADP 2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10745013,ECO:0000269|PubMed:15858258;Dbxref=PMID:10745013,PMID:15858258
G6PD	P11413	162	214	171	171	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
G6PD	P11413	485	515	497	497	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
G6PD	P11413	485	515	503	503	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
G6PD	P11413	245	286	257	257	Alternative sequence	ID=VSP_001592;Note=In isoform Long. R->RGPGRQGGSGSESCSLSLGSLVWGPHALEPGEQGGELRRALASSVPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
G6PD	P11413	162	214	163	163	Natural variant	ID=VAR_002467;Note=In NSHA%3B Plymouth%3B class I. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7858267;Dbxref=PMID:7858267
G6PD	P11413	162	214	163	163	Natural variant	ID=VAR_002466;Note=In NSHA%3B Mahidol%3B class III%3B associated with reduced density of Plasmodium vivax but not Plasmodium falciparum in Southeast Asians%3B reduced activity. G->S;Dbxref=dbSNP:rs137852314
G6PD	P11413	162	214	165	165	Natural variant	ID=VAR_002468;Note=In NSHA%3B Chinese-3%3B class II. N->D;Dbxref=dbSNP:rs137852331
G6PD	P11413	162	214	166	166	Natural variant	ID=VAR_002469;Note=In NSHA%3B Naone%3B 1%25 activity. R->H
G6PD	P11413	162	214	176	176	Natural variant	ID=VAR_002470;Note=In NSHA%3B Shinshu%3B class I. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8193373;Dbxref=PMID:8193373
G6PD	P11413	162	214	181	181	Natural variant	ID=VAR_002471;Note=In NSHA%3B Santa Maria%3B class I. D->V;Dbxref=dbSNP:rs5030872
G6PD	P11413	162	214	182	182	Natural variant	ID=VAR_002472;Note=In NSHA%3B Vancouver%3B class I. R->W;Dbxref=dbSNP:rs267606836
G6PD	P11413	162	214	188	188	Natural variant	ID=VAR_002473;Note=In NSHA%3B Sassari/Cagliari%3B class II%3B frequent in the Mediterranean. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2912069;Dbxref=dbSNP:rs5030868,PMID:2912069
G6PD	P11413	192	244	198	198	Natural variant	ID=VAR_002474;Note=In NSHA%3B Coimbra%3B class II. R->C;Dbxref=dbSNP:rs137852330
G6PD	P11413	162	214	198	198	Natural variant	ID=VAR_002474;Note=In NSHA%3B Coimbra%3B class II. R->C;Dbxref=dbSNP:rs137852330
G6PD	P11413	192	244	198	198	Natural variant	ID=VAR_002475;Note=In NSHA%3B Santiago%3B class I. R->P;Dbxref=dbSNP:rs137852332
G6PD	P11413	162	214	198	198	Natural variant	ID=VAR_002475;Note=In NSHA%3B Santiago%3B class I. R->P;Dbxref=dbSNP:rs137852332
G6PD	P11413	192	244	198	198	Natural variant	ID=VAR_075555;Note=In NSHA%3B Herlev%3B no glucoshosphate dehydrogenase activity. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26479991;Dbxref=PMID:26479991
G6PD	P11413	162	214	198	198	Natural variant	ID=VAR_075555;Note=In NSHA%3B Herlev%3B no glucoshosphate dehydrogenase activity. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26479991;Dbxref=PMID:26479991
G6PD	P11413	192	244	212	212	Natural variant	ID=VAR_002476;Note=In NSHA%3B Sibari%3B class III. M->V;Dbxref=dbSNP:rs782754619
G6PD	P11413	162	214	212	212	Natural variant	ID=VAR_002476;Note=In NSHA%3B Sibari%3B class III. M->V;Dbxref=dbSNP:rs782754619
G6PD	P11413	192	244	213	213	Natural variant	ID=VAR_002477;Note=In NSHA%3B Minnesota%3B class I. V->L;Dbxref=dbSNP:rs137852326
G6PD	P11413	162	214	213	213	Natural variant	ID=VAR_002477;Note=In NSHA%3B Minnesota%3B class I. V->L;Dbxref=dbSNP:rs137852326
G6PD	P11413	192	244	216	216	Natural variant	ID=VAR_002478;Note=In NSHA%3B Harilaou%3B class I. F->L;Dbxref=dbSNP:rs137852319
G6PD	P11413	215	256	216	216	Natural variant	ID=VAR_002478;Note=In NSHA%3B Harilaou%3B class I. F->L;Dbxref=dbSNP:rs137852319
G6PD	P11413	192	244	227	227	Natural variant	ID=VAR_002480;Note=In NSHA%3B A- type 2%3B class III. R->L;Dbxref=dbSNP:rs137852328
G6PD	P11413	215	256	227	227	Natural variant	ID=VAR_002480;Note=In NSHA%3B A- type 2%3B class III. R->L;Dbxref=dbSNP:rs137852328
G6PD	P11413	192	244	227	227	Natural variant	ID=VAR_002479;Note=In NSHA%3B Mexico City%3B class III. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1611091;Dbxref=dbSNP:rs137852328,PMID:1611091
G6PD	P11413	215	256	227	227	Natural variant	ID=VAR_002479;Note=In NSHA%3B Mexico City%3B class III. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1611091;Dbxref=dbSNP:rs137852328,PMID:1611091
G6PD	P11413	192	244	242	243	Natural variant	ID=VAR_002481;Note=In NSHA%3B Stonybrook%3B class I. Missing
G6PD	P11413	215	256	242	243	Natural variant	ID=VAR_002481;Note=In NSHA%3B Stonybrook%3B class I. Missing
G6PD	P11413	245	286	257	257	Natural variant	ID=VAR_002482;Note=In NSHA%3B Wayne%3B class I. R->G
G6PD	P11413	245	286	274	274	Natural variant	ID=VAR_002483;Note=In NSHA%3B Corum%3B class I. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7858267;Dbxref=PMID:7858267
G6PD	P11413	245	286	278	278	Natural variant	ID=VAR_002484;Note=In NSHA%3B Wexham%3B class I. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7858267;Dbxref=PMID:7858267
G6PD	P11413	245	286	279	279	Natural variant	ID=VAR_002485;Note=In NSHA%3B Chinese-1%3B class II. T->S
G6PD	P11413	245	286	282	282	Natural variant	ID=VAR_002486;Note=In NSHA%3B Seattle%3B class III. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2912069;Dbxref=dbSNP:rs137852318,PMID:2912069
G6PD	P11413	245	286	285	285	Natural variant	ID=VAR_002487;Note=In NSHA%3B Montalbano%3B class III. R->H;Dbxref=dbSNP:rs74575103
G6PD	P11413	455	485	459	459	Natural variant	ID=VAR_002512;Note=In NSHA%3B Canton%3B class II%3B frequent in China. R->L;Dbxref=dbSNP:rs72554665
G6PD	P11413	455	485	459	459	Natural variant	ID=VAR_002513;Note=In NSHA%3B Cosenza%3B class II. R->P;Dbxref=dbSNP:rs72554665
G6PD	P11413	455	485	463	463	Natural variant	ID=VAR_002514;Note=In NSHA%3B Kaiping%3B class II. R->H;Dbxref=dbSNP:rs72554664
G6PD	P11413	485	515	488	488	Natural variant	ID=VAR_002515;Note=In NSHA%3B Campinas%3B class I. G->V
G6PD	P11413	162	214	171	171	Mutagenesis	Note=Inhibits catalytic activity. Does not impair dimerization. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24769394;Dbxref=PMID:24769394
G6PD	P11413	162	214	171	171	Mutagenesis	Note=Inhibits catalytic activity. Does not impair dimerization. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24769394;Dbxref=PMID:24769394
G6PD	P11413	162	214	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	162	214	165	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	162	214	177	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	193	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	162	214	193	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	162	214	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	201	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	162	214	201	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	206	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	206	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	162	214	206	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	219	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	219	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	222	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BHL
G6PD	P11413	215	256	222	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BHL
G6PD	P11413	192	244	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	192	244	230	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	230	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	247	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	247	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	251	253	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	251	253	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	254	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	215	256	254	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	259	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	263	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	277	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	245	286	281	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	455	485	455	475	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	455	485	480	483	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
G6PD	P11413	485	515	486	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BH9
G6PD	P11413	485	515	490	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6E08
GADD45B	O75293	15	48	1	160	Chain	ID=PRO_0000148334;Note=Growth arrest and DNA damage-inducible protein GADD45 beta
GABPB1	Q06547	0	36	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
GABPB1	Q06547	244	306	2	395	Chain	ID=PRO_0000066993;Note=GA-binding protein subunit beta-1
GABPB1	Q06547	92	157	2	395	Chain	ID=PRO_0000066993;Note=GA-binding protein subunit beta-1
GABPB1	Q06547	0	36	2	395	Chain	ID=PRO_0000066993;Note=GA-binding protein subunit beta-1
GABPB1	Q06547	0	36	5	34	Repeat	Note=ANK 1
GABPB1	Q06547	92	157	70	99	Repeat	Note=ANK 3
GABPB1	Q06547	92	157	103	132	Repeat	Note=ANK 4
GABPB1	Q06547	92	157	136	166	Repeat	Note=ANK 5
GABPB1	Q06547	244	306	258	327	Region	Note=Transcription activation and HCFC1 interaction
GABPB1	Q06547	0	36	2	2	Modified residue	Note=N-acetylserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
GABPB1	Q06547	0	36	31	31	Natural variant	ID=VAR_035613;Note=In a colorectal cancer sample%3B somatic mutation. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
GABPB1	Q06547	244	306	262	263	Mutagenesis	Note=Minor reduction in transcriptional activation%3B when associated with A-295 or A-305 and A-306. QQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8816484;Dbxref=PMID:8816484
GABPB1	Q06547	244	306	264	265	Mutagenesis	Note=Minor effect upon interaction with HCFC1 and transcriptional activation. Loss of activity%3B when associated with A-297%3B A-298 and A-299%2C or with A-307 and A-310. VV->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10675337,ECO:0000269|PubMed:8816484;Dbxref=PMID:10675337,PMID:8816484
GABPB1	Q06547	244	306	270	271	Mutagenesis	Note=Minor reduction in transcriptional activation. Moderate reduction in activity%3B when associated with A-305 and A-306. QQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8816484;Dbxref=PMID:8816484
GABPB1	Q06547	244	306	273	275	Mutagenesis	Note=Strongly reduces interaction with HCFC1 and transcriptional activation. Loss of activity%3B when associated with A-297%3B A-298 and A-299%2C or with A-307 and A-310. ITI->ATA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10675337,ECO:0000269|PubMed:8816484;Dbxref=PMID:10675337,PMID:8816484
GABPB1	Q06547	244	306	295	295	Mutagenesis	Note=No effect on transcriptional activation. Minor reduction in activity%3B when associated with A-270 and A-271. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8816484;Dbxref=PMID:8816484
GABPB1	Q06547	244	306	297	299	Mutagenesis	Note=Strongly reduces interaction with HCFC1 and transcriptional activation. Loss of activity%3B when associated with A-264 and A-265%2C or A-273 and A-275. IIV->AAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10675337,ECO:0000269|PubMed:8816484;Dbxref=PMID:10675337,PMID:8816484
GABPB1	Q06547	244	306	305	306	Mutagenesis	Note=Minor reduction in transcriptional activation. Moderate reduction in activity%3B when associated with A-270 and A-271. QQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8816484;Dbxref=PMID:8816484
GABPB1	Q06547	244	306	246	246	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABPB1	Q06547	244	306	274	274	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
GALC	P54803	194	207	43	685	Chain	ID=PRO_0000012230;Note=Galactocerebrosidase
GALC	P54803	65	88	43	685	Chain	ID=PRO_0000012230;Note=Galactocerebrosidase
GALC	P54803	194	207	198	198	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALC	P54803	194	207	197	197	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALC	P54803	65	88	1	65	Alternative sequence	ID=VSP_036974;Note=In isoform 4. MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGAVSGGG->MLGKSHGRATHGPLPLADLGIHLPCVKVLHQVTPEEKPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GALC	P54803	65	88	1	65	Alternative sequence	ID=VSP_036975;Note=In isoform 5. MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGAVSGGG->MGFMVADLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GALC	P54803	65	88	66	88	Alternative sequence	ID=VSP_036976;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GALC	P54803	65	88	68	68	Natural variant	ID=VAR_013957;Note=In GLD%3B infantile%3B significant reduction of activity. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10234611;Dbxref=PMID:10234611
GALC	P54803	65	88	79	79	Natural variant	ID=VAR_013958;Note=In GLD. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8940268;Dbxref=dbSNP:rs370117160,PMID:8940268
GALC	P54803	65	88	82	82	Natural variant	ID=VAR_013959;Note=In GLD%3B adult%3B reduction of activity%3B when associated with V-2105. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9272171;Dbxref=PMID:9272171
GALC	P54803	194	207	194	194	Natural variant	ID=VAR_003385;Note=In GLD. G->A;Dbxref=dbSNP:rs963756824
GALC	P54803	65	88	78	78	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
GALC	P54803	194	207	195	195	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GALNT1	Q10472	433	466	1	559	Chain	ID=PRO_0000223387;Note=Polypeptide N-acetylgalactosaminyltransferase 1
GALNT1	Q10472	433	466	41	559	Chain	ID=PRO_0000012257;Note=Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
GALNT1	Q10472	433	466	29	559	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT1	Q10472	433	466	429	551	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT1	Q10472	433	466	442	459	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT1	Q10472	433	466	106	559	Alternative sequence	ID=VSP_011200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GBP2	P32456	208	289	1	588	Chain	ID=PRO_0000190964;Note=Guanylate-binding protein 2
GBP2	P32456	208	289	35	276	Domain	Note=GB1/RHD3-type G
GBP2	P32456	208	289	1	309	Region	Note=GTPase domain (Globular);Ontology_term=ECO:0000250;evidence=ECO:0000250
GBP2	P32456	208	289	281	281	Natural variant	ID=VAR_054815;Note=S->P;Dbxref=dbSNP:rs2230336
GBP2	P32456	208	289	285	285	Natural variant	ID=VAR_054816;Note=P->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1715024,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1803632,PMID:14702039,PMID:1715024,PMID:17974005
TUBGCP2	Q9BSJ2	763	803	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	715	763	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	632	674	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	93	152	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	763	803	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	715	763	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	632	674	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	93	152	1	902	Chain	ID=PRO_0000078113;Note=Gamma-tubulin complex component 2
TUBGCP2	Q9BSJ2	93	152	109	112	Compositional bias	Note=Poly-Ala
TUBGCP2	Q9BSJ2	93	152	109	112	Compositional bias	Note=Poly-Ala
TUBGCP2	Q9BSJ2	93	152	1	130	Alternative sequence	ID=VSP_044698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TUBGCP2	Q9BSJ2	93	152	1	130	Alternative sequence	ID=VSP_044698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TUBGCP2	Q9BSJ2	93	152	111	111	Natural variant	ID=VAR_022126;Note=A->T;Dbxref=dbSNP:rs2298121
TUBGCP2	Q9BSJ2	93	152	111	111	Natural variant	ID=VAR_022126;Note=A->T;Dbxref=dbSNP:rs2298121
TUBGCP2	Q9BSJ2	632	674	641	641	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TUBGCP2	Q9BSJ2	632	674	641	641	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACBD3	Q9H3P7	363	458	1	528	Chain	ID=PRO_0000436449;Note=Golgi resident protein GCP60
ACBD3	Q9H3P7	143	189	1	528	Chain	ID=PRO_0000436449;Note=Golgi resident protein GCP60
ACBD3	Q9H3P7	363	458	2	528	Chain	ID=PRO_0000214029;Note=Golgi resident protein GCP60%2C N-terminally processed
ACBD3	Q9H3P7	143	189	2	528	Chain	ID=PRO_0000214029;Note=Golgi resident protein GCP60%2C N-terminally processed
ACBD3	Q9H3P7	143	189	83	174	Domain	Note=ACB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00573
ACBD3	Q9H3P7	363	458	384	526	Domain	Note=GOLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00096
ACBD3	Q9H3P7	143	189	174	257	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ACBD3	Q9H3P7	143	189	182	240	Compositional bias	Note=Glu-rich
ACBD3	Q9H3P7	143	189	187	187	Natural variant	ID=VAR_019615;Note=E->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2306120,PMID:14702039
ACBD3	Q9H3P7	363	458	380	381	Mutagenesis	Note=No effect on interaction with PI4KB but loss of interaction with Kobuviral (Aichi) 3A protein. Loss of ability to sensitize PI4KB activation by Kobuviral (Aichi) 3A protein. IK->AE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27989622;Dbxref=PMID:27989622
ACBD3	Q9H3P7	363	458	414	416	Mutagenesis	Note=No effect on PI4KB-%2C TBC1D22A- and TBC1D22B-binding. SYL->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572552;Dbxref=PMID:23572552
ACBD3	Q9H3P7	363	458	417	420	Mutagenesis	Note=No effect on PI4KB-%2C TBC1D22A- and TBC1D22B-binding. FWEF->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572552;Dbxref=PMID:23572552
ACBD3	Q9H3P7	363	458	433	435	Mutagenesis	Note=No effect on PI4KB-%2C TBC1D22A- and TBC1D22B-binding. FEW->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572552;Dbxref=PMID:23572552
ACBD3	Q9H3P7	363	458	384	397	Sequence conflict	Note=KEKIQQDADSVITV->QREDSAGCRFRDYS;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACBD3	Q9H3P7	363	458	425	425	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACBD3	Q9H3P7	363	458	373	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	380	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	391	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	394	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	402	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	414	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	423	425	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	427	434	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
ACBD3	Q9H3P7	363	458	444	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LZ1
NR3C1	P04150	450	489	1	777	Chain	ID=PRO_0000019937;Note=Glucocorticoid receptor
NR3C1	P04150	450	489	1	777	Chain	ID=PRO_0000019937;Note=Glucocorticoid receptor
NR3C1	P04150	450	489	1	777	Chain	ID=PRO_0000019937;Note=Glucocorticoid receptor
NR3C1	P04150	450	489	418	493	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR3C1	P04150	450	489	418	493	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR3C1	P04150	450	489	418	493	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR3C1	P04150	450	489	457	476	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR3C1	P04150	450	489	457	476	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR3C1	P04150	450	489	457	476	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR3C1	P04150	450	489	485	777	Region	Note=Interaction with CLOCK
NR3C1	P04150	450	489	485	777	Region	Note=Interaction with CLOCK
NR3C1	P04150	450	489	485	777	Region	Note=Interaction with CLOCK
NR3C1	P04150	450	489	487	523	Region	Note=Hinge
NR3C1	P04150	450	489	487	523	Region	Note=Hinge
NR3C1	P04150	450	489	487	523	Region	Note=Hinge
NR3C1	P04150	450	489	480	480	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19141540;Dbxref=PMID:19141540
NR3C1	P04150	450	489	480	480	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19141540;Dbxref=PMID:19141540
NR3C1	P04150	450	489	480	480	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19141540;Dbxref=PMID:19141540
NR3C1	P04150	450	489	451	451	Alternative sequence	ID=VSP_007363;Note=In isoform Alpha-2 and isoform Beta-2. G->GR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
NR3C1	P04150	450	489	451	451	Alternative sequence	ID=VSP_007363;Note=In isoform Alpha-2 and isoform Beta-2. G->GR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
NR3C1	P04150	450	489	451	451	Alternative sequence	ID=VSP_007363;Note=In isoform Alpha-2 and isoform Beta-2. G->GR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
NR3C1	P04150	450	489	477	477	Natural variant	ID=VAR_013472;Note=In GCCR. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11589680;Dbxref=dbSNP:rs104893913,PMID:11589680
NR3C1	P04150	450	489	477	477	Natural variant	ID=VAR_013472;Note=In GCCR. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11589680;Dbxref=dbSNP:rs104893913,PMID:11589680
NR3C1	P04150	450	489	477	477	Natural variant	ID=VAR_013472;Note=In GCCR. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11589680;Dbxref=dbSNP:rs104893913,PMID:11589680
NR3C1	P04150	450	489	477	477	Natural variant	ID=VAR_077143;Note=In GCCR%3B loss of DNA-binding and of transactivation activity%3B incomplete dexamethasone-induced translocation to the nucleus%3B no effect on dexamethasone-binding affinity compared with wild-type. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120390;Dbxref=PMID:27120390
NR3C1	P04150	450	489	477	477	Natural variant	ID=VAR_077143;Note=In GCCR%3B loss of DNA-binding and of transactivation activity%3B incomplete dexamethasone-induced translocation to the nucleus%3B no effect on dexamethasone-binding affinity compared with wild-type. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120390;Dbxref=PMID:27120390
NR3C1	P04150	450	489	477	477	Natural variant	ID=VAR_077143;Note=In GCCR%3B loss of DNA-binding and of transactivation activity%3B incomplete dexamethasone-induced translocation to the nucleus%3B no effect on dexamethasone-binding affinity compared with wild-type. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120390;Dbxref=PMID:27120390
NR3C1	P04150	450	489	478	478	Natural variant	ID=VAR_077144;Note=In GCCR%3B decreased DNA-binding and transactivation activity%3B incomplete dexamethasone-induced translocation to the nucleus%3B no effect on dexamethasone-binding affinity compared with wild-type. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120390;Dbxref=PMID:27120390
NR3C1	P04150	450	489	478	478	Natural variant	ID=VAR_077144;Note=In GCCR%3B decreased DNA-binding and transactivation activity%3B incomplete dexamethasone-induced translocation to the nucleus%3B no effect on dexamethasone-binding affinity compared with wild-type. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120390;Dbxref=PMID:27120390
NR3C1	P04150	450	489	478	478	Natural variant	ID=VAR_077144;Note=In GCCR%3B decreased DNA-binding and transactivation activity%3B incomplete dexamethasone-induced translocation to the nucleus%3B no effect on dexamethasone-binding affinity compared with wild-type. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120390;Dbxref=PMID:27120390
NR3C1	P04150	450	489	480	480	Mutagenesis	Note=Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer%3B when associated with A-492%3B A-494 and A-495. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19141540;Dbxref=PMID:19141540
NR3C1	P04150	450	489	480	480	Mutagenesis	Note=Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer%3B when associated with A-492%3B A-494 and A-495. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19141540;Dbxref=PMID:19141540
NR3C1	P04150	450	489	480	480	Mutagenesis	Note=Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer%3B when associated with A-492%3B A-494 and A-495. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19141540;Dbxref=PMID:19141540
NR3C1	P04150	450	489	439	450	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	439	450	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	439	450	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	467	472	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	467	472	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	467	472	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	474	484	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	474	484	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
NR3C1	P04150	450	489	474	484	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E69
ARHGDIB	P52566	60	88	2	201	Chain	ID=PRO_0000219016;Note=Rho GDP-dissociation inhibitor 2
ARHGDIB	P52566	60	88	2	201	Chain	ID=PRO_0000219016;Note=Rho GDP-dissociation inhibitor 2
ARHGDIB	P52566	60	88	2	201	Chain	ID=PRO_0000219016;Note=Rho GDP-dissociation inhibitor 2
ARHGDIB	P52566	60	88	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DS6
ARHGDIB	P52566	60	88	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DS6
ARHGDIB	P52566	60	88	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DS6
ARHGDIB	P52566	60	88	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	84	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	84	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
ARHGDIB	P52566	60	88	84	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H1D
GDPD1	Q8N9F7	162	192	1	314	Chain	ID=PRO_0000251931;Note=Lysophospholipase D GDPD1
GDPD1	Q8N9F7	237	256	1	314	Chain	ID=PRO_0000251931;Note=Lysophospholipase D GDPD1
GDPD1	Q8N9F7	162	192	25	195	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD1	Q8N9F7	237	256	217	314	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD1	Q8N9F7	162	192	40	309	Domain	Note=GP-PDE
GDPD1	Q8N9F7	237	256	40	309	Domain	Note=GP-PDE
GGT7	Q9UJ14	529	575	473	662	Chain	ID=PRO_0000011067;Note=Glutathione hydrolase 7 light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
GGT7	Q9UJ14	529	575	128	662	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT7	Q9UJ14	529	575	252	662	Alternative sequence	ID=VSP_008137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12270127;Dbxref=PMID:12270127
GGT7	Q9UJ14	529	575	290	662	Alternative sequence	ID=VSP_008139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GGT7	Q9UJ14	529	575	426	662	Alternative sequence	ID=VSP_008141;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
GOLGA6L4	A6NEF3	68	88	1	574	Chain	ID=PRO_0000332264;Note=Golgin subfamily A member 6-like protein 4
GIPC2	Q8TF65	80	142	1	315	Chain	ID=PRO_0000247188;Note=PDZ domain-containing protein GIPC2
GIPC2	Q8TF65	80	142	117	197	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
GIPC2	Q8TF65	80	142	113	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGE
GIPC2	Q8TF65	80	142	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGE
GIPC2	Q8TF65	80	142	134	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGE
GIPC2	Q8TF65	80	142	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGE
GIT1	Q9Y2X7	555	584	1	761	Chain	ID=PRO_0000074200;Note=ARF GTPase-activating protein GIT1
GIT1	Q9Y2X7	537	555	1	761	Chain	ID=PRO_0000074200;Note=ARF GTPase-activating protein GIT1
GIT1	Q9Y2X7	537	555	537	537	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6
GIT1	Q9Y2X7	537	555	545	545	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
GIT1	Q9Y2X7	537	555	554	554	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
GIT1	Q9Y2X7	555	584	561	561	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6
GIT1	Q9Y2X7	555	584	571	571	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z272
GIT1	Q9Y2X7	555	584	177	761	Alternative sequence	ID=VSP_009667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GIT1	Q9Y2X7	537	555	177	761	Alternative sequence	ID=VSP_009667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GKAP1	Q5VSY0	195	246	1	366	Chain	ID=PRO_0000315654;Note=G kinase-anchoring protein 1
GKAP1	Q5VSY0	120	146	1	366	Chain	ID=PRO_0000315654;Note=G kinase-anchoring protein 1
GKAP1	Q5VSY0	120	146	128	160	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GKAP1	Q5VSY0	195	246	243	353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GKAP1	Q5VSY0	195	246	196	246	Alternative sequence	ID=VSP_030596;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10671526;Dbxref=PMID:10671526
GLIS3	Q8NEA6	669	730	1	775	Chain	ID=PRO_0000047211;Note=Zinc finger protein GLIS3
GMDS	O60547	179	214	2	372	Chain	ID=PRO_0000201705;Note=GDP-mannose 4%2C6 dehydratase
GMDS	O60547	179	214	179	179	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
GMDS	O60547	179	214	183	183	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.9
GMDS	O60547	179	214	209	209	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.9
GMDS	O60547	179	214	214	214	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.9
GMDS	O60547	179	214	178	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IN4
GMDS	O60547	179	214	200	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IN4
HKDC1	Q2TB90	292	343	1	917	Chain	ID=PRO_0000299035;Note=Putative hexokinase HKDC1
HKDC1	Q2TB90	612	644	1	917	Chain	ID=PRO_0000299035;Note=Putative hexokinase HKDC1
HKDC1	Q2TB90	292	343	16	458	Domain	Note=Hexokinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HKDC1	Q2TB90	612	644	464	905	Domain	Note=Hexokinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HKDC1	Q2TB90	292	343	208	447	Region	Note=Hexokinase large subdomain 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HKDC1	Q2TB90	612	644	521	654	Region	Note=Hexokinase small subdomain 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HKDC1	Q2TB90	612	644	596	622	Region	Note=Glucose-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
GNPTAB	Q3T906	469	537	1	928	Chain	ID=PRO_0000225008;Note=N-acetylglucosamine-1-phosphotransferase subunit alpha
GNPTAB	Q3T906	108	121	1	928	Chain	ID=PRO_0000225008;Note=N-acetylglucosamine-1-phosphotransferase subunit alpha
GNPTAB	Q3T906	68	107	1	928	Chain	ID=PRO_0000225008;Note=N-acetylglucosamine-1-phosphotransferase subunit alpha
GNPTAB	Q3T906	1145	1200	929	1256	Chain	ID=PRO_0000225009;Note=N-acetylglucosamine-1-phosphotransferase subunit beta
GNPTAB	Q3T906	1045	1083	929	1256	Chain	ID=PRO_0000225009;Note=N-acetylglucosamine-1-phosphotransferase subunit beta
GNPTAB	Q3T906	469	537	438	473	Repeat	Note=LNR 1
GNPTAB	Q3T906	469	537	505	545	Repeat	Note=LNR 2
GNPTAB	Q3T906	469	537	465	498	Compositional bias	Note=Gly-rich
GNPTAB	Q3T906	469	537	516	516	Metal binding	Note=Calcium;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00525
GNPTAB	Q3T906	469	537	531	531	Metal binding	Note=Calcium;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00525
GNPTAB	Q3T906	469	537	534	534	Metal binding	Note=Calcium;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00525
GNPTAB	Q3T906	68	107	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GNPTAB	Q3T906	108	121	114	114	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GNPTAB	Q3T906	469	537	505	528	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00525
GNPTAB	Q3T906	469	537	519	535	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00525
GNPTAB	Q3T906	469	537	471	490	Alternative sequence	ID=VSP_017338;Note=In isoform 2. NSGGSRYIAGGGGTGSIGVG->KDVLNCNSFIFMEYFLLNHY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GNPTAB	Q3T906	1145	1200	491	1256	Alternative sequence	ID=VSP_017339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GNPTAB	Q3T906	1045	1083	491	1256	Alternative sequence	ID=VSP_017339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GNPTAB	Q3T906	469	537	491	1256	Alternative sequence	ID=VSP_017339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GNPTAB	Q3T906	68	107	76	76	Natural variant	ID=VAR_079713;Note=In MLII%3B loss of Golgi localization%3B defects in protein cleavage into alpha and beta subunits%3B loss of UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28918368;Dbxref=PMID:28918368
GNPTAB	Q3T906	68	107	81	81	Natural variant	ID=VAR_070831;Note=In MLII and MLIIIA%3B no effect on protein abundance%3B decreased localization to the Golgi%3B defects in protein cleavage into alpha and beta subunits%3B loss of UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. W->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23566849,ECO:0000269|PubMed:24375680,ECO:0000269|PubMed:25505245,ECO:0000269|PubMed:28918368;Dbxref=dbSNP:rs281864953,PMID:23566849,PMID:24375680,PMID:25505245,PMID:28918368
GNPTAB	Q3T906	1145	1200	278	1256	Natural variant	ID=VAR_079714;Note=In MLIIIA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28918368;Dbxref=PMID:28918368
GNPTAB	Q3T906	1045	1083	278	1256	Natural variant	ID=VAR_079714;Note=In MLIIIA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28918368;Dbxref=PMID:28918368
GNPTAB	Q3T906	469	537	278	1256	Natural variant	ID=VAR_079714;Note=In MLIIIA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28918368;Dbxref=PMID:28918368
GNPTAB	Q3T906	469	537	505	505	Natural variant	ID=VAR_070832;Note=In MLIIIA%3B unknown pathological significance%3B decreased localization to the Golgi%3B decreased protein cleavage into alpha and beta subunits%3B decreased UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity%3B reduces protein abundance. C->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19617216,ECO:0000269|PubMed:23566849,ECO:0000269|PubMed:25505245,ECO:0000269|PubMed:25788519,ECO:0000269|PubMed:28918368;Dbxref=dbSNP:rs281864980,PMID:19617216,PMID:23566849,PMID:25505245,PMID:25788519,PMID:28918368
GNPTAB	Q3T906	469	537	523	523	Natural variant	ID=VAR_073130;Note=Found in a patient with mucolipidosis type II or III%3B unknown pathological significance%3B decreased localization to the Golgi%3B decreased protein cleavage into alpha and beta subunits%3B decreased UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24798265,ECO:0000269|PubMed:25505245;Dbxref=PMID:24798265,PMID:25505245
GNPTAB	Q3T906	1045	1083	1054	1054	Natural variant	ID=VAR_073138;Note=In MLII%3B unknown pathological significance%3B no effect on localization to the Golgi%3B decreased UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19938078,ECO:0000269|PubMed:25505245;Dbxref=dbSNP:rs281865010,PMID:19938078,PMID:25505245
GNPTAB	Q3T906	1145	1200	1111	1256	Natural variant	ID=VAR_079716;Note=In MLII. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28918368;Dbxref=PMID:28918368
GNPTAB	Q3T906	1145	1200	1153	1153	Natural variant	ID=VAR_062815;Note=In MLIIIA%3B no effect on protein abundance%3B no effect on localization to the Golgi%3B loss of UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19197337,ECO:0000269|PubMed:25505245;Dbxref=dbSNP:rs281865019,PMID:19197337,PMID:25505245
GNPTAB	Q3T906	1145	1200	1200	1200	Natural variant	ID=VAR_073221;Note=Polymorphism%3B may be a risk factor for stuttering. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20147709,ECO:0000269|PubMed:27535533;Dbxref=dbSNP:rs137853825,PMID:20147709,PMID:27535533
GPATCH11	Q8N954	117	131	1	285	Chain	ID=PRO_0000279751;Note=G patch domain-containing protein 11
GPATCH11	Q8N954	117	131	95	141	Domain	Note=G-patch;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00092
GPATCH11	Q8N954	117	131	1	129	Alternative sequence	ID=VSP_023505;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
GPATCH11	Q8N954	117	131	130	132	Alternative sequence	ID=VSP_023506;Note=In isoform 2. KTG->MSR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
GRB14	Q14449	341	368	2	540	Chain	ID=PRO_0000150348;Note=Growth factor receptor-bound protein 14
GRB14	Q14449	309	341	2	540	Chain	ID=PRO_0000150348;Note=Growth factor receptor-bound protein 14
GRB14	Q14449	201	226	2	540	Chain	ID=PRO_0000150348;Note=Growth factor receptor-bound protein 14
GRB14	Q14449	341	368	234	342	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
GRB14	Q14449	309	341	234	342	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
GRB14	Q14449	341	368	348	348	Mutagenesis	Note=Loss of inhibition of AKT1 activation%3B when associated with A-349. Loss of inhibition of MAPK3 phosphorylation%3B when associated with A-349. No effect on INSR-binding%3B when associated with A-349. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19648926;Dbxref=PMID:19648926
GRB14	Q14449	341	368	349	349	Mutagenesis	Note=Loss of inhibition of AKT1 activation%3B when associated with A-348. Loss of inhibition of MAPK3 phosphorylation%3B when associated with A-348. No effect on INSR-binding%3B when associated with A-348. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19648926;Dbxref=PMID:19648926
GRB14	Q14449	201	226	201	203	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	201	226	206	208	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	201	226	221	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	309	341	305	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	309	341	312	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	309	341	320	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	341	368	327	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	309	341	327	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB14	Q14449	341	368	344	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K81
GRB2	P62993	59	99	1	217	Chain	ID=PRO_0000088198;Note=Growth factor receptor-bound protein 2
GRB2	P62993	59	99	1	217	Chain	ID=PRO_0000088198;Note=Growth factor receptor-bound protein 2
GRB2	P62993	59	99	1	217	Chain	ID=PRO_0000088198;Note=Growth factor receptor-bound protein 2
GRB2	P62993	59	99	60	152	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
GRB2	P62993	59	99	60	152	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
GRB2	P62993	59	99	60	152	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
GRB2	P62993	59	99	60	100	Alternative sequence	ID=VSP_001839;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8178156;Dbxref=PMID:8178156
GRB2	P62993	59	99	60	100	Alternative sequence	ID=VSP_001839;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8178156;Dbxref=PMID:8178156
GRB2	P62993	59	99	60	100	Alternative sequence	ID=VSP_001839;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8178156;Dbxref=PMID:8178156
GRB2	P62993	59	99	89	89	Mutagenesis	Note=No effect on the interaction with SOS1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8493579;Dbxref=PMID:8493579
GRB2	P62993	59	99	89	89	Mutagenesis	Note=No effect on the interaction with SOS1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8493579;Dbxref=PMID:8493579
GRB2	P62993	59	99	89	89	Mutagenesis	Note=No effect on the interaction with SOS1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8493579;Dbxref=PMID:8493579
GRB2	P62993	59	99	90	90	Mutagenesis	Note=No effect on the interaction with SOS1. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8493579;Dbxref=PMID:8493579
GRB2	P62993	59	99	90	90	Mutagenesis	Note=No effect on the interaction with SOS1. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8493579;Dbxref=PMID:8493579
GRB2	P62993	59	99	90	90	Mutagenesis	Note=No effect on the interaction with SOS1. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8493579;Dbxref=PMID:8493579
GRB2	P62993	59	99	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IMD
GRB2	P62993	59	99	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IMD
GRB2	P62993	59	99	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IMD
GRB2	P62993	59	99	67	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	67	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	67	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FHS
GRB2	P62993	59	99	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FHS
GRB2	P62993	59	99	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FHS
GRB2	P62993	59	99	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	89	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	89	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	89	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	95	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	95	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRB2	P62993	59	99	95	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WA4
GRAP2	O75791	57	96	1	330	Chain	ID=PRO_0000088208;Note=GRB2-related adapter protein 2
GRAP2	O75791	57	96	1	330	Chain	ID=PRO_0000088208;Note=GRB2-related adapter protein 2
GRAP2	O75791	57	96	58	149	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
GRAP2	O75791	57	96	58	149	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
GRAP2	O75791	57	96	40	152	Alternative sequence	ID=VSP_055235;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRAP2	O75791	57	96	40	152	Alternative sequence	ID=VSP_055235;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRAP2	O75791	57	96	65	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	65	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	80	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	80	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	91	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRAP2	O75791	57	96	91	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJH
GRIA4	P48058	82	162	21	902	Chain	ID=PRO_0000011538;Note=Glutamate receptor 4
GRIA4	P48058	82	162	21	902	Chain	ID=PRO_0000011538;Note=Glutamate receptor 4
GRIA4	P48058	82	162	22	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA4	P48058	82	162	22	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA4	P48058	82	162	84	331	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA4	P48058	82	162	84	331	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4A2	Q14240	209	257	1	407	Chain	ID=PRO_0000054938;Note=Eukaryotic initiation factor 4A-II
EIF4A2	Q14240	303	333	1	407	Chain	ID=PRO_0000054938;Note=Eukaryotic initiation factor 4A-II
EIF4A2	Q14240	209	257	64	235	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A2	Q14240	209	257	246	407	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A2	Q14240	303	333	246	407	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A2	Q14240	209	257	212	213	Sequence conflict	Note=LL->FA;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4A2	Q14240	209	257	209	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BOR
EIF4A2	Q14240	209	257	219	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BOR
EIF4A2	Q14240	209	257	233	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BOR
EIF4A3	P38919	328	363	1	411	Chain	ID=PRO_0000423267;Note=Eukaryotic initiation factor 4A-III
EIF4A3	P38919	168	195	1	411	Chain	ID=PRO_0000423267;Note=Eukaryotic initiation factor 4A-III
EIF4A3	P38919	103	124	1	411	Chain	ID=PRO_0000423267;Note=Eukaryotic initiation factor 4A-III
EIF4A3	P38919	328	363	2	411	Chain	ID=PRO_0000054942;Note=Eukaryotic initiation factor 4A-III%2C N-terminally processed
EIF4A3	P38919	168	195	2	411	Chain	ID=PRO_0000054942;Note=Eukaryotic initiation factor 4A-III%2C N-terminally processed
EIF4A3	P38919	103	124	2	411	Chain	ID=PRO_0000054942;Note=Eukaryotic initiation factor 4A-III%2C N-terminally processed
EIF4A3	P38919	168	195	69	239	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A3	P38919	103	124	69	239	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A3	P38919	328	363	250	411	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A3	P38919	168	195	187	190	Motif	Note=DEAD box;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4A3	P38919	328	363	342	342	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2HYI,ECO:0000244|PDB:2J0Q,ECO:0000244|PDB:2J0S,ECO:0000244|PDB:2XB2,ECO:0000244|PDB:3EX7,ECO:0000269|PubMed:16923391,ECO:0000269|PubMed:16931718,ECO:0000269|PubMed:19033377;Dbxref=PMID:16923391,PMID:16931718,PMID:19033377
EIF4A3	P38919	103	124	124	124	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60842
EIF4A3	P38919	328	363	334	334	Mutagenesis	Note=Reduced incorporation into EJCs. T->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23236153;Dbxref=PMID:23236153
EIF4A3	P38919	103	124	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0U
EIF4A3	P38919	103	124	109	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	103	124	116	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	168	195	164	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	168	195	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	168	195	189	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	335	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0S
EIF4A3	P38919	328	363	338	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0S
EIF4A3	P38919	328	363	346	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	356	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	360	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
GDA	Q9Y2T3	202	238	1	454	Chain	ID=PRO_0000122298;Note=Guanine deaminase
GDA	Q9Y2T3	202	238	213	214	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:2UZ9,ECO:0000305|PubMed:22662200;Dbxref=PMID:22662200
GDA	Q9Y2T3	202	238	204	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AQL
GDA	Q9Y2T3	202	238	210	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AQL
GDA	Q9Y2T3	202	238	215	217	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AQL
GDA	Q9Y2T3	202	238	220	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AQL
GDA	Q9Y2T3	202	238	237	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AQL
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A2	Q9GZV4	90	134	2	153	Chain	ID=PRO_0000229764;Note=Eukaryotic translation initiation factor 5A-2
EIF5A2	Q9GZV4	55	90	2	153	Chain	ID=PRO_0000229764;Note=Eukaryotic translation initiation factor 5A-2
EIF5	P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
EIF5	P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
EIF5	P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
EIF5	P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF5	P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF5	P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF5	P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5	P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5	P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5	P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
HMGN5	P82970	25	43	1	282	Chain	ID=PRO_0000206717;Note=High mobility group nucleosome-binding domain-containing protein 5
HMGN5	P82970	15	25	1	282	Chain	ID=PRO_0000206717;Note=High mobility group nucleosome-binding domain-containing protein 5
HMGN5	P82970	5	15	1	282	Chain	ID=PRO_0000206717;Note=High mobility group nucleosome-binding domain-containing protein 5
HMGN5	P82970	25	43	31	31	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
HMCES	Q96FZ2	61	109	1	354	Chain	ID=PRO_0000164394;Note=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
HMCES	Q96FZ2	109	151	1	354	Chain	ID=PRO_0000164394;Note=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
HMCES	Q96FZ2	61	109	1	354	Chain	ID=PRO_0000164394;Note=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
HMCES	Q96FZ2	109	151	1	354	Chain	ID=PRO_0000164394;Note=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
HMCES	Q96FZ2	61	109	1	354	Chain	ID=PRO_0000164394;Note=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
HMCES	Q96FZ2	109	151	1	354	Chain	ID=PRO_0000164394;Note=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
HMCES	Q96FZ2	109	151	148	148	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HMCES	Q96FZ2	109	151	148	148	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HMCES	Q96FZ2	109	151	148	148	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HMCES	Q96FZ2	109	151	151	151	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HMCES	Q96FZ2	109	151	151	151	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HMCES	Q96FZ2	109	151	151	151	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HMCES	Q96FZ2	61	109	67	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	67	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	67	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	102	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	102	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	102	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	106	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	106	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	106	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	106	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	61	109	106	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	106	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	117	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	117	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	117	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMCES	Q96FZ2	109	151	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KO9
HMGCL	P35914	250	292	28	325	Chain	ID=PRO_0000013478;Note=Hydroxymethylglutaryl-CoA lyase%2C mitochondrial
HMGCL	P35914	187	250	28	325	Chain	ID=PRO_0000013478;Note=Hydroxymethylglutaryl-CoA lyase%2C mitochondrial
HMGCL	P35914	48	84	28	325	Chain	ID=PRO_0000013478;Note=Hydroxymethylglutaryl-CoA lyase%2C mitochondrial
HMGCL	P35914	250	292	33	300	Domain	Note=Pyruvate carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01151
HMGCL	P35914	187	250	33	300	Domain	Note=Pyruvate carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01151
HMGCL	P35914	48	84	33	300	Domain	Note=Pyruvate carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01151
HMGCL	P35914	250	292	266	266	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10115
HMGCL	P35914	187	250	233	233	Metal binding	Note=Divalent metal cation
HMGCL	P35914	187	250	235	235	Metal binding	Note=Divalent metal cation
HMGCL	P35914	250	292	275	275	Metal binding	Note=Divalent metal cation
HMGCL	P35914	48	84	48	48	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HMGCL	P35914	48	84	48	48	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P38060
HMGCL	P35914	187	250	117	187	Alternative sequence	ID=VSP_047444;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:21952825;Dbxref=PMID:14702039,PMID:21952825
HMGCL	P35914	250	292	188	250	Alternative sequence	ID=VSP_043788;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21952825;Dbxref=PMID:21952825
HMGCL	P35914	187	250	188	250	Alternative sequence	ID=VSP_043788;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21952825;Dbxref=PMID:21952825
HMGCL	P35914	48	84	48	48	Natural variant	ID=VAR_058441;Note=In HMGCLD%3B abolishes almost all enzymatic activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17459752;Dbxref=PMID:17459752
HMGCL	P35914	48	84	70	70	Natural variant	ID=VAR_003748;Note=In HMGCLD. V->L;Dbxref=dbSNP:rs121964996
HMGCL	P35914	48	84	75	75	Natural variant	ID=VAR_058442;Note=In HMGCLD. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12746442;Dbxref=dbSNP:rs1357942068,PMID:12746442
HMGCL	P35914	187	250	192	192	Natural variant	ID=VAR_058445;Note=In HMGCLD%3B activity lower than 5%25 respect to the wild-type. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19177531;Dbxref=PMID:19177531
HMGCL	P35914	187	250	200	200	Natural variant	ID=VAR_058446;Note=In HMGCLD%3B activity lower than 5%25 respect to the wild-type. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19177531;Dbxref=PMID:19177531
HMGCL	P35914	187	250	201	201	Natural variant	ID=VAR_058447;Note=In HMGCLD. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12746442;Dbxref=dbSNP:rs760106433,PMID:12746442
HMGCL	P35914	187	250	203	203	Natural variant	ID=VAR_058448;Note=In HMGCLD%3B complete loss of activity. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16601870;Dbxref=PMID:16601870
HMGCL	P35914	187	250	204	204	Natural variant	ID=VAR_058449;Note=In HMGCLD. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12746442;Dbxref=PMID:12746442
HMGCL	P35914	187	250	233	233	Natural variant	ID=VAR_003749;Note=In HMGCLD%3B loss of activity. H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19177531,ECO:0000269|PubMed:8798725,ECO:0000269|PubMed:9784232;Dbxref=dbSNP:rs727503963,PMID:19177531,PMID:8798725,PMID:9784232
HMGCL	P35914	250	292	263	263	Natural variant	ID=VAR_058450;Note=In HMGCLD. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9784232;Dbxref=PMID:9784232
HMGCL	P35914	250	292	279	279	Natural variant	ID=VAR_014202;Note=In HMGCLD. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11129331;Dbxref=dbSNP:rs121964998,PMID:11129331
HMGCL	P35914	48	84	72	72	Mutagenesis	Note=Loss of activity%2C and reduced affinity for metal cofactor and substrate. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12874287;Dbxref=PMID:12874287
HMGCL	P35914	187	250	204	204	Mutagenesis	Note=Reduced activity%2C and reduced affinity for metal cofactor and substrate. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12874287;Dbxref=PMID:12874287
HMGCL	P35914	187	250	233	233	Mutagenesis	Note=Loss of activity%2C and reduced proton exchange rate. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12874287,ECO:0000269|PubMed:15122894;Dbxref=PMID:12874287,PMID:15122894
HMGCL	P35914	250	292	266	266	Mutagenesis	Note=Loss of activity. C->A
HMGCL	P35914	250	292	279	279	Mutagenesis	Note=Reduced thermal stability%2C but normal activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12874287;Dbxref=PMID:12874287
HMGCL	P35914	250	292	280	280	Mutagenesis	Note=Normal activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12874287;Dbxref=PMID:12874287
HMGCL	P35914	187	250	243	243	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMGCL	P35914	48	84	53	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	48	84	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	48	84	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	48	84	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	187	250	182	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	187	250	198	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	187	250	211	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	187	250	227	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	187	250	230	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	250	292	241	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	187	250	241	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	250	292	255	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
HMGCL	P35914	250	292	278	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW6
MAMSTR	Q6ZN01	176	241	1	415	Chain	ID=PRO_0000319981;Note=MEF2-activating motif and SAP domain-containing transcriptional regulator
MAMSTR	Q6ZN01	19	32	1	415	Chain	ID=PRO_0000319981;Note=MEF2-activating motif and SAP domain-containing transcriptional regulator
MAMSTR	Q6ZN01	176	241	172	206	Domain	Note=SAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00186
MAMSTR	Q6ZN01	176	241	215	415	Region	Note=Transcription activation;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAMSTR	Q6ZN01	19	32	12	28	Motif	Note=MEF2-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAMSTR	Q6ZN01	176	241	36	392	Compositional bias	Note=Pro-rich
MAMSTR	Q6ZN01	19	32	1	103	Alternative sequence	ID=VSP_031554;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MAMSTR	Q6ZN01	176	241	178	242	Alternative sequence	ID=VSP_031555;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HUS1	O60921	213	253	1	280	Chain	ID=PRO_0000225003;Note=Checkpoint protein HUS1
HUS1	O60921	119	155	1	280	Chain	ID=PRO_0000225003;Note=Checkpoint protein HUS1
HUS1	O60921	119	155	126	126	Natural variant	ID=VAR_033999;Note=S->G;Dbxref=dbSNP:rs2307261
HUS1	O60921	119	155	147	147	Natural variant	ID=VAR_025414;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7;Dbxref=dbSNP:rs2307254
HUS1	O60921	213	253	221	221	Natural variant	ID=VAR_025415;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7;Dbxref=dbSNP:rs3176588
HUS1	O60921	119	155	112	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	119	155	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	119	155	128	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	119	155	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGR
HUS1	O60921	119	155	140	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	119	155	155	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	213	253	216	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGR
HUS1	O60921	213	253	228	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	213	253	234	243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HUS1	O60921	213	253	249	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
HAL	P42357	506	551	1	657	Chain	ID=PRO_0000161058;Note=Histidine ammonia-lyase
HAL	P42357	506	551	549	549	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCOLN1	Q9GZU1	412	453	1	580	Chain	ID=PRO_0000215362;Note=Mucolipin-1
MCOLN1	Q9GZU1	412	453	406	427	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29019983;Dbxref=PMID:29019983
MCOLN1	Q9GZU1	412	453	428	448	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29019983;Dbxref=PMID:29019983
MCOLN1	Q9GZU1	412	453	449	456	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29019983;Dbxref=PMID:29019983
MCOLN1	Q9GZU1	412	453	446	446	Natural variant	ID=VAR_019373;Note=In ML4%3B does not affect channel activity%3B affects channel inhibition by low pH%3B impairs Fe(2+) permeability. V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11030752,ECO:0000269|PubMed:14749347,ECO:0000269|PubMed:18794901;Dbxref=dbSNP:rs754097561,PMID:11030752,PMID:14749347,PMID:18794901
MCOLN1	Q9GZU1	412	453	447	447	Natural variant	ID=VAR_019374;Note=In ML4. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12182165;Dbxref=dbSNP:rs797044827,PMID:12182165
MCOLN1	Q9GZU1	412	453	432	432	Mutagenesis	Note=Mediates localization to the plasma membrane and strong inwardly rectifying current. V->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18794901,ECO:0000269|PubMed:28112729;Dbxref=PMID:18794901,PMID:28112729
MCOLN1	Q9GZU1	412	453	411	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WJ9
MCOLN1	Q9GZU1	412	453	417	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WJ9
MCOLN1	Q9GZU1	412	453	448	450	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WJ9
HK3	P52790	357	434	1	923	Chain	ID=PRO_0000197590;Note=Hexokinase-3
HK3	P52790	357	434	27	471	Domain	Note=Hexokinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HK3	P52790	357	434	1	488	Region	Note=Regulatory
HK3	P52790	357	434	221	460	Region	Note=Hexokinase large subdomain 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HK3	P52790	357	434	420	420	Sequence conflict	Note=Q->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
HK3	P52790	357	434	431	431	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCMDC2	Q4G0Z9	75	95	1	681	Chain	ID=PRO_0000255258;Note=Minichromosome maintenance domain-containing protein 2
MCMDC2	Q4G0Z9	236	278	1	681	Chain	ID=PRO_0000255258;Note=Minichromosome maintenance domain-containing protein 2
MCMDC2	Q4G0Z9	75	95	1	242	Alternative sequence	ID=VSP_038998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCMDC2	Q4G0Z9	236	278	1	242	Alternative sequence	ID=VSP_038998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCMDC2	Q4G0Z9	75	95	64	75	Alternative sequence	ID=VSP_039000;Note=In isoform 4. HQPLKAAEVFQS->MIASTTMVRSAK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCMDC2	Q4G0Z9	75	95	94	94	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCMDC2	Q4G0Z9	236	278	258	258	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL17RE	Q8NFR9	49	89	24	667	Chain	ID=PRO_0000309467;Note=Interleukin-17 receptor E
IL17RE	Q8NFR9	222	245	24	667	Chain	ID=PRO_0000309467;Note=Interleukin-17 receptor E
IL17RE	Q8NFR9	49	89	24	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RE	Q8NFR9	222	245	24	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RE	Q8NFR9	49	89	1	116	Alternative sequence	ID=VSP_029190;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IL11RA	Q14626	317	357	23	422	Chain	ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha
IL11RA	Q14626	317	357	23	422	Chain	ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha
IL11RA	Q14626	317	357	23	422	Chain	ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha
IL11RA	Q14626	317	357	24	370	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL11RA	Q14626	317	357	24	370	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL11RA	Q14626	317	357	24	370	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL11RA	Q14626	317	357	220	317	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL11RA	Q14626	317	357	220	317	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL11RA	Q14626	317	357	220	317	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MED13L	Q71F56	2075	2129	1	2210	Chain	ID=PRO_0000076352;Note=Mediator of RNA polymerase II transcription subunit 13-like
MED13L	Q71F56	392	426	1	2210	Chain	ID=PRO_0000076352;Note=Mediator of RNA polymerase II transcription subunit 13-like
MED13L	Q71F56	132	159	1	2210	Chain	ID=PRO_0000076352;Note=Mediator of RNA polymerase II transcription subunit 13-like
MED13L	Q71F56	2075	2129	2083	2083	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:19369195,PMID:23186163
IGFBP5	P24593	189	229	21	272	Chain	ID=PRO_0000014385;Note=Insulin-like growth factor-binding protein 5
IGFBP5	P24593	189	229	189	263	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
IGFBP5	P24593	189	229	192	219	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00500,ECO:0000269|PubMed:22117064;Dbxref=PMID:22117064
HPGDS	O60760	44	75	1	199	Chain	ID=PRO_0000185934;Note=Hematopoietic prostaglandin D synthase
HPGDS	O60760	44	75	2	79	Domain	Note=GST N-terminal
HPGDS	O60760	44	75	49	51	Region	Note=Glutathione binding;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12627223,ECO:0000269|PubMed:15113825,ECO:0000269|PubMed:16547010,ECO:0000269|PubMed:18341273,ECO:0000269|PubMed:19939518;Dbxref=PMID:12627223,PMID:15113825,PMID:16547010,PMID:18341273,PMID:19939518
HPGDS	O60760	44	75	63	64	Region	Note=Glutathione binding;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12627223,ECO:0000269|PubMed:15113825,ECO:0000269|PubMed:16547010,ECO:0000269|PubMed:18341273,ECO:0000269|PubMed:19939518;Dbxref=PMID:12627223,PMID:15113825,PMID:16547010,PMID:18341273,PMID:19939518
HPGDS	O60760	44	75	46	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IYH
HPGDS	O60760	44	75	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CVD
HPGDS	O60760	44	75	59	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CVD
HPGDS	O60760	44	75	64	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CVD
HPR	P00739	64	89	1	348	Chain	ID=PRO_0000028486;Note=Haptoglobin-related protein
HPR	P00739	64	89	34	87	Domain	Note=Sushi
RNGTT	O60942	423	446	1	597	Chain	ID=PRO_0000210108;Note=mRNA-capping enzyme
RNGTT	O60942	423	446	229	597	Region	Note=GTase
RNGTT	O60942	423	446	424	446	Alternative sequence	ID=VSP_003202;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9512541;Dbxref=PMID:9512541
RNGTT	O60942	423	446	418	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S24
RNGTT	O60942	423	446	437	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S24
HUNK	P57058	419	435	1	714	Chain	ID=PRO_0000086004;Note=Hormonally up-regulated neu tumor-associated kinase
MCM3	P25205	609	656	2	808	Chain	ID=PRO_0000194093;Note=DNA replication licensing factor MCM3
MCM3	P25205	344	388	2	808	Chain	ID=PRO_0000194093;Note=DNA replication licensing factor MCM3
MCM3	P25205	344	388	295	502	Domain	Note=MCM
MCM3	P25205	344	388	345	352	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCM3	P25205	609	656	611	611	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ISG20L2	Q9H9L3	249	316	1	353	Chain	ID=PRO_0000084121;Note=Interferon-stimulated 20 kDa exonuclease-like 2
ISG20L2	Q9H9L3	249	316	1	353	Chain	ID=PRO_0000084121;Note=Interferon-stimulated 20 kDa exonuclease-like 2
ISG20L2	Q9H9L3	249	316	178	353	Domain	Note=Exonuclease
ISG20L2	Q9H9L3	249	316	178	353	Domain	Note=Exonuclease
MCTP1	Q6DN14	812	852	1	999	Chain	ID=PRO_0000294471;Note=Multiple C2 and transmembrane domain-containing protein 1
MCTP1	Q6DN14	747	772	1	999	Chain	ID=PRO_0000294471;Note=Multiple C2 and transmembrane domain-containing protein 1
MCTP1	Q6DN14	713	747	1	999	Chain	ID=PRO_0000294471;Note=Multiple C2 and transmembrane domain-containing protein 1
MCTP1	Q6DN14	424	450	1	999	Chain	ID=PRO_0000294471;Note=Multiple C2 and transmembrane domain-containing protein 1
MCTP1	Q6DN14	404	424	1	999	Chain	ID=PRO_0000294471;Note=Multiple C2 and transmembrane domain-containing protein 1
MCTP1	Q6DN14	391	404	1	999	Chain	ID=PRO_0000294471;Note=Multiple C2 and transmembrane domain-containing protein 1
MCTP1	Q6DN14	812	852	811	831	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCTP1	Q6DN14	424	450	1	484	Alternative sequence	ID=VSP_026655;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTP1	Q6DN14	404	424	1	484	Alternative sequence	ID=VSP_026655;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTP1	Q6DN14	391	404	1	484	Alternative sequence	ID=VSP_026655;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTP1	Q6DN14	424	450	405	450	Alternative sequence	ID=VSP_026658;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTP1	Q6DN14	404	424	405	450	Alternative sequence	ID=VSP_026658;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTP1	Q6DN14	812	852	813	852	Alternative sequence	ID=VSP_026659;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTP1	Q6DN14	812	852	813	821	Alternative sequence	ID=VSP_026660;Note=In isoform 4. LFLFVVWNF->ALYGTFINV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP1	Q6DN14	812	852	822	999	Alternative sequence	ID=VSP_026661;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP1	Q6DN14	713	747	727	727	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL12RB1	P42701	494	539	24	662	Chain	ID=PRO_0000010917;Note=Interleukin-12 receptor subunit beta-1
IL12RB1	P42701	396	442	24	662	Chain	ID=PRO_0000010917;Note=Interleukin-12 receptor subunit beta-1
IL12RB1	P42701	340	396	24	662	Chain	ID=PRO_0000010917;Note=Interleukin-12 receptor subunit beta-1
IL12RB1	P42701	494	539	24	662	Chain	ID=PRO_0000010917;Note=Interleukin-12 receptor subunit beta-1
IL12RB1	P42701	396	442	24	662	Chain	ID=PRO_0000010917;Note=Interleukin-12 receptor subunit beta-1
IL12RB1	P42701	340	396	24	662	Chain	ID=PRO_0000010917;Note=Interleukin-12 receptor subunit beta-1
IL12RB1	P42701	494	539	24	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	396	442	24	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	340	396	24	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	494	539	24	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	396	442	24	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	340	396	24	545	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	396	442	338	444	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB1	P42701	340	396	338	444	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB1	P42701	396	442	338	444	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB1	P42701	340	396	338	444	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB1	P42701	494	539	448	542	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB1	P42701	494	539	448	542	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB1	P42701	340	396	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	340	396	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	340	396	352	352	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	340	396	352	352	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	396	442	442	442	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	396	442	442	442	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB1	P42701	396	442	341	422	Alternative sequence	ID=VSP_037043;Note=In isoform 3. EPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASA->DGMISAHCNLRLPDSRDSPASASRVAGITGICHHTRLILYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	340	396	341	422	Alternative sequence	ID=VSP_037043;Note=In isoform 3. EPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASA->DGMISAHCNLRLPDSRDSPASASRVAGITGICHHTRLILYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	396	442	341	422	Alternative sequence	ID=VSP_037043;Note=In isoform 3. EPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASA->DGMISAHCNLRLPDSRDSPASASRVAGITGICHHTRLILYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	340	396	341	422	Alternative sequence	ID=VSP_037043;Note=In isoform 3. EPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASA->DGMISAHCNLRLPDSRDSPASASRVAGITGICHHTRLILYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	494	539	423	662	Alternative sequence	ID=VSP_037044;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	396	442	423	662	Alternative sequence	ID=VSP_037044;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	494	539	423	662	Alternative sequence	ID=VSP_037044;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	396	442	423	662	Alternative sequence	ID=VSP_037044;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IL12RB1	P42701	340	396	365	365	Natural variant	ID=VAR_011986;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs375947
IL12RB1	P42701	340	396	365	365	Natural variant	ID=VAR_011986;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs375947
IL12RB1	P42701	340	396	378	378	Natural variant	ID=VAR_011987;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs401502
IL12RB1	P42701	340	396	378	378	Natural variant	ID=VAR_011987;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs401502
IDO2	Q6ZQW0	78	118	1	420	Chain	ID=PRO_0000285262;Note=Indoleamine 2%2C3-dioxygenase 2
IFI27L2	Q9H2X8	12	66	1	130	Chain	ID=PRO_0000008740;Note=Interferon alpha-inducible protein 27-like protein 2
IFI27L2	Q9H2X8	2	12	1	130	Chain	ID=PRO_0000008740;Note=Interferon alpha-inducible protein 27-like protein 2
IFI27L2	Q9H2X8	12	66	8	28	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI27L2	Q9H2X8	2	12	8	28	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI27L2	Q9H2X8	12	66	43	63	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI27L2	Q9H2X8	12	66	66	86	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
INPP5A	Q14642	363	386	1	409	Chain	ID=PRO_0000209719;Note=Type I inositol 1%2C4%2C5-trisphosphate 5-phosphatase
MCU	Q8NE86	73	130	51	351	Chain	ID=PRO_0000282976;Note=Calcium uniporter protein%2C mitochondrial
MCU	Q8NE86	219	287	51	351	Chain	ID=PRO_0000282976;Note=Calcium uniporter protein%2C mitochondrial
MCU	Q8NE86	73	130	51	233	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27099988;Dbxref=PMID:27099988
MCU	Q8NE86	219	287	51	233	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27099988;Dbxref=PMID:27099988
MCU	Q8NE86	219	287	234	256	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCU	Q8NE86	219	287	257	265	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27099988;Dbxref=PMID:27099988
MCU	Q8NE86	219	287	266	283	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCU	Q8NE86	219	287	284	351	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23755363,ECO:0000305|PubMed:27099988;Dbxref=PMID:23755363,PMID:27099988
MCU	Q8NE86	73	130	75	165	Region	Note=N-terminal MCU domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26341627;Dbxref=PMID:26341627
MCU	Q8NE86	219	287	216	234	Region	Note=Outer juxtamembrane helix (OJMH);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q21121
MCU	Q8NE86	219	287	283	292	Region	Note=Inner juxtamembrane helix (IJMH);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q21121
MCU	Q8NE86	219	287	192	223	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MCU	Q8NE86	219	287	261	264	Motif	Note=DXXE;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q21121
MCU	Q8NE86	73	130	92	92	Modified residue	Note=Phosphoserine%3B by CaMK2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23051746;Dbxref=PMID:23051746
MCU	Q8NE86	219	287	166	219	Alternative sequence	ID=VSP_024263;Note=In isoform 2. DLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEK->VEMGFCHVGQNGFELLTSSYLPASASQSAEIIA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCU	Q8NE86	73	130	92	92	Mutagenesis	Note=Decreased MCU current%3B when associated with A-57. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23051746;Dbxref=PMID:23051746
MCU	Q8NE86	73	130	92	92	Mutagenesis	Note=Impairs Ca(2+) uptake%2C but has no effect on oligomerization and interaction with MCU1 and MCU2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26341627;Dbxref=PMID:26341627
MCU	Q8NE86	219	287	257	257	Mutagenesis	Note=According to a report%2C inhibits calcium uptake. According to a subsequent report%2C does not affect greatly calcium uptake. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685886,ECO:0000269|PubMed:27135929;Dbxref=PMID:21685886,PMID:27135929
MCU	Q8NE86	219	287	257	257	Mutagenesis	Note=Does not affect greatly calcium uptake. E->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27135929;Dbxref=PMID:27135929
MCU	Q8NE86	219	287	259	259	Mutagenesis	Note=Does not inhibit calcium uptake. Strongly reduced sensitivity to ruthenium red inhibition. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685886,ECO:0000269|PubMed:23755363;Dbxref=PMID:21685886,PMID:23755363
MCU	Q8NE86	219	287	259	259	Mutagenesis	Note=Prevents entrance of calcium into the pore. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27135929;Dbxref=PMID:27135929
MCU	Q8NE86	219	287	261	264	Mutagenesis	Note=Dominant negative (DN) mutant%3B inhibits calcium uptake. Inhibits calcium channel activity. Expression of the dominant negative protein in mice%2C leads to mice that are incapable of physiological fight or flight heart rate acceleration. DIME->AIMA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685886,ECO:0000269|PubMed:21685888,ECO:0000269|PubMed:25603276;Dbxref=PMID:21685886,PMID:21685888,PMID:25603276
MCU	Q8NE86	219	287	261	261	Mutagenesis	Note=Partially functional%3B does not completely abolish calcium channel activity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27135929;Dbxref=PMID:27135929
MCU	Q8NE86	219	287	264	264	Mutagenesis	Note=Abolishes calcium channel activity. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27135929;Dbxref=PMID:27135929
MCU	Q8NE86	73	130	107	107	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCU	Q8NE86	73	130	76	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XTB
MCU	Q8NE86	73	130	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XTB
MCU	Q8NE86	73	130	91	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUI
MCU	Q8NE86	73	130	97	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XTB
MCU	Q8NE86	73	130	103	105	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XTB
MCU	Q8NE86	73	130	108	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XTB
MCU	Q8NE86	73	130	125	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XTB
MED12L	Q86YW9	279	369	1	2145	Chain	ID=PRO_0000313053;Note=Mediator of RNA polymerase II transcription subunit 12-like protein
MED12L	Q86YW9	656	715	1	2145	Chain	ID=PRO_0000313053;Note=Mediator of RNA polymerase II transcription subunit 12-like protein
MED12L	Q86YW9	1905	1935	1	2145	Chain	ID=PRO_0000313053;Note=Mediator of RNA polymerase II transcription subunit 12-like protein
MED12L	Q86YW9	1905	1935	1877	2134	Compositional bias	Note=Gln-rich
MED12L	Q86YW9	656	715	656	656	Alternative sequence	ID=VSP_029994;Note=In isoform 3. E->EEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11524702;Dbxref=PMID:11524702
MED12L	Q86YW9	1905	1935	722	2145	Alternative sequence	ID=VSP_029996;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11524702;Dbxref=PMID:11524702
MAD2L2	Q9UI95	53	77	1	211	Chain	ID=PRO_0000126119;Note=Mitotic spindle assembly checkpoint protein MAD2B
MAD2L2	Q9UI95	53	77	1	211	Chain	ID=PRO_0000126119;Note=Mitotic spindle assembly checkpoint protein MAD2B
MAD2L2	Q9UI95	53	77	1	211	Chain	ID=PRO_0000126119;Note=Mitotic spindle assembly checkpoint protein MAD2B
MAD2L2	Q9UI95	53	77	13	203	Domain	Note=HORMA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00109
MAD2L2	Q9UI95	53	77	13	203	Domain	Note=HORMA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00109
MAD2L2	Q9UI95	53	77	13	203	Domain	Note=HORMA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00109
MAD2L2	Q9UI95	53	77	21	155	Region	Note=Mediates interaction with REV1 and REV3L and homodimerization
MAD2L2	Q9UI95	53	77	21	155	Region	Note=Mediates interaction with REV1 and REV3L and homodimerization
MAD2L2	Q9UI95	53	77	21	155	Region	Note=Mediates interaction with REV1 and REV3L and homodimerization
MAD2L2	Q9UI95	53	77	63	63	Mutagenesis	Note=Alters interaction with REV3L. Loss of interaction with REV3L%3B when associated with A-171. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164194;Dbxref=PMID:20164194
MAD2L2	Q9UI95	53	77	63	63	Mutagenesis	Note=Alters interaction with REV3L. Loss of interaction with REV3L%3B when associated with A-171. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164194;Dbxref=PMID:20164194
MAD2L2	Q9UI95	53	77	63	63	Mutagenesis	Note=Alters interaction with REV3L. Loss of interaction with REV3L%3B when associated with A-171. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164194;Dbxref=PMID:20164194
MAD2L2	Q9UI95	53	77	50	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ABD
MAD2L2	Q9UI95	53	77	50	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ABD
MAD2L2	Q9UI95	53	77	50	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ABD
MAD2L2	Q9UI95	53	77	58	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ABD
MAD2L2	Q9UI95	53	77	58	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ABD
MAD2L2	Q9UI95	53	77	58	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ABD
CLNS1A	P54105	157	215	2	237	Chain	ID=PRO_0000185155;Note=Methylosome subunit pICln
CLNS1A	P54105	87	121	2	237	Chain	ID=PRO_0000185155;Note=Methylosome subunit pICln
CLNS1A	P54105	157	215	2	237	Chain	ID=PRO_0000185155;Note=Methylosome subunit pICln
CLNS1A	P54105	87	121	2	237	Chain	ID=PRO_0000185155;Note=Methylosome subunit pICln
CLNS1A	P54105	87	121	102	102	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.10,ECO:0000269|Ref.11;Dbxref=PMID:17081983,PMID:17487921,PMID:18318008,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
CLNS1A	P54105	87	121	102	102	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.10,ECO:0000269|Ref.11;Dbxref=PMID:17081983,PMID:17487921,PMID:18318008,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
CLNS1A	P54105	157	215	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	195	195	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	195	195	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	198	198	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	198	198	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLNS1A	P54105	157	215	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
IFT172	Q9UG01	1605	1638	1	1749	Chain	ID=PRO_0000328941;Note=Intraflagellar transport protein 172 homolog
IFT172	Q9UG01	1437	1476	1	1749	Chain	ID=PRO_0000328941;Note=Intraflagellar transport protein 172 homolog
IFT172	Q9UG01	610	645	1	1749	Chain	ID=PRO_0000328941;Note=Intraflagellar transport protein 172 homolog
IFT172	Q9UG01	508	564	1	1749	Chain	ID=PRO_0000328941;Note=Intraflagellar transport protein 172 homolog
IFT172	Q9UG01	389	407	1	1749	Chain	ID=PRO_0000328941;Note=Intraflagellar transport protein 172 homolog
IFT172	Q9UG01	508	564	483	520	Repeat	Note=WD 8
IFT172	Q9UG01	508	564	521	559	Repeat	Note=WD 9
IFT172	Q9UG01	610	645	593	624	Repeat	Note=TPR 1
IFT172	Q9UG01	1437	1476	1411	1445	Repeat	Note=TPR 12
IFT172	Q9UG01	1437	1476	1447	1477	Repeat	Note=TPR 13
IFT172	Q9UG01	1605	1638	1574	1607	Repeat	Note=TPR 14
IFT172	Q9UG01	508	564	509	532	Alternative sequence	ID=VSP_054428;Note=In isoform 3. LHLYDIESCSKTMILNFCSYMQWV->VRRATKALGIGWPTEGVRQAATRD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT172	Q9UG01	1605	1638	533	1749	Alternative sequence	ID=VSP_054429;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT172	Q9UG01	1437	1476	533	1749	Alternative sequence	ID=VSP_054429;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT172	Q9UG01	610	645	533	1749	Alternative sequence	ID=VSP_054429;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT172	Q9UG01	508	564	533	1749	Alternative sequence	ID=VSP_054429;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT172	Q9UG01	1605	1638	1526	1749	Alternative sequence	ID=VSP_032849;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
IFT172	Q9UG01	1605	1638	1605	1605	Natural variant	ID=VAR_073802;Note=In RP71%3B hypomorphic mutation. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25168386;Dbxref=dbSNP:rs786205856,PMID:25168386
IFT172	Q9UG01	1437	1476	1475	1475	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF1AY	O14602	117	134	1	144	Chain	ID=PRO_0000145102;Note=Eukaryotic translation initiation factor 1A%2C Y-chromosomal
MYBBP1A	Q9BQG0	1006	1029	1	1328	Chain	ID=PRO_0000096255;Note=Myb-binding protein 1A
MYBBP1A	Q9BQG0	691	720	1	1328	Chain	ID=PRO_0000096255;Note=Myb-binding protein 1A
MYBBP1A	Q9BQG0	440	476	1	1328	Chain	ID=PRO_0000096255;Note=Myb-binding protein 1A
MYBBP1A	Q9BQG0	440	476	1	582	Region	Note=Interaction with MYB;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TPV4
MYBBP1A	Q9BQG0	691	720	720	784	Compositional bias	Note=Glu-rich
MYBBP1A	Q9BQG0	1006	1029	1028	1028	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HTRA2	O43464	237	302	134	458	Chain	ID=PRO_0000026946;Note=Serine protease HTRA2%2C mitochondrial
HTRA2	O43464	302	313	134	458	Chain	ID=PRO_0000026946;Note=Serine protease HTRA2%2C mitochondrial
HTRA2	O43464	372	403	134	458	Chain	ID=PRO_0000026946;Note=Serine protease HTRA2%2C mitochondrial
HTRA2	O43464	372	403	364	445	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
HTRA2	O43464	237	302	166	342	Region	Note=Serine protease
HTRA2	O43464	302	313	166	342	Region	Note=Serine protease
HTRA2	O43464	302	313	306	306	Active site	Note=Charge relay system;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11967569;Dbxref=PMID:11967569
HTRA2	O43464	237	302	238	302	Alternative sequence	ID=VSP_005359;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10995577;Dbxref=PMID:10995577
HTRA2	O43464	302	313	238	302	Alternative sequence	ID=VSP_005359;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10995577;Dbxref=PMID:10995577
HTRA2	O43464	302	313	313	313	Alternative sequence	ID=VSP_005360;Note=In isoform 3. L->LARELGAVSLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10971580;Dbxref=PMID:10971580
HTRA2	O43464	372	403	314	458	Alternative sequence	ID=VSP_005362;Note=In isoform 4. DGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE->VSETSFLPRIPAPGQCGKGRFPLIQGCLVKFLSSSLLAISQYPTRSPQHLLVLLFGCPHPLLFV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10971580;Dbxref=PMID:10971580
HTRA2	O43464	372	403	372	403	Alternative sequence	ID=VSP_005361;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10971580,ECO:0000303|PubMed:10995577;Dbxref=PMID:10971580,PMID:10995577
HTRA2	O43464	237	302	243	244	Natural variant	ID=VAR_077960;Note=In MGCA8%3B loss of protein expression. LP->PS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27696117;Dbxref=dbSNP:rs1057519082,PMID:27696117
HTRA2	O43464	372	403	399	399	Natural variant	ID=VAR_027350;Note=Polymorphism%3B may be a risk factor for Parkinson disease%3B reduced protease activity. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15961413,ECO:0000269|PubMed:18364387,ECO:0000269|PubMed:25422467,ECO:0000269|PubMed:27535533;Dbxref=dbSNP:rs72470545,PMID:15961413,PMID:18364387,PMID:25422467,PMID:27535533
HTRA2	O43464	302	313	306	306	Mutagenesis	Note=Loss of protease activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10644717;Dbxref=PMID:10644717
HTRA2	O43464	237	302	248	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	237	302	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	237	302	265	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHT
HTRA2	O43464	237	302	271	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	237	302	295	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	302	313	303	307	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	302	313	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	372	403	371	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	372	403	391	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA2	O43464	372	403	401	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3N
HTRA1	Q92743	393	424	23	480	Chain	ID=PRO_0000026943;Note=Serine protease HTRA1
HTRA1	Q92743	393	424	365	467	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
HTRA1	Q92743	393	424	392	401	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JOA
HTRA1	Q92743	393	424	411	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JOA
HTRA1	Q92743	393	424	419	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JOA
HTRA1	Q92743	393	424	422	426	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JOA
HVCN1	Q96D96	102	137	1	273	Chain	ID=PRO_0000342187;Note=Voltage-gated hydrogen channel 1
HVCN1	Q96D96	7	102	1	273	Chain	ID=PRO_0000342187;Note=Voltage-gated hydrogen channel 1
HVCN1	Q96D96	102	137	1	273	Chain	ID=PRO_0000342187;Note=Voltage-gated hydrogen channel 1
HVCN1	Q96D96	7	102	1	273	Chain	ID=PRO_0000342187;Note=Voltage-gated hydrogen channel 1
HVCN1	Q96D96	7	102	1	100	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	7	102	1	100	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	102	137	101	121	Transmembrane	Note=Helical%3B Name%3DSegment S1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	7	102	101	121	Transmembrane	Note=Helical%3B Name%3DSegment S1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	102	137	101	121	Transmembrane	Note=Helical%3B Name%3DSegment S1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	7	102	101	121	Transmembrane	Note=Helical%3B Name%3DSegment S1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	102	137	122	138	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	102	137	122	138	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
HVCN1	Q96D96	7	102	46	55	Compositional bias	Note=Poly-Glu
HVCN1	Q96D96	7	102	46	55	Compositional bias	Note=Poly-Glu
HVCN1	Q96D96	7	102	29	29	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	29	29	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	97	97	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	97	97	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	1	20	Alternative sequence	ID=VSP_045052;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HVCN1	Q96D96	7	102	1	20	Alternative sequence	ID=VSP_045052;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HVCN1	Q96D96	102	137	66	102	Alternative sequence	ID=VSP_034395;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HVCN1	Q96D96	7	102	66	102	Alternative sequence	ID=VSP_034395;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HVCN1	Q96D96	102	137	66	102	Alternative sequence	ID=VSP_034395;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HVCN1	Q96D96	7	102	66	102	Alternative sequence	ID=VSP_034395;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HVCN1	Q96D96	7	102	29	29	Mutagenesis	Note=Loss of a phosphorylation site. Reduces phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	29	29	Mutagenesis	Note=Loss of a phosphorylation site. Reduces phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	97	97	Mutagenesis	Note=Loss of a phosphorylation site. Strongly reduces phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	7	102	97	97	Mutagenesis	Note=Loss of a phosphorylation site. Strongly reduces phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20037153;Dbxref=PMID:20037153
HVCN1	Q96D96	102	137	112	112	Mutagenesis	Note=Alters channel selectivity. Converts the proton channel to an anion channel. D->A%2CF%2CN%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22020278;Dbxref=PMID:22020278
HVCN1	Q96D96	102	137	112	112	Mutagenesis	Note=Alters channel selectivity. Converts the proton channel to an anion channel. D->A%2CF%2CN%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22020278;Dbxref=PMID:22020278
HVCN1	Q96D96	102	137	112	112	Mutagenesis	Note=No effect on channel activity and proton selectivity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22020278;Dbxref=PMID:22020278
HVCN1	Q96D96	102	137	112	112	Mutagenesis	Note=No effect on channel activity and proton selectivity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22020278;Dbxref=PMID:22020278
HVCN1	Q96D96	102	137	112	112	Mutagenesis	Note=Abolishes channel activity. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22020278;Dbxref=PMID:22020278
HVCN1	Q96D96	102	137	112	112	Mutagenesis	Note=Abolishes channel activity. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22020278;Dbxref=PMID:22020278
MCM7	P33993	532	559	2	719	Chain	ID=PRO_0000194119;Note=DNA replication licensing factor MCM7
MCM7	P33993	372	400	2	719	Chain	ID=PRO_0000194119;Note=DNA replication licensing factor MCM7
MCM7	P33993	240	290	2	719	Chain	ID=PRO_0000194119;Note=DNA replication licensing factor MCM7
MCM7	P33993	37	92	2	719	Chain	ID=PRO_0000194119;Note=DNA replication licensing factor MCM7
MCM7	P33993	532	559	332	538	Domain	Note=MCM
MCM7	P33993	372	400	332	538	Domain	Note=MCM
MCM7	P33993	372	400	381	388	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCM7	P33993	532	559	521	564	Region	Note=Interaction with RAD17;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15538388;Dbxref=PMID:15538388
MCM7	P33993	37	92	1	176	Alternative sequence	ID=VSP_044310;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCM7	P33993	532	559	329	658	Alternative sequence	ID=VSP_003205;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCM7	P33993	372	400	329	658	Alternative sequence	ID=VSP_003205;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HYAL4	Q2M3T9	318	348	1	481	Chain	ID=PRO_0000301999;Note=Hyaluronidase-4
HYAL4	Q2M3T9	318	348	1	481	Chain	ID=PRO_0000301999;Note=Hyaluronidase-4
HYAL4	Q2M3T9	318	348	30	453	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HYAL4	Q2M3T9	318	348	30	453	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HYAL4	Q2M3T9	318	348	343	343	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HYAL4	Q2M3T9	318	348	343	343	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HYAL4	Q2M3T9	318	348	59	351	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HYAL4	Q2M3T9	318	348	59	351	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HYAL4	Q2M3T9	318	348	346	346	Natural variant	ID=VAR_034936;Note=A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6949082,PMID:15489334
HYAL4	Q2M3T9	318	348	346	346	Natural variant	ID=VAR_034936;Note=A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6949082,PMID:15489334
MCMBP	Q9BTE3	516	571	1	642	Chain	ID=PRO_0000089827;Note=Mini-chromosome maintenance complex-binding protein
MCMBP	Q9BTE3	95	109	1	642	Chain	ID=PRO_0000089827;Note=Mini-chromosome maintenance complex-binding protein
MCMBP	Q9BTE3	95	109	1	173	Alternative sequence	ID=VSP_040721;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMGN3	Q15651	49	87	1	99	Chain	ID=PRO_0000232574;Note=High mobility group nucleosome-binding domain-containing protein 3
HMGN3	Q15651	22	32	1	99	Chain	ID=PRO_0000232574;Note=High mobility group nucleosome-binding domain-containing protein 3
HMGN3	Q15651	49	87	78	78	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
HMGN3	Q15651	49	87	76	77	Alternative sequence	ID=VSP_017907;Note=In isoform 2. AP->EN;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12033773,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:12033773,PMID:14702039,PMID:15489334
HMGN3	Q15651	49	87	78	99	Alternative sequence	ID=VSP_017908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12033773,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:12033773,PMID:14702039,PMID:15489334
HPS1	Q92902	329	385	1	700	Chain	ID=PRO_0000084047;Note=Hermansky-Pudlak syndrome 1 protein
HPS1	Q92902	256	289	1	700	Chain	ID=PRO_0000084047;Note=Hermansky-Pudlak syndrome 1 protein
HPS1	Q92902	0	39	1	700	Chain	ID=PRO_0000084047;Note=Hermansky-Pudlak syndrome 1 protein
HPS1	Q92902	329	385	1	700	Chain	ID=PRO_0000084047;Note=Hermansky-Pudlak syndrome 1 protein
HPS1	Q92902	256	289	1	700	Chain	ID=PRO_0000084047;Note=Hermansky-Pudlak syndrome 1 protein
HPS1	Q92902	0	39	1	700	Chain	ID=PRO_0000084047;Note=Hermansky-Pudlak syndrome 1 protein
HPS1	Q92902	0	39	34	39	Compositional bias	Note=Poly-Glu
HPS1	Q92902	0	39	34	39	Compositional bias	Note=Poly-Glu
HPS1	Q92902	256	289	257	289	Alternative sequence	ID=VSP_004289;Note=In isoform II. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HPS1	Q92902	256	289	257	289	Alternative sequence	ID=VSP_004289;Note=In isoform II. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HPS1	Q92902	329	385	325	700	Alternative sequence	ID=VSP_004291;Note=In isoform III. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9579545;Dbxref=PMID:15489334,PMID:9579545
HPS1	Q92902	329	385	325	700	Alternative sequence	ID=VSP_004291;Note=In isoform III. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9579545;Dbxref=PMID:15489334,PMID:9579545
HPS1	Q92902	256	289	283	283	Natural variant	ID=VAR_005290;Note=G->W;Dbxref=dbSNP:rs11592273
HPS1	Q92902	256	289	283	283	Natural variant	ID=VAR_005290;Note=G->W;Dbxref=dbSNP:rs11592273
HEATR5B	Q9P2D3	1772	1848	1	2071	Chain	ID=PRO_0000311994;Note=HEAT repeat-containing protein 5B
HEATR5B	Q9P2D3	1683	1772	1	2071	Chain	ID=PRO_0000311994;Note=HEAT repeat-containing protein 5B
HEATR5B	Q9P2D3	1507	1592	1	2071	Chain	ID=PRO_0000311994;Note=HEAT repeat-containing protein 5B
HEATR5B	Q9P2D3	1368	1428	1	2071	Chain	ID=PRO_0000311994;Note=HEAT repeat-containing protein 5B
HEATR5B	Q9P2D3	1507	1592	1563	1563	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HEATR5B	Q9P2D3	1507	1592	1564	1564	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HEATR5B	Q9P2D3	1683	1772	1737	1737	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
HEATR5B	Q9P2D3	1772	1848	769	2071	Alternative sequence	ID=VSP_029691;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HEATR5B	Q9P2D3	1683	1772	769	2071	Alternative sequence	ID=VSP_029691;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HEATR5B	Q9P2D3	1507	1592	769	2071	Alternative sequence	ID=VSP_029691;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HEATR5B	Q9P2D3	1368	1428	769	2071	Alternative sequence	ID=VSP_029691;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HEATR5B	Q9P2D3	1772	1848	1684	1773	Alternative sequence	ID=VSP_029692;Note=In isoform 3. NEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HEATR5B	Q9P2D3	1683	1772	1684	1773	Alternative sequence	ID=VSP_029692;Note=In isoform 3. NEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HTATSF1	O43719	122	138	2	755	Chain	ID=PRO_0000248604;Note=HIV Tat-specific factor 1
HTATSF1	O43719	122	138	2	755	Chain	ID=PRO_0000248604;Note=HIV Tat-specific factor 1
HTATSF1	O43719	122	138	133	218	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HTATSF1	O43719	122	138	133	218	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HTATSF1	O43719	122	138	136	136	Mutagenesis	Note=Loss of interaction with U snRNPs. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11780068;Dbxref=PMID:11780068
HTATSF1	O43719	122	138	136	136	Mutagenesis	Note=Loss of interaction with U snRNPs. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11780068;Dbxref=PMID:11780068
HTATSF1	O43719	122	138	125	125	Sequence conflict	Note=F->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
HTATSF1	O43719	122	138	125	125	Sequence conflict	Note=F->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCOLN2	Q8IZK6	445	514	1	566	Chain	ID=PRO_0000215365;Note=Mucolipin-2
MCOLN2	Q8IZK6	445	514	441	448	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6RG56
MCOLN2	Q8IZK6	445	514	449	469	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6RG56
MCOLN2	Q8IZK6	445	514	470	480	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6RG56
MCOLN2	Q8IZK6	445	514	481	502	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6RG56
MCOLN2	Q8IZK6	445	514	503	566	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6RG56
MCOLN2	Q8IZK6	445	514	461	464	Motif	Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6RG56
MCOLN2	Q8IZK6	445	514	457	457	Mutagenesis	Note=Does not effect current amplitude%3B possible effect on regulation. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19940139;Dbxref=PMID:19940139
MCOLN2	Q8IZK6	445	514	463	464	Mutagenesis	Note=Blocks channel activity. Decreases recycling of internalized CD59 to the cell surface. DD->KK;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17662026,ECO:0000269|PubMed:19940139;Dbxref=PMID:17662026,PMID:19940139
MCM6	Q14566	684	736	1	821	Chain	ID=PRO_0000194113;Note=DNA replication licensing factor MCM6
MCM6	Q14566	585	639	1	821	Chain	ID=PRO_0000194113;Note=DNA replication licensing factor MCM6
MCM6	Q14566	490	542	1	821	Chain	ID=PRO_0000194113;Note=DNA replication licensing factor MCM6
MCM6	Q14566	85	121	1	821	Chain	ID=PRO_0000194113;Note=DNA replication licensing factor MCM6
MCM6	Q14566	490	542	346	553	Domain	Note=MCM
MCM6	Q14566	490	542	528	531	Motif	Note=Arginine finger
MCM6	Q14566	684	736	689	689	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97311
MCM6	Q14566	490	542	495	495	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM6	Q14566	684	736	709	711	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LE8
MCM6	Q14566	684	736	714	716	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LE8
MCM6	Q14566	684	736	718	737	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLQ
HYAL3	O43820	298	328	21	417	Chain	ID=PRO_0000248200;Note=Hyaluronidase-3
HYAL3	O43820	298	328	42	331	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q12794
HYAL3	O43820	298	328	299	328	Alternative sequence	ID=VSP_020194;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12084718;Dbxref=PMID:12084718
IL22RA2	Q969J5	66	97	22	263	Chain	ID=PRO_0000011016;Note=Interleukin-22 receptor subunit alpha-2
IL22RA2	Q969J5	66	97	26	68	Domain	Note=Fibronectin type-III 1
IL22RA2	Q969J5	66	97	67	98	Alternative sequence	ID=VSP_013105;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11390453,ECO:0000303|PubMed:11390454,ECO:0000303|PubMed:11481447,ECO:0000303|PubMed:11607789,ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:11390453,PMID:11390454,PMID:11481447,PMID:11607789,PMID:12975309,PMID:15489334
IL22RA2	Q969J5	66	97	59	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G9V
MCUR1	Q96AQ8	285	303	1	359	Chain	ID=PRO_0000295692;Note=Mitochondrial calcium uniporter regulator 1
MCUR1	Q96AQ8	261	285	1	359	Chain	ID=PRO_0000295692;Note=Mitochondrial calcium uniporter regulator 1
MCUR1	Q96AQ8	213	247	1	359	Chain	ID=PRO_0000295692;Note=Mitochondrial calcium uniporter regulator 1
MCUR1	Q96AQ8	285	303	86	338	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23178883;Dbxref=PMID:23178883
MCUR1	Q96AQ8	261	285	86	338	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23178883;Dbxref=PMID:23178883
MCUR1	Q96AQ8	213	247	86	338	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23178883;Dbxref=PMID:23178883
MCUR1	Q96AQ8	285	303	235	310	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MCUR1	Q96AQ8	261	285	235	310	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MCUR1	Q96AQ8	213	247	235	310	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MCUR1	Q96AQ8	213	247	179	257	Alternative sequence	ID=VSP_026998;Note=In isoform 2. GFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLK->ESHSFIQAGVQWHSLGLLQPPPPGFKRSSHLILLSSWDYRHAPPHLDNFSVFLLETGFHHVGQAGLKLLTSSDPPTLAS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCUR1	Q96AQ8	285	303	258	359	Alternative sequence	ID=VSP_026999;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCUR1	Q96AQ8	261	285	258	359	Alternative sequence	ID=VSP_026999;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCUR1	Q96AQ8	213	247	216	216	Natural variant	ID=VAR_033321;Note=T->A;Dbxref=dbSNP:rs3180196
ICA1L	Q8NDH6	414	444	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	328	414	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	303	328	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	186	228	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	414	444	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	328	414	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	303	328	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	186	228	1	482	Chain	ID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
ICA1L	Q8NDH6	186	228	44	247	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1L	Q8NDH6	186	228	44	247	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1L	Q8NDH6	414	444	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	328	414	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	303	328	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	186	228	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	414	444	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	328	414	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	303	328	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	186	228	188	482	Alternative sequence	ID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1L	Q8NDH6	328	414	334	334	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICA1L	Q8NDH6	328	414	334	334	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGFBP7	Q16270	195	234	27	282	Chain	ID=PRO_0000014392;Note=Insulin-like growth factor-binding protein 7
IGFBP7	Q16270	195	234	160	264	Domain	Note=Ig-like C2-type
IGFBP7	Q16270	195	234	181	248	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
ICAM3	P32942	25	114	1	29	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM3	P32942	216	312	30	547	Chain	ID=PRO_0000014794;Note=Intercellular adhesion molecule 3
ICAM3	P32942	25	114	30	547	Chain	ID=PRO_0000014794;Note=Intercellular adhesion molecule 3
ICAM3	P32942	216	312	30	485	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM3	P32942	25	114	30	485	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM3	P32942	25	114	46	103	Domain	Note=Ig-like C2-type 1
ICAM3	P32942	216	312	234	301	Domain	Note=Ig-like C2-type 3
ICAM3	P32942	25	114	52	52	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15728350;Dbxref=PMID:15728350
ICAM3	P32942	25	114	84	84	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
ICAM3	P32942	25	114	87	87	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
ICAM3	P32942	25	114	101	101	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM3	P32942	25	114	110	110	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15728350;Dbxref=PMID:15728350
ICAM3	P32942	216	312	264	264	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM3	P32942	216	312	295	295	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
ICAM3	P32942	216	312	308	308	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM3	P32942	25	114	53	96	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:1T0P,ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:15728350;Dbxref=PMID:15728350
ICAM3	P32942	25	114	57	100	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1T0P,ECO:0000269|PubMed:15728350;Dbxref=PMID:15728350
ICAM3	P32942	216	312	241	294	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
ICAM3	P32942	25	114	63	63	Natural variant	ID=VAR_046547;Note=I->V;Dbxref=dbSNP:rs17697947
ICAM3	P32942	25	114	60	60	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM3	P32942	25	114	34	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
ICAM3	P32942	25	114	48	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
ICAM3	P32942	25	114	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
ICAM3	P32942	25	114	68	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
ICAM3	P32942	25	114	80	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
ICAM3	P32942	25	114	92	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
ICAM3	P32942	25	114	103	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T0P
HSPA12A	O43301	278	307	2	675	Chain	ID=PRO_0000078292;Note=Heat shock 70 kDa protein 12A
HSCB	Q8IWL3	111	141	30	235	Chain	ID=PRO_0000007262;Note=Iron-sulfur cluster co-chaperone protein HscB%2C mitochondrial
HSCB	Q8IWL3	189	205	30	235	Chain	ID=PRO_0000007262;Note=Iron-sulfur cluster co-chaperone protein HscB%2C mitochondrial
HSCB	Q8IWL3	111	141	72	144	Domain	Note=J
HSCB	Q8IWL3	111	141	111	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BVO
HSCB	Q8IWL3	111	141	134	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BVO
HSCB	Q8IWL3	189	205	178	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BVO
MCOLN3	Q8TDD5	440	509	1	553	Chain	ID=PRO_0000215367;Note=Mucolipin-3
MCOLN3	Q8TDD5	315	365	1	553	Chain	ID=PRO_0000215367;Note=Mucolipin-3
MCOLN3	Q8TDD5	76	132	1	553	Chain	ID=PRO_0000215367;Note=Mucolipin-3
MCOLN3	Q8TDD5	76	132	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	76	132	84	283	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	315	365	305	341	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	315	365	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	315	365	363	371	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	440	509	436	443	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	440	509	444	464	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	440	509	465	475	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	440	509	476	497	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	440	509	498	553	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	76	132	104	118	Region	Note=Extracellular/lumenal pore loop;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9GZU1
MCOLN3	Q8TDD5	440	509	456	459	Motif	Note=Selectivity filter;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	76	132	77	132	Alternative sequence	ID=VSP_010823;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCOLN3	Q8TDD5	76	132	108	108	Mutagenesis	Note=Abolishes basal channel activity without affecting channel activation by a synthetic agonist%3B when associated with N-111 and N-112. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	76	132	111	111	Mutagenesis	Note=Abolishes basal channel activity without affecting channel activation by a synthetic agonist%3B when associated with N-108 and N-112. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	76	132	112	112	Mutagenesis	Note=Abolishes basal channel activity without affecting channel activation by a synthetic agonist%3B when associated with N-108 and N-111. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
MCOLN3	Q8TDD5	440	509	449	449	Mutagenesis	Note=Constitutive active channel%3B greatly impairs inhibition by lumenal Na(+). E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20378547;Dbxref=PMID:20378547
MCOLN3	Q8TDD5	440	509	449	449	Mutagenesis	Note=Abolishes channel activity. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20378547;Dbxref=PMID:20378547
MCOLN3	Q8TDD5	440	509	458	459	Mutagenesis	Note=Enhances endocytosis. DD->KK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19522758;Dbxref=PMID:19522758
MCOLN3	Q8TDD5	440	509	458	458	Mutagenesis	Note=Nearly abolishes channel activity%3B inhibits starvation-induced autophagy. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19522758;Dbxref=PMID:19522758
MCOLN3	Q8TDD5	440	509	459	459	Mutagenesis	Note=Decreases in Ca(2+) permeability and selectivity%3B decreases channel pore dynamic behavior. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20378547;Dbxref=PMID:20378547
MCOLN3	Q8TDD5	440	509	497	497	Mutagenesis	Note=Nearly abolishes channel activation by a synthetic agonist. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29106414;Dbxref=PMID:29106414
HK2	P52789	165	197	1	917	Chain	ID=PRO_0000197587;Note=Hexokinase-2
HK2	P52789	165	197	16	458	Domain	Note=Hexokinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HK2	P52789	165	197	13	475	Region	Note=Regulatory
HK2	P52789	165	197	73	207	Region	Note=Hexokinase small subdomain 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01084
HK2	P52789	165	197	172	173	Region	Note=Substrate 1 binding
HK2	P52789	165	197	165	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HFU
HK2	P52789	165	197	185	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZT
IL17RD	Q8NFM7	289	326	17	739	Chain	ID=PRO_0000041871;Note=Interleukin-17 receptor D
IL17RD	Q8NFM7	61	103	17	739	Chain	ID=PRO_0000041871;Note=Interleukin-17 receptor D
IL17RD	Q8NFM7	289	326	17	299	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RD	Q8NFM7	61	103	17	299	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RD	Q8NFM7	289	326	300	320	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RD	Q8NFM7	289	326	321	739	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RD	Q8NFM7	61	103	62	62	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RD	Q8NFM7	61	103	80	80	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RD	Q8NFM7	61	103	1	144	Alternative sequence	ID=VSP_015582;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12958313,ECO:0000303|PubMed:17974005;Dbxref=PMID:12958313,PMID:17974005
IL17RD	Q8NFM7	289	326	301	301	Natural variant	ID=VAR_023479;Note=V->M;Dbxref=dbSNP:rs17057718
IL17RD	Q8NFM7	289	326	306	306	Natural variant	ID=VAR_069938;Note=In HH18%3B reduced activity. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=PMID:23643382
MCTP2	Q6DN12	323	335	1	878	Chain	ID=PRO_0000294472;Note=Multiple C2 and transmembrane domain-containing protein 2
MCTP2	Q6DN12	695	736	1	878	Chain	ID=PRO_0000294472;Note=Multiple C2 and transmembrane domain-containing protein 2
MCTP2	Q6DN12	736	750	1	878	Chain	ID=PRO_0000294472;Note=Multiple C2 and transmembrane domain-containing protein 2
MCTP2	Q6DN12	695	736	697	717	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCTP2	Q6DN12	323	335	1	412	Alternative sequence	ID=VSP_026662;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MCTP2	Q6DN12	323	335	200	878	Alternative sequence	ID=VSP_038982;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	695	736	200	878	Alternative sequence	ID=VSP_038982;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	736	750	200	878	Alternative sequence	ID=VSP_038982;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	695	736	696	750	Alternative sequence	ID=VSP_026664;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	736	750	696	750	Alternative sequence	ID=VSP_026664;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	695	736	696	718	Alternative sequence	ID=VSP_026665;Note=In isoform 4. VFLITVWNFELYMIPLALLLIFV->HRKEEPPLSMKCTLFSGDIGPSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	695	736	719	878	Alternative sequence	ID=VSP_026666;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	736	750	719	878	Alternative sequence	ID=VSP_026666;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTP2	Q6DN12	695	736	695	695	Natural variant	ID=VAR_073427;Note=Found in a patient with left-sided obstructive cardiac lesions%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23773997;Dbxref=dbSNP:rs370153540,PMID:23773997
IDO1	P14902	61	101	1	403	Chain	ID=PRO_0000215204;Note=Indoleamine 2%2C3-dioxygenase 1
IDO1	P14902	61	101	1	403	Chain	ID=PRO_0000215204;Note=Indoleamine 2%2C3-dioxygenase 1
IDO1	P14902	61	101	55	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	55	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	67	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	67	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	73	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	73	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
IDO1	P14902	61	101	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U72
MCTS1	Q9ULC4	4	54	1	181	Chain	ID=PRO_0000344786;Note=Malignant T-cell-amplified sequence 1
MCTS1	Q9ULC4	4	54	1	22	Alternative sequence	ID=VSP_034856;Note=In isoform 2. MFKKFDEKENVSNCIQLKTSVI->MENYSFLDKE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTS1	Q9ULC4	4	54	1	4	Alternative sequence	ID=VSP_041352;Note=In isoform 3. MFKK->MGKGR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTS1	Q9ULC4	4	54	25	25	Sequence conflict	Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCTS1	Q9ULC4	4	54	7	10	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	11	16	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	19	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	34	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	40	43	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	50	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MAD1L1	Q9Y6D9	453	472	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	406	453	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	329	357	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	50	97	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	453	472	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	406	453	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	329	357	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	50	97	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	453	472	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	406	453	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	329	357	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	50	97	1	718	Chain	ID=PRO_0000213800;Note=Mitotic spindle assembly checkpoint protein MAD1
MAD1L1	Q9Y6D9	329	357	301	340	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	329	357	301	340	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	329	357	301	340	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	453	472	380	532	Region	Note=Necessary for interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14978040;Dbxref=PMID:14978040
MAD1L1	Q9Y6D9	406	453	380	532	Region	Note=Necessary for interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14978040;Dbxref=PMID:14978040
MAD1L1	Q9Y6D9	453	472	380	532	Region	Note=Necessary for interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14978040;Dbxref=PMID:14978040
MAD1L1	Q9Y6D9	406	453	380	532	Region	Note=Necessary for interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14978040;Dbxref=PMID:14978040
MAD1L1	Q9Y6D9	453	472	380	532	Region	Note=Necessary for interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14978040;Dbxref=PMID:14978040
MAD1L1	Q9Y6D9	406	453	380	532	Region	Note=Necessary for interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14978040;Dbxref=PMID:14978040
MAD1L1	Q9Y6D9	453	472	439	480	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	406	453	439	480	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	453	472	439	480	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	406	453	439	480	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	453	472	439	480	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	406	453	439	480	Region	Note=Important for interaction with IK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351768;Dbxref=PMID:22351768
MAD1L1	Q9Y6D9	453	472	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	406	453	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	329	357	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	50	97	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	453	472	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	406	453	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	329	357	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	50	97	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	453	472	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	406	453	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	329	357	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	50	97	46	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAD1L1	Q9Y6D9	50	97	61	61	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MAD1L1	Q9Y6D9	50	97	61	61	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MAD1L1	Q9Y6D9	50	97	61	61	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MAD1L1	Q9Y6D9	406	453	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
MAD1L1	Q9Y6D9	406	453	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
MAD1L1	Q9Y6D9	406	453	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
MAD1L1	Q9Y6D9	50	97	61	61	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
MAD1L1	Q9Y6D9	50	97	61	61	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
MAD1L1	Q9Y6D9	50	97	61	61	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
MAD1L1	Q9Y6D9	50	97	1	65	Alternative sequence	ID=VSP_056160;Note=In isoform 2. MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLI->MLPARGCVRKRTVWPRLARVLIVTLLTLELSYAPLPCQLSGVPYNTGDPVGRWARPCIWPCPWHT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAD1L1	Q9Y6D9	50	97	1	65	Alternative sequence	ID=VSP_056160;Note=In isoform 2. MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLI->MLPARGCVRKRTVWPRLARVLIVTLLTLELSYAPLPCQLSGVPYNTGDPVGRWARPCIWPCPWHT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAD1L1	Q9Y6D9	50	97	1	65	Alternative sequence	ID=VSP_056160;Note=In isoform 2. MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLI->MLPARGCVRKRTVWPRLARVLIVTLLTLELSYAPLPCQLSGVPYNTGDPVGRWARPCIWPCPWHT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAD1L1	Q9Y6D9	50	97	66	157	Alternative sequence	ID=VSP_056161;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAD1L1	Q9Y6D9	50	97	66	157	Alternative sequence	ID=VSP_056161;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAD1L1	Q9Y6D9	50	97	66	157	Alternative sequence	ID=VSP_056161;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAD1L1	Q9Y6D9	50	97	59	59	Natural variant	ID=VAR_019708;Note=In a prostate cancer cell line%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11423979;Dbxref=dbSNP:rs121908982,PMID:11423979
MAD1L1	Q9Y6D9	50	97	59	59	Natural variant	ID=VAR_019708;Note=In a prostate cancer cell line%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11423979;Dbxref=dbSNP:rs121908982,PMID:11423979
MAD1L1	Q9Y6D9	50	97	59	59	Natural variant	ID=VAR_019708;Note=In a prostate cancer cell line%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11423979;Dbxref=dbSNP:rs121908982,PMID:11423979
IGFBP1	P08833	173	216	26	259	Chain	ID=PRO_0000014365;Note=Insulin-like growth factor-binding protein 1
IGFBP1	P08833	173	216	173	251	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
IGFBP1	P08833	173	216	193	193	Modified residue	Note=Phosphothreonine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
IGFBP1	P08833	173	216	194	194	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19765076,ECO:0000269|PubMed:26091039,ECO:0000269|PubMed:7678248;Dbxref=PMID:19765076,PMID:26091039,PMID:7678248
IGFBP1	P08833	173	216	199	199	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
IGFBP1	P08833	173	216	176	206	Disulfide bond	.
IGFBP1	P08833	173	216	183	183	Natural variant	ID=VAR_011905;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10;Dbxref=dbSNP:rs1065782
IGFBP1	P08833	173	216	213	213	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGFBP1	P08833	173	216	175	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZT3
IGFBP1	P08833	173	216	199	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZT3
IGFBP1	P08833	173	216	210	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZT3
IGFBP1	P08833	173	216	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZT3
IGFBP3	P17936	210	250	28	291	Chain	ID=PRO_0000014378;Note=Insulin-like growth factor-binding protein 3
IGFBP3	P17936	210	250	210	285	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
IGFBP3	P17936	210	250	213	240	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
IGFBP3	P17936	210	250	234	234	Natural variant	ID=VAR_025264;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs35712717
HPS5	Q9UPZ3	946	983	1	1129	Chain	ID=PRO_0000084054;Note=Hermansky-Pudlak syndrome 5 protein
HPS5	Q9UPZ3	906	945	1	1129	Chain	ID=PRO_0000084054;Note=Hermansky-Pudlak syndrome 5 protein
HPS5	Q9UPZ3	595	620	1	1129	Chain	ID=PRO_0000084054;Note=Hermansky-Pudlak syndrome 5 protein
HPS5	Q9UPZ3	275	298	1	1129	Chain	ID=PRO_0000084054;Note=Hermansky-Pudlak syndrome 5 protein
HPS5	Q9UPZ3	204	274	1	1129	Chain	ID=PRO_0000084054;Note=Hermansky-Pudlak syndrome 5 protein
HPS5	Q9UPZ3	36	73	1	1129	Chain	ID=PRO_0000084054;Note=Hermansky-Pudlak syndrome 5 protein
HPS5	Q9UPZ3	36	73	1	114	Alternative sequence	ID=VSP_007035;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:12548288,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:12548288,PMID:14702039,PMID:15489334
HPS5	Q9UPZ3	36	73	70	70	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC48A1	Q6P1K1	45	101	1	146	Chain	ID=PRO_0000348575;Note=Heme transporter HRG1
SLC48A1	Q6P1K1	45	101	40	60	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC48A1	Q6P1K1	45	101	74	94	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC48A1	Q6P1K1	45	101	1	57	Alternative sequence	ID=VSP_035184;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATF7IP2	Q5U623	320	365	1	682	Chain	ID=PRO_0000281784;Note=Activating transcription factor 7-interacting protein 2
ATF7IP2	Q5U623	320	365	1	682	Chain	ID=PRO_0000281784;Note=Activating transcription factor 7-interacting protein 2
ATF7IP2	Q5U623	320	365	328	378	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ATF7IP2	Q5U623	320	365	328	378	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRODH2	Q9UF12	410	446	1	536	Chain	ID=PRO_0000308623;Note=Hydroxyproline dehydrogenase
PRODH2	Q9UF12	302	354	1	536	Chain	ID=PRO_0000308623;Note=Hydroxyproline dehydrogenase
IL17RA	Q96F46	254	282	33	866	Chain	ID=PRO_0000011030;Note=Interleukin-17 receptor A
IL17RA	Q96F46	314	348	33	866	Chain	ID=PRO_0000011030;Note=Interleukin-17 receptor A
IL17RA	Q96F46	254	282	33	320	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RA	Q96F46	314	348	33	320	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RA	Q96F46	314	348	321	341	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RA	Q96F46	314	348	342	866	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RA	Q96F46	254	282	265	265	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19838198;Dbxref=PMID:19838198
IL17RA	Q96F46	254	282	245	276	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19838198;Dbxref=PMID:19838198
IL17RA	Q96F46	314	348	315	348	Alternative sequence	ID=VSP_053496;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
IL17RA	Q96F46	254	282	257	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HSA
IL17RA	Q96F46	254	282	266	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HSA
IL17RA	Q96F46	254	282	276	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HSA
IL17RB	Q9NRM6	282	315	18	502	Chain	ID=PRO_0000011032;Note=Interleukin-17 receptor B
IL17RB	Q9NRM6	282	315	18	292	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RB	Q9NRM6	282	315	293	313	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RB	Q9NRM6	282	315	314	502	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RB	Q9NRM6	282	315	283	283	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL17RB	Q9NRM6	282	315	250	288	Alternative sequence	ID=VSP_001740;Note=In isoform 2. LTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPG->VKFSELLWGGKGHRRLFHHSLLLRMSSLLSNALLPADTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10815801;Dbxref=PMID:10815801
IL17RB	Q9NRM6	282	315	289	502	Alternative sequence	ID=VSP_001741;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10815801;Dbxref=PMID:10815801
IGFBP2	P18065	224	271	36	325	Chain	ID=PRO_0000014370;Note=Insulin-like growth factor-binding protein 2
IGFBP2	P18065	224	271	224	306	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
IGFBP2	P18065	224	271	227	261	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00500,ECO:0000269|PubMed:17020769;Dbxref=PMID:17020769
IGFBP2	P18065	224	271	226	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H7T
IGFBP2	P18065	224	271	247	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H7T
IGFBP2	P18065	224	271	269	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H7T
ICAM1	P05362	393	475	28	532	Chain	ID=PRO_0000014783;Note=Intercellular adhesion molecule 1
ICAM1	P05362	393	475	28	480	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM1	P05362	393	475	412	464	Domain	Note=Ig-like C2-type 5
ICAM1	P05362	393	475	406	406	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM1	P05362	393	475	403	419	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1P53,ECO:0000269|PubMed:15099525;Dbxref=PMID:15099525
ICAM1	P05362	393	475	431	457	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1P53,ECO:0000269|PubMed:15099525;Dbxref=PMID:15099525
ICAM1	P05362	393	475	397	397	Natural variant	ID=VAR_014654;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs5497
ICAM1	P05362	393	475	469	469	Natural variant	ID=VAR_014187;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391210,ECO:0000269|PubMed:15572059,ECO:0000269|PubMed:1680919,ECO:0000269|PubMed:3340213,ECO:0000269|PubMed:3349522,ECO:0000269|PubMed:7525451;Dbxref=dbSNP:rs5498,PMID:10391210,PMID:15572059,PMID:1680919,PMID:3340213,PMID:3349522,PMID:7525451
ICAM1	P05362	393	475	378	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	400	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	405	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	422	425	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	428	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	434	436	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	449	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	453	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICAM1	P05362	393	475	464	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZ4
ICK	Q9UPZ9	497	540	1	632	Chain	ID=PRO_0000086007;Note=Serine/threonine-protein kinase ICK
ICK	Q9UPZ9	497	540	1	632	Chain	ID=PRO_0000086007;Note=Serine/threonine-protein kinase ICK
ICK	Q9UPZ9	497	540	293	632	Alternative sequence	ID=VSP_050753;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICK	Q9UPZ9	497	540	293	632	Alternative sequence	ID=VSP_050753;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IDH2	P48735	393	423	40	452	Chain	ID=PRO_0000014420;Note=Isocitrate dehydrogenase [NADP]%2C mitochondrial
IDH2	P48735	178	226	40	452	Chain	ID=PRO_0000014420;Note=Isocitrate dehydrogenase [NADP]%2C mitochondrial
IDH2	P48735	178	226	179	179	Site	Note=Critical for catalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
IDH2	P48735	178	226	180	180	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
IDH2	P48735	178	226	180	180	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54071
IDH2	P48735	178	226	193	193	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54071
IDH2	P48735	178	226	193	193	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54071
IDH2	P48735	178	226	199	199	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54071
IDH2	P48735	393	423	400	400	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54071
IDH2	P48735	393	423	413	413	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22416140;Dbxref=PMID:22416140
IDH2	P48735	393	423	413	413	Mutagenesis	Note=44-fold loss in activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22416140;Dbxref=PMID:22416140
IDH2	P48735	393	423	413	413	Mutagenesis	Note=20-fold decrease in Vmax. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22416140;Dbxref=PMID:22416140
IDH2	P48735	393	423	413	413	Mutagenesis	Note=No appreciable difference in Km for isocitrate and NADP. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22416140;Dbxref=PMID:22416140
IDH2	P48735	178	226	177	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	178	226	182	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	178	226	190	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	178	226	205	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	178	226	216	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	178	226	225	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	393	423	389	407	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	393	423	413	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
IDH2	P48735	393	423	422	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I95
MEMO1	Q9Y316	48	70	1	297	Chain	ID=PRO_0000134394;Note=Protein MEMO1
MEMO1	Q9Y316	48	70	1	297	Chain	ID=PRO_0000134394;Note=Protein MEMO1
MEMO1	Q9Y316	48	70	49	71	Alternative sequence	ID=VSP_041092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MEMO1	Q9Y316	48	70	49	71	Alternative sequence	ID=VSP_041092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MEMO1	Q9Y316	48	70	49	49	Mutagenesis	Note=Abolishes interaction with ERBB2. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18045866;Dbxref=PMID:18045866
MEMO1	Q9Y316	48	70	49	49	Mutagenesis	Note=Abolishes interaction with ERBB2. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18045866;Dbxref=PMID:18045866
MEMO1	Q9Y316	48	70	54	54	Mutagenesis	Note=Diminishes interaction with ERBB2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18045866;Dbxref=PMID:18045866
MEMO1	Q9Y316	48	70	54	54	Mutagenesis	Note=Diminishes interaction with ERBB2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18045866;Dbxref=PMID:18045866
MEMO1	Q9Y316	48	70	52	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BCZ
MEMO1	Q9Y316	48	70	52	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BCZ
MEMO1	Q9Y316	48	70	68	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BCZ
MEMO1	Q9Y316	48	70	68	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BCZ
IFT81	Q8WYA0	143	173	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	347	396	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	446	489	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	489	519	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	143	173	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	347	396	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	446	489	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	489	519	2	676	Chain	ID=PRO_0000020916;Note=Intraflagellar transport protein 81 homolog
IFT81	Q8WYA0	143	173	132	258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	143	173	132	258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	347	396	306	389	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	347	396	306	389	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	446	489	416	456	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	446	489	416	456	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	489	519	490	622	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	489	519	490	622	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT81	Q8WYA0	143	173	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	347	396	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	446	489	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	489	519	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	143	173	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	347	396	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	446	489	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	489	519	1	569	Alternative sequence	ID=VSP_018784;Note=In isoform CDV-1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
IFT81	Q8WYA0	446	489	432	676	Alternative sequence	ID=VSP_050696;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT81	Q8WYA0	489	519	432	676	Alternative sequence	ID=VSP_050696;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT81	Q8WYA0	446	489	432	676	Alternative sequence	ID=VSP_050696;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT81	Q8WYA0	489	519	432	676	Alternative sequence	ID=VSP_050696;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFT81	Q8WYA0	347	396	262	676	Natural variant	ID=VAR_080487;Note=In SRTD19%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	446	489	262	676	Natural variant	ID=VAR_080487;Note=In SRTD19%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	489	519	262	676	Natural variant	ID=VAR_080487;Note=In SRTD19%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	347	396	262	676	Natural variant	ID=VAR_080487;Note=In SRTD19%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	446	489	262	676	Natural variant	ID=VAR_080487;Note=In SRTD19%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	489	519	262	676	Natural variant	ID=VAR_080487;Note=In SRTD19%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	489	519	512	676	Natural variant	ID=VAR_080488;Note=In SRTD19. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT81	Q8WYA0	489	519	512	676	Natural variant	ID=VAR_080488;Note=In SRTD19. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27666822;Dbxref=PMID:27666822
IFT88	Q13099	7	39	1	833	Chain	ID=PRO_0000106391;Note=Intraflagellar transport protein 88 homolog
IFT88	Q13099	60	79	1	833	Chain	ID=PRO_0000106391;Note=Intraflagellar transport protein 88 homolog
IFT88	Q13099	380	408	1	833	Chain	ID=PRO_0000106391;Note=Intraflagellar transport protein 88 homolog
IFT88	Q13099	442	471	1	833	Chain	ID=PRO_0000106391;Note=Intraflagellar transport protein 88 homolog
IFT88	Q13099	676	698	1	833	Chain	ID=PRO_0000106391;Note=Intraflagellar transport protein 88 homolog
IFT88	Q13099	756	793	1	833	Chain	ID=PRO_0000106391;Note=Intraflagellar transport protein 88 homolog
IFT88	Q13099	442	471	424	457	Repeat	Note=TPR 5
IFT88	Q13099	442	471	459	492	Repeat	Note=TPR 6
IFT88	Q13099	676	698	663	696	Repeat	Note=TPR 12
IFT88	Q13099	7	39	1	9	Alternative sequence	ID=VSP_035429;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7633404;Dbxref=PMID:7633404
IFT88	Q13099	60	79	61	79	Alternative sequence	ID=VSP_040620;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IFT88	Q13099	380	408	383	383	Natural variant	ID=VAR_046464;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2442455,PMID:15489334
IFT88	Q13099	442	471	455	455	Natural variant	ID=VAR_046465;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7633404;Dbxref=dbSNP:rs9509307,PMID:7633404
IFT88	Q13099	380	408	388	388	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFT88	Q13099	380	408	389	389	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFT88	Q13099	380	408	407	407	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFT46	Q9NQC8	118	161	1	304	Chain	ID=PRO_0000085516;Note=Intraflagellar transport protein 46 homolog
HMGA2	P52926	83	94	2	109	Chain	ID=PRO_0000206711;Note=High mobility group protein HMGI-C
HMGA2	P52926	83	94	84	109	Alternative sequence	ID=VSP_042564;Note=In isoform 2. PQQVVQKKPAQEETEETSSQESAEED->DNLLPRTSSKKKTSLGNSTKRSH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15882911;Dbxref=PMID:15882911
HMGA2	P52926	83	94	84	109	Alternative sequence	ID=VSP_047772;Note=In isoform 3. PQQVVQKKPAQEETEETSSQESAEED->LQN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15882911;Dbxref=PMID:15882911
HMGA2	P52926	83	94	84	109	Alternative sequence	ID=VSP_047773;Note=In isoform 4. PQQVVQKKPAQEETEETSSQESAEED->WLLMKSPCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15882911;Dbxref=PMID:15882911
HMGA2	P52926	83	94	84	109	Alternative sequence	ID=VSP_047774;Note=In isoform 5. PQQVVQKKPAQEETEETSSQESAEED->LRAQALDSDGLGSNSGPSLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15882911;Dbxref=PMID:15882911
HMGA2	P52926	83	94	84	109	Alternative sequence	ID=VSP_047775;Note=In isoform 6. PQQVVQKKPAQEETEETSSQESAEED->EEFYIAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15882911;Dbxref=PMID:15882911
MCM4	P33991	199	231	2	863	Chain	ID=PRO_0000194101;Note=DNA replication licensing factor MCM4
MCM4	P33991	199	231	2	863	Chain	ID=PRO_0000194101;Note=DNA replication licensing factor MCM4
MCM4	P33991	199	231	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MCM4	P33991	199	231	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MCM4	P33991	199	231	206	206	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM4	P33991	199	231	206	206	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM5	P33992	98	141	2	734	Chain	ID=PRO_0000194107;Note=DNA replication licensing factor MCM5
MCM5	P33992	98	141	136	136	Natural variant	ID=VAR_014813;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs2307334
MCM9	Q9NXL9	509	577	1	1143	Chain	ID=PRO_0000089513;Note=DNA helicase MCM9
MCM9	Q9NXL9	301	343	1	1143	Chain	ID=PRO_0000089513;Note=DNA helicase MCM9
MCM9	Q9NXL9	301	343	300	505	Domain	Note=MCM;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCM9	Q9NXL9	301	343	1	381	Alternative sequence	ID=VSP_044180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCM9	Q9NXL9	509	577	392	1143	Alternative sequence	ID=VSP_028014;Note=In isoform S. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCM9	Q9NXL9	509	577	558	558	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL12RB2	Q99665	519	572	24	862	Chain	ID=PRO_0000010920;Note=Interleukin-12 receptor subunit beta-2
IL12RB2	Q99665	572	618	24	862	Chain	ID=PRO_0000010920;Note=Interleukin-12 receptor subunit beta-2
IL12RB2	Q99665	519	572	24	622	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB2	Q99665	572	618	24	622	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12RB2	Q99665	519	572	423	520	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB2	Q99665	519	572	521	620	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB2	Q99665	572	618	521	620	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL12RB2	Q99665	519	572	487	572	Alternative sequence	ID=VSP_044784;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IL12RB2	Q99665	572	618	487	572	Alternative sequence	ID=VSP_044784;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ICA1	Q05084	353	443	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	318	339	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	235	268	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	193	235	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	353	443	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	318	339	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	235	268	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	193	235	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	353	443	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	318	339	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	235	268	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	193	235	1	483	Chain	ID=PRO_0000084130;Note=Islet cell autoantigen 1
ICA1	Q05084	235	268	51	254	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1	Q05084	193	235	51	254	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1	Q05084	235	268	51	254	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1	Q05084	193	235	51	254	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1	Q05084	235	268	51	254	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICA1	Q05084	193	235	51	254	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ICAM2	P13598	20	109	1	24	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
ICAM2	P13598	20	109	1	24	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
ICAM2	P13598	20	109	1	24	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
ICAM2	P13598	20	109	1	24	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
ICAM2	P13598	20	109	1	24	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
ICAM2	P13598	20	109	25	275	Chain	ID=PRO_0000014790;Note=Intercellular adhesion molecule 2
ICAM2	P13598	20	109	25	275	Chain	ID=PRO_0000014790;Note=Intercellular adhesion molecule 2
ICAM2	P13598	20	109	25	275	Chain	ID=PRO_0000014790;Note=Intercellular adhesion molecule 2
ICAM2	P13598	20	109	25	275	Chain	ID=PRO_0000014790;Note=Intercellular adhesion molecule 2
ICAM2	P13598	20	109	25	275	Chain	ID=PRO_0000014790;Note=Intercellular adhesion molecule 2
ICAM2	P13598	20	109	25	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM2	P13598	20	109	25	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM2	P13598	20	109	25	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM2	P13598	20	109	25	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM2	P13598	20	109	25	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM2	P13598	20	109	41	98	Domain	Note=Ig-like C2-type 1
ICAM2	P13598	20	109	41	98	Domain	Note=Ig-like C2-type 1
ICAM2	P13598	20	109	41	98	Domain	Note=Ig-like C2-type 1
ICAM2	P13598	20	109	41	98	Domain	Note=Ig-like C2-type 1
ICAM2	P13598	20	109	41	98	Domain	Note=Ig-like C2-type 1
ICAM2	P13598	20	109	47	47	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	47	47	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	47	47	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	47	47	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	47	47	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	82	82	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	82	82	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	82	82	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	82	82	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	82	82	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:16335952,PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:16335952,PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:16335952,PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:16335952,PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:9153399;Dbxref=PMID:16335952,PMID:19349973,PMID:9153399
ICAM2	P13598	20	109	48	91	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	48	91	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	48	91	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	48	91	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	48	91	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	52	95	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	52	95	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	52	95	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	52	95	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	52	95	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1ZXQ,ECO:0000269|PubMed:9153399;Dbxref=PMID:9153399
ICAM2	P13598	20	109	37	37	Natural variant	ID=VAR_014655;Note=A->T;Dbxref=dbSNP:rs5503
ICAM2	P13598	20	109	37	37	Natural variant	ID=VAR_014655;Note=A->T;Dbxref=dbSNP:rs5503
ICAM2	P13598	20	109	37	37	Natural variant	ID=VAR_014655;Note=A->T;Dbxref=dbSNP:rs5503
ICAM2	P13598	20	109	37	37	Natural variant	ID=VAR_014655;Note=A->T;Dbxref=dbSNP:rs5503
ICAM2	P13598	20	109	37	37	Natural variant	ID=VAR_014655;Note=A->T;Dbxref=dbSNP:rs5503
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	65	65	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ICAM2	P13598	20	109	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	42	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	42	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	42	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	42	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	42	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	63	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	63	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	63	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	63	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	63	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	87	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	87	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	87	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	87	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	87	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	98	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	98	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	98	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	98	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
ICAM2	P13598	20	109	98	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZXQ
MFSD2B	A6NFX1	298	326	1	504	Chain	ID=PRO_0000341260;Note=Major facilitator superfamily domain-containing protein 2B
MFSD2B	A6NFX1	298	326	287	307	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2B	A6NFX1	298	326	320	340	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	288	332	1	518	Chain	ID=PRO_0000311232;Note=Major facilitator superfamily domain-containing protein 8
MFSD8	Q8NHS3	146	184	1	518	Chain	ID=PRO_0000311232;Note=Major facilitator superfamily domain-containing protein 8
MFSD8	Q8NHS3	146	184	132	152	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	146	184	153	173	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	146	184	174	194	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	288	332	288	304	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	288	332	305	325	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	288	332	326	337	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD8	Q8NHS3	146	184	147	184	Alternative sequence	ID=VSP_057055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFSD8	Q8NHS3	288	332	237	518	Alternative sequence	ID=VSP_057057;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFSD8	Q8NHS3	146	184	157	157	Natural variant	ID=VAR_058430;Note=In CLN7%3B due to a deletion-insertion mutation at nucleotide level. A->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19201763,ECO:0000269|PubMed:21990111;Dbxref=PMID:19201763,PMID:21990111
MFSD8	Q8NHS3	146	184	160	160	Natural variant	ID=VAR_066915;Note=In CLN7. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990111;Dbxref=dbSNP:rs1162750836,PMID:21990111
MFSD8	Q8NHS3	146	184	160	160	Natural variant	ID=VAR_066916;Note=In CLN7. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990111;Dbxref=PMID:21990111
MFSD8	Q8NHS3	288	332	294	294	Natural variant	ID=VAR_058431;Note=In CLN7. T->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19177532,ECO:0000269|PubMed:19201763,ECO:0000269|PubMed:22612257;Dbxref=dbSNP:rs140948465,PMID:19177532,PMID:19201763,PMID:22612257
MFSD8	Q8NHS3	288	332	310	310	Natural variant	ID=VAR_037177;Note=In CLN7%3B lysosomal localization. G->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17564970,ECO:0000269|PubMed:19177532,ECO:0000269|PubMed:19201763;Dbxref=dbSNP:rs118203975,PMID:17564970,PMID:19177532,PMID:19201763
NFKBIZ	Q9BYH8	608	645	1	718	Chain	ID=PRO_0000323577;Note=NF-kappa-B inhibitor zeta
NFKBIZ	Q9BYH8	608	645	612	641	Repeat	Note=ANK 6
NFKBIZ	Q9BYH8	608	645	404	718	Region	Note=Interaction with NFKB1/p50;Ontology_term=ECO:0000250;evidence=ECO:0000250
IZUMO4	Q1ZYL8	185	202	16	232	Chain	ID=PRO_0000278186;Note=Izumo sperm-egg fusion protein 4
IZUMO4	Q1ZYL8	185	202	158	232	Alternative sequence	ID=VSP_023148;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
IZUMO4	Q1ZYL8	185	202	159	232	Alternative sequence	ID=VSP_023149;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IZUMO4	Q1ZYL8	185	202	185	203	Alternative sequence	ID=VSP_023150;Note=In isoform 2. RPRSSAFSWPGTHRATPAF->S;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1,ECO:0000303|Ref.2;Dbxref=PMID:15489334
JAG1	P78504	742	781	34	1218	Chain	ID=PRO_0000007625;Note=Protein jagged-1
JAG1	P78504	704	742	34	1218	Chain	ID=PRO_0000007625;Note=Protein jagged-1
JAG1	P78504	666	704	34	1218	Chain	ID=PRO_0000007625;Note=Protein jagged-1
JAG1	P78504	628	666	34	1218	Chain	ID=PRO_0000007625;Note=Protein jagged-1
JAG1	P78504	573	628	34	1218	Chain	ID=PRO_0000007625;Note=Protein jagged-1
JAG1	P78504	373	411	34	1218	Chain	ID=PRO_0000007625;Note=Protein jagged-1
JAG1	P78504	742	781	34	1067	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	704	742	34	1067	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	666	704	34	1067	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	628	666	34	1067	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	573	628	34	1067	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	373	411	34	1067	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	373	411	374	410	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG1	P78504	573	628	586	627	Domain	Note=EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG1	P78504	628	666	629	665	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG1	P78504	666	704	667	703	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG1	P78504	704	742	705	741	Domain	Note=EGF-like 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG1	P78504	742	781	744	780	Domain	Note=EGF-like 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG1	P78504	373	411	382	382	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	742	781	745	745	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG1	P78504	373	411	378	389	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	373	411	383	398	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	373	411	400	409	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	573	628	578	605	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	573	628	599	615	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	573	628	617	626	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	628	666	633	644	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	628	666	638	653	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	628	666	655	664	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	666	704	671	682	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	666	704	676	691	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	666	704	693	702	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	704	742	709	720	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	704	742	714	729	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	704	742	731	740	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	742	781	748	759	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	742	781	753	768	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	742	781	770	779	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG1	P78504	373	411	386	386	Natural variant	ID=VAR_013203;Note=In ALGS1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11058898;Dbxref=dbSNP:rs863223650,PMID:11058898
JAG1	P78504	628	666	664	664	Natural variant	ID=VAR_080875;Note=Found in a patient with pulmonary stenosis%3B unknown pathological significance%3B the mutant is able to activate Notch signaling. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20437614;Dbxref=PMID:20437614
JAG1	P78504	666	704	690	690	Natural variant	ID=VAR_026324;Note=In biliary atresia%3B extrahepatic. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12297837;Dbxref=PMID:12297837
JAG1	P78504	666	704	693	693	Natural variant	ID=VAR_026325;Note=In ALGS1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16575836;Dbxref=dbSNP:rs566563238,PMID:16575836
JAG1	P78504	704	742	714	714	Natural variant	ID=VAR_026326;Note=In ALGS1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11180599;Dbxref=PMID:11180599
JAG1	P78504	704	742	731	731	Natural variant	ID=VAR_013205;Note=In ALGS1. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10220506;Dbxref=PMID:10220506
JAG1	P78504	704	742	740	740	Natural variant	ID=VAR_013206;Note=In ALGS1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10220506;Dbxref=PMID:10220506
JAG1	P78504	742	781	753	753	Natural variant	ID=VAR_013207;Note=In ALGS1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11139247;Dbxref=PMID:11139247
ITPR2	Q14571	317	332	1	2701	Chain	ID=PRO_0000153924;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 2
ITPR2	Q14571	317	332	1	2227	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR2	Q14571	317	332	294	372	Domain	Note=MIR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131
ITPR2	Q14571	317	332	182	2701	Alternative sequence	ID=VSP_002700;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9729462;Dbxref=PMID:9729462
JAM3	Q9BX67	85	136	32	310	Chain	ID=PRO_0000015071;Note=Junctional adhesion molecule C
JAM3	Q9BX67	85	136	32	241	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM3	Q9BX67	85	136	35	127	Domain	Note=Ig-like V-type
JAM3	Q9BX67	85	136	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM3	Q9BX67	85	136	53	115	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
JAM3	Q9BX67	85	136	85	135	Alternative sequence	ID=VSP_042561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
JAM3	Q9BX67	85	136	116	116	Natural variant	ID=VAR_069529;Note=In HDBSCC%3B normal location at the cell membrane. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23255084;Dbxref=dbSNP:rs397515439,PMID:23255084
JAM3	Q9BX67	85	136	136	136	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAPK8IP3	Q9UPT6	939	978	1	1336	Chain	ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3
MAPK8IP3	Q9UPT6	979	1005	1	1336	Chain	ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3
MAPK8IP3	Q9UPT6	1135	1173	1	1336	Chain	ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3
MAPK8IP3	Q9UPT6	1173	1186	1	1336	Chain	ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3
MAPK8IP3	Q9UPT6	939	978	251	1336	Alternative sequence	ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
MAPK8IP3	Q9UPT6	979	1005	251	1336	Alternative sequence	ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
MAPK8IP3	Q9UPT6	1135	1173	251	1336	Alternative sequence	ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
MAPK8IP3	Q9UPT6	1173	1186	251	1336	Alternative sequence	ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
JAKMIP3	Q5VZ66	211	283	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
JAKMIP3	Q5VZ66	738	806	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
JAKMIP3	Q5VZ66	211	283	8	258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP3	Q5VZ66	738	806	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP3	Q5VZ66	211	283	1	563	Alternative sequence	ID=VSP_031998;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
JAKMIP3	Q5VZ66	738	806	795	795	Natural variant	ID=VAR_039473;Note=In a breast cancer sample%3B somatic mutation. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
KIAA0100	Q14667	2130	2175	32	2235	Chain	ID=PRO_0000248587;Note=Protein KIAA0100
KIAA0100	Q14667	2096	2130	32	2235	Chain	ID=PRO_0000248587;Note=Protein KIAA0100
KIAA0100	Q14667	1970	2007	32	2235	Chain	ID=PRO_0000248587;Note=Protein KIAA0100
KIAA0100	Q14667	1941	1970	32	2235	Chain	ID=PRO_0000248587;Note=Protein KIAA0100
KIAA0100	Q14667	1584	1653	32	2235	Chain	ID=PRO_0000248587;Note=Protein KIAA0100
KIAA0100	Q14667	1023	1087	32	2235	Chain	ID=PRO_0000248587;Note=Protein KIAA0100
KIAA0100	Q14667	1584	1653	1	1846	Alternative sequence	ID=VSP_020317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA0100	Q14667	1023	1087	1	1846	Alternative sequence	ID=VSP_020317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA0100	Q14667	2130	2175	366	2235	Alternative sequence	ID=VSP_020320;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16289875;Dbxref=PMID:15489334,PMID:16289875
KIAA0100	Q14667	2096	2130	366	2235	Alternative sequence	ID=VSP_020320;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16289875;Dbxref=PMID:15489334,PMID:16289875
KIAA0100	Q14667	1970	2007	366	2235	Alternative sequence	ID=VSP_020320;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16289875;Dbxref=PMID:15489334,PMID:16289875
KIAA0100	Q14667	1941	1970	366	2235	Alternative sequence	ID=VSP_020320;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16289875;Dbxref=PMID:15489334,PMID:16289875
KIAA0100	Q14667	1584	1653	366	2235	Alternative sequence	ID=VSP_020320;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16289875;Dbxref=PMID:15489334,PMID:16289875
KIAA0100	Q14667	1023	1087	366	2235	Alternative sequence	ID=VSP_020320;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16289875;Dbxref=PMID:15489334,PMID:16289875
KIAA0100	Q14667	1941	1970	1968	1968	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIAA0232	Q92628	77	123	1	1395	Chain	ID=PRO_0000050738;Note=Uncharacterized protein KIAA0232
KIAA0232	Q92628	77	123	1	1395	Chain	ID=PRO_0000050738;Note=Uncharacterized protein KIAA0232
KIAA0232	Q92628	77	123	89	96	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA0232	Q92628	77	123	89	96	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMADHC	Q9H3L0	203	232	39	296	Chain	ID=PRO_0000019534;Note=Methylmalonic aciduria and homocystinuria type D protein%2C mitochondrial
MMADHC	Q9H3L0	203	232	39	296	Chain	ID=PRO_0000019534;Note=Methylmalonic aciduria and homocystinuria type D protein%2C mitochondrial
MMADHC	Q9H3L0	203	232	203	203	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MMADHC	Q9H3L0	203	232	203	203	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MMADHC	Q9H3L0	203	232	204	232	Natural variant	ID=VAR_043845;Note=In MAHCD%3B cblD original. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18385497;Dbxref=PMID:18385497
MMADHC	Q9H3L0	203	232	204	232	Natural variant	ID=VAR_043845;Note=In MAHCD%3B cblD original. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18385497;Dbxref=PMID:18385497
MMADHC	Q9H3L0	203	232	204	204	Mutagenesis	Note=Decreases methylcobalamin levels and mildly increases adenosylcobalamin levels. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24722857;Dbxref=PMID:24722857
MMADHC	Q9H3L0	203	232	204	204	Mutagenesis	Note=Decreases methylcobalamin levels and mildly increases adenosylcobalamin levels. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24722857;Dbxref=PMID:24722857
MMADHC	Q9H3L0	203	232	212	212	Mutagenesis	Note=No effect on cobalamin levels. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24722857;Dbxref=PMID:24722857
MMADHC	Q9H3L0	203	232	212	212	Mutagenesis	Note=No effect on cobalamin levels. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24722857;Dbxref=PMID:24722857
MMADHC	Q9H3L0	203	232	226	226	Mutagenesis	Note=Decreases methylcobalamin levels%2C but increases adenosylcobalamin levels. No effect on interaction with MMACHC. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24722857,ECO:0000269|PubMed:26483544;Dbxref=PMID:24722857,PMID:26483544
MMADHC	Q9H3L0	203	232	226	226	Mutagenesis	Note=Decreases methylcobalamin levels%2C but increases adenosylcobalamin levels. No effect on interaction with MMACHC. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24722857,ECO:0000269|PubMed:26483544;Dbxref=PMID:24722857,PMID:26483544
MMADHC	Q9H3L0	203	232	204	204	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMADHC	Q9H3L0	203	232	204	204	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMADHC	Q9H3L0	203	232	211	211	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMADHC	Q9H3L0	203	232	211	211	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMADHC	Q9H3L0	203	232	191	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	191	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	231	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMADHC	Q9H3L0	203	232	231	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CV0
MMEL1	Q495T6	689	721	1	779	Chain	ID=PRO_0000248415;Note=Membrane metallo-endopeptidase-like 1
MMEL1	Q495T6	424	467	1	779	Chain	ID=PRO_0000248415;Note=Membrane metallo-endopeptidase-like 1
MMEL1	Q495T6	51	77	1	779	Chain	ID=PRO_0000248415;Note=Membrane metallo-endopeptidase-like 1
MMEL1	Q495T6	689	721	74	779	Chain	ID=PRO_0000248416;Note=Membrane metallo-endopeptidase-like 1%2C soluble form;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	424	467	74	779	Chain	ID=PRO_0000248416;Note=Membrane metallo-endopeptidase-like 1%2C soluble form;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	51	77	74	779	Chain	ID=PRO_0000248416;Note=Membrane metallo-endopeptidase-like 1%2C soluble form;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	689	721	49	779	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMEL1	Q495T6	424	467	49	779	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMEL1	Q495T6	51	77	49	779	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMEL1	Q495T6	51	77	73	74	Site	Note=Cleavage;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	689	721	112	764	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	424	467	112	764	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	689	721	120	724	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	424	467	120	724	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	424	467	175	439	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	689	721	650	776	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMEL1	Q495T6	689	721	612	779	Alternative sequence	ID=VSP_020289;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA0930	Q6ICG6	219	284	1	404	Chain	ID=PRO_0000255938;Note=Uncharacterized protein KIAA0930
KIAA0930	Q6ICG6	219	284	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
KIAA0930	Q6ICG6	219	284	276	276	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UE31
KIAA0930	Q6ICG6	219	284	279	279	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
KRT5	P13647	364	406	1	590	Chain	ID=PRO_0000063727;Note=Keratin%2C type II cytoskeletal 5
KRT5	P13647	364	406	168	481	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT5	P13647	364	406	339	477	Region	Note=Coil 2
KRT5	P13647	364	406	387	387	Natural variant	ID=VAR_028766;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10903910,ECO:0000269|PubMed:2456903;Dbxref=dbSNP:rs2669875,PMID:10903910,PMID:2456903
KRT5	P13647	364	406	404	404	Natural variant	ID=VAR_023726;Note=In WC-EBS. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655565;Dbxref=dbSNP:rs60809982,PMID:12655565
KRT5	P13647	364	406	375	375	Sequence conflict	Note=H->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
KRT5	P13647	364	406	383	472	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TNU
KIAA2026	Q5HYC2	764	794	1	2103	Chain	ID=PRO_0000288922;Note=Uncharacterized protein KIAA2026
KIAA2026	Q5HYC2	198	264	1	2103	Chain	ID=PRO_0000288922;Note=Uncharacterized protein KIAA2026
KIAA2026	Q5HYC2	764	794	765	794	Alternative sequence	ID=VSP_039334;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MMS22L	Q6ZRQ5	1161	1216	1	1243	Chain	ID=PRO_0000260216;Note=Protein MMS22-like
MMS22L	Q6ZRQ5	394	434	1	1243	Chain	ID=PRO_0000260216;Note=Protein MMS22-like
MMS22L	Q6ZRQ5	276	314	1	1243	Chain	ID=PRO_0000260216;Note=Protein MMS22-like
MMS22L	Q6ZRQ5	394	434	419	419	Natural variant	ID=VAR_029013;Note=N->D;Dbxref=dbSNP:rs9374435
MMS22L	Q6ZRQ5	276	314	292	292	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MNDA	P41218	134	190	1	407	Chain	ID=PRO_0000153724;Note=Myeloid cell nuclear differentiation antigen
MNDA	P41218	190	329	1	407	Chain	ID=PRO_0000153724;Note=Myeloid cell nuclear differentiation antigen
MNDA	P41218	190	329	196	394	Domain	Note=HIN-200;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00106
MNDA	P41218	134	190	131	137	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MNDA	P41218	134	190	156	156	Natural variant	ID=VAR_034107;Note=S->R;Dbxref=dbSNP:rs35417083
MNDA	P41218	190	329	286	286	Natural variant	ID=VAR_012055;Note=V->L;Dbxref=dbSNP:rs1056771
PRKAR1B	P31321	183	236	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	59	116	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	183	236	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	59	116	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	183	236	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	59	116	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	183	236	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	59	116	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	183	236	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	59	116	2	381	Chain	ID=PRO_0000205381;Note=cAMP-dependent protein kinase type I-beta regulatory subunit
PRKAR1B	P31321	183	236	137	254	Nucleotide binding	Note=cAMP 1
PRKAR1B	P31321	183	236	137	254	Nucleotide binding	Note=cAMP 1
PRKAR1B	P31321	183	236	137	254	Nucleotide binding	Note=cAMP 1
PRKAR1B	P31321	183	236	137	254	Nucleotide binding	Note=cAMP 1
PRKAR1B	P31321	183	236	137	254	Nucleotide binding	Note=cAMP 1
PRKAR1B	P31321	59	116	2	136	Region	Note=Dimerization and phosphorylation
PRKAR1B	P31321	59	116	2	136	Region	Note=Dimerization and phosphorylation
PRKAR1B	P31321	59	116	2	136	Region	Note=Dimerization and phosphorylation
PRKAR1B	P31321	59	116	2	136	Region	Note=Dimerization and phosphorylation
PRKAR1B	P31321	59	116	2	136	Region	Note=Dimerization and phosphorylation
PRKAR1B	P31321	59	116	96	100	Motif	Note=Pseudophosphorylation motif
PRKAR1B	P31321	59	116	96	100	Motif	Note=Pseudophosphorylation motif
PRKAR1B	P31321	59	116	96	100	Motif	Note=Pseudophosphorylation motif
PRKAR1B	P31321	59	116	96	100	Motif	Note=Pseudophosphorylation motif
PRKAR1B	P31321	59	116	96	100	Motif	Note=Pseudophosphorylation motif
PRKAR1B	P31321	183	236	202	202	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	202	202	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	202	202	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	202	202	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	202	202	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	211	211	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	211	211	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	211	211	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	211	211	Binding site	Note=cAMP 1
PRKAR1B	P31321	183	236	211	211	Binding site	Note=cAMP 1
PRKAR1B	P31321	59	116	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRKAR1B	P31321	59	116	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRKAR1B	P31321	59	116	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRKAR1B	P31321	59	116	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRKAR1B	P31321	59	116	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRKAR1B	P31321	59	116	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569
PRKAR1B	P31321	59	116	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569
PRKAR1B	P31321	59	116	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569
PRKAR1B	P31321	59	116	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569
PRKAR1B	P31321	59	116	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569
PRKAR1B	P31321	59	116	85	85	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	85	85	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	85	85	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	85	85	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	85	85	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	97	97	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	97	97	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	97	97	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	97	97	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	97	97	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12849
PRKAR1B	P31321	59	116	46	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9K
PRKAR1B	P31321	59	116	46	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9K
PRKAR1B	P31321	59	116	46	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9K
PRKAR1B	P31321	59	116	46	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9K
PRKAR1B	P31321	59	116	46	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9K
KANK2	Q63ZY3	804	834	1	851	Chain	ID=PRO_0000240840;Note=KN motif and ankyrin repeat domain-containing protein 2
KANK2	Q63ZY3	804	834	805	835	Repeat	Note=ANK 5
KANK2	Q63ZY3	804	834	669	835	Region	Note=Interaction with NCOA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17476305;Dbxref=PMID:17476305
KANK2	Q63ZY3	804	834	809	816	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBD
KANK2	Q63ZY3	804	834	819	828	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBD
KANK3	Q6NY19	11	442	1	840	Chain	ID=PRO_0000244582;Note=KN motif and ankyrin repeat domain-containing protein 3
KANK3	Q6NY19	11	442	181	230	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK3	Q6NY19	11	442	367	404	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK3	Q6NY19	11	442	152	152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK3	Q6NY19	11	442	160	160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1P7
KANK3	Q6NY19	11	442	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1P7
KANK3	Q6NY19	11	442	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK3	Q6NY19	11	442	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK3	Q6NY19	11	442	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK3	Q6NY19	11	442	271	271	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK3	Q6NY19	11	442	280	280	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1P7
KANK3	Q6NY19	11	442	293	293	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK3	Q6NY19	11	442	288	288	Natural variant	ID=VAR_026909;Note=D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs890850,PMID:14702039
KANK3	Q6NY19	11	442	359	359	Natural variant	ID=VAR_026910;Note=R->H;Dbxref=dbSNP:rs890853
KANK4	Q5T7N3	894	961	1	995	Chain	ID=PRO_0000244364;Note=KN motif and ankyrin repeat domain-containing protein 4
KANK4	Q5T7N3	5	633	1	995	Chain	ID=PRO_0000244364;Note=KN motif and ankyrin repeat domain-containing protein 4
KANK4	Q5T7N3	894	961	895	924	Repeat	Note=ANK 3
KANK4	Q5T7N3	894	961	928	958	Repeat	Note=ANK 4
KANK4	Q5T7N3	5	633	343	404	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK4	Q5T7N3	5	633	184	315	Compositional bias	Note=Pro-rich
KANK4	Q5T7N3	5	633	1	628	Alternative sequence	ID=VSP_019552;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KANK4	Q5T7N3	5	633	629	633	Alternative sequence	ID=VSP_019553;Note=In isoform 2. SSPPV->MEKTD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KANK4	Q5T7N3	894	961	935	935	Natural variant	ID=VAR_026904;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs2941679,PMID:14702039,PMID:15489334,PMID:17974005
KANK4	Q5T7N3	5	633	297	297	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
GCAT	O75600	143	192	22	419	Chain	ID=PRO_0000001246;Note=2-amino-3-ketobutyrate coenzyme A ligase%2C mitochondrial
GCAT	O75600	143	192	159	159	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GCAT	O75600	143	192	187	187	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88986
GCAT	O75600	143	192	187	187	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88986
CSNK1G2	P78368	334	362	1	415	Chain	ID=PRO_0000192842;Note=Casein kinase I isoform gamma-2
CAMK1	Q14012	28	71	1	370	Chain	ID=PRO_0000086076;Note=Calcium/calmodulin-dependent protein kinase type 1
CAMK1	Q14012	28	71	20	276	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CAMK1	Q14012	28	71	26	34	Nucleotide binding	Note=ATP
CAMK1	Q14012	28	71	49	49	Binding site	Note=ATP
CAMK1	Q14012	28	71	59	59	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23707388;Dbxref=PMID:23707388
CAMK1	Q14012	28	71	49	49	Mutagenesis	Note=Catalytically inactive form%3B prevents CDK4 activation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14754892,ECO:0000269|PubMed:7641687;Dbxref=PMID:14754892,PMID:7641687
CAMK1	Q14012	28	71	20	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FG8
CAMK1	Q14012	28	71	32	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FG8
CAMK1	Q14012	28	71	40	42	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FG8
CAMK1	Q14012	28	71	45	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FG8
CAMK1	Q14012	28	71	66	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FG8
PNCK	Q6P2M8	23	66	1	343	Chain	ID=PRO_0000086079;Note=Calcium/calmodulin-dependent protein kinase type 1B
PNCK	Q6P2M8	23	66	1	343	Chain	ID=PRO_0000086079;Note=Calcium/calmodulin-dependent protein kinase type 1B
PNCK	Q6P2M8	23	66	15	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PNCK	Q6P2M8	23	66	15	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PNCK	Q6P2M8	23	66	21	29	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PNCK	Q6P2M8	23	66	21	29	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PNCK	Q6P2M8	23	66	44	44	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PNCK	Q6P2M8	23	66	44	44	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PNCK	Q6P2M8	23	66	1	102	Alternative sequence	ID=VSP_012634;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PNCK	Q6P2M8	23	66	1	102	Alternative sequence	ID=VSP_012634;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KRTCAP3	Q53RY4	71	91	1	240	Chain	ID=PRO_0000226985;Note=Keratinocyte-associated protein 3
KRTCAP3	Q53RY4	91	160	1	240	Chain	ID=PRO_0000226985;Note=Keratinocyte-associated protein 3
KRTCAP3	Q53RY4	71	91	1	240	Chain	ID=PRO_0000226985;Note=Keratinocyte-associated protein 3
KRTCAP3	Q53RY4	91	160	1	240	Chain	ID=PRO_0000226985;Note=Keratinocyte-associated protein 3
KRTCAP3	Q53RY4	71	91	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KRTCAP3	Q53RY4	71	91	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KRTCAP3	Q53RY4	91	160	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KRTCAP3	Q53RY4	91	160	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KRTCAP3	Q53RY4	71	91	79	79	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
KRTCAP3	Q53RY4	71	91	79	79	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCNT1	Q5JUK3	52	65	1	1230	Chain	ID=PRO_0000054090;Note=Potassium channel subfamily T member 1
KCNT1	Q5JUK3	521	570	1	1230	Chain	ID=PRO_0000054090;Note=Potassium channel subfamily T member 1
KCNT1	Q5JUK3	822	845	1	1230	Chain	ID=PRO_0000054090;Note=Potassium channel subfamily T member 1
KCNT1	Q5JUK3	1146	1167	1	1230	Chain	ID=PRO_0000054090;Note=Potassium channel subfamily T member 1
KCNT1	Q5JUK3	52	65	1	97	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT1	Q5JUK3	521	570	326	1230	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT1	Q5JUK3	822	845	326	1230	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT1	Q5JUK3	1146	1167	326	1230	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT1	Q5JUK3	521	570	475	596	Domain	Note=RCK N-terminal
KCNT1	Q5JUK3	52	65	1	66	Alternative sequence	ID=VSP_015470;Note=In isoform 2 and isoform 3. MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSLDSSLSQ->MPLPDGARTPGGVCREARGGGYTNRTFEFDDGQCAPRRPCAGDGALLDTAGFKMSDLDSEVLPLPPRYRFRDLLLGDPSFQNDDR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15489334;Dbxref=PMID:10718198,PMID:15489334
KCNT1	Q5JUK3	52	65	1	66	Alternative sequence	ID=VSP_055700;Note=In isoform 4. MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSLDSSLSQ->MPLPDGARTPGGVCREARGGGYTNRTFEFDDGQCAPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KCNT1	Q5JUK3	1146	1167	1142	1162	Alternative sequence	ID=VSP_044476;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KCNT1	Q5JUK3	521	570	562	562	Natural variant	ID=VAR_078641;Note=In EIEE14%3B unknown pathological significance. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
KCNT1	Q5JUK3	822	845	822	822	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFI6	P09912	49	99	1	130	Chain	ID=PRO_0000008741;Note=Interferon alpha-inducible protein 6
IFI6	P09912	23	49	1	130	Chain	ID=PRO_0000008741;Note=Interferon alpha-inducible protein 6
IFI6	P09912	23	49	4	24	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI6	P09912	49	99	41	61	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI6	P09912	23	49	41	61	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI6	P09912	49	99	75	95	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI6	P09912	49	99	99	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IFI6	P09912	23	49	24	24	Alternative sequence	ID=VSP_001502;Note=In isoform B. G->GENAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IFI6	P09912	23	49	24	24	Alternative sequence	ID=VSP_001503;Note=In isoform C. G->GENAGKDAG;Ontology_term=ECO:0000305;evidence=ECO:0000305
INTU	Q9ULD6	256	324	1	942	Chain	ID=PRO_0000058296;Note=Protein inturned
INTU	Q9ULD6	364	393	1	942	Chain	ID=PRO_0000058296;Note=Protein inturned
INTU	Q9ULD6	483	501	1	942	Chain	ID=PRO_0000058296;Note=Protein inturned
INTU	Q9ULD6	501	522	1	942	Chain	ID=PRO_0000058296;Note=Protein inturned
INTU	Q9ULD6	256	324	185	263	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
INTU	Q9ULD6	483	501	409	942	Alternative sequence	ID=VSP_015074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTU	Q9ULD6	501	522	409	942	Alternative sequence	ID=VSP_015074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTU	Q9ULD6	483	501	436	942	Alternative sequence	ID=VSP_042587;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
INTU	Q9ULD6	501	522	436	942	Alternative sequence	ID=VSP_042587;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
INTU	Q9ULD6	256	324	276	942	Natural variant	ID=VAR_080710;Note=In SRTD7/20%3B in an SRTD7/20 patient who also carries variant WDR35 L-311. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	364	393	276	942	Natural variant	ID=VAR_080710;Note=In SRTD7/20%3B in an SRTD7/20 patient who also carries variant WDR35 L-311. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	483	501	276	942	Natural variant	ID=VAR_080710;Note=In SRTD7/20%3B in an SRTD7/20 patient who also carries variant WDR35 L-311. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	501	522	276	942	Natural variant	ID=VAR_080710;Note=In SRTD7/20%3B in an SRTD7/20 patient who also carries variant WDR35 L-311. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	364	393	355	942	Natural variant	ID=VAR_080711;Note=In SRTD20%3B loss of subcellular location to cilium basal body%2C when tested in a heterologous system. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	483	501	355	942	Natural variant	ID=VAR_080711;Note=In SRTD20%3B loss of subcellular location to cilium basal body%2C when tested in a heterologous system. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	501	522	355	942	Natural variant	ID=VAR_080711;Note=In SRTD20%3B loss of subcellular location to cilium basal body%2C when tested in a heterologous system. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=PMID:27158779
INTU	Q9ULD6	483	501	500	500	Natural variant	ID=VAR_076783;Note=In SRTD20%3B unknown pathological significance%3B impairs recruitment of IFT43 to the basal body%2C but no effect on subcellular location%2C when tested in a heterologous system. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27158779;Dbxref=dbSNP:rs1360128571,PMID:27158779
IRF6	O14896	222	353	1	467	Chain	ID=PRO_0000154560;Note=Interferon regulatory factor 6
IRF6	O14896	222	353	250	250	Natural variant	ID=VAR_014977;Note=In VWS1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	251	251	Natural variant	ID=VAR_030053;Note=In VWS1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14640121;Dbxref=PMID:14640121
IRF6	O14896	222	353	273	273	Natural variant	ID=VAR_014978;Note=In VWS1. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	274	274	Natural variant	ID=VAR_014979;Note=Common polymorphism%3B 3%25 in European-descended and 22%25 in Asian populations%3B responsible for 12%25 of the genetic contribution to cleft lip or palate%3B tripled the risk of recurrence in families that already had 1 affected child. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12219090,ECO:0000269|PubMed:14702039,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2235371,PMID:12219090,PMID:14702039
IRF6	O14896	222	353	290	296	Natural variant	ID=VAR_014980;Note=In VWS1. FTSKLLD->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	294	294	Natural variant	ID=VAR_014981;Note=In VWS1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	297	297	Natural variant	ID=VAR_014982;Note=In VWS1. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	320	320	Natural variant	ID=VAR_014983;Note=In VWS1. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	321	321	Natural variant	ID=VAR_014984;Note=In VWS1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	325	325	Natural variant	ID=VAR_014985;Note=In VWS1. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	339	339	Natural variant	ID=VAR_059080;Note=In VWS1. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18478600;Dbxref=dbSNP:rs121434231,PMID:18478600
IRF6	O14896	222	353	345	345	Natural variant	ID=VAR_014986;Note=In VWS1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	347	347	Natural variant	ID=VAR_014987;Note=In VWS1. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12219090;Dbxref=PMID:12219090
IRF6	O14896	222	353	349	349	Natural variant	ID=VAR_030054;Note=In VWS1. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17122170;Dbxref=PMID:17122170
ISPD	A4D126	373	417	1	451	Chain	ID=PRO_0000343697;Note=D-ribitol-5-phosphate cytidylyltransferase
ISPD	A4D126	228	263	1	451	Chain	ID=PRO_0000343697;Note=D-ribitol-5-phosphate cytidylyltransferase
ISPD	A4D126	178	228	1	451	Chain	ID=PRO_0000343697;Note=D-ribitol-5-phosphate cytidylyltransferase
ISPD	A4D126	178	228	205	205	Site	Note=Positions substrate for the nucleophilic attack;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q46893
ISPD	A4D126	228	263	263	263	Site	Note=Positions substrate for the nucleophilic attack;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q46893
ISPD	A4D126	228	263	179	228	Alternative sequence	ID=VSP_044044;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ISPD	A4D126	178	228	179	228	Alternative sequence	ID=VSP_044044;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ISPD	A4D126	178	228	205	205	Natural variant	ID=VAR_078949;Note=In MDDGA7. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24120487;Dbxref=dbSNP:rs566179705,PMID:24120487
ISPD	A4D126	178	228	213	213	Natural variant	ID=VAR_069742;Note=In MDDGA7. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23217329;Dbxref=dbSNP:rs397515408,PMID:23217329
ISPD	A4D126	373	417	215	451	Natural variant	ID=VAR_078950;Note=In MDDGC7%3B atypical form presenting with congenital muscular dystrophy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23288328;Dbxref=PMID:23288328
ISPD	A4D126	228	263	215	451	Natural variant	ID=VAR_078950;Note=In MDDGC7%3B atypical form presenting with congenital muscular dystrophy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23288328;Dbxref=PMID:23288328
ISPD	A4D126	178	228	215	451	Natural variant	ID=VAR_078950;Note=In MDDGC7%3B atypical form presenting with congenital muscular dystrophy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23288328;Dbxref=PMID:23288328
ISPD	A4D126	178	228	216	216	Natural variant	ID=VAR_068103;Note=In MDDGA7. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22522421;Dbxref=dbSNP:rs387907160,PMID:22522421
ISPD	A4D126	178	228	226	226	Natural variant	ID=VAR_078951;Note=In MDDGC7%3B atypical form with learning difficulties. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23288328;Dbxref=PMID:23288328
ISPD	A4D126	178	228	226	226	Natural variant	ID=VAR_069743;Note=In MDDGA7. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23217329;Dbxref=PMID:23217329
ISPD	A4D126	228	263	238	238	Natural variant	ID=VAR_069744;Note=In MDDGA7. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23217329;Dbxref=dbSNP:rs397515409,PMID:23217329
ISPD	A4D126	373	417	395	451	Natural variant	ID=VAR_078952;Note=In MDDGC7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23288328;Dbxref=PMID:23288328
ISPD	A4D126	178	228	178	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	178	228	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	178	228	199	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	178	228	205	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	178	228	209	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	228	263	219	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	178	228	219	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	228	263	231	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	228	263	240	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	228	263	253	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	228	263	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	373	417	369	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	373	417	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	373	417	385	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	373	417	394	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	373	417	403	405	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
ISPD	A4D126	373	417	406	414	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CVH
JAG2	Q9Y219	984	1028	24	1238	Chain	ID=PRO_0000007629;Note=Protein jagged-2
JAG2	Q9Y219	903	984	24	1238	Chain	ID=PRO_0000007629;Note=Protein jagged-2
JAG2	Q9Y219	422	460	24	1238	Chain	ID=PRO_0000007629;Note=Protein jagged-2
JAG2	Q9Y219	384	422	24	1238	Chain	ID=PRO_0000007629;Note=Protein jagged-2
JAG2	Q9Y219	346	384	24	1238	Chain	ID=PRO_0000007629;Note=Protein jagged-2
JAG2	Q9Y219	984	1028	27	1080	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG2	Q9Y219	903	984	27	1080	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG2	Q9Y219	422	460	27	1080	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG2	Q9Y219	384	422	27	1080	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG2	Q9Y219	346	384	27	1080	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAG2	Q9Y219	346	384	347	383	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG2	Q9Y219	384	422	385	421	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG2	Q9Y219	422	460	423	459	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
JAG2	Q9Y219	903	984	870	944	Domain	Note=VWFC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
JAG2	Q9Y219	346	384	351	362	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	346	384	356	371	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	346	384	373	382	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	384	422	389	400	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	384	422	394	409	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	384	422	411	420	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	422	460	427	438	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	422	460	432	447	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	422	460	449	458	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JAG2	Q9Y219	422	460	424	461	Alternative sequence	ID=VSP_001395;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662552;Dbxref=PMID:10662552
JAG2	Q9Y219	384	422	384	384	Sequence conflict	Note=L->SA;Ontology_term=ECO:0000305;evidence=ECO:0000305
JAG2	Q9Y219	346	384	384	384	Sequence conflict	Note=L->SA;Ontology_term=ECO:0000305;evidence=ECO:0000305
JAG2	Q9Y219	422	460	424	426	Sequence conflict	Note=ANE->VND;Ontology_term=ECO:0000305;evidence=ECO:0000305
JDP2	Q8WYK2	67	102	1	163	Chain	ID=PRO_0000331130;Note=Jun dimerization protein 2
JDP2	Q8WYK2	67	102	1	163	Chain	ID=PRO_0000331130;Note=Jun dimerization protein 2
JDP2	Q8WYK2	67	102	1	163	Chain	ID=PRO_0000331130;Note=Jun dimerization protein 2
JDP2	Q8WYK2	67	102	72	135	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	72	135	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	72	135	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	74	96	Region	Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	74	96	Region	Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	74	96	Region	Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	100	128	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	100	128	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
JDP2	Q8WYK2	67	102	100	128	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
ITPR3	Q14573	176	209	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	1174	1216	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	1956	1993	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	2408	2443	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	176	209	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	1174	1216	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	1956	1993	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	2408	2443	1	2671	Chain	ID=PRO_0000153928;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 3
ITPR3	Q14573	176	209	1	2202	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	1174	1216	1	2202	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	1956	1993	1	2202	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	176	209	1	2202	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	1174	1216	1	2202	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	1956	1993	1	2202	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	2408	2443	2390	2496	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	2408	2443	2390	2496	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITPR3	Q14573	176	209	174	224	Domain	Note=MIR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131
ITPR3	Q14573	176	209	174	224	Domain	Note=MIR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131
ITPR3	Q14573	2408	2443	2436	2436	Natural variant	ID=VAR_046984;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8081734;Dbxref=dbSNP:rs2229642,PMID:8081734
ITPR3	Q14573	2408	2443	2436	2436	Natural variant	ID=VAR_046984;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8081734;Dbxref=dbSNP:rs2229642,PMID:8081734
AK1	P00568	108	172	1	194	Chain	ID=PRO_0000158910;Note=Adenylate kinase isoenzyme 1
AK1	P00568	69	108	1	194	Chain	ID=PRO_0000158910;Note=Adenylate kinase isoenzyme 1
AK1	P00568	108	172	1	194	Chain	ID=PRO_0000158910;Note=Adenylate kinase isoenzyme 1
AK1	P00568	69	108	1	194	Chain	ID=PRO_0000158910;Note=Adenylate kinase isoenzyme 1
AK1	P00568	69	108	94	97	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	69	108	94	97	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	131	141	Region	Note=LID;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	131	141	Region	Note=LID;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	69	108	101	101	Binding site	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	69	108	101	101	Binding site	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	132	132	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	132	132	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	138	138	Binding site	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	138	138	Binding site	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	149	149	Binding site	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	149	149	Binding site	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03171,ECO:0000269|Ref.11,ECO:0000269|Ref.12
AK1	P00568	108	172	123	123	Natural variant	ID=VAR_034046;Note=E->Q;Dbxref=dbSNP:rs8192462
AK1	P00568	108	172	123	123	Natural variant	ID=VAR_034046;Note=E->Q;Dbxref=dbSNP:rs8192462
AK1	P00568	108	172	128	128	Natural variant	ID=VAR_004021;Note=In HAAKD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2542324;Dbxref=dbSNP:rs104894101,PMID:2542324
AK1	P00568	108	172	128	128	Natural variant	ID=VAR_004021;Note=In HAAKD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2542324;Dbxref=dbSNP:rs104894101,PMID:2542324
AK1	P00568	108	172	140	140	Natural variant	ID=VAR_055339;Note=In HAAKD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12649162;Dbxref=PMID:12649162
AK1	P00568	108	172	140	140	Natural variant	ID=VAR_055339;Note=In HAAKD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12649162;Dbxref=PMID:12649162
AK1	P00568	108	172	164	164	Natural variant	ID=VAR_055340;Note=In HAAKD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9432020;Dbxref=dbSNP:rs137853203,PMID:9432020
AK1	P00568	108	172	164	164	Natural variant	ID=VAR_055340;Note=In HAAKD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9432020;Dbxref=dbSNP:rs137853203,PMID:9432020
AK1	P00568	108	172	127	127	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AK1	P00568	108	172	127	127	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AK1	P00568	69	108	69	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	69	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	90	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	90	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	99	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	99	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	99	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	69	108	99	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	122	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	122	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	139	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	139	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	143	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	143	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	158	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	158	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	170	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
AK1	P00568	108	172	170	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C95
KAT7	O95251	113	193	1	611	Chain	ID=PRO_0000051569;Note=Histone acetyltransferase KAT7
KAT7	O95251	221	251	1	611	Chain	ID=PRO_0000051569;Note=Histone acetyltransferase KAT7
KAT7	O95251	251	284	1	611	Chain	ID=PRO_0000051569;Note=Histone acetyltransferase KAT7
KAT7	O95251	321	385	1	611	Chain	ID=PRO_0000051569;Note=Histone acetyltransferase KAT7
KAT7	O95251	321	385	332	607	Domain	Note=MYST-type HAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01063
KAT7	O95251	113	193	176	219	Zinc finger	Note=CCHHC-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
KAT7	O95251	321	385	365	390	Zinc finger	Note=C2HC MYST-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01063
KAT7	O95251	113	193	124	124	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
KAT7	O95251	113	193	128	128	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SVQ0
KAT7	O95251	113	193	158	158	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KAT7	O95251	113	193	162	162	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
KAT7	O95251	113	193	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
KAT7	O95251	113	193	178	178	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KAT7	O95251	251	284	277	277	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SVQ0
KAT7	O95251	321	385	323	323	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KAT7	O95251	321	385	338	338	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23319590;Dbxref=PMID:23319590
KAT7	O95251	113	193	55	113	Alternative sequence	ID=VSP_042552;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KAT7	O95251	113	193	114	193	Alternative sequence	ID=VSP_042553;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KAT7	O95251	221	251	222	251	Alternative sequence	ID=VSP_042554;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KAT7	O95251	251	284	222	251	Alternative sequence	ID=VSP_042554;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KAT7	O95251	321	385	338	338	Mutagenesis	Note=Decreases ubiquitination. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23319590;Dbxref=PMID:23319590
KAT7	O95251	321	385	371	371	Mutagenesis	Note=No interaction with MCM2 and ORC1. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278932;Dbxref=PMID:11278932
KAT7	O95251	321	385	339	342	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KAT7	O95251	321	385	345	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KAT7	O95251	321	385	357	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KAT7	O95251	321	385	362	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KAT7	O95251	321	385	369	371	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KAT7	O95251	321	385	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KAT7	O95251	321	385	378	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GK9
KCNN2	Q9H2S1	381	418	1	579	Chain	ID=PRO_0000155010;Note=Small conductance calcium-activated potassium channel protein 2
KCNN2	Q9H2S1	381	418	374	394	Transmembrane	Note=Helical%3B Name%3DSegment S6;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNN2	Q9H2S1	381	418	412	488	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
KCNN2	Q9H2S1	381	418	410	412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBX
KCNN2	Q9H2S1	381	418	413	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V02
KCNH1	O95259	103	146	1	989	Chain	ID=PRO_0000053994;Note=Potassium voltage-gated channel subfamily H member 1
KCNH1	O95259	103	146	1	220	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63472
KCNH1	O95259	103	146	93	145	Domain	Note=PAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00141
KCNH1	O95259	103	146	106	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J7E
KCNH1	O95259	103	146	123	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J7E
KCTD9	Q7L273	123	166	1	389	Chain	ID=PRO_0000191293;Note=BTB/POZ domain-containing protein KCTD9
KCTD9	Q7L273	123	166	89	161	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
KCTD9	Q7L273	123	166	125	125	Mutagenesis	Note=Impaired interaction with CUL3. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26334369;Dbxref=PMID:26334369
KCTD9	Q7L273	123	166	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXH
KCTD9	Q7L273	123	166	143	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXH
KCTD9	Q7L273	123	166	146	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXH
KCTD9	Q7L273	123	166	165	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXH
KCNQ3	O43525	348	380	1	872	Chain	ID=PRO_0000054034;Note=Potassium voltage-gated channel subfamily KQT member 3
KCNQ3	O43525	348	380	331	351	Transmembrane	Note=Helical%3B Name%3DSegment S6;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNQ3	O43525	348	380	352	872	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNQ3	O43525	348	380	356	537	Region	Note=Mediates interaction with calmodulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27564677;Dbxref=PMID:27564677
KCNQ3	O43525	348	380	373	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J03
KDELC1	Q6UW63	461	497	20	502	Chain	ID=PRO_0000247163;Note=KDEL motif-containing protein 1
KDELC1	Q6UW63	431	461	20	502	Chain	ID=PRO_0000247163;Note=KDEL motif-containing protein 1
KDELC1	Q6UW63	361	431	20	502	Chain	ID=PRO_0000247163;Note=KDEL motif-containing protein 1
KDELC1	Q6UW63	198	224	20	502	Chain	ID=PRO_0000247163;Note=KDEL motif-containing protein 1
KDELC1	Q6UW63	361	431	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDELC2	Q7Z4H8	431	466	21	507	Chain	ID=PRO_0000247196;Note=KDEL motif-containing protein 2
KDELC2	Q7Z4H8	366	431	21	507	Chain	ID=PRO_0000247196;Note=KDEL motif-containing protein 2
KDELC2	Q7Z4H8	431	466	432	465	Alternative sequence	ID=VSP_019946;Note=In isoform 3. ENDEEAKKIAKEGQLMARDLLQPHRLYCYYYQVL->SFTLSPRLECSGTISTHCNLCLPGSRNFVPQPPE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KDELC2	Q7Z4H8	431	466	466	507	Alternative sequence	ID=VSP_019947;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
L3MBTL4	Q8NA19	547	568	1	623	Chain	ID=PRO_0000337077;Note=Lethal(3)malignant brain tumor-like protein 4
L3MBTL4	Q8NA19	400	457	1	623	Chain	ID=PRO_0000337077;Note=Lethal(3)malignant brain tumor-like protein 4
L3MBTL4	Q8NA19	290	327	1	623	Chain	ID=PRO_0000337077;Note=Lethal(3)malignant brain tumor-like protein 4
L3MBTL4	Q8NA19	290	327	269	364	Repeat	Note=MBT 3
L3MBTL4	Q8NA19	547	568	543	607	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
L3MBTL4	Q8NA19	400	457	370	414	Zinc finger	Note=CCHHC-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
L3MBTL4	Q8NA19	547	568	535	623	Alternative sequence	ID=VSP_033864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LOXL2	Q9Y4K0	434	490	26	774	Chain	ID=PRO_0000018532;Note=Lysyl oxidase homolog 2
LOXL2	Q9Y4K0	434	490	435	544	Domain	Note=SRCR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL2	Q9Y4K0	434	490	455	455	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23319596;Dbxref=PMID:23319596
LOXL2	Q9Y4K0	434	490	464	530	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5ZE3,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:29581294;Dbxref=PMID:29581294
LOXL2	Q9Y4K0	434	490	477	543	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5ZE3,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:29581294;Dbxref=PMID:29581294
LOXL2	Q9Y4K0	434	490	455	455	Mutagenesis	Note=Inhibits secretion. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23319596;Dbxref=PMID:23319596
LOXL2	Q9Y4K0	434	490	434	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ZE3
LOXL2	Q9Y4K0	434	490	445	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ZE3
LOXL2	Q9Y4K0	434	490	457	463	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ZE3
LOXL2	Q9Y4K0	434	490	470	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ZE3
LOXL2	Q9Y4K0	434	490	484	490	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ZE3
LOXL4	Q96JB6	420	476	25	756	Chain	ID=PRO_0000018535;Note=Lysyl oxidase homolog 4
LOXL4	Q96JB6	221	233	25	756	Chain	ID=PRO_0000018535;Note=Lysyl oxidase homolog 4
LOXL4	Q96JB6	221	233	159	287	Domain	Note=SRCR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL4	Q96JB6	420	476	421	529	Domain	Note=SRCR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL4	Q96JB6	221	233	191	276	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL4	Q96JB6	221	233	204	286	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL4	Q96JB6	420	476	450	515	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL4	Q96JB6	420	476	463	528	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
MTX2	O75431	95	126	2	263	Chain	ID=PRO_0000220995;Note=Metaxin-2
MTX2	O75431	139	181	2	263	Chain	ID=PRO_0000220995;Note=Metaxin-2
LRRC47	Q8N1G4	359	398	2	583	Chain	ID=PRO_0000223926;Note=Leucine-rich repeat-containing protein 47
LRBA	P50851	2554	2575	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	2409	2465	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	2358	2409	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	2318	2358	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	2015	2026	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	1487	1523	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	722	752	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	183	215	2	2863	Chain	ID=PRO_0000051068;Note=Lipopolysaccharide-responsive and beige-like anchor protein
LRBA	P50851	2409	2465	2200	2489	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
LRBA	P50851	2358	2409	2200	2489	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
LRBA	P50851	2318	2358	2200	2489	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
LRBA	P50851	1487	1523	1488	1488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
LRBA	P50851	1487	1523	1498	1498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LRBA	P50851	2015	2026	2016	2026	Alternative sequence	ID=VSP_038225;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12160729;Dbxref=PMID:12160729
LRBA	P50851	722	752	750	751	Sequence conflict	Note=LA->RP;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRBA	P50851	2318	2358	2321	2329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2318	2358	2336	2338	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2318	2358	2343	2352	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2358	2409	2362	2365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2358	2409	2368	2371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2400	2412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2358	2409	2400	2412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2414	2417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2420	2427	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2434	2440	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2446	2448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2455	2457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRBA	P50851	2409	2465	2461	2474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T77
LRIG3	Q6UXM1	845	898	25	1119	Chain	ID=PRO_0000014831;Note=Leucine-rich repeats and immunoglobulin-like domains protein 3
LRIG3	Q6UXM1	415	438	25	1119	Chain	ID=PRO_0000014831;Note=Leucine-rich repeats and immunoglobulin-like domains protein 3
LRIG3	Q6UXM1	391	414	25	1119	Chain	ID=PRO_0000014831;Note=Leucine-rich repeats and immunoglobulin-like domains protein 3
LRIG3	Q6UXM1	391	414	387	408	Repeat	Note=LRR 14
LRIG3	Q6UXM1	415	438	411	432	Repeat	Note=LRR 15
LRIG3	Q6UXM1	391	414	411	432	Repeat	Note=LRR 15
LRRC9	Q6ZRR7	181	242	1	1453	Chain	ID=PRO_0000337676;Note=Leucine-rich repeat-containing protein 9
LRRC9	Q6ZRR7	360	403	1	1453	Chain	ID=PRO_0000337676;Note=Leucine-rich repeat-containing protein 9
LRRC9	Q6ZRR7	181	242	166	188	Repeat	Note=LRR 5
LRRC9	Q6ZRR7	181	242	224	248	Repeat	Note=LRR 6
LRRC9	Q6ZRR7	360	403	344	367	Repeat	Note=LRR 8
LRRFIP2	Q9Y608	488	522	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	457	488	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	345	369	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	261	291	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	238	261	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	219	238	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	188	203	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	110	124	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	59	76	1	721	Chain	ID=PRO_0000245246;Note=Leucine-rich repeat flightless-interacting protein 2
LRRFIP2	Q9Y608	345	369	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	261	291	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	238	261	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	219	238	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	188	203	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	110	124	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	59	76	1	370	Region	Note=DVL3-binding
LRRFIP2	Q9Y608	488	522	349	524	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRFIP2	Q9Y608	457	488	349	524	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRFIP2	Q9Y608	345	369	349	524	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRFIP2	Q9Y608	261	291	118	342	Compositional bias	Note=Ser-rich
LRRFIP2	Q9Y608	238	261	118	342	Compositional bias	Note=Ser-rich
LRRFIP2	Q9Y608	219	238	118	342	Compositional bias	Note=Ser-rich
LRRFIP2	Q9Y608	188	203	118	342	Compositional bias	Note=Ser-rich
LRRFIP2	Q9Y608	110	124	118	342	Compositional bias	Note=Ser-rich
LRRFIP2	Q9Y608	188	203	190	190	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220426;Dbxref=PMID:21220426
LRRFIP2	Q9Y608	188	203	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220426;Dbxref=PMID:21220426
LRRFIP2	Q9Y608	488	522	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	457	488	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	345	369	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	261	291	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	238	261	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	219	238	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	188	203	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	110	124	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	59	76	1	621	Alternative sequence	ID=VSP_019674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LRRFIP2	Q9Y608	261	291	60	291	Alternative sequence	ID=VSP_019675;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	238	261	60	291	Alternative sequence	ID=VSP_019675;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	219	238	60	291	Alternative sequence	ID=VSP_019675;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	188	203	60	291	Alternative sequence	ID=VSP_019675;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	110	124	60	291	Alternative sequence	ID=VSP_019675;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	59	76	60	291	Alternative sequence	ID=VSP_019675;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	59	76	60	76	Alternative sequence	ID=VSP_056969;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	110	124	111	124	Alternative sequence	ID=VSP_056970;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	188	203	146	202	Alternative sequence	ID=VSP_056971;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	261	291	220	291	Alternative sequence	ID=VSP_056972;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	238	261	220	291	Alternative sequence	ID=VSP_056972;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	219	238	220	291	Alternative sequence	ID=VSP_056972;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	345	369	346	369	Alternative sequence	ID=VSP_019676;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	488	522	457	521	Alternative sequence	ID=VSP_019677;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	457	488	457	521	Alternative sequence	ID=VSP_019677;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRFIP2	Q9Y608	488	522	489	522	Alternative sequence	ID=VSP_056973;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRFIP2	Q9Y608	188	203	190	190	Mutagenesis	Note=No change in LPS-induced NFKB activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220426;Dbxref=PMID:21220426
LRRFIP2	Q9Y608	188	203	200	200	Mutagenesis	Note=No change in LPS-induced NFKB activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220426;Dbxref=PMID:21220426
LRRFIP2	Q9Y608	188	203	202	202	Mutagenesis	Note=Reduction in LPS-induced NFKB activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220426;Dbxref=PMID:21220426
LRRFIP2	Q9Y608	188	203	202	202	Mutagenesis	Note=No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220426;Dbxref=PMID:21220426
LSM7	Q9UK45	32	56	2	103	Chain	ID=PRO_0000125579;Note=U6 snRNA-associated Sm-like protein LSm7
LAMTOR1	Q6IAA8	63	88	2	161	Chain	ID=PRO_0000274292;Note=Ragulator complex protein LAMTOR1
LAMTOR1	Q6IAA8	63	88	73	73	Natural variant	ID=VAR_030250;Note=S->L;Dbxref=dbSNP:rs1053443
LAMTOR1	Q6IAA8	63	88	69	69	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMTOR1	Q6IAA8	63	88	50	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X6V
LAMTOR1	Q6IAA8	63	88	75	77	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EHR
LAMTOR1	Q6IAA8	63	88	78	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X6V
LUC7L	Q9NQ29	269	324	1	371	Chain	ID=PRO_0000187280;Note=Putative RNA-binding protein Luc7-like 1
LUC7L	Q9NQ29	259	268	1	371	Chain	ID=PRO_0000187280;Note=Putative RNA-binding protein Luc7-like 1
LUC7L	Q9NQ29	170	229	1	371	Chain	ID=PRO_0000187280;Note=Putative RNA-binding protein Luc7-like 1
LUC7L	Q9NQ29	122	170	1	371	Chain	ID=PRO_0000187280;Note=Putative RNA-binding protein Luc7-like 1
LUC7L	Q9NQ29	85	122	1	371	Chain	ID=PRO_0000187280;Note=Putative RNA-binding protein Luc7-like 1
LUC7L	Q9NQ29	52	85	1	371	Chain	ID=PRO_0000187280;Note=Putative RNA-binding protein Luc7-like 1
LUC7L	Q9NQ29	170	229	87	177	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L	Q9NQ29	122	170	87	177	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L	Q9NQ29	85	122	87	177	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L	Q9NQ29	259	268	218	259	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L	Q9NQ29	170	229	218	259	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L	Q9NQ29	269	324	243	362	Compositional bias	Note=Arg/Ser-rich
LUC7L	Q9NQ29	259	268	243	362	Compositional bias	Note=Arg/Ser-rich
LUC7L	Q9NQ29	170	229	171	171	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
LY86	O95711	74	117	21	162	Chain	ID=PRO_0000018614;Note=Lymphocyte antigen 86
LY86	O95711	74	117	21	162	Chain	ID=PRO_0000018614;Note=Lymphocyte antigen 86
LY86	O95711	74	117	96	96	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LY86	O95711	74	117	96	96	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LY86	O95711	74	117	45	154	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21959264;Dbxref=PMID:21959264
LY86	O95711	74	117	45	154	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21959264;Dbxref=PMID:21959264
LY86	O95711	74	117	102	112	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21959264;Dbxref=PMID:21959264
LY86	O95711	74	117	102	112	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21959264;Dbxref=PMID:21959264
LY86	O95711	74	117	93	93	Natural variant	ID=VAR_024531;Note=S->P;Dbxref=dbSNP:rs5743649
LY86	O95711	74	117	93	93	Natural variant	ID=VAR_024531;Note=S->P;Dbxref=dbSNP:rs5743649
LY86	O95711	74	117	79	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B2D
LY86	O95711	74	117	79	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B2D
LY86	O95711	74	117	92	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B2D
LY86	O95711	74	117	92	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B2D
LY86	O95711	74	117	110	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B2D
LY86	O95711	74	117	110	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B2D
LYPD3	O95274	70	127	31	326	Chain	ID=PRO_0000226751;Note=Ly6/PLAUR domain-containing protein 3
LYPD3	O95274	70	127	33	126	Domain	Note=UPAR/Ly6 1
LYPD3	O95274	70	127	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LYST	Q99698	3567	3600	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	3381	3458	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	2871	2933	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	2542	2593	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	2040	2084	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	1928	1974	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	1738	1820	1	3801	Chain	ID=PRO_0000051071;Note=Lysosomal-trafficking regulator
LYST	Q99698	3381	3458	3120	3422	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
LYST	Q99698	3567	3600	3563	3602	Repeat	Note=WD 3
LYST	Q99698	3567	3600	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	3381	3458	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	2871	2933	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	2542	2593	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	2040	2084	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	1928	1974	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	1738	1820	1532	3801	Alternative sequence	ID=VSP_006780;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9215680;Dbxref=PMID:9215680
LYST	Q99698	3567	3600	2002	3801	Alternative sequence	ID=VSP_006782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8717042;Dbxref=PMID:8717042
LYST	Q99698	3381	3458	2002	3801	Alternative sequence	ID=VSP_006782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8717042;Dbxref=PMID:8717042
LYST	Q99698	2871	2933	2002	3801	Alternative sequence	ID=VSP_006782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8717042;Dbxref=PMID:8717042
LYST	Q99698	2542	2593	2002	3801	Alternative sequence	ID=VSP_006782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8717042;Dbxref=PMID:8717042
LYST	Q99698	2040	2084	2002	3801	Alternative sequence	ID=VSP_006782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8717042;Dbxref=PMID:8717042
LYST	Q99698	1928	1974	1949	1949	Natural variant	ID=VAR_053406;Note=Q->H;Dbxref=dbSNP:rs6665568
LYST	Q99698	1928	1974	1929	1930	Sequence conflict	Note=QG->AC;Ontology_term=ECO:0000305;evidence=ECO:0000305
LZTS3	O60299	351	395	1	673	Chain	ID=PRO_0000050760;Note=Leucine zipper putative tumor suppressor 3
LZTS3	O60299	351	395	317	496	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LZTS3	O60299	351	395	351	396	Alternative sequence	ID=VSP_039202;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRRC45	Q96CN5	467	498	1	670	Chain	ID=PRO_0000223923;Note=Leucine-rich repeat-containing protein 45
LRRC45	Q96CN5	467	498	252	645	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD1	Q5T700	24	67	1	205	Chain	ID=PRO_0000299376;Note=Low-density lipoprotein receptor class A domain-containing protein 1
LDLRAD1	Q5T700	24	67	43	63	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD1	Q5T700	24	67	1	66	Alternative sequence	ID=VSP_027617;Note=In isoform 2. MNKVFPQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCT->MQGTRAELSAHSPSRAAGNRRHEQGLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LDLRAD1	Q5T700	24	67	25	114	Alternative sequence	ID=VSP_027618;Note=In isoform 3. AGGGHLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LDLRAD1	Q5T700	24	67	25	67	Alternative sequence	ID=VSP_054532;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRCH2	Q5VUJ6	580	597	1	765	Chain	ID=PRO_0000253482;Note=Leucine-rich repeat and calponin homology domain-containing protein 2
LRCH2	Q5VUJ6	488	509	1	765	Chain	ID=PRO_0000253482;Note=Leucine-rich repeat and calponin homology domain-containing protein 2
LRCH2	Q5VUJ6	580	597	580	596	Alternative sequence	ID=VSP_044969;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRRC20	Q8TCA0	77	133	1	184	Chain	ID=PRO_0000084475;Note=Leucine-rich repeat-containing protein 20
LRRC20	Q8TCA0	27	77	1	184	Chain	ID=PRO_0000084475;Note=Leucine-rich repeat-containing protein 20
LRRC20	Q8TCA0	77	133	1	184	Chain	ID=PRO_0000084475;Note=Leucine-rich repeat-containing protein 20
LRRC20	Q8TCA0	27	77	1	184	Chain	ID=PRO_0000084475;Note=Leucine-rich repeat-containing protein 20
LRRC20	Q8TCA0	27	77	51	72	Repeat	Note=LRR 1
LRRC20	Q8TCA0	27	77	51	72	Repeat	Note=LRR 1
LRRC20	Q8TCA0	77	133	75	96	Repeat	Note=LRR 2
LRRC20	Q8TCA0	27	77	75	96	Repeat	Note=LRR 2
LRRC20	Q8TCA0	77	133	75	96	Repeat	Note=LRR 2
LRRC20	Q8TCA0	27	77	75	96	Repeat	Note=LRR 2
LRRC20	Q8TCA0	77	133	98	120	Repeat	Note=LRR 3
LRRC20	Q8TCA0	77	133	98	120	Repeat	Note=LRR 3
LRRC20	Q8TCA0	77	133	121	141	Repeat	Note=LRR 4
LRRC20	Q8TCA0	77	133	121	141	Repeat	Note=LRR 4
LRRC20	Q8TCA0	77	133	28	77	Alternative sequence	ID=VSP_015933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC20	Q8TCA0	27	77	28	77	Alternative sequence	ID=VSP_015933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC20	Q8TCA0	77	133	28	77	Alternative sequence	ID=VSP_015933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC20	Q8TCA0	27	77	28	77	Alternative sequence	ID=VSP_015933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC20	Q8TCA0	77	133	78	133	Alternative sequence	ID=VSP_015934;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC20	Q8TCA0	77	133	78	133	Alternative sequence	ID=VSP_015934;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LSG1	Q9H089	541	599	1	658	Chain	ID=PRO_0000324553;Note=Large subunit GTPase 1 homolog
LSG1	Q9H089	253	391	1	658	Chain	ID=PRO_0000324553;Note=Large subunit GTPase 1 homolog
LSG1	Q9H089	253	391	164	444	Domain	Note=CP-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01058
LSG1	Q9H089	253	391	267	267	Natural variant	ID=VAR_039827;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11230166,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1675953,PMID:11230166,PMID:14702039,PMID:15489334
MTDH	Q86UE4	189	248	1	582	Chain	ID=PRO_0000084533;Note=Protein LYRIC
MTDH	Q86UE4	248	270	1	582	Chain	ID=PRO_0000084533;Note=Protein LYRIC
MTDH	Q86UE4	349	382	1	582	Chain	ID=PRO_0000084533;Note=Protein LYRIC
MTDH	Q86UE4	424	460	1	582	Chain	ID=PRO_0000084533;Note=Protein LYRIC
MTDH	Q86UE4	460	507	1	582	Chain	ID=PRO_0000084533;Note=Protein LYRIC
MTDH	Q86UE4	189	248	70	582	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTDH	Q86UE4	248	270	70	582	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTDH	Q86UE4	349	382	70	582	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTDH	Q86UE4	424	460	70	582	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTDH	Q86UE4	460	507	70	582	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTDH	Q86UE4	189	248	101	205	Region	Note=Interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16452207;Dbxref=PMID:16452207
MTDH	Q86UE4	349	382	381	443	Region	Note=Lung-homing for mammary tumors;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTDH	Q86UE4	424	460	381	443	Region	Note=Lung-homing for mammary tumors;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTDH	Q86UE4	424	460	441	451	Compositional bias	Note=Poly-Lys
MTDH	Q86UE4	189	248	216	216	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
MTDH	Q86UE4	248	270	251	251	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
MTDH	Q86UE4	248	270	264	264	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80WJ7
MTDH	Q86UE4	349	382	369	369	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
MTDH	Q86UE4	424	460	426	426	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18088087,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MTDH	Q86UE4	424	460	457	457	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1W6
MTDH	Q86UE4	424	460	458	458	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MTDH	Q86UE4	460	507	478	478	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MTDH	Q86UE4	460	507	494	494	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MTDH	Q86UE4	460	507	496	496	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LZTS2	Q9BRK4	136	356	1	669	Chain	ID=PRO_0000182974;Note=Leucine zipper putative tumor suppressor 2
LZTS2	Q9BRK4	136	356	1	669	Chain	ID=PRO_0000182974;Note=Leucine zipper putative tumor suppressor 2
LZTS2	Q9BRK4	136	356	1	332	Region	Note=Required for centrosomal localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
LZTS2	Q9BRK4	136	356	1	332	Region	Note=Required for centrosomal localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
LZTS2	Q9BRK4	136	356	328	649	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03026
LZTS2	Q9BRK4	136	356	328	649	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03026
LZTS2	Q9BRK4	136	356	188	306	Compositional bias	Note=Ser-rich
LZTS2	Q9BRK4	136	356	188	306	Compositional bias	Note=Ser-rich
LZTS2	Q9BRK4	136	356	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YU6
LZTS2	Q9BRK4	136	356	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YU6
LZTS2	Q9BRK4	136	356	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YU6
LZTS2	Q9BRK4	136	356	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YU6
LZTS2	Q9BRK4	136	356	291	291	Natural variant	ID=VAR_036365;Note=In a breast cancer sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
LZTS2	Q9BRK4	136	356	291	291	Natural variant	ID=VAR_036365;Note=In a breast cancer sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
LZTS2	Q9BRK4	136	356	299	299	Natural variant	ID=VAR_018277;Note=R->W;Dbxref=dbSNP:rs2275381
LZTS2	Q9BRK4	136	356	299	299	Natural variant	ID=VAR_018277;Note=R->W;Dbxref=dbSNP:rs2275381
LZTS2	Q9BRK4	136	356	289	289	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
LZTS2	Q9BRK4	136	356	289	289	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MXD4	Q14582	55	64	1	209	Chain	ID=PRO_0000127266;Note=Max dimerization protein 4
MXD4	Q14582	55	64	53	105	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
MAK16	Q9BXY0	213	235	1	300	Chain	ID=PRO_0000203794;Note=Protein MAK16 homolog
MAK16	Q9BXY0	213	235	198	249	Compositional bias	Note=Asp-rich
MAK16	Q9BXY0	213	235	229	229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692
MAK16	Q9BXY0	213	235	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692
MS4A15	Q8N5U1	75	116	1	240	Chain	ID=PRO_0000320577;Note=Membrane-spanning 4-domains subfamily A member 15
MS4A15	Q8N5U1	116	135	1	240	Chain	ID=PRO_0000320577;Note=Membrane-spanning 4-domains subfamily A member 15
MS4A15	Q8N5U1	135	166	1	240	Chain	ID=PRO_0000320577;Note=Membrane-spanning 4-domains subfamily A member 15
MS4A15	Q8N5U1	166	204	1	240	Chain	ID=PRO_0000320577;Note=Membrane-spanning 4-domains subfamily A member 15
MS4A15	Q8N5U1	75	116	73	93	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A15	Q8N5U1	75	116	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A15	Q8N5U1	116	135	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A15	Q8N5U1	135	166	144	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A15	Q8N5U1	166	204	173	193	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A15	Q8N5U1	75	116	1	93	Alternative sequence	ID=VSP_031669;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MS4A15	Q8N5U1	75	116	76	116	Alternative sequence	ID=VSP_053907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MS4A15	Q8N5U1	116	135	76	116	Alternative sequence	ID=VSP_053907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
LEMD3	Q9Y2U8	640	674	2	911	Chain	ID=PRO_0000206149;Note=Inner nuclear membrane protein Man1
LEMD3	Q9Y2U8	640	674	628	648	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LEMD3	Q9Y2U8	640	674	635	640	Compositional bias	Note=Poly-Leu
LEMD3	Q9Y2U8	640	674	659	662	Compositional bias	Note=Poly-Glu
LEMD3	Q9Y2U8	640	674	655	911	Natural variant	ID=VAR_080412;Note=In BOS%3B patient does not show osteopoikilosis. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19438932;Dbxref=PMID:19438932
LEMD3	Q9Y2U8	640	674	659	663	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH0
LEMD3	Q9Y2U8	640	674	664	669	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH0
LEMD3	Q9Y2U8	640	674	670	684	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH0
METAP1D	Q6UB28	66	116	20	335	Chain	ID=PRO_0000314126;Note=Methionine aminopeptidase 1D%2C mitochondrial
MAPKAPK2	P49137	326	353	1	400	Chain	ID=PRO_0000086288;Note=MAP kinase-activated protein kinase 2
MAPKAPK2	P49137	326	353	328	364	Region	Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK2	P49137	326	353	328	328	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK2	P49137	326	353	334	334	Modified residue	Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:8846784;Dbxref=PMID:23186163,PMID:24275569,PMID:8846784
MAPKAPK2	P49137	326	353	353	353	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21131586;Dbxref=PMID:21131586
MAPKAPK2	P49137	326	353	334	334	Mutagenesis	Note=Slight decrease in kinase activity. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14517288,ECO:0000269|PubMed:15014438,ECO:0000269|PubMed:8846784;Dbxref=PMID:14517288,PMID:15014438,PMID:8846784
MAPKAPK2	P49137	326	353	334	334	Mutagenesis	Note=Mimicks phosphorylation state%2C leading to elevated basal kinase activity. T->D%2CE;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14517288,ECO:0000269|PubMed:15014438,ECO:0000269|PubMed:8846784;Dbxref=PMID:14517288,PMID:15014438,PMID:8846784
MAPKAPK2	P49137	326	353	334	334	Mutagenesis	Note=Mimicks phosphorylation state and constitutive protein kinase activity%3B when associated with E-222. T->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14517288,ECO:0000269|PubMed:15014438,ECO:0000269|PubMed:8846784;Dbxref=PMID:14517288,PMID:15014438,PMID:8846784
MAPKAPK2	P49137	326	353	353	353	Mutagenesis	Note=Induces decreased sumoylation and increase in protein kinase activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21131586;Dbxref=PMID:21131586
MAPKAPK2	P49137	326	353	323	326	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M2W
MAPKAPK2	P49137	326	353	328	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M2W
MAPKAPK2	P49137	326	353	335	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M42
MAPKAPK2	P49137	326	353	338	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M2W
MAPKAPK2	P49137	326	353	346	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M2W
MAPKAPK2	P49137	326	353	349	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M2W
MAPKAPK5	Q8IW41	131	161	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
MAPKAPK5	Q8IW41	193	220	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
MAPKAPK5	Q8IW41	407	442	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
MAPKAPK5	Q8IW41	131	161	22	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPKAPK5	Q8IW41	193	220	22	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPKAPK5	Q8IW41	407	442	409	440	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAPKAPK5	Q8IW41	131	161	148	148	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
MAPKAPK5	Q8IW41	193	220	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055
MAPKAPK5	Q8IW41	407	442	407	408	Alternative sequence	ID=VSP_011597;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
MAPKAPK5	Q8IW41	193	220	212	212	Mutagenesis	Note=Mimicks phosphorylation state and displays a slightly higher protein kinase activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055
MARK2	Q7KZI7	112	134	1	788	Chain	ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2
MARK2	Q7KZI7	505	558	1	788	Chain	ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2
MARK2	Q7KZI7	654	668	1	788	Chain	ID=PRO_0000086301;Note=Serine/threonine-protein kinase MARK2
MARK2	Q7KZI7	112	134	53	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MARK2	Q7KZI7	505	558	505	558	Alternative sequence	ID=VSP_051706;Note=In isoform 2%2C isoform 4%2C isoform 5%2C isoform 7%2C isoform 9%2C isoform 10%2C isoform 13%2C isoform 15 and isoform 16. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11433294,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9730619,ECO:0000303|Ref.2;Dbxref=PMID:11433294,PMID:15489334,PMID:9730619
MARK2	Q7KZI7	654	668	645	668	Alternative sequence	ID=VSP_041853;Note=In isoform 15. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARK2	Q7KZI7	654	668	654	668	Alternative sequence	ID=VSP_051708;Note=In isoform 5%2C isoform 11%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11433294,ECO:0000303|PubMed:9730619,ECO:0000303|Ref.2;Dbxref=PMID:11433294,PMID:9730619
MARK2	Q7KZI7	112	134	115	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEC
MARK2	Q7KZI7	112	134	122	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEC
MAST2	Q6P0Q8	326	396	1	1798	Chain	ID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
MAST2	Q6P0Q8	396	430	1	1798	Chain	ID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
MAST2	Q6P0Q8	739	773	1	1798	Chain	ID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
MAST2	Q6P0Q8	773	814	1	1798	Chain	ID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
MAST2	Q6P0Q8	739	773	512	785	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAST2	Q6P0Q8	773	814	512	785	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAST2	Q6P0Q8	773	814	786	854	Domain	Note=AGC-kinase C-terminal
MAST2	Q6P0Q8	326	396	327	396	Alternative sequence	ID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAST2	Q6P0Q8	396	430	327	396	Alternative sequence	ID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAST2	Q6P0Q8	326	396	388	388	Natural variant	ID=VAR_040773;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs11211247,PMID:12117771,PMID:17344846
LAMC2	Q13753	26	89	22	1193	Chain	ID=PRO_0000017077;Note=Laminin subunit gamma-2
LAMC2	Q13753	489	571	22	1193	Chain	ID=PRO_0000017077;Note=Laminin subunit gamma-2
LAMC2	Q13753	867	918	22	1193	Chain	ID=PRO_0000017077;Note=Laminin subunit gamma-2
LAMC2	Q13753	26	89	28	83	Domain	Note=Laminin EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	26	89	84	130	Domain	Note=Laminin EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	462	516	Domain	Note=Laminin EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	517	572	Domain	Note=Laminin EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	867	918	603	1193	Region	Note=Domain II and I
LAMC2	Q13753	867	918	811	1076	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMC2	Q13753	26	89	28	37	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	26	89	30	53	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	26	89	56	65	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	26	89	68	81	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	26	89	84	96	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	26	89	86	102	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	484	493	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	496	514	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	517	531	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	519	538	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	541	550	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	553	570	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC2	Q13753	489	571	521	521	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMC2	Q13753	489	571	521	521	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMC2	Q13753	867	918	883	883	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMC2	Q13753	867	918	883	883	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMC1	P11047	1189	1234	34	1609	Chain	ID=PRO_0000017074;Note=Laminin subunit gamma-1
LAMC1	P11047	1189	1234	1030	1609	Region	Note=Domain II and I
LAMC1	P11047	1189	1234	1038	1609	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMC1	P11047	1189	1234	1205	1205	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMC1	P11047	1189	1234	1223	1223	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
LDB1	Q86U70	43	57	2	411	Chain	ID=PRO_0000084384;Note=LIM domain-binding protein 1
LDHC	P07864	81	139	1	332	Chain	ID=PRO_0000168479;Note=L-lactate dehydrogenase C chain
LDHC	P07864	81	139	1	332	Chain	ID=PRO_0000168479;Note=L-lactate dehydrogenase C chain
LDHC	P07864	81	139	99	99	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
LDHC	P07864	81	139	99	99	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
LDHC	P07864	81	139	106	106	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
LDHC	P07864	81	139	106	106	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
LDHC	P07864	81	139	138	138	Binding site	Note=NAD or substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
LDHC	P07864	81	139	138	138	Binding site	Note=NAD or substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
LDHC	P07864	81	139	82	82	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LDHC	P07864	81	139	82	82	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LDHC	P07864	81	139	119	119	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
LDHC	P07864	81	139	119	119	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
LCP2	Q13094	415	441	1	533	Chain	ID=PRO_0000084368;Note=Lymphocyte cytosolic protein 2
LCP2	Q13094	229	257	1	533	Chain	ID=PRO_0000084368;Note=Lymphocyte cytosolic protein 2
LCP2	Q13094	415	441	422	530	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
LCP2	Q13094	229	257	237	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H3H
MT3	P25713	10	32	1	68	Chain	ID=PRO_0000197250;Note=Metallothionein-3
MT3	P25713	10	32	1	30	Region	Note=Beta
MT3	P25713	10	32	31	68	Region	Note=Alpha
MT3	P25713	10	32	14	14	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MT3	P25713	10	32	16	16	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MT3	P25713	10	32	20	20	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MT3	P25713	10	32	22	22	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MT3	P25713	10	32	25	25	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MT3	P25713	10	32	27	27	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MT3	P25713	10	32	30	30	Metal binding	Note=Divalent metal cation%3B cluster B;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTA3	Q9BTC8	234	297	1	594	Chain	ID=PRO_0000083498;Note=Metastasis-associated protein MTA3
MTA3	Q9BTC8	234	297	148	259	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
MTA3	Q9BTC8	234	297	266	318	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
MTBP	Q96DY7	482	536	1	904	Chain	ID=PRO_0000323745;Note=Mdm2-binding protein
MTBP	Q96DY7	628	659	1	904	Chain	ID=PRO_0000323745;Note=Mdm2-binding protein
MTBP	Q96DY7	482	536	521	904	Region	Note=Interaction with MDM2;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTBP	Q96DY7	628	659	521	904	Region	Note=Interaction with MDM2;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTBP	Q96DY7	628	659	639	639	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
MTBP	Q96DY7	482	536	330	904	Alternative sequence	ID=VSP_056109;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTBP	Q96DY7	628	659	330	904	Alternative sequence	ID=VSP_056109;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTFR1	Q15390	22	55	1	48	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTFR1	Q15390	22	55	49	333	Chain	ID=PRO_0000096622;Note=Mitochondrial fission regulator 1
MTFR1	Q15390	22	55	23	55	Alternative sequence	ID=VSP_046765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LIPG	Q9Y5X9	93	153	21	500	Chain	ID=PRO_0000017797;Note=Endothelial lipase
LIPG	Q9Y5X9	190	264	21	500	Chain	ID=PRO_0000017797;Note=Endothelial lipase
LIPG	Q9Y5X9	93	153	118	121	Compositional bias	Note=Poly-Val
LIPG	Q9Y5X9	190	264	193	193	Active site	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10037
LIPG	Q9Y5X9	93	153	136	136	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPG	Q9Y5X9	190	264	252	272	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
LIPG	Q9Y5X9	93	153	96	96	Natural variant	ID=VAR_017027;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12966036;Dbxref=dbSNP:rs150879681,PMID:12966036
LIPG	Q9Y5X9	93	153	111	111	Natural variant	ID=VAR_017028;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12966036;Dbxref=dbSNP:rs2000813,PMID:12966036
LMBRD1	Q9NUN5	396	446	1	540	Chain	ID=PRO_0000260515;Note=Probable lysosomal cobalamin transporter
LMBRD1	Q9NUN5	396	446	386	408	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBRD1	Q9NUN5	396	446	409	429	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBRD1	Q9NUN5	396	446	430	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBRD1	Q9NUN5	396	446	393	540	Alternative sequence	ID=VSP_036540;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
L3MBTL2	Q969R5	417	452	1	705	Chain	ID=PRO_0000084448;Note=Lethal(3)malignant brain tumor-like protein 2
L3MBTL2	Q969R5	629	668	1	705	Chain	ID=PRO_0000084448;Note=Lethal(3)malignant brain tumor-like protein 2
L3MBTL2	Q969R5	417	452	397	500	Repeat	Note=MBT 3
L3MBTL2	Q969R5	629	668	647	647	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
L3MBTL2	Q969R5	629	668	659	659	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
L3MBTL2	Q969R5	629	668	615	705	Alternative sequence	ID=VSP_003905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11682070;Dbxref=PMID:11682070
L3MBTL2	Q969R5	629	668	618	705	Alternative sequence	ID=VSP_003907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
L3MBTL2	Q969R5	417	452	420	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F70
L3MBTL2	Q969R5	417	452	433	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F70
L3MBTL2	Q969R5	417	452	441	453	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F70
LMNB2	Q03252	530	570	1	617	Chain	ID=PRO_0000063820;Note=Lamin-B2
LMNB2	Q03252	530	570	462	579	Domain	Note=LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01187
LMNB2	Q03252	530	570	401	620	Region	Note=Tail
LMNB2	Q03252	530	570	528	533	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLL
LMNB2	Q03252	530	570	534	536	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLL
LMNB2	Q03252	530	570	542	544	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLL
LMNB2	Q03252	530	570	545	548	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLL
LMNB2	Q03252	530	570	552	555	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLL
LMNB2	Q03252	530	570	558	565	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLL
LOXL3	P58215	416	472	26	753	Chain	ID=PRO_0000018533;Note=Lysyl oxidase homolog 3
LOXL3	P58215	416	472	417	525	Domain	Note=SRCR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL3	P58215	416	472	446	511	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL3	P58215	416	472	459	524	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LOXL3	P58215	416	472	446	446	Mutagenesis	Note=Impaired ability to mediate deacetylation of STAT3%3B when associated with A-376 and A-492. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
LOXL3	P58215	416	472	459	459	Mutagenesis	Note=Impaired ability to mediate deacetylation of STAT3%3B when associated with A-83%3B A-214 and A-345. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
LPCAT4	Q643R3	381	414	1	524	Chain	ID=PRO_0000247054;Note=Lysophospholipid acyltransferase LPCAT4
LPIN3	Q9BQK8	64	96	1	851	Chain	ID=PRO_0000209883;Note=Phosphatidate phosphatase LPIN3
LPIN3	Q9BQK8	509	540	1	851	Chain	ID=PRO_0000209883;Note=Phosphatidate phosphatase LPIN3
LPIN3	Q9BQK8	680	730	1	851	Chain	ID=PRO_0000209883;Note=Phosphatidate phosphatase LPIN3
LPIN3	Q9BQK8	64	96	1	108	Region	Note=N-LIP
LPIN3	Q9BQK8	680	730	590	792	Region	Note=C-LIP
LRRC31	Q6UY01	386	442	1	552	Chain	ID=PRO_0000229922;Note=Leucine-rich repeat-containing protein 31
LRRC31	Q6UY01	274	330	1	552	Chain	ID=PRO_0000229922;Note=Leucine-rich repeat-containing protein 31
LRRC31	Q6UY01	106	162	1	552	Chain	ID=PRO_0000229922;Note=Leucine-rich repeat-containing protein 31
LRRC31	Q6UY01	274	330	255	275	Repeat	Note=LRR 2
LRRC31	Q6UY01	274	330	283	293	Repeat	Note=LRR 3
LRRC31	Q6UY01	274	330	311	331	Repeat	Note=LRR 4
LRRC31	Q6UY01	386	442	367	387	Repeat	Note=LRR 6
LRRC31	Q6UY01	386	442	395	415	Repeat	Note=LRR 7
LRRC31	Q6UY01	386	442	423	443	Repeat	Note=LRR 8
LRRC31	Q6UY01	106	162	107	162	Alternative sequence	ID=VSP_017797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC31	Q6UY01	386	442	347	552	Alternative sequence	ID=VSP_017799;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC31	Q6UY01	274	330	322	322	Natural variant	ID=VAR_034085;Note=L->F;Dbxref=dbSNP:rs35923425
LRRC31	Q6UY01	274	330	324	324	Natural variant	ID=VAR_051111;Note=A->E;Dbxref=dbSNP:rs3732452
LRRC31	Q6UY01	386	442	412	412	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP2	P98164	4540	4576	26	4655	Chain	ID=PRO_0000017321;Note=Low-density lipoprotein receptor-related protein 2
LRP2	P98164	3671	3714	26	4655	Chain	ID=PRO_0000017321;Note=Low-density lipoprotein receptor-related protein 2
LRP2	P98164	969	1063	26	4655	Chain	ID=PRO_0000017321;Note=Low-density lipoprotein receptor-related protein 2
LRP2	P98164	705	773	26	4655	Chain	ID=PRO_0000017321;Note=Low-density lipoprotein receptor-related protein 2
LRP2	P98164	179	217	26	4655	Chain	ID=PRO_0000017321;Note=Low-density lipoprotein receptor-related protein 2
LRP2	P98164	3671	3714	26	4423	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP2	P98164	969	1063	26	4423	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP2	P98164	705	773	26	4423	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP2	P98164	179	217	26	4423	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP2	P98164	4540	4576	4447	4655	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP2	P98164	179	217	146	180	Domain	Note=LDL-receptor class A 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	179	217	182	218	Domain	Note=LDL-receptor class A 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	705	773	753	795	Repeat	Note=LDL-receptor class B 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00461
LRP2	P98164	969	1063	1025	1061	Domain	Note=LDL-receptor class A 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	3671	3714	3634	3672	Domain	Note=LDL-receptor class A 29;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	3671	3714	3677	3715	Domain	Note=LDL-receptor class A 30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	4540	4576	4569	4569	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2ARV4
LRP2	P98164	3671	3714	3680	3680	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP2	P98164	179	217	164	179	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	179	217	183	195	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	179	217	190	208	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	179	217	202	217	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	969	1063	1026	1038	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	969	1063	1033	1051	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	969	1063	1045	1060	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	3671	3714	3654	3671	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	3671	3714	3678	3692	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	3671	3714	3686	3705	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP2	P98164	3671	3714	3699	3714	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LUZP2	Q86TE4	111	132	20	346	Chain	ID=PRO_0000315274;Note=Leucine zipper protein 2
LUZP2	Q86TE4	132	153	20	346	Chain	ID=PRO_0000315274;Note=Leucine zipper protein 2
LUZP2	Q86TE4	255	286	20	346	Chain	ID=PRO_0000315274;Note=Leucine zipper protein 2
LUZP2	Q86TE4	111	132	16	211	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUZP2	Q86TE4	132	153	16	211	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUZP2	Q86TE4	132	153	133	133	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LUZP2	Q86TE4	255	286	264	264	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LUZP2	Q86TE4	132	153	133	159	Alternative sequence	ID=VSP_030520;Note=In isoform 2. NKSLKNKLLSGNKLCGIHAEESKKIQA->DSRKRPRDLQWKIVSMRTMSIYLLMYL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
LUZP2	Q86TE4	132	153	133	136	Alternative sequence	ID=VSP_030521;Note=In isoform 3. NKSL->VIQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LUZP2	Q86TE4	132	153	137	346	Alternative sequence	ID=VSP_030522;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LUZP2	Q86TE4	255	286	137	346	Alternative sequence	ID=VSP_030522;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LUZP2	Q86TE4	255	286	160	346	Alternative sequence	ID=VSP_030523;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SELP	P16109	762	802	42	830	Chain	ID=PRO_0000017498;Note=P-selectin
SELP	P16109	568	630	42	830	Chain	ID=PRO_0000017498;Note=P-selectin
SELP	P16109	506	568	42	830	Chain	ID=PRO_0000017498;Note=P-selectin
SELP	P16109	382	444	42	830	Chain	ID=PRO_0000017498;Note=P-selectin
SELP	P16109	320	382	42	830	Chain	ID=PRO_0000017498;Note=P-selectin
SELP	P16109	762	802	42	771	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	568	630	42	771	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	506	568	42	771	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	382	444	42	771	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	320	382	42	771	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	762	802	772	795	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	762	802	796	830	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	320	382	260	321	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	382	444	322	383	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	320	382	322	383	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	382	444	384	445	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	506	568	446	507	Domain	Note=Sushi 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	568	630	508	569	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	506	568	508	569	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	568	630	570	631	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	762	802	702	763	Domain	Note=Sushi 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELP	P16109	382	444	411	411	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	506	568	518	518	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELP	P16109	320	382	324	368	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	320	382	354	381	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	382	444	386	430	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	382	444	416	443	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	506	568	510	554	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	506	568	540	567	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	568	630	572	616	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	568	630	602	629	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELP	P16109	320	382	331	331	Natural variant	ID=VAR_004192;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:9668170,ECO:0000269|Ref.2;Dbxref=dbSNP:rs6131,PMID:10391209,PMID:9668170
SELP	P16109	320	382	365	365	Natural variant	ID=VAR_013912;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs6134,PMID:10391209
SELP	P16109	382	444	385	385	Natural variant	ID=VAR_019384;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3917742
SELP	P16109	506	568	542	542	Natural variant	ID=VAR_019385;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3917769
SELP	P16109	568	630	603	603	Natural variant	ID=VAR_004193;Note=D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:2466574,ECO:0000269|PubMed:9668170,ECO:0000269|Ref.2;Dbxref=dbSNP:rs6127,PMID:10391209,PMID:2466574,PMID:9668170
SELP	P16109	568	630	619	619	Natural variant	ID=VAR_019386;Note=S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs2228672
LYAR	Q9NX58	277	306	1	379	Chain	ID=PRO_0000084528;Note=Cell growth-regulating nucleolar protein
LYAR	Q9NX58	79	115	1	379	Chain	ID=PRO_0000084528;Note=Cell growth-regulating nucleolar protein
LYAR	Q9NX58	277	306	1	379	Chain	ID=PRO_0000084528;Note=Cell growth-regulating nucleolar protein
LYAR	Q9NX58	79	115	1	379	Chain	ID=PRO_0000084528;Note=Cell growth-regulating nucleolar protein
LYAR	Q9NX58	277	306	168	379	Compositional bias	Note=Lys-rich
LYAR	Q9NX58	277	306	168	379	Compositional bias	Note=Lys-rich
ALOX15B	O15296	400	429	1	676	Chain	ID=PRO_0000220700;Note=Arachidonate 15-lipoxygenase B
ALOX15B	O15296	400	429	125	676	Domain	Note=Lipoxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726
ALOX15B	O15296	400	429	401	429	Alternative sequence	ID=VSP_003142;Note=In isoform B and isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11839751;Dbxref=PMID:11839751
ALOX15B	O15296	400	429	397	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE
ALOX15B	O15296	400	429	403	406	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE
ALOX15B	O15296	400	429	409	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE
ALOX15B	O15296	400	429	426	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE
LXN	Q9BS40	169	190	1	222	Chain	ID=PRO_0000191343;Note=Latexin
LXN	Q9BS40	169	190	118	222	Region	Note=Cystatin-like fold 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
LXN	Q9BS40	169	190	158	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
LXN	Q9BS40	169	190	172	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
LXN	Q9BS40	169	190	176	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
LXN	Q9BS40	169	190	187	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
LYPLA2	O95372	157	215	1	231	Chain	ID=PRO_0000102271;Note=Acyl-protein thioesterase 2
LYPLA2	O95372	157	215	176	176	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O75608
LYPLA2	O95372	157	215	210	210	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O75608
LYPLA2	O95372	157	215	155	158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	161	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	167	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	181	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	197	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	200	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYPLA2	O95372	157	215	214	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYN
LYNX1	P0DP58	17	52	1	20	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
LYNX1	P0DP58	17	52	21	91	Chain	ID=PRO_0000036154;Note=Ly-6/neurotoxin-like protein 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LYNX1	P0DP58	17	52	21	107	Domain	Note=UPAR/Ly6;Ontology_term=ECO:0000255;evidence=ECO:0000255
LYNX1	P0DP58	17	52	23	46	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2L03,ECO:0000269|PubMed:21252236;Dbxref=PMID:21252236
LYNX1	P0DP58	17	52	26	33	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2L03,ECO:0000269|PubMed:21252236;Dbxref=PMID:21252236
LYNX1	P0DP58	17	52	39	64	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2L03,ECO:0000269|PubMed:21252236;Dbxref=PMID:21252236
LYNX1	P0DP58	17	52	52	116	Alternative sequence	ID=VSP_058978;Note=In isoform 2. YYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGTGLATPATLALAPILLATLWGLL->SAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRVLSNTEDLPLVTKMCHIGCPDIPSLGLGPYVSIACCQTSLCNHD
LYNX1	P0DP58	17	52	22	24	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L03
LYNX1	P0DP58	17	52	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L03
LYNX1	P0DP58	17	52	36	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L03
LYNX1	P0DP58	17	52	45	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L03
LYVE1	Q9Y5Y7	132	234	20	322	Chain	ID=PRO_0000252133;Note=Lymphatic vessel endothelial hyaluronic acid receptor 1
LYVE1	Q9Y5Y7	132	234	20	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LYVE1	Q9Y5Y7	132	234	214	214	Natural variant	ID=VAR_027764;Note=T->I;Dbxref=dbSNP:rs16907980
LYVE1	Q9Y5Y7	132	234	139	139	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LZIC	Q8WZA0	112	144	1	190	Chain	ID=PRO_0000263691;Note=Protein LZIC
LZIC	Q8WZA0	79	112	1	190	Chain	ID=PRO_0000263691;Note=Protein LZIC
LZIC	Q8WZA0	112	144	1	190	Chain	ID=PRO_0000263691;Note=Protein LZIC
LZIC	Q8WZA0	79	112	1	190	Chain	ID=PRO_0000263691;Note=Protein LZIC
LZIC	Q8WZA0	112	144	1	190	Chain	ID=PRO_0000263691;Note=Protein LZIC
LZIC	Q8WZA0	79	112	1	190	Chain	ID=PRO_0000263691;Note=Protein LZIC
LZIC	Q8WZA0	79	112	104	104	Natural variant	ID=VAR_053371;Note=G->D;Dbxref=dbSNP:rs2304778
LZIC	Q8WZA0	79	112	104	104	Natural variant	ID=VAR_053371;Note=G->D;Dbxref=dbSNP:rs2304778
LZIC	Q8WZA0	79	112	104	104	Natural variant	ID=VAR_053371;Note=G->D;Dbxref=dbSNP:rs2304778
LZTS1	Q9Y250	115	383	2	596	Chain	ID=PRO_0000182971;Note=Leucine zipper putative tumor suppressor 1
LZTS1	Q9Y250	115	383	2	596	Chain	ID=PRO_0000182971;Note=Leucine zipper putative tumor suppressor 1
LZTS1	Q9Y250	115	383	256	374	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LZTS1	Q9Y250	115	383	256	374	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LZTS1	Q9Y250	115	383	77	596	Alternative sequence	ID=VSP_009941;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10097140;Dbxref=PMID:10097140
LZTS1	Q9Y250	115	383	77	596	Alternative sequence	ID=VSP_009941;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10097140;Dbxref=PMID:10097140
LZTS1	Q9Y250	115	383	186	571	Alternative sequence	ID=VSP_009942;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10097140;Dbxref=PMID:10097140
LZTS1	Q9Y250	115	383	186	571	Alternative sequence	ID=VSP_009942;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10097140;Dbxref=PMID:10097140
LZTS1	Q9Y250	115	383	119	119	Natural variant	ID=VAR_018275;Note=Found in an esophageal cancer sample%3B esophageal squamous cell carcinoma%3B somatic mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10097140;Dbxref=dbSNP:rs119473032,PMID:10097140
LZTS1	Q9Y250	115	383	119	119	Natural variant	ID=VAR_018275;Note=Found in an esophageal cancer sample%3B esophageal squamous cell carcinoma%3B somatic mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10097140;Dbxref=dbSNP:rs119473032,PMID:10097140
MAP3K2	Q9Y2U5	88	126	1	619	Chain	ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2
MAP3K2	Q9Y2U5	88	126	1	619	Chain	ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2
MAP3K2	Q9Y2U5	88	126	43	122	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
MAP3K2	Q9Y2U5	88	126	43	122	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
MAP3K2	Q9Y2U5	88	126	110	110	Natural variant	ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846
MAP3K2	Q9Y2U5	88	126	110	110	Natural variant	ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846
MAP3K2	Q9Y2U5	88	126	112	112	Natural variant	ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MAP3K2	Q9Y2U5	88	126	112	112	Natural variant	ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MAP3K2	Q9Y2U5	88	126	103	103	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K2	Q9Y2U5	88	126	103	103	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K2	Q9Y2U5	88	126	103	103	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K2	Q9Y2U5	88	126	103	103	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K2	Q9Y2U5	88	126	89	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT
MAP3K2	Q9Y2U5	88	126	89	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT
MAP3K2	Q9Y2U5	88	126	96	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT
MAP3K2	Q9Y2U5	88	126	96	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT
MAP3K2	Q9Y2U5	88	126	114	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT
MAP3K2	Q9Y2U5	88	126	114	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT
MAN2B2	Q9Y2E5	605	668	24	1009	Chain	ID=PRO_0000012077;Note=Epididymis-specific alpha-mannosidase
MAN2B2	Q9Y2E5	753	790	24	1009	Chain	ID=PRO_0000012077;Note=Epididymis-specific alpha-mannosidase
MAN2B2	Q9Y2E5	605	668	608	608	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAP4K4	O95819	19	41	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	41	60	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	411	465	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	465	494	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	568	622	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	878	935	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	983	1028	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	1062	1112	2	1239	Chain	ID=PRO_0000086280;Note=Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4	O95819	19	41	25	289	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K4	O95819	41	60	25	289	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K4	O95819	878	935	926	1213	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MAP4K4	O95819	983	1028	926	1213	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MAP4K4	O95819	1062	1112	926	1213	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MAP4K4	O95819	19	41	31	39	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K4	O95819	878	935	858	1212	Region	Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141
MAP4K4	O95819	983	1028	858	1212	Region	Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141
MAP4K4	O95819	1062	1112	858	1212	Region	Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966141;Dbxref=PMID:14966141
MAP4K4	O95819	41	60	54	54	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K4	O95819	878	935	900	900	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
MAP4K4	O95819	878	935	913	913	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4K4	O95819	568	622	569	622	Alternative sequence	ID=VSP_007055;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9890973;Dbxref=PMID:9890973
MAP4K4	O95819	1062	1112	1112	1112	Alternative sequence	ID=VSP_007058;Note=In isoform 4 and isoform 5. H->HVRKNPHSM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9890973;Dbxref=PMID:9890973
MAP4K4	O95819	19	41	22	24	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y
MAP4K4	O95819	19	41	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y
MAP4K4	O95819	19	41	35	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y
MAP4K4	O95819	41	60	35	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y
MAP4K4	O95819	41	60	45	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y
MAP4K4	O95819	41	60	50	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U3Y
MAP4K4	O95819	41	60	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZP5
MAF1	Q9H063	167	206	1	256	Chain	ID=PRO_0000213973;Note=Repressor of RNA polymerase III transcription MAF1 homolog
MAF1	Q9H063	207	249	1	256	Chain	ID=PRO_0000213973;Note=Repressor of RNA polymerase III transcription MAF1 homolog
MAF1	Q9H063	167	206	1	256	Chain	ID=PRO_0000213973;Note=Repressor of RNA polymerase III transcription MAF1 homolog
MAF1	Q9H063	207	249	1	256	Chain	ID=PRO_0000213973;Note=Repressor of RNA polymerase III transcription MAF1 homolog
MAF1	Q9H063	207	249	212	212	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20516213;Dbxref=PMID:20516213
MAF1	Q9H063	207	249	212	212	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20516213;Dbxref=PMID:20516213
MAF1	Q9H063	207	249	214	214	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:20516213;Dbxref=PMID:23186163,PMID:20516213
MAF1	Q9H063	207	249	214	214	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:20516213;Dbxref=PMID:23186163,PMID:20516213
MAF1	Q9H063	207	249	236	236	Natural variant	ID=VAR_060408;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11230166,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2,ECO:0000269|Ref.4;Dbxref=dbSNP:rs11546144,PMID:11230166,PMID:15489334
MAF1	Q9H063	207	249	236	236	Natural variant	ID=VAR_060408;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11230166,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2,ECO:0000269|Ref.4;Dbxref=dbSNP:rs11546144,PMID:11230166,PMID:15489334
MAF1	Q9H063	167	206	164	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	164	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	183	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	183	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	193	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	193	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	197	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MAF1	Q9H063	167	206	197	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NR5
MXD3	Q9BW11	59	68	1	206	Chain	ID=PRO_0000253707;Note=Max dimerization protein 3
MXD3	Q9BW11	59	68	1	206	Chain	ID=PRO_0000253707;Note=Max dimerization protein 3
MXD3	Q9BW11	59	68	57	109	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
MXD3	Q9BW11	59	68	57	109	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
MXD3	Q9BW11	59	68	60	68	Alternative sequence	ID=VSP_021109;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MXD3	Q9BW11	59	68	60	68	Alternative sequence	ID=VSP_021109;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MS4A12	Q9NXJ0	92	138	1	267	Chain	ID=PRO_0000158648;Note=Membrane-spanning 4-domains subfamily A member 12
MS4A12	Q9NXJ0	92	138	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A12	Q9NXJ0	92	138	113	120	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A12	Q9NXJ0	92	138	121	141	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A12	Q9NXJ0	92	138	93	138	Alternative sequence	ID=VSP_044899;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16344560;Dbxref=PMID:16344560
LIPH	Q8WWY8	365	422	19	451	Chain	ID=PRO_0000273321;Note=Lipase member H
LIPH	Q8WWY8	295	327	19	451	Chain	ID=PRO_0000273321;Note=Lipase member H
LIPH	Q8WWY8	239	295	19	451	Chain	ID=PRO_0000273321;Note=Lipase member H
LIPH	Q8WWY8	209	239	19	451	Chain	ID=PRO_0000273321;Note=Lipase member H
LIPH	Q8WWY8	175	209	19	451	Chain	ID=PRO_0000273321;Note=Lipase member H
LIPH	Q8WWY8	175	209	178	178	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
LIPH	Q8WWY8	239	295	248	248	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
LIPH	Q8WWY8	239	295	233	246	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LIPH	Q8WWY8	209	239	233	246	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LIPH	Q8WWY8	239	295	270	281	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LIPH	Q8WWY8	239	295	284	292	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LIPH	Q8WWY8	175	209	172	205	Natural variant	ID=VAR_030125;Note=In HYPT7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17095700;Dbxref=PMID:17095700
PNLIPRP1	P54315	68	110	18	467	Chain	ID=PRO_0000017790;Note=Inactive pancreatic lipase-related protein 1
PNLIPRP1	P54315	110	155	18	467	Chain	ID=PRO_0000017790;Note=Inactive pancreatic lipase-related protein 1
PNLIPRP1	P54315	391	446	18	467	Chain	ID=PRO_0000017790;Note=Inactive pancreatic lipase-related protein 1
PNLIPRP1	P54315	68	110	18	467	Chain	ID=PRO_0000017790;Note=Inactive pancreatic lipase-related protein 1
PNLIPRP1	P54315	110	155	18	467	Chain	ID=PRO_0000017790;Note=Inactive pancreatic lipase-related protein 1
PNLIPRP1	P54315	391	446	18	467	Chain	ID=PRO_0000017790;Note=Inactive pancreatic lipase-related protein 1
PNLIPRP1	P54315	391	446	356	467	Domain	Note=PLAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
PNLIPRP1	P54315	391	446	356	467	Domain	Note=PLAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
PNLIPRP1	P54315	68	110	109	120	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00152,ECO:0000269|Ref.5
PNLIPRP1	P54315	110	155	109	120	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00152,ECO:0000269|Ref.5
PNLIPRP1	P54315	68	110	109	120	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00152,ECO:0000269|Ref.5
PNLIPRP1	P54315	110	155	109	120	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00152,ECO:0000269|Ref.5
PNLIPRP1	P54315	110	155	111	186	Alternative sequence	ID=VSP_014097;Note=In isoform 2. KLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPG->VGASSDPCGQLRPTLLLTSLHHFMHSRNLYILGNFMQLKCFSSQKLKCLSMFPHYICTLKQPHLLLEKYSYYLISG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PNLIPRP1	P54315	110	155	111	186	Alternative sequence	ID=VSP_014097;Note=In isoform 2. KLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPG->VGASSDPCGQLRPTLLLTSLHHFMHSRNLYILGNFMQLKCFSSQKLKCLSMFPHYICTLKQPHLLLEKYSYYLISG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PNLIPRP1	P54315	110	155	111	117	Alternative sequence	ID=VSP_014098;Note=In isoform 3. KLFEVEE->PGASPRA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PNLIPRP1	P54315	110	155	111	117	Alternative sequence	ID=VSP_014098;Note=In isoform 3. KLFEVEE->PGASPRA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PNLIPRP1	P54315	110	155	118	467	Alternative sequence	ID=VSP_014099;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PNLIPRP1	P54315	391	446	118	467	Alternative sequence	ID=VSP_014099;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PNLIPRP1	P54315	110	155	118	467	Alternative sequence	ID=VSP_014099;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PNLIPRP1	P54315	391	446	118	467	Alternative sequence	ID=VSP_014099;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PNLIPRP1	P54315	391	446	187	467	Alternative sequence	ID=VSP_014100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PNLIPRP1	P54315	391	446	187	467	Alternative sequence	ID=VSP_014100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PNLIPRP1	P54315	110	155	129	129	Natural variant	ID=VAR_036379;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
PNLIPRP1	P54315	110	155	129	129	Natural variant	ID=VAR_036379;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
PNLIPRP1	P54315	391	446	414	414	Natural variant	ID=VAR_022659;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2305204,PMID:15489334
PNLIPRP1	P54315	391	446	414	414	Natural variant	ID=VAR_022659;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2305204,PMID:15489334
PNLIPRP1	P54315	68	110	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	76	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	76	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	104	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	104	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	68	110	104	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	104	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	118	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	118	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	126	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	126	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	133	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	110	155	133	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	387	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	387	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	399	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	399	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	412	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	412	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	432	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
PNLIPRP1	P54315	391	446	432	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPL
LMBR1	Q8WVP7	408	462	1	490	Chain	ID=PRO_0000053906;Note=Limb region 1 protein homolog
LMBR1	Q8WVP7	408	462	405	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1	Q8WVP7	408	462	427	447	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1	Q8WVP7	408	462	448	490	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1	Q8WVP7	408	462	205	466	Alternative sequence	ID=VSP_016888;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LMNB1	P20700	462	497	2	583	Chain	ID=PRO_0000063816;Note=Lamin-B1
LMNB1	P20700	497	537	2	583	Chain	ID=PRO_0000063816;Note=Lamin-B1
LMNB1	P20700	537	573	2	583	Chain	ID=PRO_0000063816;Note=Lamin-B1
LMNB1	P20700	462	497	430	546	Domain	Note=LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01187
LMNB1	P20700	497	537	430	546	Domain	Note=LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01187
LMNB1	P20700	537	573	430	546	Domain	Note=LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01187
LMNB1	P20700	462	497	387	586	Region	Note=Tail
LMNB1	P20700	497	537	387	586	Region	Note=Tail
LMNB1	P20700	537	573	387	586	Region	Note=Tail
LMNB1	P20700	537	573	552	559	Compositional bias	Note=Glu-rich (highly acidic%3B could be involved in chromatin binding)
LMNB1	P20700	462	497	483	483	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LMNB1	P20700	497	537	534	534	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LMNB1	P20700	497	537	532	532	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
LMNB1	P20700	537	573	547	547	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
LMNB1	P20700	497	537	501	501	Natural variant	ID=VAR_031646;Note=A->V;Dbxref=dbSNP:rs36105360
LMNB1	P20700	462	497	460	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	462	497	470	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	462	497	478	483	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	462	497	495	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	497	537	495	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	497	537	509	511	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	497	537	512	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	497	537	523	525	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	497	537	527	532	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LMNB1	P20700	537	573	538	546	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UMN
LONRF2	Q1L5Z9	533	585	1	754	Chain	ID=PRO_0000277670;Note=LON peptidase N-terminal domain and RING finger protein 2
LONRF2	Q1L5Z9	533	585	535	735	Domain	Note=Lon N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01123
LONRF2	Q1L5Z9	533	585	562	562	Natural variant	ID=VAR_035953;Note=In a colorectal cancer sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs773205136,PMID:16959974
LONRF3	Q496Y0	312	353	1	759	Chain	ID=PRO_0000277671;Note=LON peptidase N-terminal domain and RING finger protein 3
LONRF3	Q496Y0	312	353	312	344	Repeat	Note=TPR 4
LONRF3	Q496Y0	312	353	313	353	Alternative sequence	ID=VSP_023080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LONP1	P36776	354	382	68	959	Chain	ID=PRO_0000026734;Note=Lon protease homolog%2C mitochondrial
LONP1	P36776	354	382	124	368	Domain	Note=Lon N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01123
MTSS1	O43312	410	468	1	755	Chain	ID=PRO_0000096639;Note=Metastasis suppressor protein 1
MTSS1	O43312	345	410	1	755	Chain	ID=PRO_0000096639;Note=Metastasis suppressor protein 1
MTSS1	O43312	345	410	238	359	Compositional bias	Note=Ser-rich
MTSS1	O43312	410	468	425	425	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R1S4
MTSS1	O43312	410	468	345	426	Alternative sequence	ID=VSP_007421;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTSS1	O43312	345	410	345	426	Alternative sequence	ID=VSP_007421;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTSS1	O43312	345	410	346	409	Alternative sequence	ID=VSP_016216;Note=In isoform 3. LSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSW->NSSSSASSEASETCQSVSECSSPTSVSSGSTMGAWVSTE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477
MTSS1L	Q765P7	351	376	1	747	Chain	ID=PRO_0000319610;Note=MTSS1-like protein
MTSS1L	Q765P7	208	244	1	747	Chain	ID=PRO_0000319610;Note=MTSS1-like protein
MTSS1L	Q765P7	208	244	1	252	Domain	Note=IMD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00668
MTSS1L	Q765P7	351	376	252	383	Compositional bias	Note=Ser-rich
MTSS1L	Q765P7	351	376	295	747	Alternative sequence	ID=VSP_031515;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP11	Q86VZ4	417	449	38	500	Chain	ID=PRO_0000017337;Note=Low-density lipoprotein receptor-related protein 11
LRP11	Q86VZ4	346	417	38	500	Chain	ID=PRO_0000017337;Note=Low-density lipoprotein receptor-related protein 11
LRP11	Q86VZ4	417	449	38	450	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP11	Q86VZ4	346	417	38	450	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP11	Q86VZ4	346	417	401	401	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP11	Q86VZ4	417	449	238	500	Alternative sequence	ID=VSP_017536;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP11	Q86VZ4	346	417	238	500	Alternative sequence	ID=VSP_017536;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP11	Q86VZ4	346	417	351	351	Natural variant	ID=VAR_025538;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854254,PMID:15489334
LRP11	Q86VZ4	417	449	442	442	Natural variant	ID=VAR_056003;Note=G->R;Dbxref=dbSNP:rs9478144
LRP1B	Q9NZR2	4520	4553	21	4599	Chain	ID=PRO_0000017319;Note=Low-density lipoprotein receptor-related protein 1B
LRP1B	Q9NZR2	3798	3843	21	4599	Chain	ID=PRO_0000017319;Note=Low-density lipoprotein receptor-related protein 1B
LRP1B	Q9NZR2	834	881	21	4599	Chain	ID=PRO_0000017319;Note=Low-density lipoprotein receptor-related protein 1B
LRP1B	Q9NZR2	3798	3843	25	4444	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1B	Q9NZR2	834	881	25	4444	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1B	Q9NZR2	4520	4553	4468	4599	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1B	Q9NZR2	834	881	794	834	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1B	Q9NZR2	834	881	844	882	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1B	Q9NZR2	3798	3843	3801	3843	Domain	Note=EGF-like 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1B	Q9NZR2	834	881	845	857	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1B	Q9NZR2	834	881	852	870	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1B	Q9NZR2	834	881	864	881	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1B	Q9NZR2	3798	3843	3805	3818	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1B	Q9NZR2	3798	3843	3812	3827	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1B	Q9NZR2	3798	3843	3829	3842	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	520	599	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	1115	1182	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	2639	2689	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	3408	3448	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	4146	4193	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	4193	4251	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	4364	4397	20	4544	Chain	ID=PRO_0000017317;Note=Prolow-density lipoprotein receptor-related protein 1
LRP1	Q07954	520	599	20	3943	Chain	ID=PRO_0000302750;Note=Low-density lipoprotein receptor-related protein 1 515 kDa subunit
LRP1	Q07954	1115	1182	20	3943	Chain	ID=PRO_0000302750;Note=Low-density lipoprotein receptor-related protein 1 515 kDa subunit
LRP1	Q07954	2639	2689	20	3943	Chain	ID=PRO_0000302750;Note=Low-density lipoprotein receptor-related protein 1 515 kDa subunit
LRP1	Q07954	3408	3448	20	3943	Chain	ID=PRO_0000302750;Note=Low-density lipoprotein receptor-related protein 1 515 kDa subunit
LRP1	Q07954	4146	4193	3944	4544	Chain	ID=PRO_0000302751;Note=Low-density lipoprotein receptor-related protein 1 85 kDa subunit
LRP1	Q07954	4193	4251	3944	4544	Chain	ID=PRO_0000302751;Note=Low-density lipoprotein receptor-related protein 1 85 kDa subunit
LRP1	Q07954	4364	4397	3944	4544	Chain	ID=PRO_0000302751;Note=Low-density lipoprotein receptor-related protein 1 85 kDa subunit
LRP1	Q07954	520	599	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	1115	1182	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	2639	2689	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	3408	3448	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	4146	4193	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	4193	4251	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	4364	4397	20	4419	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	520	599	474	520	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1	Q07954	520	599	571	613	Repeat	Note=LDL-receptor class B 4
LRP1	Q07954	1115	1182	1102	1142	Domain	Note=LDL-receptor class A 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1	Q07954	1115	1182	1143	1182	Domain	Note=LDL-receptor class A 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1	Q07954	2639	2689	2603	2641	Domain	Note=LDL-receptor class A 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1	Q07954	2639	2689	2642	2690	Domain	Note=LDL-receptor class A 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1	Q07954	3408	3448	3372	3410	Domain	Note=LDL-receptor class A 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1	Q07954	3408	3448	3411	3450	Domain	Note=LDL-receptor class A 23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP1	Q07954	4146	4193	4147	4183	Domain	Note=EGF-like 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1	Q07954	4193	4251	4196	4232	Domain	Note=EGF-like 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1	Q07954	4193	4251	4232	4268	Domain	Note=EGF-like 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1	Q07954	4364	4397	4340	4375	Domain	Note=EGF-like 21;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1	Q07954	4364	4397	4373	4409	Domain	Note=EGF-like 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP1	Q07954	1115	1182	1154	1154	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	1115	1182	1155	1155	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	4146	4193	4179	4179	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	4364	4397	4364	4364	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP1	Q07954	1115	1182	1104	1118	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	1115	1182	1112	1131	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	1115	1182	1125	1140	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	1115	1182	1145	1159	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	1115	1182	1152	1172	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	1115	1182	1166	1182	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	2639	2689	2624	2639	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	2639	2689	2644	2666	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	2639	2689	2660	2679	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	2639	2689	2673	2688	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	3408	3448	3393	3408	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	3408	3448	3413	3426	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	3408	3448	3420	3439	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	3408	3448	3433	3448	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4146	4193	4151	4160	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4146	4193	4156	4169	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4146	4193	4171	4182	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4193	4251	4200	4210	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4193	4251	4204	4220	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4193	4251	4222	4231	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4193	4251	4236	4246	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4193	4251	4240	4256	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4364	4397	4365	4374	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4364	4397	4377	4387	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	4364	4397	4381	4397	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP1	Q07954	520	599	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP1	Q07954	1115	1182	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP1	Q07954	2639	2689	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP1	Q07954	3408	3448	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP1	Q07954	4146	4193	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP1	Q07954	4193	4251	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRP1	Q07954	4364	4397	293	4544	Alternative sequence	ID=VSP_056920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LHCGR	P22888	227	288	27	699	Chain	ID=PRO_0000012780;Note=Lutropin-choriogonadotropic hormone receptor
LHCGR	P22888	78	102	27	699	Chain	ID=PRO_0000012780;Note=Lutropin-choriogonadotropic hormone receptor
LHCGR	P22888	227	288	27	363	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LHCGR	P22888	78	102	27	363	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LHCGR	P22888	78	102	96	115	Repeat	Note=LRR 1
LHCGR	P22888	227	288	223	244	Repeat	Note=LRR 6
LHCGR	P22888	78	102	99	99	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LHCGR	P22888	227	288	227	289	Alternative sequence	ID=VSP_001962;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LHCGR	P22888	227	288	284	284	Natural variant	ID=VAR_003550;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10215412;Dbxref=PMID:10215412
LHCGR	P22888	227	288	262	263	Sequence conflict	Note=RE->KQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
LHCGR	P22888	227	288	270	270	Sequence conflict	Note=E->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LHCGR	P22888	227	288	274	274	Sequence conflict	Note=T->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP4	O75096	1092	1121	21	1905	Chain	ID=PRO_0000017325;Note=Low-density lipoprotein receptor-related protein 4
LRP4	O75096	394	436	21	1905	Chain	ID=PRO_0000017325;Note=Low-density lipoprotein receptor-related protein 4
LRP4	O75096	1092	1121	21	1725	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP4	O75096	394	436	21	1725	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP4	O75096	394	436	354	394	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP4	O75096	394	436	395	434	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP4	O75096	1092	1121	1093	1135	Repeat	Note=LDL-receptor class B 11
LRP4	O75096	394	436	399	409	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP4	O75096	394	436	405	418	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP4	O75096	394	436	420	433	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LSM14B	Q9BX40	142	198	2	385	Chain	ID=PRO_0000187093;Note=Protein LSM14 homolog B
LSM14B	Q9BX40	198	224	2	385	Chain	ID=PRO_0000187093;Note=Protein LSM14 homolog B
LSM14B	Q9BX40	142	198	154	154	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
LSM14B	Q9BX40	142	198	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LSM14B	Q9BX40	142	198	45	142	Alternative sequence	ID=VSP_014659;Note=In isoform 3. SFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGL->MAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGCLFCFRSLFTYTQSHIVLFRVPTGPGTLEREEMER;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LSM14B	Q9BX40	142	198	143	220	Alternative sequence	ID=VSP_014660;Note=In isoform 2. GAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQ->EKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSPCS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LSM14B	Q9BX40	198	224	143	220	Alternative sequence	ID=VSP_014660;Note=In isoform 2. GAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQ->EKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSPCS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LSAMP	Q13449	171	216	29	315	Chain	ID=PRO_0000015102;Note=Limbic system-associated membrane protein
LSAMP	Q13449	171	216	132	214	Domain	Note=Ig-like C2-type 2
LSAMP	Q13449	171	216	153	197	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
LRP8	Q14114	892	951	33	963	Chain	ID=PRO_0000017332;Note=Low-density lipoprotein receptor-related protein 8
LRP8	Q14114	736	811	33	963	Chain	ID=PRO_0000017332;Note=Low-density lipoprotein receptor-related protein 8
LRP8	Q14114	476	551	33	963	Chain	ID=PRO_0000017332;Note=Low-density lipoprotein receptor-related protein 8
LRP8	Q14114	375	417	33	963	Chain	ID=PRO_0000017332;Note=Low-density lipoprotein receptor-related protein 8
LRP8	Q14114	335	375	33	963	Chain	ID=PRO_0000017332;Note=Low-density lipoprotein receptor-related protein 8
LRP8	Q14114	165	294	33	963	Chain	ID=PRO_0000017332;Note=Low-density lipoprotein receptor-related protein 8
LRP8	Q14114	736	811	42	826	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	476	551	42	826	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	375	417	42	826	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	335	375	42	826	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	165	294	42	826	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	892	951	848	963	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	165	294	166	202	Domain	Note=LDL-receptor class A 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP8	Q14114	165	294	205	246	Domain	Note=LDL-receptor class A 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP8	Q14114	165	294	258	295	Domain	Note=LDL-receptor class A 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP8	Q14114	375	417	336	375	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP8	Q14114	335	375	336	375	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP8	Q14114	375	417	376	415	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LRP8	Q14114	476	551	462	508	Repeat	Note=LDL-receptor class B 1
LRP8	Q14114	476	551	509	551	Repeat	Note=LDL-receptor class B 2
LRP8	Q14114	736	811	740	798	Region	Note=Clustered O-linked oligosaccharides
LRP8	Q14114	165	294	176	176	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	476	551	518	518	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	476	551	538	538	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	736	811	772	772	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	736	811	807	807	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP8	Q14114	165	294	167	179	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	174	192	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	186	201	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	206	221	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	213	234	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	228	245	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	259	272	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	267	285	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	279	294	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	335	375	340	351	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	335	375	347	360	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	335	375	362	374	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	375	417	380	390	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	375	417	386	399	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	375	417	401	414	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LRP8	Q14114	165	294	166	295	Alternative sequence	ID=VSP_010305;Note=In isoform 2. LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11152697;Dbxref=PMID:11152697
LRP8	Q14114	165	294	166	166	Alternative sequence	ID=VSP_038181;Note=In isoform 4. L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	335	375	167	336	Alternative sequence	ID=VSP_010306;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	165	294	167	336	Alternative sequence	ID=VSP_010306;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	736	811	737	812	Alternative sequence	ID=VSP_010307;Note=In isoform 2. APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHY->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11152697;Dbxref=PMID:11152697
LRP8	Q14114	892	951	893	951	Alternative sequence	ID=VSP_010308;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11152697,ECO:0000303|PubMed:15489334;Dbxref=PMID:11152697,PMID:15489334
LRP8	Q14114	736	811	736	736	Natural variant	ID=VAR_059079;Note=R->Q;Dbxref=dbSNP:rs5172
LRP8	Q14114	165	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	165	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	375	417	405	405	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	476	551	488	488	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP8	Q14114	335	375	339	341	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	335	375	342	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	335	375	348	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	335	375	355	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	335	375	359	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	335	375	368	372	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	375	417	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	375	417	385	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	375	417	396	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	375	417	405	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	375	417	409	412	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	375	417	414	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	473	478	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	479	481	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	485	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	489	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	501	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	506	509	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	510	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	516	519	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	520	525	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	530	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	540	548	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LRP8	Q14114	476	551	549	552	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4X
LSM6	P62312	31	69	1	80	Chain	ID=PRO_0000125575;Note=U6 snRNA-associated Sm-like protein LSm6
LSM6	P62312	31	69	1	80	Chain	ID=PRO_0000125575;Note=U6 snRNA-associated Sm-like protein LSm6
LSM6	P62312	31	69	59	59	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LSM6	P62312	31	69	59	59	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MS4A8	Q9BY19	73	114	1	250	Chain	ID=PRO_0000158645;Note=Membrane-spanning 4-domains subfamily A member 8
MS4A8	Q9BY19	114	134	1	250	Chain	ID=PRO_0000158645;Note=Membrane-spanning 4-domains subfamily A member 8
MS4A8	Q9BY19	134	178	1	250	Chain	ID=PRO_0000158645;Note=Membrane-spanning 4-domains subfamily A member 8
MS4A8	Q9BY19	73	114	1	74	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	73	114	75	95	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	73	114	96	98	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	73	114	99	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	114	134	99	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	114	134	120	136	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	134	178	120	136	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	134	178	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	134	178	158	180	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A8	Q9BY19	73	114	95	95	Natural variant	ID=VAR_053523;Note=V->L;Dbxref=dbSNP:rs35956659
MS4A8	Q9BY19	73	114	83	83	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAPKBP1	O60336	166	212	2	1514	Chain	ID=PRO_0000334158;Note=Mitogen-activated protein kinase-binding protein 1
MAPKBP1	O60336	396	445	2	1514	Chain	ID=PRO_0000334158;Note=Mitogen-activated protein kinase-binding protein 1
MAPKBP1	O60336	166	212	132	173	Repeat	Note=WD 2
MAPKBP1	O60336	166	212	175	213	Repeat	Note=WD 3
MAPKBP1	O60336	396	445	387	436	Repeat	Note=WD 6
MAPKBP1	O60336	166	212	1	499	Alternative sequence	ID=VSP_033629;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAPKBP1	O60336	396	445	1	499	Alternative sequence	ID=VSP_033629;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAPKBP1	O60336	396	445	216	1514	Alternative sequence	ID=VSP_033631;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAPKBP1	O60336	396	445	274	396	Alternative sequence	ID=VSP_033632;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15491607;Dbxref=PMID:15489334,PMID:15491607
MAPKBP1	O60336	166	212	204	204	Natural variant	ID=VAR_043343;Note=Y->S;Dbxref=dbSNP:rs4354909
MTMR12	Q9C0I1	504	558	1	747	Chain	ID=PRO_0000315825;Note=Myotubularin-related protein 12
MTMR12	Q9C0I1	448	504	1	747	Chain	ID=PRO_0000315825;Note=Myotubularin-related protein 12
MTMR12	Q9C0I1	504	558	205	643	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR12	Q9C0I1	448	504	205	643	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR12	Q9C0I1	504	558	449	558	Region	Note=Interaction with MTM1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12847286;Dbxref=PMID:12847286
MTMR12	Q9C0I1	448	504	449	558	Region	Note=Interaction with MTM1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12847286;Dbxref=PMID:12847286
MTMR12	Q9C0I1	504	558	449	558	Alternative sequence	ID=VSP_030721;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTMR12	Q9C0I1	448	504	449	558	Alternative sequence	ID=VSP_030721;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTMR12	Q9C0I1	504	558	505	558	Alternative sequence	ID=VSP_030722;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIN7C	Q9NUP9	52	76	2	197	Chain	ID=PRO_0000189629;Note=Protein lin-7 homolog C
LIN7C	Q9NUP9	52	76	10	65	Domain	Note=L27;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
LIN7C	Q9NUP9	52	76	45	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
LIPC	P11150	91	152	23	499	Chain	ID=PRO_0000017769;Note=Hepatic triacylglycerol lipase
LIPC	P11150	191	269	23	499	Chain	ID=PRO_0000017769;Note=Hepatic triacylglycerol lipase
LIPC	P11150	390	462	23	499	Chain	ID=PRO_0000017769;Note=Hepatic triacylglycerol lipase
LIPC	P11150	91	152	23	499	Chain	ID=PRO_0000017769;Note=Hepatic triacylglycerol lipase
LIPC	P11150	191	269	23	499	Chain	ID=PRO_0000017769;Note=Hepatic triacylglycerol lipase
LIPC	P11150	390	462	23	499	Chain	ID=PRO_0000017769;Note=Hepatic triacylglycerol lipase
LIPC	P11150	390	462	352	486	Domain	Note=PLAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
LIPC	P11150	390	462	352	486	Domain	Note=PLAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
LIPC	P11150	191	269	181	193	Region	Note=Heparin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPC	P11150	191	269	181	193	Region	Note=Heparin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPC	P11150	191	269	194	194	Active site	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10037
LIPC	P11150	191	269	194	194	Active site	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10037
LIPC	P11150	390	462	397	397	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPC	P11150	390	462	397	397	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPC	P11150	91	152	95	95	Natural variant	ID=VAR_004206;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:12966036;Dbxref=dbSNP:rs6078,PMID:10391209,PMID:12966036
LIPC	P11150	91	152	95	95	Natural variant	ID=VAR_004206;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:12966036;Dbxref=dbSNP:rs6078,PMID:10391209,PMID:12966036
LIPC	P11150	91	152	134	134	Natural variant	ID=VAR_004207;Note=In HL deficiency. V->VHYTVAV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10660332;Dbxref=PMID:10660332
LIPC	P11150	91	152	134	134	Natural variant	ID=VAR_004207;Note=In HL deficiency. V->VHYTVAV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10660332;Dbxref=PMID:10660332
LIPC	P11150	191	269	215	215	Natural variant	ID=VAR_004208;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:2324091,ECO:0000269|PubMed:2447084,ECO:0000269|PubMed:2828141;Dbxref=dbSNP:rs6083,PMID:10391209,PMID:12966036,PMID:14702039,PMID:2324091,PMID:2447084,PMID:2828141
LIPC	P11150	191	269	215	215	Natural variant	ID=VAR_004208;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:2324091,ECO:0000269|PubMed:2447084,ECO:0000269|PubMed:2828141;Dbxref=dbSNP:rs6083,PMID:10391209,PMID:12966036,PMID:14702039,PMID:2324091,PMID:2447084,PMID:2828141
LIPC	P11150	390	462	405	405	Natural variant	ID=VAR_004210;Note=In HL deficiency. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:1301939;Dbxref=dbSNP:rs113298164,PMID:12966036,PMID:1301939
LIPC	P11150	390	462	405	405	Natural variant	ID=VAR_004210;Note=In HL deficiency. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:1301939;Dbxref=dbSNP:rs113298164,PMID:12966036,PMID:1301939
LIPC	P11150	390	462	409	409	Natural variant	ID=VAR_017026;Note=D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12966036;Dbxref=dbSNP:rs142036980,PMID:12966036
LIPC	P11150	390	462	409	409	Natural variant	ID=VAR_017026;Note=D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12966036;Dbxref=dbSNP:rs142036980,PMID:12966036
LIPC	P11150	390	462	440	440	Natural variant	ID=VAR_014179;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs6079,PMID:10391209
LIPC	P11150	390	462	440	440	Natural variant	ID=VAR_014179;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs6079,PMID:10391209
LIPC	P11150	191	269	256	256	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LIPC	P11150	191	269	256	256	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	2011	2072	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	1562	1588	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	1010	1039	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	838	883	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	595	667	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	471	513	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	235	280	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	235	280	222	276	Repeat	Note=HEAT 6
MTOR	P42345	235	280	277	313	Repeat	Note=HEAT 7
MTOR	P42345	471	513	446	494	Repeat	Note=HEAT 11
MTOR	P42345	471	513	495	529	Repeat	Note=HEAT 12
MTOR	P42345	595	667	564	596	Repeat	Note=HEAT 14
MTOR	P42345	595	667	597	636	Repeat	Note=HEAT 15
MTOR	P42345	595	667	637	683	Repeat	Note=HEAT 16
MTOR	P42345	838	883	814	853	Repeat	Note=HEAT 20
MTOR	P42345	838	883	857	893	Repeat	Note=HEAT 21
MTOR	P42345	1010	1039	989	1027	Repeat	Note=HEAT 24
MTOR	P42345	1010	1039	1029	1068	Repeat	Note=HEAT 25
MTOR	P42345	1562	1588	1382	1982	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
MTOR	P42345	1562	1588	1542	1574	Repeat	Note=TPR 7
MTOR	P42345	1562	1588	1575	1614	Repeat	Note=TPR 8
MTOR	P42345	595	667	1	651	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
MTOR	P42345	471	513	1	651	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
MTOR	P42345	235	280	1	651	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
MTOR	P42345	2011	2072	2012	2144	Region	Note=Sufficient for interaction with the FKBP1A/rapamycin complex;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTOR	P42345	595	667	624	624	Natural variant	ID=VAR_078824;Note=In FCORD2%3B somatic mutation%3B unknown pathological significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25799227;Dbxref=dbSNP:rs913197212,PMID:25799227
MTOR	P42345	2011	2072	2011	2011	Natural variant	ID=VAR_041542;Note=In an ovarian mucinous carcinoma sample%3B somatic mutation. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MTOR	P42345	471	513	482	484	Sequence conflict	Note=VFT->FFN;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	471	513	489	489	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	471	513	513	513	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	838	883	857	857	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	1562	1588	1557	1577	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	1562	1588	1584	1586	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	1562	1588	1587	1605	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	2011	2072	1985	2020	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	2011	2072	2025	2039	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DRI
MTOR	P42345	2011	2072	2044	2058	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DRI
MTOR	P42345	2011	2072	2065	2091	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DRI
LOXHD1	Q8IVV2	1489	1551	1	2067	Chain	ID=PRO_0000308256;Note=Lipoxygenase homology domain-containing protein 1
LOXHD1	Q8IVV2	1159	1198	1	2067	Chain	ID=PRO_0000308256;Note=Lipoxygenase homology domain-containing protein 1
LOXHD1	Q8IVV2	477	506	1	2067	Chain	ID=PRO_0000308256;Note=Lipoxygenase homology domain-containing protein 1
LOXHD1	Q8IVV2	477	506	425	540	Domain	Note=PLAT 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
LOXHD1	Q8IVV2	1159	1198	1100	1225	Domain	Note=PLAT 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
LOXHD1	Q8IVV2	1489	1551	1421	1539	Domain	Note=PLAT 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152
LOXHD1	Q8IVV2	1489	1551	1	1555	Alternative sequence	ID=VSP_028947;Note=In isoform 5 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LOXHD1	Q8IVV2	1159	1198	1	1555	Alternative sequence	ID=VSP_028947;Note=In isoform 5 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LOXHD1	Q8IVV2	477	506	1	1555	Alternative sequence	ID=VSP_028947;Note=In isoform 5 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LOXHD1	Q8IVV2	477	506	1	905	Alternative sequence	ID=VSP_059671;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LOXHD1	Q8IVV2	1159	1198	1177	1177	Natural variant	ID=VAR_056928;Note=T->M;Dbxref=dbSNP:rs7244681
ASPG	Q86U10	143	171	1	573	Chain	ID=PRO_0000324163;Note=60 kDa lysophospholipase
ASPG	Q86U10	312	350	1	573	Chain	ID=PRO_0000324163;Note=60 kDa lysophospholipase
ASPG	Q86U10	391	423	1	573	Chain	ID=PRO_0000324163;Note=60 kDa lysophospholipase
ASPG	Q86U10	143	171	9	355	Domain	Note=Asparaginase/glutaminase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01068
ASPG	Q86U10	312	350	9	355	Domain	Note=Asparaginase/glutaminase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01068
ASPG	Q86U10	143	171	141	170	Repeat	Note=ANK 1
ASPG	Q86U10	391	423	399	429	Repeat	Note=ANK 2
ASPG	Q86U10	143	171	41	350	Region	Note=Asparaginase
ASPG	Q86U10	312	350	41	350	Region	Note=Asparaginase
ASPG	Q86U10	312	350	344	344	Natural variant	ID=VAR_059133;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs8012505,PMID:15489334
LNX1	Q8TBB1	450	495	1	728	Chain	ID=PRO_0000055913;Note=E3 ubiquitin-protein ligase LNX
LNX1	Q8TBB1	450	495	381	464	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
LNP1	A1A4G5	52	129	1	178	Chain	ID=PRO_0000341357;Note=Leukemia NUP98 fusion partner 1
TRMU	O75648	118	159	1	421	Chain	ID=PRO_0000121708;Note=Mitochondrial tRNA-specific 2-thiouridylase 1
TRMU	O75648	118	159	126	126	Binding site	Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRMU	O75648	118	159	127	127	Site	Note=Interaction with tRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRMU	O75648	118	159	101	222	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TRMU	O75648	118	159	1	154	Alternative sequence	ID=VSP_035391;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRMU	O75648	118	159	155	179	Alternative sequence	ID=VSP_035392;Note=In isoform 3 and isoform 4. FEVRNAVKLLQAADSFKDQTFFLSQ->MKKSLSRSTLRSPKGFSEIGLKLEM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRMU	O75648	118	159	148	148	Natural variant	ID=VAR_046381;Note=E->K;Dbxref=dbSNP:rs34012206
TRMU	O75648	118	159	139	139	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
LDLRAD2	Q5SZI1	214	268	26	272	Chain	ID=PRO_0000299377;Note=Low-density lipoprotein receptor class A domain-containing protein 2
LDLRAD2	Q5SZI1	214	268	26	272	Chain	ID=PRO_0000299377;Note=Low-density lipoprotein receptor class A domain-containing protein 2
LDLRAD2	Q5SZI1	214	268	26	233	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD2	Q5SZI1	214	268	26	233	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD2	Q5SZI1	214	268	234	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD2	Q5SZI1	214	268	234	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD2	Q5SZI1	214	268	251	272	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD2	Q5SZI1	214	268	251	272	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD2	Q5SZI1	214	268	172	214	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD2	Q5SZI1	214	268	172	214	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRCH3	Q96II8	530	548	23	777	Chain	ID=PRO_0000253484;Note=Leucine-rich repeat and calponin homology domain-containing protein 3
LRCH3	Q96II8	548	572	23	777	Chain	ID=PRO_0000253484;Note=Leucine-rich repeat and calponin homology domain-containing protein 3
LRCH3	Q96II8	588	624	23	777	Chain	ID=PRO_0000253484;Note=Leucine-rich repeat and calponin homology domain-containing protein 3
LRCH3	Q96II8	710	736	23	777	Chain	ID=PRO_0000253484;Note=Leucine-rich repeat and calponin homology domain-containing protein 3
LRCH3	Q96II8	710	736	652	765	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
LRCH3	Q96II8	588	624	611	611	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LRCH3	Q96II8	548	572	549	572	Alternative sequence	ID=VSP_057213;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRCH3	Q96II8	710	736	711	777	Alternative sequence	ID=VSP_021043;Note=In isoform 3. PKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV->VS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRRC7	Q96NW7	477	560	1	1537	Chain	ID=PRO_0000188298;Note=Leucine-rich repeat-containing protein 7
LRRC7	Q96NW7	1285	1332	1	1537	Chain	ID=PRO_0000188298;Note=Leucine-rich repeat-containing protein 7
LRRC7	Q96NW7	477	560	180	1537	Alternative sequence	ID=VSP_010796;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12525888;Dbxref=PMID:12525888
LRRC7	Q96NW7	1285	1332	180	1537	Alternative sequence	ID=VSP_010796;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12525888;Dbxref=PMID:12525888
LRRC7	Q96NW7	1285	1332	1286	1332	Alternative sequence	ID=VSP_010797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10718198;Dbxref=PMID:10718198
LRRK1	Q38SD2	1599	1638	1	2015	Chain	ID=PRO_0000233377;Note=Leucine-rich repeat serine/threonine-protein kinase 1
LRRK1	Q38SD2	1923	1956	1	2015	Chain	ID=PRO_0000233377;Note=Leucine-rich repeat serine/threonine-protein kinase 1
LRRK1	Q38SD2	1599	1638	265	2015	Alternative sequence	ID=VSP_040120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRRK1	Q38SD2	1923	1956	265	2015	Alternative sequence	ID=VSP_040120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRRK1	Q38SD2	1923	1956	1927	1927	Natural variant	ID=VAR_040677;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
LRRK1	Q38SD2	1923	1956	1938	1938	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRRK1	Q38SD2	1923	1956	1938	1938	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRP5	O75197	163	228	32	1615	Chain	ID=PRO_0000017328;Note=Low-density lipoprotein receptor-related protein 5
LRP5	O75197	294	338	32	1615	Chain	ID=PRO_0000017328;Note=Low-density lipoprotein receptor-related protein 5
LRP5	O75197	1212	1254	32	1615	Chain	ID=PRO_0000017328;Note=Low-density lipoprotein receptor-related protein 5
LRP5	O75197	1254	1333	32	1615	Chain	ID=PRO_0000017328;Note=Low-density lipoprotein receptor-related protein 5
LRP5	O75197	1333	1370	32	1615	Chain	ID=PRO_0000017328;Note=Low-density lipoprotein receptor-related protein 5
LRP5	O75197	1370	1449	32	1615	Chain	ID=PRO_0000017328;Note=Low-density lipoprotein receptor-related protein 5
LRP5	O75197	163	228	32	1384	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	294	338	32	1384	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	1212	1254	32	1384	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	1254	1333	32	1384	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	1333	1370	32	1384	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	1370	1449	32	1384	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	1370	1449	1385	1407	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	1370	1449	1408	1615	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP5	O75197	163	228	163	206	Repeat	Note=LDL-receptor class B 3
LRP5	O75197	163	228	166	169	Repeat	Note=YWTD 3
LRP5	O75197	163	228	207	247	Repeat	Note=LDL-receptor class B 4
LRP5	O75197	294	338	295	337	Domain	Note=EGF-like 1
LRP5	O75197	1212	1254	1213	1254	Domain	Note=EGF-like 4
LRP5	O75197	1254	1333	1213	1254	Domain	Note=EGF-like 4
LRP5	O75197	1254	1333	1258	1296	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1297	1333	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1333	1370	1297	1333	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1333	1370	1335	1371	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1370	1449	1335	1371	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	163	228	32	288	Region	Note=Beta-propeller 1
LRP5	O75197	1212	1254	945	1212	Region	Note=Beta-propeller 4
LRP5	O75197	294	338	299	310	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	294	338	306	321	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	294	338	323	336	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1212	1254	1217	1228	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1212	1254	1224	1238	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1212	1254	1240	1253	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1259	1273	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1266	1286	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1280	1295	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1298	1310	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1305	1323	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1254	1333	1317	1332	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1333	1370	1336	1348	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1333	1370	1343	1361	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1333	1370	1355	1370	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	1370	1449	1355	1370	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LRP5	O75197	163	228	171	171	Natural variant	ID=VAR_021808;Note=In OPTA1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12579474;Dbxref=dbSNP:rs121908669,PMID:12579474
LRP5	O75197	163	228	171	171	Natural variant	ID=VAR_021809;Note=In HBM%3B also in HBM individuals with enlarged mandible and torus palatinus%3B abolishes interaction with MESD%3B impairs transport to cell surface%3B no enhancement of DKK1 binding by MESD resulting in impaired inhibition of Wnt signaling by DKK1. G->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11741193,ECO:0000269|PubMed:12015390,ECO:0000269|PubMed:15143163,ECO:0000269|PubMed:19746449;Dbxref=dbSNP:rs121908668,PMID:11741193,PMID:12015390,PMID:15143163,PMID:19746449
LRP5	O75197	163	228	173	173	Natural variant	ID=VAR_018465;Note=In EVR4%3B an individual with abnormal retinal vasculature and retinal folds. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15024691,ECO:0000269|PubMed:16252235;Dbxref=dbSNP:rs80358306,PMID:15024691,PMID:16252235
LRP5	O75197	163	228	203	203	Natural variant	ID=VAR_063945;Note=In OPPG. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16252235;Dbxref=dbSNP:rs760548029,PMID:16252235
LRP5	O75197	163	228	214	214	Natural variant	ID=VAR_021810;Note=In WENHY. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12579474;Dbxref=dbSNP:rs121908671,PMID:12579474
LRP5	O75197	163	228	214	214	Natural variant	ID=VAR_021811;Note=In WENHY. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12579474;Dbxref=dbSNP:rs121908672,PMID:12579474
LRP5	O75197	294	338	307	307	Natural variant	ID=VAR_063947;Note=In OPPG. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16252235;Dbxref=dbSNP:rs1219101402,PMID:16252235
LRP5	O75197	1212	1254	1253	1253	Natural variant	ID=VAR_063978;Note=In EVR4. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20340138;Dbxref=dbSNP:rs768615287,PMID:20340138
LRP5	O75197	1254	1333	1330	1330	Natural variant	ID=VAR_021817;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12509515,ECO:0000269|PubMed:12579474,ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:15077203;Dbxref=dbSNP:rs3736228,PMID:12509515,PMID:12579474,PMID:14727154,PMID:15077203
LRP5	O75197	1333	1370	1361	1361	Natural variant	ID=VAR_018467;Note=In EVR4%3B autosomal dominant%3B has mildly reduced Wnt or Norrin signal transduction. C->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15024691,ECO:0000269|PubMed:16252235;Dbxref=dbSNP:rs80358320,PMID:15024691,PMID:16252235
LRP5	O75197	1333	1370	1367	1367	Natural variant	ID=VAR_021224;Note=In EVR4%3B autosomal recessive. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15346351,ECO:0000269|PubMed:16252235;Dbxref=dbSNP:rs28939709,PMID:15346351,PMID:16252235
LRP5	O75197	1370	1449	1401	1401	Natural variant	ID=VAR_063979;Note=In OPPG. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16252235;Dbxref=PMID:16252235
LTBP2	Q14767	1484	1527	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	1344	1392	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	1258	1302	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	1217	1258	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	1175	1217	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	1092	1134	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	969	1009	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	929	969	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	809	843	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	717	789	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	662	717	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	621	662	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	596	621	36	1821	Chain	ID=PRO_0000007643;Note=Latent-transforming growth factor beta-binding protein 2
LTBP2	Q14767	596	621	552	604	Domain	Note=TB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	662	717	622	662	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	621	662	622	662	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	717	789	672	724	Domain	Note=TB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	662	717	672	724	Domain	Note=TB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	929	969	887	929	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	969	1009	930	969	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	929	969	930	969	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	969	1009	970	1009	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1092	1134	1051	1092	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1092	1134	1093	1134	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1175	1217	1135	1175	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1217	1258	1176	1217	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1175	1217	1176	1217	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1258	1302	1218	1258	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1217	1258	1218	1258	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1258	1302	1259	1302	Domain	Note=EGF-like 14%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1344	1392	1303	1344	Domain	Note=EGF-like 15%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1344	1392	1345	1387	Domain	Note=EGF-like 16%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1484	1527	1485	1527	Domain	Note=EGF-like 17%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1344	1392	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	1258	1302	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	1217	1258	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	1175	1217	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	1092	1134	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	969	1009	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	929	969	856	1372	Compositional bias	Note=Cys-rich
LTBP2	Q14767	596	621	616	616	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP2	Q14767	809	843	811	811	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP2	Q14767	621	662	626	637	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	621	662	632	646	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	621	662	648	661	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	662	717	674	696	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	662	717	683	709	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	662	717	697	712	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	717	789	698	724	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	662	717	698	724	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP2	Q14767	929	969	934	945	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	929	969	940	954	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	929	969	956	968	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	969	1009	974	985	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	969	1009	980	994	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	969	1009	997	1008	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1092	1134	1097	1108	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1092	1134	1103	1117	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1092	1134	1120	1133	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1175	1217	1180	1192	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1175	1217	1186	1201	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1175	1217	1203	1216	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1217	1258	1222	1233	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1217	1258	1228	1242	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1217	1258	1244	1257	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1258	1302	1263	1276	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1258	1302	1271	1285	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1258	1302	1289	1301	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1344	1392	1349	1361	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1344	1392	1356	1370	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1344	1392	1372	1386	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1484	1527	1489	1502	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1484	1527	1497	1511	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1484	1527	1513	1526	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP2	Q14767	1175	1217	1177	1177	Natural variant	ID=VAR_068647;Note=In WMS3. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22539340;Dbxref=dbSNP:rs137854856,PMID:22539340
LTBP4	Q8N2S1	331	356	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	397	452	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	502	542	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	586	628	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	670	751	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	751	793	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	793	833	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	877	919	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	919	960	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1004	1048	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1138	1227	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1227	1251	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1251	1294	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1294	1343	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1343	1394	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	1394	1521	28	1624	Chain	ID=PRO_0000310964;Note=Latent-transforming growth factor beta-binding protein 4
LTBP4	Q8N2S1	331	356	287	339	Domain	Note=TB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	397	452	357	397	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	397	452	407	459	Domain	Note=TB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	586	628	545	586	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	586	628	587	628	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	629	670	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	671	708	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	710	751	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	751	793	710	751	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	751	793	752	793	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	793	833	752	793	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	877	919	834	877	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	877	919	878	919	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	919	960	878	919	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	919	960	920	960	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1138	1227	1181	1235	Domain	Note=TB 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1227	1251	1181	1235	Domain	Note=TB 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1251	1294	1253	1295	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1294	1343	1253	1295	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1294	1343	1296	1337	Domain	Note=EGF-like 14%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1343	1394	1349	1402	Domain	Note=TB 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1394	1521	1349	1402	Domain	Note=TB 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	502	542	478	565	Compositional bias	Note=Pro-rich
LTBP4	Q8N2S1	586	628	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	670	751	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	751	793	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	793	833	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	877	919	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	919	960	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	1004	1048	549	1118	Compositional bias	Note=Cys-rich
LTBP4	Q8N2S1	1138	1227	1119	1175	Compositional bias	Note=Pro-rich
LTBP4	Q8N2S1	1394	1521	1407	1492	Compositional bias	Note=Pro-rich
LTBP4	Q8N2S1	331	356	352	352	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP4	Q8N2S1	397	452	425	425	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP4	Q8N2S1	1138	1227	1200	1200	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP4	Q8N2S1	1294	1343	1339	1339	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP4	Q8N2S1	397	452	409	431	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	397	452	418	444	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	397	452	432	447	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	397	452	433	459	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	586	628	591	603	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	586	628	598	612	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	586	628	614	627	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	675	687	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	682	696	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	698	707	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	714	726	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	721	735	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	670	751	737	750	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	751	793	756	768	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	751	793	763	777	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	751	793	779	792	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	877	919	882	894	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	877	919	888	903	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	877	919	905	918	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	919	960	924	935	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	919	960	930	944	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	919	960	946	959	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1138	1227	1183	1206	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1138	1227	1193	1218	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1138	1227	1193	1193	Disulfide bond	Note=Interchain (with C-33 in TGFB1)%3B in linked form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14766
LTBP4	Q8N2S1	1138	1227	1207	1223	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1138	1227	1208	1235	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1227	1251	1208	1235	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1138	1227	1218	1218	Disulfide bond	Note=Interchain (with C-33 in TGFB1)%3B in linked form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14766
LTBP4	Q8N2S1	1251	1294	1257	1270	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1251	1294	1265	1279	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1251	1294	1281	1294	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1294	1343	1281	1294	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1294	1343	1300	1312	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1294	1343	1307	1321	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1294	1343	1323	1336	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP4	Q8N2S1	1343	1394	1351	1375	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1343	1394	1361	1387	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1343	1394	1376	1390	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1343	1394	1377	1402	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	1394	1521	1377	1402	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP4	Q8N2S1	331	356	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	397	452	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	502	542	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	586	628	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	670	751	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	751	793	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	793	833	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	877	919	1	902	Alternative sequence	ID=VSP_029362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	877	919	903	919	Alternative sequence	ID=VSP_029366;Note=In isoform 4. CTCAPGYRPGPRGASCL->MLGGAGGGPGLRTPCPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	919	960	903	919	Alternative sequence	ID=VSP_029366;Note=In isoform 4. CTCAPGYRPGPRGASCL->MLGGAGGGPGLRTPCPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	1004	1048	1007	1092	Alternative sequence	ID=VSP_029367;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LTBP4	Q8N2S1	670	751	679	679	Natural variant	ID=VAR_037121;Note=P->A;Dbxref=dbSNP:rs34299942
LTBP4	Q8N2S1	751	793	787	787	Natural variant	ID=VAR_037122;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23440719,ECO:0000269|PubMed:9660815;Dbxref=dbSNP:rs1131620,PMID:23440719,PMID:9660815
LTBP4	Q8N2S1	793	833	820	820	Natural variant	ID=VAR_037123;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23440719,ECO:0000269|PubMed:9660815;Dbxref=dbSNP:rs1051303,PMID:23440719,PMID:9660815
LTBP4	Q8N2S1	1138	1227	1141	1141	Natural variant	ID=VAR_037124;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23440719,ECO:0000269|PubMed:9271198,ECO:0000269|PubMed:9660815;Dbxref=dbSNP:rs10880,PMID:23440719,PMID:9271198,PMID:9660815
LTBP4	Q8N2S1	331	356	346	346	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	502	542	526	526	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	502	542	526	526	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	670	751	686	686	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1139	1139	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1142	1142	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1151	1151	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1165	1165	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1169	1170	Sequence conflict	Note=ST->RK;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1173	1173	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1138	1227	1180	1180	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1394	1521	1402	1402	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP4	Q8N2S1	1394	1521	1512	1512	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMTOR2	Q9Y2Q5	77	107	1	125	Chain	ID=PRO_0000220960;Note=Ragulator complex protein LAMTOR2
LAMTOR2	Q9Y2Q5	77	107	78	107	Alternative sequence	ID=VSP_040980;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LAMTOR2	Q9Y2Q5	77	107	79	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9X
LAMTOR2	Q9Y2Q5	77	107	89	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9X
LAMTOR2	Q9Y2Q5	77	107	101	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9X
LY96	Q9Y6Y9	67	110	19	160	Chain	ID=PRO_0000018619;Note=Lymphocyte antigen 96
LY96	Q9Y6Y9	67	110	37	148	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2E56,ECO:0000244|PDB:2E59,ECO:0000244|PDB:2Z65,ECO:0000269|PubMed:17569869,ECO:0000269|PubMed:17803912;Dbxref=PMID:17569869,PMID:17803912
LY96	Q9Y6Y9	67	110	95	105	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2E56,ECO:0000244|PDB:2E59,ECO:0000244|PDB:2Z65,ECO:0000269|PubMed:17569869,ECO:0000269|PubMed:17803912;Dbxref=PMID:17569869,PMID:17803912
LY96	Q9Y6Y9	67	110	38	68	Alternative sequence	ID=VSP_055045;Note=In isoform 2. DKMQYPISINVNPCIELKRSKGLLHIFYIPR->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LY96	Q9Y6Y9	67	110	95	95	Mutagenesis	Note=Abolishes LPS-response. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11435474;Dbxref=PMID:11435474
LY96	Q9Y6Y9	67	110	75	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E56
LY96	Q9Y6Y9	67	110	90	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E56
LY96	Q9Y6Y9	67	110	97	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E56
LY96	Q9Y6Y9	67	110	103	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E56
LOX	P28300	345	377	169	417	Chain	ID=PRO_0000018521;Note=Protein-lysine 6-oxidase
LOX	P28300	345	377	213	417	Region	Note=Lysyl-oxidase like
LOX	P28300	345	377	355	355	Modified residue	Note=2'%2C4'%2C5'-topaquinone;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P33072
LOX	P28300	345	377	351	361	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P33072
LOX	P28300	345	377	320	355	Cross-link	Note=Lysine tyrosylquinone (Lys-Tyr);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P33072
LOX	P28300	345	377	348	348	Natural variant	ID=VAR_077540;Note=In AAT10%3B 21%25 decrease of lysyl oxidase activity. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26838787;Dbxref=PMID:26838787
LYG1	Q8N1E2	14	49	1	19	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
LYG1	Q8N1E2	14	49	1	19	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
LYG1	Q8N1E2	14	49	20	194	Chain	ID=PRO_0000012023;Note=Lysozyme g-like protein 1
LYG1	Q8N1E2	14	49	20	194	Chain	ID=PRO_0000012023;Note=Lysozyme g-like protein 1
LYG1	Q8N1E2	14	49	24	80	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LYG1	Q8N1E2	14	49	24	80	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LYG1	Q8N1E2	14	49	38	49	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LYG1	Q8N1E2	14	49	38	49	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GAA	P10253	318	358	70	952	Chain	ID=PRO_0000018566;Note=Lysosomal alpha-glucosidase
GAA	P10253	479	517	70	952	Chain	ID=PRO_0000018566;Note=Lysosomal alpha-glucosidase
GAA	P10253	318	358	70	952	Chain	ID=PRO_0000018566;Note=Lysosomal alpha-glucosidase
GAA	P10253	479	517	70	952	Chain	ID=PRO_0000018566;Note=Lysosomal alpha-glucosidase
GAA	P10253	318	358	123	952	Chain	ID=PRO_0000018567;Note=76 kDa lysosomal alpha-glucosidase
GAA	P10253	479	517	123	952	Chain	ID=PRO_0000018567;Note=76 kDa lysosomal alpha-glucosidase
GAA	P10253	318	358	123	952	Chain	ID=PRO_0000018567;Note=76 kDa lysosomal alpha-glucosidase
GAA	P10253	479	517	123	952	Chain	ID=PRO_0000018567;Note=76 kDa lysosomal alpha-glucosidase
GAA	P10253	318	358	204	952	Chain	ID=PRO_0000018568;Note=70 kDa lysosomal alpha-glucosidase
GAA	P10253	479	517	204	952	Chain	ID=PRO_0000018568;Note=70 kDa lysosomal alpha-glucosidase
GAA	P10253	318	358	204	952	Chain	ID=PRO_0000018568;Note=70 kDa lysosomal alpha-glucosidase
GAA	P10253	479	517	204	952	Chain	ID=PRO_0000018568;Note=70 kDa lysosomal alpha-glucosidase
GAA	P10253	318	358	318	318	Natural variant	ID=VAR_068588;Note=In GSD2. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	318	358	318	318	Natural variant	ID=VAR_068588;Note=In GSD2. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	318	358	318	318	Natural variant	ID=VAR_004289;Note=In GSD2%3B severe. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1652892;Dbxref=dbSNP:rs121907936,PMID:1652892
GAA	P10253	318	358	318	318	Natural variant	ID=VAR_004289;Note=In GSD2%3B severe. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1652892;Dbxref=dbSNP:rs121907936,PMID:1652892
GAA	P10253	318	358	324	324	Natural variant	ID=VAR_029029;Note=In GSD2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11071489;Dbxref=dbSNP:rs750030887,PMID:11071489
GAA	P10253	318	358	324	324	Natural variant	ID=VAR_029029;Note=In GSD2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11071489;Dbxref=dbSNP:rs750030887,PMID:11071489
GAA	P10253	318	358	330	330	Natural variant	ID=VAR_029030;Note=In GSD2%3B infantile form%3B severe. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16782080;Dbxref=PMID:16782080
GAA	P10253	318	358	330	330	Natural variant	ID=VAR_029030;Note=In GSD2%3B infantile form%3B severe. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16782080;Dbxref=PMID:16782080
GAA	P10253	318	358	335	335	Natural variant	ID=VAR_068589;Note=In GSD2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22644586;Dbxref=dbSNP:rs730880022,PMID:22644586
GAA	P10253	318	358	335	335	Natural variant	ID=VAR_068589;Note=In GSD2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22644586;Dbxref=dbSNP:rs730880022,PMID:22644586
GAA	P10253	318	358	335	335	Natural variant	ID=VAR_068590;Note=In GSD2. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=dbSNP:rs202095215,PMID:18425781
GAA	P10253	318	358	335	335	Natural variant	ID=VAR_068590;Note=In GSD2. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=dbSNP:rs202095215,PMID:18425781
GAA	P10253	318	358	347	347	Natural variant	ID=VAR_068591;Note=In GSD2. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	318	358	347	347	Natural variant	ID=VAR_068591;Note=In GSD2. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	318	358	355	355	Natural variant	ID=VAR_018086;Note=In GSD2%3B infantile form%3B severe%3B loss of activity. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14695532,ECO:0000269|PubMed:14972326,ECO:0000269|PubMed:16917947,ECO:0000269|PubMed:17643989,ECO:0000269|PubMed:18429042;Dbxref=dbSNP:rs766074609,PMID:14695532,PMID:14972326,PMID:16917947,PMID:17643989,PMID:18429042
GAA	P10253	318	358	355	355	Natural variant	ID=VAR_018086;Note=In GSD2%3B infantile form%3B severe%3B loss of activity. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14695532,ECO:0000269|PubMed:14972326,ECO:0000269|PubMed:16917947,ECO:0000269|PubMed:17643989,ECO:0000269|PubMed:18429042;Dbxref=dbSNP:rs766074609,PMID:14695532,PMID:14972326,PMID:16917947,PMID:17643989,PMID:18429042
GAA	P10253	479	517	481	481	Natural variant	ID=VAR_004292;Note=In GSD2%3B severe%3B loss of activity. W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10189220,ECO:0000269|PubMed:14695532;Dbxref=dbSNP:rs772883420,PMID:10189220,PMID:14695532
GAA	P10253	479	517	481	481	Natural variant	ID=VAR_004292;Note=In GSD2%3B severe%3B loss of activity. W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10189220,ECO:0000269|PubMed:14695532;Dbxref=dbSNP:rs772883420,PMID:10189220,PMID:14695532
GAA	P10253	479	517	482	482	Natural variant	ID=VAR_068598;Note=In GSD2. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	479	517	482	482	Natural variant	ID=VAR_068598;Note=In GSD2. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	479	517	483	483	Natural variant	ID=VAR_068599;Note=In GSD2. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	479	517	483	483	Natural variant	ID=VAR_068599;Note=In GSD2. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18425781;Dbxref=PMID:18425781
GAA	P10253	479	517	486	486	Natural variant	ID=VAR_068600;Note=In GSD2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19588081;Dbxref=PMID:19588081
GAA	P10253	479	517	486	486	Natural variant	ID=VAR_068600;Note=In GSD2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19588081;Dbxref=PMID:19588081
GAA	P10253	479	517	489	489	Natural variant	ID=VAR_029037;Note=In GSD2%3B severe. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16917947,ECO:0000269|PubMed:18429042;Dbxref=dbSNP:rs398123169,PMID:16917947,PMID:18429042
GAA	P10253	479	517	489	489	Natural variant	ID=VAR_029037;Note=In GSD2%3B severe. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16917947,ECO:0000269|PubMed:18429042;Dbxref=dbSNP:rs398123169,PMID:16917947,PMID:18429042
GAA	P10253	479	517	516	516	Mutagenesis	Note=Loss of activity. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1856189;Dbxref=PMID:1856189
GAA	P10253	479	517	516	516	Mutagenesis	Note=Loss of activity. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1856189;Dbxref=PMID:1856189
GAA	P10253	318	358	318	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	318	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	324	326	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	324	326	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	327	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	327	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	337	342	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	337	342	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	347	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	318	358	347	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	477	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	477	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	483	486	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	483	486	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	493	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	493	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	514	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
GAA	P10253	479	517	514	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NN4
LYRM1	O43325	0	53	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	53	84	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	0	53	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	53	84	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	0	53	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	53	84	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	0	53	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	53	84	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	0	53	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	53	84	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	0	53	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYRM1	O43325	53	84	1	122	Chain	ID=PRO_0000174310;Note=LYR motif-containing protein 1
LYPD5	Q6UWN5	64	123	26	225	Chain	ID=PRO_0000226763;Note=Ly6/PLAUR domain-containing protein 5
LYPD5	Q6UWN5	64	123	120	120	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LYPD5	Q6UWN5	64	123	90	90	Natural variant	ID=VAR_059885;Note=A->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12975309,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs11547806,PMID:12975309,PMID:14702039
LYPD6B	Q8NI32	52	85	40	164	Chain	ID=PRO_0000321950;Note=Ly6/PLAUR domain-containing protein 6B
LYPD6B	Q8NI32	52	85	40	164	Chain	ID=PRO_0000321950;Note=Ly6/PLAUR domain-containing protein 6B
LYPD6B	Q8NI32	52	85	60	151	Domain	Note=UPAR/Ly6
LYPD6B	Q8NI32	52	85	60	151	Domain	Note=UPAR/Ly6
LYPD6B	Q8NI32	52	85	62	90	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57,ECO:0000250|UniProtKB:P0DP58
LYPD6B	Q8NI32	52	85	62	90	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57,ECO:0000250|UniProtKB:P0DP58
LYPD6B	Q8NI32	52	85	65	74	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57,ECO:0000250|UniProtKB:P0DP58
LYPD6B	Q8NI32	52	85	65	74	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57,ECO:0000250|UniProtKB:P0DP58
LYPD6B	Q8NI32	52	85	83	109	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57,ECO:0000250|UniProtKB:P0DP58
LYPD6B	Q8NI32	52	85	83	109	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57,ECO:0000250|UniProtKB:P0DP58
LPAR2	Q9HBW0	0	247	1	351	Chain	ID=PRO_0000069424;Note=Lysophosphatidic acid receptor 2
LPAR2	Q9HBW0	0	247	1	33	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	34	54	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	55	69	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	70	90	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	91	103	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	104	126	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	127	146	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	147	167	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	168	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	189	209	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	210	242	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	243	263	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	10	10	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	18	18	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPAR2	Q9HBW0	0	247	221	221	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LOXL1	Q08397	404	449	95	574	Chain	ID=PRO_0000018529;Note=Lysyl oxidase homolog 1
LOXL1	Q08397	404	449	370	574	Region	Note=Lysyl-oxidase like
LOXL1	Q08397	404	449	449	449	Metal binding	Note=Copper;Ontology_term=ECO:0000255;evidence=ECO:0000255
LOXL1	Q08397	404	449	448	497	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P33072
LRPPRC	P42704	1275	1300	60	1394	Chain	ID=PRO_0000084467;Note=Leucine-rich PPR motif-containing protein%2C mitochondrial
LRPPRC	P42704	655	693	60	1394	Chain	ID=PRO_0000084467;Note=Leucine-rich PPR motif-containing protein%2C mitochondrial
LRPPRC	P42704	640	655	60	1394	Chain	ID=PRO_0000084467;Note=Leucine-rich PPR motif-containing protein%2C mitochondrial
LRPPRC	P42704	655	693	678	709	Repeat	Note=PPR 9
LRPPRC	P42704	1275	1300	1121	1394	Region	Note=RNA-binding
LRPPRC	P42704	640	655	648	648	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRPPRC	P42704	655	693	676	676	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRRC43	Q8N309	497	540	1	656	Chain	ID=PRO_0000311908;Note=Leucine-rich repeat-containing protein 43
LRRC43	Q8N309	497	540	515	553	Compositional bias	Note=Lys-rich
LRRC69	Q6ZNQ3	193	217	1	347	Chain	ID=PRO_0000336072;Note=Leucine-rich repeat-containing protein 69
LRRC69	Q6ZNQ3	217	251	1	347	Chain	ID=PRO_0000336072;Note=Leucine-rich repeat-containing protein 69
LRRC69	Q6ZNQ3	193	217	177	199	Repeat	Note=LRR 7
LRRC69	Q6ZNQ3	193	217	200	222	Repeat	Note=LRR 8
LRRC69	Q6ZNQ3	217	251	200	222	Repeat	Note=LRR 8
LRRC69	Q6ZNQ3	193	217	62	217	Alternative sequence	ID=VSP_033810;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC69	Q6ZNQ3	217	251	62	217	Alternative sequence	ID=VSP_033810;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC71	Q8N4P6	332	382	1	559	Chain	ID=PRO_0000284542;Note=Leucine-rich repeat-containing protein 71
LRRC36	Q1X8D7	251	398	1	754	Chain	ID=PRO_0000275855;Note=Leucine-rich repeat-containing protein 36
LRCH4	O75427	592	618	1	683	Chain	ID=PRO_0000084480;Note=Leucine-rich repeat and calponin homology domain-containing protein 4
LRCH4	O75427	546	592	1	683	Chain	ID=PRO_0000084480;Note=Leucine-rich repeat and calponin homology domain-containing protein 4
LRCH4	O75427	489	517	1	683	Chain	ID=PRO_0000084480;Note=Leucine-rich repeat and calponin homology domain-containing protein 4
LRCH4	O75427	432	454	1	683	Chain	ID=PRO_0000084480;Note=Leucine-rich repeat and calponin homology domain-containing protein 4
LRCH4	O75427	393	431	1	683	Chain	ID=PRO_0000084480;Note=Leucine-rich repeat and calponin homology domain-containing protein 4
LRCH4	O75427	592	618	534	647	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
LRCH4	O75427	546	592	534	647	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
LRCH4	O75427	432	454	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LRCH4	O75427	489	517	511	511	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
LRCH4	O75427	489	517	513	513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LRCH4	O75427	489	517	517	517	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
LRCH4	O75427	546	592	589	589	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LRRC2	Q9BYS8	258	309	1	371	Chain	ID=PRO_0000084491;Note=Leucine-rich repeat-containing protein 2
LRRC2	Q9BYS8	258	309	1	371	Chain	ID=PRO_0000084491;Note=Leucine-rich repeat-containing protein 2
LRRC2	Q9BYS8	258	309	238	260	Repeat	Note=LRR 6
LRRC2	Q9BYS8	258	309	238	260	Repeat	Note=LRR 6
LRRC2	Q9BYS8	258	309	261	283	Repeat	Note=LRR 7
LRRC2	Q9BYS8	258	309	261	283	Repeat	Note=LRR 7
LRRC2	Q9BYS8	258	309	284	305	Repeat	Note=LRR 8
LRRC2	Q9BYS8	258	309	284	305	Repeat	Note=LRR 8
LRRC2	Q9BYS8	258	309	308	329	Repeat	Note=LRR 9
LRRC2	Q9BYS8	258	309	308	329	Repeat	Note=LRR 9
LRSAM1	Q6UWE0	43	58	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	58	84	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	84	107	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	348	362	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	474	501	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	501	533	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	533	566	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	43	58	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	58	84	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	84	107	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	348	362	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	474	501	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	501	533	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	533	566	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	43	58	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	58	84	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	84	107	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	348	362	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	474	501	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	501	533	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	533	566	1	723	Chain	ID=PRO_0000055923;Note=E3 ubiquitin-protein ligase LRSAM1
LRSAM1	Q6UWE0	43	58	30	51	Repeat	Note=LRR 1
LRSAM1	Q6UWE0	43	58	30	51	Repeat	Note=LRR 1
LRSAM1	Q6UWE0	43	58	30	51	Repeat	Note=LRR 1
LRSAM1	Q6UWE0	43	58	56	77	Repeat	Note=LRR 2
LRSAM1	Q6UWE0	58	84	56	77	Repeat	Note=LRR 2
LRSAM1	Q6UWE0	43	58	56	77	Repeat	Note=LRR 2
LRSAM1	Q6UWE0	58	84	56	77	Repeat	Note=LRR 2
LRSAM1	Q6UWE0	43	58	56	77	Repeat	Note=LRR 2
LRSAM1	Q6UWE0	58	84	56	77	Repeat	Note=LRR 2
LRSAM1	Q6UWE0	58	84	82	103	Repeat	Note=LRR 3
LRSAM1	Q6UWE0	84	107	82	103	Repeat	Note=LRR 3
LRSAM1	Q6UWE0	58	84	82	103	Repeat	Note=LRR 3
LRSAM1	Q6UWE0	84	107	82	103	Repeat	Note=LRR 3
LRSAM1	Q6UWE0	58	84	82	103	Repeat	Note=LRR 3
LRSAM1	Q6UWE0	84	107	82	103	Repeat	Note=LRR 3
LRSAM1	Q6UWE0	84	107	105	127	Repeat	Note=LRR 4
LRSAM1	Q6UWE0	84	107	105	127	Repeat	Note=LRR 4
LRSAM1	Q6UWE0	84	107	105	127	Repeat	Note=LRR 4
LRSAM1	Q6UWE0	348	362	254	380	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	348	362	254	380	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	348	362	254	380	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	501	533	510	562	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	533	566	510	562	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	501	533	510	562	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	533	566	510	562	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	501	533	510	562	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	533	566	510	562	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRSAM1	Q6UWE0	43	58	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	58	84	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	84	107	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	348	362	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	43	58	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	58	84	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	84	107	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	348	362	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	43	58	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	58	84	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	84	107	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	348	362	1	420	Alternative sequence	ID=VSP_012660;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	474	501	474	500	Alternative sequence	ID=VSP_012661;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	474	501	474	500	Alternative sequence	ID=VSP_012661;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRSAM1	Q6UWE0	474	501	474	500	Alternative sequence	ID=VSP_012661;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRWD1	Q9UFC0	144	191	1	647	Chain	ID=PRO_0000310994;Note=Leucine-rich repeat and WD repeat-containing protein 1
LRWD1	Q9UFC0	191	226	1	647	Chain	ID=PRO_0000310994;Note=Leucine-rich repeat and WD repeat-containing protein 1
LRWD1	Q9UFC0	226	268	1	647	Chain	ID=PRO_0000310994;Note=Leucine-rich repeat and WD repeat-containing protein 1
LRWD1	Q9UFC0	434	480	1	647	Chain	ID=PRO_0000310994;Note=Leucine-rich repeat and WD repeat-containing protein 1
LRWD1	Q9UFC0	511	563	1	647	Chain	ID=PRO_0000310994;Note=Leucine-rich repeat and WD repeat-containing protein 1
LRWD1	Q9UFC0	434	480	426	472	Repeat	Note=WD 4
LRWD1	Q9UFC0	511	563	484	526	Repeat	Note=WD 5
LRWD1	Q9UFC0	511	563	542	582	Repeat	Note=WD 6
LRWD1	Q9UFC0	191	226	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
LRWD1	Q9UFC0	226	268	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
LRWD1	Q9UFC0	226	268	251	251	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
LRWD1	Q9UFC0	226	268	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18220336,PMID:18669648,PMID:19690332,PMID:23186163,PMID:24275569
LRWD1	Q9UFC0	226	268	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
LRRK2	Q5S007	145	190	1	2527	Chain	ID=PRO_0000086238;Note=Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2	Q5S007	190	235	1	2527	Chain	ID=PRO_0000086238;Note=Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2	Q5S007	235	279	1	2527	Chain	ID=PRO_0000086238;Note=Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2	Q5S007	2127	2192	1	2527	Chain	ID=PRO_0000086238;Note=Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2	Q5S007	2463	2487	1	2527	Chain	ID=PRO_0000086238;Note=Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2	Q5S007	2127	2192	1879	2138	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LRRK2	Q5S007	2127	2192	2139	2183	Repeat	Note=WD 1
LRRK2	Q5S007	2127	2192	2188	2228	Repeat	Note=WD 2
LRRK2	Q5S007	2463	2487	2443	2497	Repeat	Note=WD 7
LRRK2	Q5S007	190	235	228	228	Natural variant	ID=VAR_054740;Note=C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18213618;Dbxref=dbSNP:rs56108242,PMID:18213618
LRRK2	Q5S007	2127	2192	2141	2141	Natural variant	ID=VAR_054747;Note=In PARK8. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18213618;Dbxref=dbSNP:rs111691891,PMID:18213618
LRRK2	Q5S007	2127	2192	2143	2143	Natural variant	ID=VAR_054748;Note=In PARK8. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18213618;Dbxref=dbSNP:rs201271001,PMID:18213618
LRRK2	Q5S007	2463	2487	2466	2466	Natural variant	ID=VAR_054750;Note=In PARK8. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18213618;Dbxref=dbSNP:rs281865057,PMID:18213618
LRRK2	Q5S007	190	235	212	212	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	344	400	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	625	666	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	666	722	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	872	914	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	956	997	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	997	1037	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1037	1078	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1078	1119	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1119	1160	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1160	1201	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1243	1285	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1285	1333	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1333	1394	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	1570	1611	24	1721	Chain	ID=PRO_0000007635;Note=Latent-transforming growth factor beta-binding protein 1
LTBP1	Q14766	344	400	399	431	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	625	666	626	663	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	666	722	677	729	Domain	Note=TB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	872	914	873	910	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	956	997	915	956	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	956	997	957	997	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	997	1037	957	997	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	997	1037	998	1037	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1037	1078	998	1037	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1037	1078	1038	1078	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1078	1119	1038	1078	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1078	1119	1079	1119	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1119	1160	1079	1119	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1119	1160	1120	1160	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1160	1201	1120	1160	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1160	1201	1161	1201	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1243	1285	1202	1243	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1243	1285	1244	1281	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1285	1333	1286	1328	Domain	Note=EGF-like 14%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1333	1394	1347	1401	Domain	Note=TB 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	1570	1611	1524	1577	Domain	Note=TB 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	1333	1394	1344	1411	Region	Note=8-Cys3 region;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8617200,ECO:0000269|PubMed:8939931;Dbxref=PMID:8617200,PMID:8939931
LTBP1	Q14766	1570	1611	1507	1721	Region	Note=C-terminal domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17293099;Dbxref=PMID:17293099
LTBP1	Q14766	1160	1201	1174	1176	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP1	Q14766	956	997	974	974	Modified residue	Note=(3R)-3-hydroxyasparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2350783;Dbxref=PMID:2350783
LTBP1	Q14766	1119	1160	1137	1137	Modified residue	Note=(3R)-3-hydroxyasparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2350783;Dbxref=PMID:2350783
LTBP1	Q14766	1570	1611	1597	1597	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18088087;Dbxref=PMID:18088087
LTBP1	Q14766	344	400	347	347	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP1	Q14766	344	400	378	378	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP1	Q14766	1160	1201	1197	1197	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP1	Q14766	1243	1285	1250	1250	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP1	Q14766	1333	1394	1366	1366	Glycosylation	ID=CAR_000184;Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10677208,ECO:0000269|PubMed:8617200;Dbxref=PMID:10677208,PMID:8617200
LTBP1	Q14766	625	666	630	641	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	625	666	636	650	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	625	666	652	665	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	666	722	679	702	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	666	722	689	714	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	666	722	703	717	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	666	722	704	729	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	872	914	877	889	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	872	914	884	898	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	872	914	900	913	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	956	997	961	972	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	956	997	967	981	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	956	997	984	996	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	997	1037	1002	1013	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	997	1037	1008	1022	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	997	1037	1025	1036	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1037	1078	1042	1053	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1037	1078	1048	1062	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1037	1078	1064	1077	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1078	1119	1083	1094	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1078	1119	1089	1103	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1078	1119	1105	1118	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1119	1160	1124	1135	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1119	1160	1130	1144	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1119	1160	1146	1159	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1160	1201	1165	1177	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1160	1201	1172	1186	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1160	1201	1188	1200	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1243	1285	1248	1260	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1243	1285	1254	1269	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP1	Q14766	1333	1394	1349	1372	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00697,ECO:0000269|PubMed:14607119;Dbxref=PMID:14607119
LTBP1	Q14766	1333	1394	1359	1384	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00697,ECO:0000269|PubMed:14607119;Dbxref=PMID:14607119
LTBP1	Q14766	1333	1394	1359	1359	Disulfide bond	Note=Interchain (with C-33 in TGFB1)%3B in linked form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14607119;Dbxref=PMID:14607119
LTBP1	Q14766	1333	1394	1373	1389	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00697,ECO:0000269|PubMed:14607119;Dbxref=PMID:14607119
LTBP1	Q14766	1333	1394	1374	1401	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00697,ECO:0000269|PubMed:14607119;Dbxref=PMID:14607119
LTBP1	Q14766	1333	1394	1384	1384	Disulfide bond	Note=Interchain (with C-33 in TGFB1)%3B in linked form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14607119;Dbxref=PMID:14607119
LTBP1	Q14766	1570	1611	1552	1577	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP1	Q14766	344	400	327	345	Alternative sequence	ID=VSP_036964;Note=In isoform Short%2C isoform 3 and isoform 5. EGSFPLRYVQDQVAAPFQL->MDTKLMCLLFFFSLPPLLV;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2350783,ECO:0000303|Ref.2,ECO:0000303|Ref.3,ECO:0000303|Ref.8;Dbxref=PMID:15489334,PMID:2350783
LTBP1	Q14766	1333	1394	1348	1348	Mutagenesis	Note=Abolishes interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1%3B when associated with 1382-A--A-1385. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15567420;Dbxref=PMID:15567420
LTBP1	Q14766	1333	1394	1366	1366	Mutagenesis	Note=Abolishes N-glycosylation at this site without affecting ability to interact with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1. N->A%2CQ;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8617200,ECO:0000269|PubMed:8939931;Dbxref=PMID:8617200,PMID:8939931
LTBP1	Q14766	1333	1394	1382	1385	Mutagenesis	Note=Abolishes interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1%3B when associated with A-1348. DNCE->ANCA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15567420;Dbxref=PMID:15567420
LTBP1	Q14766	1333	1394	1385	1388	Mutagenesis	Note=Loss of binding to TGFB1. EIFP->DL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10930463;Dbxref=PMID:10930463
LTBP1	Q14766	666	722	691	691	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	666	722	694	694	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	666	722	710	710	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	666	722	710	710	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	1333	1394	1378	1378	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	1333	1394	1378	1378	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	1333	1394	1378	1378	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	1333	1394	1378	1378	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	1333	1394	1378	1378	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTBP1	Q14766	1333	1394	1340	1342	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1346	1353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1355	1358	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1366	1368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1369	1374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1378	1382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1385	1388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP1	Q14766	1333	1394	1392	1394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KSQ
LTBP3	Q9NS15	1209	1253	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	1081	1128	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	1035	1081	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	825	865	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	784	825	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	743	784	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	702	743	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	659	702	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	354	395	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	323	354	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	110	220	44	1303	Chain	ID=PRO_0000007646;Note=Latent-transforming growth factor beta-binding protein 3
LTBP3	Q9NS15	110	220	109	141	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	323	354	277	331	Domain	Note=TB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
LTBP3	Q9NS15	354	395	355	395	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	659	702	616	659	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	702	743	660	702	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	659	702	660	702	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	784	825	744	784	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	743	784	744	784	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	825	865	785	825	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	784	825	785	825	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	825	865	826	865	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1035	1081	993	1035	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1035	1081	1036	1076	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1081	1128	1082	1122	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	110	220	3	167	Compositional bias	Note=Gly-rich
LTBP3	Q9NS15	825	865	578	894	Compositional bias	Note=Cys-rich
LTBP3	Q9NS15	784	825	578	894	Compositional bias	Note=Cys-rich
LTBP3	Q9NS15	743	784	578	894	Compositional bias	Note=Cys-rich
LTBP3	Q9NS15	702	743	578	894	Compositional bias	Note=Cys-rich
LTBP3	Q9NS15	659	702	578	894	Compositional bias	Note=Cys-rich
LTBP3	Q9NS15	323	354	349	349	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP3	Q9NS15	825	865	845	845	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBP3	Q9NS15	110	220	113	123	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	110	220	117	129	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	110	220	131	140	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	354	395	359	370	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	354	395	365	379	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	354	395	381	394	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	659	702	664	676	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	659	702	670	685	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	659	702	687	701	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	743	784	748	759	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	743	784	754	768	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	743	784	770	783	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	784	825	789	800	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	784	825	795	809	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	784	825	811	824	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	825	865	830	841	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	825	865	836	850	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	825	865	852	864	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1035	1081	1040	1051	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1035	1081	1046	1060	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1035	1081	1062	1075	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1081	1128	1086	1097	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1081	1128	1092	1106	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1081	1128	1108	1121	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
LTBP3	Q9NS15	1081	1128	1082	1128	Alternative sequence	ID=VSP_009241;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LTBP3	Q9NS15	659	702	696	696	Natural variant	ID=VAR_080565;Note=In GPHYSD3%3B unknown pathological significance%3B no effect on TGF-beta secretion. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27068007;Dbxref=PMID:27068007
LTK	P29376	673	706	17	864	Chain	ID=PRO_0000016738;Note=Leukocyte tyrosine kinase receptor
LTK	P29376	416	448	17	864	Chain	ID=PRO_0000016738;Note=Leukocyte tyrosine kinase receptor
LTK	P29376	271	332	17	864	Chain	ID=PRO_0000016738;Note=Leukocyte tyrosine kinase receptor
LTK	P29376	170	219	17	864	Chain	ID=PRO_0000016738;Note=Leukocyte tyrosine kinase receptor
LTK	P29376	416	448	17	424	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTK	P29376	271	332	17	424	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTK	P29376	170	219	17	424	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTK	P29376	416	448	425	449	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTK	P29376	673	706	450	864	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTK	P29376	673	706	510	786	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LTK	P29376	673	706	676	676	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
LTK	P29376	170	219	170	170	Alternative sequence	ID=VSP_002946;Note=In isoform Lambda P1. G->VAAASGDGAAPAPGARAAWGPGERAFLGAGSPAQRGEAPGPRRFPPPLPAG;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	673	706	171	864	Alternative sequence	ID=VSP_002947;Note=In isoform Lambda P1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	416	448	171	864	Alternative sequence	ID=VSP_002947;Note=In isoform Lambda P1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	271	332	171	864	Alternative sequence	ID=VSP_002947;Note=In isoform Lambda P1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	170	219	171	864	Alternative sequence	ID=VSP_002947;Note=In isoform Lambda P1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	271	332	274	334	Alternative sequence	ID=VSP_035109;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1655406;Dbxref=PMID:14702039,PMID:1655406
LTK	P29376	416	448	448	448	Alternative sequence	ID=VSP_002948;Note=In isoform Lambda P3. L->GTKRLAGTVDSRLLLSSELGWVSAAGSRRQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	673	706	449	864	Alternative sequence	ID=VSP_002949;Note=In isoform Lambda P3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LTK	P29376	673	706	673	673	Natural variant	ID=VAR_046109;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55876255,PMID:17344846
CAMK4	Q16566	80	101	1	473	Chain	ID=PRO_0000086106;Note=Calcium/calmodulin-dependent protein kinase type IV
CAMK4	Q16566	80	101	1	473	Chain	ID=PRO_0000086106;Note=Calcium/calmodulin-dependent protein kinase type IV
CAMK4	Q16566	80	101	46	300	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CAMK4	Q16566	80	101	46	300	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CAMK4	Q16566	80	101	91	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4O
CAMK4	Q16566	80	101	91	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4O
KCNH6	Q9H252	744	780	1	994	Chain	ID=PRO_0000054013;Note=Potassium voltage-gated channel subfamily H member 6
KCNH6	Q9H252	744	780	512	994	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH6	Q9H252	744	780	503	994	Alternative sequence	ID=VSP_000980;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KCNH6	Q9H252	744	780	745	780	Alternative sequence	ID=VSP_000978;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KCNQ4	P56696	377	430	1	695	Chain	ID=PRO_0000054037;Note=Potassium voltage-gated channel subfamily KQT member 4
KCNQ4	P56696	538	581	1	695	Chain	ID=PRO_0000054037;Note=Potassium voltage-gated channel subfamily KQT member 4
KCNQ4	P56696	377	430	318	695	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNQ4	P56696	538	581	318	695	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNQ4	P56696	538	581	546	650	Region	Note=A-domain (Tetramerization)
KCNQ4	P56696	377	430	377	430	Alternative sequence	ID=VSP_001013;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10025409;Dbxref=PMID:10025409
KCNQ4	P56696	538	581	526	548	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOW
KIDINS220	Q9ULH0	1239	1272	1	1771	Chain	ID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
KIDINS220	Q9ULH0	1176	1195	1	1771	Chain	ID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
KIDINS220	Q9ULH0	480	540	1	1771	Chain	ID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
KIDINS220	Q9ULH0	480	540	1	499	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIDINS220	Q9ULH0	480	540	500	520	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIDINS220	Q9ULH0	480	540	521	524	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIDINS220	Q9ULH0	480	540	525	545	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIDINS220	Q9ULH0	1239	1272	707	1771	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIDINS220	Q9ULH0	1176	1195	707	1771	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIDINS220	Q9ULH0	480	540	440	953	Domain	Note=KAP NTPase
KIDINS220	Q9ULH0	1176	1195	1	1228	Alternative sequence	ID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIDINS220	Q9ULH0	480	540	1	1228	Alternative sequence	ID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIDINS220	Q9ULH0	1239	1272	1031	1771	Alternative sequence	ID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KIDINS220	Q9ULH0	1176	1195	1031	1771	Alternative sequence	ID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KIDINS220	Q9ULH0	1176	1195	1138	1194	Alternative sequence	ID=VSP_031866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIDINS220	Q9ULH0	1176	1195	1177	1195	Alternative sequence	ID=VSP_031867;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KIDINS220	Q9ULH0	480	540	538	538	Natural variant	ID=VAR_048285;Note=I->T;Dbxref=dbSNP:rs2289229
KDM5D	Q9BY66	703	767	1	1539	Chain	ID=PRO_0000200588;Note=Lysine-specific demethylase 5D
KDM5D	Q9BY66	265	309	1	1539	Chain	ID=PRO_0000200588;Note=Lysine-specific demethylase 5D
KDM5D	Q9BY66	208	264	1	1539	Chain	ID=PRO_0000200588;Note=Lysine-specific demethylase 5D
KDM5D	Q9BY66	167	207	1	1539	Chain	ID=PRO_0000200588;Note=Lysine-specific demethylase 5D
KDM5D	Q9BY66	167	207	79	169	Domain	Note=ARID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00355
KDM5D	Q9BY66	703	767	697	749	Zinc finger	Note=C5HC2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29375
KDM5D	Q9BY66	265	309	291	291	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41229
KDM5D	Q9BY66	265	309	307	307	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41229
KDM5D	Q9BY66	167	207	205	205	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41229
KDM5D	Q9BY66	208	264	229	229	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41229
KDM5D	Q9BY66	208	264	244	244	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41229
KDM5D	Q9BY66	265	309	272	272	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41229
KDM5D	Q9BY66	167	207	118	174	Alternative sequence	ID=VSP_000317;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9039502;Dbxref=PMID:15489334,PMID:9039502
KDM5D	Q9BY66	167	207	161	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQE
KDM8	Q8N371	266	281	1	416	Chain	ID=PRO_0000292010;Note=JmjC domain-containing protein 5
KDM8	Q8N371	281	331	1	416	Chain	ID=PRO_0000292010;Note=JmjC domain-containing protein 5
KDM8	Q8N371	331	362	1	416	Chain	ID=PRO_0000292010;Note=JmjC domain-containing protein 5
KDM8	Q8N371	266	281	271	416	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM8	Q8N371	281	331	271	416	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM8	Q8N371	331	362	271	416	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM8	Q8N371	281	331	321	321	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4GJY,ECO:0000244|PDB:4GJZ,ECO:0000255|PROSITE-ProRule:PRU00538,ECO:0000305|PubMed:22851697,ECO:0000305|PubMed:24100311;Dbxref=PMID:22851697,PMID:24100311
KDM8	Q8N371	281	331	323	323	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4GJY,ECO:0000244|PDB:4GJZ,ECO:0000255|PROSITE-ProRule:PRU00538,ECO:0000305|PubMed:22851697,ECO:0000305|PubMed:24100311;Dbxref=PMID:22851697,PMID:24100311
KDM8	Q8N371	266	281	272	272	Binding site	Note=2-oxoglutarate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000305;evidence=ECO:0000244|PDB:3UYJ,ECO:0000244|PDB:4GJZ,ECO:0000244|PDB:4QU1,ECO:0000244|PDB:5FBJ,ECO:0000269|PubMed:22851697,ECO:0000305|PubMed:24100311;Dbxref=PMID:22851697,PMID:24100311
KDM8	Q8N371	281	331	318	318	Binding site	Note=2-oxoglutarate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000305;evidence=ECO:0000244|PDB:3UYJ,ECO:0000244|PDB:4GJZ,ECO:0000244|PDB:4QU1,ECO:0000244|PDB:5FBJ,ECO:0000269|PubMed:22851697,ECO:0000305|PubMed:24100311;Dbxref=PMID:22851697,PMID:24100311
KDM8	Q8N371	281	331	327	327	Binding site	Note=2-oxoglutarate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000305;evidence=ECO:0000244|PDB:3UYJ,ECO:0000244|PDB:4GJZ,ECO:0000244|PDB:4QU1,ECO:0000244|PDB:5FBJ,ECO:0000269|PubMed:22851697,ECO:0000305|PubMed:24100311;Dbxref=PMID:22851697,PMID:24100311
KDM8	Q8N371	331	362	336	336	Binding site	Note=2-oxoglutarate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000305;evidence=ECO:0000244|PDB:3UYJ,ECO:0000244|PDB:4GJZ,ECO:0000244|PDB:4QU1,ECO:0000244|PDB:5FBJ,ECO:0000269|PubMed:22851697,ECO:0000305|PubMed:24100311;Dbxref=PMID:22851697,PMID:24100311
KDM8	Q8N371	266	281	167	362	Alternative sequence	ID=VSP_026370;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
KDM8	Q8N371	281	331	167	362	Alternative sequence	ID=VSP_026370;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
KDM8	Q8N371	331	362	167	362	Alternative sequence	ID=VSP_026370;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
KDM8	Q8N371	281	331	302	302	Natural variant	ID=VAR_032928;Note=E->D;Dbxref=dbSNP:rs34445573
KDM8	Q8N371	281	331	321	323	Mutagenesis	Note=Fails to cleave HIST1H3A. HQD->AQA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28982940;Dbxref=PMID:28982940
KDM8	Q8N371	281	331	321	321	Mutagenesis	Note=Loss of H3K36me2 demethylase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20457893;Dbxref=PMID:20457893
KDM8	Q8N371	331	362	335	336	Mutagenesis	Note=Loss of interaction with HIST1H3A. Fails to cleave HIST1H3A. RK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28982940;Dbxref=PMID:28982940
KDM8	Q8N371	266	281	271	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	266	281	278	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	278	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	283	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	293	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	298	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	306	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	317	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	281	331	324	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	331	362	324	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	331	362	336	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	331	362	343	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	331	362	355	359	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
KDM8	Q8N371	331	362	360	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GJZ
MNT	Q99583	218	231	2	582	Chain	ID=PRO_0000127281;Note=Max-binding protein MNT
MNT	Q99583	218	231	220	271	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
KDSR	Q06136	259	293	26	332	Chain	ID=PRO_0000031982;Note=3-ketodihydrosphingosine reductase
KDSR	Q06136	231	259	26	332	Chain	ID=PRO_0000031982;Note=3-ketodihydrosphingosine reductase
KDSR	Q06136	203	231	26	332	Chain	ID=PRO_0000031982;Note=3-ketodihydrosphingosine reductase
KDSR	Q06136	139	203	26	332	Chain	ID=PRO_0000031982;Note=3-ketodihydrosphingosine reductase
KDSR	Q06136	85	107	26	332	Chain	ID=PRO_0000031982;Note=3-ketodihydrosphingosine reductase
KDSR	Q06136	66	85	26	332	Chain	ID=PRO_0000031982;Note=3-ketodihydrosphingosine reductase
KDSR	Q06136	259	293	26	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	231	259	26	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	203	231	26	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	139	203	26	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	85	107	26	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	66	85	26	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	259	293	271	291	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	259	293	292	293	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDSR	Q06136	139	203	186	186	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
KDSR	Q06136	139	203	190	190	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305
KDSR	Q06136	139	203	173	173	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
KDSR	Q06136	139	203	139	202	Alternative sequence	ID=VSP_056641;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KDSR	Q06136	85	107	86	107	Natural variant	ID=VAR_079186;Note=In EKVP4%3B loss of 3-dehydrosphinganine reductase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575652;Dbxref=PMID:28575652
KDSR	Q06136	139	203	186	186	Natural variant	ID=VAR_079187;Note=In EKVP4. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575652;Dbxref=dbSNP:rs1114167452,PMID:28575652
KDSR	Q06136	259	293	260	293	Natural variant	ID=VAR_079188;Note=In EKVP4%3B loss of 3-dehydrosphinganine reductase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575652;Dbxref=PMID:28575652
GUK1	Q16774	37	51	2	197	Chain	ID=PRO_0000170651;Note=Guanylate kinase
GUK1	Q16774	37	51	2	197	Chain	ID=PRO_0000170651;Note=Guanylate kinase
GUK1	Q16774	37	51	2	197	Chain	ID=PRO_0000170651;Note=Guanylate kinase
GUK1	Q16774	37	51	2	197	Chain	ID=PRO_0000170651;Note=Guanylate kinase
GUK1	Q16774	37	51	2	197	Chain	ID=PRO_0000170651;Note=Guanylate kinase
GUK1	Q16774	37	51	4	186	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
GUK1	Q16774	37	51	4	186	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
GUK1	Q16774	37	51	4	186	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
GUK1	Q16774	37	51	4	186	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
GUK1	Q16774	37	51	4	186	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
GUK1	Q16774	37	51	44	44	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
GUK1	Q16774	37	51	44	44	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
GUK1	Q16774	37	51	44	44	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
GUK1	Q16774	37	51	44	44	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
GUK1	Q16774	37	51	44	44	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
KHK	P50053	31	69	1	298	Chain	ID=PRO_0000080088;Note=Ketohexokinase
KHK	P50053	70	114	1	298	Chain	ID=PRO_0000080088;Note=Ketohexokinase
KHK	P50053	31	69	41	41	Binding site	Note=D-fructose%3B via amide nitrogen
KHK	P50053	31	69	42	42	Binding site	Note=D-fructose
KHK	P50053	31	69	45	45	Binding site	Note=D-fructose
KHK	P50053	70	114	108	108	Binding site	Note=ATP
KHK	P50053	70	114	72	115	Alternative sequence	ID=VSP_004669;Note=In isoform A. LVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDT->VLDDLRRYSVDLRYTVFQTTGSVPIATVIINEASGSRTILYYDR;Ontology_term=ECO:0000305;evidence=ECO:0000305
KHK	P50053	31	69	40	40	Natural variant	ID=VAR_006072;Note=In FRUCT%3B loss of ketohexokinase function%3B insoluble. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12941785,ECO:0000269|PubMed:7833921;Dbxref=dbSNP:rs104893643,PMID:12941785,PMID:7833921
KHK	P50053	31	69	43	43	Natural variant	ID=VAR_006073;Note=In FRUCT%3B no effect on ketohexokinase function%3B decreases enzyme activity but no effect in substrate affinity%3B decreases thermal stability. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12941785,ECO:0000269|PubMed:7833921;Dbxref=dbSNP:rs104893644,PMID:12941785,PMID:7833921
KHK	P50053	31	69	49	49	Natural variant	ID=VAR_006074;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7833921;Dbxref=dbSNP:rs2304681,PMID:7833921
KHK	P50053	31	69	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	31	69	33	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	31	69	42	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	31	69	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	31	69	67	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	70	114	67	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	70	114	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	70	114	90	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQQ
KHK	P50053	70	114	96	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	70	114	103	105	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
KHK	P50053	70	114	108	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLZ
MKI67	P46013	133	493	1	3256	Chain	ID=PRO_0000084301;Note=Proliferation marker protein Ki-67
MKI67	P46013	133	493	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PVX6
MKI67	P46013	133	493	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MKI67	P46013	133	493	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PVX6
MKI67	P46013	133	493	308	308	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163
MKI67	P46013	133	493	328	328	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
MKI67	P46013	133	493	347	347	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MKI67	P46013	133	493	352	352	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
MKI67	P46013	133	493	357	357	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163
MKI67	P46013	133	493	374	374	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PVX6
MKI67	P46013	133	493	401	401	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MKI67	P46013	133	493	411	411	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MKI67	P46013	133	493	245	245	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MKI67	P46013	133	493	136	495	Alternative sequence	ID=VSP_004298;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8227122;Dbxref=PMID:8227122
MKI67	P46013	133	493	238	238	Natural variant	ID=VAR_029056;Note=W->R;Dbxref=dbSNP:rs7095325
KIF22	Q14807	630	650	1	665	Chain	ID=PRO_0000125433;Note=Kinesin-like protein KIF22
KIF22	Q14807	630	650	631	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDU
KIF22	Q14807	630	650	642	658	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDU
KIF5B	P33176	789	813	2	963	Chain	ID=PRO_0000125351;Note=Kinesin-1 heavy chain
KIF5B	P33176	527	575	2	963	Chain	ID=PRO_0000125351;Note=Kinesin-1 heavy chain
KIF5B	P33176	96	131	2	963	Chain	ID=PRO_0000125351;Note=Kinesin-1 heavy chain
KIF5B	P33176	96	131	8	325	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF5B	P33176	789	813	329	914	Coiled coil	.
KIF5B	P33176	527	575	329	914	Coiled coil	.
KIF5B	P33176	96	131	102	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2
KIF5B	P33176	96	131	107	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2
KIF5B	P33176	96	131	124	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2
KLHDC8B	Q8IXV7	255	289	1	354	Chain	ID=PRO_0000119131;Note=Kelch domain-containing protein 8B
KLHDC8B	Q8IXV7	255	289	224	281	Repeat	Note=Kelch 6
KLHDC8B	Q8IXV7	255	289	282	329	Repeat	Note=Kelch 7
KLHL29	Q96CT2	580	641	1	875	Chain	ID=PRO_0000119086;Note=Kelch-like protein 29
KLHL29	Q96CT2	580	641	585	635	Repeat	Note=Kelch 1
KLHL29	Q96CT2	580	641	637	683	Repeat	Note=Kelch 2
KCTD1	Q719H9	103	205	1	257	Chain	ID=PRO_0000247144;Note=BTB/POZ domain-containing protein KCTD1
KCTD1	Q719H9	103	205	1	257	Chain	ID=PRO_0000247144;Note=BTB/POZ domain-containing protein KCTD1
KCTD1	Q719H9	103	205	1	257	Chain	ID=PRO_0000247144;Note=BTB/POZ domain-containing protein KCTD1
KCTD1	Q719H9	103	205	107	107	Natural variant	ID=VAR_049722;Note=L->W;Dbxref=dbSNP:rs491684
KCTD1	Q719H9	103	205	107	107	Natural variant	ID=VAR_049722;Note=L->W;Dbxref=dbSNP:rs491684
KCTD1	Q719H9	103	205	107	107	Natural variant	ID=VAR_049722;Note=L->W;Dbxref=dbSNP:rs491684
KCTD1	Q719H9	103	205	141	141	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCTD1	Q719H9	103	205	141	141	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCTD1	Q719H9	103	205	141	141	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCTD1	Q719H9	103	205	105	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXD
KCTD1	Q719H9	103	205	105	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXD
KCTD1	Q719H9	103	205	105	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXD
KCTD1	Q719H9	103	205	118	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXD
KCTD1	Q719H9	103	205	118	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXD
KCTD1	Q719H9	103	205	118	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXD
KCTD1	Q719H9	103	205	129	131	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXB
KCTD1	Q719H9	103	205	129	131	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXB
KCTD1	Q719H9	103	205	129	131	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BXB
KCNH4	Q9UQ05	398	463	1	1017	Chain	ID=PRO_0000054008;Note=Potassium voltage-gated channel subfamily H member 4
KCNH4	Q9UQ05	103	152	1	1017	Chain	ID=PRO_0000054008;Note=Potassium voltage-gated channel subfamily H member 4
KCNH4	Q9UQ05	398	463	1	1017	Chain	ID=PRO_0000054008;Note=Potassium voltage-gated channel subfamily H member 4
KCNH4	Q9UQ05	103	152	1	1017	Chain	ID=PRO_0000054008;Note=Potassium voltage-gated channel subfamily H member 4
KCNH4	Q9UQ05	103	152	1	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	103	152	1	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	383	427	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	383	427	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	428	448	Intramembrane	Note=Pore-forming%3B Name%3DSegment H5;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	428	448	Intramembrane	Note=Pore-forming%3B Name%3DSegment H5;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	449	482	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	449	482	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	103	152	93	145	Domain	Note=PAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00141
KCNH4	Q9UQ05	103	152	93	145	Domain	Note=PAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00141
KCNH4	Q9UQ05	398	463	439	444	Motif	Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250
KCNH4	Q9UQ05	398	463	439	444	Motif	Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250
KCNH4	Q9UQ05	398	463	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNH4	Q9UQ05	398	463	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDM3B	Q7LBC6	120	158	2	1761	Chain	ID=PRO_0000234373;Note=Lysine-specific demethylase 3B
KDM3B	Q7LBC6	235	260	2	1761	Chain	ID=PRO_0000234373;Note=Lysine-specific demethylase 3B
KDM3B	Q7LBC6	260	460	2	1761	Chain	ID=PRO_0000234373;Note=Lysine-specific demethylase 3B
KDM3B	Q7LBC6	1066	1102	2	1761	Chain	ID=PRO_0000234373;Note=Lysine-specific demethylase 3B
KDM3B	Q7LBC6	1324	1413	2	1761	Chain	ID=PRO_0000234373;Note=Lysine-specific demethylase 3B
KDM3B	Q7LBC6	1690	1735	2	1761	Chain	ID=PRO_0000234373;Note=Lysine-specific demethylase 3B
KDM3B	Q7LBC6	1690	1735	1498	1721	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM3B	Q7LBC6	260	460	361	361	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
KDM3B	Q7LBC6	120	158	1	1002	Alternative sequence	ID=VSP_018298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KDM3B	Q7LBC6	235	260	1	1002	Alternative sequence	ID=VSP_018298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KDM3B	Q7LBC6	260	460	1	1002	Alternative sequence	ID=VSP_018298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KDM3B	Q7LBC6	120	158	1	344	Alternative sequence	ID=VSP_018299;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11087669;Dbxref=PMID:11087669
KDM3B	Q7LBC6	235	260	1	344	Alternative sequence	ID=VSP_018299;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11087669;Dbxref=PMID:11087669
KDM3B	Q7LBC6	260	460	1	344	Alternative sequence	ID=VSP_018299;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11087669;Dbxref=PMID:11087669
KDM3B	Q7LBC6	260	460	345	349	Alternative sequence	ID=VSP_018300;Note=In isoform 2. TFVPQ->MGAME;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11087669;Dbxref=PMID:11087669
KDM3B	Q7LBC6	235	260	256	256	Natural variant	ID=VAR_026221;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:11687974,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.6;Dbxref=dbSNP:rs6865472,PMID:10470851,PMID:11687974,PMID:15489334
KDM3B	Q7LBC6	1324	1413	1382	1385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM3B	Q7LBC6	1324	1413	1386	1389	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM3B	Q7LBC6	1324	1413	1390	1394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM3B	Q7LBC6	1324	1413	1401	1410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM3B	Q7LBC6	1690	1735	1689	1704	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM3B	Q7LBC6	1690	1735	1707	1709	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM3B	Q7LBC6	1690	1735	1710	1719	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C8D
KDM5C	P41229	1146	1346	1	1560	Chain	ID=PRO_0000200586;Note=Lysine-specific demethylase 5C
KDM5C	P41229	622	687	1	1560	Chain	ID=PRO_0000200586;Note=Lysine-specific demethylase 5C
KDM5C	P41229	374	414	1	1560	Chain	ID=PRO_0000200586;Note=Lysine-specific demethylase 5C
KDM5C	P41229	76	117	1	1560	Chain	ID=PRO_0000200586;Note=Lysine-specific demethylase 5C
KDM5C	P41229	50	76	1	1560	Chain	ID=PRO_0000200586;Note=Lysine-specific demethylase 5C
KDM5C	P41229	50	76	14	55	Domain	Note=JmjN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00537
KDM5C	P41229	76	117	79	169	Domain	Note=ARID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00355
KDM5C	P41229	622	687	468	634	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM5C	P41229	1146	1346	1187	1248	Zinc finger	Note=PHD-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
KDM5C	P41229	76	117	51	76	Alternative sequence	ID=VSP_043752;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KDM5C	P41229	50	76	51	76	Alternative sequence	ID=VSP_043752;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KDM5C	P41229	76	117	77	117	Alternative sequence	ID=VSP_026410;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KDM5C	P41229	76	117	87	87	Natural variant	ID=VAR_032986;Note=In MRXSCJ%3B no effect on subcellular location and enzymatic activity. D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16541399,ECO:0000269|PubMed:17468742;Dbxref=PMID:16541399,PMID:17468742
KDM5C	P41229	374	414	388	388	Natural variant	ID=VAR_022730;Note=In MRXSCJ%3B impairs enzymatic activity and binding to H3-K9Me3. A->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15586325,ECO:0000269|PubMed:17320160;Dbxref=dbSNP:rs199422235,PMID:15586325,PMID:17320160
KDM5C	P41229	374	414	402	402	Natural variant	ID=VAR_022731;Note=In MRXSCJ%3B decreases enzymatic activity. D->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15586325,ECO:0000269|PubMed:17468742,ECO:0000269|PubMed:25666439;Dbxref=PMID:15586325,PMID:17468742,PMID:25666439
KDM5C	P41229	622	687	640	640	Natural variant	ID=VAR_065091;Note=De novo mutation found in a patient with mental retardation. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21076407;Dbxref=PMID:21076407
KDM5C	P41229	622	687	642	642	Natural variant	ID=VAR_032988;Note=In MRXSCJ%3B impairs enzymatic activity. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16541399,ECO:0000269|PubMed:17320160;Dbxref=PMID:16541399,PMID:17320160
KDM5C	P41229	1146	1346	1199	1199	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
KDM5C	P41229	76	117	73	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRZ
KDM5C	P41229	50	76	73	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRZ
KDM5C	P41229	76	117	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRZ
KDM5C	P41229	76	117	82	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRZ
KDM5C	P41229	76	117	95	97	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRZ
KDM5C	P41229	76	117	112	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRZ
KDM5C	P41229	374	414	394	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FWJ
KDM5C	P41229	622	687	620	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FWJ
KDM5C	P41229	622	687	623	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FWJ
KDM5C	P41229	622	687	644	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FWJ
KDM5C	P41229	622	687	655	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FWJ
KDM5C	P41229	622	687	660	687	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FWJ
KIF23	Q02241	465	518	1	960	Chain	ID=PRO_0000125434;Note=Kinesin-like protein KIF23
KIF23	Q02241	689	793	1	960	Chain	ID=PRO_0000125434;Note=Kinesin-like protein KIF23
KIF23	Q02241	793	877	1	960	Chain	ID=PRO_0000125434;Note=Kinesin-like protein KIF23
KIF23	Q02241	793	877	794	911	Region	Note=Interaction with ARF6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22522702;Dbxref=PMID:22522702
KIF23	Q02241	689	793	738	738	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
KIF23	Q02241	793	877	814	814	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
KIF23	Q02241	793	877	867	867	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:20068231,PMID:23186163
KIF23	Q02241	689	793	741	741	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
KIF23	Q02241	793	877	823	823	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KIF23	Q02241	793	877	854	854	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KIF23	Q02241	793	877	874	874	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KIF23	Q02241	793	877	877	877	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
KIF23	Q02241	689	793	690	793	Alternative sequence	ID=VSP_021801;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1406973,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:1406973,PMID:14702039,PMID:15489334
KIF23	Q02241	793	877	690	793	Alternative sequence	ID=VSP_021801;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1406973,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:1406973,PMID:14702039,PMID:15489334
KIF23	Q02241	465	518	515	515	Natural variant	ID=VAR_049686;Note=F->L;Dbxref=dbSNP:rs17310879
KIF23	Q02241	793	877	814	816	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIF23	Q02241	793	877	819	822	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIF23	Q02241	793	877	833	836	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIF23	Q02241	793	877	841	846	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIF23	Q02241	793	877	849	854	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIF23	Q02241	793	877	856	865	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIF23	Q02241	793	877	871	882	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHX
KIRREL3	Q8IZU9	517	529	22	778	Chain	ID=PRO_0000015098;Note=Kin of IRRE-like protein 3
KIRREL3	Q8IZU9	517	529	22	535	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TK1	P04183	131	171	2	234	Chain	ID=PRO_0000174948;Note=Thymidine kinase%2C cytosolic
TK1	P04183	131	171	153	153	Metal binding	Note=Zinc;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1W4R,ECO:0000244|PDB:1XBT,ECO:0000244|PDB:2ORV,ECO:0000244|PDB:2WVJ,ECO:0000269|PubMed:15611477,ECO:0000269|PubMed:15733844,ECO:0000269|PubMed:17407781,ECO:0000269|PubMed:22385435;Dbxref=PMID:15611477,PMID:15733844,PMID:17407781,PMID:22385435
TK1	P04183	131	171	156	156	Metal binding	Note=Zinc;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1W4R,ECO:0000244|PDB:1XBT,ECO:0000244|PDB:2ORV,ECO:0000244|PDB:2WVJ,ECO:0000269|PubMed:15611477,ECO:0000269|PubMed:15733844,ECO:0000269|PubMed:17407781,ECO:0000269|PubMed:22385435;Dbxref=PMID:15611477,PMID:15733844,PMID:17407781,PMID:22385435
TK1	P04183	131	171	163	163	Mutagenesis	Note=140-fold lower K(m) for AZT. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22385435;Dbxref=PMID:22385435
TK1	P04183	131	171	130	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W4R
TK1	P04183	131	171	136	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W4R
TK1	P04183	131	171	144	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W4R
TK1	P04183	131	171	154	156	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W4R
TK1	P04183	131	171	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W4R
TK1	P04183	131	171	162	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W4R
KLHDC1	Q8N7A1	161	189	1	406	Chain	ID=PRO_0000119126;Note=Kelch domain-containing protein 1
KLHDC1	Q8N7A1	189	217	1	406	Chain	ID=PRO_0000119126;Note=Kelch domain-containing protein 1
KLHDC1	Q8N7A1	161	189	135	181	Repeat	Note=Kelch 3
KLHDC1	Q8N7A1	189	217	208	258	Repeat	Note=Kelch 4
KLHDC4	Q8TBB5	169	199	1	520	Chain	ID=PRO_0000228998;Note=Kelch domain-containing protein 4
KLHDC4	Q8TBB5	169	199	133	187	Repeat	Note=Kelch 2
KLHDC4	Q8TBB5	169	199	188	241	Repeat	Note=Kelch 3
KLHDC4	Q8TBB5	169	199	170	200	Alternative sequence	ID=VSP_017729;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLHL20	Q9Y2M5	199	252	1	609	Chain	ID=PRO_0000119123;Note=Kelch-like protein 20
KLHL20	Q9Y2M5	384	431	1	609	Chain	ID=PRO_0000119123;Note=Kelch-like protein 20
KLHL20	Q9Y2M5	199	252	170	272	Domain	Note=BACK
KLHL20	Q9Y2M5	384	431	367	413	Repeat	Note=Kelch 2
KLHL20	Q9Y2M5	384	431	414	460	Repeat	Note=Kelch 3
KLHL20	Q9Y2M5	199	252	11	199	Alternative sequence	ID=VSP_057027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLHL20	Q9Y2M5	384	431	396	396	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRKCQ	Q04759	612	655	1	706	Chain	ID=PRO_0000055708;Note=Protein kinase C theta type
PRKCQ	Q04759	549	612	1	706	Chain	ID=PRO_0000055708;Note=Protein kinase C theta type
PRKCQ	Q04759	482	502	1	706	Chain	ID=PRO_0000055708;Note=Protein kinase C theta type
PRKCQ	Q04759	612	655	380	634	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCQ	Q04759	549	612	380	634	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCQ	Q04759	482	502	380	634	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCQ	Q04759	612	655	635	706	Domain	Note=AGC-kinase C-terminal
PRKCQ	Q04759	612	655	550	612	Alternative sequence	ID=VSP_017294;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
PRKCQ	Q04759	549	612	550	612	Alternative sequence	ID=VSP_017294;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
PRKCQ	Q04759	482	502	478	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	549	612	548	551	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	549	612	559	574	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	549	612	584	593	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	612	655	604	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	549	612	604	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	612	655	618	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	612	655	628	630	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	612	655	632	634	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
PRKCQ	Q04759	612	655	639	643	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJD
ITPKC	Q96DU7	592	616	1	683	Chain	ID=PRO_0000234070;Note=Inositol-trisphosphate 3-kinase C
ITPKC	Q96DU7	592	616	589	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A98
ITPKC	Q96DU7	592	616	610	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A98
ITPKC	Q96DU7	592	616	615	617	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A98
PPA1	Q15181	99	128	2	289	Chain	ID=PRO_0000137567;Note=Inorganic pyrophosphatase
PPA1	Q15181	41	59	2	289	Chain	ID=PRO_0000137567;Note=Inorganic pyrophosphatase
PPA1	Q15181	99	128	116	116	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPA1	Q15181	99	128	121	121	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPA1	Q15181	99	128	121	121	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPA1	Q15181	41	59	57	57	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PPA1	Q15181	41	59	57	57	Natural variant	ID=VAR_036358;Note=In a breast cancer sample%3B somatic mutation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
PPA1	Q15181	99	128	105	114	Sequence conflict	Note=GHNDKHTGCC->HEKDKSTNCF;Ontology_term=ECO:0000305;evidence=ECO:0000305
MIOX	Q9UGB7	32	59	1	285	Chain	ID=PRO_0000079148;Note=Inositol oxygenase
MIOX	Q9UGB7	32	59	33	33	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXN4
MIOX	Q9UGB7	32	59	38	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IBN
MIOX	Q9UGB7	32	59	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IBN
MIPEP	Q99797	551	576	36	713	Chain	ID=PRO_0000028579;Note=Mitochondrial intermediate peptidase
MIPEP	Q99797	420	446	36	713	Chain	ID=PRO_0000028579;Note=Mitochondrial intermediate peptidase
MIPOL1	Q8TD10	276	312	1	442	Chain	ID=PRO_0000096490;Note=Mirror-image polydactyly gene 1 protein
MIPOL1	Q8TD10	344	420	1	442	Chain	ID=PRO_0000096490;Note=Mirror-image polydactyly gene 1 protein
MIPOL1	Q8TD10	276	312	1	442	Chain	ID=PRO_0000096490;Note=Mirror-image polydactyly gene 1 protein
MIPOL1	Q8TD10	344	420	1	442	Chain	ID=PRO_0000096490;Note=Mirror-image polydactyly gene 1 protein
MIPOL1	Q8TD10	276	312	1	442	Chain	ID=PRO_0000096490;Note=Mirror-image polydactyly gene 1 protein
MIPOL1	Q8TD10	344	420	1	442	Chain	ID=PRO_0000096490;Note=Mirror-image polydactyly gene 1 protein
MIPOL1	Q8TD10	276	312	253	435	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MIPOL1	Q8TD10	344	420	253	435	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MIPOL1	Q8TD10	276	312	253	435	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MIPOL1	Q8TD10	344	420	253	435	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MIPOL1	Q8TD10	276	312	253	435	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MIPOL1	Q8TD10	344	420	253	435	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MIPOL1	Q8TD10	276	312	170	442	Alternative sequence	ID=VSP_009462;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MIPOL1	Q8TD10	344	420	170	442	Alternative sequence	ID=VSP_009462;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MIPOL1	Q8TD10	276	312	170	442	Alternative sequence	ID=VSP_009462;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MIPOL1	Q8TD10	344	420	170	442	Alternative sequence	ID=VSP_009462;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MIPOL1	Q8TD10	276	312	170	442	Alternative sequence	ID=VSP_009462;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MIPOL1	Q8TD10	344	420	170	442	Alternative sequence	ID=VSP_009462;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAF3IP1	Q8TDR0	41	64	1	691	Chain	ID=PRO_0000299544;Note=TRAF3-interacting protein 1
TRAF3IP1	Q8TDR0	305	329	1	691	Chain	ID=PRO_0000299544;Note=TRAF3-interacting protein 1
TRAF3IP1	Q8TDR0	354	386	1	691	Chain	ID=PRO_0000299544;Note=TRAF3-interacting protein 1
TRAF3IP1	Q8TDR0	386	420	1	691	Chain	ID=PRO_0000299544;Note=TRAF3-interacting protein 1
TRAF3IP1	Q8TDR0	41	64	1	323	Region	Note=Abolishes microtubules-binding when missing
TRAF3IP1	Q8TDR0	305	329	1	323	Region	Note=Abolishes microtubules-binding when missing
TRAF3IP1	Q8TDR0	305	329	223	691	Region	Note=DISC1-interaction domain
TRAF3IP1	Q8TDR0	354	386	223	691	Region	Note=DISC1-interaction domain
TRAF3IP1	Q8TDR0	386	420	223	691	Region	Note=DISC1-interaction domain
TRAF3IP1	Q8TDR0	305	329	317	317	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q149C2
TRAF3IP1	Q8TDR0	354	386	355	420	Alternative sequence	ID=VSP_027734;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10791955,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:10791955,PMID:15489334,PMID:17974005
TRAF3IP1	Q8TDR0	386	420	355	420	Alternative sequence	ID=VSP_027734;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10791955,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:10791955,PMID:15489334,PMID:17974005
TRAF3IP1	Q8TDR0	386	420	416	416	Natural variant	ID=VAR_061685;Note=T->S;Dbxref=dbSNP:rs58277463
TRAF3IP1	Q8TDR0	41	64	32	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQO
TRAF3IP1	Q8TDR0	41	64	50	52	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQO
TRAF3IP1	Q8TDR0	41	64	55	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQO
TRAF3IP1	Q8TDR0	41	64	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQO
ITGA3	P26006	800	861	33	1051	Chain	ID=PRO_0000016238;Note=Integrin alpha-3
ITGA3	P26006	800	861	33	872	Chain	ID=PRO_0000016239;Note=Integrin alpha-3 heavy chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA3	P26006	800	861	33	991	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA3	P26006	800	861	841	841	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA3	P26006	800	861	857	857	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA3	P26006	800	861	846	904	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14596610;Dbxref=PMID:14596610
ITGA3	P26006	800	861	840	840	Natural variant	ID=VAR_055969;Note=G->S;Dbxref=dbSNP:rs2301626
ITGB7	P26010	325	357	20	798	Chain	ID=PRO_0000016352;Note=Integrin beta-7
ITGB7	P26010	325	357	20	798	Chain	ID=PRO_0000016352;Note=Integrin beta-7
ITGB7	P26010	325	357	20	723	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB7	P26010	325	357	20	723	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB7	P26010	325	357	150	389	Domain	Note=VWFA
ITGB7	P26010	325	357	150	389	Domain	Note=VWFA
ITGB7	P26010	325	357	45	476	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB7	P26010	325	357	45	476	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB7	P26010	325	357	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	342	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	342	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	353	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
ITGB7	P26010	325	357	353	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V4V
MLC1	Q15049	298	353	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	238	257	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	107	141	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	89	107	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	59	89	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	298	353	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	238	257	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	107	141	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	89	107	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	59	89	2	377	Chain	ID=PRO_0000096496;Note=Membrane protein MLC1
MLC1	Q15049	59	89	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	59	89	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	89	107	82	100	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	59	89	82	100	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	89	107	82	100	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	59	89	82	100	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	107	141	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	107	141	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	238	257	230	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	238	257	230	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	238	257	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	238	257	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	298	353	304	324	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	298	353	304	324	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLC1	Q15049	89	107	60	89	Alternative sequence	ID=VSP_055494;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLC1	Q15049	59	89	60	89	Alternative sequence	ID=VSP_055494;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLC1	Q15049	89	107	60	89	Alternative sequence	ID=VSP_055494;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLC1	Q15049	59	89	60	89	Alternative sequence	ID=VSP_055494;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLC1	Q15049	59	89	59	59	Natural variant	ID=VAR_017438;Note=In MLC1. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12189496;Dbxref=dbSNP:rs80358242,PMID:12189496
MLC1	Q15049	59	89	59	59	Natural variant	ID=VAR_017438;Note=In MLC1. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12189496;Dbxref=dbSNP:rs80358242,PMID:12189496
MLC1	Q15049	59	89	69	69	Natural variant	ID=VAR_067762;Note=In MLC1. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875309,PMID:16652334
MLC1	Q15049	59	89	69	69	Natural variant	ID=VAR_067762;Note=In MLC1. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875309,PMID:16652334
MLC1	Q15049	59	89	80	80	Natural variant	ID=VAR_067763;Note=In MLC1. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875310,PMID:16652334
MLC1	Q15049	59	89	80	80	Natural variant	ID=VAR_067763;Note=In MLC1. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875310,PMID:16652334
MLC1	Q15049	59	89	84	84	Natural variant	ID=VAR_067764;Note=In MLC1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875311,PMID:16652334
MLC1	Q15049	59	89	84	84	Natural variant	ID=VAR_067764;Note=In MLC1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875311,PMID:16652334
MLC1	Q15049	89	107	92	92	Natural variant	ID=VAR_017439;Note=In MLC1. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11935341;Dbxref=dbSNP:rs121908345,PMID:11935341
MLC1	Q15049	89	107	92	92	Natural variant	ID=VAR_017439;Note=In MLC1. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11935341;Dbxref=dbSNP:rs121908345,PMID:11935341
MLC1	Q15049	89	107	93	93	Natural variant	ID=VAR_011699;Note=In MLC1. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11254442;Dbxref=dbSNP:rs80358245,PMID:11254442
MLC1	Q15049	89	107	93	93	Natural variant	ID=VAR_011699;Note=In MLC1. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11254442;Dbxref=dbSNP:rs80358245,PMID:11254442
MLC1	Q15049	107	141	118	118	Natural variant	ID=VAR_011700;Note=In MLC1. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11254442;Dbxref=dbSNP:rs281875316,PMID:11254442
MLC1	Q15049	107	141	118	118	Natural variant	ID=VAR_011700;Note=In MLC1. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11254442;Dbxref=dbSNP:rs281875316,PMID:11254442
MLC1	Q15049	107	141	125	125	Natural variant	ID=VAR_067765;Note=In MLC1%3B accumulates in the cytoplasmic perinuclear region and endoplasmic reticulum%3B affects interaction with ATP1B1. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11935341,ECO:0000269|PubMed:22328087;Dbxref=dbSNP:rs281875314,PMID:11935341,PMID:22328087
MLC1	Q15049	107	141	125	125	Natural variant	ID=VAR_067765;Note=In MLC1%3B accumulates in the cytoplasmic perinuclear region and endoplasmic reticulum%3B affects interaction with ATP1B1. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11935341,ECO:0000269|PubMed:22328087;Dbxref=dbSNP:rs281875314,PMID:11935341,PMID:22328087
MLC1	Q15049	107	141	141	141	Natural variant	ID=VAR_017440;Note=In MLC1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11935341;Dbxref=dbSNP:rs121908343,PMID:11935341
MLC1	Q15049	107	141	141	141	Natural variant	ID=VAR_017440;Note=In MLC1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11935341;Dbxref=dbSNP:rs121908343,PMID:11935341
MLC1	Q15049	107	141	141	141	Natural variant	ID=VAR_017441;Note=In MLC1. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11935341;Dbxref=dbSNP:rs121908344,PMID:11935341
MLC1	Q15049	107	141	141	141	Natural variant	ID=VAR_017441;Note=In MLC1. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11935341;Dbxref=dbSNP:rs121908344,PMID:11935341
MLC1	Q15049	238	257	245	245	Natural variant	ID=VAR_067766;Note=In MLC1. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875312,PMID:16652334
MLC1	Q15049	238	257	245	245	Natural variant	ID=VAR_067766;Note=In MLC1. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875312,PMID:16652334
MLC1	Q15049	238	257	246	246	Natural variant	ID=VAR_067767;Note=In MLC1%3B does not affect subcellular location. S->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11935341,ECO:0000269|PubMed:22328087;Dbxref=dbSNP:rs281875315,PMID:11935341,PMID:22328087
MLC1	Q15049	238	257	246	246	Natural variant	ID=VAR_067767;Note=In MLC1%3B does not affect subcellular location. S->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11935341,ECO:0000269|PubMed:22328087;Dbxref=dbSNP:rs281875315,PMID:11935341,PMID:22328087
MLC1	Q15049	298	353	309	309	Natural variant	ID=VAR_012731;Note=In a pedigree affected by schizophrenia. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11326298;Dbxref=dbSNP:rs80358240,PMID:11326298
MLC1	Q15049	298	353	309	309	Natural variant	ID=VAR_012731;Note=In a pedigree affected by schizophrenia. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11326298;Dbxref=dbSNP:rs80358240,PMID:11326298
MLC1	Q15049	298	353	320	320	Natural variant	ID=VAR_067768;Note=In MLC1. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875313,PMID:16652334
MLC1	Q15049	298	353	320	320	Natural variant	ID=VAR_067768;Note=In MLC1. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16652334;Dbxref=dbSNP:rs281875313,PMID:16652334
MLC1	Q15049	298	353	344	344	Natural variant	ID=VAR_051187;Note=N->S;Dbxref=dbSNP:rs11568188
MLC1	Q15049	298	353	344	344	Natural variant	ID=VAR_051187;Note=N->S;Dbxref=dbSNP:rs11568188
JARID2	Q92833	164	223	1	1246	Chain	ID=PRO_0000200591;Note=Protein Jumonji
JARID2	Q92833	984	1045	1	1246	Chain	ID=PRO_0000200591;Note=Protein Jumonji
JARID2	Q92833	984	1045	884	1048	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JARID2	Q92833	164	223	1	172	Alternative sequence	ID=VSP_045041;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
JARID2	Q92833	984	1045	949	1246	Alternative sequence	ID=VSP_038757;Note=In isoform 2. WYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS->CLSVEPVFPHLSVAVGSIVDLGISFLPCGDTRVMYPVESVAWRGVLGPRL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
JOSD1	Q15040	105	169	1	202	Chain	ID=PRO_0000053839;Note=Josephin-1
JOSD1	Q15040	105	169	23	202	Domain	Note=Josephin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00331
JOSD1	Q15040	105	169	139	139	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00331
KIAA0513	O60268	327	336	1	411	Chain	ID=PRO_0000050757;Note=Uncharacterized protein KIAA0513
KIAA0513	O60268	327	336	1	411	Chain	ID=PRO_0000050757;Note=Uncharacterized protein KIAA0513
KIAA0513	O60268	327	336	302	411	Alternative sequence	ID=VSP_011551;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA0513	O60268	327	336	302	411	Alternative sequence	ID=VSP_011551;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA0513	O60268	327	336	327	336	Alternative sequence	ID=VSP_054680;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA0513	O60268	327	336	327	336	Alternative sequence	ID=VSP_054680;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA1324L	A8MWY0	665	723	48	1029	Chain	ID=PRO_0000333798;Note=UPF0577 protein KIAA1324-like
KIAA1324L	A8MWY0	531	577	48	1029	Chain	ID=PRO_0000333798;Note=UPF0577 protein KIAA1324-like
KIAA1324L	A8MWY0	282	333	48	1029	Chain	ID=PRO_0000333798;Note=UPF0577 protein KIAA1324-like
KIAA1324L	A8MWY0	665	723	48	929	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324L	A8MWY0	531	577	48	929	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324L	A8MWY0	282	333	48	929	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324L	A8MWY0	665	723	691	691	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324L	A8MWY0	282	333	293	310	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
KIAA1324L	A8MWY0	282	333	323	346	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
KIAA1324L	A8MWY0	282	333	326	358	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
KIAA1324L	A8MWY0	531	577	539	539	Natural variant	ID=VAR_043161;Note=N->Y;Dbxref=dbSNP:rs1029366
KIAA1324L	A8MWY0	665	723	678	678	Sequence conflict	Note=H->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIAA0895	Q8NCT3	333	435	1	520	Chain	ID=PRO_0000320617;Note=Uncharacterized protein KIAA0895
KIAA0895	Q8NCT3	333	435	290	520	Alternative sequence	ID=VSP_031687;Note=In isoform 4. IVVHLTEDLLSRASMTVVNGCPTLTINVSTAREHWLEGMLRHEIGTHYFRGINNLQQPWNSWTGRKKHELKPNNPTEEGLASIHSVLFRKDPFLWRAALLYYTVYQASQMSFCELFKDIGRFVKDPNTRWDYCVRAKRGWTDTSQPGCFSKDQVYLDGILQILRYRDTIDFHLLTALGKVSYEDVDRLKGLAVTENMRVPHFLQDHGRYMEHLEKIMEVNELTDRELKDLI->VKCHFNSGSSFLCTKTIICDLISKNKDI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA1586	Q9HCI6	35	62	1	787	Chain	ID=PRO_0000320680;Note=E3 SUMO-protein ligase KIAA1586
KIAA1586	Q9HCI6	35	62	1	223	Region	Note=Sufficient for E3 SUMO-protein ligase activity;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIAA1586	Q9HCI6	35	62	30	37	Region	Note=Interaction with SUMO2 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4E5
KIAA1586	Q9HCI6	35	62	42	50	Region	Note=Interaction with SUMO2 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4E5
KIAA1586	Q9HCI6	35	62	38	41	Motif	Note=PSRP;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIAA1586	Q9HCI6	35	62	1	62	Alternative sequence	ID=VSP_031740;Note=In isoform 2. MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYYSD->MNFTYICKIIFQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
KRT16	P08779	311	353	1	473	Chain	ID=PRO_0000063662;Note=Keratin%2C type I cytoskeletal 16
KRT16	P08779	311	353	117	428	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT16	P08779	311	353	286	424	Region	Note=Coil 2
KRT16	P08779	311	353	352	352	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMP9	P14780	173	216	107	707	Chain	ID=PRO_0000028756;Note=82 kDa matrix metalloproteinase-9
MMP9	P14780	391	443	107	707	Chain	ID=PRO_0000028756;Note=82 kDa matrix metalloproteinase-9
MMP9	P14780	391	443	402	402	Active site	.
MMP9	P14780	173	216	175	175	Metal binding	Note=Zinc 1%3B structural;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	173	216	177	177	Metal binding	Note=Zinc 1%3B structural;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	173	216	182	182	Metal binding	Note=Calcium 3
MMP9	P14780	173	216	183	183	Metal binding	Note=Calcium 3%3B via carbonyl oxygen
MMP9	P14780	173	216	185	185	Metal binding	Note=Calcium 3%3B via carbonyl oxygen
MMP9	P14780	173	216	187	187	Metal binding	Note=Calcium 3%3B via carbonyl oxygen
MMP9	P14780	173	216	190	190	Metal binding	Note=Zinc 1%3B structural;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	173	216	197	197	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
MMP9	P14780	173	216	199	199	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
MMP9	P14780	173	216	201	201	Metal binding	Note=Calcium 2
MMP9	P14780	173	216	203	203	Metal binding	Note=Zinc 1%3B structural;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	173	216	205	205	Metal binding	Note=Calcium 3
MMP9	P14780	173	216	206	206	Metal binding	Note=Calcium 1
MMP9	P14780	173	216	208	208	Metal binding	Note=Calcium 1
MMP9	P14780	173	216	208	208	Metal binding	Note=Calcium 3
MMP9	P14780	391	443	401	401	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	391	443	405	405	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	391	443	411	411	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051944,ECO:0000269|PubMed:12077439;Dbxref=PMID:12051944,PMID:12077439
MMP9	P14780	391	443	402	402	Mutagenesis	Note=Loss of activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12051944;Dbxref=PMID:12051944
MMP9	P14780	173	216	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	173	216	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	173	216	189	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	173	216	194	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	173	216	197	200	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	173	216	202	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	173	216	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ESM
MMP9	P14780	391	443	392	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XCT
MMP9	P14780	391	443	395	406	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XCT
MMP9	P14780	391	443	420	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XCT
MMP9	P14780	391	443	427	429	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2E
MMP9	P14780	391	443	433	443	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XCT
KRT6A	P02538	359	401	2	564	Chain	ID=PRO_0000063731;Note=Keratin%2C type II cytoskeletal 6A
KRT6A	P02538	272	304	2	564	Chain	ID=PRO_0000063731;Note=Keratin%2C type II cytoskeletal 6A
KRT6A	P02538	359	401	163	476	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT6A	P02538	272	304	163	476	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT6A	P02538	272	304	218	309	Region	Note=Coil 1B
KRT6A	P02538	359	401	334	472	Region	Note=Coil 2
KRT6A	P02538	359	401	395	395	Sequence conflict	Note=I->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KRT6C	P48668	359	401	2	564	Chain	ID=PRO_0000063735;Note=Keratin%2C type II cytoskeletal 6C
KRT6C	P48668	272	304	2	564	Chain	ID=PRO_0000063735;Note=Keratin%2C type II cytoskeletal 6C
KRT6C	P48668	359	401	163	476	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT6C	P48668	272	304	163	476	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT6C	P48668	272	304	218	309	Region	Note=Coil 1B
KRT6C	P48668	359	401	334	472	Region	Note=Coil 2
KRT72	Q14CN4	321	363	1	511	Chain	ID=PRO_0000314877;Note=Keratin%2C type II cytoskeletal 72
KRT72	Q14CN4	321	363	1	511	Chain	ID=PRO_0000314877;Note=Keratin%2C type II cytoskeletal 72
KRT72	Q14CN4	321	363	125	438	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT72	Q14CN4	321	363	125	438	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT72	Q14CN4	321	363	296	434	Region	Note=Coil 2
KRT72	Q14CN4	321	363	296	434	Region	Note=Coil 2
KRT72	Q14CN4	321	363	322	363	Alternative sequence	ID=VSP_045280;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KRT72	Q14CN4	321	363	322	363	Alternative sequence	ID=VSP_045280;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KRT72	Q14CN4	321	363	363	363	Alternative sequence	ID=VSP_030416;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11703281;Dbxref=PMID:11703281
KRT72	Q14CN4	321	363	363	363	Alternative sequence	ID=VSP_030416;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11703281;Dbxref=PMID:11703281
KRT72	Q14CN4	321	363	326	326	Natural variant	ID=VAR_061298;Note=Q->E;Dbxref=dbSNP:rs34769047
KRT72	Q14CN4	321	363	326	326	Natural variant	ID=VAR_061298;Note=Q->E;Dbxref=dbSNP:rs34769047
KRT73	Q86Y46	241	273	1	540	Chain	ID=PRO_0000314881;Note=Keratin%2C type II cytoskeletal 73
KRT73	Q86Y46	241	273	132	445	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT73	Q86Y46	241	273	187	278	Region	Note=Coil 1B
KRT73	Q86Y46	241	273	248	248	Natural variant	ID=VAR_038094;Note=In a colorectal cancer sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs142246988,PMID:16959974
CAMK2D	Q13557	53	73	2	499	Chain	ID=PRO_0000086099;Note=Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK2D	Q13557	53	73	14	272	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CAMK2D	Q13557	53	73	52	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEL
CMPK1	P30085	106	157	1	196	Chain	ID=PRO_0000158949;Note=UMP-CMP kinase
CMPK1	P30085	106	157	133	143	Region	Note=LID;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15163660;Dbxref=PMID:15163660
CMPK1	P30085	106	157	134	134	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03172
CMPK1	P30085	106	157	140	140	Binding site	Note=NMP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03172
CMPK1	P30085	106	157	151	151	Binding site	Note=NMP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03172
CMPK1	P30085	106	157	106	106	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBP5
CMPK1	P30085	106	157	98	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TEV
CMPK1	P30085	106	157	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TEV
CMPK1	P30085	106	157	113	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TEV
CMPK1	P30085	106	157	124	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TEV
CMPK1	P30085	106	157	145	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TEV
KDM3A	Q9Y4C1	62	114	1	1321	Chain	ID=PRO_0000084285;Note=Lysine-specific demethylase 3A
KDM3A	Q9Y4C1	62	114	1	1321	Chain	ID=PRO_0000084285;Note=Lysine-specific demethylase 3A
KDM3A	Q9Y4C1	62	114	1	1321	Chain	ID=PRO_0000084285;Note=Lysine-specific demethylase 3A
KDM5A	P29375	551	591	1	1690	Chain	ID=PRO_0000200584;Note=Lysine-specific demethylase 5A
KDM5A	P29375	81	122	1	1690	Chain	ID=PRO_0000200584;Note=Lysine-specific demethylase 5A
KDM5A	P29375	81	122	84	174	Domain	Note=ARID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00355
KDM5A	P29375	551	591	437	603	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM5A	P29375	551	591	571	571	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000255,ECO:0000305,ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00538,ECO:0000305|PubMed:26645689,ECO:0000305|PubMed:27214401,ECO:0000305|PubMed:27427228,ECO:0000305|PubMed:27499454;Dbxref=PMID:26645689,PMID:27214401,PMID:27427228,PMID:27499454
KDM5A	P29375	81	122	112	112	Mutagenesis	Note=Decreases DNA-binding. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270511;Dbxref=PMID:18270511
KDM5A	P29375	81	122	77	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BGY
KDM5A	P29375	81	122	85	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V9P
KDM5A	P29375	81	122	117	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V9P
KDM5A	P29375	551	591	553	557	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BGY
KDM5A	P29375	551	591	562	565	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BGY
KDM5A	P29375	551	591	570	586	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BGY
KDM5A	P29375	551	591	589	591	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V9P
KDM5B	Q9UGL1	607	672	1	1544	Chain	ID=PRO_0000292412;Note=Lysine-specific demethylase 5B
KDM5B	Q9UGL1	567	607	1	1544	Chain	ID=PRO_0000292412;Note=Lysine-specific demethylase 5B
KDM5B	Q9UGL1	359	399	1	1544	Chain	ID=PRO_0000292412;Note=Lysine-specific demethylase 5B
KDM5B	Q9UGL1	306	359	1	1544	Chain	ID=PRO_0000292412;Note=Lysine-specific demethylase 5B
KDM5B	Q9UGL1	192	237	1	1544	Chain	ID=PRO_0000292412;Note=Lysine-specific demethylase 5B
KDM5B	Q9UGL1	94	135	1	1544	Chain	ID=PRO_0000292412;Note=Lysine-specific demethylase 5B
KDM5B	Q9UGL1	94	135	97	187	Domain	Note=ARID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00355
KDM5B	Q9UGL1	607	672	453	619	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM5B	Q9UGL1	567	607	453	619	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
KDM5B	Q9UGL1	359	399	309	359	Zinc finger	Note=PHD-type 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2MNY,ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	309	359	Zinc finger	Note=PHD-type 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2MNY,ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	567	607	587	587	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:26741168,ECO:0000305|PubMed:27214403,ECO:0000305|PubMed:28262558;Dbxref=PMID:26741168,PMID:27214403,PMID:28262558
KDM5B	Q9UGL1	192	237	204	204	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KDM5B	Q9UGL1	192	237	209	209	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KDM5B	Q9UGL1	192	237	237	237	Alternative sequence	ID=VSP_026408;Note=In isoform 2. E->ERQSLAVLPRLECSGAILAHCNLRLLDSSNSSASASQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10616211;Dbxref=PMID:10616211
KDM5B	Q9UGL1	306	359	308	308	Mutagenesis	Note=Slightly decreases interaction with histone H3. Decreases by 21%25 demethylase activity and repression of tumor suppressor genes expression. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	309	309	Mutagenesis	Note=No effect on interaction with histone H3. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	310	310	Mutagenesis	Note=Slightly decreases interaction with histone H3. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	310	310	Mutagenesis	Note=No effect on interaction with histone H3. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	311	311	Mutagenesis	Note=No effect on interaction with histone H3. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	321	321	Mutagenesis	Note=Decreases interaction with histone H3. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	322	322	Mutagenesis	Note=No effect on interaction with histone H3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	324	324	Mutagenesis	Note=No effect on interaction with histone H3. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	325	325	Mutagenesis	Note=Abolishes interaction with histone H3. Decreases by 44%25 demethylase activity and repression of tumor suppressor genes expression%3B when associated with A-328. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	326	326	Mutagenesis	Note=No effect on interaction with histone H3. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	328	328	Mutagenesis	Note=Almost abolishes interaction with histone H3. Decreases by 44%25 demethylase activity and repression of tumor suppressor genes expression%3B when associated with A-325. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	332	332	Mutagenesis	Note=No effect on interaction with histone H3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	333	333	Mutagenesis	Note=No effect on interaction with histone H3. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	334	334	Mutagenesis	Note=No effect on interaction with histone H3. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	335	335	Mutagenesis	Note=Slightly impairs transcription repression ability. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17373667;Dbxref=PMID:17373667
KDM5B	Q9UGL1	306	359	345	345	Mutagenesis	Note=No effect on interaction with histone H3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	306	359	351	351	Mutagenesis	Note=Abolishes interaction with histone H3. Decreases by 28%25 demethylase activity and repression of tumor suppressor genes expression. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24952722;Dbxref=PMID:24952722
KDM5B	Q9UGL1	567	607	585	589	Sequence conflict	Note=AYHSG->VPQW;Ontology_term=ECO:0000305;evidence=ECO:0000305
KDM5B	Q9UGL1	94	135	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIU
KDM5B	Q9UGL1	306	359	308	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNY
KDM5B	Q9UGL1	306	359	313	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNZ
KDM5B	Q9UGL1	306	359	319	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNY
KDM5B	Q9UGL1	306	359	324	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNY
KDM5B	Q9UGL1	306	359	328	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNY
KDM5B	Q9UGL1	306	359	333	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNY
KDM5B	Q9UGL1	306	359	336	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MNY
KDM5B	Q9UGL1	359	399	358	360	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EK6
KDM5B	Q9UGL1	306	359	358	360	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EK6
KDM5B	Q9UGL1	359	399	363	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EK6
KDM5B	Q9UGL1	359	399	379	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	359	399	398	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	567	607	569	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	567	607	578	581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	567	607	587	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	607	672	605	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	567	607	605	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	607	672	608	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	607	672	629	637	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	607	672	638	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM5B	Q9UGL1	607	672	645	671	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FYZ
KDM6A	O15550	292	324	1	1401	Chain	ID=PRO_0000106409;Note=Lysine-specific demethylase 6A
KDM6A	O15550	398	443	1	1401	Chain	ID=PRO_0000106409;Note=Lysine-specific demethylase 6A
KDM6A	O15550	475	509	1	1401	Chain	ID=PRO_0000106409;Note=Lysine-specific demethylase 6A
KDM6A	O15550	292	324	284	317	Repeat	Note=TPR 6
KDM6A	O15550	292	324	318	351	Repeat	Note=TPR 7
KDM6A	O15550	292	324	1	1095	Region	Note=Interaction with SUPT6H;Ontology_term=ECO:0000250;evidence=ECO:0000250
KDM6A	O15550	398	443	1	1095	Region	Note=Interaction with SUPT6H;Ontology_term=ECO:0000250;evidence=ECO:0000250
KDM6A	O15550	475	509	1	1095	Region	Note=Interaction with SUPT6H;Ontology_term=ECO:0000250;evidence=ECO:0000250
KDM6A	O15550	475	509	497	497	Natural variant	ID=VAR_014493;Note=Q->H;Dbxref=dbSNP:rs6530
KDM6B	O15054	237	303	1	1643	Chain	ID=PRO_0000292007;Note=Lysine-specific demethylase 6B
KDM6B	O15054	237	303	195	906	Compositional bias	Note=Pro-rich
KDM6B	O15054	237	303	252	254	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KDM6B	O15054	237	303	252	254	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFMID	Q63HM1	51	86	1	303	Chain	ID=PRO_0000248308;Note=Kynurenine formamidase
AFMID	Q63HM1	260	295	1	303	Chain	ID=PRO_0000248308;Note=Kynurenine formamidase
AFMID	Q63HM1	260	295	279	279	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03014
AFMID	Q63HM1	260	295	260	260	Alternative sequence	ID=VSP_038002;Note=In isoform 2. Q->QVLPVQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MOCOS	Q96EN8	100	313	1	888	Chain	ID=PRO_0000249952;Note=Molybdenum cofactor sulfurase
MOCOS	Q96EN8	406	445	1	888	Chain	ID=PRO_0000249952;Note=Molybdenum cofactor sulfurase
MOCOS	Q96EN8	445	599	1	888	Chain	ID=PRO_0000249952;Note=Molybdenum cofactor sulfurase
MOCOS	Q96EN8	406	445	424	424	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03050
MOCOS	Q96EN8	100	313	264	264	Modified residue	Note=N6-(pyridoxal phosphate)lysine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03050
MOCOS	Q96EN8	445	599	528	528	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
MOCOS	Q96EN8	445	599	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
MOCOS	Q96EN8	100	313	120	120	Natural variant	ID=VAR_027529;Note=S->N;Dbxref=dbSNP:rs3744900
MOCOS	Q96EN8	100	313	170	170	Natural variant	ID=VAR_027530;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs623053,PMID:14702039,PMID:15489334
MOCOS	Q96EN8	100	313	184	184	Natural variant	ID=VAR_027531;Note=S->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs540967,PMID:14702039,PMID:15489334,PMID:17974005
MOCOS	Q96EN8	100	313	225	225	Natural variant	ID=VAR_027532;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11302742,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs623558,PMID:11302742,PMID:14702039,PMID:15489334,PMID:17974005
MOCOS	Q96EN8	100	313	294	294	Natural variant	ID=VAR_027533;Note=In XAN2. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12;Dbxref=dbSNP:rs577279030
MOCOS	Q96EN8	445	599	495	495	Natural variant	ID=VAR_027535;Note=D->N;Dbxref=dbSNP:rs8088347
MOCOS	Q96EN8	445	599	541	541	Natural variant	ID=VAR_027536;Note=V->L;Dbxref=dbSNP:rs672924
MOCOS	Q96EN8	100	313	119	119	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
KLC3	Q6P597	289	323	1	504	Chain	ID=PRO_0000230785;Note=Kinesin light chain 3
KLC3	Q6P597	289	323	291	324	Repeat	Note=TPR 3
MAP2K5	Q13163	324	348	1	448	Chain	ID=PRO_0000086383;Note=Dual specificity mitogen-activated protein kinase kinase 5
MAP2K5	Q13163	348	358	1	448	Chain	ID=PRO_0000086383;Note=Dual specificity mitogen-activated protein kinase kinase 5
MAP2K5	Q13163	324	348	166	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K5	Q13163	348	358	166	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K5	Q13163	348	358	349	358	Alternative sequence	ID=VSP_021825;Note=In isoform A and isoform C. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7759517,ECO:0000303|PubMed:9384584;Dbxref=PMID:7759517,PMID:9384584
PRKD2	Q9BZL6	657	690	1	878	Chain	ID=PRO_0000055716;Note=Serine/threonine-protein kinase D2
PRKD2	Q9BZL6	296	322	1	878	Chain	ID=PRO_0000055716;Note=Serine/threonine-protein kinase D2
PRKD2	Q9BZL6	657	690	1	878	Chain	ID=PRO_0000055716;Note=Serine/threonine-protein kinase D2
PRKD2	Q9BZL6	296	322	1	878	Chain	ID=PRO_0000055716;Note=Serine/threonine-protein kinase D2
PRKD2	Q9BZL6	657	690	551	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKD2	Q9BZL6	657	690	551	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKD2	Q9BZL6	296	322	264	314	Zinc finger	Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
PRKD2	Q9BZL6	296	322	264	314	Zinc finger	Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
PRKD2	Q9BZL6	657	690	674	674	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
PRKD2	Q9BZL6	657	690	674	674	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
KRR1	Q13601	220	277	2	381	Chain	ID=PRO_0000050114;Note=KRR1 small subunit processome component homolog
KRR1	Q13601	201	220	2	381	Chain	ID=PRO_0000050114;Note=KRR1 small subunit processome component homolog
KRR1	Q13601	173	201	2	381	Chain	ID=PRO_0000050114;Note=KRR1 small subunit processome component homolog
KRR1	Q13601	201	220	154	206	Domain	Note=KH
KRR1	Q13601	173	201	154	206	Domain	Note=KH
KRR1	Q13601	220	277	247	381	Compositional bias	Note=Lys-rich
KRR1	Q13601	220	277	221	277	Alternative sequence	ID=VSP_042223;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
KRR1	Q13601	201	220	206	206	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
KRR1	Q13601	220	277	275	275	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA2	Q15349	527	581	1	733	Chain	ID=PRO_0000086201;Note=Ribosomal protein S6 kinase alpha-2
RPS6KA2	Q15349	444	474	1	733	Chain	ID=PRO_0000086201;Note=Ribosomal protein S6 kinase alpha-2
RPS6KA2	Q15349	527	581	415	672	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA2	Q15349	444	474	415	672	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA2	Q15349	527	581	532	532	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPS6KA2	Q15349	444	474	444	444	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA2	Q15349	444	474	447	447	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KB1	P23443	104	127	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
RPS6KB1	P23443	290	326	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
RPS6KB1	P23443	326	347	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
RPS6KB1	P23443	104	127	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	290	326	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	326	347	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	104	127	97	105	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	104	127	123	123	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	104	127	104	126	Alternative sequence	ID=VSP_055026;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KB1	P23443	104	127	101	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	104	127	114	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	104	127	119	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	104	127	127	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	290	326	298	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	290	326	314	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A61
RPS6KB1	P23443	290	326	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	332	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	340	342	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	343	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
LEO1	Q8WVC0	271	306	2	666	Chain	ID=PRO_0000247819;Note=RNA polymerase-associated protein LEO1
LEO1	Q8WVC0	271	306	3	329	Compositional bias	Note=Asp-rich
LEO1	Q8WVC0	271	306	277	277	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
LEO1	Q8WVC0	271	306	279	279	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
LEO1	Q8WVC0	271	306	294	294	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:21406692,PMID:24275569
LEO1	Q8WVC0	271	306	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
LEO1	Q8WVC0	271	306	300	300	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569
LEPR	P48357	13	123	1	21	Signal peptide	.
LEPR	P48357	13	123	22	1165	Chain	ID=PRO_0000010904;Note=Leptin receptor
LEPR	P48357	13	123	22	839	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LEPR	P48357	13	123	23	23	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786864;Dbxref=PMID:9786864
LEPR	P48357	13	123	41	41	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786864;Dbxref=PMID:9786864
LEPR	P48357	13	123	56	56	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786864;Dbxref=PMID:9786864
LEPR	P48357	13	123	73	73	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786864;Dbxref=PMID:9786864
LEPR	P48357	13	123	81	81	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786864;Dbxref=PMID:9786864
LEPR	P48357	13	123	98	98	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786864;Dbxref=PMID:9786864
LEPR	P48357	13	123	37	90	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22405007;Dbxref=PMID:22405007
LEPR	P48357	13	123	89	99	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22405007;Dbxref=PMID:22405007
LEPR	P48357	13	123	109	109	Natural variant	ID=VAR_002703;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18987736,ECO:0000269|PubMed:8616721,ECO:0000269|PubMed:9144432,ECO:0000269|PubMed:9158141,ECO:0000269|PubMed:9175732,ECO:0000269|PubMed:9287054,ECO:0000269|PubMed:9860295;Dbxref=dbSNP:rs1137100,PMID:18987736,PMID:8616721,PMID:9144432,PMID:9158141,PMID:9175732,PMID:9287054,PMID:9860295
LEPR	P48357	13	123	85	85	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LEPR	P48357	13	123	85	85	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LEPR	P48357	13	123	85	85	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTG2	Q9H4K7	156	229	1	406	Chain	ID=PRO_0000205429;Note=Mitochondrial ribosome-associated GTPase 2
MTG2	Q9H4K7	156	229	225	390	Domain	Note=OBG-type G
MTG2	Q9H4K7	156	229	15	406	Region	Note=Localized in the mitochondria
MTG2	Q9H4K7	156	229	30	406	Region	Note=Not localized in the mitochondria
MTG2	Q9H4K7	156	229	1	228	Alternative sequence	ID=VSP_056672;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LGI3	Q8N145	117	140	31	548	Chain	ID=PRO_0000017710;Note=Leucine-rich repeat LGI family member 3
LGI3	Q8N145	117	140	113	134	Repeat	Note=LRR 2
LGI3	Q8N145	117	140	137	158	Repeat	Note=LRR 3
LGI3	Q8N145	117	140	117	140	Alternative sequence	ID=VSP_056297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LGMN	Q99538	273	340	18	323	Chain	ID=PRO_0000026502;Note=Legumain
LGMN	Q99538	160	181	18	323	Chain	ID=PRO_0000026502;Note=Legumain
LGMN	Q99538	273	340	18	323	Chain	ID=PRO_0000026502;Note=Legumain
LGMN	Q99538	160	181	18	323	Chain	ID=PRO_0000026502;Note=Legumain
LGMN	Q99538	340	397	324	433	Propeptide	ID=PRO_0000026503
LGMN	Q99538	273	340	324	433	Propeptide	ID=PRO_0000026503
LGMN	Q99538	340	397	324	433	Propeptide	ID=PRO_0000026503
LGMN	Q99538	273	340	324	433	Propeptide	ID=PRO_0000026503
LGMN	Q99538	273	340	323	324	Site	Note=Cleavage%3B by autolysis
LGMN	Q99538	273	340	323	324	Site	Note=Cleavage%3B by autolysis
LGMN	Q99538	160	181	167	167	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:23776206;Dbxref=PMID:19159218,PMID:23776206
LGMN	Q99538	160	181	167	167	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:23776206;Dbxref=PMID:19159218,PMID:23776206
LGMN	Q99538	340	397	378	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LGMN	Q99538	340	397	378	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LGMN	Q99538	340	397	390	429	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LGMN	Q99538	340	397	390	429	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LGMN	Q99538	340	397	341	397	Alternative sequence	ID=VSP_056454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGMN	Q99538	340	397	341	397	Alternative sequence	ID=VSP_056454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGMN	Q99538	340	397	341	372	Alternative sequence	ID=VSP_056455;Note=In isoform 3. ARHLIEKSVRKIVSLLAASEAEVEQLLSERAP->DKIVHGPRVPWSLLKSCLLEAFPSVSAPPTVC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGMN	Q99538	340	397	341	372	Alternative sequence	ID=VSP_056455;Note=In isoform 3. ARHLIEKSVRKIVSLLAASEAEVEQLLSERAP->DKIVHGPRVPWSLLKSCLLEAFPSVSAPPTVC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGMN	Q99538	340	397	373	433	Alternative sequence	ID=VSP_056456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGMN	Q99538	340	397	373	433	Alternative sequence	ID=VSP_056456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGMN	Q99538	273	340	323	323	Mutagenesis	Note=Loss of autoactivation. N->D%2CQ%2CS
LGMN	Q99538	273	340	323	323	Mutagenesis	Note=Loss of autoactivation. N->D%2CQ%2CS
LGMN	Q99538	160	181	157	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	160	181	157	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	160	181	163	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	160	181	163	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	160	181	180	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	160	181	180	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	273	340	273	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	273	340	273	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	273	340	281	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
LGMN	Q99538	273	340	281	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N6O
MTMR8	Q96EF0	8	49	1	704	Chain	ID=PRO_0000330034;Note=Myotubularin-related protein 8
MTMR10	Q9NXD2	516	577	1	777	Chain	ID=PRO_0000284360;Note=Myotubularin-related protein 10
MTMR10	Q9NXD2	516	577	221	661	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR10	Q9NXD2	516	577	219	777	Alternative sequence	ID=VSP_024466;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTMR10	Q9NXD2	516	577	517	533	Alternative sequence	ID=VSP_024467;Note=In isoform 2. EFAISKNIQLGDEKGLK->VSRIKSCTKQDYFPSRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTMR10	Q9NXD2	516	577	534	777	Alternative sequence	ID=VSP_024468;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LIMS1	P48059	215	246	2	325	Chain	ID=PRO_0000075888;Note=LIM and senescent cell antigen-like-containing domain protein 1
LIMS1	P48059	215	246	2	325	Chain	ID=PRO_0000075888;Note=LIM and senescent cell antigen-like-containing domain protein 1
LIMS1	P48059	215	246	193	243	Domain	Note=LIM zinc-binding 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
LIMS1	P48059	215	246	193	243	Domain	Note=LIM zinc-binding 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
LIMS1	P48059	215	246	214	216	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	214	216	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	220	222	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	220	222	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	227	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	227	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	232	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	232	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	237	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	237	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	241	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
LIMS1	P48059	215	246	241	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NYP
PPFIA1	Q13136	177	202	1	1202	Chain	ID=PRO_0000191026;Note=Liprin-alpha-1
PPFIA1	Q13136	476	497	1	1202	Chain	ID=PRO_0000191026;Note=Liprin-alpha-1
PPFIA1	Q13136	1105	1128	1	1202	Chain	ID=PRO_0000191026;Note=Liprin-alpha-1
PPFIA1	Q13136	1105	1128	1051	1120	Domain	Note=SAM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
PPFIA1	Q13136	177	202	176	214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIA1	Q13136	476	497	249	521	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIA1	Q13136	476	497	492	492	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIA1	Q13136	1105	1128	1121	1123	Sequence conflict	Note=GTD->PEF;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIBP1	Q86W92	119	157	1	1011	Chain	ID=PRO_0000191034;Note=Liprin-beta-1
PPFIBP1	Q86W92	157	201	1	1011	Chain	ID=PRO_0000191034;Note=Liprin-beta-1
PPFIBP1	Q86W92	232	263	1	1011	Chain	ID=PRO_0000191034;Note=Liprin-beta-1
PPFIBP1	Q86W92	477	487	1	1011	Chain	ID=PRO_0000191034;Note=Liprin-beta-1
PPFIBP1	Q86W92	755	796	1	1011	Chain	ID=PRO_0000191034;Note=Liprin-beta-1
PPFIBP1	Q86W92	755	796	719	782	Domain	Note=SAM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
PPFIBP1	Q86W92	119	157	156	405	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIBP1	Q86W92	157	201	156	405	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIBP1	Q86W92	232	263	156	405	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIBP1	Q86W92	755	796	794	794	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
PPFIBP1	Q86W92	119	157	1	153	Alternative sequence	ID=VSP_009394;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574462;Dbxref=PMID:10574462
PPFIBP1	Q86W92	157	201	158	170	Alternative sequence	ID=VSP_009395;Note=In isoform 5. ELLSRTSLETQKL->VCAEARTKMGFPC;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.4,ECO:0000303|Ref.5
PPFIBP1	Q86W92	157	201	171	1011	Alternative sequence	ID=VSP_009396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.4,ECO:0000303|Ref.5
PPFIBP1	Q86W92	232	263	171	1011	Alternative sequence	ID=VSP_009396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.4,ECO:0000303|Ref.5
PPFIBP1	Q86W92	477	487	171	1011	Alternative sequence	ID=VSP_009396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.4,ECO:0000303|Ref.5
PPFIBP1	Q86W92	755	796	171	1011	Alternative sequence	ID=VSP_009396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.4,ECO:0000303|Ref.5
PPFIBP1	Q86W92	232	263	233	263	Alternative sequence	ID=VSP_009397;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9624153;Dbxref=PMID:15489334,PMID:9624153
PPFIBP1	Q86W92	119	157	148	148	Natural variant	ID=VAR_017758;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10574462,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9624153,ECO:0000269|Ref.4,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2194816,PMID:10574462,PMID:15489334,PMID:9624153
LIPJ	Q5W064	192	241	1	366	Chain	ID=PRO_0000288970;Note=Lipase member J
LIPJ	Q5W064	192	241	210	210	Natural variant	ID=VAR_032543;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1409136,PMID:15489334
AATK	Q6ZMQ8	321	370	1	1374	Chain	ID=PRO_0000248300;Note=Serine/threonine-protein kinase LMTK1
AATK	Q6ZMQ8	321	370	125	395	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AATK	Q6ZMQ8	321	370	1	433	Alternative sequence	ID=VSP_020225;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LMTK2	Q8IWU2	333	382	1	1503	Chain	ID=PRO_0000259458;Note=Serine/threonine-protein kinase LMTK2
LMTK2	Q8IWU2	1413	1494	1	1503	Chain	ID=PRO_0000259458;Note=Serine/threonine-protein kinase LMTK2
LMTK2	Q8IWU2	333	382	64	1503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMTK2	Q8IWU2	1413	1494	64	1503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMTK2	Q8IWU2	333	382	137	407	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LMTK2	Q8IWU2	1413	1494	1451	1454	Compositional bias	Note=Poly-Pro
LMTK2	Q8IWU2	1413	1494	1450	1450	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LMTK2	Q8IWU2	1413	1494	1444	1454	Sequence conflict	Note=QTSKYFSPPPP->PSTLPAFPSHT;Ontology_term=ECO:0000305;evidence=ECO:0000305
LMTK2	Q8IWU2	1413	1494	1455	1503	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LONP2	Q86WA8	156	200	2	852	Chain	ID=PRO_0000287640;Note=Lon protease homolog 2%2C peroxisomal
LONP2	Q86WA8	156	200	13	220	Domain	Note=Lon N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01123
LONP2	Q86WA8	156	200	156	199	Alternative sequence	ID=VSP_056190;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCC2	Q92887	1329	1382	1	1545	Chain	ID=PRO_0000093356;Note=Canalicular multispecific organic anion transporter 1
ABCC2	Q92887	1438	1502	1	1545	Chain	ID=PRO_0000093356;Note=Canalicular multispecific organic anion transporter 1
ABCC2	Q92887	1329	1382	1256	1545	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC2	Q92887	1438	1502	1256	1545	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC2	Q92887	1329	1382	1300	1534	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC2	Q92887	1438	1502	1300	1534	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC2	Q92887	1329	1382	1334	1341	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC2	Q92887	1438	1502	1438	1438	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ABCC2	Q92887	1329	1382	1382	1382	Natural variant	ID=VAR_010756;Note=In DJS. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10053008;Dbxref=dbSNP:rs72558202,PMID:10053008
ABCC2	Q92887	1438	1502	1450	1450	Natural variant	ID=VAR_013330;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11266082;Dbxref=dbSNP:rs56296335,PMID:11266082
LAMA5	O15230	3120	3168	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	2985	3026	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	2732	2789	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	2216	2253	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	1766	1843	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	1738	1766	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	1646	1704	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	675	721	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	630	675	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	492	539	36	3695	Chain	ID=PRO_0000017062;Note=Laminin subunit alpha-5
LAMA5	O15230	492	539	494	540	Domain	Note=Laminin EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMA5	O15230	630	675	587	631	Domain	Note=Laminin EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMA5	O15230	675	721	632	676	Domain	Note=Laminin EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMA5	O15230	630	675	632	676	Domain	Note=Laminin EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMA5	O15230	675	721	677	722	Domain	Note=Laminin EGF-like 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMA5	O15230	1766	1843	1641	1830	Domain	Note=Laminin IV type A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00458
LAMA5	O15230	1738	1766	1641	1830	Domain	Note=Laminin IV type A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00458
LAMA5	O15230	1646	1704	1641	1830	Domain	Note=Laminin IV type A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00458
LAMA5	O15230	1766	1843	1831	1863	Domain	Note=Laminin EGF-like 16%3B second part;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMA5	O15230	2732	2789	2736	2929	Domain	Note=Laminin G-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
LAMA5	O15230	2985	3026	2941	3115	Domain	Note=Laminin G-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
LAMA5	O15230	3120	3168	3124	3292	Domain	Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
LAMA5	O15230	2732	2789	2167	2735	Region	Note=Domain II and I
LAMA5	O15230	2216	2253	2167	2735	Region	Note=Domain II and I
LAMA5	O15230	2216	2253	2203	2221	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMA5	O15230	1766	1843	1838	1840	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMA5	O15230	492	539	494	506	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	492	539	496	515	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	492	539	517	526	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	492	539	529	538	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	630	675	632	644	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	630	675	634	650	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	630	675	652	661	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	630	675	664	674	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	675	721	677	689	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	675	721	679	696	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	675	721	698	707	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	675	721	710	725	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA5	O15230	492	539	493	561	Alternative sequence	ID=VSP_057343;Note=In isoform 2. NCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCR->SGVSLCRPGWSAVARSRLTSTSASWVRAILLPQSPEWLGLQAPATTPGQFFVFLVETGFHHVGQAGLEL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	3120	3168	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	2985	3026	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	2732	2789	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	2216	2253	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	1766	1843	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	1738	1766	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	1646	1704	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	675	721	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	630	675	562	3695	Alternative sequence	ID=VSP_057344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA5	O15230	1646	1704	1667	1667	Natural variant	ID=VAR_030851;Note=R->W;Dbxref=dbSNP:rs13039398
LAMA5	O15230	1646	1704	1671	1671	Natural variant	ID=VAR_047888;Note=T->M;Dbxref=dbSNP:rs944893
LAMA5	O15230	1766	1843	1807	1807	Natural variant	ID=VAR_030853;Note=F->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11572484,ECO:0000269|PubMed:11821406;Dbxref=dbSNP:rs2427284,PMID:11572484,PMID:11821406
LAMA5	O15230	2216	2253	2226	2226	Natural variant	ID=VAR_030859;Note=R->H;Dbxref=dbSNP:rs2297587
LAMA5	O15230	2732	2789	2737	2742	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2732	2789	2744	2747	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2732	2789	2754	2756	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2732	2789	2759	2767	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2732	2789	2780	2786	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2985	3026	2987	2994	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2985	3026	2997	3006	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	2985	3026	3025	3032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	3120	3168	3117	3120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	3120	3168	3124	3136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	3120	3168	3147	3154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMA5	O15230	3120	3168	3158	3167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XAU
LAMB2	P55268	1641	1700	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	961	1036	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	781	829	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	345	408	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	153	216	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	1641	1700	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	961	1036	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	781	829	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	345	408	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	153	216	33	1798	Chain	ID=PRO_0000017068;Note=Laminin subunit beta-2
LAMB2	P55268	153	216	43	282	Domain	Note=Laminin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00466
LAMB2	P55268	153	216	43	282	Domain	Note=Laminin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00466
LAMB2	P55268	345	408	283	346	Domain	Note=Laminin EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	283	346	Domain	Note=Laminin EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	347	409	Domain	Note=Laminin EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	347	409	Domain	Note=Laminin EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	783	830	Domain	Note=Laminin EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	783	830	Domain	Note=Laminin EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	927	985	Domain	Note=Laminin EGF-like 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	927	985	Domain	Note=Laminin EGF-like 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	986	1037	Domain	Note=Laminin EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	986	1037	Domain	Note=Laminin EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	1641	1700	1443	1798	Region	Note=Domain I
LAMB2	P55268	1641	1700	1443	1798	Region	Note=Domain I
LAMB2	P55268	1641	1700	1577	1790	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB2	P55268	1641	1700	1577	1790	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB2	P55268	345	408	368	368	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB2	P55268	345	408	368	368	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB2	P55268	345	408	347	356	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	347	356	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	349	374	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	349	374	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	377	386	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	377	386	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	389	407	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	345	408	389	407	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	783	795	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	783	795	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	785	802	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	785	802	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	804	813	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	804	813	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	816	828	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	781	829	816	828	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	956	965	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	956	965	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	968	983	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	968	983	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	986	1000	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	986	1000	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	988	1007	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	988	1007	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	1010	1019	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	1010	1019	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	1022	1035	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	1022	1035	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB2	P55268	961	1036	987	987	Natural variant	ID=VAR_031971;Note=E->K;Dbxref=dbSNP:rs34759087
LAMB2	P55268	961	1036	987	987	Natural variant	ID=VAR_031971;Note=E->K;Dbxref=dbSNP:rs34759087
LAMP2	P13473	309	364	29	410	Chain	ID=PRO_0000017110;Note=Lysosome-associated membrane glycoprotein 2
LAMP2	P13473	247	288	29	410	Chain	ID=PRO_0000017110;Note=Lysosome-associated membrane glycoprotein 2
LAMP2	P13473	309	364	29	375	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP2	P13473	247	288	29	375	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP2	P13473	309	364	229	375	Region	Note=Second lumenal domain
LAMP2	P13473	247	288	229	375	Region	Note=Second lumenal domain
LAMP2	P13473	247	288	257	257	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
LAMP2	P13473	247	288	275	275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8323299;Dbxref=PMID:8323299
LAMP2	P13473	309	364	317	317	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8323299;Dbxref=PMID:8323299
LAMP2	P13473	309	364	356	356	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
LAMP2	P13473	247	288	232	265	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00740
LAMP2	P13473	309	364	331	368	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00740
LAMP2	P13473	247	288	256	256	Natural variant	ID=VAR_011992;Note=P->H;Dbxref=dbSNP:rs1043878
LAMP2	P13473	309	364	321	321	Natural variant	ID=VAR_026230;Note=In DAND. W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15673802,ECO:0000269|PubMed:15907287;Dbxref=dbSNP:rs104894859,PMID:15673802,PMID:15907287
LAMP2	P13473	247	288	263	269	Sequence conflict	Note=GSCRSHT->AAAVSH;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMP2	P13473	309	364	322	326	Sequence conflict	Note=DAPLG->MPP;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMP3	Q9UQV4	253	296	28	416	Chain	ID=PRO_0000223695;Note=Lysosome-associated membrane glycoprotein 3
LAMP3	Q9UQV4	253	296	28	381	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP3	Q9UQV4	253	296	266	266	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP3	Q9UQV4	253	296	291	291	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22809326;Dbxref=PMID:22809326
LAMP3	Q9UQV4	253	296	237	274	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00740,ECO:0000269|PubMed:22809326;Dbxref=PMID:22809326
LAMP3	Q9UQV4	253	296	251	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AKM
LAMP3	Q9UQV4	253	296	259	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AKM
LAMP3	Q9UQV4	253	296	265	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AKM
LAMP3	Q9UQV4	253	296	269	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AKM
LAMP3	Q9UQV4	253	296	276	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AKM
LAMP3	Q9UQV4	253	296	288	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AKM
LANCL2	Q9NS86	336	395	2	450	Chain	ID=PRO_0000191272;Note=LanC-like protein 2
LARP4	Q71RC2	55	107	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	250	268	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	268	339	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	374	444	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	461	515	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	250	268	203	281	Domain	Note=RRM
LARP4	Q71RC2	268	339	203	281	Domain	Note=RRM
LARP4	Q71RC2	250	268	111	303	Region	Note=Interaction with the poly-A tract of mRNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21098120;Dbxref=PMID:21098120
LARP4	Q71RC2	268	339	111	303	Region	Note=Interaction with the poly-A tract of mRNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21098120;Dbxref=PMID:21098120
LARP4	Q71RC2	374	444	392	392	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
LARP4	Q71RC2	461	515	505	505	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LARP4	Q71RC2	55	107	55	55	Alternative sequence	ID=VSP_033812;Note=In isoform 4. E->EVSVFNT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LARP4	Q71RC2	55	107	97	194	Alternative sequence	ID=VSP_014611;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LARP4	Q71RC2	268	339	269	339	Alternative sequence	ID=VSP_045677;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LARP4	Q71RC2	374	444	374	444	Alternative sequence	ID=VSP_046780;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LARP4	Q71RC2	461	515	446	724	Alternative sequence	ID=VSP_046781;Note=In isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LARP4	Q71RC2	461	515	502	502	Natural variant	ID=VAR_055937;Note=N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15498874;Dbxref=dbSNP:rs17124715,PMID:15498874
LARP4	Q71RC2	374	444	422	422	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LARP7	Q4G0J3	101	129	1	582	Chain	ID=PRO_0000281143;Note=La-related protein 7
LARP7	Q4G0J3	101	129	1	582	Chain	ID=PRO_0000281143;Note=La-related protein 7
LARP7	Q4G0J3	101	129	28	122	Domain	Note=HTH La-type RNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00332
LARP7	Q4G0J3	101	129	28	122	Domain	Note=HTH La-type RNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00332
LARP7	Q4G0J3	101	129	125	203	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
LARP7	Q4G0J3	101	129	125	203	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
LARP7	Q4G0J3	101	129	1	368	Alternative sequence	ID=VSP_024021;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
LARP7	Q4G0J3	101	129	1	368	Alternative sequence	ID=VSP_024021;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
LARP7	Q4G0J3	101	129	128	128	Mutagenesis	Note=Loss of 7SK RNA-binding and marked decrease in 7SK RNP complex formation. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18249148;Dbxref=PMID:18249148
LARP7	Q4G0J3	101	129	128	128	Mutagenesis	Note=Loss of 7SK RNA-binding and marked decrease in 7SK RNP complex formation. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18249148;Dbxref=PMID:18249148
LARP7	Q4G0J3	101	129	106	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WKR
LARP7	Q4G0J3	101	129	106	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WKR
LARP7	Q4G0J3	101	129	122	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WKR
LARP7	Q4G0J3	101	129	122	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WKR
LARP7	Q4G0J3	101	129	127	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WKR
LARP7	Q4G0J3	101	129	127	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WKR
MRS2	Q9HD23	369	407	50	443	Chain	ID=PRO_0000042837;Note=Magnesium transporter MRS2 homolog%2C mitochondrial
MRS2	Q9HD23	369	407	361	372	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRS2	Q9HD23	369	407	373	393	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRS2	Q9HD23	369	407	394	443	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRS2	Q9HD23	369	407	118	443	Alternative sequence	ID=VSP_016208;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAS1L	Q9Y4W2	347	364	1	734	Chain	ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L
LAS1L	Q9Y4W2	79	120	1	734	Chain	ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L
LAS1L	Q9Y4W2	79	120	79	120	Alternative sequence	ID=VSP_015178;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAS1L	Q9Y4W2	347	364	292	734	Alternative sequence	ID=VSP_015180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
LAS1L	Q9Y4W2	347	364	348	365	Alternative sequence	ID=VSP_015181;Note=In isoform 2 and isoform 3. DGQTEVQRGEGTDPKSHK->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC43A1	O75387	339	351	1	559	Chain	ID=PRO_0000218640;Note=Large neutral amino acids transporter small subunit 3
SLC43A1	O75387	155	186	1	559	Chain	ID=PRO_0000218640;Note=Large neutral amino acids transporter small subunit 3
SLC43A1	O75387	339	351	1	559	Chain	ID=PRO_0000218640;Note=Large neutral amino acids transporter small subunit 3
SLC43A1	O75387	155	186	1	559	Chain	ID=PRO_0000218640;Note=Large neutral amino acids transporter small subunit 3
SLC43A1	O75387	155	186	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC43A1	O75387	155	186	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LASP1	Q14847	83	119	1	261	Chain	ID=PRO_0000075761;Note=LIM and SH3 domain protein 1
LASP1	Q14847	83	119	1	261	Chain	ID=PRO_0000075761;Note=LIM and SH3 domain protein 1
LASP1	Q14847	83	119	61	95	Repeat	Note=Nebulin 1
LASP1	Q14847	83	119	61	95	Repeat	Note=Nebulin 1
LASP1	Q14847	83	119	97	131	Repeat	Note=Nebulin 2
LASP1	Q14847	83	119	97	131	Repeat	Note=Nebulin 2
LASP1	Q14847	83	119	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LASP1	Q14847	83	119	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LASP1	Q14847	83	119	104	104	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17924679,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
LASP1	Q14847	83	119	104	104	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17924679,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
LASP1	Q14847	83	119	112	112	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61792
LASP1	Q14847	83	119	112	112	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61792
LASP1	Q14847	83	119	118	118	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
LASP1	Q14847	83	119	118	118	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
LASP1	Q14847	83	119	1	83	Alternative sequence	ID=VSP_054611;Note=In isoform 3. MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQ->MLPLRDLQDDTEHEELQGLREEALLQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LASP1	Q14847	83	119	1	83	Alternative sequence	ID=VSP_054611;Note=In isoform 3. MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQ->MLPLRDLQDDTEHEELQGLREEALLQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LARP4B	Q92615	510	565	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	411	494	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	250	287	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	96	143	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	250	287	240	307	Domain	Note=RRM
LARP4B	Q92615	411	494	419	419	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
LARP4B	Q92615	411	494	424	424	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
LARP4B	Q92615	411	494	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648;Dbxref=PMID:16964243,PMID:18669648
LARP4B	Q92615	411	494	451	451	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
LARP4B	Q92615	411	494	488	488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LARP4B	Q92615	411	494	493	493	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6A0A2
LARP4B	Q92615	510	565	518	518	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
LARP4B	Q92615	510	565	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
LARP4B	Q92615	510	565	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LCA5L	O95447	279	325	1	670	Chain	ID=PRO_0000079507;Note=Lebercilin-like protein
LCA5L	O95447	279	325	1	670	Chain	ID=PRO_0000079507;Note=Lebercilin-like protein
LCA5L	O95447	279	325	1	670	Chain	ID=PRO_0000079507;Note=Lebercilin-like protein
LCA5L	O95447	279	325	305	336	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LCA5L	O95447	279	325	305	336	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LCA5L	O95447	279	325	305	336	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LCAT	P04180	174	249	25	440	Chain	ID=PRO_0000017802;Note=Phosphatidylcholine-sterol acyltransferase
LCAT	P04180	174	249	205	205	Active site	Note=Nucleophile;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26195816;Dbxref=PMID:26195816
LCAT	P04180	174	249	180	180	Natural variant	ID=VAR_004260;Note=In LCATD. Y->N;Dbxref=dbSNP:rs749740660
LCAT	P04180	174	249	182	182	Natural variant	ID=VAR_004261;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8318557,ECO:0000269|PubMed:8432868;Dbxref=dbSNP:rs387906300,PMID:8318557,PMID:8432868
LCAT	P04180	174	249	205	205	Natural variant	ID=VAR_039030;Note=In LCATD. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15994445;Dbxref=PMID:15994445
LCAT	P04180	174	249	232	232	Natural variant	ID=VAR_017030;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12957688,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:16874701;Dbxref=dbSNP:rs4986970,PMID:12957688,PMID:12966036,PMID:16874701
LCAT	P04180	174	249	233	233	Natural variant	ID=VAR_004262;Note=In LCATD. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8432868;Dbxref=dbSNP:rs28942087,PMID:8432868
LCAT	P04180	174	249	242	242	Natural variant	ID=VAR_039031;Note=In LCATD. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15994445;Dbxref=PMID:15994445
LCAT	P04180	174	249	246	246	Natural variant	ID=VAR_066864;Note=In a patient with low HDL-cholesterol levels%3B the mutant is hardly secreted and is catalytically inactive. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21901787;Dbxref=PMID:21901787
LCAT	P04180	174	249	174	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LCAT	P04180	174	249	178	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LCAT	P04180	174	249	199	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LCAT	P04180	174	249	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LCAT	P04180	174	249	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LCAT	P04180	174	249	227	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LCAT	P04180	174	249	242	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BV7
LDB2	O43679	177	205	1	373	Chain	ID=PRO_0000084387;Note=LIM domain-binding protein 2
LDB2	O43679	136	177	1	373	Chain	ID=PRO_0000084387;Note=LIM domain-binding protein 2
LGALS9B	Q3B8N2	180	192	1	356	Chain	ID=PRO_0000321949;Note=Galectin-9B
LGALS9B	Q3B8N2	180	192	185	185	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
LIMD1	Q9UGP4	469	503	1	676	Chain	ID=PRO_0000075801;Note=LIM domain-containing protein 1
LIMD1	Q9UGP4	608	631	1	676	Chain	ID=PRO_0000075801;Note=LIM domain-containing protein 1
LIMD1	Q9UGP4	469	503	470	531	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
LIMD1	Q9UGP4	608	631	595	664	Domain	Note=LIM zinc-binding 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
LIMD1	Q9UGP4	469	503	472	676	Region	Note=Necessary for nuclear localization
LIMD1	Q9UGP4	608	631	472	676	Region	Note=Necessary for nuclear localization
PPFIA3	O75145	194	219	1	1194	Chain	ID=PRO_0000191029;Note=Liprin-alpha-3
PPFIA3	O75145	1095	1118	1	1194	Chain	ID=PRO_0000191029;Note=Liprin-alpha-3
PPFIA3	O75145	1095	1118	1041	1110	Domain	Note=SAM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
PPFIA3	O75145	194	219	161	501	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIA3	O75145	194	219	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PPFIBP2	Q8ND30	124	162	1	876	Chain	ID=PRO_0000191036;Note=Liprin-beta-2
PPFIBP2	Q8ND30	398	412	1	876	Chain	ID=PRO_0000191036;Note=Liprin-beta-2
PPFIBP2	Q8ND30	506	548	1	876	Chain	ID=PRO_0000191036;Note=Liprin-beta-2
PPFIBP2	Q8ND30	707	749	1	876	Chain	ID=PRO_0000191036;Note=Liprin-beta-2
PPFIBP2	Q8ND30	749	812	1	876	Chain	ID=PRO_0000191036;Note=Liprin-beta-2
PPFIBP2	Q8ND30	707	749	718	783	Domain	Note=SAM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
PPFIBP2	Q8ND30	749	812	718	783	Domain	Note=SAM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
PPFIBP2	Q8ND30	124	162	101	313	Coiled coil	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21462929;Dbxref=PMID:21462929
PPFIBP2	Q8ND30	506	548	512	512	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPFIBP2	Q8ND30	124	162	1	143	Alternative sequence	ID=VSP_047382;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIBP2	Q8ND30	124	162	113	124	Alternative sequence	ID=VSP_047384;Note=In isoform 2. RLEGDKESLILQ->MSSEQWPRLPGK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPFIBP2	Q8ND30	124	162	144	162	Alternative sequence	ID=VSP_047385;Note=In isoform 3. VCLEGHQVKLNAAEEMLQQ->MGKLITRMWKLLRRRSAPK;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIBP2	Q8ND30	124	162	128	128	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIBP2	Q8ND30	124	162	161	161	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIBP2	Q8ND30	707	749	734	734	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPFIBP2	Q8ND30	749	812	754	754	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
LIPE	Q05469	712	788	1	1076	Chain	ID=PRO_0000071547;Note=Hormone-sensitive lipase
LIPE	Q05469	552	614	1	1076	Chain	ID=PRO_0000071547;Note=Hormone-sensitive lipase
LIPE	Q05469	712	788	725	725	Active site	Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q8BLF1,ECO:0000255|PROSITE-ProRule:PRU10038
LIPE	Q05469	552	614	608	608	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
L1CAM	P32004	1107	1152	20	1257	Chain	ID=PRO_0000015022;Note=Neural cell adhesion molecule L1
L1CAM	P32004	916	957	20	1257	Chain	ID=PRO_0000015022;Note=Neural cell adhesion molecule L1
L1CAM	P32004	609	646	20	1257	Chain	ID=PRO_0000015022;Note=Neural cell adhesion molecule L1
L1CAM	P32004	374	422	20	1257	Chain	ID=PRO_0000015022;Note=Neural cell adhesion molecule L1
L1CAM	P32004	1107	1152	20	1120	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
L1CAM	P32004	916	957	20	1120	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
L1CAM	P32004	609	646	20	1120	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
L1CAM	P32004	374	422	20	1120	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
L1CAM	P32004	1107	1152	1121	1143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
L1CAM	P32004	1107	1152	1144	1257	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
L1CAM	P32004	374	422	333	420	Domain	Note=Ig-like C2-type 4
L1CAM	P32004	609	646	615	712	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
L1CAM	P32004	916	957	814	916	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
L1CAM	P32004	916	957	920	1015	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
L1CAM	P32004	1107	1152	1016	1115	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
L1CAM	P32004	374	422	354	404	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
L1CAM	P32004	1107	1152	26	1257	Natural variant	ID=VAR_078350;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	26	1257	Natural variant	ID=VAR_078350;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	26	1257	Natural variant	ID=VAR_078350;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	26	1257	Natural variant	ID=VAR_078350;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	66	1257	Natural variant	ID=VAR_078353;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	66	1257	Natural variant	ID=VAR_078353;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	66	1257	Natural variant	ID=VAR_078353;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	66	1257	Natural variant	ID=VAR_078353;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	109	1257	Natural variant	ID=VAR_078354;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	109	1257	Natural variant	ID=VAR_078354;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	109	1257	Natural variant	ID=VAR_078354;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	109	1257	Natural variant	ID=VAR_078354;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	133	1257	Natural variant	ID=VAR_078356;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	133	1257	Natural variant	ID=VAR_078356;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	133	1257	Natural variant	ID=VAR_078356;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	133	1257	Natural variant	ID=VAR_078356;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	138	1257	Natural variant	ID=VAR_078357;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	138	1257	Natural variant	ID=VAR_078357;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	138	1257	Natural variant	ID=VAR_078357;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	138	1257	Natural variant	ID=VAR_078357;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	366	1257	Natural variant	ID=VAR_078364;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	366	1257	Natural variant	ID=VAR_078364;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	366	1257	Natural variant	ID=VAR_078364;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	366	1257	Natural variant	ID=VAR_078364;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	374	422	386	386	Natural variant	ID=VAR_003933;Note=In HSAS. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9744477;Dbxref=PMID:9744477
L1CAM	P32004	374	422	408	408	Natural variant	ID=VAR_030408;Note=In HSAS. N->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10797421;Dbxref=PMID:10797421
L1CAM	P32004	374	422	415	415	Natural variant	ID=VAR_027512;Note=In HSAS. A->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12435569,ECO:0000269|PubMed:19846429;Dbxref=PMID:12435569,PMID:19846429
L1CAM	P32004	374	422	421	421	Natural variant	ID=VAR_030409;Note=In HSAS. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10797421;Dbxref=PMID:10797421
L1CAM	P32004	1107	1152	423	1257	Natural variant	ID=VAR_078366;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	423	1257	Natural variant	ID=VAR_078366;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	423	1257	Natural variant	ID=VAR_078366;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	609	646	627	627	Natural variant	ID=VAR_078371;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=dbSNP:rs398123360,PMID:19846429
L1CAM	P32004	609	646	632	632	Natural variant	ID=VAR_003938;Note=In MASA. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452110;Dbxref=PMID:9452110
L1CAM	P32004	609	646	635	635	Natural variant	ID=VAR_078372;Note=Probable disease-associated mutation found in L1 syndrome%3B loss of localization at the cell surface%3B retention in the endoplasmic reticulum%3B loss of transport into axons%3B loss of neurite outgrowth%3B loss of cell-cell adhesion. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22222883;Dbxref=PMID:22222883
L1CAM	P32004	609	646	645	645	Natural variant	ID=VAR_078373;Note=Probable disease-associated mutation found in L1 syndrome%3B requires 2 nucleotide substitutions. I->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	662	1257	Natural variant	ID=VAR_078374;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	662	1257	Natural variant	ID=VAR_078374;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	760	1257	Natural variant	ID=VAR_078377;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	760	1257	Natural variant	ID=VAR_078377;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	789	1257	Natural variant	ID=VAR_078378;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19846429,ECO:0000269|PubMed:26891472;Dbxref=PMID:19846429,PMID:26891472
L1CAM	P32004	916	957	789	1257	Natural variant	ID=VAR_078378;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19846429,ECO:0000269|PubMed:26891472;Dbxref=PMID:19846429,PMID:26891472
L1CAM	P32004	1107	1152	811	1257	Natural variant	ID=VAR_078379;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	811	1257	Natural variant	ID=VAR_078379;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	891	1257	Natural variant	ID=VAR_078380;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	891	1257	Natural variant	ID=VAR_078380;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	901	1257	Natural variant	ID=VAR_078381;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	901	1257	Natural variant	ID=VAR_078381;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	916	957	935	935	Natural variant	ID=VAR_003943;Note=In HSAS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9521424;Dbxref=PMID:9521424
L1CAM	P32004	916	957	936	948	Natural variant	ID=VAR_003944;Note=In HSAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9195224;Dbxref=PMID:9195224
L1CAM	P32004	916	957	941	941	Natural variant	ID=VAR_003945;Note=In HSAS and MASA%3B decrease in neurite outgrowth%2C when assayed in NGF-treated pheochromocytoma PC12 cells%3B decrease in cell-matrix adhesion%3B decreased cell migration%3B no effect on the localization at the cell surface%3B no effect on cell proliferation%2C when transfected in pheochromocytoma PC12 cells. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22973895,ECO:0000269|PubMed:7762552;Dbxref=PMID:22973895,PMID:7762552
L1CAM	P32004	1107	1152	1064	1257	Natural variant	ID=VAR_078383;Note=Probable disease-associated mutation found in L1 syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19846429;Dbxref=PMID:19846429
L1CAM	P32004	1107	1152	1147	1153	Mutagenesis	Note=Loss of axon guidance%2C when assayed in a heterologous system%2C but normal synapse formation. KGGKYSV->AGGAASA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24155914;Dbxref=PMID:24155914
L1CAM	P32004	609	646	626	626	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
L1CAM	P32004	916	957	936	936	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
L1CAM	P32004	1107	1152	1116	1117	Sequence conflict	Note=GF->WLC;Ontology_term=ECO:0000305;evidence=ECO:0000305
KATNA1	O75449	243	296	1	491	Chain	ID=PRO_0000084594;Note=Katanin p60 ATPase-containing subunit A1
KATNA1	O75449	243	296	1	491	Chain	ID=PRO_0000084594;Note=Katanin p60 ATPase-containing subunit A1
KATNA1	O75449	243	296	249	256	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03023
KATNA1	O75449	243	296	249	256	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03023
KATNA1	O75449	243	296	168	243	Alternative sequence	ID=VSP_012948;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KATNA1	O75449	243	296	168	243	Alternative sequence	ID=VSP_012948;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KATNA1	O75449	243	296	255	255	Mutagenesis	Note=Abolishes ATP dependent microtubule severing activity and localization to spindle poles. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10751153,ECO:0000269|PubMed:11870226;Dbxref=PMID:10751153,PMID:11870226
KATNA1	O75449	243	296	255	255	Mutagenesis	Note=Abolishes ATP dependent microtubule severing activity and localization to spindle poles. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10751153,ECO:0000269|PubMed:11870226;Dbxref=PMID:10751153,PMID:11870226
LCMT1	Q9UIC8	230	264	1	334	Chain	ID=PRO_0000204422;Note=Leucine carboxyl methyltransferase 1
LCMT1	Q9UIC8	230	264	248	249	Sequence conflict	Note=RQ->PS;Ontology_term=ECO:0000305;evidence=ECO:0000305
LCMT1	Q9UIC8	230	264	251	251	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
LCMT1	Q9UIC8	230	264	221	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEI
LCMT1	Q9UIC8	230	264	236	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEI
LCMT1	Q9UIC8	230	264	247	249	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEI
LCMT1	Q9UIC8	230	264	255	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEI
LCMT1	Q9UIC8	230	264	261	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEI
LCTL	Q6UWM7	203	235	22	567	Chain	ID=PRO_0000042251;Note=Lactase-like protein
LCTL	Q6UWM7	203	235	23	541	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LCTL	Q6UWM7	203	235	212	212	Natural variant	ID=VAR_049297;Note=T->M;Dbxref=dbSNP:rs7179073
MRO	Q9BYG7	143	195	1	248	Chain	ID=PRO_0000248197;Note=Protein maestro
MRO	Q9BYG7	82	143	1	248	Chain	ID=PRO_0000248197;Note=Protein maestro
MRO	Q9BYG7	143	195	1	248	Chain	ID=PRO_0000248197;Note=Protein maestro
MRO	Q9BYG7	82	143	1	248	Chain	ID=PRO_0000248197;Note=Protein maestro
MRO	Q9BYG7	143	195	1	248	Chain	ID=PRO_0000248197;Note=Protein maestro
MRO	Q9BYG7	82	143	1	248	Chain	ID=PRO_0000248197;Note=Protein maestro
MRO	Q9BYG7	143	195	128	163	Repeat	Note=HEAT
MRO	Q9BYG7	82	143	128	163	Repeat	Note=HEAT
MRO	Q9BYG7	143	195	128	163	Repeat	Note=HEAT
MRO	Q9BYG7	82	143	128	163	Repeat	Note=HEAT
MRO	Q9BYG7	143	195	128	163	Repeat	Note=HEAT
MRO	Q9BYG7	82	143	128	163	Repeat	Note=HEAT
MRO	Q9BYG7	143	195	144	195	Alternative sequence	ID=VSP_045712;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MRO	Q9BYG7	143	195	144	195	Alternative sequence	ID=VSP_045712;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MRO	Q9BYG7	143	195	144	195	Alternative sequence	ID=VSP_045712;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MRO	Q9BYG7	82	143	134	134	Natural variant	ID=VAR_027262;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11401430,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2849233,PMID:11401430,PMID:14702039,PMID:15489334
MRO	Q9BYG7	82	143	134	134	Natural variant	ID=VAR_027262;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11401430,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2849233,PMID:11401430,PMID:14702039,PMID:15489334
MRO	Q9BYG7	82	143	134	134	Natural variant	ID=VAR_027262;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11401430,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2849233,PMID:11401430,PMID:14702039,PMID:15489334
MT1G	P13640	9	32	1	62	Chain	ID=PRO_0000197238;Note=Metallothionein-1G
MT1G	P13640	9	32	1	29	Region	Note=Beta
MT1G	P13640	9	32	31	62	Region	Note=Alpha
MT1G	P13640	9	32	14	14	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	16	16	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	20	20	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	22	22	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	25	25	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	27	27	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	30	30	Metal binding	Note=Divalent metal cation%3B cluster B
MT1G	P13640	9	32	10	10	Alternative sequence	ID=VSP_017230;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8119276;Dbxref=PMID:8119276
MTA1	Q13330	63	80	1	715	Chain	ID=PRO_0000083493;Note=Metastasis-associated protein MTA1
MTA1	Q13330	314	339	1	715	Chain	ID=PRO_0000083493;Note=Metastasis-associated protein MTA1
MTA1	Q13330	511	541	1	715	Chain	ID=PRO_0000083493;Note=Metastasis-associated protein MTA1
MTA1	Q13330	592	604	1	715	Chain	ID=PRO_0000083493;Note=Metastasis-associated protein MTA1
MTA1	Q13330	63	80	1	164	Domain	Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
MTA1	Q13330	314	339	283	335	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
MTA1	Q13330	511	541	522	522	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MTA1	Q13330	63	80	64	81	Alternative sequence	ID=VSP_042207;Note=In isoform 3. TLSVCYKAGPGADNGEEG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
MTA1	Q13330	511	541	431	715	Alternative sequence	ID=VSP_001602;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12167865;Dbxref=PMID:12167865
MTA1	Q13330	592	604	431	715	Alternative sequence	ID=VSP_001602;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12167865;Dbxref=PMID:12167865
MTA1	Q13330	314	339	320	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
MTA1	Q13330	511	541	505	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FXY
MTA1	Q13330	511	541	534	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FXY
TMBIM1	Q969X1	245	263	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	141	157	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	123	140	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	245	263	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	141	157	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	123	140	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	245	263	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	141	157	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	123	140	1	311	Chain	ID=PRO_0000179090;Note=Protein lifeguard 3
TMBIM1	Q969X1	123	140	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	123	140	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	123	140	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	141	157	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	123	140	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	141	157	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	123	140	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	141	157	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	123	140	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	245	263	246	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	245	263	246	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMBIM1	Q969X1	245	263	246	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTHFR	P42898	449	510	1	656	Chain	ID=PRO_0000190245;Note=Methylenetetrahydrofolate reductase
MTHFR	P42898	344	388	1	656	Chain	ID=PRO_0000190245;Note=Methylenetetrahydrofolate reductase
MTHFR	P42898	449	510	1	656	Chain	ID=PRO_0000190245;Note=Methylenetetrahydrofolate reductase
MTHFR	P42898	344	388	1	656	Chain	ID=PRO_0000190245;Note=Methylenetetrahydrofolate reductase
MTHFR	P42898	344	388	348	348	Natural variant	ID=VAR_074138;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204021,PMID:25736335
MTHFR	P42898	344	388	348	348	Natural variant	ID=VAR_074138;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204021,PMID:25736335
MTHFR	P42898	344	388	354	354	Natural variant	ID=VAR_074139;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204022,PMID:25736335
MTHFR	P42898	344	388	354	354	Natural variant	ID=VAR_074139;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204022,PMID:25736335
MTHFR	P42898	344	388	357	357	Natural variant	ID=VAR_004325;Note=In MTHFRD. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7726158;Dbxref=dbSNP:rs779993607,PMID:7726158
MTHFR	P42898	344	388	357	357	Natural variant	ID=VAR_004325;Note=In MTHFRD. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7726158;Dbxref=dbSNP:rs779993607,PMID:7726158
MTHFR	P42898	344	388	363	363	Natural variant	ID=VAR_074140;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204023,PMID:25736335
MTHFR	P42898	344	388	363	363	Natural variant	ID=VAR_074140;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204023,PMID:25736335
MTHFR	P42898	344	388	372	372	Natural variant	ID=VAR_074141;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204024,PMID:25736335
MTHFR	P42898	344	388	372	372	Natural variant	ID=VAR_074141;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204024,PMID:25736335
MTHFR	P42898	344	388	377	377	Natural variant	ID=VAR_009534;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25736335,ECO:0000269|PubMed:8940272;Dbxref=dbSNP:rs121434296,PMID:25736335,PMID:8940272
MTHFR	P42898	344	388	377	377	Natural variant	ID=VAR_009534;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25736335,ECO:0000269|PubMed:8940272;Dbxref=dbSNP:rs121434296,PMID:25736335,PMID:8940272
MTHFR	P42898	344	388	377	377	Natural variant	ID=VAR_074142;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs750323424,PMID:25736335
MTHFR	P42898	344	388	377	377	Natural variant	ID=VAR_074142;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs750323424,PMID:25736335
MTHFR	P42898	344	388	387	387	Natural variant	ID=VAR_009535;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679944,ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs1430872491,PMID:10679944,PMID:25736335
MTHFR	P42898	344	388	387	387	Natural variant	ID=VAR_009535;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679944,ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs1430872491,PMID:10679944,PMID:25736335
MTHFR	P42898	449	510	470	470	Natural variant	ID=VAR_054158;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18987736;Dbxref=PMID:18987736
MTHFR	P42898	449	510	470	470	Natural variant	ID=VAR_054158;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18987736;Dbxref=PMID:18987736
MTHFR	P42898	449	510	506	506	Natural variant	ID=VAR_074145;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204026,PMID:25736335
MTHFR	P42898	449	510	506	506	Natural variant	ID=VAR_074145;Note=In MTHFRD%3B reduced methylenetetrahydrofolate reductase activity%3B reduced affinity for NADPH. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25736335;Dbxref=dbSNP:rs786204026,PMID:25736335
MTHFR	P42898	344	388	346	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	346	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	355	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	355	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	365	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	365	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	371	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	344	388	371	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	462	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	462	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	468	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	468	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	480	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	480	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	488	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	488	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	496	498	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	496	498	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	506	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFR	P42898	449	510	506	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FCX
MTHFSD	Q2M296	41	79	1	383	Chain	ID=PRO_0000295871;Note=Methenyltetrahydrofolate synthase domain-containing protein
MTHFSD	Q2M296	41	79	43	79	Alternative sequence	ID=VSP_044492;Note=In isoform 3 and isoform 4. SYLACQNIKDLDVFARTQEVKVDPDKPLEGVRLLVLQ->ASHAAEQLPRLQAFKTARTIKVNPDAPQKSARFFVLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTHFSD	Q2M296	41	79	45	45	Natural variant	ID=VAR_033373;Note=L->V;Dbxref=dbSNP:rs34005514
MTHFSD	Q2M296	41	79	59	59	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
KXD1	Q9BQD3	34	84	1	176	Chain	ID=PRO_0000295259;Note=KxDL motif-containing protein 1
KXD1	Q9BQD3	34	84	1	176	Chain	ID=PRO_0000295259;Note=KxDL motif-containing protein 1
KXD1	Q9BQD3	34	84	1	176	Chain	ID=PRO_0000295259;Note=KxDL motif-containing protein 1
KXD1	Q9BQD3	34	84	1	176	Chain	ID=PRO_0000295259;Note=KxDL motif-containing protein 1
KXD1	Q9BQD3	34	84	1	176	Chain	ID=PRO_0000295259;Note=KxDL motif-containing protein 1
KXD1	Q9BQD3	34	84	1	176	Chain	ID=PRO_0000295259;Note=KxDL motif-containing protein 1
LANCL1	O43813	291	350	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	230	291	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	291	350	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	230	291	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	291	350	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	230	291	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	291	350	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	230	291	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	291	350	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	230	291	2	399	Chain	ID=PRO_0000191268;Note=LanC-like protein 1
LANCL1	O43813	230	291	276	276	Metal binding	Note=Zinc
LANCL1	O43813	230	291	276	276	Metal binding	Note=Zinc
LANCL1	O43813	230	291	276	276	Metal binding	Note=Zinc
LANCL1	O43813	230	291	276	276	Metal binding	Note=Zinc
LANCL1	O43813	230	291	276	276	Metal binding	Note=Zinc
LANCL1	O43813	291	350	322	322	Metal binding	Note=Zinc
LANCL1	O43813	291	350	322	322	Metal binding	Note=Zinc
LANCL1	O43813	291	350	322	322	Metal binding	Note=Zinc
LANCL1	O43813	291	350	322	322	Metal binding	Note=Zinc
LANCL1	O43813	291	350	322	322	Metal binding	Note=Zinc
LANCL1	O43813	291	350	323	323	Metal binding	Note=Zinc
LANCL1	O43813	291	350	323	323	Metal binding	Note=Zinc
LANCL1	O43813	291	350	323	323	Metal binding	Note=Zinc
LANCL1	O43813	291	350	323	323	Metal binding	Note=Zinc
LANCL1	O43813	291	350	323	323	Metal binding	Note=Zinc
LANCL1	O43813	291	350	317	317	Binding site	Note=Glutathione;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Binding site	Note=Glutathione;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Binding site	Note=Glutathione;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Binding site	Note=Glutathione;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Binding site	Note=Glutathione;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Mutagenesis	Note=Loss of glutathione binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Mutagenesis	Note=Loss of glutathione binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Mutagenesis	Note=Loss of glutathione binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Mutagenesis	Note=Loss of glutathione binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	317	317	Mutagenesis	Note=Loss of glutathione binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	322	322	Mutagenesis	Note=Loss of glutathione binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	322	322	Mutagenesis	Note=Loss of glutathione binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	322	322	Mutagenesis	Note=Loss of glutathione binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	322	322	Mutagenesis	Note=Loss of glutathione binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	291	350	322	322	Mutagenesis	Note=Loss of glutathione binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19528316;Dbxref=PMID:19528316
LANCL1	O43813	230	291	231	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	231	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	231	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	231	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	231	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	237	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	237	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	237	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	237	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	237	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	230	291	279	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	296	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	296	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	296	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	296	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	296	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E73
LANCL1	O43813	291	350	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E73
LANCL1	O43813	291	350	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E73
LANCL1	O43813	291	350	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E73
LANCL1	O43813	291	350	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E73
LANCL1	O43813	291	350	325	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	325	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	325	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	325	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	325	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	342	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	342	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	342	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	342	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
LANCL1	O43813	291	350	342	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6U
SLC7A5	Q01650	179	221	1	507	Chain	ID=PRO_0000054270;Note=Large neutral amino acids transporter small subunit 1
SLC7A5	Q01650	179	221	170	190	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A5	Q01650	179	221	199	219	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSB	P05455	223	270	1	408	Chain	ID=PRO_0000207599;Note=Lupus La protein
SSB	P05455	332	379	1	408	Chain	ID=PRO_0000207599;Note=Lupus La protein
SSB	P05455	223	270	1	408	Chain	ID=PRO_0000207599;Note=Lupus La protein
SSB	P05455	332	379	1	408	Chain	ID=PRO_0000207599;Note=Lupus La protein
SSB	P05455	223	270	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SSB	P05455	223	270	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SSB	P05455	332	379	341	341	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32067
SSB	P05455	332	379	341	341	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32067
SSB	P05455	332	379	360	360	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SSB	P05455	332	379	360	360	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SSB	P05455	332	379	362	362	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SSB	P05455	332	379	362	362	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SSB	P05455	332	379	366	366	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:9054510;Dbxref=PMID:17081983,PMID:18318008,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:9054510
SSB	P05455	332	379	366	366	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:9054510;Dbxref=PMID:17081983,PMID:18318008,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:9054510
SSB	P05455	223	270	233	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	233	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	246	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	246	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	259	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	259	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	269	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
SSB	P05455	223	270	269	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OWX
EVC2	Q86UK5	1186	1219	27	1308	Chain	ID=PRO_0000084363;Note=Limbin
EVC2	Q86UK5	290	335	27	1308	Chain	ID=PRO_0000084363;Note=Limbin
EVC2	Q86UK5	290	335	27	300	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC2	Q86UK5	290	335	301	321	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC2	Q86UK5	1186	1219	322	1308	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC2	Q86UK5	290	335	322	1308	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LBP	P18428	80	122	26	481	Chain	ID=PRO_0000017158;Note=Lipopolysaccharide-binding protein
LBP	P18428	123	174	26	481	Chain	ID=PRO_0000017158;Note=Lipopolysaccharide-binding protein
LBP	P18428	307	327	26	481	Chain	ID=PRO_0000017158;Note=Lipopolysaccharide-binding protein
LBP	P18428	123	174	159	198	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61805
LBP	P18428	80	122	111	111	Natural variant	ID=VAR_049737;Note=R->Q;Dbxref=dbSNP:rs2232583
LBP	P18428	123	174	125	125	Natural variant	ID=VAR_028244;Note=L->I;Dbxref=dbSNP:rs2232585
LBP	P18428	123	174	147	147	Natural variant	ID=VAR_049738;Note=E->K;Dbxref=dbSNP:rs36015492
LBP	P18428	123	174	157	157	Natural variant	ID=VAR_061293;Note=S->C;Dbxref=dbSNP:rs2232586
LBP	P18428	123	174	166	166	Natural variant	ID=VAR_028245;Note=V->M;Dbxref=dbSNP:rs5744204
LBP	P18428	80	122	82	82	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
LBP	P18428	123	174	128	128	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
LBP	P18428	123	174	154	157	Sequence conflict	Note=VTAS->GYCL;Ontology_term=ECO:0000305;evidence=ECO:0000305
LBP	P18428	123	174	174	174	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MSL1	Q68DK7	458	474	1	614	Chain	ID=PRO_0000349236;Note=Male-specific lethal 1 homolog
MSRB3	Q8IXL7	69	94	33	192	Chain	ID=PRO_0000327240;Note=Methionine-R-sulfoxide reductase B3
MSRB3	Q8IXL7	69	94	47	169	Domain	Note=MsrB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01126
MSRB3	Q8IXL7	69	94	86	86	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01126
MSRB3	Q8IXL7	69	94	89	89	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01126
MSRB3	Q8IXL7	69	94	89	89	Natural variant	ID=VAR_064904;Note=In DFNB74%3B abolishes zinc-binding and enzymatic activity. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21185009;Dbxref=dbSNP:rs387907088,PMID:21185009
LETM1	O95202	492	536	116	739	Chain	ID=PRO_0000017694;Note=Mitochondrial proton/calcium exchanger protein
LETM1	O95202	360	400	116	739	Chain	ID=PRO_0000017694;Note=Mitochondrial proton/calcium exchanger protein
LETM1	O95202	292	360	116	739	Chain	ID=PRO_0000017694;Note=Mitochondrial proton/calcium exchanger protein
LETM1	O95202	246	292	116	739	Chain	ID=PRO_0000017694;Note=Mitochondrial proton/calcium exchanger protein
LETM1	O95202	492	536	230	739	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2I0
LETM1	O95202	360	400	230	739	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2I0
LETM1	O95202	292	360	230	739	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2I0
LETM1	O95202	246	292	230	739	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2I0
LETM1	O95202	492	536	252	537	Domain	Note=Letm1 RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01094
LETM1	O95202	360	400	252	537	Domain	Note=Letm1 RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01094
LETM1	O95202	292	360	252	537	Domain	Note=Letm1 RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01094
LETM1	O95202	246	292	252	537	Domain	Note=Letm1 RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01094
LETM1	O95202	292	360	292	294	Alternative sequence	ID=VSP_037815;Note=In isoform 2 and isoform 3. KIR->QVL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
LETM1	O95202	246	292	292	294	Alternative sequence	ID=VSP_037815;Note=In isoform 2 and isoform 3. KIR->QVL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
LETM1	O95202	492	536	295	739	Alternative sequence	ID=VSP_037816;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
LETM1	O95202	360	400	295	739	Alternative sequence	ID=VSP_037816;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
LETM1	O95202	292	360	295	739	Alternative sequence	ID=VSP_037816;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
MTF2	Q9Y483	330	386	1	593	Chain	ID=PRO_0000059317;Note=Metal-response element-binding transcription factor 2
MTF2	Q9Y483	330	386	360	360	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MTF2	Q9Y483	330	386	1	331	Alternative sequence	ID=VSP_004696;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MTF2	Q9Y483	330	386	331	387	Alternative sequence	ID=VSP_053348;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTF2	Q9Y483	330	386	328	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFR
MTF2	Q9Y483	330	386	331	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFR
MTF2	Q9Y483	330	386	334	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFR
MTF2	Q9Y483	330	386	343	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFR
LGR6	Q9HBX8	52	75	25	967	Chain	ID=PRO_0000069699;Note=Leucine-rich repeat-containing G-protein coupled receptor 6
LGR6	Q9HBX8	147	170	25	967	Chain	ID=PRO_0000069699;Note=Leucine-rich repeat-containing G-protein coupled receptor 6
LGR6	Q9HBX8	240	263	25	967	Chain	ID=PRO_0000069699;Note=Leucine-rich repeat-containing G-protein coupled receptor 6
LGR6	Q9HBX8	264	287	25	967	Chain	ID=PRO_0000069699;Note=Leucine-rich repeat-containing G-protein coupled receptor 6
LGR6	Q9HBX8	288	329	25	967	Chain	ID=PRO_0000069699;Note=Leucine-rich repeat-containing G-protein coupled receptor 6
LGR6	Q9HBX8	52	75	25	567	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR6	Q9HBX8	147	170	25	567	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR6	Q9HBX8	240	263	25	567	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR6	Q9HBX8	264	287	25	567	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR6	Q9HBX8	288	329	25	567	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR6	Q9HBX8	52	75	26	66	Domain	Note=LRRNT
LGR6	Q9HBX8	147	170	139	160	Repeat	Note=LRR 3
LGR6	Q9HBX8	147	170	163	186	Repeat	Note=LRR 4
LGR6	Q9HBX8	240	263	235	256	Repeat	Note=LRR 7
LGR6	Q9HBX8	240	263	258	279	Repeat	Note=LRR 8
LGR6	Q9HBX8	264	287	258	279	Repeat	Note=LRR 8
LGR6	Q9HBX8	264	287	282	303	Repeat	Note=LRR 9
LGR6	Q9HBX8	288	329	282	303	Repeat	Note=LRR 9
LGR6	Q9HBX8	288	329	306	328	Repeat	Note=LRR 10
LGR6	Q9HBX8	288	329	329	350	Repeat	Note=LRR 11
LGR6	Q9HBX8	52	75	1	71	Alternative sequence	ID=VSP_028006;Note=In isoform 1. MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYL->MRLEGEGRSARAGQNLSRAGSARRGAPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10935549;Dbxref=PMID:10935549
LGR6	Q9HBX8	52	75	1	71	Alternative sequence	ID=VSP_013596;Note=In isoform 2. MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYL->MGRPRLTLVCQVSIIISAR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
LGR6	Q9HBX8	147	170	144	239	Alternative sequence	ID=VSP_028007;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10935549;Dbxref=PMID:10935549
LGR6	Q9HBX8	264	287	267	267	Natural variant	ID=VAR_049413;Note=N->K;Dbxref=dbSNP:rs7553800
LHFPL4	Q7Z7J7	135	214	1	247	Chain	ID=PRO_0000285961;Note=LHFPL tetraspan subfamily member 4 protein
LHFPL4	Q7Z7J7	135	214	127	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LHFPL4	Q7Z7J7	135	214	178	198	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLO1	Q04760	125	155	2	184	Chain	ID=PRO_0000168076;Note=Lactoylglutathione lyase
GLO1	Q04760	125	155	31	177	Domain	Note=VOC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01163
GLO1	Q04760	125	155	127	127	Metal binding	Note=Zinc%3B via tele nitrogen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23122816,ECO:0000269|PubMed:9218781,ECO:0000269|PubMed:9705294;Dbxref=PMID:23122816,PMID:9218781,PMID:9705294
GLO1	Q04760	125	155	127	127	Binding site	Note=Substrate
GLO1	Q04760	125	155	139	139	Modified residue	Note=S-glutathionyl cysteine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20454679;Dbxref=PMID:20454679
GLO1	Q04760	125	155	148	148	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GLO1	Q04760	125	155	148	148	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CPU0
GLO1	Q04760	125	155	61	139	Disulfide bond	Note=Alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20454679;Dbxref=PMID:20454679
GLO1	Q04760	125	155	139	139	Mutagenesis	Note=Impaired NO-mediated modification. Loss of NO-mediated modification%3B when associated with A-19 or A-20. C->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17576200,ECO:0000269|PubMed:19199007;Dbxref=PMID:17576200,PMID:19199007
GLO1	Q04760	125	155	124	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3W0T
GLO1	Q04760	125	155	135	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3W0T
GLO1	Q04760	125	155	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3W0T
GLO1	Q04760	125	155	155	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3W0T
LHX8	Q68G74	238	270	1	356	Chain	ID=PRO_0000295810;Note=LIM/homeobox protein Lhx8
LHX8	Q68G74	238	270	225	284	DNA binding	Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
LIMD2	Q9BT23	14	28	1	127	Chain	ID=PRO_0000251207;Note=LIM domain-containing protein 2
LIMD2	Q9BT23	14	28	1	127	Chain	ID=PRO_0000251207;Note=LIM domain-containing protein 2
LIMD2	Q9BT23	14	28	1	127	Chain	ID=PRO_0000251207;Note=LIM domain-containing protein 2
LIN7B	Q9HAP6	52	76	1	207	Chain	ID=PRO_0000189626;Note=Protein lin-7 homolog B
LIN7B	Q9HAP6	76	146	1	207	Chain	ID=PRO_0000189626;Note=Protein lin-7 homolog B
LIN7B	Q9HAP6	52	76	10	65	Domain	Note=L27;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
LIN7B	Q9HAP6	76	146	93	175	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
LIN7B	Q9HAP6	76	146	77	146	Alternative sequence	ID=VSP_042156;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIN7B	Q9HAP6	52	76	65	65	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LIN7B	Q9HAP6	76	146	93	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKR
LIN7B	Q9HAP6	76	146	105	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKR
LIN7B	Q9HAP6	76	146	110	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKR
LIN7B	Q9HAP6	76	146	118	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKR
LIN7B	Q9HAP6	76	146	127	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKR
LIN7B	Q9HAP6	76	146	139	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKR
KLHL12	Q53G59	431	464	1	568	Chain	ID=PRO_0000234349;Note=Kelch-like protein 12
KLHL12	Q53G59	189	239	1	568	Chain	ID=PRO_0000234349;Note=Kelch-like protein 12
KLHL12	Q53G59	189	239	135	236	Domain	Note=BACK
KLHL12	Q53G59	431	464	427	473	Repeat	Note=Kelch 4
KLHL12	Q53G59	431	464	405	568	Region	Note=Interaction with DVL3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16547521;Dbxref=PMID:16547521
KLHL12	Q53G59	189	239	197	198	Sequence conflict	Note=FE->LG;Ontology_term=ECO:0000305;evidence=ECO:0000305
KLHL12	Q53G59	431	464	427	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VPJ
KLHL12	Q53G59	431	464	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VPJ
KLHL12	Q53G59	431	464	448	450	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VPJ
KLHL12	Q53G59	431	464	453	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VPJ
KLHL32	Q96NJ5	68	104	1	620	Chain	ID=PRO_0000119083;Note=Kelch-like protein 32
KLHL32	Q96NJ5	104	137	1	620	Chain	ID=PRO_0000119083;Note=Kelch-like protein 32
KLHL32	Q96NJ5	137	209	1	620	Chain	ID=PRO_0000119083;Note=Kelch-like protein 32
KLHL32	Q96NJ5	68	104	42	109	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
KLHL32	Q96NJ5	104	137	42	109	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
KLHL32	Q96NJ5	68	104	69	104	Alternative sequence	ID=VSP_054888;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLHL32	Q96NJ5	104	137	69	104	Alternative sequence	ID=VSP_054888;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLHL32	Q96NJ5	104	137	105	137	Alternative sequence	ID=VSP_054889;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLHL32	Q96NJ5	137	209	105	137	Alternative sequence	ID=VSP_054889;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLHL32	Q96NJ5	104	137	129	129	Natural variant	ID=VAR_028279;Note=N->S;Dbxref=dbSNP:rs2294763
KLHL32	Q96NJ5	137	209	146	146	Natural variant	ID=VAR_028280;Note=D->G;Dbxref=dbSNP:rs12662753
KLHL4	Q9C0H6	308	379	1	718	Chain	ID=PRO_0000119104;Note=Kelch-like protein 4
MOV10	Q9HCE1	46	113	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	279	323	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	540	593	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	836	861	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	46	113	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	279	323	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	540	593	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	836	861	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	46	113	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	279	323	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	540	593	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	836	861	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MOV10	Q9HCE1	432	490	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MOV10	Q9HCE1	432	490	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MOV10	Q9HCE1	46	113	47	56	Alternative sequence	ID=VSP_037305;Note=In isoform 3. FGTPAPGFSS->LASSKSILQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	47	56	Alternative sequence	ID=VSP_037305;Note=In isoform 3. FGTPAPGFSS->LASSKSILQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	47	56	Alternative sequence	ID=VSP_037305;Note=In isoform 3. FGTPAPGFSS->LASSKSILQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	279	323	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	432	490	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	540	593	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	279	323	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	432	490	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	540	593	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	279	323	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	432	490	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	540	593	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	838	900	Alternative sequence	ID=VSP_010943;Note=In isoform 2. EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK->RSSVTSKGGAPPPDGTSLISRPLGRGSRSLGLCWLRISEEHQGQLPPPFVPQLPGLLPGSLLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MOV10	Q9HCE1	836	861	838	900	Alternative sequence	ID=VSP_010943;Note=In isoform 2. EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK->RSSVTSKGGAPPPDGTSLISRPLGRGSRSLGLCWLRISEEHQGQLPPPFVPQLPGLLPGSLLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MOV10	Q9HCE1	836	861	838	900	Alternative sequence	ID=VSP_010943;Note=In isoform 2. EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK->RSSVTSKGGAPPPDGTSLISRPLGRGSRSLGLCWLRISEEHQGQLPPPFVPQLPGLLPGSLLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MOV10	Q9HCE1	46	113	98	98	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MOV10	Q9HCE1	46	113	98	98	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MOV10	Q9HCE1	46	113	98	98	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA4	O75676	18	42	1	772	Chain	ID=PRO_0000086205;Note=Ribosomal protein S6 kinase alpha-4
RPS6KA4	O75676	42	115	1	772	Chain	ID=PRO_0000086205;Note=Ribosomal protein S6 kinase alpha-4
RPS6KA4	O75676	302	357	1	772	Chain	ID=PRO_0000086205;Note=Ribosomal protein S6 kinase alpha-4
RPS6KA4	O75676	18	42	33	301	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA4	O75676	42	115	33	301	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA4	O75676	302	357	302	371	Domain	Note=AGC-kinase C-terminal
RPS6KA4	O75676	18	42	39	47	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA4	O75676	42	115	39	47	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA4	O75676	42	115	65	65	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA4	O75676	302	357	343	343	Modified residue	Note=Phosphoserine%3B by MAPK1%2C MAPK3 and MAPK14;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA4	O75676	302	357	347	347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:19369195,PMID:23186163
KATNBL1	Q9H079	233	262	1	304	Chain	ID=PRO_0000089981;Note=KATNB1-like protein 1
KATNBL1	Q9H079	186	202	1	304	Chain	ID=PRO_0000089981;Note=KATNB1-like protein 1
KRTDAP	P60985	71	87	23	99	Chain	ID=PRO_0000022609;Note=Keratinocyte differentiation-associated protein
KRTDAP	P60985	42	56	23	99	Chain	ID=PRO_0000022609;Note=Keratinocyte differentiation-associated protein
KRTDAP	P60985	42	56	45	58	Alternative sequence	ID=VSP_030856;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15140226;Dbxref=PMID:15140226
RPS6KB2	Q9UBS0	302	323	1	482	Chain	ID=PRO_0000086214;Note=Ribosomal protein S6 kinase beta-2
RPS6KB2	Q9UBS0	302	323	67	328	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB2	Q9UBS0	302	323	155	482	Alternative sequence	ID=VSP_056442;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LEF1	Q9UJU2	336	372	1	399	Chain	ID=PRO_0000048595;Note=Lymphoid enhancer-binding factor 1
LEF1	Q9UJU2	213	240	1	399	Chain	ID=PRO_0000048595;Note=Lymphoid enhancer-binding factor 1
LEF1	Q9UJU2	336	372	299	367	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
LEF1	Q9UJU2	213	240	77	273	Compositional bias	Note=Pro-rich
LEF1	Q9UJU2	213	240	214	241	Alternative sequence	ID=VSP_040068;Note=In isoform 5%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:19653274;Dbxref=PMID:14702039,PMID:15489334,PMID:19653274
LEF1	Q9UJU2	336	372	283	399	Alternative sequence	ID=VSP_002188;Note=In isoform 2 and isoform 4. KPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI->CSAFLLPHPFLIPSTPSPNHHHHHLLGSLSMNRERSRSQKDLTLRSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GRINA	Q7Z429	164	231	1	371	Chain	ID=PRO_0000314439;Note=Protein lifeguard 1
GRINA	Q7Z429	231	274	1	371	Chain	ID=PRO_0000314439;Note=Protein lifeguard 1
GRINA	Q7Z429	164	231	1	371	Chain	ID=PRO_0000314439;Note=Protein lifeguard 1
GRINA	Q7Z429	231	274	1	371	Chain	ID=PRO_0000314439;Note=Protein lifeguard 1
GRINA	Q7Z429	164	231	165	185	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	164	231	165	185	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	164	231	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	164	231	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	164	231	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	231	274	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	164	231	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	231	274	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	231	274	253	273	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	231	274	253	273	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRINA	Q7Z429	164	231	224	224	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GRINA	Q7Z429	164	231	224	224	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LEFTY2	O00292	166	245	77	366	Chain	ID=PRO_0000033807;Note=Left-right determination factor 2
LEFTY2	O00292	166	245	183	183	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	1	18	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8390986,ECO:0000269|PubMed:8454062,ECO:0000269|PubMed:8757764;Dbxref=PMID:8390986,PMID:8454062,PMID:8757764
LGALS3BP	Q08380	81	125	19	585	Chain	ID=PRO_0000033230;Note=Galectin-3-binding protein
LGALS3BP	Q08380	17	81	19	585	Chain	ID=PRO_0000033230;Note=Galectin-3-binding protein
LGALS3BP	Q08380	81	125	24	124	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LGALS3BP	Q08380	17	81	24	124	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
LGALS3BP	Q08380	17	81	69	69	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:9501082;Dbxref=PMID:15084671,PMID:16335952,PMID:16740002,PMID:18780401,PMID:19139490,PMID:19159218,PMID:9501082
LGALS3BP	Q08380	81	125	125	125	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
LGALS3BP	Q08380	81	125	49	113	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1BY2,ECO:0000269|PubMed:9501082;Dbxref=PMID:9501082
LGALS3BP	Q08380	17	81	49	113	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1BY2,ECO:0000269|PubMed:9501082;Dbxref=PMID:9501082
LGALS3BP	Q08380	81	125	62	123	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1BY2,ECO:0000269|PubMed:9501082;Dbxref=PMID:9501082
LGALS3BP	Q08380	17	81	62	123	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1BY2,ECO:0000269|PubMed:9501082;Dbxref=PMID:9501082
LGALS3BP	Q08380	81	125	93	103	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1BY2,ECO:0000269|PubMed:9501082;Dbxref=PMID:9501082
LGALS3BP	Q08380	17	81	19	19	Sequence conflict	Note=V->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	25	25	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	25	25	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	26	26	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	30	31	Sequence conflict	Note=GA->ED;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	36	36	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	36	36	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGALS3BP	Q08380	17	81	24	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	17	81	34	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	17	81	44	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	17	81	55	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	17	81	70	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	17	81	76	79	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	81	125	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	81	125	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	81	125	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGALS3BP	Q08380	81	125	120	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY2
LGI1	O95970	72	95	35	557	Chain	ID=PRO_0000017705;Note=Leucine-rich glioma-inactivated protein 1
LGI1	O95970	72	95	35	72	Domain	Note=LRRNT
LGI1	O95970	72	95	92	113	Repeat	Note=LRR 1
LGI1	O95970	72	95	70	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y30
LGI1	O95970	72	95	84	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y30
LGI1	O95970	72	95	94	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y30
LGR4	Q9BXB1	301	323	25	951	Chain	ID=PRO_0000012792;Note=Leucine-rich repeat-containing G-protein coupled receptor 4
LGR4	Q9BXB1	86	109	25	951	Chain	ID=PRO_0000012792;Note=Leucine-rich repeat-containing G-protein coupled receptor 4
LGR4	Q9BXB1	301	323	25	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR4	Q9BXB1	86	109	25	544	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR4	Q9BXB1	86	109	82	103	Repeat	Note=LRR 2
LGR4	Q9BXB1	86	109	106	127	Repeat	Note=LRR 3
LGR4	Q9BXB1	301	323	320	341	Repeat	Note=LRR 11
LGR4	Q9BXB1	301	323	314	314	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR4	Q9BXB1	86	109	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXE
LGR4	Q9BXB1	86	109	98	103	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXE
LGR4	Q9BXB1	86	109	109	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXE
LGR4	Q9BXB1	301	323	300	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXE
LGR4	Q9BXB1	301	323	323	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXE
LGR5	O75473	95	118	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	143	214	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	215	238	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	239	261	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	262	285	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	379	402	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	517	545	22	907	Chain	ID=PRO_0000012794;Note=Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5	O75473	95	118	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	143	214	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	215	238	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	239	261	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	262	285	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	379	402	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	517	545	22	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LGR5	O75473	95	118	91	112	Repeat	Note=LRR 2
LGR5	O75473	95	118	115	136	Repeat	Note=LRR 3
LGR5	O75473	143	214	139	160	Repeat	Note=LRR 4
LGR5	O75473	143	214	163	184	Repeat	Note=LRR 5
LGR5	O75473	143	214	187	208	Repeat	Note=LRR 6
LGR5	O75473	143	214	211	232	Repeat	Note=LRR 7
LGR5	O75473	215	238	211	232	Repeat	Note=LRR 7
LGR5	O75473	215	238	235	256	Repeat	Note=LRR 8
LGR5	O75473	239	261	235	256	Repeat	Note=LRR 8
LGR5	O75473	239	261	258	279	Repeat	Note=LRR 9
LGR5	O75473	262	285	258	279	Repeat	Note=LRR 9
LGR5	O75473	262	285	282	303	Repeat	Note=LRR 10
LGR5	O75473	379	402	375	396	Repeat	Note=LRR 14
LGR5	O75473	379	402	399	420	Repeat	Note=LRR 15
LGR5	O75473	143	214	208	208	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23756651;Dbxref=PMID:23756651
LGR5	O75473	517	545	479	541	Disulfide bond	.
LGR5	O75473	143	214	143	214	Alternative sequence	ID=VSP_054782;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
LGR5	O75473	262	285	263	286	Alternative sequence	ID=VSP_037746;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LGR5	O75473	379	402	383	383	Natural variant	ID=VAR_049411;Note=H->R;Dbxref=dbSNP:rs12303775
LGR5	O75473	143	214	146	146	Mutagenesis	Note=Abolishes activation of Wnt signaling. D->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23809763;Dbxref=PMID:23809763
LGR5	O75473	143	214	170	170	Mutagenesis	Note=Abolishes activation of Wnt signaling. D->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23809763;Dbxref=PMID:23809763
LGR5	O75473	143	214	190	190	Mutagenesis	Note=Abolishes activation of Wnt signaling. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23809763;Dbxref=PMID:23809763
LGR5	O75473	143	214	212	212	Sequence conflict	Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
LGR5	O75473	95	118	94	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
LGR5	O75473	95	118	107	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
LGR5	O75473	95	118	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
LGR5	O75473	143	214	141	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	143	214	158	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	143	214	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	143	214	179	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	143	214	190	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	143	214	205	208	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	143	214	214	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	215	238	214	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	215	238	227	232	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	215	238	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	239	261	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	239	261	252	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	239	261	261	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	262	285	261	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	262	285	274	279	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	262	285	285	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	379	402	380	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	379	402	393	396	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
LGR5	O75473	379	402	401	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	517	545	522	524	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	517	545	535	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LGR5	O75473	517	545	538	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UFR
LLGL2	Q6P1M3	725	764	1	1020	Chain	ID=PRO_0000232728;Note=Lethal(2) giant larvae protein homolog 2
LLGL2	Q6P1M3	725	764	713	769	Repeat	Note=WD 11
LLGL2	Q6P1M3	725	764	357	1020	Alternative sequence	ID=VSP_047388;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LLGL2	Q6P1M3	725	764	748	748	Natural variant	ID=VAR_034058;Note=R->H;Dbxref=dbSNP:rs35474687
LLGL2	Q6P1M3	725	764	759	759	Natural variant	ID=VAR_050073;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1661715,PMID:15489334
ABCC4	O15439	1245	1290	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	1122	1152	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	1070	1122	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	678	725	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	421	451	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	387	421	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	262	303	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	177	207	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	102	177	1	1325	Chain	ID=PRO_0000093362;Note=Multidrug resistance-associated protein 4
ABCC4	O15439	102	177	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	102	177	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	177	207	207	227	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	421	451	440	460	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	678	725	710	730	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	262	303	92	377	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	177	207	92	377	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	102	177	92	377	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	421	451	410	633	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	387	421	410	633	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	678	725	714	1005	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC4	O15439	1245	1290	1041	1274	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	1122	1152	1041	1274	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	1070	1122	1041	1274	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	421	451	445	452	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	1070	1122	1075	1082	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC4	O15439	678	725	690	690	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC4	O15439	177	207	103	177	Alternative sequence	ID=VSP_057413;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCC4	O15439	102	177	103	177	Alternative sequence	ID=VSP_057413;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCC4	O15439	678	725	679	725	Alternative sequence	ID=VSP_035426;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
ABCC4	O15439	1245	1290	860	1325	Alternative sequence	ID=VSP_043284;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ABCC4	O15439	1122	1152	860	1325	Alternative sequence	ID=VSP_043284;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ABCC4	O15439	1070	1122	860	1325	Alternative sequence	ID=VSP_043284;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ABCC4	O15439	102	177	171	171	Natural variant	ID=VAR_046446;Note=C->G;Dbxref=dbSNP:rs4148460
ABCC4	O15439	177	207	184	184	Natural variant	ID=VAR_020241;Note=M->T;Dbxref=dbSNP:rs45454092
ABCC4	O15439	177	207	187	187	Natural variant	ID=VAR_020242;Note=Transport properties comparable to wild-type. G->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18300232;Dbxref=dbSNP:rs11568658,PMID:18300232
ABCC4	O15439	262	303	293	293	Natural variant	ID=VAR_046447;Note=K->E;Dbxref=dbSNP:rs11568684
ABCC4	O15439	387	421	403	403	Natural variant	ID=VAR_029122;Note=P->L;Dbxref=dbSNP:rs11568705
ABCC4	O15439	1122	1152	1142	1142	Natural variant	ID=VAR_029126;Note=10%25 reduced expression level compared to wild-type%3B transport properties comparable to wild-type. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18300232;Dbxref=dbSNP:rs11568644,PMID:18300232
ABCC4	O15439	678	725	703	703	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCC4	O15439	1122	1152	1139	1139	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCC10	Q5T3U5	709	742	1	1492	Chain	ID=PRO_0000253576;Note=Multidrug resistance-associated protein 7
ABCC10	Q5T3U5	709	742	598	824	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
LAMC3	Q9Y6N6	428	460	20	1575	Chain	ID=PRO_0000017079;Note=Laminin subunit gamma-3
LAMC3	Q9Y6N6	719	782	20	1575	Chain	ID=PRO_0000017079;Note=Laminin subunit gamma-3
LAMC3	Q9Y6N6	1165	1209	20	1575	Chain	ID=PRO_0000017079;Note=Laminin subunit gamma-3
LAMC3	Q9Y6N6	428	460	383	429	Domain	Note=Laminin EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	428	460	430	479	Domain	Note=Laminin EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	707	754	Domain	Note=Laminin EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	755	809	Domain	Note=Laminin EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	1165	1209	1014	1575	Region	Note=Domain II and I
LAMC3	Q9Y6N6	1165	1209	1201	1228	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMC3	Q9Y6N6	1165	1209	1185	1185	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMC3	Q9Y6N6	428	460	430	441	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	428	460	432	448	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	428	460	450	459	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	709	722	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	724	733	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	736	752	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	755	763	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	757	774	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	777	786	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMC3	Q9Y6N6	719	782	770	770	Natural variant	ID=VAR_056147;Note=R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10225960,ECO:0000269|Ref.3;Dbxref=dbSNP:rs3739510,PMID:10225960
LAPTM4A	Q15012	176	209	1	233	Chain	ID=PRO_0000096637;Note=Lysosomal-associated transmembrane protein 4A
LAPTM4A	Q15012	144	176	1	233	Chain	ID=PRO_0000096637;Note=Lysosomal-associated transmembrane protein 4A
LAPTM4A	Q15012	103	144	1	233	Chain	ID=PRO_0000096637;Note=Lysosomal-associated transmembrane protein 4A
LAPTM4A	Q15012	103	144	108	128	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAPTM4A	Q15012	176	209	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAPTM4A	Q15012	144	176	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L3	O95232	117	142	1	432	Chain	ID=PRO_0000058013;Note=Luc7-like protein 3
LUC7L3	O95232	177	231	1	432	Chain	ID=PRO_0000058013;Note=Luc7-like protein 3
LUC7L3	O95232	117	142	1	432	Chain	ID=PRO_0000058013;Note=Luc7-like protein 3
LUC7L3	O95232	177	231	1	432	Chain	ID=PRO_0000058013;Note=Luc7-like protein 3
LUC7L3	O95232	117	142	124	181	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L3	O95232	177	231	124	181	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L3	O95232	117	142	124	181	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L3	O95232	177	231	124	181	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LUC7L3	O95232	177	231	228	282	Compositional bias	Note=Glu-rich
LUC7L3	O95232	177	231	228	282	Compositional bias	Note=Glu-rich
LUC7L3	O95232	177	231	231	231	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LUC7L3	O95232	177	231	231	231	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LUC7L3	O95232	117	142	80	432	Alternative sequence	ID=VSP_018137;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LUC7L3	O95232	177	231	80	432	Alternative sequence	ID=VSP_018137;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LUC7L3	O95232	117	142	80	432	Alternative sequence	ID=VSP_018137;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LUC7L3	O95232	177	231	80	432	Alternative sequence	ID=VSP_018137;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LUC7L3	O95232	177	231	217	217	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
LUC7L3	O95232	177	231	217	217	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
LCN15	Q6UWW0	139	173	21	184	Chain	ID=PRO_0000317518;Note=Lipocalin-15
LCN15	Q6UWW0	139	173	83	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LCN15	Q6UWW0	139	173	152	152	Natural variant	ID=VAR_059453;Note=S->A;Dbxref=dbSNP:rs2297723
LCN15	Q6UWW0	139	173	164	164	Natural variant	ID=VAR_059454;Note=K->E;Dbxref=dbSNP:rs2297722
LCN15	Q6UWW0	139	173	131	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XST
LCN15	Q6UWW0	139	173	147	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XST
LCN15	Q6UWW0	139	173	157	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XST
LCN15	Q6UWW0	139	173	164	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XST
LCN15	Q6UWW0	139	173	167	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XST
LCLAT1	Q6UWP7	159	208	1	414	Chain	ID=PRO_0000291577;Note=Lysocardiolipin acyltransferase 1
LCLAT1	Q6UWP7	208	247	1	414	Chain	ID=PRO_0000291577;Note=Lysocardiolipin acyltransferase 1
LCLAT1	Q6UWP7	208	247	221	221	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LCLAT1	Q6UWP7	159	208	206	206	Mutagenesis	Note=Abolishes LPIAT and LPGAT activities. D->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16620771,ECO:0000269|PubMed:19075029;Dbxref=PMID:16620771,PMID:19075029
LCLAT1	Q6UWP7	159	208	206	206	Mutagenesis	Note=Does not increase enzyme activity. D->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16620771,ECO:0000269|PubMed:19075029;Dbxref=PMID:16620771,PMID:19075029
LCLAT1	Q6UWP7	159	208	207	207	Mutagenesis	Note=Abolishes LPIAT activity. No effect on LPGAT activity. L->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19075029;Dbxref=PMID:19075029
LCORL	Q8N3X6	143	227	1	602	Chain	ID=PRO_0000310463;Note=Ligand-dependent nuclear receptor corepressor-like protein
LCORL	Q8N3X6	51	73	1	602	Chain	ID=PRO_0000310463;Note=Ligand-dependent nuclear receptor corepressor-like protein
LCORL	Q8N3X6	143	227	1	389	Alternative sequence	ID=VSP_029287;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LCORL	Q8N3X6	51	73	1	389	Alternative sequence	ID=VSP_029287;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LEMD1	Q68G75	27	68	1	181	Chain	ID=PRO_0000285247;Note=LEM domain-containing protein 1
LEMD1	Q68G75	27	68	1	45	Domain	Note=LEM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00313
LEMD1	Q68G75	27	68	28	69	Alternative sequence	ID=VSP_024846;Note=In isoform 3. PSTRKLYEKKLVQLLVSPPCAPPVMNGPRELDGAQDSDDSEE->Q;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15254688;Dbxref=PMID:15254688
LEMD1	Q68G75	27	68	28	67	Alternative sequence	ID=VSP_024847;Note=In isoform 6. PSTRKLYEKKLVQLLVSPPCAPPVMNGPRELDGAQDSDDS->RGLQEHQAPESHMGLSPKRETTARKTRLSRAGEKKVSQWA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15254688;Dbxref=PMID:15254688
LEMD1	Q68G75	27	68	28	29	Alternative sequence	ID=VSP_024848;Note=In isoform 2. PS->LA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15254688;Dbxref=PMID:15254688
LEMD1	Q68G75	27	68	30	181	Alternative sequence	ID=VSP_024849;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15254688;Dbxref=PMID:15254688
LEMD1	Q68G75	27	68	68	181	Alternative sequence	ID=VSP_024850;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15254688;Dbxref=PMID:15254688
LEMD2	Q8NC56	385	419	2	503	Chain	ID=PRO_0000285249;Note=LEM domain-containing protein 2
LEMD2	Q8NC56	385	419	377	397	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LEMD2	Q8NC56	385	419	405	408	Compositional bias	Note=Poly-Glu
MTMR3	Q13615	186	223	1	1198	Chain	ID=PRO_0000094936;Note=Myotubularin-related protein 3
MTMR3	Q13615	1075	1112	1	1198	Chain	ID=PRO_0000094936;Note=Myotubularin-related protein 3
MTMR3	Q13615	186	223	155	576	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR3	Q13615	1075	1112	1076	1112	Alternative sequence	ID=VSP_007781;Note=In isoform A and isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTMR3	Q13615	186	223	221	221	Natural variant	ID=VAR_035656;Note=In a breast cancer sample%3B somatic mutation. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MTMR4	Q9NYA4	495	552	1	1195	Chain	ID=PRO_0000304809;Note=Myotubularin-related protein 4
MTMR4	Q9NYA4	31	70	1	1195	Chain	ID=PRO_0000304809;Note=Myotubularin-related protein 4
MTMR4	Q9NYA4	495	552	153	570	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
LPGAT1	Q92604	119	151	1	370	Chain	ID=PRO_0000208204;Note=Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
LPGAT1	Q92604	119	151	1	370	Chain	ID=PRO_0000208204;Note=Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
MTMR6	Q9Y217	197	242	1	621	Chain	ID=PRO_0000094939;Note=Myotubularin-related protein 6
MTMR6	Q9Y217	197	242	124	499	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR6	Q9Y217	197	242	199	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YF0
MTMR6	Q9Y217	197	242	215	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YF0
MTMR6	Q9Y217	197	242	234	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YF0
LGI4	Q8N135	105	128	20	537	Chain	ID=PRO_0000017712;Note=Leucine-rich repeat LGI family member 4
LGI4	Q8N135	81	104	20	537	Chain	ID=PRO_0000017712;Note=Leucine-rich repeat LGI family member 4
LGI4	Q8N135	81	104	77	98	Repeat	Note=LRR 2
LGI4	Q8N135	105	128	101	122	Repeat	Note=LRR 3
LGI4	Q8N135	81	104	101	122	Repeat	Note=LRR 3
LGI4	Q8N135	105	128	125	146	Repeat	Note=LRR 4
LIMK2	P53671	121	183	1	638	Chain	ID=PRO_0000075809;Note=LIM domain kinase 2
LIMK2	P53671	347	376	1	638	Chain	ID=PRO_0000075809;Note=LIM domain kinase 2
LIMK2	P53671	420	439	1	638	Chain	ID=PRO_0000075809;Note=LIM domain kinase 2
LIMK2	P53671	439	461	1	638	Chain	ID=PRO_0000075809;Note=LIM domain kinase 2
LIMK2	P53671	121	183	72	124	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
LIMK2	P53671	121	183	152	239	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
LIMK2	P53671	347	376	331	608	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LIMK2	P53671	420	439	331	608	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LIMK2	P53671	439	461	331	608	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LIMK2	P53671	439	461	451	451	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
LIMK2	P53671	347	376	360	360	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LIMK2	P53671	121	183	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X6A
LIMK2	P53671	121	183	122	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X6A
LIMK2	P53671	347	376	345	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIMK2	P53671	347	376	351	353	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIMK2	P53671	347	376	356	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIMK2	P53671	347	376	367	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIMK2	P53671	420	439	425	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIMK2	P53671	439	461	425	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIMK2	P53671	439	461	456	459	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NXD
LIN54	Q6MZP7	569	615	1	749	Chain	ID=PRO_0000341389;Note=Protein lin-54 homolog
LIN54	Q6MZP7	569	615	1	749	Chain	ID=PRO_0000341389;Note=Protein lin-54 homolog
LIN54	Q6MZP7	569	615	521	634	Domain	Note=CRC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00971
LIN54	Q6MZP7	569	615	521	634	Domain	Note=CRC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00971
LIN54	Q6MZP7	569	615	583	596	Region	Note=Linker;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	583	596	Region	Note=Linker;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	599	612	Region	Note=DNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	599	612	Region	Note=DNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	599	599	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	599	599	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	599	599	Metal binding	Note=Zinc 5;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	599	599	Metal binding	Note=Zinc 5;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	601	601	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	601	601	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	606	606	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	606	606	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	606	606	Metal binding	Note=Zinc 6;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	606	606	Metal binding	Note=Zinc 6;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	611	611	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	611	611	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	613	613	Metal binding	Note=Zinc 5;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	613	613	Metal binding	Note=Zinc 5;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	574	574	Site	Note=Interaction with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	574	574	Site	Note=Interaction with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	610	610	Site	Note=Critical for interaction with target DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	610	610	Site	Note=Critical for interaction with target DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	244	749	Alternative sequence	ID=VSP_034276;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIN54	Q6MZP7	569	615	244	749	Alternative sequence	ID=VSP_034276;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIN54	Q6MZP7	569	615	610	610	Mutagenesis	Note=Loss of DNA-binding. Y->A%2CF%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	610	610	Mutagenesis	Note=Loss of DNA-binding. Y->A%2CF%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27465258;Dbxref=PMID:27465258
LIN54	Q6MZP7	569	615	561	574	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	561	574	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	576	579	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	576	579	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	602	604	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	602	604	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	612	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
LIN54	Q6MZP7	569	615	612	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FD3
IVD	P26440	51	81	33	426	Chain	ID=PRO_0000000531;Note=Isovaleryl-CoA dehydrogenase%2C mitochondrial
IVD	P26440	51	81	58	58	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHI5
IVD	P26440	51	81	58	58	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHI5
IVD	P26440	51	81	67	67	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHI5
IVD	P26440	51	81	67	67	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHI5
IVD	P26440	51	81	78	78	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
IVD	P26440	51	81	78	78	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHI5
IVD	P26440	51	81	52	81	Alternative sequence	ID=VSP_045193;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IVD	P26440	51	81	53	53	Natural variant	ID=VAR_015960;Note=In IVA. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9665741;Dbxref=PMID:9665741
IVD	P26440	51	81	72	72	Natural variant	ID=VAR_015961;Note=In IVA. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9665741;Dbxref=PMID:9665741
IVD	P26440	51	81	47	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IVH
IVD	P26440	51	81	64	67	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IVH
IVD	P26440	51	81	68	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IVH
IVD	P26440	51	81	80	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IVH
JMJD8	Q96S16	193	238	24	264	Chain	ID=PRO_0000344531;Note=JmjC domain-containing protein 8;Ontology_term=ECO:0000255;evidence=ECO:0000255
JMJD8	Q96S16	130	170	24	264	Chain	ID=PRO_0000344531;Note=JmjC domain-containing protein 8;Ontology_term=ECO:0000255;evidence=ECO:0000255
JMJD8	Q96S16	29	58	24	264	Chain	ID=PRO_0000344531;Note=JmjC domain-containing protein 8;Ontology_term=ECO:0000255;evidence=ECO:0000255
JMJD8	Q96S16	193	238	131	264	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JMJD8	Q96S16	130	170	131	264	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JMJD8	Q96S16	130	170	130	130	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
JMJD8	Q96S16	130	170	140	140	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
JMJD8	Q96S16	193	238	209	209	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
JMJD8	Q96S16	29	58	30	59	Alternative sequence	ID=VSP_034849;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
JMJD8	Q96S16	130	170	158	158	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
JMJD8	Q96S16	193	238	207	207	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
JMJD4	Q9H9V9	320	369	1	463	Chain	ID=PRO_0000291959;Note=JmjC domain-containing protein 4
JMJD4	Q9H9V9	189	230	1	463	Chain	ID=PRO_0000291959;Note=JmjC domain-containing protein 4
JMJD4	Q9H9V9	320	369	188	347	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JMJD4	Q9H9V9	189	230	188	347	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JMJD4	Q9H9V9	320	369	354	369	Alternative sequence	ID=VSP_026324;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA1755	Q5JYT7	893	967	1	1200	Chain	ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755
KIAA1755	Q5JYT7	684	723	1	1200	Chain	ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755
KIAA1755	Q5JYT7	655	684	1	1200	Chain	ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755
KIAA1755	Q5JYT7	516	582	1	1200	Chain	ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755
KIAA1755	Q5JYT7	893	967	940	940	Natural variant	ID=VAR_038504;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11214970;Dbxref=dbSNP:rs760998,PMID:11214970
KRT79	Q5XKE5	340	382	1	535	Chain	ID=PRO_0000314893;Note=Keratin%2C type II cytoskeletal 79
KRT79	Q5XKE5	340	382	142	457	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT79	Q5XKE5	340	382	315	453	Region	Note=Coil 2
KANK1	Q14678	12	899	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	899	965	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	1002	1081	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	1232	1299	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	12	899	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	899	965	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	1002	1081	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	1232	1299	1	1352	Chain	ID=PRO_0000066911;Note=KN motif and ankyrin repeat domain-containing protein 1
KANK1	Q14678	1232	1299	1233	1262	Repeat	Note=ANK 3
KANK1	Q14678	1232	1299	1233	1262	Repeat	Note=ANK 3
KANK1	Q14678	1232	1299	1266	1298	Repeat	Note=ANK 4
KANK1	Q14678	1232	1299	1266	1298	Repeat	Note=ANK 4
KANK1	Q14678	12	899	291	467	Region	Note=Interaction with KIF21A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19559006;Dbxref=PMID:19559006
KANK1	Q14678	12	899	291	467	Region	Note=Interaction with KIF21A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19559006;Dbxref=PMID:19559006
KANK1	Q14678	1232	1299	1156	1308	Region	Note=Interaction with KIF21A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19559006;Dbxref=PMID:19559006
KANK1	Q14678	1232	1299	1156	1308	Region	Note=Interaction with KIF21A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19559006;Dbxref=PMID:19559006
KANK1	Q14678	12	899	258	316	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK1	Q14678	12	899	258	316	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK1	Q14678	12	899	361	395	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK1	Q14678	12	899	361	395	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK1	Q14678	12	899	446	500	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK1	Q14678	12	899	446	500	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KANK1	Q14678	12	899	43	52	Motif	Note=Nuclear export signal 1 (NES 1)
KANK1	Q14678	12	899	43	52	Motif	Note=Nuclear export signal 1 (NES 1)
KANK1	Q14678	12	899	65	68	Motif	Note=Nuclear localization signal 1 (NLS 1)
KANK1	Q14678	12	899	65	68	Motif	Note=Nuclear localization signal 1 (NLS 1)
KANK1	Q14678	12	899	125	134	Motif	Note=Nuclear export signal 2 (NES 2)
KANK1	Q14678	12	899	125	134	Motif	Note=Nuclear export signal 2 (NES 2)
KANK1	Q14678	12	899	613	622	Motif	Note=Nuclear export signal 3 (NES 3)
KANK1	Q14678	12	899	613	622	Motif	Note=Nuclear export signal 3 (NES 3)
KANK1	Q14678	12	899	186	186	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK1	Q14678	12	899	186	186	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KANK1	Q14678	12	899	325	325	Modified residue	Note=Phosphoserine%3B by PKB;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:18458160;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163,PMID:18458160
KANK1	Q14678	12	899	325	325	Modified residue	Note=Phosphoserine%3B by PKB;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:18458160;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163,PMID:18458160
KANK1	Q14678	12	899	1	158	Alternative sequence	ID=VSP_043958;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KANK1	Q14678	12	899	1	158	Alternative sequence	ID=VSP_043958;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KANK1	Q14678	12	899	206	206	Natural variant	ID=VAR_026212;Note=N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857145,PMID:15489334
KANK1	Q14678	12	899	206	206	Natural variant	ID=VAR_026212;Note=N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857145,PMID:15489334
KANK1	Q14678	12	899	210	210	Natural variant	ID=VAR_048298;Note=H->Q;Dbxref=dbSNP:rs28374506
KANK1	Q14678	12	899	210	210	Natural variant	ID=VAR_048298;Note=H->Q;Dbxref=dbSNP:rs28374506
KANK1	Q14678	12	899	321	321	Natural variant	ID=VAR_048299;Note=K->R;Dbxref=dbSNP:rs17857159
KANK1	Q14678	12	899	321	321	Natural variant	ID=VAR_048299;Note=K->R;Dbxref=dbSNP:rs17857159
KANK1	Q14678	12	899	432	432	Natural variant	ID=VAR_026213;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs4465020,PMID:15489334
KANK1	Q14678	12	899	432	432	Natural variant	ID=VAR_026213;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs4465020,PMID:15489334
KANK1	Q14678	12	899	464	464	Natural variant	ID=VAR_016697;Note=S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8724849;Dbxref=dbSNP:rs912174,PMID:8724849
KANK1	Q14678	12	899	464	464	Natural variant	ID=VAR_016697;Note=S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8724849;Dbxref=dbSNP:rs912174,PMID:8724849
KANK1	Q14678	12	899	664	664	Natural variant	ID=VAR_048300;Note=A->V;Dbxref=dbSNP:rs3824421
KANK1	Q14678	12	899	664	664	Natural variant	ID=VAR_048300;Note=A->V;Dbxref=dbSNP:rs3824421
KANK1	Q14678	12	899	667	667	Natural variant	ID=VAR_048301;Note=R->H;Dbxref=dbSNP:rs3824420
KANK1	Q14678	12	899	667	667	Natural variant	ID=VAR_048301;Note=R->H;Dbxref=dbSNP:rs3824420
KANK1	Q14678	899	965	901	901	Natural variant	ID=VAR_048302;Note=N->S;Dbxref=dbSNP:rs12352313
KANK1	Q14678	899	965	901	901	Natural variant	ID=VAR_048302;Note=N->S;Dbxref=dbSNP:rs12352313
KANK1	Q14678	1002	1081	1055	1055	Natural variant	ID=VAR_048303;Note=I->T;Dbxref=dbSNP:rs34832656
KANK1	Q14678	1002	1081	1055	1055	Natural variant	ID=VAR_048303;Note=I->T;Dbxref=dbSNP:rs34832656
KANK1	Q14678	12	899	43	43	Mutagenesis	Note=Nuclear localization%3B when associated A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	43	43	Mutagenesis	Note=Nuclear localization%3B when associated A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	52	52	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	52	52	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	65	68	Mutagenesis	Note=Enhanced cytoplasmic localization%3B when associated with 979-A--A-981 and 991-A-A-992. KRRK->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	65	68	Mutagenesis	Note=Enhanced cytoplasmic localization%3B when associated with 979-A--A-981 and 991-A-A-992. KRRK->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	125	125	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-129%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	125	125	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-129%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	129	129	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	129	129	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-134%3B A-613%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	134	134	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-613%3B A-616%3B A-620 and A-622. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	134	134	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-613%3B A-616%3B A-620 and A-622. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	325	325	Mutagenesis	Note=Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB%3B YWHAG%3B YWHAE%3B YWHAH%3B YWHAQ%3B YWHAZ and SFN. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18458160;Dbxref=PMID:18458160
KANK1	Q14678	12	899	325	325	Mutagenesis	Note=Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB%3B YWHAG%3B YWHAE%3B YWHAH%3B YWHAQ%3B YWHAZ and SFN. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18458160;Dbxref=PMID:18458160
KANK1	Q14678	12	899	613	613	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	613	613	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-616%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	616	616	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	616	616	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-620 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	620	620	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	620	620	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616 and A-622. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	622	622	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616 and A-620. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	12	899	622	622	Mutagenesis	Note=Nuclear localization%3B when associated A-43%3B A-52%3B A-125%3B A-129%3B A-134%3B A-613%3B A-616 and A-620. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16968744;Dbxref=PMID:16968744
KANK1	Q14678	1232	1299	1231	1234	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1231	1234	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1237	1243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1237	1243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1247	1255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1247	1255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1270	1277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1270	1277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1280	1287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
KANK1	Q14678	1232	1299	1280	1287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YBU
PRKAR2A	P13861	291	313	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	232	266	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	117	145	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	87	99	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	291	313	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	232	266	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	117	145	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	87	99	2	404	Chain	ID=PRO_0000205385;Note=cAMP-dependent protein kinase type II-alpha regulatory subunit
PRKAR2A	P13861	232	266	139	260	Nucleotide binding	Note=cAMP 1
PRKAR2A	P13861	117	145	139	260	Nucleotide binding	Note=cAMP 1
PRKAR2A	P13861	232	266	139	260	Nucleotide binding	Note=cAMP 1
PRKAR2A	P13861	117	145	139	260	Nucleotide binding	Note=cAMP 1
PRKAR2A	P13861	291	313	261	404	Nucleotide binding	Note=cAMP 2
PRKAR2A	P13861	232	266	261	404	Nucleotide binding	Note=cAMP 2
PRKAR2A	P13861	291	313	261	404	Nucleotide binding	Note=cAMP 2
PRKAR2A	P13861	232	266	261	404	Nucleotide binding	Note=cAMP 2
PRKAR2A	P13861	117	145	2	138	Region	Note=Dimerization and phosphorylation
PRKAR2A	P13861	87	99	2	138	Region	Note=Dimerization and phosphorylation
PRKAR2A	P13861	117	145	2	138	Region	Note=Dimerization and phosphorylation
PRKAR2A	P13861	87	99	2	138	Region	Note=Dimerization and phosphorylation
PRKAR2A	P13861	87	99	99	99	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18318008,PMID:18669648,PMID:19690332,PMID:23186163
PRKAR2A	P13861	87	99	99	99	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18318008,PMID:18669648,PMID:19690332,PMID:23186163
PRKAR2A	P13861	291	313	292	313	Alternative sequence	ID=VSP_056821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
PRKAR2A	P13861	291	313	292	313	Alternative sequence	ID=VSP_056821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
KANSL2	Q9H9L4	409	449	1	492	Chain	ID=PRO_0000278292;Note=KAT8 regulatory NSL complex subunit 2
KANSL2	Q9H9L4	409	449	156	492	Alternative sequence	ID=VSP_042531;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
KANSL2	Q9H9L4	409	449	445	445	Natural variant	ID=VAR_030768;Note=P->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3741628,PMID:14702039,PMID:15489334
PRKACA	P17612	255	310	2	351	Chain	ID=PRO_0000086052;Note=cAMP-dependent protein kinase catalytic subunit alpha
PRKACA	P17612	182	214	2	351	Chain	ID=PRO_0000086052;Note=cAMP-dependent protein kinase catalytic subunit alpha
PRKACA	P17612	79	112	2	351	Chain	ID=PRO_0000086052;Note=cAMP-dependent protein kinase catalytic subunit alpha
PRKACA	P17612	255	310	44	298	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKACA	P17612	182	214	44	298	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKACA	P17612	79	112	44	298	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKACA	P17612	255	310	299	351	Domain	Note=AGC-kinase C-terminal
PRKACA	P17612	182	214	196	196	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12372837;Dbxref=PMID:12372837
PRKACA	P17612	182	214	198	198	Modified residue	Note=Phosphothreonine%3B by PDPK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12372837,ECO:0000269|PubMed:16765046,ECO:0000269|PubMed:20137943,ECO:0000269|PubMed:20481595,ECO:0000269|PubMed:20732331,ECO:0000269|PubMed:21774789,ECO:0000269|Ref.41;Dbxref=PMID:12372837,PMID:16765046,PMID:20137943,PMID:20481595,PMID:20732331,PMID:21774789
PRKACA	P17612	182	214	206	206	Natural variant	ID=VAR_071707;Note=In PPNAD4%3B somatic mutation%3B the mutation results in cAMP-independent basal protein kinase activity and constitutive activation of protein kinase A. L->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24571724,ECO:0000269|PubMed:24700472,ECO:0000269|PubMed:24747643,ECO:0000269|PubMed:24855271;Dbxref=dbSNP:rs386352352,PMID:24571724,PMID:24700472,PMID:24747643,PMID:24855271
PRKACA	P17612	255	310	264	264	Natural variant	ID=VAR_040593;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35635531,PMID:17344846
PRKACA	P17612	79	112	96	96	Mutagenesis	Note=Enhanced basal kinase activity%3B when associated with R-48%2C L-121%2C A-124%2C K-182 and A-184. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21774789;Dbxref=PMID:21774789
PRKACA	P17612	182	214	182	182	Mutagenesis	Note=Enhanced basal kinase activity%3B when associated with R-48%2C Q-96%2C L-121%2C A-124 and A-184. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21774789;Dbxref=PMID:21774789
PRKACA	P17612	182	214	184	184	Mutagenesis	Note=Enhanced basal kinase activity%3B when associated with R-48%2C Q-96%2C L-121%2C A-124 and K-182. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21774789;Dbxref=PMID:21774789
PRKACA	P17612	182	214	195	195	Mutagenesis	Note=No phosphorylation. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12372837;Dbxref=PMID:12372837
PRKACA	P17612	182	214	201	201	Mutagenesis	Note=No phosphorylation. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12372837;Dbxref=PMID:12372837
PRKACA	P17612	182	214	202	202	Mutagenesis	Note=No phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12372837;Dbxref=PMID:12372837
PRKACA	P17612	182	214	205	205	Mutagenesis	Note=Loss of allosteric regulation. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18178622;Dbxref=PMID:18178622
PRKACA	P17612	79	112	77	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	79	112	86	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	79	112	107	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	182	214	181	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	182	214	186	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UJ2
PRKACA	P17612	182	214	203	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	182	214	208	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	182	214	212	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZJ
PRKACA	P17612	255	310	264	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	255	310	278	280	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	255	310	282	284	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZF
PRKACA	P17612	255	310	286	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	255	310	290	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	255	310	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
PRKACA	P17612	255	310	303	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WB8
KAT2A	Q92830	393	430	2	837	Chain	ID=PRO_0000211202;Note=Histone acetyltransferase KAT2A
KAT2A	Q92830	393	430	1	410	Alternative sequence	ID=VSP_000556;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KATNAL2	Q8IYT4	242	275	1	538	Chain	ID=PRO_0000333792;Note=Katanin p60 ATPase-containing subunit A-like 2
KBTBD12	Q3ZCT8	497	563	1	623	Chain	ID=PRO_0000324766;Note=Kelch repeat and BTB domain-containing protein 12
KBTBD12	Q3ZCT8	497	563	1	623	Chain	ID=PRO_0000324766;Note=Kelch repeat and BTB domain-containing protein 12
KBTBD12	Q3ZCT8	497	563	494	547	Repeat	Note=Kelch 3
KBTBD12	Q3ZCT8	497	563	494	547	Repeat	Note=Kelch 3
KBTBD12	Q3ZCT8	497	563	553	603	Repeat	Note=Kelch 4
KBTBD12	Q3ZCT8	497	563	553	603	Repeat	Note=Kelch 4
KBTBD12	Q3ZCT8	497	563	547	547	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KBTBD12	Q3ZCT8	497	563	547	547	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSNK1D	P48730	25	62	1	415	Chain	ID=PRO_0000192833;Note=Casein kinase I isoform delta
CSNK1D	P48730	25	62	9	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK1D	P48730	25	62	38	38	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK1D	P48730	25	62	44	44	Natural variant	ID=VAR_029075;Note=In FASPS2%3B strongly reduces kinase activity. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15800623,ECO:0000269|PubMed:23636092;Dbxref=dbSNP:rs104894561,PMID:15800623,PMID:23636092
CSNK1D	P48730	25	62	46	46	Natural variant	ID=VAR_069801;Note=In FASPS2%3B strongly reduces kinase activity. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23636092;Dbxref=dbSNP:rs397514693,PMID:23636092
CSNK1D	P48730	25	62	38	38	Mutagenesis	Note=Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11161704;Dbxref=PMID:11161704
CSNK1D	P48730	25	62	21	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWC
CSNK1D	P48730	25	62	29	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWC
CSNK1D	P48730	25	62	33	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWC
CSNK1D	P48730	25	62	44	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWC
CSNK1D	P48730	25	62	49	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWC
KCTD17	Q8N5Z5	244	268	1	321	Chain	ID=PRO_0000247841;Note=BTB/POZ domain-containing protein KCTD17
KCTD17	Q8N5Z5	244	268	203	246	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KCTD17	Q8N5Z5	244	268	258	311	Compositional bias	Note=Pro-rich
KCTD17	Q8N5Z5	244	268	245	268	Alternative sequence	ID=VSP_020072;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KCTD19	Q17RG1	855	889	1	926	Chain	ID=PRO_0000313587;Note=BTB/POZ domain-containing protein KCTD19
KCNIP1	Q9NZI2	20	31	1	227	Chain	ID=PRO_0000073818;Note=Kv channel-interacting protein 1
KCNIP1	Q9NZI2	20	31	1	39	Alternative sequence	ID=VSP_015043;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
KCNIP1	Q9NZI2	20	31	1	31	Alternative sequence	ID=VSP_041511;Note=In isoform 4. MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQR->MSGCSKRCKLGFVKFAQTIFKLITGTLSK;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16112838;Dbxref=PMID:14702039,PMID:16112838
KCNIP1	Q9NZI2	20	31	21	31	Alternative sequence	ID=VSP_015044;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10676964,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16112838,ECO:0000303|Ref.2;Dbxref=PMID:10676964,PMID:15489334,PMID:16112838
KCNN1	Q92952	353	390	1	543	Chain	ID=PRO_0000155007;Note=Small conductance calcium-activated potassium channel protein 1
KCNN1	Q92952	353	390	346	366	Transmembrane	Note=Helical%3B Name%3DSegment S6;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNN1	Q92952	353	390	384	463	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
KCMF1	Q9P0J7	5	61	2	381	Chain	ID=PRO_0000349219;Note=E3 ubiquitin-protein ligase KCMF1
KCMF1	Q9P0J7	5	61	3	50	Zinc finger	Note=ZZ-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00228
KCNT2	Q6UVM3	759	782	1	1135	Chain	ID=PRO_0000312503;Note=Potassium channel subfamily T member 2
KCNT2	Q6UVM3	468	517	1	1135	Chain	ID=PRO_0000312503;Note=Potassium channel subfamily T member 2
KCNT2	Q6UVM3	128	153	1	1135	Chain	ID=PRO_0000312503;Note=Potassium channel subfamily T member 2
KCNT2	Q6UVM3	128	153	123	137	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT2	Q6UVM3	128	153	138	158	Transmembrane	Note=Helical%3B Name%3DSegment S3;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT2	Q6UVM3	759	782	278	1135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT2	Q6UVM3	468	517	278	1135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNT2	Q6UVM3	468	517	422	543	Domain	Note=RCK N-terminal
KCNT2	Q6UVM3	128	153	129	153	Alternative sequence	ID=VSP_029852;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KCNT2	Q6UVM3	468	517	468	468	Alternative sequence	ID=VSP_029853;Note=In isoform 4. Q->QCVCLCCR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KCNT2	Q6UVM3	468	517	469	518	Alternative sequence	ID=VSP_029854;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCNT2	Q6UVM3	759	782	760	783	Alternative sequence	ID=VSP_029855;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PRKG1	Q13976	584	604	2	671	Chain	ID=PRO_0000086115;Note=cGMP-dependent protein kinase 1
PRKG1	Q13976	596	616	2	671	Chain	ID=PRO_0000086115;Note=cGMP-dependent protein kinase 1
PRKG1	Q13976	584	604	360	619	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKG1	Q13976	596	616	360	619	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKG1	Q13976	584	604	585	594	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0T
PRKG1	Q13976	584	604	599	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0T
PRKG1	Q13976	596	616	599	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0T
PRKG1	Q13976	596	616	607	610	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0T
PRKG1	Q13976	596	616	611	614	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0T
KHDRBS1	Q07666	169	208	1	443	Chain	ID=PRO_0000050124;Note=KH domain-containing%2C RNA-binding%2C signal transduction-associated protein 1
KHDRBS1	Q07666	169	208	171	197	Domain	Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
KHDRBS1	Q07666	169	208	100	260	Region	Note=Involved in homodimerization;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26758068;Dbxref=PMID:26758068
KHDRBS1	Q07666	169	208	175	175	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
KHDRBS1	Q07666	169	208	183	183	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KHDRBS1	Q07666	169	208	175	175	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KHDRBS1	Q07666	169	208	169	207	Alternative sequence	ID=VSP_051720;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9013542;Dbxref=PMID:9013542
KHNYN	O15037	562	595	1	678	Chain	ID=PRO_0000084290;Note=Protein KHNYN
KHNYN	O15037	562	595	1	678	Chain	ID=PRO_0000084290;Note=Protein KHNYN
KHNYN	O15037	562	595	1	678	Chain	ID=PRO_0000084290;Note=Protein KHNYN
KIF18A	Q8NI77	475	530	1	898	Chain	ID=PRO_0000125458;Note=Kinesin-like protein KIF18A
KIF18A	Q8NI77	196	233	1	898	Chain	ID=PRO_0000125458;Note=Kinesin-like protein KIF18A
KIF18A	Q8NI77	196	233	11	355	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF18A	Q8NI77	196	233	200	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRE
KIF18A	Q8NI77	196	233	229	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRE
KIF4A	O95239	477	496	1	1232	Chain	ID=PRO_0000125437;Note=Chromosome-associated kinesin KIF4A
KIF4A	O95239	930	966	1	1232	Chain	ID=PRO_0000125437;Note=Chromosome-associated kinesin KIF4A
KIF4A	O95239	992	1024	1	1232	Chain	ID=PRO_0000125437;Note=Chromosome-associated kinesin KIF4A
KIF4A	O95239	1085	1124	1	1232	Chain	ID=PRO_0000125437;Note=Chromosome-associated kinesin KIF4A
KIF4A	O95239	1124	1165	1	1232	Chain	ID=PRO_0000125437;Note=Chromosome-associated kinesin KIF4A
KIF4A	O95239	930	966	663	1232	Region	Note=Interaction with PRC1
KIF4A	O95239	992	1024	663	1232	Region	Note=Interaction with PRC1
KIF4A	O95239	1085	1124	663	1232	Region	Note=Interaction with PRC1
KIF4A	O95239	1124	1165	663	1232	Region	Note=Interaction with PRC1
KIF4A	O95239	992	1024	1000	1232	Region	Note=Globular
KIF4A	O95239	1085	1124	1000	1232	Region	Note=Globular
KIF4A	O95239	1124	1165	1000	1232	Region	Note=Globular
KIF4A	O95239	477	496	350	999	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF4A	O95239	930	966	350	999	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF4A	O95239	992	1024	350	999	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF4A	O95239	930	966	951	951	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF4A	O95239	992	1024	995	995	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18318008;Dbxref=PMID:18318008
KIF4A	O95239	992	1024	1001	1001	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18318008,PMID:18669648,PMID:20068231
KIF4A	O95239	992	1024	1013	1013	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF4A	O95239	992	1024	1017	1017	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF4A	O95239	1124	1165	1126	1126	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIF4A	O95239	1085	1124	1086	1127	Alternative sequence	ID=VSP_013375;Note=In isoform 2. CSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSL->VLLLTPVISALWEAEARGLLEARSSRPAWATWRDPVSTKPKN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIF4A	O95239	1124	1165	1086	1127	Alternative sequence	ID=VSP_013375;Note=In isoform 2. CSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSL->VLLLTPVISALWEAEARGLLEARSSRPAWATWRDPVSTKPKN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIF4A	O95239	1124	1165	1128	1232	Alternative sequence	ID=VSP_013376;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIF4A	O95239	477	496	491	491	Natural variant	ID=VAR_049693;Note=A->V;Dbxref=dbSNP:rs2297871
KIF4A	O95239	930	966	958	958	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF4A	O95239	930	966	960	960	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF4A	O95239	992	1024	996	997	Sequence conflict	Note=LL->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF4A	O95239	992	1024	1003	1014	Sequence conflict	Note=QKHLPKDTLLSP->RTLPRIPFYLQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF4A	O95239	992	1024	1022	1022	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF4A	O95239	1124	1165	1138	1138	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF24	Q5T7B8	481	505	1	1368	Chain	ID=PRO_0000278248;Note=Kinesin-like protein KIF24
KIF24	Q5T7B8	304	375	1	1368	Chain	ID=PRO_0000278248;Note=Kinesin-like protein KIF24
KIF24	Q5T7B8	481	505	223	546	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF24	Q5T7B8	304	375	223	546	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF24	Q5T7B8	304	375	313	320	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF24	Q5T7B8	481	505	209	1368	Alternative sequence	ID=VSP_023211;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF24	Q5T7B8	304	375	209	1368	Alternative sequence	ID=VSP_023211;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF24	Q5T7B8	304	375	272	405	Alternative sequence	ID=VSP_023210;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF24	Q5T7B8	481	505	483	485	Mutagenesis	Note=Impairs ability to suppress cilia formation. KEC->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21620453;Dbxref=PMID:21620453
KIF21B	O75037	1268	1280	1	1637	Chain	ID=PRO_0000125464;Note=Kinesin-like protein KIF21B
KIF21B	O75037	244	300	1	1637	Chain	ID=PRO_0000125464;Note=Kinesin-like protein KIF21B
KIF21B	O75037	244	300	8	370	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF21B	O75037	1268	1280	1269	1281	Alternative sequence	ID=VSP_016217;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455484;Dbxref=PMID:15489334,PMID:9455484
KIF27	Q86VH2	1185	1240	1	1401	Chain	ID=PRO_0000307143;Note=Kinesin-like protein KIF27
KIF27	Q86VH2	978	1050	1	1401	Chain	ID=PRO_0000307143;Note=Kinesin-like protein KIF27
KIF27	Q86VH2	919	978	1	1401	Chain	ID=PRO_0000307143;Note=Kinesin-like protein KIF27
KIF27	Q86VH2	881	919	1	1401	Chain	ID=PRO_0000307143;Note=Kinesin-like protein KIF27
KIF27	Q86VH2	815	881	1	1401	Chain	ID=PRO_0000307143;Note=Kinesin-like protein KIF27
KIF27	Q86VH2	881	919	705	886	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF27	Q86VH2	815	881	705	886	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF27	Q86VH2	978	1050	916	1070	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF27	Q86VH2	919	978	916	1070	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF27	Q86VH2	881	919	916	1070	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF27	Q86VH2	1185	1240	1190	1219	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF27	Q86VH2	978	1050	999	999	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7M6Z5
KIF27	Q86VH2	881	919	816	881	Alternative sequence	ID=VSP_028603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12783626;Dbxref=PMID:12783626
KIF27	Q86VH2	815	881	816	881	Alternative sequence	ID=VSP_028603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12783626;Dbxref=PMID:12783626
KIF27	Q86VH2	978	1050	882	978	Alternative sequence	ID=VSP_028604;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12783626;Dbxref=PMID:12783626
KIF27	Q86VH2	919	978	882	978	Alternative sequence	ID=VSP_028604;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12783626;Dbxref=PMID:12783626
KIF27	Q86VH2	881	919	882	978	Alternative sequence	ID=VSP_028604;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12783626;Dbxref=PMID:12783626
KIF27	Q86VH2	881	919	882	896	Alternative sequence	ID=VSP_028605;Note=In isoform 4. EIQLKTGQEEGLKPK->VILSYIPAKYNMKC;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF27	Q86VH2	1185	1240	897	1401	Alternative sequence	ID=VSP_028606;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF27	Q86VH2	978	1050	897	1401	Alternative sequence	ID=VSP_028606;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF27	Q86VH2	919	978	897	1401	Alternative sequence	ID=VSP_028606;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF27	Q86VH2	881	919	897	1401	Alternative sequence	ID=VSP_028606;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF27	Q86VH2	978	1050	1036	1036	Natural variant	ID=VAR_061286;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs55654273,PMID:17974005
KIF9	Q9HAQ2	505	569	1	790	Chain	ID=PRO_0000125442;Note=Kinesin-like protein KIF9
KIF9	Q9HAQ2	122	197	1	790	Chain	ID=PRO_0000125442;Note=Kinesin-like protein KIF9
KIF9	Q9HAQ2	505	569	1	790	Chain	ID=PRO_0000125442;Note=Kinesin-like protein KIF9
KIF9	Q9HAQ2	122	197	1	790	Chain	ID=PRO_0000125442;Note=Kinesin-like protein KIF9
KIF9	Q9HAQ2	505	569	1	790	Chain	ID=PRO_0000125442;Note=Kinesin-like protein KIF9
KIF9	Q9HAQ2	122	197	1	790	Chain	ID=PRO_0000125442;Note=Kinesin-like protein KIF9
KIF9	Q9HAQ2	122	197	6	340	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF9	Q9HAQ2	122	197	6	340	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF9	Q9HAQ2	122	197	6	340	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF9	Q9HAQ2	505	569	530	530	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF9	Q9HAQ2	505	569	530	530	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF9	Q9HAQ2	505	569	530	530	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF9	Q9HAQ2	505	569	546	546	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF9	Q9HAQ2	505	569	546	546	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF9	Q9HAQ2	505	569	546	546	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIF9	Q9HAQ2	505	569	505	569	Alternative sequence	ID=VSP_002868;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
KIF9	Q9HAQ2	505	569	505	569	Alternative sequence	ID=VSP_002868;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
KIF9	Q9HAQ2	505	569	505	569	Alternative sequence	ID=VSP_002868;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
KIF9	Q9HAQ2	122	197	115	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	115	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	115	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	133	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	133	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	133	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	167	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	167	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	167	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	174	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	174	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	174	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	188	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	188	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KIF9	Q9HAQ2	122	197	188	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NWN
KCTD2	Q14681	180	212	2	263	Chain	ID=PRO_0000191287;Note=BTB/POZ domain-containing protein KCTD2
KCND3	Q9UK17	487	506	1	655	Chain	ID=PRO_0000054068;Note=Potassium voltage-gated channel subfamily D member 3
KCND3	Q9UK17	487	506	403	655	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCND3	Q9UK17	487	506	472	487	Region	Note=Mediates dendritic targeting;Ontology_term=ECO:0000250;evidence=ECO:0000250
KCND3	Q9UK17	487	506	488	506	Alternative sequence	ID=VSP_008826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10200233,ECO:0000303|PubMed:10729221,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9843794;Dbxref=PMID:10200233,PMID:10729221,PMID:15489334,PMID:9843794
KIF19	Q2TAC6	152	194	1	998	Chain	ID=PRO_0000278245;Note=Kinesin-like protein KIF19
KIF19	Q2TAC6	259	308	1	998	Chain	ID=PRO_0000278245;Note=Kinesin-like protein KIF19
KIF19	Q2TAC6	152	194	11	346	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF19	Q2TAC6	259	308	11	346	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF19	Q2TAC6	152	194	152	193	Alternative sequence	ID=VSP_023207;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIF3A	Q9Y496	619	642	1	699	Chain	ID=PRO_0000125393;Note=Kinesin-like protein KIF3A
KIF3A	Q9Y496	559	601	1	699	Chain	ID=PRO_0000125393;Note=Kinesin-like protein KIF3A
KIF3A	Q9Y496	376	409	1	699	Chain	ID=PRO_0000125393;Note=Kinesin-like protein KIF3A
KIF3A	Q9Y496	559	601	355	590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF3A	Q9Y496	376	409	355	590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF3A	Q9Y496	376	409	409	409	Sequence conflict	Note=R->RDQA;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF3A	Q9Y496	376	409	409	409	Sequence conflict	Note=R->RDQT;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF3A	Q9Y496	376	409	409	409	Sequence conflict	Note=R->RIQI;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF20A	O95235	55	85	2	890	Chain	ID=PRO_0000125460;Note=Kinesin-like protein KIF20A
KIF20A	O95235	506	561	2	890	Chain	ID=PRO_0000125460;Note=Kinesin-like protein KIF20A
KIF20A	O95235	55	85	64	507	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF20A	O95235	506	561	64	507	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF20A	O95235	506	561	528	528	Modified residue	Note=Phosphoserine%3B by PLK1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000269|PubMed:12939256;Dbxref=PMID:18669648,PMID:12939256
KIF20A	O95235	506	561	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
KIF20A	O95235	55	85	65	82	Alternative sequence	ID=VSP_056007;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF20A	O95235	55	85	63	63	Natural variant	ID=VAR_049704;Note=E->K;Dbxref=dbSNP:rs3734116
KIF20A	O95235	506	561	528	528	Mutagenesis	Note=Impairs phosphorylation by PLK1 and recruitment of PLK1 to the spindle. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12939256;Dbxref=PMID:12939256
WWC1	Q8IX03	76	144	1	1113	Chain	ID=PRO_0000242153;Note=Protein KIBRA
WWC1	Q8IX03	314	394	1	1113	Chain	ID=PRO_0000242153;Note=Protein KIBRA
WWC1	Q8IX03	640	666	1	1113	Chain	ID=PRO_0000242153;Note=Protein KIBRA
WWC1	Q8IX03	760	811	1	1113	Chain	ID=PRO_0000242153;Note=Protein KIBRA
WWC1	Q8IX03	972	1050	1	1113	Chain	ID=PRO_0000242153;Note=Protein KIBRA
WWC1	Q8IX03	76	144	53	86	Domain	Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
WWC1	Q8IX03	640	666	655	783	Domain	Note=C2
WWC1	Q8IX03	760	811	655	783	Domain	Note=C2
WWC1	Q8IX03	972	1050	839	1113	Region	Note=Interaction with histone H3
WWC1	Q8IX03	972	1050	953	996	Region	Note=Interaction with PRKCZ
WWC1	Q8IX03	76	144	107	193	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
WWC1	Q8IX03	314	394	293	431	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
WWC1	Q8IX03	972	1050	1001	1032	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
WWC1	Q8IX03	76	144	141	141	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SXA9
WWC1	Q8IX03	972	1050	975	975	Modified residue	Note=Phosphoserine%3B by PKC/PRKCZ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15081397;Dbxref=PMID:15081397
WWC1	Q8IX03	972	1050	978	978	Modified residue	Note=Phosphoserine%3B by PKC/PRKCZ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15081397;Dbxref=PMID:15081397
WWC1	Q8IX03	972	1050	974	974	Alternative sequence	ID=VSP_019448;Note=In isoform 2. S->SPPPQPS;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:10048485,PMID:14702039,PMID:17974005
WWC1	Q8IX03	760	811	811	811	Sequence conflict	Note=T->TVSWDQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
WWC1	Q8IX03	640	666	660	669	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0U
WWC1	Q8IX03	760	811	757	766	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0U
WWC1	Q8IX03	760	811	772	775	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FB4
WWC1	Q8IX03	760	811	777	784	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0U
KIF26A	Q9ULI4	96	245	1	1882	Chain	ID=PRO_0000307299;Note=Kinesin-like protein KIF26A
KIF2C	Q99661	105	146	2	725	Chain	ID=PRO_0000125418;Note=Kinesin-like protein KIF2C
KIF2C	Q99661	146	187	2	725	Chain	ID=PRO_0000125418;Note=Kinesin-like protein KIF2C
KIF2C	Q99661	221	253	2	725	Chain	ID=PRO_0000125418;Note=Kinesin-like protein KIF2C
KIF2C	Q99661	524	561	2	725	Chain	ID=PRO_0000125418;Note=Kinesin-like protein KIF2C
KIF2C	Q99661	524	561	258	588	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF2C	Q99661	105	146	2	254	Region	Note=Globular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF2C	Q99661	146	187	2	254	Region	Note=Globular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF2C	Q99661	221	253	2	254	Region	Note=Globular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF2C	Q99661	221	253	207	238	Region	Note=Negative regulator of microtubule-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
KIF2C	Q99661	105	146	106	106	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIF2C	Q99661	105	146	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70096
KIF2C	Q99661	105	146	111	111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70096
KIF2C	Q99661	105	146	115	115	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIF2C	Q99661	146	187	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
KIF2C	Q99661	146	187	175	175	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIF2C	Q99661	146	187	187	187	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIF2C	Q99661	105	146	109	109	Mutagenesis	Note=Alters interaction with MAPRE1 and association with microtubule growing ends%3B when associated with E-95 and E-111. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19632184;Dbxref=PMID:19632184
KIF2C	Q99661	105	146	111	111	Mutagenesis	Note=Alters interaction with MAPRE1 and association with microtubule growing ends%3B when associated with E-95 and E-109. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19632184;Dbxref=PMID:19632184
KIF2C	Q99661	221	253	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEH
KIF2C	Q99661	221	253	250	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MIO
KIF2C	Q99661	524	561	514	531	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEH
KIF2C	Q99661	524	561	539	541	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEH
KIF2C	Q99661	524	561	543	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEH
KIF2C	Q99661	524	561	549	552	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEH
KIF2C	Q99661	524	561	557	565	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEH
MORN5	Q5VZ52	102	146	1	161	Chain	ID=PRO_0000292840;Note=MORN repeat-containing protein 5
KMT2B	Q9UMN6	819	857	2	2715	Chain	ID=PRO_0000124881;Note=Histone-lysine N-methyltransferase 2B
KMT2B	Q9UMN6	1639	1692	2	2715	Chain	ID=PRO_0000124881;Note=Histone-lysine N-methyltransferase 2B
KMT2B	Q9UMN6	2320	2349	2	2715	Chain	ID=PRO_0000124881;Note=Histone-lysine N-methyltransferase 2B
KMT2B	Q9UMN6	2386	2432	2	2715	Chain	ID=PRO_0000124881;Note=Histone-lysine N-methyltransferase 2B
KMT2B	Q9UMN6	2386	2432	2411	2492	Domain	Note=FYR C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00876
KMT2B	Q9UMN6	1639	1692	1639	1686	Zinc finger	Note=PHD-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01146
KMT2B	Q9UMN6	819	857	821	821	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
KMT2B	Q9UMN6	819	857	844	844	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
KMT2B	Q9UMN6	2320	2349	2348	2348	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KMT2B	Q9UMN6	819	857	583	2715	Alternative sequence	ID=VSP_006669;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMT2B	Q9UMN6	1639	1692	583	2715	Alternative sequence	ID=VSP_006669;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMT2B	Q9UMN6	2320	2349	583	2715	Alternative sequence	ID=VSP_006669;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMT2B	Q9UMN6	2386	2432	583	2715	Alternative sequence	ID=VSP_006669;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMT2B	Q9UMN6	819	857	545	2715	Natural variant	ID=VAR_080233;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	1639	1692	545	2715	Natural variant	ID=VAR_080233;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	2320	2349	545	2715	Natural variant	ID=VAR_080233;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	2386	2432	545	2715	Natural variant	ID=VAR_080233;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	819	857	564	2715	Natural variant	ID=VAR_080234;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	1639	1692	564	2715	Natural variant	ID=VAR_080234;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	2320	2349	564	2715	Natural variant	ID=VAR_080234;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	2386	2432	564	2715	Natural variant	ID=VAR_080234;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	819	857	810	2715	Natural variant	ID=VAR_080235;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	1639	1692	810	2715	Natural variant	ID=VAR_080235;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	2320	2349	810	2715	Natural variant	ID=VAR_080235;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	2386	2432	810	2715	Natural variant	ID=VAR_080235;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839873;Dbxref=PMID:27839873
KMT2B	Q9UMN6	1639	1692	1515	2715	Natural variant	ID=VAR_080236;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	2320	2349	1515	2715	Natural variant	ID=VAR_080236;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	2386	2432	1515	2715	Natural variant	ID=VAR_080236;Note=In DYT28. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	1639	1692	1652	1652	Natural variant	ID=VAR_080237;Note=In DYT28%3B unknown pathological significance. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	1639	1692	1662	1662	Natural variant	ID=VAR_080238;Note=In DYT28%3B unknown pathological significance. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27992417;Dbxref=PMID:27992417
KMT2B	Q9UMN6	2386	2432	2408	2408	Natural variant	ID=VAR_052655;Note=K->N;Dbxref=dbSNP:rs36062432
KMT2B	Q9UMN6	819	857	834	834	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
KNG1	P01042	65	102	19	644	Chain	ID=PRO_0000006685;Note=Kininogen-1
KNG1	P01042	188	224	19	644	Chain	ID=PRO_0000006685;Note=Kininogen-1
KNG1	P01042	346	375	19	644	Chain	ID=PRO_0000006685;Note=Kininogen-1
KNG1	P01042	65	102	19	380	Chain	ID=PRO_0000006686;Note=Kininogen-1 heavy chain
KNG1	P01042	188	224	19	380	Chain	ID=PRO_0000006686;Note=Kininogen-1 heavy chain
KNG1	P01042	346	375	19	380	Chain	ID=PRO_0000006686;Note=Kininogen-1 heavy chain
KNG1	P01042	65	102	28	132	Domain	Note=Cystatin kininogen-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00979
KNG1	P01042	188	224	151	254	Domain	Note=Cystatin kininogen-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00979
KNG1	P01042	346	375	273	376	Domain	Note=Cystatin kininogen-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00979
KNG1	P01042	188	224	205	205	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:3484703;Dbxref=PMID:16335952,PMID:19139490,PMID:19159218,PMID:3484703
KNG1	P01042	65	102	28	614	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00979,ECO:0000269|Ref.16
KNG1	P01042	188	224	28	614	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00979,ECO:0000269|Ref.16
KNG1	P01042	346	375	28	614	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00979,ECO:0000269|Ref.16
KNG1	P01042	65	102	83	94	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00979,ECO:0000269|Ref.16
KNG1	P01042	188	224	206	218	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00979,ECO:0000269|Ref.16
KNG1	P01042	346	375	351	370	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00979,ECO:0000269|Ref.16
KNG1	P01042	188	224	189	224	Alternative sequence	ID=VSP_047307;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KNG1	P01042	188	224	197	197	Natural variant	ID=VAR_028937;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2304456,PMID:15489334
KNG1	P01042	188	224	212	212	Natural variant	ID=VAR_019279;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs5030024
KNOP1	Q1ED39	306	329	1	458	Chain	ID=PRO_0000321938;Note=Lysine-rich nucleolar protein 1
KNOP1	Q1ED39	306	329	306	458	Region	Note=Interaction with ZNF106;Ontology_term=ECO:0000250;evidence=ECO:0000250
KNOP1	Q1ED39	306	329	308	308	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KNOP1	Q1ED39	306	329	310	310	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
KNOP1	Q1ED39	306	329	319	319	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MAP2K4	P45985	131	171	2	399	Chain	ID=PRO_0000086381;Note=Dual specificity mitogen-activated protein kinase kinase 4
MAP2K4	P45985	171	211	2	399	Chain	ID=PRO_0000086381;Note=Dual specificity mitogen-activated protein kinase kinase 4
MAP2K4	P45985	131	171	102	367	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K4	P45985	171	211	102	367	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K4	P45985	131	171	131	131	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K4	P45985	131	171	142	142	Natural variant	ID=VAR_040818;Note=In a lung squamous cell carcinoma sample%3B somatic mutation. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MAP2K4	P45985	131	171	154	154	Natural variant	ID=VAR_040819;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MAP2K4	P45985	171	211	179	179	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2K4	P45985	131	171	127	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	131	171	139	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	131	171	164	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	131	171	171	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	171	211	171	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	171	211	182	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	171	211	185	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K4	P45985	171	211	202	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN
MAP2K6	P52564	122	161	1	334	Chain	ID=PRO_0000086386;Note=Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6	P52564	122	161	53	314	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K6	P52564	122	161	125	125	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2K6	P52564	122	161	125	125	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2K6	P52564	122	161	122	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FME
MAP2K6	P52564	122	161	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FME
MAP2K6	P52564	122	161	136	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FME
MAP2K6	P52564	122	161	152	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FME
KATNB1	Q9BVA0	144	172	1	655	Chain	ID=PRO_0000051049;Note=Katanin p80 WD40 repeat-containing subunit B1
KATNB1	Q9BVA0	144	172	145	184	Repeat	Note=WD 4
KATNB1	Q9BVA0	144	172	1	300	Region	Note=Interaction with centrosomes
KATNB1	Q9BVA0	144	172	1	284	Region	Note=Interaction with dynein;Ontology_term=ECO:0000250;evidence=ECO:0000250
LAMA2	P24043	2849	2901	23	3122	Chain	ID=PRO_0000017056;Note=Laminin subunit alpha-2
LAMA2	P24043	2849	2901	2763	2934	Domain	Note=Laminin G-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
LAMA2	P24043	2849	2901	2868	2868	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMA2	P24043	2849	2901	2893	2893	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMA2	P24043	2849	2901	2889	2889	Natural variant	ID=VAR_076560;Note=In MDC1A. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234031;Dbxref=dbSNP:rs886039896,PMID:27234031
LAMB1	P07942	1396	1464	22	1786	Chain	ID=PRO_0000017065;Note=Laminin subunit beta-1
LAMB1	P07942	951	1026	22	1786	Chain	ID=PRO_0000017065;Note=Laminin subunit beta-1
LAMB1	P07942	771	819	22	1786	Chain	ID=PRO_0000017065;Note=Laminin subunit beta-1
LAMB1	P07942	566	619	22	1786	Chain	ID=PRO_0000017065;Note=Laminin subunit beta-1
LAMB1	P07942	333	396	22	1786	Chain	ID=PRO_0000017065;Note=Laminin subunit beta-1
LAMB1	P07942	141	204	22	1786	Chain	ID=PRO_0000017065;Note=Laminin subunit beta-1
LAMB1	P07942	141	204	31	270	Domain	Note=Laminin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00466
LAMB1	P07942	333	396	271	334	Domain	Note=Laminin EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	333	396	335	397	Domain	Note=Laminin EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	566	619	549	767	Domain	Note=Laminin IV type B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00462
LAMB1	P07942	771	819	773	820	Domain	Note=Laminin EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	917	975	Domain	Note=Laminin EGF-like 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	976	1027	Domain	Note=Laminin EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	1396	1464	1179	1397	Region	Note=Domain II
LAMB1	P07942	1396	1464	1398	1430	Region	Note=Domain alpha
LAMB1	P07942	1396	1464	1431	1786	Region	Note=Domain I
LAMB1	P07942	1396	1464	1442	1781	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB1	P07942	333	396	356	356	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB1	P07942	333	396	335	344	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	333	396	337	362	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	333	396	365	374	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	333	396	377	395	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	771	819	773	785	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	771	819	775	792	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	771	819	794	803	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	771	819	806	818	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	946	955	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	958	973	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	976	990	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	978	997	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	1000	1009	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	951	1026	1012	1025	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
LAMB1	P07942	333	396	379	379	Natural variant	ID=VAR_061349;Note=P->S;Dbxref=dbSNP:rs28750165
LAMB1	P07942	951	1026	1022	1022	Natural variant	ID=VAR_014699;Note=Q->R;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:21269460,ECO:0000269|PubMed:1975589,ECO:0000269|PubMed:3611077;Dbxref=dbSNP:rs20556,PMID:21269460,PMID:1975589,PMID:3611077
LATS2	Q9NRM7	827	888	1	1088	Chain	ID=PRO_0000086234;Note=Serine/threonine-protein kinase LATS2
LATS2	Q9NRM7	827	888	668	973	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LATS2	Q9NRM7	827	888	872	872	Mutagenesis	Note=Loss of tumor suppressor activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12853976;Dbxref=PMID:12853976
LATS2	Q9NRM7	827	888	868	868	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAT	O43561	214	236	1	262	Chain	ID=PRO_0000083325;Note=Linker for activation of T-cells family member 1
LAT	O43561	214	236	28	262	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAT	O43561	214	236	220	223	Region	Note=Interaction with GRB2%2C GRAP2 and PIK3R1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10811803;Dbxref=PMID:10811803
LAT	O43561	214	236	220	220	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAT	O43561	214	236	224	224	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18088087;Dbxref=PMID:18088087
LAT	O43561	214	236	220	220	Mutagenesis	Note=Abolishes interaction with GRB2 and PIK3R1%3B when associated with F-200. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9489702;Dbxref=PMID:9489702
LNPEP	Q9UIQ6	908	954	1	1025	Chain	ID=PRO_0000095114;Note=Leucyl-cystinyl aminopeptidase
LNPEP	Q9UIQ6	908	954	155	1025	Chain	ID=PRO_0000292264;Note=Leucyl-cystinyl aminopeptidase%2C pregnancy serum form
LNPEP	Q9UIQ6	908	954	132	1025	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LNPEP	Q9UIQ6	908	954	913	913	Natural variant	ID=VAR_051568;Note=S->T;Dbxref=dbSNP:rs17087233
LNPEP	Q9UIQ6	908	954	944	944	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
LNPEP	Q9UIQ6	908	954	903	915	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJ6
LNPEP	Q9UIQ6	908	954	917	919	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ6
LNPEP	Q9UIQ6	908	954	921	923	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJ6
LNPEP	Q9UIQ6	908	954	924	933	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJ6
LNPEP	Q9UIQ6	908	954	935	947	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJ6
LNPEP	Q9UIQ6	908	954	949	955	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJ6
LBR	Q14739	494	521	1	615	Chain	ID=PRO_0000207510;Note=Lamin-B receptor
LBR	Q14739	396	438	1	615	Chain	ID=PRO_0000207510;Note=Lamin-B receptor
LBR	Q14739	494	521	1	615	Chain	ID=PRO_0000207510;Note=Lamin-B receptor
LBR	Q14739	396	438	1	615	Chain	ID=PRO_0000207510;Note=Lamin-B receptor
LBR	Q14739	396	438	386	406	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LBR	Q14739	396	438	386	406	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LBR	Q14739	494	521	481	501	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LBR	Q14739	494	521	481	501	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KHDRBS3	O75525	69	108	1	346	Chain	ID=PRO_0000232522;Note=KH domain-containing%2C RNA-binding%2C signal transduction-associated protein 3
KHDRBS3	O75525	69	108	61	127	Domain	Note=KH
KHDRBS3	O75525	69	108	1	160	Region	Note=Involved in homodimerization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26758068;Dbxref=PMID:26758068
KHDRBS3	O75525	69	108	72	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EL3
KHDRBS3	O75525	69	108	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ELT
KHDRBS3	O75525	69	108	83	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EL3
KHDRBS3	O75525	69	108	93	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EL3
KHDRBS3	O75525	69	108	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ELS
KHDRBS3	O75525	69	108	106	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EL3
KLC4	Q9NSK0	86	163	2	619	Chain	ID=PRO_0000215097;Note=Kinesin light chain 4
KLC4	Q9NSK0	293	327	2	619	Chain	ID=PRO_0000215097;Note=Kinesin light chain 4
KLC4	Q9NSK0	86	163	2	619	Chain	ID=PRO_0000215097;Note=Kinesin light chain 4
KLC4	Q9NSK0	293	327	2	619	Chain	ID=PRO_0000215097;Note=Kinesin light chain 4
KLC4	Q9NSK0	86	163	2	619	Chain	ID=PRO_0000215097;Note=Kinesin light chain 4
KLC4	Q9NSK0	293	327	2	619	Chain	ID=PRO_0000215097;Note=Kinesin light chain 4
KLC4	Q9NSK0	86	163	55	88	Repeat	Note=TPR 1
KLC4	Q9NSK0	86	163	55	88	Repeat	Note=TPR 1
KLC4	Q9NSK0	86	163	55	88	Repeat	Note=TPR 1
KLC4	Q9NSK0	293	327	295	328	Repeat	Note=TPR 4
KLC4	Q9NSK0	293	327	295	328	Repeat	Note=TPR 4
KLC4	Q9NSK0	293	327	295	328	Repeat	Note=TPR 4
KLC4	Q9NSK0	86	163	32	150	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KLC4	Q9NSK0	86	163	32	150	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KLC4	Q9NSK0	86	163	32	150	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KLC4	Q9NSK0	86	163	87	163	Alternative sequence	ID=VSP_057231;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	87	163	Alternative sequence	ID=VSP_057231;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	87	163	Alternative sequence	ID=VSP_057231;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	87	131	Alternative sequence	ID=VSP_037875;Note=In isoform 2. VMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQ->NLELRGCAHLGDAGSSQPPEHSGVGETEAAGSGAAAMPGEPVAAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	87	131	Alternative sequence	ID=VSP_037875;Note=In isoform 2. VMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQ->NLELRGCAHLGDAGSSQPPEHSGVGETEAAGSGAAAMPGEPVAAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	87	131	Alternative sequence	ID=VSP_037875;Note=In isoform 2. VMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQ->NLELRGCAHLGDAGSSQPPEHSGVGETEAAGSGAAAMPGEPVAAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	132	619	Alternative sequence	ID=VSP_037876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	293	327	132	619	Alternative sequence	ID=VSP_037876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	132	619	Alternative sequence	ID=VSP_037876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	293	327	132	619	Alternative sequence	ID=VSP_037876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	86	163	132	619	Alternative sequence	ID=VSP_037876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	293	327	132	619	Alternative sequence	ID=VSP_037876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC4	Q9NSK0	293	327	295	315	Alternative sequence	ID=VSP_043324;Note=In isoform 4. AATLNNLAVLYGKRGKYKEAE->SIPCPPHPTPRTPHHCCFGLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLC4	Q9NSK0	293	327	295	315	Alternative sequence	ID=VSP_043324;Note=In isoform 4. AATLNNLAVLYGKRGKYKEAE->SIPCPPHPTPRTPHHCCFGLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLC4	Q9NSK0	293	327	295	315	Alternative sequence	ID=VSP_043324;Note=In isoform 4. AATLNNLAVLYGKRGKYKEAE->SIPCPPHPTPRTPHHCCFGLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLC4	Q9NSK0	293	327	316	619	Alternative sequence	ID=VSP_043325;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLC4	Q9NSK0	293	327	316	619	Alternative sequence	ID=VSP_043325;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLC4	Q9NSK0	293	327	316	619	Alternative sequence	ID=VSP_043325;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KLHL17	Q6TDP4	396	451	1	642	Chain	ID=PRO_0000119119;Note=Kelch-like protein 17
KLHL17	Q6TDP4	396	451	390	436	Repeat	Note=Kelch 2
KLHL17	Q6TDP4	396	451	438	483	Repeat	Note=Kelch 3
KLHL17	Q6TDP4	396	451	289	641	Region	Note=Interaction with F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250
MON1A	Q86VX9	139	301	1	652	Chain	ID=PRO_0000285761;Note=Vacuolar fusion protein MON1 homolog A
MON1A	Q86VX9	139	301	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6PDG8
MON1A	Q86VX9	139	301	158	158	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MON1A	Q86VX9	139	301	188	188	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MON1A	Q86VX9	139	301	140	301	Alternative sequence	ID=VSP_059431;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SLC16A9	Q7RTY1	145	450	1	509	Chain	ID=PRO_0000289332;Note=Monocarboxylate transporter 9
SLC16A9	Q7RTY1	113	145	1	509	Chain	ID=PRO_0000289332;Note=Monocarboxylate transporter 9
SLC16A9	Q7RTY1	65	113	1	509	Chain	ID=PRO_0000289332;Note=Monocarboxylate transporter 9
SLC16A9	Q7RTY1	145	450	1	509	Chain	ID=PRO_0000289332;Note=Monocarboxylate transporter 9
SLC16A9	Q7RTY1	113	145	1	509	Chain	ID=PRO_0000289332;Note=Monocarboxylate transporter 9
SLC16A9	Q7RTY1	65	113	1	509	Chain	ID=PRO_0000289332;Note=Monocarboxylate transporter 9
SLC16A9	Q7RTY1	65	113	53	73	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	65	113	53	73	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	65	113	80	100	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	65	113	80	100	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	113	145	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	65	113	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	113	145	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	65	113	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	113	145	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	113	145	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	164	184	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	164	184	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	305	325	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	305	325	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	372	392	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	372	392	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	398	418	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	398	418	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	433	453	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	433	453	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A9	Q7RTY1	145	450	203	203	Natural variant	ID=VAR_062149;Note=A->V;Dbxref=dbSNP:rs56370926
SLC16A9	Q7RTY1	145	450	203	203	Natural variant	ID=VAR_062149;Note=A->V;Dbxref=dbSNP:rs56370926
SLC16A9	Q7RTY1	145	450	258	258	Natural variant	ID=VAR_032619;Note=T->K;Dbxref=dbSNP:rs2242206
SLC16A9	Q7RTY1	145	450	258	258	Natural variant	ID=VAR_032619;Note=T->K;Dbxref=dbSNP:rs2242206
KNTC1	P50748	148	174	1	2209	Chain	ID=PRO_0000084312;Note=Kinetochore-associated protein 1
KNTC1	P50748	186	223	1	2209	Chain	ID=PRO_0000084312;Note=Kinetochore-associated protein 1
KNTC1	P50748	466	496	1	2209	Chain	ID=PRO_0000084312;Note=Kinetochore-associated protein 1
KNTC1	P50748	1224	1243	1	2209	Chain	ID=PRO_0000084312;Note=Kinetochore-associated protein 1
KNTC1	P50748	1521	1551	1	2209	Chain	ID=PRO_0000084312;Note=Kinetochore-associated protein 1
KNTC1	P50748	1991	2010	1	2209	Chain	ID=PRO_0000084312;Note=Kinetochore-associated protein 1
KNTC1	P50748	148	174	1	1575	Alternative sequence	ID=VSP_057013;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KNTC1	P50748	186	223	1	1575	Alternative sequence	ID=VSP_057013;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KNTC1	P50748	466	496	1	1575	Alternative sequence	ID=VSP_057013;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KNTC1	P50748	1224	1243	1	1575	Alternative sequence	ID=VSP_057013;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KNTC1	P50748	1521	1551	1	1575	Alternative sequence	ID=VSP_057013;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRKCA	P17252	306	352	2	672	Chain	ID=PRO_0000055679;Note=Protein kinase C alpha type
PRKCA	P17252	352	410	2	672	Chain	ID=PRO_0000055679;Note=Protein kinase C alpha type
PRKCA	P17252	535	571	2	672	Chain	ID=PRO_0000055679;Note=Protein kinase C alpha type
PRKCA	P17252	306	352	339	597	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCA	P17252	352	410	339	597	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCA	P17252	535	571	339	597	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCA	P17252	306	352	345	353	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCA	P17252	352	410	345	353	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCA	P17252	352	410	368	368	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCA	P17252	306	352	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05696
PRKCA	P17252	535	571	568	568	Natural variant	ID=VAR_050558;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:19054851,ECO:0000269|PubMed:2336401,ECO:0000269|Ref.4;Dbxref=dbSNP:rs6504459,PMID:15489334,PMID:19054851,PMID:2336401
PRKCA	P17252	306	352	336	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	306	352	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	306	352	352	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	352	410	352	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	352	410	364	371	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	352	410	372	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	352	410	381	392	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	352	410	403	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	352	410	410	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	535	571	543	552	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKCA	P17252	535	571	563	572	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4
PRKD3	O94806	682	715	1	890	Chain	ID=PRO_0000055717;Note=Serine/threonine-protein kinase D3
PRKD3	O94806	628	682	1	890	Chain	ID=PRO_0000055717;Note=Serine/threonine-protein kinase D3
PRKD3	O94806	682	715	1	890	Chain	ID=PRO_0000055717;Note=Serine/threonine-protein kinase D3
PRKD3	O94806	628	682	1	890	Chain	ID=PRO_0000055717;Note=Serine/threonine-protein kinase D3
PRKD3	O94806	682	715	576	832	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKD3	O94806	628	682	576	832	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKD3	O94806	682	715	576	832	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKD3	O94806	628	682	576	832	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKD3	O94806	682	715	699	699	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
PRKD3	O94806	682	715	699	699	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
PRKD3	O94806	682	715	612	890	Alternative sequence	ID=VSP_029406;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRKD3	O94806	628	682	612	890	Alternative sequence	ID=VSP_029406;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRKD3	O94806	682	715	612	890	Alternative sequence	ID=VSP_029406;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRKD3	O94806	628	682	612	890	Alternative sequence	ID=VSP_029406;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRKCE	Q02156	577	640	1	737	Chain	ID=PRO_0000055697;Note=Protein kinase C epsilon type
PRKCE	Q02156	577	640	408	668	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA6	Q9UK32	657	704	1	745	Chain	ID=PRO_0000086209;Note=Ribosomal protein S6 kinase alpha-6
RPS6KA6	Q9UK32	538	592	1	745	Chain	ID=PRO_0000086209;Note=Ribosomal protein S6 kinase alpha-6
RPS6KA6	Q9UK32	657	704	426	683	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA6	Q9UK32	538	592	426	683	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA6	Q9UK32	538	592	543	543	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPS6KA6	Q9UK32	538	592	581	581	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15632195;Dbxref=PMID:15632195
RPS6KA6	Q9UK32	657	704	692	692	Natural variant	ID=VAR_030670;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs6616890,PMID:17344846
RPS6KA6	Q9UK32	538	592	581	581	Mutagenesis	Note=No effect on activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15632195;Dbxref=PMID:15632195
MPI	P34949	162	223	2	423	Chain	ID=PRO_0000194235;Note=Mannose-6-phosphate isomerase
MPI	P34949	162	223	163	224	Alternative sequence	ID=VSP_013357;Note=In isoform 2. KVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQA->T;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MPI	P34949	162	223	219	219	Natural variant	ID=VAR_012340;Note=In CDG1B. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11350186,ECO:0000269|PubMed:9525984;Dbxref=dbSNP:rs104894489,PMID:11350186,PMID:9525984
IGF1R	P08069	1062	1099	741	1367	Chain	ID=PRO_0000016682;Note=Insulin-like growth factor 1 receptor beta chain
IGF1R	P08069	1062	1099	960	1367	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF1R	P08069	1062	1099	999	1274	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IGF1R	P08069	1062	1099	1065	1069	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P4O
IGF1R	P08069	1062	1099	1071	1074	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P4O
IGF1R	P08069	1062	1099	1076	1080	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P4O
IGF1R	P08069	1062	1099	1087	1100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P4O
IKBKB	O14920	159	189	1	756	Chain	ID=PRO_0000086013;Note=Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB	O14920	231	266	1	756	Chain	ID=PRO_0000086013;Note=Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB	O14920	159	189	15	300	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IKBKB	O14920	231	266	15	300	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IKBKB	O14920	159	189	177	177	Modified residue	Note=Phosphoserine%3B by TBK1 and PKC/PRKCZ;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10022904,ECO:0000269|PubMed:10195894,ECO:0000269|PubMed:10783893;Dbxref=PMID:10022904,PMID:10195894,PMID:10783893
IKBKB	O14920	159	189	179	179	Modified residue	Note=S-nitrosocysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15184672;Dbxref=PMID:15184672
IKBKB	O14920	159	189	180	180	Modified residue	Note=O-acetylthreonine%3B by Yersinia yopJ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17116858;Dbxref=PMID:17116858
IKBKB	O14920	159	189	181	181	Modified residue	Note=Phosphoserine%3B by TBK1%2C PKC/PRKCZ and PDPK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10022904,ECO:0000269|PubMed:10195894,ECO:0000269|PubMed:10783893,ECO:0000269|PubMed:16207722;Dbxref=PMID:10022904,PMID:10195894,PMID:10783893,PMID:16207722
IKBKB	O14920	159	189	163	163	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16267042;Dbxref=PMID:16267042
IKBKB	O14920	231	266	231	256	Alternative sequence	ID=VSP_041826;Note=In isoform 3. WHSKVRQKSEVDIVVSEDLNGTVKFS->CVRMWPGTVAHSCNPSTLGGRGRWIS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IKBKB	O14920	231	266	257	756	Alternative sequence	ID=VSP_041827;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IKBKB	O14920	159	189	163	163	Mutagenesis	Note=Monoubiquitinated%3B when associated with E-177 and E-181. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19675099;Dbxref=PMID:19675099
IKBKB	O14920	159	189	177	181	Mutagenesis	Note=COmplete loss of TBK1-mediated phosphorylation. SLCTS->ALCTA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10783893;Dbxref=PMID:10783893
IKBKB	O14920	159	189	177	177	Mutagenesis	Note=Decrease of activity. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19675099,ECO:0000269|PubMed:9346484;Dbxref=PMID:19675099,PMID:9346484
IKBKB	O14920	159	189	177	177	Mutagenesis	Note=Full activation. Interaction with TRIM21 is enhanced%3B when associated with E-181. Monoubiquitinated%3B when associated with R-163 and E-181. Strongly promoted NF-kappa-B gene expression%3B when associated with E-181. S->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19675099,ECO:0000269|PubMed:9346484;Dbxref=PMID:19675099,PMID:9346484
IKBKB	O14920	159	189	181	181	Mutagenesis	Note=Decrease of activity. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19675099,ECO:0000269|PubMed:9346484;Dbxref=PMID:19675099,PMID:9346484
IKBKB	O14920	159	189	181	181	Mutagenesis	Note=Full activation. Interaction with TRIM21 is enhanced%3B when associated with E-177. Monoubiquitinated%3B when associated with R-163 and E-177. Strongly promoted NF-kappa-B gene expression%3B when associated with E-177. S->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19675099,ECO:0000269|PubMed:9346484;Dbxref=PMID:19675099,PMID:9346484
IKBKB	O14920	231	266	259	259	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKBKB	O14920	231	266	259	259	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKBKB	O14920	159	189	157	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KIK
IKBKB	O14920	159	189	182	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KIK
IKBKB	O14920	159	189	186	188	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KIK
IKBKB	O14920	231	266	228	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KIK
IKBKB	O14920	231	266	244	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KIK
IKBKB	O14920	231	266	253	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KIK
IL20	Q9NYY1	126	151	25	176	Chain	ID=PRO_0000015381;Note=Interleukin-20
IL20	Q9NYY1	126	151	25	176	Chain	ID=PRO_0000015381;Note=Interleukin-20
IL20	Q9NYY1	126	151	33	126	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22802649;Dbxref=PMID:22802649
IL20	Q9NYY1	126	151	33	126	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22802649;Dbxref=PMID:22802649
IL20	Q9NYY1	126	151	80	132	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22802649;Dbxref=PMID:22802649
IL20	Q9NYY1	126	151	80	132	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22802649;Dbxref=PMID:22802649
IL20	Q9NYY1	126	151	81	134	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22802649;Dbxref=PMID:22802649
IL20	Q9NYY1	126	151	81	134	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22802649;Dbxref=PMID:22802649
IL20	Q9NYY1	126	151	127	151	Alternative sequence	ID=VSP_054904;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16511554;Dbxref=PMID:16511554
IL20	Q9NYY1	126	151	127	151	Alternative sequence	ID=VSP_054904;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16511554;Dbxref=PMID:16511554
IL20	Q9NYY1	126	151	126	126	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL20	Q9NYY1	126	151	126	126	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL20	Q9NYY1	126	151	103	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DOH
IL20	Q9NYY1	126	151	103	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DOH
IL20	Q9NYY1	126	151	136	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DOH
IL20	Q9NYY1	126	151	136	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DOH
IQCC	Q4KMZ1	14	62	1	466	Chain	ID=PRO_0000282545;Note=IQ domain-containing protein C
IQCC	Q4KMZ1	14	62	6	35	Domain	Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQCC	Q4KMZ1	14	62	14	14	Alternative sequence	ID=VSP_046123;Note=In isoform 3. Q->QVRGRARGSQDFSFREIMGSRTWTSQRDATTFSPLTARQPLEIPAVPNRAEESWDPRTPCPARPHSHHTLAPDQGNGKSLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IQCK	Q8N0W5	176	201	1	287	Chain	ID=PRO_0000282574;Note=IQ domain-containing protein K
IQCK	Q8N0W5	176	201	159	209	Alternative sequence	ID=VSP_024204;Note=In isoform 3. RKRTKFIACDFLTEWLYNQNPKRAGEPFTEFFSIPFVEERLKQHPRPPIPL->VSCLAGFLYFEILNHSLLSDDSSLSWYHQVVLQMTPSGGKACVWGHLPSSSHTI;Ontology_term=ECO:0000305;evidence=ECO:0000305
IQCK	Q8N0W5	176	201	159	189	Alternative sequence	ID=VSP_024205;Note=In isoform 2. RKRTKFIACDFLTEWLYNQNPKRAGEPFTEF->PTAANPTLAPADRRGSSPLHSILLESLCGSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
IQCK	Q8N0W5	176	201	190	287	Alternative sequence	ID=VSP_024206;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
IRAK1	P51617	643	693	1	712	Chain	ID=PRO_0000086030;Note=Interleukin-1 receptor-associated kinase 1
IRAK1	P51617	434	513	1	712	Chain	ID=PRO_0000086030;Note=Interleukin-1 receptor-associated kinase 1
IRAK1	P51617	412	434	1	712	Chain	ID=PRO_0000086030;Note=Interleukin-1 receptor-associated kinase 1
IRAK1	P51617	180	243	1	712	Chain	ID=PRO_0000086030;Note=Interleukin-1 receptor-associated kinase 1
IRAK1	P51617	101	145	1	712	Chain	ID=PRO_0000086030;Note=Interleukin-1 receptor-associated kinase 1
IRAK1	P51617	101	145	27	106	Domain	Note=Death
IRAK1	P51617	434	513	212	521	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IRAK1	P51617	412	434	212	521	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IRAK1	P51617	180	243	212	521	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IRAK1	P51617	180	243	218	226	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
IRAK1	P51617	180	243	110	211	Region	Note=ProST region
IRAK1	P51617	101	145	110	211	Region	Note=ProST region
IRAK1	P51617	643	693	649	655	Compositional bias	Note=Poly-Ser
IRAK1	P51617	643	693	688	691	Compositional bias	Note=Poly-Ser
IRAK1	P51617	180	243	239	239	Binding site	Note=ATP
IRAK1	P51617	101	145	131	131	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
IRAK1	P51617	180	243	209	209	Modified residue	Note=Phosphothreonine%3B by IRAK4;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14625308;Dbxref=PMID:14625308
IRAK1	P51617	101	145	134	134	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18347055;Dbxref=PMID:18347055
IRAK1	P51617	180	243	180	180	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18347055;Dbxref=PMID:18347055
IRAK1	P51617	434	513	435	513	Alternative sequence	ID=VSP_041950;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16024789;Dbxref=PMID:15489334,PMID:16024789
IRAK1	P51617	434	513	478	492	Alternative sequence	ID=VSP_011850;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IRAK1	P51617	434	513	513	542	Alternative sequence	ID=VSP_011851;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11397809,ECO:0000303|PubMed:15489334;Dbxref=PMID:11397809,PMID:15489334
IRAK1	P51617	180	243	194	194	Natural variant	ID=VAR_051629;Note=R->H;Dbxref=dbSNP:rs11465830
IRAK1	P51617	180	243	196	196	Natural variant	ID=VAR_051630;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8599092;Dbxref=dbSNP:rs1059702,PMID:8599092
IRAK1	P51617	180	243	203	203	Natural variant	ID=VAR_051631;Note=C->S;Dbxref=dbSNP:rs10127175
IRAK1	P51617	412	434	412	412	Natural variant	ID=VAR_040574;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
IRAK1	P51617	412	434	421	421	Natural variant	ID=VAR_040575;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
IRAK1	P51617	643	693	690	690	Natural variant	ID=VAR_040580;Note=In a lung adenocarcinoma sample%3B somatic mutation. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
IRAK1	P51617	180	243	209	209	Mutagenesis	Note=Completely abolishes auto-phosphorylation in the kinase domain. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14625308;Dbxref=PMID:14625308
IRAK1	P51617	180	243	239	239	Mutagenesis	Note=Loss of kinase activity. K->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15084582;Dbxref=PMID:15084582
IRAK1	P51617	180	243	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	180	243	202	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	180	243	210	212	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	180	243	217	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	180	243	222	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	180	243	234	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	412	434	403	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	412	434	423	427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	412	434	430	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	434	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	412	434	434	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	437	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	464	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	467	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	487	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	505	507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRAK1	P51617	434	513	511	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BFN
IRF7	Q92985	226	255	1	503	Chain	ID=PRO_0000154562;Note=Interferon regulatory factor 7
IRF7	Q92985	120	149	1	503	Chain	ID=PRO_0000154562;Note=Interferon regulatory factor 7
IRF7	Q92985	120	149	11	126	DNA binding	Note=IRF tryptophan pentad repeat;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00840
IRF7	Q92985	226	255	165	503	Alternative sequence	ID=VSP_002759;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9315633;Dbxref=PMID:9315633
IRF7	Q92985	226	255	228	256	Alternative sequence	ID=VSP_002760;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9315633;Dbxref=PMID:9315633
IRF7	Q92985	120	149	119	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O61
CHCHD6	Q9BRQ6	137	165	2	235	Chain	ID=PRO_0000129169;Note=MICOS complex subunit MIC25
CHCHD6	Q9BRQ6	137	165	129	176	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ISG20	Q96AZ6	76	143	1	181	Chain	ID=PRO_0000084243;Note=Interferon-stimulated gene 20 kDa protein
ISG20	Q96AZ6	76	143	1	181	Chain	ID=PRO_0000084243;Note=Interferon-stimulated gene 20 kDa protein
ISG20	Q96AZ6	76	143	90	90	Metal binding	Note=Manganese 2
ISG20	Q96AZ6	76	143	90	90	Metal binding	Note=Manganese 2
ISG20	Q96AZ6	76	143	93	93	Metal binding	Note=Manganese 2
ISG20	Q96AZ6	76	143	93	93	Metal binding	Note=Manganese 2
ISG20	Q96AZ6	76	143	77	86	Alternative sequence	ID=VSP_012429;Note=In isoform 2. ILQLLKGKLV->VPFPSSPTAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ISG20	Q96AZ6	76	143	77	86	Alternative sequence	ID=VSP_012429;Note=In isoform 2. ILQLLKGKLV->VPFPSSPTAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ISG20	Q96AZ6	76	143	87	181	Alternative sequence	ID=VSP_012430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ISG20	Q96AZ6	76	143	87	181	Alternative sequence	ID=VSP_012430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ISG20	Q96AZ6	76	143	70	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	70	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	84	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	84	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	91	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	91	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	106	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	106	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	110	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	110	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	114	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	114	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	130	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ISG20	Q96AZ6	76	143	130	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WLJ
ITIH4	Q14624	726	765	689	930	Chain	ID=PRO_0000016543;Note=35 kDa inter-alpha-trypsin inhibitor heavy chain H4
ITIH4	Q14624	726	765	747	925	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH4	Q14624	726	765	727	765	Alternative sequence	ID=VSP_044764;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16271702;Dbxref=PMID:16271702
ITIH4	Q14624	726	765	727	727	Alternative sequence	ID=VSP_002762;Note=In isoform 2. A->ACPSCSRSRAPAVPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
ITGB1BP2	Q9UKP3	38	57	1	347	Chain	ID=PRO_0000084267;Note=Integrin beta-1-binding protein 2
ITGB1BP2	Q9UKP3	251	272	1	347	Chain	ID=PRO_0000084267;Note=Integrin beta-1-binding protein 2
ITGB1BP2	Q9UKP3	38	57	5	64	Domain	Note=CHORD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00734
ITGB1BP2	Q9UKP3	251	272	215	304	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
ITGB1BP2	Q9UKP3	38	57	5	59	Compositional bias	Note=Cys-rich
ITGB1BP2	Q9UKP3	38	57	42	42	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00734
ITGB1BP2	Q9UKP3	38	57	43	43	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00734
JAK2	O60674	1059	1097	1	1132	Chain	ID=PRO_0000088112;Note=Tyrosine-protein kinase JAK2
JAK2	O60674	1059	1097	849	1124	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
JAK2	O60674	1059	1097	1063	1063	Natural variant	ID=VAR_041721;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs41316003,PMID:17344846
JAK2	O60674	1059	1097	1057	1065	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UGC
JAK2	O60674	1059	1097	1069	1071	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HEZ
JAK2	O60674	1059	1097	1072	1083	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UGC
JAK2	O60674	1059	1097	1084	1086	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HEZ
JAK2	O60674	1059	1097	1096	1105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UGC
F11R	Q9Y624	80	129	28	299	Chain	ID=PRO_0000015066;Note=Junctional adhesion molecule A
F11R	Q9Y624	80	129	28	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
F11R	Q9Y624	80	129	28	125	Domain	Note=Ig-like V-type 1
F11R	Q9Y624	80	129	50	109	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12697893;Dbxref=PMID:12697893
F11R	Q9Y624	80	129	81	129	Alternative sequence	ID=VSP_056218;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
F11R	Q9Y624	80	129	81	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NBQ
F11R	Q9Y624	80	129	88	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NBQ
F11R	Q9Y624	80	129	93	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NBQ
F11R	Q9Y624	80	129	101	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ODB
F11R	Q9Y624	80	129	105	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NBQ
F11R	Q9Y624	80	129	123	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NBQ
F11R	Q9Y624	80	129	128	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NBQ
KLHL30	Q0D2K2	302	331	1	578	Chain	ID=PRO_0000274594;Note=Kelch-like protein 30
KLHL30	Q0D2K2	302	331	270	326	Repeat	Note=Kelch 1
KLHL30	Q0D2K2	302	331	327	377	Repeat	Note=Kelch 2
KLHDC3	Q9BQ90	51	110	1	382	Chain	ID=PRO_0000228995;Note=Kelch domain-containing protein 3
KLHDC3	Q9BQ90	149	173	1	382	Chain	ID=PRO_0000228995;Note=Kelch domain-containing protein 3
KLHDC3	Q9BQ90	51	110	25	77	Repeat	Note=Kelch 1
KLHDC3	Q9BQ90	51	110	88	138	Repeat	Note=Kelch 2
KLHDC3	Q9BQ90	149	173	139	189	Repeat	Note=Kelch 3
KMT2D	O14686	4510	4557	1	5537	Chain	ID=PRO_0000124878;Note=Histone-lysine N-methyltransferase 2D
KMT2D	O14686	1694	1729	1	5537	Chain	ID=PRO_0000124878;Note=Histone-lysine N-methyltransferase 2D
KMT2D	O14686	1694	1729	1729	1729	Alternative sequence	ID=VSP_008560;Note=In isoform 3. E->EGET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9247308;Dbxref=PMID:9247308
KMT2D	O14686	1694	1729	1718	1718	Natural variant	ID=VAR_074237;Note=In KABUK1%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21607748;Dbxref=dbSNP:rs111266743,PMID:21607748
PRPSAP2	O60256	268	317	1	369	Chain	ID=PRO_0000141082;Note=Phosphoribosyl pyrophosphate synthase-associated protein 2
PRPSAP2	O60256	268	317	269	317	Alternative sequence	ID=VSP_046462;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRPSAP2	O60256	268	317	263	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JI4
PRPSAP2	O60256	268	317	276	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JI4
PRPSAP2	O60256	268	317	292	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JI4
PRPSAP2	O60256	268	317	306	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JI4
PRPSAP2	O60256	268	317	317	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JI4
PHKA1	P46020	1099	1166	1	1223	Chain	ID=PRO_0000057726;Note=Phosphorylase b kinase regulatory subunit alpha%2C skeletal muscle isoform
PHKA1	P46020	1011	1024	1	1223	Chain	ID=PRO_0000057726;Note=Phosphorylase b kinase regulatory subunit alpha%2C skeletal muscle isoform
PHKA1	P46020	938	972	1	1223	Chain	ID=PRO_0000057726;Note=Phosphorylase b kinase regulatory subunit alpha%2C skeletal muscle isoform
PHKA1	P46020	653	712	1	1223	Chain	ID=PRO_0000057726;Note=Phosphorylase b kinase regulatory subunit alpha%2C skeletal muscle isoform
PHKA1	P46020	179	206	1	1223	Chain	ID=PRO_0000057726;Note=Phosphorylase b kinase regulatory subunit alpha%2C skeletal muscle isoform
PHKA1	P46020	938	972	972	972	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
PHKA1	P46020	1011	1024	1018	1018	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18688
PHKA1	P46020	1011	1024	1020	1020	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18688
PHKA1	P46020	1011	1024	1023	1023	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18688
PHKA1	P46020	1099	1166	1113	1113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64649
PHKA1	P46020	653	712	654	713	Alternative sequence	ID=VSP_042517;Note=In isoform 3. ARCGDEVARYLDHLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMSLVTKAKELHVQN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHKA1	P46020	1011	1024	1011	1023	Alternative sequence	ID=VSP_042518;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHKA1	P46020	1011	1024	1012	1024	Alternative sequence	ID=VSP_004697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8226841;Dbxref=PMID:15489334,PMID:8226841
KRBA1	A5PL33	51	103	1	1030	Chain	ID=PRO_0000300111;Note=Protein KRBA1
KRBA1	A5PL33	199	257	1	1030	Chain	ID=PRO_0000300111;Note=Protein KRBA1
KRBA1	A5PL33	309	375	1	1030	Chain	ID=PRO_0000300111;Note=Protein KRBA1
KRBA1	A5PL33	542	607	1	1030	Chain	ID=PRO_0000300111;Note=Protein KRBA1
KRBA1	A5PL33	607	654	1	1030	Chain	ID=PRO_0000300111;Note=Protein KRBA1
KRBA1	A5PL33	542	607	602	792	Compositional bias	Note=Pro-rich
KRBA1	A5PL33	607	654	602	792	Compositional bias	Note=Pro-rich
KRBA1	A5PL33	51	103	101	101	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KRBA1	A5PL33	199	257	229	229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KRBA1	A5PL33	199	257	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
KRBA1	A5PL33	309	375	355	355	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KRBA1	A5PL33	542	607	543	603	Alternative sequence	ID=VSP_027779;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KRBA1	A5PL33	309	375	320	320	Natural variant	ID=VAR_056922;Note=H->R;Dbxref=dbSNP:rs7791608
SLC25A3	Q00325	272	309	50	362	Chain	ID=PRO_0000019256;Note=Phosphate carrier protein%2C mitochondrial
SLC25A3	Q00325	272	309	50	362	Chain	ID=PRO_0000019256;Note=Phosphate carrier protein%2C mitochondrial
SLC25A3	Q00325	272	309	262	284	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A3	Q00325	272	309	262	284	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A3	Q00325	272	309	285	314	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A3	Q00325	272	309	285	314	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A3	Q00325	272	309	261	339	Repeat	Note=Solcar 3
SLC25A3	Q00325	272	309	261	339	Repeat	Note=Solcar 3
RPS6KC1	Q96S38	35	47	1	1066	Chain	ID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
RPS6KC1	Q96S38	157	278	1	1066	Chain	ID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
RPS6KC1	Q96S38	317	348	1	1066	Chain	ID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
RPS6KC1	Q96S38	348	364	1	1066	Chain	ID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
RPS6KC1	Q96S38	940	970	1	1066	Chain	ID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
RPS6KC1	Q96S38	998	1030	1	1066	Chain	ID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
RPS6KC1	Q96S38	35	47	8	132	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
RPS6KC1	Q96S38	157	278	277	305	Domain	Note=MIT
RPS6KC1	Q96S38	317	348	344	445	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KC1	Q96S38	348	364	344	445	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KC1	Q96S38	940	970	794	1056	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KC1	Q96S38	998	1030	794	1056	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KC1	Q96S38	35	47	36	47	Alternative sequence	ID=VSP_046333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KC1	Q96S38	35	47	42	42	Natural variant	ID=VAR_040647;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56087470,PMID:17344846
RPS6KC1	Q96S38	317	348	319	319	Natural variant	ID=VAR_040649;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56369827,PMID:17344846
RPS6KC1	Q96S38	998	1030	1003	1003	Natural variant	ID=VAR_040656;Note=In a lung adenocarcinoma sample%3B somatic mutation. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
RPS6KC1	Q96S38	998	1030	1022	1022	Natural variant	ID=VAR_040657;Note=In a breast infiltrating ductal carcinoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
RPS6KC1	Q96S38	35	47	35	35	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KC1	Q96S38	157	278	250	250	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYK	P43405	282	305	1	635	Chain	ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK
SYK	P43405	527	574	1	635	Chain	ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK
SYK	P43405	282	305	1	635	Chain	ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK
SYK	P43405	527	574	1	635	Chain	ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK
SYK	P43405	527	574	371	631	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SYK	P43405	527	574	371	631	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SYK	P43405	282	305	260	370	Region	Note=Interdomain B
SYK	P43405	282	305	260	370	Region	Note=Interdomain B
SYK	P43405	282	305	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	282	305	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	282	305	296	296	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	282	305	296	296	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	282	305	297	297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	282	305	297	297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	527	574	530	530	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	527	574	530	530	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	527	574	546	546	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48025
SYK	P43405	527	574	546	546	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48025
SYK	P43405	282	305	283	305	Alternative sequence	ID=VSP_005010;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SYK	P43405	282	305	283	305	Alternative sequence	ID=VSP_005010;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SYK	P43405	282	305	297	297	Mutagenesis	Note=Abolishes YWHAG binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	282	305	297	297	Mutagenesis	Note=Abolishes YWHAG binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132
SYK	P43405	527	574	524	527	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	524	527	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	536	538	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	536	538	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	541	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	541	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	548	550	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	548	550	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	551	566	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	551	566	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	567	569	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	567	569	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	572	575	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
SYK	P43405	527	574	572	575	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YJR
MPDU1	O75352	34	56	2	247	Chain	ID=PRO_0000221034;Note=Mannose-P-dolichol utilization defect 1 protein
MPDU1	O75352	34	56	37	57	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MPDU1	O75352	34	56	39	105	Domain	Note=PQ-loop 1
MROH2A	A6NES4	765	816	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	952	987	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	1068	1119	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	1289	1334	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	1482	1534	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	1534	1578	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	1612	1634	1	1674	Chain	ID=PRO_0000348053;Note=Maestro heat-like repeat-containing protein family member 2A
MROH2A	A6NES4	765	816	739	776	Repeat	Note=HEAT 10
MROH2A	A6NES4	1612	1634	1627	1674	Repeat	Note=HEAT 14
MROH2A	A6NES4	952	987	978	978	Natural variant	ID=VAR_046077;Note=W->R;Dbxref=dbSNP:rs726016
MROH2A	A6NES4	1068	1119	1075	1075	Natural variant	ID=VAR_046079;Note=S->T;Dbxref=dbSNP:rs17864722
MROH2A	A6NES4	1068	1119	1107	1107	Natural variant	ID=VAR_046080;Note=F->S;Dbxref=dbSNP:rs1500480
MROH2A	A6NES4	1534	1578	1537	1537	Natural variant	ID=VAR_046087;Note=M->V;Dbxref=dbSNP:rs11563074
MROH2A	A6NES4	1534	1578	1546	1546	Natural variant	ID=VAR_046088;Note=F->L;Dbxref=dbSNP:rs28900700
MROH2A	A6NES4	1534	1578	1562	1562	Natural variant	ID=VAR_046089;Note=A->T;Dbxref=dbSNP:rs879665
MROH2A	A6NES4	1534	1578	1569	1569	Natural variant	ID=VAR_046090;Note=V->I;Dbxref=dbSNP:rs879664
LGALSL	Q3ZCW2	12	36	2	172	Chain	ID=PRO_0000315766;Note=Galectin-related protein
LGALSL	Q3ZCW2	12	36	22	22	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
LGALSL	Q3ZCW2	12	36	25	25	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KEAP1	Q14145	510	569	1	624	Chain	ID=PRO_0000119093;Note=Kelch-like ECH-associated protein 1
KEAP1	Q14145	510	569	1	624	Chain	ID=PRO_0000119093;Note=Kelch-like ECH-associated protein 1
KEAP1	Q14145	510	569	471	517	Repeat	Note=Kelch 4
KEAP1	Q14145	510	569	471	517	Repeat	Note=Kelch 4
KEAP1	Q14145	510	569	518	564	Repeat	Note=Kelch 5
KEAP1	Q14145	510	569	518	564	Repeat	Note=Kelch 5
KEAP1	Q14145	510	569	565	611	Repeat	Note=Kelch 6
KEAP1	Q14145	510	569	565	611	Repeat	Note=Kelch 6
KEAP1	Q14145	510	569	522	522	Natural variant	ID=VAR_036085;Note=In a breast cancer sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
KEAP1	Q14145	510	569	522	522	Natural variant	ID=VAR_036085;Note=In a breast cancer sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
KEAP1	Q14145	510	569	525	525	Mutagenesis	Note=Loss of interaction with NFE2L2. Strongly reduces repression of NFE2L2-dependent gene expression. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16888629;Dbxref=PMID:16888629
KEAP1	Q14145	510	569	525	525	Mutagenesis	Note=Loss of interaction with NFE2L2. Strongly reduces repression of NFE2L2-dependent gene expression. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16888629;Dbxref=PMID:16888629
KEAP1	Q14145	510	569	511	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	511	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	518	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	518	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	527	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	527	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	534	538	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	534	538	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	539	542	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	539	542	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	543	547	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	543	547	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	558	562	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	558	562	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	565	569	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEAP1	Q14145	510	569	565	569	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZGK
KEL	P23276	531	567	1	732	Chain	ID=PRO_0000078227;Note=Kell blood group glycoprotein
KEL	P23276	401	438	1	732	Chain	ID=PRO_0000078227;Note=Kell blood group glycoprotein
KEL	P23276	531	567	68	732	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KEL	P23276	401	438	68	732	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KEL	P23276	401	438	406	406	Natural variant	ID=VAR_015124;Note=In KEL26 antigen. R->Q;Dbxref=dbSNP:rs61729041
KEL	P23276	531	567	548	548	Natural variant	ID=VAR_015126;Note=In KEL12 antigen. H->R;Dbxref=dbSNP:rs61729033
KIF5A	Q12840	97	132	2	1032	Chain	ID=PRO_0000125353;Note=Kinesin heavy chain isoform 5A
KIF5A	Q12840	97	132	9	327	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KLF5	Q13887	378	398	1	457	Chain	ID=PRO_0000047169;Note=Krueppel-like factor 5
KLF5	Q13887	378	398	373	397	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
KLF5	Q13887	378	398	167	457	Alternative sequence	ID=VSP_047476;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:23134681;Dbxref=PMID:23134681
KLF5	Q13887	378	398	377	379	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBT
KLF5	Q13887	378	398	383	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBT
KLF5	Q13887	378	398	387	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBT
KLRD1	Q13241	2	33	1	179	Chain	ID=PRO_0000046587;Note=Natural killer cells antigen CD94
KLRD1	Q13241	2	33	1	179	Chain	ID=PRO_0000046587;Note=Natural killer cells antigen CD94
KLRD1	Q13241	2	33	1	10	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRD1	Q13241	2	33	1	10	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRD1	Q13241	2	33	11	31	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRD1	Q13241	2	33	11	31	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRD1	Q13241	2	33	32	179	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRD1	Q13241	2	33	32	179	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRD1	Q13241	2	33	1	34	Alternative sequence	ID=VSP_003052;Note=In isoform 3. MAVFKTTLWRLISGTLGIICLSLMSTLGILLKNS->MAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9601951;Dbxref=PMID:9601951
KLRD1	Q13241	2	33	1	34	Alternative sequence	ID=VSP_003052;Note=In isoform 3. MAVFKTTLWRLISGTLGIICLSLMSTLGILLKNS->MAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9601951;Dbxref=PMID:9601951
KLRD1	Q13241	2	33	25	25	Natural variant	ID=VAR_050103;Note=S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7589107,ECO:0000269|PubMed:9472066;Dbxref=dbSNP:rs10772256,PMID:15489334,PMID:7589107,PMID:9472066
KLRD1	Q13241	2	33	25	25	Natural variant	ID=VAR_050103;Note=S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7589107,ECO:0000269|PubMed:9472066;Dbxref=dbSNP:rs10772256,PMID:15489334,PMID:7589107,PMID:9472066
KMT2C	Q8NEZ4	3820	3890	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1694	1755	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1424	1459	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1280	1320	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1166	1237	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1144	1166	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	957	992	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	844	884	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	3892	3947	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1694	1755	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1424	1459	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1280	1320	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1166	1237	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	1144	1166	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	957	992	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	844	884	1	4911	Chain	ID=PRO_0000124879;Note=Histone-lysine N-methyltransferase 2C
KMT2C	Q8NEZ4	957	992	957	1010	Zinc finger	Note=PHD-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
KMT2C	Q8NEZ4	957	992	957	1010	Zinc finger	Note=PHD-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
KMT2C	Q8NEZ4	1694	1755	1754	1787	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KMT2C	Q8NEZ4	1694	1755	1754	1787	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KMT2C	Q8NEZ4	1694	1755	1719	1796	Compositional bias	Note=Gln-rich
KMT2C	Q8NEZ4	1694	1755	1719	1796	Compositional bias	Note=Gln-rich
KMT2C	Q8NEZ4	844	884	854	854	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KMT2C	Q8NEZ4	844	884	854	854	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KMT2C	Q8NEZ4	1280	1320	1301	1301	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
KMT2C	Q8NEZ4	1280	1320	1301	1301	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
KMT2C	Q8NEZ4	844	884	1	939	Alternative sequence	ID=VSP_008561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11718452;Dbxref=PMID:11718452
KMT2C	Q8NEZ4	844	884	1	939	Alternative sequence	ID=VSP_008561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11718452;Dbxref=PMID:11718452
KMT2C	Q8NEZ4	3820	3890	3890	3890	Alternative sequence	ID=VSP_008562;Note=In isoform 2 and isoform 3. Q->QVRQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11718452;Dbxref=PMID:11718452
KMT2C	Q8NEZ4	3820	3890	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1694	1755	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1424	1459	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1280	1320	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1166	1237	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1144	1166	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	957	992	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	844	884	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	3892	3947	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1694	1755	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1424	1459	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1280	1320	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1166	1237	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1144	1166	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	957	992	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	844	884	564	4911	Natural variant	ID=VAR_080246;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	3820	3890	1481	4911	Natural variant	ID=VAR_080247;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22726846;Dbxref=PMID:22726846
KMT2C	Q8NEZ4	1694	1755	1481	4911	Natural variant	ID=VAR_080247;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22726846;Dbxref=PMID:22726846
KMT2C	Q8NEZ4	3892	3947	1481	4911	Natural variant	ID=VAR_080247;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22726846;Dbxref=PMID:22726846
KMT2C	Q8NEZ4	1694	1755	1481	4911	Natural variant	ID=VAR_080247;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22726846;Dbxref=PMID:22726846
KMT2C	Q8NEZ4	3820	3890	2517	4911	Natural variant	ID=VAR_080248;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	3892	3947	2517	4911	Natural variant	ID=VAR_080248;Note=In KLEFS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29069077;Dbxref=PMID:29069077
KMT2C	Q8NEZ4	1280	1320	1286	1286	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMT2C	Q8NEZ4	1280	1320	1286	1286	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMT2C	Q8NEZ4	1694	1755	1687	1706	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUK
KMT2C	Q8NEZ4	1694	1755	1687	1706	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUK
SLC16A2	P36021	342	390	2	539	Chain	ID=PRO_0000211401;Note=Monocarboxylate transporter 8
SLC16A2	P36021	342	390	323	343	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A2	P36021	342	390	344	356	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A2	P36021	342	390	357	377	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A2	P36021	342	390	378	386	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A2	P36021	342	390	387	407	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A2	P36021	342	390	360	360	Natural variant	ID=VAR_059057;Note=In MCT8 deficiency%3B impaired homodimerization. L->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15889350,ECO:0000269|PubMed:25527620;Dbxref=dbSNP:rs104894939,PMID:15889350,PMID:25527620
SLC16A2	P36021	342	390	371	371	Natural variant	ID=VAR_074577;Note=In MCT8 deficiency%3B impaired homodimerization. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25527620;Dbxref=dbSNP:rs587784384,PMID:25527620
SLC16A2	P36021	342	390	379	379	Natural variant	ID=VAR_074578;Note=In MCT8 deficiency%3B impaired thyroid hormone transporter activity%3B does not affect localization to the cell membrane. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23550058;Dbxref=PMID:23550058
SLC16A2	P36021	342	390	376	376	Mutagenesis	Note=No effect on thyroid hormone (TH) transport. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23610131;Dbxref=PMID:23610131
PRKCD	Q05655	451	471	1	676	Chain	ID=PRO_0000055694;Note=Protein kinase C delta type
PRKCD	Q05655	518	581	1	676	Chain	ID=PRO_0000055694;Note=Protein kinase C delta type
PRKCD	Q05655	581	624	1	676	Chain	ID=PRO_0000055694;Note=Protein kinase C delta type
PRKCD	Q05655	451	471	1	676	Chain	ID=PRO_0000055694;Note=Protein kinase C delta type
PRKCD	Q05655	518	581	1	676	Chain	ID=PRO_0000055694;Note=Protein kinase C delta type
PRKCD	Q05655	581	624	1	676	Chain	ID=PRO_0000055694;Note=Protein kinase C delta type
PRKCD	Q05655	451	471	330	676	Chain	ID=PRO_0000421668;Note=Protein kinase C delta type catalytic subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRKCD	Q05655	518	581	330	676	Chain	ID=PRO_0000421668;Note=Protein kinase C delta type catalytic subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRKCD	Q05655	581	624	330	676	Chain	ID=PRO_0000421668;Note=Protein kinase C delta type catalytic subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRKCD	Q05655	451	471	330	676	Chain	ID=PRO_0000421668;Note=Protein kinase C delta type catalytic subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRKCD	Q05655	518	581	330	676	Chain	ID=PRO_0000421668;Note=Protein kinase C delta type catalytic subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRKCD	Q05655	581	624	330	676	Chain	ID=PRO_0000421668;Note=Protein kinase C delta type catalytic subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRKCD	Q05655	451	471	349	603	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCD	Q05655	518	581	349	603	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCD	Q05655	581	624	349	603	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCD	Q05655	451	471	349	603	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCD	Q05655	518	581	349	603	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCD	Q05655	581	624	349	603	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCD	Q05655	581	624	604	675	Domain	Note=AGC-kinase C-terminal
PRKCD	Q05655	581	624	604	675	Domain	Note=AGC-kinase C-terminal
PRKCD	Q05655	451	471	451	451	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17965192;Dbxref=PMID:17965192
PRKCD	Q05655	451	471	451	451	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17965192;Dbxref=PMID:17965192
PRKCD	Q05655	518	581	567	567	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17570831;Dbxref=PMID:17570831
PRKCD	Q05655	518	581	567	567	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17570831;Dbxref=PMID:17570831
PRKCD	Q05655	581	624	593	593	Natural variant	ID=VAR_006176;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8357834;Dbxref=PMID:8357834
PRKCD	Q05655	581	624	593	593	Natural variant	ID=VAR_006176;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8357834;Dbxref=PMID:8357834
PRKCD	Q05655	518	581	524	524	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRKCD	Q05655	518	581	524	524	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRKCD	Q05655	518	581	533	533	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRKCD	Q05655	518	581	533	533	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRKCG	P05129	552	588	1	697	Chain	ID=PRO_0000055689;Note=Protein kinase C gamma type
PRKCG	P05129	588	635	1	697	Chain	ID=PRO_0000055689;Note=Protein kinase C gamma type
PRKCG	P05129	552	588	351	614	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCG	P05129	588	635	351	614	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCG	P05129	588	635	615	685	Domain	Note=AGC-kinase C-terminal
PRKCG	P05129	552	588	553	588	Alternative sequence	ID=VSP_056469;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRKCG	P05129	588	635	553	588	Alternative sequence	ID=VSP_056469;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KRI1	Q8N9T8	201	227	1	703	Chain	ID=PRO_0000298976;Note=Protein KRI1 homolog
KRI1	Q8N9T8	201	227	98	423	Compositional bias	Note=Glu-rich
RPS6KA3	P51812	534	588	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	481	534	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	451	481	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	108	135	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	42	81	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	108	135	68	327	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	42	81	68	327	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	534	588	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	481	534	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	451	481	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	42	81	74	82	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	534	588	539	539	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPS6KA3	P51812	451	481	451	451	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	481	534	529	529	Modified residue	Note=Phosphotyrosine%3B by FGFR3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18654
RPS6KA3	P51812	534	588	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
RPS6KA3	P51812	42	81	75	75	Natural variant	ID=VAR_006189;Note=In CLS. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8955270;Dbxref=dbSNP:rs122454124,PMID:8955270
RPS6KA3	P51812	108	135	114	114	Natural variant	ID=VAR_006191;Note=In CLS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10094187;Dbxref=dbSNP:rs122454127,PMID:10094187
RPS6KA3	P51812	108	135	115	115	Natural variant	ID=VAR_065892;Note=In MRX19. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17100996;Dbxref=dbSNP:rs387906703,PMID:17100996
RPS6KA3	P51812	108	135	127	127	Natural variant	ID=VAR_006192;Note=In CLS. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9837815;Dbxref=PMID:9837815
RPS6KA3	P51812	451	481	477	477	Natural variant	ID=VAR_065898;Note=In CLS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15214012;Dbxref=PMID:15214012
RPS6KA3	P51812	481	534	483	483	Natural variant	ID=VAR_040629;Note=In a gastric adenocarcinoma sample%3B somatic mutation. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1271090915,PMID:17344846
RPS6KA3	P51812	451	481	480	480	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA3	P51812	481	534	494	494	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA3	P51812	42	81	50	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9L
RPS6KA3	P51812	42	81	65	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	42	81	68	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	42	81	78	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	108	135	109	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	108	135	133	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	451	481	446	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	451	481	455	457	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	451	481	461	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	451	481	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	486	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	501	506	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	513	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	542	544	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	545	551	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	554	556	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	557	559	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	571	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JG8
RPS6KA3	P51812	534	588	587	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
KYNU	Q16719	194	243	1	465	Chain	ID=PRO_0000218657;Note=Kynureninase
KYNU	Q16719	194	243	1	465	Chain	ID=PRO_0000218657;Note=Kynureninase
KYNU	Q16719	194	243	221	221	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03017
KYNU	Q16719	194	243	221	221	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03017
KYNU	Q16719	194	243	156	465	Natural variant	ID=VAR_080254;Note=In VCRL2%3B strongly reduced 3-hydroxykynureninase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28792876;Dbxref=PMID:28792876
KYNU	Q16719	194	243	156	465	Natural variant	ID=VAR_080254;Note=In VCRL2%3B strongly reduced 3-hydroxykynureninase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28792876;Dbxref=PMID:28792876
KYNU	Q16719	194	243	198	198	Natural variant	ID=VAR_054401;Note=In HYXKY%3B reduced 3-hydroxykynureninase activity. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17334708,ECO:0000269|PubMed:28792876;Dbxref=dbSNP:rs606231307,PMID:17334708,PMID:28792876
KYNU	Q16719	194	243	198	198	Natural variant	ID=VAR_054401;Note=In HYXKY%3B reduced 3-hydroxykynureninase activity. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17334708,ECO:0000269|PubMed:28792876;Dbxref=dbSNP:rs606231307,PMID:17334708,PMID:28792876
KYNU	Q16719	194	243	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	212	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	212	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	215	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	215	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	233	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KYNU	Q16719	194	243	233	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E9K
KPNA5	O15131	46	80	1	536	Chain	ID=PRO_0000120728;Note=Importin subunit alpha-6
KPNA5	O15131	46	80	1	536	Chain	ID=PRO_0000120728;Note=Importin subunit alpha-6
KPNA5	O15131	46	80	2	57	Domain	Note=IBB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00561
KPNA5	O15131	46	80	2	57	Domain	Note=IBB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00561
KPNA5	O15131	46	80	73	115	Repeat	Note=ARM 1%3B truncated
KPNA5	O15131	46	80	73	115	Repeat	Note=ARM 1%3B truncated
KPNA5	O15131	46	80	42	51	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA5	O15131	46	80	42	51	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA5	O15131	46	80	67	67	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA5	O15131	46	80	67	67	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA5	O15131	46	80	79	79	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA5	O15131	46	80	79	79	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA6	O60684	142	186	1	536	Chain	ID=PRO_0000120729;Note=Importin subunit alpha-7
KPNA6	O60684	142	186	116	159	Repeat	Note=ARM 2
KPNA6	O60684	142	186	160	204	Repeat	Note=ARM 3
KPNA6	O60684	142	186	147	239	Region	Note=NLS binding site (major);Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA6	O60684	142	186	139	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAD
KPNA6	O60684	142	186	157	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAD
KPNA6	O60684	142	186	168	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAD
KPNA6	O60684	142	186	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAD
KPNA6	O60684	142	186	181	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAD
INSC	Q1MX18	240	278	1	579	Chain	ID=PRO_0000252405;Note=Protein inscuteable homolog
INSC	Q1MX18	278	320	1	579	Chain	ID=PRO_0000252405;Note=Protein inscuteable homolog
INSC	Q1MX18	240	278	278	319	Alternative sequence	ID=VSP_020950;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INSC	Q1MX18	278	320	278	319	Alternative sequence	ID=VSP_020950;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INSC	Q1MX18	240	278	251	251	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITPKB	P27987	851	875	1	946	Chain	ID=PRO_0000066868;Note=Inositol-trisphosphate 3-kinase B
ITPKB	P27987	851	875	1	946	Chain	ID=PRO_0000066868;Note=Inositol-trisphosphate 3-kinase B
ITPKB	P27987	851	875	645	946	Alternative sequence	ID=VSP_016092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ITPKB	P27987	851	875	645	946	Alternative sequence	ID=VSP_016092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IRF2	P14316	176	231	1	349	Chain	ID=PRO_0000154549;Note=Interferon regulatory factor 2
IRF2	P14316	176	231	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
IRF2	P14316	176	231	177	178	Alternative sequence	ID=VSP_043965;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITLN1	Q8WWA0	135	188	19	298	Chain	ID=PRO_0000009143;Note=Intelectin-1
ITLN1	Q8WWA0	19	52	19	298	Chain	ID=PRO_0000009143;Note=Intelectin-1
ITLN1	Q8WWA0	135	188	32	255	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
ITLN1	Q8WWA0	19	52	32	255	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
ITLN1	Q8WWA0	135	188	163	163	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITLN1	Q8WWA0	19	52	31	31	Disulfide bond	Note=Interchain (with C-48);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:4WMQ,ECO:0000244|PDB:4WMY,ECO:0000255|PROSITE-ProRule:PRU00739,ECO:0000269|PubMed:17621593,ECO:0000269|PubMed:26148048;Dbxref=PMID:17621593,PMID:26148048
ITLN1	Q8WWA0	19	52	41	70	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4WMQ,ECO:0000244|PDB:4WMY,ECO:0000269|PubMed:26148048;Dbxref=PMID:26148048
ITLN1	Q8WWA0	19	52	48	48	Disulfide bond	Note=Interchain (with C-31);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:4WMQ,ECO:0000244|PDB:4WMY,ECO:0000255|PROSITE-ProRule:PRU00739,ECO:0000269|PubMed:17621593,ECO:0000269|PubMed:26148048;Dbxref=PMID:17621593,PMID:26148048
ITLN1	Q8WWA0	135	188	94	280	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4WMQ,ECO:0000244|PDB:4WMY,ECO:0000269|PubMed:26148048;Dbxref=PMID:26148048
ITLN1	Q8WWA0	19	52	31	31	Mutagenesis	Note=Forms mainly monomers%3B when associated with S-48. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17621593;Dbxref=PMID:17621593
ITLN1	Q8WWA0	19	52	48	48	Mutagenesis	Note=Forms mainly dimers. Forms mainly monomers%3B when associated with S-31. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17621593;Dbxref=PMID:17621593
ITLN1	Q8WWA0	19	52	41	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	138	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	145	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	158	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	161	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	166	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	178	180	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITLN1	Q8WWA0	135	188	183	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMY
ITGAX	P20702	720	764	20	1163	Chain	ID=PRO_0000016294;Note=Integrin alpha-X
ITGAX	P20702	720	764	20	1107	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAX	P20702	720	764	735	735	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGAX	P20702	720	764	639	722	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGAX	P20702	720	764	756	756	Sequence conflict	Note=D->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGAX	P20702	720	764	726	728	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES4
ITGAX	P20702	720	764	730	740	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NEH
ITGAX	P20702	720	764	744	747	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NEH
ITGAX	P20702	720	764	760	765	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NEH
ITGB1BP1	O14713	127	177	1	200	Chain	ID=PRO_0000084264;Note=Integrin beta-1-binding protein 1
ITGB1BP1	O14713	127	177	1	200	Chain	ID=PRO_0000084264;Note=Integrin beta-1-binding protein 1
ITGB1BP1	O14713	127	177	58	200	Domain	Note=PID
ITGB1BP1	O14713	127	177	58	200	Domain	Note=PID
ITGB1BP1	O14713	127	177	136	139	Region	Note=Interaction with KRIT1
ITGB1BP1	O14713	127	177	136	139	Region	Note=Interaction with KRIT1
ITGB1BP1	O14713	127	177	139	141	Region	Note=Interaction with ITGB1
ITGB1BP1	O14713	127	177	139	141	Region	Note=Interaction with ITGB1
ITGB1BP1	O14713	127	177	128	177	Alternative sequence	ID=VSP_003898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9281591;Dbxref=PMID:9281591
ITGB1BP1	O14713	127	177	128	177	Alternative sequence	ID=VSP_003898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9281591;Dbxref=PMID:9281591
ITGB1BP1	O14713	127	177	135	139	Mutagenesis	Note=Reduces KRIT1 and ITGB1 binding. LYLII->AYAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.19
ITGB1BP1	O14713	127	177	135	139	Mutagenesis	Note=Reduces KRIT1 and ITGB1 binding. LYLII->AYAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.19
ITGB1BP1	O14713	127	177	135	135	Mutagenesis	Note=Abolishes ITGB1 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741908;Dbxref=PMID:11741908
ITGB1BP1	O14713	127	177	135	135	Mutagenesis	Note=Abolishes ITGB1 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741908;Dbxref=PMID:11741908
ITGB1BP1	O14713	127	177	138	138	Mutagenesis	Note=Abolishes ITGB1 binding. I->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11741908,ECO:0000269|PubMed:15703214;Dbxref=PMID:11741908,PMID:15703214
ITGB1BP1	O14713	127	177	138	138	Mutagenesis	Note=Abolishes ITGB1 binding. I->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11741908,ECO:0000269|PubMed:15703214;Dbxref=PMID:11741908,PMID:15703214
ITGB1BP1	O14713	127	177	139	139	Mutagenesis	Note=Abolishes ITGB1 binding. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741908;Dbxref=PMID:11741908
ITGB1BP1	O14713	127	177	139	139	Mutagenesis	Note=Abolishes ITGB1 binding. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741908;Dbxref=PMID:11741908
ITGB1BP1	O14713	127	177	144	144	Mutagenesis	Note=Abolishes ITGB1 binding. Y->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741908;Dbxref=PMID:11741908
ITGB1BP1	O14713	127	177	144	144	Mutagenesis	Note=Abolishes ITGB1 binding. Y->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741908;Dbxref=PMID:11741908
ITGB1BP1	O14713	127	177	150	150	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGB1BP1	O14713	127	177	150	150	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGB1BP1	O14713	127	177	129	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	129	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	135	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	135	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	138	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	138	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	148	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	148	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	153	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	153	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	167	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	167	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	177	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
ITGB1BP1	O14713	127	177	177	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JIF
IGSF3	O75054	407	541	20	1194	Chain	ID=PRO_0000320134;Note=Immunoglobulin superfamily member 3
IGSF3	O75054	407	541	20	1124	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF3	O75054	407	541	401	539	Domain	Note=Ig-like C2-type 4
IGSF3	O75054	407	541	418	418	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF3	O75054	407	541	432	511	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF3	O75054	407	541	407	408	Alternative sequence	ID=VSP_031609;Note=In isoform 2. LK->LTDNWVVKVPQHHQLLSQGHLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9790749;Dbxref=PMID:9790749
IGBP1	P78318	63	160	2	339	Chain	ID=PRO_0000218618;Note=Immunoglobulin-binding protein 1
IGBP1	P78318	63	160	98	202	Region	Note=Interaction with PPP2CA
IGBP1	P78318	63	160	155	155	Mutagenesis	Note=Abolishes interaction with PPP2CA. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23591866;Dbxref=PMID:23591866
IGBP1	P78318	63	160	158	158	Mutagenesis	Note=Abolishes interaction with PPP2CA. K->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23591866;Dbxref=PMID:23591866
IGBP1	P78318	63	160	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	73	75	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	76	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	81	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	98	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	143	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
IGBP1	P78318	63	160	156	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IYP
NFKBIE	O00221	399	479	1	500	Chain	ID=PRO_0000067007;Note=NF-kappa-B inhibitor epsilon
NFKBIE	O00221	399	479	403	432	Repeat	Note=ANK 5
NFKBIE	O00221	399	479	436	465	Repeat	Note=ANK 6
NFKBIE	O00221	399	479	402	402	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL12A	P29459	88	126	23	219	Chain	ID=PRO_0000015604;Note=Interleukin-12 subunit alpha
IL12A	P29459	126	140	23	219	Chain	ID=PRO_0000015604;Note=Interleukin-12 subunit alpha
IL12A	P29459	88	126	93	93	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12A	P29459	88	126	107	107	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL12A	P29459	88	126	64	196	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10899108;Dbxref=PMID:10899108
IL12A	P29459	126	140	64	196	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10899108;Dbxref=PMID:10899108
IL12A	P29459	88	126	85	123	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10899108;Dbxref=PMID:10899108
IL12A	P29459	88	126	96	96	Disulfide bond	Note=Interchain (with C-199 in IL12B);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10899108;Dbxref=PMID:10899108
IL12A	P29459	88	126	88	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F45
IL12A	P29459	88	126	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HMX
IL12A	P29459	88	126	114	116	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HMX
IL12A	P29459	88	126	118	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F45
IL12A	P29459	126	140	118	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F45
ILDR2	Q71H61	234	293	21	639	Chain	ID=PRO_0000278607;Note=Immunoglobulin-like domain-containing receptor 2
ILDR2	Q71H61	166	185	21	639	Chain	ID=PRO_0000278607;Note=Immunoglobulin-like domain-containing receptor 2
ILDR2	Q71H61	166	185	21	186	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR2	Q71H61	234	293	208	639	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL36G	Q9NZH8	18	53	18	169	Chain	ID=PRO_0000153648;Note=Interleukin-36 gamma
IL36G	Q9NZH8	18	53	19	54	Alternative sequence	ID=VSP_013002;Note=In isoform 2. MCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPV->I;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
IL36G	Q9NZH8	18	53	23	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IZE
IL36G	Q9NZH8	18	53	33	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IZE
IL36G	Q9NZH8	18	53	41	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IZE
IL36G	Q9NZH8	18	53	47	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IZE
ILDR1	Q86SU0	215	259	24	546	Chain	ID=PRO_0000245304;Note=Immunoglobulin-like domain-containing receptor 1
ILDR1	Q86SU0	166	215	24	546	Chain	ID=PRO_0000245304;Note=Immunoglobulin-like domain-containing receptor 1
ILDR1	Q86SU0	178	227	24	546	Chain	ID=PRO_0000245304;Note=Immunoglobulin-like domain-containing receptor 1
ILDR1	Q86SU0	166	215	24	167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR1	Q86SU0	166	215	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR1	Q86SU0	178	227	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR1	Q86SU0	215	259	189	546	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR1	Q86SU0	166	215	189	546	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR1	Q86SU0	178	227	189	546	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ILDR1	Q86SU0	166	215	188	212	Compositional bias	Note=Cys-rich
ILDR1	Q86SU0	178	227	188	212	Compositional bias	Note=Cys-rich
ILDR1	Q86SU0	166	215	92	209	Alternative sequence	ID=VSP_019680;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ILDR1	Q86SU0	178	227	92	209	Alternative sequence	ID=VSP_019680;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ILDR1	Q86SU0	215	259	128	216	Alternative sequence	ID=VSP_019682;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15381095;Dbxref=PMID:15381095
ILDR1	Q86SU0	166	215	128	216	Alternative sequence	ID=VSP_019682;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15381095;Dbxref=PMID:15381095
ILDR1	Q86SU0	178	227	128	216	Alternative sequence	ID=VSP_019682;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15381095;Dbxref=PMID:15381095
ILDR1	Q86SU0	215	259	216	259	Alternative sequence	ID=VSP_019683;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15381095,ECO:0000303|PubMed:15489334;Dbxref=PMID:15381095,PMID:15489334
ILDR1	Q86SU0	178	227	216	259	Alternative sequence	ID=VSP_019683;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15381095,ECO:0000303|PubMed:15489334;Dbxref=PMID:15381095,PMID:15489334
ILVBL	A1L0T0	350	395	1	632	Chain	ID=PRO_0000314825;Note=Acetolactate synthase-like protein
ILVBL	A1L0T0	350	395	374	374	Natural variant	ID=VAR_038064;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856373,PMID:15489334
IPO13	O94829	274	320	1	963	Chain	ID=PRO_0000120758;Note=Importin-13
IPO13	O94829	628	676	1	963	Chain	ID=PRO_0000120758;Note=Importin-13
IPO13	O94829	676	703	1	963	Chain	ID=PRO_0000120758;Note=Importin-13
IPO13	O94829	841	871	1	963	Chain	ID=PRO_0000120758;Note=Importin-13
IPO13	O94829	274	320	276	325	Repeat	Note=HEAT 7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20122403;Dbxref=PMID:20122403
IPO13	O94829	628	676	603	648	Repeat	Note=HEAT 14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20122403;Dbxref=PMID:20122403
IPO13	O94829	628	676	676	716	Repeat	Note=HEAT 15;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20122403;Dbxref=PMID:20122403
IPO13	O94829	676	703	676	716	Repeat	Note=HEAT 15;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20122403;Dbxref=PMID:20122403
IPO13	O94829	841	871	815	845	Repeat	Note=HEAT 18;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20122403;Dbxref=PMID:20122403
IPO13	O94829	841	871	860	893	Repeat	Note=HEAT 19;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20122403;Dbxref=PMID:20122403
IPO13	O94829	274	320	272	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	274	320	276	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	274	320	290	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	274	320	302	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	628	676	631	650	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	628	676	676	695	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	676	703	676	695	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	676	703	699	715	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	841	871	831	844	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	841	871	845	847	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	841	871	853	857	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	841	871	858	860	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IPO13	O94829	841	871	862	873	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X19
IQGAP3	Q86VI3	1524	1557	1	1631	Chain	ID=PRO_0000056651;Note=Ras GTPase-activating-like protein IQGAP3
IQGAP3	Q86VI3	1094	1140	1	1631	Chain	ID=PRO_0000056651;Note=Ras GTPase-activating-like protein IQGAP3
IQGAP3	Q86VI3	768	796	1	1631	Chain	ID=PRO_0000056651;Note=Ras GTPase-activating-like protein IQGAP3
IQGAP3	Q86VI3	711	768	1	1631	Chain	ID=PRO_0000056651;Note=Ras GTPase-activating-like protein IQGAP3
IQGAP3	Q86VI3	168	206	1	1631	Chain	ID=PRO_0000056651;Note=Ras GTPase-activating-like protein IQGAP3
IQGAP3	Q86VI3	711	768	730	759	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP3	Q86VI3	768	796	760	789	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP3	Q86VI3	711	768	760	789	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP3	Q86VI3	768	796	790	819	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP3	Q86VI3	1094	1140	988	1221	Domain	Note=Ras-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00167
IQGAP3	Q86VI3	768	796	770	770	Natural variant	ID=VAR_055282;Note=H->Y;Dbxref=dbSNP:rs1078890
IQGAP3	Q86VI3	1094	1140	1097	1097	Natural variant	ID=VAR_055284;Note=P->S;Dbxref=dbSNP:rs12562301
IQGAP3	Q86VI3	1524	1557	1535	1538	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ISU
IQGAP3	Q86VI3	1524	1557	1539	1544	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ISU
IQGAP3	Q86VI3	1524	1557	1547	1551	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ISU
IQGAP3	Q86VI3	1524	1557	1556	1561	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ISU
CHCHD3	Q9NX63	123	151	2	227	Chain	ID=PRO_0000129163;Note=MICOS complex subunit MIC19
CHCHD3	Q9NX63	123	151	142	142	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MIOS	Q9NXC5	464	549	1	875	Chain	ID=PRO_0000329404;Note=GATOR complex protein MIOS
MIOS	Q9NXC5	628	681	1	875	Chain	ID=PRO_0000329404;Note=GATOR complex protein MIOS
MIOS	Q9NXC5	464	549	1	875	Chain	ID=PRO_0000329404;Note=GATOR complex protein MIOS
MIOS	Q9NXC5	628	681	1	875	Chain	ID=PRO_0000329404;Note=GATOR complex protein MIOS
MIOS	Q9NXC5	628	681	568	875	Alternative sequence	ID=VSP_032980;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MIOS	Q9NXC5	628	681	568	875	Alternative sequence	ID=VSP_032980;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLF11	O14901	14	104	1	512	Chain	ID=PRO_0000047180;Note=Krueppel-like factor 11
KLF11	O14901	14	104	1	17	Alternative sequence	ID=VSP_042695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLF11	O14901	14	104	62	62	Natural variant	ID=VAR_031522;Note=High frequency in individuals with diabetes mellitus type 2%3B increased repression activity%3B increased binding to SIN3A%3B impairs activation of insulin promoter. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15774581;Dbxref=dbSNP:rs35927125,PMID:15774581
KLHDC2	Q9Y2U9	183	211	1	406	Chain	ID=PRO_0000119127;Note=Kelch domain-containing protein 2
KLHDC2	Q9Y2U9	183	211	157	202	Repeat	Note=Kelch 3
KIT	P10721	591	626	26	976	Chain	ID=PRO_0000016754;Note=Mast/stem cell growth factor receptor Kit
KIT	P10721	591	626	546	976	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIT	P10721	591	626	589	937	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
KIT	P10721	591	626	596	603	Nucleotide binding	Note=ATP
KIT	P10721	591	626	623	623	Binding site	Note=ATP
KIT	P10721	591	626	414	976	Alternative sequence	ID=VSP_041867;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
KIT	P10721	591	626	601	601	Natural variant	ID=VAR_033130;Note=In PBT. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11074500;Dbxref=PMID:11074500
KIT	P10721	591	626	623	623	Mutagenesis	Note=Stronger interaction with MPDZ. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11018522;Dbxref=PMID:11018522
KIT	P10721	591	626	589	597	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T46
KIT	P10721	591	626	599	613	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T46
KIT	P10721	591	626	617	625	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T46
KLHL8	Q9P2G9	317	365	2	620	Chain	ID=PRO_0000119108;Note=Kelch-like protein 8
KLHL8	Q9P2G9	72	255	2	620	Chain	ID=PRO_0000119108;Note=Kelch-like protein 8
KLHL8	Q9P2G9	317	365	2	620	Chain	ID=PRO_0000119108;Note=Kelch-like protein 8
KLHL8	Q9P2G9	72	255	2	620	Chain	ID=PRO_0000119108;Note=Kelch-like protein 8
KLHL8	Q9P2G9	72	255	67	134	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
KLHL8	Q9P2G9	72	255	67	134	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
KLHL8	Q9P2G9	72	255	169	270	Domain	Note=BACK
KLHL8	Q9P2G9	72	255	169	270	Domain	Note=BACK
KLHL8	Q9P2G9	317	365	319	366	Repeat	Note=Kelch 1
KLHL8	Q9P2G9	317	365	319	366	Repeat	Note=Kelch 1
KLHL8	Q9P2G9	72	255	73	148	Alternative sequence	ID=VSP_054443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KLHL8	Q9P2G9	72	255	73	148	Alternative sequence	ID=VSP_054443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MON1B	Q7L1V2	49	158	1	547	Chain	ID=PRO_0000285765;Note=Vacuolar fusion protein MON1 homolog B
MON1B	Q7L1V2	49	158	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MON1B	Q7L1V2	49	158	61	61	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MON1B	Q7L1V2	49	158	13	158	Alternative sequence	ID=VSP_054665;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KNCN	A6PVL3	50	73	1	124	Chain	ID=PRO_0000311265;Note=Kinocilin
KNCN	A6PVL3	50	73	40	60	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KNCN	A6PVL3	50	73	51	73	Alternative sequence	ID=VSP_040405;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PHKB	Q93100	375	401	2	1093	Chain	ID=PRO_0000057736;Note=Phosphorylase b kinase regulatory subunit beta
PHKB	Q93100	564	599	2	1093	Chain	ID=PRO_0000057736;Note=Phosphorylase b kinase regulatory subunit beta
PHKA2	P46019	1094	1112	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	1019	1037	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	1009	1019	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	654	712	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	379	415	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	206	239	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	179	206	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	79	95	1	1235	Chain	ID=PRO_0000057730;Note=Phosphorylase b kinase regulatory subunit alpha%2C liver isoform
PHKA2	P46019	1094	1112	1059	1099	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
PHKA2	P46019	654	712	695	695	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHKA2	P46019	1009	1019	1015	1015	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:23186163
PHKA2	P46019	179	206	186	186	Natural variant	ID=VAR_006180;Note=In GSD9A%3B type 2. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10330341,ECO:0000269|PubMed:8733133;Dbxref=dbSNP:rs137852294,PMID:10330341,PMID:8733133
PHKA2	P46019	179	206	186	186	Natural variant	ID=VAR_006181;Note=In GSD9A%3B type 2. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10330341,ECO:0000269|PubMed:8733134;Dbxref=dbSNP:rs137852290,PMID:10330341,PMID:8733134
PHKA2	P46019	179	206	189	190	Natural variant	ID=VAR_012270;Note=In GSD9A%3B type 2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10330341;Dbxref=PMID:10330341
PHKA2	P46019	179	206	189	189	Natural variant	ID=VAR_012269;Note=In GSD9A%3B type 2. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600238;Dbxref=dbSNP:rs137852295,PMID:9600238
PHKA2	P46019	179	206	193	193	Natural variant	ID=VAR_012271;Note=In GSD9A%3B type 2. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7549948;Dbxref=PMID:7549948
PHKA2	P46019	379	415	399	399	Natural variant	ID=VAR_012273;Note=In GSD9A%3B type 1. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600238;Dbxref=PMID:9600238
PHKA2	P46019	1094	1112	1111	1111	Natural variant	ID=VAR_006184;Note=In GSD9A%3B type 2. R->RTR
CDC25A	P30304	143	183	1	524	Chain	ID=PRO_0000198641;Note=M-phase inducer phosphatase 1
CDC25A	P30304	143	183	141	143	Motif	Note=KEN box
CDC25A	P30304	143	183	178	178	Modified residue	Note=Phosphoserine%3B by CHEK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676583,ECO:0000269|PubMed:12759351,ECO:0000269|PubMed:14559997;Dbxref=PMID:12676583,PMID:12759351,PMID:14559997
CDC25A	P30304	143	183	144	183	Alternative sequence	ID=VSP_000860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11139144,ECO:0000303|Ref.2;Dbxref=PMID:11139144
CDC25A	P30304	143	183	182	182	Natural variant	ID=VAR_023532;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1836978;Dbxref=dbSNP:rs6771386,PMID:1836978
CDC25A	P30304	143	183	182	182	Natural variant	ID=VAR_023533;Note=R->W;Dbxref=dbSNP:rs6771386
CDC25A	P30304	143	183	141	143	Mutagenesis	Note=Prevents ubiquitination and subsequent degradation by the APC/C ubiquitin ligase complex. KEN->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12234927;Dbxref=PMID:12234927
CDC25A	P30304	143	183	178	178	Mutagenesis	Note=Increases basal stability and impairs CHEK1-dependent degradation following checkpoint activation%3B when associated with A-124%3B A-279 and A-293. Abrogates 14-3-3 protein binding. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676583,ECO:0000269|PubMed:12759351,ECO:0000269|PubMed:14559997;Dbxref=PMID:12676583,PMID:12759351,PMID:14559997
CDC25A	P30304	143	183	180	181	Sequence conflict	Note=PA->QL;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC25C	P30307	288	309	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	254	288	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	153	205	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	123	153	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	288	309	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	254	288	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	153	205	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	123	153	2	473	Chain	ID=PRO_0000198647;Note=M-phase inducer phosphatase 3
CDC25C	P30307	123	153	129	129	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	123	153	129	129	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	123	153	130	130	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	123	153	130	130	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	153	205	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18691976,ECO:0000269|PubMed:8119945;Dbxref=PMID:18691976,PMID:8119945
CDC25C	P30307	153	205	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18691976,ECO:0000269|PubMed:8119945;Dbxref=PMID:18691976,PMID:8119945
CDC25C	P30307	153	205	191	191	Modified residue	Note=Phosphoserine%3B by PLK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	153	205	191	191	Modified residue	Note=Phosphoserine%3B by PLK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	153	205	198	198	Modified residue	Note=Phosphoserine%3B by PLK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	153	205	198	198	Modified residue	Note=Phosphoserine%3B by PLK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	123	153	66	123	Alternative sequence	ID=VSP_000863;Note=In isoform 4 and isoform 5. GTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSP->SPGFFRTSGSAFSWD;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11078813,ECO:0000303|PubMed:11139144;Dbxref=PMID:11078813,PMID:11139144
CDC25C	P30307	123	153	66	123	Alternative sequence	ID=VSP_000863;Note=In isoform 4 and isoform 5. GTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSP->SPGFFRTSGSAFSWD;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11078813,ECO:0000303|PubMed:11139144;Dbxref=PMID:11078813,PMID:11139144
CDC25C	P30307	153	205	124	153	Alternative sequence	ID=VSP_000864;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11078813,ECO:0000303|PubMed:11139144;Dbxref=PMID:11078813,PMID:11139144
CDC25C	P30307	123	153	124	153	Alternative sequence	ID=VSP_000864;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11078813,ECO:0000303|PubMed:11139144;Dbxref=PMID:11078813,PMID:11139144
CDC25C	P30307	153	205	124	153	Alternative sequence	ID=VSP_000864;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11078813,ECO:0000303|PubMed:11139144;Dbxref=PMID:11078813,PMID:11139144
CDC25C	P30307	123	153	124	153	Alternative sequence	ID=VSP_000864;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11078813,ECO:0000303|PubMed:11139144;Dbxref=PMID:11078813,PMID:11139144
CDC25C	P30307	288	309	297	297	Natural variant	ID=VAR_020146;Note=G->R;Dbxref=dbSNP:rs11567997
CDC25C	P30307	288	309	297	297	Natural variant	ID=VAR_020146;Note=G->R;Dbxref=dbSNP:rs11567997
CDC25C	P30307	123	153	129	129	Mutagenesis	Note=Loss of phosphorylation. Severely impairs PLK1-binding. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	123	153	129	129	Mutagenesis	Note=Loss of phosphorylation. Severely impairs PLK1-binding. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	123	153	130	130	Mutagenesis	Note=Loss of phosphorylation. Severely impairs PLK1-binding. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	123	153	130	130	Mutagenesis	Note=Loss of phosphorylation. Severely impairs PLK1-binding. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12595692;Dbxref=PMID:12595692
CDC25C	P30307	153	205	191	191	Mutagenesis	Note=Facilitates nuclear exclusion. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	153	205	191	191	Mutagenesis	Note=Facilitates nuclear exclusion. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	153	205	191	191	Mutagenesis	Note=Mimicks phosphorylation state%2C leading to enhanced accumulation in the nucleus. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	153	205	191	191	Mutagenesis	Note=Mimicks phosphorylation state%2C leading to enhanced accumulation in the nucleus. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14968113;Dbxref=PMID:14968113
CDC25C	P30307	123	153	127	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BZI
CDC25C	P30307	123	153	127	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BZI
CDC25C	P30307	288	309	286	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	254	288	286	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	288	309	286	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	254	288	286	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	288	309	300	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	288	309	300	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	288	309	307	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
CDC25C	P30307	288	309	307	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP3
ABCC12	Q96J65	736	760	1	1359	Chain	ID=PRO_0000253578;Note=Multidrug resistance-associated protein 9
ABCC12	Q96J65	736	760	634	1359	Alternative sequence	ID=VSP_021087;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCC12	Q96J65	736	760	734	736	Alternative sequence	ID=VSP_021088;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11688999;Dbxref=PMID:11688999
ABCC12	Q96J65	736	760	737	760	Alternative sequence	ID=VSP_021089;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12011458;Dbxref=PMID:12011458
LAMP1	P11279	134	187	29	417	Chain	ID=PRO_0000017104;Note=Lysosome-associated membrane glycoprotein 1
LAMP1	P11279	314	371	29	417	Chain	ID=PRO_0000017104;Note=Lysosome-associated membrane glycoprotein 1
LAMP1	P11279	134	187	29	382	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP1	P11279	314	371	29	382	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP1	P11279	134	187	29	194	Region	Note=First lumenal domain
LAMP1	P11279	314	371	228	382	Region	Note=Second lumenal domain
LAMP1	P11279	134	187	165	165	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2243102,ECO:0000269|PubMed:8323299;Dbxref=PMID:2243102,PMID:8323299
LAMP1	P11279	134	187	181	181	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2243102,ECO:0000269|PubMed:8323299;Dbxref=PMID:2243102,PMID:8323299
LAMP1	P11279	314	371	322	322	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8323299;Dbxref=PMID:8323299
LAMP1	P11279	134	187	155	191	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00740,ECO:0000269|PubMed:2584229;Dbxref=PMID:2584229
LAMP1	P11279	314	371	338	375	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00740,ECO:0000269|PubMed:2584229;Dbxref=PMID:2584229
LAMP1	P11279	134	187	135	187	Alternative sequence	ID=VSP_056032;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CAMK2A	Q9UQM7	231	272	1	478	Chain	ID=PRO_0000086091;Note=Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK2A	Q9UQM7	52	72	1	478	Chain	ID=PRO_0000086091;Note=Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK2A	Q9UQM7	231	272	13	271	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CAMK2A	Q9UQM7	52	72	13	271	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CAMK2A	Q9UQM7	231	272	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11275
CAMK2A	Q9UQM7	231	272	235	235	Natural variant	ID=VAR_080585;Note=In MRD53%3B unknown pathological significance%3B no effect on protein abundance%3B no effect on autophosphorylation%3B no effect on neuronal migration. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100089;Dbxref=dbSNP:rs864309606,PMID:29100089
CAMK2A	Q9UQM7	52	72	51	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZ6
CAMK2A	Q9UQM7	231	272	236	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZ6
CAMK2A	Q9UQM7	231	272	242	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZ6
CAMK2A	Q9UQM7	231	272	256	258	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZ6
CAMK2A	Q9UQM7	231	272	262	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZ6
CAMK2A	Q9UQM7	231	272	269	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZ6
CKMT2	P17540	149	223	40	419	Chain	ID=PRO_0000016594;Note=Creatine kinase S-type%2C mitochondrial
CKMT2	P17540	149	223	40	419	Chain	ID=PRO_0000016594;Note=Creatine kinase S-type%2C mitochondrial
CKMT2	P17540	149	223	40	419	Chain	ID=PRO_0000016594;Note=Creatine kinase S-type%2C mitochondrial
CKMT2	P17540	149	223	159	401	Domain	Note=Phosphagen kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00843
CKMT2	P17540	149	223	159	401	Domain	Note=Phosphagen kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00843
CKMT2	P17540	149	223	159	401	Domain	Note=Phosphagen kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00843
CKMT2	P17540	149	223	162	166	Nucleotide binding	Note=ATP
CKMT2	P17540	149	223	162	166	Nucleotide binding	Note=ATP
CKMT2	P17540	149	223	162	166	Nucleotide binding	Note=ATP
CKMT2	P17540	149	223	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	177	179	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	177	179	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	177	179	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	182	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	182	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	182	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	210	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	210	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	210	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	215	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	215	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
CKMT2	P17540	149	223	215	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z9M
KCNC2	Q96PR1	538	593	1	638	Chain	ID=PRO_0000310416;Note=Potassium voltage-gated channel subfamily C member 2
KCNC2	Q96PR1	538	593	474	638	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNC2	Q96PR1	538	593	539	593	Alternative sequence	ID=VSP_044742;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KCNC2	Q96PR1	538	593	539	558	Alternative sequence	ID=VSP_029269;Note=In isoform 4. VLSGDDSTGSEPPLSPPERL->DNCKEVVITGYTQAEARSLT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KCNC2	Q96PR1	538	593	559	638	Alternative sequence	ID=VSP_029270;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KIF13B	Q9NQT8	1486	1507	1	1826	Chain	ID=PRO_0000125448;Note=Kinesin-like protein KIF13B
KIF13B	Q9NQT8	1310	1361	1	1826	Chain	ID=PRO_0000125448;Note=Kinesin-like protein KIF13B
KIF13B	Q9NQT8	1279	1310	1	1826	Chain	ID=PRO_0000125448;Note=Kinesin-like protein KIF13B
KIF13B	Q9NQT8	1220	1279	1	1826	Chain	ID=PRO_0000125448;Note=Kinesin-like protein KIF13B
KIF13B	Q9NQT8	871	928	1	1826	Chain	ID=PRO_0000125448;Note=Kinesin-like protein KIF13B
KIF13B	Q9NQT8	1310	1361	1	1460	Alternative sequence	ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF13B	Q9NQT8	1279	1310	1	1460	Alternative sequence	ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF13B	Q9NQT8	1220	1279	1	1460	Alternative sequence	ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF13B	Q9NQT8	871	928	1	1460	Alternative sequence	ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF13B	Q9NQT8	1486	1507	1487	1507	Alternative sequence	ID=VSP_056361;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MVK	Q03426	124	175	1	396	Chain	ID=PRO_0000156657;Note=Mevalonate kinase
MVK	Q03426	256	295	1	396	Chain	ID=PRO_0000156657;Note=Mevalonate kinase
MVK	Q03426	204	243	1	396	Chain	ID=PRO_0000156657;Note=Mevalonate kinase
MVK	Q03426	124	175	140	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17256
MVK	Q03426	204	243	204	204	Active site	Note=Proton acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:9325256;Dbxref=PMID:9325256
MVK	Q03426	124	175	146	146	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17256
MVK	Q03426	124	175	135	135	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17256
MVK	Q03426	124	175	132	132	Natural variant	ID=VAR_029520;Note=In HIDS. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895336,PMID:15536479
MVK	Q03426	124	175	135	135	Natural variant	ID=VAR_010959;Note=In HIDS. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11313768;Dbxref=dbSNP:rs104895297,PMID:11313768
MVK	Q03426	124	175	148	148	Natural variant	ID=VAR_010960;Note=In HIDS. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313768,ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895298,PMID:11313768,PMID:15536479
MVK	Q03426	124	175	150	150	Natural variant	ID=VAR_010961;Note=In HIDS. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11313769;Dbxref=dbSNP:rs747116992,PMID:11313769
MVK	Q03426	124	175	167	167	Natural variant	ID=VAR_004023;Note=In HIDS. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10369262,ECO:0000269|PubMed:11313769;Dbxref=dbSNP:rs104895300,PMID:10369262,PMID:11313769
MVK	Q03426	124	175	171	171	Natural variant	ID=VAR_029521;Note=In HIDS. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895337,PMID:15536479
MVK	Q03426	204	243	211	211	Natural variant	ID=VAR_029522;Note=In HIDS. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895325,PMID:15536479
MVK	Q03426	204	243	215	215	Natural variant	ID=VAR_010963;Note=In HIDS. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313769,ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895303,PMID:11313769,PMID:15536479
MVK	Q03426	204	243	243	243	Natural variant	ID=VAR_010964;Note=In MEVA. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10417275;Dbxref=dbSNP:rs104895314,PMID:10417275
MVK	Q03426	256	295	264	264	Natural variant	ID=VAR_010965;Note=In MEVA. L->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10417275,ECO:0000269|PubMed:11313768;Dbxref=dbSNP:rs104895315,PMID:10417275,PMID:11313768
MVK	Q03426	256	295	265	265	Natural variant	ID=VAR_010966;Note=In MEVA. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10417275;Dbxref=dbSNP:rs104895316,PMID:10417275
MVK	Q03426	256	295	265	265	Natural variant	ID=VAR_029524;Note=In HIDS. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895316,PMID:15536479
MVK	Q03426	256	295	268	268	Natural variant	ID=VAR_004024;Note=In HIDS and MEVA. I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10369261,ECO:0000269|PubMed:10369262,ECO:0000269|PubMed:10417275,ECO:0000269|PubMed:11313768,ECO:0000269|PubMed:11313769,ECO:0000269|PubMed:15536479;Dbxref=dbSNP:rs104895304,PMID:10369261,PMID:10369262,PMID:10417275,PMID:11313768,PMID:11313769,PMID:15536479
MVK	Q03426	256	295	279	279	Natural variant	ID=VAR_075039;Note=In POROK3. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22983302;Dbxref=PMID:22983302
MVK	Q03426	256	295	291	291	Natural variant	ID=VAR_075040;Note=In POROK3. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22983302;Dbxref=PMID:22983302
MVK	Q03426	124	175	149	149	Mutagenesis	Note=No effect on kinase activity. Approximately 4- and 8-fold decrease affinities for ATP and mevalonate%2C respectively. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18302342;Dbxref=PMID:18302342
MVK	Q03426	204	243	204	204	Mutagenesis	Note=No change in protein stability. Loss of kinase activity. Normal affinities for ATP and mevalonate. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9325256;Dbxref=PMID:9325256
MVK	Q03426	204	243	204	204	Mutagenesis	Note=No change in protein stability. Loss of kinase activity. Normal affinities for ATP and mevalonate. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9325256;Dbxref=PMID:9325256
MVK	Q03426	124	175	122	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	124	175	129	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	124	175	141	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	124	175	145	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	124	175	167	171	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	124	175	173	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	204	243	203	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	204	243	212	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	204	243	221	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	204	243	230	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	256	295	243	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	204	243	243	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	256	295	258	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
MVK	Q03426	256	295	288	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3V
KIF3C	O14782	630	668	1	793	Chain	ID=PRO_0000125397;Note=Kinesin-like protein KIF3C
KIF3C	O14782	630	668	1	793	Chain	ID=PRO_0000125397;Note=Kinesin-like protein KIF3C
KIF3C	O14782	630	668	630	793	Region	Note=Globular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF3C	O14782	630	668	630	793	Region	Note=Globular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF3C	O14782	630	668	630	630	Sequence conflict	Note=K->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF3C	O14782	630	668	630	630	Sequence conflict	Note=K->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF25	Q9UIL4	56	105	1	384	Chain	ID=PRO_0000125435;Note=Kinesin-like protein KIF25
KIF25	Q9UIL4	276	328	1	384	Chain	ID=PRO_0000125435;Note=Kinesin-like protein KIF25
KIF25	Q9UIL4	56	105	1	384	Chain	ID=PRO_0000125435;Note=Kinesin-like protein KIF25
KIF25	Q9UIL4	276	328	1	384	Chain	ID=PRO_0000125435;Note=Kinesin-like protein KIF25
KIF25	Q9UIL4	56	105	7	363	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF25	Q9UIL4	276	328	7	363	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF25	Q9UIL4	56	105	7	363	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF25	Q9UIL4	276	328	7	363	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF25	Q9UIL4	56	105	65	72	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF25	Q9UIL4	56	105	65	72	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF25	Q9UIL4	276	328	278	329	Alternative sequence	ID=VSP_002867;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF25	Q9UIL4	276	328	278	329	Alternative sequence	ID=VSP_002867;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
KIF5C	O60282	791	815	1	957	Chain	ID=PRO_0000125355;Note=Kinesin heavy chain isoform 5C
KIF5C	O60282	791	815	406	923	Coiled coil	.
KIF6	Q6ZMV9	727	743	1	814	Chain	ID=PRO_0000125441;Note=Kinesin-like protein KIF6
KIF6	Q6ZMV9	603	620	1	814	Chain	ID=PRO_0000125441;Note=Kinesin-like protein KIF6
KIF6	Q6ZMV9	330	359	1	814	Chain	ID=PRO_0000125441;Note=Kinesin-like protein KIF6
KIF6	Q6ZMV9	330	359	5	345	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
KIF6	Q6ZMV9	330	359	356	385	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF6	Q6ZMV9	603	620	588	683	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KIF6	Q6ZMV9	330	359	1	549	Alternative sequence	ID=VSP_014468;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KIF6	Q6ZMV9	727	743	721	814	Alternative sequence	ID=VSP_014470;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIF6	Q6ZMV9	727	743	728	744	Alternative sequence	ID=VSP_014471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TK2	O00142	28	46	1	33	Transit peptide	Note=Mitochondrion
TK2	O00142	137	167	34	265	Chain	ID=PRO_0000016842;Note=Thymidine kinase 2%2C mitochondrial
TK2	O00142	119	137	34	265	Chain	ID=PRO_0000016842;Note=Thymidine kinase 2%2C mitochondrial
TK2	O00142	94	119	34	265	Chain	ID=PRO_0000016842;Note=Thymidine kinase 2%2C mitochondrial
TK2	O00142	46	76	34	265	Chain	ID=PRO_0000016842;Note=Thymidine kinase 2%2C mitochondrial
TK2	O00142	28	46	34	265	Chain	ID=PRO_0000016842;Note=Thymidine kinase 2%2C mitochondrial
TK2	O00142	46	76	57	65	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TK2	O00142	119	137	133	133	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255
TK2	O00142	94	119	99	99	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
TK2	O00142	94	119	110	110	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
TK2	O00142	119	137	134	134	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
TK2	O00142	94	119	1	97	Alternative sequence	ID=VSP_054606;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TK2	O00142	46	76	1	97	Alternative sequence	ID=VSP_054606;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TK2	O00142	28	46	1	97	Alternative sequence	ID=VSP_054606;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TK2	O00142	28	46	1	41	Alternative sequence	ID=VSP_003028;Note=In isoform 2. MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPP->MGAFCQRPSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9079672;Dbxref=PMID:9079672
TK2	O00142	46	76	53	77	Alternative sequence	ID=VSP_043503;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TK2	O00142	94	119	78	95	Alternative sequence	ID=VSP_044459;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TK2	O00142	46	76	53	53	Natural variant	ID=VAR_019419;Note=In MTDPS2. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12391347;Dbxref=dbSNP:rs137854432,PMID:12391347
TK2	O00142	46	76	64	64	Natural variant	ID=VAR_023790;Note=In MTDPS2. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15907288;Dbxref=dbSNP:rs281865487,PMID:15907288
TK2	O00142	94	119	108	108	Natural variant	ID=VAR_019420;Note=In MTDPS2%3B reduction of activity. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391347,ECO:0000269|PubMed:15639197;Dbxref=dbSNP:rs137854431,PMID:12391347,PMID:15639197
TK2	O00142	94	119	117	117	Natural variant	ID=VAR_072789;Note=In MTDPS2%3B severe form of combined brain and muscular atrophy%3B depletion of mtDNA in skeletal muscle%3B normal residual mtDNA in blood and fibroblasts. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25446393;Dbxref=PMID:25446393
TK2	O00142	119	137	121	121	Natural variant	ID=VAR_019421;Note=In MTDPS2%3B reduction of activity in muscles. H->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11687801,ECO:0000269|PubMed:12391347;Dbxref=dbSNP:rs137854429,PMID:11687801,PMID:12391347
TK2	O00142	137	167	139	139	Natural variant	ID=VAR_072790;Note=In MTDPS2%3B severe form of combined brain and muscular atrophy%3B depletion of mtDNA in skeletal muscle%3B normal residual mtDNA in blood and fibroblasts. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25446393;Dbxref=dbSNP:rs281865494,PMID:25446393
TK2	O00142	28	46	37	37	Sequence conflict	Note=R->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
TK2	O00142	46	76	49	49	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TK2	O00142	46	76	61	61	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
KLC2	Q9H0B6	76	153	1	622	Chain	ID=PRO_0000215095;Note=Kinesin light chain 2
KLC2	Q9H0B6	76	153	1	622	Chain	ID=PRO_0000215095;Note=Kinesin light chain 2
KLC2	Q9H0B6	76	153	1	622	Chain	ID=PRO_0000215095;Note=Kinesin light chain 2
KLC2	Q9H0B6	76	153	78	143	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KLC2	Q9H0B6	76	153	78	143	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KLC2	Q9H0B6	76	153	78	143	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KLC2	Q9H0B6	76	153	151	151	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
KLC2	Q9H0B6	76	153	151	151	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
KLC2	Q9H0B6	76	153	151	151	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
KLC2	Q9H0B6	76	153	77	153	Alternative sequence	ID=VSP_043486;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC2	Q9H0B6	76	153	77	153	Alternative sequence	ID=VSP_043486;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLC2	Q9H0B6	76	153	77	153	Alternative sequence	ID=VSP_043486;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KLHL2	O95198	412	446	1	593	Chain	ID=PRO_0000119101;Note=Kelch-like protein 2
KLHL2	O95198	412	446	402	447	Repeat	Note=Kelch 3
KLHL2	O95198	412	446	410	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHB
KLHL2	O95198	412	446	417	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHB
KLHL2	O95198	412	446	422	425	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHB
KLHL2	O95198	412	446	426	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHB
KLHL2	O95198	412	446	441	445	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHB
KLHL3	Q9UH77	406	440	1	587	Chain	ID=PRO_0000119103;Note=Kelch-like protein 3
KLHL3	Q9UH77	5	44	1	587	Chain	ID=PRO_0000119103;Note=Kelch-like protein 3
KLHL3	Q9UH77	406	440	396	441	Repeat	Note=Kelch 3
KLHL3	Q9UH77	5	44	10	10	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26435498;Dbxref=PMID:26435498
KLHL3	Q9UH77	406	440	433	433	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26435498,ECO:0000269|PubMed:27727489;Dbxref=PMID:26435498,PMID:27727489
KLHL3	Q9UH77	5	44	1	82	Alternative sequence	ID=VSP_002817;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10843806;Dbxref=PMID:10843806
KLHL3	Q9UH77	5	44	1	32	Alternative sequence	ID=VSP_002816;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10843806;Dbxref=PMID:10843806
KLHL3	Q9UH77	406	440	410	410	Natural variant	ID=VAR_067516;Note=In PHA2D%3B impaired interaction with WNK1. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22266938,ECO:0000269|PubMed:22406640,ECO:0000269|PubMed:23387299;Dbxref=dbSNP:rs199469641,PMID:22266938,PMID:22406640,PMID:23387299
KLHL3	Q9UH77	406	440	426	426	Natural variant	ID=VAR_067517;Note=In PHA2D. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22406640;Dbxref=dbSNP:rs387907156,PMID:22406640
KLHL3	Q9UH77	406	440	427	427	Natural variant	ID=VAR_067518;Note=In PHA2D. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22266938;Dbxref=dbSNP:rs199469642,PMID:22266938
KLHL3	Q9UH77	406	440	431	431	Natural variant	ID=VAR_067519;Note=In PHA2D. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22266938;Dbxref=dbSNP:rs199469643,PMID:22266938
KLHL3	Q9UH77	406	440	432	432	Natural variant	ID=VAR_067520;Note=In PHA2D%3B impaired interaction with WNK1. S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22266938,ECO:0000269|PubMed:22406640,ECO:0000269|PubMed:23387299;Dbxref=dbSNP:rs199469631,PMID:22266938,PMID:22406640,PMID:23387299
KLHL3	Q9UH77	406	440	433	433	Natural variant	ID=VAR_067521;Note=In PHA2D%3B decreased interaction with WNK4. S->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22406640,ECO:0000269|PubMed:26435498;Dbxref=PMID:22406640,PMID:26435498
KLHL3	Q9UH77	406	440	433	433	Natural variant	ID=VAR_067522;Note=In PHA2D. S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22266938,ECO:0000269|PubMed:23387299;Dbxref=dbSNP:rs199469632,PMID:22266938,PMID:23387299
KLHL3	Q9UH77	406	440	438	438	Natural variant	ID=VAR_067523;Note=Found in a patient with hypertension%3B unknown pathological significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22266938;Dbxref=dbSNP:rs907779058,PMID:22266938
KLHL3	Q9UH77	406	440	433	433	Mutagenesis	Note=Phosphomimetic mutant that shows decreased interaction with WNK4. S->E%2CD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26435498;Dbxref=PMID:26435498
KLHL3	Q9UH77	406	440	404	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CH9
KLHL3	Q9UH77	406	440	411	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CH9
KLHL3	Q9UH77	406	440	416	419	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CH9
KLHL3	Q9UH77	406	440	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CH9
KLHL3	Q9UH77	406	440	435	439	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CH9
KMO	O15229	205	229	1	486	Chain	ID=PRO_0000229742;Note=Kynurenine 3-monooxygenase;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMO	O15229	366	400	1	486	Chain	ID=PRO_0000229742;Note=Kynurenine 3-monooxygenase;Ontology_term=ECO:0000305;evidence=ECO:0000305
KMO	O15229	366	400	385	404	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03018
KMO	O15229	366	400	398	398	Binding site	Note=L-kynurenine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q84HF5
KMO	O15229	366	400	367	400	Alternative sequence	ID=VSP_051972;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16710414;Dbxref=PMID:16710414
KMO	O15229	366	400	367	379	Alternative sequence	ID=VSP_051973;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16710414;Dbxref=PMID:16710414
KMO	O15229	366	400	366	366	Mutagenesis	Note=Strongly decreases kynurenine 3-monooxygenase activity. E->A%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29208702;Dbxref=PMID:29208702
KMO	O15229	366	400	367	367	Mutagenesis	Note=Strongly decreases kynurenine 3-monooxygenase activity. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29208702;Dbxref=PMID:29208702
KMO	O15229	366	400	367	367	Mutagenesis	Note=Strongly decreases kynurenine 3-monooxygenase activity. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29208702;Dbxref=PMID:29208702
KMO	O15229	366	400	398	398	Mutagenesis	Note=Abolishes kynurenine 3-monooxygenase activity. Y->A%2CF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29208702;Dbxref=PMID:29208702
KMO	O15229	205	229	202	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X68
KMO	O15229	205	229	212	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X68
KMO	O15229	205	229	222	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X68
PRKCI	P41743	74	104	2	596	Chain	ID=PRO_0000055710;Note=Protein kinase C iota type
PRKCI	P41743	235	294	2	596	Chain	ID=PRO_0000055710;Note=Protein kinase C iota type
PRKCI	P41743	430	472	2	596	Chain	ID=PRO_0000055710;Note=Protein kinase C iota type
PRKCI	P41743	499	529	2	596	Chain	ID=PRO_0000055710;Note=Protein kinase C iota type
PRKCI	P41743	74	104	25	108	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
PRKCI	P41743	235	294	254	522	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCI	P41743	430	472	254	522	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCI	P41743	499	529	254	522	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCI	P41743	499	529	523	594	Domain	Note=AGC-kinase C-terminal
PRKCI	P41743	235	294	260	268	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCI	P41743	74	104	2	253	Region	Note=Regulatory domain
PRKCI	P41743	235	294	2	253	Region	Note=Regulatory domain
PRKCI	P41743	74	104	72	91	Region	Note=Interaction with PARD6A
PRKCI	P41743	235	294	283	283	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKCI	P41743	235	294	265	265	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11713277,ECO:0000269|PubMed:11891849;Dbxref=PMID:11713277,PMID:11891849
PRKCI	P41743	235	294	280	280	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11713277;Dbxref=PMID:11713277
PRKCI	P41743	74	104	85	85	Mutagenesis	Note=Slight decrease of interaction with PARD6A. Loss of interaction with PARD6A%3B when associated with A-91. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15590654;Dbxref=PMID:15590654
PRKCI	P41743	74	104	91	91	Mutagenesis	Note=Slight decrease of interaction with PARD6A. Loss of interaction with PARD6A%3B when associated with A-85. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15590654;Dbxref=PMID:15590654
PRKCI	P41743	235	294	265	265	Mutagenesis	Note=No effect on the SRC-mediated phosphorylation state. No effect on SRC-induced enzyme activity. Little effect on TRAF6-mediated activation of NF-kappa-B. Decreased binding to KPNB1/importin-beta. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11713277,ECO:0000269|PubMed:11891849;Dbxref=PMID:11713277,PMID:11891849
PRKCI	P41743	235	294	274	274	Mutagenesis	Note=No effect on activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10906326;Dbxref=PMID:10906326
PRKCI	P41743	235	294	274	274	Mutagenesis	Note=Abolishes activity. K->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10906326;Dbxref=PMID:10906326
PRKCI	P41743	235	294	280	280	Mutagenesis	Note=No effect on the SRC-mediated phosphorylation state. No effect on SRC-induced enzyme activity. No effect on TRAF6-mediated activation of NF-kappa-B. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11713277;Dbxref=PMID:11713277
PRKCI	P41743	499	529	508	508	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRKCI	P41743	74	104	73	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VD2
PRKCI	P41743	74	104	77	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WMH
PRKCI	P41743	74	104	83	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WMH
PRKCI	P41743	74	104	101	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WMH
PRKCI	P41743	235	294	251	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	235	294	254	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	235	294	264	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	235	294	274	277	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A8X
PRKCI	P41743	235	294	279	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	235	294	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	235	294	293	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	430	472	433	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	430	472	452	457	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A8X
PRKCI	P41743	430	472	467	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	499	529	501	503	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	499	529	505	507	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZRZ
PRKCI	P41743	499	529	509	511	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	499	529	512	517	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	499	529	520	522	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
PRKCI	P41743	499	529	527	531	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LI9
MPV17	P39210	125	136	1	176	Chain	ID=PRO_0000218927;Note=Protein Mpv17
MPV17	P39210	93	125	1	176	Chain	ID=PRO_0000218927;Note=Protein Mpv17
MPV17	P39210	125	136	1	176	Chain	ID=PRO_0000218927;Note=Protein Mpv17
MPV17	P39210	93	125	1	176	Chain	ID=PRO_0000218927;Note=Protein Mpv17
MPV17	P39210	93	125	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MPV17	P39210	93	125	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MPV17	P39210	125	136	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MPV17	P39210	125	136	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MPV17	P39210	93	125	94	94	Natural variant	ID=VAR_076202;Note=In MTDPS6. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20074988;Dbxref=dbSNP:rs267607257,PMID:20074988
MPV17	P39210	93	125	94	94	Natural variant	ID=VAR_076202;Note=In MTDPS6. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20074988;Dbxref=dbSNP:rs267607257,PMID:20074988
MPV17	P39210	93	125	98	98	Natural variant	ID=VAR_076203;Note=In MTDPS6. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20074988,ECO:0000269|PubMed:26741492;Dbxref=dbSNP:rs267607258,PMID:20074988,PMID:26741492
MPV17	P39210	93	125	98	98	Natural variant	ID=VAR_076203;Note=In MTDPS6. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20074988,ECO:0000269|PubMed:26741492;Dbxref=dbSNP:rs267607258,PMID:20074988,PMID:26741492
LAD1	O00515	491	516	1	517	Chain	ID=PRO_0000084349;Note=Ladinin-1
LAD1	O00515	462	491	1	517	Chain	ID=PRO_0000084349;Note=Ladinin-1
LAD1	O00515	416	462	1	517	Chain	ID=PRO_0000084349;Note=Ladinin-1
LAD1	O00515	342	377	1	517	Chain	ID=PRO_0000084349;Note=Ladinin-1
LAD1	O00515	13	60	1	517	Chain	ID=PRO_0000084349;Note=Ladinin-1
LAD1	O00515	13	60	28	35	Compositional bias	Note=Poly-Arg
LAD1	O00515	13	60	38	38	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
LAD1	O00515	342	377	347	347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P57016
LAD1	O00515	342	377	356	356	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
LAD1	O00515	416	462	424	424	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
LAD1	O00515	462	491	485	485	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
LAD1	O00515	13	60	56	56	Natural variant	ID=VAR_046539;Note=A->S;Dbxref=dbSNP:rs3738281
LAD1	O00515	491	516	503	503	Natural variant	ID=VAR_046544;Note=T->S;Dbxref=dbSNP:rs2275866
LRRC37A3	O60309	1568	1603	36	1634	Chain	ID=PRO_0000076244;Note=Leucine-rich repeat-containing protein 37A3
LRRC37A3	O60309	918	941	36	1634	Chain	ID=PRO_0000076244;Note=Leucine-rich repeat-containing protein 37A3
LRRC37A3	O60309	894	917	36	1634	Chain	ID=PRO_0000076244;Note=Leucine-rich repeat-containing protein 37A3
LRRC37A3	O60309	1568	1603	36	1634	Chain	ID=PRO_0000076244;Note=Leucine-rich repeat-containing protein 37A3
LRRC37A3	O60309	918	941	36	1634	Chain	ID=PRO_0000076244;Note=Leucine-rich repeat-containing protein 37A3
LRRC37A3	O60309	894	917	36	1634	Chain	ID=PRO_0000076244;Note=Leucine-rich repeat-containing protein 37A3
LRRC37A3	O60309	1568	1603	36	1581	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	918	941	36	1581	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	894	917	36	1581	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	1568	1603	36	1581	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	918	941	36	1581	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	894	917	36	1581	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	1568	1603	1582	1602	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	1568	1603	1582	1602	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	1568	1603	1603	1634	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	1568	1603	1603	1634	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A3	O60309	894	917	888	911	Repeat	Note=LRR 5
LRRC37A3	O60309	894	917	888	911	Repeat	Note=LRR 5
LRRC37A3	O60309	918	941	912	935	Repeat	Note=LRR 6
LRRC37A3	O60309	894	917	912	935	Repeat	Note=LRR 6
LRRC37A3	O60309	918	941	912	935	Repeat	Note=LRR 6
LRRC37A3	O60309	894	917	912	935	Repeat	Note=LRR 6
LRRC37A3	O60309	918	941	937	959	Repeat	Note=LRR 7
LRRC37A3	O60309	918	941	937	959	Repeat	Note=LRR 7
LRRC37A3	O60309	1568	1603	1590	1590	Natural variant	ID=VAR_061672;Note=G->A;Dbxref=dbSNP:rs28532307
LRRC37A3	O60309	1568	1603	1590	1590	Natural variant	ID=VAR_061672;Note=G->A;Dbxref=dbSNP:rs28532307
LAMB4	A4D0S4	1606	1664	20	1761	Chain	ID=PRO_0000312857;Note=Laminin subunit beta-4
LAMB4	A4D0S4	1606	1664	20	1761	Chain	ID=PRO_0000312857;Note=Laminin subunit beta-4
LAMB4	A4D0S4	1606	1664	1409	1761	Region	Note=Domain I
LAMB4	A4D0S4	1606	1664	1409	1761	Region	Note=Domain I
LAMB4	A4D0S4	1606	1664	1525	1759	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB4	A4D0S4	1606	1664	1525	1759	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB4	A4D0S4	1606	1664	1609	1609	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB4	A4D0S4	1606	1664	1609	1609	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB4	A4D0S4	1606	1664	773	1761	Alternative sequence	ID=VSP_029914;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMB4	A4D0S4	1606	1664	773	1761	Alternative sequence	ID=VSP_029914;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMB4	A4D0S4	1606	1664	1612	1612	Natural variant	ID=VAR_037594;Note=R->S;Dbxref=dbSNP:rs2528693
LAMB4	A4D0S4	1606	1664	1612	1612	Natural variant	ID=VAR_037594;Note=R->S;Dbxref=dbSNP:rs2528693
LAMP5	Q9UJQ1	79	123	30	280	Chain	ID=PRO_0000021031;Note=Lysosome-associated membrane glycoprotein 5
LAMP5	Q9UJQ1	158	221	30	280	Chain	ID=PRO_0000021031;Note=Lysosome-associated membrane glycoprotein 5
LAMP5	Q9UJQ1	79	123	30	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP5	Q9UJQ1	158	221	30	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMP5	Q9UJQ1	79	123	80	123	Alternative sequence	ID=VSP_037186;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LAMP5	Q9UJQ1	79	123	81	81	Natural variant	ID=VAR_014402;Note=I->V;Dbxref=dbSNP:rs2232263
LAMP5	Q9UJQ1	79	123	103	103	Natural variant	ID=VAR_014403;Note=Q->E;Dbxref=dbSNP:rs2232264
LAMP5	Q9UJQ1	158	221	158	158	Natural variant	ID=VAR_014404;Note=S->G;Dbxref=dbSNP:rs2232266
LHFPL1	Q86WI0	127	160	21	220	Chain	ID=PRO_0000244760;Note=LHFPL tetraspan subfamily member 1 protein
LHFPL1	Q86WI0	127	160	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LHFPL1	Q86WI0	127	160	153	153	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LHFPL1	Q86WI0	127	160	1	179	Alternative sequence	ID=VSP_019616;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LHFPL1	Q86WI0	127	160	129	161	Alternative sequence	ID=VSP_019617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIPA	P38571	298	322	24	399	Chain	ID=PRO_0000017799;Note=Lysosomal acid lipase/cholesteryl ester hydrolase
LIPA	P38571	274	298	24	399	Chain	ID=PRO_0000017799;Note=Lysosomal acid lipase/cholesteryl ester hydrolase
LIPA	P38571	298	322	80	380	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPA	P38571	274	298	80	380	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPA	P38571	298	322	321	321	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
PPFIA4	O75335	355	422	1	1185	Chain	ID=PRO_0000191032;Note=Liprin-alpha-4
PPFIA4	O75335	355	422	165	499	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPFIA4	O75335	355	422	1	510	Alternative sequence	ID=VSP_053668;Note=In isoform 1 and isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9624153;Dbxref=PMID:10048485,PMID:14702039,PMID:15489334,PMID:9624153
LIN52	Q52LA3	70	98	1	116	Chain	ID=PRO_0000252154;Note=Protein lin-52 homolog
LIN7A	O14910	161	234	1	233	Chain	ID=PRO_0000189623;Note=Protein lin-7 homolog A
LIN7A	O14910	91	161	1	233	Chain	ID=PRO_0000189623;Note=Protein lin-7 homolog A
LIN7A	O14910	161	234	108	190	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
LIN7A	O14910	91	161	108	190	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
LIN7A	O14910	161	234	210	213	Compositional bias	Note=Poly-Gln
LIN7A	O14910	161	234	217	229	Compositional bias	Note=Poly-Gln
LIN7A	O14910	91	161	157	157	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAFAH1B1	P43034	300	334	1	410	Chain	ID=PRO_0000051061;Note=Platelet-activating factor acetylhydrolase IB subunit alpha
PAFAH1B1	P43034	300	334	274	333	Repeat	Note=WD 5
PAFAH1B1	P43034	300	334	83	410	Region	Note=Interaction with dynein and dynactin
PAFAH1B1	P43034	300	334	238	410	Alternative sequence	ID=VSP_019379;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PAFAH1B1	P43034	300	334	317	317	Natural variant	ID=VAR_015400;Note=In LIS1%3B reduces neuronal migration in vitro. D->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11502906,ECO:0000269|PubMed:15173193;Dbxref=dbSNP:rs121434485,PMID:11502906,PMID:15173193
LMBR1L	Q6UX01	413	467	1	489	Chain	ID=PRO_0000053910;Note=Protein LMBR1L
LMBR1L	Q6UX01	310	336	1	489	Chain	ID=PRO_0000053910;Note=Protein LMBR1L
LMBR1L	Q6UX01	310	336	306	326	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1L	Q6UX01	310	336	327	350	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1L	Q6UX01	413	467	410	431	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1L	Q6UX01	413	467	432	452	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1L	Q6UX01	413	467	453	489	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMBR1L	Q6UX01	310	336	336	355	Alternative sequence	ID=VSP_016894;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LMBR1L	Q6UX01	413	467	394	489	Alternative sequence	ID=VSP_016896;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574461;Dbxref=PMID:10574461
LMBR1L	Q6UX01	310	336	334	334	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
LMF1	Q96S06	243	299	1	567	Chain	ID=PRO_0000276739;Note=Lipase maturation factor 1
LMF1	Q96S06	243	299	222	292	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMF1	Q96S06	243	299	293	321	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	584	607	28	947	Chain	ID=PRO_0000232653;Note=Leucine-rich repeat-containing protein 37B
LRRC37B	Q96QE4	892	927	28	947	Chain	ID=PRO_0000232653;Note=Leucine-rich repeat-containing protein 37B
LRRC37B	Q96QE4	584	607	28	947	Chain	ID=PRO_0000232653;Note=Leucine-rich repeat-containing protein 37B
LRRC37B	Q96QE4	841	876	28	947	Chain	ID=PRO_0000232653;Note=Leucine-rich repeat-containing protein 37B
LRRC37B	Q96QE4	584	607	28	905	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	892	927	28	905	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	584	607	28	905	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	841	876	28	905	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	892	927	906	926	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	892	927	927	947	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	584	607	580	601	Repeat	Note=LRR 2
LRRC37B	Q96QE4	584	607	580	601	Repeat	Note=LRR 2
LRRC37B	Q96QE4	584	607	604	625	Repeat	Note=LRR 3
LRRC37B	Q96QE4	584	607	604	625	Repeat	Note=LRR 3
LRRC37B	Q96QE4	892	927	867	897	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	841	876	867	897	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37B	Q96QE4	584	607	604	604	Sequence conflict	Note=Y->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRRC37B	Q96QE4	584	607	604	604	Sequence conflict	Note=Y->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRRC42	Q9Y546	158	201	1	428	Chain	ID=PRO_0000223622;Note=Leucine-rich repeat-containing protein 42
LRRC42	Q9Y546	158	201	1	428	Chain	ID=PRO_0000223622;Note=Leucine-rich repeat-containing protein 42
LRRC42	Q9Y546	158	201	149	170	Repeat	Note=LRR 1
LRRC42	Q9Y546	158	201	149	170	Repeat	Note=LRR 1
LRRC42	Q9Y546	158	201	174	195	Repeat	Note=LRR 2
LRRC42	Q9Y546	158	201	174	195	Repeat	Note=LRR 2
LRRC28	Q86X40	128	197	1	367	Chain	ID=PRO_0000272298;Note=Leucine-rich repeat-containing protein 28
LRRC28	Q86X40	128	197	112	133	Repeat	Note=LRR 5
LRRC28	Q86X40	128	197	135	156	Repeat	Note=LRR 6
LRRC28	Q86X40	128	197	158	180	Repeat	Note=LRR 7
LRRC28	Q86X40	128	197	181	202	Repeat	Note=LRR 8
LRRC28	Q86X40	128	197	1	128	Alternative sequence	ID=VSP_022395;Note=In isoform 3. MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP->MFMGIVAATDFIWLNCYNIDSFCLFQFIRMQFILILILVV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LRRC28	Q86X40	128	197	168	168	Natural variant	ID=VAR_034084;Note=R->H;Dbxref=dbSNP:rs11857384
LRIG2	O94898	492	599	41	1065	Chain	ID=PRO_0000014829;Note=Leucine-rich repeats and immunoglobulin-like domains protein 2
LRIG2	O94898	843	893	41	1065	Chain	ID=PRO_0000014829;Note=Leucine-rich repeats and immunoglobulin-like domains protein 2
LRIG2	O94898	893	990	41	1065	Chain	ID=PRO_0000014829;Note=Leucine-rich repeats and immunoglobulin-like domains protein 2
LRIG2	O94898	492	599	41	807	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRIG2	O94898	843	893	829	1065	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRIG2	O94898	893	990	829	1065	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRIG2	O94898	492	599	443	494	Domain	Note=LRRCT
LRIG2	O94898	492	599	498	597	Domain	Note=Ig-like C2-type 1
LRIG2	O94898	893	990	906	906	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q52KR2
LRIG2	O94898	492	599	514	514	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRIG2	O94898	492	599	571	571	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRIG2	O94898	492	599	589	589	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRIG2	O94898	492	599	519	580	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
LRRFIP1	Q32MZ4	66	83	2	808	Chain	ID=PRO_0000248392;Note=Leucine-rich repeat flightless-interacting protein 1
LRRFIP1	Q32MZ4	137	161	2	808	Chain	ID=PRO_0000248392;Note=Leucine-rich repeat flightless-interacting protein 1
LRRFIP1	Q32MZ4	137	161	128	250	Coiled coil	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23099021;Dbxref=PMID:23099021
LRRFIP1	Q32MZ4	66	83	52	83	Alternative sequence	ID=VSP_020264;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9705290;Dbxref=PMID:15489334,PMID:9705290
LRRFIP1	Q32MZ4	66	83	83	83	Alternative sequence	ID=VSP_046811;Note=In isoform 4. R->RSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10366446;Dbxref=PMID:10366446
LRRFIP1	Q32MZ4	137	161	137	160	Alternative sequence	ID=VSP_020265;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9671805,ECO:0000303|PubMed:9705290;Dbxref=PMID:15489334,PMID:9671805,PMID:9705290
LRRFIP1	Q32MZ4	66	83	68	68	Natural variant	ID=VAR_036037;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ALOX12B	O75342	309	357	1	701	Chain	ID=PRO_0000220689;Note=Arachidonate 12-lipoxygenase%2C 12R-type
ALOX12B	O75342	309	357	120	701	Domain	Note=Lipoxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726
ALOX12B	O75342	309	357	318	318	Natural variant	ID=VAR_069550;Note=In ARCI2. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=PMID:16116617
LY9	Q9HBG7	357	447	48	655	Chain	ID=PRO_0000014851;Note=T-lymphocyte surface antigen Ly-9
LY9	Q9HBG7	610	633	48	655	Chain	ID=PRO_0000014851;Note=T-lymphocyte surface antigen Ly-9
LY9	Q9HBG7	357	447	48	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LY9	Q9HBG7	610	633	477	655	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LY9	Q9HBG7	357	447	251	363	Domain	Note=Ig-like V-type 2
LY9	Q9HBG7	357	447	364	452	Domain	Note=Ig-like C2-type 2
LY9	Q9HBG7	610	633	624	629	Motif	Note=ITSM 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13291
LY9	Q9HBG7	357	447	413	413	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LY9	Q9HBG7	357	447	424	424	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LY9	Q9HBG7	357	447	377	446	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
LY9	Q9HBG7	357	447	383	427	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
LY9	Q9HBG7	357	447	359	448	Alternative sequence	ID=VSP_002524;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
LYPLA1	O75608	120	154	1	230	Chain	ID=PRO_0000102267;Note=Acyl-protein thioesterase 1
LYPLA1	O75608	56	71	1	230	Chain	ID=PRO_0000102267;Note=Acyl-protein thioesterase 1
LYPLA1	O75608	34	55	1	230	Chain	ID=PRO_0000102267;Note=Acyl-protein thioesterase 1
LYPLA1	O75608	56	71	57	72	Alternative sequence	ID=VSP_009196;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11042152;Dbxref=PMID:11042152
LYPLA1	O75608	120	154	153	153	Natural variant	ID=VAR_060991;Note=P->S;Dbxref=dbSNP:rs11549448
LYPLA1	O75608	120	154	127	131	Sequence conflict	Note=YTALT->SLIRG;Ontology_term=ECO:0000305;evidence=ECO:0000305
LYPLA1	O75608	34	55	34	42	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	34	55	49	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	56	71	58	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	56	71	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	56	71	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	120	154	120	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	120	154	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYPLA1	O75608	120	154	149	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FJ2
LYN	P07948	95	127	2	512	Chain	ID=PRO_0000088129;Note=Tyrosine-protein kinase Lyn
LYN	P07948	263	324	2	512	Chain	ID=PRO_0000088129;Note=Tyrosine-protein kinase Lyn
LYN	P07948	95	127	63	123	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
LYN	P07948	263	324	247	501	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LYN	P07948	263	324	275	275	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
LYN	P07948	263	324	306	306	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
LYN	P07948	263	324	316	316	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
LYN	P07948	263	324	275	275	Mutagenesis	Note=Loss of activity and no effect on localization to the cell membrane. Abundant localization in the nucleus%3B when associated with A-2 and A-3. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11435302,ECO:0000269|PubMed:11517336,ECO:0000269|PubMed:15173188,ECO:0000269|PubMed:18817770;Dbxref=PMID:11435302,PMID:11517336,PMID:15173188,PMID:18817770
LYN	P07948	263	324	275	275	Mutagenesis	Note=Loss of kinase activity. K->L%2CR;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11435302,ECO:0000269|PubMed:11517336,ECO:0000269|PubMed:15173188,ECO:0000269|PubMed:18817770;Dbxref=PMID:11435302,PMID:11517336,PMID:15173188,PMID:18817770
LYN	P07948	95	127	89	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1F
LYN	P07948	95	127	97	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1F
LYN	P07948	95	127	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1F
LYN	P07948	95	127	110	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1F
LYN	P07948	95	127	115	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1F
LYN	P07948	95	127	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1F
LYN	P07948	263	324	260	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XY1
LYN	P07948	263	324	267	269	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XY1
LYN	P07948	263	324	270	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XY1
LYN	P07948	263	324	284	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XY1
LYN	P07948	263	324	305	309	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XY1
LYN	P07948	263	324	311	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XY1
MAP3K10	Q02779	612	847	1	954	Chain	ID=PRO_0000086259;Note=Mitogen-activated protein kinase kinase kinase 10
MAP3K10	Q02779	612	847	807	807	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K10	Q02779	612	847	818	818	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MS4A4A	Q96JQ5	67	110	1	239	Chain	ID=PRO_0000158634;Note=Membrane-spanning 4-domains subfamily A member 4A
MS4A4A	Q96JQ5	129	182	1	239	Chain	ID=PRO_0000158634;Note=Membrane-spanning 4-domains subfamily A member 4A
MS4A4A	Q96JQ5	182	216	1	239	Chain	ID=PRO_0000158634;Note=Membrane-spanning 4-domains subfamily A member 4A
MS4A4A	Q96JQ5	67	110	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	67	110	86	98	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	67	110	99	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	129	182	120	137	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	129	182	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	129	182	159	179	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	129	182	180	200	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	182	216	180	200	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	182	216	201	239	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4A	Q96JQ5	129	182	130	182	Alternative sequence	ID=VSP_007380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11486273;Dbxref=PMID:11486273
MS4A4A	Q96JQ5	182	216	130	182	Alternative sequence	ID=VSP_007380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11486273;Dbxref=PMID:11486273
MS4A4A	Q96JQ5	129	182	178	178	Natural variant	ID=VAR_024540;Note=M->V;Dbxref=dbSNP:rs6591561
MS4A4A	Q96JQ5	182	216	191	191	Natural variant	ID=VAR_062123;Note=L->I;Dbxref=dbSNP:rs4644658
MS4A4A	Q96JQ5	67	110	100	100	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
MS4A4A	Q96JQ5	182	216	200	200	Sequence conflict	Note=V->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
MS4A4E	Q96PG1	48	91	1	132	Chain	ID=PRO_0000158636;Note=Putative membrane-spanning 4-domains subfamily A member 4E
MS4A4E	Q96PG1	48	91	1	132	Chain	ID=PRO_0000158636;Note=Putative membrane-spanning 4-domains subfamily A member 4E
MS4A4E	Q96PG1	48	91	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4E	Q96PG1	48	91	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4E	Q96PG1	48	91	76	96	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4E	Q96PG1	48	91	76	96	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A4E	Q96PG1	48	91	49	91	Alternative sequence	ID=VSP_033858;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MS4A4E	Q96PG1	48	91	49	91	Alternative sequence	ID=VSP_033858;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MS4A4E	Q96PG1	48	91	50	132	Alternative sequence	ID=VSP_033859;Note=In isoform 3. VRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMYPYQLQQELEQQKVWNYLKNLSWRIMGSYLCFGERSELKPL->LCGHKFSTHSVSLSVAAGIRTTKGLELSEEFKLENNGIIFVFWREIRVETTIRRQVRRLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MS4A4E	Q96PG1	48	91	50	132	Alternative sequence	ID=VSP_033859;Note=In isoform 3. VRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMYPYQLQQELEQQKVWNYLKNLSWRIMGSYLCFGERSELKPL->LCGHKFSTHSVSLSVAAGIRTTKGLELSEEFKLENNGIIFVFWREIRVETTIRRQVRRLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MAN2B1	O00754	722	755	50	1011	Chain	ID=PRO_0000012069;Note=Lysosomal alpha-mannosidase
MAN2B1	O00754	303	342	50	1011	Chain	ID=PRO_0000012069;Note=Lysosomal alpha-mannosidase
MAN2B1	O00754	303	342	50	345	Chain	ID=PRO_0000012070;Note=Lysosomal alpha-mannosidase A peptide
MAN2B1	O00754	722	755	602	882	Chain	ID=PRO_0000012073;Note=Lysosomal alpha-mannosidase D peptide
MAN2B1	O00754	303	342	310	310	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAN2B1	O00754	303	342	55	358	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MAN2B1	O00754	303	342	312	312	Natural variant	ID=VAR_003340;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22161967,ECO:0000269|PubMed:9915946;Dbxref=dbSNP:rs1054487,PMID:22161967,PMID:9915946
MAN2B1	O00754	303	342	318	318	Natural variant	ID=VAR_068046;Note=In MANSA%3B reduced enzyme activity. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161967;Dbxref=dbSNP:rs774034389,PMID:22161967
MAN2B1	O00754	303	342	337	337	Natural variant	ID=VAR_003341;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22161967,ECO:0000269|PubMed:9915946;Dbxref=dbSNP:rs1133330,PMID:22161967,PMID:9915946
MAN2B1	O00754	303	342	339	342	Natural variant	ID=VAR_068047;Note=In MANSA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161967;Dbxref=PMID:22161967
MAN2B1	O00754	722	755	745	745	Natural variant	ID=VAR_068059;Note=In MANSA%3B results in less than 20%25 of wild-type enzyme activity. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161967;Dbxref=dbSNP:rs864621987,PMID:22161967
MAN2B1	O00754	722	755	750	750	Natural variant	ID=VAR_003347;Note=In MANSA%3B type II. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9758606;Dbxref=dbSNP:rs80338680,PMID:9758606
MAP4K3	Q8IVH8	769	792	1	894	Chain	ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3	Q8IVH8	529	543	1	894	Chain	ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3	Q8IVH8	352	373	1	894	Chain	ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3	Q8IVH8	269	306	1	894	Chain	ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3	Q8IVH8	122	138	1	894	Chain	ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3	Q8IVH8	269	306	16	273	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K3	Q8IVH8	122	138	16	273	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K3	Q8IVH8	769	792	556	867	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MAP4K3	Q8IVH8	122	138	136	136	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K3	Q8IVH8	352	373	352	372	Alternative sequence	ID=VSP_007053;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4K3	Q8IVH8	122	138	110	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T
MAP4K3	Q8IVH8	269	306	271	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T
MAP4K3	Q8IVH8	269	306	280	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T
MAN1B1	Q9UKM7	243	305	1	699	Chain	ID=PRO_0000210314;Note=Endoplasmic reticulum mannosyl-oligosaccharide 1%2C2-alpha-mannosidase
MAN1B1	Q9UKM7	243	305	106	699	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAN1B1	Q9UKM7	243	305	244	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FO3
MAN1B1	Q9UKM7	243	305	248	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAN1B1	Q9UKM7	243	305	271	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAN1B1	Q9UKM7	243	305	276	279	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAN1B1	Q9UKM7	243	305	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAN1B1	Q9UKM7	243	305	284	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAN1B1	Q9UKM7	243	305	289	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAN1B1	Q9UKM7	243	305	304	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9D
MAK	P20794	532	572	1	623	Chain	ID=PRO_0000086284;Note=Serine/threonine-protein kinase MAK
MAK	P20794	532	572	1	623	Chain	ID=PRO_0000086284;Note=Serine/threonine-protein kinase MAK
MAK	P20794	532	572	532	532	Alternative sequence	ID=VSP_042470;Note=In isoform 2. A->AEESIIKPIEKLSCNETFPEKLEDPQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:21825139,ECO:0000303|PubMed:21835304;Dbxref=PMID:21825139,PMID:21835304
MAK	P20794	532	572	532	532	Alternative sequence	ID=VSP_042470;Note=In isoform 2. A->AEESIIKPIEKLSCNETFPEKLEDPQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:21825139,ECO:0000303|PubMed:21835304;Dbxref=PMID:21825139,PMID:21835304
MAK	P20794	532	572	533	572	Alternative sequence	ID=VSP_042471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21697133;Dbxref=PMID:21697133
MAK	P20794	532	572	533	572	Alternative sequence	ID=VSP_042471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21697133;Dbxref=PMID:21697133
MAK	P20794	532	572	550	550	Natural variant	ID=VAR_042010;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56217305,PMID:17344846
MAK	P20794	532	572	550	550	Natural variant	ID=VAR_042010;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56217305,PMID:17344846
MYL9	P24844	61	115	2	172	Chain	ID=PRO_0000198735;Note=Myosin regulatory light polypeptide 9
MYL9	P24844	61	115	29	64	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL9	P24844	61	115	98	133	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL9	P24844	61	115	62	115	Alternative sequence	ID=VSP_042834;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
MYL9	P24844	61	115	81	81	Sequence conflict	Note=I->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL9	P24844	61	115	114	114	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYLIP	Q8WY64	221	275	1	445	Chain	ID=PRO_0000055972;Note=E3 ubiquitin-protein ligase MYLIP
MYLIP	Q8WY64	221	275	1	279	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MYLIP	Q8WY64	221	275	265	265	Mutagenesis	Note=Unable to clear LDLR from the plasma membrane. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22109552;Dbxref=PMID:22109552
MYLIP	Q8WY64	221	275	269	269	Mutagenesis	Note=Unable to clear LDLR from the plasma membrane. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22109552;Dbxref=PMID:22109552
MYLIP	Q8WY64	221	275	262	263	Sequence conflict	Note=SG->TR;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO1F	O00160	423	452	1	1098	Chain	ID=PRO_0000123452;Note=Unconventional myosin-If
MYO1F	O00160	423	452	17	690	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO6	Q9UM54	217	272	1	1294	Chain	ID=PRO_0000123464;Note=Unconventional myosin-VI
MYO6	Q9UM54	272	299	1	1294	Chain	ID=PRO_0000123464;Note=Unconventional myosin-VI
MYO6	Q9UM54	1036	1045	1	1294	Chain	ID=PRO_0000123464;Note=Unconventional myosin-VI
MYO6	Q9UM54	1046	1058	1	1294	Chain	ID=PRO_0000123464;Note=Unconventional myosin-VI
MYO6	Q9UM54	217	272	57	771	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO6	Q9UM54	272	299	57	771	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO6	Q9UM54	272	299	273	317	Region	Note=Responsible for slow ATPase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
MYO6	Q9UM54	217	272	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYO6	Q9UM54	1036	1045	1037	1068	Alternative sequence	ID=VSP_007985;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9259267;Dbxref=PMID:9259267
MYO6	Q9UM54	1046	1058	1037	1068	Alternative sequence	ID=VSP_007985;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9259267;Dbxref=PMID:9259267
MYO6	Q9UM54	1036	1045	1037	1045	Alternative sequence	ID=VSP_022332;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
MYO6	Q9UM54	217	272	246	246	Natural variant	ID=VAR_029988;Note=In DFNHCM. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060111;Dbxref=dbSNP:rs121912560,PMID:15060111
MYO6	Q9UM54	1036	1045	1026	1036	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N11
MYO6	Q9UM54	1036	1045	1038	1040	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N11
MYO6	Q9UM54	1046	1058	1055	1066	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N11
NAB2	Q15742	425	489	1	525	Chain	ID=PRO_0000077042;Note=NGFI-A-binding protein 2
NAB2	Q15742	425	489	479	479	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61127
NAB2	Q15742	425	489	323	525	Alternative sequence	ID=VSP_003386;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8668170;Dbxref=PMID:8668170
NAB2	Q15742	425	489	426	489	Alternative sequence	ID=VSP_003387;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1	2078	Chain	ID=PRO_0000425571;Note=Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1841	1845	Motif	Note=PXLXP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	41	1880	Compositional bias	Note=Pro-rich
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1181	1181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1397	1397	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	1474	1474	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70670
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	602	644	Alternative sequence	ID=VSP_053722;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	665	1774	Alternative sequence	ID=VSP_053723;Note=In isoform skNAC-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	336	336	Natural variant	ID=VAR_070547;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958127,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	405	405	Natural variant	ID=VAR_070548;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926743,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	519	519	Natural variant	ID=VAR_070549;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs185561121,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1795	1795	Natural variant	ID=VAR_070550;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2926747,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	1841	1841	Natural variant	ID=VAR_070551;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2958149,PMID:14702039
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NACA	E9PAV3	23	1886	417	417	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CROT	Q9UKG9	354	390	1	612	Chain	ID=PRO_0000210169;Note=Peroxisomal carnitine O-octanoyltransferase
CROT	Q9UKG9	533	572	1	612	Chain	ID=PRO_0000210169;Note=Peroxisomal carnitine O-octanoyltransferase
CROT	Q9UKG9	533	572	534	537	Compositional bias	Note=Poly-Gly
CROT	Q9UKG9	354	390	88	612	Alternative sequence	ID=VSP_045214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CROT	Q9UKG9	533	572	88	612	Alternative sequence	ID=VSP_045214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODAM	A1E959	176	192	16	279	Chain	ID=PRO_5000183879;Note=Odontogenic ameloblast-associated protein
ODAM	A1E959	216	270	16	279	Chain	ID=PRO_5000183879;Note=Odontogenic ameloblast-associated protein
ODAM	A1E959	176	192	62	206	Compositional bias	Note=Gln-rich
ODAM	A1E959	216	270	244	244	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	249	249	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	250	250	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	251	251	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	255	255	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	256	256	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	261	261	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	263	263	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ODAM	A1E959	216	270	222	222	Natural variant	ID=VAR_039812;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3196714,PMID:14702039
ODAM	A1E959	216	270	269	269	Natural variant	ID=VAR_039813;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NARF	Q9UHQ1	36	84	1	456	Chain	ID=PRO_0000288479;Note=Nuclear prelamin A recognition factor
NARF	Q9UHQ1	128	173	1	456	Chain	ID=PRO_0000288479;Note=Nuclear prelamin A recognition factor
NARF	Q9UHQ1	278	323	1	456	Chain	ID=PRO_0000288479;Note=Nuclear prelamin A recognition factor
NARF	Q9UHQ1	36	84	1	59	Alternative sequence	ID=VSP_046371;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NARF	Q9UHQ1	36	84	38	85	Alternative sequence	ID=VSP_025691;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NARF	Q9UHQ1	128	173	154	154	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NBEA	Q8NFP9	694	715	1	2946	Chain	ID=PRO_0000051089;Note=Neurobeachin
NBEA	Q8NFP9	748	778	1	2946	Chain	ID=PRO_0000051089;Note=Neurobeachin
NBEA	Q8NFP9	1610	1642	1	2946	Chain	ID=PRO_0000051089;Note=Neurobeachin
NBEA	Q8NFP9	694	715	1	2443	Alternative sequence	ID=VSP_050538;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NBEA	Q8NFP9	748	778	1	2443	Alternative sequence	ID=VSP_050538;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NBEA	Q8NFP9	1610	1642	1	2443	Alternative sequence	ID=VSP_050538;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NBEA	Q8NFP9	694	715	1	2207	Alternative sequence	ID=VSP_046397;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NBEA	Q8NFP9	748	778	1	2207	Alternative sequence	ID=VSP_046397;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NBEA	Q8NFP9	1610	1642	1	2207	Alternative sequence	ID=VSP_046397;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NDRG1	Q92597	269	285	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	179	198	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	150	179	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	21	33	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	269	285	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	179	198	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	150	179	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	21	33	2	394	Chain	ID=PRO_0000159573;Note=Protein NDRG1
NDRG1	Q92597	21	33	1	81	Alternative sequence	ID=VSP_045037;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NDRG1	Q92597	21	33	1	81	Alternative sequence	ID=VSP_045037;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NDRG1	Q92597	21	33	1	66	Alternative sequence	ID=VSP_045038;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NDRG1	Q92597	21	33	1	66	Alternative sequence	ID=VSP_045038;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MUS81	Q96NY9	249	279	1	551	Chain	ID=PRO_0000198858;Note=Crossover junction endonuclease MUS81
MUS81	Q96NY9	249	279	270	372	Domain	Note=ERCC4
MUS81	Q96NY9	249	279	266	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P0P
MUS81	Q96NY9	249	279	275	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZIX
MYL1	P05976	159	185	2	194	Chain	ID=PRO_0000198681;Note=Myosin light chain 1/3%2C skeletal muscle isoform
MYL1	P05976	159	185	127	162	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL1	P05976	159	185	162	194	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYO5C	Q9NQX4	1432	1462	2	1742	Chain	ID=PRO_0000123463;Note=Unconventional myosin-Vc
MYO5C	Q9NQX4	1347	1380	2	1742	Chain	ID=PRO_0000123463;Note=Unconventional myosin-Vc
MYO5C	Q9NQX4	852	901	2	1742	Chain	ID=PRO_0000123463;Note=Unconventional myosin-Vc
MYO5C	Q9NQX4	660	688	2	1742	Chain	ID=PRO_0000123463;Note=Unconventional myosin-Vc
MYO5C	Q9NQX4	582	627	2	1742	Chain	ID=PRO_0000123463;Note=Unconventional myosin-Vc
MYO5C	Q9NQX4	660	688	67	753	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO5C	Q9NQX4	582	627	67	753	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO5C	Q9NQX4	852	901	830	854	Domain	Note=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO5C	Q9NQX4	852	901	855	884	Domain	Note=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO5C	Q9NQX4	1432	1462	1421	1697	Domain	Note=Dilute;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00503
MYO5C	Q9NQX4	1347	1380	884	1351	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5C	Q9NQX4	852	901	884	1351	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5C	Q9NQX4	1432	1462	431	1742	Alternative sequence	ID=VSP_056593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5C	Q9NQX4	1347	1380	431	1742	Alternative sequence	ID=VSP_056593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5C	Q9NQX4	852	901	431	1742	Alternative sequence	ID=VSP_056593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5C	Q9NQX4	660	688	431	1742	Alternative sequence	ID=VSP_056593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5C	Q9NQX4	582	627	431	1742	Alternative sequence	ID=VSP_056593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5C	Q9NQX4	582	627	584	589	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZG4
MYO5C	Q9NQX4	582	627	624	640	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZG4
MYO5C	Q9NQX4	660	688	663	672	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZG4
MYO5C	Q9NQX4	660	688	675	684	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZG4
MYO5C	Q9NQX4	660	688	688	691	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HMP
MYO5C	Q9NQX4	1347	1380	1371	1378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L8T
MYO5C	Q9NQX4	1432	1462	1413	1433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L8T
MYO5C	Q9NQX4	1432	1462	1438	1457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L8T
MYO5C	Q9NQX4	1432	1462	1462	1464	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L8T
MYO1B	O43795	115	150	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	187	220	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	344	373	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	451	518	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	742	765	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	794	823	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	823	852	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	115	150	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	187	220	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	344	373	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	451	518	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	742	765	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	794	823	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	823	852	1	1136	Chain	ID=PRO_0000123442;Note=Unconventional myosin-Ib
MYO1B	O43795	115	150	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	187	220	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	344	373	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	451	518	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	115	150	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	187	220	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	344	373	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	451	518	15	701	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	742	765	728	748	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	742	765	728	748	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	742	765	750	779	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	742	765	750	779	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	794	823	779	808	Domain	Note=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	794	823	779	808	Domain	Note=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	794	823	808	837	Domain	Note=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	823	852	808	837	Domain	Note=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	794	823	808	837	Domain	Note=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	823	852	808	837	Domain	Note=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	823	852	837	866	Domain	Note=IQ 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	823	852	837	866	Domain	Note=IQ 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1B	O43795	115	150	108	115	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	115	150	108	115	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1B	O43795	794	823	795	852	Alternative sequence	ID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MYO1B	O43795	823	852	795	852	Alternative sequence	ID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MYO1B	O43795	794	823	795	852	Alternative sequence	ID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MYO1B	O43795	823	852	795	852	Alternative sequence	ID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MYH7B	A7E2Y1	310	343	1	1983	Chain	ID=PRO_0000349312;Note=Myosin-7B
MYH7B	A7E2Y1	310	343	126	827	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH7B	A7E2Y1	310	343	1	1809	Alternative sequence	ID=VSP_035359;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15755502;Dbxref=PMID:15755502
MYH7B	A7E2Y1	310	343	219	1983	Alternative sequence	ID=VSP_059498;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MYO7A	Q13402	6	44	1	2215	Chain	ID=PRO_0000123466;Note=Unconventional myosin-VIIa
MYO7A	Q13402	360	400	1	2215	Chain	ID=PRO_0000123466;Note=Unconventional myosin-VIIa
MYO7A	Q13402	789	862	1	2215	Chain	ID=PRO_0000123466;Note=Unconventional myosin-VIIa
MYO7A	Q13402	1095	1125	1	2215	Chain	ID=PRO_0000123466;Note=Unconventional myosin-VIIa
MYO7A	Q13402	1914	1952	1	2215	Chain	ID=PRO_0000123466;Note=Unconventional myosin-VIIa
MYO7A	Q13402	2079	2118	1	2215	Chain	ID=PRO_0000123466;Note=Unconventional myosin-VIIa
MYO7A	Q13402	360	400	65	741	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO7A	Q13402	789	862	791	811	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO7A	Q13402	789	862	814	834	Domain	Note=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO7A	Q13402	789	862	837	857	Domain	Note=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO7A	Q13402	1095	1125	1017	1253	Domain	Note=MyTH4 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00359
MYO7A	Q13402	1914	1952	1902	2205	Domain	Note=FERM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MYO7A	Q13402	2079	2118	1902	2205	Domain	Note=FERM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MYO7A	Q13402	789	862	858	935	Region	Note=SAH;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25122759;Dbxref=PMID:25122759
MYO7A	Q13402	6	44	1	11	Alternative sequence	ID=VSP_053793;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10737800;Dbxref=PMID:10737800
MYO7A	Q13402	360	400	284	360	Alternative sequence	ID=VSP_003353;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8622919;Dbxref=PMID:8622919
MYO7A	Q13402	1095	1125	1095	1095	Alternative sequence	ID=VSP_003355;Note=In isoform 4. E->EVLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8884267;Dbxref=PMID:8884267
MYO7A	Q13402	1095	1125	1096	1125	Alternative sequence	ID=VSP_003358;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8622919;Dbxref=PMID:8622919
MYO7A	Q13402	1914	1952	1201	2215	Alternative sequence	ID=VSP_003357;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8884267;Dbxref=PMID:8884267
MYO7A	Q13402	2079	2118	1201	2215	Alternative sequence	ID=VSP_003357;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8884267;Dbxref=PMID:8884267
MYO7A	Q13402	2079	2118	2117	2118	Alternative sequence	ID=VSP_045848;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8884267;Dbxref=PMID:8884267
MYO7A	Q13402	6	44	16	16	Natural variant	ID=VAR_009315;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15660226;Dbxref=dbSNP:rs1052030,PMID:15660226
MYO7A	Q13402	6	44	25	25	Natural variant	ID=VAR_009316;Note=In USH1B. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15660226,ECO:0000269|PubMed:9002678;Dbxref=dbSNP:rs782252317,PMID:15660226,PMID:9002678
MYO7A	Q13402	6	44	26	26	Natural variant	ID=VAR_024039;Note=In USH1B. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10930322;Dbxref=dbSNP:rs369125667,PMID:10930322
MYO7A	Q13402	360	400	397	397	Natural variant	ID=VAR_009325;Note=In USH1B. A->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12112664,ECO:0000269|PubMed:9382091;Dbxref=PMID:12112664,PMID:9382091
MYO7A	Q13402	789	862	826	826	Natural variant	ID=VAR_009332;Note=In USH1B. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9382091;Dbxref=dbSNP:rs368341987,PMID:9382091
MYO7A	Q13402	789	862	853	853	Natural variant	ID=VAR_027308;Note=In DFNA11%3B disturb calmodulin/MYO7A binding. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15300860;Dbxref=PMID:15300860
MYO7A	Q13402	789	862	794	794	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO7A	Q13402	789	862	794	794	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO7A	Q13402	789	862	794	794	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO7A	Q13402	1914	1952	1912	1918	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	1914	1952	1924	1934	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	1914	1952	1943	1951	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	2079	2118	2074	2085	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	2079	2118	2086	2088	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	2079	2118	2093	2104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	2079	2118	2108	2111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
MYO7A	Q13402	2079	2118	2113	2121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MV9
DBT	P11182	403	427	62	482	Chain	ID=PRO_0000020489;Note=Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex%2C mitochondrial
DBT	P11182	339	403	62	482	Chain	ID=PRO_0000020489;Note=Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex%2C mitochondrial
DBT	P11182	313	339	62	482	Chain	ID=PRO_0000020489;Note=Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex%2C mitochondrial
DBT	P11182	339	403	384	384	Natural variant	ID=VAR_015100;Note=In MSUD2. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16710414,ECO:0000269|PubMed:9621512;Dbxref=dbSNP:rs12021720,PMID:16710414,PMID:9621512
DBT	P11182	313	339	321	321	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DBT	P11182	339	403	354	354	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYB5R4	Q7L1T6	137	148	1	521	Chain	ID=PRO_0000287556;Note=Cytochrome b5 reductase 4
CYB5R4	Q7L1T6	219	230	1	521	Chain	ID=PRO_0000287556;Note=Cytochrome b5 reductase 4
CYB5R4	Q7L1T6	230	271	1	521	Chain	ID=PRO_0000287556;Note=Cytochrome b5 reductase 4
CYB5R4	Q7L1T6	271	318	1	521	Chain	ID=PRO_0000287556;Note=Cytochrome b5 reductase 4
CYB5R4	Q7L1T6	318	369	1	521	Chain	ID=PRO_0000287556;Note=Cytochrome b5 reductase 4
CYB5R4	Q7L1T6	420	448	1	521	Chain	ID=PRO_0000287556;Note=Cytochrome b5 reductase 4
CYB5R4	Q7L1T6	219	230	165	256	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
CYB5R4	Q7L1T6	230	271	165	256	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
CYB5R4	Q7L1T6	271	318	273	385	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00716
CYB5R4	Q7L1T6	318	369	273	385	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00716
CYB5R4	Q7L1T6	318	369	365	380	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
CYB5R4	Q7L1T6	420	448	392	424	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
CYB5R4	Q7L1T6	137	148	140	140	Natural variant	ID=VAR_047967;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs61762820
CYB5R4	Q7L1T6	219	230	223	223	Natural variant	ID=VAR_032324;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15504981;Dbxref=dbSNP:rs141290525,PMID:15504981
CYB5R4	Q7L1T6	230	271	267	267	Natural variant	ID=VAR_047968;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs61382555
CYB5R4	Q7L1T6	271	318	282	282	Natural variant	ID=VAR_032325;Note=S->P;Dbxref=dbSNP:rs10080628
CYB5R4	Q7L1T6	271	318	316	316	Natural variant	ID=VAR_047969;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs10080628
OLFML2A	Q68BL7	30	118	28	652	Chain	ID=PRO_0000311428;Note=Olfactomedin-like protein 2A
OLFML2A	Q68BL7	118	154	28	652	Chain	ID=PRO_0000311428;Note=Olfactomedin-like protein 2A
OLFML2A	Q68BL7	154	223	28	652	Chain	ID=PRO_0000311428;Note=Olfactomedin-like protein 2A
OLFML2A	Q68BL7	306	389	28	652	Chain	ID=PRO_0000311428;Note=Olfactomedin-like protein 2A
OLFML2A	Q68BL7	154	223	157	183	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OLFML2A	Q68BL7	154	223	207	212	Compositional bias	Note=Poly-Ala
OLFML2A	Q68BL7	306	389	354	378	Compositional bias	Note=Thr-rich
OLFML2A	Q68BL7	30	118	1	214	Alternative sequence	ID=VSP_029565;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OLFML2A	Q68BL7	118	154	1	214	Alternative sequence	ID=VSP_029565;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OLFML2A	Q68BL7	154	223	1	214	Alternative sequence	ID=VSP_029565;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OLFML2A	Q68BL7	30	118	1	39	Alternative sequence	ID=VSP_029566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
OLFML2A	Q68BL7	154	223	215	223	Alternative sequence	ID=VSP_029567;Note=In isoform 3. ATGTGSKAQ->MSKRDKAGK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OLFML2A	Q68BL7	306	389	309	309	Natural variant	ID=VAR_037250;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12975309,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs7874348,PMID:12975309,PMID:15489334
OLFML2B	Q68BL8	146	182	23	750	Chain	ID=PRO_0000311426;Note=Olfactomedin-like protein 2B
OLFML2B	Q68BL8	146	182	179	213	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OLFML2B	Q68BL8	146	182	1	517	Alternative sequence	ID=VSP_029564;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NDUFB6	O95139	91	106	2	128	Chain	ID=PRO_0000118807;Note=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
NDUFB6	O95139	91	106	92	106	Alternative sequence	ID=VSP_045233;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEK8	Q86SG6	162	206	1	692	Chain	ID=PRO_0000086432;Note=Serine/threonine-protein kinase Nek8
NEK8	Q86SG6	162	206	4	258	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK8	Q86SG6	162	206	162	162	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
NPY	P01303	63	89	29	64	Peptide	ID=PRO_0000025321;Note=Neuropeptide Y
NPY	P01303	63	89	29	64	Peptide	ID=PRO_0000025321;Note=Neuropeptide Y
NPY	P01303	63	89	29	64	Peptide	ID=PRO_0000025321;Note=Neuropeptide Y
NPY	P01303	63	89	68	97	Peptide	ID=PRO_0000025322;Note=C-flanking peptide of NPY
NPY	P01303	63	89	68	97	Peptide	ID=PRO_0000025322;Note=C-flanking peptide of NPY
NPY	P01303	63	89	68	97	Peptide	ID=PRO_0000025322;Note=C-flanking peptide of NPY
NPY	P01303	63	89	64	64	Modified residue	Note=Tyrosine amide;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6589611;Dbxref=PMID:6589611
NPY	P01303	63	89	64	64	Modified residue	Note=Tyrosine amide;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6589611;Dbxref=PMID:6589611
NPY	P01303	63	89	64	64	Modified residue	Note=Tyrosine amide;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6589611;Dbxref=PMID:6589611
NPY	P01303	63	89	83	83	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NPY	P01303	63	89	83	83	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NPY	P01303	63	89	83	83	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NPY	P01303	63	89	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QFA
NPY	P01303	63	89	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QFA
NPY	P01303	63	89	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QFA
N4BP2L2	Q92802	0	419	1	583	Chain	ID=PRO_0000299026;Note=NEDD4-binding protein 2-like 2
N4BP2L2	Q92802	0	419	162	197	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
N4BP2L2	Q92802	0	419	8	32	Alternative sequence	ID=VSP_041337;Note=In isoform 3. GKFLGPREEVTSEPRCKKLKSTTES->EFCLVRIVMALCSALMTIFTIKMGT;Ontology_term=ECO:0000305;evidence=ECO:0000305
N4BP2L2	Q92802	0	419	33	461	Alternative sequence	ID=VSP_041338;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
N4BP2L2	Q92802	0	419	272	272	Natural variant	ID=VAR_034765;Note=Y->H;Dbxref=dbSNP:rs34062461
NAA50	Q9GZZ1	48	88	1	169	Chain	ID=PRO_0000284902;Note=N-alpha-acetyltransferase 50
NAA50	Q9GZZ1	48	88	6	155	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
NAA50	Q9GZZ1	48	88	77	90	Region	Note=Acetyl-CoA binding;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2PSW,ECO:0000244|PDB:3TFY,ECO:0000244|PDB:4X5K,ECO:0000269|PubMed:21900231,ECO:0000269|PubMed:27484799,ECO:0000269|Ref.18;Dbxref=PMID:21900231,PMID:27484799
NAA50	Q9GZZ1	48	88	73	73	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21900231;Dbxref=PMID:21900231
NAA50	Q9GZZ1	48	88	75	75	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3TFY,ECO:0000244|PDB:4X5K,ECO:0000269|PubMed:21900231,ECO:0000269|PubMed:27484799;Dbxref=PMID:21900231,PMID:27484799
NAA50	Q9GZZ1	48	88	35	122	Alternative sequence	ID=VSP_024747;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NAA50	Q9GZZ1	48	88	73	73	Mutagenesis	Note=Abolishes N-alpha-acetyltransferase activity. Y->A%2CF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21900231;Dbxref=PMID:21900231
NAA50	Q9GZZ1	48	88	84	84	Mutagenesis	Note=Strongly decreased N-alpha-acetyltransferase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19744929;Dbxref=PMID:19744929
NAA50	Q9GZZ1	48	88	46	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OB0
NAA50	Q9GZZ1	48	88	54	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OB0
NAA50	Q9GZZ1	48	88	69	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OB0
NAA50	Q9GZZ1	48	88	81	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OB0
NAA50	Q9GZZ1	48	88	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X5K
NAA50	Q9GZZ1	48	88	88	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OB0
NAA15	Q9BXJ9	685	718	1	866	Chain	ID=PRO_0000106294;Note=N-alpha-acetyltransferase 15%2C NatA auxiliary subunit
NAA15	Q9BXJ9	718	767	1	866	Chain	ID=PRO_0000106294;Note=N-alpha-acetyltransferase 15%2C NatA auxiliary subunit
NAA15	Q9BXJ9	685	718	672	705	Repeat	Note=TPR 8
NAA15	Q9BXJ9	685	718	500	866	Region	Note=Interaction with HYPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20154145;Dbxref=PMID:20154145
NAA15	Q9BXJ9	718	767	500	866	Region	Note=Interaction with HYPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20154145;Dbxref=PMID:20154145
NAA15	Q9BXJ9	718	767	735	735	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NAA15	Q9BXJ9	718	767	756	756	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NAA15	Q9BXJ9	685	718	526	866	Alternative sequence	ID=VSP_012561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAA15	Q9BXJ9	718	767	526	866	Alternative sequence	ID=VSP_012561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAA15	Q9BXJ9	685	718	52	866	Natural variant	ID=VAR_080534;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	718	767	52	866	Natural variant	ID=VAR_080534;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	685	718	290	866	Natural variant	ID=VAR_080536;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	718	767	290	866	Natural variant	ID=VAR_080536;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	685	718	565	866	Natural variant	ID=VAR_080539;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	718	767	565	866	Natural variant	ID=VAR_080539;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	685	718	696	866	Natural variant	ID=VAR_080540;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	718	767	696	866	Natural variant	ID=VAR_080540;Note=In MRD50. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
NAA15	Q9BXJ9	685	718	688	701	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NAA15	Q9BXJ9	685	718	706	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NAA15	Q9BXJ9	718	767	706	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NAA15	Q9BXJ9	718	767	728	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NAA15	Q9BXJ9	718	767	747	757	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NAA15	Q9BXJ9	718	767	758	760	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C95
NAA15	Q9BXJ9	718	767	762	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NLRP5	P59047	872	928	1	1200	Chain	ID=PRO_0000080890;Note=NACHT%2C LRR and PYD domains-containing protein 5
NLRP5	P59047	872	928	865	892	Repeat	Note=LRR 6
NLRP5	P59047	872	928	893	916	Repeat	Note=LRR 7
NLRP5	P59047	872	928	912	912	Natural variant	ID=VAR_060098;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11925379;Dbxref=dbSNP:rs16986899,PMID:11925379
OFD1	O75665	218	276	1	1012	Chain	ID=PRO_0000058029;Note=Oral-facial-digital syndrome 1 protein
OFD1	O75665	312	351	1	1012	Chain	ID=PRO_0000058029;Note=Oral-facial-digital syndrome 1 protein
OFD1	O75665	829	866	1	1012	Chain	ID=PRO_0000058029;Note=Oral-facial-digital syndrome 1 protein
OFD1	O75665	829	866	615	1012	Region	Note=Mediates the interaction with SDCCAG8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20835237;Dbxref=PMID:20835237
OFD1	O75665	218	276	189	557	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OFD1	O75665	312	351	189	557	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OFD1	O75665	312	351	313	352	Alternative sequence	ID=VSP_023334;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OFD1	O75665	829	866	368	1012	Alternative sequence	ID=VSP_004178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9722947;Dbxref=PMID:9722947
CYB5R1	Q9UHQ9	158	186	1	305	Chain	ID=PRO_0000287545;Note=NADH-cytochrome b5 reductase 1
CYB5R1	Q9UHQ9	158	186	136	166	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
CYB5R1	Q9UHQ9	158	186	175	210	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
MYH15	Q9Y2K3	1897	1942	1	1946	Chain	ID=PRO_0000274233;Note=Myosin-15
MYH15	Q9Y2K3	481	538	1	1946	Chain	ID=PRO_0000274233;Note=Myosin-15
MYH15	Q9Y2K3	278	310	1	1946	Chain	ID=PRO_0000274233;Note=Myosin-15
MYH15	Q9Y2K3	481	538	103	790	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH15	Q9Y2K3	278	310	103	790	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH15	Q9Y2K3	1897	1942	853	1946	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH15	Q9Y2K3	481	538	504	504	Natural variant	ID=VAR_030236;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10231032;Dbxref=dbSNP:rs9868484,PMID:10231032
MYL6	P60660	10	58	2	151	Chain	ID=PRO_0000198690;Note=Myosin light polypeptide 6
MYL6	P60660	10	58	2	151	Chain	ID=PRO_0000198690;Note=Myosin light polypeptide 6
MYL6	P60660	10	58	7	42	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL6	P60660	10	58	7	42	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL6	P60660	10	58	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
MYL6	P60660	10	58	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
MYL6	P60660	10	58	10	10	Sequence conflict	Note=A->ADLIPST;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL6	P60660	10	58	10	10	Sequence conflict	Note=A->ADLIPST;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL6	P60660	10	58	45	45	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL6	P60660	10	58	45	45	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO1E	Q12965	928	959	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	827	875	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	602	634	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	425	454	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	396	425	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	369	396	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	170	214	1	1108	Chain	ID=PRO_0000123450;Note=Unconventional myosin-Ie
MYO1E	Q12965	602	634	19	692	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1E	Q12965	425	454	19	692	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1E	Q12965	396	425	19	692	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1E	Q12965	369	396	19	692	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1E	Q12965	170	214	19	692	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1E	Q12965	827	875	730	922	Domain	Note=TH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01093
MYO1E	Q12965	170	214	185	185	Natural variant	ID=VAR_065959;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21756023;Dbxref=dbSNP:rs141565214,PMID:21756023
MYLK2	Q9H1R3	432	474	2	596	Chain	ID=PRO_0000086408;Note=Myosin light chain kinase 2%2C skeletal/cardiac muscle
MYLK2	Q9H1R3	432	474	2	596	Chain	ID=PRO_0000086408;Note=Myosin light chain kinase 2%2C skeletal/cardiac muscle
MYLK2	Q9H1R3	432	474	285	540	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MYLK2	Q9H1R3	432	474	285	540	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MYLK2	Q9H1R3	432	474	445	445	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20689
MYLK2	Q9H1R3	432	474	445	445	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20689
MYO5A	Q9Y4I1	1444	1493	2	1855	Chain	ID=PRO_0000123456;Note=Unconventional myosin-Va
MYO5A	Q9Y4I1	1320	1346	2	1855	Chain	ID=PRO_0000123456;Note=Unconventional myosin-Va
MYO5A	Q9Y4I1	1141	1189	2	1855	Chain	ID=PRO_0000123456;Note=Unconventional myosin-Va
MYO5A	Q9Y4I1	1103	1141	2	1855	Chain	ID=PRO_0000123456;Note=Unconventional myosin-Va
MYO5A	Q9Y4I1	279	315	2	1855	Chain	ID=PRO_0000123456;Note=Unconventional myosin-Va
MYO5A	Q9Y4I1	279	315	69	763	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO5A	Q9Y4I1	1141	1189	914	1237	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5A	Q9Y4I1	1103	1141	914	1237	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5A	Q9Y4I1	1444	1493	1338	1445	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5A	Q9Y4I1	1320	1346	1338	1445	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5A	Q9Y4I1	1444	1493	1452	1452	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MYO5A	Q9Y4I1	1320	1346	1321	1347	Alternative sequence	ID=VSP_003351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7835087,ECO:0000303|PubMed:8188282,ECO:0000303|Ref.1;Dbxref=PMID:7835087,PMID:8188282
MYO5A	Q9Y4I1	1141	1189	1177	1177	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO5A	Q9Y4I1	1444	1493	1465	1477	Sequence conflict	Note=NIPRKEKDFQGML->SVLCACCVSVTVR;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO5A	Q9Y4I1	1444	1493	1471	1471	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO5A	Q9Y4I1	1444	1493	1484	1484	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO5A	Q9Y4I1	1444	1493	1475	1478	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LX2
MYO5A	Q9Y4I1	1444	1493	1481	1483	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LX2
MYO5A	Q9Y4I1	1444	1493	1484	1491	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LX2
MYO5A	Q9Y4I1	1444	1493	1492	1494	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LX2
PPP1R12A	O14974	985	1002	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	934	969	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	608	666	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	552	607	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	264	289	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	985	1002	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	934	969	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	608	666	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	552	607	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	264	289	1	1030	Chain	ID=PRO_0000067025;Note=Protein phosphatase 1 regulatory subunit 12A
PPP1R12A	O14974	608	666	519	660	Compositional bias	Note=Ser/Thr-rich
PPP1R12A	O14974	552	607	519	660	Compositional bias	Note=Ser/Thr-rich
PPP1R12A	O14974	608	666	519	660	Compositional bias	Note=Ser/Thr-rich
PPP1R12A	O14974	552	607	519	660	Compositional bias	Note=Ser/Thr-rich
PPP1R12A	O14974	552	607	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18477460;Dbxref=PMID:18477460
PPP1R12A	O14974	552	607	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18477460;Dbxref=PMID:18477460
PPP1R12A	O14974	608	666	618	618	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPP1R12A	O14974	608	666	618	618	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPP1R12A	O14974	985	1002	995	995	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPP1R12A	O14974	985	1002	995	995	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPP1R12A	O14974	552	607	552	607	Alternative sequence	ID=VSP_009251;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PPP1R12A	O14974	552	607	552	607	Alternative sequence	ID=VSP_009251;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PPP1R12A	O14974	608	666	608	666	Alternative sequence	ID=VSP_009252;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP1R12A	O14974	608	666	608	666	Alternative sequence	ID=VSP_009252;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP1R12A	O14974	934	969	935	969	Alternative sequence	ID=VSP_009253;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PPP1R12A	O14974	934	969	935	969	Alternative sequence	ID=VSP_009253;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PPP1R12A	O14974	608	666	653	653	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R12A	O14974	608	666	653	653	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R12A	O14974	934	969	959	959	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R12A	O14974	934	969	959	959	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R12A	O14974	608	666	659	668	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KJY
PPP1R12A	O14974	608	666	659	668	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KJY
PPP1R12A	O14974	934	969	932	965	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HUZ
PPP1R12A	O14974	934	969	932	965	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HUZ
NAA25	Q14CX7	883	932	1	972	Chain	ID=PRO_0000294337;Note=N-alpha-acetyltransferase 25%2C NatB auxiliary subunit
NAA25	Q14CX7	846	883	1	972	Chain	ID=PRO_0000294337;Note=N-alpha-acetyltransferase 25%2C NatB auxiliary subunit
NAA25	Q14CX7	452	482	1	972	Chain	ID=PRO_0000294337;Note=N-alpha-acetyltransferase 25%2C NatB auxiliary subunit
NAA25	Q14CX7	259	288	1	972	Chain	ID=PRO_0000294337;Note=N-alpha-acetyltransferase 25%2C NatB auxiliary subunit
NAA25	Q14CX7	134	159	1	972	Chain	ID=PRO_0000294337;Note=N-alpha-acetyltransferase 25%2C NatB auxiliary subunit
NAA25	Q14CX7	134	159	114	146	Repeat	Note=TPR 4
NAA25	Q14CX7	846	883	871	877	Compositional bias	Note=Poly-Lys
NAA25	Q14CX7	846	883	847	859	Alternative sequence	ID=VSP_026629;Note=In isoform 2. TISVILWVSSYCE->VSFCSLPKRHCCS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NAA25	Q14CX7	883	932	860	972	Alternative sequence	ID=VSP_026630;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NAA25	Q14CX7	846	883	860	972	Alternative sequence	ID=VSP_026630;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NAA25	Q14CX7	846	883	876	876	Natural variant	ID=VAR_033156;Note=K->R;Dbxref=dbSNP:rs12231744
NAA25	Q14CX7	883	932	915	915	Natural variant	ID=VAR_054100;Note=L->I;Dbxref=dbSNP:rs12298022
NAA25	Q14CX7	452	482	466	466	Sequence conflict	Note=Y->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAB1	Q13506	335	365	1	486	Chain	ID=PRO_0000077038;Note=NGFI-A-binding protein 1
NAB1	Q13506	335	365	1	486	Chain	ID=PRO_0000077038;Note=NGFI-A-binding protein 1
NAB1	Q13506	335	365	307	338	Region	Note=Necessary for nuclear localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
NAB1	Q13506	335	365	307	338	Region	Note=Necessary for nuclear localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
NAB1	Q13506	335	365	355	355	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
NAB1	Q13506	335	365	355	355	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
NAB1	Q13506	335	365	336	364	Alternative sequence	ID=VSP_003384;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NAB1	Q13506	335	365	336	364	Alternative sequence	ID=VSP_003384;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
AMDHD2	Q9Y303	138	209	1	409	Chain	ID=PRO_0000315776;Note=N-acetylglucosamine-6-phosphate deacetylase
AMDHD2	Q9Y303	323	346	1	409	Chain	ID=PRO_0000315776;Note=N-acetylglucosamine-6-phosphate deacetylase
AMDHD2	Q9Y303	346	380	1	409	Chain	ID=PRO_0000315776;Note=N-acetylglucosamine-6-phosphate deacetylase
AMDHD2	Q9Y303	138	209	154	155	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0AF18
AMDHD2	Q9Y303	323	346	328	330	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0AF18
AMDHD2	Q9Y303	138	209	143	143	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0AF18
AMDHD2	Q9Y303	323	346	323	323	Alternative sequence	ID=VSP_030698;Note=In isoform 2 and isoform 3. A->AGERPDPLGPRSQPACQVAHDPPRACPLCSQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
AMDHD2	Q9Y303	138	209	154	154	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMDHD2	Q9Y303	138	209	197	197	Sequence conflict	Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAALADL1	Q9UQQ1	296	330	1	740	Chain	ID=PRO_0000174123;Note=N-acetylated-alpha-linked acidic dipeptidase-like protein
NAALADL1	Q9UQQ1	160	201	1	740	Chain	ID=PRO_0000174123;Note=N-acetylated-alpha-linked acidic dipeptidase-like protein
NAALADL1	Q9UQQ1	296	330	29	740	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAALADL1	Q9UQQ1	160	201	29	740	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAALADL1	Q9UQQ1	296	330	263	579	Region	Note=NAALADase
NAALADL1	Q9UQQ1	296	330	299	299	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAALADL1	Q9UQQ1	160	201	161	201	Alternative sequence	ID=VSP_005343;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10085079;Dbxref=PMID:10085079
NAALADL1	Q9UQQ1	296	330	296	330	Alternative sequence	ID=VSP_005344;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10085079;Dbxref=PMID:10085079
NAALADL1	Q9UQQ1	160	201	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	160	201	171	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	160	201	188	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	160	201	198	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	296	330	300	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	296	330	305	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	296	330	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	296	330	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAALADL1	Q9UQQ1	296	330	325	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TWE
NAPSA	O96009	312	345	64	420	Chain	ID=PRO_0000025997;Note=Napsin-A
NAPSA	O96009	223	263	64	420	Chain	ID=PRO_0000025997;Note=Napsin-A
NAPSA	O96009	312	345	78	399	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
NAPSA	O96009	223	263	78	399	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
NAPSA	O96009	312	345	336	336	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAPSA	O96009	312	345	317	354	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
OLR1	P78380	59	141	1	273	Chain	ID=PRO_0000017443;Note=Oxidized low-density lipoprotein receptor 1
OLR1	P78380	59	141	58	273	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
OLR1	P78380	59	141	58	150	Region	Note=Neck
OLR1	P78380	59	141	64	123	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OLR1	P78380	59	141	73	73	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
OLR1	P78380	59	141	139	139	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22688517;Dbxref=PMID:22688517
OLR1	P78380	59	141	140	140	Disulfide bond	Note=Interchain
OLR1	P78380	59	141	70	70	Mutagenesis	Note=Abolishes sorting into the cell surface%3B when associated with 22-E--E-25. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15935375;Dbxref=PMID:15935375
OLR1	P78380	59	141	140	140	Mutagenesis	Note=Abolishes homodimerization. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15000751;Dbxref=PMID:15000751
NEK7	Q8TDX7	19	66	1	302	Chain	ID=PRO_0000086430;Note=Serine/threonine-protein kinase Nek7
NEK7	Q8TDX7	66	87	1	302	Chain	ID=PRO_0000086430;Note=Serine/threonine-protein kinase Nek7
NEK7	Q8TDX7	228	266	1	302	Chain	ID=PRO_0000086430;Note=Serine/threonine-protein kinase Nek7
NEK7	Q8TDX7	19	66	1	302	Chain	ID=PRO_0000086430;Note=Serine/threonine-protein kinase Nek7
NEK7	Q8TDX7	66	87	1	302	Chain	ID=PRO_0000086430;Note=Serine/threonine-protein kinase Nek7
NEK7	Q8TDX7	228	266	1	302	Chain	ID=PRO_0000086430;Note=Serine/threonine-protein kinase Nek7
NEK7	Q8TDX7	19	66	34	299	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK7	Q8TDX7	66	87	34	299	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK7	Q8TDX7	228	266	34	299	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK7	Q8TDX7	19	66	34	299	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK7	Q8TDX7	66	87	34	299	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK7	Q8TDX7	228	266	34	299	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK7	Q8TDX7	19	66	40	48	Nucleotide binding	Note=ATP
NEK7	Q8TDX7	19	66	40	48	Nucleotide binding	Note=ATP
NEK7	Q8TDX7	19	66	20	33	Region	Note=NTE motif
NEK7	Q8TDX7	19	66	20	33	Region	Note=NTE motif
NEK7	Q8TDX7	19	66	63	63	Binding site	Note=ATP
NEK7	Q8TDX7	19	66	63	63	Binding site	Note=ATP
NEK7	Q8TDX7	66	87	67	119	Alternative sequence	ID=VSP_041243;Note=In isoform 2. IFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDL->VCLLPVWERRVCALNACYFLEIIKGSESLQYMATLTNLFENLPVSHHGSFAKK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NEK7	Q8TDX7	66	87	67	119	Alternative sequence	ID=VSP_041243;Note=In isoform 2. IFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDL->VCLLPVWERRVCALNACYFLEIIKGSESLQYMATLTNLFENLPVSHHGSFAKK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NEK7	Q8TDX7	228	266	120	302	Alternative sequence	ID=VSP_041244;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NEK7	Q8TDX7	228	266	120	302	Alternative sequence	ID=VSP_041244;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NEK7	Q8TDX7	19	66	35	35	Natural variant	ID=VAR_040924;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55833332,PMID:17344846
NEK7	Q8TDX7	19	66	35	35	Natural variant	ID=VAR_040924;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55833332,PMID:17344846
NEK7	Q8TDX7	19	66	28	28	Mutagenesis	Note=Significant decrease in catalytic activity%3B when associated with A-31. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK7	Q8TDX7	19	66	28	28	Mutagenesis	Note=Significant decrease in catalytic activity%3B when associated with A-31. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK7	Q8TDX7	19	66	31	31	Mutagenesis	Note=Significant decrease in catalytic activity%3B when associated with A-28. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK7	Q8TDX7	19	66	31	31	Mutagenesis	Note=Significant decrease in catalytic activity%3B when associated with A-28. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK7	Q8TDX7	19	66	33	33	Mutagenesis	Note=Significant decrease in catalytic activity. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK7	Q8TDX7	19	66	33	33	Mutagenesis	Note=Significant decrease in catalytic activity. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK7	Q8TDX7	19	66	24	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	24	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	31	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	31	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	34	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	34	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	54	56	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	54	56	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	59	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	19	66	59	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	66	87	67	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQN
NEK7	Q8TDX7	66	87	67	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQN
NEK7	Q8TDX7	66	87	73	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	66	87	73	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	215	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	215	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	243	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	243	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	260	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	260	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	265	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEK7	Q8TDX7	228	266	265	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WQM
NEIL1	Q96FI4	145	184	2	390	Chain	ID=PRO_0000170905;Note=Endonuclease 8-like 1
NEIL1	Q96FI4	145	184	2	390	Chain	ID=PRO_0000170905;Note=Endonuclease 8-like 1
NEIL1	Q96FI4	145	184	2	390	Chain	ID=PRO_0000170905;Note=Endonuclease 8-like 1
NEIL1	Q96FI4	145	184	176	176	Binding site	Note=DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
NEIL1	Q96FI4	145	184	176	176	Binding site	Note=DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
NEIL1	Q96FI4	145	184	176	176	Binding site	Note=DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
NEIL1	Q96FI4	145	184	159	159	Natural variant	ID=VAR_065963;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21697813;Dbxref=dbSNP:rs769880000,PMID:21697813
NEIL1	Q96FI4	145	184	159	159	Natural variant	ID=VAR_065963;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21697813;Dbxref=dbSNP:rs769880000,PMID:21697813
NEIL1	Q96FI4	145	184	159	159	Natural variant	ID=VAR_065963;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21697813;Dbxref=dbSNP:rs769880000,PMID:21697813
NEIL1	Q96FI4	145	184	181	181	Natural variant	ID=VAR_065964;Note=Found in a patient with nephrotic syndrome also carrying mutation P-159 in MYO1E. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21697813;Dbxref=dbSNP:rs749636951,PMID:21697813
NEIL1	Q96FI4	145	184	181	181	Natural variant	ID=VAR_065964;Note=Found in a patient with nephrotic syndrome also carrying mutation P-159 in MYO1E. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21697813;Dbxref=dbSNP:rs749636951,PMID:21697813
NEIL1	Q96FI4	145	184	181	181	Natural variant	ID=VAR_065964;Note=Found in a patient with nephrotic syndrome also carrying mutation P-159 in MYO1E. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21697813;Dbxref=dbSNP:rs749636951,PMID:21697813
NEIL1	Q96FI4	145	184	182	182	Natural variant	ID=VAR_020583;Note=I->M;Dbxref=dbSNP:rs7183491
NEIL1	Q96FI4	145	184	182	182	Natural variant	ID=VAR_020583;Note=I->M;Dbxref=dbSNP:rs7183491
NEIL1	Q96FI4	145	184	182	182	Natural variant	ID=VAR_020583;Note=I->M;Dbxref=dbSNP:rs7183491
NEIL1	Q96FI4	145	184	147	147	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEIL1	Q96FI4	145	184	147	147	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEIL1	Q96FI4	145	184	147	147	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEIL1	Q96FI4	145	184	141	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	141	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	141	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	155	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	155	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	155	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	161	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	161	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	161	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	168	170	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	168	170	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	168	170	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	176	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	176	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEIL1	Q96FI4	145	184	176	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ITQ
NEK5	Q6P3R8	576	599	1	708	Chain	ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5
NEK5	Q6P3R8	524	549	1	708	Chain	ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5
NEK5	Q6P3R8	464	493	1	708	Chain	ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5
NEK5	Q6P3R8	156	184	1	708	Chain	ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5
NEK5	Q6P3R8	156	184	4	259	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK5	Q6P3R8	524	549	531	531	Natural variant	ID=VAR_040923;Note=C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
NETO2	Q8NC67	294	332	23	525	Chain	ID=PRO_0000021801;Note=Neuropilin and tolloid-like protein 2
NETO2	Q8NC67	160	175	23	525	Chain	ID=PRO_0000021801;Note=Neuropilin and tolloid-like protein 2
NETO2	Q8NC67	294	332	23	347	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NETO2	Q8NC67	160	175	23	347	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NETO2	Q8NC67	294	332	296	332	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
NETO2	Q8NC67	294	332	311	311	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NETO2	Q8NC67	294	332	297	309	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NETO2	Q8NC67	294	332	304	322	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NETO2	Q8NC67	294	332	316	331	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NETO2	Q8NC67	294	332	1	324	Alternative sequence	ID=VSP_012856;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NETO2	Q8NC67	160	175	1	324	Alternative sequence	ID=VSP_012856;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NETO2	Q8NC67	160	175	169	175	Alternative sequence	ID=VSP_053795;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NETO2	Q8NC67	294	332	325	333	Alternative sequence	ID=VSP_012857;Note=In isoform 2. PWDENHCKE->MLFTSFVEQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NTS	P30990	45	120	24	148	Chain	ID=PRO_0000019522;Note=Large neuromedin N
NEURL1B	A8MQ27	10	192	1	555	Chain	ID=PRO_0000349382;Note=E3 ubiquitin-protein ligase NEURL1B
NEURL1B	A8MQ27	192	432	1	555	Chain	ID=PRO_0000349382;Note=E3 ubiquitin-protein ligase NEURL1B
NEURL1B	A8MQ27	10	192	38	194	Domain	Note=NHR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00400
NEURL1B	A8MQ27	192	432	38	194	Domain	Note=NHR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00400
NEURL1B	A8MQ27	192	432	279	433	Domain	Note=NHR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00400
NEURL1B	A8MQ27	192	432	252	258	Compositional bias	Note=Poly-Ala
NEURL1B	A8MQ27	192	432	199	199	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NEURL1B	A8MQ27	10	192	11	192	Alternative sequence	ID=VSP_044404;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19723503;Dbxref=PMID:19723503
NEURL1B	A8MQ27	192	432	11	192	Alternative sequence	ID=VSP_044404;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19723503;Dbxref=PMID:19723503
NEURL1B	A8MQ27	10	192	191	430	Alternative sequence	ID=VSP_044405;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19723503;Dbxref=PMID:19723503
NEURL1B	A8MQ27	192	432	191	430	Alternative sequence	ID=VSP_044405;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19723503;Dbxref=PMID:19723503
MXI1	P50539	69	78	1	228	Chain	ID=PRO_0000127285;Note=Max-interacting protein 1
MXI1	P50539	69	78	67	119	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
MXI1	P50539	69	78	68	77	Alternative sequence	ID=VSP_043170;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
MYCBP2	O75592	4342	4405	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	4220	4263	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	3870	3903	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	2675	3223	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	2515	2590	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	838	874	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	4342	4405	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	4220	4263	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	3870	3903	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	2675	3223	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	2515	2590	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	838	874	1	4678	Chain	ID=PRO_0000055963;Note=E3 ubiquitin-protein ligase MYCBP2
MYCBP2	O75592	3870	3903	3719	3897	Domain	Note=DOC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00614
MYCBP2	O75592	3870	3903	3719	3897	Domain	Note=DOC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00614
MYCBP2	O75592	2515	2590	2022	2550	Region	Note=RAE1 binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22357847;Dbxref=PMID:22357847
MYCBP2	O75592	2515	2590	2022	2550	Region	Note=RAE1 binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22357847;Dbxref=PMID:22357847
MYCBP2	O75592	2675	3223	2720	2844	Compositional bias	Note=Ser-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYCBP2	O75592	2675	3223	2720	2844	Compositional bias	Note=Ser-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYCBP2	O75592	2675	3223	3194	3215	Compositional bias	Note=Lys-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYCBP2	O75592	2675	3223	3194	3215	Compositional bias	Note=Lys-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYCBP2	O75592	2675	3223	2683	2683	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
MYCBP2	O75592	2675	3223	2683	2683	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
MYCBP2	O75592	2675	3223	2769	2769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2769	2769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2787	2787	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2787	2787	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2789	2789	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MYCBP2	O75592	2675	3223	2789	2789	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MYCBP2	O75592	2675	3223	2833	2833	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2833	2833	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2839	2839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2839	2839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2869	2869	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TPH6
MYCBP2	O75592	2675	3223	2869	2869	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TPH6
MYCBP2	O75592	2675	3223	2871	2871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2871	2871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2920	2920	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
MYCBP2	O75592	2675	3223	2920	2920	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
MYCBP2	O75592	2675	3223	2985	2985	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	2985	2985	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYCBP2	O75592	2675	3223	3090	3090	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
MYCBP2	O75592	2675	3223	3090	3090	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
MYCBP2	O75592	2675	3223	3201	3201	Sequence conflict	Note=E->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYCBP2	O75592	2675	3223	3201	3201	Sequence conflict	Note=E->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC2A13	Q96QE2	440	481	1	648	Chain	ID=PRO_0000050456;Note=Proton myo-inositol cotransporter
SLC2A13	Q96QE2	440	481	415	508	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A13	Q96QE2	440	481	458	458	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH11	P35749	1098	1168	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	953	999	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	525	583	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	467	525	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	416	467	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	344	376	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	296	344	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	211	242	1	1972	Chain	ID=PRO_0000123424;Note=Myosin-11
MYH11	P35749	525	583	85	783	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH11	P35749	467	525	85	783	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH11	P35749	416	467	85	783	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH11	P35749	344	376	85	783	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH11	P35749	296	344	85	783	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH11	P35749	211	242	85	783	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH11	P35749	1098	1168	844	1934	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH11	P35749	953	999	844	1934	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH11	P35749	211	242	211	211	Alternative sequence	ID=VSP_043017;Note=In isoform 2 and isoform 3. T->TQGPSFAY;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16000639;Dbxref=PMID:15489334,PMID:16000639
MYH11	P35749	1098	1168	1104	1104	Natural variant	ID=VAR_050205;Note=A->T;Dbxref=dbSNP:rs34263860
MYOM1	P52179	835	931	1	1685	Chain	ID=PRO_0000072684;Note=Myomesin-1
MYOM1	P52179	835	931	883	883	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62234
MYOM1	P52179	835	931	887	887	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62234
MYOM1	P52179	835	931	836	931	Alternative sequence	ID=VSP_035663;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7505783;Dbxref=PMID:15489334,PMID:7505783
MYO1G	B0I1T2	842	877	1	1018	Chain	ID=PRO_0000340316;Note=Unconventional myosin-Ig
MYO1G	B0I1T2	282	357	1	1018	Chain	ID=PRO_0000340316;Note=Unconventional myosin-Ig
MYO1G	B0I1T2	188	206	1	1018	Chain	ID=PRO_0000340316;Note=Unconventional myosin-Ig
MYO1G	B0I1T2	282	357	9	707	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1G	B0I1T2	188	206	9	707	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1G	B0I1T2	842	877	824	1017	Domain	Note=TH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01093
MYO1G	B0I1T2	842	877	231	1018	Alternative sequence	ID=VSP_034209;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MYO1G	B0I1T2	282	357	231	1018	Alternative sequence	ID=VSP_034209;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MYO1G	B0I1T2	842	877	526	1018	Alternative sequence	ID=VSP_034210;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MYO1G	B0I1T2	842	877	723	1018	Alternative sequence	ID=VSP_034212;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11544309;Dbxref=PMID:11544309
MYO1G	B0I1T2	842	877	861	861	Natural variant	ID=VAR_044015;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs7792760,PMID:15489334
MYO1G	B0I1T2	842	877	876	876	Mutagenesis	Note=No effect on membrane localization. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20071333;Dbxref=PMID:20071333
MYBPC3	Q14896	689	716	1	1274	Chain	ID=PRO_0000072693;Note=Myosin-binding protein C%2C cardiac-type
MYBPC3	Q14896	689	716	645	771	Domain	Note=Ig-like C2-type 5
MYO7B	Q6PIF6	715	748	1	2116	Chain	ID=PRO_0000329046;Note=Unconventional myosin-VIIb
MYO7B	Q6PIF6	1811	1849	1	2116	Chain	ID=PRO_0000329046;Note=Unconventional myosin-VIIb
MYO7B	Q6PIF6	715	748	1	2116	Chain	ID=PRO_0000329046;Note=Unconventional myosin-VIIb
MYO7B	Q6PIF6	1811	1849	1	2116	Chain	ID=PRO_0000329046;Note=Unconventional myosin-VIIb
MYO7B	Q6PIF6	715	748	65	760	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO7B	Q6PIF6	715	748	65	760	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO7B	Q6PIF6	715	748	745	765	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO7B	Q6PIF6	715	748	745	765	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO7B	Q6PIF6	1811	1849	1790	1896	Domain	Note=MyTH4 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00359
MYO7B	Q6PIF6	1811	1849	1790	1896	Domain	Note=MyTH4 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00359
MYO7B	Q6PIF6	1811	1849	1799	2102	Domain	Note=FERM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MYO7B	Q6PIF6	1811	1849	1799	2102	Domain	Note=FERM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MYO7B	Q6PIF6	1811	1849	1501	2116	Region	Note=Mediates interaction with CDHR2%2C CDHR5 and USH1C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24725409,ECO:0000269|PubMed:26812017;Dbxref=PMID:24725409,PMID:26812017
MYO7B	Q6PIF6	1811	1849	1501	2116	Region	Note=Mediates interaction with CDHR2%2C CDHR5 and USH1C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24725409,ECO:0000269|PubMed:26812017;Dbxref=PMID:24725409,PMID:26812017
MYO7B	Q6PIF6	1811	1849	1809	1815	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1809	1815	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1821	1832	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1821	1832	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1840	1846	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1840	1846	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1849	1852	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYO7B	Q6PIF6	1811	1849	1849	1852	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XBF
MYRF	Q9Y2G1	45	132	1	1151	Chain	ID=PRO_0000318919;Note=Myelin regulatory factor
MYRF	Q9Y2G1	802	828	1	1151	Chain	ID=PRO_0000318919;Note=Myelin regulatory factor
MYRF	Q9Y2G1	921	1005	1	1151	Chain	ID=PRO_0000318919;Note=Myelin regulatory factor
MYRF	Q9Y2G1	1100	1125	1	1151	Chain	ID=PRO_0000318919;Note=Myelin regulatory factor
MYRF	Q9Y2G1	45	132	1	586	Chain	ID=PRO_0000424310;Note=Myelin regulatory factor%2C N-terminal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23966832;Dbxref=PMID:23966832
MYRF	Q9Y2G1	802	828	587	1151	Chain	ID=PRO_0000424311;Note=Myelin regulatory factor%2C C-terminal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23966832;Dbxref=PMID:23966832
MYRF	Q9Y2G1	921	1005	587	1151	Chain	ID=PRO_0000424311;Note=Myelin regulatory factor%2C C-terminal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23966832;Dbxref=PMID:23966832
MYRF	Q9Y2G1	1100	1125	587	1151	Chain	ID=PRO_0000424311;Note=Myelin regulatory factor%2C C-terminal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23966832;Dbxref=PMID:23966832
MYRF	Q9Y2G1	45	132	1	768	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYRF	Q9Y2G1	802	828	790	1151	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYRF	Q9Y2G1	921	1005	790	1151	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYRF	Q9Y2G1	1100	1125	790	1151	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYRF	Q9Y2G1	45	132	77	330	Compositional bias	Note=Pro-rich
MYRF	Q9Y2G1	45	132	123	123	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MYRF	Q9Y2G1	802	828	803	829	Alternative sequence	ID=VSP_031301;Note=In isoform 2. SFAVSTSCLLALLRPQPPGGSEALCPW->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10828591;Dbxref=PMID:10828591
MZB1	Q8WU39	101	137	23	189	Chain	ID=PRO_0000318740;Note=Marginal zone B- and B1-cell-specific protein
MZB1	Q8WU39	101	137	50	178	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MZB1	Q8WU39	101	137	53	171	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MZB1	Q8WU39	101	137	95	143	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MZB1	Q8WU39	101	137	60	189	Alternative sequence	ID=VSP_031281;Note=In isoform 2. MWQNLAKAETKLHTSNSGGRRELSELVYTDVLDRSCSRNWQDYGVREVDQVKRLTGPGLSEGPEPSISVMVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREEL->SLLVPDVAKSGKGRDQTSYLKLWGAAGAERVGLHGCPGPELLPELAGLRSSRSGPSETSHRPRT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11350957;Dbxref=PMID:11350957
MZB1	Q8WU39	101	137	63	189	Alternative sequence	ID=VSP_039074;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MZB1	Q8WU39	101	137	76	189	Alternative sequence	ID=VSP_038334;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11042152;Dbxref=PMID:11042152
MZB1	Q8WU39	101	137	93	101	Alternative sequence	ID=VSP_038332;Note=In isoform 3. RSCSRNWQD->MPAELWLTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OCIAD1	Q9NX40	19	46	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	46	64	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	182	233	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	19	46	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	46	64	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	182	233	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	19	46	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	46	64	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	182	233	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	19	46	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	46	64	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	182	233	1	245	Chain	ID=PRO_0000299382;Note=OCIA domain-containing protein 1
OCIAD1	Q9NX40	19	46	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	46	64	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	19	46	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	46	64	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	19	46	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	46	64	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	19	46	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	46	64	1	112	Domain	Note=OCIA
OCIAD1	Q9NX40	182	233	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:24275569
OCIAD1	Q9NX40	182	233	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:24275569
OCIAD1	Q9NX40	182	233	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:24275569
OCIAD1	Q9NX40	182	233	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:24275569
OCIAD1	Q9NX40	182	233	183	233	Alternative sequence	ID=VSP_046212;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
OCIAD1	Q9NX40	182	233	183	233	Alternative sequence	ID=VSP_046212;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
OCIAD1	Q9NX40	182	233	183	233	Alternative sequence	ID=VSP_046212;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
OCIAD1	Q9NX40	182	233	183	233	Alternative sequence	ID=VSP_046212;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
OCIAD1	Q9NX40	182	233	184	187	Alternative sequence	ID=VSP_027621;Note=In isoform 2. PDPN->RNFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	184	187	Alternative sequence	ID=VSP_027621;Note=In isoform 2. PDPN->RNFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	184	187	Alternative sequence	ID=VSP_027621;Note=In isoform 2. PDPN->RNFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	184	187	Alternative sequence	ID=VSP_027621;Note=In isoform 2. PDPN->RNFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	188	245	Alternative sequence	ID=VSP_027622;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	188	245	Alternative sequence	ID=VSP_027622;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	188	245	Alternative sequence	ID=VSP_027622;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD1	Q9NX40	182	233	188	245	Alternative sequence	ID=VSP_027622;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162530;Dbxref=PMID:11162530
OCIAD2	Q56VL3	72	88	1	154	Chain	ID=PRO_0000299392;Note=OCIA domain-containing protein 2
OCIAD2	Q56VL3	54	72	1	154	Chain	ID=PRO_0000299392;Note=OCIA domain-containing protein 2
OCIAD2	Q56VL3	72	88	1	120	Domain	Note=OCIA
OCIAD2	Q56VL3	54	72	1	120	Domain	Note=OCIA
NAA16	Q6N069	134	179	1	864	Chain	ID=PRO_0000106297;Note=N-alpha-acetyltransferase 16%2C NatA auxiliary subunit
NAA16	Q6N069	270	302	1	864	Chain	ID=PRO_0000106297;Note=N-alpha-acetyltransferase 16%2C NatA auxiliary subunit
NAA16	Q6N069	718	766	1	864	Chain	ID=PRO_0000106297;Note=N-alpha-acetyltransferase 16%2C NatA auxiliary subunit
NAA16	Q6N069	134	179	148	184	Repeat	Note=TPR 3
NAA16	Q6N069	718	766	312	864	Alternative sequence	ID=VSP_012563;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NAA16	Q6N069	718	766	430	864	Alternative sequence	ID=VSP_012565;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NAA16	Q6N069	718	766	517	864	Alternative sequence	ID=VSP_012567;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAA16	Q6N069	718	766	531	864	Alternative sequence	ID=VSP_012569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC4A1AP	Q9BWU0	705	734	1	796	Chain	ID=PRO_0000076268;Note=Kanadaptin
SLC4A1AP	Q9BWU0	705	734	644	715	Compositional bias	Note=Glu-rich
SLC4A1AP	Q9BWU0	705	734	709	709	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLC4A1AP	Q9BWU0	705	734	712	712	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SLC8A2	Q9UPR5	703	796	21	921	Chain	ID=PRO_0000019382;Note=Sodium/calcium exchanger 2
SLC8A2	Q9UPR5	703	796	247	720	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	721	740	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	741	747	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	748	770	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	771	772	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	773	791	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	792	822	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8A2	Q9UPR5	703	796	790	826	Repeat	Note=Alpha-2
NAGS	Q8N159	423	483	19	534	Chain	ID=PRO_0000041930;Note=N-acetylglutamate synthase long form;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGS	Q8N159	423	483	51	534	Chain	ID=PRO_0000041931;Note=N-acetylglutamate synthase short form;Ontology_term=ECO:0000250;evidence=ECO:0000250
NAGS	Q8N159	423	483	92	534	Chain	ID=PRO_0000041932;Note=N-acetylglutamate synthase conserved domain form;Ontology_term=ECO:0000250;evidence=ECO:0000250
NAGS	Q8N159	423	483	375	526	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
NAGS	Q8N159	423	483	474	479	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4K30,ECO:0000269|PubMed:23894642;Dbxref=PMID:23894642
NAGS	Q8N159	423	483	444	444	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4K30,ECO:0000269|PubMed:23894642;Dbxref=PMID:23894642
NAGS	Q8N159	423	483	430	430	Natural variant	ID=VAR_023508;Note=In NAGSD%3B markedly decreases activity. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754705,ECO:0000269|PubMed:15878741;Dbxref=dbSNP:rs104894605,PMID:12754705,PMID:15878741
NAGS	Q8N159	423	483	457	457	Natural variant	ID=VAR_077335;Note=In NAGSD%3B unknown pathological significance. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27037498;Dbxref=PMID:27037498
NAGS	Q8N159	423	483	441	441	Mutagenesis	Note=15%25 reduction in catalytic activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23894642;Dbxref=PMID:23894642
NAGS	Q8N159	423	483	479	479	Mutagenesis	Note=7-fold reduction in catalytic activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23894642;Dbxref=PMID:23894642
NAGS	Q8N159	423	483	424	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K30
NAGS	Q8N159	423	483	438	447	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K30
NAGS	Q8N159	423	483	451	467	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K30
NAGS	Q8N159	423	483	471	476	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K30
NAGS	Q8N159	423	483	482	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K30
NALCN	Q8IZF0	1230	1255	1	1738	Chain	ID=PRO_0000314010;Note=Sodium leak channel non-selective protein
NALCN	Q8IZF0	588	613	1	1738	Chain	ID=PRO_0000314010;Note=Sodium leak channel non-selective protein
NALCN	Q8IZF0	349	378	1	1738	Chain	ID=PRO_0000314010;Note=Sodium leak channel non-selective protein
NALCN	Q8IZF0	97	125	1	1738	Chain	ID=PRO_0000314010;Note=Sodium leak channel non-selective protein
NALCN	Q8IZF0	97	125	88	106	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	97	125	107	127	Transmembrane	Note=Helical%3B Name%3DS3 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	349	378	323	382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	588	613	579	599	Transmembrane	Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	588	613	600	880	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	1230	1255	1228	1235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	1230	1255	1236	1256	Transmembrane	Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255
NALCN	Q8IZF0	1230	1255	219	1738	Alternative sequence	ID=VSP_030189;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NALCN	Q8IZF0	588	613	219	1738	Alternative sequence	ID=VSP_030189;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NALCN	Q8IZF0	349	378	219	1738	Alternative sequence	ID=VSP_030189;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NALCN	Q8IZF0	588	613	589	668	Alternative sequence	ID=VSP_030190;Note=In isoform 2. ILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFID->PPSLIRDLCGTQDACPSCLPLQPPNHLPGSQTLARLTHQALTTPPGMRSSQLFSKISLLLGICVAWESILGSLSLSHNLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NALCN	Q8IZF0	1230	1255	669	1738	Alternative sequence	ID=VSP_030191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NALCN	Q8IZF0	588	613	590	590	Natural variant	ID=VAR_073366;Note=In CLIFAHDD. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25683120;Dbxref=dbSNP:rs786203986,PMID:25683120
NALCN	Q8IZF0	588	613	595	595	Natural variant	ID=VAR_076676;Note=Found in patients with distal arthrogryposis and central hypertonia%3B unknown pathological significance. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27214504;Dbxref=PMID:27214504
RAB34	P0DI83	49	70	2	198	Chain	ID=PRO_0000412533;Note=Ras-related protein Rab-34%2C isoform NARR
RAB34	P0DI83	49	70	2	198	Chain	ID=PRO_0000412533;Note=Ras-related protein Rab-34%2C isoform NARR
RAB34	P0DI83	49	70	2	198	Chain	ID=PRO_0000412533;Note=Ras-related protein Rab-34%2C isoform NARR
RAB34	P0DI83	49	70	43	51	Repeat	Note=5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	43	51	Repeat	Note=5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	43	51	Repeat	Note=5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	52	60	Repeat	Note=6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	52	60	Repeat	Note=6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	52	60	Repeat	Note=6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	61	69	Repeat	Note=7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	61	69	Repeat	Note=7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	61	69	Repeat	Note=7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	70	78	Repeat	Note=8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	70	78	Repeat	Note=8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	70	78	Repeat	Note=8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	7	125	Region	Note=13 x 9 AA approximate tandem-repeats of P-R-V-I-V-G-(S/T)-P-R
RAB34	P0DI83	49	70	7	125	Region	Note=13 x 9 AA approximate tandem-repeats of P-R-V-I-V-G-(S/T)-P-R
RAB34	P0DI83	49	70	7	125	Region	Note=13 x 9 AA approximate tandem-repeats of P-R-V-I-V-G-(S/T)-P-R
RAB34	P0DI83	49	70	69	69	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	69	69	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
RAB34	P0DI83	49	70	69	69	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21586586;Dbxref=PMID:21586586
NBR1	Q14596	34	55	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	69	134	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	232	287	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	288	357	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	508	558	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	583	620	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	620	675	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	34	55	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	69	134	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	232	287	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	288	357	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	508	558	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	583	620	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	620	675	1	966	Chain	ID=PRO_0000096746;Note=Next to BRCA1 gene 1 protein
NBR1	Q14596	34	55	4	85	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
NBR1	Q14596	69	134	4	85	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
NBR1	Q14596	34	55	4	85	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
NBR1	Q14596	69	134	4	85	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
NBR1	Q14596	232	287	211	257	Zinc finger	Note=ZZ-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00228
NBR1	Q14596	232	287	211	257	Zinc finger	Note=ZZ-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00228
NBR1	Q14596	508	558	542	636	Region	Note=ATG8 family protein-binding
NBR1	Q14596	583	620	542	636	Region	Note=ATG8 family protein-binding
NBR1	Q14596	620	675	542	636	Region	Note=ATG8 family protein-binding
NBR1	Q14596	508	558	542	636	Region	Note=ATG8 family protein-binding
NBR1	Q14596	583	620	542	636	Region	Note=ATG8 family protein-binding
NBR1	Q14596	620	675	542	636	Region	Note=ATG8 family protein-binding
NBR1	Q14596	69	134	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NBR1	Q14596	69	134	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NBR1	Q14596	583	620	590	590	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q501R9
NBR1	Q14596	583	620	590	590	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q501R9
NBR1	Q14596	583	620	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q501R9
NBR1	Q14596	583	620	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q501R9
NBR1	Q14596	620	675	625	625	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NBR1	Q14596	620	675	625	625	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NBR1	Q14596	34	55	50	50	Mutagenesis	Note=Loss of interaction with SQSTM1. D->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12813044,ECO:0000269|PubMed:19250911;Dbxref=PMID:12813044,PMID:19250911
NBR1	Q14596	34	55	50	50	Mutagenesis	Note=Loss of interaction with SQSTM1. D->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12813044,ECO:0000269|PubMed:19250911;Dbxref=PMID:12813044,PMID:19250911
NBR1	Q14596	34	55	28	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	34	55	28	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	34	55	42	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	34	55	42	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	34	55	55	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	34	55	55	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	69	134	61	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	69	134	61	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	69	134	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	69	134	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	69	134	77	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NBR1	Q14596	69	134	77	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BKF
NCAN	O14594	24	158	23	1321	Chain	ID=PRO_0000017516;Note=Neurocan core protein
NCAN	O14594	259	357	23	1321	Chain	ID=PRO_0000017516;Note=Neurocan core protein
NCAN	O14594	553	1006	23	1321	Chain	ID=PRO_0000017516;Note=Neurocan core protein
NCAN	O14594	1045	1083	23	1321	Chain	ID=PRO_0000017516;Note=Neurocan core protein
NCAN	O14594	1212	1273	23	1321	Chain	ID=PRO_0000017516;Note=Neurocan core protein
NCAN	O14594	24	158	38	153	Domain	Note=Ig-like V-type
NCAN	O14594	259	357	259	357	Domain	Note=Link 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00323
NCAN	O14594	1045	1083	1046	1082	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NCAN	O14594	1212	1273	1084	1213	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
NCAN	O14594	1212	1273	1213	1273	Domain	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
NCAN	O14594	553	1006	708	712	Region	Note=O-glycosylated at one site
NCAN	O14594	24	158	122	122	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NCAN	O14594	259	357	340	340	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NCAN	O14594	1212	1273	1223	1223	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NCAN	O14594	24	158	59	140	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	259	357	280	355	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	259	357	304	325	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	1045	1083	1050	1061	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	1045	1083	1055	1070	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	1045	1083	1072	1081	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	1212	1273	1215	1258	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	1212	1273	1244	1271	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NCAN	O14594	24	158	70	70	Natural variant	ID=VAR_024521;Note=A->T;Dbxref=dbSNP:rs2228601
NCAN	O14594	24	158	92	92	Natural variant	ID=VAR_020213;Note=P->S;Dbxref=dbSNP:rs2228603
NCAN	O14594	1212	1273	1254	1254	Natural variant	ID=VAR_016176;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9795216;Dbxref=dbSNP:rs1064389,PMID:9795216
NCAN	O14594	1212	1273	1234	1234	Sequence conflict	Note=Y->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NBAS	A2RRP1	2237	2280	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	1908	1981	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	1676	1712	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	1234	1272	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	921	979	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	780	807	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	318	361	1	2371	Chain	ID=PRO_0000292806;Note=Neuroblastoma-amplified sequence
NBAS	A2RRP1	318	361	316	355	Repeat	Note=WD 2
NBAS	A2RRP1	921	979	1	1035	Region	Note=Interaction with USE1L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369418;Dbxref=PMID:19369418
NBAS	A2RRP1	780	807	1	1035	Region	Note=Interaction with USE1L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369418;Dbxref=PMID:19369418
NBAS	A2RRP1	318	361	1	1035	Region	Note=Interaction with USE1L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369418;Dbxref=PMID:19369418
NBAS	A2RRP1	2237	2280	1036	2371	Region	Note=Interaction with ZW10 and RINT1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19369418,ECO:0000269|PubMed:20462495;Dbxref=PMID:19369418,PMID:20462495
NBAS	A2RRP1	1908	1981	1036	2371	Region	Note=Interaction with ZW10 and RINT1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19369418,ECO:0000269|PubMed:20462495;Dbxref=PMID:19369418,PMID:20462495
NBAS	A2RRP1	1676	1712	1036	2371	Region	Note=Interaction with ZW10 and RINT1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19369418,ECO:0000269|PubMed:20462495;Dbxref=PMID:19369418,PMID:20462495
NBAS	A2RRP1	1234	1272	1036	2371	Region	Note=Interaction with ZW10 and RINT1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19369418,ECO:0000269|PubMed:20462495;Dbxref=PMID:19369418,PMID:20462495
NBAS	A2RRP1	2237	2280	2242	2247	Compositional bias	Note=Poly-Leu
NBAS	A2RRP1	921	979	860	979	Alternative sequence	ID=VSP_026445;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NBAS	A2RRP1	318	361	348	348	Natural variant	ID=VAR_074647;Note=In ILFS2. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26073778;Dbxref=PMID:26073778
NBAS	A2RRP1	921	979	949	949	Natural variant	ID=VAR_068955;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20577004;Dbxref=dbSNP:rs74727069,PMID:20577004
NBAS	A2RRP1	1908	1981	1914	1914	Natural variant	ID=VAR_068957;Note=In SOPH. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20577004;Dbxref=dbSNP:rs369698072,PMID:20577004
NCDN	Q9UBB6	462	536	2	729	Chain	ID=PRO_0000324617;Note=Neurochondrin
NCDN	Q9UBB6	462	536	2	729	Chain	ID=PRO_0000324617;Note=Neurochondrin
NCKAP5L	Q9HCH0	1113	1216	1	1330	Chain	ID=PRO_0000288447;Note=Nck-associated protein 5-like
NCKAP5L	Q9HCH0	117	155	1	1330	Chain	ID=PRO_0000288447;Note=Nck-associated protein 5-like
NCKAP5L	Q9HCH0	64	77	1	1330	Chain	ID=PRO_0000288447;Note=Nck-associated protein 5-like
NCKAP5L	Q9HCH0	117	155	1	135	Region	Note=Mediates interaction with CDK5RAP2 and is required for homodimerization and microtubule bundle formation;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26482847,ECO:0000269|PubMed:26485573;Dbxref=PMID:26482847,PMID:26485573
NCKAP5L	Q9HCH0	64	77	1	135	Region	Note=Mediates interaction with CDK5RAP2 and is required for homodimerization and microtubule bundle formation;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26482847,ECO:0000269|PubMed:26485573;Dbxref=PMID:26482847,PMID:26485573
NCKAP5L	Q9HCH0	1113	1216	746	1142	Region	Note=Mediates interaction with beta-tubulin and is required for microtubule bundle formation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26482847;Dbxref=PMID:26482847
NCKAP5L	Q9HCH0	64	77	24	102	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NCKAP5L	Q9HCH0	117	155	112	614	Compositional bias	Note=Pro-rich
NCKAP5L	Q9HCH0	1113	1216	1042	1283	Compositional bias	Note=Pro-rich
NCKAP5L	Q9HCH0	1113	1216	1190	1190	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NCKAP5L	Q9HCH0	64	77	62	108	Alternative sequence	ID=VSP_033818;Note=In isoform 4. ANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTT->CGSVVGLGGCGSSAPGRSWGQLMALPRGFLSPGCQPCGTGVAEPEGE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NCKAP5L	Q9HCH0	1113	1216	109	1330	Alternative sequence	ID=VSP_033819;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NCKAP5L	Q9HCH0	117	155	109	1330	Alternative sequence	ID=VSP_033819;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NCKAP1	Q9Y2A7	718	790	2	1128	Chain	ID=PRO_0000216172;Note=Nck-associated protein 1
NCKAP1	Q9Y2A7	316	334	2	1128	Chain	ID=PRO_0000216172;Note=Nck-associated protein 1
NCKAP1	Q9Y2A7	201	247	2	1128	Chain	ID=PRO_0000216172;Note=Nck-associated protein 1
NCKAP1	Q9Y2A7	201	247	200	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	209	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	214	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	221	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	227	230	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	236	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	201	247	239	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N78
NCKAP1	Q9Y2A7	316	334	315	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	316	334	320	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	704	723	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	728	731	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	736	752	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	753	755	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	761	771	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	774	776	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
NCKAP1	Q9Y2A7	718	790	784	794	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P8C
OAT	P04181	216	257	26	439	Chain	ID=PRO_0000001262;Note=Ornithine aminotransferase%2C hepatic form
OAT	P04181	216	257	36	439	Chain	ID=PRO_0000001263;Note=Ornithine aminotransferase%2C renal form
OAT	P04181	216	257	226	226	Natural variant	ID=VAR_000572;Note=In HOGA%3B loss of activity and protein stability. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23076989,ECO:0000269|PubMed:7887415;Dbxref=dbSNP:rs121965059,PMID:23076989,PMID:7887415
OAT	P04181	216	257	241	241	Natural variant	ID=VAR_000573;Note=In HOGA. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1612597,ECO:0000269|PubMed:1737786;Dbxref=dbSNP:rs121965051,PMID:1612597,PMID:1737786
OAT	P04181	216	257	245	245	Natural variant	ID=VAR_000574;Note=In HOGA. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1737786;Dbxref=dbSNP:rs121965046,PMID:1737786
OAT	P04181	216	257	250	250	Natural variant	ID=VAR_000575;Note=In HOGA. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1612597,ECO:0000269|PubMed:1737786;Dbxref=dbSNP:rs121965052,PMID:1612597,PMID:1737786
OAT	P04181	216	257	212	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VWO
OAT	P04181	216	257	224	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VWO
OAT	P04181	216	257	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VWO
OAT	P04181	216	257	234	237	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VWO
OAT	P04181	216	257	245	255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VWO
MYO3A	Q8NEV4	101	136	1	1616	Chain	ID=PRO_0000086413;Note=Myosin-IIIa
MYO3A	Q8NEV4	266	317	1	1616	Chain	ID=PRO_0000086413;Note=Myosin-IIIa
MYO3A	Q8NEV4	905	931	1	1616	Chain	ID=PRO_0000086413;Note=Myosin-IIIa
MYO3A	Q8NEV4	1529	1576	1	1616	Chain	ID=PRO_0000086413;Note=Myosin-IIIa
MYO3A	Q8NEV4	101	136	21	287	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MYO3A	Q8NEV4	266	317	21	287	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MYO3A	Q8NEV4	905	931	338	1053	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO3A	Q8NEV4	266	317	248	1616	Alternative sequence	ID=VSP_056232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO3A	Q8NEV4	905	931	248	1616	Alternative sequence	ID=VSP_056232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO3A	Q8NEV4	1529	1576	248	1616	Alternative sequence	ID=VSP_056232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO1D	O94832	865	903	2	1006	Chain	ID=PRO_0000123447;Note=Unconventional myosin-Id
MYO1D	O94832	513	537	2	1006	Chain	ID=PRO_0000123447;Note=Unconventional myosin-Id
MYO1D	O94832	432	489	2	1006	Chain	ID=PRO_0000123447;Note=Unconventional myosin-Id
MYO1D	O94832	277	345	2	1006	Chain	ID=PRO_0000123447;Note=Unconventional myosin-Id
MYO1D	O94832	188	206	2	1006	Chain	ID=PRO_0000123447;Note=Unconventional myosin-Id
MYO1D	O94832	513	537	9	695	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1D	O94832	432	489	9	695	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1D	O94832	277	345	9	695	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1D	O94832	188	206	9	695	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1D	O94832	865	903	812	1005	Domain	Note=TH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01093
MYO1D	O94832	188	206	200	200	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MYO1D	O94832	513	537	536	536	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SYD0
MYH9	P35579	1448	1519	2	1960	Chain	ID=PRO_0000123416;Note=Myosin-9
MYH9	P35579	409	460	2	1960	Chain	ID=PRO_0000123416;Note=Myosin-9
MYH9	P35579	289	337	2	1960	Chain	ID=PRO_0000123416;Note=Myosin-9
MYH9	P35579	409	460	81	776	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH9	P35579	289	337	81	776	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYH9	P35579	409	460	2	838	Region	Note=Mediates interaction with LIMCH1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28228547;Dbxref=PMID:28228547
MYH9	P35579	289	337	2	838	Region	Note=Mediates interaction with LIMCH1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28228547;Dbxref=PMID:28228547
MYH9	P35579	1448	1519	837	1926	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH9	P35579	289	337	299	299	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MYH9	P35579	409	460	435	435	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35580
MYH9	P35579	1448	1519	1459	1459	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MYH9	P35579	1448	1519	1462	1462	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAA40	Q86UY6	52	83	2	237	Chain	ID=PRO_0000284897;Note=N-alpha-acetyltransferase 40
NAA40	Q86UY6	52	83	63	216	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
NAA40	Q86UY6	52	83	55	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U9V
NAA40	Q86UY6	52	83	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U9V
NAA40	Q86UY6	52	83	67	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U9V
NAA10	P41227	114	128	1	235	Chain	ID=PRO_0000074532;Note=N-alpha-acetyltransferase 10
NAA10	P41227	114	128	1	152	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
NAA10	P41227	114	128	114	128	Alternative sequence	ID=VSP_046205;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAA10	P41227	114	128	116	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C9M
NADSYN1	Q6IA69	49	87	1	706	Chain	ID=PRO_0000237577;Note=Glutamine-dependent NAD(+) synthetase
NADSYN1	Q6IA69	588	631	1	706	Chain	ID=PRO_0000237577;Note=Glutamine-dependent NAD(+) synthetase
NADSYN1	Q6IA69	49	87	5	275	Domain	Note=CN hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00054
NADSYN1	Q6IA69	588	631	325	706	Region	Note=Ligase;Ontology_term=ECO:0000250;evidence=ECO:0000250
NADSYN1	Q6IA69	49	87	7	266	Alternative sequence	ID=VSP_056586;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NADSYN1	Q6IA69	49	87	74	74	Natural variant	ID=VAR_026497;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2276360,PMID:14702039,PMID:15489334
NADSYN1	Q6IA69	588	631	591	591	Natural variant	ID=VAR_056205;Note=M->I;Dbxref=dbSNP:rs35007971
NADSYN1	Q6IA69	588	631	623	623	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
DLST	P36957	66	91	1	67	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
DLST	P36957	66	91	68	453	Chain	ID=PRO_0000020472;Note=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex%2C mitochondrial
DLST	P36957	353	409	68	453	Chain	ID=PRO_0000020472;Note=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex%2C mitochondrial
DLST	P36957	66	91	70	144	Domain	Note=Lipoyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066
DLST	P36957	66	91	81	81	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D2G2
DLST	P36957	66	91	24	109	Alternative sequence	ID=VSP_056440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DLST	P36957	353	409	384	384	Natural variant	ID=VAR_004977;Note=P->T
NADK	O95544	60	87	1	446	Chain	ID=PRO_0000120713;Note=NAD kinase
NADK	O95544	60	87	1	446	Chain	ID=PRO_0000120713;Note=NAD kinase
NADK	O95544	60	87	64	64	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
NADK	O95544	60	87	64	64	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
NADK	O95544	60	87	11	87	Alternative sequence	ID=VSP_047312;Note=In isoform 3. NKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTI->GRPRVRQAWPGCCGHTGRLPAGRGYLASHMCDPAGAELIGDGMSDPTPPSNACT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NADK	O95544	60	87	11	87	Alternative sequence	ID=VSP_047312;Note=In isoform 3. NKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTI->GRPRVRQAWPGCCGHTGRLPAGRGYLASHMCDPAGAELIGDGMSDPTPPSNACT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NADK	O95544	60	87	75	77	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	75	77	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	87	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
NADK	O95544	60	87	87	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PFN
DLAT	P10515	430	466	87	647	Chain	ID=PRO_0000020479;Note=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex%2C mitochondrial
DLAT	P10515	430	466	417	647	Region	Note=Catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
DLAT	P10515	430	466	466	466	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DLAT	P10515	430	466	451	451	Natural variant	ID=VAR_047416;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs10891314
DLAT	P10515	430	466	427	440	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CT0
DLAT	P10515	430	466	446	453	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CT0
DLAT	P10515	430	466	455	467	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CT0
NAGA	P17050	199	253	18	411	Chain	ID=PRO_0000001018;Note=Alpha-N-acetylgalactosaminidase
NAGA	P17050	199	253	18	411	Chain	ID=PRO_0000001018;Note=Alpha-N-acetylgalactosaminidase
NAGA	P17050	199	253	18	411	Chain	ID=PRO_0000001018;Note=Alpha-N-acetylgalactosaminidase
NAGA	P17050	199	253	217	217	Active site	Note=Proton donor
NAGA	P17050	199	253	217	217	Active site	Note=Proton donor
NAGA	P17050	199	253	217	217	Active site	Note=Proton donor
NAGA	P17050	199	253	213	213	Binding site	Note=Substrate
NAGA	P17050	199	253	213	213	Binding site	Note=Substrate
NAGA	P17050	199	253	213	213	Binding site	Note=Substrate
NAGA	P17050	199	253	217	217	Binding site	Note=Substrate
NAGA	P17050	199	253	217	217	Binding site	Note=Substrate
NAGA	P17050	199	253	217	217	Binding site	Note=Substrate
NAGA	P17050	199	253	201	201	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
NAGA	P17050	199	253	201	201	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
NAGA	P17050	199	253	201	201	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
NAGA	P17050	199	253	187	209	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19683538;Dbxref=PMID:19683538
NAGA	P17050	199	253	187	209	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19683538;Dbxref=PMID:19683538
NAGA	P17050	199	253	187	209	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19683538;Dbxref=PMID:19683538
NAGA	P17050	199	253	201	201	Mutagenesis	Note=Loss of glycosylation site%3B no effect on enzyme activity and stability. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19683538;Dbxref=PMID:19683538
NAGA	P17050	199	253	201	201	Mutagenesis	Note=Loss of glycosylation site%3B no effect on enzyme activity and stability. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19683538;Dbxref=PMID:19683538
NAGA	P17050	199	253	201	201	Mutagenesis	Note=Loss of glycosylation site%3B no effect on enzyme activity and stability. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19683538;Dbxref=PMID:19683538
NAGA	P17050	199	253	205	205	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAGA	P17050	199	253	205	205	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAGA	P17050	199	253	205	205	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAGA	P17050	199	253	197	199	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	197	199	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	197	199	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	202	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	202	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	202	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	210	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	210	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	210	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	222	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	222	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	222	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	236	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	236	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	236	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	240	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	240	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	240	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAGA	P17050	199	253	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DO4
NAMPT	P43490	363	410	1	491	Chain	ID=PRO_0000205863;Note=Nicotinamide phosphoribosyltransferase
NAMPT	P43490	323	363	1	491	Chain	ID=PRO_0000205863;Note=Nicotinamide phosphoribosyltransferase
NAMPT	P43490	149	202	1	491	Chain	ID=PRO_0000205863;Note=Nicotinamide phosphoribosyltransferase
NAMPT	P43490	323	363	353	354	Region	Note=Nicotinamide ribonucleotide binding
NAMPT	P43490	149	202	196	196	Binding site	Note=Diphosphate
NAMPT	P43490	363	410	384	384	Binding site	Note=Nicotinamide ribonucleotide%3B via amide nitrogen
NAMPT	P43490	363	410	392	392	Binding site	Note=Nicotinamide ribonucleotide
NAMPT	P43490	149	202	188	188	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
NAMPT	P43490	149	202	176	176	Natural variant	ID=VAR_036614;Note=In a colorectal cancer sample%3B somatic mutation. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NAMPT	P43490	149	202	149	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	149	202	156	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	149	202	186	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	149	202	189	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	149	202	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	149	202	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NSD
NAMPT	P43490	149	202	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	323	363	317	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	323	363	338	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GVJ
NAMPT	P43490	323	363	348	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	358	370	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	323	363	358	370	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	375	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	378	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	384	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	392	396	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	397	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NAMPT	P43490	363	410	409	412	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LVF
NLRP4	Q96MN2	729	784	1	994	Chain	ID=PRO_0000080889;Note=NACHT%2C LRR and PYD domains-containing protein 4
NLRP4	Q96MN2	842	898	1	994	Chain	ID=PRO_0000080889;Note=NACHT%2C LRR and PYD domains-containing protein 4
NLRP4	Q96MN2	729	784	722	745	Repeat	Note=LRR 3
NLRP4	Q96MN2	729	784	750	777	Repeat	Note=LRR 4
NLRP4	Q96MN2	842	898	863	886	Repeat	Note=LRR 6
NLRP4	Q96MN2	729	784	731	786	Alternative sequence	ID=VSP_044007;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NLRP4	Q96MN2	729	784	774	774	Natural variant	ID=VAR_024829;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854614,PMID:15489334
NLRP11	P59045	838	894	1	1033	Chain	ID=PRO_0000080898;Note=NACHT%2C LRR and PYD domains-containing protein 11
NLRP11	P59045	614	667	1	1033	Chain	ID=PRO_0000080898;Note=NACHT%2C LRR and PYD domains-containing protein 11
NLRP11	P59045	614	667	632	655	Repeat	Note=LRR 2
NLRP11	P59045	838	894	859	882	Repeat	Note=LRR 5
NLRP11	P59045	614	667	614	668	Alternative sequence	ID=VSP_007068;Note=In isoform 2. SQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLK->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAV3	Q8IVL0	224	246	1	2385	Chain	ID=PRO_0000286976;Note=Neuron navigator 3
NAV3	Q8IVL0	1250	1412	1	2385	Chain	ID=PRO_0000286976;Note=Neuron navigator 3
NAV3	Q8IVL0	1413	1426	1	2385	Chain	ID=PRO_0000286976;Note=Neuron navigator 3
NAV3	Q8IVL0	1766	1787	1	2385	Chain	ID=PRO_0000286976;Note=Neuron navigator 3
NAV3	Q8IVL0	1250	1412	1032	1560	Compositional bias	Note=Ser-rich
NAV3	Q8IVL0	1413	1426	1032	1560	Compositional bias	Note=Ser-rich
NAV3	Q8IVL0	1250	1412	1250	1426	Alternative sequence	ID=VSP_025268;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
NAV3	Q8IVL0	1413	1426	1250	1426	Alternative sequence	ID=VSP_025268;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
NAV3	Q8IVL0	1766	1787	1767	1788	Alternative sequence	ID=VSP_025269;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:12079279;Dbxref=PMID:10231032,PMID:12079279
NAT10	Q9H0A0	769	806	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	864	904	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	904	937	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	769	806	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	864	904	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	904	937	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	904	937	934	934	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NAT10	Q9H0A0	864	904	879	879	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NBN	O60934	690	728	1	754	Chain	ID=PRO_0000231043;Note=Nibrin
NBN	O60934	638	690	1	754	Chain	ID=PRO_0000231043;Note=Nibrin
NBN	O60934	615	638	1	754	Chain	ID=PRO_0000231043;Note=Nibrin
NBN	O60934	615	638	615	615	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10839545;Dbxref=PMID:10839545
NBN	O60934	638	690	673	673	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NBN	O60934	638	690	679	679	Natural variant	ID=VAR_064738;Note=Found in a renal cell carcinoma sample%3B somatic mutation. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752
NBN	O60934	615	638	615	615	Mutagenesis	Note=Abrogates ATM-dependent phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10839545;Dbxref=PMID:10839545
CHL1	O00533	1015	1068	25	1208	Chain	ID=PRO_0000247896;Note=Neural cell adhesion molecule L1-like protein
CHL1	O00533	1015	1068	25	1082	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHL1	O00533	1015	1068	918	1015	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CHL1	O00533	1015	1068	1039	1040	Site	Note=Cleavage%3B by ADAM8;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHL1	O00533	1015	1068	1026	1026	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
CHL1	O00533	1015	1068	1034	1034	Natural variant	ID=VAR_027169;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9799093,ECO:0000269|Ref.2;Dbxref=dbSNP:rs6442827,PMID:15489334,PMID:9799093
NCBP1	Q09161	127	163	1	790	Chain	ID=PRO_0000089364;Note=Nuclear cap-binding protein subunit 1
NCBP1	Q09161	227	299	1	790	Chain	ID=PRO_0000089364;Note=Nuclear cap-binding protein subunit 1
NCBP1	Q09161	127	163	28	240	Domain	Note=MIF4G
NCBP1	Q09161	227	299	28	240	Domain	Note=MIF4G
NCBP1	Q09161	127	163	159	159	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCBP1	Q09161	127	163	121	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	127	163	138	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N52
NCBP1	Q09161	127	163	142	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	127	163	155	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	127	163	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6D0Y
NCBP1	Q09161	127	163	163	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	228	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	242	244	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	247	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N54
NCBP1	Q09161	227	299	252	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	257	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	294	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	298	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N52
NCKAP5	O14513	143	193	1	1909	Chain	ID=PRO_0000096711;Note=Nck-associated protein 5
NCKAP5	O14513	143	193	71	253	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NCKAP5	O14513	143	193	119	1909	Alternative sequence	ID=VSP_021603;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NCKAP1L	P55160	314	332	1	1127	Chain	ID=PRO_0000216175;Note=Nck-associated protein 1-like
NCKAP1L	P55160	719	791	1	1127	Chain	ID=PRO_0000216175;Note=Nck-associated protein 1-like
NCKAP1L	P55160	719	791	768	769	Sequence conflict	Note=NA->KP;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCOR1	O75376	2318	2378	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	2226	2244	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	2131	2178	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	1960	2003	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	1700	1740	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	1504	1580	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	1270	1298	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	1099	1133	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	206	244	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	145	206	1	2440	Chain	ID=PRO_0000055617;Note=Nuclear receptor corepressor 1
NCOR1	O75376	206	244	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14527417,ECO:0000269|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
NCOR1	O75376	145	206	1	373	Region	Note=Interaction with ZBTB33 and HEXIM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14527417,ECO:0000269|PubMed:17452463;Dbxref=PMID:14527417,PMID:17452463
NCOR1	O75376	1700	1740	988	1816	Region	Note=Interaction with ETO
NCOR1	O75376	1504	1580	988	1816	Region	Note=Interaction with ETO
NCOR1	O75376	1270	1298	988	1816	Region	Note=Interaction with ETO
NCOR1	O75376	1099	1133	988	1816	Region	Note=Interaction with ETO
NCOR1	O75376	2318	2378	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	2226	2244	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	2131	2178	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	1960	2003	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	1700	1740	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	1504	1580	1501	2440	Region	Note=Interaction with C1D;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	2226	2244	2212	2273	Region	Note=ID2;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR1	O75376	206	244	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NCOR1	O75376	145	206	174	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NCOR1	O75376	1700	1740	1707	1712	Compositional bias	Note=Poly-Ala
NCOR1	O75376	1960	2003	1952	1963	Compositional bias	Note=Poly-Ser
NCOR1	O75376	145	206	172	172	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NCOR1	O75376	206	244	224	224	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:23186163,PMID:24275569
NCOR1	O75376	1099	1133	1111	1111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NCOR1	O75376	1270	1298	1281	1281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NCOR1	O75376	1960	2003	1977	1977	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
NCOR1	O75376	1960	2003	1981	1981	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NCOR1	O75376	2131	2178	2136	2136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NCOR1	O75376	2131	2178	2151	2151	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
NCOR1	O75376	1099	1133	1106	1106	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
NCOR1	O75376	1099	1133	1106	1106	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
NCOR1	O75376	1504	1580	1518	1518	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
NCOR1	O75376	145	206	37	145	Alternative sequence	ID=VSP_046468;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	2318	2378	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	2226	2244	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	2131	2178	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	1960	2003	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	1700	1740	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	1504	1580	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	1270	1298	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	1099	1133	1008	2440	Alternative sequence	ID=VSP_046470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NCOR1	O75376	1960	2003	1842	1961	Alternative sequence	ID=VSP_010208;Note=In isoform 2. SKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSSL->I;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
NCOR1	O75376	1504	1580	1508	1509	Sequence conflict	Note=SS->PP;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCOR1	O75376	1504	1580	1561	1561	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCOR1	O75376	1504	1580	1567	1567	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCOR2	Q9Y618	2319	2394	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	2301	2319	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	2202	2251	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	1729	1779	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	1571	1645	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	1161	1196	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	1033	1080	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	722	739	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	604	625	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	235	254	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
NCOR2	Q9Y618	604	625	610	661	Domain	Note=SANT 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
NCOR2	Q9Y618	235	254	254	312	Region	Note=Interaction with SIN3A/B;Ontology_term=ECO:0000250;evidence=ECO:0000250
NCOR2	Q9Y618	2319	2394	2339	2343	Motif	Note=CORNR box of ID2
NCOR2	Q9Y618	1161	1196	1173	1173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NCOR2	Q9Y618	1571	1645	1595	1595	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WU42
NCOR2	Q9Y618	1571	1645	1619	1619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NCOR2	Q9Y618	1729	1779	1775	1775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NCOR2	Q9Y618	1729	1779	1778	1778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
NCOR2	Q9Y618	2202	2251	2203	2203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NCOR2	Q9Y618	2202	2251	2223	2223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
NCOR2	Q9Y618	1161	1196	1168	1168	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
NCOR2	Q9Y618	1571	1645	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8813722;Dbxref=PMID:8813722
NCOR2	Q9Y618	1161	1196	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8813722;Dbxref=PMID:8813722
NCOR2	Q9Y618	1033	1080	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8813722;Dbxref=PMID:8813722
NCOR2	Q9Y618	722	739	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8813722;Dbxref=PMID:8813722
NCOR2	Q9Y618	604	625	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8813722;Dbxref=PMID:8813722
NCOR2	Q9Y618	235	254	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8813722;Dbxref=PMID:8813722
NCOR2	Q9Y618	722	739	724	740	Alternative sequence	ID=VSP_036595;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10097068,ECO:0000303|Ref.4;Dbxref=PMID:10097068
NCOR2	Q9Y618	2319	2394	2350	2395	Alternative sequence	ID=VSP_003413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8813722,ECO:0000303|Ref.4;Dbxref=PMID:8813722
NCOR2	Q9Y618	235	254	242	245	Mutagenesis	Note=Abolishes interaction with TBL1X. HRIL->AEIA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21240272;Dbxref=PMID:21240272
NCOR2	Q9Y618	604	625	612	613	Sequence conflict	Note=SS->EF;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCOR2	Q9Y618	604	625	617	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LTP
NCOR2	Q9Y618	2319	2394	2337	2347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X8Q
NME3	Q13232	59	93	1	169	Chain	ID=PRO_0000137123;Note=Nucleoside diphosphate kinase 3
NME3	Q13232	59	93	77	77	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
NME3	Q13232	59	93	60	60	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NME3	Q13232	59	93	62	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZS6
NME3	Q13232	59	93	70	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZS6
NME3	Q13232	59	93	78	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZS6
NME3	Q13232	59	93	90	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZS6
NDOR1	Q9UHB4	137	170	1	597	Chain	ID=PRO_0000319539;Note=NADPH-dependent diflavin oxidoreductase 1
NDOR1	Q9UHB4	137	170	6	150	Domain	Note=Flavodoxin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03178
NDOR1	Q9UHB4	137	170	158	161	Compositional bias	Note=Poly-Pro
NDOR1	Q9UHB4	137	170	138	171	Alternative sequence	ID=VSP_046313;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NDOR1	Q9UHB4	137	170	135	138	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2D
NDOR1	Q9UHB4	137	170	139	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2D
NME7	Q9Y5B8	330	366	1	376	Chain	ID=PRO_0000137130;Note=Nucleoside diphosphate kinase 7
NME7	Q9Y5B8	296	330	1	376	Chain	ID=PRO_0000137130;Note=Nucleoside diphosphate kinase 7
NME7	Q9Y5B8	130	146	1	376	Chain	ID=PRO_0000137130;Note=Nucleoside diphosphate kinase 7
NME7	Q9Y5B8	93	129	1	376	Chain	ID=PRO_0000137130;Note=Nucleoside diphosphate kinase 7
NME7	Q9Y5B8	93	129	99	99	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
NME7	Q9Y5B8	130	146	145	145	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS7	O75251	18	40	1	38	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS7	O75251	18	40	39	213	Chain	ID=PRO_0000020027;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 7%2C mitochondrial
NDUFS7	O75251	76	136	39	213	Chain	ID=PRO_0000020027;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 7%2C mitochondrial
NDUFS7	O75251	76	136	88	88	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000255;evidence=ECO:0000255
NDUFS7	O75251	76	136	89	89	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000255;evidence=ECO:0000255
NDUFS7	O75251	76	136	111	111	Modified residue	Note=Hydroxyarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42026
NDUFS7	O75251	18	40	23	23	Natural variant	ID=VAR_014482;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1142530,PMID:15489334
NDUFS7	O75251	76	136	122	122	Natural variant	ID=VAR_008848;Note=In MT-C1D. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10330338,ECO:0000269|PubMed:10360771;Dbxref=dbSNP:rs104894705,PMID:10330338,PMID:10360771
NDUFS7	O75251	76	136	60	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	90	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	103	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	114	116	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	128	130	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS7	O75251	76	136	131	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NTN1	O95631	339	402	25	604	Chain	ID=PRO_0000017082;Note=Netrin-1
NTN1	O95631	452	470	25	604	Chain	ID=PRO_0000017082;Note=Netrin-1
NTN1	O95631	470	495	25	604	Chain	ID=PRO_0000017082;Note=Netrin-1
NTN1	O95631	339	402	285	340	Domain	Note=Laminin EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
NTN1	O95631	339	402	341	403	Domain	Note=Laminin EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
NTN1	O95631	452	470	404	453	Domain	Note=Laminin EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
NTN1	O95631	470	495	472	601	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
NTN1	O95631	339	402	341	350	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN1	O95631	339	402	343	368	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN1	O95631	339	402	371	380	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN1	O95631	339	402	383	401	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN1	O95631	470	495	472	544	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN1	O95631	470	495	491	601	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN1	O95631	339	402	351	351	Natural variant	ID=VAR_014279;Note=In a neuroblastoma sample. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9950216;Dbxref=dbSNP:rs531668666,PMID:9950216
NTN1	O95631	470	495	489	489	Natural variant	ID=VAR_014280;Note=In a neuroblastoma sample. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9950216;Dbxref=PMID:9950216
NTN1	O95631	339	402	344	346	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	354	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	366	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	372	374	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	375	380	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	387	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	339	402	401	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FKQ
NTN1	O95631	452	470	451	453	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URT
ART3	Q13508	260	271	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	282	292	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	302	312	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	292	302	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	302	312	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	282	292	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	323	334	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	334	345	27	362	Chain	ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3
ART3	Q13508	282	292	283	292	Repeat	Note=1
ART3	Q13508	292	302	283	292	Repeat	Note=1
ART3	Q13508	282	292	283	292	Repeat	Note=1
ART3	Q13508	302	312	293	302	Repeat	Note=2
ART3	Q13508	292	302	293	302	Repeat	Note=2
ART3	Q13508	302	312	293	302	Repeat	Note=2
ART3	Q13508	302	312	303	312	Repeat	Note=3
ART3	Q13508	302	312	303	312	Repeat	Note=3
ART3	Q13508	282	292	283	312	Region	Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H
ART3	Q13508	302	312	283	312	Region	Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H
ART3	Q13508	292	302	283	312	Region	Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H
ART3	Q13508	302	312	283	312	Region	Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H
ART3	Q13508	282	292	283	312	Region	Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H
ART3	Q13508	323	334	324	346	Alternative sequence	ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984
ART3	Q13508	334	345	324	346	Alternative sequence	ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984
ART3	Q13508	323	334	324	334	Alternative sequence	ID=VSP_003374;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ART3	Q13508	334	345	324	334	Alternative sequence	ID=VSP_003374;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NBEAL2	Q6ZNJ1	344	371	1	2754	Chain	ID=PRO_0000333254;Note=Neurobeachin-like protein 2
NBEAL2	Q6ZNJ1	1128	1181	1	2754	Chain	ID=PRO_0000333254;Note=Neurobeachin-like protein 2
NBEAL2	Q6ZNJ1	1594	1717	1	2754	Chain	ID=PRO_0000333254;Note=Neurobeachin-like protein 2
NBEAL2	Q6ZNJ1	2378	2408	1	2754	Chain	ID=PRO_0000333254;Note=Neurobeachin-like protein 2
NBEAL2	Q6ZNJ1	2534	2573	1	2754	Chain	ID=PRO_0000333254;Note=Neurobeachin-like protein 2
NBEAL2	Q6ZNJ1	2378	2408	2386	2424	Repeat	Note=WD 1
NBEAL2	Q6ZNJ1	2534	2573	2544	2582	Repeat	Note=WD 4
NBEAL2	Q6ZNJ1	1128	1181	1133	1267	Compositional bias	Note=Leu-rich
NBEAL2	Q6ZNJ1	1594	1717	1647	1647	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976;Dbxref=PMID:18669648,PMID:18691976
NBEAL2	Q6ZNJ1	1128	1181	1129	1181	Alternative sequence	ID=VSP_033505;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9628581;Dbxref=PMID:9628581
NBEAL2	Q6ZNJ1	2378	2408	2379	2408	Alternative sequence	ID=VSP_033507;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
NBEAL2	Q6ZNJ1	2534	2573	2553	2553	Natural variant	ID=VAR_066985;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21765411;Dbxref=dbSNP:rs144664865,PMID:21765411
CYB5RL	Q6IPT4	180	248	1	315	Chain	ID=PRO_0000337041;Note=NADH-cytochrome b5 reductase-like
CYB5RL	Q6IPT4	180	248	182	214	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
CYB5RL	Q6IPT4	180	248	180	247	Alternative sequence	ID=VSP_040404;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NDUFB9	Q9Y6M9	98	136	2	179	Chain	ID=PRO_0000174306;Note=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
NFS1	Q9Y697	136	187	136	186	Alternative sequence	ID=VSP_045860;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFS1	Q9Y697	69	108	71	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	69	108	98	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	136	187	127	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	136	187	142	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	136	187	148	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	136	187	157	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	136	187	172	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NFS1	Q9Y697	136	187	186	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WGB
NDUFA5	Q16718	61	83	2	116	Chain	ID=PRO_0000118632;Note=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
NDUFA5	Q16718	22	61	2	116	Chain	ID=PRO_0000118632;Note=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
NDUFA5	Q16718	7	22	2	116	Chain	ID=PRO_0000118632;Note=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
NDUFA5	Q16718	22	61	30	30	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NDUFA5	Q16718	22	61	46	46	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CPP6
NDUFA5	Q16718	22	61	60	60	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NDUFA5	Q16718	7	22	1	7	Alternative sequence	ID=VSP_055164;Note=In isoform 2. MAGVLKK->MPYRVGQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NDUFA5	Q16718	22	61	52	52	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NDUFA5	Q16718	7	22	11	13	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	22	61	20	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	7	22	20	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	61	83	43	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	22	61	43	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	61	83	65	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	61	83	77	79	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA5	Q16718	61	83	80	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	209	234	34	463	Chain	ID=PRO_0000019981;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2%2C mitochondrial
NDUFS2	O75306	234	260	34	463	Chain	ID=PRO_0000019981;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2%2C mitochondrial
NDUFS2	O75306	372	404	34	463	Chain	ID=PRO_0000019981;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2%2C mitochondrial
NDUFS2	O75306	209	234	224	224	Natural variant	ID=VAR_071891;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21057504;Dbxref=PMID:21057504
NDUFS2	O75306	209	234	228	228	Natural variant	ID=VAR_019535;Note=In MT-C1D. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11220739;Dbxref=dbSNP:rs121434427,PMID:11220739
NDUFS2	O75306	209	234	229	229	Natural variant	ID=VAR_034151;Note=P->A;Dbxref=dbSNP:rs16827493
NDUFS2	O75306	209	234	229	229	Natural variant	ID=VAR_019536;Note=In MT-C1D. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11220739;Dbxref=dbSNP:rs121434428,PMID:11220739
NDUFS2	O75306	209	234	198	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	209	234	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	209	234	231	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	234	260	231	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	234	260	240	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	234	260	251	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	234	260	260	264	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	372	404	375	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	372	404	385	387	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS2	O75306	372	404	393	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NEDD1	Q8NHV4	77	116	1	660	Chain	ID=PRO_0000051095;Note=Protein NEDD1
NEDD1	Q8NHV4	415	431	1	660	Chain	ID=PRO_0000051095;Note=Protein NEDD1
NEDD1	Q8NHV4	77	116	1	660	Chain	ID=PRO_0000051095;Note=Protein NEDD1
NEDD1	Q8NHV4	415	431	1	660	Chain	ID=PRO_0000051095;Note=Protein NEDD1
NEDD1	Q8NHV4	77	116	75	114	Repeat	Note=WD 3
NEDD1	Q8NHV4	77	116	75	114	Repeat	Note=WD 3
NEDD1	Q8NHV4	415	431	426	426	Modified residue	Note=Phosphoserine%3B by PLK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19509060;Dbxref=PMID:19509060
NEDD1	Q8NHV4	415	431	426	426	Modified residue	Note=Phosphoserine%3B by PLK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19509060;Dbxref=PMID:19509060
NEDD1	Q8NHV4	77	116	1	89	Alternative sequence	ID=VSP_043411;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEDD1	Q8NHV4	77	116	1	89	Alternative sequence	ID=VSP_043411;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NELFA	Q9H3P2	127	181	1	528	Chain	ID=PRO_0000219126;Note=Negative elongation factor A
NELFA	Q9H3P2	127	181	89	248	Domain	Note=HDAg;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01183
NELFA	Q9H3P2	127	181	125	188	Region	Note=NELF-C/D-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01183
NELFA	Q9H3P2	127	181	157	157	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:19690332,PMID:20068231,PMID:23186163
NELFA	Q9H3P2	127	181	1	263	Alternative sequence	ID=VSP_035589;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NELFA	Q9H3P2	127	181	115	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L3X
NELFA	Q9H3P2	127	181	139	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L3X
NELFA	Q9H3P2	127	181	146	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L3X
NELFA	Q9H3P2	127	181	163	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L3X
NELFA	Q9H3P2	127	181	171	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L3X
NF1	P21359	296	354	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	464	509	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	997	1037	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	1370	1391	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	1526	1574	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	2002	2049	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	2273	2307	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	2396	2440	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	2538	2579	2	2839	Chain	ID=PRO_0000010773;Note=Neurofibromin
NF1	P21359	296	354	2	1305	Chain	ID=PRO_0000010774;Note=Neurofibromin truncated
NF1	P21359	464	509	2	1305	Chain	ID=PRO_0000010774;Note=Neurofibromin truncated
NF1	P21359	997	1037	2	1305	Chain	ID=PRO_0000010774;Note=Neurofibromin truncated
NF1	P21359	1370	1391	1235	1451	Domain	Note=Ras-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00167
NF1	P21359	2538	2579	2555	2571	Motif	Note=Bipartite nuclear localization signal
NF1	P21359	2538	2579	2543	2543	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:21406692,PMID:23186163,PMID:24275569
NF1	P21359	2538	2579	2565	2565	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NF1	P21359	997	1037	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	1370	1391	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	1526	1574	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	2002	2049	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	2273	2307	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	2396	2440	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	2538	2579	552	2839	Alternative sequence	ID=VSP_001630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339276;Dbxref=PMID:1339276
NF1	P21359	997	1037	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	1370	1391	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	1526	1574	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	2002	2049	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	2273	2307	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	2396	2440	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	2538	2579	594	2839	Alternative sequence	ID=VSP_043468;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7570581;Dbxref=PMID:7570581
NF1	P21359	1370	1391	1371	1391	Alternative sequence	ID=VSP_001628;Note=In isoform 1 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1457041,ECO:0000303|PubMed:1783401,ECO:0000303|PubMed:1923522,ECO:0000303|PubMed:2114220,ECO:0000303|PubMed:2116237,ECO:0000303|PubMed:2134734;Dbxref=PMID:1457041,PMID:1783401,PMID:1923522,PMID:2114220,PMID:2116237,PMID:2134734
NF1	P21359	2002	2049	1599	2839	Alternative sequence	ID=VSP_001632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2121370;Dbxref=PMID:2121370
NF1	P21359	2273	2307	1599	2839	Alternative sequence	ID=VSP_001632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2121370;Dbxref=PMID:2121370
NF1	P21359	2396	2440	1599	2839	Alternative sequence	ID=VSP_001632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2121370;Dbxref=PMID:2121370
NF1	P21359	2538	2579	1599	2839	Alternative sequence	ID=VSP_001632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2121370;Dbxref=PMID:2121370
NF1	P21359	296	354	324	324	Natural variant	ID=VAR_032463;Note=In NF1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060124;Dbxref=dbSNP:rs199474735,PMID:15060124
NF1	P21359	296	354	330	330	Natural variant	ID=VAR_067201;Note=In a cutaneous neurofibroma from a patient with neurofibromatosis%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22108604;Dbxref=dbSNP:rs199474767,PMID:22108604
NF1	P21359	296	354	337	337	Natural variant	ID=VAR_032464;Note=In NF1. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060124;Dbxref=dbSNP:rs199474736,PMID:15060124
NF1	P21359	296	354	338	338	Natural variant	ID=VAR_010990;Note=In NF1. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9298829;Dbxref=dbSNP:rs199474773,PMID:9298829
NF1	P21359	464	509	489	489	Natural variant	ID=VAR_032465;Note=In NF1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060124;Dbxref=dbSNP:rs137854557,PMID:15060124
NF1	P21359	464	509	491	491	Natural variant	ID=VAR_021734;Note=In NF1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10712197;Dbxref=dbSNP:rs199474757,PMID:10712197
NF1	P21359	464	509	508	508	Natural variant	ID=VAR_010991;Note=In NF1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11258625;Dbxref=dbSNP:rs137854558,PMID:11258625
NF1	P21359	997	1037	1035	1035	Natural variant	ID=VAR_002657;Note=In NF1. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8807336;Dbxref=dbSNP:rs137854553,PMID:8807336
NF1	P21359	2002	2049	2012	2012	Natural variant	ID=VAR_021763;Note=In NF1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11735023;Dbxref=dbSNP:rs199474783,PMID:11735023
NF1	P21359	464	509	496	496	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NF1	P21359	464	509	496	496	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NF1	P21359	1370	1391	1361	1370	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF1
NF1	P21359	1526	1574	1535	1544	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF1
NF1	P21359	1526	1574	1569	1578	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P7Z
NFATC2IP	Q8NCF5	193	219	1	419	Chain	ID=PRO_0000281008;Note=NFATC2-interacting protein
NFATC2IP	Q8NCF5	193	219	209	231	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NFATC2IP	Q8NCF5	193	219	198	198	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NFATC2IP	Q8NCF5	193	219	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NFATC2IP	Q8NCF5	193	219	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
NFATC2IP	Q8NCF5	193	219	1	292	Alternative sequence	ID=VSP_023931;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
NFATC2IP	Q8NCF5	193	219	1	281	Alternative sequence	ID=VSP_023932;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM129A	Q9BZQ8	482	518	2	928	Chain	ID=PRO_0000213120;Note=Protein Niban
FAM129A	Q9BZQ8	445	482	2	928	Chain	ID=PRO_0000213120;Note=Protein Niban
FAM129A	Q9BZQ8	391	445	2	928	Chain	ID=PRO_0000213120;Note=Protein Niban
FAM129A	Q9BZQ8	239	274	2	928	Chain	ID=PRO_0000213120;Note=Protein Niban
FAM129A	Q9BZQ8	144	200	2	928	Chain	ID=PRO_0000213120;Note=Protein Niban
FAM129A	Q9BZQ8	62	106	2	928	Chain	ID=PRO_0000213120;Note=Protein Niban
FAM129A	Q9BZQ8	62	106	106	106	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NICN1	Q9BSH3	165	200	1	213	Chain	ID=PRO_0000096814;Note=Nicolin-1
NICN1	Q9BSH3	103	141	1	213	Chain	ID=PRO_0000096814;Note=Nicolin-1
NICN1	Q9BSH3	165	200	166	213	Alternative sequence	ID=VSP_011420;Note=In isoform 2. GLPDPSRVSSEVQQMWALTEMIRASHTSARIGRFDVDGCYDLNLLSYT->VSPHPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NID1	P14543	842	918	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	801	842	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	751	801	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	709	751	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	661	709	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	428	512	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	378	428	29	1247	Chain	ID=PRO_0000007669;Note=Nidogen-1
NID1	P14543	378	428	386	426	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	661	709	430	667	Domain	Note=Nidogen G2 beta-barrel;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00348
NID1	P14543	428	512	430	667	Domain	Note=Nidogen G2 beta-barrel;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00348
NID1	P14543	709	751	668	709	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	661	709	668	709	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	751	801	710	751	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	709	751	710	751	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	801	842	758	801	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	751	801	758	801	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	801	842	802	840	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID1	P14543	842	918	846	919	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
NID1	P14543	661	709	702	704	Motif	Note=Cell attachment site
NID1	P14543	378	428	390	403	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	378	428	397	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	428	512	411	618	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	378	428	411	618	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	378	428	414	425	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	661	709	672	685	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	661	709	679	695	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	661	709	697	708	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	709	751	714	727	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	709	751	721	736	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	709	751	738	750	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	751	801	762	777	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	751	801	769	787	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	751	801	789	800	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	801	842	806	817	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	801	842	811	826	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	801	842	828	839	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	842	918	849	878	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	842	918	889	896	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	842	918	898	919	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID1	P14543	842	918	710	842	Alternative sequence	ID=VSP_017254;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:15489334
NID1	P14543	801	842	710	842	Alternative sequence	ID=VSP_017254;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:15489334
NID1	P14543	751	801	710	842	Alternative sequence	ID=VSP_017254;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:15489334
NID1	P14543	709	751	710	842	Alternative sequence	ID=VSP_017254;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:15489334
NID1	P14543	378	428	387	387	Natural variant	ID=VAR_055763;Note=R->H;Dbxref=dbSNP:rs16833154
NID1	P14543	661	709	669	669	Natural variant	ID=VAR_021904;Note=Q->R;Dbxref=dbSNP:rs3738534
NID1	P14543	801	842	807	807	Natural variant	ID=VAR_058124;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs3738531
NID2	Q14112	931	1009	31	1375	Chain	ID=PRO_0000007671;Note=Nidogen-2
NID2	Q14112	843	891	31	1375	Chain	ID=PRO_0000007671;Note=Nidogen-2
NID2	Q14112	752	800	31	1375	Chain	ID=PRO_0000007671;Note=Nidogen-2
NID2	Q14112	752	800	528	758	Domain	Note=Nidogen G2 beta-barrel;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00348
NID2	Q14112	752	800	759	800	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID2	Q14112	843	891	801	843	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID2	Q14112	843	891	848	891	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NID2	Q14112	931	1009	937	1005	Domain	Note=Thyroglobulin type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
NID2	Q14112	752	800	763	776	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	752	800	770	786	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	752	800	788	799	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	843	891	852	867	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	843	891	859	877	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	843	891	879	890	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	931	1009	940	963	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	931	1009	974	981	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	931	1009	983	1005	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NID2	Q14112	843	891	844	892	Alternative sequence	ID=VSP_038780;Note=In isoform 2. LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTD->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NID2	Q14112	752	800	760	760	Natural variant	ID=VAR_062853;Note=G->V;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9733643,ECO:0000269|Ref.2,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2273430,PMID:24275569,PMID:14702039,PMID:9733643
NID2	Q14112	752	800	775	775	Natural variant	ID=VAR_055771;Note=R->Q;Dbxref=dbSNP:rs10134590
NID2	Q14112	843	891	866	866	Natural variant	ID=VAR_055773;Note=R->Q;Dbxref=dbSNP:rs28507587
NIPSNAP1	Q9BPW8	235	263	1	284	Chain	ID=PRO_0000221146;Note=Protein NipSnap homolog 1
NIPSNAP1	Q9BPW8	146	193	1	284	Chain	ID=PRO_0000221146;Note=Protein NipSnap homolog 1
NIPSNAP1	Q9BPW8	146	193	146	146	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NIPSNAP1	Q9BPW8	146	193	146	146	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55125
NIPSNAP1	Q9BPW8	146	193	191	191	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55125
NIPSNAP1	Q9BPW8	146	193	193	193	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55125
NIPSNAP1	Q9BPW8	146	193	193	193	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55125
NIPSNAP1	Q9BPW8	235	263	245	245	Natural variant	ID=VAR_011630;Note=E->K;Dbxref=dbSNP:rs1058646
NIPSNAP1	Q9BPW8	146	193	156	156	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	1	1024	Chain	ID=PRO_0000144087;Note=NLR family CARD domain-containing protein 4
NLRC4	Q9NPP4	0	87	1	1024	Chain	ID=PRO_0000144087;Note=NLR family CARD domain-containing protein 4
NLRC4	Q9NPP4	87	752	1	1024	Chain	ID=PRO_0000144087;Note=NLR family CARD domain-containing protein 4
NLRC4	Q9NPP4	0	87	1	1024	Chain	ID=PRO_0000144087;Note=NLR family CARD domain-containing protein 4
NLRC4	Q9NPP4	87	752	1	1024	Chain	ID=PRO_0000144087;Note=NLR family CARD domain-containing protein 4
NLRC4	Q9NPP4	0	87	1	1024	Chain	ID=PRO_0000144087;Note=NLR family CARD domain-containing protein 4
NLRC4	Q9NPP4	87	752	1	88	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
NLRC4	Q9NPP4	0	87	1	88	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
NLRC4	Q9NPP4	87	752	1	88	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
NLRC4	Q9NPP4	0	87	1	88	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
NLRC4	Q9NPP4	87	752	1	88	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
NLRC4	Q9NPP4	0	87	1	88	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
NLRC4	Q9NPP4	87	752	163	476	Domain	Note=NACHT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136
NLRC4	Q9NPP4	87	752	163	476	Domain	Note=NACHT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136
NLRC4	Q9NPP4	87	752	163	476	Domain	Note=NACHT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136
NLRC4	Q9NPP4	87	752	578	598	Repeat	Note=LRR 1
NLRC4	Q9NPP4	87	752	578	598	Repeat	Note=LRR 1
NLRC4	Q9NPP4	87	752	578	598	Repeat	Note=LRR 1
NLRC4	Q9NPP4	87	752	656	679	Repeat	Note=LRR 2
NLRC4	Q9NPP4	87	752	656	679	Repeat	Note=LRR 2
NLRC4	Q9NPP4	87	752	656	679	Repeat	Note=LRR 2
NLRC4	Q9NPP4	87	752	735	758	Repeat	Note=LRR 3
NLRC4	Q9NPP4	87	752	735	758	Repeat	Note=LRR 3
NLRC4	Q9NPP4	87	752	735	758	Repeat	Note=LRR 3
NLRC4	Q9NPP4	87	752	169	176	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136
NLRC4	Q9NPP4	87	752	169	176	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136
NLRC4	Q9NPP4	87	752	169	176	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00136
NLRC4	Q9NPP4	87	752	95	298	Region	Note=Nucleotide-binding domain (NBD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NLRC4	Q9NPP4	87	752	95	298	Region	Note=Nucleotide-binding domain (NBD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NLRC4	Q9NPP4	87	752	95	298	Region	Note=Nucleotide-binding domain (NBD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NLRC4	Q9NPP4	87	752	356	463	Region	Note=Winged-helix domain (WHD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NLRC4	Q9NPP4	87	752	356	463	Region	Note=Winged-helix domain (WHD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NLRC4	Q9NPP4	87	752	356	463	Region	Note=Winged-helix domain (WHD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NLRC4	Q9NPP4	87	752	533	533	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UP24
NLRC4	Q9NPP4	87	752	533	533	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UP24
NLRC4	Q9NPP4	87	752	533	533	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UP24
NLRC4	Q9NPP4	87	752	89	753	Alternative sequence	ID=VSP_000784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	89	753	Alternative sequence	ID=VSP_000784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	89	753	Alternative sequence	ID=VSP_000784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	90	92	Alternative sequence	ID=VSP_000787;Note=In isoform 4. FHQ->LTA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	90	92	Alternative sequence	ID=VSP_000787;Note=In isoform 4. FHQ->LTA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	90	92	Alternative sequence	ID=VSP_000787;Note=In isoform 4. FHQ->LTA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	93	1024	Alternative sequence	ID=VSP_000788;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	93	1024	Alternative sequence	ID=VSP_000788;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	93	1024	Alternative sequence	ID=VSP_000788;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	155	156	Alternative sequence	ID=VSP_000785;Note=In isoform 3. NG->VL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	155	156	Alternative sequence	ID=VSP_000785;Note=In isoform 3. NG->VL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	155	156	Alternative sequence	ID=VSP_000785;Note=In isoform 3. NG->VL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	157	1024	Alternative sequence	ID=VSP_000786;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	157	1024	Alternative sequence	ID=VSP_000786;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	157	1024	Alternative sequence	ID=VSP_000786;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11472070;Dbxref=PMID:11472070
NLRC4	Q9NPP4	87	752	337	337	Natural variant	ID=VAR_072484;Note=In AIFEC%3B results in a gain of function mutation with constitutive activation of caspase-1. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25217959;Dbxref=dbSNP:rs587777840,PMID:25217959
NLRC4	Q9NPP4	87	752	337	337	Natural variant	ID=VAR_072484;Note=In AIFEC%3B results in a gain of function mutation with constitutive activation of caspase-1. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25217959;Dbxref=dbSNP:rs587777840,PMID:25217959
NLRC4	Q9NPP4	87	752	337	337	Natural variant	ID=VAR_072484;Note=In AIFEC%3B results in a gain of function mutation with constitutive activation of caspase-1. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25217959;Dbxref=dbSNP:rs587777840,PMID:25217959
NLRC4	Q9NPP4	87	752	341	341	Natural variant	ID=VAR_072485;Note=In AIFEC%3B results in a gain of function mutation with constitutive activation of caspase-1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25217960;Dbxref=dbSNP:rs587781260,PMID:25217960
NLRC4	Q9NPP4	87	752	341	341	Natural variant	ID=VAR_072485;Note=In AIFEC%3B results in a gain of function mutation with constitutive activation of caspase-1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25217960;Dbxref=dbSNP:rs587781260,PMID:25217960
NLRC4	Q9NPP4	87	752	341	341	Natural variant	ID=VAR_072485;Note=In AIFEC%3B results in a gain of function mutation with constitutive activation of caspase-1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25217960;Dbxref=dbSNP:rs587781260,PMID:25217960
NLRC4	Q9NPP4	87	752	443	443	Natural variant	ID=VAR_072645;Note=In FCAS4%3B the mutation increases oligomerization of the NLRC4 protein%3B results in hyperactivation of caspase-1 with an increase in IL1B protein secretion. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25385754;Dbxref=dbSNP:rs606231460,PMID:25385754
NLRC4	Q9NPP4	87	752	443	443	Natural variant	ID=VAR_072645;Note=In FCAS4%3B the mutation increases oligomerization of the NLRC4 protein%3B results in hyperactivation of caspase-1 with an increase in IL1B protein secretion. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25385754;Dbxref=dbSNP:rs606231460,PMID:25385754
NLRC4	Q9NPP4	87	752	443	443	Natural variant	ID=VAR_072645;Note=In FCAS4%3B the mutation increases oligomerization of the NLRC4 protein%3B results in hyperactivation of caspase-1 with an increase in IL1B protein secretion. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25385754;Dbxref=dbSNP:rs606231460,PMID:25385754
NLRC4	Q9NPP4	0	87	39	39	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	0	87	39	39	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	0	87	39	39	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	138	138	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	138	138	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	138	138	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	393	393	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	393	393	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	393	393	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	420	420	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	420	420	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	420	420	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	678	678	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	678	678	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NLRC4	Q9NPP4	87	752	678	678	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
LCN12	Q6JVE5	110	149	20	192	Chain	ID=PRO_0000017922;Note=Epididymal-specific lipocalin-12
LCN12	Q6JVE5	110	149	88	192	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CD58	P19256	121	209	29	250	Chain	ID=PRO_0000014814;Note=Lymphocyte function-associated antigen 3
CD58	P19256	121	209	29	215	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD58	P19256	121	209	30	121	Domain	Note=Ig-like
CD58	P19256	121	209	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD58	P19256	121	209	169	169	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD58	P19256	121	209	195	195	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD58	P19256	121	209	142	187	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CD58	P19256	121	209	121	121	Mutagenesis	Note=No effect on CD2-binding. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10380930;Dbxref=PMID:10380930
CD58	P19256	121	209	114	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CCZ
CD58	P19256	121	209	128	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CCZ
CD58	P19256	121	209	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CCZ
CD58	P19256	121	209	146	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CCZ
CD58	P19256	121	209	165	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CCZ
CD58	P19256	121	209	172	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CCZ
FAIM2	Q9BWQ8	249	267	1	316	Chain	ID=PRO_0000179087;Note=Protein lifeguard 2
FAIM2	Q9BWQ8	249	267	250	270	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	778	832	45	1097	Chain	ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor
LIFR	P42702	688	722	45	1097	Chain	ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor
LIFR	P42702	778	832	45	1097	Chain	ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor
LIFR	P42702	688	722	45	1097	Chain	ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor
LIFR	P42702	778	832	45	833	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	688	722	45	833	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	778	832	45	833	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	688	722	45	833	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	688	722	627	719	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
LIFR	P42702	688	722	627	719	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
LIFR	P42702	778	832	724	833	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
LIFR	P42702	778	832	724	833	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
LIFR	P42702	778	832	787	787	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	778	832	787	787	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIFR	P42702	778	832	785	785	Natural variant	ID=VAR_029111;Note=V->I;Dbxref=dbSNP:rs3110234
LIFR	P42702	778	832	785	785	Natural variant	ID=VAR_029111;Note=V->I;Dbxref=dbSNP:rs3110234
LTA4H	P09960	478	510	2	611	Chain	ID=PRO_0000095124;Note=Leukotriene A-4 hydrolase
LTA4H	P09960	137	160	2	611	Chain	ID=PRO_0000095124;Note=Leukotriene A-4 hydrolase
LTA4H	P09960	137	160	135	137	Region	Note=Substrate binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18804029;Dbxref=PMID:18804029
LTA4H	P09960	137	160	137	137	Mutagenesis	Note=No loss of activity. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11675384;Dbxref=PMID:11675384
LTA4H	P09960	137	160	137	137	Mutagenesis	Note=Aminopeptidase activity strongly impaired%2C but keeps LTA4 activity. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11675384;Dbxref=PMID:11675384
LTA4H	P09960	137	160	137	137	Mutagenesis	Note=Aminopeptidase activity almost absent%2C but keeps LTA4 activity. Q->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11675384;Dbxref=PMID:11675384
LTA4H	P09960	137	160	140	140	Mutagenesis	Note=Aminopeptidase activity almost absent%2C but keeps LTA4 activity. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11917124;Dbxref=PMID:11917124
LTA4H	P09960	137	160	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
LTA4H	P09960	137	160	141	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
LTA4H	P09960	137	160	155	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
LTA4H	P09960	478	510	467	478	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
LTA4H	P09960	478	510	481	486	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
LTA4H	P09960	478	510	489	492	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
LTA4H	P09960	478	510	497	508	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U9W
MTX1	Q13505	226	257	1	466	Chain	ID=PRO_0000220991;Note=Metaxin-1
MTX1	Q13505	226	257	227	227	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
MTX1	Q13505	226	257	227	257	Alternative sequence	ID=VSP_035742;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LRRC49	Q8IUZ0	189	237	1	686	Chain	ID=PRO_0000233034;Note=Leucine-rich repeat-containing protein 49
LRRC49	Q8IUZ0	307	335	1	686	Chain	ID=PRO_0000233034;Note=Leucine-rich repeat-containing protein 49
LRRC49	Q8IUZ0	189	237	179	200	Repeat	Note=LRR 4
LRRC49	Q8IUZ0	189	237	201	222	Repeat	Note=LRR 5
LRRC49	Q8IUZ0	189	237	223	244	Repeat	Note=LRR 6
LRRC49	Q8IUZ0	307	335	279	317	Domain	Note=LRRCT
LRRC49	Q8IUZ0	307	335	303	341	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRCH1	Q9Y2L9	438	466	1	728	Chain	ID=PRO_0000084478;Note=Leucine-rich repeat and calponin homology domain-containing protein 1
LRCH1	Q9Y2L9	467	496	1	728	Chain	ID=PRO_0000084478;Note=Leucine-rich repeat and calponin homology domain-containing protein 1
LRCH1	Q9Y2L9	467	496	486	486	Natural variant	ID=VAR_051134;Note=A->S;Dbxref=dbSNP:rs11617392
LRRC59	Q96AG4	55	108	1	307	Chain	ID=PRO_0000235159;Note=Leucine-rich repeat-containing protein 59
LRRC59	Q96AG4	35	55	1	307	Chain	ID=PRO_0000235159;Note=Leucine-rich repeat-containing protein 59
LRRC59	Q96AG4	55	108	2	307	Chain	ID=PRO_0000441739;Note=Leucine-rich repeat-containing protein 59%2C N-terminally processed
LRRC59	Q96AG4	35	55	2	307	Chain	ID=PRO_0000441739;Note=Leucine-rich repeat-containing protein 59%2C N-terminally processed
LRRC59	Q96AG4	55	108	1	244	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC59	Q96AG4	35	55	1	244	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC59	Q96AG4	55	108	40	62	Repeat	Note=LRR 2
LRRC59	Q96AG4	35	55	40	62	Repeat	Note=LRR 2
LRRC59	Q96AG4	55	108	63	84	Repeat	Note=LRR 3
LRRC59	Q96AG4	55	108	86	107	Repeat	Note=LRR 4
LRRC59	Q96AG4	55	108	73	73	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q922Q8
LRRIQ3	A6PVS8	83	191	1	624	Chain	ID=PRO_0000311194;Note=Leucine-rich repeat and IQ domain-containing protein 3
LRRIQ3	A6PVS8	83	191	1	624	Chain	ID=PRO_0000311194;Note=Leucine-rich repeat and IQ domain-containing protein 3
LRRIQ3	A6PVS8	83	191	73	94	Repeat	Note=LRR 2
LRRIQ3	A6PVS8	83	191	73	94	Repeat	Note=LRR 2
LRRIQ3	A6PVS8	83	191	98	119	Repeat	Note=LRR 3
LRRIQ3	A6PVS8	83	191	98	119	Repeat	Note=LRR 3
LRRIQ3	A6PVS8	83	191	132	179	Domain	Note=LRRCT
LRRIQ3	A6PVS8	83	191	132	179	Domain	Note=LRRCT
LRRIQ3	A6PVS8	83	191	129	129	Natural variant	ID=VAR_037155;Note=M->I;Dbxref=dbSNP:rs17094900
LRRIQ3	A6PVS8	83	191	129	129	Natural variant	ID=VAR_037155;Note=M->I;Dbxref=dbSNP:rs17094900
LRRIQ3	A6PVS8	83	191	156	156	Natural variant	ID=VAR_037156;Note=H->Y;Dbxref=dbSNP:rs17591320
LRRIQ3	A6PVS8	83	191	156	156	Natural variant	ID=VAR_037156;Note=H->Y;Dbxref=dbSNP:rs17591320
LRP12	Q9Y561	26	45	1	32	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP12	Q9Y561	26	45	33	859	Chain	ID=PRO_0000017339;Note=Low-density lipoprotein receptor-related protein 12
LRP12	Q9Y561	26	45	33	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRP12	Q9Y561	26	45	27	45	Alternative sequence	ID=VSP_040992;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP3K11	Q16584	610	735	1	847	Chain	ID=PRO_0000086260;Note=Mitogen-activated protein kinase kinase kinase 11
MAP3K11	Q16584	496	534	1	847	Chain	ID=PRO_0000086260;Note=Mitogen-activated protein kinase kinase kinase 11
MAP3K11	Q16584	496	534	426	514	Compositional bias	Note=Arg-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAP3K11	Q16584	610	735	599	825	Compositional bias	Note=Pro-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAP3K11	Q16584	496	534	507	507	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18691976,PMID:19369195,PMID:23186163
MAP3K11	Q16584	496	534	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:11969422;Dbxref=PMID:23186163,PMID:11969422
MAP3K11	Q16584	610	735	654	654	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11969422;Dbxref=PMID:11969422
MAP3K11	Q16584	610	735	693	693	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
MAP3K11	Q16584	610	735	705	705	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:11969422;Dbxref=PMID:18691976,PMID:19369195,PMID:11969422
MAP3K11	Q16584	610	735	708	708	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
MAP3K11	Q16584	610	735	724	724	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11969422;Dbxref=PMID:11969422
MAP3K11	Q16584	610	735	727	727	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11969422;Dbxref=PMID:11969422
MAP3K4	Q9Y6R4	569	650	1	1608	Chain	ID=PRO_0000086247;Note=Mitogen-activated protein kinase kinase kinase 4
MAP3K4	Q9Y6R4	941	991	1	1608	Chain	ID=PRO_0000086247;Note=Mitogen-activated protein kinase kinase kinase 4
MAP3K4	Q9Y6R4	1175	1224	1	1608	Chain	ID=PRO_0000086247;Note=Mitogen-activated protein kinase kinase kinase 4
MAP3K4	Q9Y6R4	1175	1224	1190	1202	Compositional bias	Note=Poly-Ala
MAP3K4	Q9Y6R4	1175	1224	1175	1224	Alternative sequence	ID=VSP_004884;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9039502;Dbxref=PMID:15489334,PMID:9039502
MAP3K4	Q9Y6R4	569	650	584	584	Natural variant	ID=VAR_040689;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34018542,PMID:17344846
MAP3K4	Q9Y6R4	1175	1224	1190	1190	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K4	Q9Y6R4	1175	1224	1190	1190	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K4	Q9Y6R4	1175	1224	1190	1190	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K4	Q9Y6R4	1175	1224	1199	1199	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAN1A2	O60476	258	285	2	641	Chain	ID=PRO_0000210312;Note=Mannosyl-oligosaccharide 1%2C2-alpha-mannosidase IB
MAN1A2	O60476	258	285	58	641	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAN2A1	Q16706	776	817	1	1144	Chain	ID=PRO_0000206902;Note=Alpha-mannosidase 2
MAN2A1	Q16706	776	817	27	1144	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAPKAPK3	Q16644	305	332	1	382	Chain	ID=PRO_0000086293;Note=MAP kinase-activated protein kinase 3
MAPKAPK3	Q16644	305	332	1	382	Chain	ID=PRO_0000086293;Note=MAP kinase-activated protein kinase 3
MAPKAPK3	Q16644	305	332	307	343	Region	Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK3	Q16644	305	332	307	343	Region	Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK3	Q16644	305	332	307	307	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK3	Q16644	305	332	307	307	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK3	Q16644	305	332	313	313	Modified residue	Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK3	Q16644	305	332	313	313	Modified residue	Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000250;evidence=ECO:0000250
MAPKAPK3	Q16644	305	332	302	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	302	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	317	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	317	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	325	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	325	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	328	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MAPKAPK3	Q16644	305	332	328	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR
MARCH2	Q9P0N8	124	194	1	246	Chain	ID=PRO_0000055925;Note=E3 ubiquitin-protein ligase MARCH2
MARCH2	Q9P0N8	124	194	1	246	Chain	ID=PRO_0000055925;Note=E3 ubiquitin-protein ligase MARCH2
MARCH2	Q9P0N8	124	194	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARCH2	Q9P0N8	124	194	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARCH2	Q9P0N8	124	194	175	195	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARCH2	Q9P0N8	124	194	175	195	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARCH2	Q9P0N8	124	194	125	194	Alternative sequence	ID=VSP_041478;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARCH2	Q9P0N8	124	194	125	194	Alternative sequence	ID=VSP_041478;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARCH3	Q86UD3	131	201	1	253	Chain	ID=PRO_0000055927;Note=E3 ubiquitin-protein ligase MARCH3
MARCH3	Q86UD3	131	201	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARCH3	Q86UD3	131	201	182	202	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARCH3	Q86UD3	131	201	132	138	Alternative sequence	ID=VSP_055451;Note=In isoform 2. WLRNPGP->VSKWGTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MARCH3	Q86UD3	131	201	139	253	Alternative sequence	ID=VSP_055452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MBD6	Q96DN6	126	473	1	1003	Chain	ID=PRO_0000096267;Note=Methyl-CpG-binding domain protein 6
MBD6	Q96DN6	126	473	140	846	Compositional bias	Note=Pro-rich
MBNL1	Q9NR56	58	115	1	388	Chain	ID=PRO_0000089178;Note=Muscleblind-like protein 1
MBNL1	Q9NR56	115	183	1	388	Chain	ID=PRO_0000089178;Note=Muscleblind-like protein 1
MBNL1	Q9NR56	269	287	1	388	Chain	ID=PRO_0000089178;Note=Muscleblind-like protein 1
MBNL1	Q9NR56	58	115	1	388	Chain	ID=PRO_0000089178;Note=Muscleblind-like protein 1
MBNL1	Q9NR56	115	183	1	388	Chain	ID=PRO_0000089178;Note=Muscleblind-like protein 1
MBNL1	Q9NR56	269	287	1	388	Chain	ID=PRO_0000089178;Note=Muscleblind-like protein 1
MBNL1	Q9NR56	58	115	47	73	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL1	Q9NR56	58	115	47	73	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL1	Q9NR56	115	183	179	207	Zinc finger	Note=C3H1-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL1	Q9NR56	115	183	179	207	Zinc finger	Note=C3H1-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL1	Q9NR56	115	183	116	183	Alternative sequence	ID=VSP_006429;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10970838;Dbxref=PMID:10970838
MBNL1	Q9NR56	115	183	116	183	Alternative sequence	ID=VSP_006429;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10970838;Dbxref=PMID:10970838
MBNL1	Q9NR56	269	287	270	370	Alternative sequence	ID=VSP_044903;Note=In isoform 7. TQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTSATSVPFAATATANQ->FPWCTVLRQPLCPQQQHLPQVFPSLQQPQPTSPILDASTLLGATSCPAAAGKM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
MBNL1	Q9NR56	269	287	270	370	Alternative sequence	ID=VSP_044903;Note=In isoform 7. TQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTSATSVPFAATATANQ->FPWCTVLRQPLCPQQQHLPQVFPSLQQPQPTSPILDASTLLGATSCPAAAGKM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
MBNL1	Q9NR56	269	287	270	287	Alternative sequence	ID=VSP_006430;Note=In isoform 2%2C isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10970838,ECO:0000303|PubMed:11590133,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455477,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:10970838,PMID:11590133,PMID:15489334,PMID:9455477
MBNL1	Q9NR56	269	287	270	287	Alternative sequence	ID=VSP_006430;Note=In isoform 2%2C isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10970838,ECO:0000303|PubMed:11590133,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455477,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:10970838,PMID:11590133,PMID:15489334,PMID:9455477
MBNL1	Q9NR56	115	183	171	173	Natural variant	ID=VAR_076509;Note=In DM1%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27222292;Dbxref=PMID:27222292
MBNL1	Q9NR56	115	183	171	173	Natural variant	ID=VAR_076509;Note=In DM1%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27222292;Dbxref=PMID:27222292
MBNL1	Q9NR56	58	115	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6H
MBNL1	Q9NR56	58	115	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6H
MBNL1	Q9NR56	58	115	73	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D2N
MBNL1	Q9NR56	58	115	73	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D2N
MBNL1	Q9NR56	58	115	89	91	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U9B
MBNL1	Q9NR56	58	115	89	91	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U9B
MBNL1	Q9NR56	115	183	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6L
MBNL1	Q9NR56	115	183	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6L
MBNL1	Q9NR56	115	183	181	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D2Q
MBNL1	Q9NR56	115	183	181	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D2Q
LPCAT3	Q6P1A2	50	86	2	487	Chain	ID=PRO_0000233382;Note=Lysophospholipid acyltransferase 5
LPCAT3	Q6P1A2	50	86	44	64	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPCAT3	Q6P1A2	50	86	84	104	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LPCAT3	Q6P1A2	50	86	21	100	Alternative sequence	ID=VSP_053680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LPCAT3	Q6P1A2	50	86	63	63	Natural variant	ID=VAR_050027;Note=F->L;Dbxref=dbSNP:rs34196984
MYT1	Q01538	430	475	1	1121	Chain	ID=PRO_0000096676;Note=Myelin transcription factor 1
MYT1	Q01538	820	842	1	1121	Chain	ID=PRO_0000096676;Note=Myelin transcription factor 1
MYT1	Q01538	430	475	433	476	Zinc finger	Note=CCHHC-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
MYT1	Q01538	820	842	791	834	Zinc finger	Note=CCHHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
MYT1	Q01538	820	842	835	878	Zinc finger	Note=CCHHC-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
MYT1	Q01538	820	842	837	837	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
MECR	Q9BV79	135	183	54	373	Chain	ID=PRO_0000000888;Note=Enoyl-[acyl-carrier-protein] reductase%2C mitochondrial
MECR	Q9BV79	135	183	167	167	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8WZM3
MECR	Q9BV79	135	183	165	165	Mutagenesis	Note=Strongly increases activity with trans-oct-2-enoyl-CoA. Decreases activity with trans-tetradec-2-enoyl-CoA by 73%25. Decreases activity with trans-hexadec-2-enoyl-CoA by 80%25. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18479707;Dbxref=PMID:18479707
MECR	Q9BV79	135	183	170	170	Mutagenesis	Note=Reduces catalytic activity by 69%25. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18479707;Dbxref=PMID:18479707
MECR	Q9BV79	135	183	138	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSY
MECR	Q9BV79	135	183	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSY
MECR	Q9BV79	135	183	149	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSY
MECR	Q9BV79	135	183	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSY
MECR	Q9BV79	135	183	158	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSY
MECR	Q9BV79	135	183	167	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSY
MEP1B	Q16820	182	255	62	701	Chain	ID=PRO_0000028884;Note=Meprin A subunit beta
MEP1B	Q16820	182	255	23	652	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEP1B	Q16820	182	255	62	256	Domain	Note=Peptidase M12A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01211
MEP1B	Q16820	182	255	238	238	Site	Note=Mediates preference for acidic residues at subsite P1'
MEP1B	Q16820	182	255	218	218	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22988105;Dbxref=PMID:22988105
MEP1B	Q16820	182	255	254	254	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22988105;Dbxref=PMID:22988105
MEP1B	Q16820	182	255	103	255	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01211,ECO:0000269|PubMed:22988105;Dbxref=PMID:22988105
MEP1B	Q16820	182	255	248	248	Mutagenesis	Note=Decreased activity toward gastrin. K->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12888571;Dbxref=PMID:12888571
MEP1B	Q16820	182	255	185	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MEP1B	Q16820	182	255	193	195	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWN
MEP1B	Q16820	182	255	213	216	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MEP1B	Q16820	182	255	217	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MEP1B	Q16820	182	255	223	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MEP1B	Q16820	182	255	229	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MEP1B	Q16820	182	255	232	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MEP1B	Q16820	182	255	243	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWM
MBTPS1	Q14703	54	140	18	186	Propeptide	ID=PRO_0000027051
MBTPS1	Q14703	857	901	187	1052	Chain	ID=PRO_0000027052;Note=Membrane-bound transcription factor site-1 protease
MBTPS1	Q14703	531	594	187	1052	Chain	ID=PRO_0000027052;Note=Membrane-bound transcription factor site-1 protease
MBTPS1	Q14703	857	901	187	998	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MBTPS1	Q14703	531	594	187	998	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MBTPS1	Q14703	54	140	90	90	Natural variant	ID=VAR_051823;Note=R->G;Dbxref=dbSNP:rs34076105
MDM4	O15151	26	51	1	490	Chain	ID=PRO_0000157336;Note=Protein Mdm4
MDM4	O15151	224	274	1	490	Chain	ID=PRO_0000157336;Note=Protein Mdm4
MDM4	O15151	26	51	26	106	Domain	Note=SWIB
MDM4	O15151	224	274	246	332	Region	Note=Region II
MDM4	O15151	224	274	243	308	Compositional bias	Note=Asp/Glu-rich (acidic)
MDM4	O15151	26	51	27	352	Alternative sequence	ID=VSP_042563;Note=In isoform HDMX211. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16266988;Dbxref=PMID:16266988
MDM4	O15151	224	274	27	352	Alternative sequence	ID=VSP_042563;Note=In isoform HDMX211. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16266988;Dbxref=PMID:16266988
MDM4	O15151	224	274	109	490	Alternative sequence	ID=VSP_035669;Note=In isoform 2. LATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA->SASNNTARCNRILQSQKKN;Ontology_term=ECO:0000305;evidence=ECO:0000305
MDM4	O15151	224	274	109	490	Alternative sequence	ID=VSP_035670;Note=In isoform 3. LATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA->SASNNTDAAQTLALAQDHT;Ontology_term=ECO:0000305;evidence=ECO:0000305
MDM4	O15151	224	274	225	274	Alternative sequence	ID=VSP_043145;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MDM4	O15151	26	51	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FEA
MDM4	O15151	26	51	31	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FEA
MDM4	O15151	26	51	49	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FEA
MFAP5	Q13361	19	31	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
MFAP5	Q13361	57	72	22	173	Chain	ID=PRO_0000018685;Note=Microfibrillar-associated protein 5
MFAP5	Q13361	46	57	22	173	Chain	ID=PRO_0000018685;Note=Microfibrillar-associated protein 5
MFAP5	Q13361	19	31	22	173	Chain	ID=PRO_0000018685;Note=Microfibrillar-associated protein 5
MFAP5	Q13361	19	31	30	32	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFAP5	Q13361	46	57	54	54	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22171320;Dbxref=PMID:22171320
MFAP5	Q13361	19	31	21	21	Natural variant	ID=VAR_072688;Note=In AAT9%3B expression of the mutant protein is significantly decreased. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25434006;Dbxref=dbSNP:rs724159961,PMID:25434006
MFAP5	Q13361	57	72	61	61	Natural variant	ID=VAR_036430;Note=In a breast cancer sample%3B somatic mutation. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SLC25A28	Q96A46	173	192	1	364	Chain	ID=PRO_0000235255;Note=Mitoferrin-2
SLC25A28	Q96A46	173	192	170	189	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A28	Q96A46	173	192	168	252	Repeat	Note=Solcar 2
SLC25A28	Q96A46	173	192	1	188	Alternative sequence	ID=VSP_018413;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.2;Dbxref=PMID:17974005
SLC25A28	Q96A46	173	192	1	187	Alternative sequence	ID=VSP_018414;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11297739;Dbxref=PMID:11297739
SLC25A28	Q96A46	173	192	189	192	Alternative sequence	ID=VSP_018415;Note=In isoform 3. NPAE->MALL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.2;Dbxref=PMID:17974005
MFSD12	Q6NUT3	341	398	1	480	Chain	ID=PRO_0000274522;Note=Major facilitator superfamily domain-containing protein 12
MFSD12	Q6NUT3	279	310	1	480	Chain	ID=PRO_0000274522;Note=Major facilitator superfamily domain-containing protein 12
MFSD12	Q6NUT3	279	310	280	302	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD12	Q6NUT3	341	398	348	368	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD12	Q6NUT3	341	398	369	389	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD12	Q6NUT3	341	398	395	395	Natural variant	ID=VAR_050301;Note=G->S;Dbxref=dbSNP:rs34878396
MGAT5B	Q3V5L5	173	230	1	792	Chain	ID=PRO_0000288611;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
MGAT5B	Q3V5L5	173	230	46	792	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MKRN2	Q9H000	286	322	1	416	Chain	ID=PRO_0000055955;Note=Probable E3 ubiquitin-protein ligase makorin-2
MKRN2	Q9H000	286	322	238	292	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
MKRN2	Q9H000	286	322	321	350	Zinc finger	Note=C3H1-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MITD1	Q8WV92	130	159	1	249	Chain	ID=PRO_0000260495;Note=MIT domain-containing protein 1
MITD1	Q8WV92	50	84	1	249	Chain	ID=PRO_0000260495;Note=MIT domain-containing protein 1
MITD1	Q8WV92	50	84	8	86	Domain	Note=MIT
MITD1	Q8WV92	50	84	69	69	Mutagenesis	Note=Abolishes interaction with CHMP1A%2C CHMP1B and CHMP2A. M->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23045692;Dbxref=PMID:23045692
MITD1	Q8WV92	50	84	73	73	Mutagenesis	Note=Abolishes interaction with CHMP1A%2C CHMP1B and CHMP2A. Abolishes location at the midbody. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23045692;Dbxref=PMID:23045692
MITD1	Q8WV92	130	159	132	132	Mutagenesis	Note=Abolishes homodimerization%3B when associated with A-221 and A-225. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23045692;Dbxref=PMID:23045692
MITD1	Q8WV92	50	84	84	84	Sequence conflict	Note=E->EGK;Ontology_term=ECO:0000305;evidence=ECO:0000305
MITD1	Q8WV92	130	159	130	130	Sequence conflict	Note=Q->QV;Ontology_term=ECO:0000305;evidence=ECO:0000305
MITD1	Q8WV92	50	84	31	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5X
MITD1	Q8WV92	50	84	55	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5X
MITD1	Q8WV92	130	159	128	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5Z
MITD1	Q8WV92	130	159	150	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5Z
TMEM67	Q5HYA8	506	525	36	995	Chain	ID=PRO_0000225689;Note=Meckelin;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM67	Q5HYA8	525	558	36	995	Chain	ID=PRO_0000225689;Note=Meckelin;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM67	Q5HYA8	558	591	36	995	Chain	ID=PRO_0000225689;Note=Meckelin;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM67	Q5HYA8	774	813	36	995	Chain	ID=PRO_0000225689;Note=Meckelin;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM67	Q5HYA8	525	558	526	546	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM67	Q5HYA8	558	591	570	590	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM67	Q5HYA8	506	525	513	513	Natural variant	ID=VAR_031987;Note=In JBTS6%2C MKS3 and COACHS. Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17160906,ECO:0000269|PubMed:19466712,ECO:0000269|PubMed:19574260;Dbxref=dbSNP:rs137853107,PMID:17160906,PMID:19466712,PMID:19574260
TMEM67	Q5HYA8	525	558	545	545	Natural variant	ID=VAR_031988;Note=In JBTS6. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17160906;Dbxref=dbSNP:rs267607114,PMID:17160906
TMEM67	Q5HYA8	558	591	569	569	Natural variant	ID=VAR_076875;Note=Probable disease-associated disorder found in Joubert syndrome-related disorder. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20232449;Dbxref=dbSNP:rs1017800436,PMID:20232449
TMEM67	Q5HYA8	558	591	590	590	Natural variant	ID=VAR_063796;Note=In COACHS. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058225;Dbxref=dbSNP:rs267607115,PMID:19058225
TMEM67	Q5HYA8	774	813	782	782	Natural variant	ID=VAR_063799;Note=In COACHS. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058225;Dbxref=dbSNP:rs777137476,PMID:19058225
TMEM67	Q5HYA8	774	813	786	786	Natural variant	ID=VAR_076879;Note=In MKS3. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20232449;Dbxref=dbSNP:rs386834193,PMID:20232449
MDK	P21741	25	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	81	135	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	25	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	81	135	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	25	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	81	135	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	25	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	81	135	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	25	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	81	135	21	143	Chain	ID=PRO_0000024662;Note=Midkine
MDK	P21741	25	81	37	61	Disulfide bond	.
MDK	P21741	25	81	37	61	Disulfide bond	.
MDK	P21741	25	81	37	61	Disulfide bond	.
MDK	P21741	25	81	37	61	Disulfide bond	.
MDK	P21741	25	81	37	61	Disulfide bond	.
MDK	P21741	25	81	45	70	Disulfide bond	.
MDK	P21741	25	81	45	70	Disulfide bond	.
MDK	P21741	25	81	45	70	Disulfide bond	.
MDK	P21741	25	81	45	70	Disulfide bond	.
MDK	P21741	25	81	45	70	Disulfide bond	.
MDK	P21741	25	81	52	74	Disulfide bond	.
MDK	P21741	25	81	52	74	Disulfide bond	.
MDK	P21741	25	81	52	74	Disulfide bond	.
MDK	P21741	25	81	52	74	Disulfide bond	.
MDK	P21741	25	81	52	74	Disulfide bond	.
MDK	P21741	81	135	84	116	Disulfide bond	.
MDK	P21741	81	135	84	116	Disulfide bond	.
MDK	P21741	81	135	84	116	Disulfide bond	.
MDK	P21741	81	135	84	116	Disulfide bond	.
MDK	P21741	81	135	84	116	Disulfide bond	.
MDK	P21741	81	135	94	126	Disulfide bond	.
MDK	P21741	81	135	94	126	Disulfide bond	.
MDK	P21741	81	135	94	126	Disulfide bond	.
MDK	P21741	81	135	94	126	Disulfide bond	.
MDK	P21741	81	135	94	126	Disulfide bond	.
MDK	P21741	25	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	81	135	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	25	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	81	135	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	25	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	81	135	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	25	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	81	135	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	25	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	81	135	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
MDK	P21741	25	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	25	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
MDK	P21741	81	135	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	111	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	111	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	111	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	111	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	111	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MDK	P21741	81	135	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKC
MMP17	Q9ULZ9	350	401	126	565	Chain	ID=PRO_0000028819;Note=Matrix metalloproteinase-17
MMP17	Q9ULZ9	350	401	333	378	Repeat	Note=Hemopexin 1
MMP17	Q9ULZ9	350	401	382	427	Repeat	Note=Hemopexin 2
MMP17	Q9ULZ9	350	401	332	523	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP10	P09238	165	207	99	476	Chain	ID=PRO_0000028765;Note=Stromelysin-2
MMP10	P09238	165	207	167	167	Metal binding	Note=Zinc 1
MMP10	P09238	165	207	169	169	Metal binding	Note=Zinc 1
MMP10	P09238	165	207	182	182	Metal binding	Note=Zinc 1
MMP10	P09238	165	207	195	195	Metal binding	Note=Zinc 1
MMP10	P09238	165	207	168	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V96
MMP10	P09238	165	207	175	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V96
MMP10	P09238	165	207	186	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V96
MMP10	P09238	165	207	189	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V96
MMP10	P09238	165	207	194	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V96
MMP10	P09238	165	207	202	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V96
SLC16A11	Q8NCK7	139	395	1	471	Chain	ID=PRO_0000286673;Note=Monocarboxylate transporter 11
SLC16A11	Q8NCK7	139	395	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	163	183	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	198	218	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	243	263	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	273	293	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	312	332	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	333	353	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	367	389	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A11	Q8NCK7	139	395	340	340	Natural variant	ID=VAR_070545;Note=Risk factor for NIDDM when associated with I-113%2C G-127 and T-443%3B loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113%2C G-127 and T-443. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24390345,ECO:0000269|PubMed:28666119;Dbxref=dbSNP:rs75418188,PMID:24390345,PMID:28666119
PMPCA	Q10713	400	421	34	525	Chain	ID=PRO_0000026767;Note=Mitochondrial-processing peptidase subunit alpha
NPC1L1	Q9UHC9	849	879	22	1359	Chain	ID=PRO_0000023266;Note=NPC1-like intracellular cholesterol transporter 1
NPC1L1	Q9UHC9	803	849	22	1359	Chain	ID=PRO_0000023266;Note=NPC1-like intracellular cholesterol transporter 1
NPC1L1	Q9UHC9	803	849	798	846	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPC1L1	Q9UHC9	849	879	847	867	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPC1L1	Q9UHC9	803	849	847	867	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPC1L1	Q9UHC9	849	879	868	1139	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPC1L1	Q9UHC9	849	879	725	1359	Alternative sequence	ID=VSP_015313;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10783261;Dbxref=PMID:10783261
NPC1L1	Q9UHC9	803	849	725	1359	Alternative sequence	ID=VSP_015313;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10783261;Dbxref=PMID:10783261
NPC1L1	Q9UHC9	849	879	850	895	Alternative sequence	ID=VSP_054503;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NPC1L1	Q9UHC9	849	879	167	1359	Natural variant	ID=VAR_080844;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	167	1359	Natural variant	ID=VAR_080844;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	406	1359	Natural variant	ID=VAR_080845;Note=Polymorphism associated with low LDL-C content and protection against coronary heart disease. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	406	1359	Natural variant	ID=VAR_080845;Note=Polymorphism associated with low LDL-C content and protection against coronary heart disease. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	483	1359	Natural variant	ID=VAR_080846;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	483	1359	Natural variant	ID=VAR_080846;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	592	1359	Natural variant	ID=VAR_080847;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	592	1359	Natural variant	ID=VAR_080847;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	601	1359	Natural variant	ID=VAR_080848;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	601	1359	Natural variant	ID=VAR_080848;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	604	1359	Natural variant	ID=VAR_080849;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	604	1359	Natural variant	ID=VAR_080849;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	738	1359	Natural variant	ID=VAR_080850;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	738	1359	Natural variant	ID=VAR_080850;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	849	879	803	1359	Natural variant	ID=VAR_080851;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
NPC1L1	Q9UHC9	803	849	803	1359	Natural variant	ID=VAR_080851;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25390462;Dbxref=PMID:25390462
MPHOSPH9	Q99550	922	969	1	1183	Chain	ID=PRO_0000096557;Note=M-phase phosphoprotein 9
MPHOSPH9	Q99550	785	818	1	1183	Chain	ID=PRO_0000096557;Note=M-phase phosphoprotein 9
MPHOSPH9	Q99550	594	645	1	1183	Chain	ID=PRO_0000096557;Note=M-phase phosphoprotein 9
MPHOSPH9	Q99550	398	440	1	1183	Chain	ID=PRO_0000096557;Note=M-phase phosphoprotein 9
MPHOSPH9	Q99550	86	116	1	1183	Chain	ID=PRO_0000096557;Note=M-phase phosphoprotein 9
MPHOSPH9	Q99550	785	818	609	804	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MPHOSPH9	Q99550	594	645	609	804	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MPHOSPH9	Q99550	922	969	947	947	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
MORC2	Q9Y6X9	233	274	2	1032	Chain	ID=PRO_0000096537;Note=MORC family CW-type zinc finger protein 2
MORC2	Q9Y6X9	233	274	236	236	Natural variant	ID=VAR_076456;Note=In CMT2Z. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26659848;Dbxref=dbSNP:rs886037934,PMID:26659848
MORC2	Q9Y6X9	233	274	248	248	Natural variant	ID=VAR_076457;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26659848;Dbxref=PMID:26659848
MORC2	Q9Y6X9	233	274	252	252	Natural variant	ID=VAR_076458;Note=In CMT2Z. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26497905,ECO:0000269|PubMed:26659848;Dbxref=dbSNP:rs864309503,PMID:26497905,PMID:26659848
MORC2	Q9Y6X9	233	274	235	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OF9
MORC2	Q9Y6X9	233	274	240	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OF9
MORC2	Q9Y6X9	233	274	247	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OF9
MORC2	Q9Y6X9	233	274	253	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OF9
MORC2	Q9Y6X9	233	274	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OF9
MORC2	Q9Y6X9	233	274	270	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OF9
MOK	Q9UQ07	231	288	1	419	Chain	ID=PRO_0000086341;Note=MAPK/MAK/MRK overlapping kinase
MOK	Q9UQ07	41	70	1	419	Chain	ID=PRO_0000086341;Note=MAPK/MAK/MRK overlapping kinase
MOK	Q9UQ07	231	288	4	285	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MOK	Q9UQ07	41	70	4	285	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MOK	Q9UQ07	231	288	1	346	Alternative sequence	ID=VSP_009143;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8781117;Dbxref=PMID:8781117
MOK	Q9UQ07	41	70	1	346	Alternative sequence	ID=VSP_009143;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8781117;Dbxref=PMID:8781117
MOK	Q9UQ07	231	288	1	234	Alternative sequence	ID=VSP_009142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8781117;Dbxref=PMID:8781117
MOK	Q9UQ07	41	70	1	234	Alternative sequence	ID=VSP_009142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8781117;Dbxref=PMID:8781117
MOK	Q9UQ07	41	70	42	71	Alternative sequence	ID=VSP_054734;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MOK	Q9UQ07	231	288	232	419	Alternative sequence	ID=VSP_009144;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MOK	Q9UQ07	231	288	248	248	Natural variant	ID=VAR_042014;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34299975,PMID:17344846
MOK	Q9UQ07	231	288	272	272	Natural variant	ID=VAR_042015;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MOK	Q9UQ07	231	288	269	269	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MORN1	Q5T089	82	119	1	497	Chain	ID=PRO_0000247454;Note=MORN repeat-containing protein 1
MORN1	Q5T089	82	119	62	84	Repeat	Note=MORN 2
MORN1	Q5T089	82	119	86	108	Repeat	Note=MORN 3
MORN1	Q5T089	82	119	109	131	Repeat	Note=MORN 4
MAP2K1	Q02750	97	146	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1	Q02750	146	172	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1	Q02750	97	146	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K1	Q02750	146	172	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K1	Q02750	97	146	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15543157,ECO:0000269|PubMed:17880056,ECO:0000269|PubMed:18951019,ECO:0000269|PubMed:19019675,ECO:0000269|PubMed:19706763,ECO:0000269|PubMed:21310613;Dbxref=PMID:15543157,PMID:17880056,PMID:18951019,PMID:19019675,PMID:19706763,PMID:21310613
MAP2K1	Q02750	146	172	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15543157,ECO:0000269|PubMed:17880056,ECO:0000269|PubMed:18951019,ECO:0000269|PubMed:19019675,ECO:0000269|PubMed:19706763,ECO:0000269|PubMed:21310613;Dbxref=PMID:15543157,PMID:17880056,PMID:18951019,PMID:19019675,PMID:19706763,PMID:21310613
MAP2K1	Q02750	146	172	150	153	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15543157,ECO:0000269|PubMed:17880056,ECO:0000269|PubMed:18951019,ECO:0000269|PubMed:19019675,ECO:0000269|PubMed:19706763,ECO:0000269|PubMed:21310613;Dbxref=PMID:15543157,PMID:17880056,PMID:18951019,PMID:19019675,PMID:19706763,PMID:21310613
MAP2K1	Q02750	97	146	144	146	Region	Note=Inhibitor binding
MAP2K1	Q02750	146	172	144	146	Region	Note=Inhibitor binding
MAP2K1	Q02750	97	146	97	97	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15543157,ECO:0000269|PubMed:17880056,ECO:0000269|PubMed:18951019,ECO:0000269|PubMed:19019675,ECO:0000269|PubMed:19706763,ECO:0000269|PubMed:21310613;Dbxref=PMID:15543157,PMID:17880056,PMID:18951019,PMID:19019675,PMID:19706763,PMID:21310613
MAP2K1	Q02750	97	146	97	97	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15543157,ECO:0000269|PubMed:17880056,ECO:0000269|PubMed:18951019,ECO:0000269|PubMed:19019675,ECO:0000269|PubMed:19161339,ECO:0000269|PubMed:19706763,ECO:0000269|PubMed:20621728,ECO:0000269|PubMed:21310613;Dbxref=PMID:15543157,PMID:17880056,PMID:18951019,PMID:19019675,PMID:19161339,PMID:19706763,PMID:20621728,PMID:21310613
MAP2K1	Q02750	146	172	147	172	Alternative sequence	ID=VSP_040500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1281467;Dbxref=PMID:1281467
MAP2K1	Q02750	97	146	128	128	Natural variant	ID=VAR_069780;Note=In CFC3. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18042262;Dbxref=dbSNP:rs730880508,PMID:18042262
MAP2K1	Q02750	97	146	130	130	Natural variant	ID=VAR_035094;Note=In CFC3. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16439621;Dbxref=dbSNP:rs121908595,PMID:16439621
MAP2K1	Q02750	97	146	97	97	Mutagenesis	Note=Inactivation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8131746;Dbxref=PMID:8131746
MAP2K1	Q02750	146	172	150	150	Mutagenesis	Note=No loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8131746;Dbxref=PMID:8131746
MAP2K1	Q02750	97	146	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
MAP2K1	Q02750	97	146	105	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
MAP2K1	Q02750	97	146	116	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
MAP2K1	Q02750	97	146	129	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
MAP2K1	Q02750	97	146	138	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
MAP2K1	Q02750	146	172	151	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
MAP2K1	Q02750	146	172	163	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQC
SLC16A3	O15427	74	122	2	465	Chain	ID=PRO_0000211394;Note=Monocarboxylate transporter 4
SLC16A3	O15427	74	122	2	465	Chain	ID=PRO_0000211394;Note=Monocarboxylate transporter 4
SLC16A3	O15427	74	122	2	465	Chain	ID=PRO_0000211394;Note=Monocarboxylate transporter 4
SLC16A3	O15427	74	122	2	465	Chain	ID=PRO_0000211394;Note=Monocarboxylate transporter 4
SLC16A3	O15427	74	122	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	83	84	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	83	84	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	83	84	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	83	84	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	85	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	85	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	85	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	85	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	106	109	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	106	109	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	106	109	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	106	109	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A3	O15427	74	122	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPC1	O15118	1159	1197	23	1278	Chain	ID=PRO_0000023261;Note=NPC intracellular cholesterol transporter 1
NPC1	O15118	838	868	23	1278	Chain	ID=PRO_0000023261;Note=NPC intracellular cholesterol transporter 1
NPC1	O15118	154	210	23	1278	Chain	ID=PRO_0000023261;Note=NPC intracellular cholesterol transporter 1
NPC1	O15118	154	210	23	261	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27238017;Dbxref=PMID:27238017
NPC1	O15118	838	868	833	853	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28784760;Dbxref=PMID:28784760
NPC1	O15118	838	868	854	1097	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28784760;Dbxref=PMID:28784760
NPC1	O15118	1159	1197	1151	1171	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28784760;Dbxref=PMID:28784760
NPC1	O15118	1159	1197	1172	1194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28784760;Dbxref=PMID:28784760
NPC1	O15118	1159	1197	1195	1215	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28784760;Dbxref=PMID:28784760
NPC1	O15118	154	210	175	205	Region	Note=Important for cholesterol binding and cholesterol transfer from NPC1 to liposomes
NPC1	O15118	154	210	158	158	Glycosylation	Note=N-linked (GlcNAc...) asparagine%3B atypical;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3GKI,ECO:0000244|PDB:3GKJ,ECO:0000244|PDB:3JD8,ECO:0000269|PubMed:19563754,ECO:0000269|PubMed:27238017;Dbxref=PMID:19563754,PMID:27238017
NPC1	O15118	154	210	185	185	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000305;evidence=ECO:0000244|PDB:3JD8,ECO:0000269|PubMed:27238017,ECO:0000305|PubMed:10821832;Dbxref=PMID:27238017,PMID:10821832
NPC1	O15118	154	210	97	238	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3GKH,ECO:0000244|PDB:3GKI,ECO:0000244|PDB:3GKJ,ECO:0000244|PDB:3JD8,ECO:0000244|PDB:5JNX,ECO:0000269|PubMed:19563754,ECO:0000269|PubMed:27238017;Dbxref=PMID:19563754,PMID:27238017
NPC1	O15118	154	210	100	160	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3GKH,ECO:0000244|PDB:3GKI,ECO:0000244|PDB:3GKJ,ECO:0000244|PDB:3JD8,ECO:0000244|PDB:5JNX,ECO:0000269|PubMed:19563754,ECO:0000269|PubMed:27238017;Dbxref=PMID:19563754,PMID:27238017
NPC1	O15118	154	210	177	184	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3GKH,ECO:0000244|PDB:3GKI,ECO:0000244|PDB:3GKJ,ECO:0000244|PDB:3JD8,ECO:0000244|PDB:5JNX,ECO:0000269|PubMed:19563754,ECO:0000269|PubMed:27238017;Dbxref=PMID:19563754,PMID:27238017
NPC1	O15118	154	210	1	267	Alternative sequence	ID=VSP_056431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NPC1	O15118	154	210	166	166	Natural variant	ID=VAR_043178;Note=In NPC1. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12955717,ECO:0000269|PubMed:16126423;Dbxref=dbSNP:rs866966704,PMID:12955717,PMID:16126423
NPC1	O15118	154	210	177	177	Natural variant	ID=VAR_008815;Note=In NPC1%3B late infantile form. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11182931;Dbxref=PMID:11182931
NPC1	O15118	154	210	177	177	Natural variant	ID=VAR_015561;Note=In NPC1. C->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11479732,ECO:0000269|PubMed:16098014,ECO:0000269|PubMed:16126423;Dbxref=dbSNP:rs80358252,PMID:11479732,PMID:16098014,PMID:16126423
NPC1	O15118	838	868	849	849	Natural variant	ID=VAR_043240;Note=In NPC1. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11754101;Dbxref=dbSNP:rs1057519242,PMID:11754101
NPC1	O15118	838	868	858	858	Natural variant	ID=VAR_008825;Note=Common polymorphism in Japanese. I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10480349,ECO:0000269|PubMed:11479732,ECO:0000269|PubMed:11754101,ECO:0000269|PubMed:12401890,ECO:0000269|PubMed:15774455,ECO:0000269|PubMed:16098014;Dbxref=dbSNP:rs1805082,PMID:10480349,PMID:11479732,PMID:11754101,PMID:12401890,PMID:15774455,PMID:16098014
NPC1	O15118	838	868	862	862	Natural variant	ID=VAR_043241;Note=In NPC1. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16126423;Dbxref=PMID:16126423
NPC1	O15118	838	868	865	865	Natural variant	ID=VAR_043242;Note=In NPC1. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16098014,ECO:0000269|PubMed:16126423;Dbxref=dbSNP:rs1160114136,PMID:16098014,PMID:16126423
NPC1	O15118	1159	1197	1165	1165	Natural variant	ID=VAR_043291;Note=In NPC1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349231;Dbxref=dbSNP:rs748862167,PMID:11349231
NPC1	O15118	1159	1197	1167	1167	Natural variant	ID=VAR_008839;Note=In NPC1. F->L
NPC1	O15118	1159	1197	1168	1168	Natural variant	ID=VAR_043292;Note=In NPC1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11333381;Dbxref=PMID:11333381
NPC1	O15118	1159	1197	1174	1174	Natural variant	ID=VAR_043293;Note=In NPC1. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16126423;Dbxref=dbSNP:rs780175800,PMID:16126423
NPC1	O15118	1159	1197	1186	1186	Natural variant	ID=VAR_008840;Note=In NPC1. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11333381,ECO:0000269|PubMed:11349231,ECO:0000269|PubMed:16126423;Dbxref=dbSNP:rs200444084,PMID:11333381,PMID:11349231,PMID:16126423
NPC1	O15118	1159	1197	1189	1189	Natural variant	ID=VAR_043294;Note=In NPC1. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349231;Dbxref=dbSNP:rs369098773,PMID:11349231
NPC1	O15118	154	210	25	257	Mutagenesis	Note=Decreases affinity for NPC2. Abolishes cholesterol transfer from NPC2 to NPC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27238017;Dbxref=PMID:27238017
NPC1	O15118	154	210	175	176	Mutagenesis	Note=No effect on cholesterol or 25-hydroxycholesterol binding. Decreases affinity for NPC2. Strongly reduces cholesterol transfer to liposomes in a NPC2-dependent manner. LL->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19563754,ECO:0000269|PubMed:27238017;Dbxref=PMID:19563754,PMID:27238017
NPC1	O15118	154	210	180	182	Mutagenesis	Note=Strongly reduces cholesterol transfer to liposomes in a NPC2-dependent manner. DAD->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	185	185	Mutagenesis	Note=Reduces glycosylation%3B when associated with Q-70 and Q-122. No effect on cholesterol and 25-hydroxycholesterol binding. Strongly reduces cholesterol transfer to liposomes in a NPC2-dependent manner. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	187	188	Mutagenesis	Note=Strongly reduces 25-hydroxycholesterol binding and cholesterol transfer to liposomes in a NPC2-dependent manner. TN->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	191	192	Mutagenesis	Note=No effect on cholesterol or 25-hydroxycholesterol binding. Nearly abolishes cholesterol transfer to liposomes in a NPC2-dependent manner. EY->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	195	196	Mutagenesis	Note=Strongly reduces 25-hydroxycholesterol binding. No effect on cholesterol binding. NK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	197	198	Mutagenesis	Note=Strongly reduces cholesterol and 25-hydroxycholesterol binding. DN->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	199	200	Mutagenesis	Note=Strongly reduces 25-hydroxycholesterol binding and cholesterol transfer to liposomes in a NPC2-dependent manner. GQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	202	203	Mutagenesis	Note=Abolishes cholesterol and 25-hydroxycholesterol binding. Abolishes cholesterol transfer from NPC2 to NPC1. PF->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19563754,ECO:0000269|PubMed:27238017;Dbxref=PMID:19563754,PMID:27238017
NPC1	O15118	154	210	204	205	Mutagenesis	Note=Strongly reduces cholesterol and 25-hydroxycholesterol binding. TI->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19563754;Dbxref=PMID:19563754
NPC1	O15118	154	210	150	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	168	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	173	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	181	183	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	186	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	154	210	199	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GKJ
NPC1	O15118	838	868	835	851	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U74
NPC1	O15118	838	868	852	855	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U74
NPC1	O15118	838	868	862	865	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U74
NPC1	O15118	838	868	868	870	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U73
NPC1	O15118	1159	1197	1151	1176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U74
NPC1	O15118	1159	1197	1183	1198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U74
MPHOSPH10	O00566	482	519	1	681	Chain	ID=PRO_0000121535;Note=U3 small nucleolar ribonucleoprotein protein MPP10
MPHOSPH10	O00566	519	555	1	681	Chain	ID=PRO_0000121535;Note=U3 small nucleolar ribonucleoprotein protein MPP10
MPHOSPH10	O00566	482	519	469	490	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MPHOSPH10	O00566	519	555	555	555	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MPP3	Q13368	486	527	1	585	Chain	ID=PRO_0000094575;Note=MAGUK p55 subfamily member 3
MPP3	Q13368	336	391	1	585	Chain	ID=PRO_0000094575;Note=MAGUK p55 subfamily member 3
MPP3	Q13368	486	527	385	570	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP3	Q13368	336	391	385	570	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP4	Q96JB8	376	433	1	637	Chain	ID=PRO_0000094577;Note=MAGUK p55 subfamily member 4
MPP4	Q96JB8	120	164	1	637	Chain	ID=PRO_0000094577;Note=MAGUK p55 subfamily member 4
MPP4	Q96JB8	93	120	1	637	Chain	ID=PRO_0000094577;Note=MAGUK p55 subfamily member 4
MPP4	Q96JB8	120	164	87	137	Domain	Note=L27 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
MPP4	Q96JB8	93	120	87	137	Domain	Note=L27 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
MPP4	Q96JB8	120	164	154	235	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
MPP4	Q96JB8	376	433	427	616	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP4	Q96JB8	120	164	93	164	Alternative sequence	ID=VSP_013991;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MPP4	Q96JB8	93	120	93	164	Alternative sequence	ID=VSP_013991;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MPP4	Q96JB8	120	164	121	164	Alternative sequence	ID=VSP_003157;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11586298,ECO:0000303|PubMed:14702039;Dbxref=PMID:11586298,PMID:14702039
MPP4	Q96JB8	376	433	311	637	Alternative sequence	ID=VSP_003158;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11586298;Dbxref=PMID:11586298
MRC2	Q9UBG0	173	231	31	1479	Chain	ID=PRO_0000046078;Note=C-type mannose receptor 2
MRC2	Q9UBG0	173	231	31	1414	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRC2	Q9UBG0	173	231	182	230	Domain	Note=Fibronectin type-II;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
MRC2	Q9UBG0	173	231	187	213	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MRC2	Q9UBG0	173	231	201	228	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MRC2	Q9UBG0	173	231	180	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EW6
MRC2	Q9UBG0	173	231	189	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EW6
MRC2	Q9UBG0	173	231	196	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EW6
MRC2	Q9UBG0	173	231	212	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EW6
MRC2	Q9UBG0	173	231	219	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EW6
MRC2	Q9UBG0	173	231	225	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EW6
CDC42BPG	Q6DT37	225	292	1	1551	Chain	ID=PRO_0000086397;Note=Serine/threonine-protein kinase MRCK gamma
CDC42BPG	Q6DT37	84	112	1	1551	Chain	ID=PRO_0000086397;Note=Serine/threonine-protein kinase MRCK gamma
CDC42BPG	Q6DT37	225	292	71	337	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15194684;Dbxref=PMID:15194684
CDC42BPG	Q6DT37	84	112	71	337	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15194684;Dbxref=PMID:15194684
CDC42BPG	Q6DT37	84	112	77	85	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P54265,ECO:0000255|PROSITE-ProRule:PRU00159
CDC42BPG	Q6DT37	84	112	100	100	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:15194684;Dbxref=PMID:15194684
CDC42BPG	Q6DT37	225	292	228	228	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
CDC42BPG	Q6DT37	225	292	234	234	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
CDC42BPG	Q6DT37	225	292	280	280	Natural variant	ID=VAR_040841;Note=In a glioblastoma multiforme sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs770462360,PMID:17344846
MTHFD2L	Q9H903	210	252	1	347	Chain	ID=PRO_0000337097;Note=Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
MTHFD2L	Q9H903	210	252	214	216	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P13995
MTHFD2L	Q9H903	210	252	247	247	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P13995
MTHFD2L	Q9H903	210	252	1	277	Alternative sequence	ID=VSP_041877;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MED1	Q15648	216	246	1	1581	Chain	ID=PRO_0000058552;Note=Mediator of RNA polymerase II transcription subunit 1
MED1	Q15648	167	191	1	1581	Chain	ID=PRO_0000058552;Note=Mediator of RNA polymerase II transcription subunit 1
MED1	Q15648	143	166	1	1581	Chain	ID=PRO_0000058552;Note=Mediator of RNA polymerase II transcription subunit 1
MED1	Q15648	216	246	1	670	Region	Note=Interaction with the Mediator complex and THRA
MED1	Q15648	167	191	1	670	Region	Note=Interaction with the Mediator complex and THRA
MED1	Q15648	143	166	1	670	Region	Note=Interaction with the Mediator complex and THRA
MED1	Q15648	216	246	16	590	Region	Note=Interaction with ESR1
MED1	Q15648	167	191	16	590	Region	Note=Interaction with ESR1
MED1	Q15648	143	166	16	590	Region	Note=Interaction with ESR1
MED1	Q15648	167	191	108	212	Region	Note=Interaction with the Mediator complex
MED1	Q15648	143	166	108	212	Region	Note=Interaction with the Mediator complex
MED1	Q15648	216	246	215	390	Region	Note=Interaction with the Mediator complex
MED1	Q15648	143	166	147	147	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MED13	Q9UHV7	2039	2097	1	2174	Chain	ID=PRO_0000065584;Note=Mediator of RNA polymerase II transcription subunit 13
MED13	Q9UHV7	1874	1927	1	2174	Chain	ID=PRO_0000065584;Note=Mediator of RNA polymerase II transcription subunit 13
MED13	Q9UHV7	1688	1752	1	2174	Chain	ID=PRO_0000065584;Note=Mediator of RNA polymerase II transcription subunit 13
MED13	Q9UHV7	1268	1322	1	2174	Chain	ID=PRO_0000065584;Note=Mediator of RNA polymerase II transcription subunit 13
MED13	Q9UHV7	428	655	1	2174	Chain	ID=PRO_0000065584;Note=Mediator of RNA polymerase II transcription subunit 13
MED13	Q9UHV7	391	427	1	2174	Chain	ID=PRO_0000065584;Note=Mediator of RNA polymerase II transcription subunit 13
MED13	Q9UHV7	1268	1322	1279	1283	Motif	Note=LXXLL motif 2
MED13	Q9UHV7	391	427	395	395	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MED13	Q9UHV7	428	655	500	500	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
MED13	Q9UHV7	428	655	504	504	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MED13	Q9UHV7	428	655	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SWW4
MED13	Q9UHV7	428	655	537	537	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MED13	Q9UHV7	391	427	392	392	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
MED13	Q9UHV7	428	655	467	467	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLPH	Q9BV36	185	225	1	600	Chain	ID=PRO_0000190222;Note=Melanophilin
MLPH	Q9BV36	340	368	1	600	Chain	ID=PRO_0000190222;Note=Melanophilin
MLPH	Q9BV36	430	482	1	600	Chain	ID=PRO_0000190222;Note=Melanophilin
MLPH	Q9BV36	482	513	1	600	Chain	ID=PRO_0000190222;Note=Melanophilin
MLPH	Q9BV36	430	482	373	496	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MLPH	Q9BV36	482	513	373	496	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MLPH	Q9BV36	185	225	186	225	Alternative sequence	ID=VSP_042158;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLPH	Q9BV36	340	368	226	368	Alternative sequence	ID=VSP_055730;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLPH	Q9BV36	340	368	341	368	Alternative sequence	ID=VSP_007554;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MLPH	Q9BV36	430	482	430	481	Alternative sequence	ID=VSP_042159;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLPH	Q9BV36	340	368	347	347	Natural variant	ID=VAR_015694;Note=H->R;Dbxref=dbSNP:rs2292884
MLPH	Q9BV36	430	482	451	451	Natural variant	ID=VAR_061754;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs58256353,PMID:14702039
NCOA2	Q15596	1431	1461	2	1464	Chain	ID=PRO_0000094402;Note=Nuclear receptor coactivator 2
NCOA2	Q15596	868	937	2	1464	Chain	ID=PRO_0000094402;Note=Nuclear receptor coactivator 2
NCOA2	Q15596	868	937	730	1121	Region	Note=Interaction with ARNTL;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026
NCOA2	Q15596	868	937	878	882	Motif	Note=LXXLL motif 4
NCOA2	Q15596	868	937	869	870	Site	Note=Breakpoint for translocation to form KAT6A-NCOA2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676584,ECO:0000269|PubMed:15657427,ECO:0000269|PubMed:9558366;Dbxref=PMID:12676584,PMID:15657427,PMID:9558366
NCOA2	Q15596	868	937	874	874	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026
NCOA2	Q15596	1431	1461	1454	1454	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MLEC	Q14165	138	197	29	292	Chain	ID=PRO_0000013982;Note=Malectin
MLEC	Q14165	138	197	29	269	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPATA18	Q8TC71	141	172	1	538	Chain	ID=PRO_0000254165;Note=Mitochondria-eating protein
SPATA18	Q8TC71	340	393	1	538	Chain	ID=PRO_0000254165;Note=Mitochondria-eating protein
SPATA18	Q8TC71	493	521	1	538	Chain	ID=PRO_0000254165;Note=Mitochondria-eating protein
SPATA18	Q8TC71	141	172	118	187	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPATA18	Q8TC71	141	172	156	156	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6AYL6
SPATA18	Q8TC71	141	172	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6AYL6
SPATA18	Q8TC71	493	521	509	509	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6AYL6
SPATA18	Q8TC71	141	172	141	173	Alternative sequence	ID=VSP_041048;Note=In isoform 2. DLVETEKNLEESKNRSAISLLAAEEEINQLKKQ->E;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:21264221;Dbxref=PMID:14702039,PMID:21264221
MYL12A	P19105	60	114	1	171	Chain	ID=PRO_0000198733;Note=Myosin regulatory light chain 12A
MYL12A	P19105	60	114	1	171	Chain	ID=PRO_0000198733;Note=Myosin regulatory light chain 12A
MYL12A	P19105	60	114	1	171	Chain	ID=PRO_0000198733;Note=Myosin regulatory light chain 12A
MYL12A	P19105	60	114	1	171	Chain	ID=PRO_0000198733;Note=Myosin regulatory light chain 12A
MYL12A	P19105	60	114	28	63	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	28	63	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	28	63	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	28	63	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	97	132	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	97	132	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	97	132	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL12A	P19105	60	114	97	132	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MLH3	Q9UHC1	1214	1238	1	1453	Chain	ID=PRO_0000178003;Note=DNA mismatch repair protein Mlh3
MLH3	Q9UHC1	1155	1190	1	1453	Chain	ID=PRO_0000178003;Note=DNA mismatch repair protein Mlh3
MLH3	Q9UHC1	1093	1126	1	1453	Chain	ID=PRO_0000178003;Note=DNA mismatch repair protein Mlh3
MLH3	Q9UHC1	1214	1238	1	1453	Chain	ID=PRO_0000178003;Note=DNA mismatch repair protein Mlh3
MLH3	Q9UHC1	1155	1190	1	1453	Chain	ID=PRO_0000178003;Note=DNA mismatch repair protein Mlh3
MLH3	Q9UHC1	1093	1126	1	1453	Chain	ID=PRO_0000178003;Note=DNA mismatch repair protein Mlh3
MLH3	Q9UHC1	1214	1238	1215	1238	Alternative sequence	ID=VSP_003290;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLH3	Q9UHC1	1214	1238	1215	1238	Alternative sequence	ID=VSP_003290;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLH3	Q9UHC1	1093	1126	1105	1105	Natural variant	ID=VAR_023354;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28757008
MLH3	Q9UHC1	1093	1126	1105	1105	Natural variant	ID=VAR_023354;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28757008
MLH3	Q9UHC1	1155	1190	1163	1163	Natural variant	ID=VAR_023355;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28757011
MLH3	Q9UHC1	1155	1190	1163	1163	Natural variant	ID=VAR_023355;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28757011
MMP26	Q9NRE1	156	198	90	261	Chain	ID=PRO_0000028856;Note=Matrix metalloproteinase-26
MMP26	Q9NRE1	156	198	90	261	Chain	ID=PRO_0000028856;Note=Matrix metalloproteinase-26
RASAL2	Q9UJF2	943	988	1	1139	Chain	ID=PRO_0000056653;Note=Ras GTPase-activating protein nGAP
MMP15	P51511	104	146	42	131	Propeptide	ID=PRO_0000028808;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP15	P51511	104	146	132	669	Chain	ID=PRO_0000028809;Note=Matrix metalloproteinase-15
MMP15	P51511	104	146	132	625	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMP15	P51511	104	146	109	116	Motif	Note=Cysteine switch;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP15	P51511	104	146	111	111	Metal binding	Note=Zinc%3B in inhibited form;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP7	P09237	204	258	95	267	Chain	ID=PRO_0000028739;Note=Matrilysin
MMP7	P09237	161	204	95	267	Chain	ID=PRO_0000028739;Note=Matrilysin
MMP7	P09237	204	258	215	215	Active site	.
MMP7	P09237	161	204	163	163	Metal binding	Note=Zinc 1
MMP7	P09237	161	204	165	165	Metal binding	Note=Zinc 1
MMP7	P09237	161	204	170	170	Metal binding	Note=Calcium 2
MMP7	P09237	161	204	171	171	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
MMP7	P09237	161	204	173	173	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
MMP7	P09237	161	204	175	175	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
MMP7	P09237	161	204	178	178	Metal binding	Note=Zinc 1
MMP7	P09237	161	204	185	185	Metal binding	Note=Calcium 1%3B via carbonyl oxygen
MMP7	P09237	161	204	187	187	Metal binding	Note=Calcium 1%3B via carbonyl oxygen
MMP7	P09237	161	204	189	189	Metal binding	Note=Calcium 1
MMP7	P09237	161	204	191	191	Metal binding	Note=Zinc 1
MMP7	P09237	161	204	193	193	Metal binding	Note=Calcium 2
MMP7	P09237	161	204	196	196	Metal binding	Note=Calcium 2
MMP7	P09237	204	258	214	214	Metal binding	Note=Zinc 2%3B catalytic
MMP7	P09237	204	258	218	218	Metal binding	Note=Zinc 2%3B catalytic
MMP7	P09237	204	258	224	224	Metal binding	Note=Zinc 2%3B catalytic
MMP7	P09237	204	258	241	241	Natural variant	ID=VAR_021028;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17886506
MMP7	P09237	161	204	161	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UE2
MMP7	P09237	161	204	164	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	161	204	171	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	161	204	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	161	204	182	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	161	204	185	188	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	161	204	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	204	258	198	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	161	204	198	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	204	258	208	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MMP7	P09237	204	258	233	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MMQ
MMP7	P09237	204	258	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDY
MMP7	P09237	204	258	248	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6D
MAT2A	P31153	56	97	1	395	Chain	ID=PRO_0000174435;Note=S-adenosylmethionine synthase isoform type-2
MAT2A	P31153	135	183	1	395	Chain	ID=PRO_0000174435;Note=S-adenosylmethionine synthase isoform type-2
MAT2A	P31153	135	183	179	181	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4KTT,ECO:0000244|PDB:4NDN,ECO:0000244|PDB:5A19,ECO:0000244|PDB:5A1G,ECO:0000244|PDB:5A1I,ECO:0000305|PubMed:25075345,ECO:0000305|PubMed:26858410;Dbxref=PMID:25075345,PMID:26858410
MAT2A	P31153	56	97	57	57	Metal binding	Note=Potassium;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A817
MAT2A	P31153	56	97	70	70	Binding site	Note=Methionine;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:4NDN,ECO:0000305|PubMed:25075345;Dbxref=PMID:25075345
MAT2A	P31153	56	97	81	81	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MAT2A	P31153	56	97	1	63	Alternative sequence	ID=VSP_056186;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAT2A	P31153	56	97	53	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
MAT2A	P31153	56	97	64	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
MAT2A	P31153	56	97	79	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
MAT2A	P31153	56	97	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
MAT2A	P31153	135	183	136	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
MAT2A	P31153	135	183	152	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
MAT2A	P31153	135	183	171	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NDN
MAT2A	P31153	135	183	176	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1I
NFYA	P23511	25	54	1	347	Chain	ID=PRO_0000198768;Note=Nuclear transcription factor Y subunit alpha
NFYA	P23511	103	147	1	347	Chain	ID=PRO_0000198768;Note=Nuclear transcription factor Y subunit alpha
NFYA	P23511	238	296	1	347	Chain	ID=PRO_0000198768;Note=Nuclear transcription factor Y subunit alpha
NFYA	P23511	238	296	296	321	DNA binding	Note=NFYA/HAP2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00966
NFYA	P23511	238	296	266	289	Motif	Note=Subunit association domain (SAD)
NFYA	P23511	25	54	14	161	Compositional bias	Note=Gln-rich
NFYA	P23511	103	147	14	161	Compositional bias	Note=Gln-rich
NFYA	P23511	25	54	26	54	Alternative sequence	ID=VSP_000849;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NFYA	P23511	238	296	273	273	Sequence conflict	Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFYA	P23511	238	296	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AWL
NFYA	P23511	238	296	269	271	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AWL
NFYA	P23511	238	296	272	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AWL
MAPK1	P28482	241	285	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
MAPK1	P28482	164	203	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
MAPK1	P28482	241	285	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
MAPK1	P28482	164	203	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
MAPK1	P28482	241	285	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK1	P28482	164	203	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK1	P28482	241	285	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK1	P28482	164	203	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK1	P28482	241	285	259	277	DNA binding	.
MAPK1	P28482	241	285	259	277	DNA binding	.
MAPK1	P28482	164	203	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
MAPK1	P28482	164	203	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
MAPK1	P28482	164	203	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0000269|PubMed:9827991;Dbxref=PMID:16139248,PMID:16242327,PMID:17194451,PMID:17300186,PMID:19827834,PMID:9827991
MAPK1	P28482	164	203	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0000269|PubMed:9827991;Dbxref=PMID:16139248,PMID:16242327,PMID:17194451,PMID:17300186,PMID:19827834,PMID:9827991
MAPK1	P28482	164	203	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0000269|PubMed:9827991;Dbxref=PMID:16139248,PMID:16242327,PMID:17194451,PMID:17300186,PMID:19827834,PMID:9827991
MAPK1	P28482	164	203	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0000269|PubMed:9827991;Dbxref=PMID:16139248,PMID:16242327,PMID:17194451,PMID:17300186,PMID:19827834,PMID:9827991
MAPK1	P28482	164	203	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
MAPK1	P28482	164	203	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
MAPK1	P28482	164	203	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:19053285,ECO:0000269|PubMed:19494114;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163,PMID:19053285,PMID:19494114
MAPK1	P28482	164	203	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:19053285,ECO:0000269|PubMed:19494114;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163,PMID:19053285,PMID:19494114
MAPK1	P28482	164	203	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
MAPK1	P28482	164	203	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
MAPK1	P28482	241	285	246	246	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
MAPK1	P28482	241	285	246	246	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
MAPK1	P28482	241	285	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
MAPK1	P28482	241	285	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
MAPK1	P28482	241	285	284	284	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
MAPK1	P28482	241	285	284	284	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
MAPK1	P28482	241	285	242	285	Alternative sequence	ID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MAPK1	P28482	241	285	242	285	Alternative sequence	ID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MAPK1	P28482	164	203	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
MAPK1	P28482	164	203	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
MAPK1	P28482	164	203	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
MAPK1	P28482	164	203	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
MAPK1	P28482	164	203	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
MAPK1	P28482	164	203	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
MAPK1	P28482	164	203	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I5Z
MAPK1	P28482	164	203	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I5Z
MAPK1	P28482	164	203	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y9Q
MAPK1	P28482	164	203	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y9Q
MAPK1	P28482	164	203	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	164	203	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K4I
MAPK1	P28482	164	203	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K4I
MAPK1	P28482	241	285	235	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	235	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	258	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	258	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	275	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	275	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NHO
MAPK1	P28482	241	285	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NHO
MAPK1	P28482	241	285	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MAPK1	P28482	241	285	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
MLH1	P40692	69	102	2	756	Chain	ID=PRO_0000178000;Note=DNA mismatch repair protein Mlh1
MLH1	P40692	577	632	2	756	Chain	ID=PRO_0000178000;Note=DNA mismatch repair protein Mlh1
MLH1	P40692	632	663	2	756	Chain	ID=PRO_0000178000;Note=DNA mismatch repair protein Mlh1
MLH1	P40692	69	102	82	84	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:4P7A,ECO:0000305|PubMed:26249686;Dbxref=PMID:26249686
MLH1	P40692	69	102	100	104	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:4P7A,ECO:0000305|PubMed:26249686;Dbxref=PMID:26249686
MLH1	P40692	577	632	410	650	Region	Note=Interaction with EXO1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11427529,ECO:0000269|PubMed:11429708,ECO:0000269|PubMed:12414623,ECO:0000269|PubMed:14676842,ECO:0000269|PubMed:22753075;Dbxref=PMID:11427529,PMID:11429708,PMID:12414623,PMID:14676842,PMID:22753075
MLH1	P40692	632	663	410	650	Region	Note=Interaction with EXO1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11427529,ECO:0000269|PubMed:11429708,ECO:0000269|PubMed:12414623,ECO:0000269|PubMed:14676842,ECO:0000269|PubMed:22753075;Dbxref=PMID:11427529,PMID:11429708,PMID:12414623,PMID:14676842,PMID:22753075
MLH1	P40692	69	102	1	241	Alternative sequence	ID=VSP_045201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLH1	P40692	69	102	1	101	Alternative sequence	ID=VSP_047023;Note=In isoform 3. MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRG->MAF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLH1	P40692	69	102	69	69	Natural variant	ID=VAR_004441;Note=In HNPCC2%3B decreased mismatch repair activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10627141;Dbxref=dbSNP:rs63751661,PMID:10627141
MLH1	P40692	69	102	71	71	Natural variant	ID=VAR_043393;Note=In HNPCC2%3B decreased mismatch repair activity%3B loss of protein expression. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944;Dbxref=PMID:16083711,PMID:21120944
MLH1	P40692	69	102	77	77	Natural variant	ID=VAR_004442;Note=In HNPCC2%3B decreased mismatch repair activity%3B loss of nuclear localization%3B normal interaction with PMS2. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10660333,ECO:0000269|PubMed:11793442,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:18561205,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63749859,PMID:10660333,PMID:11793442,PMID:16083711,PMID:18561205,PMID:21120944
MLH1	P40692	69	102	77	77	Natural variant	ID=VAR_012904;Note=In CRC%3B sporadic%3B early onset. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9032648;Dbxref=dbSNP:rs63750437,PMID:9032648
MLH1	P40692	69	102	80	80	Natural variant	ID=VAR_012905;Note=In HNPCC2%3B decreased mismatch repair activity. F->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11726306,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63749990,PMID:11726306,PMID:16083711,PMID:21120944
MLH1	P40692	69	102	84	84	Natural variant	ID=VAR_012906;Note=In HNPCC2%3B decreased mismatch repair activity. K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10323887,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63750641,PMID:10323887,PMID:16083711,PMID:21120944
MLH1	P40692	69	102	93	93	Natural variant	ID=VAR_004443;Note=Common polymorphism%3B normal interaction with PMS2%3B no decrease in mismatch repair activity%3B no effect on nuclear localization. S->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10671064,ECO:0000269|PubMed:11793442,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:18033691,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs41295282,PMID:10671064,PMID:11793442,PMID:16083711,PMID:18033691,PMID:20020535,PMID:21120944,PMID:22753075
MLH1	P40692	69	102	98	98	Natural variant	ID=VAR_054523;Note=Associated with HNPCC2%3B no effect on MLH1 splicing. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607725,PMID:18561205
MLH1	P40692	69	102	101	101	Natural variant	ID=VAR_022664;Note=In HNPCC2%3B no effect on MLH1 splicing. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14635101,ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607727,PMID:14635101,PMID:18561205
MLH1	P40692	69	102	101	101	Natural variant	ID=VAR_054524;Note=Associated with HNPCC2%3B no effect on MLH1 splicing. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607726,PMID:18561205
MLH1	P40692	69	102	102	102	Natural variant	ID=VAR_043394;Note=In HNPCC2%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17510385;Dbxref=dbSNP:rs63750453,PMID:17510385
MLH1	P40692	577	632	578	632	Natural variant	ID=VAR_076348;Note=In HNPCC2%3B decreased mismatch repair activity%3B defective in interaction with PMS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120944;Dbxref=PMID:21120944
MLH1	P40692	632	663	578	632	Natural variant	ID=VAR_076348;Note=In HNPCC2%3B decreased mismatch repair activity%3B defective in interaction with PMS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120944;Dbxref=PMID:21120944
MLH1	P40692	577	632	578	578	Natural variant	ID=VAR_004459;Note=In HNPCC2 and CRC%3B unknown pathological significance%3B no decrease in mismatch repair activity%3B no effect on nuclear localization. E->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10598809,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs63751612,PMID:10598809,PMID:20020535,PMID:22753075
MLH1	P40692	577	632	582	582	Natural variant	ID=VAR_076349;Note=In HNPCC2%3B decreased mismatch repair activity%3B no effect on nuclear localization. L->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs63751713,PMID:20020535,PMID:22753075
MLH1	P40692	577	632	582	582	Natural variant	ID=VAR_004460;Note=In HNPCC2%3B type II. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7757073;Dbxref=dbSNP:rs63751713,PMID:7757073
MLH1	P40692	577	632	585	585	Natural variant	ID=VAR_054534;Note=Associated with HNPCC2%3B no effect on MLH1 splicing. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607865,PMID:18561205
MLH1	P40692	577	632	586	586	Natural variant	ID=VAR_015689;Note=In HNPCC2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655562;Dbxref=dbSNP:rs63751176,PMID:12655562
MLH1	P40692	577	632	588	588	Natural variant	ID=VAR_012924;Note=In HNPCC2. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10777691;Dbxref=dbSNP:rs63750575,PMID:10777691
MLH1	P40692	577	632	589	589	Natural variant	ID=VAR_043419;Note=In HNPCC2%3B decreased mismatch repair activity%3B loss of interaction with PMS2 and EXO1%3B loss of protein expression%3B may lose nuclear localization. A->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs63750016,PMID:16083711,PMID:20020535,PMID:21120944,PMID:22753075
MLH1	P40692	577	632	596	596	Natural variant	ID=VAR_043420;Note=In HNPCC2. Missing
MLH1	P40692	577	632	601	601	Natural variant	ID=VAR_043421;Note=In CRC%3B unknown pathological significance. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655564;Dbxref=dbSNP:rs63750718,PMID:12655564
MLH1	P40692	577	632	603	603	Natural variant	ID=VAR_012925;Note=In HNPCC2%3B unknown pathological significance%3B no effect on MLH1 splicing. P->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11726306,ECO:0000269|PubMed:12095971,ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs63750876,PMID:11726306,PMID:12095971,PMID:18561205
MLH1	P40692	577	632	607	607	Natural variant	ID=VAR_012926;Note=In HNPCC2%3B unknown pathological significance%3B also found in lobular carcinoma in situ of the breast%3B no effect on MLH1 splicing. L->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10713887,ECO:0000269|PubMed:11369138,ECO:0000269|PubMed:11839723,ECO:0000269|PubMed:18033691,ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs41295284,PMID:10713887,PMID:11369138,PMID:11839723,PMID:18033691,PMID:18561205
MLH1	P40692	577	632	612	612	Natural variant	ID=VAR_043422;Note=In HNPCC2%3B loss of protein expression%3B loss of nuclear localization. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944;Dbxref=PMID:16083711,PMID:21120944
MLH1	P40692	577	632	616	616	Natural variant	ID=VAR_004461;Note=In HNPCC2 and MMRCS%3B abrogates interaction with EXO1%3B loss of protein expression%3B loss of nuclear localization%3B no effect on MLH1 splicing. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10480359,ECO:0000269|PubMed:11427529,ECO:0000269|PubMed:14635101,ECO:0000269|PubMed:14961575,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:7661930,ECO:0000269|PubMed:8571956,ECO:0000269|PubMed:8872463,ECO:0000269|PubMed:8993976,ECO:0000269|PubMed:9311737;Dbxref=PMID:10480359,PMID:11427529,PMID:14635101,PMID:14961575,PMID:16083711,PMID:21120944,PMID:7661930,PMID:8571956,PMID:8872463,PMID:8993976,PMID:9311737
MLH1	P40692	577	632	618	618	Natural variant	ID=VAR_004462;Note=In HNPCC2%3B unknown pathological significance%3B requires 2 nucleotide substitutions%3B interacts weakly with PMS2%3B no decrease in mismatch repair activity%3B no effect on nuclear localization. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10598809,ECO:0000269|PubMed:10713887,ECO:0000269|PubMed:11726306,ECO:0000269|PubMed:11870161,ECO:0000269|PubMed:12200596,ECO:0000269|PubMed:12373605,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:18033691,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075,ECO:0000269|PubMed:9311737;Dbxref=dbSNP:rs35502531,PMID:10598809,PMID:10713887,PMID:11726306,PMID:11870161,PMID:12200596,PMID:12373605,PMID:16083711,PMID:18033691,PMID:20020535,PMID:21120944,PMID:22753075,PMID:9311737
MLH1	P40692	577	632	618	618	Natural variant	ID=VAR_043424;Note=In CRC. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14504054;Dbxref=dbSNP:rs63750449,PMID:14504054
MLH1	P40692	577	632	618	618	Natural variant	ID=VAR_004463;Note=In HNPCC2%3B type II%3B loss of nuclear localization. K->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10573010,ECO:0000269|PubMed:11839723,ECO:0000269|PubMed:12095971,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:7757073,ECO:0000269|PubMed:8872463;Dbxref=dbSNP:rs63750449,PMID:10573010,PMID:11839723,PMID:12095971,PMID:16083711,PMID:21120944,PMID:7757073,PMID:8872463
MLH1	P40692	577	632	618	618	Natural variant	ID=VAR_043423;Note=In HNPCC2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16451135;Dbxref=PMID:16451135
MLH1	P40692	577	632	619	619	Natural variant	ID=VAR_054535;Note=Associated with HNPCC2%3B no effect on MLH1 splicing. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607866,PMID:18561205
MLH1	P40692	577	632	622	622	Natural variant	ID=VAR_012927;Note=In HNPCC2. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11748856;Dbxref=dbSNP:rs63750693,PMID:11748856
MLH1	P40692	577	632	623	623	Natural variant	ID=VAR_043425;Note=In HNPCC2%3B unknown pathological significance. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16451135;Dbxref=PMID:16451135
MLH1	P40692	577	632	626	627	Natural variant	ID=VAR_004464;Note=In HNPCC2. FS->ST
MLH1	P40692	577	632	631	631	Natural variant	ID=VAR_043426;Note=In HNPCC2%3B unknown pathological significance. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12132870;Dbxref=dbSNP:rs63750240,PMID:12132870
MLH1	P40692	632	663	633	663	Natural variant	ID=VAR_076350;Note=In HNPCC2%3B decreased mismatch repair activity%3B defective in interaction with PMS2%3B loss of protein expression%3B loss of nuclear localization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120944;Dbxref=PMID:21120944
MLH1	P40692	632	663	635	635	Natural variant	ID=VAR_043427;Note=In gastric cancer%3B unknown pathological significance. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12132870;Dbxref=dbSNP:rs63751047,PMID:12132870
MLH1	P40692	632	663	636	636	Natural variant	ID=VAR_043428;Note=In HNPCC2. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15365995;Dbxref=dbSNP:rs63750825,PMID:15365995
MLH1	P40692	632	663	640	640	Natural variant	ID=VAR_054536;Note=Associated with HNPCC2%3B no effect on MLH1 splicing. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607875,PMID:18561205
MLH1	P40692	632	663	640	640	Natural variant	ID=VAR_043429;Note=In HNPCC2%3B no effect on MLH1 splicing. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15365995,ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs63749792,PMID:15365995,PMID:18561205
MLH1	P40692	632	663	646	646	Natural variant	ID=VAR_043430;Note=In HNPCC2%3B defective in interaction with PMS2 and EXO1%3B no decrease in mismatch repair activity. Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11870161,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs35045067,PMID:11870161,PMID:16083711,PMID:20020535,PMID:21120944,PMID:22753075
MLH1	P40692	632	663	648	648	Natural variant	ID=VAR_012928;Note=In HNPCC2%3B unknown pathological significance%3B defective in interaction with PMS2 and EXO1%3B may lose nuclear localization%3B loss of protein expression%3B no decrease in mismatch repair activity. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11726306,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs63750610,PMID:11726306,PMID:16083711,PMID:20020535,PMID:21120944,PMID:22753075
MLH1	P40692	632	663	648	648	Natural variant	ID=VAR_022669;Note=In HNPCC2%3B the protein is unstable%3B loss of nuclear localization%3B loss of protein expression%3B no decrease in mismatch repair activity. P->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11839723,ECO:0000269|PubMed:15139004,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63750899,PMID:11839723,PMID:15139004,PMID:16083711,PMID:21120944
MLH1	P40692	632	663	654	654	Natural variant	ID=VAR_043431;Note=In HNPCC2%3B decreased mismatch repair activity%3B defective in interaction with PMS2 and EXO1%3B loss of protein expression%3B may lose nuclear localization. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075;Dbxref=dbSNP:rs63750726,PMID:16083711,PMID:20020535,PMID:21120944,PMID:22753075
MLH1	P40692	632	663	655	655	Natural variant	ID=VAR_043432;Note=In HNPCC2%3B also found in an endometrial cancer sample%3B no effect on MLH1 splicing. I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12115348,ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs55907433,PMID:12115348,PMID:18561205
MLH1	P40692	632	663	656	656	Natural variant	ID=VAR_054537;Note=In HNPCC2%3B no effect on MLH1 splicing. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18561205;Dbxref=dbSNP:rs267607876,PMID:18561205
MLH1	P40692	632	663	657	657	Natural variant	ID=VAR_043433;Note=In HNPCC2%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16451135;Dbxref=PMID:16451135
MLH1	P40692	632	663	659	659	Natural variant	ID=VAR_012929;Note=In HNPCC2. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10713887,ECO:0000269|PubMed:11427529;Dbxref=dbSNP:rs63749900,PMID:10713887,PMID:11427529
MLH1	P40692	632	663	659	659	Natural variant	ID=VAR_004465;Note=In HNPCC2%3B interacts only very weakly with PMS2%3B abrogates interaction with EXO1%3B decreased mismatch repair activity%3B may lose nuclear localization. R->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11793442,ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:20020535,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22753075,ECO:0000269|PubMed:9311737;Dbxref=dbSNP:rs63749900,PMID:11793442,PMID:16083711,PMID:20020535,PMID:21120944,PMID:22753075,PMID:9311737
MLH1	P40692	632	663	659	659	Natural variant	ID=VAR_043434;Note=In HNPCC2%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16083711,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63749900,PMID:16083711,PMID:21120944
MLH1	P40692	632	663	662	662	Natural variant	ID=VAR_012930;Note=In HNPCC2%3B unknown pathological significance. T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11726306,ECO:0000269|PubMed:11754112;Dbxref=dbSNP:rs587778964,PMID:11726306,PMID:11754112
MLH1	P40692	69	102	70	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P7A
MLH1	P40692	69	102	73	77	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P7A
MLH1	P40692	577	632	572	581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLH1	P40692	577	632	582	590	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLH1	P40692	577	632	593	595	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLH1	P40692	577	632	604	626	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLH1	P40692	632	663	634	641	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLH1	P40692	632	663	650	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLH1	P40692	632	663	653	662	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBN
MLIP	Q5VWP3	21	73	1	458	Chain	ID=PRO_0000089538;Note=Muscular LMNA-interacting protein
MLIP	Q5VWP3	204	228	1	458	Chain	ID=PRO_0000089538;Note=Muscular LMNA-interacting protein
MLIP	Q5VWP3	250	278	1	458	Chain	ID=PRO_0000089538;Note=Muscular LMNA-interacting protein
MLIP	Q5VWP3	371	439	1	458	Chain	ID=PRO_0000089538;Note=Muscular LMNA-interacting protein
MLIP	Q5VWP3	21	73	1	40	Region	Note=Interaction with LMNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21498514;Dbxref=PMID:21498514
MLIP	Q5VWP3	204	228	150	302	Region	Note=Required for interaction with ISL1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5FW52
MLIP	Q5VWP3	250	278	150	302	Region	Note=Required for interaction with ISL1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5FW52
MLIP	Q5VWP3	21	73	1	73	Alternative sequence	ID=VSP_015320;Note=In isoform 2. MELEKREKRSLLNKNLEEKLTVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNR->MCSWYLGFECS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLIP	Q5VWP3	21	73	1	21	Alternative sequence	ID=VSP_041463;Note=In isoform 3. MELEKREKRSLLNKNLEEKLT->MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLIP	Q5VWP3	204	228	204	204	Alternative sequence	ID=VSP_041464;Note=In isoform 3 and isoform 4. Q->QLTSSPTTSEQLACKPPAFSFVSPTNPNTPPDPVNLEGASVLEEFHTRRLDVGGAVVEESATYFQTTAHSTPFSASKGTSSTLLFPHSTQLSGSNLPSSTAADPKPGLTSEVLKKTTLTSHVLSHGESPRTSSSPPSSSASLKSNSASYIPVRIVTHSLSPSPKPFTSSFHGSSSTICSQMSSSGNLSKSGVKSPVPSRLALLTAILKSNPSHQRPFSPASCPTFSLNSPASSTLTLDQKEKQTPPTPKKSLSSCSLRAGSPDQGELQVSELTQQSFHLPVFTKSTPLSQAPSLSPTKQASSSLASMNVERTPSPTLKSNTMLSLLQTSTSSSVGLPPVPPSSSLSSLKSKQDGDLRGPENPRNIHTYPSTLASSALSSLSPPINQRATFSSSEKCFHPSPALSSLINRSKRASSQLSGQELNPSALPSLPVSSADFASLPNLRSSSLPHANLPTLVPQLSPSALHPHCGSGTLPSRLGKSESTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLIP	Q5VWP3	204	228	205	298	Alternative sequence	ID=VSP_015321;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLIP	Q5VWP3	250	278	205	298	Alternative sequence	ID=VSP_015321;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLIP	Q5VWP3	371	439	372	439	Alternative sequence	ID=VSP_015322;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLIP	Q5VWP3	371	439	372	391	Alternative sequence	ID=VSP_055202;Note=In isoform 4. DVTVPPKPVSLHPLYQTKLY->AAHSVDSYCNGSDTSGPWLL;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLIP	Q5VWP3	371	439	392	458	Alternative sequence	ID=VSP_055203;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLIP	Q5VWP3	371	439	376	376	Natural variant	ID=VAR_056800;Note=P->S;Dbxref=dbSNP:rs2275769
MAPK6	Q16659	233	288	1	721	Chain	ID=PRO_0000186257;Note=Mitogen-activated protein kinase 6
MAPK6	Q16659	233	288	20	316	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK6	Q16659	233	288	237	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L
MAPK6	Q16659	233	288	253	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L
MAPK6	Q16659	233	288	265	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L
MAPK6	Q16659	233	288	278	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L
MAPK6	Q16659	233	288	287	294	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6L
MAPK12	P53778	206	230	1	367	Chain	ID=PRO_0000186282;Note=Mitogen-activated protein kinase 12
MAPK12	P53778	142	152	1	367	Chain	ID=PRO_0000186282;Note=Mitogen-activated protein kinase 12
MAPK12	P53778	206	230	27	311	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK12	P53778	142	152	27	311	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK12	P53778	142	152	142	151	Alternative sequence	ID=VSP_055224;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15461802;Dbxref=PMID:15461802
MAPK12	P53778	206	230	230	230	Natural variant	ID=VAR_042266;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35396905,PMID:17344846
MAPK12	P53778	142	152	127	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM8
MAPK12	P53778	206	230	207	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM8
MAPK13	O15264	139	149	1	365	Chain	ID=PRO_0000186286;Note=Mitogen-activated protein kinase 13
MAPK13	O15264	139	149	25	308	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK13	O15264	139	149	124	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNO
NGLY1	Q96IV0	420	475	2	654	Chain	ID=PRO_0000248971;Note=Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
NGLY1	Q96IV0	420	475	454	654	Domain	Note=PAW;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00731
NGLY1	Q96IV0	420	475	1	523	Alternative sequence	ID=VSP_020343;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
ABCB1	P08183	799	827	1	1280	Chain	ID=PRO_0000093332;Note=Multidrug resistance protein 1
ABCB1	P08183	737	773	1	1280	Chain	ID=PRO_0000093332;Note=Multidrug resistance protein 1
ABCB1	P08183	518	575	1	1280	Chain	ID=PRO_0000093332;Note=Multidrug resistance protein 1
ABCB1	P08183	408	450	1	1280	Chain	ID=PRO_0000093332;Note=Multidrug resistance protein 1
ABCB1	P08183	333	371	1	1280	Chain	ID=PRO_0000093332;Note=Multidrug resistance protein 1
ABCB1	P08183	113	176	1	1280	Chain	ID=PRO_0000093332;Note=Multidrug resistance protein 1
ABCB1	P08183	113	176	68	116	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	113	176	117	137	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	113	176	138	186	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	333	371	331	352	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	518	575	353	711	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	408	450	353	711	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	333	371	353	711	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	737	773	733	756	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	737	773	757	777	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	799	827	778	832	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB1	P08183	333	371	51	357	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	113	176	51	357	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	518	575	392	628	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB1	P08183	408	450	392	628	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB1	P08183	799	827	711	1000	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	737	773	711	1000	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB1	P08183	408	450	427	434	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB1	P08183	113	176	113	177	Alternative sequence	ID=VSP_055769;Note=In isoform 2. RYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
ABCB1	P08183	518	575	566	566	Natural variant	ID=VAR_022277;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs28381902
ABCB1	P08183	799	827	801	801	Natural variant	ID=VAR_055428;Note=V->M;Dbxref=dbSNP:rs2235039
ABCB1	P08183	333	371	336	336	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB1	P08183	113	176	106	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	113	176	160	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	113	176	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	113	176	171	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	333	371	328	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	333	371	363	370	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	408	450	410	412	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	408	450	414	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	408	450	422	426	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	408	450	433	440	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	408	450	447	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	518	575	516	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	518	575	533	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	518	575	550	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	518	575	559	561	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	518	575	563	575	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	737	773	724	739	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	737	773	741	743	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	737	773	748	796	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	799	827	801	804	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	799	827	806	808	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB1	P08183	799	827	811	829	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C0V
ABCB4	P21439	1169	1218	1	1286	Chain	ID=PRO_0000093333;Note=Phosphatidylcholine translocator ABCB4
ABCB4	P21439	1093	1169	1	1286	Chain	ID=PRO_0000093333;Note=Phosphatidylcholine translocator ABCB4
ABCB4	P21439	928	974	1	1286	Chain	ID=PRO_0000093333;Note=Phosphatidylcholine translocator ABCB4
ABCB4	P21439	826	894	1	1286	Chain	ID=PRO_0000093333;Note=Phosphatidylcholine translocator ABCB4
ABCB4	P21439	737	772	1	1286	Chain	ID=PRO_0000093333;Note=Phosphatidylcholine translocator ABCB4
ABCB4	P21439	115	178	1	1286	Chain	ID=PRO_0000093333;Note=Phosphatidylcholine translocator ABCB4
ABCB4	P21439	115	178	74	118	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	115	178	119	139	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	115	178	140	188	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	737	772	733	755	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	737	772	756	776	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	826	894	777	831	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	826	894	832	852	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	826	894	853	853	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	826	894	854	873	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	928	974	874	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	826	894	874	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	928	974	934	956	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	928	974	957	972	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	928	974	973	994	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	1169	1218	995	1286	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	1093	1169	995	1286	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCB4	P21439	115	178	57	359	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	928	974	711	999	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	826	894	711	999	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	737	772	711	999	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB4	P21439	1169	1218	1034	1279	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB4	P21439	1093	1169	1034	1279	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB4	P21439	928	974	929	975	Alternative sequence	ID=VSP_046258;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB4	P21439	1093	1169	1094	1100	Alternative sequence	ID=VSP_023263;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2906314;Dbxref=PMID:2906314
ABCB4	P21439	115	178	124	124	Natural variant	ID=VAR_073737;Note=In GBD1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23533021;Dbxref=PMID:23533021
ABCB4	P21439	115	178	126	126	Natural variant	ID=VAR_073738;Note=In PFIC3. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17726488;Dbxref=dbSNP:rs1021988376,PMID:17726488
ABCB4	P21439	115	178	138	138	Natural variant	ID=VAR_043080;Note=In PFIC3. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11313315;Dbxref=dbSNP:rs72552781,PMID:11313315
ABCB4	P21439	115	178	150	150	Natural variant	ID=VAR_043081;Note=In ICP3. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12746424;Dbxref=dbSNP:rs757693457,PMID:12746424
ABCB4	P21439	115	178	154	154	Natural variant	ID=VAR_073739;Note=In GBD1. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23533021;Dbxref=PMID:23533021
ABCB4	P21439	115	178	165	165	Natural variant	ID=VAR_043082;Note=In GBD1. F->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12891548,ECO:0000269|PubMed:23533021;Dbxref=PMID:12891548,PMID:23533021
ABCB4	P21439	115	178	175	175	Natural variant	ID=VAR_023501;Note=Found in patients with gallbladder and cholestasis%3B unknown pathological significance. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313316,ECO:0000269|PubMed:12891548,ECO:0000269|PubMed:15077010,ECO:0000269|PubMed:16763017,ECO:0000269|PubMed:17264802,ECO:0000269|PubMed:17726488,ECO:0000269|PubMed:22331132,ECO:0000269|PubMed:23533021;Dbxref=dbSNP:rs58238559,PMID:11313316,PMID:12891548,PMID:15077010,PMID:16763017,PMID:17264802,PMID:17726488,PMID:22331132,PMID:23533021
ABCB4	P21439	737	772	737	737	Natural variant	ID=VAR_073769;Note=In PFIC3. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17726488;Dbxref=dbSNP:rs147134978,PMID:17726488
ABCB4	P21439	737	772	742	742	Natural variant	ID=VAR_043098;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12891548;Dbxref=PMID:12891548
ABCB4	P21439	737	772	762	762	Natural variant	ID=VAR_043099;Note=In ICP3. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15077010;Dbxref=PMID:15077010
ABCB4	P21439	737	772	764	764	Natural variant	ID=VAR_043100;Note=In a heterozygous patient with risperidone-induced cholestasis. I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17264802;Dbxref=PMID:17264802
ABCB4	P21439	826	894	840	840	Natural variant	ID=VAR_073770;Note=In PFIC3. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17726488;Dbxref=PMID:17726488
ABCB4	P21439	928	974	934	934	Natural variant	ID=VAR_043102;Note=Found in patients with gallbladder and cholestasis%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12891548,ECO:0000269|PubMed:23533021;Dbxref=dbSNP:rs61730509,PMID:12891548,PMID:23533021
ABCB4	P21439	928	974	954	954	Natural variant	ID=VAR_073771;Note=In PFIC3. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17726488;Dbxref=dbSNP:rs779829759,PMID:17726488
ABCB4	P21439	928	974	964	964	Natural variant	ID=VAR_073772;Note=Requires 2 nucleotide substitutions%3B found in patients with cholangitis%3B unknown pathological significance. V->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22331132;Dbxref=PMID:22331132
ABCB4	P21439	1093	1169	1125	1125	Natural variant	ID=VAR_073776;Note=In PFIC3%3B alters efflux activity for PC. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24594635;Dbxref=PMID:24594635
ABCB4	P21439	1093	1169	1161	1161	Natural variant	ID=VAR_043105;Note=In GBD1. Missing
ABCB4	P21439	1093	1169	1168	1168	Natural variant	ID=VAR_023504;Note=In GBD1. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313316,ECO:0000269|PubMed:12891548;Dbxref=dbSNP:rs121918442,PMID:11313316,PMID:12891548
ABCB4	P21439	1169	1218	1183	1183	Natural variant	ID=VAR_079612;Note=In GBD1%3B severely reduced phosphatidylcholine transporter activity%3B does not alter plasma membrane location. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28012258;Dbxref=PMID:28012258
ABCB4	P21439	1169	1218	1185	1185	Natural variant	ID=VAR_079613;Note=In GBD1%3B loss of phosphatidylcholine transporter activity%3B does not alter plasma membrane location. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28012258;Dbxref=PMID:28012258
ABCB4	P21439	1169	1218	1193	1193	Natural variant	ID=VAR_073777;Note=In PFIC3. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17726488;Dbxref=PMID:17726488
ABCB4	P21439	928	974	953	953	Mutagenesis	Note=Accumulates predominantly in intracellular compartments with only a small fraction at the plasma membrane and inhibits partially the efflux activity for PC. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24806754;Dbxref=PMID:24806754
MED30	Q96HR3	112	147	2	178	Chain	ID=PRO_0000239406;Note=Mediator of RNA polymerase II transcription subunit 30
MED30	Q96HR3	112	147	133	173	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MED30	Q96HR3	112	147	113	147	Alternative sequence	ID=VSP_053904;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MFSD10	Q14728	387	417	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	371	387	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	177	231	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	124	177	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	387	417	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	371	387	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	177	231	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	124	177	1	455	Chain	ID=PRO_0000324658;Note=Major facilitator superfamily domain-containing protein 10
MFSD10	Q14728	124	177	113	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	124	177	113	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	124	177	148	168	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	124	177	148	168	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	177	231	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	124	177	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	177	231	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	124	177	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	177	231	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	177	231	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	371	387	359	379	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD10	Q14728	371	387	359	379	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MIER2	Q8N344	81	123	1	545	Chain	ID=PRO_0000313678;Note=Mesoderm induction early response protein 2
MIER2	Q8N344	81	123	104	104	Natural variant	ID=VAR_037696;Note=D->N;Dbxref=dbSNP:rs10421231
MMP19	Q99542	255	298	98	508	Chain	ID=PRO_0000028827;Note=Matrix metalloproteinase-19
MMP19	Q99542	173	255	98	508	Chain	ID=PRO_0000028827;Note=Matrix metalloproteinase-19
MMP19	Q99542	255	298	286	333	Repeat	Note=Hemopexin 1
MMP19	Q99542	255	298	265	271	Compositional bias	Note=Poly-Glu
MMP19	Q99542	173	255	213	213	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
MMP19	Q99542	173	255	212	212	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
MMP19	Q99542	173	255	216	216	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
MMP19	Q99542	173	255	222	222	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
MMP19	Q99542	255	298	289	472	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP19	Q99542	255	298	1	286	Alternative sequence	ID=VSP_005457;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
MMP19	Q99542	173	255	1	286	Alternative sequence	ID=VSP_005457;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
MMP19	Q99542	255	298	64	508	Alternative sequence	ID=VSP_041894;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
MMP19	Q99542	173	255	64	508	Alternative sequence	ID=VSP_041894;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
MMP19	Q99542	255	298	174	255	Alternative sequence	ID=VSP_054573;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MMP19	Q99542	173	255	174	255	Alternative sequence	ID=VSP_054573;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MMP19	Q99542	255	298	287	298	Alternative sequence	ID=VSP_005458;Note=In isoform 2. DPCSSELDAMML->MGVTWDFSMSNG;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
MMP19	Q99542	173	255	245	245	Natural variant	ID=VAR_054006;Note=P->S;Dbxref=dbSNP:rs1056784
MAPK4	P31152	230	284	1	587	Chain	ID=PRO_0000186254;Note=Mitogen-activated protein kinase 4
MAPK4	P31152	230	284	20	312	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MMP2	P08253	176	219	110	660	Chain	ID=PRO_0000028715;Note=72 kDa type IV collagenase
MMP2	P08253	335	393	110	660	Chain	ID=PRO_0000028715;Note=72 kDa type IV collagenase
MMP2	P08253	393	445	110	660	Chain	ID=PRO_0000028715;Note=72 kDa type IV collagenase
MMP2	P08253	393	445	445	660	Chain	ID=PRO_0000391626;Note=PEX
MMP2	P08253	335	393	344	392	Domain	Note=Fibronectin type-II 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
MMP2	P08253	176	219	110	221	Region	Note=Collagenase-like 1
MMP2	P08253	335	393	222	396	Region	Note=Collagen-binding
MMP2	P08253	393	445	222	396	Region	Note=Collagen-binding
MMP2	P08253	393	445	397	465	Region	Note=Collagenase-like 2
MMP2	P08253	393	445	414	660	Region	Note=Required for inhibitor TIMP2 binding
MMP2	P08253	393	445	404	404	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
MMP2	P08253	176	219	178	178	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	180	180	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	185	185	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	186	186	Metal binding	Note=Calcium 3%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	193	193	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	200	200	Metal binding	Note=Calcium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	202	202	Metal binding	Note=Calcium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	204	204	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	206	206	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	208	208	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	209	209	Metal binding	Note=Calcium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	176	219	211	211	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	393	445	403	403	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	393	445	407	407	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	393	445	413	413	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
MMP2	P08253	335	393	349	375	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
MMP2	P08253	335	393	363	390	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
MMP2	P08253	176	219	210	210	Natural variant	ID=VAR_032424;Note=D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11431697;Dbxref=PMID:11431697
MMP2	P08253	393	445	400	400	Natural variant	ID=VAR_054996;Note=In MONA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16542393;Dbxref=PMID:16542393
MMP2	P08253	393	445	404	404	Natural variant	ID=VAR_032425;Note=In MONA. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15691365;Dbxref=dbSNP:rs121912955,PMID:15691365
MMP2	P08253	176	219	179	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	176	219	186	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	176	219	192	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	176	219	197	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	176	219	200	203	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	176	219	205	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	176	219	209	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HOV
MMP2	P08253	176	219	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	335	393	338	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GXD
MMP2	P08253	335	393	342	346	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	335	393	351	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	335	393	358	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	335	393	369	371	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	335	393	374	379	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	335	393	381	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	335	393	387	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAK
MMP2	P08253	393	445	394	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	393	445	397	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	393	445	422	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
MMP2	P08253	393	445	435	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AYU
NQO1	P15559	139	173	1	274	Chain	ID=PRO_0000071622;Note=NAD(P)H dehydrogenase [quinone] 1
NQO1	P15559	101	139	1	274	Chain	ID=PRO_0000071622;Note=NAD(P)H dehydrogenase [quinone] 1
NQO1	P15559	101	139	104	107	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10543876,ECO:0000269|PubMed:10706635,ECO:0000269|PubMed:11735396;Dbxref=PMID:10543876,PMID:10706635,PMID:11735396
NQO1	P15559	139	173	148	151	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10543876,ECO:0000269|PubMed:10706635,ECO:0000269|PubMed:11735396;Dbxref=PMID:10543876,PMID:10706635,PMID:11735396
NQO1	P15559	101	139	126	128	Region	Note=Substrate binding
NQO1	P15559	139	173	156	156	Binding site	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10543876,ECO:0000269|PubMed:10706635,ECO:0000269|PubMed:11735396;Dbxref=PMID:10543876,PMID:10706635,PMID:11735396
NQO1	P15559	139	173	102	139	Alternative sequence	ID=VSP_044446;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NQO1	P15559	101	139	102	139	Alternative sequence	ID=VSP_044446;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NQO1	P15559	139	173	140	173	Alternative sequence	ID=VSP_042716;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NQO1	P15559	139	173	139	139	Natural variant	ID=VAR_016170;Note=R->W;Dbxref=dbSNP:rs1131341
NQO1	P15559	101	139	139	139	Natural variant	ID=VAR_016170;Note=R->W;Dbxref=dbSNP:rs1131341
NQO1	P15559	101	139	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	101	139	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CET
NQO1	P15559	101	139	111	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	101	139	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	101	139	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H69
NQO1	P15559	101	139	133	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	139	173	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	101	139	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	139	173	142	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	139	173	154	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
NQO1	P15559	139	173	160	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H69
NQO1	P15559	139	173	165	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4A
MERTK	Q12866	252	281	21	999	Chain	ID=PRO_0000024443;Note=Tyrosine-protein kinase Mer
MERTK	Q12866	252	281	21	999	Chain	ID=PRO_0000024443;Note=Tyrosine-protein kinase Mer
MERTK	Q12866	252	281	21	505	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MERTK	Q12866	252	281	21	505	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MERTK	Q12866	252	281	197	273	Domain	Note=Ig-like C2-type 2
MERTK	Q12866	252	281	197	273	Domain	Note=Ig-like C2-type 2
MERTK	Q12866	252	281	218	262	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
MERTK	Q12866	252	281	218	262	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
MERTK	Q12866	252	281	274	274	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MERTK	Q12866	252	281	274	274	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
METTL4	Q8N3J2	132	153	1	472	Chain	ID=PRO_0000251225;Note=Methyltransferase-like protein 4
METTL4	Q8N3J2	132	153	153	153	Sequence conflict	Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
OGN	P20774	89	142	21	298	Chain	ID=PRO_0000032760;Note=Mimecan
OGN	P20774	89	142	21	298	Chain	ID=PRO_0000032760;Note=Mimecan
OGN	P20774	89	142	112	131	Repeat	Note=LRR 1
OGN	P20774	89	142	112	131	Repeat	Note=LRR 1
OGN	P20774	89	142	132	155	Repeat	Note=LRR 2
OGN	P20774	89	142	132	155	Repeat	Note=LRR 2
OGN	P20774	89	142	94	106	Compositional bias	Note=Cys-rich
OGN	P20774	89	142	94	106	Compositional bias	Note=Cys-rich
MINK1	Q8N4C8	522	580	1	1332	Chain	ID=PRO_0000086329;Note=Misshapen-like kinase 1
MINK1	Q8N4C8	696	732	1	1332	Chain	ID=PRO_0000086329;Note=Misshapen-like kinase 1
MINK1	Q8N4C8	972	1028	1	1332	Chain	ID=PRO_0000086329;Note=Misshapen-like kinase 1
MINK1	Q8N4C8	972	1028	1019	1306	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MINK1	Q8N4C8	972	1028	866	1332	Region	Note=Mediates interaction with RAP2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18930710;Dbxref=PMID:18930710
MINK1	Q8N4C8	522	580	542	729	Compositional bias	Note=Pro-rich
MINK1	Q8N4C8	696	732	542	729	Compositional bias	Note=Pro-rich
MINK1	Q8N4C8	696	732	701	701	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MINK1	Q8N4C8	696	732	696	732	Alternative sequence	ID=VSP_007059;Note=In isoform 1%2C isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10708748;Dbxref=PMID:10708748
MINK1	Q8N4C8	972	1028	1010	1010	Natural variant	ID=VAR_046061;Note=In a gastric adenocarcinoma sample%3B somatic mutation. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
RHOT2	Q8IXI1	74	92	1	618	Chain	ID=PRO_0000239318;Note=Mitochondrial Rho GTPase 2
RHOT2	Q8IXI1	180	213	1	618	Chain	ID=PRO_0000239318;Note=Mitochondrial Rho GTPase 2
RHOT2	Q8IXI1	442	468	1	618	Chain	ID=PRO_0000239318;Note=Mitochondrial Rho GTPase 2
RHOT2	Q8IXI1	468	509	1	618	Chain	ID=PRO_0000239318;Note=Mitochondrial Rho GTPase 2
RHOT2	Q8IXI1	74	92	1	592	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOT2	Q8IXI1	180	213	1	592	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOT2	Q8IXI1	442	468	1	592	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOT2	Q8IXI1	468	509	1	592	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOT2	Q8IXI1	74	92	1	142	Domain	Note=Miro 1
RHOT2	Q8IXI1	180	213	184	219	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RHOT2	Q8IXI1	442	468	410	618	Domain	Note=Miro 2
RHOT2	Q8IXI1	468	509	410	618	Domain	Note=Miro 2
RHOT2	Q8IXI1	180	213	197	208	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RHOT2	Q8IXI1	442	468	459	463	Nucleotide binding	Note=GTP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOT2	Q8IXI1	74	92	1	127	Alternative sequence	ID=VSP_019162;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
RHOT2	Q8IXI1	442	468	341	618	Alternative sequence	ID=VSP_019164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
RHOT2	Q8IXI1	468	509	341	618	Alternative sequence	ID=VSP_019164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
RHOT2	Q8IXI1	442	468	453	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUT
RHOT2	Q8IXI1	442	468	463	473	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUT
RHOT2	Q8IXI1	468	509	463	473	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUT
RHOT2	Q8IXI1	468	509	476	479	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUT
RHOT2	Q8IXI1	468	509	486	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUT
RHOT2	Q8IXI1	468	509	500	511	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KUT
MICU3	Q86XE3	283	296	1	530	Chain	ID=PRO_0000251230;Note=Calcium uptake protein 3%2C mitochondrial
MICU3	Q86XE3	296	328	1	530	Chain	ID=PRO_0000251230;Note=Calcium uptake protein 3%2C mitochondrial
MIDN	Q504T8	107	128	1	468	Chain	ID=PRO_0000287536;Note=Midnolin
MIDN	Q504T8	128	232	1	468	Chain	ID=PRO_0000287536;Note=Midnolin
MIDN	Q504T8	285	376	1	468	Chain	ID=PRO_0000287536;Note=Midnolin
MIDN	Q504T8	107	128	1	468	Chain	ID=PRO_0000287536;Note=Midnolin
MIDN	Q504T8	128	232	1	468	Chain	ID=PRO_0000287536;Note=Midnolin
MIDN	Q504T8	285	376	1	468	Chain	ID=PRO_0000287536;Note=Midnolin
MAPK1IP1L	Q8NDC0	6	242	2	245	Chain	ID=PRO_0000209890;Note=MAPK-interacting and spindle-stabilizing protein-like
MAPK1IP1L	Q8NDC0	6	242	27	241	Compositional bias	Note=Pro-rich
MAPK1IP1L	Q8NDC0	6	242	6	6	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAPK1IP1L	Q8NDC0	6	242	15	15	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163
SLC16A14	Q7RTX9	134	460	1	510	Chain	ID=PRO_0000288923;Note=Monocarboxylate transporter 14
SLC16A14	Q7RTX9	86	134	1	510	Chain	ID=PRO_0000288923;Note=Monocarboxylate transporter 14
SLC16A14	Q7RTX9	86	134	74	94	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	86	134	103	123	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	127	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	86	134	127	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	191	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	315	335	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	353	373	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	379	399	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	408	428	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	443	463	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A14	Q7RTX9	134	460	1	174	Alternative sequence	ID=VSP_025826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC16A14	Q7RTX9	86	134	1	174	Alternative sequence	ID=VSP_025826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC16A14	Q7RTX9	134	460	209	209	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC16A8	O95907	119	399	1	504	Chain	ID=PRO_0000211390;Note=Monocarboxylate transporter 3
SLC16A8	O95907	119	399	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	137	143	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	144	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	165	172	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	173	193	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	194	254	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	255	275	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	276	289	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	290	310	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	311	318	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	319	335	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	336	342	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	343	363	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	364	376	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	377	397	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	398	410	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A8	O95907	119	399	235	235	Natural variant	ID=VAR_060107;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10493836;Dbxref=dbSNP:rs4289289,PMID:10493836
METTL2A	Q96IZ6	305	327	2	378	Chain	ID=PRO_0000204452;Note=Methyltransferase-like protein 2A
METTL16	Q86W50	266	296	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
METTL16	Q86W50	109	156	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
METTL16	Q86W50	0	42	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
METTL16	Q86W50	266	296	289	400	Region	Note=VCR 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28525753;Dbxref=PMID:28525753
METTL16	Q86W50	109	156	110	110	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2H00,ECO:0000269|Ref.13
METTL16	Q86W50	109	156	133	133	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2H00,ECO:0000269|Ref.13
METTL16	Q86W50	266	296	225	562	Alternative sequence	ID=VSP_029341;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
METTL16	Q86W50	0	42	39	39	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
METTL16	Q86W50	0	42	5	7	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	0	42	12	15	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	0	42	20	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	0	42	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	105	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	112	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	116	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	128	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	136	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	152	154	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	155	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	266	296	268	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	266	296	280	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
MEST	Q5EB52	87	113	1	335	Chain	ID=PRO_0000284418;Note=Mesoderm-specific transcript homolog protein
MEST	Q5EB52	216	249	1	335	Chain	ID=PRO_0000284418;Note=Mesoderm-specific transcript homolog protein
MEST	Q5EB52	87	113	71	310	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEST	Q5EB52	216	249	71	310	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEST	Q5EB52	87	113	98	103	Motif	Note=RVIALD
MEST	Q5EB52	216	249	218	251	Alternative sequence	ID=VSP_024533;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEST	Q5EB52	87	113	90	90	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
MEST	Q5EB52	216	249	222	222	Sequence conflict	Note=G->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTR	Q99707	83	113	1	1265	Chain	ID=PRO_0000204530;Note=Methionine synthase
MTR	Q99707	203	223	1	1265	Chain	ID=PRO_0000204530;Note=Methionine synthase
MTR	Q99707	396	443	1	1265	Chain	ID=PRO_0000204530;Note=Methionine synthase
MTR	Q99707	505	565	1	1265	Chain	ID=PRO_0000204530;Note=Methionine synthase
MTR	Q99707	681	732	1	1265	Chain	ID=PRO_0000204530;Note=Methionine synthase
MTR	Q99707	1068	1135	1	1265	Chain	ID=PRO_0000204530;Note=Methionine synthase
MTR	Q99707	83	113	19	338	Domain	Note=Hcy-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00333
MTR	Q99707	203	223	19	338	Domain	Note=Hcy-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00333
MTR	Q99707	396	443	371	632	Domain	Note=Pterin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00334
MTR	Q99707	505	565	371	632	Domain	Note=Pterin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00334
MTR	Q99707	681	732	662	759	Domain	Note=B12-binding N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00667
MTR	Q99707	1068	1135	923	1265	Domain	Note=AdoMet activation;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00346
MTR	Q99707	505	565	537	537	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:4CCZ,ECO:0000305|Ref.11
MTR	Q99707	681	732	682	732	Alternative sequence	ID=VSP_057283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTR	Q99707	1068	1135	1071	1071	Mutagenesis	Note=Decreases binding to MTRR%3B when associated with E-963. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17288554;Dbxref=PMID:17288554
MTR	Q99707	83	113	75	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	83	113	92	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	83	113	102	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	83	113	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	83	113	111	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	203	223	199	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	203	223	214	216	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	203	223	222	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	396	443	395	407	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	396	443	411	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	396	443	424	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	396	443	439	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	505	565	509	527	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	505	565	531	533	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	505	565	534	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	505	565	548	552	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	505	565	553	567	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCZ
MTR	Q99707	1068	1135	1082	1085	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O2K
MTR	Q99707	1068	1135	1089	1091	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O2K
MTR	Q99707	1068	1135	1095	1106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O2K
MTR	Q99707	1068	1135	1107	1116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O2K
MTR	Q99707	1068	1135	1120	1147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O2K
METRN	Q9UJH8	168	188	24	293	Chain	ID=PRO_0000021680;Note=Meteorin
METRN	Q9UJH8	168	188	171	242	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
METRN	Q9UJH8	168	188	174	266	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
METRN	Q9UJH8	168	188	184	288	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
MET	P08581	962	1009	25	1390	Chain	ID=PRO_0000024440;Note=Hepatocyte growth factor receptor
MET	P08581	962	1009	956	1390	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MET	P08581	962	1009	1003	1003	Site	Note=Required for ligand-induced CBL-mediated ubiquitination;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244174;Dbxref=PMID:12244174
MET	P08581	962	1009	1009	1010	Site	Note=Breakpoint for translocation to form TPR-MET oncogene
MET	P08581	962	1009	966	966	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
MET	P08581	962	1009	977	977	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
MET	P08581	962	1009	990	990	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MET	P08581	962	1009	997	997	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MET	P08581	962	1009	1000	1000	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MET	P08581	962	1009	1003	1003	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
MET	P08581	962	1009	765	1390	Alternative sequence	ID=VSP_042448;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MET	P08581	962	1009	964	1010	Natural variant	ID=VAR_076584;Note=In OSFD%3B loss of CBL-mediated destabilization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26637977;Dbxref=PMID:26637977
MET	P08581	962	1009	970	970	Natural variant	ID=VAR_032482;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17053076,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34589476,PMID:17053076,PMID:17344846
MET	P08581	962	1009	991	991	Natural variant	ID=VAR_032483;Note=In gastric cancer%3B prolonged tyrosine phosphorylation in response to HGF/SF%3B transforming activity in athymic nude mice. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042681;Dbxref=dbSNP:rs768678989,PMID:11042681
MET	P08581	962	1009	992	992	Natural variant	ID=VAR_032484;Note=Found in a case of cancer of unknown primary origin%3B the mutated receptor is still functional and can sustain the transformed phenotype%3B somatic mutation. T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11042681,ECO:0000269|PubMed:17053076,ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:20949619;Dbxref=dbSNP:rs56391007,PMID:11042681,PMID:17053076,PMID:17344846,PMID:20949619
MET	P08581	962	1009	1003	1003	Natural variant	ID=VAR_076585;Note=Probable disease-associated mutation found in lesional sample from a patient with sporadically occurring%2C unilateral osteofibrous dysplasia%3B somatic mutation%3B complete loss of ligand-induced CBL-mediated ubiquitination%2C resulting in protein stabilization. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244174;Dbxref=PMID:12244174
MFN1	Q8IWA4	408	443	1	741	Chain	ID=PRO_0000127672;Note=Mitofusin-1
MFN1	Q8IWA4	671	715	1	741	Chain	ID=PRO_0000127672;Note=Mitofusin-1
MFN1	Q8IWA4	408	443	1	741	Chain	ID=PRO_0000127672;Note=Mitofusin-1
MFN1	Q8IWA4	671	715	1	741	Chain	ID=PRO_0000127672;Note=Mitofusin-1
MFN1	Q8IWA4	408	443	1	584	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	408	443	1	584	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	671	715	630	741	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	671	715	630	741	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	671	715	703	734	Region	Note=Part of a helix bundle domain%2C formed by helices from N-terminal and C-terminal regions;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:28114303;Dbxref=PMID:16959974,PMID:28114303
MFN1	Q8IWA4	671	715	703	734	Region	Note=Part of a helix bundle domain%2C formed by helices from N-terminal and C-terminal regions;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:28114303;Dbxref=PMID:16959974,PMID:28114303
MFN1	Q8IWA4	408	443	371	408	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	408	443	371	408	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	671	715	679	734	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	671	715	679	734	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN1	Q8IWA4	408	443	371	741	Alternative sequence	ID=VSP_010363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFN1	Q8IWA4	671	715	371	741	Alternative sequence	ID=VSP_010363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFN1	Q8IWA4	408	443	371	741	Alternative sequence	ID=VSP_010363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFN1	Q8IWA4	671	715	371	741	Alternative sequence	ID=VSP_010363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFN1	Q8IWA4	408	443	415	415	Natural variant	ID=VAR_036115;Note=In a colorectal cancer sample%3B somatic mutation. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MFN1	Q8IWA4	408	443	415	415	Natural variant	ID=VAR_036115;Note=In a colorectal cancer sample%3B somatic mutation. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MFN1	Q8IWA4	671	715	705	705	Mutagenesis	Note=Impairs protein folding. Decreases GTPase activity. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27920125,ECO:0000269|PubMed:28114303;Dbxref=PMID:27920125,PMID:28114303
MFN1	Q8IWA4	671	715	705	705	Mutagenesis	Note=Impairs protein folding. Decreases GTPase activity. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27920125,ECO:0000269|PubMed:28114303;Dbxref=PMID:27920125,PMID:28114303
MFN1	Q8IWA4	671	715	688	688	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
MFN1	Q8IWA4	671	715	688	688	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
MFN1	Q8IWA4	408	443	410	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GO4
MFN1	Q8IWA4	408	443	410	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GO4
MFSD11	O43934	227	249	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	249	291	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	227	249	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	249	291	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	227	249	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	249	291	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	227	249	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	249	291	1	449	Chain	ID=PRO_0000305019;Note=UNC93-like protein MFSD11
MFSD11	O43934	227	249	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	227	249	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	227	249	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	227	249	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	277	297	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	277	297	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	277	297	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD11	O43934	249	291	277	297	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAPK3	P27361	258	302	2	379	Chain	ID=PRO_0000186251;Note=Mitogen-activated protein kinase 3
MAPK3	P27361	181	220	2	379	Chain	ID=PRO_0000186251;Note=Mitogen-activated protein kinase 3
MAPK3	P27361	258	302	42	330	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK3	P27361	181	220	42	330	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPK3	P27361	181	220	202	204	Motif	Note=TXY
MAPK3	P27361	181	220	198	198	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
MAPK3	P27361	181	220	202	202	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
MAPK3	P27361	181	220	204	204	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:18983981,ECO:0000269|PubMed:19494114;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163,PMID:18983981,PMID:19494114
MAPK3	P27361	181	220	207	207	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
MAPK3	P27361	258	302	259	302	Alternative sequence	ID=VSP_041906;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MAPK3	P27361	181	220	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	181	220	193	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	181	220	208	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	181	220	213	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	181	220	216	218	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	258	302	250	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	258	302	266	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	258	302	275	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	258	302	292	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MAPK3	P27361	258	302	301	310	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QTB
MDM1	Q8TC05	657	677	1	714	Chain	ID=PRO_0000299059;Note=Nuclear protein MDM1
MDM1	Q8TC05	166	211	1	714	Chain	ID=PRO_0000299059;Note=Nuclear protein MDM1
MDM1	Q8TC05	166	211	189	195	Motif	Note=ST]-E-Y-X(3)-F motif 2%3B required for efficient microtubule binding and stabilization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26337392;Dbxref=PMID:26337392
MDM1	Q8TC05	657	677	70	714	Alternative sequence	ID=VSP_027545;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MDM1	Q8TC05	166	211	70	714	Alternative sequence	ID=VSP_027545;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MDM1	Q8TC05	166	211	167	222	Alternative sequence	ID=VSP_027546;Note=In isoform 2. LDRLLRKKAGLTVVPSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPP->VGIFTAFLFKSIEFFIGFIVISVILHFVFQNFPLLFSCLMSIRIVDNRLLTLVIVN;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MDM1	Q8TC05	166	211	167	211	Alternative sequence	ID=VSP_046400;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MDM1	Q8TC05	657	677	223	714	Alternative sequence	ID=VSP_027547;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MDM1	Q8TC05	166	211	189	195	Mutagenesis	Note=Loss of microtubule binding%2C no loss of centrosomal localization%2C little effect on microtubule stability%2C loss of ability to block centriole reduplication and defective blocking of normal centriole duplication%3B when associated with 9-A--A-15%3B 232-A--A-238 and 306-A--A-312. SEYQRQF->AAAQRQA
SLC24A1	O60721	630	648	1	1099	Chain	ID=PRO_0000223303;Note=Sodium/potassium/calcium exchanger 1
SLC24A1	O60721	931	961	1	1099	Chain	ID=PRO_0000223303;Note=Sodium/potassium/calcium exchanger 1
SLC24A1	O60721	630	648	607	907	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A1	O60721	931	961	929	935	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A1	O60721	931	961	936	956	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A1	O60721	931	961	957	971	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A1	O60721	630	648	631	648	Alternative sequence	ID=VSP_006160;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9478004,ECO:0000303|PubMed:9734811;Dbxref=PMID:9478004,PMID:9734811
SLC24A1	O60721	931	961	932	961	Alternative sequence	ID=VSP_054491;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEGF6	O75095	1505	1521	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	1462	1505	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	1419	1462	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	1160	1204	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	1031	1074	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	988	1031	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	902	945	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	815	858	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	771	815	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	684	729	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	509	553	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	371	411	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	325	371	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	243	284	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	160	201	31	1541	Chain	ID=PRO_0000007524;Note=Multiple epidermal growth factor-like domains protein 6
MEGF6	O75095	160	201	161	201	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	243	284	238	284	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	325	371	285	325	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	325	371	335	370	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	371	411	375	411	Domain	Note=EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	509	553	516	552	Domain	Note=EGF-like 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	771	815	783	814	Domain	Note=EGF-like 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	815	858	822	857	Domain	Note=EGF-like 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	902	945	909	944	Domain	Note=EGF-like 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	988	1031	995	1030	Domain	Note=EGF-like 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	1031	1074	1038	1073	Domain	Note=EGF-like 19;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	1462	1505	1469	1504	Domain	Note=EGF-like 27;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF6	O75095	243	284	252	252	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF6	O75095	160	201	165	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	160	201	172	185	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	160	201	187	200	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	243	284	242	255	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	243	284	248	268	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	243	284	270	283	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	509	553	520	533	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	509	553	527	540	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	509	553	542	551	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	771	815	786	795	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	771	815	789	802	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	771	815	804	813	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	815	858	826	838	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	815	858	832	845	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	815	858	847	856	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	902	945	913	925	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	902	945	919	932	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	902	945	934	943	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	988	1031	999	1011	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	988	1031	1005	1018	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	988	1031	1020	1029	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	1031	1074	1042	1054	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	1031	1074	1048	1061	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	1031	1074	1063	1072	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	1462	1505	1473	1485	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	1462	1505	1479	1492	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	1462	1505	1494	1503	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF6	O75095	160	201	160	160	Alternative sequence	ID=VSP_037741;Note=In isoform 2. Y->MGASRDRGLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQRP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9693030;Dbxref=PMID:9693030
MEGF6	O75095	1031	1074	989	1075	Alternative sequence	ID=VSP_037742;Note=In isoform 2. TCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9693030;Dbxref=PMID:9693030
MEGF6	O75095	988	1031	989	1075	Alternative sequence	ID=VSP_037742;Note=In isoform 2. TCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9693030;Dbxref=PMID:9693030
MEGF6	O75095	1160	1204	1161	1205	Alternative sequence	ID=VSP_037743;Note=In isoform 2. ACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9693030;Dbxref=PMID:9693030
MEGF6	O75095	1419	1462	1377	1454	Alternative sequence	ID=VSP_037744;Note=In isoform 2. PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9693030;Dbxref=PMID:9693030
MEGF6	O75095	684	729	688	688	Natural variant	ID=VAR_059260;Note=L->P;Dbxref=dbSNP:rs2821008
MEGF6	O75095	902	945	916	916	Natural variant	ID=VAR_058362;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9693030;Dbxref=dbSNP:rs7553399,PMID:9693030
MED17	Q9NVC6	286	337	1	651	Chain	ID=PRO_0000079359;Note=Mediator of RNA polymerase II transcription subunit 17
MED17	Q9NVC6	443	488	1	651	Chain	ID=PRO_0000079359;Note=Mediator of RNA polymerase II transcription subunit 17
MED17	Q9NVC6	286	337	146	651	Alternative sequence	ID=VSP_028116;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MED17	Q9NVC6	443	488	146	651	Alternative sequence	ID=VSP_028116;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
METTL6	Q8TCB7	120	177	1	284	Chain	ID=PRO_0000204454;Note=Methyltransferase-like protein 6
METTL6	Q8TCB7	75	120	1	284	Chain	ID=PRO_0000204454;Note=Methyltransferase-like protein 6
METTL6	Q8TCB7	120	177	1	284	Chain	ID=PRO_0000204454;Note=Methyltransferase-like protein 6
METTL6	Q8TCB7	75	120	1	284	Chain	ID=PRO_0000204454;Note=Methyltransferase-like protein 6
MFAP2	P55001	12	42	1	17	Signal peptide	Note=Or 19;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFAP2	P55001	51	80	18	183	Chain	ID=PRO_0000018682;Note=Microfibrillar-associated protein 2
MFAP2	P55001	12	42	18	183	Chain	ID=PRO_0000018682;Note=Microfibrillar-associated protein 2
MFAP2	P55001	51	80	59	73	Compositional bias	Note=Gln/Glu-rich
MFAP2	P55001	12	42	18	18	Modified residue	Note=Pyrrolidone carboxylic acid;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27424
MFAP2	P55001	12	42	13	42	Alternative sequence	ID=VSP_042779;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
MFAP2	P55001	12	42	13	13	Alternative sequence	ID=VSP_042780;Note=In isoform A'. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MFF	Q9GZY8	173	197	1	342	Chain	ID=PRO_0000289184;Note=Mitochondrial fission factor
MFF	Q9GZY8	198	250	1	342	Chain	ID=PRO_0000289184;Note=Mitochondrial fission factor
MFF	Q9GZY8	251	270	1	342	Chain	ID=PRO_0000289184;Note=Mitochondrial fission factor
MFF	Q9GZY8	173	197	1	322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFF	Q9GZY8	198	250	1	322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFF	Q9GZY8	251	270	1	322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFF	Q9GZY8	198	250	200	200	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MFF	Q9GZY8	198	250	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MFF	Q9GZY8	198	250	229	229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MFF	Q9GZY8	198	250	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
MFF	Q9GZY8	173	197	174	271	Alternative sequence	ID=VSP_025955;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MFF	Q9GZY8	198	250	174	271	Alternative sequence	ID=VSP_025955;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MFF	Q9GZY8	251	270	174	271	Alternative sequence	ID=VSP_025955;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MFF	Q9GZY8	173	197	174	251	Alternative sequence	ID=VSP_025956;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MFF	Q9GZY8	198	250	174	251	Alternative sequence	ID=VSP_025956;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MFF	Q9GZY8	251	270	174	251	Alternative sequence	ID=VSP_025956;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MFF	Q9GZY8	173	197	174	198	Alternative sequence	ID=VSP_025957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFF	Q9GZY8	198	250	174	198	Alternative sequence	ID=VSP_025957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MFF	Q9GZY8	198	250	199	271	Alternative sequence	ID=VSP_025958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MFF	Q9GZY8	251	270	199	271	Alternative sequence	ID=VSP_025958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MFF	Q9GZY8	198	250	212	212	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
MFGE8	Q08431	290	342	24	387	Chain	ID=PRO_0000007650;Note=Lactadherin
MFGE8	Q08431	129	180	24	387	Chain	ID=PRO_0000007650;Note=Lactadherin
MFGE8	Q08431	24	68	24	387	Chain	ID=PRO_0000007650;Note=Lactadherin
MFGE8	Q08431	290	342	24	387	Chain	ID=PRO_0000007650;Note=Lactadherin
MFGE8	Q08431	129	180	24	387	Chain	ID=PRO_0000007650;Note=Lactadherin
MFGE8	Q08431	24	68	24	387	Chain	ID=PRO_0000007650;Note=Lactadherin
MFGE8	Q08431	290	342	202	387	Chain	ID=PRO_0000007651;Note=Lactadherin short form
MFGE8	Q08431	290	342	202	387	Chain	ID=PRO_0000007651;Note=Lactadherin short form
MFGE8	Q08431	290	342	268	317	Chain	ID=PRO_0000007652;Note=Medin
MFGE8	Q08431	290	342	268	317	Chain	ID=PRO_0000007652;Note=Medin
MFGE8	Q08431	24	68	24	67	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MFGE8	Q08431	24	68	24	67	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MFGE8	Q08431	129	180	70	225	Domain	Note=F5/8 type C 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081
MFGE8	Q08431	129	180	70	225	Domain	Note=F5/8 type C 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081
MFGE8	Q08431	290	342	230	387	Domain	Note=F5/8 type C 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081
MFGE8	Q08431	290	342	230	387	Domain	Note=F5/8 type C 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081
MFGE8	Q08431	24	68	46	48	Motif	Note=Cell attachment site
MFGE8	Q08431	24	68	46	48	Motif	Note=Cell attachment site
MFGE8	Q08431	24	68	42	42	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
MFGE8	Q08431	24	68	42	42	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
MFGE8	Q08431	290	342	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
MFGE8	Q08431	290	342	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
MFGE8	Q08431	290	342	329	329	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
MFGE8	Q08431	290	342	329	329	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
MFGE8	Q08431	24	68	27	38	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	24	68	27	38	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	24	68	32	55	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	24	68	32	55	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	24	68	57	66	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	24	68	57	66	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	129	180	70	225	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	129	180	70	225	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	290	342	230	387	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	290	342	230	387	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MFGE8	Q08431	24	68	1	112	Alternative sequence	ID=VSP_039108;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MFGE8	Q08431	24	68	1	112	Alternative sequence	ID=VSP_039108;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MFGE8	Q08431	24	68	25	69	Alternative sequence	ID=VSP_059818;Note=In isoform 4. DICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETK->E
MFGE8	Q08431	24	68	25	69	Alternative sequence	ID=VSP_059818;Note=In isoform 4. DICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETK->E
MFGE8	Q08431	290	342	291	342	Alternative sequence	ID=VSP_039953;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
MFGE8	Q08431	290	342	291	342	Alternative sequence	ID=VSP_039953;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
MGRN1	O60291	226	242	2	552	Chain	ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1
MGRN1	O60291	242	265	2	552	Chain	ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1
MGRN1	O60291	355	377	2	552	Chain	ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1
MGRN1	O60291	355	377	356	377	Alternative sequence	ID=VSP_036462;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19737927;Dbxref=PMID:19737927
MGRN1	O60291	242	265	248	248	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
MGRN1	O60291	242	265	248	248	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAGOHB	Q96A72	51	88	2	148	Chain	ID=PRO_0000174146;Note=Protein mago nashi homolog 2
MAGOH	P61326	49	86	1	146	Chain	ID=PRO_0000174145;Note=Protein mago nashi homolog
MAGOH	P61326	49	86	50	86	Alternative sequence	ID=VSP_056246;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGOH	P61326	49	86	66	68	Mutagenesis	Note=Slightly reduced nonsense-mediated decay activity. DSE->RSR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16209946;Dbxref=PMID:16209946
MAGOH	P61326	49	86	68	68	Mutagenesis	Note=Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs%3B when associated with R-72%3B K-73 and R-117. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19410547;Dbxref=PMID:19410547
MAGOH	P61326	49	86	72	73	Mutagenesis	Note=Fully active. ED->RK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16209946;Dbxref=PMID:16209946
MAGOH	P61326	49	86	72	72	Mutagenesis	Note=Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs%3B when associated with R-68%3B K-73 and R-117. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19410547;Dbxref=PMID:19410547
MAGOH	P61326	49	86	73	73	Mutagenesis	Note=Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs%3B when associated with R-68%3B R-72 and R-117. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19410547;Dbxref=PMID:19410547
MAGOH	P61326	49	86	85	87	Mutagenesis	Note=Fully active. RQE->EQR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16209946;Dbxref=PMID:16209946
MAGOH	P61326	49	86	44	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAGOH	P61326	49	86	54	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAGOH	P61326	49	86	69	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAGOH	P61326	49	86	74	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XB2
MAGOH	P61326	49	86	85	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MICAL3	Q7RTP6	1064	1102	1	2002	Chain	ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3
MICAL3	Q7RTP6	1018	1064	1	2002	Chain	ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3
MICAL3	Q7RTP6	196	230	1	2002	Chain	ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3
MICAL3	Q7RTP6	196	230	2	494	Region	Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3
MICAL3	Q7RTP6	1064	1102	889	1138	Compositional bias	Note=Glu-rich
MICAL3	Q7RTP6	1018	1064	889	1138	Compositional bias	Note=Glu-rich
MICAL3	Q7RTP6	1064	1102	949	2002	Alternative sequence	ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802
MICAL3	Q7RTP6	1018	1064	949	2002	Alternative sequence	ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802
MICAL3	Q7RTP6	1064	1102	950	2002	Alternative sequence	ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MICAL3	Q7RTP6	1018	1064	950	2002	Alternative sequence	ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MICAL3	Q7RTP6	1064	1102	967	2002	Alternative sequence	ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
MICAL3	Q7RTP6	1018	1064	967	2002	Alternative sequence	ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
MICU2	Q8IYU8	199	221	23	434	Chain	ID=PRO_0000251217;Note=Calcium uptake protein 2%2C mitochondrial
MICU2	Q8IYU8	199	221	172	207	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MICU2	Q8IYU8	199	221	205	205	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MICU2	Q8IYU8	199	221	205	205	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLF1	P58340	65	93	1	268	Chain	ID=PRO_0000220752;Note=Myeloid leukemia factor 1
MLF1	P58340	93	136	1	268	Chain	ID=PRO_0000220752;Note=Myeloid leukemia factor 1
MLF1	P58340	65	93	50	125	Region	Note=Interaction with COPS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15861129;Dbxref=PMID:15861129
MLF1	P58340	93	136	50	125	Region	Note=Interaction with COPS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15861129;Dbxref=PMID:15861129
MLF1	P58340	65	93	65	65	Alternative sequence	ID=VSP_043726;Note=In isoform 3 and isoform 4. T->TATSCSLVPFGDFGGM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MLF1	P58340	93	136	94	136	Alternative sequence	ID=VSP_043131;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MLF2	Q15773	72	90	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	60	72	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	72	90	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	60	72	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	72	90	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	60	72	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	72	90	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	60	72	1	248	Chain	ID=PRO_0000220754;Note=Myeloid leukemia factor 2
MLF2	Q15773	72	90	80	80	Natural variant	ID=VAR_036429;Note=In a colorectal cancer sample%3B somatic mutation. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MLF2	Q15773	72	90	80	80	Natural variant	ID=VAR_036429;Note=In a colorectal cancer sample%3B somatic mutation. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MLF2	Q15773	72	90	80	80	Natural variant	ID=VAR_036429;Note=In a colorectal cancer sample%3B somatic mutation. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MLF2	Q15773	72	90	80	80	Natural variant	ID=VAR_036429;Note=In a colorectal cancer sample%3B somatic mutation. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NFYB	P25208	77	143	1	207	Chain	ID=PRO_0000204609;Note=Nuclear transcription factor Y subunit beta
NFYB	P25208	77	143	1	207	Chain	ID=PRO_0000204609;Note=Nuclear transcription factor Y subunit beta
NFYB	P25208	77	143	53	142	Region	Note=B domain
NFYB	P25208	77	143	53	142	Region	Note=B domain
NFYB	P25208	77	143	86	97	Region	Note=Subunit association domain (SAD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NFYB	P25208	77	143	86	97	Region	Note=Subunit association domain (SAD);Ontology_term=ECO:0000250;evidence=ECO:0000250
NFYB	P25208	77	143	143	207	Region	Note=C domain
NFYB	P25208	77	143	143	207	Region	Note=C domain
NFYB	P25208	77	143	140	140	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23332751;Dbxref=PMID:23332751
NFYB	P25208	77	143	140	140	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23332751;Dbxref=PMID:23332751
NFYB	P25208	77	143	80	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	80	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	111	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	111	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	115	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	115	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	128	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	128	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	131	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
NFYB	P25208	77	143	131	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CSR
SLC9A3R1	O14745	147	201	2	358	Chain	ID=PRO_0000096799;Note=Na(+)/H(+) exchange regulatory cofactor NHE-RF1
SLC9A3R1	O14745	147	201	154	234	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SLC9A3R1	O14745	147	201	162	162	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SLC9A3R1	O14745	147	201	1	156	Alternative sequence	ID=VSP_055497;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC9A3R1	O14745	147	201	153	153	Natural variant	ID=VAR_048021;Note=In NPHLOP2%3B the mutant expressed in cultured renal cells increases the generation of cAMP by PTH and inhibits phosphate transport. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18784102;Dbxref=dbSNP:rs41282065,PMID:18784102
SLC9A3R1	O14745	147	201	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q3H
SLC9A3R1	O14745	147	201	160	162	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JXO
SLC9A3R1	O14745	147	201	166	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q3H
SLC9A3R1	O14745	147	201	172	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q3H
SLC9A3R1	O14745	147	201	184	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0V
SLC9A3R1	O14745	147	201	187	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q3H
SLC9A3R1	O14745	147	201	198	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q3H
MORC1	Q86VD1	868	933	1	984	Chain	ID=PRO_0000248241;Note=MORC family CW-type zinc finger protein 1
MORC1	Q86VD1	568	589	1	984	Chain	ID=PRO_0000248241;Note=MORC family CW-type zinc finger protein 1
MORC1	Q86VD1	868	933	900	934	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MORC1	Q86VD1	568	589	569	589	Alternative sequence	ID=VSP_055495;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC16A10	Q8TF71	314	362	1	515	Chain	ID=PRO_0000314253;Note=Monocarboxylate transporter 10
SLC16A10	Q8TF71	314	362	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A10	Q8TF71	314	362	352	372	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	1	505	Chain	ID=PRO_0000211399;Note=Monocarboxylate transporter 6
SLC16A5	O15375	114	384	1	505	Chain	ID=PRO_0000211399;Note=Monocarboxylate transporter 6
SLC16A5	O15375	66	114	1	505	Chain	ID=PRO_0000211399;Note=Monocarboxylate transporter 6
SLC16A5	O15375	114	384	1	505	Chain	ID=PRO_0000211399;Note=Monocarboxylate transporter 6
SLC16A5	O15375	66	114	1	505	Chain	ID=PRO_0000211399;Note=Monocarboxylate transporter 6
SLC16A5	O15375	114	384	1	505	Chain	ID=PRO_0000211399;Note=Monocarboxylate transporter 6
SLC16A5	O15375	66	114	54	74	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	54	74	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	54	74	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	75	80	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	75	80	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	75	80	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	102	110	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	102	110	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	102	110	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	66	114	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	132	137	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	132	137	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	132	137	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	159	171	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	159	171	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	159	171	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	172	192	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	172	192	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	172	192	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	193	239	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	193	239	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	193	239	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	240	260	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	240	260	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	240	260	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	261	274	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	261	274	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	261	274	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	275	295	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	275	295	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	275	295	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	296	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	296	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	296	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	306	326	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	306	326	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	306	326	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	327	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	327	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	327	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	351	367	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	351	367	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	351	367	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	368	388	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	368	388	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A5	O15375	114	384	368	388	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAP2K2	P36507	101	150	1	400	Chain	ID=PRO_0000086372;Note=Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2	P36507	101	150	72	369	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K2	P36507	101	150	101	101	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K2	P36507	101	150	128	128	Natural variant	ID=VAR_069782;Note=In CFC4%3B results in increased kinase activity. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20358587;Dbxref=dbSNP:rs267607230,PMID:20358587
MAP2K2	P36507	101	150	134	134	Natural variant	ID=VAR_069783;Note=In CFC4. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18042262;Dbxref=dbSNP:rs121434499,PMID:18042262
MAP2K2	P36507	101	150	97	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I
MAP2K2	P36507	101	150	110	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I
MAP2K2	P36507	101	150	120	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I
MAP2K2	P36507	101	150	133	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I
MPRIP	Q6WCQ1	41	67	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	67	89	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	345	383	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	383	402	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	425	455	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	682	721	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	863	903	2	1025	Chain	ID=PRO_0000223930;Note=Myosin phosphatase Rho-interacting protein
MPRIP	Q6WCQ1	41	67	43	150	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
MPRIP	Q6WCQ1	67	89	43	150	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
MPRIP	Q6WCQ1	383	402	387	483	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
MPRIP	Q6WCQ1	425	455	387	483	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
MPRIP	Q6WCQ1	41	67	2	383	Region	Note=Interaction with F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250
MPRIP	Q6WCQ1	67	89	2	383	Region	Note=Interaction with F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250
MPRIP	Q6WCQ1	345	383	2	383	Region	Note=Interaction with F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250
MPRIP	Q6WCQ1	383	402	2	383	Region	Note=Interaction with F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250
MPRIP	Q6WCQ1	682	721	546	824	Region	Note=Interaction with RHOA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14506264;Dbxref=PMID:14506264
MPRIP	Q6WCQ1	863	903	824	879	Region	Note=Interaction with PPP1R12A
MPRIP	Q6WCQ1	682	721	673	977	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MPRIP	Q6WCQ1	863	903	673	977	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MPRIP	Q6WCQ1	345	383	348	348	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
MPRIP	Q6WCQ1	345	383	362	362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569
MPRIP	Q6WCQ1	345	383	365	365	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569
MPRIP	Q6WCQ1	863	903	891	891	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
MPRIP	Q6WCQ1	345	383	346	383	Alternative sequence	ID=VSP_051947;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MPRIP	Q6WCQ1	383	402	346	383	Alternative sequence	ID=VSP_051947;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MPRIP	Q6WCQ1	345	383	352	352	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NQO2	P16083	2	57	1	231	Chain	ID=PRO_0000071626;Note=Ribosyldihydronicotinamide dehydrogenase [quinone]
NQO2	P16083	101	139	1	231	Chain	ID=PRO_0000071626;Note=Ribosyldihydronicotinamide dehydrogenase [quinone]
NQO2	P16083	2	57	1	231	Chain	ID=PRO_0000071626;Note=Ribosyldihydronicotinamide dehydrogenase [quinone]
NQO2	P16083	101	139	1	231	Chain	ID=PRO_0000071626;Note=Ribosyldihydronicotinamide dehydrogenase [quinone]
NQO2	P16083	2	57	1	231	Chain	ID=PRO_0000071626;Note=Ribosyldihydronicotinamide dehydrogenase [quinone]
NQO2	P16083	101	139	1	231	Chain	ID=PRO_0000071626;Note=Ribosyldihydronicotinamide dehydrogenase [quinone]
NQO2	P16083	2	57	18	21	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	2	57	18	21	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	2	57	18	21	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	101	139	104	107	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	101	139	104	107	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	101	139	104	107	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	101	139	127	129	Region	Note=Substrate binding
NQO2	P16083	101	139	127	129	Region	Note=Substrate binding
NQO2	P16083	101	139	127	129	Region	Note=Substrate binding
NQO2	P16083	2	57	12	12	Binding site	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	2	57	12	12	Binding site	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	2	57	12	12	Binding site	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18254726,ECO:0000269|PubMed:19236722;Dbxref=PMID:18254726,PMID:19236722
NQO2	P16083	2	57	16	16	Natural variant	ID=VAR_021399;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs28383623
NQO2	P16083	2	57	16	16	Natural variant	ID=VAR_021399;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs28383623
NQO2	P16083	2	57	16	16	Natural variant	ID=VAR_021399;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs28383623
NQO2	P16083	2	57	29	29	Natural variant	ID=VAR_021400;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17136117
NQO2	P16083	2	57	29	29	Natural variant	ID=VAR_021400;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17136117
NQO2	P16083	2	57	29	29	Natural variant	ID=VAR_021400;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17136117
NQO2	P16083	2	57	47	47	Natural variant	ID=VAR_021401;Note=L->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1691923,ECO:0000269|PubMed:8182056,ECO:0000269|Ref.3,ECO:0000269|Ref.4,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1143684,PMID:14702039,PMID:15489334,PMID:1691923,PMID:8182056
NQO2	P16083	2	57	47	47	Natural variant	ID=VAR_021401;Note=L->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1691923,ECO:0000269|PubMed:8182056,ECO:0000269|Ref.3,ECO:0000269|Ref.4,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1143684,PMID:14702039,PMID:15489334,PMID:1691923,PMID:8182056
NQO2	P16083	2	57	47	47	Natural variant	ID=VAR_021401;Note=L->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1691923,ECO:0000269|PubMed:8182056,ECO:0000269|Ref.3,ECO:0000269|Ref.4,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1143684,PMID:14702039,PMID:15489334,PMID:1691923,PMID:8182056
NQO2	P16083	2	57	5	10	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	5	10	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	5	10	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	18	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	18	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	18	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	36	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	36	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	36	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	42	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	42	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	42	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	53	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	53	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	2	57	53	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	105	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2N
NQO2	P16083	101	139	105	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2N
NQO2	P16083	101	139	105	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2N
NQO2	P16083	101	139	111	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	111	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	111	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	123	125	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	123	125	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	123	125	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NHF
NQO2	P16083	101	139	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NHF
NQO2	P16083	101	139	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NHF
NQO2	P16083	101	139	133	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	133	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	133	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
NQO2	P16083	101	139	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FGL
MS4A5	Q9H3V2	113	164	1	200	Chain	ID=PRO_0000158637;Note=Membrane-spanning 4-domains subfamily A member 5
MS4A5	Q9H3V2	113	164	102	120	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A5	Q9H3V2	113	164	121	141	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A5	Q9H3V2	113	164	142	159	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A5	Q9H3V2	113	164	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A5	Q9H3V2	113	164	123	123	Natural variant	ID=VAR_036402;Note=In a colorectal cancer sample%3B somatic mutation. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MS4A5	Q9H3V2	113	164	163	163	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MSH3	P20585	193	264	1	1137	Chain	ID=PRO_0000115192;Note=DNA mismatch repair protein Msh3
MSH3	P20585	264	303	1	1137	Chain	ID=PRO_0000115192;Note=DNA mismatch repair protein Msh3
MSH3	P20585	773	811	1	1137	Chain	ID=PRO_0000115192;Note=DNA mismatch repair protein Msh3
MSH3	P20585	193	264	75	297	Region	Note=Interaction with EXO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11427529;Dbxref=PMID:11427529
MSH3	P20585	264	303	75	297	Region	Note=Interaction with EXO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11427529;Dbxref=PMID:11427529
MSH3	P20585	773	811	789	789	Natural variant	ID=VAR_055251;Note=Y->F;Dbxref=dbSNP:rs10067975
MSH3	P20585	193	264	231	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	193	264	241	245	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	193	264	246	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	193	264	253	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	193	264	260	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	264	303	260	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	264	303	275	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	264	303	280	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	264	303	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	264	303	290	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	773	811	769	773	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	773	811	775	781	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH3	P20585	773	811	783	814	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
SLC11A1	P49279	50	91	1	550	Chain	ID=PRO_0000212588;Note=Natural resistance-associated macrophage protein 1
SLC11A1	P49279	91	131	1	550	Chain	ID=PRO_0000212588;Note=Natural resistance-associated macrophage protein 1
SLC11A1	P49279	265	318	1	550	Chain	ID=PRO_0000212588;Note=Natural resistance-associated macrophage protein 1
SLC11A1	P49279	318	348	1	550	Chain	ID=PRO_0000212588;Note=Natural resistance-associated macrophage protein 1
SLC11A1	P49279	50	91	1	58	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	50	91	59	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	50	91	77	85	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	50	91	86	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	91	131	86	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	91	131	106	142	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	265	318	260	287	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	265	318	288	307	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	265	318	308	349	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	318	348	308	349	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	50	91	3	80	Compositional bias	Note=Pro/Ser-rich
SLC11A1	P49279	318	348	324	324	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	318	348	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC11A1	P49279	50	91	14	131	Alternative sequence	ID=VSP_047876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC11A1	P49279	91	131	14	131	Alternative sequence	ID=VSP_047876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC11A1	P49279	265	318	318	318	Natural variant	ID=VAR_004630;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7717395;Dbxref=dbSNP:rs201565523,PMID:7717395
SLC11A1	P49279	318	348	318	318	Natural variant	ID=VAR_004630;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7717395;Dbxref=dbSNP:rs201565523,PMID:7717395
SLC11A1	P49279	50	91	54	54	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC11A1	P49279	50	91	84	84	Sequence conflict	Note=A->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC11A1	P49279	50	91	86	86	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC11A1	P49279	265	318	275	275	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC11A1	P49279	265	318	305	305	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC11A1	P49279	265	318	315	315	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTHFD2	P13995	95	136	36	350	Chain	ID=PRO_0000034049;Note=Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase%2C mitochondrial
MTHFD2	P13995	187	223	36	350	Chain	ID=PRO_0000034049;Note=Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase%2C mitochondrial
MTHFD2	P13995	254	296	36	350	Chain	ID=PRO_0000034049;Note=Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase%2C mitochondrial
MTHFD2	P13995	187	223	200	202	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16100107,ECO:0000269|PubMed:27899380;Dbxref=PMID:16100107,PMID:27899380
MTHFD2	P13995	95	136	131	133	Region	Note=Substrate binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27899380;Dbxref=PMID:27899380
MTHFD2	P13995	95	136	1	102	Alternative sequence	ID=VSP_056188;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MTHFD2	P13995	187	223	201	201	Mutagenesis	Note=Complete loss of NAD and NADP-dependent dehydrogenase specific activity. R->A%2CS%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16100107;Dbxref=PMID:16100107
MTHFD2	P13995	95	136	95	95	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTHFD2	P13995	95	136	79	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	95	136	98	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	95	136	110	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	95	136	128	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	187	223	175	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	187	223	195	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	187	223	203	205	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	187	223	206	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	187	223	219	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	254	296	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	254	296	270	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	254	296	277	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	254	296	288	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTHFD2	P13995	254	296	295	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TC4
MTPN	P58546	62	90	2	118	Chain	ID=PRO_0000067031;Note=Myotrophin
MTPN	P58546	62	90	34	66	Repeat	Note=ANK 2
MTPN	P58546	62	90	67	99	Repeat	Note=ANK 3
MTPN	P58546	62	90	71	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AAA
MTPN	P58546	62	90	81	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AAA
METTL25	Q8N6Q8	177	377	1	603	Chain	ID=PRO_0000252148;Note=Methyltransferase-like protein 25
METTL25	Q8N6Q8	524	549	1	603	Chain	ID=PRO_0000252148;Note=Methyltransferase-like protein 25
METTL25	Q8N6Q8	549	573	1	603	Chain	ID=PRO_0000252148;Note=Methyltransferase-like protein 25
METTL25	Q8N6Q8	177	377	249	249	Natural variant	ID=VAR_027779;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs4296098,PMID:15489334
MICAL2	O94851	196	230	1	1124	Chain	ID=PRO_0000075844;Note=[F-actin]-monooxygenase MICAL2
MICAL2	O94851	316	402	1	1124	Chain	ID=PRO_0000075844;Note=[F-actin]-monooxygenase MICAL2
MICAL2	O94851	665	688	1	1124	Chain	ID=PRO_0000075844;Note=[F-actin]-monooxygenase MICAL2
MICAL2	O94851	738	779	1	1124	Chain	ID=PRO_0000075844;Note=[F-actin]-monooxygenase MICAL2
MICAL2	O94851	928	949	1	1124	Chain	ID=PRO_0000075844;Note=[F-actin]-monooxygenase MICAL2
MICAL2	O94851	949	985	1	1124	Chain	ID=PRO_0000075844;Note=[F-actin]-monooxygenase MICAL2
MICAL2	O94851	196	230	2	494	Region	Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3
MICAL2	O94851	316	402	2	494	Region	Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3
MICAL2	O94851	665	688	660	681	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24440334;Dbxref=PMID:24440334
MICAL2	O94851	316	402	398	398	Binding site	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3
MICAL2	O94851	738	779	739	985	Alternative sequence	ID=VSP_042593;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16675569;Dbxref=PMID:16675569
MICAL2	O94851	928	949	739	985	Alternative sequence	ID=VSP_042593;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16675569;Dbxref=PMID:16675569
MICAL2	O94851	949	985	739	985	Alternative sequence	ID=VSP_042593;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16675569;Dbxref=PMID:16675569
MICAL2	O94851	738	779	739	928	Alternative sequence	ID=VSP_042594;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16675569;Dbxref=PMID:14702039,PMID:16675569
MICAL2	O94851	928	949	739	928	Alternative sequence	ID=VSP_042594;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16675569;Dbxref=PMID:14702039,PMID:16675569
MICAL2	O94851	738	779	740	986	Alternative sequence	ID=VSP_009860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MICAL2	O94851	928	949	740	986	Alternative sequence	ID=VSP_009860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MICAL2	O94851	949	985	740	986	Alternative sequence	ID=VSP_009860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MICAL2	O94851	928	949	929	949	Alternative sequence	ID=VSP_042595;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MICAL2	O94851	949	985	929	949	Alternative sequence	ID=VSP_042595;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MICAL2	O94851	949	985	950	985	Alternative sequence	ID=VSP_042596;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16675569;Dbxref=PMID:16675569
MICAL2	O94851	196	230	220	220	Natural variant	ID=VAR_021992;Note=I->V;Dbxref=dbSNP:rs2306727
MICAL2	O94851	665	688	687	687	Natural variant	ID=VAR_050156;Note=D->E;Dbxref=dbSNP:rs3794084
MICAL2	O94851	665	688	677	681	Mutagenesis	Note=In MICAL-2NLSMut%3B abolishes nuclear localization. KRRRK->AAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24440334;Dbxref=PMID:24440334
MICAL2	O94851	196	230	208	208	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MSANTD1	Q6ZTZ1	107	198	1	278	Chain	ID=PRO_0000321819;Note=Myb/SANT-like DNA-binding domain-containing protein 1
MSANTD1	Q6ZTZ1	107	198	44	129	Domain	Note=Myb-like
MSH2	P43246	122	215	2	934	Chain	ID=PRO_0000115183;Note=DNA mismatch repair protein Msh2
MSH2	P43246	264	314	2	934	Chain	ID=PRO_0000115183;Note=DNA mismatch repair protein Msh2
MSH2	P43246	122	215	127	127	Natural variant	ID=VAR_019234;Note=In HNPCC1%3B presumed to enhance cancer risk considerably when associated with P-328%3B shows significantly decreased repair efficiency when associated with variant P-328. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12655564,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22581703,ECO:0000269|Ref.9;Dbxref=dbSNP:rs17217772,PMID:12655564,PMID:18951462,PMID:21120944,PMID:22581703
MSH2	P43246	122	215	139	139	Natural variant	ID=VAR_004472;Note=In HNPCC1. N->S
MSH2	P43246	122	215	145	145	Natural variant	ID=VAR_004473;Note=In HNPCC1%3B unknown pathological significance%3B normal mismatch repair activity. I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16451135,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22581703;Dbxref=dbSNP:rs63750124,PMID:16451135,PMID:21120944,PMID:22581703
MSH2	P43246	122	215	161	161	Natural variant	ID=VAR_012936;Note=In HNPCC1%3B decreased mismatch repair activity%3B affects protein stability%3B loss of protein expression. V->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11726306,ECO:0000269|PubMed:17101317,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63750126,PMID:11726306,PMID:17101317,PMID:18951462,PMID:21120944
MSH2	P43246	122	215	162	162	Natural variant	ID=VAR_054512;Note=In HNPCC1. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17128465;Dbxref=dbSNP:rs63750773,PMID:17128465
MSH2	P43246	122	215	162	162	Natural variant	ID=VAR_043747;Note=In HNPCC1%3B decreased mismatch repair activity%3B associated with an abnormal subcellular localization pattern%3B affects protein stability%3B loss of protein expression. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15991316,ECO:0000269|PubMed:17101317,ECO:0000269|PubMed:18781619,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63750624,PMID:15991316,PMID:17101317,PMID:18781619,PMID:18951462,PMID:21120944
MSH2	P43246	122	215	163	163	Natural variant	ID=VAR_043748;Note=In HNPCC1. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12200596;Dbxref=dbSNP:rs63750214,PMID:12200596
MSH2	P43246	122	215	163	163	Natural variant	ID=VAR_022670;Note=In HNPCC1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14635101;Dbxref=dbSNP:rs63750214,PMID:14635101
MSH2	P43246	122	215	164	164	Natural variant	ID=VAR_043749;Note=In HNPCC1%3B decreased mismatch repair activity%3B affects protein stability%3B loss of protein expression. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17101317,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63750582,PMID:17101317,PMID:18951462,PMID:21120944
MSH2	P43246	122	215	165	165	Natural variant	ID=VAR_067284;Note=In HNPCC1%3B unknown pathological significance%3B decreased mismatch repair activity. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22102614;Dbxref=dbSNP:rs587779163,PMID:22102614
MSH2	P43246	122	215	167	167	Natural variant	ID=VAR_004474;Note=In HNPCC1%3B shows reduced mismatch binding%3B does not show a decreased expression level of the MutS alpha complex%3B not associated with an abnormal subcellular localization pattern%3B normal mismatch repair activity. D->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11870161,ECO:0000269|PubMed:12124176,ECO:0000269|PubMed:18781619,ECO:0000269|PubMed:18822302,ECO:0000269|PubMed:22102614,ECO:0000269|PubMed:8872463;Dbxref=dbSNP:rs63750255,PMID:11870161,PMID:12124176,PMID:18781619,PMID:18822302,PMID:22102614,PMID:8872463
MSH2	P43246	122	215	169	169	Natural variant	ID=VAR_043750;Note=In HNPCC1 and CRC%3B unknown pathological significance. I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12792735,ECO:0000269|PubMed:15996210;Dbxref=dbSNP:rs63750716,PMID:12792735,PMID:15996210
MSH2	P43246	122	215	173	173	Natural variant	ID=VAR_043751;Note=In HNPCC1%3B decreased mismatch repair activity%3B affects protein stability%3B loss of protein expression. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17101317,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63750070,PMID:17101317,PMID:18951462,PMID:21120944
MSH2	P43246	122	215	175	175	Natural variant	ID=VAR_043752;Note=In HNPCC1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655568;Dbxref=dbSNP:rs63751291,PMID:12655568
MSH2	P43246	122	215	177	177	Natural variant	ID=VAR_067285;Note=In HNPCC1%3B requires 2 nucleotide substitutions%3B unknown pathological significance%3B normal mismatch repair activity. E->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22102614;Dbxref=PMID:22102614
MSH2	P43246	122	215	187	187	Natural variant	ID=VAR_043753;Note=In HNPCC1%3B decreased mismatch repair activity%3B affects protein stability%3B loss of protein expression. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17101317,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63751444,PMID:17101317,PMID:18951462,PMID:21120944
MSH2	P43246	122	215	187	187	Natural variant	ID=VAR_076352;Note=In HNPCC1%3B decreased mismatch repair activity%3B loss of protein expression. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120944;Dbxref=dbSNP:rs63751444,PMID:21120944
MSH2	P43246	122	215	198	198	Natural variant	ID=VAR_054513;Note=In HNPCC1. E->G;Dbxref=dbSNP:rs63750327
MSH2	P43246	122	215	199	199	Natural variant	ID=VAR_012937;Note=In glioma%3B also associated with HNPCC1%3B no effect on MSH2 splicing. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18561205,ECO:0000269|PubMed:9777949;Dbxref=dbSNP:rs63751110,PMID:18561205,PMID:9777949
MSH2	P43246	122	215	203	203	Natural variant	ID=VAR_043754;Note=In CRC%3B unknown pathological significance%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12792735;Dbxref=dbSNP:rs587779973,PMID:12792735
MSH2	P43246	122	215	205	205	Natural variant	ID=VAR_068705;Note=Shows no defects%3B normal mismatch repair activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22581703;Dbxref=dbSNP:rs63749984,PMID:22581703
MSH2	P43246	264	314	265	314	Natural variant	ID=VAR_004475;Note=In HNPCC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718327;Dbxref=PMID:9718327
MSH2	P43246	264	314	272	272	Natural variant	ID=VAR_043756;Note=In HNPCC1%3B unknown pathological significance%3B shows slightly reduced mismatch binding or release efficiency%3B results in partial MSH2 exon 5 skipping%3B normal mismatch repair activity. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17101317,ECO:0000269|PubMed:18561205,ECO:0000269|PubMed:18951462,ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:22102614;Dbxref=dbSNP:rs34136999,PMID:17101317,PMID:18561205,PMID:18951462,PMID:21120944,PMID:22102614
MSH2	P43246	264	314	283	283	Natural variant	ID=VAR_043757;Note=In HNPCC1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15870828;Dbxref=dbSNP:rs63750381,PMID:15870828
MSH2	P43246	264	314	305	305	Natural variant	ID=VAR_004476;Note=In HNPCC1%3B normal mismatch repair activity. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22102614,ECO:0000269|PubMed:9311737;Dbxref=dbSNP:rs63751454,PMID:22102614,PMID:9311737
MSH2	P43246	122	215	117	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O8B
MSH2	P43246	122	215	132	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	147	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	155	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	160	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	168	171	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	172	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	185	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	197	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	122	215	208	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	264	314	264	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	264	314	279	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	264	314	283	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	264	314	289	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	264	314	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSH2	P43246	264	314	304	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THX
MSI1	O43347	244	263	1	362	Chain	ID=PRO_0000081649;Note=RNA-binding protein Musashi homolog 1
MSI1	O43347	244	263	245	245	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
MOSPD1	Q9UJG1	149	203	1	213	Chain	ID=PRO_0000213459;Note=Motile sperm domain-containing protein 1
MOSPD1	Q9UJG1	149	203	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD1	Q9UJG1	149	203	191	211	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD1	Q9UJG1	149	203	149	150	Alternative sequence	ID=VSP_014043;Note=In isoform 3. PE->PGK;Ontology_term=ECO:0000305;evidence=ECO:0000305
MOSPD1	Q9UJG1	149	203	150	203	Alternative sequence	ID=VSP_014044;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2	P11137	151	1393	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
MAP2	P11137	1462	1507	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
MAP2	P11137	151	1393	701	744	Region	Note=Interaction with KNDC1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	1462	1507	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAP2	P11137	151	1393	285	285	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	498	498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	605	605	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	610	610	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15146
MAP2	P11137	151	1393	725	725	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	729	729	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	733	733	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	736	736	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	738	738	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	745	745	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	821	821	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	881	881	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15146
MAP2	P11137	151	1393	890	890	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15146
MAP2	P11137	151	1393	936	936	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15146
MAP2	P11137	151	1393	1133	1133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	1134	1134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	1139	1139	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	1154	1154	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15146
MAP2	P11137	151	1393	1155	1155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	1159	1159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20357
MAP2	P11137	151	1393	1347	1347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
MAP2	P11137	151	1393	1353	1353	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
MAP2	P11137	151	1393	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
MAP2	P11137	1462	1507	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
MAP2	P11137	151	1393	152	229	Alternative sequence	ID=VSP_043596;Note=In isoform 4. DLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHT->AAGGESALAPSVFKQAKDKVSNSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP2	P11137	151	1393	152	155	Alternative sequence	ID=VSP_011302;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8294038;Dbxref=PMID:8294038
MAP2	P11137	151	1393	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP2	P11137	1462	1507	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP2	P11137	151	1393	179	179	Natural variant	ID=VAR_050019;Note=E->G;Dbxref=dbSNP:rs6749066
MAP2	P11137	151	1393	277	277	Natural variant	ID=VAR_036014;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MAP2	P11137	151	1393	423	423	Natural variant	ID=VAR_019613;Note=R->K;Dbxref=dbSNP:rs741006
MAP2	P11137	151	1393	705	705	Natural variant	ID=VAR_036015;Note=In a colorectal cancer sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs146432517,PMID:16959974
MAP2	P11137	151	1393	976	976	Natural variant	ID=VAR_050020;Note=H->L;Dbxref=dbSNP:rs13425372
MAP2	P11137	151	1393	991	991	Natural variant	ID=VAR_050021;Note=G->R;Dbxref=dbSNP:rs35927101
MAP2	P11137	151	1393	1099	1099	Natural variant	ID=VAR_050022;Note=M->V;Dbxref=dbSNP:rs17745550
MAP2	P11137	151	1393	187	187	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2	P11137	151	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2	P11137	151	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP2	P11137	151	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUCL1	Q96DR8	19	33	1	20	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
MUCL1	Q96DR8	19	33	21	90	Chain	ID=PRO_0000228159;Note=Mucin-like protein 1
MUCL1	Q96DR8	19	33	23	68	Compositional bias	Note=Thr-rich
MUCL1	Q96DR8	19	33	23	23	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MUCL1	Q96DR8	19	33	24	24	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MUCL1	Q96DR8	19	33	30	30	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DENND4A	Q7Z401	1503	1551	1	1863	Chain	ID=PRO_0000223952;Note=C-myc promoter-binding protein
DENND4A	Q7Z401	810	853	1	1863	Chain	ID=PRO_0000223952;Note=C-myc promoter-binding protein
DENND4A	Q7Z401	810	853	809	843	Repeat	Note=PPR 2
DENND4A	Q7Z401	1503	1551	1508	1508	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DENND4A	Q7Z401	1503	1551	1532	1532	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO1A	Q9UBC5	735	758	1	1043	Chain	ID=PRO_0000123438;Note=Unconventional myosin-Ia
MYO1A	Q9UBC5	423	444	1	1043	Chain	ID=PRO_0000123438;Note=Unconventional myosin-Ia
MYO1A	Q9UBC5	180	213	1	1043	Chain	ID=PRO_0000123438;Note=Unconventional myosin-Ia
MYO1A	Q9UBC5	735	758	1	1043	Chain	ID=PRO_0000123438;Note=Unconventional myosin-Ia
MYO1A	Q9UBC5	423	444	1	1043	Chain	ID=PRO_0000123438;Note=Unconventional myosin-Ia
MYO1A	Q9UBC5	180	213	1	1043	Chain	ID=PRO_0000123438;Note=Unconventional myosin-Ia
MYO1A	Q9UBC5	423	444	8	694	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1A	Q9UBC5	180	213	8	694	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1A	Q9UBC5	423	444	8	694	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1A	Q9UBC5	180	213	8	694	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1A	Q9UBC5	735	758	720	742	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1A	Q9UBC5	735	758	720	742	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1A	Q9UBC5	735	758	743	772	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1A	Q9UBC5	735	758	743	772	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO1A	Q9UBC5	423	444	426	426	Natural variant	ID=VAR_050207;Note=P->L;Dbxref=dbSNP:rs4759043
MYO1A	Q9UBC5	423	444	426	426	Natural variant	ID=VAR_050207;Note=P->L;Dbxref=dbSNP:rs4759043
NACAD	O15069	1419	1468	1	1562	Chain	ID=PRO_0000280748;Note=NAC-alpha domain-containing protein 1
NACAD	O15069	1395	1419	1	1562	Chain	ID=PRO_0000280748;Note=NAC-alpha domain-containing protein 1
NACAD	O15069	1419	1468	1411	1476	Domain	Note=NAC-A/B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00507
NACAD	O15069	1395	1419	1411	1476	Domain	Note=NAC-A/B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00507
BCKDHA	P12694	96	125	46	445	Chain	ID=PRO_0000020465;Note=2-oxoisovalerate dehydrogenase subunit alpha%2C mitochondrial
BCKDHA	P12694	96	125	99	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
SLC25A21	Q9BQT8	90	110	1	299	Chain	ID=PRO_0000090644;Note=Mitochondrial 2-oxodicarboxylate carrier
SLC25A21	Q9BQT8	40	67	1	299	Chain	ID=PRO_0000090644;Note=Mitochondrial 2-oxodicarboxylate carrier
SLC25A21	Q9BQT8	90	110	11	100	Repeat	Note=Solcar 1
SLC25A21	Q9BQT8	40	67	11	100	Repeat	Note=Solcar 1
SLC25A21	Q9BQT8	90	110	107	196	Repeat	Note=Solcar 2
OGDH	Q02218	74	138	41	1023	Chain	ID=PRO_0000020432;Note=2-oxoglutarate dehydrogenase%2C mitochondrial
OGDH	Q02218	263	311	41	1023	Chain	ID=PRO_0000020432;Note=2-oxoglutarate dehydrogenase%2C mitochondrial
OGDH	Q02218	402	445	41	1023	Chain	ID=PRO_0000020432;Note=2-oxoglutarate dehydrogenase%2C mitochondrial
OGDH	Q02218	445	505	41	1023	Chain	ID=PRO_0000020432;Note=2-oxoglutarate dehydrogenase%2C mitochondrial
OGDH	Q02218	786	810	41	1023	Chain	ID=PRO_0000020432;Note=2-oxoglutarate dehydrogenase%2C mitochondrial
OGDH	Q02218	74	138	74	74	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60597
OGDH	Q02218	74	138	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60597
OGDH	Q02218	402	445	404	427	Alternative sequence	ID=VSP_043628;Note=In isoform 3. MSILLHGDAAFAGQGIVYETFHLS->RPRERRARQIVKAPCSSMEFRSPT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OGDH	Q02218	402	445	428	1023	Alternative sequence	ID=VSP_043629;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OGDH	Q02218	445	505	428	1023	Alternative sequence	ID=VSP_043629;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OGDH	Q02218	786	810	428	1023	Alternative sequence	ID=VSP_043629;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OGDH	Q02218	445	505	459	460	Mutagenesis	Note=Abolished enzyme activity and ability to promote histone succinylation. PY->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29211711;Dbxref=PMID:29211711
MYRFL	Q96LU7	327	363	1	910	Chain	ID=PRO_0000252150;Note=Myelin regulatory factor-like protein
MYRFL	Q96LU7	792	816	1	910	Chain	ID=PRO_0000252150;Note=Myelin regulatory factor-like protein
MYRFL	Q96LU7	327	363	142	405	DNA binding	Note=NDT80;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00850
CDC42BPB	Q9Y5S2	1270	1469	1	1711	Chain	ID=PRO_0000086394;Note=Serine/threonine-protein kinase MRCK beta
CDC42BPB	Q9Y5S2	996	1022	1	1711	Chain	ID=PRO_0000086394;Note=Serine/threonine-protein kinase MRCK beta
CDC42BPB	Q9Y5S2	89	117	1	1711	Chain	ID=PRO_0000086394;Note=Serine/threonine-protein kinase MRCK beta
CDC42BPB	Q9Y5S2	89	117	76	342	Domain	Note=Protein kinase;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q5VT25,ECO:0000255|PROSITE-ProRule:PRU00159
CDC42BPB	Q9Y5S2	1270	1469	1240	1513	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
CDC42BPB	Q9Y5S2	89	117	82	90	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P54265,ECO:0000255|PROSITE-ProRule:PRU00159
CDC42BPB	Q9Y5S2	89	117	105	105	Binding site	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q5VT25,ECO:0000255|PROSITE-ProRule:PRU00159
CDC42BPB	Q9Y5S2	1270	1469	1315	1315	Natural variant	ID=VAR_040838;Note=In a lung large cell carcinoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
CDC42BPB	Q9Y5S2	996	1022	1017	1017	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC42BPB	Q9Y5S2	89	117	86	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OTE
CDC42BPB	Q9Y5S2	89	117	101	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OTE
CDC42BPB	Q9Y5S2	89	117	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OTE
CDC42BPB	Q9Y5S2	89	117	115	118	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OTE
OIP5	O43482	130	170	1	229	Chain	ID=PRO_0000058038;Note=Protein Mis18-beta
OIP5	O43482	130	170	75	174	Domain	Note=Mis18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01129
OIP5	O43482	130	170	137	137	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01129
OIP5	O43482	130	170	140	140	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01129
MSL3	Q8N5Y2	62	93	1	521	Chain	ID=PRO_0000080247;Note=Male-specific lethal 3 homolog
MSL3	Q8N5Y2	62	93	32	90	Domain	Note=Chromo
MSL3	Q8N5Y2	62	93	1	166	Alternative sequence	ID=VSP_045652;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MSL3	Q8N5Y2	62	93	7	155	Alternative sequence	ID=VSP_055377;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MSL3	Q8N5Y2	62	93	65	65	Mutagenesis	Note=Diminishes DNA-binding%3B when associated with A-55. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20657587;Dbxref=PMID:20657587
MSL3	Q8N5Y2	62	93	61	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OA6
MSL3	Q8N5Y2	62	93	65	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OA6
MSL3	Q8N5Y2	62	93	69	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OA6
MSL3	Q8N5Y2	62	93	72	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OA6
MSL3	Q8N5Y2	62	93	77	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OA6
MS4A3	Q96HJ5	52	98	1	214	Chain	ID=PRO_0000158632;Note=Membrane-spanning 4-domains subfamily A member 3
MS4A3	Q96HJ5	52	98	50	70	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A3	Q96HJ5	52	98	71	81	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A3	Q96HJ5	52	98	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A3	Q96HJ5	52	98	82	87	Compositional bias	Note=Poly-Phe
MS4A3	Q96HJ5	52	98	1	123	Alternative sequence	ID=VSP_045798;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MS4A3	Q96HJ5	52	98	53	98	Alternative sequence	ID=VSP_007109;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MS4A7	Q9GZW8	49	94	1	240	Chain	ID=PRO_0000158643;Note=Membrane-spanning 4-domains subfamily A member 7
MS4A7	Q9GZW8	49	94	48	68	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A7	Q9GZW8	49	94	69	83	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A7	Q9GZW8	49	94	84	104	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A7	Q9GZW8	49	94	50	94	Alternative sequence	ID=VSP_042009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MSI2	Q96DH6	104	135	1	328	Chain	ID=PRO_0000081652;Note=RNA-binding protein Musashi homolog 2
MSI2	Q96DH6	217	242	1	328	Chain	ID=PRO_0000081652;Note=RNA-binding protein Musashi homolog 2
MSI2	Q96DH6	242	263	1	328	Chain	ID=PRO_0000081652;Note=RNA-binding protein Musashi homolog 2
MSI2	Q96DH6	104	135	21	111	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
MSI2	Q96DH6	104	135	110	187	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
MSI2	Q96DH6	242	263	253	260	Compositional bias	Note=Poly-Ala
MSI2	Q96DH6	217	242	217	218	Site	Note=Breakpoint for translocation to form MSI2/HOXA9 fusion protein
MSI2	Q96DH6	217	242	228	228	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
MSI2	Q96DH6	242	263	261	261	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
MSI2	Q96DH6	104	135	1	104	Alternative sequence	ID=VSP_011169;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MSI2	Q96DH6	242	263	243	255	Alternative sequence	ID=VSP_011170;Note=In isoform 2 and isoform 3. GFPAAAYGPVAAA->DYLPVSQDIIFIN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MSI2	Q96DH6	242	263	256	328	Alternative sequence	ID=VSP_011171;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MOSPD3	O75425	170	225	1	235	Chain	ID=PRO_0000213465;Note=Motile sperm domain-containing protein 3
MOSPD3	O75425	170	225	1	235	Chain	ID=PRO_0000213465;Note=Motile sperm domain-containing protein 3
MOSPD3	O75425	170	225	1	235	Chain	ID=PRO_0000213465;Note=Motile sperm domain-containing protein 3
MOSPD3	O75425	170	225	180	200	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD3	O75425	170	225	180	200	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD3	O75425	170	225	180	200	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD3	O75425	170	225	213	233	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD3	O75425	170	225	213	233	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MOSPD3	O75425	170	225	213	233	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MTM1	Q13496	77	114	1	603	Chain	ID=PRO_0000094930;Note=Myotubularin
MTM1	Q13496	114	148	1	603	Chain	ID=PRO_0000094930;Note=Myotubularin
MTM1	Q13496	226	289	1	603	Chain	ID=PRO_0000094930;Note=Myotubularin
MTM1	Q13496	77	114	29	97	Domain	Note=GRAM
MTM1	Q13496	226	289	163	538	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTM1	Q13496	77	114	78	114	Alternative sequence	ID=VSP_056208;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTM1	Q13496	114	148	78	114	Alternative sequence	ID=VSP_056208;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTM1	Q13496	77	114	87	87	Natural variant	ID=VAR_006389;Note=In CNMX%3B mild%3B reduced binding to PI(3%2C5)P2. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14722070,ECO:0000269|PubMed:9305655;Dbxref=dbSNP:rs587783816,PMID:14722070,PMID:9305655
MTM1	Q13496	226	289	226	226	Natural variant	ID=VAR_018238;Note=In CNMX. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12522554;Dbxref=dbSNP:rs587783848,PMID:12522554
MTM1	Q13496	226	289	227	227	Natural variant	ID=VAR_018239;Note=In CNMX. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11793470;Dbxref=dbSNP:rs587783850,PMID:11793470
MTM1	Q13496	226	289	228	228	Natural variant	ID=VAR_018240;Note=In CNMX. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11793470;Dbxref=dbSNP:rs587783851,PMID:11793470
MTM1	Q13496	226	289	229	229	Natural variant	ID=VAR_006394;Note=In CNMX%3B mild. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9305655;Dbxref=PMID:9305655
MTM1	Q13496	226	289	230	230	Natural variant	ID=VAR_018241;Note=In CNMX. W->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10063835,ECO:0000269|PubMed:12522554;Dbxref=PMID:10063835,PMID:12522554
MTM1	Q13496	226	289	232	232	Natural variant	ID=VAR_018242;Note=In CNMX. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10063835;Dbxref=PMID:10063835
MTM1	Q13496	226	289	241	241	Natural variant	ID=VAR_006395;Note=In CNMX%3B mild to moderate%3B abolishes interaction with DES. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10063835,ECO:0000269|PubMed:10502779,ECO:0000269|PubMed:11793470,ECO:0000269|PubMed:12522554,ECO:0000269|PubMed:21135508,ECO:0000269|PubMed:9305655;Dbxref=dbSNP:rs132630305,PMID:10063835,PMID:10502779,PMID:11793470,PMID:12522554,PMID:21135508,PMID:9305655
MTM1	Q13496	226	289	241	241	Natural variant	ID=VAR_006396;Note=In CNMX%3B severe%3B loss of activity. R->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10900271,ECO:0000269|PubMed:12646134,ECO:0000269|PubMed:9285787;Dbxref=PMID:10900271,PMID:12646134,PMID:9285787
MTM1	Q13496	226	289	264	264	Natural variant	ID=VAR_009219;Note=In CNMX%3B severe. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10502779;Dbxref=dbSNP:rs587783856,PMID:10502779
MTM1	Q13496	226	289	279	279	Natural variant	ID=VAR_018243;Note=In CNMX. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11793470;Dbxref=PMID:11793470
MTM1	Q13496	77	114	114	114	Mutagenesis	Note=Reduced response to PI5P. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12646134;Dbxref=PMID:12646134
MTM1	Q13496	114	148	114	114	Mutagenesis	Note=Reduced response to PI5P. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12646134;Dbxref=PMID:12646134
MTM1	Q13496	226	289	255	255	Mutagenesis	Note=Disrupts interaction with DES. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21135508;Dbxref=PMID:21135508
MTM1	Q13496	226	289	257	257	Mutagenesis	Note=No effect on subcellular location. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12118066;Dbxref=PMID:12118066
MTM1	Q13496	226	289	269	269	Mutagenesis	Note=Disrupts interaction with DES. Does not affect lipid phosphatase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21135508;Dbxref=PMID:21135508
MTM1	Q13496	226	289	278	278	Mutagenesis	Note=Localizes to plasma membrane extensions. Does not affect interaction with DES. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11001925,ECO:0000269|PubMed:12118066,ECO:0000269|PubMed:21135508;Dbxref=PMID:11001925,PMID:12118066,PMID:21135508
MTMR1	Q13613	352	414	1	665	Chain	ID=PRO_0000094932;Note=Myotubularin-related protein 1
MTMR1	Q13613	514	552	1	665	Chain	ID=PRO_0000094932;Note=Myotubularin-related protein 1
MTMR1	Q13613	552	611	1	665	Chain	ID=PRO_0000094932;Note=Myotubularin-related protein 1
MTMR1	Q13613	352	414	226	601	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR1	Q13613	514	552	226	601	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR1	Q13613	552	611	226	601	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR1	Q13613	352	414	351	354	Region	Note=Substrate binding;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27018598;Dbxref=PMID:27018598
MTMR1	Q13613	352	414	376	377	Region	Note=Substrate binding;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27018598;Dbxref=PMID:27018598
MTMR1	Q13613	552	611	608	665	Region	Note=Required for dimerization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27018598;Dbxref=PMID:27018598
MTMR1	Q13613	552	611	553	568	Alternative sequence	ID=VSP_005169;Note=In isoform 1A. DVYTKTISLWSYINSQ->AWGAGTQRARGSLRSR;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTMR1	Q13613	552	611	569	665	Alternative sequence	ID=VSP_005170;Note=In isoform 1A. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTMR1	Q13613	514	552	541	541	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTMR1	Q13613	352	414	345	353	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	352	414	361	363	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	352	414	367	374	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	352	414	377	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	352	414	397	399	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	352	414	400	407	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	352	414	409	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	514	552	500	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	514	552	516	518	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	514	552	523	535	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	514	552	543	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	514	552	546	551	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	552	611	554	557	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	552	611	561	567	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	552	611	568	572	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	552	611	591	593	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	552	611	598	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR1	Q13613	552	611	602	604	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C16
MTMR2	Q13614	462	493	1	643	Chain	ID=PRO_0000094934;Note=Myotubularin-related protein 2
MTMR2	Q13614	462	493	205	580	Domain	Note=Myotubularin phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00669
MTMR2	Q13614	462	493	463	463	Binding site	Note=Substrate
MTMR2	Q13614	462	493	460	464	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSQ
MTMR2	Q13614	462	493	465	467	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSQ
MTMR2	Q13614	462	493	479	493	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZSQ
EMCN	Q9ULC0	169	189	19	261	Chain	ID=PRO_0000019290;Note=Endomucin
EMCN	Q9ULC0	138	169	19	261	Chain	ID=PRO_0000019290;Note=Endomucin
EMCN	Q9ULC0	125	138	19	261	Chain	ID=PRO_0000019290;Note=Endomucin
EMCN	Q9ULC0	62	86	19	261	Chain	ID=PRO_0000019290;Note=Endomucin
EMCN	Q9ULC0	169	189	19	190	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMCN	Q9ULC0	138	169	19	190	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMCN	Q9ULC0	125	138	19	190	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMCN	Q9ULC0	62	86	19	190	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMCN	Q9ULC0	125	138	34	135	Compositional bias	Note=Thr-rich
EMCN	Q9ULC0	62	86	34	135	Compositional bias	Note=Thr-rich
EMCN	Q9ULC0	138	169	164	164	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMCN	Q9ULC0	169	189	178	178	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMCN	Q9ULC0	138	169	126	139	Alternative sequence	ID=VSP_043264;Note=In isoform 3. TETQSSIKTTEIPG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EMCN	Q9ULC0	125	138	126	139	Alternative sequence	ID=VSP_043264;Note=In isoform 3. TETQSSIKTTEIPG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EMCN	Q9ULC0	169	189	140	222	Alternative sequence	ID=VSP_010826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
EMCN	Q9ULC0	138	169	140	222	Alternative sequence	ID=VSP_010826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
EMCN	Q9ULC0	169	189	172	172	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC12	Q9UKN1	5128	5162	17	5478	Chain	ID=PRO_0000331620;Note=Mucin-12
MUC12	Q9UKN1	5128	5162	17	5380	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MUC12	Q9UKN1	5128	5162	5116	5154	Domain	Note=EGF-like
MUC12	Q9UKN1	5128	5162	5144	5153	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NHLRC3	Q5JS37	128	195	26	347	Chain	ID=PRO_0000317194;Note=NHL repeat-containing protein 3
NHLRC3	Q5JS37	128	195	150	196	Repeat	Note=NHL 2
NHLRC3	Q5JS37	128	195	129	195	Alternative sequence	ID=VSP_042858;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MSN	P26038	4	32	2	577	Chain	ID=PRO_0000219416;Note=Moesin
MSN	P26038	32	64	2	577	Chain	ID=PRO_0000219416;Note=Moesin
MSN	P26038	417	448	2	577	Chain	ID=PRO_0000219416;Note=Moesin
MSN	P26038	4	32	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MSN	P26038	32	64	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MSN	P26038	4	32	5	11	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	4	32	14	20	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	4	32	26	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	32	64	26	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	32	64	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	32	64	45	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	32	64	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MSN	P26038	32	64	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1
MORC3	Q14149	368	402	1	939	Chain	ID=PRO_0000096538;Note=MORC family CW-type zinc finger protein 3
MUTYH	Q9UIF7	438	489	1	546	Chain	ID=PRO_0000102239;Note=Adenine DNA glycosylase
MUTYH	Q9UIF7	329	392	1	546	Chain	ID=PRO_0000102239;Note=Adenine DNA glycosylase
MUTYH	Q9UIF7	189	227	1	546	Chain	ID=PRO_0000102239;Note=Adenine DNA glycosylase
MUTYH	Q9UIF7	151	165	1	546	Chain	ID=PRO_0000102239;Note=Adenine DNA glycosylase
MUTYH	Q9UIF7	438	489	364	495	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
MUTYH	Q9UIF7	329	392	364	495	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
MUTYH	Q9UIF7	151	165	154	154	Natural variant	ID=VAR_077646;Note=In FAP2%3B decreased function in DNA repair. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16557584,ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs777184451,PMID:16557584,PMID:25820570
MUTYH	Q9UIF7	189	227	213	213	Natural variant	ID=VAR_077650;Note=In FAP2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18515411;Dbxref=dbSNP:rs768553551,PMID:18515411
MUTYH	Q9UIF7	189	227	220	220	Natural variant	ID=VAR_077651;Note=In FAP2%3B also found in multiple polyposis case%3B unknown pathological significance%3B reduced DNA glycosylase activity%3B no effect on function in DNA repair. I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16287072,ECO:0000269|PubMed:20848659,ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs200872702,PMID:16287072,PMID:20848659,PMID:25820570
MUTYH	Q9UIF7	189	227	224	224	Natural variant	ID=VAR_077652;Note=Functional polymorphism%3B decreased function in DNA repair. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs11545695,PMID:25820570
MUTYH	Q9UIF7	329	392	335	335	Natural variant	ID=VAR_018874;Note=Polymorphism%3B does not affect function in DNA repair. Q->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12606733,ECO:0000269|PubMed:16134147,ECO:0000269|PubMed:16287072,ECO:0000269|PubMed:16941501,ECO:0000269|PubMed:25820570,ECO:0000269|Ref.4;Dbxref=dbSNP:rs3219489,PMID:12606733,PMID:16134147,PMID:16287072,PMID:16941501,PMID:25820570
MUTYH	Q9UIF7	329	392	335	335	Natural variant	ID=VAR_077666;Note=Found in a family with non-polyposis colorectal cancer-like syndrome%3B unknown pathological significance%3B does not affect function in DNA repair. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs199742231,PMID:25820570
MUTYH	Q9UIF7	329	392	370	370	Natural variant	ID=VAR_048262;Note=Polymorphism%3B does not affect DNA glycosylase activity. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20848659;Dbxref=dbSNP:rs35352891,PMID:20848659
MUTYH	Q9UIF7	329	392	377	377	Natural variant	ID=VAR_077667;Note=In FAP2%3B decreased function in DNA repair. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25820570;Dbxref=PMID:25820570
MUTYH	Q9UIF7	329	392	385	385	Natural variant	ID=VAR_077668;Note=In FAP2%3B also found in multiple polyposis cases%3B loss of DNA glycosylase activity%3B loss of function in DNA repair. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16134147,ECO:0000269|PubMed:16941501,ECO:0000269|PubMed:20848659,ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs1060501335,PMID:16134147,PMID:16941501,PMID:20848659,PMID:25820570
MUTYH	Q9UIF7	438	489	470	470	Natural variant	ID=VAR_077674;Note=In FAP2%3B loss of function in DNA repair. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs200844166,PMID:25820570
MUTYH	Q9UIF7	438	489	470	470	Natural variant	ID=VAR_077675;Note=Found in patient with multiple polyposis%3B unknown pathological significance%3B does not affect function in DNA repair. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs192816572,PMID:25820570
MUTYH	Q9UIF7	438	489	474	474	Natural variant	ID=VAR_077676;Note=In FAP2%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18515411;Dbxref=dbSNP:rs767747402,PMID:18515411
MUTYH	Q9UIF7	438	489	477	477	Natural variant	ID=VAR_064941;Note=In FAP2%3B also found in a case of sporadic colorectal cancer%3B loss of DNA glycosylase activity%3B loss of DNA binding%3B loss of function in DNA repair. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16134147,ECO:0000269|PubMed:16557584,ECO:0000269|PubMed:19953527,ECO:0000269|PubMed:20418187,ECO:0000269|PubMed:20848659,ECO:0000269|PubMed:25820570;Dbxref=PMID:16134147,PMID:16557584,PMID:19953527,PMID:20418187,PMID:20848659,PMID:25820570
MUTYH	Q9UIF7	438	489	486	486	Natural variant	ID=VAR_077677;Note=In FAP2%3B decreased function in DNA repair. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25820570;Dbxref=dbSNP:rs587782263,PMID:25820570
MUTYH	Q9UIF7	151	165	139	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	151	165	156	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	151	165	164	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	189	227	177	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	189	227	202	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	189	227	214	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	329	392	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N5N
MUTYH	Q9UIF7	329	392	358	360	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MUTYH	Q9UIF7	329	392	366	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MUTYH	Q9UIF7	329	392	379	388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MUTYH	Q9UIF7	438	489	447	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MUTYH	Q9UIF7	438	489	470	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MUTYH	Q9UIF7	438	489	475	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MUTYH	Q9UIF7	438	489	485	495	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X51
MVP	Q14764	224	303	2	893	Chain	ID=PRO_0000158980;Note=Major vault protein
MVP	Q14764	479	544	2	893	Chain	ID=PRO_0000158980;Note=Major vault protein
MVP	Q14764	545	673	2	893	Chain	ID=PRO_0000158980;Note=Major vault protein
MVP	Q14764	224	303	2	893	Chain	ID=PRO_0000158980;Note=Major vault protein
MVP	Q14764	479	544	2	893	Chain	ID=PRO_0000158980;Note=Major vault protein
MVP	Q14764	545	673	2	893	Chain	ID=PRO_0000158980;Note=Major vault protein
MVP	Q14764	224	303	218	272	Repeat	Note=MVP 5
MVP	Q14764	224	303	218	272	Repeat	Note=MVP 5
MVP	Q14764	224	303	273	323	Repeat	Note=MVP 6
MVP	Q14764	224	303	273	323	Repeat	Note=MVP 6
MVP	Q14764	479	544	458	520	Repeat	Note=MVP 9
MVP	Q14764	479	544	458	520	Repeat	Note=MVP 9
MVP	Q14764	545	673	635	635	Natural variant	ID=VAR_050179;Note=V->I;Dbxref=dbSNP:rs35916172
MVP	Q14764	545	673	635	635	Natural variant	ID=VAR_050179;Note=V->I;Dbxref=dbSNP:rs35916172
MVP	Q14764	545	673	651	651	Natural variant	ID=VAR_050180;Note=R->Q;Dbxref=dbSNP:rs3764944
MVP	Q14764	545	673	651	651	Natural variant	ID=VAR_050180;Note=R->Q;Dbxref=dbSNP:rs3764944
MYL4	P12829	162	188	2	197	Chain	ID=PRO_0000198699;Note=Myosin light chain 4
MYL4	P12829	162	188	2	197	Chain	ID=PRO_0000198699;Note=Myosin light chain 4
MYL4	P12829	162	188	2	197	Chain	ID=PRO_0000198699;Note=Myosin light chain 4
MYL4	P12829	162	188	130	165	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL4	P12829	162	188	130	165	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL4	P12829	162	188	130	165	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL4	P12829	162	188	186	186	Natural variant	ID=VAR_050458;Note=N->Y;Dbxref=dbSNP:rs16941677
MYL4	P12829	162	188	186	186	Natural variant	ID=VAR_050458;Note=N->Y;Dbxref=dbSNP:rs16941677
MYL4	P12829	162	188	186	186	Natural variant	ID=VAR_050458;Note=N->Y;Dbxref=dbSNP:rs16941677
MYL4	P12829	162	188	181	181	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL4	P12829	162	188	181	181	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL4	P12829	162	188	181	181	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL4	P12829	162	188	185	185	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL4	P12829	162	188	185	185	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYL4	P12829	162	188	185	185	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MYO1C	O00159	674	711	1	1063	Chain	ID=PRO_0000123445;Note=Unconventional myosin-Ic
MYO1C	O00159	572	599	1	1063	Chain	ID=PRO_0000123445;Note=Unconventional myosin-Ic
MYO1C	O00159	269	302	1	1063	Chain	ID=PRO_0000123445;Note=Unconventional myosin-Ic
MYO1C	O00159	674	711	47	731	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1C	O00159	572	599	47	731	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1C	O00159	269	302	47	731	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO1C	O00159	269	302	269	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	269	302	280	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	269	302	298	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	572	599	568	575	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	572	599	580	585	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	674	711	668	675	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	674	711	676	678	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	674	711	682	684	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	674	711	690	701	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO1C	O00159	674	711	707	710	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BYF
MYO10	Q9HD67	616	643	1	2058	Chain	ID=PRO_0000123473;Note=Unconventional myosin-X
MYO10	Q9HD67	529	552	1	2058	Chain	ID=PRO_0000123473;Note=Unconventional myosin-X
MYO10	Q9HD67	156	200	1	2058	Chain	ID=PRO_0000123473;Note=Unconventional myosin-X
MYO10	Q9HD67	40	93	1	2058	Chain	ID=PRO_0000123473;Note=Unconventional myosin-X
MYO10	Q9HD67	616	643	63	739	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO10	Q9HD67	529	552	63	739	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO10	Q9HD67	156	200	63	739	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO10	Q9HD67	40	93	63	739	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO10	Q9HD67	156	200	157	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO10	Q9HD67	616	643	619	641	Region	Note=Actin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO10	Q9HD67	616	643	1	643	Alternative sequence	ID=VSP_054975;Note=In isoform Headless. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
MYO10	Q9HD67	529	552	1	643	Alternative sequence	ID=VSP_054975;Note=In isoform Headless. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
MYO10	Q9HD67	156	200	1	643	Alternative sequence	ID=VSP_054975;Note=In isoform Headless. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
MYO10	Q9HD67	40	93	1	643	Alternative sequence	ID=VSP_054975;Note=In isoform Headless. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
MYO10	Q9HD67	616	643	98	2058	Alternative sequence	ID=VSP_054977;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO10	Q9HD67	529	552	98	2058	Alternative sequence	ID=VSP_054977;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO10	Q9HD67	156	200	98	2058	Alternative sequence	ID=VSP_054977;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO10	Q9HD67	40	93	41	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	40	93	46	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	40	93	51	53	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	40	93	54	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	40	93	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	40	93	76	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	40	93	93	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	156	200	151	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	156	200	163	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	156	200	186	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	156	200	193	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	529	552	543	548	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	529	552	551	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	616	643	611	627	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO10	Q9HD67	616	643	629	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I0H
MYO5B	Q9ULV0	1315	1340	1	1848	Chain	ID=PRO_0000123460;Note=Unconventional myosin-Vb
MYO5B	Q9ULV0	1201	1281	1	1848	Chain	ID=PRO_0000123460;Note=Unconventional myosin-Vb
MYO5B	Q9ULV0	668	696	1	1848	Chain	ID=PRO_0000123460;Note=Unconventional myosin-Vb
MYO5B	Q9ULV0	279	315	1	1848	Chain	ID=PRO_0000123460;Note=Unconventional myosin-Vb
MYO5B	Q9ULV0	204	252	1	1848	Chain	ID=PRO_0000123460;Note=Unconventional myosin-Vb
MYO5B	Q9ULV0	668	696	69	761	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO5B	Q9ULV0	279	315	69	761	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO5B	Q9ULV0	204	252	69	761	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO5B	Q9ULV0	1201	1281	899	1266	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO5B	Q9ULV0	1315	1340	1	1430	Alternative sequence	ID=VSP_056198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5B	Q9ULV0	1201	1281	1	1430	Alternative sequence	ID=VSP_056198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5B	Q9ULV0	668	696	1	1430	Alternative sequence	ID=VSP_056198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5B	Q9ULV0	279	315	1	1430	Alternative sequence	ID=VSP_056198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5B	Q9ULV0	204	252	1	1430	Alternative sequence	ID=VSP_056198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO5B	Q9ULV0	668	696	1	859	Alternative sequence	ID=VSP_056199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MYO5B	Q9ULV0	279	315	1	859	Alternative sequence	ID=VSP_056199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MYO5B	Q9ULV0	204	252	1	859	Alternative sequence	ID=VSP_056199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MYO5B	Q9ULV0	1315	1340	1315	1340	Alternative sequence	ID=VSP_056200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MYO5B	Q9ULV0	204	252	219	219	Natural variant	ID=VAR_054994;Note=In DIAR2. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18724368;Dbxref=dbSNP:rs1053713532,PMID:18724368
MYO5B	Q9ULV0	279	315	307	307	Natural variant	ID=VAR_056183;Note=K->N;Dbxref=dbSNP:rs17659179
OCEL1	Q9H607	206	224	1	264	Chain	ID=PRO_0000271531;Note=Occludin/ELL domain-containing protein 1
NAAA	Q02083	69	123	29	359	Chain	ID=PRO_0000002318;Note=N-acylethanolamine-hydrolyzing acid amidase
NAAA	Q02083	69	123	29	125	Chain	ID=PRO_0000419650;Note=N-acylethanolamine-hydrolyzing acid amidase subunit alpha
NAAA	Q02083	69	123	107	107	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22040171;Dbxref=PMID:22040171
NAAA	Q02083	69	123	107	107	Natural variant	ID=VAR_048336;Note=N->K;Dbxref=dbSNP:rs34751328
NAA35	Q5VZE5	91	116	1	725	Chain	ID=PRO_0000308614;Note=N-alpha-acetyltransferase 35%2C NatC auxiliary subunit
NAA35	Q5VZE5	116	172	1	725	Chain	ID=PRO_0000308614;Note=N-alpha-acetyltransferase 35%2C NatC auxiliary subunit
NAA35	Q5VZE5	209	226	1	725	Chain	ID=PRO_0000308614;Note=N-alpha-acetyltransferase 35%2C NatC auxiliary subunit
NAA35	Q5VZE5	352	372	1	725	Chain	ID=PRO_0000308614;Note=N-alpha-acetyltransferase 35%2C NatC auxiliary subunit
NAA35	Q5VZE5	430	463	1	725	Chain	ID=PRO_0000308614;Note=N-alpha-acetyltransferase 35%2C NatC auxiliary subunit
NAA35	Q5VZE5	352	372	295	725	Alternative sequence	ID=VSP_056099;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAA35	Q5VZE5	430	463	295	725	Alternative sequence	ID=VSP_056099;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BCKDHB	P21953	317	346	51	392	Chain	ID=PRO_0000020470;Note=2-oxoisovalerate dehydrogenase subunit beta%2C mitochondrial
BCKDHB	P21953	317	346	51	392	Chain	ID=PRO_0000020470;Note=2-oxoisovalerate dehydrogenase subunit beta%2C mitochondrial
BCKDHB	P21953	317	346	219	392	Alternative sequence	ID=VSP_056371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BCKDHB	P21953	317	346	219	392	Alternative sequence	ID=VSP_056371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BCKDHB	P21953	317	346	346	346	Natural variant	ID=VAR_068349;Note=In MSUD1B. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22326532;Dbxref=PMID:22326532
BCKDHB	P21953	317	346	346	346	Natural variant	ID=VAR_068349;Note=In MSUD1B. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22326532;Dbxref=PMID:22326532
BCKDHB	P21953	317	346	322	322	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCKDHB	P21953	317	346	322	322	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCKDHB	P21953	317	346	312	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
BCKDHB	P21953	317	346	312	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
BCKDHB	P21953	317	346	325	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
BCKDHB	P21953	317	346	325	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
BCKDHB	P21953	317	346	337	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
BCKDHB	P21953	317	346	337	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BFD
ODF2L	Q9ULJ1	453	506	1	636	Chain	ID=PRO_0000308909;Note=Protein BCAP
ODF2L	Q9ULJ1	352	381	1	636	Chain	ID=PRO_0000308909;Note=Protein BCAP
ODF2L	Q9ULJ1	169	208	1	636	Chain	ID=PRO_0000308909;Note=Protein BCAP
ODF2L	Q9ULJ1	453	506	1	636	Chain	ID=PRO_0000308909;Note=Protein BCAP
ODF2L	Q9ULJ1	352	381	1	636	Chain	ID=PRO_0000308909;Note=Protein BCAP
ODF2L	Q9ULJ1	169	208	1	636	Chain	ID=PRO_0000308909;Note=Protein BCAP
ODF2L	Q9ULJ1	169	208	141	220	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ODF2L	Q9ULJ1	169	208	141	220	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ODF2L	Q9ULJ1	453	506	377	484	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ODF2L	Q9ULJ1	352	381	377	484	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ODF2L	Q9ULJ1	453	506	377	484	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ODF2L	Q9ULJ1	352	381	377	484	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ODF2L	Q9ULJ1	352	381	353	381	Alternative sequence	ID=VSP_029057;Note=In isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
ODF2L	Q9ULJ1	352	381	353	381	Alternative sequence	ID=VSP_029057;Note=In isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
ODF2L	Q9ULJ1	453	506	454	506	Alternative sequence	ID=VSP_029058;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ODF2L	Q9ULJ1	453	506	454	506	Alternative sequence	ID=VSP_029058;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ODF2L	Q9ULJ1	453	506	506	506	Alternative sequence	ID=VSP_029059;Note=In isoform 3. Q->QILKQWEEYSVLAW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODF2L	Q9ULJ1	453	506	506	506	Alternative sequence	ID=VSP_029059;Note=In isoform 3. Q->QILKQWEEYSVLAW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODF2L	Q9ULJ1	169	208	177	177	Natural variant	ID=VAR_036882;Note=R->H;Dbxref=dbSNP:rs12032435
ODF2L	Q9ULJ1	169	208	177	177	Natural variant	ID=VAR_036882;Note=R->H;Dbxref=dbSNP:rs12032435
ODF2L	Q9ULJ1	169	208	203	203	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ODF2L	Q9ULJ1	169	208	203	203	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ODF3B	A8MYP8	180	227	1	253	Chain	ID=PRO_0000346440;Note=Outer dense fiber protein 3B
ODF3B	A8MYP8	36	104	1	253	Chain	ID=PRO_0000346440;Note=Outer dense fiber protein 3B
ODF3B	A8MYP8	180	227	1	253	Chain	ID=PRO_0000346440;Note=Outer dense fiber protein 3B
ODF3B	A8MYP8	36	104	1	253	Chain	ID=PRO_0000346440;Note=Outer dense fiber protein 3B
ODF3B	A8MYP8	180	227	182	207	Repeat	Note=STPGR
ODF3B	A8MYP8	180	227	182	207	Repeat	Note=STPGR
ODF3B	A8MYP8	36	104	1	36	Alternative sequence	ID=VSP_034995;Note=In isoform 2. MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNT->MGLGAGPGQTLTRMLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODF3B	A8MYP8	36	104	1	36	Alternative sequence	ID=VSP_034995;Note=In isoform 2. MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNT->MGLGAGPGQTLTRMLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODF3B	A8MYP8	180	227	130	253	Alternative sequence	ID=VSP_034997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODF3B	A8MYP8	180	227	130	253	Alternative sequence	ID=VSP_034997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NAGK	Q9UJ70	118	155	2	344	Chain	ID=PRO_0000096696;Note=N-acetyl-D-glucosamine kinase
NAGK	Q9UJ70	118	155	129	130	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2CH5,ECO:0000269|PubMed:17010375;Dbxref=PMID:17010375
NAGK	Q9UJ70	118	155	145	147	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2CH5,ECO:0000269|PubMed:17010375;Dbxref=PMID:17010375
NAGK	Q9UJ70	118	155	127	127	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:2CH6,ECO:0000305|PubMed:17010375;Dbxref=PMID:17010375
NAGK	Q9UJ70	118	155	152	152	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2CH5,ECO:0000269|PubMed:17010375;Dbxref=PMID:17010375
NAGK	Q9UJ70	118	155	121	121	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAGK	Q9UJ70	118	155	120	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH5
NAGK	Q9UJ70	118	155	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH6
NAGK	Q9UJ70	118	155	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH5
NAGK	Q9UJ70	118	155	148	150	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CH5
NAGPA	Q9UK23	391	425	50	515	Chain	ID=PRO_0000021788;Note=N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAGPA	Q9UK23	375	391	50	515	Chain	ID=PRO_0000021788;Note=N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAGPA	Q9UK23	264	306	50	515	Chain	ID=PRO_0000021788;Note=N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAGPA	Q9UK23	391	425	50	448	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGPA	Q9UK23	375	391	50	448	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGPA	Q9UK23	264	306	50	448	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGPA	Q9UK23	375	391	358	390	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NAGPA	Q9UK23	264	306	296	296	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGPA	Q9UK23	375	391	388	388	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGPA	Q9UK23	391	425	420	420	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NAGPA	Q9UK23	264	306	132	323	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	375	391	380	389	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NAGPA	Q9UK23	391	425	310	515	Alternative sequence	ID=VSP_012268;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NAGPA	Q9UK23	375	391	310	515	Alternative sequence	ID=VSP_012268;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NAGPA	Q9UK23	391	425	392	425	Alternative sequence	ID=VSP_012269;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10551838;Dbxref=PMID:10551838
NAGPA	Q9UK23	264	306	284	284	Mutagenesis	Note=22%25 of wild-type of activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	264	306	286	286	Mutagenesis	Note=Complete loss of activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	264	306	287	287	Mutagenesis	Note=16%25 of wild-type of activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	264	306	288	288	Mutagenesis	Note=Complete loss of activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	264	306	289	289	Mutagenesis	Note=Complete loss of activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	264	306	290	290	Mutagenesis	Note=Complete loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527
NAGPA	Q9UK23	391	425	405	405	Sequence conflict	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NADK2	Q4G0N4	337	355	63	442	Chain	ID=PRO_0000296292;Note=NAD kinase 2%2C mitochondrial
NADK2	Q4G0N4	287	318	63	442	Chain	ID=PRO_0000296292;Note=NAD kinase 2%2C mitochondrial
NADK2	Q4G0N4	187	214	63	442	Chain	ID=PRO_0000296292;Note=NAD kinase 2%2C mitochondrial
NADK2	Q4G0N4	187	214	188	188	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NADK2	Q4G0N4	287	318	302	302	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5H8
NADK2	Q4G0N4	287	318	317	317	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5H8
NADK2	Q4G0N4	287	318	317	317	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5H8
NADK2	Q4G0N4	287	318	288	319	Alternative sequence	ID=VSP_027193;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
NLRP12	P59046	976	1032	1	1061	Chain	ID=PRO_0000080899;Note=NACHT%2C LRR and PYD domains-containing protein 12
NLRP12	P59046	919	975	1	1061	Chain	ID=PRO_0000080899;Note=NACHT%2C LRR and PYD domains-containing protein 12
NLRP12	P59046	862	918	1	1061	Chain	ID=PRO_0000080899;Note=NACHT%2C LRR and PYD domains-containing protein 12
NLRP12	P59046	805	861	1	1061	Chain	ID=PRO_0000080899;Note=NACHT%2C LRR and PYD domains-containing protein 12
NLRP12	P59046	748	804	1	1061	Chain	ID=PRO_0000080899;Note=NACHT%2C LRR and PYD domains-containing protein 12
NLRP12	P59046	691	747	1	1061	Chain	ID=PRO_0000080899;Note=NACHT%2C LRR and PYD domains-containing protein 12
NLRP12	P59046	805	861	828	848	Repeat	Note=LRR 1
NLRP12	P59046	862	918	857	878	Repeat	Note=LRR 2
NLRP12	P59046	805	861	857	878	Repeat	Note=LRR 2
NLRP12	P59046	862	918	885	906	Repeat	Note=LRR 3
NLRP12	P59046	919	975	914	935	Repeat	Note=LRR 4
NLRP12	P59046	862	918	914	935	Repeat	Note=LRR 4
NLRP12	P59046	919	975	942	962	Repeat	Note=LRR 5
NLRP12	P59046	976	1032	971	992	Repeat	Note=LRR 6
NLRP12	P59046	919	975	971	992	Repeat	Note=LRR 6
NLRP12	P59046	976	1032	999	1020	Repeat	Note=LRR 7
NLRP12	P59046	976	1032	1028	1049	Repeat	Note=LRR 8
NLRP12	P59046	691	747	1	717	Alternative sequence	ID=VSP_016908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11167794;Dbxref=PMID:11167794
NLRP12	P59046	691	747	691	691	Alternative sequence	ID=VSP_055193;Note=In isoform 7. L->LR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NLRP12	P59046	748	804	718	748	Alternative sequence	ID=VSP_016909;Note=In isoform 5. LSLYRNALGSRGVKLLCQGLRHPNCKLQNLR->MSQAWWHTSVSPATQEAKAGGLLQPRRQRLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11167794;Dbxref=PMID:11167794
NLRP12	P59046	691	747	718	748	Alternative sequence	ID=VSP_016909;Note=In isoform 5. LSLYRNALGSRGVKLLCQGLRHPNCKLQNLR->MSQAWWHTSVSPATQEAKAGGLLQPRRQRLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11167794;Dbxref=PMID:11167794
NLRP12	P59046	976	1032	862	1031	Alternative sequence	ID=VSP_009879;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NLRP12	P59046	919	975	862	1031	Alternative sequence	ID=VSP_009879;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NLRP12	P59046	862	918	862	1031	Alternative sequence	ID=VSP_009879;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NLRP12	P59046	919	975	862	973	Alternative sequence	ID=VSP_005523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NLRP12	P59046	862	918	862	973	Alternative sequence	ID=VSP_005523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NLRP12	P59046	976	1032	920	976	Alternative sequence	ID=VSP_054622;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NLRP12	P59046	919	975	920	976	Alternative sequence	ID=VSP_054622;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NLRP12	P59046	976	1032	921	977	Alternative sequence	ID=VSP_016910;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11167794;Dbxref=PMID:11167794
NLRP12	P59046	919	975	921	977	Alternative sequence	ID=VSP_016910;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11167794;Dbxref=PMID:11167794
NLRP12	P59046	976	1032	976	1031	Alternative sequence	ID=VSP_005524;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NRBP1	Q9UHY1	145	175	2	535	Chain	ID=PRO_0000086449;Note=Nuclear receptor-binding protein
NRBP1	Q9UHY1	381	397	2	535	Chain	ID=PRO_0000086449;Note=Nuclear receptor-binding protein
NRBP1	Q9UHY1	145	175	2	535	Chain	ID=PRO_0000086449;Note=Nuclear receptor-binding protein
NRBP1	Q9UHY1	381	397	2	535	Chain	ID=PRO_0000086449;Note=Nuclear receptor-binding protein
NRBP1	Q9UHY1	145	175	68	327	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NRBP1	Q9UHY1	145	175	68	327	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MTTP	P55157	131	167	19	894	Chain	ID=PRO_0000041593;Note=Microsomal triglyceride transfer protein large subunit
MTTP	P55157	131	167	19	894	Chain	ID=PRO_0000041593;Note=Microsomal triglyceride transfer protein large subunit
MTTP	P55157	131	167	28	659	Domain	Note=Vitellogenin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00557
MTTP	P55157	131	167	28	659	Domain	Note=Vitellogenin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00557
MTTP	P55157	131	167	134	151	Alternative sequence	ID=VSP_056325;Note=In isoform 2. EFYSYQNEAVAIENIKRG->GRLDSTTFSPTSYFSSLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTTP	P55157	131	167	134	151	Alternative sequence	ID=VSP_056325;Note=In isoform 2. EFYSYQNEAVAIENIKRG->GRLDSTTFSPTSYFSSLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTTP	P55157	131	167	152	894	Alternative sequence	ID=VSP_056326;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTTP	P55157	131	167	152	894	Alternative sequence	ID=VSP_056326;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MTTP	P55157	131	167	166	166	Natural variant	ID=VAR_052962;Note=N->S;Dbxref=dbSNP:rs3792683
MTTP	P55157	131	167	166	166	Natural variant	ID=VAR_052962;Note=N->S;Dbxref=dbSNP:rs3792683
N4BP1	O75113	742	777	1	896	Chain	ID=PRO_0000096680;Note=NEDD4-binding protein 1
N4BP1	O75113	706	741	1	896	Chain	ID=PRO_0000096680;Note=NEDD4-binding protein 1
N6AMT1	Q9Y5N5	104	132	1	214	Chain	ID=PRO_0000088049;Note=Methyltransferase N6AMT1
N6AMT1	Q9Y5N5	104	132	122	125	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0ACC1
N6AMT1	Q9Y5N5	104	132	122	122	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30017583;Dbxref=PMID:30017583
N6AMT1	Q9Y5N5	104	132	105	132	Alternative sequence	ID=VSP_040294;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
N6AMT1	Q9Y5N5	104	132	122	125	Mutagenesis	Note=Abolished DNA methyltransferase activity. NPPY->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30017583;Dbxref=PMID:30017583
SLC9A3R2	Q15599	138	198	1	337	Chain	ID=PRO_0000096805;Note=Na(+)/H(+) exchange regulatory cofactor NHE-RF2
SLC9A3R2	Q15599	138	198	150	230	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SLC9A3R2	Q15599	138	198	183	183	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SLC9A3R2	Q15599	138	198	28	138	Alternative sequence	ID=VSP_046850;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC9A3R2	Q15599	138	198	180	180	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC9A3R2	Q15599	138	198	150	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE4
SLC9A3R2	Q15599	138	198	163	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE4
SLC9A3R2	Q15599	138	198	169	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE4
SLC9A3R2	Q15599	138	198	184	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE4
SLC9A3R2	Q15599	138	198	195	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE4
SLC16A13	Q7RTY0	114	360	1	426	Chain	ID=PRO_0000287187;Note=Monocarboxylate transporter 13
SLC16A13	Q7RTY0	114	360	106	126	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	139	159	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	169	189	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	221	241	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	252	272	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	283	303	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	306	326	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC16A13	Q7RTY0	114	360	338	358	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAP2K3	P46734	55	93	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
MAP2K3	P46734	93	133	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
MAP2K3	P46734	232	258	1	347	Chain	ID=PRO_0000086378;Note=Dual specificity mitogen-activated protein kinase kinase 3
MAP2K3	P46734	55	93	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K3	P46734	93	133	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K3	P46734	232	258	64	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K3	P46734	55	93	70	78	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K3	P46734	55	93	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K3	P46734	93	133	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP2K3	P46734	55	93	55	55	Natural variant	ID=VAR_061742;Note=R->T;Dbxref=dbSNP:rs36047035
MAP2K3	P46734	55	93	68	68	Natural variant	ID=VAR_046063;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34105301,PMID:17344846
MAP2K3	P46734	55	93	84	84	Natural variant	ID=VAR_046064;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2305873,PMID:17344846
MAP2K3	P46734	55	93	90	90	Natural variant	ID=VAR_046065;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36076766,PMID:17344846
MAP2K3	P46734	93	133	94	94	Natural variant	ID=VAR_046066;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56067280,PMID:17344846
MAP2K3	P46734	93	133	96	96	Natural variant	ID=VAR_046067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56216806,PMID:17344846
NPC2	P61916	121	147	20	151	Chain	ID=PRO_0000019854;Note=NPC intracellular cholesterol transporter 2
NPC2	P61916	27	63	20	151	Chain	ID=PRO_0000019854;Note=NPC intracellular cholesterol transporter 2
NPC2	P61916	27	63	58	58	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5KWY,ECO:0000269|PubMed:17018531,ECO:0000269|PubMed:27551080;Dbxref=PMID:17018531,PMID:27551080
NPC2	P61916	121	147	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5KWY,ECO:0000269|PubMed:17018531,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:27551080;Dbxref=PMID:17018531,PMID:19159218,PMID:27551080
NPC2	P61916	121	147	27	140	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5KWY,ECO:0000269|PubMed:27551080;Dbxref=PMID:27551080
NPC2	P61916	27	63	27	140	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5KWY,ECO:0000269|PubMed:27551080;Dbxref=PMID:27551080
NPC2	P61916	27	63	42	47	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5KWY,ECO:0000269|PubMed:27551080;Dbxref=PMID:27551080
NPC2	P61916	121	147	122	147	Alternative sequence	ID=VSP_056459;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NPC2	P61916	27	63	30	30	Natural variant	ID=VAR_043303;Note=In NPC2. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12955717;Dbxref=dbSNP:rs151220873,PMID:12955717
NPC2	P61916	27	63	39	39	Natural variant	ID=VAR_015848;Note=In NPC2%3B results in the synthesis of functional recombinant proteins correctly targeted to lysosomes. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12447927,ECO:0000269|PubMed:15937921;Dbxref=dbSNP:rs80358261,PMID:12447927,PMID:15937921
NPC2	P61916	27	63	47	47	Natural variant	ID=VAR_043304;Note=In NPC2%3B leads to the synthesis of misfolded recombinant proteins that colocalized with an endoplasmic reticulum marker%3B normally secreted but unable to correct cholesterol storage in NPC2-deficient cells. C->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12955717,ECO:0000269|PubMed:15937921;Dbxref=PMID:12955717,PMID:15937921
NPC2	P61916	27	63	25	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KWY
NPC2	P61916	27	63	30	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KWY
NPC2	P61916	27	63	47	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KWY
NPC2	P61916	27	63	53	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KWY
NPC2	P61916	121	147	123	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KWY
NPC2	P61916	121	147	137	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KWY
MPP5	Q8N3R9	218	267	1	675	Chain	ID=PRO_0000094580;Note=MAGUK p55 subfamily member 5
MPP5	Q8N3R9	408	432	1	675	Chain	ID=PRO_0000094580;Note=MAGUK p55 subfamily member 5
MPP5	Q8N3R9	218	267	179	235	Domain	Note=L27 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
MPP5	Q8N3R9	218	267	256	336	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
MPP5	Q8N3R9	408	432	345	417	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
MPP5	Q8N3R9	218	267	181	243	Region	Note=Interaction with LIN7C;Ontology_term=ECO:0000250;evidence=ECO:0000250
MPP5	Q8N3R9	218	267	215	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIT
MPP5	Q8N3R9	218	267	230	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIT
MPP5	Q8N3R9	218	267	249	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WSI
MPP5	Q8N3R9	218	267	255	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UU5
MPP5	Q8N3R9	408	432	405	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WSI
MPP7	Q5T2T1	317	374	1	576	Chain	ID=PRO_0000320027;Note=MAGUK p55 subfamily member 7
MPP7	Q5T2T1	78	105	1	576	Chain	ID=PRO_0000320027;Note=MAGUK p55 subfamily member 7
MPP7	Q5T2T1	317	374	1	576	Chain	ID=PRO_0000320027;Note=MAGUK p55 subfamily member 7
MPP7	Q5T2T1	78	105	1	576	Chain	ID=PRO_0000320027;Note=MAGUK p55 subfamily member 7
MPP7	Q5T2T1	317	374	1	576	Chain	ID=PRO_0000320027;Note=MAGUK p55 subfamily member 7
MPP7	Q5T2T1	78	105	1	576	Chain	ID=PRO_0000320027;Note=MAGUK p55 subfamily member 7
MPP7	Q5T2T1	78	105	67	122	Domain	Note=L27 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
MPP7	Q5T2T1	78	105	67	122	Domain	Note=L27 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
MPP7	Q5T2T1	78	105	67	122	Domain	Note=L27 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00365
MPP7	Q5T2T1	317	374	368	560	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP7	Q5T2T1	317	374	368	560	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP7	Q5T2T1	317	374	368	560	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
MPP7	Q5T2T1	78	105	1	125	Alternative sequence	ID=VSP_056065;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MPP7	Q5T2T1	78	105	1	125	Alternative sequence	ID=VSP_056065;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MPP7	Q5T2T1	78	105	1	125	Alternative sequence	ID=VSP_056065;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MPP7	Q5T2T1	317	374	322	322	Natural variant	ID=VAR_039110;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2997211,PMID:14702039,PMID:15489334
MPP7	Q5T2T1	317	374	322	322	Natural variant	ID=VAR_039110;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2997211,PMID:14702039,PMID:15489334
MPP7	Q5T2T1	317	374	322	322	Natural variant	ID=VAR_039110;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2997211,PMID:14702039,PMID:15489334
MPP7	Q5T2T1	78	105	95	95	Mutagenesis	Note=Does not affect the interaction with DLG1. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17332497;Dbxref=PMID:17332497
MPP7	Q5T2T1	78	105	95	95	Mutagenesis	Note=Does not affect the interaction with DLG1. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17332497;Dbxref=PMID:17332497
MPP7	Q5T2T1	78	105	95	95	Mutagenesis	Note=Does not affect the interaction with DLG1. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17332497;Dbxref=PMID:17332497
MPP7	Q5T2T1	78	105	72	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	72	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	72	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	90	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	90	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	90	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	102	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	102	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPP7	Q5T2T1	78	105	102	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRA
MPHOSPH8	Q99549	71	123	1	860	Chain	ID=PRO_0000080244;Note=M-phase phosphoprotein 8
MPHOSPH8	Q99549	597	644	1	860	Chain	ID=PRO_0000080244;Note=M-phase phosphoprotein 8
MPHOSPH8	Q99549	819	847	1	860	Chain	ID=PRO_0000080244;Note=M-phase phosphoprotein 8
MPHOSPH8	Q99549	71	123	59	118	Domain	Note=Chromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
MPHOSPH8	Q99549	597	644	600	629	Repeat	Note=ANK 1
MPHOSPH8	Q99549	597	644	633	662	Repeat	Note=ANK 2
MPHOSPH8	Q99549	71	123	80	87	Region	Note=Histone H3K9me3 binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21419134;Dbxref=PMID:21419134
MPHOSPH8	Q99549	71	123	85	85	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TYA6
MPHOSPH8	Q99549	819	847	820	860	Alternative sequence	ID=VSP_031523;Note=In isoform 2. DSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ->TGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
MPHOSPH8	Q99549	71	123	80	80	Mutagenesis	Note=Abolishes interaction with histone H3K9me3 and prevents recruitment of the HUSH complex to heterochromatin. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20871592,ECO:0000269|PubMed:26022416;Dbxref=PMID:20871592,PMID:26022416
MPHOSPH8	Q99549	71	123	73	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LWE
MPHOSPH8	Q99549	71	123	85	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LWE
MPHOSPH8	Q99549	71	123	89	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LWE
MPHOSPH8	Q99549	71	123	93	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LWE
MPHOSPH8	Q99549	71	123	100	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LWE
MIS18A	Q9NYP9	134	174	1	233	Chain	ID=PRO_0000079515;Note=Protein Mis18-alpha
MIS18A	Q9NYP9	134	174	80	178	Domain	Note=Mis18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01129
MIS18A	Q9NYP9	134	174	141	141	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01129
MIS18A	Q9NYP9	134	174	144	144	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01129
MIS18A	Q9NYP9	134	174	162	162	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MIS18A	Q9NYP9	134	174	134	134	Mutagenesis	Note=No effect. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17199038;Dbxref=PMID:17199038
MIS18A	Q9NYP9	134	174	141	141	Mutagenesis	Note=Abolishes location at the centromere. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17199038;Dbxref=PMID:17199038
MIS18A	Q9NYP9	134	174	144	144	Mutagenesis	Note=Abolishes location at the centromere. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17199038;Dbxref=PMID:17199038
MUC15	Q8N387	231	281	24	334	Chain	ID=PRO_0000019288;Note=Mucin-15
MUC15	Q8N387	231	281	24	236	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MUC15	Q8N387	231	281	237	257	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MUC15	Q8N387	231	281	258	334	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MUC15	Q8N387	231	281	232	281	Alternative sequence	ID=VSP_010825;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12047385;Dbxref=PMID:12047385
MYH2	Q9UKX2	1859	1891	1	1941	Chain	ID=PRO_0000123393;Note=Myosin-2
MYH2	Q9UKX2	1859	1891	1	1941	Chain	ID=PRO_0000123393;Note=Myosin-2
MYH2	Q9UKX2	1859	1891	845	1941	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH2	Q9UKX2	1859	1891	845	1941	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYH2	Q9UKX2	1859	1891	659	1891	Alternative sequence	ID=VSP_056291;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYH2	Q9UKX2	1859	1891	659	1891	Alternative sequence	ID=VSP_056291;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MUC16	Q8WXI7	14434	14448	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	14051	14068	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	14039	14051	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	13905	13917	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	13438	13450	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	13294	13316	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	12022	12034	1	14507	Chain	ID=PRO_0000436078;Note=Mucin-16
MUC16	Q8WXI7	14434	14448	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	14051	14068	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	14039	14051	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	13905	13917	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	13438	13450	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	13294	13316	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	12022	12034	1	14451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
MUC16	Q8WXI7	13294	13316	13161	13316	Repeat	Note=8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786729;Dbxref=PMID:11786729
MUC16	Q8WXI7	13438	13450	13317	13472	Repeat	Note=9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786729;Dbxref=PMID:11786729
MUC16	Q8WXI7	13438	13450	13321	13442	Domain	Note=SEA 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
MUC16	Q8WXI7	13905	13917	13785	13939	Repeat	Note=12;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786729;Dbxref=PMID:11786729
MUC16	Q8WXI7	13905	13917	13789	13909	Domain	Note=SEA 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
MUC16	Q8WXI7	14039	14051	13922	14043	Domain	Note=SEA 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
MUC16	Q8WXI7	14434	14448	14319	14438	Domain	Note=SEA 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
MUC16	Q8WXI7	13905	13917	12067	13939	Region	Note=12 X approximate tandem repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786729;Dbxref=PMID:11786729
MUC16	Q8WXI7	13438	13450	12067	13939	Region	Note=12 X approximate tandem repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786729;Dbxref=PMID:11786729
MUC16	Q8WXI7	13294	13316	12067	13939	Region	Note=12 X approximate tandem repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786729;Dbxref=PMID:11786729
MUC16	Q8WXI7	12022	12034	14	12083	Compositional bias	Note=Thr-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00017
MUC16	Q8WXI7	14039	14051	14041	14050	Sequence conflict	Note=YNEPGPDEPP->HHTLQRQSTT;Ontology_term=ECO:0000305;evidence=ECO:0000305
MXRA8	Q9BRK3	24	125	20	442	Chain	ID=PRO_0000298665;Note=Matrix remodeling-associated protein 8
MXRA8	Q9BRK3	24	125	20	341	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MXRA8	Q9BRK3	24	125	29	157	Domain	Note=Ig-like V-type 1
MXRA8	Q9BRK3	24	125	119	119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MXRA8	Q9BRK3	24	125	54	137	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
MXRA8	Q9BRK3	24	125	25	125	Alternative sequence	ID=VSP_054529;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MX2	P20592	147	192	1	715	Chain	ID=PRO_0000206598;Note=Interferon-induced GTP-binding protein Mx2
MX2	P20592	147	192	115	387	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
MX2	P20592	147	192	150	152	Region	Note=G2 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
MX2	P20592	147	192	148	192	Alternative sequence	ID=VSP_056443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MX2	P20592	147	192	151	151	Mutagenesis	Note=Defective GTP-hydrolysis. Disruption of nuclear import and cell-cycle progression. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15184662;Dbxref=PMID:15184662
MX2	P20592	147	192	155	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WHJ
MX2	P20592	147	192	167	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WHJ
MX2	P20592	147	192	173	175	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WHJ
MX2	P20592	147	192	176	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WHJ
MX2	P20592	147	192	183	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WHJ
MYBL1	P10243	650	710	1	752	Chain	ID=PRO_0000197054;Note=Myb-related protein A
MYBL1	P10243	367	490	1	752	Chain	ID=PRO_0000197054;Note=Myb-related protein A
MYBL1	P10243	367	490	298	553	Region	Note=Negative regulatory domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
MYBL1	P10243	367	490	394	394	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MYBL1	P10243	650	710	650	709	Alternative sequence	ID=VSP_042912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYL6B	P14649	67	115	1	208	Chain	ID=PRO_0000198695;Note=Myosin light chain 6B
MYL6B	P14649	67	115	1	208	Chain	ID=PRO_0000198695;Note=Myosin light chain 6B
MYL6B	P14649	67	115	64	99	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL6B	P14649	67	115	64	99	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
MYL6B	P14649	67	115	69	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	69	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	79	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	79	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	89	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	89	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	114	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYL6B	P14649	67	115	114	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W7J
MYO15A	Q9UKN7	1970	1988	1	3530	Chain	ID=PRO_0000123474;Note=Unconventional myosin-XV
MYO15A	Q9UKN7	3450	3497	1	3530	Chain	ID=PRO_0000123474;Note=Unconventional myosin-XV
MYO15A	Q9UKN7	1970	1988	1955	1976	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
MYO15A	Q9UKN7	3450	3497	3209	3530	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
MYO15A	Q9UKN7	1970	1988	1888	2029	Region	Note=Neck or regulatory domain
MYO15A	Q9UKN7	3450	3497	2030	3530	Region	Note=Tail
MYO15A	Q9UKN7	1970	1988	1	2736	Alternative sequence	ID=VSP_056655;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MYO15A	Q9UKN7	1970	1988	1977	1977	Natural variant	ID=VAR_037959;Note=C->R;Dbxref=dbSNP:rs854777
IGF2R	P11717	493	540	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	540	588	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	588	634	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	1030	1087	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	1223	1295	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	1523	1563	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	1772	1826	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	2281	2331	41	2491	Chain	ID=PRO_0000019229;Note=Cation-independent mannose-6-phosphate receptor
IGF2R	P11717	493	540	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	540	588	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	588	634	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	1030	1087	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	1223	1295	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	1523	1563	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	1772	1826	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	2281	2331	41	2304	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	2281	2331	2305	2327	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	2281	2331	2328	2491	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	493	540	490	643	Repeat	Note=4
IGF2R	P11717	540	588	490	643	Repeat	Note=4
IGF2R	P11717	588	634	490	643	Repeat	Note=4
IGF2R	P11717	1030	1087	951	1099	Repeat	Note=7
IGF2R	P11717	1223	1295	1100	1243	Repeat	Note=8
IGF2R	P11717	1223	1295	1244	1384	Repeat	Note=9
IGF2R	P11717	1523	1563	1385	1532	Repeat	Note=10
IGF2R	P11717	1523	1563	1533	1666	Repeat	Note=11
IGF2R	P11717	1772	1826	1667	1820	Repeat	Note=12
IGF2R	P11717	1772	1826	1821	2008	Repeat	Note=13
IGF2R	P11717	2281	2331	2165	2289	Repeat	Note=15
IGF2R	P11717	540	588	543	543	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	540	588	581	581	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
IGF2R	P11717	588	634	626	626	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
IGF2R	P11717	1223	1295	1246	1246	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
IGF2R	P11717	1772	1826	1816	1816	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGF2R	P11717	588	634	627	664	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
IGF2R	P11717	1523	1563	1516	1553	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00479,ECO:0000269|PubMed:18046459;Dbxref=PMID:18046459
IGF2R	P11717	1523	1563	1559	1566	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00479,ECO:0000269|PubMed:18046459;Dbxref=PMID:18046459
IGF2R	P11717	1772	1826	1750	1783	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00479,ECO:0000269|PubMed:18046459;Dbxref=PMID:18046459
IGF2R	P11717	1772	1826	1766	1795	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00479,ECO:0000269|PubMed:18046459;Dbxref=PMID:18046459
IGF2R	P11717	1772	1826	1804	1839	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00479,ECO:0000269|PubMed:18046459;Dbxref=PMID:18046459
IGF2R	P11717	493	540	512	512	Natural variant	ID=VAR_021307;Note=K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs8191776
IGF2R	P11717	493	540	529	529	Natural variant	ID=VAR_020472;Note=R->Q;Dbxref=dbSNP:rs6413489
IGF2R	P11717	588	634	604	604	Natural variant	ID=VAR_020473;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs8191797
IGF2R	P11717	1223	1295	1254	1254	Natural variant	ID=VAR_050428;Note=E->A;Dbxref=dbSNP:rs2230043
IGF2R	P11717	493	540	510	510	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2R	P11717	588	634	612	612	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2R	P11717	588	634	612	612	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2R	P11717	2281	2331	2330	2330	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2R	P11717	1523	1563	1521	1523	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1526	1528	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1530	1532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1533	1536	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1538	1542	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1543	1545	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1546	1550	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1552	1554	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1523	1563	1558	1560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L2A
IGF2R	P11717	1523	1563	1563	1567	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GP0
IGF2R	P11717	1772	1826	1775	1777	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1781	1783	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1784	1791	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1792	1794	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1801	1804	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1805	1807	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1809	1811	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1814	1816	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1818	1821	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
IGF2R	P11717	1772	1826	1825	1829	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5O
MCAM	P43121	516	548	24	646	Chain	ID=PRO_0000014891;Note=Cell surface glycoprotein MUC18
MCAM	P43121	516	548	24	559	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCAM	P43121	516	548	518	518	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCAM	P43121	516	548	527	527	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MCAM	P43121	516	548	544	544	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO18A	Q92614	1951	1965	1	2054	Chain	ID=PRO_0000123476;Note=Unconventional myosin-XVIIIa
MYO18A	Q92614	1607	1642	1	2054	Chain	ID=PRO_0000123476;Note=Unconventional myosin-XVIIIa
MYO18A	Q92614	1570	1607	1	2054	Chain	ID=PRO_0000123476;Note=Unconventional myosin-XVIIIa
MYO18A	Q92614	1147	1169	1	2054	Chain	ID=PRO_0000123476;Note=Unconventional myosin-XVIIIa
MYO18A	Q92614	398	457	1	2054	Chain	ID=PRO_0000123476;Note=Unconventional myosin-XVIIIa
MYO18A	Q92614	398	457	349	401	Domain	Note=Myosin N-terminal SH3-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01190
MYO18A	Q92614	1147	1169	405	1185	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO18A	Q92614	398	457	405	1185	Domain	Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
MYO18A	Q92614	398	457	1	398	Region	Note=Mediates nucleotide-independent binding to F-actin and interaction with GOLPH3
MYO18A	Q92614	1951	1965	1246	1971	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO18A	Q92614	1607	1642	1246	1971	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO18A	Q92614	1570	1607	1246	1971	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MYO18A	Q92614	1607	1642	1640	1640	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
MYO18A	Q92614	398	457	1	458	Alternative sequence	ID=VSP_023058;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15491607;Dbxref=PMID:15491607
MYO18A	Q92614	1607	1642	1571	1607	Alternative sequence	ID=VSP_007871;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO18A	Q92614	1570	1607	1571	1607	Alternative sequence	ID=VSP_007871;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYO18A	Q92614	1951	1965	1952	1966	Alternative sequence	ID=VSP_007872;Note=In isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15491607,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:15491607,PMID:17974005
MYBL2	P10244	38	62	1	700	Chain	ID=PRO_0000197058;Note=Myb-related protein B
MYBL2	P10244	317	455	1	700	Chain	ID=PRO_0000197058;Note=Myb-related protein B
MYBL2	P10244	608	658	1	700	Chain	ID=PRO_0000197058;Note=Myb-related protein B
MYBL2	P10244	38	62	26	77	Domain	Note=HTH myb-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00625
MYBL2	P10244	38	62	54	77	DNA binding	Note=H-T-H motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00625
MYBL2	P10244	317	455	411	417	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8062924;Dbxref=PMID:8062924
MYBL2	P10244	317	455	393	393	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MYBL2	P10244	317	455	440	440	Modified residue	Note=Phosphothreonine%3B by CDK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10095772;Dbxref=PMID:10095772
MYBL2	P10244	317	455	444	444	Modified residue	Note=Phosphothreonine%3B by CDK2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10095772,ECO:0000269|PubMed:9840932;Dbxref=PMID:10095772,PMID:9840932
MYBL2	P10244	317	455	411	411	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MYBL2	P10244	317	455	447	447	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MYBL2	P10244	608	658	625	625	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MYBL2	P10244	608	658	639	639	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
MYBL2	P10244	608	658	648	648	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MYBL2	P10244	38	62	39	62	Alternative sequence	ID=VSP_053987;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MYBL2	P10244	317	455	341	341	Natural variant	ID=VAR_050190;Note=N->S;Dbxref=dbSNP:rs6017146
MYBL2	P10244	317	455	427	427	Natural variant	ID=VAR_020422;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2070235,PMID:14702039
MYBL2	P10244	608	658	624	624	Natural variant	ID=VAR_050192;Note=I->M;Dbxref=dbSNP:rs11556379
MYCBPAP	Q8TBZ2	894	951	1	947	Chain	ID=PRO_0000302877;Note=MYCBP-associated protein
MYCBPAP	Q8TBZ2	894	951	910	910	Natural variant	ID=VAR_035005;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11230166,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1133818,PMID:11230166,PMID:15489334
C12orf10	Q9HB07	163	214	48	376	Chain	ID=PRO_0000213483;Note=UPF0160 protein MYG1%2C mitochondrial
C12orf10	Q9HB07	214	255	48	376	Chain	ID=PRO_0000213483;Note=UPF0160 protein MYG1%2C mitochondrial
NACC2	Q96BF6	295	350	1	587	Chain	ID=PRO_0000263668;Note=Nucleus accumbens-associated protein 2
NACC2	Q96BF6	295	350	299	299	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
LIPF	P07098	223	272	20	398	Chain	ID=PRO_0000017766;Note=Gastric triacylglycerol lipase
LIPF	P07098	272	296	20	398	Chain	ID=PRO_0000017766;Note=Gastric triacylglycerol lipase
LIPF	P07098	296	320	20	398	Chain	ID=PRO_0000017766;Note=Gastric triacylglycerol lipase
LIPF	P07098	223	272	78	377	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPF	P07098	272	296	78	377	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPF	P07098	296	320	78	377	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
LIPF	P07098	223	272	271	271	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10358049;Dbxref=PMID:10358049
LIPF	P07098	223	272	246	255	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10358049;Dbxref=PMID:10358049
LIPF	P07098	223	272	224	224	Natural variant	ID=VAR_020565;Note=F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs6586145
LIPF	P07098	223	272	219	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	223	272	228	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	223	272	234	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	223	272	241	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	223	272	252	255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	223	272	258	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	223	272	272	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	272	296	272	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	272	296	275	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	272	296	288	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	296	320	288	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	296	320	311	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
LIPF	P07098	296	320	319	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HLG
PNLIP	P16233	67	108	17	465	Chain	ID=PRO_0000017785;Note=Pancreatic triacylglycerol lipase
PNLIP	P16233	108	153	17	465	Chain	ID=PRO_0000017785;Note=Pancreatic triacylglycerol lipase
PNLIP	P16233	67	108	107	118	Disulfide bond	.
PNLIP	P16233	108	153	107	118	Disulfide bond	.
PNLIP	P16233	67	108	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	67	108	73	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	67	108	87	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	67	108	101	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	108	153	101	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	108	153	111	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	108	153	117	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	108	153	124	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
PNLIP	P16233	108	153	131	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LPB
L3MBTL3	Q96JM7	71	96	1	780	Chain	ID=PRO_0000084450;Note=Lethal(3)malignant brain tumor-like protein 3
L3MBTL3	Q96JM7	579	628	1	780	Chain	ID=PRO_0000084450;Note=Lethal(3)malignant brain tumor-like protein 3
L3MBTL3	Q96JM7	71	96	1	780	Chain	ID=PRO_0000084450;Note=Lethal(3)malignant brain tumor-like protein 3
L3MBTL3	Q96JM7	579	628	1	780	Chain	ID=PRO_0000084450;Note=Lethal(3)malignant brain tumor-like protein 3
L3MBTL3	Q96JM7	71	96	1	780	Chain	ID=PRO_0000084450;Note=Lethal(3)malignant brain tumor-like protein 3
L3MBTL3	Q96JM7	579	628	1	780	Chain	ID=PRO_0000084450;Note=Lethal(3)malignant brain tumor-like protein 3
L3MBTL3	Q96JM7	579	628	549	593	Zinc finger	Note=CCHHC-type%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
L3MBTL3	Q96JM7	579	628	549	593	Zinc finger	Note=CCHHC-type%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
L3MBTL3	Q96JM7	579	628	549	593	Zinc finger	Note=CCHHC-type%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
L3MBTL3	Q96JM7	579	628	608	608	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
L3MBTL3	Q96JM7	579	628	608	608	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
L3MBTL3	Q96JM7	579	628	608	608	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
L3MBTL3	Q96JM7	71	96	72	96	Alternative sequence	ID=VSP_013508;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
L3MBTL3	Q96JM7	71	96	72	96	Alternative sequence	ID=VSP_013508;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
L3MBTL3	Q96JM7	71	96	72	96	Alternative sequence	ID=VSP_013508;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIX1	Q8N485	82	129	1	282	Chain	ID=PRO_0000232869;Note=Protein limb expression 1 homolog
LMAN1L	Q9HAT1	110	146	26	526	Chain	ID=PRO_0000017663;Note=Protein ERGIC-53-like
LMAN1L	Q9HAT1	110	146	26	462	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
LMAN1L	Q9HAT1	110	146	31	252	Domain	Note=L-type lectin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00658
LPIN2	Q92539	696	724	1	896	Chain	ID=PRO_0000209881;Note=Phosphatidate phosphatase LPIN2
LPIN2	Q92539	696	724	635	837	Region	Note=C-LIP
LPIN2	Q92539	696	724	700	704	Motif	Note=LXXIL motif
LDLRAD3	Q86YD5	15	64	1	17	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD3	Q86YD5	15	64	18	345	Chain	ID=PRO_0000299378;Note=Low-density lipoprotein receptor class A domain-containing protein 3
LDLRAD3	Q86YD5	64	106	18	345	Chain	ID=PRO_0000299378;Note=Low-density lipoprotein receptor class A domain-containing protein 3
LDLRAD3	Q86YD5	106	151	18	345	Chain	ID=PRO_0000299378;Note=Low-density lipoprotein receptor class A domain-containing protein 3
LDLRAD3	Q86YD5	15	64	18	173	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD3	Q86YD5	64	106	18	173	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD3	Q86YD5	106	151	18	173	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD3	Q86YD5	15	64	28	65	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	64	106	28	65	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	64	106	70	107	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	106	151	70	107	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	106	151	112	148	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	15	64	24	24	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LDLRAD3	Q86YD5	15	64	29	42	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	15	64	37	55	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	15	64	49	64	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	64	106	49	64	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	64	106	71	84	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	64	106	78	97	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	64	106	91	106	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	106	151	91	106	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	106	151	113	125	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	106	151	120	138	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	106	151	132	147	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
LDLRAD3	Q86YD5	15	64	16	65	Alternative sequence	ID=VSP_056254;Note=In isoform 2. ESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECP->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LDLRAD3	Q86YD5	64	106	16	65	Alternative sequence	ID=VSP_056254;Note=In isoform 2. ESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECP->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LRRC29	Q8WV35	47	95	1	223	Chain	ID=PRO_0000119852;Note=Leucine-rich repeat-containing protein 29
LRRC29	Q8WV35	47	95	27	48	Repeat	Note=LRR 1
LRRC29	Q8WV35	47	95	56	84	Repeat	Note=LRR 2
LRRC29	Q8WV35	47	95	85	109	Repeat	Note=LRR 3
LRRC29	Q8WV35	47	95	75	75	Natural variant	ID=VAR_049031;Note=R->Q;Dbxref=dbSNP:rs3743728
LRRCC1	Q9C099	240	310	1	1032	Chain	ID=PRO_0000337081;Note=Leucine-rich repeat and coiled-coil domain-containing protein 1
LRRCC1	Q9C099	656	718	1	1032	Chain	ID=PRO_0000337081;Note=Leucine-rich repeat and coiled-coil domain-containing protein 1
LRRCC1	Q9C099	901	946	1	1032	Chain	ID=PRO_0000337081;Note=Leucine-rich repeat and coiled-coil domain-containing protein 1
LRRCC1	Q9C099	656	718	687	687	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
LSM4	Q9Y4Z0	15	48	1	139	Chain	ID=PRO_0000125564;Note=U6 snRNA-associated Sm-like protein LSm4
SELE	P16581	363	426	22	610	Chain	ID=PRO_0000017492;Note=E-selectin
SELE	P16581	176	238	22	610	Chain	ID=PRO_0000017492;Note=E-selectin
SELE	P16581	363	426	22	556	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELE	P16581	176	238	22	556	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SELE	P16581	176	238	178	239	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELE	P16581	363	426	303	364	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELE	P16581	363	426	366	427	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SELE	P16581	176	238	179	179	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4C16,ECO:0000244|PDB:4CSY,ECO:0000269|PubMed:26117840;Dbxref=PMID:26117840
SELE	P16581	176	238	199	199	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4C16,ECO:0000244|PDB:4CSY,ECO:0000269|PubMed:26117840;Dbxref=PMID:26117840
SELE	P16581	176	238	203	203	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4C16,ECO:0000244|PDB:4CSY,ECO:0000269|PubMed:26117840;Dbxref=PMID:26117840
SELE	P16581	176	238	180	224	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4C16,ECO:0000244|PDB:4CSY,ECO:0000269|PubMed:26117840;Dbxref=PMID:26117840
SELE	P16581	176	238	193	206	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4C16,ECO:0000244|PDB:4CSY,ECO:0000269|PubMed:26117840;Dbxref=PMID:26117840
SELE	P16581	176	238	210	237	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4C16,ECO:0000244|PDB:4CSY,ECO:0000269|PubMed:26117840;Dbxref=PMID:26117840
SELE	P16581	363	426	367	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELE	P16581	363	426	398	425	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SELE	P16581	363	426	421	421	Natural variant	ID=VAR_011792;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs5366
SELE	P16581	176	238	189	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
SELE	P16581	176	238	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
SELE	P16581	176	238	205	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
SELE	P16581	176	238	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
SELE	P16581	176	238	222	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
SELE	P16581	176	238	230	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
SELE	P16581	176	238	237	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C16
LYPD6	Q86Y78	39	72	23	171	Chain	ID=PRO_0000036178;Note=Ly6/PLAUR domain-containing protein 6
LYPD6	Q86Y78	39	72	23	171	Chain	ID=PRO_0000036178;Note=Ly6/PLAUR domain-containing protein 6
LYPD6	Q86Y78	39	72	47	141	Domain	Note=UPAR/Ly6
LYPD6	Q86Y78	39	72	47	141	Domain	Note=UPAR/Ly6
LZTFL1	Q9NQ48	174	200	1	299	Chain	ID=PRO_0000318757;Note=Leucine zipper transcription factor-like protein 1
LZTFL1	Q9NQ48	152	174	1	299	Chain	ID=PRO_0000318757;Note=Leucine zipper transcription factor-like protein 1
LZTFL1	Q9NQ48	174	200	145	299	Region	Note=Interaction with BSS9
LZTFL1	Q9NQ48	152	174	145	299	Region	Note=Interaction with BSS9
LZTFL1	Q9NQ48	174	200	96	296	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LZTFL1	Q9NQ48	152	174	96	296	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LZTFL1	Q9NQ48	152	174	152	152	Natural variant	ID=VAR_038877;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855512,PMID:15489334
LZTR1	Q8N653	88	106	2	840	Chain	ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1
LZTR1	Q8N653	170	197	2	840	Chain	ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1
LZTR1	Q8N653	383	420	2	840	Chain	ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1
LZTR1	Q8N653	775	802	2	840	Chain	ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1
LZTR1	Q8N653	88	106	79	128	Repeat	Note=Kelch 1
LZTR1	Q8N653	170	197	130	185	Repeat	Note=Kelch 2
LZTR1	Q8N653	170	197	187	238	Repeat	Note=Kelch 3
LZTR1	Q8N653	383	420	399	450	Repeat	Note=Kelch 6
LZTR1	Q8N653	383	420	404	404	Natural variant	ID=VAR_071146;Note=In SWNTS2. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24362817;Dbxref=PMID:24362817
M1AP	Q8TC57	427	474	1	530	Chain	ID=PRO_0000349268;Note=Meiosis 1 arrest protein
M1AP	Q8TC57	358	427	1	530	Chain	ID=PRO_0000349268;Note=Meiosis 1 arrest protein
M1AP	Q8TC57	198	256	1	530	Chain	ID=PRO_0000349268;Note=Meiosis 1 arrest protein
M1AP	Q8TC57	80	142	1	530	Chain	ID=PRO_0000349268;Note=Meiosis 1 arrest protein
M1AP	Q8TC57	198	256	1	282	Alternative sequence	ID=VSP_035291;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
M1AP	Q8TC57	80	142	1	282	Alternative sequence	ID=VSP_035291;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
M1AP	Q8TC57	427	474	359	427	Alternative sequence	ID=VSP_035292;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
M1AP	Q8TC57	358	427	359	427	Alternative sequence	ID=VSP_035292;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
M1AP	Q8TC57	358	427	359	365	Alternative sequence	ID=VSP_035293;Note=In isoform 2. KREWLLL->VSTHVPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
M1AP	Q8TC57	427	474	366	530	Alternative sequence	ID=VSP_035294;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
M1AP	Q8TC57	358	427	366	530	Alternative sequence	ID=VSP_035294;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
M1AP	Q8TC57	427	474	474	477	Alternative sequence	ID=VSP_055677;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
M1AP	Q8TC57	358	427	359	359	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K12	Q12852	459	504	1	859	Chain	ID=PRO_0000086261;Note=Mitogen-activated protein kinase kinase kinase 12
MAP3K12	Q12852	459	504	443	464	Region	Note=Leucine-zipper 2
MAP3K12	Q12852	459	504	498	498	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K12	Q12852	459	504	504	504	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
MDN1	Q9NU22	4598	4652	1	5596	Chain	ID=PRO_0000096336;Note=Midasin
MDN1	Q9NU22	3857	3906	1	5596	Chain	ID=PRO_0000096336;Note=Midasin
MDN1	Q9NU22	575	607	1	5596	Chain	ID=PRO_0000096336;Note=Midasin
MDN1	Q9NU22	575	607	307	591	Region	Note=AAA-ATPase protomer 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
MDN1	Q9NU22	4598	4652	2418	4691	Region	Note=Linker;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q12019
MDN1	Q9NU22	3857	3906	2418	4691	Region	Note=Linker;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q12019
MAP3K5	Q99683	613	644	1	1374	Chain	ID=PRO_0000086249;Note=Mitogen-activated protein kinase kinase kinase 5
MAP3K5	Q99683	560	596	1	1374	Chain	ID=PRO_0000086249;Note=Mitogen-activated protein kinase kinase kinase 5
MAP3K5	Q99683	613	644	1	753	Alternative sequence	ID=VSP_056182;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP3K5	Q99683	560	596	1	753	Alternative sequence	ID=VSP_056182;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP3K5	Q99683	560	596	557	564	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	560	596	570	578	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	560	596	581	583	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	560	596	585	592	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	613	644	609	614	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	613	644	621	626	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	613	644	633	636	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MAP3K5	Q99683	613	644	640	654	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ULM
MACROD1	Q9BQ69	182	221	1	325	Chain	ID=PRO_0000084485;Note=O-acetyl-ADP-ribose deacetylase MACROD1
MACROD1	Q9BQ69	172	182	1	325	Chain	ID=PRO_0000084485;Note=O-acetyl-ADP-ribose deacetylase MACROD1
MACROD1	Q9BQ69	133	172	1	325	Chain	ID=PRO_0000084485;Note=O-acetyl-ADP-ribose deacetylase MACROD1
MACROD1	Q9BQ69	182	221	141	322	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
MACROD1	Q9BQ69	172	182	141	322	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
MACROD1	Q9BQ69	133	172	141	322	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
MACROD1	Q9BQ69	133	172	159	161	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
MACROD1	Q9BQ69	172	182	172	174	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
MACROD1	Q9BQ69	133	172	172	174	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
MACROD1	Q9BQ69	182	221	179	184	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
MACROD1	Q9BQ69	172	182	179	184	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
MACROD1	Q9BQ69	133	172	163	163	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q922B1
MACROD1	Q9BQ69	133	172	138	138	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MACROD1	Q9BQ69	133	172	160	160	Mutagenesis	Note=Reduced enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21257746;Dbxref=PMID:21257746
MACROD1	Q9BQ69	133	172	167	167	Mutagenesis	Note=Reduced enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21257746;Dbxref=PMID:21257746
MACROD1	Q9BQ69	133	172	171	171	Mutagenesis	Note=Reduced enzyme activity. No significant effect on affinity for substrate. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21257746;Dbxref=PMID:21257746
MACROD1	Q9BQ69	172	182	174	174	Mutagenesis	Note=Slightly reduced ADP-ribosyl hydrolase activity%3B when associated with A-184. Reduces O-acetyl-ADP-ribose deacetylase activity by 93%25%3B when associated with A-184. No significant effect on affinity for substrate. N->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21257746,ECO:0000269|PubMed:23474712;Dbxref=PMID:21257746,PMID:23474712
MACROD1	Q9BQ69	182	221	184	184	Mutagenesis	Note=Slightly reduced ADP-ribosyl hydrolase activity%3B when associated with A-174. Reduces O-acetyl-ADP-ribose deacetylase activity by 93%25%3B when associated with A-174. No significant effect on affinity for substrate. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21257746,ECO:0000269|PubMed:23474712;Dbxref=PMID:21257746,PMID:23474712
MACROD1	Q9BQ69	182	221	188	188	Mutagenesis	Note=Reduced enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21257746;Dbxref=PMID:21257746
MACROD1	Q9BQ69	133	172	148	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	133	172	154	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	133	172	161	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	172	182	164	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	133	172	164	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	182	221	182	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	172	182	182	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	182	221	193	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	182	221	210	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MACROD1	Q9BQ69	182	221	218	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X47
MAN1C1	Q9NR34	251	278	1	630	Chain	ID=PRO_0000210315;Note=Mannosyl-oligosaccharide 1%2C2-alpha-mannosidase IC
MAN1C1	Q9NR34	251	278	44	630	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAEA	Q7L5Y9	84	152	1	396	Chain	ID=PRO_0000284936;Note=E3 ubiquitin-protein transferase MAEA
MAEA	Q7L5Y9	152	193	1	396	Chain	ID=PRO_0000284936;Note=E3 ubiquitin-protein transferase MAEA
MAEA	Q7L5Y9	84	152	121	153	Domain	Note=LisH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00126
MAEA	Q7L5Y9	152	193	121	153	Domain	Note=LisH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00126
MAEA	Q7L5Y9	152	193	159	216	Domain	Note=CTLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00058
MAEA	Q7L5Y9	84	152	1	124	Region	Note=Extracellular and involved in cell to cell contact;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9763581;Dbxref=PMID:9763581
MAEA	Q7L5Y9	84	152	152	232	Alternative sequence	ID=VSP_024784;Note=In isoform 4. EDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQ->GTCKKALQPSRREPAGRGAPGHGHAGLPARHAHLPVQGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAEA	Q7L5Y9	152	193	152	232	Alternative sequence	ID=VSP_024784;Note=In isoform 4. EDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQ->GTCKKALQPSRREPAGRGAPGHGHAGLPARHAHLPVQGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAEA	Q7L5Y9	152	193	153	245	Alternative sequence	ID=VSP_024785;Note=In isoform 5. DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF->TCKKALQPSRREPAGRGAPGHGHAGLPARHAHLPVQGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGRPLSHQDTTVLQGGRQLQEP;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MAEA	Q7L5Y9	152	193	153	193	Alternative sequence	ID=VSP_024786;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9763581;Dbxref=PMID:14702039,PMID:9763581
MAEA	Q7L5Y9	84	152	101	101	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAEA	Q7L5Y9	84	152	123	123	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARVELD2	Q8N4S9	382	394	1	558	Chain	ID=PRO_0000271526;Note=MARVEL domain-containing protein 2
MARVELD2	Q8N4S9	382	394	363	558	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MARVELD2	Q8N4S9	382	394	387	387	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MARVELD2	Q8N4S9	382	394	383	394	Alternative sequence	ID=VSP_035760;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17186462;Dbxref=PMID:17186462
MALL	Q13021	91	133	1	153	Chain	ID=PRO_0000156811;Note=MAL-like protein
MALL	Q13021	91	133	97	117	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MALL	Q13021	91	133	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MALL	Q13021	91	133	22	153	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
MALT1	Q9UDY8	308	319	2	824	Chain	ID=PRO_0000072821;Note=Mucosa-associated lymphoid tissue lymphoma translocation protein 1
MALT1	Q9UDY8	534	584	2	824	Chain	ID=PRO_0000072821;Note=Mucosa-associated lymphoid tissue lymphoma translocation protein 1
MALT1	Q9UDY8	534	584	348	562	Region	Note=Caspase-like
MALT1	Q9UDY8	308	319	309	319	Alternative sequence	ID=VSP_000844;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10523859,ECO:0000303|PubMed:15489334;Dbxref=PMID:10523859,PMID:15489334
MALT1	Q9UDY8	308	319	304	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BFO
MALT1	Q9UDY8	534	584	525	536	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UOA
MALT1	Q9UDY8	534	584	540	545	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UOA
MALT1	Q9UDY8	534	584	549	552	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UOA
MALT1	Q9UDY8	534	584	571	573	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V55
MALT1	Q9UDY8	534	584	574	582	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V55
MAMLD1	Q13495	32	57	1	774	Chain	ID=PRO_0000089592;Note=Mastermind-like domain-containing protein 1
MAMLD1	Q13495	639	680	1	774	Chain	ID=PRO_0000089592;Note=Mastermind-like domain-containing protein 1
MAMLD1	Q13495	32	57	1	774	Chain	ID=PRO_0000089592;Note=Mastermind-like domain-containing protein 1
MAMLD1	Q13495	639	680	1	774	Chain	ID=PRO_0000089592;Note=Mastermind-like domain-containing protein 1
MAMLD1	Q13495	639	680	676	676	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
MAMLD1	Q13495	639	680	676	676	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
MAMLD1	Q13495	32	57	33	57	Alternative sequence	ID=VSP_037654;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MAMLD1	Q13495	32	57	33	57	Alternative sequence	ID=VSP_037654;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MAMLD1	Q13495	639	680	640	774	Alternative sequence	ID=VSP_037655;Note=In isoform 2. GCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP->QEEQRSGLMAMTPERQNAYISQQMSPFEAVQEQVTSKCSRIKASPPSSKHLMPPRTGLLQNNLSPGMIPLTRHQSCEGMGVISPTLGKRQGIFTSSPQCPILSHSGQTPLGRLDSVCQHMQSPKATPPEVPLPGFCPSSLGTQSLSPHQLRRPSVPRMPTAFNNAAWVTAAAAVTTAVSGKTPLSQVDNSVQQHSPSGQACLQRPSDWEAQVPAAMGTQVPLANNPSFSLLGSQSLRQSPVQGPVPVANTTKFLQQGMASFSPLSPIQGIEPPSYVAAAATAAAASAVAASQFPGPFDRTDIPPELPPADFLRQPQPPLNDLISSPDCNEVDFIEALLKGSCVSPDEDWVCNLRLIDDILEQHAAAQNATAQNSGQVTQDAGAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAMLD1	Q13495	639	680	640	774	Alternative sequence	ID=VSP_037655;Note=In isoform 2. GCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP->QEEQRSGLMAMTPERQNAYISQQMSPFEAVQEQVTSKCSRIKASPPSSKHLMPPRTGLLQNNLSPGMIPLTRHQSCEGMGVISPTLGKRQGIFTSSPQCPILSHSGQTPLGRLDSVCQHMQSPKATPPEVPLPGFCPSSLGTQSLSPHQLRRPSVPRMPTAFNNAAWVTAAAAVTTAVSGKTPLSQVDNSVQQHSPSGQACLQRPSDWEAQVPAAMGTQVPLANNPSFSLLGSQSLRQSPVQGPVPVANTTKFLQQGMASFSPLSPIQGIEPPSYVAAAATAAAASAVAASQFPGPFDRTDIPPELPPADFLRQPQPPLNDLISSPDCNEVDFIEALLKGSCVSPDEDWVCNLRLIDDILEQHAAAQNATAQNSGQVTQDAGAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAMLD1	Q13495	639	680	662	662	Natural variant	ID=VAR_020273;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17086185;Dbxref=dbSNP:rs2073043,PMID:17086185
MAMLD1	Q13495	639	680	662	662	Natural variant	ID=VAR_020273;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17086185;Dbxref=dbSNP:rs2073043,PMID:17086185
MAMLD1	Q13495	639	680	640	640	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAMLD1	Q13495	639	680	640	640	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MANBA	O00462	568	623	18	879	Chain	ID=PRO_0000012166;Note=Beta-mannosidase
MANBA	O00462	495	568	18	879	Chain	ID=PRO_0000012166;Note=Beta-mannosidase
MANBA	O00462	410	439	18	879	Chain	ID=PRO_0000012166;Note=Beta-mannosidase
MANBA	O00462	126	183	18	879	Chain	ID=PRO_0000012166;Note=Beta-mannosidase
MAPRE1	Q15691	199	250	2	268	Chain	ID=PRO_0000213416;Note=Microtubule-associated protein RP/EB family member 1
MAPRE1	Q15691	199	250	185	255	Domain	Note=EB1 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00576
MAPRE1	Q15691	199	250	124	268	Region	Note=Interaction with MTUS2/TIP150;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19543227;Dbxref=PMID:19543227
MAPRE1	Q15691	199	250	185	268	Region	Note=Interaction with CDK5RAP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19553473;Dbxref=PMID:19553473
MAPRE1	Q15691	199	250	208	268	Region	Note=DCTN1-binding
MAPRE1	Q15691	199	250	220	242	Region	Note=APC-binding
MAPRE1	Q15691	199	250	192	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WU9
MAPRE1	Q15691	199	250	231	233	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WU9
MAPRE1	Q15691	199	250	237	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WU9
MARCH8	Q5T0T0	34	51	1	291	Chain	ID=PRO_0000274370;Note=E3 ubiquitin-protein ligase MARCH8
MARK1	Q9P0L2	119	141	1	795	Chain	ID=PRO_0000086298;Note=Serine/threonine-protein kinase MARK1
MARK1	Q9P0L2	663	677	1	795	Chain	ID=PRO_0000086298;Note=Serine/threonine-protein kinase MARK1
MARK1	Q9P0L2	119	141	60	311	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MARK1	Q9P0L2	663	677	666	666	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VHJ5
MARK1	Q9P0L2	119	141	1	135	Alternative sequence	ID=VSP_051702;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MARK1	Q9P0L2	119	141	120	141	Alternative sequence	ID=VSP_051703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
MARK1	Q9P0L2	663	677	663	677	Alternative sequence	ID=VSP_051704;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10819331,ECO:0000303|PubMed:14702039;Dbxref=PMID:10819331,PMID:14702039
MARK1	Q9P0L2	119	141	122	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HAK
MARK1	Q9P0L2	119	141	129	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HAK
MARK4	Q96L34	17	84	1	752	Chain	ID=PRO_0000086307;Note=MAP/microtubule affinity-regulating kinase 4
MARK4	Q96L34	262	302	1	752	Chain	ID=PRO_0000086307;Note=MAP/microtubule affinity-regulating kinase 4
MARK4	Q96L34	17	84	59	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MARK4	Q96L34	262	302	59	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MARK4	Q96L34	17	84	65	73	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MARK4	Q96L34	17	84	70	70	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARK4	Q96L34	17	84	70	70	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARK4	Q96L34	17	84	59	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	17	84	69	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	17	84	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	17	84	84	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	262	302	261	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	262	302	281	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	262	302	295	297	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARK4	Q96L34	262	302	301	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ES1
MARCH7	Q9H992	115	171	1	704	Chain	ID=PRO_0000274415;Note=E3 ubiquitin-protein ligase MARCH7
MARCH7	Q9H992	115	171	1	704	Chain	ID=PRO_0000274415;Note=E3 ubiquitin-protein ligase MARCH7
MARCH7	Q9H992	115	171	13	421	Compositional bias	Note=Ser-rich
MARCH7	Q9H992	115	171	13	421	Compositional bias	Note=Ser-rich
MBD5	Q9P267	1018	1421	1	1494	Chain	ID=PRO_0000096266;Note=Methyl-CpG-binding domain protein 5
MBD5	Q9P267	1018	1421	1385	1447	Domain	Note=PWWP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00162
MBD5	Q9P267	1018	1421	852	1494	Alternative sequence	ID=VSP_011084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MBD5	Q9P267	1018	1421	1048	1048	Natural variant	ID=VAR_037567;Note=In MRD1%3B unknown pathological significance. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17847001;Dbxref=dbSNP:rs145475623,PMID:17847001
MBD5	Q9P267	1018	1421	1399	1400	Mutagenesis	Note=Shows diffuse nuclear pattern. WP->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20700456;Dbxref=PMID:20700456
MBD5	Q9P267	1018	1421	1020	1020	Sequence conflict	Note=R->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
MBD5	Q9P267	1018	1421	1020	1020	Sequence conflict	Note=R->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
MBNL2	Q5VZF2	58	113	1	373	Chain	ID=PRO_0000274872;Note=Muscleblind-like protein 2
MBNL2	Q5VZF2	180	268	1	373	Chain	ID=PRO_0000274872;Note=Muscleblind-like protein 2
MBNL2	Q5VZF2	319	331	1	373	Chain	ID=PRO_0000274872;Note=Muscleblind-like protein 2
MBNL2	Q5VZF2	58	113	47	73	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL2	Q5VZF2	180	268	176	204	Zinc finger	Note=C3H1-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL2	Q5VZF2	180	268	212	238	Zinc finger	Note=C3H1-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
MBNL2	Q5VZF2	319	331	320	331	Alternative sequence	ID=VSP_022888;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:15489334,PMID:17974005
MBNL2	Q5VZF2	180	268	254	254	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MBNL2	Q5VZF2	58	113	54	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPP
MBNL2	Q5VZF2	58	113	73	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPP
MBNL2	Q5VZF2	180	268	176	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	184	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	193	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	210	212	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	219	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBNL2	Q5VZF2	180	268	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5S
MBOAT2	Q6ZWT7	100	131	1	520	Chain	ID=PRO_0000273020;Note=Lysophospholipid acyltransferase 2
MBOAT2	Q6ZWT7	74	99	1	520	Chain	ID=PRO_0000273020;Note=Lysophospholipid acyltransferase 2
MBOAT2	Q6ZWT7	74	99	61	81	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MBOAT2	Q6ZWT7	100	131	88	108	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MBOAT2	Q6ZWT7	74	99	88	108	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MDGA1	Q8NFP4	237	327	19	932	Chain	ID=PRO_0000014864;Note=MAM domain-containing glycosylphosphatidylinositol anchor protein 1
MDGA1	Q8NFP4	237	327	240	323	Domain	Note=Ig-like 3
MDGA1	Q8NFP4	237	327	247	247	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
MDGA1	Q8NFP4	237	327	257	257	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MDGA1	Q8NFP4	237	327	307	307	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MDGA1	Q8NFP4	237	327	262	308	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
MDGA1	Q8NFP4	237	327	241	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	248	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	258	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	272	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	292	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	300	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	304	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MDGA1	Q8NFP4	237	327	318	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XEQ
MEGF10	Q96KG7	106	137	26	1140	Chain	ID=PRO_0000309732;Note=Multiple epidermal growth factor-like domains protein 10
MEGF10	Q96KG7	564	613	26	1140	Chain	ID=PRO_0000309732;Note=Multiple epidermal growth factor-like domains protein 10
MEGF10	Q96KG7	106	137	26	1140	Chain	ID=PRO_0000309732;Note=Multiple epidermal growth factor-like domains protein 10
MEGF10	Q96KG7	564	613	26	1140	Chain	ID=PRO_0000309732;Note=Multiple epidermal growth factor-like domains protein 10
MEGF10	Q96KG7	106	137	26	857	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF10	Q96KG7	564	613	26	857	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF10	Q96KG7	106	137	26	857	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF10	Q96KG7	564	613	26	857	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF10	Q96KG7	106	137	30	107	Domain	Note=EMI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00384
MEGF10	Q96KG7	106	137	30	107	Domain	Note=EMI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00384
MEGF10	Q96KG7	106	137	106	136	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF10	Q96KG7	106	137	106	136	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF10	Q96KG7	564	613	539	569	Domain	Note=EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF10	Q96KG7	564	613	539	569	Domain	Note=EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF10	Q96KG7	564	613	577	612	Domain	Note=EGF-like 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF10	Q96KG7	564	613	577	612	Domain	Note=EGF-like 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF10	Q96KG7	106	137	1	857	Region	Note=Necessary for interaction with AP2M1%2C self-assembly and formation of the irregular%2C mosaic-like adhesion pattern;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17643423;Dbxref=PMID:17643423
MEGF10	Q96KG7	564	613	1	857	Region	Note=Necessary for interaction with AP2M1%2C self-assembly and formation of the irregular%2C mosaic-like adhesion pattern;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17643423;Dbxref=PMID:17643423
MEGF10	Q96KG7	106	137	1	857	Region	Note=Necessary for interaction with AP2M1%2C self-assembly and formation of the irregular%2C mosaic-like adhesion pattern;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17643423;Dbxref=PMID:17643423
MEGF10	Q96KG7	564	613	1	857	Region	Note=Necessary for interaction with AP2M1%2C self-assembly and formation of the irregular%2C mosaic-like adhesion pattern;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17643423;Dbxref=PMID:17643423
MEGF10	Q96KG7	106	137	134	134	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF10	Q96KG7	106	137	134	134	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF10	Q96KG7	106	137	109	118	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	106	137	109	118	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	106	137	113	124	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	106	137	113	124	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	106	137	126	135	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	106	137	126	135	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	559	568	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	559	568	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	581	593	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	581	593	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	587	600	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	587	600	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	602	611	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	602	611	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF10	Q96KG7	564	613	566	567	Alternative sequence	ID=VSP_029244;Note=In isoform 2. VH->LF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEGF10	Q96KG7	564	613	566	567	Alternative sequence	ID=VSP_029244;Note=In isoform 2. VH->LF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEGF10	Q96KG7	564	613	568	1140	Alternative sequence	ID=VSP_029245;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEGF10	Q96KG7	564	613	568	1140	Alternative sequence	ID=VSP_029245;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP7D1	Q3KQU3	246	283	1	841	Chain	ID=PRO_0000306807;Note=MAP7 domain-containing protein 1
MAP7D1	Q3KQU3	246	283	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP7D1	Q3KQU3	246	283	273	273	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP7D1	Q3KQU3	246	283	1	454	Alternative sequence	ID=VSP_028483;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP7D1	Q3KQU3	246	283	247	283	Alternative sequence	ID=VSP_028484;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10574461,ECO:0000303|PubMed:11230166;Dbxref=PMID:10574461,PMID:11230166
MADCAM1	Q13477	17	112	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
MADCAM1	Q13477	17	112	19	382	Chain	ID=PRO_0000014853;Note=Mucosal addressin cell adhesion molecule 1
MADCAM1	Q13477	222	309	19	382	Chain	ID=PRO_0000014853;Note=Mucosal addressin cell adhesion molecule 1
MADCAM1	Q13477	222	309	19	382	Chain	ID=PRO_0000014853;Note=Mucosal addressin cell adhesion molecule 1
MADCAM1	Q13477	222	309	19	382	Chain	ID=PRO_0000014853;Note=Mucosal addressin cell adhesion molecule 1
MADCAM1	Q13477	17	112	19	317	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MADCAM1	Q13477	222	309	19	317	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MADCAM1	Q13477	222	309	19	317	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MADCAM1	Q13477	222	309	19	317	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MADCAM1	Q13477	17	112	23	112	Domain	Note=Ig-like 1
MADCAM1	Q13477	222	309	113	231	Domain	Note=Ig-like 2
MADCAM1	Q13477	222	309	113	231	Domain	Note=Ig-like 2
MADCAM1	Q13477	222	309	113	231	Domain	Note=Ig-like 2
MADCAM1	Q13477	222	309	228	231	Repeat	Note=1%3B truncated
MADCAM1	Q13477	222	309	228	231	Repeat	Note=1%3B truncated
MADCAM1	Q13477	222	309	228	231	Repeat	Note=1%3B truncated
MADCAM1	Q13477	222	309	232	239	Repeat	Note=2
MADCAM1	Q13477	222	309	232	239	Repeat	Note=2
MADCAM1	Q13477	222	309	232	239	Repeat	Note=2
MADCAM1	Q13477	222	309	240	247	Repeat	Note=3
MADCAM1	Q13477	222	309	240	247	Repeat	Note=3
MADCAM1	Q13477	222	309	240	247	Repeat	Note=3
MADCAM1	Q13477	222	309	248	255	Repeat	Note=4
MADCAM1	Q13477	222	309	248	255	Repeat	Note=4
MADCAM1	Q13477	222	309	248	255	Repeat	Note=4
MADCAM1	Q13477	222	309	256	263	Repeat	Note=5
MADCAM1	Q13477	222	309	256	263	Repeat	Note=5
MADCAM1	Q13477	222	309	256	263	Repeat	Note=5
MADCAM1	Q13477	222	309	264	271	Repeat	Note=6
MADCAM1	Q13477	222	309	264	271	Repeat	Note=6
MADCAM1	Q13477	222	309	264	271	Repeat	Note=6
MADCAM1	Q13477	222	309	226	317	Region	Note=Mucin-like
MADCAM1	Q13477	222	309	226	317	Region	Note=Mucin-like
MADCAM1	Q13477	222	309	226	317	Region	Note=Mucin-like
MADCAM1	Q13477	222	309	228	271	Region	Note=5.5 X 8 AA tandem repeats of [PS]-P-D-T-T-S-[QP]-E
MADCAM1	Q13477	222	309	228	271	Region	Note=5.5 X 8 AA tandem repeats of [PS]-P-D-T-T-S-[QP]-E
MADCAM1	Q13477	222	309	228	271	Region	Note=5.5 X 8 AA tandem repeats of [PS]-P-D-T-T-S-[QP]-E
MADCAM1	Q13477	17	112	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:23297416;Dbxref=PMID:23297416
MADCAM1	Q13477	17	112	47	94	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1BQS,ECO:0000244|PDB:1GSM,ECO:0000244|PDB:4HBQ,ECO:0000244|PDB:4HC1,ECO:0000244|PDB:4HCR,ECO:0000244|PDB:4HD9,ECO:0000269|PubMed:11807247,ECO:0000269|PubMed:23297416,ECO:0000269|PubMed:9655832;Dbxref=PMID:11807247,PMID:23297416,PMID:9655832
MADCAM1	Q13477	17	112	51	98	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1BQS,ECO:0000244|PDB:1GSM,ECO:0000244|PDB:4HBQ,ECO:0000244|PDB:4HC1,ECO:0000244|PDB:4HCR,ECO:0000244|PDB:4HD9,ECO:0000269|PubMed:11807247,ECO:0000269|PubMed:23297416,ECO:0000269|PubMed:9655832;Dbxref=PMID:11807247,PMID:23297416,PMID:9655832
MADCAM1	Q13477	17	112	18	112	Alternative sequence	ID=VSP_047694;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
MADCAM1	Q13477	222	309	223	334	Alternative sequence	ID=VSP_050014;Note=In isoform 2. VLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLL->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	223	334	Alternative sequence	ID=VSP_050014;Note=In isoform 2. VLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLL->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	223	334	Alternative sequence	ID=VSP_050014;Note=In isoform 2. VLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLL->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	223	310	Alternative sequence	ID=VSP_043202;Note=In isoform 3 and isoform 4. VLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGS->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
MADCAM1	Q13477	222	309	223	310	Alternative sequence	ID=VSP_043202;Note=In isoform 3 and isoform 4. VLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGS->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
MADCAM1	Q13477	222	309	223	310	Alternative sequence	ID=VSP_043202;Note=In isoform 3 and isoform 4. VLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGS->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
MADCAM1	Q13477	222	309	253	253	Natural variant	ID=VAR_047901;Note=S->SPESPDTTSQEPPDTTSQEPPDTTS;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8609404,ECO:0000269|PubMed:9162097;Dbxref=PMID:15489334,PMID:8609404,PMID:9162097
MADCAM1	Q13477	222	309	253	253	Natural variant	ID=VAR_047901;Note=S->SPESPDTTSQEPPDTTSQEPPDTTS;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8609404,ECO:0000269|PubMed:9162097;Dbxref=PMID:15489334,PMID:8609404,PMID:9162097
MADCAM1	Q13477	222	309	253	253	Natural variant	ID=VAR_047901;Note=S->SPESPDTTSQEPPDTTSQEPPDTTS;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8609404,ECO:0000269|PubMed:9162097;Dbxref=PMID:15489334,PMID:8609404,PMID:9162097
MADCAM1	Q13477	222	309	300	300	Natural variant	ID=VAR_017580;Note=P->H;Dbxref=dbSNP:rs3745925
MADCAM1	Q13477	222	309	300	300	Natural variant	ID=VAR_017580;Note=P->H;Dbxref=dbSNP:rs3745925
MADCAM1	Q13477	222	309	300	300	Natural variant	ID=VAR_017580;Note=P->H;Dbxref=dbSNP:rs3745925
MADCAM1	Q13477	222	309	240	240	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	240	240	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	240	240	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	240	240	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	240	240	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	240	240	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	254	254	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	254	254	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	222	309	254	254	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MADCAM1	Q13477	17	112	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	33	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	43	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	52	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BQS
MADCAM1	Q13477	17	112	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	64	67	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	69	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	90	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	17	112	101	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	222	309	213	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	222	309	213	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MADCAM1	Q13477	222	309	213	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HBQ
MAP3K8	P41279	291	342	1	467	Chain	ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8
MAP3K8	P41279	291	342	1	467	Chain	ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8
MAP3K8	P41279	291	342	1	467	Chain	ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8
MAP3K8	P41279	291	342	138	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP3K8	P41279	291	342	138	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP3K8	P41279	291	342	138	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP3K8	P41279	291	342	291	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	291	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	291	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	296	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	307	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	307	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	307	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	326	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	326	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	326	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	340	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	340	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MAP3K8	P41279	291	342	340	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85
MS4A14	Q96JA4	89	106	1	679	Chain	ID=PRO_0000320967;Note=Membrane-spanning 4-domains subfamily A member 14
MS4A14	Q96JA4	89	106	76	96	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A14	Q96JA4	89	106	1	112	Alternative sequence	ID=VSP_031779;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MS4A14	Q96JA4	89	106	90	106	Alternative sequence	ID=VSP_031780;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MBD2	Q9UBB5	234	280	1	411	Chain	ID=PRO_0000096260;Note=Methyl-CpG-binding domain protein 2
MBD2	Q9UBB5	234	280	235	302	Alternative sequence	ID=VSP_011077;Note=In isoform 3. GKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKT->LRWNTHRPAPWHALSRLCLLIRCLLCLECAYPLPLHLVNSYSSKTQLHCLHLWEACPAYSRQNQSFPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9774669;Dbxref=PMID:9774669
MBOAT1	Q6ZNC8	108	139	1	495	Chain	ID=PRO_0000273018;Note=Lysophospholipid acyltransferase 1
MBOAT1	Q6ZNC8	82	107	1	495	Chain	ID=PRO_0000273018;Note=Lysophospholipid acyltransferase 1
MBOAT1	Q6ZNC8	82	107	70	90	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MBOAT1	Q6ZNC8	108	139	126	146	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MBOAT1	Q6ZNC8	108	139	1	158	Alternative sequence	ID=VSP_036729;Note=In isoform 2. MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHD->MEFSLRIFL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MBOAT1	Q6ZNC8	82	107	1	158	Alternative sequence	ID=VSP_036729;Note=In isoform 2. MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHD->MEFSLRIFL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM259	Q4ZIN3	333	361	2	620	Chain	ID=PRO_0000096273;Note=Membralin
TMEM259	Q4ZIN3	239	280	2	620	Chain	ID=PRO_0000096273;Note=Membralin
TMEM259	Q4ZIN3	333	361	346	366	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MYT1L	Q9UL68	492	537	1	1186	Chain	ID=PRO_0000096673;Note=Myelin transcription factor 1-like protein
MYT1L	Q9UL68	168	492	1	1186	Chain	ID=PRO_0000096673;Note=Myelin transcription factor 1-like protein
MYT1L	Q9UL68	492	537	497	540	Zinc finger	Note=CCHHC-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01143
MYT1L	Q9UL68	168	492	97	169	Compositional bias	Note=Asp/Glu-rich
MYT1L	Q9UL68	168	492	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97500
MYT1L	Q9UL68	492	537	1	1004	Alternative sequence	ID=VSP_015722;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYT1L	Q9UL68	168	492	1	1004	Alternative sequence	ID=VSP_015722;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYT1L	Q9UL68	492	537	493	494	Alternative sequence	ID=VSP_015724;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MYT1L	Q9UL68	168	492	191	191	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MBIP	Q9NS73	190	212	1	344	Chain	ID=PRO_0000096269;Note=MAP3K12-binding inhibitory protein 1
MBIP	Q9NS73	190	212	172	344	Region	Note=Interaction with MAP3K12
NR3C2	P08235	671	788	1	984	Chain	ID=PRO_0000053682;Note=Mineralocorticoid receptor
NR3C2	P08235	671	788	1	984	Chain	ID=PRO_0000053682;Note=Mineralocorticoid receptor
NR3C2	P08235	671	788	726	964	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR3C2	P08235	671	788	726	964	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR3C2	P08235	671	788	669	725	Region	Note=Hinge
NR3C2	P08235	671	788	669	725	Region	Note=Hinge
NR3C2	P08235	671	788	782	785	Region	Note=Important for coactivator binding
NR3C2	P08235	671	788	782	785	Region	Note=Important for coactivator binding
NR3C2	P08235	671	788	770	770	Binding site	Note=Steroid
NR3C2	P08235	671	788	770	770	Binding site	Note=Steroid
NR3C2	P08235	671	788	776	776	Binding site	Note=Steroid
NR3C2	P08235	671	788	776	776	Binding site	Note=Steroid
NR3C2	P08235	671	788	672	788	Alternative sequence	ID=VSP_007360;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11518808,ECO:0000303|PubMed:15489334;Dbxref=PMID:11518808,PMID:15489334
NR3C2	P08235	671	788	672	788	Alternative sequence	ID=VSP_007360;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11518808,ECO:0000303|PubMed:15489334;Dbxref=PMID:11518808,PMID:15489334
NR3C2	P08235	671	788	672	706	Alternative sequence	ID=VSP_007358;Note=In isoform 2. ARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEE->ERRCISLPCMNYARGCTKSAFSSFDCSSPLKNTPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11518808;Dbxref=PMID:11518808
NR3C2	P08235	671	788	672	706	Alternative sequence	ID=VSP_007358;Note=In isoform 2. ARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEE->ERRCISLPCMNYARGCTKSAFSSFDCSSPLKNTPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11518808;Dbxref=PMID:11518808
NR3C2	P08235	671	788	707	984	Alternative sequence	ID=VSP_007359;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11518808;Dbxref=PMID:11518808
NR3C2	P08235	671	788	707	984	Alternative sequence	ID=VSP_007359;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11518808;Dbxref=PMID:11518808
NR3C2	P08235	671	788	759	759	Natural variant	ID=VAR_031271;Note=In PHA1A. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16972228;Dbxref=PMID:16972228
NR3C2	P08235	671	788	759	759	Natural variant	ID=VAR_031271;Note=In PHA1A. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16972228;Dbxref=PMID:16972228
NR3C2	P08235	671	788	769	769	Natural variant	ID=VAR_031272;Note=In PHA1A. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16972228;Dbxref=PMID:16972228
NR3C2	P08235	671	788	769	769	Natural variant	ID=VAR_031272;Note=In PHA1A. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16972228;Dbxref=PMID:16972228
NR3C2	P08235	671	788	770	770	Natural variant	ID=VAR_031273;Note=In PHA1A. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16972228;Dbxref=PMID:16972228
NR3C2	P08235	671	788	770	770	Natural variant	ID=VAR_031273;Note=In PHA1A. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16972228;Dbxref=PMID:16972228
NR3C2	P08235	671	788	776	776	Natural variant	ID=VAR_031274;Note=In PHA1A%3B reduces aldosterone binding. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12788847;Dbxref=PMID:12788847
NR3C2	P08235	671	788	776	776	Natural variant	ID=VAR_031274;Note=In PHA1A%3B reduces aldosterone binding. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12788847;Dbxref=PMID:12788847
NR3C2	P08235	671	788	767	767	Mutagenesis	Note=Loss of transcription transactivation. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967794;Dbxref=PMID:15967794
NR3C2	P08235	671	788	767	767	Mutagenesis	Note=Loss of transcription transactivation. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967794;Dbxref=PMID:15967794
NR3C2	P08235	671	788	767	767	Mutagenesis	Note=Strong decrease of transcription transactivation. S->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967794;Dbxref=PMID:15967794
NR3C2	P08235	671	788	767	767	Mutagenesis	Note=Strong decrease of transcription transactivation. S->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967794;Dbxref=PMID:15967794
NR3C2	P08235	671	788	770	770	Mutagenesis	Note=Abolishes aldosterone binding and transcription transactivation. N->A%2CD%2CH%2CQ%2CS%2CT;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10760050,ECO:0000269|PubMed:15967794;Dbxref=PMID:10760050,PMID:15967794
NR3C2	P08235	671	788	770	770	Mutagenesis	Note=Abolishes aldosterone binding and transcription transactivation. N->A%2CD%2CH%2CQ%2CS%2CT;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10760050,ECO:0000269|PubMed:15967794;Dbxref=PMID:10760050,PMID:15967794
NR3C2	P08235	671	788	776	776	Mutagenesis	Note=Reduces aldosterone binding and transcription transactivation. Q->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10760050,ECO:0000269|PubMed:15908963;Dbxref=PMID:10760050,PMID:15908963
NR3C2	P08235	671	788	776	776	Mutagenesis	Note=Reduces aldosterone binding and transcription transactivation. Q->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10760050,ECO:0000269|PubMed:15908963;Dbxref=PMID:10760050,PMID:15908963
NR3C2	P08235	671	788	782	782	Mutagenesis	Note=Decreased coactivator binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16061183;Dbxref=PMID:16061183
NR3C2	P08235	671	788	782	782	Mutagenesis	Note=Decreased coactivator binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16061183;Dbxref=PMID:16061183
NR3C2	P08235	671	788	785	785	Mutagenesis	Note=Loss of coactivator binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16061183;Dbxref=PMID:16061183
NR3C2	P08235	671	788	785	785	Mutagenesis	Note=Loss of coactivator binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16061183;Dbxref=PMID:16061183
NR3C2	P08235	671	788	728	733	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHV
NR3C2	P08235	671	788	728	733	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VHV
NR3C2	P08235	671	788	738	745	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF3
NR3C2	P08235	671	788	738	745	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF3
NR3C2	P08235	671	788	762	785	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF3
NR3C2	P08235	671	788	762	785	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF3
MEIS1	O00470	161	210	1	390	Chain	ID=PRO_0000049105;Note=Homeobox protein Meis1
MEIS1	O00470	161	210	194	240	Compositional bias	Note=Ser/Thr-rich
MEIS3	Q99687	331	359	1	375	Chain	ID=PRO_0000049110;Note=Homeobox protein Meis3
MEIS3	Q99687	149	199	1	375	Chain	ID=PRO_0000049110;Note=Homeobox protein Meis3
MEIS3	Q99687	132	149	1	375	Chain	ID=PRO_0000049110;Note=Homeobox protein Meis3
MEIS3	Q99687	149	199	150	166	Alternative sequence	ID=VSP_012892;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEIS3	Q99687	149	199	168	169	Sequence conflict	Note=KM->RP;Ontology_term=ECO:0000305;evidence=ECO:0000305
MEIS3	Q99687	331	359	351	351	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
MEIS3	Q99687	331	359	356	360	Sequence conflict	Note=VRPPG->FRAPA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC24A5	Q71RS6	290	359	30	500	Chain	ID=PRO_0000045753;Note=Sodium/potassium/calcium exchanger 5
SLC24A5	Q71RS6	290	359	217	302	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A5	Q71RS6	290	359	303	323	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A5	Q71RS6	290	359	324	333	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A5	Q71RS6	290	359	334	354	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A5	Q71RS6	290	359	355	368	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	27	584	Chain	ID=PRO_0000045756;Note=Mitochondrial sodium/calcium exchanger protein
SLC8B1	Q6J4K2	175	231	27	584	Chain	ID=PRO_0000045756;Note=Mitochondrial sodium/calcium exchanger protein
SLC8B1	Q6J4K2	175	231	169	189	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	169	189	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	190	200	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	190	200	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	201	221	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	201	221	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	222	226	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	222	226	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	227	247	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	227	247	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC8B1	Q6J4K2	175	231	176	231	Alternative sequence	ID=VSP_016996;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15060069;Dbxref=PMID:15060069
SLC8B1	Q6J4K2	175	231	176	231	Alternative sequence	ID=VSP_016996;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15060069;Dbxref=PMID:15060069
SLC8B1	Q6J4K2	175	231	222	222	Natural variant	ID=VAR_050224;Note=R->C;Dbxref=dbSNP:rs16942745
SLC8B1	Q6J4K2	175	231	222	222	Natural variant	ID=VAR_050224;Note=R->C;Dbxref=dbSNP:rs16942745
DMGDH	Q9UI17	125	180	51	866	Chain	ID=PRO_0000010767;Note=Dimethylglycine dehydrogenase%2C mitochondrial
DMGDH	Q9UI17	92	125	51	866	Chain	ID=PRO_0000010767;Note=Dimethylglycine dehydrogenase%2C mitochondrial
DMGDH	Q9UI17	92	125	87	95	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5L46,ECO:0000269|PubMed:27486859;Dbxref=PMID:27486859
DMGDH	Q9UI17	92	125	114	114	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBT9
DMGDH	Q9UI17	125	180	148	148	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBT9
DMGDH	Q9UI17	125	180	148	148	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBT9
DMGDH	Q9UI17	125	180	168	168	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBT9
DMGDH	Q9UI17	125	180	19	398	Alternative sequence	ID=VSP_056960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DMGDH	Q9UI17	92	125	19	398	Alternative sequence	ID=VSP_056960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DMGDH	Q9UI17	92	125	109	109	Natural variant	ID=VAR_011505;Note=In DMGDHD%3B shows 10 fold lower catalytic efficiency due to lower cofactor saturation and reduced thermal stability. H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11231903,ECO:0000269|PubMed:27486859;Dbxref=dbSNP:rs121908331,PMID:11231903,PMID:27486859
DMGDH	Q9UI17	92	125	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
DMGDH	Q9UI17	92	125	105	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
DMGDH	Q9UI17	125	180	134	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
DMGDH	Q9UI17	125	180	141	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
DMGDH	Q9UI17	125	180	157	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
DMGDH	Q9UI17	125	180	162	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
DMGDH	Q9UI17	125	180	166	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L46
MAGED1	Q9Y5V3	251	474	1	778	Chain	ID=PRO_0000156723;Note=Melanoma-associated antigen D1
MAGED1	Q9Y5V3	594	614	1	778	Chain	ID=PRO_0000156723;Note=Melanoma-associated antigen D1
MAGED1	Q9Y5V3	251	474	1	778	Chain	ID=PRO_0000156723;Note=Melanoma-associated antigen D1
MAGED1	Q9Y5V3	594	614	1	778	Chain	ID=PRO_0000156723;Note=Melanoma-associated antigen D1
MAGED1	Q9Y5V3	251	474	1	778	Chain	ID=PRO_0000156723;Note=Melanoma-associated antigen D1
MAGED1	Q9Y5V3	594	614	1	778	Chain	ID=PRO_0000156723;Note=Melanoma-associated antigen D1
MAGED1	Q9Y5V3	251	474	296	301	Repeat	Note=1
MAGED1	Q9Y5V3	251	474	296	301	Repeat	Note=1
MAGED1	Q9Y5V3	251	474	296	301	Repeat	Note=1
MAGED1	Q9Y5V3	251	474	302	307	Repeat	Note=2
MAGED1	Q9Y5V3	251	474	302	307	Repeat	Note=2
MAGED1	Q9Y5V3	251	474	302	307	Repeat	Note=2
MAGED1	Q9Y5V3	251	474	308	313	Repeat	Note=3
MAGED1	Q9Y5V3	251	474	308	313	Repeat	Note=3
MAGED1	Q9Y5V3	251	474	308	313	Repeat	Note=3
MAGED1	Q9Y5V3	251	474	332	337	Repeat	Note=4
MAGED1	Q9Y5V3	251	474	332	337	Repeat	Note=4
MAGED1	Q9Y5V3	251	474	332	337	Repeat	Note=4
MAGED1	Q9Y5V3	251	474	338	343	Repeat	Note=5
MAGED1	Q9Y5V3	251	474	338	343	Repeat	Note=5
MAGED1	Q9Y5V3	251	474	338	343	Repeat	Note=5
MAGED1	Q9Y5V3	251	474	344	349	Repeat	Note=6
MAGED1	Q9Y5V3	251	474	344	349	Repeat	Note=6
MAGED1	Q9Y5V3	251	474	344	349	Repeat	Note=6
MAGED1	Q9Y5V3	251	474	350	355	Repeat	Note=7
MAGED1	Q9Y5V3	251	474	350	355	Repeat	Note=7
MAGED1	Q9Y5V3	251	474	350	355	Repeat	Note=7
MAGED1	Q9Y5V3	251	474	356	361	Repeat	Note=8
MAGED1	Q9Y5V3	251	474	356	361	Repeat	Note=8
MAGED1	Q9Y5V3	251	474	356	361	Repeat	Note=8
MAGED1	Q9Y5V3	251	474	362	367	Repeat	Note=9
MAGED1	Q9Y5V3	251	474	362	367	Repeat	Note=9
MAGED1	Q9Y5V3	251	474	362	367	Repeat	Note=9
MAGED1	Q9Y5V3	251	474	368	373	Repeat	Note=10
MAGED1	Q9Y5V3	251	474	368	373	Repeat	Note=10
MAGED1	Q9Y5V3	251	474	368	373	Repeat	Note=10
MAGED1	Q9Y5V3	251	474	374	379	Repeat	Note=11
MAGED1	Q9Y5V3	251	474	374	379	Repeat	Note=11
MAGED1	Q9Y5V3	251	474	374	379	Repeat	Note=11
MAGED1	Q9Y5V3	251	474	380	385	Repeat	Note=12
MAGED1	Q9Y5V3	251	474	380	385	Repeat	Note=12
MAGED1	Q9Y5V3	251	474	380	385	Repeat	Note=12
MAGED1	Q9Y5V3	251	474	386	391	Repeat	Note=13
MAGED1	Q9Y5V3	251	474	386	391	Repeat	Note=13
MAGED1	Q9Y5V3	251	474	386	391	Repeat	Note=13
MAGED1	Q9Y5V3	251	474	392	397	Repeat	Note=14
MAGED1	Q9Y5V3	251	474	392	397	Repeat	Note=14
MAGED1	Q9Y5V3	251	474	392	397	Repeat	Note=14
MAGED1	Q9Y5V3	251	474	398	403	Repeat	Note=15
MAGED1	Q9Y5V3	251	474	398	403	Repeat	Note=15
MAGED1	Q9Y5V3	251	474	398	403	Repeat	Note=15
MAGED1	Q9Y5V3	251	474	404	409	Repeat	Note=16
MAGED1	Q9Y5V3	251	474	404	409	Repeat	Note=16
MAGED1	Q9Y5V3	251	474	404	409	Repeat	Note=16
MAGED1	Q9Y5V3	251	474	410	415	Repeat	Note=17
MAGED1	Q9Y5V3	251	474	410	415	Repeat	Note=17
MAGED1	Q9Y5V3	251	474	410	415	Repeat	Note=17
MAGED1	Q9Y5V3	251	474	416	421	Repeat	Note=18
MAGED1	Q9Y5V3	251	474	416	421	Repeat	Note=18
MAGED1	Q9Y5V3	251	474	416	421	Repeat	Note=18
MAGED1	Q9Y5V3	251	474	422	427	Repeat	Note=19
MAGED1	Q9Y5V3	251	474	422	427	Repeat	Note=19
MAGED1	Q9Y5V3	251	474	422	427	Repeat	Note=19
MAGED1	Q9Y5V3	251	474	428	432	Repeat	Note=20%3B approximate
MAGED1	Q9Y5V3	251	474	428	432	Repeat	Note=20%3B approximate
MAGED1	Q9Y5V3	251	474	428	432	Repeat	Note=20%3B approximate
MAGED1	Q9Y5V3	251	474	433	438	Repeat	Note=21
MAGED1	Q9Y5V3	251	474	433	438	Repeat	Note=21
MAGED1	Q9Y5V3	251	474	433	438	Repeat	Note=21
MAGED1	Q9Y5V3	251	474	439	444	Repeat	Note=22
MAGED1	Q9Y5V3	251	474	439	444	Repeat	Note=22
MAGED1	Q9Y5V3	251	474	439	444	Repeat	Note=22
MAGED1	Q9Y5V3	251	474	471	669	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
MAGED1	Q9Y5V3	594	614	471	669	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
MAGED1	Q9Y5V3	251	474	471	669	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
MAGED1	Q9Y5V3	594	614	471	669	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
MAGED1	Q9Y5V3	251	474	471	669	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
MAGED1	Q9Y5V3	594	614	471	669	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
MAGED1	Q9Y5V3	251	474	296	444	Region	Note=22 X 6 AA tandem repeats of W-[PQ]-X-P-X-X
MAGED1	Q9Y5V3	251	474	296	444	Region	Note=22 X 6 AA tandem repeats of W-[PQ]-X-P-X-X
MAGED1	Q9Y5V3	251	474	296	444	Region	Note=22 X 6 AA tandem repeats of W-[PQ]-X-P-X-X
MAGED1	Q9Y5V3	251	474	279	452	Compositional bias	Note=Pro-rich
MAGED1	Q9Y5V3	251	474	279	452	Compositional bias	Note=Pro-rich
MAGED1	Q9Y5V3	251	474	279	452	Compositional bias	Note=Pro-rich
MAGED2	Q9UNF1	15	179	2	606	Chain	ID=PRO_0000156727;Note=Melanoma-associated antigen D2
MAGED2	Q9UNF1	15	179	2	606	Chain	ID=PRO_0000156727;Note=Melanoma-associated antigen D2
MAGED2	Q9UNF1	15	179	2	606	Chain	ID=PRO_0000156727;Note=Melanoma-associated antigen D2
MAGED2	Q9UNF1	15	179	2	606	Chain	ID=PRO_0000156727;Note=Melanoma-associated antigen D2
MAGED2	Q9UNF1	15	179	2	606	Chain	ID=PRO_0000156727;Note=Melanoma-associated antigen D2
MAGED2	Q9UNF1	15	179	72	72	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAGED2	Q9UNF1	15	179	72	72	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAGED2	Q9UNF1	15	179	72	72	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAGED2	Q9UNF1	15	179	72	72	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAGED2	Q9UNF1	15	179	72	72	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAGED2	Q9UNF1	15	179	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MAGED2	Q9UNF1	15	179	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MAGED2	Q9UNF1	15	179	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MAGED2	Q9UNF1	15	179	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MAGED2	Q9UNF1	15	179	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MAGED2	Q9UNF1	15	179	45	62	Alternative sequence	ID=VSP_008030;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGED2	Q9UNF1	15	179	45	62	Alternative sequence	ID=VSP_008030;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGED2	Q9UNF1	15	179	45	62	Alternative sequence	ID=VSP_008030;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGED2	Q9UNF1	15	179	45	62	Alternative sequence	ID=VSP_008030;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGED2	Q9UNF1	15	179	45	62	Alternative sequence	ID=VSP_008030;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGED2	Q9UNF1	15	179	73	73	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAGED2	Q9UNF1	15	179	73	73	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAGED2	Q9UNF1	15	179	73	73	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAGED2	Q9UNF1	15	179	73	73	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAGED2	Q9UNF1	15	179	73	73	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP3K9	P80192	615	637	1	1104	Chain	ID=PRO_0000086258;Note=Mitogen-activated protein kinase kinase kinase 9
MS4A13	Q5J8X5	62	102	1	152	Chain	ID=PRO_0000315055;Note=Membrane-spanning 4-domains subfamily A member 13
MS4A13	Q5J8X5	62	102	66	86	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A13	Q5J8X5	62	102	44	102	Alternative sequence	ID=VSP_030477;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MS4A13	Q5J8X5	62	102	63	102	Alternative sequence	ID=VSP_030476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MS4A13	Q5J8X5	62	102	102	102	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAML3	Q96JK9	693	777	1	1138	Chain	ID=PRO_0000129496;Note=Mastermind-like protein 3
MAML3	Q96JK9	693	777	467	968	Compositional bias	Note=Gln-rich
MAML3	Q96JK9	693	777	768	768	Natural variant	ID=VAR_046650;Note=Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11347906,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=PMID:11347906,PMID:14702039,PMID:15489334
MAL	P21145	31	87	1	153	Chain	ID=PRO_0000156805;Note=Myelin and lymphocyte protein
MAL	P21145	87	129	1	153	Chain	ID=PRO_0000156805;Note=Myelin and lymphocyte protein
MAL	P21145	31	87	25	46	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	31	87	47	53	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	31	87	54	75	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	31	87	76	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	87	129	76	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	87	129	93	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	87	129	115	125	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	87	129	126	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAL	P21145	31	87	18	151	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
MAL	P21145	87	129	18	151	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
MAL	P21145	31	87	32	129	Alternative sequence	ID=VSP_003162;Note=In isoform D. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAL	P21145	87	129	32	129	Alternative sequence	ID=VSP_003162;Note=In isoform D. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAL	P21145	31	87	32	87	Alternative sequence	ID=VSP_003163;Note=In isoform C. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAL	P21145	87	129	32	87	Alternative sequence	ID=VSP_003163;Note=In isoform C. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAL	P21145	87	129	88	129	Alternative sequence	ID=VSP_003164;Note=In isoform B. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ME3	Q16798	181	235	208	208	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ME3	Q16798	181	235	208	208	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ME3	Q16798	181	235	190	190	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
ME3	Q16798	181	235	190	190	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
ME3	Q16798	339	377	371	371	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06801
ME3	Q16798	339	377	371	371	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06801
ME3	Q16798	339	377	309	342	Alternative sequence	ID=VSP_056626;Note=In isoform 2. ASVAVAGILAALRITKNKLSNHVFVFQGAGEAAM->TCHTFSCPWHLWAQVMFQHIPGPMGFSEWLPRNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ME3	Q16798	339	377	309	342	Alternative sequence	ID=VSP_056626;Note=In isoform 2. ASVAVAGILAALRITKNKLSNHVFVFQGAGEAAM->TCHTFSCPWHLWAQVMFQHIPGPMGFSEWLPRNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ME3	Q16798	518	551	343	604	Alternative sequence	ID=VSP_056627;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ME3	Q16798	339	377	343	604	Alternative sequence	ID=VSP_056627;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ME3	Q16798	518	551	343	604	Alternative sequence	ID=VSP_056627;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ME3	Q16798	339	377	343	604	Alternative sequence	ID=VSP_056627;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
METAP2	P50579	50	86	2	478	Chain	ID=PRO_0000148982;Note=Methionine aminopeptidase 2
METAP2	P50579	86	108	2	478	Chain	ID=PRO_0000148982;Note=Methionine aminopeptidase 2
METAP2	P50579	86	108	98	106	Compositional bias	Note=Poly-Lys
METAP2	P50579	50	86	60	60	Modified residue	Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
METAP2	P50579	50	86	63	63	Modified residue	Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
METAP2	P50579	50	86	74	74	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
METAP2	P50579	50	86	60	60	Glycosylation	Note=O-linked (GlcNAc) serine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250
METAP2	P50579	50	86	63	63	Glycosylation	Note=O-linked (GlcNAc) serine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250
METAP2	P50579	50	86	50	50	Alternative sequence	ID=VSP_055467;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
METAP2	P50579	86	108	87	109	Alternative sequence	ID=VSP_055468;Note=In isoform 2. DGDGDGDGATGKKKKKKKKKRGP->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MARCO	Q9UEW3	141	153	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	189	204	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	204	219	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	219	255	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	300	333	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	369	402	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	402	417	1	520	Chain	ID=PRO_0000181630;Note=Macrophage receptor MARCO
MARCO	Q9UEW3	141	153	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	189	204	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	204	219	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	219	255	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	300	333	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	369	402	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	402	417	65	520	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60754
MARCO	Q9UEW3	141	153	147	419	Domain	Note=Collagen-like
MARCO	Q9UEW3	189	204	147	419	Domain	Note=Collagen-like
MARCO	Q9UEW3	204	219	147	419	Domain	Note=Collagen-like
MARCO	Q9UEW3	219	255	147	419	Domain	Note=Collagen-like
MARCO	Q9UEW3	300	333	147	419	Domain	Note=Collagen-like
MARCO	Q9UEW3	369	402	147	419	Domain	Note=Collagen-like
MARCO	Q9UEW3	402	417	147	419	Domain	Note=Collagen-like
MED24	O75448	874	901	1	989	Chain	ID=PRO_0000065582;Note=Mediator of RNA polymerase II transcription subunit 24
MED24	O75448	312	328	1	989	Chain	ID=PRO_0000065582;Note=Mediator of RNA polymerase II transcription subunit 24
MED24	O75448	71	84	1	989	Chain	ID=PRO_0000065582;Note=Mediator of RNA polymerase II transcription subunit 24
MED24	O75448	71	84	72	84	Alternative sequence	ID=VSP_041125;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MED8	Q96G25	164	247	1	268	Chain	ID=PRO_0000096394;Note=Mediator of RNA polymerase II transcription subunit 8
MED8	Q96G25	90	137	1	268	Chain	ID=PRO_0000096394;Note=Mediator of RNA polymerase II transcription subunit 8
MED8	Q96G25	90	137	133	163	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MEF2C	Q06413	196	212	1	473	Chain	ID=PRO_0000199433;Note=Myocyte-specific enhancer factor 2C
MEF2C	Q06413	86	134	1	473	Chain	ID=PRO_0000199433;Note=Myocyte-specific enhancer factor 2C
MEF2C	Q06413	196	212	1	473	Chain	ID=PRO_0000199433;Note=Myocyte-specific enhancer factor 2C
MEF2C	Q06413	86	134	1	473	Chain	ID=PRO_0000199433;Note=Myocyte-specific enhancer factor 2C
MEF2C	Q06413	86	134	58	86	DNA binding	Note=Mef2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEF2C	Q06413	86	134	58	86	DNA binding	Note=Mef2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEF2C	Q06413	86	134	98	98	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFN5
MEF2C	Q06413	86	134	98	98	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFN5
MEF2C	Q06413	86	134	106	106	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFN5
MEF2C	Q06413	86	134	106	106	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFN5
MEF2C	Q06413	86	134	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFN5
MEF2C	Q06413	86	134	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFN5
MEF2C	Q06413	86	134	116	116	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	116	116	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	87	134	Alternative sequence	ID=VSP_043339;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MEF2C	Q06413	86	134	87	134	Alternative sequence	ID=VSP_043339;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MEF2C	Q06413	86	134	87	134	Alternative sequence	ID=VSP_046251;Note=In isoform 6. TLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLC->ALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MEF2C	Q06413	86	134	87	134	Alternative sequence	ID=VSP_046251;Note=In isoform 6. TLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLC->ALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MEF2C	Q06413	86	134	107	134	Alternative sequence	ID=VSP_045478;Note=In isoform 5. VGHSPESEDKYRKINEDIDLMISRQRLC->ALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MEF2C	Q06413	86	134	107	134	Alternative sequence	ID=VSP_045478;Note=In isoform 5. VGHSPESEDKYRKINEDIDLMISRQRLC->ALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MEF2C	Q06413	86	134	116	116	Mutagenesis	Note=Reduced acetylation. Further reduction in acetylation%3B when associated with R-119. Complete loss of acetylation%2C 15%25 less transactivation activity and slightly reduced DNA binding%3B when associated with R-119%3B R-234%3B R-239%3B R-252 and R-262. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	116	116	Mutagenesis	Note=Reduced acetylation. Further reduction in acetylation%3B when associated with R-119. Complete loss of acetylation%2C 15%25 less transactivation activity and slightly reduced DNA binding%3B when associated with R-119%3B R-234%3B R-239%3B R-252 and R-262. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	119	119	Mutagenesis	Note=Reduced acetylation. Further reduction in acetylation%3B when associated with R-119. Complete loss of acetylation%2C 15%25 less transactivation activity and slightly reduced DNA binding%3B when associated with R-116%3B R-234%3B R-239%3B R-252 and R-262. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2C	Q06413	86	134	119	119	Mutagenesis	Note=Reduced acetylation. Further reduction in acetylation%3B when associated with R-119. Complete loss of acetylation%2C 15%25 less transactivation activity and slightly reduced DNA binding%3B when associated with R-116%3B R-234%3B R-239%3B R-252 and R-262. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15831463;Dbxref=PMID:15831463
MEF2D	Q14814	202	221	1	521	Chain	ID=PRO_0000199435;Note=Myocyte-specific enhancer factor 2D
MEF2D	Q14814	86	132	1	521	Chain	ID=PRO_0000199435;Note=Myocyte-specific enhancer factor 2D
MEF2D	Q14814	86	132	58	86	DNA binding	Note=Mef2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEF2D	Q14814	86	132	98	98	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63943
MEF2D	Q14814	86	132	106	106	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63943
MEF2D	Q14814	86	132	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63943
MEF2D	Q14814	86	132	121	121	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:10617605;Dbxref=PMID:23186163,PMID:10617605
MEF2D	Q14814	86	132	87	132	Alternative sequence	ID=VSP_006251;Note=In isoform MEF2D0B and isoform MEF2D00. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8269842;Dbxref=PMID:8269842
MEF2D	Q14814	86	132	87	132	Alternative sequence	ID=VSP_006250;Note=In isoform MEF2DA'B and isoform MEF2DA'0. TLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRRYG->ALHKKHRECESPEVDEVFALTPQTEEKYKKIDEEFDKMMQSYRLA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8269842;Dbxref=PMID:8269842
METTL17	Q9H7H0	76	121	20	456	Chain	ID=PRO_0000312163;Note=Methyltransferase-like protein 17%2C mitochondrial
LEKR1	Q6ZMV7	152	252	1	388	Chain	ID=PRO_0000325711;Note=Leucine-%2C glutamate- and lysine-rich protein 1
LEKR1	Q6ZMV7	152	252	3	289	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LEKR1	Q6ZMV7	152	252	180	180	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
MSR1	P21757	344	407	1	451	Chain	ID=PRO_0000181627;Note=Macrophage scavenger receptor types I and II
MSR1	P21757	326	344	1	451	Chain	ID=PRO_0000181627;Note=Macrophage scavenger receptor types I and II
MSR1	P21757	34	72	1	451	Chain	ID=PRO_0000181627;Note=Macrophage scavenger receptor types I and II
MSR1	P21757	34	72	1	50	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MSR1	P21757	34	72	51	76	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
MSR1	P21757	344	407	77	451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MSR1	P21757	326	344	77	451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MSR1	P21757	326	344	273	341	Domain	Note=Collagen-like
MSR1	P21757	344	407	350	450	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
MSR1	P21757	344	407	375	439	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:8900177;Dbxref=PMID:8900177
MSR1	P21757	344	407	388	449	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:8900177;Dbxref=PMID:8900177
MSR1	P21757	344	407	345	408	Alternative sequence	ID=VSP_036842;Note=In isoform III. TPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9548586;Dbxref=PMID:9548586
MSR1	P21757	344	407	345	358	Alternative sequence	ID=VSP_006229;Note=In isoform II. TPFTKVRLVGGSGP->RPVQLTDHIRAGPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2251254;Dbxref=PMID:2251254
MSR1	P21757	344	407	359	451	Alternative sequence	ID=VSP_006230;Note=In isoform II. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2251254;Dbxref=PMID:2251254
MSR1	P21757	34	72	36	36	Natural variant	ID=VAR_066581;Note=Found in a family with prostate cancer. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244320;Dbxref=dbSNP:rs749666450,PMID:12244320
MSR1	P21757	34	72	41	41	Natural variant	ID=VAR_066582;Note=Found in patients with prostate cancer. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244320;Dbxref=dbSNP:rs145597376,PMID:12244320
MSR1	P21757	344	407	369	369	Natural variant	ID=VAR_066586;Note=Found in a family with prostate cancer. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244320;Dbxref=dbSNP:rs776370129,PMID:12244320
MTA2	O94776	294	319	1	668	Chain	ID=PRO_0000083496;Note=Metastasis-associated protein MTA2
MTA2	O94776	231	294	1	668	Chain	ID=PRO_0000083496;Note=Metastasis-associated protein MTA2
MTA2	O94776	231	294	145	256	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
MTA2	O94776	294	319	263	315	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
MTA2	O94776	231	294	263	315	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
METTL3	Q86U44	484	506	2	580	Chain	ID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit
METTL3	Q86U44	435	447	2	580	Chain	ID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit
METTL3	Q86U44	435	447	438	438	Binding site	Note=Interaction with METTL14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL3	Q86U44	435	447	441	441	Binding site	Note=Interaction with METTL14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL3	Q86U44	484	506	486	505	Alternative sequence	ID=VSP_007865;Note=In isoform 2. GVKGNPQGFNQGLDCDVIVA->SSSGAQFNRWSTKKNHLISY;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
METTL3	Q86U44	484	506	506	580	Alternative sequence	ID=VSP_007866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
METTL3	Q86U44	435	447	436	446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL3	Q86U44	484	506	480	489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL3	Q86U44	484	506	498	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
KTN1	Q86UP2	321	360	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	360	407	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	572	595	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	832	855	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	898	921	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	1030	1059	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	1059	1089	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	1116	1146	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	1146	1177	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	1177	1201	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	1229	1257	1	1357	Chain	ID=PRO_0000084337;Note=Kinectin
KTN1	Q86UP2	321	360	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	360	407	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	572	595	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	832	855	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	898	921	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1030	1059	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1059	1089	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1116	1146	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1146	1177	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1177	1201	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1229	1257	30	1357	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	321	360	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	360	407	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	572	595	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	832	855	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	898	921	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1030	1059	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1059	1089	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1116	1146	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1146	1177	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1177	1201	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1229	1257	330	1356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1059	1089	1084	1084	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KTN1	Q86UP2	898	921	904	904	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1030	1059	1055	1055	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	1059	1089	1088	1088	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KTN1	Q86UP2	832	855	832	854	Alternative sequence	ID=VSP_043207;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KTN1	Q86UP2	1030	1059	1031	1059	Alternative sequence	ID=VSP_007981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7584026,ECO:0000303|PubMed:8039706;Dbxref=PMID:7584026,PMID:8039706
KTN1	Q86UP2	1059	1089	1031	1059	Alternative sequence	ID=VSP_007981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7584026,ECO:0000303|PubMed:8039706;Dbxref=PMID:7584026,PMID:8039706
KTN1	Q86UP2	1229	1257	1232	1259	Alternative sequence	ID=VSP_007982;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7584026,ECO:0000303|PubMed:8039706;Dbxref=PMID:14702039,PMID:15489334,PMID:7584026,PMID:8039706
KTN1	Q86UP2	1229	1257	1233	1233	Natural variant	ID=VAR_079266;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27932480;Dbxref=dbSNP:rs372815686,PMID:27932480
KTN1	Q86UP2	360	407	373	373	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
L2HGDH	Q9H9P8	355	398	52	463	Chain	ID=PRO_0000228129;Note=L-2-hydroxyglutarate dehydrogenase%2C mitochondrial
L2HGDH	Q9H9P8	136	180	52	463	Chain	ID=PRO_0000228129;Note=L-2-hydroxyglutarate dehydrogenase%2C mitochondrial
L2HGDH	Q9H9P8	355	398	52	463	Chain	ID=PRO_0000228129;Note=L-2-hydroxyglutarate dehydrogenase%2C mitochondrial
L2HGDH	Q9H9P8	136	180	52	463	Chain	ID=PRO_0000228129;Note=L-2-hydroxyglutarate dehydrogenase%2C mitochondrial
L2HGDH	Q9H9P8	136	180	155	155	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
L2HGDH	Q9H9P8	136	180	155	155	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
L2HGDH	Q9H9P8	136	180	173	173	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YP0
L2HGDH	Q9H9P8	136	180	173	173	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YP0
L2HGDH	Q9H9P8	136	180	176	176	Natural variant	ID=VAR_025687;Note=In L2HGA%3B alters protein processing and abolishes catalytic activity. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15548604;Dbxref=PMID:15548604
L2HGDH	Q9H9P8	136	180	176	176	Natural variant	ID=VAR_025687;Note=In L2HGA%3B alters protein processing and abolishes catalytic activity. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15548604;Dbxref=PMID:15548604
L2HGDH	Q9H9P8	136	180	178	178	Natural variant	ID=VAR_025688;Note=Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16134148;Dbxref=dbSNP:rs770542189,PMID:16134148
L2HGDH	Q9H9P8	136	180	178	178	Natural variant	ID=VAR_025688;Note=Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16134148;Dbxref=dbSNP:rs770542189,PMID:16134148
LAG3	P18627	352	433	29	525	Chain	ID=PRO_0000014631;Note=Lymphocyte activation gene 3 protein
LAG3	P18627	352	433	29	450	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAG3	P18627	352	433	348	419	Domain	Note=Ig-like C2-type 3
LAG3	P18627	352	433	369	412	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
LAG3	P18627	352	433	353	360	Alternative sequence	ID=VSP_056311;Note=In isoform 2. VTPKSFGS->GQPQVGKE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAG3	P18627	352	433	361	525	Alternative sequence	ID=VSP_056312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LAMA1	P25391	2484	2542	18	3075	Chain	ID=PRO_0000017054;Note=Laminin subunit alpha-1
LAMA1	P25391	2484	2542	2486	2673	Domain	Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
LAMA1	P25391	2484	2542	2534	2536	Motif	Note=Cell attachment site
LAMA1	P25391	2484	2542	2511	2511	Natural variant	ID=VAR_061347;Note=L->M;Dbxref=dbSNP:rs60009920
LRRC37A	A6NMS7	918	941	36	1700	Chain	ID=PRO_0000337079;Note=Leucine-rich repeat-containing protein 37A
LRRC37A	A6NMS7	1568	1603	36	1700	Chain	ID=PRO_0000337079;Note=Leucine-rich repeat-containing protein 37A
LRRC37A	A6NMS7	918	941	36	1582	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A	A6NMS7	1568	1603	36	1582	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A	A6NMS7	1568	1603	1583	1603	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LRRC37A	A6NMS7	918	941	914	935	Repeat	Note=LRR 3
LRRC37A	A6NMS7	918	941	938	959	Repeat	Note=LRR 4
LAMB3	Q13751	1017	1076	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	786	852	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	124	188	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	1017	1076	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	786	852	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	124	188	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	1017	1076	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	786	852	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	124	188	18	1172	Chain	ID=PRO_0000017071;Note=Laminin subunit beta-3
LAMB3	Q13751	124	188	22	249	Domain	Note=Laminin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00466
LAMB3	Q13751	124	188	22	249	Domain	Note=Laminin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00466
LAMB3	Q13751	124	188	22	249	Domain	Note=Laminin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00466
LAMB3	Q13751	786	852	786	816	Region	Note=Domain alpha
LAMB3	Q13751	786	852	786	816	Region	Note=Domain alpha
LAMB3	Q13751	786	852	786	816	Region	Note=Domain alpha
LAMB3	Q13751	1017	1076	817	1170	Region	Note=Domain I
LAMB3	Q13751	786	852	817	1170	Region	Note=Domain I
LAMB3	Q13751	1017	1076	817	1170	Region	Note=Domain I
LAMB3	Q13751	786	852	817	1170	Region	Note=Domain I
LAMB3	Q13751	1017	1076	817	1170	Region	Note=Domain I
LAMB3	Q13751	786	852	817	1170	Region	Note=Domain I
LAMB3	Q13751	786	852	831	884	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	786	852	831	884	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	786	852	831	884	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	1017	1076	948	1133	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	1017	1076	948	1133	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	1017	1076	948	1133	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	786	852	810	810	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	786	852	810	810	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	786	852	810	810	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
LAMB3	Q13751	124	188	181	181	Natural variant	ID=VAR_037309;Note=N->D;Dbxref=dbSNP:rs2235542
LAMB3	Q13751	124	188	181	181	Natural variant	ID=VAR_037309;Note=N->D;Dbxref=dbSNP:rs2235542
LAMB3	Q13751	124	188	181	181	Natural variant	ID=VAR_037309;Note=N->D;Dbxref=dbSNP:rs2235542
LAMB3	Q13751	786	852	852	852	Natural variant	ID=VAR_034062;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs12748250
LAMB3	Q13751	786	852	852	852	Natural variant	ID=VAR_034062;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs12748250
LAMB3	Q13751	786	852	852	852	Natural variant	ID=VAR_034062;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs12748250
LAMB3	Q13751	124	188	124	124	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMB3	Q13751	124	188	124	124	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMB3	Q13751	124	188	124	124	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMB3	Q13751	786	852	815	815	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMB3	Q13751	786	852	815	815	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
LAMB3	Q13751	786	852	815	815	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMPO	P42167	135	188	1	454	Chain	ID=PRO_0000045841;Note=Lamina-associated polypeptide 2%2C isoforms beta/gamma
TMPO	P42167	221	261	1	454	Chain	ID=PRO_0000045841;Note=Lamina-associated polypeptide 2%2C isoforms beta/gamma
TMPO	P42167	261	293	1	454	Chain	ID=PRO_0000045841;Note=Lamina-associated polypeptide 2%2C isoforms beta/gamma
TMPO	P42167	293	330	1	454	Chain	ID=PRO_0000045841;Note=Lamina-associated polypeptide 2%2C isoforms beta/gamma
TMPO	P42167	135	188	109	153	Domain	Note=LEM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00313
TMPO	P42167	135	188	1	410	Region	Note=Nucleoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPO	P42167	221	261	1	410	Region	Note=Nucleoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPO	P42167	261	293	1	410	Region	Note=Nucleoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPO	P42167	293	330	1	410	Region	Note=Nucleoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPO	P42167	135	188	138	243	Region	Note=NAKAP95-binding N
TMPO	P42167	221	261	138	243	Region	Note=NAKAP95-binding N
TMPO	P42167	293	330	299	371	Region	Note=Binds lamins B
TMPO	P42167	293	330	300	374	Region	Note=NAKAP95-binding C
TMPO	P42167	135	188	154	154	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TMPO	P42167	135	188	156	156	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TMPO	P42167	135	188	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61029
TMPO	P42167	135	188	160	160	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
TMPO	P42167	135	188	164	164	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TMPO	P42167	135	188	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61029
TMPO	P42167	135	188	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMPO	P42167	135	188	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TMPO	P42167	135	188	180	180	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TMPO	P42167	135	188	184	184	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMPO	P42167	221	261	222	222	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMPO	P42167	221	261	224	224	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMPO	P42167	221	261	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMPO	P42167	221	261	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMPO	P42167	261	293	265	265	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TMPO	P42167	261	293	292	292	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TMPO	P42167	293	330	306	306	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:17693683,PMID:17924679,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
TMPO	P42167	293	330	312	312	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TMPO	P42167	293	330	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18220336,PMID:18669648,PMID:20068231,PMID:23186163
TMPO	P42167	293	330	320	320	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPO	P42167	221	261	222	330	Alternative sequence	ID=VSP_004456;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7517549,ECO:0000303|Ref.3;Dbxref=PMID:7517549
TMPO	P42167	261	293	222	330	Alternative sequence	ID=VSP_004456;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7517549,ECO:0000303|Ref.3;Dbxref=PMID:7517549
TMPO	P42167	293	330	222	330	Alternative sequence	ID=VSP_004456;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7517549,ECO:0000303|Ref.3;Dbxref=PMID:7517549
TMPO	P42167	221	261	222	248	Alternative sequence	ID=VSP_056162;Note=In isoform Zeta. SYSQAGITETEWTSGSSKGGPLQALTR->VSLVLLPPCTGINNLLTTLIHVLAFNG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18403046;Dbxref=PMID:18403046
TMPO	P42167	221	261	249	454	Alternative sequence	ID=VSP_056163;Note=In isoform Zeta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18403046;Dbxref=PMID:18403046
TMPO	P42167	261	293	249	454	Alternative sequence	ID=VSP_056163;Note=In isoform Zeta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18403046;Dbxref=PMID:18403046
TMPO	P42167	293	330	249	454	Alternative sequence	ID=VSP_056163;Note=In isoform Zeta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18403046;Dbxref=PMID:18403046
TMPO	P42167	261	293	287	287	Natural variant	ID=VAR_049779;Note=A->P;Dbxref=dbSNP:rs7133258
LDHB	P07195	140	198	2	334	Chain	ID=PRO_0000168459;Note=L-lactate dehydrogenase B chain
LDHB	P07195	140	198	2	334	Chain	ID=PRO_0000168459;Note=L-lactate dehydrogenase B chain
LDHB	P07195	140	198	194	194	Active site	Note=Proton acceptor
LDHB	P07195	140	198	194	194	Active site	Note=Proton acceptor
LDHB	P07195	140	198	170	170	Binding site	Note=Substrate
LDHB	P07195	140	198	170	170	Binding site	Note=Substrate
LDHB	P07195	140	198	171	171	Natural variant	ID=VAR_004176;Note=In LDHBD. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8462975;Dbxref=PMID:8462975
LDHB	P07195	140	198	171	171	Natural variant	ID=VAR_004176;Note=In LDHBD. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8462975;Dbxref=PMID:8462975
LDHB	P07195	140	198	172	172	Natural variant	ID=VAR_004177;Note=In LDHBD. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1587525,ECO:0000269|PubMed:2334429;Dbxref=dbSNP:rs118203895,PMID:1587525,PMID:2334429
LDHB	P07195	140	198	172	172	Natural variant	ID=VAR_004177;Note=In LDHBD. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1587525,ECO:0000269|PubMed:2334429;Dbxref=dbSNP:rs118203895,PMID:1587525,PMID:2334429
LDHB	P07195	140	198	172	172	Natural variant	ID=VAR_011636;Note=In LDHBD. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9929983;Dbxref=PMID:9929983
LDHB	P07195	140	198	172	172	Natural variant	ID=VAR_011636;Note=In LDHBD. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9929983;Dbxref=PMID:9929983
LDHB	P07195	140	198	175	175	Natural variant	ID=VAR_004178;Note=In LDHBD. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8462975;Dbxref=PMID:8462975
LDHB	P07195	140	198	175	175	Natural variant	ID=VAR_004178;Note=In LDHBD. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8462975;Dbxref=PMID:8462975
LDHB	P07195	140	198	175	175	Natural variant	ID=VAR_049758;Note=M->V;Dbxref=dbSNP:rs7966339
LDHB	P07195	140	198	175	175	Natural variant	ID=VAR_049758;Note=M->V;Dbxref=dbSNP:rs7966339
LDHB	P07195	140	198	138	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	138	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	141	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	141	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	183	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	183	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	190	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LDHB	P07195	140	198	190	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I0Z
LETM2	Q2VYF4	167	215	26	491	Chain	ID=PRO_0000307137;Note=LETM1 domain-containing protein LETM2%2C mitochondrial
LETM2	Q2VYF4	368	406	26	491	Chain	ID=PRO_0000307137;Note=LETM1 domain-containing protein LETM2%2C mitochondrial
LETM2	Q2VYF4	406	437	26	491	Chain	ID=PRO_0000307137;Note=LETM1 domain-containing protein LETM2%2C mitochondrial
LETM2	Q2VYF4	167	215	26	177	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
LETM2	Q2VYF4	167	215	178	198	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LETM2	Q2VYF4	167	215	199	491	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
LETM2	Q2VYF4	368	406	199	491	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
LETM2	Q2VYF4	406	437	199	491	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
LETM2	Q2VYF4	368	406	221	438	Domain	Note=Letm1 RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01094
LETM2	Q2VYF4	406	437	221	438	Domain	Note=Letm1 RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01094
LETM2	Q2VYF4	167	215	208	235	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
LETM2	Q2VYF4	368	406	382	385	Compositional bias	Note=Poly-Leu
LETM2	Q2VYF4	167	215	1	214	Alternative sequence	ID=VSP_028588;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LETM2	Q2VYF4	167	215	168	215	Alternative sequence	ID=VSP_028590;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LETM2	Q2VYF4	167	215	215	215	Alternative sequence	ID=VSP_028591;Note=In isoform 4. K->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POR	P16435	122	172	2	677	Chain	ID=PRO_0000167596;Note=NADPH--cytochrome P450 reductase
POR	P16435	244	276	2	677	Chain	ID=PRO_0000167596;Note=NADPH--cytochrome P450 reductase
POR	P16435	416	466	2	677	Chain	ID=PRO_0000167596;Note=NADPH--cytochrome P450 reductase
POR	P16435	122	172	2	677	Chain	ID=PRO_0000167596;Note=NADPH--cytochrome P450 reductase
POR	P16435	244	276	2	677	Chain	ID=PRO_0000167596;Note=NADPH--cytochrome P450 reductase
POR	P16435	416	466	2	677	Chain	ID=PRO_0000167596;Note=NADPH--cytochrome P450 reductase
POR	P16435	122	172	43	677	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	244	276	43	677	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	416	466	43	677	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	122	172	43	677	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	244	276	43	677	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	416	466	43	677	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	122	172	80	224	Domain	Note=Flavodoxin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	122	172	80	224	Domain	Note=Flavodoxin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	416	466	279	521	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	416	466	279	521	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03212
POR	P16435	122	172	138	141	Nucleotide binding	Note=FMN;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03212,ECO:0000269|PubMed:10048323,ECO:0000269|PubMed:21808038;Dbxref=PMID:10048323,PMID:21808038
POR	P16435	122	172	138	141	Nucleotide binding	Note=FMN;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03212,ECO:0000269|PubMed:10048323,ECO:0000269|PubMed:21808038;Dbxref=PMID:10048323,PMID:21808038
POR	P16435	416	466	454	457	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03212,ECO:0000269|PubMed:19483672,ECO:0000269|PubMed:21808038;Dbxref=PMID:19483672,PMID:21808038
POR	P16435	416	466	454	457	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03212,ECO:0000269|PubMed:19483672,ECO:0000269|PubMed:21808038;Dbxref=PMID:19483672,PMID:21808038
POR	P16435	416	466	424	424	Binding site	Note=FAD;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03212,ECO:0000269|PubMed:19483672,ECO:0000269|PubMed:21808038;Dbxref=PMID:19483672,PMID:21808038
POR	P16435	416	466	424	424	Binding site	Note=FAD;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03212,ECO:0000269|PubMed:19483672,ECO:0000269|PubMed:21808038;Dbxref=PMID:19483672,PMID:21808038
POR	P16435	244	276	252	252	Natural variant	ID=VAR_047886;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4
POR	P16435	244	276	252	252	Natural variant	ID=VAR_047886;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4
POR	P16435	416	466	454	454	Natural variant	ID=VAR_021156;Note=In ABS1 and DISPORD%3B significant reduction of activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14758361,ECO:0000269|PubMed:15220035,ECO:0000269|PubMed:15264278,ECO:0000269|PubMed:15483095,ECO:0000269|PubMed:27610946;Dbxref=PMID:14758361,PMID:15220035,PMID:15264278,PMID:15483095,PMID:27610946
POR	P16435	416	466	454	454	Natural variant	ID=VAR_021156;Note=In ABS1 and DISPORD%3B significant reduction of activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14758361,ECO:0000269|PubMed:15220035,ECO:0000269|PubMed:15264278,ECO:0000269|PubMed:15483095,ECO:0000269|PubMed:27610946;Dbxref=PMID:14758361,PMID:15220035,PMID:15264278,PMID:15483095,PMID:27610946
POR	P16435	122	172	119	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	119	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	132	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	132	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	141	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	141	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	150	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	150	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	167	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	122	172	167	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QE2
POR	P16435	244	276	245	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	245	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	259	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	259	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	263	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	263	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	266	270	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	244	276	266	270	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	410	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	410	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	420	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	420	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	427	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	427	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	441	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	441	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	454	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	454	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	462	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
POR	P16435	416	466	462	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFS
METRNL	Q641Q3	185	205	46	311	Chain	ID=PRO_0000289104;Note=Meteorin-like protein
METRNL	Q641Q3	185	205	188	260	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
METRNL	Q641Q3	185	205	191	284	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
METRNL	Q641Q3	185	205	201	306	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
MDH1	P40925	1	34	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|Ref.8;Dbxref=PMID:25944712
MDH1	P40925	1	34	2	334	Chain	ID=PRO_0000113409;Note=Malate dehydrogenase%2C cytoplasmic
MDH1	P40925	125	166	2	334	Chain	ID=PRO_0000113409;Note=Malate dehydrogenase%2C cytoplasmic
MDH1	P40925	225	263	2	334	Chain	ID=PRO_0000113409;Note=Malate dehydrogenase%2C cytoplasmic
MDH1	P40925	1	34	11	17	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
MDH1	P40925	125	166	129	131	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
MDH1	P40925	125	166	131	131	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
MDH1	P40925	125	166	162	162	Binding site	Note=Substrate
MDH1	P40925	1	34	2	2	Modified residue	Note=N-acetylserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|Ref.8;Dbxref=PMID:25944712
MDH1	P40925	225	263	230	230	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14152
MDH1	P40925	225	263	241	241	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
MDH1	P40925	1	34	1	89	Alternative sequence	ID=VSP_042661;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MDH1	P40925	1	34	1	1	Alternative sequence	ID=VSP_045847;Note=In isoform 3. M->MRRCSYFPKDVTVFDKDDK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MDH1	P40925	1	34	15	15	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MED12	Q93074	658	685	1	2177	Chain	ID=PRO_0000096359;Note=Mediator of RNA polymerase II transcription subunit 12
MED12	Q93074	790	807	1	2177	Chain	ID=PRO_0000096359;Note=Mediator of RNA polymerase II transcription subunit 12
MED12	Q93074	1349	1373	1	2177	Chain	ID=PRO_0000096359;Note=Mediator of RNA polymerase II transcription subunit 12
MED12	Q93074	658	685	665	665	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SLC24A4	Q8NFF2	228	245	39	622	Chain	ID=PRO_0000019373;Note=Sodium/potassium/calcium exchanger 4
SLC24A4	Q8NFF2	228	245	225	245	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF8	Q7Z7M0	117	186	28	2845	Chain	ID=PRO_0000055629;Note=Multiple epidermal growth factor-like domains protein 8
MEGF8	Q7Z7M0	699	766	28	2845	Chain	ID=PRO_0000055629;Note=Multiple epidermal growth factor-like domains protein 8
MEGF8	Q7Z7M0	766	833	28	2845	Chain	ID=PRO_0000055629;Note=Multiple epidermal growth factor-like domains protein 8
MEGF8	Q7Z7M0	833	912	28	2845	Chain	ID=PRO_0000055629;Note=Multiple epidermal growth factor-like domains protein 8
MEGF8	Q7Z7M0	1725	1781	28	2845	Chain	ID=PRO_0000055629;Note=Multiple epidermal growth factor-like domains protein 8
MEGF8	Q7Z7M0	117	186	28	2647	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF8	Q7Z7M0	699	766	28	2647	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF8	Q7Z7M0	766	833	28	2647	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF8	Q7Z7M0	833	912	28	2647	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF8	Q7Z7M0	1725	1781	28	2647	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF8	Q7Z7M0	117	186	30	140	Domain	Note=CUB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
MEGF8	Q7Z7M0	117	186	138	168	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF8	Q7Z7M0	117	186	170	203	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MEGF8	Q7Z7M0	833	912	847	899	Domain	Note=PSI 2
MEGF8	Q7Z7M0	833	912	900	947	Domain	Note=PSI 3
MEGF8	Q7Z7M0	1725	1781	1685	1735	Repeat	Note=Kelch 10
MEGF8	Q7Z7M0	117	186	142	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF8	Q7Z7M0	117	186	146	158	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF8	Q7Z7M0	117	186	174	184	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF8	Q7Z7M0	117	186	178	191	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MEGF8	Q7Z7M0	699	766	700	766	Alternative sequence	ID=VSP_036067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9693030;Dbxref=PMID:15489334,PMID:9693030
MEGF8	Q7Z7M0	766	833	700	766	Alternative sequence	ID=VSP_036067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9693030;Dbxref=PMID:15489334,PMID:9693030
MEGF9	Q9H1U4	314	362	31	602	Chain	ID=PRO_0000007526;Note=Multiple epidermal growth factor-like domains protein 9
MEGF9	Q9H1U4	314	362	31	514	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MEGF9	Q9H1U4	314	362	301	348	Domain	Note=Laminin EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEGF9	Q9H1U4	314	362	349	399	Domain	Note=Laminin EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEGF9	Q9H1U4	314	362	303	317	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEGF9	Q9H1U4	314	362	320	329	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEGF9	Q9H1U4	314	362	332	346	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEGF9	Q9H1U4	314	362	349	360	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEGF9	Q9H1U4	314	362	351	371	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
MEI1	Q5TIA1	326	365	1	1274	Chain	ID=PRO_0000347264;Note=Meiosis inhibitor protein 1
MEI1	Q5TIA1	756	848	1	1274	Chain	ID=PRO_0000347264;Note=Meiosis inhibitor protein 1
MEI1	Q5TIA1	903	938	1	1274	Chain	ID=PRO_0000347264;Note=Meiosis inhibitor protein 1
MEI1	Q5TIA1	1178	1222	1	1274	Chain	ID=PRO_0000347264;Note=Meiosis inhibitor protein 1
MEI1	Q5TIA1	326	365	1	992	Alternative sequence	ID=VSP_052883;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10591208,ECO:0000303|PubMed:15489334;Dbxref=PMID:10591208,PMID:15489334
MEI1	Q5TIA1	756	848	1	992	Alternative sequence	ID=VSP_052883;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10591208,ECO:0000303|PubMed:15489334;Dbxref=PMID:10591208,PMID:15489334
MEI1	Q5TIA1	903	938	1	992	Alternative sequence	ID=VSP_052883;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10591208,ECO:0000303|PubMed:15489334;Dbxref=PMID:10591208,PMID:15489334
MEI1	Q5TIA1	326	365	1	757	Alternative sequence	ID=VSP_052884;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MEI1	Q5TIA1	756	848	1	757	Alternative sequence	ID=VSP_052884;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MEI1	Q5TIA1	326	365	1	632	Alternative sequence	ID=VSP_052885;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16683055;Dbxref=PMID:14702039,PMID:16683055
MEI1	Q5TIA1	756	848	445	1274	Alternative sequence	ID=VSP_052886;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEI1	Q5TIA1	903	938	445	1274	Alternative sequence	ID=VSP_052886;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEI1	Q5TIA1	1178	1222	445	1274	Alternative sequence	ID=VSP_052886;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEI1	Q5TIA1	756	848	570	1274	Alternative sequence	ID=VSP_052888;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEI1	Q5TIA1	903	938	570	1274	Alternative sequence	ID=VSP_052888;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEI1	Q5TIA1	1178	1222	570	1274	Alternative sequence	ID=VSP_052888;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MEI1	Q5TIA1	903	938	904	938	Alternative sequence	ID=VSP_052889;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16683055;Dbxref=PMID:16683055
MEI1	Q5TIA1	1178	1222	1179	1222	Alternative sequence	ID=VSP_052890;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10591208,ECO:0000303|PubMed:15489334;Dbxref=PMID:10591208,PMID:15489334
MEI1	Q5TIA1	1178	1222	1193	1222	Alternative sequence	ID=VSP_052891;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCF2L2	Q86YR7	832	904	1	1114	Chain	ID=PRO_0000337087;Note=Probable guanine nucleotide exchange factor MCF2L2
MCF2L2	Q86YR7	767	790	1	1114	Chain	ID=PRO_0000337087;Note=Probable guanine nucleotide exchange factor MCF2L2
MCF2L2	Q86YR7	767	790	619	822	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
MCF2L2	Q86YR7	832	904	834	954	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
MCF2L2	Q86YR7	832	904	629	1114	Alternative sequence	ID=VSP_033873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCF2L2	Q86YR7	767	790	629	1114	Alternative sequence	ID=VSP_033873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCF2L2	Q86YR7	832	904	712	1114	Alternative sequence	ID=VSP_033875;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCF2L2	Q86YR7	767	790	712	1114	Alternative sequence	ID=VSP_033875;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCF2L2	Q86YR7	767	790	772	772	Natural variant	ID=VAR_043594;Note=F->L;Dbxref=dbSNP:rs9826325
MCF2L2	Q86YR7	832	904	902	902	Natural variant	ID=VAR_043595;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10048485,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs6804951,PMID:10048485,PMID:15489334
SLC25A37	Q9NYZ2	146	165	1	338	Chain	ID=PRO_0000235251;Note=Mitoferrin-1
SLC25A37	Q9NYZ2	146	165	143	162	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A37	Q9NYZ2	146	165	141	225	Repeat	Note=Solcar 2
SLC25A37	Q9NYZ2	146	165	1	151	Alternative sequence	ID=VSP_018400;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10931946;Dbxref=PMID:10931946
SLC25A37	Q9NYZ2	146	165	149	155	Alternative sequence	ID=VSP_018402;Note=In isoform 2. AGSMATL->LKAFVWS;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11845285,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.4;Dbxref=PMID:11845285,PMID:15489334,PMID:17974005
SLC25A37	Q9NYZ2	146	165	156	338	Alternative sequence	ID=VSP_018403;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11845285,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.4;Dbxref=PMID:11845285,PMID:15489334,PMID:17974005
MGLL	Q99685	190	262	1	303	Chain	ID=PRO_0000191265;Note=Monoglyceride lipase
MGLL	Q99685	160	190	1	303	Chain	ID=PRO_0000191265;Note=Monoglyceride lipase
MGLL	Q99685	123	160	1	303	Chain	ID=PRO_0000191265;Note=Monoglyceride lipase
MGLL	Q99685	190	262	1	303	Chain	ID=PRO_0000191265;Note=Monoglyceride lipase
MGLL	Q99685	160	190	1	303	Chain	ID=PRO_0000191265;Note=Monoglyceride lipase
MGLL	Q99685	123	160	1	303	Chain	ID=PRO_0000191265;Note=Monoglyceride lipase
MGLL	Q99685	190	262	239	239	Active site	Note=Charge relay system;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19957260;Dbxref=PMID:19957260
MGLL	Q99685	190	262	239	239	Active site	Note=Charge relay system;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19957260;Dbxref=PMID:19957260
MGLL	Q99685	190	262	161	190	Alternative sequence	ID=VSP_045139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MGLL	Q99685	160	190	161	190	Alternative sequence	ID=VSP_045139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MGLL	Q99685	190	262	161	190	Alternative sequence	ID=VSP_045139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MGLL	Q99685	160	190	161	190	Alternative sequence	ID=VSP_045139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MGLL	Q99685	123	160	144	144	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MGLL	Q99685	123	160	144	144	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MGLL	Q99685	123	160	123	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	123	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	136	138	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	136	138	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	140	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	140	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	160	190	153	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	153	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	160	190	153	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	123	160	153	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	160	190	181	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	160	190	181	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	188	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	160	190	188	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	188	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	160	190	188	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUQ
MGLL	Q99685	190	262	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUQ
MGLL	Q99685	190	262	207	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	207	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	224	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	224	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	231	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	231	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	244	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	257	264	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGLL	Q99685	190	262	257	264	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PE6
MGAT5	Q09328	80	135	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	191	215	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	326	370	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	510	559	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	559	598	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	598	623	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	80	135	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	191	215	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	326	370	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	510	559	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	559	598	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	598	623	1	741	Chain	ID=PRO_0000080522;Note=Alpha-1%2C6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
MGAT5	Q09328	80	135	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	191	215	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	326	370	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	510	559	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	559	598	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	598	623	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	191	215	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	326	370	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	510	559	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	559	598	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	598	623	31	741	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	110	110	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	110	110	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	115	115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	115	115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	80	135	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	326	370	334	334	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MGAT5	Q09328	326	370	334	334	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NME4	O00746	75	109	29	187	Chain	ID=PRO_0000019432;Note=Nucleoside diphosphate kinase%2C mitochondrial
NME4	O00746	75	109	93	93	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
NME4	O00746	75	109	90	90	Mutagenesis	Note=Abolishes cardiolipin-containing membrane binding%3B decreases lipid transfer and pro-apoptotic activity%3B does not change phosphotransfer activity. R->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18635542,ECO:0000269|PubMed:23150663;Dbxref=PMID:18635542,PMID:23150663
NME4	O00746	75	109	78	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EHW
NME4	O00746	75	109	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EHW
NME4	O00746	75	109	94	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EHW
NME4	O00746	75	109	106	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EHW
MAN2C1	Q9NTJ4	801	849	1	1040	Chain	ID=PRO_0000206907;Note=Alpha-mannosidase 2C1
MAN2C1	Q9NTJ4	406	438	1	1040	Chain	ID=PRO_0000206907;Note=Alpha-mannosidase 2C1
MAN2C1	Q9NTJ4	336	367	1	1040	Chain	ID=PRO_0000206907;Note=Alpha-mannosidase 2C1
MAN2C1	Q9NTJ4	299	336	1	1040	Chain	ID=PRO_0000206907;Note=Alpha-mannosidase 2C1
MAN2C1	Q9NTJ4	34	75	1	1040	Chain	ID=PRO_0000206907;Note=Alpha-mannosidase 2C1
MAN2C1	Q9NTJ4	299	336	201	299	Alternative sequence	ID=VSP_046395;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MAN2C1	Q9NTJ4	299	336	323	323	Natural variant	ID=VAR_069180;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs200595616,PMID:15489334
MAN2C1	Q9NTJ4	801	849	818	818	Natural variant	ID=VAR_061192;Note=R->H;Dbxref=dbSNP:rs58557444
MAP4K2	Q12851	697	720	1	820	Chain	ID=PRO_0000086275;Note=Mitogen-activated protein kinase kinase kinase kinase 2
MAP4K2	Q12851	177	220	1	820	Chain	ID=PRO_0000086275;Note=Mitogen-activated protein kinase kinase kinase kinase 2
MAP4K2	Q12851	177	220	16	273	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K2	Q12851	697	720	482	793	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MAP3K1	Q13233	562	655	2	1512	Chain	ID=PRO_0000086240;Note=Mitogen-activated protein kinase kinase kinase 1
MAP3K1	Q13233	562	655	616	616	Natural variant	ID=VAR_065507;Note=In SRXY6. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21129722;Dbxref=dbSNP:rs143853590,PMID:21129722
MAP3K6	O95382	324	380	1	1288	Chain	ID=PRO_0000086251;Note=Mitogen-activated protein kinase kinase kinase 6
MAP3K6	O95382	324	380	1	1288	Chain	ID=PRO_0000086251;Note=Mitogen-activated protein kinase kinase kinase 6
MAP4K5	Q9Y4K4	744	775	1	846	Chain	ID=PRO_0000086282;Note=Mitogen-activated protein kinase kinase kinase kinase 5
MAP4K5	Q9Y4K4	126	142	1	846	Chain	ID=PRO_0000086282;Note=Mitogen-activated protein kinase kinase kinase kinase 5
MAP4K5	Q9Y4K4	126	142	20	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAP4K5	Q9Y4K4	744	775	506	819	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
MAP4K5	Q9Y4K4	126	142	140	140	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MXD1	Q05195	58	67	1	221	Chain	ID=PRO_0000127264;Note=Max dimerization protein 1
MXD1	Q05195	58	67	56	108	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
MXD1	Q05195	58	67	58	67	Alternative sequence	ID=VSP_043074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MXD1	Q05195	58	67	58	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NLW
ME2	P23368	81	130	19	584	Chain	ID=PRO_0000018537;Note=NAD-dependent malic enzyme%2C mitochondrial
ME2	P23368	156	210	19	584	Chain	ID=PRO_0000018537;Note=NAD-dependent malic enzyme%2C mitochondrial
ME2	P23368	314	352	19	584	Chain	ID=PRO_0000018537;Note=NAD-dependent malic enzyme%2C mitochondrial
ME2	P23368	156	210	165	173	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10700286,ECO:0000269|PubMed:12962632;Dbxref=PMID:10700286,PMID:12962632
ME2	P23368	314	352	311	328	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10700286,ECO:0000269|PubMed:12962632;Dbxref=PMID:10700286,PMID:12962632
ME2	P23368	81	130	112	112	Active site	Note=Proton donor
ME2	P23368	156	210	183	183	Active site	Note=Proton acceptor
ME2	P23368	81	130	91	91	Binding site	Note=Allosteric activator;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12121650,ECO:0000269|PubMed:12962632;Dbxref=PMID:12121650,PMID:12962632
ME2	P23368	156	210	165	165	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12962632;Dbxref=PMID:12962632
ME2	P23368	156	210	156	156	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ME2	P23368	314	352	346	346	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ME2	P23368	81	130	114	114	Natural variant	ID=VAR_034104;Note=P->L;Dbxref=dbSNP:rs16952692
ME2	P23368	81	130	91	91	Mutagenesis	Note=Abolishes activation by fumarate. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12121650;Dbxref=PMID:12121650
ME2	P23368	81	130	78	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	81	130	93	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	81	130	104	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	81	130	115	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	81	130	123	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	156	210	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	156	210	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	156	210	167	169	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QR6
ME2	P23368	156	210	173	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	156	210	178	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	156	210	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	156	210	198	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	314	352	314	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	314	352	334	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
ME2	P23368	314	352	341	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PJ3
METAP1	P53582	218	262	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
METAP1	P53582	262	310	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
METAP1	P53582	310	332	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
METAP1	P53582	218	262	220	220	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	218	262	231	231	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	218	262	231	231	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	262	310	294	294	Metal binding	Note=Divalent metal cation 2%3B catalytic%3B via tele nitrogen;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	310	332	327	327	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	262	310	301	301	Binding site	Note=Substrate;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	218	262	216	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	218	262	228	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	218	262	243	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	271	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	297	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	310	332	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	310	332	323	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	310	332	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
MAP4	P27816	991	1022	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	953	991	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	835	855	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	702	774	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	625	666	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	217	625	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	217	625	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	217	625	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	176	217	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	138	176	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	97	138	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	74	97	2	1152	Chain	ID=PRO_0000072751;Note=Microtubule-associated protein 4
MAP4	P27816	217	625	248	261	Repeat	Note=1
MAP4	P27816	217	625	248	261	Repeat	Note=1
MAP4	P27816	217	625	248	261	Repeat	Note=1
MAP4	P27816	217	625	262	275	Repeat	Note=2
MAP4	P27816	217	625	262	275	Repeat	Note=2
MAP4	P27816	217	625	262	275	Repeat	Note=2
MAP4	P27816	217	625	276	289	Repeat	Note=3
MAP4	P27816	217	625	276	289	Repeat	Note=3
MAP4	P27816	217	625	276	289	Repeat	Note=3
MAP4	P27816	217	625	290	303	Repeat	Note=4
MAP4	P27816	217	625	290	303	Repeat	Note=4
MAP4	P27816	217	625	290	303	Repeat	Note=4
MAP4	P27816	217	625	304	317	Repeat	Note=5
MAP4	P27816	217	625	304	317	Repeat	Note=5
MAP4	P27816	217	625	304	317	Repeat	Note=5
MAP4	P27816	217	625	318	331	Repeat	Note=6
MAP4	P27816	217	625	318	331	Repeat	Note=6
MAP4	P27816	217	625	318	331	Repeat	Note=6
MAP4	P27816	217	625	332	345	Repeat	Note=7
MAP4	P27816	217	625	332	345	Repeat	Note=7
MAP4	P27816	217	625	332	345	Repeat	Note=7
MAP4	P27816	217	625	346	351	Repeat	Note=8%3B truncated
MAP4	P27816	217	625	346	351	Repeat	Note=8%3B truncated
MAP4	P27816	217	625	346	351	Repeat	Note=8%3B truncated
MAP4	P27816	217	625	352	377	Repeat	Note=26 residues 1
MAP4	P27816	217	625	352	377	Repeat	Note=26 residues 1
MAP4	P27816	217	625	352	377	Repeat	Note=26 residues 1
MAP4	P27816	217	625	378	403	Repeat	Note=26 residues 2
MAP4	P27816	217	625	378	403	Repeat	Note=26 residues 2
MAP4	P27816	217	625	378	403	Repeat	Note=26 residues 2
MAP4	P27816	217	625	408	421	Repeat	Note=9
MAP4	P27816	217	625	408	421	Repeat	Note=9
MAP4	P27816	217	625	408	421	Repeat	Note=9
MAP4	P27816	217	625	422	433	Repeat	Note=10
MAP4	P27816	217	625	422	433	Repeat	Note=10
MAP4	P27816	217	625	422	433	Repeat	Note=10
MAP4	P27816	217	625	434	447	Repeat	Note=11
MAP4	P27816	217	625	434	447	Repeat	Note=11
MAP4	P27816	217	625	434	447	Repeat	Note=11
MAP4	P27816	217	625	448	461	Repeat	Note=12
MAP4	P27816	217	625	448	461	Repeat	Note=12
MAP4	P27816	217	625	448	461	Repeat	Note=12
MAP4	P27816	217	625	462	475	Repeat	Note=13
MAP4	P27816	217	625	462	475	Repeat	Note=13
MAP4	P27816	217	625	462	475	Repeat	Note=13
MAP4	P27816	217	625	476	489	Repeat	Note=14
MAP4	P27816	217	625	476	489	Repeat	Note=14
MAP4	P27816	217	625	476	489	Repeat	Note=14
MAP4	P27816	217	625	490	503	Repeat	Note=15
MAP4	P27816	217	625	490	503	Repeat	Note=15
MAP4	P27816	217	625	490	503	Repeat	Note=15
MAP4	P27816	217	625	504	517	Repeat	Note=16
MAP4	P27816	217	625	504	517	Repeat	Note=16
MAP4	P27816	217	625	504	517	Repeat	Note=16
MAP4	P27816	217	625	532	545	Repeat	Note=17
MAP4	P27816	217	625	532	545	Repeat	Note=17
MAP4	P27816	217	625	532	545	Repeat	Note=17
MAP4	P27816	953	991	923	953	Repeat	Note=Tau/MAP 1
MAP4	P27816	991	1022	992	1022	Repeat	Note=Tau/MAP 2
MAP4	P27816	217	625	248	545	Region	Note=17 X 14 AA tandem repeats
MAP4	P27816	217	625	248	545	Region	Note=17 X 14 AA tandem repeats
MAP4	P27816	217	625	248	545	Region	Note=17 X 14 AA tandem repeats
MAP4	P27816	97	138	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MAP4	P27816	217	625	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27546
MAP4	P27816	217	625	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27546
MAP4	P27816	217	625	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27546
MAP4	P27816	217	625	280	280	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17693683,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	280	280	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17693683,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	280	280	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17693683,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	282	282	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
MAP4	P27816	217	625	282	282	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
MAP4	P27816	217	625	282	282	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
MAP4	P27816	217	625	354	354	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	354	354	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	354	354	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	358	358	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	358	358	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	358	358	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	380	380	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	380	380	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	380	380	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	384	384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	384	384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	384	384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	217	625	440	440	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	217	625	440	440	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	217	625	440	440	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	217	625	442	442	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	217	625	442	442	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	217	625	442	442	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	217	625	507	507	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	507	507	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	507	507	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	510	510	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
MAP4	P27816	217	625	510	510	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
MAP4	P27816	217	625	510	510	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
MAP4	P27816	217	625	521	521	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18088087,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	521	521	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18088087,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	521	521	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18088087,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	526	526	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
MAP4	P27816	217	625	526	526	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
MAP4	P27816	217	625	526	526	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
MAP4	P27816	217	625	571	571	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	571	571	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	571	571	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
MAP4	P27816	217	625	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MAP4	P27816	217	625	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MAP4	P27816	217	625	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
MAP4	P27816	217	625	585	585	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
MAP4	P27816	217	625	585	585	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
MAP4	P27816	217	625	585	585	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
MAP4	P27816	217	625	624	624	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	624	624	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	217	625	624	624	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
MAP4	P27816	625	666	636	636	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
MAP4	P27816	625	666	643	643	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27546
MAP4	P27816	702	774	713	713	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	702	774	723	723	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	835	855	853	853	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MAP4	P27816	991	1022	1000	1000	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
MAP4	P27816	217	625	269	269	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
MAP4	P27816	217	625	269	269	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
MAP4	P27816	217	625	269	269	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
MAP4	P27816	835	855	838	838	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MAP4	P27816	138	176	1	151	Alternative sequence	ID=VSP_032065;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	97	138	1	151	Alternative sequence	ID=VSP_032065;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	74	97	1	151	Alternative sequence	ID=VSP_032065;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	74	97	1	82	Alternative sequence	ID=VSP_032066;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	176	217	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	138	176	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	97	138	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	74	97	83	221	Alternative sequence	ID=VSP_032067;Note=In isoform 4. LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE->METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	97	138	98	99	Alternative sequence	ID=VSP_043240;Note=In isoform 7. GS->EA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	991	1022	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	953	991	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	835	855	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	702	774	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	625	666	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	176	217	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	138	176	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	97	138	100	1152	Alternative sequence	ID=VSP_043241;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	152	437	Alternative sequence	ID=VSP_032068;Note=In isoform 3. LVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVA->MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSIEMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQETSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIRDHDKELEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	152	437	Alternative sequence	ID=VSP_032068;Note=In isoform 3. LVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVA->MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSIEMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQETSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIRDHDKELEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	152	437	Alternative sequence	ID=VSP_032068;Note=In isoform 3. LVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVA->MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSIEMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQETSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIRDHDKELEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	176	217	152	437	Alternative sequence	ID=VSP_032068;Note=In isoform 3. LVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVA->MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSIEMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQETSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIRDHDKELEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	138	176	152	437	Alternative sequence	ID=VSP_032068;Note=In isoform 3. LVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVA->MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSIEMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQETSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIRDHDKELEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	225	271	Alternative sequence	ID=VSP_032069;Note=In isoform 4. EIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTE->NGQEIAPAQISKSLMVDNYTKDGVPGQERPKGPSAVVPSTSTGG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	225	271	Alternative sequence	ID=VSP_032069;Note=In isoform 4. EIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTE->NGQEIAPAQISKSLMVDNYTKDGVPGQERPKGPSAVVPSTSTGG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	225	271	Alternative sequence	ID=VSP_032069;Note=In isoform 4. EIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTE->NGQEIAPAQISKSLMVDNYTKDGVPGQERPKGPSAVVPSTSTGG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	625	666	275	666	Alternative sequence	ID=VSP_032070;Note=In isoform 4. AKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->PITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKGHLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	275	666	Alternative sequence	ID=VSP_032070;Note=In isoform 4. AKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->PITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKGHLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	275	666	Alternative sequence	ID=VSP_032070;Note=In isoform 4. AKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->PITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKGHLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	275	666	Alternative sequence	ID=VSP_032070;Note=In isoform 4. AKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->PITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKGHLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	625	666	322	666	Alternative sequence	ID=VSP_032071;Note=In isoform 5. WPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->LPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MAP4	P27816	217	625	322	666	Alternative sequence	ID=VSP_032071;Note=In isoform 5. WPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->LPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MAP4	P27816	217	625	322	666	Alternative sequence	ID=VSP_032071;Note=In isoform 5. WPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->LPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MAP4	P27816	217	625	322	666	Alternative sequence	ID=VSP_032071;Note=In isoform 5. WPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS->LPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MAP4	P27816	625	666	441	631	Alternative sequence	ID=VSP_032072;Note=In isoform 3. ETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT->TEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVGEEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	441	631	Alternative sequence	ID=VSP_032072;Note=In isoform 3. ETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT->TEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVGEEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	441	631	Alternative sequence	ID=VSP_032072;Note=In isoform 3. ETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT->TEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVGEEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	217	625	441	631	Alternative sequence	ID=VSP_032072;Note=In isoform 3. ETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT->TEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVGEEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	702	774	558	730	Alternative sequence	ID=VSP_003200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	625	666	558	730	Alternative sequence	ID=VSP_003200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	558	730	Alternative sequence	ID=VSP_003200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	558	730	Alternative sequence	ID=VSP_003200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	217	625	558	730	Alternative sequence	ID=VSP_003200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAP4	P27816	625	666	635	666	Alternative sequence	ID=VSP_032073;Note=In isoform 3. CSLPAEEDSVLEKLGERKPCNSQPSELSSETS->EIEVTATQSTPSFLFEKPPRD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	702	774	703	716	Alternative sequence	ID=VSP_032074;Note=In isoform 3. PLATTQPAKTSTSK->VGARMVVIFYCHNF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	991	1022	717	1152	Alternative sequence	ID=VSP_032075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	953	991	717	1152	Alternative sequence	ID=VSP_032075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	835	855	717	1152	Alternative sequence	ID=VSP_032075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	702	774	717	1152	Alternative sequence	ID=VSP_032075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	953	991	939	953	Alternative sequence	ID=VSP_032076;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAP4	P27816	991	1022	954	1022	Alternative sequence	ID=VSP_032077;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MAP4	P27816	953	991	954	1022	Alternative sequence	ID=VSP_032077;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MAP4	P27816	217	625	366	366	Natural variant	ID=VAR_039567;Note=P->L;Dbxref=dbSNP:rs13097415
MAP4	P27816	217	625	366	366	Natural variant	ID=VAR_039567;Note=P->L;Dbxref=dbSNP:rs13097415
MAP4	P27816	217	625	366	366	Natural variant	ID=VAR_039567;Note=P->L;Dbxref=dbSNP:rs13097415
MAP4	P27816	217	625	367	367	Natural variant	ID=VAR_039568;Note=S->P;Dbxref=dbSNP:rs13096947
MAP4	P27816	217	625	367	367	Natural variant	ID=VAR_039568;Note=S->P;Dbxref=dbSNP:rs13096947
MAP4	P27816	217	625	367	367	Natural variant	ID=VAR_039568;Note=S->P;Dbxref=dbSNP:rs13096947
MAP4	P27816	217	625	409	409	Natural variant	ID=VAR_039569;Note=D->G;Dbxref=dbSNP:rs13076542
MAP4	P27816	217	625	409	409	Natural variant	ID=VAR_039569;Note=D->G;Dbxref=dbSNP:rs13076542
MAP4	P27816	217	625	409	409	Natural variant	ID=VAR_039569;Note=D->G;Dbxref=dbSNP:rs13076542
MAP4	P27816	217	625	427	427	Natural variant	ID=VAR_020361;Note=S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1718985;Dbxref=dbSNP:rs1060407,PMID:1718985
MAP4	P27816	217	625	427	427	Natural variant	ID=VAR_020361;Note=S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1718985;Dbxref=dbSNP:rs1060407,PMID:1718985
MAP4	P27816	217	625	427	427	Natural variant	ID=VAR_020361;Note=S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1718985;Dbxref=dbSNP:rs1060407,PMID:1718985
MAP4	P27816	217	625	441	441	Natural variant	ID=VAR_020362;Note=E->Q;Dbxref=dbSNP:rs2230169
MAP4	P27816	217	625	441	441	Natural variant	ID=VAR_020362;Note=E->Q;Dbxref=dbSNP:rs2230169
MAP4	P27816	217	625	441	441	Natural variant	ID=VAR_020362;Note=E->Q;Dbxref=dbSNP:rs2230169
MAP4	P27816	625	666	628	628	Natural variant	ID=VAR_039570;Note=V->I;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000269|PubMed:1718985;Dbxref=dbSNP:rs1137524,PMID:18669648,PMID:20068231,PMID:1718985
MAP4	P27816	991	1022	994	994	Natural variant	ID=VAR_039571;Note=I->V;Dbxref=dbSNP:rs35736893
MAP4	P27816	138	176	160	160	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP4	P27816	217	625	319	319	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP4	P27816	217	625	319	319	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MAP4	P27816	217	625	319	319	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCOA6	Q14686	1964	1987	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	509	558	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	171	214	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	78	130	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	1964	1987	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	509	558	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	171	214	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	78	130	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
NCOA6	Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	509	558	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	171	214	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	78	130	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	509	558	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	171	214	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	78	130	1	1310	Region	Note=NCOA1-binding region
NCOA6	Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	509	558	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	171	214	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	78	130	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	509	558	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	171	214	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	78	130	1	1057	Region	Note=CREBBP-binding region
NCOA6	Q14686	509	558	1	928	Region	Note=TBP/GTF2A-binding region
NCOA6	Q14686	171	214	1	928	Region	Note=TBP/GTF2A-binding region
NCOA6	Q14686	78	130	1	928	Region	Note=TBP/GTF2A-binding region
NCOA6	Q14686	509	558	1	928	Region	Note=TBP/GTF2A-binding region
NCOA6	Q14686	171	214	1	928	Region	Note=TBP/GTF2A-binding region
NCOA6	Q14686	78	130	1	928	Region	Note=TBP/GTF2A-binding region
NCOA6	Q14686	1964	1987	1641	2063	Region	Note=EP300/CRSP3-binding region
NCOA6	Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region
NCOA6	Q14686	1964	1987	1641	2063	Region	Note=EP300/CRSP3-binding region
NCOA6	Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region
NCOA6	Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
NCOA6	Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
NCOA6	Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
NCOA6	Q14686	509	558	227	1041	Compositional bias	Note=Gln-rich
NCOA6	Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
NCOA6	Q14686	509	558	227	1041	Compositional bias	Note=Gln-rich
NCOA6	Q14686	78	130	95	95	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
NCOA6	Q14686	78	130	95	95	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
NCOA6	Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19
NCOA6	Q14686	509	558	512	512	Natural variant	ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031
NCOA6	Q14686	509	558	512	512	Natural variant	ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031
NCOA6	Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NCOA6	Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NCOA6	Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NCOA6	Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MEPCE	Q7L2J0	557	630	1	689	Chain	ID=PRO_0000289262;Note=7SK snRNA methylphosphate capping enzyme
MEPCE	Q7L2J0	557	630	431	686	Domain	Note=Bin3-type SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00848
MEPCE	Q7L2J0	557	630	559	560	Region	Note=S-adenosyl-L-methionine binding
MEPCE	Q7L2J0	557	630	581	581	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen
MEPCE	Q7L2J0	557	630	553	557	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
MEPCE	Q7L2J0	557	630	565	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
MEPCE	Q7L2J0	557	630	575	582	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
MEPCE	Q7L2J0	557	630	584	606	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
MEPCE	Q7L2J0	557	630	607	616	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
MEPCE	Q7L2J0	557	630	620	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
MEPCE	Q7L2J0	557	630	625	628	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UNA
METTL14	Q9HCE5	215	246	1	456	Chain	ID=PRO_0000325790;Note=N6-adenosine-methyltransferase non-catalytic subunit
METTL14	Q9HCE5	215	246	237	238	Region	Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	245	254	Region	Note=Positively charged region required for RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	242	242	Binding site	Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	245	245	Binding site	Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	245	245	Mutagenesis	Note=Reduced RNA-binding. Reduced RNA-binding%3B when associated with E-255. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	213	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL14	Q9HCE5	215	246	221	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL14	Q9HCE5	215	246	225	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL14	Q9HCE5	215	246	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL15	A6NJ78	136	199	1	407	Chain	ID=PRO_0000308332;Note=Probable methyltransferase-like protein 15
METTL15	A6NJ78	136	199	146	146	Binding site	Note=S-adenosyl-L-methionine%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
METTL15	A6NJ78	136	199	169	169	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250
METTL15	A6NJ78	136	199	176	176	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250
METTL15	A6NJ78	136	199	100	407	Alternative sequence	ID=VSP_028971;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
METTL15	A6NJ78	136	199	149	149	Natural variant	ID=VAR_036802;Note=A->T;Dbxref=dbSNP:rs11823114
METTL15	A6NJ78	136	199	191	191	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
METTL15	A6NJ78	136	199	194	194	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MFN2	O95140	236	272	1	757	Chain	ID=PRO_0000127675;Note=Mitofusin-2
MFN2	O95140	572	624	1	757	Chain	ID=PRO_0000127675;Note=Mitofusin-2
MFN2	O95140	236	272	1	757	Chain	ID=PRO_0000127675;Note=Mitofusin-2
MFN2	O95140	572	624	1	757	Chain	ID=PRO_0000127675;Note=Mitofusin-2
MFN2	O95140	236	272	1	604	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN2	O95140	572	624	1	604	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN2	O95140	236	272	1	604	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN2	O95140	572	624	1	604	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN2	O95140	572	624	605	625	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN2	O95140	572	624	605	625	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFN2	O95140	236	272	93	342	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
MFN2	O95140	236	272	93	342	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
MFN2	O95140	236	272	258	261	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8IWA4
MFN2	O95140	236	272	258	261	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8IWA4
MFN2	O95140	236	272	258	261	Region	Note=G4 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
MFN2	O95140	236	272	258	261	Region	Note=G4 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
MFN2	O95140	236	272	1	302	Alternative sequence	ID=VSP_015159;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MFN2	O95140	236	272	1	302	Alternative sequence	ID=VSP_015159;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MFN2	O95140	236	272	251	251	Natural variant	ID=VAR_018610;Note=In CMT2A2A. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15064763;Dbxref=dbSNP:rs28940295,PMID:15064763
MFN2	O95140	236	272	251	251	Natural variant	ID=VAR_018610;Note=In CMT2A2A. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15064763;Dbxref=dbSNP:rs28940295,PMID:15064763
MFN2	O95140	236	272	259	259	Natural variant	ID=VAR_073291;Note=Found in a patient with hereditary motor and sensory neuropathy%3B unknown pathological significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=dbSNP:rs755065651,PMID:24627108
MFN2	O95140	236	272	259	259	Natural variant	ID=VAR_073291;Note=Found in a patient with hereditary motor and sensory neuropathy%3B unknown pathological significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=dbSNP:rs755065651,PMID:24627108
MFN2	O95140	236	272	259	259	Mutagenesis	Note=Loss of function in promoting mitochondrial fusion. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28114303;Dbxref=PMID:28114303
MFN2	O95140	236	272	259	259	Mutagenesis	Note=Loss of function in promoting mitochondrial fusion. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28114303;Dbxref=PMID:28114303
MFN2	O95140	236	272	259	259	Mutagenesis	Note=Does not affect its ability to cluster mitochondria%3B when overexpressed. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11950885;Dbxref=PMID:11950885
MFN2	O95140	236	272	259	259	Mutagenesis	Note=Does not affect its ability to cluster mitochondria%3B when overexpressed. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11950885;Dbxref=PMID:11950885
MFN2	O95140	236	272	260	260	Mutagenesis	Note=Loss of function in promoting mitochondrial fusion. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28114303;Dbxref=PMID:28114303
MFN2	O95140	236	272	260	260	Mutagenesis	Note=Loss of function in promoting mitochondrial fusion. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28114303;Dbxref=PMID:28114303
MFN2	O95140	236	272	266	266	Mutagenesis	Note=Loss of function in promoting mitochondrial fusion. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28114303;Dbxref=PMID:28114303
MFN2	O95140	236	272	266	266	Mutagenesis	Note=Loss of function in promoting mitochondrial fusion. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28114303;Dbxref=PMID:28114303
MFN2	O95140	572	624	622	624	Mutagenesis	Note=Does not affect the targeting to mitochondrial outer membrane. GGV->AAL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11181170;Dbxref=PMID:11181170
MFN2	O95140	572	624	622	624	Mutagenesis	Note=Does not affect the targeting to mitochondrial outer membrane. GGV->AAL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11181170;Dbxref=PMID:11181170
MFN2	O95140	572	624	622	624	Mutagenesis	Note=Abolishes the targeting to mitochondrial outer membrane. GGV->RRE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11181170;Dbxref=PMID:11181170
MFN2	O95140	572	624	622	624	Mutagenesis	Note=Abolishes the targeting to mitochondrial outer membrane. GGV->RRE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11181170;Dbxref=PMID:11181170
MED27	Q6P2C8	241	267	1	311	Chain	ID=PRO_0000079361;Note=Mediator of RNA polymerase II transcription subunit 27
MED27	Q6P2C8	227	241	1	311	Chain	ID=PRO_0000079361;Note=Mediator of RNA polymerase II transcription subunit 27
MED27	Q6P2C8	191	227	1	311	Chain	ID=PRO_0000079361;Note=Mediator of RNA polymerase II transcription subunit 27
MED27	Q6P2C8	241	267	131	311	Alternative sequence	ID=VSP_055412;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8889548;Dbxref=PMID:8889548
MED27	Q6P2C8	227	241	131	311	Alternative sequence	ID=VSP_055412;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8889548;Dbxref=PMID:8889548
MED27	Q6P2C8	191	227	131	311	Alternative sequence	ID=VSP_055412;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8889548;Dbxref=PMID:8889548
MED27	Q6P2C8	227	241	192	227	Alternative sequence	ID=VSP_051869;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15164053,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:15164053,PMID:15489334
MED27	Q6P2C8	191	227	192	227	Alternative sequence	ID=VSP_051869;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15164053,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:15164053,PMID:15489334
MED27	Q6P2C8	191	227	207	207	Sequence conflict	Note=L->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
MED27	Q6P2C8	227	241	235	235	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
MED14	O60244	1044	1088	1	1454	Chain	ID=PRO_0000079357;Note=Mediator of RNA polymerase II transcription subunit 14
MED14	O60244	870	960	1	1454	Chain	ID=PRO_0000079357;Note=Mediator of RNA polymerase II transcription subunit 14
MED14	O60244	819	870	1	1454	Chain	ID=PRO_0000079357;Note=Mediator of RNA polymerase II transcription subunit 14
MED14	O60244	428	470	1	1454	Chain	ID=PRO_0000079357;Note=Mediator of RNA polymerase II transcription subunit 14
MED14	O60244	428	470	188	566	Region	Note=Interaction with STAT2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12509459;Dbxref=PMID:12509459
MED14	O60244	819	870	500	824	Region	Note=Interaction with SREBF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340088;Dbxref=PMID:15340088
MED14	O60244	1044	1088	1002	1165	Compositional bias	Note=Pro-rich
SLC24A2	Q9UI40	359	376	1	661	Chain	ID=PRO_0000019367;Note=Sodium/potassium/calcium exchanger 2
SLC24A2	Q9UI40	359	376	287	497	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC24A2	Q9UI40	359	376	360	376	Alternative sequence	ID=VSP_006164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10662833,ECO:0000303|PubMed:15489334;Dbxref=PMID:10662833,PMID:15489334
METTL2B	Q6P1Q9	305	327	2	378	Chain	ID=PRO_0000328847;Note=Methyltransferase-like protein 2B
MAT1A	Q00266	56	97	1	395	Chain	ID=PRO_0000174432;Note=S-adenosylmethionine synthase isoform type-1
MAT1A	Q00266	56	97	57	57	Metal binding	Note=Potassium;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A817
MAT1A	Q00266	56	97	70	70	Binding site	Note=Methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A817
MAT1A	Q00266	56	97	34	60	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P13444
MAT1A	Q00266	56	97	53	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBV
MAT1A	Q00266	56	97	64	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBV
MAT1A	Q00266	56	97	79	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBV
MAT1A	Q00266	56	97	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBV
MME	P08473	65	119	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	240	285	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	472	499	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	660	692	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	65	119	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	240	285	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	472	499	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	660	692	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	65	119	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	240	285	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	472	499	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	660	692	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	65	119	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	240	285	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	472	499	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	660	692	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	65	119	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	240	285	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	472	499	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	660	692	2	750	Chain	ID=PRO_0000078213;Note=Neprilysin
MME	P08473	65	119	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	240	285	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	472	499	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	660	692	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	65	119	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	240	285	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	472	499	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	660	692	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	65	119	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	240	285	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	472	499	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	660	692	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	65	119	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	240	285	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	472	499	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	660	692	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	65	119	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	240	285	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	472	499	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	660	692	52	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MME	P08473	65	119	103	103	Binding site	Note=Substrate carboxyl;Ontology_term=ECO:0000250;evidence=ECO:0000250
MME	P08473	65	119	103	103	Binding site	Note=Substrate carboxyl;Ontology_term=ECO:0000250;evidence=ECO:0000250
MME	P08473	65	119	103	103	Binding site	Note=Substrate carboxyl;Ontology_term=ECO:0000250;evidence=ECO:0000250
MME	P08473	65	119	103	103	Binding site	Note=Substrate carboxyl;Ontology_term=ECO:0000250;evidence=ECO:0000250
MME	P08473	65	119	103	103	Binding site	Note=Substrate carboxyl;Ontology_term=ECO:0000250;evidence=ECO:0000250
MME	P08473	240	285	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
MME	P08473	240	285	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
MME	P08473	240	285	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
MME	P08473	240	285	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
MME	P08473	240	285	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12754519;Dbxref=PMID:12754519
MME	P08473	65	119	80	735	Disulfide bond	.
MME	P08473	240	285	80	735	Disulfide bond	.
MME	P08473	472	499	80	735	Disulfide bond	.
MME	P08473	660	692	80	735	Disulfide bond	.
MME	P08473	65	119	80	735	Disulfide bond	.
MME	P08473	240	285	80	735	Disulfide bond	.
MME	P08473	472	499	80	735	Disulfide bond	.
MME	P08473	660	692	80	735	Disulfide bond	.
MME	P08473	65	119	80	735	Disulfide bond	.
MME	P08473	240	285	80	735	Disulfide bond	.
MME	P08473	472	499	80	735	Disulfide bond	.
MME	P08473	660	692	80	735	Disulfide bond	.
MME	P08473	65	119	80	735	Disulfide bond	.
MME	P08473	240	285	80	735	Disulfide bond	.
MME	P08473	472	499	80	735	Disulfide bond	.
MME	P08473	660	692	80	735	Disulfide bond	.
MME	P08473	65	119	80	735	Disulfide bond	.
MME	P08473	240	285	80	735	Disulfide bond	.
MME	P08473	472	499	80	735	Disulfide bond	.
MME	P08473	660	692	80	735	Disulfide bond	.
MME	P08473	65	119	88	695	Disulfide bond	.
MME	P08473	240	285	88	695	Disulfide bond	.
MME	P08473	472	499	88	695	Disulfide bond	.
MME	P08473	660	692	88	695	Disulfide bond	.
MME	P08473	65	119	88	695	Disulfide bond	.
MME	P08473	240	285	88	695	Disulfide bond	.
MME	P08473	472	499	88	695	Disulfide bond	.
MME	P08473	660	692	88	695	Disulfide bond	.
MME	P08473	65	119	88	695	Disulfide bond	.
MME	P08473	240	285	88	695	Disulfide bond	.
MME	P08473	472	499	88	695	Disulfide bond	.
MME	P08473	660	692	88	695	Disulfide bond	.
MME	P08473	65	119	88	695	Disulfide bond	.
MME	P08473	240	285	88	695	Disulfide bond	.
MME	P08473	472	499	88	695	Disulfide bond	.
MME	P08473	660	692	88	695	Disulfide bond	.
MME	P08473	65	119	88	695	Disulfide bond	.
MME	P08473	240	285	88	695	Disulfide bond	.
MME	P08473	472	499	88	695	Disulfide bond	.
MME	P08473	660	692	88	695	Disulfide bond	.
MME	P08473	240	285	143	411	Disulfide bond	.
MME	P08473	240	285	143	411	Disulfide bond	.
MME	P08473	240	285	143	411	Disulfide bond	.
MME	P08473	240	285	143	411	Disulfide bond	.
MME	P08473	240	285	143	411	Disulfide bond	.
MME	P08473	240	285	234	242	Disulfide bond	.
MME	P08473	240	285	234	242	Disulfide bond	.
MME	P08473	240	285	234	242	Disulfide bond	.
MME	P08473	240	285	234	242	Disulfide bond	.
MME	P08473	240	285	234	242	Disulfide bond	.
MME	P08473	660	692	621	747	Disulfide bond	.
MME	P08473	660	692	621	747	Disulfide bond	.
MME	P08473	660	692	621	747	Disulfide bond	.
MME	P08473	660	692	621	747	Disulfide bond	.
MME	P08473	660	692	621	747	Disulfide bond	.
MME	P08473	472	499	497	497	Natural variant	ID=VAR_077690;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26991897;Dbxref=dbSNP:rs200308207,PMID:26991897
MME	P08473	472	499	497	497	Natural variant	ID=VAR_077690;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26991897;Dbxref=dbSNP:rs200308207,PMID:26991897
MME	P08473	472	499	497	497	Natural variant	ID=VAR_077690;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26991897;Dbxref=dbSNP:rs200308207,PMID:26991897
MME	P08473	472	499	497	497	Natural variant	ID=VAR_077690;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26991897;Dbxref=dbSNP:rs200308207,PMID:26991897
MME	P08473	472	499	497	497	Natural variant	ID=VAR_077690;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26991897;Dbxref=dbSNP:rs200308207,PMID:26991897
MME	P08473	65	119	81	81	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MME	P08473	65	119	81	81	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MME	P08473	65	119	81	81	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MME	P08473	65	119	81	81	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MME	P08473	65	119	81	81	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MME	P08473	65	119	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	83	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	83	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	83	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	83	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	83	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	106	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	106	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	106	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	106	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	65	119	106	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	239	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	239	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	239	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	239	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	239	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	240	285	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	463	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	463	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	463	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	463	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	463	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	485	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	485	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	485	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	485	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	485	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	490	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	490	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	490	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	490	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	490	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	497	499	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	497	499	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	497	499	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	497	499	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	472	499	497	499	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	645	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	645	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	645	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	645	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	645	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	682	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	682	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	682	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	682	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
MME	P08473	660	692	682	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R1H
PRSS12	P56730	639	679	21	875	Chain	ID=PRO_0000027663;Note=Neurotrypsin
PRSS12	P56730	639	679	631	874	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
PRSS12	P56730	639	679	676	676	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
PRSS12	P56730	639	679	619	750	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRSS12	P56730	639	679	661	677	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PRSS12	P56730	639	679	663	663	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
OLFM2	O95897	71	120	21	454	Chain	ID=PRO_0000020078;Note=Noelin-2
OLFM2	O95897	71	120	58	85	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OLFM2	O95897	71	120	74	74	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
OLFM2	O95897	71	120	86	86	Natural variant	ID=VAR_036532;Note=In a colorectal cancer sample%3B somatic mutation%3B no effect on secretion. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:21228389;Dbxref=dbSNP:rs1298178636,PMID:16959974,PMID:21228389
OLFM2	O95897	71	120	106	106	Natural variant	ID=VAR_022550;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs2303100
NOX1	Q9Y5S8	432	481	1	564	Chain	ID=PRO_0000210148;Note=NADPH oxidase 1
NOX1	Q9Y5S8	268	299	1	564	Chain	ID=PRO_0000210148;Note=NADPH oxidase 1
NOX1	Q9Y5S8	47	84	1	564	Chain	ID=PRO_0000210148;Note=NADPH oxidase 1
NOX1	Q9Y5S8	47	84	45	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOX1	Q9Y5S8	47	84	73	102	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOX1	Q9Y5S8	268	299	228	396	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOX1	Q9Y5S8	432	481	418	564	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOX1	Q9Y5S8	268	299	54	283	Domain	Note=Ferric oxidoreductase
NOX1	Q9Y5S8	47	84	54	283	Domain	Note=Ferric oxidoreductase
NOX1	Q9Y5S8	268	299	284	391	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00716
NOX1	Q9Y5S8	432	481	397	536	Region	Note=Interaction with NOXO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16329988;Dbxref=PMID:16329988
NOX1	Q9Y5S8	432	481	191	564	Alternative sequence	ID=VSP_001578;Note=In isoform NOH-1S. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10615049;Dbxref=PMID:10615049
NOX1	Q9Y5S8	268	299	191	564	Alternative sequence	ID=VSP_001578;Note=In isoform NOH-1S. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10615049;Dbxref=PMID:10615049
NOX1	Q9Y5S8	432	481	433	481	Alternative sequence	ID=VSP_001579;Note=In isoform NOH-1LV. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10615049;Dbxref=PMID:10615049
NOTCH1	P46531	518	556	19	2555	Chain	ID=PRO_0000007674;Note=Neurogenic locus notch homolog protein 1
NOTCH1	P46531	480	518	19	2555	Chain	ID=PRO_0000007674;Note=Neurogenic locus notch homolog protein 1
NOTCH1	P46531	366	418	19	2555	Chain	ID=PRO_0000007674;Note=Neurogenic locus notch homolog protein 1
NOTCH1	P46531	518	556	19	1735	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH1	P46531	480	518	19	1735	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH1	P46531	366	418	19	1735	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH1	P46531	366	418	335	371	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	366	418	372	410	Domain	Note=EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	366	418	412	450	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	480	518	452	488	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	518	556	490	526	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	480	518	490	526	Domain	Note=EGF-like 13%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	518	556	528	564	Domain	Note=EGF-like 14%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH1	P46531	480	518	490	490	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	491	491	Metal binding	Note=Calcium 3%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	493	493	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	507	507	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	508	508	Metal binding	Note=Calcium 3%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	366	418	378	378	Glycosylation	Note=O-linked (Glc...) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01705
NOTCH1	P46531	480	518	496	496	Glycosylation	Note=O-linked (Glc...) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	518	556	534	534	Glycosylation	Note=O-linked (Glc...) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01705
NOTCH1	P46531	366	418	361	370	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	366	418	376	387	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	366	418	381	398	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	366	418	400	409	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	366	418	416	429	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	478	487	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	494	505	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	499	514	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	518	556	516	525	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	480	518	516	525	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q07008
NOTCH1	P46531	518	556	532	543	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	518	556	537	552	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	518	556	554	563	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH1	P46531	366	418	415	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0E
NOTCH1	P46531	366	418	418	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0E
NOTCH1	P46531	480	518	482	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0R
NOTCH1	P46531	480	518	493	496	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0E
NOTCH1	P46531	480	518	500	502	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VJ3
NOTCH1	P46531	480	518	504	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0E
NOTCH1	P46531	480	518	512	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0E
NOTCH1	P46531	518	556	520	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0E
NPIPA1	Q9UND3	146	181	1	350	Chain	ID=PRO_0000076275;Note=Nuclear pore complex-interacting protein family member A1
NPIPA5	E9PKD4	146	181	1	350	Chain	ID=PRO_0000423918;Note=Nuclear pore complex-interacting protein family member A5
NPIPA7	E9PJI5	146	181	1	369	Chain	ID=PRO_0000423925;Note=Nuclear pore complex-interacting protein family member A7
NPM2	Q86SE8	48	90	1	214	Chain	ID=PRO_0000219487;Note=Nucleoplasmin-2
NPM2	Q86SE8	48	90	1	214	Chain	ID=PRO_0000219487;Note=Nucleoplasmin-2
NPM2	Q86SE8	48	90	1	214	Chain	ID=PRO_0000219487;Note=Nucleoplasmin-2
NPM2	Q86SE8	48	90	1	214	Chain	ID=PRO_0000219487;Note=Nucleoplasmin-2
NPM2	Q86SE8	48	90	57	57	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	57	57	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	57	57	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	57	57	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	84	84	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	84	84	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	84	84	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	84	84	Site	Note=Interaction between pentamers
NPM2	Q86SE8	48	90	43	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	43	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	43	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	43	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	60	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	60	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	60	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	60	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	85	87	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	85	87	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	85	87	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	85	87	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	90	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	90	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	90	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPM2	Q86SE8	48	90	90	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T30
NPLOC4	Q8TAT6	483	522	2	608	Chain	ID=PRO_0000057941;Note=Nuclear protein localization protein 4 homolog
NPLOC4	Q8TAT6	451	483	2	608	Chain	ID=PRO_0000057941;Note=Nuclear protein localization protein 4 homolog
NPLOC4	Q8TAT6	307	331	2	608	Chain	ID=PRO_0000057941;Note=Nuclear protein localization protein 4 homolog
NPLOC4	Q8TAT6	278	307	2	608	Chain	ID=PRO_0000057941;Note=Nuclear protein localization protein 4 homolog
NPLOC4	Q8TAT6	218	278	2	608	Chain	ID=PRO_0000057941;Note=Nuclear protein localization protein 4 homolog
NPLOC4	Q8TAT6	70	128	2	608	Chain	ID=PRO_0000057941;Note=Nuclear protein localization protein 4 homolog
NPLOC4	Q8TAT6	307	331	226	363	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
NPLOC4	Q8TAT6	278	307	226	363	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
NPLOC4	Q8TAT6	218	278	226	363	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
NPLOC4	Q8TAT6	218	278	246	246	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPLOC4	Q8TAT6	218	278	248	248	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
NMRK2	Q9NPI5	108	131	1	230	Chain	ID=PRO_0000215894;Note=Nicotinamide riboside kinase 2
NMRK2	Q9NPI5	108	131	130	130	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NWW6
NMRK2	Q9NPI5	108	131	131	131	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NWW6
NT5DC2	Q9H857	336	365	1	520	Chain	ID=PRO_0000247224;Note=5'-nucleotidase domain-containing protein 2
NT5DC2	Q9H857	275	308	1	520	Chain	ID=PRO_0000247224;Note=5'-nucleotidase domain-containing protein 2
NT5DC2	Q9H857	102	127	1	520	Chain	ID=PRO_0000247224;Note=5'-nucleotidase domain-containing protein 2
NT5DC2	Q9H857	336	365	358	358	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
NT5DC2	Q9H857	102	127	1	130	Alternative sequence	ID=VSP_019951;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
NT5DC2	Q9H857	102	127	103	127	Alternative sequence	ID=VSP_019953;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NTM	Q9P121	133	175	34	321	Chain	ID=PRO_0000015110;Note=Neurotrimin
NTM	Q9P121	133	175	136	218	Domain	Note=Ig-like C2-type 2
NTM	Q9P121	133	175	152	152	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTM	Q9P121	133	175	157	201	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NEURL4	Q96JN8	242	264	1	1562	Chain	ID=PRO_0000299105;Note=Neuralized-like protein 4
NOC2L	Q9Y3T9	601	639	1	749	Chain	ID=PRO_0000121048;Note=Nucleolar complex protein 2 homolog
NOC2L	Q9Y3T9	553	601	1	749	Chain	ID=PRO_0000121048;Note=Nucleolar complex protein 2 homolog
NOC2L	Q9Y3T9	519	553	1	749	Chain	ID=PRO_0000121048;Note=Nucleolar complex protein 2 homolog
NOC2L	Q9Y3T9	9	59	1	749	Chain	ID=PRO_0000121048;Note=Nucleolar complex protein 2 homolog
NOC2L	Q9Y3T9	9	59	49	49	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
NOC2L	Q9Y3T9	9	59	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
NOC2L	Q9Y3T9	553	601	556	556	Natural variant	ID=VAR_050289;Note=S->L;Dbxref=dbSNP:rs35471880
NOL4	O94818	412	476	1	638	Chain	ID=PRO_0000096935;Note=Nucleolar protein 4
NOL4	O94818	412	476	413	514	Alternative sequence	ID=VSP_010080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:15489334
NOXO1	Q8NFA2	200	238	1	376	Chain	ID=PRO_0000227594;Note=NADPH oxidase organizer 1
NOXO1	Q8NFA2	200	238	163	225	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
NOXO1	Q8NFA2	200	238	237	296	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
NOXO1	Q8NFA2	200	238	202	202	Mutagenesis	Note=Loss of ability to activate NOX3 and interact with CYBA. Induces interaction with NOXA1 in vitro. W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15824103,ECO:0000269|PubMed:17126813;Dbxref=PMID:15824103,PMID:17126813
NOTCH2	Q04721	866	917	26	2471	Chain	ID=PRO_0000007683;Note=Neurogenic locus notch homolog protein 2
NOTCH2	Q04721	826	866	26	2471	Chain	ID=PRO_0000007683;Note=Neurogenic locus notch homolog protein 2
NOTCH2	Q04721	638	675	26	2471	Chain	ID=PRO_0000007683;Note=Neurogenic locus notch homolog protein 2
NOTCH2	Q04721	369	421	26	2471	Chain	ID=PRO_0000007683;Note=Neurogenic locus notch homolog protein 2
NOTCH2	Q04721	250	291	26	2471	Chain	ID=PRO_0000007683;Note=Neurogenic locus notch homolog protein 2
NOTCH2	Q04721	138	250	26	2471	Chain	ID=PRO_0000007683;Note=Neurogenic locus notch homolog protein 2
NOTCH2	Q04721	866	917	26	1677	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	826	866	26	1677	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	638	675	26	1677	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	369	421	26	1677	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	250	291	26	1677	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	138	250	26	1677	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	138	250	105	143	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	138	250	144	180	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	138	250	182	219	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	250	291	221	258	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	138	250	221	258	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	250	291	260	296	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	369	421	338	374	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	369	421	375	413	Domain	Note=EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	369	421	415	454	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	638	675	607	643	Domain	Note=EGF-like 16%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	638	675	645	680	Domain	Note=EGF-like 17%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	826	866	795	831	Domain	Note=EGF-like 21%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	866	917	833	871	Domain	Note=EGF-like 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	826	866	833	871	Domain	Note=EGF-like 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	866	917	873	909	Domain	Note=EGF-like 23%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	866	917	911	947	Domain	Note=EGF-like 24%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH2	Q04721	138	250	155	155	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH2	Q04721	138	250	133	142	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	148	159	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	153	168	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	170	179	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	186	198	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	192	207	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	209	218	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	225	236	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	230	246	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	250	291	248	257	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	248	257	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	250	291	264	275	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	250	291	269	284	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	250	291	286	295	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	369	421	364	373	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	369	421	379	390	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	369	421	384	401	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	369	421	403	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	369	421	419	433	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	638	675	633	642	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	638	675	649	659	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	638	675	654	668	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	638	675	670	679	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	826	866	821	830	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	826	866	837	848	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	826	866	842	859	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	866	917	861	870	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	826	866	861	870	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	866	917	877	888	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	866	917	882	897	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	866	917	899	908	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	866	917	915	926	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH2	Q04721	138	250	210	210	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NOTCH2	Q04721	369	421	418	420	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MWB
NOTCH3	Q9UM47	803	855	40	2321	Chain	ID=PRO_0000007692;Note=Neurogenic locus notch homolog protein 3
NOTCH3	Q9UM47	613	650	40	2321	Chain	ID=PRO_0000007692;Note=Neurogenic locus notch homolog protein 3
NOTCH3	Q9UM47	459	497	40	2321	Chain	ID=PRO_0000007692;Note=Neurogenic locus notch homolog protein 3
NOTCH3	Q9UM47	397	459	40	2321	Chain	ID=PRO_0000007692;Note=Neurogenic locus notch homolog protein 3
NOTCH3	Q9UM47	226	267	40	2321	Chain	ID=PRO_0000007692;Note=Neurogenic locus notch homolog protein 3
NOTCH3	Q9UM47	803	855	40	1643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH3	Q9UM47	613	650	40	1643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH3	Q9UM47	459	497	40	1643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH3	Q9UM47	397	459	40	1643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH3	Q9UM47	226	267	40	1643	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOTCH3	Q9UM47	226	267	197	234	Domain	Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	226	267	236	272	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	397	459	391	429	Domain	Note=EGF-like 10%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	459	497	431	467	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	397	459	431	467	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	459	497	469	505	Domain	Note=EGF-like 12%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	613	650	582	618	Domain	Note=EGF-like 15%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	613	650	620	655	Domain	Note=EGF-like 16%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	803	855	771	808	Domain	Note=EGF-like 20;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	803	855	810	847	Domain	Note=EGF-like 21%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	803	855	849	885	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NOTCH3	Q9UM47	226	267	224	233	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	226	267	240	251	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	226	267	245	260	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	226	267	262	271	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	397	459	395	408	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	397	459	402	417	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	397	459	419	428	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	397	459	435	446	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	397	459	440	455	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	459	497	457	466	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	397	459	457	466	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	459	497	473	484	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	459	497	478	493	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	459	497	495	504	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	613	650	608	617	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	613	650	624	634	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	613	650	629	643	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	613	650	645	654	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	803	855	798	807	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	803	855	814	826	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	803	855	820	835	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	803	855	837	846	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	803	855	853	864	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NOTCH3	Q9UM47	226	267	233	233	Natural variant	ID=VAR_044281;Note=In CADASIL1. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12146805;Dbxref=PMID:12146805
NOTCH3	Q9UM47	226	267	233	233	Natural variant	ID=VAR_044282;Note=In CADASIL1. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	226	267	239	253	Natural variant	ID=VAR_044283;Note=In CADASIL1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	226	267	240	240	Natural variant	ID=VAR_044284;Note=In CADASIL1. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	226	267	245	245	Natural variant	ID=VAR_044285;Note=In CADASIL1. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	226	267	251	251	Natural variant	ID=VAR_044286;Note=In CADASIL1. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12146805,ECO:0000269|PubMed:15229130;Dbxref=PMID:12146805,PMID:15229130
NOTCH3	Q9UM47	226	267	258	258	Natural variant	ID=VAR_012888;Note=In CADASIL1. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11102981,ECO:0000269|PubMed:9388399;Dbxref=PMID:11102981,PMID:9388399
NOTCH3	Q9UM47	226	267	260	260	Natural variant	ID=VAR_044287;Note=In CADASIL1. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	397	459	420	420	Natural variant	ID=VAR_044294;Note=In CADASIL1. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12146805;Dbxref=PMID:12146805
NOTCH3	Q9UM47	397	459	421	421	Natural variant	ID=VAR_044295;Note=In CADASIL1. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	397	459	428	428	Natural variant	ID=VAR_044296;Note=In CADASIL1. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11755616;Dbxref=dbSNP:rs267606915,PMID:11755616
NOTCH3	Q9UM47	397	459	428	428	Natural variant	ID=VAR_044297;Note=In CADASIL1. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	397	459	440	440	Natural variant	ID=VAR_044298;Note=In CADASIL1. C->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12146805,ECO:0000269|PubMed:15229130;Dbxref=PMID:12146805,PMID:15229130
NOTCH3	Q9UM47	397	459	440	440	Natural variant	ID=VAR_044299;Note=In CADASIL1. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	397	459	446	446	Natural variant	ID=VAR_044300;Note=In CADASIL1. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15364702;Dbxref=PMID:15364702
NOTCH3	Q9UM47	397	459	449	449	Natural variant	ID=VAR_044301;Note=In CADASIL1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12146805;Dbxref=PMID:12146805
NOTCH3	Q9UM47	397	459	455	455	Natural variant	ID=VAR_044302;Note=In CADASIL1%3B impaired ligand-binding%3B strongly reduced signaling activity%3B no effect on cell membrane localization%3B reduced proteolytic processing. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12136071,ECO:0000269|PubMed:15350543;Dbxref=dbSNP:rs28933698,PMID:12136071,PMID:15350543
NOTCH3	Q9UM47	459	497	484	484	Natural variant	ID=VAR_044303;Note=In CADASIL1. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16009764;Dbxref=PMID:16009764
NOTCH3	Q9UM47	459	497	484	484	Natural variant	ID=VAR_044304;Note=In CADASIL1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15364702;Dbxref=PMID:15364702
NOTCH3	Q9UM47	459	497	495	495	Natural variant	ID=VAR_044305;Note=In CADASIL1. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15364702,ECO:0000269|PubMed:16009764;Dbxref=PMID:15364702,PMID:16009764
NOTCH3	Q9UM47	459	497	496	496	Natural variant	ID=VAR_012889;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9388399;Dbxref=dbSNP:rs11670799,PMID:9388399
NPAS2	Q99743	91	121	1	824	Chain	ID=PRO_0000127406;Note=Neuronal PAS domain-containing protein 2
NPAS2	Q99743	161	199	1	824	Chain	ID=PRO_0000127406;Note=Neuronal PAS domain-containing protein 2
NPAS2	Q99743	543	609	1	824	Chain	ID=PRO_0000127406;Note=Neuronal PAS domain-containing protein 2
NPAS2	Q99743	673	703	1	824	Chain	ID=PRO_0000127406;Note=Neuronal PAS domain-containing protein 2
NPAS2	Q99743	91	121	82	152	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
NPAS2	Q99743	91	121	119	119	Metal binding	Note=Iron (heme B axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97460
NPAS2	Q99743	161	199	171	171	Metal binding	Note=Iron (heme B axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97460
NPAS2	Q99743	161	199	164	164	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPHP4	O75161	1272	1332	1	1426	Chain	ID=PRO_0000159769;Note=Nephrocystin-4
NPHP4	O75161	1077	1105	1	1426	Chain	ID=PRO_0000159769;Note=Nephrocystin-4
NPHP4	O75161	501	537	1	1426	Chain	ID=PRO_0000159769;Note=Nephrocystin-4
NPHP4	O75161	45	93	1	1426	Chain	ID=PRO_0000159769;Note=Nephrocystin-4
NPHP4	O75161	1272	1332	823	1426	Region	Note=Sufficient for basal bodies localization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26644512;Dbxref=PMID:26644512
NPHP4	O75161	1077	1105	823	1426	Region	Note=Sufficient for basal bodies localization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26644512;Dbxref=PMID:26644512
NPHP4	O75161	1272	1332	913	1426	Alternative sequence	ID=VSP_054516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NPHP4	O75161	1077	1105	913	1426	Alternative sequence	ID=VSP_054516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NPHP4	O75161	45	93	91	91	Natural variant	ID=VAR_022528;Note=In SLSN4%3B also found in a patient with cardiac laterality defects%3B impairs localization to the ciliary transition zone. F->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:15776426,ECO:0000269|PubMed:22550138,ECO:0000305|PubMed:21546380;Dbxref=dbSNP:rs201065230,PMID:15776426,PMID:22550138,PMID:21546380
NPHP4	O75161	1077	1105	1098	1098	Natural variant	ID=VAR_022544;Note=In NPHP4. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776426;Dbxref=dbSNP:rs41280798,PMID:15776426
NPHP4	O75161	1272	1332	1284	1284	Natural variant	ID=VAR_022547;Note=In NPHP4. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776426;Dbxref=dbSNP:rs779755743,PMID:15776426
NPHP4	O75161	1272	1332	1287	1287	Natural variant	ID=VAR_022548;Note=In NPHP4%3B with hearing loss. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776426;Dbxref=dbSNP:rs201779243,PMID:15776426
NR1H3	Q13133	77	166	1	447	Chain	ID=PRO_0000053535;Note=Oxysterols receptor LXR-alpha
NR1H3	Q13133	236	296	1	447	Chain	ID=PRO_0000053535;Note=Oxysterols receptor LXR-alpha
NR1H3	Q13133	329	367	1	447	Chain	ID=PRO_0000053535;Note=Oxysterols receptor LXR-alpha
NR1H3	Q13133	77	166	1	447	Chain	ID=PRO_0000053535;Note=Oxysterols receptor LXR-alpha
NR1H3	Q13133	236	296	1	447	Chain	ID=PRO_0000053535;Note=Oxysterols receptor LXR-alpha
NR1H3	Q13133	329	367	1	447	Chain	ID=PRO_0000053535;Note=Oxysterols receptor LXR-alpha
NR1H3	Q13133	236	296	209	447	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR1H3	Q13133	329	367	209	447	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR1H3	Q13133	236	296	209	447	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR1H3	Q13133	329	367	209	447	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR1H3	Q13133	77	166	95	170	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H3	Q13133	77	166	95	170	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H3	Q13133	77	166	98	118	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H3	Q13133	77	166	98	118	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H3	Q13133	77	166	134	158	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H3	Q13133	77	166	134	158	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H3	Q13133	77	166	1	96	Region	Note=Transactivation AF-1%3B required for ligand-independent transactivation function;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H3	Q13133	77	166	1	96	Region	Note=Transactivation AF-1%3B required for ligand-independent transactivation function;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H3	Q13133	236	296	205	447	Region	Note=Transactivation AF-2%3B required for ligand-dependent transactivation function%3B mediates interaction with CCAR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H3	Q13133	329	367	205	447	Region	Note=Transactivation AF-2%3B required for ligand-dependent transactivation function%3B mediates interaction with CCAR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H3	Q13133	236	296	205	447	Region	Note=Transactivation AF-2%3B required for ligand-dependent transactivation function%3B mediates interaction with CCAR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H3	Q13133	329	367	205	447	Region	Note=Transactivation AF-2%3B required for ligand-dependent transactivation function%3B mediates interaction with CCAR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H3	Q13133	236	296	237	296	Alternative sequence	ID=VSP_003664;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NR1H3	Q13133	236	296	237	296	Alternative sequence	ID=VSP_003664;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NR1H3	Q13133	236	296	268	273	Mutagenesis	Note=Abolishes interaction with NCOA2 without affecting interaction with GPS2%3B when associated with 438-A-A-439. IVDFAK->EVDFAE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19481530;Dbxref=PMID:19481530
NR1H3	Q13133	236	296	268	273	Mutagenesis	Note=Abolishes interaction with NCOA2 without affecting interaction with GPS2%3B when associated with 438-A-A-439. IVDFAK->EVDFAE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19481530;Dbxref=PMID:19481530
NR1H3	Q13133	236	296	247	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	236	296	247	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	236	296	278	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	236	296	278	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	236	296	283	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	236	296	283	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	329	367	333	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	329	367	333	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	329	367	353	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H3	Q13133	329	367	353	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HJS
NR1H4	Q96RI1	26	148	1	486	Chain	ID=PRO_0000053538;Note=Bile acid receptor
NR1H4	Q96RI1	148	199	1	486	Chain	ID=PRO_0000053538;Note=Bile acid receptor
NR1H4	Q96RI1	26	148	134	209	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H4	Q96RI1	148	199	134	209	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H4	Q96RI1	26	148	137	157	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H4	Q96RI1	148	199	137	157	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H4	Q96RI1	148	199	173	197	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H4	Q96RI1	26	148	145	145	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856
NR1H4	Q96RI1	148	199	164	164	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856
NR1H4	Q96RI1	148	199	167	167	Modified residue	Note=N6-acetyllysine%3B by EP300
NR1H4	Q96RI1	26	148	132	132	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23546875;Dbxref=PMID:23546875
NR1H4	Q96RI1	26	148	1	36	Alternative sequence	ID=VSP_010135;Note=In isoform 3%2C isoform 4 and isoform 5. MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAK->MGSKMNLIEHSHLPTTDEFSFSENLF;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1,ECO:0000303|Ref.2;Dbxref=PMID:15489334
NR1H4	Q96RI1	148	199	159	209	Alternative sequence	ID=VSP_044547;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NR1H4	Q96RI1	148	199	149	149	Natural variant	ID=VAR_077017;Note=In PFIC5%3B loss of isoform 4 transcription regulatory region sequence-specific DNA binding activity%3B loss of isoform 4 function in regulation of transcription DNA-templated. Y->YK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26888176;Dbxref=PMID:26888176
NR1H4	Q96RI1	26	148	132	132	Mutagenesis	Note=Abrogates SUMO1-medieated inhibition of ligand-induced transcactivation at ABCB11/BSEP and NR0B2/SHP promoters%3B when associated with R-289 and A-291. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23546875;Dbxref=PMID:23546875
NR1H4	Q96RI1	26	148	132	132	Mutagenesis	Note=Decreases transcriptional activation SLC51A/OSTA%2C SLC51B/OSTB and ABCB11/BSEP%2C no effect on interaction with RXRA and SETD7. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506
NR1H4	Q96RI1	26	148	145	145	Mutagenesis	Note=Impairs ligand-dependent transactivation activity%2C impairs interaction with PPARGC1A%3B when associated with A-164. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856
NR1H4	Q96RI1	148	199	164	164	Mutagenesis	Note=Impairs ligand-dependent transactivation activity%2C impairs interaction with PPARGC1A%3B when associated with A-145. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856
NR1H4	Q96RI1	148	199	167	167	Mutagenesis	Note=Decreases transcriptional activation of SLC51B/OSTB%2C no effect on SLC51A/OSTA and ABCB11/BSEP%2C no effect on interaction with RXRA and SETD7. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506
NR1H4	Q96RI1	148	199	198	198	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NR2C1	P13056	464	510	1	603	Chain	ID=PRO_0000053586;Note=Nuclear receptor subfamily 2 group C member 1
NR2C1	P13056	464	510	348	590	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR2C1	P13056	464	510	465	467	Alternative sequence	ID=VSP_036855;Note=In isoform 2. DKM->AEG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2597158;Dbxref=PMID:15489334,PMID:2597158
NR2C1	P13056	464	510	466	483	Alternative sequence	ID=VSP_036856;Note=In isoform 3. KMSTERRKLLMEHIFKLQ->AKVIAALIHFTRRAITDL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3421977;Dbxref=PMID:3421977
NR2C1	P13056	464	510	468	603	Alternative sequence	ID=VSP_036857;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2597158;Dbxref=PMID:15489334,PMID:2597158
NR2C1	P13056	464	510	484	603	Alternative sequence	ID=VSP_036858;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3421977;Dbxref=PMID:3421977
NRDE2	Q9H7Z3	614	743	2	1164	Chain	ID=PRO_0000089907;Note=Protein NRDE2 homolog
NRDE2	Q9H7Z3	136	185	2	1164	Chain	ID=PRO_0000089907;Note=Protein NRDE2 homolog
NRDE2	Q9H7Z3	58	135	2	1164	Chain	ID=PRO_0000089907;Note=Protein NRDE2 homolog
NRDE2	Q9H7Z3	136	185	61	383	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NRDE2	Q9H7Z3	58	135	61	383	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NRDE2	Q9H7Z3	58	135	73	101	Compositional bias	Note=Lys-rich
NRDE2	Q9H7Z3	58	135	81	91	Compositional bias	Note=Poly-Lys
NRDE2	Q9H7Z3	58	135	105	110	Compositional bias	Note=Poly-Ser
NRDE2	Q9H7Z3	58	135	117	117	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRDE2	Q9H7Z3	614	743	694	694	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFIA	Q12857	186	208	1	509	Chain	ID=PRO_0000100191;Note=Nuclear factor 1 A-type
NFIA	Q12857	208	233	1	509	Chain	ID=PRO_0000100191;Note=Nuclear factor 1 A-type
NFIA	Q12857	315	358	1	509	Chain	ID=PRO_0000100191;Note=Nuclear factor 1 A-type
NFIA	Q12857	186	208	1	194	DNA binding	Note=CTF/NF-I;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00436
NFIA	Q12857	315	358	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NFIA	Q12857	186	208	186	186	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFIA	Q12857	315	358	331	331	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFIA	Q12857	315	358	358	358	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NINL	Q9Y2I6	734	1082	1	1382	Chain	ID=PRO_0000259714;Note=Ninein-like protein
NINL	Q9Y2I6	390	436	1	1382	Chain	ID=PRO_0000259714;Note=Ninein-like protein
NINL	Q9Y2I6	287	344	1	1382	Chain	ID=PRO_0000259714;Note=Ninein-like protein
NINL	Q9Y2I6	390	436	384	424	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NINL	Q9Y2I6	734	1082	1046	1375	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NINL	Q9Y2I6	287	344	296	299	Compositional bias	Note=Poly-Thr
NINL	Q9Y2I6	734	1082	805	810	Compositional bias	Note=Poly-Glu
NINL	Q9Y2I6	734	1082	735	1083	Alternative sequence	ID=VSP_037883;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18826961;Dbxref=PMID:18826961
NINL	Q9Y2I6	287	344	296	296	Natural variant	ID=VAR_059703;Note=T->A;Dbxref=dbSNP:rs379538
NINL	Q9Y2I6	734	1082	969	969	Natural variant	ID=VAR_058509;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6115193,PMID:15489334
NINL	Q9Y2I6	734	1082	973	973	Natural variant	ID=VAR_059704;Note=E->K;Dbxref=dbSNP:rs428801
NINL	Q9Y2I6	734	1082	1077	1077	Natural variant	ID=VAR_061688;Note=D->N;Dbxref=dbSNP:rs35666277
NINL	Q9Y2I6	287	344	303	303	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NINL	Q9Y2I6	734	1082	958	959	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
C17orf75	Q9HAS0	74	115	1	396	Chain	ID=PRO_0000096865;Note=Protein Njmu-R1
NMU	P48645	103	120	35	103	Propeptide	ID=PRO_0000019772
NMU	P48645	57	73	35	103	Propeptide	ID=PRO_0000019772
NMU	P48645	120	145	104	138	Propeptide	ID=PRO_0000262495;Ontology_term=ECO:0000250;evidence=ECO:0000250
NMU	P48645	103	120	104	138	Propeptide	ID=PRO_0000262495;Ontology_term=ECO:0000250;evidence=ECO:0000250
NMU	P48645	120	145	139	141	Propeptide	ID=PRO_0000262496;Ontology_term=ECO:0000250;evidence=ECO:0000250
NMU	P48645	120	145	142	166	Peptide	ID=PRO_0000019773;Note=Neuromedin-U-25
GRIN3B	O60391	822	877	23	1043	Chain	ID=PRO_0000011570;Note=Glutamate receptor ionotropic%2C NMDA 3B
GRIN3B	O60391	822	877	670	830	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIN3B	O60391	822	877	831	851	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIN3B	O60391	822	877	852	1043	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIN3B	O60391	822	877	845	845	Natural variant	ID=VAR_019680;Note=A->T;Dbxref=dbSNP:rs2285906
NMT1	P30419	199	237	1	496	Chain	ID=PRO_0000064221;Note=Glycylpeptide N-tetradecanoyltransferase 1
NMT1	P30419	444	490	1	496	Chain	ID=PRO_0000064221;Note=Glycylpeptide N-tetradecanoyltransferase 1
NMT1	P30419	199	237	1	496	Chain	ID=PRO_0000064221;Note=Glycylpeptide N-tetradecanoyltransferase 1
NMT1	P30419	444	490	1	496	Chain	ID=PRO_0000064221;Note=Glycylpeptide N-tetradecanoyltransferase 1
NMT1	P30419	199	237	194	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	194	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	208	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	208	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	211	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	211	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	217	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	217	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	222	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	199	237	222	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	431	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	431	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	448	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	448	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	458	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	458	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	461	466	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	461	466	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	468	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	468	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	488	490	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NMT1	P30419	444	490	488	490	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6H
NOL10	Q9BSC4	252	302	1	688	Chain	ID=PRO_0000051101;Note=Nucleolar protein 10
NOL10	Q9BSC4	70	96	1	688	Chain	ID=PRO_0000051101;Note=Nucleolar protein 10
NOL10	Q9BSC4	37	70	1	688	Chain	ID=PRO_0000051101;Note=Nucleolar protein 10
NOL10	Q9BSC4	70	96	44	82	Repeat	Note=WD 1
NOL10	Q9BSC4	37	70	44	82	Repeat	Note=WD 1
NOL10	Q9BSC4	70	96	88	124	Repeat	Note=WD 2
NOL10	Q9BSC4	252	302	219	258	Repeat	Note=WD 5
NOL10	Q9BSC4	252	302	262	300	Repeat	Note=WD 6
NOL10	Q9BSC4	70	96	1	150	Alternative sequence	ID=VSP_015454;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOL10	Q9BSC4	37	70	1	150	Alternative sequence	ID=VSP_015454;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOL10	Q9BSC4	70	96	71	96	Alternative sequence	ID=VSP_045122;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOL10	Q9BSC4	252	302	253	302	Alternative sequence	ID=VSP_015456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOMO1	Q15155	245	291	32	1222	Chain	ID=PRO_0000021819;Note=Nodal modulator 1
NOMO1	Q15155	685	757	32	1222	Chain	ID=PRO_0000021819;Note=Nodal modulator 1
NOMO1	Q15155	1009	1037	32	1222	Chain	ID=PRO_0000021819;Note=Nodal modulator 1
NOMO1	Q15155	1074	1108	32	1222	Chain	ID=PRO_0000021819;Note=Nodal modulator 1
NOMO1	Q15155	1108	1148	32	1222	Chain	ID=PRO_0000021819;Note=Nodal modulator 1
NOMO1	Q15155	1148	1179	32	1222	Chain	ID=PRO_0000021819;Note=Nodal modulator 1
NOMO1	Q15155	245	291	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	685	757	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1009	1037	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1074	1108	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1108	1148	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1148	1179	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1148	1179	1156	1176	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1148	1179	1177	1222	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO1	Q15155	1074	1108	1081	1081	Natural variant	ID=VAR_011496;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10835642;Dbxref=dbSNP:rs200317822,PMID:10835642
NOMO1	Q15155	1108	1148	1141	1141	Natural variant	ID=VAR_013315;Note=I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11139250;Dbxref=dbSNP:rs376397163,PMID:11139250
NOMO1	Q15155	1108	1148	1141	1141	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPSNAP3A	Q9UFN0	143	193	1	247	Chain	ID=PRO_0000221152;Note=Protein NipSnap homolog 3A
NIPSNAP3A	Q9UFN0	193	222	1	247	Chain	ID=PRO_0000221152;Note=Protein NipSnap homolog 3A
NIPSNAP3A	Q9UFN0	143	193	166	166	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NPAT	Q14207	377	928	1	1427	Chain	ID=PRO_0000318163;Note=Protein NPAT
NPAT	Q14207	377	928	629	653	Region	Note=Required for acceleration of G1 phase
NPAT	Q14207	377	928	828	853	Region	Note=Required for acceleration of G1 phase
NPAT	Q14207	377	928	554	554	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NPAT	Q14207	377	928	599	599	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMA5
NPAT	Q14207	377	928	775	775	Modified residue	Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10995387;Dbxref=PMID:10995387
NPAT	Q14207	377	928	779	779	Modified residue	Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10995387;Dbxref=PMID:10995387
NPAT	Q14207	377	928	399	399	Natural variant	ID=VAR_038697;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8923007;Dbxref=dbSNP:rs1051521,PMID:8923007
NPAT	Q14207	377	928	447	447	Natural variant	ID=VAR_038698;Note=V->M;Dbxref=dbSNP:rs35504388
NPAT	Q14207	377	928	483	483	Natural variant	ID=VAR_038699;Note=I->L;Dbxref=dbSNP:rs968207
NPAT	Q14207	377	928	540	540	Natural variant	ID=VAR_038700;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs4144901,PMID:14702039
NPAT	Q14207	377	928	575	575	Natural variant	ID=VAR_038701;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8743993,ECO:0000269|PubMed:8923007,ECO:0000269|PubMed:9205109;Dbxref=dbSNP:rs2070661,PMID:14702039,PMID:15489334,PMID:8743993,PMID:8923007,PMID:9205109
NPAT	Q14207	377	928	608	608	Natural variant	ID=VAR_038702;Note=V->A;Dbxref=dbSNP:rs35095430
NPAT	Q14207	377	928	621	621	Natural variant	ID=VAR_038703;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8923007;Dbxref=dbSNP:rs1051522,PMID:8923007
NPAT	Q14207	377	928	775	775	Mutagenesis	Note=Impairs activation of histone gene transcription%3B when associated with A-779%3B A-1100%3B A-1270 and A-1350. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10995387,ECO:0000269|PubMed:14585971,ECO:0000269|PubMed:15555599,ECO:0000269|PubMed:17163457;Dbxref=PMID:10995387,PMID:14585971,PMID:15555599,PMID:17163457
NPAT	Q14207	377	928	779	779	Mutagenesis	Note=Impairs activation of histone gene transcription%3B when associated with A-775%3B A-1100%3B A-1270 and A-1350. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10995387,ECO:0000269|PubMed:14585971,ECO:0000269|PubMed:15555599,ECO:0000269|PubMed:17163457;Dbxref=PMID:10995387,PMID:14585971,PMID:15555599,PMID:17163457
NPAT	Q14207	377	928	471	471	Sequence conflict	Note=Y->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPAT	Q14207	377	928	785	785	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRF1	Q16656	155	202	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	202	255	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	255	321	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	155	202	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	202	255	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	255	321	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	155	202	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	202	255	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	255	321	1	503	Chain	ID=PRO_0000100208;Note=Nuclear respiratory factor 1
NRF1	Q16656	155	202	109	305	DNA binding	.
NRF1	Q16656	202	255	109	305	DNA binding	.
NRF1	Q16656	255	321	109	305	DNA binding	.
NRF1	Q16656	155	202	109	305	DNA binding	.
NRF1	Q16656	202	255	109	305	DNA binding	.
NRF1	Q16656	255	321	109	305	DNA binding	.
NRF1	Q16656	155	202	109	305	DNA binding	.
NRF1	Q16656	202	255	109	305	DNA binding	.
NRF1	Q16656	255	321	109	305	DNA binding	.
NRF1	Q16656	255	321	301	476	Region	Note=Required for transcriptional activation
NRF1	Q16656	255	321	301	476	Region	Note=Required for transcriptional activation
NRF1	Q16656	255	321	301	476	Region	Note=Required for transcriptional activation
NRF1	Q16656	155	202	1	161	Alternative sequence	ID=VSP_054330;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NRF1	Q16656	155	202	1	161	Alternative sequence	ID=VSP_054330;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NRF1	Q16656	155	202	1	161	Alternative sequence	ID=VSP_054330;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NRF1	Q16656	255	321	256	321	Alternative sequence	ID=VSP_003598;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRF1	Q16656	255	321	256	321	Alternative sequence	ID=VSP_003598;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRF1	Q16656	255	321	256	321	Alternative sequence	ID=VSP_003598;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCSK1	P29120	294	365	111	753	Chain	ID=PRO_0000027058;Note=Neuroendocrine convertase 1
PCSK1	P29120	294	365	162	451	Domain	Note=Peptidase S8
PCSK1	P29120	294	365	225	374	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PCSK1	P29120	294	365	317	347	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PCSK1	P29120	294	365	307	307	Natural variant	ID=VAR_055002;Note=In PC1 deficiency%3B in vitro the mutation markedly impairs the catalytic activity of the enzyme%3B however intracellular trafficking of this mutant enzyme appears normal%3B retains some autocatalytic activity even though it is completely inactive on other substrates. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595246;Dbxref=dbSNP:rs137852824,PMID:17595246
PCSK1	P29120	294	365	357	357	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NELL2	Q99435	725	800	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	554	601	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	481	522	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	396	439	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	725	800	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	554	601	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	481	522	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	396	439	22	816	Chain	ID=PRO_0000007666;Note=Protein kinase C-binding protein NELL2
NELL2	Q99435	396	439	397	439	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	396	439	397	439	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	440	481	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	440	481	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	482	522	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	482	522	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	555	601	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	555	601	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	725	800	698	756	Domain	Note=VWFC 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
NELL2	Q99435	725	800	698	756	Domain	Note=VWFC 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
NELL2	Q99435	481	522	517	517	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NELL2	Q99435	481	522	517	517	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NELL2	Q99435	396	439	401	413	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	396	439	401	413	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	396	439	407	422	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	396	439	407	422	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	396	439	424	438	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	396	439	424	438	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	486	499	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	486	499	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	493	508	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	493	508	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	510	521	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	510	521	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	559	572	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	559	572	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	566	581	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	566	581	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	583	600	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	554	601	583	600	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL2	Q99435	481	522	489	489	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NELL2	Q99435	481	522	489	489	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEK6	Q9HC98	30	77	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	98	135	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	171	207	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	239	277	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	30	77	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	98	135	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	171	207	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	239	277	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	30	77	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	98	135	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	171	207	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	239	277	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	30	77	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	98	135	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	171	207	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	239	277	1	313	Chain	ID=PRO_0000086427;Note=Serine/threonine-protein kinase Nek6
NEK6	Q9HC98	30	77	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	98	135	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	171	207	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	239	277	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	98	135	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	171	207	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	239	277	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	98	135	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	171	207	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	239	277	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	98	135	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	171	207	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	239	277	45	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	51	59	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	51	59	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	51	59	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	51	59	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	1	44	Region	Note=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
NEK6	Q9HC98	30	77	1	44	Region	Note=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
NEK6	Q9HC98	30	77	1	44	Region	Note=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
NEK6	Q9HC98	30	77	1	44	Region	Note=Interaction with ARHGAP33%2C ANKRA2%2C CDC42%2C PRDX3%2C RAD26L%2C RBBP6%2C RPS7 and TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20873783;Dbxref=PMID:20873783
NEK6	Q9HC98	239	277	267	270	Region	Note=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
NEK6	Q9HC98	239	277	267	270	Region	Note=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
NEK6	Q9HC98	239	277	267	270	Region	Note=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
NEK6	Q9HC98	239	277	267	270	Region	Note=Interaction with APBB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512906;Dbxref=PMID:17512906
NEK6	Q9HC98	171	207	172	172	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
NEK6	Q9HC98	171	207	172	172	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
NEK6	Q9HC98	171	207	172	172	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
NEK6	Q9HC98	171	207	172	172	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
NEK6	Q9HC98	30	77	74	74	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	74	74	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	74	74	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	30	77	74	74	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK6	Q9HC98	98	135	108	108	Site	Note=Autoinhibitory
NEK6	Q9HC98	98	135	108	108	Site	Note=Autoinhibitory
NEK6	Q9HC98	98	135	108	108	Site	Note=Autoinhibitory
NEK6	Q9HC98	98	135	108	108	Site	Note=Autoinhibitory
NEK6	Q9HC98	30	77	37	37	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	30	77	37	37	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	30	77	37	37	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	30	77	37	37	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	171	207	202	202	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	171	207	202	202	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	171	207	202	202	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	171	207	202	202	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12840024;Dbxref=PMID:12840024
NEK6	Q9HC98	171	207	206	206	Modified residue	Note=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12840024,PMID:20873783
NEK6	Q9HC98	171	207	206	206	Modified residue	Note=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12840024,PMID:20873783
NEK6	Q9HC98	171	207	206	206	Modified residue	Note=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12840024,PMID:20873783
NEK6	Q9HC98	171	207	206	206	Modified residue	Note=Phosphoserine%3B by NEK9;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:20873783;Dbxref=PMID:19369195,PMID:23186163,PMID:12840024,PMID:20873783
NEK6	Q9HC98	30	77	74	74	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	74	74	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	74	74	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	74	74	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-75. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	75	75	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	75	75	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	75	75	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	30	77	75	75	Mutagenesis	Note=Loss of autophosphorylation and of kinase activity and induction of apoptosis%3B when associated with M-74. K->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:19001501;Dbxref=PMID:14563848,PMID:19001501
NEK6	Q9HC98	98	135	108	108	Mutagenesis	Note=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK6	Q9HC98	98	135	108	108	Mutagenesis	Note=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK6	Q9HC98	98	135	108	108	Mutagenesis	Note=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
NEK6	Q9HC98	98	135	108	108	Mutagenesis	Note=Increase in catalytic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19941817;Dbxref=PMID:19941817
SERPINI1	Q99574	160	225	17	410	Chain	ID=PRO_0000032521;Note=Neuroserpin
SERPINI1	Q99574	160	225	17	410	Chain	ID=PRO_0000032521;Note=Neuroserpin
SERPINI1	Q99574	160	225	161	161	Mutagenesis	Note=Increases protein stability and abolishes tendency to form polymers. No effect on inhibitory activity. N->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285087;Dbxref=PMID:19285087
SERPINI1	Q99574	160	225	161	161	Mutagenesis	Note=Increases protein stability and abolishes tendency to form polymers. No effect on inhibitory activity. N->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285087;Dbxref=PMID:19285087
SERPINI1	Q99574	160	225	162	162	Mutagenesis	Note=Increases protein stability and abolishes tendency to form polymers. No effect on inhibitory activity. L->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285087;Dbxref=PMID:19285087
SERPINI1	Q99574	160	225	162	162	Mutagenesis	Note=Increases protein stability and abolishes tendency to form polymers. No effect on inhibitory activity. L->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285087;Dbxref=PMID:19285087
SERPINI1	Q99574	160	225	163	163	Mutagenesis	Note=Increases protein stability and decreases tendency to form polymers. No effect on inhibitory activity. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285087;Dbxref=PMID:19285087
SERPINI1	Q99574	160	225	163	163	Mutagenesis	Note=Increases protein stability and decreases tendency to form polymers. No effect on inhibitory activity. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285087;Dbxref=PMID:19285087
SERPINI1	Q99574	160	225	158	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	158	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	169	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	169	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	176	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	176	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	200	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	200	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	211	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
SERPINI1	Q99574	160	225	211	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F02
NKTR	P30414	80	95	1	1462	Chain	ID=PRO_0000064217;Note=NK-tumor recognition protein
NKTR	P30414	125	134	1	1462	Chain	ID=PRO_0000064217;Note=NK-tumor recognition protein
NKTR	P30414	80	95	10	175	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
NKTR	P30414	125	134	10	175	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
NKTR	P30414	80	95	78	80	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE9
NKTR	P30414	80	95	81	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE9
NKTR	P30414	125	134	123	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE9
NKTR	P30414	125	134	131	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE9
NKTR	P30414	125	134	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HE9
NOD2	Q9HC29	849	876	1	1040	Chain	ID=PRO_0000004418;Note=Nucleotide-binding oligomerization domain-containing protein 2
NOD2	Q9HC29	877	904	1	1040	Chain	ID=PRO_0000004418;Note=Nucleotide-binding oligomerization domain-containing protein 2
NOD2	Q9HC29	849	876	844	865	Repeat	Note=LRR 3
NOD2	Q9HC29	849	876	872	884	Repeat	Note=LRR 4
NOD2	Q9HC29	877	904	872	884	Repeat	Note=LRR 4
NOD2	Q9HC29	877	904	900	920	Repeat	Note=LRR 5
NOD2	Q9HC29	849	876	225	1040	Alternative sequence	ID=VSP_046568;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20698950;Dbxref=PMID:20698950
NOD2	Q9HC29	877	904	225	1040	Alternative sequence	ID=VSP_046568;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20698950;Dbxref=PMID:20698950
NOD2	Q9HC29	849	876	849	849	Natural variant	ID=VAR_073248;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16485124;Dbxref=dbSNP:rs104895486,PMID:16485124
NOD2	Q9HC29	849	876	852	852	Natural variant	ID=VAR_073249;Note=In IBD1%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15024686;Dbxref=dbSNP:rs104895467,PMID:15024686
NOD2	Q9HC29	849	876	853	853	Natural variant	ID=VAR_012698;Note=In IBD1%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11385576;Dbxref=dbSNP:rs104895446,PMID:11385576
NOD2	Q9HC29	849	876	863	863	Natural variant	ID=VAR_012699;Note=In IBD1%3B unknown pathological significance. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11385576;Dbxref=dbSNP:rs104895447,PMID:11385576
NOD2	Q9HC29	877	904	885	885	Natural variant	ID=VAR_012700;Note=In IBD1%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11385576;Dbxref=PMID:11385576
NOM1	Q5C9Z4	722	766	1	860	Chain	ID=PRO_0000286823;Note=Nucleolar MIF4G domain-containing protein 1
NOM1	Q5C9Z4	722	766	654	770	Domain	Note=MI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
NOM1	Q5C9Z4	722	766	723	723	Natural variant	ID=VAR_053051;Note=M->V;Dbxref=dbSNP:rs12919
NOMO3	P69849	245	291	32	1222	Chain	ID=PRO_0000021821;Note=Nodal modulator 3
NOMO3	P69849	1009	1037	32	1222	Chain	ID=PRO_0000021821;Note=Nodal modulator 3
NOMO3	P69849	1074	1108	32	1222	Chain	ID=PRO_0000021821;Note=Nodal modulator 3
NOMO3	P69849	1108	1148	32	1222	Chain	ID=PRO_0000021821;Note=Nodal modulator 3
NOMO3	P69849	245	291	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO3	P69849	1009	1037	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO3	P69849	1074	1108	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO3	P69849	1108	1148	32	1155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO3	P69849	1108	1148	1141	1141	Sequence conflict	Note=I->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
GTPBP4	Q9BZE4	218	282	2	634	Chain	ID=PRO_0000195023;Note=Nucleolar GTP-binding protein 1
GTPBP4	Q9BZE4	282	304	2	634	Chain	ID=PRO_0000195023;Note=Nucleolar GTP-binding protein 1
GTPBP4	Q9BZE4	304	334	2	634	Chain	ID=PRO_0000195023;Note=Nucleolar GTP-binding protein 1
GTPBP4	Q9BZE4	371	397	2	634	Chain	ID=PRO_0000195023;Note=Nucleolar GTP-binding protein 1
GTPBP4	Q9BZE4	536	584	2	634	Chain	ID=PRO_0000195023;Note=Nucleolar GTP-binding protein 1
GTPBP4	Q9BZE4	218	282	169	340	Domain	Note=OBG-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
GTPBP4	Q9BZE4	282	304	169	340	Domain	Note=OBG-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
GTPBP4	Q9BZE4	304	334	169	340	Domain	Note=OBG-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
GTPBP4	Q9BZE4	218	282	221	225	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
GTPBP4	Q9BZE4	282	304	289	292	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
GTPBP4	Q9BZE4	536	584	558	558	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
GTPBP4	Q9BZE4	304	334	332	332	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
NOSTRIN	Q8IVI9	38	65	1	506	Chain	ID=PRO_0000289089;Note=Nostrin
NOSTRIN	Q8IVI9	114	135	1	506	Chain	ID=PRO_0000289089;Note=Nostrin
NOSTRIN	Q8IVI9	135	168	1	506	Chain	ID=PRO_0000289089;Note=Nostrin
NOSTRIN	Q8IVI9	168	210	1	506	Chain	ID=PRO_0000289089;Note=Nostrin
NOSTRIN	Q8IVI9	351	393	1	506	Chain	ID=PRO_0000289089;Note=Nostrin
NOSTRIN	Q8IVI9	38	65	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
NOSTRIN	Q8IVI9	114	135	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
NOSTRIN	Q8IVI9	135	168	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
NOSTRIN	Q8IVI9	168	210	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
NOSTRIN	Q8IVI9	351	393	292	372	Domain	Note=REM-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01207
NOSTRIN	Q8IVI9	135	168	160	222	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NOSTRIN	Q8IVI9	168	210	160	222	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NOSTRIN	Q8IVI9	114	135	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5I0D6
NOSTRIN	Q8IVI9	38	65	1	78	Alternative sequence	ID=VSP_025884;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NOSTRIN	Q8IVI9	38	65	38	65	Alternative sequence	ID=VSP_025885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NOSTRIN	Q8IVI9	168	210	209	209	Alternative sequence	ID=VSP_044995;Note=In isoform 4. Y->YQVTHSICLYAFWVKRAWGKCVSDLRYQDTFLPGNLPPLWFGYDIVKRLIMRLCSVCL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAP1L1	P55209	363	380	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	312	353	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	143	186	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	116	143	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	363	380	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	312	353	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	143	186	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	116	143	2	388	Chain	ID=PRO_0000185652;Note=Nucleosome assembly protein 1-like 1
NAP1L1	P55209	143	186	129	145	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	116	143	129	145	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	143	186	129	145	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	116	143	129	145	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	363	380	348	378	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	312	353	348	378	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	363	380	348	378	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	312	353	348	378	Compositional bias	Note=Asp/Glu-rich (acidic)
NAP1L1	P55209	116	143	116	116	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NAP1L1	P55209	116	143	116	116	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NAP1L1	P55209	143	186	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NAP1L1	P55209	116	143	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NAP1L1	P55209	143	186	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NAP1L1	P55209	116	143	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NAP1L1	P55209	143	186	117	143	Alternative sequence	ID=VSP_057358;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAP1L1	P55209	116	143	117	143	Alternative sequence	ID=VSP_057358;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAP1L1	P55209	143	186	117	143	Alternative sequence	ID=VSP_057358;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAP1L1	P55209	116	143	117	143	Alternative sequence	ID=VSP_057358;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAP1L1	P55209	363	380	364	391	Alternative sequence	ID=VSP_053909;Note=In isoform 2. EGEEEGDEENDPDYDPKKDQNPAECKQQ->VMFTK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAP1L1	P55209	363	380	364	391	Alternative sequence	ID=VSP_053909;Note=In isoform 2. EGEEEGDEENDPDYDPKKDQNPAECKQQ->VMFTK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFXL1	Q6ZNB6	807	836	1	911	Chain	ID=PRO_0000278827;Note=NF-X1-type zinc finger protein NFXL1
NFXL1	Q6ZNB6	807	836	1	911	Chain	ID=PRO_0000278827;Note=NF-X1-type zinc finger protein NFXL1
NFXL1	Q6ZNB6	807	836	822	873	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NFXL1	Q6ZNB6	807	836	822	873	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NFXL1	Q6ZNB6	807	836	734	911	Alternative sequence	ID=VSP_023411;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NFXL1	Q6ZNB6	807	836	734	911	Alternative sequence	ID=VSP_023411;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM129C	Q86XR2	173	229	1	697	Chain	ID=PRO_0000323759;Note=Niban-like protein 2
FAM129C	Q86XR2	513	549	1	697	Chain	ID=PRO_0000323759;Note=Niban-like protein 2
FAM129C	Q86XR2	586	614	1	697	Chain	ID=PRO_0000323759;Note=Niban-like protein 2
FAM129C	Q86XR2	173	229	1	274	Alternative sequence	ID=VSP_054124;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM129C	Q86XR2	513	549	513	548	Alternative sequence	ID=VSP_032126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM129C	Q86XR2	586	614	550	593	Alternative sequence	ID=VSP_032127;Note=In isoform 5. ELPEFEGDVLAVGSQALTTEGIYEDVIRGCLLQRIDQELKKTLG->TESRSVAQAVVQWCDLGSLRPPPPRFKRSSHLGLPSSWDYRHPL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
FAM129C	Q86XR2	586	614	587	614	Alternative sequence	ID=VSP_054126;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM129C	Q86XR2	586	614	594	697	Alternative sequence	ID=VSP_032128;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
FAM129C	Q86XR2	173	229	229	229	Natural variant	ID=VAR_039583;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12693554,ECO:0000269|PubMed:12886250,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs8107859,PMID:12693554,PMID:12886250,PMID:14702039,PMID:15489334
FAM129C	Q86XR2	513	549	543	543	Natural variant	ID=VAR_039584;Note=L->F;Dbxref=dbSNP:rs10401716
FAM129C	Q86XR2	586	614	603	603	Natural variant	ID=VAR_039585;Note=G->S;Dbxref=dbSNP:rs11666267
NCSTN	Q92542	281	332	34	709	Chain	ID=PRO_0000019681;Note=Nicastrin
NCSTN	Q92542	332	367	34	709	Chain	ID=PRO_0000019681;Note=Nicastrin
NCSTN	Q92542	485	517	34	709	Chain	ID=PRO_0000019681;Note=Nicastrin
NCSTN	Q92542	598	669	34	709	Chain	ID=PRO_0000019681;Note=Nicastrin
NCSTN	Q92542	281	332	34	669	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:26280335,ECO:0000305|PubMed:26776682;Dbxref=PMID:26280335,PMID:26776682
NCSTN	Q92542	332	367	34	669	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:26280335,ECO:0000305|PubMed:26776682;Dbxref=PMID:26280335,PMID:26776682
NCSTN	Q92542	485	517	34	669	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:26280335,ECO:0000305|PubMed:26776682;Dbxref=PMID:26280335,PMID:26776682
NCSTN	Q92542	598	669	34	669	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:26280335,ECO:0000305|PubMed:26776682;Dbxref=PMID:26280335,PMID:26776682
NCSTN	Q92542	485	517	506	506	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5A63,ECO:0000255,ECO:0000269|PubMed:26280335;Dbxref=PMID:26280335
NCSTN	Q92542	598	669	612	612	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
NCSTN	Q92542	598	669	586	620	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5A63,ECO:0000244|PDB:5FN2,ECO:0000244|PDB:5FN3,ECO:0000244|PDB:5FN4,ECO:0000244|PDB:5FN5,ECO:0000269|PubMed:26280335,ECO:0000269|PubMed:26623517;Dbxref=PMID:26280335,PMID:26623517
NCSTN	Q92542	332	367	336	337	Mutagenesis	Note=Increases production of amyloid-beta (beta-APP40 and beta-APP42) in APP processing. DY->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10993067;Dbxref=PMID:10993067
NCSTN	Q92542	598	669	657	657	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCSTN	Q92542	281	332	275	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	281	332	287	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	281	332	295	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	281	332	299	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	281	332	322	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	332	367	333	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	332	367	340	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	332	367	352	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	332	367	356	358	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	332	367	359	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	485	517	482	502	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	485	517	508	510	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	485	517	515	526	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	597	599	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	601	605	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	611	614	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	619	623	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	627	630	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	633	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	643	645	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	649	651	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	657	664	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
NCSTN	Q92542	598	669	666	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
KLRK1	P26718	80	92	1	216	Chain	ID=PRO_0000046665;Note=NKG2-D type II integral membrane protein
KLRK1	P26718	80	92	1	216	Chain	ID=PRO_0000046665;Note=NKG2-D type II integral membrane protein
KLRK1	P26718	80	92	73	216	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRK1	P26718	80	92	73	216	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOB1	Q9ULX3	109	133	2	412	Chain	ID=PRO_0000233265;Note=RNA-binding protein NOB1
NIPSNAP3B	Q9BS92	143	193	1	247	Chain	ID=PRO_0000221154;Note=Protein NipSnap homolog 3B
NIPSNAP3B	Q9BS92	143	193	154	154	Natural variant	ID=VAR_050278;Note=K->E;Dbxref=dbSNP:rs3739740
NIPSNAP3B	Q9BS92	143	193	159	159	Natural variant	ID=VAR_050279;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3739741,PMID:14702039
NIPSNAP3B	Q9BS92	143	193	190	190	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPAS3	Q8IXF0	17	46	1	933	Chain	ID=PRO_0000127408;Note=Neuronal PAS domain-containing protein 3
NPAS3	Q8IXF0	156	186	1	933	Chain	ID=PRO_0000127408;Note=Neuronal PAS domain-containing protein 3
NPAS3	Q8IXF0	156	186	147	217	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
NPAS3	Q8IXF0	17	46	1	102	Alternative sequence	ID=VSP_009084;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12746393;Dbxref=PMID:12746393
NPAS3	Q8IXF0	17	46	18	47	Alternative sequence	ID=VSP_009085;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12746393,ECO:0000303|Ref.1,ECO:0000303|Ref.2;Dbxref=PMID:12746393
SLC17A1	Q14916	245	299	1	467	Chain	ID=PRO_0000220936;Note=Sodium-dependent phosphate transport protein 1
SLC17A1	Q14916	176	205	1	467	Chain	ID=PRO_0000220936;Note=Sodium-dependent phosphate transport protein 1
SLC17A1	Q14916	245	299	1	467	Chain	ID=PRO_0000220936;Note=Sodium-dependent phosphate transport protein 1
SLC17A1	Q14916	176	205	1	467	Chain	ID=PRO_0000220936;Note=Sodium-dependent phosphate transport protein 1
SLC17A1	Q14916	176	205	178	198	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A1	Q14916	176	205	178	198	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A1	Q14916	176	205	200	220	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A1	Q14916	176	205	200	220	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A1	Q14916	245	299	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A1	Q14916	245	299	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A1	Q14916	245	299	246	299	Alternative sequence	ID=VSP_035012;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SLC17A1	Q14916	245	299	246	299	Alternative sequence	ID=VSP_035012;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SLC17A1	Q14916	245	299	269	269	Natural variant	ID=VAR_050061;Note=Increased urate transport. T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27906618,ECO:0000269|PubMed:7826357,ECO:0000269|PubMed:8288239;Dbxref=dbSNP:rs1165196,PMID:27906618,PMID:7826357,PMID:8288239
SLC17A1	Q14916	245	299	269	269	Natural variant	ID=VAR_050061;Note=Increased urate transport. T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27906618,ECO:0000269|PubMed:7826357,ECO:0000269|PubMed:8288239;Dbxref=dbSNP:rs1165196,PMID:27906618,PMID:7826357,PMID:8288239
NEBL	O76041	870	920	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	716	747	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	592	623	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	446	483	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	372	409	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	266	301	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	160	194	1	1014	Chain	ID=PRO_0000096774;Note=Nebulette
NEBL	O76041	160	194	137	172	Repeat	Note=Nebulin 4
NEBL	O76041	160	194	173	205	Repeat	Note=Nebulin 5
NEBL	O76041	266	301	242	278	Repeat	Note=Nebulin 7
NEBL	O76041	266	301	279	313	Repeat	Note=Nebulin 8
NEBL	O76041	372	409	349	385	Repeat	Note=Nebulin 10
NEBL	O76041	372	409	386	422	Repeat	Note=Nebulin 11
NEBL	O76041	446	483	423	459	Repeat	Note=Nebulin 12
NEBL	O76041	446	483	460	496	Repeat	Note=Nebulin 13
NEBL	O76041	592	623	570	599	Repeat	Note=Nebulin 16
NEBL	O76041	592	623	600	635	Repeat	Note=Nebulin 17
NEBL	O76041	716	747	694	728	Repeat	Note=Nebulin 20
NEBL	O76041	716	747	729	759	Repeat	Note=Nebulin 21
NEBL	O76041	870	920	836	953	Region	Note=Linker
NEBL	O76041	592	623	1	664	Alternative sequence	ID=VSP_043816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	446	483	1	664	Alternative sequence	ID=VSP_043816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	372	409	1	664	Alternative sequence	ID=VSP_043816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	266	301	1	664	Alternative sequence	ID=VSP_043816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	160	194	1	664	Alternative sequence	ID=VSP_043816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	716	747	665	782	Alternative sequence	ID=VSP_043817;Note=In isoform 2. TPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISM->MNPQCARCGKVVYPTEKVNCLDKYWHKGCFHCEVCKMALNMNNYKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISN;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	870	920	840	920	Alternative sequence	ID=VSP_043818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15004028,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15004028,PMID:15489334
NEBL	O76041	160	194	187	187	Natural variant	ID=VAR_010289;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11140941;Dbxref=dbSNP:rs75301590,PMID:11140941
NEBL	O76041	372	409	378	378	Natural variant	ID=VAR_051229;Note=D->H;Dbxref=dbSNP:rs41277370
NEBL	O76041	716	747	728	728	Natural variant	ID=VAR_010292;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11140941;Dbxref=dbSNP:rs71535732,PMID:11140941
NEBL	O76041	716	747	706	726	Sequence conflict	Note=RAKENQKNISNVYYRGQLGRA->PKETRKTSACLLQSSAGES;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEBL	O76041	716	747	732	732	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEBL	O76041	716	747	740	740	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEBL	O76041	716	747	743	743	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEBL	O76041	870	920	902	904	Sequence conflict	Note=EIY->RDL;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEGR1	Q7Z3B1	178	222	38	324	Chain	ID=PRO_0000015037;Note=Neuronal growth regulator 1
NEGR1	Q7Z3B1	136	178	38	324	Chain	ID=PRO_0000015037;Note=Neuronal growth regulator 1
NEGR1	Q7Z3B1	178	222	139	221	Domain	Note=Ig-like C2-type 2
NEGR1	Q7Z3B1	136	178	139	221	Domain	Note=Ig-like C2-type 2
NEGR1	Q7Z3B1	178	222	187	187	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80Z24
NEGR1	Q7Z3B1	136	178	155	155	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEGR1	Q7Z3B1	178	222	160	203	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NEGR1	Q7Z3B1	136	178	160	203	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NEGR1	Q7Z3B1	136	178	169	169	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEGR1	Q7Z3B1	178	222	208	208	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEK9	Q8TD19	814	868	2	979	Chain	ID=PRO_0000086435;Note=Serine/threonine-protein kinase Nek9
NEK9	Q8TD19	724	744	2	979	Chain	ID=PRO_0000086435;Note=Serine/threonine-protein kinase Nek9
NEK9	Q8TD19	724	744	669	726	Repeat	Note=RCC1 6
NEK9	Q8TD19	814	868	732	891	Region	Note=Interaction with NEK6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19001501;Dbxref=PMID:19001501
NEK9	Q8TD19	724	744	732	891	Region	Note=Interaction with NEK6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19001501;Dbxref=PMID:19001501
NEK9	Q8TD19	814	868	765	888	Compositional bias	Note=Pro/Ser/Thr-rich
NEK9	Q8TD19	724	744	741	741	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
NEK9	Q8TD19	814	868	832	832	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
NEK9	Q8TD19	814	868	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NEK9	Q8TD19	814	868	828	828	Natural variant	ID=VAR_040926;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36014869,PMID:17344846
NLRC3	Q7RTR2	895	922	1	1065	Chain	ID=PRO_0000296187;Note=NLR family CARD domain-containing protein 3
NLRC3	Q7RTR2	895	922	889	912	Repeat	Note=LRR 11
NLRC3	Q7RTR2	895	922	917	940	Repeat	Note=LRR 12
NLRC3	Q7RTR2	895	922	762	1065	Alternative sequence	ID=VSP_027137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
NLRC3	Q7RTR2	895	922	869	896	Alternative sequence	ID=VSP_027138;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
NMUR2	Q9GZQ4	270	312	1	415	Chain	ID=PRO_0000069910;Note=Neuromedin-U receptor 2
NMUR2	Q9GZQ4	270	312	266	286	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
NMUR2	Q9GZQ4	270	312	287	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NMUR2	Q9GZQ4	270	312	302	322	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
NMUR2	Q9GZQ4	270	312	298	298	Natural variant	ID=VAR_023941;Note=S->T;Dbxref=dbSNP:rs4958535
NIT2	Q9NQR4	143	168	1	276	Chain	ID=PRO_0000320252;Note=Omega-amidase NIT2
NIT2	Q9NQR4	143	168	4	248	Domain	Note=CN hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00054
NIT2	Q9NQR4	143	168	153	153	Active site	Note=Nucleophile;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00054
NOL11	Q9H8H0	221	284	1	719	Chain	ID=PRO_0000096931;Note=Nucleolar protein 11
NOL11	Q9H8H0	381	406	1	719	Chain	ID=PRO_0000096931;Note=Nucleolar protein 11
NOL11	Q9H8H0	221	284	170	719	Alternative sequence	ID=VSP_053284;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOL11	Q9H8H0	381	406	170	719	Alternative sequence	ID=VSP_053284;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNL2	Q13823	381	434	1	731	Chain	ID=PRO_0000215806;Note=Nucleolar GTP-binding protein 2
GNL2	Q13823	265	303	1	731	Chain	ID=PRO_0000215806;Note=Nucleolar GTP-binding protein 2
GNL2	Q13823	265	303	207	368	Domain	Note=CP-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01058
GNL2	Q13823	265	303	284	284	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
DRAP1	Q14919	70	109	2	205	Chain	ID=PRO_0000080001;Note=Dr1-associated corepressor
DRAP1	Q14919	70	109	14	77	Domain	Note=Histone-fold
DRAP1	Q14919	70	109	67	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JFI
NDST1	P52848	479	522	1	882	Chain	ID=PRO_0000085210;Note=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
NDST1	P52848	715	772	1	882	Chain	ID=PRO_0000085210;Note=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
NDST1	P52848	479	522	40	882	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NDST1	P52848	715	772	40	882	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NDST1	P52848	479	522	40	598	Region	Note=Heparan sulfate N-deacetylase 1
NDST1	P52848	715	772	599	882	Region	Note=Heparan sulfate N-sulfotransferase 1
NDST1	P52848	715	772	557	882	Alternative sequence	ID=VSP_017398;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NDST1	P52848	715	772	743	743	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NDST1	P52848	715	772	706	719	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NDST1	P52848	715	772	723	727	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NDST1	P52848	715	772	730	734	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NDST1	P52848	715	772	742	752	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NDST1	P52848	715	772	753	755	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NDST1	P52848	715	772	757	765	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NDST1	P52848	715	772	770	772	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NST
NECAB2	Q7Z6G3	265	283	1	386	Chain	ID=PRO_0000282613;Note=N-terminal EF-hand calcium-binding protein 2
NECAB2	Q7Z6G3	321	346	1	386	Chain	ID=PRO_0000282613;Note=N-terminal EF-hand calcium-binding protein 2
NECAB2	Q7Z6G3	321	346	286	375	Domain	Note=ABM
NEO1	Q92859	149	241	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	697	734	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	1053	1064	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	1064	1087	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	1247	1300	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	149	241	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	697	734	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	1053	1064	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	1064	1087	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	1247	1300	34	1461	Chain	ID=PRO_0000015043;Note=Neogenin
NEO1	Q92859	149	241	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	697	734	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	1053	1064	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	1064	1087	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	149	241	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	697	734	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	1053	1064	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	1064	1087	34	1105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	1247	1300	1127	1461	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	1247	1300	1127	1461	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	149	241	152	238	Domain	Note=Ig-like C2-type 2
NEO1	Q92859	149	241	152	238	Domain	Note=Ig-like C2-type 2
NEO1	Q92859	697	734	636	731	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NEO1	Q92859	697	734	636	731	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NEO1	Q92859	1053	1064	957	1054	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NEO1	Q92859	1053	1064	957	1054	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NEO1	Q92859	149	241	210	210	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973;Dbxref=PMID:16335952,PMID:19349973
NEO1	Q92859	149	241	210	210	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973;Dbxref=PMID:16335952,PMID:19349973
NEO1	Q92859	697	734	715	715	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	697	734	715	715	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NEO1	Q92859	149	241	173	221	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NEO1	Q92859	149	241	173	221	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NEO1	Q92859	1053	1064	1054	1064	Alternative sequence	ID=VSP_047134;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEO1	Q92859	1064	1087	1054	1064	Alternative sequence	ID=VSP_047134;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEO1	Q92859	1053	1064	1054	1064	Alternative sequence	ID=VSP_047134;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEO1	Q92859	1064	1087	1054	1064	Alternative sequence	ID=VSP_047134;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEO1	Q92859	1247	1300	1248	1301	Alternative sequence	ID=VSP_043330;Note=In isoform 3. PVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTE->Q;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEO1	Q92859	1247	1300	1248	1301	Alternative sequence	ID=VSP_043330;Note=In isoform 3. PVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTE->Q;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEO1	Q92859	1247	1300	1248	1300	Alternative sequence	ID=VSP_002593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9121761,ECO:0000303|PubMed:9169140;Dbxref=PMID:9121761,PMID:9169140
NEO1	Q92859	1247	1300	1248	1300	Alternative sequence	ID=VSP_002593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9121761,ECO:0000303|PubMed:9169140;Dbxref=PMID:9121761,PMID:9169140
NEO1	Q92859	149	241	168	168	Sequence conflict	Note=N->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEO1	Q92859	149	241	168	168	Sequence conflict	Note=N->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEO1	Q92859	697	734	693	697	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	693	697	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	704	708	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	704	708	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	710	713	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	710	713	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	716	720	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	716	720	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	724	727	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NEO1	Q92859	697	734	724	727	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5H
NKAP	Q8N5F7	308	357	1	415	Chain	ID=PRO_0000259645;Note=NF-kappa-B-activating protein
NKAP	Q8N5F7	129	155	1	415	Chain	ID=PRO_0000259645;Note=NF-kappa-B-activating protein
NKAP	Q8N5F7	308	357	273	415	Region	Note=Necessary for interaction with HDAC3 and transcriptional repression;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19409814;Dbxref=PMID:19409814
NKAP	Q8N5F7	129	155	149	149	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
NIT1	Q86X76	1	32	1	13	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIT1	Q86X76	1	32	14	327	Chain	ID=PRO_0000213251;Note=Deaminated glutathione amidase;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIT1	Q86X76	1	32	1	36	Alternative sequence	ID=VSP_011546;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9671749;Dbxref=PMID:9671749
NIT1	Q86X76	1	32	1	33	Alternative sequence	ID=VSP_011545;Note=In isoform 5. MLGFITRPPHRFLSLLCPGLRIPQLSVLCAQPR->MTFGLRKRLSEERGFSLM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9671749;Dbxref=PMID:9671749
NIT1	Q86X76	1	32	1	31	Alternative sequence	ID=VSP_011544;Note=In isoform 4. MLGFITRPPHRFLSLLCPGLRIPQLSVLCAQ->MVLAISSCWASSPGLLTDSCPFCVLDSGYLNSQYFVLSPGRTYSLSRR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9671749;Dbxref=PMID:9671749
NMNAT2	Q9BZQ4	149	176	1	307	Chain	ID=PRO_0000135014;Note=Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
NMNAT2	Q9BZQ4	149	176	164	164	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BNJ3
NMNAT2	Q9BZQ4	149	176	165	165	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BNJ3
NLRP6	P59044	702	733	1	892	Chain	ID=PRO_0000080892;Note=NACHT%2C LRR and PYD domains-containing protein 6
NLRP6	P59044	734	790	1	892	Chain	ID=PRO_0000080892;Note=NACHT%2C LRR and PYD domains-containing protein 6
NLRP6	P59044	702	733	727	747	Repeat	Note=LRR 2
NLRP6	P59044	734	790	727	747	Repeat	Note=LRR 2
NLRP6	P59044	734	790	755	778	Repeat	Note=LRR 3
NLRP6	P59044	702	733	702	702	Alternative sequence	ID=VSP_054400;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NLRP6	P59044	702	733	713	713	Natural variant	ID=VAR_079497;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26282398;Dbxref=dbSNP:rs966612159,PMID:26282398
NOP2	P46087	479	520	1	812	Chain	ID=PRO_0000211818;Note=Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
NOP2	P46087	479	520	1	812	Chain	ID=PRO_0000211818;Note=Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
NOP2	P46087	479	520	517	517	Active site	Note=Nucleophile;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01023
NOP2	P46087	479	520	517	517	Active site	Note=Nucleophile;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01023
PMS2	P54278	669	724	1	862	Chain	ID=PRO_0000178005;Note=Mismatch repair endonuclease PMS2
PMS2	P54278	329	381	1	862	Chain	ID=PRO_0000178005;Note=Mismatch repair endonuclease PMS2
PMS2	P54278	179	235	1	862	Chain	ID=PRO_0000178005;Note=Mismatch repair endonuclease PMS2
PMS2	P54278	179	235	180	183	Alternative sequence	ID=VSP_029384;Note=In isoform 4. EYAK->QASV;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	669	724	184	862	Alternative sequence	ID=VSP_029385;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	329	381	184	862	Alternative sequence	ID=VSP_029385;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	179	235	184	862	Alternative sequence	ID=VSP_029385;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	669	724	269	669	Alternative sequence	ID=VSP_029386;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	329	381	269	669	Alternative sequence	ID=VSP_029386;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	669	724	573	862	Alternative sequence	ID=VSP_029388;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS2	P54278	179	235	182	182	Natural variant	ID=VAR_078523;Note=In HNPCC4%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16619239;Dbxref=dbSNP:rs587779341,PMID:16619239
PMS2	P54278	179	235	205	205	Natural variant	ID=VAR_078524;Note=In MMRCS and HNPCC4%3B unknown pathological significance%3B normal DNA mismatch repair activity. Q->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18602922,ECO:0000269|PubMed:24027009,ECO:0000269|PubMed:27435373;Dbxref=dbSNP:rs587779342,PMID:18602922,PMID:24027009,PMID:27435373
PMS2	P54278	179	235	207	207	Natural variant	ID=VAR_078525;Note=In HNPCC4%3B unknown pathological significance%3B normal DNA mismatch repair activity. G->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19479271,ECO:0000269|PubMed:24027009;Dbxref=dbSNP:rs374704824,PMID:19479271,PMID:24027009
PMS2	P54278	669	724	699	699	Natural variant	ID=VAR_079819;Note=Polymorphism%3B no effect on protein levels. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28494185;Dbxref=dbSNP:rs587781317,PMID:28494185
PMS2	P54278	669	724	705	705	Natural variant	ID=VAR_012974;Note=In MMRCS and HNPCC4%3B decreases DNA mismatch repair activity. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18602922,ECO:0000269|PubMed:24027009,ECO:0000269|PubMed:9419979;Dbxref=dbSNP:rs267608161,PMID:18602922,PMID:24027009,PMID:9419979
PMS2	P54278	179	235	177	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	179	235	199	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	179	235	211	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	179	235	223	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	179	235	233	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	329	381	329	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	329	381	332	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	329	381	343	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
PMS2	P54278	329	381	348	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7S
NEK10	Q6ZWH5	1003	1013	1	1172	Chain	ID=PRO_0000259767;Note=Serine/threonine-protein kinase Nek10
NEK10	Q6ZWH5	956	1003	1	1172	Chain	ID=PRO_0000259767;Note=Serine/threonine-protein kinase Nek10
NEK10	Q6ZWH5	535	581	1	1172	Chain	ID=PRO_0000259767;Note=Serine/threonine-protein kinase Nek10
NEK10	Q6ZWH5	239	267	1	1172	Chain	ID=PRO_0000259767;Note=Serine/threonine-protein kinase Nek10
NEK10	Q6ZWH5	239	267	209	251	Repeat	Note=ARM
NEK10	Q6ZWH5	535	581	519	712	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK10	Q6ZWH5	535	581	548	548	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK10	Q6ZWH5	535	581	1	688	Alternative sequence	ID=VSP_035688;Note=In isoform 5%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
NEK10	Q6ZWH5	239	267	1	688	Alternative sequence	ID=VSP_035688;Note=In isoform 5%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
NEK10	Q6ZWH5	1003	1013	219	1172	Alternative sequence	ID=VSP_021535;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEK10	Q6ZWH5	956	1003	219	1172	Alternative sequence	ID=VSP_021535;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEK10	Q6ZWH5	535	581	219	1172	Alternative sequence	ID=VSP_021535;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEK10	Q6ZWH5	239	267	219	1172	Alternative sequence	ID=VSP_021535;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEK10	Q6ZWH5	1003	1013	713	1172	Alternative sequence	ID=VSP_035691;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEK10	Q6ZWH5	956	1003	713	1172	Alternative sequence	ID=VSP_035691;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NEK10	Q6ZWH5	1003	1013	726	1172	Alternative sequence	ID=VSP_035692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NEK10	Q6ZWH5	956	1003	726	1172	Alternative sequence	ID=VSP_035692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NEK10	Q6ZWH5	1003	1013	957	1013	Alternative sequence	ID=VSP_035693;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NEK10	Q6ZWH5	956	1003	957	1013	Alternative sequence	ID=VSP_035693;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
NEK10	Q6ZWH5	1003	1013	1004	1013	Alternative sequence	ID=VSP_035694;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEK10	Q6ZWH5	239	267	239	239	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEK11	Q8NG66	216	265	1	645	Chain	ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11
NEK11	Q8NG66	392	428	1	645	Chain	ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11
NEK11	Q8NG66	216	265	1	645	Chain	ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11
NEK11	Q8NG66	392	428	1	645	Chain	ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11
NEK11	Q8NG66	216	265	29	287	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK11	Q8NG66	216	265	29	287	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK11	Q8NG66	216	265	263	263	Natural variant	ID=VAR_040938;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35567155,PMID:17344846
NEK11	Q8NG66	216	265	263	263	Natural variant	ID=VAR_040938;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35567155,PMID:17344846
NEK4	P51957	456	502	1	841	Chain	ID=PRO_0000086425;Note=Serine/threonine-protein kinase Nek4
NEK4	P51957	186	222	1	841	Chain	ID=PRO_0000086425;Note=Serine/threonine-protein kinase Nek4
NEK4	P51957	186	222	6	261	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NEK4	P51957	456	502	461	461	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NEK4	P51957	456	502	457	502	Alternative sequence	ID=VSP_037123;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEK4	P51957	456	502	456	456	Natural variant	ID=VAR_040919;Note=Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56019351,PMID:17344846
NFE2L2	Q16236	134	198	1	605	Chain	ID=PRO_0000076449;Note=Nuclear factor erythroid 2-related factor 2
NFE2L2	Q16236	104	134	1	605	Chain	ID=PRO_0000076449;Note=Nuclear factor erythroid 2-related factor 2
NFE2L2	Q16236	134	198	135	141	Alternative sequence	ID=VSP_046168;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFE2L2	Q16236	134	198	178	178	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFKB1	P19838	52	85	1	968	Chain	ID=PRO_0000030310;Note=Nuclear factor NF-kappa-B p105 subunit
NFKB1	P19838	189	242	1	968	Chain	ID=PRO_0000030310;Note=Nuclear factor NF-kappa-B p105 subunit
NFKB1	P19838	52	85	1	968	Chain	ID=PRO_0000030310;Note=Nuclear factor NF-kappa-B p105 subunit
NFKB1	P19838	189	242	1	968	Chain	ID=PRO_0000030310;Note=Nuclear factor NF-kappa-B p105 subunit
NFKB1	P19838	52	85	1	433	Chain	ID=PRO_0000030311;Note=Nuclear factor NF-kappa-B p50 subunit
NFKB1	P19838	189	242	1	433	Chain	ID=PRO_0000030311;Note=Nuclear factor NF-kappa-B p50 subunit
NFKB1	P19838	52	85	1	433	Chain	ID=PRO_0000030311;Note=Nuclear factor NF-kappa-B p50 subunit
NFKB1	P19838	189	242	1	433	Chain	ID=PRO_0000030311;Note=Nuclear factor NF-kappa-B p50 subunit
NFKB1	P19838	52	85	42	367	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
NFKB1	P19838	189	242	42	367	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
NFKB1	P19838	52	85	42	367	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
NFKB1	P19838	189	242	42	367	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
NFKB1	P19838	52	85	61	61	Modified residue	Note=S-nitrosocysteine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8710491;Dbxref=PMID:8710491
NFKB1	P19838	52	85	61	61	Modified residue	Note=S-nitrosocysteine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8710491;Dbxref=PMID:8710491
NFKB1	P19838	52	85	61	61	Lipidation	Note=S-(15-deoxy-Delta12%2C14-prostaglandin J2-9-yl)cysteine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11466314;Dbxref=PMID:11466314
NFKB1	P19838	52	85	61	61	Lipidation	Note=S-(15-deoxy-Delta12%2C14-prostaglandin J2-9-yl)cysteine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11466314;Dbxref=PMID:11466314
NFKB1	P19838	52	85	1	180	Alternative sequence	ID=VSP_042869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFKB1	P19838	52	85	1	180	Alternative sequence	ID=VSP_042869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFKB1	P19838	189	242	181	189	Alternative sequence	ID=VSP_042870;Note=In isoform 3. EGGGDRQLG->MNGLCCMAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFKB1	P19838	189	242	181	189	Alternative sequence	ID=VSP_042870;Note=In isoform 3. EGGGDRQLG->MNGLCCMAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NFKB1	P19838	52	85	61	61	Mutagenesis	Note=Suppresses S-nitrosylation-induced inhibition of DNA-binding activity. Loss of S-(15-deoxy-Delta12%2C14-prostaglandin J2-9-yl)cysteine-induced inhibition of DNA-binding activity. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11466314,ECO:0000269|PubMed:8710491;Dbxref=PMID:11466314,PMID:8710491
NFKB1	P19838	52	85	61	61	Mutagenesis	Note=Suppresses S-nitrosylation-induced inhibition of DNA-binding activity. Loss of S-(15-deoxy-Delta12%2C14-prostaglandin J2-9-yl)cysteine-induced inhibition of DNA-binding activity. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11466314,ECO:0000269|PubMed:8710491;Dbxref=PMID:11466314,PMID:8710491
NFKB1	P19838	52	85	52	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	52	85	52	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	52	85	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	52	85	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	52	85	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	52	85	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	190	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	190	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	211	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	211	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	223	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	223	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	227	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	227	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	234	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
NFKB1	P19838	189	242	234	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SVC
FAM129B	Q96TA1	439	478	2	746	Chain	ID=PRO_0000213121;Note=Niban-like protein 1
FAM129B	Q96TA1	387	439	2	746	Chain	ID=PRO_0000213121;Note=Niban-like protein 1
FAM129B	Q96TA1	235	270	2	746	Chain	ID=PRO_0000213121;Note=Niban-like protein 1
TACR2	P21452	131	195	1	398	Chain	ID=PRO_0000069893;Note=Substance-K receptor
TACR2	P21452	131	195	130	149	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TACR2	P21452	131	195	150	170	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
TACR2	P21452	131	195	171	196	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TACR2	P21452	131	195	106	181	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00521
NLK	Q9UBE8	279	349	1	527	Chain	ID=PRO_0000186336;Note=Serine/threonine-protein kinase NLK
NLK	Q9UBE8	349	383	1	527	Chain	ID=PRO_0000186336;Note=Serine/threonine-protein kinase NLK
NLK	Q9UBE8	383	412	1	527	Chain	ID=PRO_0000186336;Note=Serine/threonine-protein kinase NLK
NLK	Q9UBE8	279	349	138	427	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NLK	Q9UBE8	349	383	138	427	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NLK	Q9UBE8	383	412	138	427	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NLK	Q9UBE8	279	349	1	304	Region	Note=Required for interaction with TAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
NLK	Q9UBE8	279	349	124	416	Region	Note=Sufficient for interaction with DAPK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454679;Dbxref=PMID:21454679
NLK	Q9UBE8	349	383	124	416	Region	Note=Sufficient for interaction with DAPK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454679;Dbxref=PMID:21454679
NLK	Q9UBE8	383	412	124	416	Region	Note=Sufficient for interaction with DAPK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454679;Dbxref=PMID:21454679
NLK	Q9UBE8	279	349	298	300	Motif	Note=TQE
NLK	Q9UBE8	279	349	298	298	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19369195,PMID:19690332,PMID:23186163
NLK	Q9UBE8	279	349	343	343	Natural variant	ID=VAR_042273;Note=In a glioblastoma multiforme sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
NDUFAF7	Q7L592	72	99	47	441	Chain	ID=PRO_0000315672;Note=Protein arginine methyltransferase NDUFAF7%2C mitochondrial
NDUFAF7	Q7L592	72	99	73	99	Alternative sequence	ID=VSP_030606;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NEB	P20929	6527	6576	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6368	6399	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6337	6368	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6306	6337	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6275	6306	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6244	6275	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6244	6275	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6182	6213	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6116	6151	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	6081	6116	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	5934	5971	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	5579	5614	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	5403	5438	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	523	558	1	6669	Chain	ID=PRO_0000096775;Note=Nebulin
NEB	P20929	523	558	502	532	Repeat	Note=Nebulin 12
NEB	P20929	523	558	537	567	Repeat	Note=Nebulin 13
NEB	P20929	5403	5438	5382	5412	Repeat	Note=Nebulin 147
NEB	P20929	5403	5438	5417	5447	Repeat	Note=Nebulin 148
NEB	P20929	5579	5614	5558	5588	Repeat	Note=Nebulin 152
NEB	P20929	5579	5614	5593	5623	Repeat	Note=Nebulin 153
NEB	P20929	5934	5971	5911	5943	Repeat	Note=Nebulin 162
NEB	P20929	5934	5971	5950	5980	Repeat	Note=Nebulin 163
NEB	P20929	6081	6116	6060	6090	Repeat	Note=Nebulin 166
NEB	P20929	6116	6151	6095	6125	Repeat	Note=Nebulin 167
NEB	P20929	6081	6116	6095	6125	Repeat	Note=Nebulin 167
NEB	P20929	6116	6151	6130	6160	Repeat	Note=Nebulin 168
NEB	P20929	6182	6213	6161	6191	Repeat	Note=Nebulin 169
NEB	P20929	6182	6213	6192	6222	Repeat	Note=Nebulin 170
NEB	P20929	6244	6275	6223	6253	Repeat	Note=Nebulin 171
NEB	P20929	6244	6275	6223	6253	Repeat	Note=Nebulin 171
NEB	P20929	6275	6306	6255	6284	Repeat	Note=Nebulin 172
NEB	P20929	6244	6275	6255	6284	Repeat	Note=Nebulin 172
NEB	P20929	6244	6275	6255	6284	Repeat	Note=Nebulin 172
NEB	P20929	6306	6337	6285	6315	Repeat	Note=Nebulin 173
NEB	P20929	6275	6306	6285	6315	Repeat	Note=Nebulin 173
NEB	P20929	6337	6368	6316	6346	Repeat	Note=Nebulin 174
NEB	P20929	6306	6337	6316	6346	Repeat	Note=Nebulin 174
NEB	P20929	6368	6399	6347	6377	Repeat	Note=Nebulin 175
NEB	P20929	6337	6368	6347	6377	Repeat	Note=Nebulin 175
NEB	P20929	6368	6399	6378	6408	Repeat	Note=Nebulin 176
NEB	P20929	6527	6576	6457	6612	Region	Note=Interaction with SVIL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18639526;Dbxref=PMID:18639526
NEB	P20929	5403	5438	5404	5436	Alternative sequence	ID=VSP_054447;Note=In isoform 2. KKYRADYEQRKDKYHLVVDEPRHLLAKTAGDQI->RKYKSSAKMFLQHGCNEILRPDMLTALYNSHMW;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEB	P20929	6244	6275	6272	6273	Alternative sequence	ID=VSP_054448;Note=In isoform 2 and isoform 3. NF->NFSSILYKENLSKGTPLPVTPEMERVKLNQENFSSVLYKENVGKGIPIPITPEMERVKHNQENFSSVLYKENLGTGIPIPITPEMQRVKHNQENLSSVLYKENMGKGTPLPVTPEMERVKHNQENISSVLYKENMGKGTPLPVTPEMERVKHNQENI;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEB	P20929	6244	6275	6272	6273	Alternative sequence	ID=VSP_054448;Note=In isoform 2 and isoform 3. NF->NFSSILYKENLSKGTPLPVTPEMERVKLNQENFSSVLYKENVGKGIPIPITPEMERVKHNQENFSSVLYKENLGTGIPIPITPEMQRVKHNQENLSSVLYKENMGKGTPLPVTPEMERVKHNQENISSVLYKENMGKGTPLPVTPEMERVKHNQENI;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEB	P20929	5934	5971	5934	5934	Natural variant	ID=VAR_021888;Note=G->E;Dbxref=dbSNP:rs3732309
NEB	P20929	6116	6151	6131	6131	Natural variant	ID=VAR_056953;Note=T->I;Dbxref=dbSNP:rs34368668
NEB	P20929	6527	6576	6546	6546	Natural variant	ID=VAR_056954;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7739042;Dbxref=dbSNP:rs1061305,PMID:7739042
NEB	P20929	5403	5438	5432	5433	Sequence conflict	Note=AG->RS;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEB	P20929	6275	6306	6289	6289	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
NDUFS6	O75380	62	103	29	124	Chain	ID=PRO_0000020020;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 6%2C mitochondrial
NDUFS6	O75380	62	103	98	98	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52503
NDUFS6	O75380	62	103	68	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS6	O75380	62	103	81	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS6	O75380	62	103	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS6	O75380	62	103	94	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS6	O75380	62	103	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NEIL3	Q8TAT5	209	234	2	605	Chain	ID=PRO_0000170910;Note=Endonuclease 8-like 3
NFX1	Q12986	459	482	1	1120	Chain	ID=PRO_0000055979;Note=Transcriptional repressor NF-X1
NFX1	Q12986	910	943	1	1120	Chain	ID=PRO_0000055979;Note=Transcriptional repressor NF-X1
NFX1	Q12986	459	482	453	471	Zinc finger	Note=NF-X1-type 1
NFX1	Q12986	910	943	834	1120	Alternative sequence	ID=VSP_033683;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFKB2	Q00653	48	81	1	900	Chain	ID=PRO_0000030321;Note=Nuclear factor NF-kappa-B p100 subunit
NFKB2	Q00653	330	372	1	900	Chain	ID=PRO_0000030321;Note=Nuclear factor NF-kappa-B p100 subunit
NFKB2	Q00653	48	81	1	454	Chain	ID=PRO_0000030322;Note=Nuclear factor NF-kappa-B p52 subunit
NFKB2	Q00653	330	372	1	454	Chain	ID=PRO_0000030322;Note=Nuclear factor NF-kappa-B p52 subunit
NFKB2	Q00653	48	81	38	343	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
NFKB2	Q00653	330	372	38	343	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
NFKB2	Q00653	330	372	346	377	Region	Note=GRR
NFKB2	Q00653	330	372	337	341	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NFKB2	Q00653	330	372	350	400	Compositional bias	Note=Gly-rich
NFKB2	Q00653	330	372	351	351	Natural variant	ID=VAR_022224;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7;Dbxref=dbSNP:rs45580031
NFKB2	Q00653	48	81	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A3Q
NFKB2	Q00653	48	81	56	58	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A3Q
NFKB2	Q00653	48	81	79	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A3Q
NFE2L3	Q9Y4A8	250	278	1	694	Chain	ID=PRO_0000076452;Note=Nuclear factor erythroid 2-related factor 3
NFATC3	Q12968	699	1035	2	1075	Chain	ID=PRO_0000205180;Note=Nuclear factor of activated T-cells%2C cytoplasmic 3
NFATC3	Q12968	699	1035	1032	1041	Motif	Note=Nuclear export signal
NFATC3	Q12968	699	1035	700	1075	Alternative sequence	ID=VSP_005598;Note=In isoform 5. VLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL->GTRSHDGLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7749981;Dbxref=PMID:7749981
NFATC3	Q12968	699	1035	717	1075	Alternative sequence	ID=VSP_005599;Note=In isoform 6. SLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL->TLPQTSRQTLLGSQPPSASPPTV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7749981;Dbxref=PMID:7749981
NFATC3	Q12968	699	1035	702	702	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	702	702	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	702	702	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	831	831	Sequence conflict	Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	831	831	Sequence conflict	Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	831	831	Sequence conflict	Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	899	899	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	899	899	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	899	899	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	923	923	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	923	923	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	923	923	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	935	935	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	935	935	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	935	935	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	947	947	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	947	947	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	947	947	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	960	960	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	960	960	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFATC3	Q12968	699	1035	960	960	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPBL	Q6KC79	498	1040	1	2804	Chain	ID=PRO_0000218596;Note=Nipped-B-like protein
NIPBL	Q6KC79	1040	1101	1	2804	Chain	ID=PRO_0000218596;Note=Nipped-B-like protein
NIPBL	Q6KC79	1101	1167	1	2804	Chain	ID=PRO_0000218596;Note=Nipped-B-like protein
NIPBL	Q6KC79	1903	1936	1	2804	Chain	ID=PRO_0000218596;Note=Nipped-B-like protein
NIPBL	Q6KC79	2354	2421	1	2804	Chain	ID=PRO_0000218596;Note=Nipped-B-like protein
NIPBL	Q6KC79	2421	2470	1	2804	Chain	ID=PRO_0000218596;Note=Nipped-B-like protein
NIPBL	Q6KC79	498	1040	996	1009	Motif	Note=PxVxL motif;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20562864,ECO:0000269|PubMed:28167679;Dbxref=PMID:20562864,PMID:28167679
NIPBL	Q6KC79	498	1040	713	713	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
NIPBL	Q6KC79	498	1040	746	746	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
NIPBL	Q6KC79	498	1040	912	912	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NIPBL	Q6KC79	1040	1101	1082	1082	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6KCD5
NIPBL	Q6KC79	1040	1101	1089	1089	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
NIPBL	Q6KC79	1040	1101	1090	1090	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
NIPBL	Q6KC79	1040	1101	1096	1096	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:21406692
NIPBL	Q6KC79	1101	1167	1150	1150	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692
NIPBL	Q6KC79	1101	1167	1152	1152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
NIPBL	Q6KC79	1101	1167	1154	1154	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
NIPBL	Q6KC79	1101	1167	1159	1159	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6KCD5
NIPBL	Q6KC79	1101	1167	1160	1160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
NIPBL	Q6KC79	1101	1167	1102	2804	Alternative sequence	ID=VSP_011091;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NIPBL	Q6KC79	1903	1936	1102	2804	Alternative sequence	ID=VSP_011091;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NIPBL	Q6KC79	2354	2421	1102	2804	Alternative sequence	ID=VSP_011091;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NIPBL	Q6KC79	2421	2470	1102	2804	Alternative sequence	ID=VSP_011091;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NIPBL	Q6KC79	498	1040	674	674	Natural variant	ID=VAR_021596;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15318302;Dbxref=dbSNP:rs3822471,PMID:15318302
NIPBL	Q6KC79	498	1040	868	868	Natural variant	ID=VAR_073008;Note=In CDLS1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23254390;Dbxref=dbSNP:rs149629686,PMID:23254390
NIPBL	Q6KC79	2354	2421	2381	2381	Natural variant	ID=VAR_021606;Note=In CDLS1. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15318302;Dbxref=PMID:15318302
NIPBL	Q6KC79	2354	2421	2390	2390	Natural variant	ID=VAR_021607;Note=In CDLS1. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15318302;Dbxref=dbSNP:rs587784036,PMID:15318302
NIPBL	Q6KC79	2421	2470	2430	2430	Natural variant	ID=VAR_019521;Note=In CDLS1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15146185;Dbxref=dbSNP:rs121918265,PMID:15146185
NIPBL	Q6KC79	2421	2470	2433	2433	Natural variant	ID=VAR_073018;Note=In CDLS1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23254390;Dbxref=PMID:23254390
NIPBL	Q6KC79	2421	2470	2440	2440	Natural variant	ID=VAR_021608;Note=In CDLS1. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15318302;Dbxref=PMID:15318302
NIPBL	Q6KC79	498	1040	1003	1003	Mutagenesis	Note=Abolishes interaction with CBX3%3B when associated with A-1005. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20562864,ECO:0000269|PubMed:28167679;Dbxref=PMID:20562864,PMID:28167679
NIPBL	Q6KC79	498	1040	1003	1003	Mutagenesis	Note=Abolishes interaction with CBX5%3B when associated with E-1005. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20562864;Dbxref=PMID:20562864
NIPBL	Q6KC79	498	1040	1005	1005	Mutagenesis	Note=Abolishes interaction with CBX3%3B when associated with A-1003. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20562864;Dbxref=PMID:20562864
NIPBL	Q6KC79	498	1040	1005	1005	Mutagenesis	Note=Abolishes interaction with CBX5%3B when associated with E-1003. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20562864;Dbxref=PMID:20562864
NIPBL	Q6KC79	498	1040	548	548	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPBL	Q6KC79	498	1040	548	548	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPBL	Q6KC79	498	1040	574	574	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPBL	Q6KC79	498	1040	574	574	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPBL	Q6KC79	498	1040	648	648	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIPBL	Q6KC79	498	1040	648	648	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NIP7	Q9Y221	94	141	1	180	Chain	ID=PRO_0000218773;Note=60S ribosome subunit biogenesis protein NIP7 homolog
NIP7	Q9Y221	94	141	94	170	Domain	Note=PUA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00161
NIP7	Q9Y221	94	141	93	180	Region	Note=C-terminal domain
NIP7	Q9Y221	94	141	95	141	Alternative sequence	ID=VSP_012094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11042152;Dbxref=PMID:11042152
NIP7	Q9Y221	94	141	96	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIP7	Q9Y221	94	141	101	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIP7	Q9Y221	94	141	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIP7	Q9Y221	94	141	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIP7	Q9Y221	94	141	118	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIP7	Q9Y221	94	141	130	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIP7	Q9Y221	94	141	140	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQW
NIPAL4	Q0D2K0	154	173	1	466	Chain	ID=PRO_0000284447;Note=Magnesium transporter NIPA4
NIPAL4	Q0D2K0	154	173	139	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPAL4	Q0D2K0	154	173	165	185	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPAL4	Q0D2K0	154	173	156	174	Alternative sequence	ID=VSP_036122;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NMD3	Q96D46	15	59	1	503	Chain	ID=PRO_0000323561;Note=60S ribosomal export protein NMD3
NMD3	Q96D46	92	119	1	503	Chain	ID=PRO_0000323561;Note=60S ribosomal export protein NMD3
NMD3	Q96D46	119	162	1	503	Chain	ID=PRO_0000323561;Note=60S ribosomal export protein NMD3
NMD3	Q96D46	15	59	1	503	Chain	ID=PRO_0000323561;Note=60S ribosomal export protein NMD3
NMD3	Q96D46	92	119	1	503	Chain	ID=PRO_0000323561;Note=60S ribosomal export protein NMD3
NMD3	Q96D46	119	162	1	503	Chain	ID=PRO_0000323561;Note=60S ribosomal export protein NMD3
NMT2	O60551	446	492	1	498	Chain	ID=PRO_0000064226;Note=Glycylpeptide N-tetradecanoyltransferase 2
NMT2	O60551	390	446	1	498	Chain	ID=PRO_0000064226;Note=Glycylpeptide N-tetradecanoyltransferase 2
NMT2	O60551	333	390	1	498	Chain	ID=PRO_0000064226;Note=Glycylpeptide N-tetradecanoyltransferase 2
NMT2	O60551	240	296	1	498	Chain	ID=PRO_0000064226;Note=Glycylpeptide N-tetradecanoyltransferase 2
NMT2	O60551	240	296	250	252	Region	Note=Myristoyl-CoA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25255805;Dbxref=PMID:25255805
NMT2	O60551	240	296	258	262	Region	Note=Myristoyl-CoA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25255805;Dbxref=PMID:25255805
NMT2	O60551	240	296	240	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	240	296	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	240	296	262	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	240	296	275	277	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	240	296	281	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	240	296	293	303	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	340	342	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	345	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	348	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	359	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	362	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	370	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	381	383	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	384	390	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	333	390	384	390	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	392	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	396	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	416	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	420	423	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	427	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	433	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	446	492	446	448	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	390	446	446	448	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	446	492	450	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	446	492	460	462	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	446	492	463	468	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	446	492	470	482	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
NMT2	O60551	446	492	490	492	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C2X
PMP22	Q01453	59	106	1	160	Chain	ID=PRO_0000164650;Note=Peripheral myelin protein 22
PMP22	Q01453	59	106	1	160	Chain	ID=PRO_0000164650;Note=Peripheral myelin protein 22
PMP22	Q01453	59	106	32	64	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMP22	Q01453	59	106	32	64	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMP22	Q01453	59	106	65	91	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
PMP22	Q01453	59	106	65	91	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
PMP22	Q01453	59	106	92	95	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMP22	Q01453	59	106	92	95	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMP22	Q01453	59	106	96	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
PMP22	Q01453	59	106	96	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
PMP22	Q01453	59	106	65	65	Natural variant	ID=VAR_029964;Note=In CMT1A. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12497641;Dbxref=PMID:12497641
PMP22	Q01453	59	106	65	65	Natural variant	ID=VAR_029964;Note=In CMT1A. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12497641;Dbxref=PMID:12497641
PMP22	Q01453	59	106	67	67	Natural variant	ID=VAR_009661;Note=In CMT1E. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10330345;Dbxref=dbSNP:rs104894623,PMID:10330345
PMP22	Q01453	59	106	67	67	Natural variant	ID=VAR_009661;Note=In CMT1E. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10330345;Dbxref=dbSNP:rs104894623,PMID:10330345
PMP22	Q01453	59	106	67	67	Natural variant	ID=VAR_029965;Note=In HNPP. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12796555;Dbxref=dbSNP:rs104894623,PMID:12796555
PMP22	Q01453	59	106	67	67	Natural variant	ID=VAR_029965;Note=In HNPP. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12796555;Dbxref=dbSNP:rs104894623,PMID:12796555
PMP22	Q01453	59	106	69	69	Natural variant	ID=VAR_006362;Note=In DSS. M->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8252046,ECO:0000269|PubMed:8275092;Dbxref=dbSNP:rs104894620,PMID:8252046,PMID:8275092
PMP22	Q01453	59	106	69	69	Natural variant	ID=VAR_006362;Note=In DSS. M->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8252046,ECO:0000269|PubMed:8275092;Dbxref=dbSNP:rs104894620,PMID:8252046,PMID:8275092
PMP22	Q01453	59	106	71	71	Natural variant	ID=VAR_029966;Note=In DSS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11835375;Dbxref=PMID:11835375
PMP22	Q01453	59	106	71	71	Natural variant	ID=VAR_029966;Note=In DSS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11835375;Dbxref=PMID:11835375
PMP22	Q01453	59	106	72	72	Natural variant	ID=VAR_006363;Note=In DSS and CMT1A. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11140841,ECO:0000269|PubMed:11438991,ECO:0000269|PubMed:12402337,ECO:0000269|PubMed:7675244,ECO:0000269|PubMed:8252046,ECO:0000269|PubMed:8275092,ECO:0000269|PubMed:9004143,ECO:0000269|PubMed:9585367;Dbxref=dbSNP:rs104894621,PMID:11140841,PMID:11438991,PMID:12402337,PMID:7675244,PMID:8252046,PMID:8275092,PMID:9004143,PMID:9585367
PMP22	Q01453	59	106	72	72	Natural variant	ID=VAR_006363;Note=In DSS and CMT1A. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11140841,ECO:0000269|PubMed:11438991,ECO:0000269|PubMed:12402337,ECO:0000269|PubMed:7675244,ECO:0000269|PubMed:8252046,ECO:0000269|PubMed:8275092,ECO:0000269|PubMed:9004143,ECO:0000269|PubMed:9585367;Dbxref=dbSNP:rs104894621,PMID:11140841,PMID:11438991,PMID:12402337,PMID:7675244,PMID:8252046,PMID:8275092,PMID:9004143,PMID:9585367
PMP22	Q01453	59	106	72	72	Natural variant	ID=VAR_006364;Note=In DSS. S->P
PMP22	Q01453	59	106	72	72	Natural variant	ID=VAR_006364;Note=In DSS. S->P
PMP22	Q01453	59	106	72	72	Natural variant	ID=VAR_006365;Note=In DSS. S->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9055797;Dbxref=PMID:9055797
PMP22	Q01453	59	106	72	72	Natural variant	ID=VAR_006365;Note=In DSS. S->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9055797;Dbxref=PMID:9055797
PMP22	Q01453	59	106	76	76	Natural variant	ID=VAR_006366;Note=In DSS. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9055797;Dbxref=PMID:9055797
PMP22	Q01453	59	106	76	76	Natural variant	ID=VAR_006366;Note=In DSS. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9055797;Dbxref=PMID:9055797
PMP22	Q01453	59	106	79	79	Natural variant	ID=VAR_006367;Note=In CMT1A. S->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8252046,ECO:0000269|PubMed:8510709;Dbxref=dbSNP:rs104894618,PMID:8252046,PMID:8510709
PMP22	Q01453	59	106	79	79	Natural variant	ID=VAR_006367;Note=In CMT1A. S->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8252046,ECO:0000269|PubMed:8510709;Dbxref=dbSNP:rs104894618,PMID:8252046,PMID:8510709
PMP22	Q01453	59	106	79	79	Natural variant	ID=VAR_006368;Note=In DSS. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452053;Dbxref=PMID:9452053
PMP22	Q01453	59	106	79	79	Natural variant	ID=VAR_006368;Note=In DSS. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452053;Dbxref=PMID:9452053
PMP22	Q01453	59	106	80	80	Natural variant	ID=VAR_006369;Note=In DSS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9055797;Dbxref=PMID:9055797
PMP22	Q01453	59	106	80	80	Natural variant	ID=VAR_006369;Note=In DSS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9055797;Dbxref=PMID:9055797
PMP22	Q01453	59	106	80	80	Natural variant	ID=VAR_029967;Note=In DSS. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12090401;Dbxref=PMID:12090401
PMP22	Q01453	59	106	80	80	Natural variant	ID=VAR_029967;Note=In DSS. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12090401;Dbxref=PMID:12090401
PMP22	Q01453	59	106	84	84	Natural variant	ID=VAR_006370;Note=In DSS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9633821;Dbxref=PMID:9633821
PMP22	Q01453	59	106	84	84	Natural variant	ID=VAR_006370;Note=In DSS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9633821;Dbxref=PMID:9633821
PMP22	Q01453	59	106	93	93	Natural variant	ID=VAR_009662;Note=In CMT1A. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8777804;Dbxref=dbSNP:rs778693173,PMID:8777804
PMP22	Q01453	59	106	93	93	Natural variant	ID=VAR_009662;Note=In CMT1A. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8777804;Dbxref=dbSNP:rs778693173,PMID:8777804
PMP22	Q01453	59	106	100	100	Natural variant	ID=VAR_006371;Note=In DSS. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9585367;Dbxref=PMID:9585367
PMP22	Q01453	59	106	100	100	Natural variant	ID=VAR_006371;Note=In DSS. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9585367;Dbxref=PMID:9585367
PMP22	Q01453	59	106	100	100	Natural variant	ID=VAR_006372;Note=In DSS. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9187667;Dbxref=PMID:9187667
PMP22	Q01453	59	106	100	100	Natural variant	ID=VAR_006372;Note=In DSS. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9187667;Dbxref=PMID:9187667
PMP22	Q01453	59	106	105	105	Natural variant	ID=VAR_006373;Note=In CMT1A and DSS. L->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12090401,ECO:0000269|PubMed:8615087;Dbxref=PMID:12090401,PMID:8615087
PMP22	Q01453	59	106	105	105	Natural variant	ID=VAR_006373;Note=In CMT1A and DSS. L->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12090401,ECO:0000269|PubMed:8615087;Dbxref=PMID:12090401,PMID:8615087
NOD1	Q9Y239	902	929	1	953	Chain	ID=PRO_0000144077;Note=Nucleotide-binding oligomerization domain-containing protein 1
NOD1	Q9Y239	874	901	1	953	Chain	ID=PRO_0000144077;Note=Nucleotide-binding oligomerization domain-containing protein 1
NOD1	Q9Y239	818	845	1	953	Chain	ID=PRO_0000144077;Note=Nucleotide-binding oligomerization domain-containing protein 1
NOD1	Q9Y239	818	845	839	862	Repeat	Note=LRR 6
NOD1	Q9Y239	874	901	867	891	Repeat	Note=LRR 7
NOD1	Q9Y239	902	929	895	918	Repeat	Note=LRR 8
NOD1	Q9Y239	874	901	895	918	Repeat	Note=LRR 8
NOD1	Q9Y239	902	929	923	946	Repeat	Note=LRR 9
NOD1	Q9Y239	902	929	250	953	Alternative sequence	ID=VSP_055826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOD1	Q9Y239	874	901	250	953	Alternative sequence	ID=VSP_055826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOD1	Q9Y239	818	845	250	953	Alternative sequence	ID=VSP_055826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NOD1	Q9Y239	874	901	877	877	Mutagenesis	Note=Does not associate with cell membrane. Q->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17970764;Dbxref=PMID:17970764
NDUFAF5	Q5TEU4	109	125	37	345	Chain	ID=PRO_0000307213;Note=Arginine-hydroxylase NDUFAF5%2C mitochondrial
NDUFAF5	Q5TEU4	173	239	37	345	Chain	ID=PRO_0000307213;Note=Arginine-hydroxylase NDUFAF5%2C mitochondrial
NDUFAF5	Q5TEU4	259	287	37	345	Chain	ID=PRO_0000307213;Note=Arginine-hydroxylase NDUFAF5%2C mitochondrial
NDUFAF5	Q5TEU4	109	125	110	160	Alternative sequence	ID=VSP_028637;Note=In isoform 2. ETIGKFFQADIAENALKNSSETEIPTVSVLADEEFLPFKENTFDLVVSSLS->LQLFHCRKLLESFSKLTLQKMLC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NDUFAF5	Q5TEU4	173	239	229	229	Natural variant	ID=VAR_054119;Note=In MT-C1D. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18940309;Dbxref=dbSNP:rs118203929,PMID:18940309
NDUFV2	P19404	18	40	1	32	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25944712;Dbxref=PMID:25944712
NDUFV2	P19404	18	40	33	249	Chain	ID=PRO_0000020003;Note=NADH dehydrogenase [ubiquinone] flavoprotein 2%2C mitochondrial
NDUFV2	P19404	40	61	33	249	Chain	ID=PRO_0000020003;Note=NADH dehydrogenase [ubiquinone] flavoprotein 2%2C mitochondrial
NDUFV2	P19404	40	61	61	61	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D6J6
NDUFV2	P19404	18	40	29	29	Natural variant	ID=VAR_016167;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2500970;Dbxref=dbSNP:rs906807,PMID:2500970
NDUFV2	P19404	40	61	48	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFV2	P19404	40	61	57	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NELL1	Q92832	112	168	22	810	Chain	ID=PRO_0000007664;Note=Protein kinase C-binding protein NELL1
NELL1	Q92832	433	475	22	810	Chain	ID=PRO_0000007664;Note=Protein kinase C-binding protein NELL1
NELL1	Q92832	475	516	22	810	Chain	ID=PRO_0000007664;Note=Protein kinase C-binding protein NELL1
NELL1	Q92832	516	548	22	810	Chain	ID=PRO_0000007664;Note=Protein kinase C-binding protein NELL1
NELL1	Q92832	548	595	22	810	Chain	ID=PRO_0000007664;Note=Protein kinase C-binding protein NELL1
NELL1	Q92832	112	168	64	227	Domain	Note=Laminin G-like
NELL1	Q92832	433	475	434	475	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	475	516	434	475	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	475	516	476	516	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	516	548	476	516	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	516	548	517	547	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	548	595	549	587	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	475	516	511	511	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NELL1	Q92832	548	595	562	562	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NELL1	Q92832	433	475	438	451	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	433	475	445	460	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	433	475	462	474	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	475	516	480	493	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	475	516	487	502	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	475	516	504	515	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	516	548	519	529	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	516	548	523	535	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	516	548	537	546	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	548	595	553	566	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	548	595	560	575	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	548	595	577	594	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NELL1	Q92832	548	595	549	595	Alternative sequence	ID=VSP_039954;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NELL1	Q92832	548	595	553	553	Natural variant	ID=VAR_035834;Note=In a colorectal cancer sample%3B somatic mutation. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NELL1	Q92832	548	595	573	573	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
NTN5	Q8WTR8	341	368	17	489	Chain	ID=PRO_0000320575;Note=Netrin-5
NTN5	Q8WTR8	341	368	345	475	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
NTN5	Q8WTR8	341	368	345	418	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN5	Q8WTR8	341	368	349	420	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN5	Q8WTR8	341	368	364	475	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NTN5	Q8WTR8	341	368	342	350	Alternative sequence	ID=VSP_031667;Note=In isoform 2. DPQCQNYCN->GKTVWHGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NTN5	Q8WTR8	341	368	351	489	Alternative sequence	ID=VSP_031668;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NLN	Q9BYT8	150	186	38	704	Chain	ID=PRO_0000028575;Note=Neurolysin%2C mitochondrial
NLN	Q9BYT8	150	186	140	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LUZ
NLN	Q9BYT8	150	186	155	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LUZ
NLN	Q9BYT8	150	186	160	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LUZ
NLN	Q9BYT8	150	186	176	179	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LUZ
NLN	Q9BYT8	150	186	182	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LUZ
NFE2L1	Q14494	241	271	1	772	Chain	ID=PRO_0000076447;Note=Endoplasmic reticulum membrane sensor NFE2L1
NFE2L1	Q14494	241	271	104	772	Chain	ID=PRO_0000443103;Note=Transcription factor NRF1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24448410;Dbxref=PMID:24448410
NFE2L1	Q14494	241	271	125	288	Compositional bias	Note=Asp/Glu-rich (acidic)
NFE2L1	Q14494	241	271	242	271	Alternative sequence	ID=VSP_000579;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8248256;Dbxref=PMID:15489334,PMID:8248256
NFAM1	Q8NET5	221	251	43	270	Chain	ID=PRO_0000015046;Note=NFAT activation molecule 1
NFAM1	Q8NET5	221	251	185	270	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NFAM1	Q8NET5	221	251	209	237	Domain	Note=ITAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00379
NFAM1	Q8NET5	221	251	231	231	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305
NFAM1	Q8NET5	221	251	231	231	Mutagenesis	Note=Abolishes the ITAM-mediated-activating activity. Y->A%2CF;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12615919,ECO:0000269|PubMed:15143214;Dbxref=PMID:12615919,PMID:15143214
NNT	Q13423	686	764	44	1086	Chain	ID=PRO_0000001055;Note=NAD(P) transhydrogenase%2C mitochondrial
NNT	Q13423	686	764	44	1086	Chain	ID=PRO_0000001055;Note=NAD(P) transhydrogenase%2C mitochondrial
NNT	Q13423	686	764	672	691	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NNT	Q13423	686	764	672	691	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NNT	Q13423	686	764	702	722	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NNT	Q13423	686	764	702	722	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NNT	Q13423	686	764	723	739	Topological domain	Note=Cytoplasmic
NNT	Q13423	686	764	723	739	Topological domain	Note=Cytoplasmic
NNT	Q13423	686	764	740	760	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NNT	Q13423	686	764	740	760	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NNT	Q13423	686	764	706	706	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NNT	Q13423	686	764	706	706	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NNT	Q13423	686	764	731	731	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
NNT	Q13423	686	764	731	731	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
NOC4L	Q9BVI4	246	263	1	516	Chain	ID=PRO_0000173484;Note=Nucleolar complex protein 4 homolog
NOC4L	Q9BVI4	439	477	1	516	Chain	ID=PRO_0000173484;Note=Nucleolar complex protein 4 homolog
EXOC4	Q96A65	624	675	2	974	Chain	ID=PRO_0000118934;Note=Exocyst complex component 4
EXOC4	Q96A65	624	675	474	974	Alternative sequence	ID=VSP_047159;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FARP2	O94887	344	366	1	1054	Chain	ID=PRO_0000232755;Note=FERM%2C ARHGEF and pleckstrin domain-containing protein 2
FARP2	O94887	929	965	1	1054	Chain	ID=PRO_0000232755;Note=FERM%2C ARHGEF and pleckstrin domain-containing protein 2
FARP2	O94887	929	965	929	1026	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FARP2	O94887	929	965	639	1054	Alternative sequence	ID=VSP_054841;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FARP2	O94887	929	965	648	1054	Alternative sequence	ID=VSP_017978;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FARP2	O94887	344	366	366	366	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	4333	4379	22	4588	Chain	ID=PRO_0000004017;Note=Protocadherin Fat 1
FAT1	Q14517	1603	2959	22	4588	Chain	ID=PRO_0000004017;Note=Protocadherin Fat 1
FAT1	Q14517	1214	1324	22	4588	Chain	ID=PRO_0000004017;Note=Protocadherin Fat 1
FAT1	Q14517	1088	1193	22	4588	Chain	ID=PRO_0000004017;Note=Protocadherin Fat 1
FAT1	Q14517	1603	2959	22	4181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1214	1324	22	4181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1088	1193	22	4181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	4333	4379	4203	4588	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1088	1193	1035	1139	Domain	Note=Cadherin 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1214	1324	1140	1245	Domain	Note=Cadherin 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1088	1193	1140	1245	Domain	Note=Cadherin 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1214	1324	1246	1357	Domain	Note=Cadherin 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	1563	1667	Domain	Note=Cadherin 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	1668	1765	Domain	Note=Cadherin 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	1766	1879	Domain	Note=Cadherin 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	1880	1979	Domain	Note=Cadherin 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	1980	2081	Domain	Note=Cadherin 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2082	2182	Domain	Note=Cadherin 19;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2183	2283	Domain	Note=Cadherin 20;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2284	2390	Domain	Note=Cadherin 21;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2391	2492	Domain	Note=Cadherin 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2493	2596	Domain	Note=Cadherin 23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2597	2703	Domain	Note=Cadherin 24;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2704	2809	Domain	Note=Cadherin 25;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2810	2918	Domain	Note=Cadherin 26;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	1603	2959	2919	3023	Domain	Note=Cadherin 27;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT1	Q14517	4333	4379	4378	4382	Motif	Note=PTB-like motif;Ontology_term=ECO:0000250;evidence=ECO:0000250
FAT1	Q14517	1603	2959	1748	1748	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1603	2959	1864	1864	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1603	2959	1902	1902	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1603	2959	1940	1940	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1603	2959	1991	1991	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1603	2959	2325	2325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1603	2959	2464	2464	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT1	Q14517	1088	1193	1147	1147	Natural variant	ID=VAR_080733;Note=Found in a patient with spinocerebellar ataxia%3B unknown pathological significance. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29053796;Dbxref=PMID:29053796
FAT1	Q14517	1603	2959	1605	1605	Natural variant	ID=VAR_055593;Note=N->D;Dbxref=dbSNP:rs6836935
FAT1	Q14517	1603	2959	1930	1930	Natural variant	ID=VAR_080734;Note=Found in a patient with spinocerebellar ataxia%3B unknown pathological significance. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29053796;Dbxref=PMID:29053796
FAT1	Q14517	1214	1324	1273	1273	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	1603	2959	1604	1604	Sequence conflict	Note=G->GNIG;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	1603	2959	2006	2006	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	1603	2959	2054	2054	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	1603	2959	2385	2385	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	1603	2959	2618	2619	Sequence conflict	Note=VL->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT1	Q14517	1603	2959	2718	2718	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXW11	Q9UKB1	217	263	1	542	Chain	ID=PRO_0000050981;Note=F-box/WD repeat-containing protein 11
FBXW11	Q9UKB1	15	49	1	542	Chain	ID=PRO_0000050981;Note=F-box/WD repeat-containing protein 11
FBXW11	Q9UKB1	217	263	238	275	Repeat	Note=WD 1
FBXW11	Q9UKB1	15	49	16	49	Alternative sequence	ID=VSP_006765;Note=In isoform A. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FBXW11	Q9UKB1	15	49	16	48	Alternative sequence	ID=VSP_006766;Note=In isoform B. CSVPRSLWLGCANLVESMCALSCLQSMPSVRCL->NTSVMEDQNEDESPKKNTLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBXO31	Q5XUX0	219	244	1	539	Chain	ID=PRO_0000119921;Note=F-box only protein 31
FBXO31	Q5XUX0	219	244	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZT
FBXO31	Q5XUX0	219	244	222	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZT
FBXO31	Q5XUX0	219	244	233	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZT
FBXO31	Q5XUX0	219	244	242	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZT
FBXO32	Q969P5	217	278	1	355	Chain	ID=PRO_0000119922;Note=F-box only protein 32
FBXO32	Q969P5	217	278	223	271	Domain	Note=F-box
FBXO32	Q969P5	217	278	243	243	Natural variant	ID=VAR_076453;Note=Probable disease-associated mutation found in patients with familial dilated cardiomyopathy%3B impairs the formation of SCF complex%3B reduced ubiquitination of cellular proteins. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26753747,ECO:0000269|PubMed:26768247;Dbxref=dbSNP:rs771939133,PMID:26753747,PMID:26768247
FERMT1	Q9BQL6	457	531	1	677	Chain	ID=PRO_0000219452;Note=Fermitin family homolog 1
FERMT1	Q9BQL6	457	531	96	653	Domain	Note=FERM
FERMT1	Q9BQL6	457	531	377	473	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FERMT1	Q9BQL6	457	531	458	495	Alternative sequence	ID=VSP_009224;Note=In isoform 4. ENQYAQWMAACMLASKGKTMADSSYQPEVLNILSFLRM->VSKTPKILSHFTSTKPKSKTQKCFHKFRALLCHSAIAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FERMT1	Q9BQL6	457	531	496	677	Alternative sequence	ID=VSP_009225;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FERMT1	Q9BQL6	457	531	526	526	Natural variant	ID=VAR_014398;Note=R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12697302,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2232074,PMID:12697302,PMID:14702039
HAUS1	Q96CS2	114	158	1	278	Chain	ID=PRO_0000089395;Note=HAUS augmin-like complex subunit 1
HAUS1	Q96CS2	200	222	1	278	Chain	ID=PRO_0000089395;Note=HAUS augmin-like complex subunit 1
HAUS1	Q96CS2	222	246	1	278	Chain	ID=PRO_0000089395;Note=HAUS augmin-like complex subunit 1
HAUS1	Q96CS2	246	262	1	278	Chain	ID=PRO_0000089395;Note=HAUS augmin-like complex subunit 1
HAUS1	Q96CS2	114	158	124	177	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HAUS1	Q96CS2	246	262	249	277	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HAUS4	Q9H6D7	110	155	1	363	Chain	ID=PRO_0000089901;Note=HAUS augmin-like complex subunit 4
HAUS4	Q9H6D7	110	155	1	363	Chain	ID=PRO_0000089901;Note=HAUS augmin-like complex subunit 4
HAUS4	Q9H6D7	110	155	1	124	Alternative sequence	ID=VSP_007851;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HAUS4	Q9H6D7	110	155	1	124	Alternative sequence	ID=VSP_007851;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HAUS4	Q9H6D7	110	155	111	236	Alternative sequence	ID=VSP_007853;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HAUS4	Q9H6D7	110	155	111	236	Alternative sequence	ID=VSP_007853;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HAUS4	Q9H6D7	110	155	111	155	Alternative sequence	ID=VSP_007852;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HAUS4	Q9H6D7	110	155	111	155	Alternative sequence	ID=VSP_007852;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HAUS4	Q9H6D7	110	155	154	154	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HAUS4	Q9H6D7	110	155	154	154	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGD6	Q6ZV73	1326	1369	1	1430	Chain	ID=PRO_0000080952;Note=FYVE%2C RhoGEF and PH domain-containing protein 6
FGD6	Q6ZV73	1111	1139	1	1430	Chain	ID=PRO_0000080952;Note=FYVE%2C RhoGEF and PH domain-containing protein 6
FGD6	Q6ZV73	1088	1111	1	1430	Chain	ID=PRO_0000080952;Note=FYVE%2C RhoGEF and PH domain-containing protein 6
FGD6	Q6ZV73	1111	1139	1089	1183	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD6	Q6ZV73	1088	1111	1089	1183	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD6	Q6ZV73	1326	1369	1333	1429	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD6	Q6ZV73	1111	1139	1115	1115	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGD3	Q5JSP0	151	181	1	725	Chain	ID=PRO_0000080944;Note=FYVE%2C RhoGEF and PH domain-containing protein 3
FGD3	Q5JSP0	345	394	1	725	Chain	ID=PRO_0000080944;Note=FYVE%2C RhoGEF and PH domain-containing protein 3
FGD3	Q5JSP0	151	181	1	725	Chain	ID=PRO_0000080944;Note=FYVE%2C RhoGEF and PH domain-containing protein 3
FGD3	Q5JSP0	345	394	1	725	Chain	ID=PRO_0000080944;Note=FYVE%2C RhoGEF and PH domain-containing protein 3
FGD3	Q5JSP0	151	181	157	341	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
FGD3	Q5JSP0	151	181	157	341	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
FGD3	Q5JSP0	345	394	370	469	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD3	Q5JSP0	345	394	370	469	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD4	Q96M96	545	587	1	766	Chain	ID=PRO_0000080947;Note=FYVE%2C RhoGEF and PH domain-containing protein 4
FGD4	Q96M96	587	634	1	766	Chain	ID=PRO_0000080947;Note=FYVE%2C RhoGEF and PH domain-containing protein 4
FGD4	Q96M96	545	587	559	619	Zinc finger	Note=FYVE-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091
FGD4	Q96M96	587	634	559	619	Zinc finger	Note=FYVE-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091
FGD4	Q96M96	545	587	208	766	Alternative sequence	ID=VSP_013081;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FGD4	Q96M96	587	634	208	766	Alternative sequence	ID=VSP_013081;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FGD4	Q96M96	545	587	515	766	Alternative sequence	ID=VSP_013082;Note=In isoform 2. ALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC->RRGFAMLPRLISNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
FGD4	Q96M96	587	634	515	766	Alternative sequence	ID=VSP_013082;Note=In isoform 2. ALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC->RRGFAMLPRLISNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
FGB	P02675	163	239	45	491	Chain	ID=PRO_0000009071;Note=Fibrinogen beta chain
FGB	P02675	239	277	45	491	Chain	ID=PRO_0000009071;Note=Fibrinogen beta chain
FGB	P02675	277	319	45	491	Chain	ID=PRO_0000009071;Note=Fibrinogen beta chain
FGB	P02675	163	239	232	488	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
FGB	P02675	239	277	232	488	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
FGB	P02675	277	319	232	488	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
FGB	P02675	163	239	157	222	Coiled coil	Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10074346,ECO:0000305|PubMed:19296670,ECO:0000305|PubMed:9628725;Dbxref=PMID:10074346,PMID:19296670,PMID:9628725
FGB	P02675	163	239	163	164	Site	Note=Cleavage%3B by plasmin%3B to break down fibrin clots
FGB	P02675	163	239	223	223	Disulfide bond	Note=Interchain (with C-184 in alpha chain);Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1FZC,ECO:0000269|PubMed:10074346,ECO:0000269|PubMed:19296670,ECO:0000269|PubMed:9333233,ECO:0000269|PubMed:9628725;Dbxref=PMID:10074346,PMID:19296670,PMID:9333233,PMID:9628725
FGB	P02675	163	239	227	227	Disulfide bond	Note=Interchain (with C-161 in gamma chain)
FGB	P02675	163	239	231	316	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1FZC,ECO:0000269|PubMed:10074346,ECO:0000269|PubMed:19296670,ECO:0000269|PubMed:9333233,ECO:0000269|PubMed:9628725;Dbxref=PMID:10074346,PMID:19296670,PMID:9333233,PMID:9628725
FGB	P02675	239	277	231	316	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1FZC,ECO:0000269|PubMed:10074346,ECO:0000269|PubMed:19296670,ECO:0000269|PubMed:9333233,ECO:0000269|PubMed:9628725;Dbxref=PMID:10074346,PMID:19296670,PMID:9333233,PMID:9628725
FGB	P02675	277	319	231	316	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1FZC,ECO:0000269|PubMed:10074346,ECO:0000269|PubMed:19296670,ECO:0000269|PubMed:9333233,ECO:0000269|PubMed:9628725;Dbxref=PMID:10074346,PMID:19296670,PMID:9333233,PMID:9628725
FGB	P02675	239	277	241	270	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1FZC,ECO:0000269|PubMed:10074346,ECO:0000269|PubMed:19296670,ECO:0000269|PubMed:9333233,ECO:0000269|PubMed:9628725;Dbxref=PMID:10074346,PMID:19296670,PMID:9333233,PMID:9628725
FGB	P02675	163	239	170	170	Natural variant	ID=VAR_013092;Note=N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs2227409
FGB	P02675	163	239	196	196	Natural variant	ID=VAR_016908;Note=In CAFBN%3B fibrinogen Longmont. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11468164;Dbxref=dbSNP:rs121909623,PMID:11468164
FGB	P02675	163	239	202	202	Natural variant	ID=VAR_072620;Note=In CAFBN. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15070683;Dbxref=dbSNP:rs121909624,PMID:15070683
FGB	P02675	239	277	265	265	Natural variant	ID=VAR_013093;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|Ref.4;Dbxref=dbSNP:rs6054,PMID:10391209
FGB	P02675	163	239	192	192	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGB	P02675	239	277	245	245	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGB	P02675	163	239	147	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GHG
FGB	P02675	163	239	172	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GHG
FGB	P02675	163	239	182	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	163	239	190	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	163	239	224	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HOD
FGB	P02675	163	239	233	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	163	239	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	239	277	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	239	277	241	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	239	277	253	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	239	277	261	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OYH
FGB	P02675	239	277	266	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	239	277	274	276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	277	319	279	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	277	319	296	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	277	319	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZF
FGB	P02675	277	319	306	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZC
FGB	P02675	277	319	311	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H43
FLI1	Q01543	128	196	1	452	Chain	ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor
FLI1	Q01543	218	240	1	452	Chain	ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor
FLI1	Q01543	240	260	1	452	Chain	ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor
FLI1	Q01543	128	196	112	198	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
FLI1	Q01543	128	196	1	197	Alternative sequence	ID=VSP_046943;Note=In isoform 4. MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRES->MDPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FLI1	Q01543	128	196	130	130	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FLI1	Q01543	128	196	130	130	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FLI1	Q01543	128	196	133	133	Sequence conflict	Note=W->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FLI1	Q01543	128	196	133	133	Sequence conflict	Note=W->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FLI1	Q01543	128	196	130	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X66
FLI1	Q01543	128	196	137	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X66
FLI1	Q01543	128	196	156	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X66
FLI1	Q01543	128	196	164	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X66
FLI1	Q01543	128	196	172	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X66
FLI1	Q01543	128	196	181	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X66
HCST	Q9UBK5	36	80	19	93	Chain	ID=PRO_0000330287;Note=Hematopoietic cell signal transducer
HCST	Q9UBK5	36	80	19	48	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HCST	Q9UBK5	36	80	49	69	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HCST	Q9UBK5	36	80	70	93	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HCST	Q9UBK5	36	80	57	57	Mutagenesis	Note=Abolishes stable interaction with KLRK1. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10426994;Dbxref=PMID:10426994
MTFMT	Q96DP5	140	180	141	144	Alternative sequence	ID=VSP_057059;Note=In isoform 2. GILN->SFQF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTFMT	Q96DP5	140	180	145	389	Alternative sequence	ID=VSP_057060;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM131C	Q96AQ9	89	150	1	280	Chain	ID=PRO_0000280401;Note=Protein FAM131C
FAM131C	Q96AQ9	89	150	107	107	Natural variant	ID=VAR_031131;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs71510977,PMID:15489334
FAM131C	Q96AQ9	89	150	123	123	Natural variant	ID=VAR_031132;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11576236,PMID:14702039,PMID:15489334
FAM133B	Q5BKY9	203	219	1	247	Chain	ID=PRO_0000287616;Note=Protein FAM133B
FAM133B	Q5BKY9	172	203	1	247	Chain	ID=PRO_0000287616;Note=Protein FAM133B
FAM133B	Q5BKY9	103	124	1	247	Chain	ID=PRO_0000287616;Note=Protein FAM133B
FAM133B	Q5BKY9	203	219	45	238	Compositional bias	Note=Lys-rich
FAM133B	Q5BKY9	172	203	45	238	Compositional bias	Note=Lys-rich
FAM133B	Q5BKY9	103	124	45	238	Compositional bias	Note=Lys-rich
FAM133B	Q5BKY9	103	124	82	157	Compositional bias	Note=Ser-rich
FAM133B	Q5BKY9	172	203	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
FAM133B	Q5BKY9	172	203	192	192	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
FAM133B	Q5BKY9	172	203	194	194	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
FAM133B	Q5BKY9	172	203	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
FAM153B	P0C7A2	10	58	1	387	Chain	ID=PRO_0000329316;Note=Protein FAM153B
FAM161A	Q3B820	141	527	1	660	Chain	ID=PRO_0000329052;Note=Protein FAM161A
FAM161A	Q3B820	141	527	296	320	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM161A	Q3B820	141	527	522	552	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM161A	Q3B820	141	527	468	468	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FAM161A	Q3B820	141	527	484	484	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FAM161A	Q3B820	141	527	527	527	Alternative sequence	ID=VSP_039126;Note=In isoform 3. V->VRRSLEEKKMLEEERNRILTKQKQRMKELQKLLTTRAKAYDSHQSLAQISKSRVKCL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FAM161A	Q3B820	141	527	236	236	Natural variant	ID=VAR_042630;Note=I->V;Dbxref=dbSNP:rs17513722
FAM161A	Q3B820	141	527	273	273	Natural variant	ID=VAR_042631;Note=E->K;Dbxref=dbSNP:rs6733774
FAM161A	Q3B820	141	527	145	145	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM161A	Q3B820	141	527	167	167	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXTL3	O43909	807	850	1	919	Chain	ID=PRO_0000149657;Note=Exostosin-like 3
EXTL3	O43909	807	850	52	919	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXTL3	O43909	807	850	829	833	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXTL3	O43909	807	850	833	833	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXTL3	O43909	807	850	831	879	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXOSC10	Q01780	694	719	1	885	Chain	ID=PRO_0000087133;Note=Exosome component 10
EXOSC10	Q01780	529	545	1	885	Chain	ID=PRO_0000087133;Note=Exosome component 10
EXOSC10	Q01780	529	545	503	583	Domain	Note=HRDC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00328
EXOSC10	Q01780	694	719	710	710	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EXOSC10	Q01780	694	719	695	719	Alternative sequence	ID=VSP_004362;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1644924;Dbxref=PMID:1644924
EXOSC10	Q01780	529	545	528	531	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SAF
EXOSC10	Q01780	529	545	534	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SAF
FAM173A	Q9BQD7	54	89	1	235	Chain	ID=PRO_0000263721;Note=Protein N-lysine methyltransferase FAM173A
FAM173A	Q9BQD7	136	153	1	235	Chain	ID=PRO_0000263721;Note=Protein N-lysine methyltransferase FAM173A
FAM173A	Q9BQD7	136	153	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM91A1	Q658Y4	677	712	1	838	Chain	ID=PRO_0000282552;Note=Protein FAM91A1
FAM91A1	Q658Y4	677	712	704	704	Natural variant	ID=VAR_057768;Note=I->V;Dbxref=dbSNP:rs6470187
F8	P00451	2091	2143	20	2351	Chain	ID=PRO_0000002967;Note=Coagulation factor VIII
F8	P00451	1999	2038	20	2351	Chain	ID=PRO_0000002967;Note=Coagulation factor VIII
F8	P00451	634	704	20	2351	Chain	ID=PRO_0000002967;Note=Coagulation factor VIII
F8	P00451	200	223	20	2351	Chain	ID=PRO_0000002967;Note=Coagulation factor VIII
F8	P00451	634	704	20	1332	Chain	ID=PRO_0000002968;Note=Factor VIIIa heavy chain%2C 200 kDa isoform
F8	P00451	200	223	20	1332	Chain	ID=PRO_0000002968;Note=Factor VIIIa heavy chain%2C 200 kDa isoform
F8	P00451	634	704	20	759	Chain	ID=PRO_0000002969;Note=Factor VIIIa heavy chain%2C 92 kDa isoform
F8	P00451	200	223	20	759	Chain	ID=PRO_0000002969;Note=Factor VIIIa heavy chain%2C 92 kDa isoform
F8	P00451	2091	2143	1668	2351	Chain	ID=PRO_0000002971;Note=Factor VIIIa light chain
F8	P00451	1999	2038	1668	2351	Chain	ID=PRO_0000002971;Note=Factor VIIIa light chain
F8	P00451	200	223	20	348	Domain	Note=F5/8 type A 1
F8	P00451	200	223	206	348	Domain	Note=Plastocyanin-like 2
F8	P00451	634	704	399	730	Domain	Note=F5/8 type A 2
F8	P00451	634	704	583	730	Domain	Note=Plastocyanin-like 4
F8	P00451	1999	2038	1713	2040	Domain	Note=F5/8 type A 3
F8	P00451	1999	2038	1887	2040	Domain	Note=Plastocyanin-like 6
F8	P00451	2091	2143	2040	2188	Domain	Note=F5/8 type C 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081
F8	P00451	2091	2143	2137	2137	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
F8	P00451	634	704	649	730	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00081,ECO:0000269|PubMed:7613471;Dbxref=PMID:7613471
F8	P00451	2091	2143	2040	2188	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00081,ECO:0000269|PubMed:7613471;Dbxref=PMID:7613471
F8	P00451	2091	2143	9	2143	Alternative sequence	ID=VSP_042657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1427887,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:1427887,PMID:14702039,PMID:15489334
F8	P00451	1999	2038	9	2143	Alternative sequence	ID=VSP_042657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1427887,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:1427887,PMID:14702039,PMID:15489334
F8	P00451	634	704	9	2143	Alternative sequence	ID=VSP_042657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1427887,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:1427887,PMID:14702039,PMID:15489334
F8	P00451	200	223	9	2143	Alternative sequence	ID=VSP_042657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1427887,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:1427887,PMID:14702039,PMID:15489334
F8	P00451	200	223	202	202	Natural variant	ID=VAR_028491;Note=In HEMA%3B mild. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7579394;Dbxref=PMID:7579394
F8	P00451	200	223	202	202	Natural variant	ID=VAR_008123;Note=In HEMA%3B mild. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10408784;Dbxref=PMID:10408784
F8	P00451	200	223	214	214	Natural variant	ID=VAR_028492;Note=In HEMA. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10404764;Dbxref=PMID:10404764
F8	P00451	200	223	217	217	Natural variant	ID=VAR_028493;Note=In HEMA%3B moderate. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7794769;Dbxref=PMID:7794769
F8	P00451	200	223	219	219	Natural variant	ID=VAR_028494;Note=In HEMA. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8644728;Dbxref=PMID:8644728
F8	P00451	200	223	219	219	Natural variant	ID=VAR_028495;Note=In HEMA. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10404764;Dbxref=PMID:10404764
F8	P00451	200	223	220	220	Natural variant	ID=VAR_028496;Note=In HEMA%3B mild. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11858487;Dbxref=PMID:11858487
F8	P00451	200	223	222	222	Natural variant	ID=VAR_001068;Note=In HEMA%3B moderate. D->V;Dbxref=dbSNP:rs137852396
F8	P00451	200	223	223	223	Natural variant	ID=VAR_028497;Note=In HEMA%3B severe. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9569180;Dbxref=PMID:9569180
F8	P00451	634	704	635	635	Natural variant	ID=VAR_028575;Note=In HEMA%3B mild. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11858487;Dbxref=PMID:11858487
F8	P00451	634	704	637	637	Natural variant	ID=VAR_028576;Note=In HEMA%3B severe sporadic/moderate. N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11410838,ECO:0000269|PubMed:7579394;Dbxref=PMID:11410838,PMID:7579394
F8	P00451	634	704	637	637	Natural variant	ID=VAR_065314;Note=In HEMA. N->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184865;Dbxref=PMID:18184865
F8	P00451	634	704	637	637	Natural variant	ID=VAR_028577;Note=In HEMA%3B mild%3B secretion impaired. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10691849;Dbxref=PMID:10691849
F8	P00451	634	704	639	639	Natural variant	ID=VAR_028578;Note=In HEMA%3B moderate. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9341862;Dbxref=PMID:9341862
F8	P00451	634	704	644	644	Natural variant	ID=VAR_001123;Note=In HEMA%3B mild. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9603440;Dbxref=PMID:9603440
F8	P00451	634	704	650	650	Natural variant	ID=VAR_028579;Note=In HEMA%3B mild. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11857744;Dbxref=PMID:11857744
F8	P00451	634	704	653	653	Natural variant	ID=VAR_001124;Note=In HEMA%3B mild. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8449505;Dbxref=dbSNP:rs137852430,PMID:8449505
F8	P00451	634	704	653	653	Natural variant	ID=VAR_001125;Note=In HEMA%3B severe. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12325022,ECO:0000269|PubMed:8449505;Dbxref=dbSNP:rs137852431,PMID:12325022,PMID:8449505
F8	P00451	634	704	659	659	Natural variant	ID=VAR_028580;Note=In HEMA. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8644728;Dbxref=PMID:8644728
F8	P00451	634	704	663	663	Natural variant	ID=VAR_001126;Note=In HEMA%3B mild. A->V;Dbxref=dbSNP:rs137852433
F8	P00451	634	704	664	664	Natural variant	ID=VAR_028581;Note=In HEMA%3B moderate-severe. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10896236;Dbxref=PMID:10896236
F8	P00451	634	704	671	671	Natural variant	ID=VAR_001127;Note=In HEMA%3B severe. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8449505;Dbxref=PMID:8449505
F8	P00451	634	704	677	677	Natural variant	ID=VAR_001128;Note=In HEMA%3B moderate. F->L;Dbxref=dbSNP:rs137852434
F8	P00451	634	704	681	681	Natural variant	ID=VAR_028582;Note=In HEMA%3B mild. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11857744;Dbxref=PMID:11857744
F8	P00451	634	704	682	682	Natural variant	ID=VAR_028583;Note=In HEMA. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9569189;Dbxref=PMID:9569189
F8	P00451	634	704	683	683	Natural variant	ID=VAR_028584;Note=In HEMA%3B severe. Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11554935,ECO:0000269|PubMed:12325022,ECO:0000269|PubMed:12871415;Dbxref=PMID:11554935,PMID:12325022,PMID:12871415
F8	P00451	634	704	683	683	Natural variant	ID=VAR_028585;Note=In HEMA%3B mild. Y->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9886318;Dbxref=PMID:9886318
F8	P00451	634	704	686	686	Natural variant	ID=VAR_028586;Note=In HEMA. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326186;Dbxref=PMID:9326186
F8	P00451	634	704	698	698	Natural variant	ID=VAR_028587;Note=In HEMA. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11554935;Dbxref=PMID:11554935
F8	P00451	634	704	699	699	Natural variant	ID=VAR_028588;Note=In HEMA%3B mild. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11858487;Dbxref=PMID:11858487
F8	P00451	634	704	699	699	Natural variant	ID=VAR_001129;Note=In HEMA%3B severe. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9603440;Dbxref=PMID:9603440
F8	P00451	634	704	701	701	Natural variant	ID=VAR_028589;Note=In HEMA%3B mild. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11858487;Dbxref=PMID:11858487
F8	P00451	1999	2038	2000	2000	Natural variant	ID=VAR_028654;Note=In HEMA%3B moderate-severe. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10896236;Dbxref=PMID:10896236
F8	P00451	1999	2038	2004	2004	Natural variant	ID=VAR_028655;Note=In HEMA%3B sporadic. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11442643;Dbxref=PMID:11442643
F8	P00451	1999	2038	2007	2007	Natural variant	ID=VAR_028656;Note=In HEMA%3B mild. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9886318;Dbxref=PMID:9886318
F8	P00451	1999	2038	2013	2013	Natural variant	ID=VAR_065318;Note=In HEMA. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21371196;Dbxref=PMID:21371196
F8	P00451	1999	2038	2015	2015	Natural variant	ID=VAR_028657;Note=In HEMA%3B moderate. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11858487;Dbxref=PMID:11858487
F8	P00451	1999	2038	2016	2016	Natural variant	ID=VAR_028658;Note=In HEMA%3B severe familial. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11341489;Dbxref=PMID:11341489
F8	P00451	1999	2038	2016	2016	Natural variant	ID=VAR_001175;Note=In HEMA%3B severe/moderate/mild. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10404764,ECO:0000269|PubMed:11341489,ECO:0000269|PubMed:11442643,ECO:0000269|PubMed:11554935,ECO:0000269|PubMed:11858487,ECO:0000269|PubMed:15810915,ECO:0000269|PubMed:7794769,ECO:0000269|PubMed:8644728,ECO:0000269|PubMed:9886318;Dbxref=dbSNP:rs137852453,PMID:10404764,PMID:11341489,PMID:11442643,PMID:11554935,PMID:11858487,PMID:15810915,PMID:7794769,PMID:8644728,PMID:9886318
F8	P00451	1999	2038	2018	2018	Natural variant	ID=VAR_028659;Note=In HEMA%3B moderate. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15810915;Dbxref=dbSNP:rs1406262850,PMID:15810915
F8	P00451	1999	2038	2022	2022	Natural variant	ID=VAR_028660;Note=In HEMA%3B severe. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9886318;Dbxref=PMID:9886318
F8	P00451	1999	2038	2028	2028	Natural variant	ID=VAR_028661;Note=In HEMA. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9569189;Dbxref=PMID:9569189
F8	P00451	1999	2038	2030	2030	Natural variant	ID=VAR_028662;Note=In HEMA%3B mild. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9886318;Dbxref=dbSNP:rs369414658,PMID:9886318
F8	P00451	1999	2038	2035	2035	Natural variant	ID=VAR_028663;Note=In HEMA. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10404764;Dbxref=PMID:10404764
F8	P00451	1999	2038	2036	2036	Natural variant	ID=VAR_015132;Note=In HEMA%3B moderate. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11298607;Dbxref=PMID:11298607
F8	P00451	1999	2038	2038	2038	Natural variant	ID=VAR_001176;Note=In HEMA%3B mild/moderate. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11858487,ECO:0000269|PubMed:9886318;Dbxref=dbSNP:rs137852454,PMID:11858487,PMID:9886318
F8	P00451	2091	2143	2093	2093	Natural variant	ID=VAR_001179;Note=In HEMA%3B mild. D->G;Dbxref=dbSNP:rs137852457
F8	P00451	2091	2143	2093	2093	Natural variant	ID=VAR_028672;Note=In HEMA%3B severe familial. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11442643;Dbxref=PMID:11442643
F8	P00451	2091	2143	2101	2101	Natural variant	ID=VAR_065319;Note=In HEMA. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184865;Dbxref=PMID:18184865
F8	P00451	2091	2143	2105	2105	Natural variant	ID=VAR_001180;Note=In HEMA%3B moderate. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9603440;Dbxref=PMID:9603440
F8	P00451	2091	2143	2106	2106	Natural variant	ID=VAR_028673;Note=In HEMA%3B mild. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910913;Dbxref=PMID:10910913
F8	P00451	2091	2143	2106	2106	Natural variant	ID=VAR_065320;Note=In HEMA. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184865;Dbxref=PMID:18184865
F8	P00451	2091	2143	2106	2106	Natural variant	ID=VAR_028674;Note=In HEMA%3B mild. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9341862;Dbxref=PMID:9341862
F8	P00451	2091	2143	2107	2107	Natural variant	ID=VAR_001181;Note=In HEMA%3B severe. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452104;Dbxref=PMID:9452104
F8	P00451	2091	2143	2109	2109	Natural variant	ID=VAR_028675;Note=In HEMA%3B mild. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910913;Dbxref=PMID:10910913
F8	P00451	2091	2143	2117	2117	Natural variant	ID=VAR_028676;Note=In HEMA. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12325022;Dbxref=PMID:12325022
F8	P00451	2091	2143	2117	2117	Natural variant	ID=VAR_028677;Note=In HEMA%3B mild-moderate%3B affinity for VWF reduced 8-fold. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910910;Dbxref=PMID:10910910
F8	P00451	2091	2143	2119	2119	Natural variant	ID=VAR_028678;Note=In HEMA%3B moderate. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7794769;Dbxref=PMID:7794769
F8	P00451	2091	2143	2120	2120	Natural variant	ID=VAR_028679;Note=In HEMA. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10404764;Dbxref=PMID:10404764
F8	P00451	2091	2143	2120	2120	Natural variant	ID=VAR_001182;Note=In HEMA%3B mild. F->L;Dbxref=dbSNP:rs137852458
F8	P00451	2091	2143	2124	2124	Natural variant	ID=VAR_001183;Note=In HEMA%3B mild. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298607,ECO:0000269|PubMed:9569189;Dbxref=dbSNP:rs137852459,PMID:11298607,PMID:9569189
F8	P00451	2091	2143	2135	2135	Natural variant	ID=VAR_001184;Note=In HEMA%3B severe. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3122181;Dbxref=dbSNP:rs137852366,PMID:3122181
F8	P00451	2091	2143	2138	2138	Natural variant	ID=VAR_001185;Note=In HEMA%3B moderate%3B affinity for VWF reduced 80-fold. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910910;Dbxref=dbSNP:rs137852460,PMID:10910910
F8	P00451	2091	2143	2141	2141	Natural variant	ID=VAR_017340;Note=In HEMA%3B severe. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12930394;Dbxref=PMID:12930394
F8	P00451	2091	2143	2143	2143	Natural variant	ID=VAR_065321;Note=In HEMA. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184865;Dbxref=PMID:18184865
FAM83A	Q86UY5	160	216	1	434	Chain	ID=PRO_0000286813;Note=Protein FAM83A
FAM83A	Q86UY5	160	216	161	216	Alternative sequence	ID=VSP_025187;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
FAM83A	Q86UY5	160	216	160	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAM83A	Q86UY5	160	216	172	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAM83A	Q86UY5	160	216	188	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAM83A	Q86UY5	160	216	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAM83A	Q86UY5	160	216	198	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAM83A	Q86UY5	160	216	213	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAM83A	Q86UY5	160	216	216	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4URJ
FAR1	Q8WVX9	122	181	1	515	Chain	ID=PRO_0000261394;Note=Fatty acyl-CoA reductase 1
FAR1	Q8WVX9	241	256	1	515	Chain	ID=PRO_0000261394;Note=Fatty acyl-CoA reductase 1
FAR1	Q8WVX9	122	181	1	465	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24108123;Dbxref=PMID:24108123
FAR1	Q8WVX9	241	256	1	465	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24108123;Dbxref=PMID:24108123
FAR1	Q8WVX9	122	181	165	169	Natural variant	ID=VAR_072692;Note=In PFCRD%3B results in a complete loss of enzyme activity. EVVYP->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25439727;Dbxref=PMID:25439727
PTK2B	Q14289	295	329	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	738	780	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	829	841	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	911	938	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	295	329	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	738	780	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	829	841	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	911	938	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	295	329	39	359	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2B	Q14289	295	329	39	359	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2B	Q14289	829	841	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	911	938	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	829	841	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	911	938	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	911	938	868	1009	Region	Note=Focal adhesion targeting (FAT)
PTK2B	Q14289	911	938	868	1009	Region	Note=Focal adhesion targeting (FAT)
PTK2B	Q14289	738	780	702	767	Compositional bias	Note=Pro-rich
PTK2B	Q14289	738	780	702	767	Compositional bias	Note=Pro-rich
PTK2B	Q14289	829	841	831	869	Compositional bias	Note=Pro-rich
PTK2B	Q14289	829	841	831	869	Compositional bias	Note=Pro-rich
PTK2B	Q14289	738	780	762	762	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	738	780	762	762	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	738	780	765	765	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
PTK2B	Q14289	738	780	765	765	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
PTK2B	Q14289	829	841	834	834	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	829	841	834	834	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	829	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PTK2B	Q14289	829	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PTK2B	Q14289	738	780	739	780	Alternative sequence	ID=VSP_004981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9545257;Dbxref=PMID:9545257
PTK2B	Q14289	738	780	739	780	Alternative sequence	ID=VSP_004981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9545257;Dbxref=PMID:9545257
PTK2B	Q14289	829	841	838	838	Natural variant	ID=VAR_020284;Note=K->T;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs751019,PMID:19369195,PMID:17344846
PTK2B	Q14289	829	841	838	838	Natural variant	ID=VAR_020284;Note=K->T;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs751019,PMID:19369195,PMID:17344846
PTK2B	Q14289	738	780	780	780	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2B	Q14289	738	780	780	780	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2B	Q14289	295	329	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	314	316	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	314	316	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	911	938	906	927	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	906	927	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	933	962	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	933	962	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
FBXO16	Q8IX29	114	169	1	292	Chain	ID=PRO_0000119896;Note=F-box only protein 16
FBXO16	Q8IX29	33	45	1	292	Chain	ID=PRO_0000119896;Note=F-box only protein 16
FBXO16	Q8IX29	114	169	86	132	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXO16	Q8IX29	33	45	34	45	Alternative sequence	ID=VSP_045600;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBXO3	Q9UK99	270	310	1	471	Chain	ID=PRO_0000119877;Note=F-box only protein 3
FBXO3	Q9UK99	35	64	1	471	Chain	ID=PRO_0000119877;Note=F-box only protein 3
FBXO3	Q9UK99	35	64	10	56	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXO3	Q9UK99	270	310	278	408	Domain	Note=ApaG;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00412
FBXO3	Q9UK99	35	64	36	40	Alternative sequence	ID=VSP_039614;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FBXO3	Q9UK99	270	310	278	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDW
FBXO3	Q9UK99	270	310	284	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDW
FBXO3	Q9UK99	270	310	294	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDW
FBXO3	Q9UK99	270	310	299	302	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDW
FBXO3	Q9UK99	270	310	303	314	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDW
FBXO7	Q9Y3I1	139	215	1	522	Chain	ID=PRO_0000119885;Note=F-box only protein 7
FBXO7	Q9Y3I1	290	322	1	522	Chain	ID=PRO_0000119885;Note=F-box only protein 7
FBXO7	Q9Y3I1	139	215	129	169	Region	Note=Important for interaction with CDK6
FBXO7	Q9Y3I1	139	215	180	324	Region	Note=Important for dimerization and interaction with PSMF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
FBXO7	Q9Y3I1	290	322	180	324	Region	Note=Important for dimerization and interaction with PSMF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
FBXO7	Q9Y3I1	139	215	154	154	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXO7	Q9Y3I1	139	215	169	169	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXO7	Q9Y3I1	139	215	181	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L9H
FBXO7	Q9Y3I1	139	215	195	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L9H
FBXO7	Q9Y3I1	139	215	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L9H
FBXO7	Q9Y3I1	290	322	294	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L9H
FBXO7	Q9Y3I1	290	322	301	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L9H
FBXO7	Q9Y3I1	290	322	313	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L9H
FCGR2A	P12318	35	121	34	317	Chain	ID=PRO_0000015145;Note=Low affinity immunoglobulin gamma Fc region receptor II-a
FCGR2A	P12318	206	247	34	317	Chain	ID=PRO_0000015145;Note=Low affinity immunoglobulin gamma Fc region receptor II-a
FCGR2A	P12318	35	121	34	217	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR2A	P12318	206	247	34	217	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR2A	P12318	206	247	218	240	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR2A	P12318	206	247	241	317	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR2A	P12318	35	121	39	118	Domain	Note=Ig-like C2-type 1
FCGR2A	P12318	35	121	97	97	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10397151;Dbxref=PMID:10397151
FCGR2A	P12318	35	121	62	104	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1FCG,ECO:0000269|PubMed:10331870,ECO:0000269|PubMed:11397093,ECO:0000269|PubMed:19011614;Dbxref=PMID:10331870,PMID:11397093,PMID:19011614
FCGR2A	P12318	35	121	35	35	Alternative sequence	ID=VSP_036865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCGR2A	P12318	35	121	63	63	Natural variant	ID=VAR_054857;Note=Q->R;Dbxref=dbSNP:rs9427398
FCGR2A	P12318	206	247	218	218	Natural variant	ID=VAR_054859;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17851834,PMID:15489334
FCGR2A	P12318	35	121	42	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	50	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	57	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	80	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FCG
FCGR2A	P12318	35	121	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	100	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCGR2A	P12318	35	121	107	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H9V
FCGR2A	P12318	35	121	115	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RY4
FCN2	Q15485	33	71	26	313	Chain	ID=PRO_0000009139;Note=Ficolin-2
FCN2	Q15485	33	71	51	92	Domain	Note=Collagen-like
FCN2	Q15485	33	71	34	71	Alternative sequence	ID=VSP_030027;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCN2	Q15485	33	71	61	61	Sequence conflict	Note=P->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCN2	Q15485	33	71	61	61	Sequence conflict	Note=P->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCAMR	Q8WWV6	56	104	17	532	Chain	ID=PRO_0000331483;Note=High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
FCAMR	Q8WWV6	56	104	17	532	Chain	ID=PRO_0000331483;Note=High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
FCAMR	Q8WWV6	56	104	17	450	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCAMR	Q8WWV6	56	104	17	450	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCAMR	Q8WWV6	56	104	61	169	Domain	Note=Ig-like V-type
FCAMR	Q8WWV6	56	104	61	169	Domain	Note=Ig-like V-type
FCAMR	Q8WWV6	56	104	75	97	Region	Note=Mediates immunoglobulin Fc fragment-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
FCAMR	Q8WWV6	56	104	75	97	Region	Note=Mediates immunoglobulin Fc fragment-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
FCAMR	Q8WWV6	56	104	82	153	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCAMR	Q8WWV6	56	104	82	153	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCHO1	O14526	40	64	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	450	542	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	40	64	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	450	542	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	40	64	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	450	542	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	40	64	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	450	542	1	889	Chain	ID=PRO_0000271759;Note=F-BAR domain only protein 1
FCHO1	O14526	40	64	1	248	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO1	O14526	40	64	1	248	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO1	O14526	40	64	1	248	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO1	O14526	40	64	1	248	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO1	O14526	40	64	1	275	Region	Note=Mediates membrane-binding
FCHO1	O14526	40	64	1	275	Region	Note=Mediates membrane-binding
FCHO1	O14526	40	64	1	275	Region	Note=Mediates membrane-binding
FCHO1	O14526	40	64	1	275	Region	Note=Mediates membrane-binding
FCHO1	O14526	450	542	465	468	Compositional bias	Note=Poly-Ser
FCHO1	O14526	450	542	465	468	Compositional bias	Note=Poly-Ser
FCHO1	O14526	450	542	465	468	Compositional bias	Note=Poly-Ser
FCHO1	O14526	450	542	465	468	Compositional bias	Note=Poly-Ser
FCHO1	O14526	450	542	480	561	Compositional bias	Note=Pro-rich
FCHO1	O14526	450	542	480	561	Compositional bias	Note=Pro-rich
FCHO1	O14526	450	542	480	561	Compositional bias	Note=Pro-rich
FCHO1	O14526	450	542	480	561	Compositional bias	Note=Pro-rich
FCHO1	O14526	450	542	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K285
FCHO1	O14526	450	542	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K285
FCHO1	O14526	450	542	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K285
FCHO1	O14526	450	542	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K285
FCHO1	O14526	40	64	1	50	Alternative sequence	ID=VSP_046906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FCHO1	O14526	40	64	1	50	Alternative sequence	ID=VSP_046906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FCHO1	O14526	40	64	1	50	Alternative sequence	ID=VSP_046906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FCHO1	O14526	40	64	1	50	Alternative sequence	ID=VSP_046906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FCER2	P06734	105	126	1	321	Chain	ID=PRO_0000017391;Note=Low affinity immunoglobulin epsilon Fc receptor membrane-bound form
FCER2	P06734	7	45	1	321	Chain	ID=PRO_0000017391;Note=Low affinity immunoglobulin epsilon Fc receptor membrane-bound form
FCER2	P06734	105	126	1	321	Chain	ID=PRO_0000017391;Note=Low affinity immunoglobulin epsilon Fc receptor membrane-bound form
FCER2	P06734	7	45	1	321	Chain	ID=PRO_0000017391;Note=Low affinity immunoglobulin epsilon Fc receptor membrane-bound form
FCER2	P06734	7	45	1	21	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER2	P06734	7	45	1	21	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER2	P06734	7	45	22	47	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER2	P06734	7	45	22	47	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER2	P06734	105	126	48	321	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER2	P06734	105	126	48	321	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER2	P06734	105	126	90	110	Repeat	.
FCER2	P06734	105	126	90	110	Repeat	.
FCER2	P06734	105	126	111	131	Repeat	.
FCER2	P06734	105	126	111	131	Repeat	.
FCER2	P06734	7	45	17	17	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22615937;Dbxref=PMID:22615937
FCER2	P06734	7	45	17	17	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22615937;Dbxref=PMID:22615937
FCER2	P06734	7	45	18	18	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22615937;Dbxref=PMID:22615937
FCER2	P06734	7	45	18	18	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22615937;Dbxref=PMID:22615937
FGF8	P55075	23	52	23	233	Chain	ID=PRO_0000008970;Note=Fibroblast growth factor 8
FGF8	P55075	23	52	24	52	Alternative sequence	ID=VSP_001525;Note=In isoform FGF-8A. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8700553,ECO:0000303|PubMed:8891346;Dbxref=PMID:15489334,PMID:8700553,PMID:8891346
FGF8	P55075	23	52	24	51	Alternative sequence	ID=VSP_001524;Note=In isoform FGF-8B. EGPGRGPALGRELASLFRAGREPQGVSQ->VTVQSSPNFT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8891346;Dbxref=PMID:8891346
FGF8	P55075	23	52	52	52	Alternative sequence	ID=VSP_001526;Note=In isoform FGF-8F. Q->QVTVQSSPNFTQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11341643,ECO:0000303|PubMed:8700553;Dbxref=PMID:11341643,PMID:8700553
FGF8	P55075	23	52	26	26	Natural variant	ID=VAR_057963;Note=In HH6%3B phenotype consistent with Kallmann syndrome. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18596921;Dbxref=dbSNP:rs137852660,PMID:18596921
FGF8	P55075	23	52	40	40	Natural variant	ID=VAR_057964;Note=In HH6%3B phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism%3B some patients also carry mutations in FGFR1. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18596921,ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs137852661,PMID:18596921,PMID:23643382
FGF8	P55075	23	52	52	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FDB
FHOD1	Q9Y613	835	889	2	1164	Chain	ID=PRO_0000194905;Note=FH1/FH2 domain-containing protein 1
FHOD1	Q9Y613	734	795	2	1164	Chain	ID=PRO_0000194905;Note=FH1/FH2 domain-containing protein 1
FHOD1	Q9Y613	835	889	616	1013	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
FHOD1	Q9Y613	734	795	616	1013	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
FHOD1	Q9Y613	734	795	612	807	Region	Note=Interaction with ROCK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18694941;Dbxref=PMID:18694941
FHOD1	Q9Y613	835	889	884	921	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHOD1	Q9Y613	734	795	745	745	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FHOD1	Q9Y613	734	795	751	751	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FHOD1	Q9Y613	835	889	849	849	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
FKBP4	Q02790	282	344	1	459	Chain	ID=PRO_0000391468;Note=Peptidyl-prolyl cis-trans isomerase FKBP4
FKBP4	Q02790	344	424	1	459	Chain	ID=PRO_0000391468;Note=Peptidyl-prolyl cis-trans isomerase FKBP4
FKBP4	Q02790	282	344	2	459	Chain	ID=PRO_0000075318;Note=Peptidyl-prolyl cis-trans isomerase FKBP4%2C N-terminally processed
FKBP4	Q02790	344	424	2	459	Chain	ID=PRO_0000075318;Note=Peptidyl-prolyl cis-trans isomerase FKBP4%2C N-terminally processed
FKBP4	Q02790	282	344	270	303	Repeat	Note=TPR 1
FKBP4	Q02790	282	344	319	352	Repeat	Note=TPR 2
FKBP4	Q02790	344	424	319	352	Repeat	Note=TPR 2
FKBP4	Q02790	344	424	353	386	Repeat	Note=TPR 3
FKBP4	Q02790	282	344	267	400	Region	Note=Interaction with tubulin;Ontology_term=ECO:0000250;evidence=ECO:0000250
FKBP4	Q02790	344	424	267	400	Region	Note=Interaction with tubulin;Ontology_term=ECO:0000250;evidence=ECO:0000250
FKBP4	Q02790	282	344	282	282	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FKBP4	Q02790	344	424	373	373	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30416
FKBP4	Q02790	282	344	263	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	282	344	286	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	282	344	300	302	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	282	344	309	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	282	344	335	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	344	424	335	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	344	424	353	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	344	424	369	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FKBP4	Q02790	344	424	387	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P5Q
FAM221A	A4D161	22	79	1	298	Chain	ID=PRO_0000295139;Note=Protein FAM221A
FAM221A	A4D161	212	248	1	298	Chain	ID=PRO_0000295139;Note=Protein FAM221A
FAM221A	A4D161	22	79	23	80	Alternative sequence	ID=VSP_026738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM221A	A4D161	212	248	213	248	Alternative sequence	ID=VSP_026739;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM221A	A4D161	212	248	240	240	Natural variant	ID=VAR_033219;Note=S->G;Dbxref=dbSNP:rs35928055
FAM221B	A6H8Z2	284	350	1	402	Chain	ID=PRO_0000309264;Note=Protein FAM221B
FAM221B	A6H8Z2	284	350	248	340	Alternative sequence	ID=VSP_036643;Note=In isoform 3. GLYIGWRCPHYLWDCFRIGDESRCFCGHLLREHRIISDISVPCKVSQCRCFMFCFIPSRPEEVGEFWLKRRATFDPKAWRAQCRCKHSHEEHA->DRIRNSSSGILAPAHLHCDCLYLALSTKPPWCKGALALQAISIKTEEAKPKATSRQALDPDRLWVSTLAGAAPITYGTVSGLGMSPDAFVDTC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FAM221B	A6H8Z2	284	350	341	402	Alternative sequence	ID=VSP_036644;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
F12	P00748	132	176	20	372	Chain	ID=PRO_0000027833;Note=Coagulation factor XIIa heavy chain
F12	P00748	132	176	133	173	Domain	Note=Fibronectin type-I;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00478
F12	P00748	132	176	174	210	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
F12	P00748	132	176	135	163	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23385745;Dbxref=PMID:23385745
F12	P00748	132	176	161	170	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23385745;Dbxref=PMID:23385745
F12	P00748	132	176	142	142	Natural variant	ID=VAR_031500;Note=In FA12D%3B CRM-negative phenotype%3B low levels of accumulation in the cell%3B not secreted. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11776307;Dbxref=PMID:11776307
F12	P00748	132	176	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BDX
F12	P00748	132	176	138	141	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BDX
F12	P00748	132	176	142	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BDX
F12	P00748	132	176	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BDX
F12	P00748	132	176	158	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BDX
F12	P00748	132	176	165	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BDX
FAM3A	P98173	4	42	1	33	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM3A	P98173	4	42	1	33	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM3A	P98173	4	42	1	33	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM3A	P98173	111	128	34	230	Chain	ID=PRO_0000008748;Note=Protein FAM3A
FAM3A	P98173	4	42	34	230	Chain	ID=PRO_0000008748;Note=Protein FAM3A
FAM3A	P98173	111	128	34	230	Chain	ID=PRO_0000008748;Note=Protein FAM3A
FAM3A	P98173	4	42	34	230	Chain	ID=PRO_0000008748;Note=Protein FAM3A
FAM3A	P98173	111	128	34	230	Chain	ID=PRO_0000008748;Note=Protein FAM3A
FAM3A	P98173	4	42	34	230	Chain	ID=PRO_0000008748;Note=Protein FAM3A
FAM3A	P98173	111	128	65	222	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAM3A	P98173	111	128	65	222	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAM3A	P98173	111	128	65	222	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAM3A	P98173	4	42	6	43	Alternative sequence	ID=VSP_046733;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM3A	P98173	4	42	6	43	Alternative sequence	ID=VSP_046733;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM3A	P98173	4	42	6	43	Alternative sequence	ID=VSP_046733;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM3A	P98173	111	128	112	128	Alternative sequence	ID=VSP_042778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM3A	P98173	111	128	112	128	Alternative sequence	ID=VSP_042778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM3A	P98173	111	128	112	128	Alternative sequence	ID=VSP_042778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM3A	P98173	4	42	21	21	Natural variant	ID=VAR_057531;Note=I->M;Dbxref=dbSNP:rs35985994
FAM3A	P98173	4	42	21	21	Natural variant	ID=VAR_057531;Note=I->M;Dbxref=dbSNP:rs35985994
FAM3A	P98173	4	42	21	21	Natural variant	ID=VAR_057531;Note=I->M;Dbxref=dbSNP:rs35985994
FAM3B	P58499	6	54	1	29	Signal peptide	.
FAM3B	P58499	6	54	30	235	Chain	ID=PRO_0000008750;Note=Protein FAM3B
FAM3B	P58499	115	132	30	235	Chain	ID=PRO_0000008750;Note=Protein FAM3B
FAM3B	P58499	115	132	120	120	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM3B	P58499	115	132	69	229	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAM3B	P58499	6	54	7	54	Alternative sequence	ID=VSP_001505;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
FAM3B	P58499	6	54	7	7	Alternative sequence	ID=VSP_001504;Note=In isoform A. G->GSRWACWLTRCLISCFDINVQGRLLVKLRPKPTANTTCPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
FAM3B	P58499	6	54	14	14	Natural variant	ID=VAR_021953;Note=V->M;Dbxref=dbSNP:rs2838012
BRIP1	Q9BX63	858	968	1	1249	Chain	ID=PRO_0000055173;Note=Fanconi anemia group J protein
BRIP1	Q9BX63	598	645	1	1249	Chain	ID=PRO_0000055173;Note=Fanconi anemia group J protein
BRIP1	Q9BX63	858	968	888	1063	Region	Note=Interaction with BRCA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11301010;Dbxref=PMID:11301010
BRIP1	Q9BX63	858	968	927	927	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
BRIP1	Q9BX63	858	968	930	930	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
BRIP1	Q9BX63	858	968	956	956	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRIP1	Q9BX63	598	645	633	633	Natural variant	ID=VAR_052192;Note=I->M;Dbxref=dbSNP:rs28997572
BRIP1	Q9BX63	858	968	919	919	Natural variant	ID=VAR_020905;Note=S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11301010,ECO:0000269|PubMed:11920628,ECO:0000269|PubMed:12565990,ECO:0000269|PubMed:12872252,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16153896,ECO:0000269|PubMed:18987736;Dbxref=dbSNP:rs4986764,PMID:11301010,PMID:11920628,PMID:12565990,PMID:12872252,PMID:14702039,PMID:16153896,PMID:18987736
BRIP1	Q9BX63	858	968	935	935	Natural variant	ID=VAR_020906;Note=V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12872252;Dbxref=dbSNP:rs4988356,PMID:12872252
BRIP1	Q9BX63	598	645	641	641	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FANCL	Q9NW38	230	258	2	375	Chain	ID=PRO_0000055908;Note=E3 ubiquitin-protein ligase FANCL
FANCL	Q9NW38	72	91	2	375	Chain	ID=PRO_0000055908;Note=E3 ubiquitin-protein ligase FANCL
FANCL	Q9NW38	230	258	104	294	Region	Note=UBC-RWD region (URD)
FANCL	Q9NW38	230	258	248	248	Mutagenesis	Note=Impairs interaction with FANCI and FANCD2%3B when associated with A-252%2C A-254 and A-265. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775430;Dbxref=PMID:21775430
FANCL	Q9NW38	230	258	252	252	Mutagenesis	Note=Impairs interaction with FANCI and FANCD2%3B when associated with A-248%2C A-254 and A-265. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775430;Dbxref=PMID:21775430
FANCL	Q9NW38	230	258	254	254	Mutagenesis	Note=Impairs interaction with FANCI and FANCD2%3B when associated with A-248%2C A-252 and A-265. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775430;Dbxref=PMID:21775430
FANCL	Q9NW38	72	91	77	77	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FANCL	Q9NW38	230	258	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZQS
FANCL	Q9NW38	230	258	234	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZQS
FANCL	Q9NW38	230	258	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZQS
FANCL	Q9NW38	230	258	257	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZQS
FASTKD1	Q53R41	691	729	649	692	Alternative sequence	ID=VSP_024617;Note=In isoform 2. ILSPSRSARVQFHLMELNRSVCLECPEFQIPWFHDRFCQQYNKG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FASTKD1	Q53R41	648	691	649	692	Alternative sequence	ID=VSP_024617;Note=In isoform 2. ILSPSRSARVQFHLMELNRSVCLECPEFQIPWFHDRFCQQYNKG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FASTKD1	Q53R41	191	323	213	213	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
FASTKD1	Q53R41	191	323	228	228	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FASTKD1	Q53R41	191	323	288	288	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FASTKD1	Q53R41	191	323	293	293	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FANCG	O15287	493	545	1	622	Chain	ID=PRO_0000106292;Note=Fanconi anemia group G protein
FANCG	O15287	259	308	1	622	Chain	ID=PRO_0000106292;Note=Fanconi anemia group G protein
FANCG	O15287	259	308	246	279	Repeat	Note=TPR 1
FANCG	O15287	493	545	514	547	Repeat	Note=TPR 4
FANCG	O15287	259	308	294	294	Natural variant	ID=VAR_021103;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs17880082
FANCG	O15287	259	308	297	297	Natural variant	ID=VAR_020311;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2237857
FANCG	O15287	493	545	513	513	Natural variant	ID=VAR_021107;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs17885240
FASTK	Q14296	168	228	1	549	Chain	ID=PRO_0000087196;Note=Fas-activated serine/threonine kinase
FASTK	Q14296	27	168	1	549	Chain	ID=PRO_0000087196;Note=Fas-activated serine/threonine kinase
FASTK	Q14296	168	228	189	195	Compositional bias	Note=Poly-Pro
FASTK	Q14296	27	168	1	34	Alternative sequence	ID=VSP_058246;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:25704814;Dbxref=PMID:25704814
FASTK	Q14296	27	168	28	28	Alternative sequence	ID=VSP_042746;Note=In isoform 2. W->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FASTK	Q14296	168	228	29	169	Alternative sequence	ID=VSP_042747;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FASTK	Q14296	27	168	29	169	Alternative sequence	ID=VSP_042747;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FASTK	Q14296	168	228	202	228	Alternative sequence	ID=VSP_044811;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
FASTK	Q14296	27	168	35	35	Mutagenesis	Note=Abolishes isoform 4 expression. M->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25704814;Dbxref=PMID:25704814
FBLN2	P98095	684	718	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	718	763	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	763	809	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	809	857	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	857	900	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	900	942	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	942	981	28	1184	Chain	ID=PRO_0000007568;Note=Fibulin-2
FBLN2	P98095	684	718	679	718	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	718	763	679	718	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	718	763	719	763	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	763	809	719	763	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	763	809	764	809	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	809	857	764	809	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	809	857	810	857	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	857	900	810	857	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	857	900	858	900	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	900	942	858	900	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	900	942	901	942	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	942	981	901	942	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	942	981	943	981	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN2	P98095	684	718	683	693	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	684	718	689	702	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	684	718	704	717	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	718	763	723	736	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	718	763	730	745	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	718	763	751	762	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	763	809	768	781	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	763	809	775	790	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	763	809	796	808	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	809	857	814	827	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	809	857	821	836	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	809	857	843	856	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	857	900	862	875	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	857	900	869	884	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	857	900	886	899	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	900	942	905	917	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	900	942	913	926	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	900	942	928	941	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	942	981	947	956	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	942	981	952	965	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	942	981	967	980	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN2	P98095	684	718	718	718	Alternative sequence	ID=VSP_041404;Note=In isoform 2. E->EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
FBLN2	P98095	718	763	718	718	Alternative sequence	ID=VSP_041404;Note=In isoform 2. E->EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
FBLN2	P98095	809	857	854	854	Natural variant	ID=VAR_059268;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7806230;Dbxref=dbSNP:rs9843344,PMID:7806230
FBXW10	Q5XX13	616	668	1	1052	Chain	ID=PRO_0000315834;Note=F-box/WD repeat-containing protein 10
FBXW10	Q5XX13	759	778	1	1052	Chain	ID=PRO_0000315834;Note=F-box/WD repeat-containing protein 10
FBXW10	Q5XX13	616	668	611	652	Repeat	Note=WD 7
FBXW10	Q5XX13	616	668	617	669	Alternative sequence	ID=VSP_030728;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
FBXW10	Q5XX13	759	778	760	779	Alternative sequence	ID=VSP_030729;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBXW10	Q5XX13	616	668	638	638	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXO25	Q8TCJ0	29	60	1	367	Chain	ID=PRO_0000119911;Note=F-box only protein 25
FBXO25	Q8TCJ0	153	214	1	367	Chain	ID=PRO_0000119911;Note=F-box only protein 25
FBXO25	Q8TCJ0	214	262	1	367	Chain	ID=PRO_0000119911;Note=F-box only protein 25
FBXO25	Q8TCJ0	214	262	226	274	Domain	Note=F-box
FBXO25	Q8TCJ0	29	60	1	83	Region	Note=Interaction with beta-actin
FBXO25	Q8TCJ0	29	60	1	67	Alternative sequence	ID=VSP_013060;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBXO25	Q8TCJ0	29	60	36	36	Natural variant	ID=VAR_049043;Note=N->D;Dbxref=dbSNP:rs17665340
FBXO25	Q8TCJ0	29	60	38	38	Natural variant	ID=VAR_061167;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs10090550,PMID:15489334
FBXO25	Q8TCJ0	214	262	244	244	Mutagenesis	Note=Loss of SKP1-binding. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16278047;Dbxref=PMID:16278047
FBXO44	Q9H4M3	131	162	1	255	Chain	ID=PRO_0000119945;Note=F-box only protein 44
FBXO44	Q9H4M3	131	162	1	255	Chain	ID=PRO_0000119945;Note=F-box only protein 44
FBXO44	Q9H4M3	131	162	71	252	Domain	Note=FBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00482
FBXO44	Q9H4M3	131	162	71	252	Domain	Note=FBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00482
FBXO44	Q9H4M3	131	162	123	224	Alternative sequence	ID=VSP_011346;Note=In isoform 2. KKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIW->RSQARLRVQVPAVRSAPVVRARASGDLPARPGDHPAEERCQVEGGLPHILQLPARRPLHLVSARRRGHSLLGRLVRPEGHQQQHHHRAPAALTPPEPPSAEP;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334
FBXO44	Q9H4M3	131	162	123	224	Alternative sequence	ID=VSP_011346;Note=In isoform 2. KKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIW->RSQARLRVQVPAVRSAPVVRARASGDLPARPGDHPAEERCQVEGGLPHILQLPARRPLHLVSARRRGHSLLGRLVRPEGHQQQHHHRAPAALTPPEPPSAEP;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334
FBXO44	Q9H4M3	131	162	133	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	133	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	142	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	142	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	148	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	148	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	157	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXO44	Q9H4M3	131	162	157	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSO
FBXW8	Q8N3Y1	141	196	1	598	Chain	ID=PRO_0000050997;Note=F-box/WD repeat-containing protein 8
FBXW8	Q8N3Y1	344	413	1	598	Chain	ID=PRO_0000050997;Note=F-box/WD repeat-containing protein 8
FBXW8	Q8N3Y1	141	196	113	159	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXW8	Q8N3Y1	141	196	192	192	Natural variant	ID=VAR_060326;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10531037,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs4076700,PMID:10531037,PMID:15489334
FBXW8	Q8N3Y1	344	413	380	380	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCHSD2	O94868	436	481	1	740	Chain	ID=PRO_0000278214;Note=F-BAR and double SH3 domains protein 2
FCHSD2	O94868	382	436	1	740	Chain	ID=PRO_0000278214;Note=F-BAR and double SH3 domains protein 2
FCHSD2	O94868	347	382	1	740	Chain	ID=PRO_0000278214;Note=F-BAR and double SH3 domains protein 2
FCHSD2	O94868	308	347	1	740	Chain	ID=PRO_0000278214;Note=F-BAR and double SH3 domains protein 2
FCHSD2	O94868	276	308	1	740	Chain	ID=PRO_0000278214;Note=F-BAR and double SH3 domains protein 2
FCHSD2	O94868	276	308	8	282	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHSD2	O94868	436	481	469	530	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FCHSD2	O94868	382	436	356	397	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FCHSD2	O94868	347	382	356	397	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FCHSD2	O94868	436	481	470	476	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DL5
HAO2	Q9NYQ3	187	257	1	351	Chain	ID=PRO_0000206320;Note=Hydroxyacid oxidase 2
HAO2	Q9NYQ3	187	257	2	351	Domain	Note=FMN hydroxy acid dehydrogenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00683
HAO2	Q9NYQ3	187	257	246	246	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00683
HAO2	Q9NYQ3	187	257	222	222	Binding site	Note=FMN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00683
HAO2	Q9NYQ3	187	257	249	249	Binding site	Note=Substrate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00683
HAO2	Q9NYQ3	187	257	221	221	Natural variant	ID=VAR_049088;Note=L->M;Dbxref=dbSNP:rs6661625
FBXL7	Q9UJT9	42	246	1	491	Chain	ID=PRO_0000119849;Note=F-box/LRR-repeat protein 7
FBXL7	Q9UJT9	42	246	111	157	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXL7	Q9UJT9	42	246	170	195	Repeat	Note=LRR 1
FBXL7	Q9UJT9	42	246	196	221	Repeat	Note=LRR 2
FBXL7	Q9UJT9	42	246	222	247	Repeat	Note=LRR 3
FBXL7	Q9UJT9	42	246	1	47	Alternative sequence	ID=VSP_054751;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HAUS7	Q99871	320	379	1	368	Chain	ID=PRO_0000097552;Note=HAUS augmin-like complex subunit 7
HAUS7	Q99871	320	379	320	320	Alternative sequence	ID=VSP_037669;Note=In isoform 2. Q->QIPRGQPKKPALVTMTTVPTCATLPLAQGFRDVHFGFLSERLRAFQPLTGWSCETPRSGM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HAUS7	Q99871	320	379	321	339	Alternative sequence	ID=VSP_040920;Note=In isoform 3. LLQVVMAVADTSAKAVETV->VRVPFPSPLTAPSPVHSD;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
HAUS7	Q99871	320	379	340	368	Alternative sequence	ID=VSP_040921;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
HAVCR2	Q8TDQ0	131	159	22	301	Chain	ID=PRO_0000042101;Note=Hepatitis A virus cellular receptor 2
HAVCR2	Q8TDQ0	131	159	22	202	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HAVCR2	Q8TDQ0	131	159	145	145	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22171320;Dbxref=PMID:22171320
HAVCR2	Q8TDQ0	131	159	132	142	Alternative sequence	ID=VSP_017287;Note=In isoform 2. AKVTPAPTRQR->GEWTFACHLYE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HAVCR2	Q8TDQ0	131	159	143	301	Alternative sequence	ID=VSP_017288;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HAVCR2	Q8TDQ0	131	159	140	140	Natural variant	ID=VAR_025342;Note=R->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11823861,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2,ECO:0000269|Ref.3,ECO:0000269|Ref.6;Dbxref=dbSNP:rs1036199,PMID:11823861,PMID:14702039,PMID:15489334
FEZ1	Q99689	365	387	1	392	Chain	ID=PRO_0000189525;Note=Fasciculation and elongation protein zeta-1
FEZ1	Q99689	313	340	1	392	Chain	ID=PRO_0000189525;Note=Fasciculation and elongation protein zeta-1
FEZ1	Q99689	137	166	1	392	Chain	ID=PRO_0000189525;Note=Fasciculation and elongation protein zeta-1
FEZ1	Q99689	137	166	140	145	Compositional bias	Note=Poly-Glu
FEZ1	Q99689	313	340	316	316	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K0X8
FEZ1	Q99689	365	387	105	392	Alternative sequence	ID=VSP_006951;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9096408;Dbxref=PMID:9096408
FEZ1	Q99689	313	340	105	392	Alternative sequence	ID=VSP_006951;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9096408;Dbxref=PMID:9096408
FEZ1	Q99689	137	166	105	392	Alternative sequence	ID=VSP_006951;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9096408;Dbxref=PMID:9096408
FFAR4	Q5NUL3	232	248	1	377	Chain	ID=PRO_0000069610;Note=Free fatty acid receptor 4
FFAR4	Q5NUL3	232	248	226	284	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FFAR4	Q5NUL3	232	248	233	248	Alternative sequence	ID=VSP_013684;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12679517,ECO:0000303|PubMed:15489334;Dbxref=PMID:12679517,PMID:15489334
EXOG	Q9Y2C4	54	104	42	368	Chain	ID=PRO_0000178669;Note=Nuclease EXOG%2C mitochondrial
EXOG	Q9Y2C4	54	104	1	140	Alternative sequence	ID=VSP_034506;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231028,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231028,PMID:14702039,PMID:15489334
EXOG	Q9Y2C4	54	104	55	104	Alternative sequence	ID=VSP_041214;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXOG	Q9Y2C4	54	104	62	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T40
EXOG	Q9Y2C4	54	104	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A1N
EXOG	Q9Y2C4	54	104	78	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T40
EXOG	Q9Y2C4	54	104	86	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T40
EXOG	Q9Y2C4	54	104	90	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T40
EXOG	Q9Y2C4	54	104	100	103	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T40
EXT1	Q16394	544	574	1	746	Chain	ID=PRO_0000149648;Note=Exostosin-1
EXT1	Q16394	388	428	1	746	Chain	ID=PRO_0000149648;Note=Exostosin-1
EXT1	Q16394	544	574	29	746	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT1	Q16394	388	428	29	746	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT1	Q16394	544	574	544	549	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT1	Q16394	544	574	565	567	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT1	Q16394	544	574	567	567	Metal binding	Note=Manganese%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	209	247	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	391	435	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	554	602	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	602	645	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	209	247	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	391	435	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	554	602	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	602	645	1	718	Chain	ID=PRO_0000149651;Note=Exostosin-2
EXT2	Q93063	209	247	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	391	435	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	554	602	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	602	645	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	209	247	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	391	435	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	554	602	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	602	645	47	718	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	602	645	624	628	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	602	645	624	628	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	602	645	628	628	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	602	645	628	628	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	554	602	569	569	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	554	602	569	569	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	602	645	637	637	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	602	645	637	637	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXT2	Q93063	602	645	626	676	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	602	645	626	676	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ES89
EXT2	Q93063	391	435	392	411	Alternative sequence	ID=VSP_001798;Note=In isoform 2. ARWFWEAYFQSIKAIALATL->LFMEPARRENWSAANHQMNSLIWPREQWDS;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXT2	Q93063	391	435	392	411	Alternative sequence	ID=VSP_001798;Note=In isoform 2. ARWFWEAYFQSIKAIALATL->LFMEPARRENWSAANHQMNSLIWPREQWDS;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXT2	Q93063	209	247	223	223	Natural variant	ID=VAR_012827;Note=In EXT2. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10738008;Dbxref=dbSNP:rs764379119,PMID:10738008
EXT2	Q93063	209	247	223	223	Natural variant	ID=VAR_012827;Note=In EXT2. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10738008;Dbxref=dbSNP:rs764379119,PMID:10738008
EXT2	Q93063	209	247	227	227	Natural variant	ID=VAR_002378;Note=In EXT2%3B no effect on oligomeric complex formation with EXT1. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11169766,ECO:0000269|PubMed:11432960,ECO:0000269|PubMed:19344451,ECO:0000269|PubMed:9326317;Dbxref=dbSNP:rs121918280,PMID:11169766,PMID:11432960,PMID:19344451,PMID:9326317
EXT2	Q93063	209	247	227	227	Natural variant	ID=VAR_002378;Note=In EXT2%3B no effect on oligomeric complex formation with EXT1. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11169766,ECO:0000269|PubMed:11432960,ECO:0000269|PubMed:19344451,ECO:0000269|PubMed:9326317;Dbxref=dbSNP:rs121918280,PMID:11169766,PMID:11432960,PMID:19344451,PMID:9326317
EXT2	Q93063	554	602	576	576	Natural variant	ID=VAR_012829;Note=In osteochondroma. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11668521;Dbxref=dbSNP:rs373582542,PMID:11668521
EXT2	Q93063	554	602	576	576	Natural variant	ID=VAR_012829;Note=In osteochondroma. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11668521;Dbxref=dbSNP:rs373582542,PMID:11668521
EXT2	Q93063	554	602	568	568	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXT2	Q93063	554	602	568	568	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM120C	Q9NX05	809	879	1	1096	Chain	ID=PRO_0000221628;Note=Constitutive coactivator of PPAR-gamma-like protein 2
FAM120C	Q9NX05	809	879	239	1096	Alternative sequence	ID=VSP_010520;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
PFKFB3	Q16875	147	166	1	520	Chain	ID=PRO_0000179968;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 3
PFKFB3	Q16875	326	361	1	520	Chain	ID=PRO_0000179968;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 3
PFKFB3	Q16875	447	505	1	520	Chain	ID=PRO_0000179968;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 3
PFKFB3	Q16875	147	166	164	169	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16316985,ECO:0000269|PubMed:17499765,ECO:0000269|PubMed:22275052;Dbxref=PMID:16316985,PMID:17499765,PMID:22275052
PFKFB3	Q16875	326	361	345	348	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953
PFKFB3	Q16875	147	166	1	245	Region	Note=6-phosphofructo-2-kinase
PFKFB3	Q16875	326	361	246	520	Region	Note=Fructose-2%2C6-bisphosphatase
PFKFB3	Q16875	447	505	246	520	Region	Note=Fructose-2%2C6-bisphosphatase
PFKFB3	Q16875	147	166	155	155	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255
PFKFB3	Q16875	326	361	334	334	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25849762;Dbxref=PMID:25849762
PFKFB3	Q16875	326	361	348	348	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25849762;Dbxref=PMID:25849762
PFKFB3	Q16875	326	361	352	352	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25849762;Dbxref=PMID:25849762
PFKFB3	Q16875	447	505	461	461	Modified residue	Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12065600;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:12065600
PFKFB3	Q16875	447	505	463	463	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PFKFB3	Q16875	447	505	467	467	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
PFKFB3	Q16875	447	505	471	471	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000250;evidence=ECO:0000250
PFKFB3	Q16875	147	166	147	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	147	166	157	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	147	166	165	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	326	361	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	326	361	334	340	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	326	361	342	350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	326	361	352	354	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AK0
PFKFB3	Q16875	447	505	455	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AXN
FAM86B1	Q8N7N1	53	80	1	296	Chain	ID=PRO_0000307251;Note=Putative protein N-methyltransferase FAM86B1
F5	P12259	1806	1866	29	2224	Chain	ID=PRO_0000002978;Note=Coagulation factor V
F5	P12259	1806	1866	1574	2224	Chain	ID=PRO_0000002981;Note=Coagulation factor V light chain
F5	P12259	1806	1866	1578	1907	Domain	Note=F5/8 type A 3
F5	P12259	1806	1866	1761	1907	Domain	Note=Plastocyanin-like 6
F5	P12259	1806	1866	1843	1843	Metal binding	Note=Copper;Ontology_term=ECO:0000250;evidence=ECO:0000250
F5	P12259	1806	1866	1845	1845	Metal binding	Note=Copper;Ontology_term=ECO:0000250;evidence=ECO:0000250
F5	P12259	1806	1866	1820	1820	Natural variant	ID=VAR_013898;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs6026,PMID:10391209
FAAH	O00519	103	148	1	579	Chain	ID=PRO_0000105264;Note=Fatty-acid amide hydrolase 1
FAAH	O00519	103	148	30	403	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
FAAH	O00519	103	148	142	142	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
FAAH	O00519	103	148	129	129	Natural variant	ID=VAR_013563;Note=Polymorphism associated with susceptibility to drug abuse%3B the mutant enzyme is more sensitive to proteolytic degradation%3B displays reduced cellular expression probably due to a post-translational mechanism preceding productive folding. P->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12060782,ECO:0000269|PubMed:15254019,ECO:0000269|PubMed:16972078,ECO:0000269|PubMed:23556448,ECO:0000269|Ref.3,ECO:0000269|Ref.5;Dbxref=dbSNP:rs324420,PMID:12060782,PMID:15254019,PMID:16972078,PMID:23556448
FAN1	Q9Y2M0	604	647	1	1017	Chain	ID=PRO_0000311224;Note=Fanconi-associated nuclease 1
FAN1	Q9Y2M0	724	779	1	1017	Chain	ID=PRO_0000311224;Note=Fanconi-associated nuclease 1
FAN1	Q9Y2M0	864	929	1	1017	Chain	ID=PRO_0000311224;Note=Fanconi-associated nuclease 1
FAN1	Q9Y2M0	929	972	1	1017	Chain	ID=PRO_0000311224;Note=Fanconi-associated nuclease 1
FAN1	Q9Y2M0	864	929	895	1007	Domain	Note=VRR-NUC
FAN1	Q9Y2M0	929	972	895	1007	Domain	Note=VRR-NUC
FAN1	Q9Y2M0	929	972	960	960	Metal binding	Note=Magnesium or manganese 1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25430771;Dbxref=PMID:25430771
FAN1	Q9Y2M0	929	972	960	960	Metal binding	Note=Magnesium or manganese 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25430771;Dbxref=PMID:25430771
FAN1	Q9Y2M0	604	647	534	1017	Alternative sequence	ID=VSP_029430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FAN1	Q9Y2M0	724	779	534	1017	Alternative sequence	ID=VSP_029430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FAN1	Q9Y2M0	864	929	534	1017	Alternative sequence	ID=VSP_029430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FAN1	Q9Y2M0	929	972	534	1017	Alternative sequence	ID=VSP_029430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FAN1	Q9Y2M0	864	929	871	871	Natural variant	ID=VAR_068958;Note=In KMIN%3B partially complement cell survival upon exposure to mitomycin C. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22772369;Dbxref=PMID:22772369
FAN1	Q9Y2M0	864	929	929	929	Natural variant	ID=VAR_068959;Note=In KMIN. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22772369;Dbxref=PMID:22772369
FAN1	Q9Y2M0	929	972	929	929	Natural variant	ID=VAR_068959;Note=In KMIN. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22772369;Dbxref=PMID:22772369
FAN1	Q9Y2M0	929	972	937	937	Natural variant	ID=VAR_068960;Note=In KMIN. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22772369;Dbxref=dbSNP:rs1270571213,PMID:22772369
FAN1	Q9Y2M0	929	972	960	960	Natural variant	ID=VAR_068961;Note=In KMIN. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22772369;Dbxref=dbSNP:rs751703979,PMID:22772369
FAN1	Q9Y2M0	864	929	864	864	Mutagenesis	Note=Loss of nuclease activity%3B when associated with A-960%3B A-975 and A-977. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20603073;Dbxref=PMID:20603073
FAN1	Q9Y2M0	929	972	952	952	Mutagenesis	Note=Strongly reduced affinity for sites that have a 5'-terminal phosphate anchor at a flap of 1 nucleotide%3B when associated with A-706. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25430771;Dbxref=PMID:25430771
FAN1	Q9Y2M0	929	972	960	960	Mutagenesis	Note=Loss of nuclease activity. Loss of nuclease activity%3B when associated with A-864%3B A-975 and A-977. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20603016,ECO:0000269|PubMed:20603073,ECO:0000269|PubMed:20671156;Dbxref=PMID:20603016,PMID:20603073,PMID:20671156
FAN1	Q9Y2M0	604	647	599	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	604	647	624	639	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	604	647	640	643	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	604	647	645	651	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	724	779	722	734	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	724	779	740	754	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	724	779	757	759	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	724	779	761	765	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	724	779	778	783	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	864	929	868	871	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	864	929	874	877	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	864	929	880	891	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	864	929	895	909	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	864	929	921	924	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	864	929	925	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	929	972	925	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	929	972	951	955	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	929	972	960	964	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	929	972	966	968	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FAN1	Q9Y2M0	929	972	971	977	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REC
FBN3	Q75N90	2484	2527	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2293	2362	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2206	2251	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2061	2083	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1928	1968	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1885	1928	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1804	1846	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1720	1762	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1444	1485	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1403	1444	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	868	910	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	180	246	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	116	148	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2484	2527	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2293	2362	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2206	2251	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2061	2083	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1928	1968	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1885	1928	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1804	1846	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1720	1762	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1444	1485	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1403	1444	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	868	910	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	180	246	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	116	148	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2484	2527	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2293	2362	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2206	2251	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	2061	2083	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1928	1968	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1885	1928	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1804	1846	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1720	1762	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1444	1485	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	1403	1444	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	868	910	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	180	246	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	116	148	49	2689	Chain	ID=PRO_0000007586;Note=Fibrillin-3
FBN3	Q75N90	116	148	147	179	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	116	148	147	179	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	116	148	147	179	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	180	246	185	237	Domain	Note=TB 1
FBN3	Q75N90	180	246	185	237	Domain	Note=TB 1
FBN3	Q75N90	180	246	185	237	Domain	Note=TB 1
FBN3	Q75N90	868	910	869	910	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	869	910	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	869	910	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1362	1403	Domain	Note=EGF-like 21%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1362	1403	Domain	Note=EGF-like 21%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1362	1403	Domain	Note=EGF-like 21%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1404	1444	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1404	1444	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1404	1444	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1404	1444	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1404	1444	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1404	1444	Domain	Note=EGF-like 22%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1445	1485	Domain	Note=EGF-like 23%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1445	1485	Domain	Note=EGF-like 23%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1445	1485	Domain	Note=EGF-like 23%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1721	1762	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1721	1762	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1721	1762	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1763	1804	Domain	Note=EGF-like 27%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1763	1804	Domain	Note=EGF-like 27%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1763	1804	Domain	Note=EGF-like 27%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1805	1846	Domain	Note=EGF-like 28;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1805	1846	Domain	Note=EGF-like 28;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1805	1846	Domain	Note=EGF-like 28;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1847	1885	Domain	Note=EGF-like 29%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1847	1885	Domain	Note=EGF-like 29%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1847	1885	Domain	Note=EGF-like 29%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1886	1928	Domain	Note=EGF-like 30%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1886	1928	Domain	Note=EGF-like 30%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1886	1928	Domain	Note=EGF-like 30%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1886	1928	Domain	Note=EGF-like 30%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1886	1928	Domain	Note=EGF-like 30%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1886	1928	Domain	Note=EGF-like 30%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1929	1968	Domain	Note=EGF-like 31%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1929	1968	Domain	Note=EGF-like 31%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1929	1968	Domain	Note=EGF-like 31%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2061	2083	2015	2068	Domain	Note=TB 8
FBN3	Q75N90	2061	2083	2015	2068	Domain	Note=TB 8
FBN3	Q75N90	2061	2083	2015	2068	Domain	Note=TB 8
FBN3	Q75N90	2206	2251	2166	2206	Domain	Note=EGF-like 35%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2166	2206	Domain	Note=EGF-like 35%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2166	2206	Domain	Note=EGF-like 35%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2207	2251	Domain	Note=EGF-like 36%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2207	2251	Domain	Note=EGF-like 36%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2207	2251	Domain	Note=EGF-like 36%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2293	2362	2252	2293	Domain	Note=EGF-like 37%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2293	2362	2252	2293	Domain	Note=EGF-like 37%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2293	2362	2252	2293	Domain	Note=EGF-like 37%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2293	2362	2298	2351	Domain	Note=TB 9
FBN3	Q75N90	2293	2362	2298	2351	Domain	Note=TB 9
FBN3	Q75N90	2293	2362	2298	2351	Domain	Note=TB 9
FBN3	Q75N90	2484	2527	2446	2484	Domain	Note=EGF-like 40%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2446	2484	Domain	Note=EGF-like 40%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2446	2484	Domain	Note=EGF-like 40%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2485	2527	Domain	Note=EGF-like 41%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2485	2527	Domain	Note=EGF-like 41%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2485	2527	Domain	Note=EGF-like 41%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1442	1442	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBN3	Q75N90	1403	1444	1442	1442	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBN3	Q75N90	1403	1444	1442	1442	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBN3	Q75N90	868	910	873	885	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	873	885	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	873	885	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	880	894	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	880	894	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	880	894	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	896	909	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	896	909	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	868	910	896	909	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1408	1419	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1408	1419	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1408	1419	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1414	1428	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1414	1428	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1414	1428	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1430	1443	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1430	1443	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1403	1444	1430	1443	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1449	1460	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1449	1460	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1449	1460	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1455	1469	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1455	1469	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1455	1469	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1471	1484	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1471	1484	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1444	1485	1471	1484	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1725	1737	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1725	1737	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1725	1737	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1732	1746	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1732	1746	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1732	1746	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1748	1761	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1748	1761	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1720	1762	1748	1761	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1809	1821	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1809	1821	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1809	1821	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1816	1830	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1816	1830	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1816	1830	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1832	1845	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1832	1845	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1804	1846	1832	1845	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1890	1903	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1890	1903	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1890	1903	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1898	1912	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1898	1912	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1898	1912	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1914	1927	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1914	1927	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1885	1928	1914	1927	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1933	1945	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1933	1945	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1933	1945	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1940	1954	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1940	1954	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1940	1954	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1956	1967	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1956	1967	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	1928	1968	1956	1967	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2211	2225	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2211	2225	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2211	2225	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2218	2234	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2218	2234	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2218	2234	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2236	2250	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2236	2250	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2206	2251	2236	2250	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2489	2502	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2489	2502	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2489	2502	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2496	2511	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2496	2511	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2496	2511	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2513	2526	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2513	2526	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	2484	2527	2513	2526	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN3	Q75N90	116	148	119	119	Natural variant	ID=VAR_019493;Note=G->A;Dbxref=dbSNP:rs3813773
FBN3	Q75N90	116	148	119	119	Natural variant	ID=VAR_019493;Note=G->A;Dbxref=dbSNP:rs3813773
FBN3	Q75N90	116	148	119	119	Natural variant	ID=VAR_019493;Note=G->A;Dbxref=dbSNP:rs3813773
FBN3	Q75N90	868	910	868	868	Natural variant	ID=VAR_055739;Note=D->N;Dbxref=dbSNP:rs35025963
FBN3	Q75N90	868	910	868	868	Natural variant	ID=VAR_055739;Note=D->N;Dbxref=dbSNP:rs35025963
FBN3	Q75N90	868	910	868	868	Natural variant	ID=VAR_055739;Note=D->N;Dbxref=dbSNP:rs35025963
FBN3	Q75N90	1403	1444	1431	1431	Natural variant	ID=VAR_055742;Note=N->I;Dbxref=dbSNP:rs17160194
FBN3	Q75N90	1403	1444	1431	1431	Natural variant	ID=VAR_055742;Note=N->I;Dbxref=dbSNP:rs17160194
FBN3	Q75N90	1403	1444	1431	1431	Natural variant	ID=VAR_055742;Note=N->I;Dbxref=dbSNP:rs17160194
FBN3	Q75N90	1804	1846	1806	1806	Natural variant	ID=VAR_019502;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11347906;Dbxref=dbSNP:rs3829817,PMID:11347906
FBN3	Q75N90	1804	1846	1806	1806	Natural variant	ID=VAR_019502;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11347906;Dbxref=dbSNP:rs3829817,PMID:11347906
FBN3	Q75N90	1804	1846	1806	1806	Natural variant	ID=VAR_019502;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11347906;Dbxref=dbSNP:rs3829817,PMID:11347906
FBN3	Q75N90	1885	1928	1904	1904	Natural variant	ID=VAR_055744;Note=L->F;Dbxref=dbSNP:rs12608849
FBN3	Q75N90	1885	1928	1904	1904	Natural variant	ID=VAR_055744;Note=L->F;Dbxref=dbSNP:rs12608849
FBN3	Q75N90	1885	1928	1904	1904	Natural variant	ID=VAR_055744;Note=L->F;Dbxref=dbSNP:rs12608849
FBN3	Q75N90	1885	1928	1904	1904	Natural variant	ID=VAR_019504;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221638;Dbxref=dbSNP:rs12608849,PMID:15221638
FBN3	Q75N90	1885	1928	1904	1904	Natural variant	ID=VAR_019504;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221638;Dbxref=dbSNP:rs12608849,PMID:15221638
FBN3	Q75N90	1885	1928	1904	1904	Natural variant	ID=VAR_019504;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221638;Dbxref=dbSNP:rs12608849,PMID:15221638
FBN3	Q75N90	1928	1968	1939	1939	Natural variant	ID=VAR_055745;Note=T->N;Dbxref=dbSNP:rs7245558
FBN3	Q75N90	1928	1968	1939	1939	Natural variant	ID=VAR_055745;Note=T->N;Dbxref=dbSNP:rs7245558
FBN3	Q75N90	1928	1968	1939	1939	Natural variant	ID=VAR_055745;Note=T->N;Dbxref=dbSNP:rs7245558
FBN3	Q75N90	1928	1968	1958	1958	Natural variant	ID=VAR_019505;Note=P->H;Dbxref=dbSNP:rs7245429
FBN3	Q75N90	1928	1968	1958	1958	Natural variant	ID=VAR_019505;Note=P->H;Dbxref=dbSNP:rs7245429
FBN3	Q75N90	1928	1968	1958	1958	Natural variant	ID=VAR_019505;Note=P->H;Dbxref=dbSNP:rs7245429
FBN3	Q75N90	1928	1968	1966	1966	Natural variant	ID=VAR_055746;Note=H->D;Dbxref=dbSNP:rs34167077
FBN3	Q75N90	1928	1968	1966	1966	Natural variant	ID=VAR_055746;Note=H->D;Dbxref=dbSNP:rs34167077
FBN3	Q75N90	1928	1968	1966	1966	Natural variant	ID=VAR_055746;Note=H->D;Dbxref=dbSNP:rs34167077
FBN3	Q75N90	2293	2362	2314	2314	Natural variant	ID=VAR_055748;Note=S->N;Dbxref=dbSNP:rs17160151
FBN3	Q75N90	2293	2362	2314	2314	Natural variant	ID=VAR_055748;Note=S->N;Dbxref=dbSNP:rs17160151
FBN3	Q75N90	2293	2362	2314	2314	Natural variant	ID=VAR_055748;Note=S->N;Dbxref=dbSNP:rs17160151
EFEMP2	O95967	163	202	26	443	Chain	ID=PRO_0000007575;Note=EGF-containing fibulin-like extracellular matrix protein 2
EFEMP2	O95967	122	163	26	443	Chain	ID=PRO_0000007575;Note=EGF-containing fibulin-like extracellular matrix protein 2
EFEMP2	O95967	53	122	26	443	Chain	ID=PRO_0000007575;Note=EGF-containing fibulin-like extracellular matrix protein 2
EFEMP2	O95967	53	122	36	81	Domain	Note=EGF-like 1%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	163	202	123	163	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	122	163	123	163	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	163	202	164	202	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	163	202	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EFEMP2	O95967	53	122	58	121	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|Ref.11
EFEMP2	O95967	53	122	65	80	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|Ref.11
EFEMP2	O95967	53	122	71	109	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|Ref.11
EFEMP2	O95967	122	163	127	140	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	122	163	134	149	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	122	163	151	162	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	163	202	168	177	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	163	202	173	186	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	163	202	188	201	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP2	O95967	53	122	57	57	Natural variant	ID=VAR_027019;Note=In ARCL1B. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16685658;Dbxref=dbSNP:rs119489101,PMID:16685658
EFEMP2	O95967	53	122	96	96	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFEMP2	O95967	53	122	103	111	Sequence conflict	Note=AQHPNPCPP->VNTQPLPT;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFEMP2	O95967	53	122	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KL7
EFEMP2	O95967	53	122	78	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KL7
EFEMP2	O95967	53	122	113	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KL7
BTRC	Q9Y297	52	78	1	605	Chain	ID=PRO_0000050980;Note=F-box/WD repeat-containing protein 1A
BTRC	Q9Y297	78	108	1	605	Chain	ID=PRO_0000050980;Note=F-box/WD repeat-containing protein 1A
BTRC	Q9Y297	52	78	17	52	Alternative sequence	ID=VSP_006764;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10531035,ECO:0000303|PubMed:9660940;Dbxref=PMID:10531035,PMID:9660940
FBXO5	Q9UKT4	303	364	1	447	Chain	ID=PRO_0000119881;Note=F-box only protein 5
FBXO5	Q9UKT4	303	364	261	409	Region	Note=Requires for efficient binding to CDC20;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TSG3
FBXO5	Q9UKT4	303	364	261	339	Region	Note=Sufficient for interaction with RPS6KA2%3B Prevents association of CDC20 with RPS6KA2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TSG3
FBXO5	Q9UKT4	303	364	305	447	Region	Note=Inhibits APC ubiquitin ligase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO5	Q9UKT4	303	364	322	325	Region	Note=Competitively blocks access of APC substrates to the D-box coreceptor formed by FZR1 and ANAPC10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708001;Dbxref=PMID:23708001
FBXO5	Q9UKT4	303	364	322	325	Mutagenesis	Note=Does not affect inhibition of UBE2S-catalyzed chain elongation. Efficiently inhibits the degradation of PTTG1 at relatively high concentration. Reduces the competitive ability of FBXO5 to inhibit the association of PTTG1 to APC. Can not compete with the APC substrate for APC binding. Decreases inhibition of CCNB1 ubiquitination by UBE2C. RTPL->ATPA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23708001,ECO:0000269|PubMed:23708605;Dbxref=PMID:23708001,PMID:23708605
FBXO5	Q9UKT4	303	364	339	345	Mutagenesis	Note=Impairs CCNB1 ubiquitination by UBE2C%3B when associated with 356-Y--R-358 del. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO5	Q9UKT4	303	364	345	345	Mutagenesis	Note=Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C%3B when associated with 346-S--T-355 del. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO5	Q9UKT4	303	364	346	355	Mutagenesis	Note=Inhibits CCNB1 ubiquitination by UBE2C. Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C%3B when associated with A-345%3B A-356 and A-358. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO5	Q9UKT4	303	364	356	358	Mutagenesis	Note=Impairs CCNB1 ubiquitination by UBE2C%3B when associated with 339-K--L-345 del. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO5	Q9UKT4	303	364	356	356	Mutagenesis	Note=Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C%3B when associated with 346-S--T-355 del. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO5	Q9UKT4	303	364	358	358	Mutagenesis	Note=Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C%3B when associated with 346-S--T-355 del. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708605;Dbxref=PMID:23708605
FBXO15	Q8NCQ5	192	261	1	510	Chain	ID=PRO_0000119893;Note=F-box only protein 15
FBXO6	Q9NRD1	138	169	1	293	Chain	ID=PRO_0000119882;Note=F-box only protein 6
FBXO6	Q9NRD1	138	169	78	259	Domain	Note=FBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00482
FBXO6	Q9NRD1	138	169	139	139	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXO6	Q9NRD1	138	169	143	144	Sequence conflict	Note=SQ->WE;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXO6	Q9NRD1	138	169	149	152	Sequence conflict	Note=VAEG->LADR;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXO22	Q8NEZ5	122	154	1	403	Chain	ID=PRO_0000119906;Note=F-box only protein 22
FBXO22	Q8NEZ5	154	209	1	403	Chain	ID=PRO_0000119906;Note=F-box only protein 22
FBXO22	Q8NEZ5	122	154	128	128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FBXO22	Q8NEZ5	154	209	194	194	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FBXO22	Q8NEZ5	122	154	47	403	Alternative sequence	ID=VSP_041821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBXO22	Q8NEZ5	154	209	47	403	Alternative sequence	ID=VSP_041821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCRL6	Q6DN72	106	201	20	434	Chain	ID=PRO_0000280213;Note=Fc receptor-like protein 6
FCRL6	Q6DN72	201	295	20	434	Chain	ID=PRO_0000280213;Note=Fc receptor-like protein 6
FCRL6	Q6DN72	336	358	20	434	Chain	ID=PRO_0000280213;Note=Fc receptor-like protein 6
FCRL6	Q6DN72	106	201	20	307	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL6	Q6DN72	201	295	20	307	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL6	Q6DN72	336	358	329	434	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL6	Q6DN72	106	201	111	197	Domain	Note=Ig-like C2-type 2
FCRL6	Q6DN72	201	295	207	293	Domain	Note=Ig-like C2-type 3
FCRL6	Q6DN72	201	295	273	273	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL6	Q6DN72	106	201	132	180	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL6	Q6DN72	201	295	228	276	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL6	Q6DN72	106	201	105	199	Alternative sequence	ID=VSP_023566;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
FCRL6	Q6DN72	336	358	356	356	Mutagenesis	Note=No change of phosphorylation implicated in interaction with PTPN11. Loss of interaction with INPPD5%2C INPPL1 and GRB2. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17213291,ECO:0000269|PubMed:20933011;Dbxref=PMID:17213291,PMID:20933011
FCRL6	Q6DN72	106	201	114	114	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCRL6	Q6DN72	106	201	123	123	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCRL6	Q6DN72	201	295	250	250	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCHSD1	Q86WN1	480	508	1	690	Chain	ID=PRO_0000278212;Note=F-BAR and double SH3 domains protein 1
FCHSD1	Q86WN1	383	437	1	690	Chain	ID=PRO_0000278212;Note=F-BAR and double SH3 domains protein 1
FCHSD1	Q86WN1	308	348	1	690	Chain	ID=PRO_0000278212;Note=F-BAR and double SH3 domains protein 1
FCHSD1	Q86WN1	276	308	1	690	Chain	ID=PRO_0000278212;Note=F-BAR and double SH3 domains protein 1
FCHSD1	Q86WN1	192	235	1	690	Chain	ID=PRO_0000278212;Note=F-BAR and double SH3 domains protein 1
FCHSD1	Q86WN1	276	308	12	282	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHSD1	Q86WN1	192	235	12	282	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHSD1	Q86WN1	480	508	468	529	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FCHSD1	Q86WN1	383	437	354	384	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FCHSD1	Q86WN1	308	348	1	320	Alternative sequence	ID=VSP_023160;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
FCHSD1	Q86WN1	276	308	1	320	Alternative sequence	ID=VSP_023160;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
FCHSD1	Q86WN1	192	235	1	320	Alternative sequence	ID=VSP_023160;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
FCHSD1	Q86WN1	308	348	321	348	Alternative sequence	ID=VSP_023163;Note=In isoform 2. GKSGLEKEVQRLTSRAARDYKIQNHGHR->MQLAKYQSHSKSCPTVFPPTPVLCLPNQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
FCHSD1	Q86WN1	480	508	481	485	Alternative sequence	ID=VSP_023164;Note=In isoform 3. AGRED->GVRMS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCHSD1	Q86WN1	480	508	486	690	Alternative sequence	ID=VSP_023165;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCHSD1	Q86WN1	308	348	344	344	Natural variant	ID=VAR_030692;Note=N->K;Dbxref=dbSNP:rs3749760
FCGR1A	P12314	17	102	16	374	Chain	ID=PRO_0000015139;Note=High affinity immunoglobulin gamma Fc receptor I
FCGR1A	P12314	17	102	16	292	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR1A	P12314	17	102	22	101	Domain	Note=Ig-like C2-type 1
FCGR1A	P12314	17	102	95	184	Domain	Note=Ig-like C2-type 2
FCGR1A	P12314	17	102	59	59	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667
FCGR1A	P12314	17	102	78	78	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:21965667;Dbxref=PMID:19159218,PMID:21965667
FCGR1A	P12314	17	102	43	85	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667
FCGR1A	P12314	17	102	25	25	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGR1A	P12314	17	102	23	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	31	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	39	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	54	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	67	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	77	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
FCGR1A	P12314	17	102	88	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X4M
FCGR1A	P12314	17	102	96	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O
HAP1	P54257	425	477	1	671	Chain	ID=PRO_0000083894;Note=Huntingtin-associated protein 1
HAP1	P54257	425	477	106	461	Domain	Note=HAP1 N-terminal
HAP1	P54257	425	477	212	427	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HAP1	P54257	425	477	261	601	Compositional bias	Note=Glu-rich
HAP1	P54257	425	477	401	477	Alternative sequence	ID=VSP_004277;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.5;Dbxref=PMID:14702039
HAP1	P54257	425	477	426	477	Alternative sequence	ID=VSP_004278;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7477378,ECO:0000303|PubMed:9668110;Dbxref=PMID:7477378,PMID:9668110
HAP1	P54257	425	477	437	437	Natural variant	ID=VAR_046739;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18192679;Dbxref=dbSNP:rs11867808,PMID:18192679
FERMT2	Q96AC1	321	366	1	680	Chain	ID=PRO_0000219456;Note=Fermitin family homolog 2
FERMT2	Q96AC1	130	175	1	680	Chain	ID=PRO_0000219456;Note=Fermitin family homolog 2
FERMT2	Q96AC1	52	130	1	680	Chain	ID=PRO_0000219456;Note=Fermitin family homolog 2
FERMT2	Q96AC1	321	366	1	680	Chain	ID=PRO_0000219456;Note=Fermitin family homolog 2
FERMT2	Q96AC1	130	175	1	680	Chain	ID=PRO_0000219456;Note=Fermitin family homolog 2
FERMT2	Q96AC1	52	130	1	680	Chain	ID=PRO_0000219456;Note=Fermitin family homolog 2
FERMT2	Q96AC1	321	366	189	661	Domain	Note=FERM
FERMT2	Q96AC1	321	366	189	661	Domain	Note=FERM
FERMT2	Q96AC1	52	130	40	81	Region	Note=Interaction with membranes containing phosphatidylinositol phosphate
FERMT2	Q96AC1	52	130	40	81	Region	Note=Interaction with membranes containing phosphatidylinositol phosphate
FERMT2	Q96AC1	130	175	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
FERMT2	Q96AC1	130	175	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
FERMT2	Q96AC1	321	366	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
FERMT2	Q96AC1	321	366	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
FERMT2	Q96AC1	321	366	351	351	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569
FERMT2	Q96AC1	321	366	351	351	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569
FERMT2	Q96AC1	52	130	74	81	Mutagenesis	Note=Abolishes lipid-binding via the N-terminus%3B when associated with A-40. KTHWTLDK->ATAATLDA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22078565;Dbxref=PMID:22078565
FERMT2	Q96AC1	52	130	74	81	Mutagenesis	Note=Abolishes lipid-binding via the N-terminus%3B when associated with A-40. KTHWTLDK->ATAATLDA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22078565;Dbxref=PMID:22078565
FERMT2	Q96AC1	52	130	58	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LGX
FERMT2	Q96AC1	52	130	58	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LGX
FERMT2	Q96AC1	52	130	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LGX
FERMT2	Q96AC1	52	130	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LGX
FERMT2	Q96AC1	52	130	79	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LGX
FERMT2	Q96AC1	52	130	79	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LGX
FERMT2	Q96AC1	321	366	347	353	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MSU
FERMT2	Q96AC1	321	366	347	353	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MSU
FERMT2	Q96AC1	321	366	354	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MSU
FERMT2	Q96AC1	321	366	354	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MSU
FER	P16591	69	127	1	822	Chain	ID=PRO_0000088084;Note=Tyrosine-protein kinase Fer
FER	P16591	222	267	1	822	Chain	ID=PRO_0000088084;Note=Tyrosine-protein kinase Fer
FER	P16591	443	511	1	822	Chain	ID=PRO_0000088084;Note=Tyrosine-protein kinase Fer
FER	P16591	69	127	1	259	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FER	P16591	222	267	1	259	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FER	P16591	443	511	460	550	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
FER	P16591	69	127	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
FER	P16591	222	267	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
FER	P16591	69	127	123	185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FER	P16591	69	127	1	369	Alternative sequence	ID=VSP_043846;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22223638;Dbxref=PMID:22223638
FER	P16591	222	267	1	369	Alternative sequence	ID=VSP_043846;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22223638;Dbxref=PMID:22223638
FER	P16591	69	127	1	175	Alternative sequence	ID=VSP_041765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FER	P16591	443	511	443	443	Natural variant	ID=VAR_041694;Note=A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34259824,PMID:17344846
FER	P16591	443	511	460	460	Natural variant	ID=VAR_041695;Note=In a lung small cell carcinoma sample%3B somatic mutation. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
FER	P16591	443	511	507	507	Natural variant	ID=VAR_051695;Note=I->T;Dbxref=dbSNP:rs34204308
FER	P16591	443	511	483	483	Mutagenesis	Note=Abolishes kinase activity. Abolishes location at microtubules. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12972546;Dbxref=PMID:12972546
FER	P16591	222	267	234	234	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
FER	P16591	443	511	447	447	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FER	P16591	443	511	485	485	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FER	P16591	443	511	492	492	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
FER	P16591	443	511	505	505	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FER	P16591	443	511	455	457	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KK6
FER	P16591	443	511	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KK6
FER	P16591	443	511	467	472	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KK6
FER	P16591	443	511	480	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KK6
FER	P16591	443	511	492	498	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KK6
FER	P16591	443	511	501	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KK6
FETUB	Q9UGM5	75	112	16	382	Chain	ID=PRO_0000008899;Note=Fetuin-B
FETUB	Q9UGM5	75	112	16	382	Chain	ID=PRO_0000008899;Note=Fetuin-B
FETUB	Q9UGM5	75	112	25	138	Domain	Note=Cystatin fetuin-B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00862
FETUB	Q9UGM5	75	112	25	138	Domain	Note=Cystatin fetuin-B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00862
FETUB	Q9UGM5	75	112	93	104	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00862
FETUB	Q9UGM5	75	112	93	104	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00862
FETUB	Q9UGM5	75	112	76	112	Alternative sequence	ID=VSP_047135;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15499407;Dbxref=PMID:15499407
FETUB	Q9UGM5	75	112	76	112	Alternative sequence	ID=VSP_047135;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15499407;Dbxref=PMID:15499407
FGGY	Q96C11	223	266	1	551	Chain	ID=PRO_0000326452;Note=FGGY carbohydrate kinase domain-containing protein
FGGY	Q96C11	301	337	1	551	Chain	ID=PRO_0000326452;Note=FGGY carbohydrate kinase domain-containing protein
FGGY	Q96C11	223	266	1	299	Alternative sequence	ID=VSP_054533;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FGGY	Q96C11	223	266	246	246	Natural variant	ID=VAR_059194;Note=L->V;Dbxref=dbSNP:rs11207463
FHDC1	Q9C0D6	406	461	1	1143	Chain	ID=PRO_0000317280;Note=FH2 domain-containing protein 1
FHDC1	Q9C0D6	406	461	1	1143	Chain	ID=PRO_0000317280;Note=FH2 domain-containing protein 1
FHDC1	Q9C0D6	406	461	87	482	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
FHDC1	Q9C0D6	406	461	87	482	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
ZFPM1	Q8IX07	48	89	1	1006	Chain	ID=PRO_0000221041;Note=Zinc finger protein ZFPM1
ZFPM1	Q8IX07	315	347	1	1006	Chain	ID=PRO_0000221041;Note=Zinc finger protein ZFPM1
ZFPM1	Q8IX07	315	347	320	342	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFPM1	Q8IX07	315	347	330	341	Region	Note=Interaction with TACC3;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZFPM1	Q8IX07	48	89	84	84	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZFPM1	Q8IX07	48	89	70	70	Natural variant	ID=VAR_057491;Note=G->A;Dbxref=dbSNP:rs34916016
FNDC7	Q5VTL7	713	723	26	733	Chain	ID=PRO_0000328880;Note=Fibronectin type III domain-containing protein 7
FNDC7	Q5VTL7	713	723	631	715	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HDAC10	Q969S8	252	272	1	669	Chain	ID=PRO_0000114712;Note=Histone deacetylase 10
HDAC10	Q969S8	252	272	1	323	Region	Note=Histone deacetylase
HDAC10	Q969S8	252	272	252	301	Alternative sequence	ID=VSP_014698;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
HDAC10	Q969S8	252	272	252	271	Alternative sequence	ID=VSP_002089;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11739383;Dbxref=PMID:11739383
HDAC11	Q96DB2	84	123	1	347	Chain	ID=PRO_0000114715;Note=Histone deacetylase 11
HDAC11	Q96DB2	84	123	14	326	Region	Note=Histone deacetylase
HDAC11	Q96DB2	84	123	85	107	Alternative sequence	ID=VSP_043083;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HDAC11	Q96DB2	84	123	113	113	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
HDAC4	P56524	755	791	1	1084	Chain	ID=PRO_0000114699;Note=Histone deacetylase 4
HDAC4	P56524	244	288	1	1084	Chain	ID=PRO_0000114699;Note=Histone deacetylase 4
HDAC4	P56524	7	31	1	1084	Chain	ID=PRO_0000114699;Note=Histone deacetylase 4
HDAC4	P56524	244	288	118	313	Region	Note=Interaction with MEF2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10487761;Dbxref=PMID:10487761
HDAC4	P56524	755	791	655	1084	Region	Note=Histone deacetylase
HDAC4	P56524	244	288	246	246	Modified residue	Note=Phosphoserine%3B by CaMK4 and SIK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958686;Dbxref=PMID:10958686
HDAC4	P56524	7	31	1	117	Alternative sequence	ID=VSP_057290;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HDAC4	P56524	244	288	246	246	Mutagenesis	Note=Reduces phosphorylation and its subsequent nuclear export. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958686;Dbxref=PMID:10958686
HDAC4	P56524	755	791	754	756	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VQM
HDAC4	P56524	755	791	762	786	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VQM
HDAC4	P56524	755	791	789	795	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VQM
FOXN3	O00409	248	270	1	490	Chain	ID=PRO_0000091869;Note=Forkhead box protein N3
FOXN3	O00409	248	270	1	490	Chain	ID=PRO_0000091869;Note=Forkhead box protein N3
FOXN3	O00409	248	270	249	271	Alternative sequence	ID=VSP_001551;Note=In isoform 2. DPDIDAASAMMLLNTPPEIQAGF->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXN3	O00409	248	270	249	271	Alternative sequence	ID=VSP_001551;Note=In isoform 2. DPDIDAASAMMLLNTPPEIQAGF->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXP3	Q9BZS1	245	272	1	431	Chain	ID=PRO_0000091886;Note=Forkhead box protein P3
FOXP3	Q9BZS1	70	105	1	431	Chain	ID=PRO_0000091886;Note=Forkhead box protein P3
FOXP3	Q9BZS1	245	272	1	417	Chain	ID=PRO_0000432430;Note=Forkhead box protein P3%2C C-terminally processed;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830
FOXP3	Q9BZS1	70	105	1	417	Chain	ID=PRO_0000432430;Note=Forkhead box protein P3%2C C-terminally processed;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830
FOXP3	Q9BZS1	245	272	52	417	Chain	ID=PRO_0000432431;Note=Forkhead box protein P3 41 kDa form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830
FOXP3	Q9BZS1	70	105	52	417	Chain	ID=PRO_0000432431;Note=Forkhead box protein P3 41 kDa form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19117830;Dbxref=PMID:19117830
FOXP3	Q9BZS1	245	272	239	260	Region	Note=Leucine-zipper
FOXP3	Q9BZS1	70	105	68	76	Motif	Note=Nuclear export signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
FOXP3	Q9BZS1	70	105	92	96	Motif	Note=LXXLL motif;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18354202;Dbxref=PMID:18354202
FOXP3	Q9BZS1	245	272	239	248	Motif	Note=Nuclear export signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
FOXP3	Q9BZS1	245	272	263	263	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22312127;Dbxref=PMID:22312127
FOXP3	Q9BZS1	245	272	268	268	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22312127;Dbxref=PMID:22312127
FOXP3	Q9BZS1	245	272	250	250	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6
FOXP3	Q9BZS1	245	272	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6
FOXP3	Q9BZS1	245	272	263	263	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6
FOXP3	Q9BZS1	245	272	268	268	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99JB6
FOXP3	Q9BZS1	70	105	72	106	Alternative sequence	ID=VSP_015796;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4,ECO:0000303|Ref.7;Dbxref=PMID:15489334
FOXP3	Q9BZS1	245	272	246	272	Alternative sequence	ID=VSP_047859;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
FOXP3	Q9BZS1	245	272	251	251	Natural variant	ID=VAR_011330;Note=In IPEX%3B significantly reduces dimerization. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11120765,ECO:0000269|PubMed:21458306;Dbxref=PMID:11120765,PMID:21458306
FOXP3	Q9BZS1	70	105	71	71	Mutagenesis	Note=Decrease in nuclear export%3B when associated with A-69%2C A-74 and A-76. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
FOXP3	Q9BZS1	70	105	74	74	Mutagenesis	Note=Decrease in nuclear export%3B when associated with A-69%2C A-71 and A-76. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
FOXP3	Q9BZS1	70	105	76	76	Mutagenesis	Note=Decrease in nuclear export%3B when associated with A-69%2C A-71 and A-74. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
FOXP3	Q9BZS1	70	105	95	96	Mutagenesis	Note=Loss of interaction with RORA. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18354202;Dbxref=PMID:18354202
FOXP3	Q9BZS1	245	272	246	246	Mutagenesis	Note=Decrease in nuclear export%3B when associated with A-242 and A-248. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
FOXP3	Q9BZS1	245	272	248	248	Mutagenesis	Note=Decrease in nuclear export%3B when associated with A-242 and A-246. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22678915;Dbxref=PMID:22678915
HECW1	Q76N89	799	833	1	1606	Chain	ID=PRO_0000277665;Note=E3 ubiquitin-protein ligase HECW1
HECW1	Q76N89	1033	1078	1	1606	Chain	ID=PRO_0000277665;Note=E3 ubiquitin-protein ligase HECW1
HECW1	Q76N89	799	833	829	862	Domain	Note=WW 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
HECW1	Q76N89	1033	1078	1018	1051	Domain	Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
HECW1	Q76N89	799	833	800	834	Alternative sequence	ID=VSP_054642;Note=In isoform 2. GECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HECW1	Q76N89	1033	1078	1034	1038	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4H
HECW1	Q76N89	1033	1078	1039	1042	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4H
HECW1	Q76N89	1033	1078	1043	1047	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4H
FREM1	Q5H8C1	1802	1852	22	2179	Chain	ID=PRO_0000010122;Note=FRAS1-related extracellular matrix protein 1
FREM1	Q5H8C1	1029	1091	22	2179	Chain	ID=PRO_0000010122;Note=FRAS1-related extracellular matrix protein 1
FREM1	Q5H8C1	1802	1852	22	2179	Chain	ID=PRO_0000010122;Note=FRAS1-related extracellular matrix protein 1
FREM1	Q5H8C1	1029	1091	22	2179	Chain	ID=PRO_0000010122;Note=FRAS1-related extracellular matrix protein 1
FREM1	Q5H8C1	1029	1091	1024	1126	Repeat	Note=CSPG 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01201
FREM1	Q5H8C1	1029	1091	1024	1126	Repeat	Note=CSPG 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01201
FREM1	Q5H8C1	1802	1852	1731	1830	Domain	Note=Calx-beta
FREM1	Q5H8C1	1802	1852	1731	1830	Domain	Note=Calx-beta
FREM1	Q5H8C1	1802	1852	1	1803	Alternative sequence	ID=VSP_015025;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FREM1	Q5H8C1	1029	1091	1	1803	Alternative sequence	ID=VSP_015025;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FREM1	Q5H8C1	1802	1852	1	1803	Alternative sequence	ID=VSP_015025;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FREM1	Q5H8C1	1029	1091	1	1803	Alternative sequence	ID=VSP_015025;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FREM1	Q5H8C1	1029	1091	1	1587	Alternative sequence	ID=VSP_015026;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FREM1	Q5H8C1	1029	1091	1	1587	Alternative sequence	ID=VSP_015026;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FREM1	Q5H8C1	1029	1091	1	1464	Alternative sequence	ID=VSP_047283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FREM1	Q5H8C1	1029	1091	1	1464	Alternative sequence	ID=VSP_047283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FREM1	Q5H8C1	1802	1852	1804	1809	Alternative sequence	ID=VSP_015030;Note=In isoform 4. MSTKMW->SSILCL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FREM1	Q5H8C1	1802	1852	1804	1809	Alternative sequence	ID=VSP_015030;Note=In isoform 4. MSTKMW->SSILCL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FREM1	Q5H8C1	1802	1852	1810	2179	Alternative sequence	ID=VSP_015031;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FREM1	Q5H8C1	1802	1852	1810	2179	Alternative sequence	ID=VSP_015031;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FRMD1	Q8N878	268	290	1	549	Chain	ID=PRO_0000247364;Note=FERM domain-containing protein 1
FRMD1	Q8N878	268	290	54	369	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD1	Q8N878	268	290	274	274	Natural variant	ID=VAR_027099;Note=R->C;Dbxref=dbSNP:rs902393
FRMD6	Q96NE9	186	238	1	622	Chain	ID=PRO_0000219448;Note=FERM domain-containing protein 6
FRMD6	Q96NE9	186	238	16	328	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD6	Q96NE9	186	238	1	358	Alternative sequence	ID=VSP_008022;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCRL4	Q96PJ5	102	187	20	515	Chain	ID=PRO_0000331642;Note=Fc receptor-like protein 4
FCRL4	Q96PJ5	102	187	20	387	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL4	Q96PJ5	102	187	102	183	Domain	Note=Ig-like C2-type 2
FCRL4	Q96PJ5	102	187	123	167	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL4	Q96PJ5	102	187	179	179	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBXL2	Q9UKC9	298	317	1	423	Chain	ID=PRO_0000119840;Note=F-box/LRR-repeat protein 2
FBXL2	Q9UKC9	298	317	296	321	Repeat	Note=LRR 10
HAO1	Q9UJM8	271	324	1	370	Chain	ID=PRO_0000206318;Note=Hydroxyacid oxidase 1
HAO1	Q9UJM8	271	324	1	365	Domain	Note=FMN hydroxy acid dehydrogenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00683
HAO1	Q9UJM8	271	324	291	315	Nucleotide binding	Note=FMN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00683
HAO1	Q9UJM8	271	324	291	295	Nucleotide binding	Note=FMN binding;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00683,ECO:0000269|PubMed:18215067,ECO:0000269|PubMed:20054120,ECO:0000269|Ref.10;Dbxref=PMID:18215067,PMID:20054120
HAO1	Q9UJM8	271	324	315	315	Binding site	Note=FMN;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00683,ECO:0000269|PubMed:18215067,ECO:0000269|PubMed:20054120,ECO:0000269|Ref.10;Dbxref=PMID:18215067,PMID:20054120
HAO1	Q9UJM8	271	324	271	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZL
HAO1	Q9UJM8	271	324	285	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZL
HAO1	Q9UJM8	271	324	297	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZL
HAO1	Q9UJM8	271	324	309	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZL
HAO1	Q9UJM8	271	324	315	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZL
FCGRT	P55899	24	108	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	108	200	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	200	290	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	290	329	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	24	108	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	108	200	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	200	290	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	290	329	24	365	Chain	ID=PRO_0000015157;Note=IgG receptor FcRn large subunit p51;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
FCGRT	P55899	24	108	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	108	200	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	200	290	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	290	329	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	24	108	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	108	200	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	200	290	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	290	329	24	297	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	290	329	298	321	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	290	329	298	321	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	290	329	322	365	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	290	329	322	365	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	200	290	202	289	Domain	Note=Ig-like C1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCGRT	P55899	200	290	202	289	Domain	Note=Ig-like C1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCGRT	P55899	24	108	24	110	Region	Note=Alpha-1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	108	200	24	110	Region	Note=Alpha-1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	24	108	24	110	Region	Note=Alpha-1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	108	200	24	110	Region	Note=Alpha-1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	108	200	111	200	Region	Note=Alpha-2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	200	290	111	200	Region	Note=Alpha-2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	108	200	111	200	Region	Note=Alpha-2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	200	290	111	200	Region	Note=Alpha-2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	200	290	201	290	Region	Note=Alpha-3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	290	329	201	290	Region	Note=Alpha-3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	200	290	201	290	Region	Note=Alpha-3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	290	329	201	290	Region	Note=Alpha-3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	290	329	291	297	Region	Note=Connecting peptide
FCGRT	P55899	290	329	291	297	Region	Note=Connecting peptide
FCGRT	P55899	108	200	125	125	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	108	200	125	125	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGRT	P55899	108	200	119	182	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	108	200	119	182	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	200	290	221	275	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	200	290	221	275	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EXU,ECO:0000269|PubMed:10933786;Dbxref=PMID:10933786
FCGRT	P55899	24	108	101	103	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGRT	P55899	24	108	101	103	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGRT	P55899	200	290	201	201	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGRT	P55899	200	290	201	201	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGRT	P55899	24	108	29	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	29	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	46	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	46	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	56	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	56	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	72	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	72	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	83	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	83	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	24	108	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0F
FCGRT	P55899	108	200	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0F
FCGRT	P55899	24	108	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0F
FCGRT	P55899	108	200	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0F
FCGRT	P55899	108	200	112	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	112	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	127	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	127	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	138	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	138	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	145	148	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	145	148	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	155	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	155	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	170	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	170	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	181	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	181	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	194	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	108	200	194	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	204	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	204	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	213	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M1B
FCGRT	P55899	200	290	213	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M1B
FCGRT	P55899	200	290	216	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	216	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	231	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	231	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	240	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	240	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	246	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	246	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	253	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M1B
FCGRT	P55899	200	290	253	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M1B
FCGRT	P55899	200	290	257	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	257	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	267	269	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BJT
FCGRT	P55899	200	290	267	269	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BJT
FCGRT	P55899	200	290	270	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	270	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	273	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	273	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	282	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C97
FCGRT	P55899	200	290	282	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C97
FCGRT	P55899	200	290	286	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FCGRT	P55899	200	290	286	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C98
FGR	P09769	110	142	2	529	Chain	ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr
FGR	P09769	110	142	2	529	Chain	ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr
FGR	P09769	110	142	2	529	Chain	ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr
FGR	P09769	110	142	77	138	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FGR	P09769	110	142	77	138	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FGR	P09769	110	142	77	138	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FGR	P09769	110	142	110	110	Natural variant	ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846
FGR	P09769	110	142	110	110	Natural variant	ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846
FGR	P09769	110	142	110	110	Natural variant	ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846
FGR	P09769	110	142	130	130	Natural variant	ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846
FGR	P09769	110	142	130	130	Natural variant	ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846
FGR	P09769	110	142	130	130	Natural variant	ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846
FGF12	P61328	66	103	1	243	Chain	ID=PRO_0000147604;Note=Fibroblast growth factor 12
FGF12	P61328	66	103	1	66	Alternative sequence	ID=VSP_010222;Note=In isoform 2. MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRP->MESK;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10049777,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10049777,PMID:14702039,PMID:15489334
FGF12	P61328	66	103	73	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1U
FGF12	P61328	66	103	80	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1U
FGF12	P61328	66	103	83	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1U
FGF12	P61328	66	103	93	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1U
FGF12	P61328	66	103	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1U
FIG4	Q92562	215	258	1	907	Chain	ID=PRO_0000209743;Note=Polyphosphoinositide phosphatase
FIG4	Q92562	820	848	1	907	Chain	ID=PRO_0000209743;Note=Polyphosphoinositide phosphatase
FIG4	Q92562	215	258	154	547	Domain	Note=SAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00183
FKBP15	Q5T1M5	886	922	1	1219	Chain	ID=PRO_0000299556;Note=FK506-binding protein 15
FKBP15	Q5T1M5	355	391	1	1219	Chain	ID=PRO_0000299556;Note=FK506-binding protein 15
FKBP15	Q5T1M5	239	288	1	1219	Chain	ID=PRO_0000299556;Note=FK506-binding protein 15
FKBP15	Q5T1M5	108	133	1	1219	Chain	ID=PRO_0000299556;Note=FK506-binding protein 15
FKBP15	Q5T1M5	239	288	197	290	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP15	Q5T1M5	108	133	72	169	Region	Note=Important for function in growth cone organization;Ontology_term=ECO:0000250;evidence=ECO:0000250
FKBP15	Q5T1M5	355	391	356	356	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
FKBP15	Q5T1M5	886	922	473	1219	Alternative sequence	ID=VSP_027757;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FKBP1A	P62942	12	28	2	108	Chain	ID=PRO_0000075289;Note=Peptidyl-prolyl cis-trans isomerase FKBP1A
FKBP1A	P62942	12	28	2	108	Chain	ID=PRO_0000075289;Note=Peptidyl-prolyl cis-trans isomerase FKBP1A
FKBP1A	P62942	12	28	20	108	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP1A	P62942	12	28	20	108	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP1A	P62942	12	28	22	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPN
FKBP1A	P62942	12	28	22	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PPN
FKBP5	Q13451	342	422	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	280	342	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	252	280	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	342	422	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	280	342	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	252	280	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	342	422	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	280	342	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	252	280	1	457	Chain	ID=PRO_0000075324;Note=Peptidyl-prolyl cis-trans isomerase FKBP5
FKBP5	Q13451	280	342	268	301	Repeat	Note=TPR 1
FKBP5	Q13451	252	280	268	301	Repeat	Note=TPR 1
FKBP5	Q13451	280	342	268	301	Repeat	Note=TPR 1
FKBP5	Q13451	252	280	268	301	Repeat	Note=TPR 1
FKBP5	Q13451	280	342	268	301	Repeat	Note=TPR 1
FKBP5	Q13451	252	280	268	301	Repeat	Note=TPR 1
FKBP5	Q13451	342	422	317	350	Repeat	Note=TPR 2
FKBP5	Q13451	280	342	317	350	Repeat	Note=TPR 2
FKBP5	Q13451	342	422	317	350	Repeat	Note=TPR 2
FKBP5	Q13451	280	342	317	350	Repeat	Note=TPR 2
FKBP5	Q13451	342	422	317	350	Repeat	Note=TPR 2
FKBP5	Q13451	280	342	317	350	Repeat	Note=TPR 2
FKBP5	Q13451	342	422	351	384	Repeat	Note=TPR 3
FKBP5	Q13451	342	422	351	384	Repeat	Note=TPR 3
FKBP5	Q13451	342	422	351	384	Repeat	Note=TPR 3
FKBP5	Q13451	252	280	223	268	Alternative sequence	ID=VSP_044820;Note=In isoform 2. YGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQA->PKNPGRWIPKKNWSRLPLSKRREPYTSRCVSPYAILSISKNLFKCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	252	280	223	268	Alternative sequence	ID=VSP_044820;Note=In isoform 2. YGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQA->PKNPGRWIPKKNWSRLPLSKRREPYTSRCVSPYAILSISKNLFKCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	252	280	223	268	Alternative sequence	ID=VSP_044820;Note=In isoform 2. YGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQA->PKNPGRWIPKKNWSRLPLSKRREPYTSRCVSPYAILSISKNLFKCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	342	422	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	280	342	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	252	280	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	342	422	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	280	342	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	252	280	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	342	422	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	280	342	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	252	280	269	457	Alternative sequence	ID=VSP_044821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
FKBP5	Q13451	252	280	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	252	280	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	252	280	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	261	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	252	280	261	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	261	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	252	280	261	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	261	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	252	280	261	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	284	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	284	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	284	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	306	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	306	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	306	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	333	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	333	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	333	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	333	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	333	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	280	342	333	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	351	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	351	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	351	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	367	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	367	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	367	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	385	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	385	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP5	Q13451	342	422	385	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OMP
FKBP8	Q14318	340	384	1	412	Chain	ID=PRO_0000075331;Note=Peptidyl-prolyl cis-trans isomerase FKBP8
FKBP8	Q14318	314	340	1	412	Chain	ID=PRO_0000075331;Note=Peptidyl-prolyl cis-trans isomerase FKBP8
FKBP8	Q14318	340	384	1	412	Chain	ID=PRO_0000075331;Note=Peptidyl-prolyl cis-trans isomerase FKBP8
FKBP8	Q14318	314	340	1	412	Chain	ID=PRO_0000075331;Note=Peptidyl-prolyl cis-trans isomerase FKBP8
FKBP8	Q14318	314	340	306	339	Repeat	Note=TPR 3
FKBP8	Q14318	314	340	306	339	Repeat	Note=TPR 3
FKBP8	Q14318	314	340	314	314	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	314	340	314	314	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	314	340	334	334	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	314	340	334	334	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	340	340	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	314	340	340	340	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	340	340	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	314	340	340	340	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	348	348	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	348	348	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	351	351	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	351	351	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	352	352	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	340	384	352	352	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
FKBP8	Q14318	314	340	306	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	314	340	306	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	314	340	322	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	314	340	322	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	340	384	340	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	314	340	340	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	340	384	340	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
FKBP8	Q14318	314	340	340	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGX
HCLS1	P14317	151	188	1	486	Chain	ID=PRO_0000083921;Note=Hematopoietic lineage cell-specific protein
HCLS1	P14317	151	188	116	152	Repeat	Note=Cortactin 2
HCLS1	P14317	151	188	153	189	Repeat	Note=Cortactin 3
HCLS1	P14317	151	188	134	209	Alternative sequence	ID=VSP_056429;Note=In isoform 2. SAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSA->ITLVALVAGTGWRRINGTKQLWDMTTRERRRNTSPREIMPRALVASMESRRTEWIRALSASMKWRPRPQLIRRRRP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FPGS	Q05932	46	89	43	587	Chain	ID=PRO_0000010097;Note=Folylpolyglutamate synthase%2C mitochondrial
FPGS	Q05932	89	107	43	587	Chain	ID=PRO_0000010097;Note=Folylpolyglutamate synthase%2C mitochondrial
FPGS	Q05932	167	193	43	587	Chain	ID=PRO_0000010097;Note=Folylpolyglutamate synthase%2C mitochondrial
FPGS	Q05932	89	107	106	109	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08192
FPGS	Q05932	46	89	43	50	Alternative sequence	ID=VSP_041959;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FPGS	Q05932	167	193	168	193	Alternative sequence	ID=VSP_041960;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FPGS	Q05932	89	107	101	101	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FNIP1	Q8TF40	207	235	1	1166	Chain	ID=PRO_0000308484;Note=Folliculin-interacting protein 1
FNIP1	Q8TF40	73	118	1	1166	Chain	ID=PRO_0000308484;Note=Folliculin-interacting protein 1
FNIP1	Q8TF40	207	235	37	478	Domain	Note=uDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180
FNIP1	Q8TF40	73	118	37	478	Domain	Note=uDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180
FNIP1	Q8TF40	73	118	96	99	Compositional bias	Note=Poly-Ser
FNIP1	Q8TF40	207	235	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
FNIP1	Q8TF40	207	235	208	235	Alternative sequence	ID=VSP_028984;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11853319;Dbxref=PMID:11853319
FNIP1	Q8TF40	73	118	76	76	Natural variant	ID=VAR_036824;Note=G->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17028174;Dbxref=dbSNP:rs7730228,PMID:15489334,PMID:17028174
HDAC1	Q13547	93	118	1	482	Chain	ID=PRO_0000114687;Note=Histone deacetylase 1
HDAC1	Q13547	212	243	1	482	Chain	ID=PRO_0000114687;Note=Histone deacetylase 1
HDAC1	Q13547	93	118	9	321	Region	Note=Histone deacetylase
HDAC1	Q13547	212	243	9	321	Region	Note=Histone deacetylase
HDAC1	Q13547	212	243	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HDAC1	Q13547	93	118	88	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
HDAC1	Q13547	93	118	97	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
HDAC1	Q13547	93	118	106	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
HDAC1	Q13547	212	243	217	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
HDAC1	Q13547	212	243	223	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
HDAC1	Q13547	212	243	234	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX
HDAC2	Q92769	213	244	1	488	Chain	ID=PRO_0000114693;Note=Histone deacetylase 2
HDAC2	Q92769	213	244	9	322	Region	Note=Histone deacetylase
HDAC2	Q92769	213	244	221	221	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13547
HDAC2	Q92769	213	244	230	230	Natural variant	ID=VAR_025311;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8917507;Dbxref=dbSNP:rs1042903,PMID:8917507
HDAC2	Q92769	213	244	218	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LY1
HDAC2	Q92769	213	244	224	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LY1
HDAC2	Q92769	213	244	235	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LY1
HDAC3	O15379	277	306	1	428	Chain	ID=PRO_0000114696;Note=Histone deacetylase 3
HDAC3	O15379	277	306	3	316	Region	Note=Histone deacetylase
HDAC3	O15379	277	306	273	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A69
HDAC3	O15379	277	306	290	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A69
HDAC3	O15379	277	306	300	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A69
FEZ2	Q9UHY8	125	164	1	353	Chain	ID=PRO_0000189528;Note=Fasciculation and elongation protein zeta-2
FEZ2	Q9UHY8	125	164	135	135	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
FEZ2	Q9UHY8	125	164	153	153	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000255;evidence=ECO:0000255
AHSG	P02765	191	225	19	300	Chain	ID=PRO_0000008887;Note=Alpha-2-HS-glycoprotein chain A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3944104;Dbxref=PMID:3944104
AHSG	P02765	225	253	19	300	Chain	ID=PRO_0000008887;Note=Alpha-2-HS-glycoprotein chain A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3944104;Dbxref=PMID:3944104
AHSG	P02765	191	225	144	255	Domain	Note=Cystatin fetuin-A-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00861
AHSG	P02765	225	253	144	255	Domain	Note=Cystatin fetuin-A-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00861
AHSG	P02765	191	225	32	358	Disulfide bond	Note=Interchain (between A and B chains)
AHSG	P02765	225	253	32	358	Disulfide bond	Note=Interchain (between A and B chains)
AHSG	P02765	191	225	208	219	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00861,ECO:0000269|PubMed:2760061;Dbxref=PMID:2760061
AHSG	P02765	225	253	230	247	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00861,ECO:0000269|PubMed:2760061;Dbxref=PMID:2760061
AHSG	P02765	225	253	248	248	Natural variant	ID=VAR_002388;Note=In allele AHSG*1. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9003486;Dbxref=dbSNP:rs4917,PMID:9003486
AHSG	P02765	191	225	204	204	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGD2	Q7Z6J4	442	486	1	655	Chain	ID=PRO_0000080942;Note=FYVE%2C RhoGEF and PH domain-containing protein 2
FGD2	Q7Z6J4	442	486	458	518	Zinc finger	Note=FYVE-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091
FGD2	Q7Z6J4	442	486	105	655	Alternative sequence	ID=VSP_038219;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
FGD2	Q7Z6J4	442	486	424	442	Alternative sequence	ID=VSP_013070;Note=In isoform 2. NETFKAAAQGPEGDIQEQE->MGGRRSPRAHSCPTPLNPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FGFR1OP2	Q9NVK5	132	170	1	253	Chain	ID=PRO_0000299041;Note=FGFR1 oncogene partner 2
FGFR1OP2	Q9NVK5	132	170	160	223	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFR1OP2	Q9NVK5	132	170	132	133	Site	Note=Breakpoint for translocation to form FGFR1OP2-FGFR1
FGFR1OP2	Q9NVK5	132	170	141	141	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FGFR1OP2	Q9NVK5	132	170	133	170	Alternative sequence	ID=VSP_027538;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:11042152,PMID:17974005
FGFRL1	Q8N441	26	117	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	117	144	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	26	117	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	117	144	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	26	117	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	117	144	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	26	117	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	117	144	25	504	Chain	ID=PRO_0000021250;Note=Fibroblast growth factor receptor-like 1
FGFRL1	Q8N441	26	117	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	117	144	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	117	144	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	117	144	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	117	144	25	378	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	29	115	Domain	Note=Ig-like C2-type 1
FGFRL1	Q8N441	26	117	29	115	Domain	Note=Ig-like C2-type 1
FGFRL1	Q8N441	26	117	29	115	Domain	Note=Ig-like C2-type 1
FGFRL1	Q8N441	26	117	29	115	Domain	Note=Ig-like C2-type 1
FGFRL1	Q8N441	26	117	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FGFRL1	Q8N441	26	117	51	99	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FGFRL1	Q8N441	26	117	51	99	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FGFRL1	Q8N441	26	117	51	99	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FGFRL1	Q8N441	26	117	51	99	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CFHR1	Q03591	143	202	19	330	Chain	ID=PRO_0000005896;Note=Complement factor H-related protein 1
CFHR1	Q03591	143	202	145	203	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR1	Q03591	143	202	194	194	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
CFHR1	Q03591	143	202	147	190	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR1	Q03591	143	202	176	201	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR1	Q03591	143	202	157	157	Natural variant	ID=VAR_001980;Note=H->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1711047,ECO:0000269|PubMed:1826708;Dbxref=dbSNP:rs425757,PMID:14702039,PMID:1711047,PMID:1826708
CFHR1	Q03591	143	202	159	159	Natural variant	ID=VAR_001981;Note=L->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1711047,ECO:0000269|PubMed:1826708;Dbxref=dbSNP:rs410232,PMID:14702039,PMID:1711047,PMID:1826708
CFHR1	Q03591	143	202	175	175	Natural variant	ID=VAR_001982;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1711047,ECO:0000269|PubMed:1826708;Dbxref=dbSNP:rs388862,PMID:14702039,PMID:1711047,PMID:1826708
CFHR3	Q02985	143	204	19	330	Chain	ID=PRO_0000005898;Note=Complement factor H-related protein 3
CFHR3	Q02985	204	265	19	330	Chain	ID=PRO_0000005898;Note=Complement factor H-related protein 3
CFHR3	Q02985	143	204	144	205	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	204	265	144	205	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	204	265	208	266	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	143	204	185	185	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CFHR3	Q02985	204	265	205	205	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CFHR3	Q02985	143	204	146	192	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	143	204	175	203	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	204	265	210	253	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	204	265	239	264	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR3	Q02985	143	204	144	204	Alternative sequence	ID=VSP_043041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CFHR3	Q02985	204	265	144	204	Alternative sequence	ID=VSP_043041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CFHR3	Q02985	143	204	143	143	Sequence conflict	Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFHR3	Q02985	143	204	194	194	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFHR3	Q02985	204	265	241	241	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFHR3	Q02985	204	265	260	260	Sequence conflict	Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FMO1	Q01740	44	107	2	532	Chain	ID=PRO_0000147639;Note=Dimethylaniline monooxygenase [N-oxide-forming] 1
FMO1	Q01740	44	107	2	532	Chain	ID=PRO_0000147639;Note=Dimethylaniline monooxygenase [N-oxide-forming] 1
FMO1	Q01740	44	107	60	61	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO1	Q01740	44	107	60	61	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO1	Q01740	44	107	61	62	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO1	Q01740	44	107	61	62	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO1	Q01740	44	107	45	107	Alternative sequence	ID=VSP_054543;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FMO1	Q01740	44	107	45	107	Alternative sequence	ID=VSP_054543;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FMO1	Q01740	44	107	97	97	Natural variant	ID=VAR_015358;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12527699;Dbxref=dbSNP:rs56841822,PMID:12527699
FMO1	Q01740	44	107	97	97	Natural variant	ID=VAR_015358;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12527699;Dbxref=dbSNP:rs56841822,PMID:12527699
HDGF	P51858	101	163	1	240	Chain	ID=PRO_0000191700;Note=Hepatoma-derived growth factor
HDGF	P51858	101	163	1	240	Chain	ID=PRO_0000191700;Note=Hepatoma-derived growth factor
HDGF	P51858	101	163	155	170	Motif	Note=Bipartite nuclear localization signal
HDGF	P51858	101	163	155	170	Motif	Note=Bipartite nuclear localization signal
HDGF	P51858	101	163	110	230	Compositional bias	Note=Glu-rich
HDGF	P51858	101	163	110	230	Compositional bias	Note=Glu-rich
HDGF	P51858	101	163	132	132	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16807684,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16807684,PMID:17081983,PMID:17487921,PMID:18088087,PMID:18318008,PMID:19367720,PMID:19690332,PMID:23186163,PMID:24275569
HDGF	P51858	101	163	132	132	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16807684,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16807684,PMID:17081983,PMID:17487921,PMID:18088087,PMID:18318008,PMID:19367720,PMID:19690332,PMID:23186163,PMID:24275569
HDGF	P51858	101	163	133	133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16807684,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16807684,PMID:17081983,PMID:17487921,PMID:18088087,PMID:18318008,PMID:19367720,PMID:20068231,PMID:23186163,PMID:24275569
HDGF	P51858	101	163	133	133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16807684,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16807684,PMID:17081983,PMID:17487921,PMID:18088087,PMID:18318008,PMID:19367720,PMID:20068231,PMID:23186163,PMID:24275569
HEATR6	Q6AI08	808	849	1	1181	Chain	ID=PRO_0000337173;Note=HEAT repeat-containing protein 6
HEATR6	Q6AI08	763	808	1	1181	Chain	ID=PRO_0000337173;Note=HEAT repeat-containing protein 6
HEATR6	Q6AI08	734	763	1	1181	Chain	ID=PRO_0000337173;Note=HEAT repeat-containing protein 6
HEATR6	Q6AI08	109	156	1	1181	Chain	ID=PRO_0000337173;Note=HEAT repeat-containing protein 6
HEATR6	Q6AI08	734	763	753	753	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HEATR6	Q6AI08	734	763	762	762	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
HEATR6	Q6AI08	763	808	778	778	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
HECTD1	Q9ULT8	1891	1952	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1705	1746	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1307	1586	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1085	1192	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	411	444	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	201	295	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1891	1952	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1705	1746	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1307	1586	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	1085	1192	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	411	444	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	201	295	1	2610	Chain	ID=PRO_0000083945;Note=E3 ubiquitin-protein ligase HECTD1
HECTD1	Q9ULT8	411	444	395	424	Repeat	Note=ANK 1
HECTD1	Q9ULT8	411	444	395	424	Repeat	Note=ANK 1
HECTD1	Q9ULT8	411	444	426	455	Repeat	Note=ANK 2
HECTD1	Q9ULT8	411	444	426	455	Repeat	Note=ANK 2
HECTD1	Q9ULT8	1307	1586	1266	1338	Domain	Note=MIB/HERC2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00749
HECTD1	Q9ULT8	1307	1586	1266	1338	Domain	Note=MIB/HERC2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00749
HECTD1	Q9ULT8	1307	1586	1350	1649	Compositional bias	Note=Ser-rich
HECTD1	Q9ULT8	1307	1586	1350	1649	Compositional bias	Note=Ser-rich
HECTD1	Q9ULT8	1307	1586	1384	1384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q69ZR2
HECTD1	Q9ULT8	1307	1586	1384	1384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q69ZR2
HECTD1	Q9ULT8	1307	1586	1488	1488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
HECTD1	Q9ULT8	1307	1586	1488	1488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
HECTD1	Q9ULT8	1307	1586	1567	1567	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q69ZR2
HECTD1	Q9ULT8	1307	1586	1567	1567	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q69ZR2
HECTD1	Q9ULT8	1307	1586	1309	1314	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1309	1314	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1315	1317	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DK3
HECTD1	Q9ULT8	1307	1586	1315	1317	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DK3
HECTD1	Q9ULT8	1307	1586	1319	1325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1319	1325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1326	1328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1326	1328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1332	1334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1307	1586	1332	1334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DKM
HECTD1	Q9ULT8	1891	1952	1896	1902	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1896	1902	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1905	1908	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1905	1908	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1910	1920	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1910	1920	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1923	1928	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1923	1928	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1935	1941	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1935	1941	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1944	1957	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD1	Q9ULT8	1891	1952	1944	1957	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LC3
HECTD2	Q5U5R9	397	433	1	776	Chain	ID=PRO_0000240851;Note=Probable E3 ubiquitin-protein ligase HECTD2
HECTD2	Q5U5R9	397	433	208	776	Alternative sequence	ID=VSP_044966;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HECW2	Q9P2P5	1382	1431	1	1572	Chain	ID=PRO_0000277667;Note=E3 ubiquitin-protein ligase HECW2
HECW2	Q9P2P5	1255	1305	1	1572	Chain	ID=PRO_0000277667;Note=E3 ubiquitin-protein ligase HECW2
HECW2	Q9P2P5	1112	1139	1	1572	Chain	ID=PRO_0000277667;Note=E3 ubiquitin-protein ligase HECW2
HECW2	Q9P2P5	1000	1045	1	1572	Chain	ID=PRO_0000277667;Note=E3 ubiquitin-protein ligase HECW2
HECW2	Q9P2P5	1000	1045	985	1018	Domain	Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
HECW2	Q9P2P5	1382	1431	1237	1572	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
HECW2	Q9P2P5	1255	1305	1237	1572	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
HECW2	Q9P2P5	1000	1045	737	1068	Region	Note=Interaction with TP73;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12890487;Dbxref=PMID:12890487
HECW2	Q9P2P5	1382	1431	214	1572	Alternative sequence	ID=VSP_059108;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HECW2	Q9P2P5	1255	1305	214	1572	Alternative sequence	ID=VSP_059108;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HECW2	Q9P2P5	1112	1139	214	1572	Alternative sequence	ID=VSP_059108;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
HECW2	Q9P2P5	1000	1045	214	1572	Alternative sequence	ID=VSP_059108;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FLT3	P36888	806	847	27	993	Chain	ID=PRO_0000016778;Note=Receptor-type tyrosine-protein kinase FLT3
FLT3	P36888	806	847	564	993	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLT3	P36888	806	847	610	943	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FLT3	P36888	806	847	811	811	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
FLT3	P36888	806	847	842	842	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16627759,ECO:0000269|PubMed:19477218,ECO:0000269|PubMed:21262971;Dbxref=PMID:16627759,PMID:19477218,PMID:21262971
FLT3	P36888	806	847	807	847	Alternative sequence	ID=VSP_041796;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FLT3	P36888	806	847	835	835	Natural variant	ID=VAR_065679;Note=In acute lymphoblastic leukemia patients and acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11290608,ECO:0000269|PubMed:14504097;Dbxref=dbSNP:rs121913487,PMID:11290608,PMID:14504097
FLT3	P36888	806	847	835	835	Natural variant	ID=VAR_065680;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11290608,ECO:0000269|PubMed:11442493,ECO:0000269|PubMed:14504097;Dbxref=dbSNP:rs121913488,PMID:11290608,PMID:11442493,PMID:14504097
FLT3	P36888	806	847	835	835	Natural variant	ID=VAR_065681;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11290608;Dbxref=dbSNP:rs121913488,PMID:11290608
FLT3	P36888	806	847	835	835	Natural variant	ID=VAR_065682;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11290608;Dbxref=dbSNP:rs121909646,PMID:11290608
FLT3	P36888	806	847	835	835	Natural variant	ID=VAR_065683;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11290608,ECO:0000269|PubMed:11442493,ECO:0000269|PubMed:14504097;Dbxref=dbSNP:rs121913488,PMID:11290608,PMID:11442493,PMID:14504097
FLT3	P36888	806	847	836	836	Natural variant	ID=VAR_065684;Note=In acute lymphoblastic leukemia patients%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14504097;Dbxref=dbSNP:rs121913232,PMID:14504097
FLT3	P36888	806	847	807	809	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	814	816	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	817	820	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	821	823	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	824	827	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	831	833	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	836	838	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLT3	P36888	806	847	842	845	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB
FLVCR1	Q9Y5Y0	294	341	1	555	Chain	ID=PRO_0000084844;Note=Feline leukemia virus subgroup C receptor-related protein 1
FLVCR1	Q9Y5Y0	399	435	1	555	Chain	ID=PRO_0000084844;Note=Feline leukemia virus subgroup C receptor-related protein 1
FLVCR1	Q9Y5Y0	294	341	276	296	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR1	Q9Y5Y0	294	341	297	331	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR1	Q9Y5Y0	294	341	332	352	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR1	Q9Y5Y0	399	435	394	401	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR1	Q9Y5Y0	399	435	402	422	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR1	Q9Y5Y0	399	435	423	424	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR1	Q9Y5Y0	399	435	425	445	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FMO3	P31513	44	107	2	532	Chain	ID=PRO_0000147654;Note=Dimethylaniline monooxygenase [N-oxide-forming] 3
FMO3	P31513	44	107	60	61	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO3	P31513	44	107	61	62	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO3	P31513	44	107	52	52	Natural variant	ID=VAR_008146;Note=In TMAU. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10479479;Dbxref=dbSNP:rs72549321,PMID:10479479
FMO3	P31513	44	107	61	61	Natural variant	ID=VAR_042706;Note=Loss of activity. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17050781;Dbxref=PMID:17050781
FMO3	P31513	44	107	61	61	Natural variant	ID=VAR_037307;Note=In TMAU%3B more than 90%25 reduction in catalytic efficiency toward trimethylamine%2C benzydamine and methyl p-tolyl sulfide. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11191884,ECO:0000269|PubMed:17531949;Dbxref=dbSNP:rs72549322,PMID:11191884,PMID:17531949
FMO3	P31513	44	107	66	66	Natural variant	ID=VAR_002423;Note=In TMAU%3B loss of activity%3B affects FAD binding. M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10338091,ECO:0000269|PubMed:17531949,ECO:0000269|PubMed:9536088;Dbxref=dbSNP:rs72549323,PMID:10338091,PMID:17531949,PMID:9536088
FOXP4	Q8IVH2	68	100	1	680	Chain	ID=PRO_0000091889;Note=Forkhead box protein P4
FOXP4	Q8IVH2	100	141	1	680	Chain	ID=PRO_0000091889;Note=Forkhead box protein P4
FOXP4	Q8IVH2	478	512	1	680	Chain	ID=PRO_0000091889;Note=Forkhead box protein P4
FOXP4	Q8IVH2	68	100	1	680	Chain	ID=PRO_0000091889;Note=Forkhead box protein P4
FOXP4	Q8IVH2	100	141	1	680	Chain	ID=PRO_0000091889;Note=Forkhead box protein P4
FOXP4	Q8IVH2	478	512	1	680	Chain	ID=PRO_0000091889;Note=Forkhead box protein P4
FOXP4	Q8IVH2	478	512	467	559	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXP4	Q8IVH2	478	512	467	559	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXP4	Q8IVH2	68	100	65	219	Compositional bias	Note=Gln-rich
FOXP4	Q8IVH2	100	141	65	219	Compositional bias	Note=Gln-rich
FOXP4	Q8IVH2	68	100	65	219	Compositional bias	Note=Gln-rich
FOXP4	Q8IVH2	100	141	65	219	Compositional bias	Note=Gln-rich
FOXP4	Q8IVH2	68	100	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FOXP4	Q8IVH2	68	100	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FOXP4	Q8IVH2	100	141	141	142	Alternative sequence	ID=VSP_043034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXP4	Q8IVH2	100	141	141	142	Alternative sequence	ID=VSP_043034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXM1	Q08050	325	340	1	763	Chain	ID=PRO_0000091863;Note=Forkhead box protein M1
FOXM1	Q08050	282	325	1	763	Chain	ID=PRO_0000091863;Note=Forkhead box protein M1
FOXM1	Q08050	325	340	235	327	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXM1	Q08050	282	325	235	327	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXM1	Q08050	325	340	331	331	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
FOXM1	Q08050	325	340	325	325	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FOXM1	Q08050	282	325	325	325	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FOXM1	Q08050	325	340	326	340	Alternative sequence	ID=VSP_001547;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9032290;Dbxref=PMID:15489334,PMID:9032290
FOXM1	Q08050	282	325	281	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G73
FOXM1	Q08050	282	325	295	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G73
FOXM1	Q08050	282	325	306	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G73
FOXM1	Q08050	282	325	312	314	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G73
ALAS2	P22557	101	138	50	587	Chain	ID=PRO_0000001223;Note=5-aminolevulinate synthase%2C erythroid-specific%2C mitochondrial
ALAS2	P22557	101	138	1	142	Alternative sequence	ID=VSP_042851;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALAS2	P22557	101	138	102	138	Alternative sequence	ID=VSP_042852;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FRMD4A	Q9P2Q2	534	553	1	1039	Chain	ID=PRO_0000219444;Note=FERM domain-containing protein 4A
FRMD4A	Q9P2Q2	417	458	1	1039	Chain	ID=PRO_0000219444;Note=FERM domain-containing protein 4A
FRMD4A	Q9P2Q2	155	182	1	1039	Chain	ID=PRO_0000219444;Note=FERM domain-containing protein 4A
FRMD4A	Q9P2Q2	69	99	1	1039	Chain	ID=PRO_0000219444;Note=FERM domain-containing protein 4A
FRMD4A	Q9P2Q2	155	182	20	322	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD4A	Q9P2Q2	69	99	20	322	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD4A	Q9P2Q2	417	458	358	420	Region	Note=Necessary for interaction with CYTH1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BIE6
FRMD8	Q9BZ67	28	84	1	464	Chain	ID=PRO_0000295778;Note=FERM domain-containing protein 8
FRMD8	Q9BZ67	84	118	1	464	Chain	ID=PRO_0000295778;Note=FERM domain-containing protein 8
FRMD8	Q9BZ67	194	267	1	464	Chain	ID=PRO_0000295778;Note=FERM domain-containing protein 8
FRMD8	Q9BZ67	28	84	30	376	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD8	Q9BZ67	84	118	30	376	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD8	Q9BZ67	194	267	30	376	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD8	Q9BZ67	28	84	29	84	Alternative sequence	ID=VSP_027085;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FRMD8	Q9BZ67	84	118	29	84	Alternative sequence	ID=VSP_027085;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FRMD8	Q9BZ67	84	118	85	118	Alternative sequence	ID=VSP_056059;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FRMD8	Q9BZ67	194	267	198	198	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
FSTL1	Q12841	99	110	21	308	Chain	ID=PRO_0000010111;Note=Follistatin-related protein 1
FSTL1	Q12841	21	56	21	308	Chain	ID=PRO_0000010111;Note=Follistatin-related protein 1
FSTL1	Q12841	21	56	30	53	Domain	Note=Follistatin-like
FSTL1	Q12841	99	110	48	100	Domain	Note=Kazal-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL1	Q12841	21	56	48	100	Domain	Note=Kazal-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL1	Q12841	21	56	54	84	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL1	Q12841	21	56	22	56	Alternative sequence	ID=VSP_055075;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FSTL3	O95633	96	168	27	263	Chain	ID=PRO_0000010115;Note=Follistatin-related protein 3
FSTL3	O95633	168	244	27	263	Chain	ID=PRO_0000010115;Note=Follistatin-related protein 3
FSTL3	O95633	96	168	36	107	Domain	Note=TB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697
FSTL3	O95633	96	168	99	119	Domain	Note=Follistatin-like 1
FSTL3	O95633	96	168	113	169	Domain	Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL3	O95633	168	244	113	169	Domain	Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL3	O95633	168	244	170	193	Domain	Note=Follistatin-like 2
FSTL3	O95633	168	244	189	245	Domain	Note=Kazal-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL3	O95633	168	244	215	215	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18768470;Dbxref=PMID:18768470
FSTL3	O95633	96	168	99	110	Disulfide bond	.
FSTL3	O95633	96	168	104	119	Disulfide bond	.
FSTL3	O95633	96	168	121	153	Disulfide bond	.
FSTL3	O95633	96	168	125	146	Disulfide bond	.
FSTL3	O95633	96	168	135	167	Disulfide bond	.
FSTL3	O95633	168	244	171	182	Disulfide bond	.
FSTL3	O95633	168	244	176	192	Disulfide bond	.
FSTL3	O95633	168	244	195	229	Disulfide bond	.
FSTL3	O95633	168	244	200	222	Disulfide bond	.
FSTL3	O95633	168	244	211	243	Disulfide bond	.
FSTL3	O95633	96	168	97	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	108	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	113	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B4V
FSTL3	O95633	96	168	118	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	141	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	145	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	96	168	161	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	181	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	204	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	210	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	217	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	221	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FSTL3	O95633	168	244	237	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK
FCGR2B	P31994	253	272	43	310	Chain	ID=PRO_0000015147;Note=Low affinity immunoglobulin gamma Fc region receptor II-b
FCGR2B	P31994	253	272	241	310	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR2B	P31994	253	272	254	272	Alternative sequence	ID=VSP_002643;Note=In isoform IIB2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2142460,ECO:0000303|PubMed:2529342,ECO:0000303|PubMed:2531080,ECO:0000303|Ref.1,ECO:0000303|Ref.5;Dbxref=PMID:15489334,PMID:2142460,PMID:2529342,PMID:2531080
FCGR2B	P31994	253	272	258	258	Natural variant	ID=VAR_008798;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8466861;Dbxref=dbSNP:rs148534844,PMID:8466861
FCGR3A	P08637	106	192	17	254	Chain	ID=PRO_0000015150;Note=Low affinity immunoglobulin gamma Fc region receptor III-A
FCGR3A	P08637	141	227	17	254	Chain	ID=PRO_0000015150;Note=Low affinity immunoglobulin gamma Fc region receptor III-A
FCGR3A	P08637	106	192	17	208	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR3A	P08637	141	227	17	208	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR3A	P08637	141	227	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR3A	P08637	106	192	107	189	Domain	Note=Ig-like C2-type 2
FCGR3A	P08637	141	227	107	189	Domain	Note=Ig-like C2-type 2
FCGR3A	P08637	106	192	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21768335,ECO:0000269|PubMed:22023369;Dbxref=PMID:21768335,PMID:22023369
FCGR3A	P08637	141	227	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21768335,ECO:0000269|PubMed:22023369;Dbxref=PMID:21768335,PMID:22023369
FCGR3A	P08637	106	192	187	187	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR3A	P08637	141	227	187	187	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCGR3A	P08637	106	192	128	172	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3AY4,ECO:0000244|PDB:3SGJ,ECO:0000244|PDB:3SGK,ECO:0000269|PubMed:21768335,ECO:0000269|PubMed:22023369;Dbxref=PMID:21768335,PMID:22023369
FCGR3A	P08637	141	227	128	172	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3AY4,ECO:0000244|PDB:3SGJ,ECO:0000244|PDB:3SGK,ECO:0000269|PubMed:21768335,ECO:0000269|PubMed:22023369;Dbxref=PMID:21768335,PMID:22023369
FCGR3A	P08637	106	192	147	147	Natural variant	ID=VAR_058398;Note=G->D;Dbxref=dbSNP:rs443082
FCGR3A	P08637	141	227	147	147	Natural variant	ID=VAR_058398;Note=G->D;Dbxref=dbSNP:rs443082
FCGR3A	P08637	106	192	158	158	Natural variant	ID=VAR_058399;Note=Y->H;Dbxref=dbSNP:rs396716
FCGR3A	P08637	141	227	158	158	Natural variant	ID=VAR_058399;Note=Y->H;Dbxref=dbSNP:rs396716
FCGR3A	P08637	106	192	176	176	Natural variant	ID=VAR_003960;Note=Shows a higher binding capacity of IgG1%2C IgG3 and IgG4. F->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7700021,ECO:0000269|PubMed:9242542,ECO:0000269|PubMed:9276722,ECO:0000269|Ref.3;Dbxref=dbSNP:rs396991,PMID:15489334,PMID:7700021,PMID:9242542,PMID:9276722
FCGR3A	P08637	141	227	176	176	Natural variant	ID=VAR_003960;Note=Shows a higher binding capacity of IgG1%2C IgG3 and IgG4. F->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7700021,ECO:0000269|PubMed:9242542,ECO:0000269|PubMed:9276722,ECO:0000269|Ref.3;Dbxref=dbSNP:rs396991,PMID:15489334,PMID:7700021,PMID:9242542,PMID:9276722
FCGR3A	P08637	141	227	203	203	Natural variant	ID=VAR_058400;Note=F->S;Dbxref=dbSNP:rs1042206
FCGR3A	P08637	106	192	106	106	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGR3A	P08637	106	192	106	106	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGR3A	P08637	141	227	195	195	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCGR3A	P08637	106	192	107	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	116	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	124	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	131	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	146	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	146	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	164	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	164	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	168	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	168	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	179	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	179	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	106	192	186	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FCGR3A	P08637	141	227	186	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AY4
FBXL4	Q9UKA2	439	463	1	621	Chain	ID=PRO_0000119844;Note=F-box/LRR-repeat protein 4
FBXL4	Q9UKA2	439	463	1	621	Chain	ID=PRO_0000119844;Note=F-box/LRR-repeat protein 4
FBXL4	Q9UKA2	439	463	427	448	Repeat	Note=LRR 3
FBXL4	Q9UKA2	439	463	427	448	Repeat	Note=LRR 3
FBXL4	Q9UKA2	439	463	452	474	Repeat	Note=LRR 4
FBXL4	Q9UKA2	439	463	452	474	Repeat	Note=LRR 4
HAT1	O14929	2	37	2	419	Chain	ID=PRO_0000083902;Note=Histone acetyltransferase type B catalytic subunit
HAT1	O14929	204	238	2	419	Chain	ID=PRO_0000083902;Note=Histone acetyltransferase type B catalytic subunit
HAT1	O14929	325	364	2	419	Chain	ID=PRO_0000083902;Note=Histone acetyltransferase type B catalytic subunit
HAT1	O14929	204	238	225	227	Region	Note=Interaction with histone H4 N-terminus;Ontology_term=ECO:0000305;evidence=ECO:0000305
HAT1	O14929	2	37	2	2	Modified residue	Note=N-acetylalanine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895;Dbxref=PMID:19413330,PMID:22223895
HAT1	O14929	2	37	9	9	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BY71
HAT1	O14929	2	37	15	15	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BY71
HAT1	O14929	325	364	343	343	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HAT1	O14929	2	37	1	85	Alternative sequence	ID=VSP_041129;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HAT1	O14929	2	37	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	2	37	29	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	2	37	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	204	238	199	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	204	238	213	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	204	238	230	232	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	204	238	233	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAT1	O14929	325	364	325	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0W
HAUS5	O94927	393	420	1	633	Chain	ID=PRO_0000050776;Note=HAUS augmin-like complex subunit 5
HAUS5	O94927	393	420	375	403	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HAUS5	O94927	393	420	291	633	Alternative sequence	ID=VSP_013928;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FGD5	Q6ZNL6	1051	1068	1	1462	Chain	ID=PRO_0000080950;Note=FYVE%2C RhoGEF and PH domain-containing protein 5
FGD5	Q6ZNL6	1088	1112	1	1462	Chain	ID=PRO_0000080950;Note=FYVE%2C RhoGEF and PH domain-containing protein 5
FGD5	Q6ZNL6	1135	1163	1	1462	Chain	ID=PRO_0000080950;Note=FYVE%2C RhoGEF and PH domain-containing protein 5
FGD5	Q6ZNL6	1356	1399	1	1462	Chain	ID=PRO_0000080950;Note=FYVE%2C RhoGEF and PH domain-containing protein 5
FGD5	Q6ZNL6	1051	1068	892	1084	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
FGD5	Q6ZNL6	1135	1163	1113	1207	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD5	Q6ZNL6	1356	1399	1363	1461	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FGD5	Q6ZNL6	1088	1112	1112	1112	Sequence conflict	Note=R->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGD5	Q6ZNL6	1356	1399	1382	1382	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGD5	Q6ZNL6	1051	1068	1032	1054	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MPX
FGD5	Q6ZNL6	1051	1068	1062	1084	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MPX
FGD5	Q6ZNL6	1088	1112	1088	1100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MPX
FGD5	Q6ZNL6	1135	1163	1127	1145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MPX
FGD5	Q6ZNL6	1135	1163	1151	1158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MPX
FHAD1	B1AJZ9	31	100	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	226	305	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	390	420	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	420	455	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	455	491	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	760	796	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	1213	1245	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	31	100	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	226	305	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	390	420	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	420	455	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	455	491	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	760	796	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	1213	1245	1	1412	Chain	ID=PRO_0000349365;Note=Forkhead-associated domain-containing protein 1
FHAD1	B1AJZ9	31	100	18	69	Domain	Note=FHA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00086
FHAD1	B1AJZ9	31	100	18	69	Domain	Note=FHA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00086
FHAD1	B1AJZ9	226	305	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	390	420	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	420	455	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	455	491	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	226	305	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	390	420	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	420	455	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	455	491	250	466	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	760	796	692	963	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	760	796	692	963	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FHAD1	B1AJZ9	31	100	98	160	Compositional bias	Note=Pro-rich
FHAD1	B1AJZ9	31	100	98	160	Compositional bias	Note=Pro-rich
FHAD1	B1AJZ9	760	796	758	793	Alternative sequence	ID=VSP_035366;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FHAD1	B1AJZ9	760	796	758	793	Alternative sequence	ID=VSP_035366;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FHAD1	B1AJZ9	760	796	763	763	Natural variant	ID=VAR_046372;Note=E->K;Dbxref=dbSNP:rs12126178
FHAD1	B1AJZ9	760	796	763	763	Natural variant	ID=VAR_046372;Note=E->K;Dbxref=dbSNP:rs12126178
HBEGF	Q99075	133	184	20	208	Chain	ID=PRO_0000302803;Note=Proheparin-binding EGF-like growth factor
HBEGF	Q99075	133	184	63	148	Chain	ID=PRO_0000007612;Note=Heparin-binding EGF-like growth factor
HBEGF	Q99075	133	184	149	208	Propeptide	ID=PRO_0000007613;Note=C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255
HBEGF	Q99075	133	184	20	160	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HBEGF	Q99075	133	184	161	184	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HBEGF	Q99075	133	184	104	144	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HBEGF	Q99075	133	184	141	141	Site	Note=Plays a critical role in diphtheria toxin binding and toxin sensitivity;Ontology_term=ECO:0000250;evidence=ECO:0000250
HBEGF	Q99075	133	184	134	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HBEGF	Q99075	133	184	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XDT
HBEGF	Q99075	133	184	138	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XDT
FLNC	Q14315	1733	1766	1	2725	Chain	ID=PRO_0000087301;Note=Filamin-C
FLNC	Q14315	1733	1766	1635	1734	Repeat	Note=Filamin 15
FLNC	Q14315	1733	1766	1759	1853	Repeat	Note=Filamin 16
FLNC	Q14315	1733	1766	1735	1758	Region	Note=Hinge 1
FLNC	Q14315	1733	1766	1734	1766	Alternative sequence	ID=VSP_007579;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10629222,ECO:0000303|PubMed:10658210,ECO:0000303|PubMed:7689010;Dbxref=PMID:10629222,PMID:10658210,PMID:7689010
FMN2	Q9NZ56	1528	1548	1	1722	Chain	ID=PRO_0000194888;Note=Formin-2
FMN2	Q9NZ56	1588	1619	1	1722	Chain	ID=PRO_0000194888;Note=Formin-2
FMN2	Q9NZ56	1528	1548	1283	1698	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
FMN2	Q9NZ56	1588	1619	1283	1698	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
FMN2	Q9NZ56	1588	1619	1567	1597	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FMO4	P31512	44	107	1	558	Chain	ID=PRO_0000147660;Note=Dimethylaniline monooxygenase [N-oxide-forming] 4
FMO4	P31512	44	107	60	61	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FOSL1	P15407	99	135	1	271	Chain	ID=PRO_0000076479;Note=Fos-related antigen 1
FOSL1	P15407	33	99	1	271	Chain	ID=PRO_0000076479;Note=Fos-related antigen 1
FOSL1	P15407	99	135	105	168	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
FOSL1	P15407	99	135	107	127	Region	Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
FOSL1	P15407	99	135	133	161	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
FOSL1	P15407	99	135	103	106	Compositional bias	Note=Poly-Glu
FOSL1	P15407	99	135	34	135	Alternative sequence	ID=VSP_055566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FOSL1	P15407	33	99	34	135	Alternative sequence	ID=VSP_055566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX10	Q13206	749	768	1	875	Chain	ID=PRO_0000055083;Note=Probable ATP-dependent RNA helicase DDX10
DNAJA4	Q8WW22	215	292	1	394	Chain	ID=PRO_0000071014;Note=DnaJ homolog subfamily A member 4
DNAJA4	Q8WW22	215	292	1	394	Chain	ID=PRO_0000071014;Note=DnaJ homolog subfamily A member 4
DNAJA4	Q8WW22	215	292	226	226	Natural variant	ID=VAR_069064;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852881,PMID:15489334
DNAJA4	Q8WW22	215	292	226	226	Natural variant	ID=VAR_069064;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852881,PMID:15489334
DBH	P09172	445	458	1	617	Chain	ID=PRO_0000006356;Note=Dopamine beta-hydroxylase
DBH	P09172	445	458	40	617	Chain	ID=PRO_0000308209;Note=Soluble dopamine beta-hydroxylase
DBH	P09172	445	458	38	617	Topological domain	Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DBH	P09172	445	458	154	596	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZEL,ECO:0000269|PubMed:27152332;Dbxref=PMID:27152332
DBH	P09172	445	458	390	503	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZEL,ECO:0000269|PubMed:27152332;Dbxref=PMID:27152332
DBH	P09172	445	458	394	565	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZEL,ECO:0000269|PubMed:27152332;Dbxref=PMID:27152332
DBH	P09172	445	458	448	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZEL
POLE4	Q9NR33	99	113	2	117	Chain	ID=PRO_0000191746;Note=DNA polymerase epsilon subunit 4
GPC3	P51654	389	430	359	554	Chain	ID=PRO_0000445411;Note=Glypican-3 beta subunit;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14610063;Dbxref=PMID:14610063
GPC3	P51654	389	430	418	418	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29345911;Dbxref=PMID:29345911
GPC3	P51654	389	430	274	422	Disulfide bond	Note=Interchain (between alpha and beta chains);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35052
GPC3	P51654	389	430	278	410	Disulfide bond	Note=Interchain (between alpha and beta chains);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35052
GPC3	P51654	389	430	429	429	Natural variant	ID=VAR_069139;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs11539789
GPC3	P51654	389	430	387	389	Mutagenesis	Note=No effect on proteolytic processing. RRR->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610063;Dbxref=PMID:14610063
GPC3	P51654	389	430	394	396	Mutagenesis	Note=No effect on proteolytic processing. KLK->ALA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610063;Dbxref=PMID:14610063
POLM	Q9NP87	157	214	1	494	Chain	ID=PRO_0000218787;Note=DNA-directed DNA/RNA polymerase mu
POLM	Q9NP87	124	157	1	494	Chain	ID=PRO_0000218787;Note=DNA-directed DNA/RNA polymerase mu
POLM	Q9NP87	124	157	142	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
POLM	Q9NP87	157	214	154	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
POLM	Q9NP87	124	157	154	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
POLM	Q9NP87	157	214	173	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
POLM	Q9NP87	157	214	189	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
POLM	Q9NP87	157	214	196	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
POLM	Q9NP87	157	214	207	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VZB
IQCG	Q9H095	365	399	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	321	365	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	296	321	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	172	214	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	365	399	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	321	365	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	296	321	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	172	214	1	443	Chain	ID=PRO_0000282561;Note=Dynein regulatory complex protein 9
IQCG	Q9H095	365	399	393	422	Domain	Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQCG	Q9H095	365	399	393	422	Domain	Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQCG	Q9H095	172	214	177	177	Sequence conflict	Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
IQCG	Q9H095	172	214	177	177	Sequence conflict	Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
IQCG	Q9H095	365	399	389	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LZX
IQCG	Q9H095	365	399	389	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LZX
GBE1	Q04446	261	330	2	702	Chain	ID=PRO_0000188775;Note=1%2C4-alpha-glucan-branching enzyme
GBE1	Q04446	261	330	265	265	Natural variant	ID=VAR_034747;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856389,PMID:15489334
GBE1	Q04446	261	330	329	329	Natural variant	ID=VAR_022431;Note=In GSD4%3B non-progressive form%3B impairs protein stability%3B 50%25 residual activity. Y->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26199317,ECO:0000269|PubMed:8613547;Dbxref=dbSNP:rs80338671,PMID:26199317,PMID:8613547
GBE1	Q04446	261	330	261	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	266	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	282	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	292	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CLT
GBE1	Q04446	261	330	296	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	301	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	305	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	315	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GBE1	Q04446	261	330	320	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BZY
GLI1	P08151	33	64	1	1106	Chain	ID=PRO_0000047197;Note=Zinc finger protein GLI1
GLI1	P08151	359	436	1	1106	Chain	ID=PRO_0000047197;Note=Zinc finger protein GLI1
GLI1	P08151	359	436	362	387	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GLI1	P08151	359	436	375	381	Region	Note=Interaction with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8378770;Dbxref=PMID:8378770
GLI1	P08151	33	64	1	128	Alternative sequence	ID=VSP_054829;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLI1	P08151	33	64	34	74	Alternative sequence	ID=VSP_042215;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19706761;Dbxref=PMID:19706761
GLI1	P08151	359	436	367	369	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GLI
GLI1	P08151	359	436	372	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GLI
GLI1	P08151	359	436	376	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GLI
GLI1	P08151	359	436	382	384	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GLI
GALNT11	Q8NCW6	195	237	1	608	Chain	ID=PRO_0000059125;Note=Polypeptide N-acetylgalactosaminyltransferase 11
GALNT11	Q8NCW6	195	237	1	608	Chain	ID=PRO_0000059125;Note=Polypeptide N-acetylgalactosaminyltransferase 11
GALNT11	Q8NCW6	195	237	30	608	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT11	Q8NCW6	195	237	30	608	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT11	Q8NCW6	195	237	150	261	Region	Note=Catalytic subdomain A
GALNT11	Q8NCW6	195	237	150	261	Region	Note=Catalytic subdomain A
GALNT11	Q8NCW6	195	237	222	222	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT11	Q8NCW6	195	237	222	222	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT11	Q8NCW6	195	237	141	373	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT11	Q8NCW6	195	237	141	373	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT11	Q8NCW6	195	237	196	202	Alternative sequence	ID=VSP_011215;Note=In isoform 2. DDLKGEL->GKECCTW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT11	Q8NCW6	195	237	196	202	Alternative sequence	ID=VSP_011215;Note=In isoform 2. DDLKGEL->GKECCTW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT11	Q8NCW6	195	237	203	608	Alternative sequence	ID=VSP_011216;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT11	Q8NCW6	195	237	203	608	Alternative sequence	ID=VSP_011216;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT11	Q8NCW6	195	237	197	197	Natural variant	ID=VAR_019590;Note=D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20547088;Dbxref=dbSNP:rs3778922,PMID:20547088
GALNT11	Q8NCW6	195	237	197	197	Natural variant	ID=VAR_019590;Note=D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20547088;Dbxref=dbSNP:rs3778922,PMID:20547088
GALNT18	Q6P9A2	504	559	1	607	Chain	ID=PRO_0000059141;Note=Polypeptide N-acetylgalactosaminyltransferase 18
GALNT18	Q6P9A2	472	504	1	607	Chain	ID=PRO_0000059141;Note=Polypeptide N-acetylgalactosaminyltransferase 18
GALNT18	Q6P9A2	426	472	1	607	Chain	ID=PRO_0000059141;Note=Polypeptide N-acetylgalactosaminyltransferase 18
GALNT18	Q6P9A2	260	325	1	607	Chain	ID=PRO_0000059141;Note=Polypeptide N-acetylgalactosaminyltransferase 18
GALNT18	Q6P9A2	504	559	36	607	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT18	Q6P9A2	472	504	36	607	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT18	Q6P9A2	426	472	36	607	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT18	Q6P9A2	260	325	36	607	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT18	Q6P9A2	504	559	469	599	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	472	504	469	599	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	426	472	469	599	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	260	325	153	267	Region	Note=Catalytic subdomain A
GALNT18	Q6P9A2	260	325	324	385	Region	Note=Catalytic subdomain B
GALNT18	Q6P9A2	260	325	320	320	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT18	Q6P9A2	260	325	144	377	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	426	472	368	447	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	472	504	482	498	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	504	559	530	543	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT18	Q6P9A2	504	559	92	607	Alternative sequence	ID=VSP_011235;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
GALNT18	Q6P9A2	472	504	92	607	Alternative sequence	ID=VSP_011235;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
GALNT18	Q6P9A2	426	472	92	607	Alternative sequence	ID=VSP_011235;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
GALNT18	Q6P9A2	260	325	92	607	Alternative sequence	ID=VSP_011235;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
GALNT18	Q6P9A2	504	559	541	541	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GOSR1	O95249	172	181	2	250	Chain	ID=PRO_0000212542;Note=Golgi SNAP receptor complex member 1
GOSR1	O95249	172	181	2	229	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR143	P51810	152	182	1	404	Chain	ID=PRO_0000195086;Note=G-protein coupled receptor 143
GPR143	P51810	152	182	150	170	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR143	P51810	152	182	171	191	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR143	P51810	152	182	152	152	Natural variant	ID=VAR_005515;Note=In OA1. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9529334;Dbxref=dbSNP:rs58933950,PMID:9529334
GPR143	P51810	152	182	166	166	Natural variant	ID=VAR_063271;Note=In OA1. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16646960;Dbxref=PMID:16646960
GPR143	P51810	152	182	173	173	Natural variant	ID=VAR_005516;Note=In OA1%3B results in altered glycosylation pattern and subcellular localization consistent with protein retention in the endoplasmic reticulum. A->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11115845,ECO:0000269|PubMed:8634705;Dbxref=dbSNP:rs62635035,PMID:11115845,PMID:8634705
GPR156	Q8NFN8	232	311	1	814	Chain	ID=PRO_0000206899;Note=Probable G-protein coupled receptor 156
GPR156	Q8NFN8	158	200	1	814	Chain	ID=PRO_0000206899;Note=Probable G-protein coupled receptor 156
GPR156	Q8NFN8	232	311	1	814	Chain	ID=PRO_0000206899;Note=Probable G-protein coupled receptor 156
GPR156	Q8NFN8	158	200	1	814	Chain	ID=PRO_0000206899;Note=Probable G-protein coupled receptor 156
GPR156	Q8NFN8	158	200	140	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	158	200	140	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	158	200	165	185	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	158	200	165	185	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	158	200	186	222	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	158	200	186	222	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	223	243	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	223	243	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	244	257	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	244	257	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	258	278	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	258	278	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	279	288	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	279	288	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	289	309	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	289	309	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	310	814	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	232	311	310	814	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR156	Q8NFN8	158	200	197	200	Alternative sequence	ID=VSP_044603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GPR156	Q8NFN8	158	200	197	200	Alternative sequence	ID=VSP_044603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GCA	P28676	151	189	1	217	Chain	ID=PRO_0000073721;Note=Grancalcin
GCA	P28676	151	189	119	154	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GCA	P28676	151	189	155	180	Domain	Note=EF-hand 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GCA	P28676	151	189	161	172	Calcium binding	Note=3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GCA	P28676	151	189	166	166	Sequence conflict	Note=R->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
GCA	P28676	151	189	157	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K94
GCA	P28676	151	189	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F4O
GCA	P28676	151	189	172	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F4Q
GCA	P28676	151	189	175	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K94
HABP4	Q5JVS0	171	224	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	225	247	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	248	275	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	333	395	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	333	395	354	354	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14699138;Dbxref=PMID:14699138
HABP4	Q5JVS0	333	395	375	375	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14699138;Dbxref=PMID:14699138
HABP4	Q5JVS0	171	224	172	276	Alternative sequence	ID=VSP_052194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HABP4	Q5JVS0	225	247	172	276	Alternative sequence	ID=VSP_052194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HABP4	Q5JVS0	248	275	172	276	Alternative sequence	ID=VSP_052194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HABP4	Q5JVS0	333	395	388	389	Sequence conflict	Note=YG->NY;Ontology_term=ECO:0000305;evidence=ECO:0000305
HABP4	Q5JVS0	333	395	388	389	Sequence conflict	Note=YG->NY;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNA15	P30679	162	204	1	374	Chain	ID=PRO_0000203755;Note=Guanine nucleotide-binding protein subunit alpha-15
GNA15	P30679	162	204	183	189	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNA15	P30679	162	204	189	189	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNA15	P30679	162	204	186	186	Modified residue	Note=ADP-ribosylarginine%3B by cholera toxin;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNB5	O14775	209	257	1	395	Chain	ID=PRO_0000127705;Note=Guanine nucleotide-binding protein subunit beta-5
GNB5	O14775	125	139	1	395	Chain	ID=PRO_0000127705;Note=Guanine nucleotide-binding protein subunit beta-5
GNB5	O14775	125	139	103	142	Repeat	Note=WD 1
GNB5	O14775	209	257	193	234	Repeat	Note=WD 3
GNB5	O14775	209	257	236	278	Repeat	Note=WD 4
GNB5	O14775	209	257	140	209	Alternative sequence	ID=VSP_039101;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
GNB5	O14775	209	257	213	213	Natural variant	ID=VAR_049270;Note=A->V;Dbxref=dbSNP:rs34637551
GNB5	O14775	209	257	223	223	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNL3	Q9BVP2	24	70	1	549	Chain	ID=PRO_0000122444;Note=Guanine nucleotide-binding protein-like 3
GNL3	Q9BVP2	70	108	1	549	Chain	ID=PRO_0000122444;Note=Guanine nucleotide-binding protein-like 3
GNL3	Q9BVP2	24	70	2	46	Region	Note=Basic;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNL3	Q9BVP2	24	70	56	95	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GNL3	Q9BVP2	70	108	56	95	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GNL3	Q9BVP2	70	108	79	79	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GNL3	Q9BVP2	70	108	101	101	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q811S9
GNL3	Q9BVP2	70	108	91	91	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GNL3	Q9BVP2	70	108	99	99	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:28112733
GNL3	Q9BVP2	24	70	39	39	Natural variant	ID=VAR_022160;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11085516,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16012751;Dbxref=dbSNP:rs11177,PMID:11085516,PMID:15489334,PMID:16012751
GNL3	Q9BVP2	70	108	86	86	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
GOLGA4	Q13439	54	159	1	2230	Chain	ID=PRO_0000190059;Note=Golgin subfamily A member 4
GOLGA4	Q13439	159	175	1	2230	Chain	ID=PRO_0000190059;Note=Golgin subfamily A member 4
GOLGA4	Q13439	175	194	1	2230	Chain	ID=PRO_0000190059;Note=Golgin subfamily A member 4
GOLGA4	Q13439	334	362	1	2230	Chain	ID=PRO_0000190059;Note=Golgin subfamily A member 4
GOLGA4	Q13439	2109	2132	1	2230	Chain	ID=PRO_0000190059;Note=Golgin subfamily A member 4
GOLGA4	Q13439	54	159	133	203	Region	Note=Interaction with MACF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15265687;Dbxref=PMID:15265687
GOLGA4	Q13439	159	175	133	203	Region	Note=Interaction with MACF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15265687;Dbxref=PMID:15265687
GOLGA4	Q13439	175	194	133	203	Region	Note=Interaction with MACF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15265687;Dbxref=PMID:15265687
GOLGA4	Q13439	54	159	133	2185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA4	Q13439	159	175	133	2185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA4	Q13439	175	194	133	2185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA4	Q13439	334	362	133	2185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA4	Q13439	2109	2132	133	2185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA4	Q13439	334	362	252	2096	Compositional bias	Note=Glu-rich
GOLGA4	Q13439	54	159	71	71	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
GOLGA4	Q13439	54	159	78	78	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
GOLGA4	Q13439	54	159	89	89	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
GOLGA4	Q13439	54	159	54	54	Alternative sequence	ID=VSP_044819;Note=In isoform 5. E->ENASTHASKSPDSVNGSEPSIPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GOLGA4	Q13439	2109	2132	2103	2109	Alternative sequence	ID=VSP_004274;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GOLGA4	Q13439	175	194	188	188	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
GOPC	Q9HD26	304	359	2	462	Chain	ID=PRO_0000087542;Note=Golgi-associated PDZ and coiled-coil motif-containing protein
GOPC	Q9HD26	272	304	2	462	Chain	ID=PRO_0000087542;Note=Golgi-associated PDZ and coiled-coil motif-containing protein
GOPC	Q9HD26	304	359	288	371	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
GOPC	Q9HD26	272	304	288	371	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
GOPC	Q9HD26	304	359	305	319	Alternative sequence	ID=VSP_016063;Note=In isoform 3. GGKEHGVPILISEIH->VRSSTSSIIFYSYLV;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GOPC	Q9HD26	304	359	320	462	Alternative sequence	ID=VSP_016064;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GOPC	Q9HD26	272	304	287	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	272	304	295	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMO
GOPC	Q9HD26	304	359	301	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	272	304	301	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	304	359	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	304	359	311	318	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	304	359	323	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	304	359	334	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GOPC	Q9HD26	304	359	342	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DC2
GOPC	Q9HD26	304	359	346	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LOB
GOPC	Q9HD26	304	359	349	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JOK
GPR108	Q9NPR9	80	97	33	543	Chain	ID=PRO_0000045083;Note=Protein GPR108
GPA33	Q99795	138	190	22	319	Chain	ID=PRO_0000014770;Note=Cell surface A33 antigen
GPA33	Q99795	138	190	22	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPA33	Q99795	138	190	140	227	Domain	Note=Ig-like C2-type
GPA33	Q99795	138	190	146	222	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
GPA33	Q99795	138	190	162	211	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
GPA33	Q99795	138	190	165	165	Natural variant	ID=VAR_049874;Note=K->N;Dbxref=dbSNP:rs2228399
GPAT2	Q6NUI2	632	676	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	606	632	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	273	344	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	84	118	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	21	59	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	632	676	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	606	632	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	273	344	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	84	118	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	21	59	1	795	Chain	ID=PRO_0000325853;Note=Glycerol-3-phosphate acyltransferase 2%2C mitochondrial
GPAT2	Q6NUI2	273	344	1	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	84	118	1	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	21	59	1	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	273	344	1	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	84	118	1	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	21	59	1	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	273	344	306	332	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	273	344	306	332	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	273	344	333	449	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	273	344	333	449	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	632	676	473	795	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	606	632	473	795	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	632	676	473	795	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	606	632	473	795	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAT2	Q6NUI2	273	344	180	331	Region	Note=Acyltransferase
GPAT2	Q6NUI2	273	344	180	331	Region	Note=Acyltransferase
GPAT2	Q6NUI2	632	676	656	656	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	656	656	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	660	660	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	660	660	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	662	662	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	662	662	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	664	664	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	632	676	664	664	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14DK4
GPAT2	Q6NUI2	84	118	1	216	Alternative sequence	ID=VSP_032450;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	21	59	1	216	Alternative sequence	ID=VSP_032450;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	84	118	1	216	Alternative sequence	ID=VSP_032450;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	21	59	1	216	Alternative sequence	ID=VSP_032450;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	273	344	274	344	Alternative sequence	ID=VSP_032451;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	273	344	274	344	Alternative sequence	ID=VSP_032451;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	632	676	633	671	Alternative sequence	ID=VSP_032453;Note=In isoform 2. TPGSRPACDTGRQRLSRKLLWKPSGDFTDSDSDDFGEAD->SWATQSSCSSSCRPPPRKKGSSSVRTQSSPSVLSGPSET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	632	676	633	671	Alternative sequence	ID=VSP_032453;Note=In isoform 2. TPGSRPACDTGRQRLSRKLLWKPSGDFTDSDSDDFGEAD->SWATQSSCSSSCRPPPRKKGSSSVRTQSSPSVLSGPSET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	632	676	672	795	Alternative sequence	ID=VSP_032454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	632	676	672	795	Alternative sequence	ID=VSP_032454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPAT2	Q6NUI2	273	344	336	336	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPAT2	Q6NUI2	273	344	336	336	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPN1	Q9HCN4	190	239	2	374	Chain	ID=PRO_0000066001;Note=GPN-loop GTPase 1
GPN1	Q9HCN4	310	346	2	374	Chain	ID=PRO_0000066001;Note=GPN-loop GTPase 1
GPN1	Q9HCN4	190	239	189	192	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UYR9
GPN1	Q9HCN4	310	346	312	312	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
GPN1	Q9HCN4	310	346	314	314	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
GPN1	Q9HCN4	310	346	328	328	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GPN1	Q9HCN4	310	346	338	338	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:24275569
GPN1	Q9HCN4	310	346	340	340	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
GREB1L	Q9C091	118	177	1	1923	Chain	ID=PRO_0000320946;Note=GREB1-like protein
GREB1L	Q9C091	464	573	1	1923	Chain	ID=PRO_0000320946;Note=GREB1-like protein
GREB1L	Q9C091	1757	1824	1	1923	Chain	ID=PRO_0000320946;Note=GREB1-like protein
GREB1L	Q9C091	118	177	1	1923	Chain	ID=PRO_0000320946;Note=GREB1-like protein
GREB1L	Q9C091	464	573	1	1923	Chain	ID=PRO_0000320946;Note=GREB1-like protein
GREB1L	Q9C091	1757	1824	1	1923	Chain	ID=PRO_0000320946;Note=GREB1-like protein
GREB1L	Q9C091	464	573	466	574	Alternative sequence	ID=VSP_031762;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GREB1L	Q9C091	464	573	466	574	Alternative sequence	ID=VSP_031762;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GREB1L	Q9C091	1757	1824	748	1923	Alternative sequence	ID=VSP_031765;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GREB1L	Q9C091	1757	1824	748	1923	Alternative sequence	ID=VSP_031765;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GREB1L	Q9C091	118	177	13	1923	Natural variant	ID=VAR_080091;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	464	573	13	1923	Natural variant	ID=VAR_080091;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	13	1923	Natural variant	ID=VAR_080091;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	118	177	13	1923	Natural variant	ID=VAR_080091;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	464	573	13	1923	Natural variant	ID=VAR_080091;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	13	1923	Natural variant	ID=VAR_080091;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	118	177	128	128	Natural variant	ID=VAR_080092;Note=In RHDA3. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	118	177	128	128	Natural variant	ID=VAR_080092;Note=In RHDA3. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	464	573	497	497	Natural variant	ID=VAR_080097;Note=In RHDA3. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	464	573	497	497	Natural variant	ID=VAR_080097;Note=In RHDA3. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	594	1923	Natural variant	ID=VAR_080098;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100091;Dbxref=PMID:29100091
GREB1L	Q9C091	1757	1824	594	1923	Natural variant	ID=VAR_080098;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100091;Dbxref=PMID:29100091
GREB1L	Q9C091	1757	1824	976	1923	Natural variant	ID=VAR_080105;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100091;Dbxref=PMID:29100091
GREB1L	Q9C091	1757	1824	976	1923	Natural variant	ID=VAR_080105;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100091;Dbxref=PMID:29100091
GREB1L	Q9C091	1757	1824	1099	1923	Natural variant	ID=VAR_080107;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	1099	1923	Natural variant	ID=VAR_080107;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	1560	1923	Natural variant	ID=VAR_080113;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	1560	1923	Natural variant	ID=VAR_080113;Note=In RHDA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100090;Dbxref=PMID:29100090
GREB1L	Q9C091	1757	1824	1775	1775	Natural variant	ID=VAR_080120;Note=In RHDA3. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100091;Dbxref=PMID:29100091
GREB1L	Q9C091	1757	1824	1775	1775	Natural variant	ID=VAR_080120;Note=In RHDA3. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100091;Dbxref=PMID:29100091
GREB1L	Q9C091	1757	1824	1793	1793	Natural variant	ID=VAR_080121;Note=In RHDA3. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28739660;Dbxref=PMID:28739660
GREB1L	Q9C091	1757	1824	1793	1793	Natural variant	ID=VAR_080121;Note=In RHDA3. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28739660;Dbxref=PMID:28739660
GRIA2	P42262	222	240	25	883	Chain	ID=PRO_0000011532;Note=Glutamate receptor 2
GRIA2	P42262	222	240	25	543	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA2	P42262	222	240	78	330	Disulfide bond	.
GRIA2	P42262	222	240	213	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WJW
GRIA2	P42262	222	240	230	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WJW
GRIA2	P42262	222	240	234	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WJW
GRIA2	P42262	222	240	239	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WJW
GRID1	Q9ULK0	411	445	21	1009	Chain	ID=PRO_0000011561;Note=Glutamate receptor ionotropic%2C delta-1
GRID1	Q9ULK0	242	260	21	1009	Chain	ID=PRO_0000011561;Note=Glutamate receptor ionotropic%2C delta-1
GRID1	Q9ULK0	78	173	21	1009	Chain	ID=PRO_0000011561;Note=Glutamate receptor ionotropic%2C delta-1
GRID1	Q9ULK0	411	445	21	562	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRID1	Q9ULK0	242	260	21	562	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRID1	Q9ULK0	78	173	21	562	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRID1	Q9ULK0	411	445	21	436	Region	Note=Interaction with CBLN1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61627
GRID1	Q9ULK0	242	260	21	436	Region	Note=Interaction with CBLN1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61627
GRID1	Q9ULK0	78	173	21	436	Region	Note=Interaction with CBLN1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61627
GRID1	Q9ULK0	411	445	422	422	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRID1	Q9ULK0	242	260	80	351	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61627
GRID1	Q9ULK0	78	173	80	351	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61627
GRID1	Q9ULK0	78	173	96	128	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61627
GRID1	Q9ULK0	411	445	1	429	Alternative sequence	ID=VSP_057019;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRID1	Q9ULK0	242	260	1	429	Alternative sequence	ID=VSP_057019;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRID1	Q9ULK0	78	173	1	429	Alternative sequence	ID=VSP_057019;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ISOC1	Q96CN7	103	143	1	298	Chain	ID=PRO_0000268664;Note=Isochorismatase domain-containing protein 1
GLB1L	Q6UWU2	447	491	28	654	Chain	ID=PRO_0000313604;Note=Beta-galactosidase-1-like protein
GLB1L	Q6UWU2	409	447	28	654	Chain	ID=PRO_0000313604;Note=Beta-galactosidase-1-like protein
GLB1L	Q6UWU2	379	409	28	654	Chain	ID=PRO_0000313604;Note=Beta-galactosidase-1-like protein
GLB1L	Q6UWU2	447	491	28	654	Chain	ID=PRO_0000313604;Note=Beta-galactosidase-1-like protein
GLB1L	Q6UWU2	409	447	28	654	Chain	ID=PRO_0000313604;Note=Beta-galactosidase-1-like protein
GLB1L	Q6UWU2	379	409	28	654	Chain	ID=PRO_0000313604;Note=Beta-galactosidase-1-like protein
SHMT2	P34897	198	239	30	504	Chain	ID=PRO_0000032562;Note=Serine hydroxymethyltransferase%2C mitochondrial
SHMT2	P34897	198	239	199	208	Alternative sequence	ID=VSP_043088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT2	P34897	198	239	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SHMT2	P34897	198	239	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V7I
SHMT2	P34897	198	239	206	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SHMT2	P34897	198	239	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SHMT2	P34897	198	239	234	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
GOLGA8R	I6L899	376	399	1	631	Chain	ID=PRO_0000420862;Note=Golgin subfamily A member 8R
GOLGA8R	I6L899	376	399	303	419	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA1	Q92805	469	499	1	767	Chain	ID=PRO_0000190052;Note=Golgin subfamily A member 1
GOLGA1	Q92805	437	469	1	767	Chain	ID=PRO_0000190052;Note=Golgin subfamily A member 1
GOLGA1	Q92805	323	355	1	767	Chain	ID=PRO_0000190052;Note=Golgin subfamily A member 1
GOLGA1	Q92805	144	187	1	767	Chain	ID=PRO_0000190052;Note=Golgin subfamily A member 1
GOLGA1	Q92805	75	100	1	767	Chain	ID=PRO_0000190052;Note=Golgin subfamily A member 1
GOLGA1	Q92805	469	499	50	657	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA1	Q92805	437	469	50	657	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA1	Q92805	323	355	50	657	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA1	Q92805	144	187	50	657	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA1	Q92805	75	100	50	657	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA1	Q92805	469	499	361	546	Compositional bias	Note=Gln-rich
GOLGA1	Q92805	437	469	361	546	Compositional bias	Note=Gln-rich
GOLGA7B	Q2TAP0	46	97	1	167	Chain	ID=PRO_0000244090;Note=Golgin subfamily A member 7B
GOLGA7B	Q2TAP0	46	97	78	78	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
GOLGA7B	Q2TAP0	46	97	81	81	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
GOLGA7B	Q2TAP0	46	97	83	83	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
GOLGA3	Q08378	1155	1194	1	1498	Chain	ID=PRO_0000190057;Note=Golgin subfamily A member 3
GOLGA3	Q08378	1089	1155	1	1498	Chain	ID=PRO_0000190057;Note=Golgin subfamily A member 3
GOLGA3	Q08378	1041	1089	1	1498	Chain	ID=PRO_0000190057;Note=Golgin subfamily A member 3
GOLGA3	Q08378	1155	1194	1	1498	Chain	ID=PRO_0000190057;Note=Golgin subfamily A member 3
GOLGA3	Q08378	1089	1155	1	1498	Chain	ID=PRO_0000190057;Note=Golgin subfamily A member 3
GOLGA3	Q08378	1041	1089	1	1498	Chain	ID=PRO_0000190057;Note=Golgin subfamily A member 3
GOLGA3	Q08378	1155	1194	394	1459	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA3	Q08378	1089	1155	394	1459	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA3	Q08378	1041	1089	394	1459	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA3	Q08378	1155	1194	394	1459	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA3	Q08378	1089	1155	394	1459	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA3	Q08378	1041	1089	394	1459	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA3	Q08378	1089	1155	1090	1134	Alternative sequence	ID=VSP_038000;Note=In isoform 3. LQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH->VRPGHLLWRQRGAGHVSPGHAATRETRRTKLHRVPSVATFGVATF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GOLGA3	Q08378	1089	1155	1090	1134	Alternative sequence	ID=VSP_038000;Note=In isoform 3. LQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH->VRPGHLLWRQRGAGHVSPGHAATRETRRTKLHRVPSVATFGVATF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GOLGA3	Q08378	1155	1194	1135	1498	Alternative sequence	ID=VSP_038001;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GOLGA3	Q08378	1089	1155	1135	1498	Alternative sequence	ID=VSP_038001;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GOLGA3	Q08378	1155	1194	1135	1498	Alternative sequence	ID=VSP_038001;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GOLGA3	Q08378	1089	1155	1135	1498	Alternative sequence	ID=VSP_038001;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GOLGA3	Q08378	1155	1194	1185	1185	Natural variant	ID=VAR_020154;Note=K->R;Dbxref=dbSNP:rs2291260
GOLGA3	Q08378	1155	1194	1185	1185	Natural variant	ID=VAR_020154;Note=K->R;Dbxref=dbSNP:rs2291260
GYS2	P54840	516	548	1	703	Chain	ID=PRO_0000194768;Note=Glycogen [starch] synthase%2C liver
HBS1L	Q9Y450	78	143	1	684	Chain	ID=PRO_0000091491;Note=HBS1-like protein
HBS1L	Q9Y450	36	78	1	684	Chain	ID=PRO_0000091491;Note=HBS1-like protein
HBS1L	Q9Y450	36	78	49	49	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HBS1L	Q9Y450	36	78	67	67	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HBS1L	Q9Y450	78	143	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
HBS1L	Q9Y450	78	143	127	127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
HBS1L	Q9Y450	78	143	37	78	Alternative sequence	ID=VSP_041068;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HBS1L	Q9Y450	36	78	37	78	Alternative sequence	ID=VSP_041068;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HCFC1	P51610	535	601	2	1423	Chain	ID=PRO_0000016611;Note=HCF N-terminal chain 6
HCFC1	P51610	361	481	2	1423	Chain	ID=PRO_0000016611;Note=HCF N-terminal chain 6
HCFC1	P51610	535	601	2	1323	Chain	ID=PRO_0000016612;Note=HCF N-terminal chain 5
HCFC1	P51610	361	481	2	1323	Chain	ID=PRO_0000016612;Note=HCF N-terminal chain 5
HCFC1	P51610	535	601	2	1295	Chain	ID=PRO_0000016613;Note=HCF N-terminal chain 4
HCFC1	P51610	361	481	2	1295	Chain	ID=PRO_0000016613;Note=HCF N-terminal chain 4
HCFC1	P51610	535	601	2	1110	Chain	ID=PRO_0000016614;Note=HCF N-terminal chain 3
HCFC1	P51610	361	481	2	1110	Chain	ID=PRO_0000016614;Note=HCF N-terminal chain 3
HCFC1	P51610	535	601	2	1081	Chain	ID=PRO_0000016615;Note=HCF N-terminal chain 2
HCFC1	P51610	361	481	2	1081	Chain	ID=PRO_0000016615;Note=HCF N-terminal chain 2
HCFC1	P51610	535	601	2	1019	Chain	ID=PRO_0000016616;Note=HCF N-terminal chain 1
HCFC1	P51610	361	481	2	1019	Chain	ID=PRO_0000016616;Note=HCF N-terminal chain 1
HCFC1	P51610	1839	1901	1020	2035	Chain	ID=PRO_0000016617;Note=HCF C-terminal chain 1
HCFC1	P51610	1839	1901	1082	2035	Chain	ID=PRO_0000016618;Note=HCF C-terminal chain 2
HCFC1	P51610	1839	1901	1111	2035	Chain	ID=PRO_0000016619;Note=HCF C-terminal chain 3
HCFC1	P51610	1839	1901	1296	2035	Chain	ID=PRO_0000016620;Note=HCF C-terminal chain 4
HCFC1	P51610	1839	1901	1324	2035	Chain	ID=PRO_0000016621;Note=HCF C-terminal chain 5
HCFC1	P51610	1839	1901	1424	2035	Chain	ID=PRO_0000016622;Note=HCF C-terminal chain 6
HCFC1	P51610	361	481	366	466	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HCFC1	P51610	1839	1901	1797	1888	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HCFC1	P51610	1839	1901	1890	2006	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HCFC1	P51610	535	601	500	550	Region	Note=Required for interaction with OGT
HCFC1	P51610	361	481	411	411	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
HCFC1	P51610	535	601	598	598	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HCFC1	P51610	361	481	363	363	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19815555;Dbxref=PMID:19815555
HCFC1	P51610	361	481	382	450	Alternative sequence	ID=VSP_002815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8392914;Dbxref=PMID:8392914
HCFC1	P51610	361	481	428	428	Alternative sequence	ID=VSP_012984;Note=In isoform 3. P->L;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HCFC1	P51610	1839	1901	429	2035	Alternative sequence	ID=VSP_012985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HCFC1	P51610	535	601	429	2035	Alternative sequence	ID=VSP_012985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HCFC1	P51610	361	481	429	2035	Alternative sequence	ID=VSP_012985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HCFC1	P51610	535	601	564	564	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HCFC1	P51610	1839	1901	1873	1873	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
HCFC1	P51610	361	481	368	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	361	481	380	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	361	481	391	399	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	1839	1901	1853	1855	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	1839	1901	1861	1870	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	1839	1901	1873	1877	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	1839	1901	1881	1884	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
HCFC1	P51610	1839	1901	1895	1902	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GO6
ALAS1	P13196	388	443	57	640	Chain	ID=PRO_0000001230;Note=5-aminolevulinate synthase%2C nonspecific%2C mitochondrial
ALAS1	P13196	388	443	57	640	Chain	ID=PRO_0000001230;Note=5-aminolevulinate synthase%2C nonspecific%2C mitochondrial
ALAS1	P13196	388	443	57	640	Chain	ID=PRO_0000001230;Note=5-aminolevulinate synthase%2C nonspecific%2C mitochondrial
ALAS1	P13196	388	443	57	640	Chain	ID=PRO_0000001230;Note=5-aminolevulinate synthase%2C nonspecific%2C mitochondrial
ALAS1	P13196	388	443	414	414	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	414	414	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	414	414	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	414	414	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	442	442	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	442	442	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	442	442	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	442	442	Binding site	Note=Pyridoxal phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18079
ALAS1	P13196	388	443	119	640	Alternative sequence	ID=VSP_025924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3671094;Dbxref=PMID:3671094
ALAS1	P13196	388	443	119	640	Alternative sequence	ID=VSP_025924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3671094;Dbxref=PMID:3671094
ALAS1	P13196	388	443	119	640	Alternative sequence	ID=VSP_025924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3671094;Dbxref=PMID:3671094
ALAS1	P13196	388	443	119	640	Alternative sequence	ID=VSP_025924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3671094;Dbxref=PMID:3671094
HELQ	Q8TDG4	983	1021	1	1101	Chain	ID=PRO_0000329060;Note=Helicase POLQ-like
HELQ	Q8TDG4	925	983	1	1101	Chain	ID=PRO_0000329060;Note=Helicase POLQ-like
HELQ	Q8TDG4	892	925	1	1101	Chain	ID=PRO_0000329060;Note=Helicase POLQ-like
HELQ	Q8TDG4	397	464	1	1101	Chain	ID=PRO_0000329060;Note=Helicase POLQ-like
HELQ	Q8TDG4	397	464	346	518	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
HELQ	Q8TDG4	397	464	463	466	Motif	Note=DEAH box
HELQ	Q8TDG4	983	1021	137	1101	Alternative sequence	ID=VSP_032944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HELQ	Q8TDG4	925	983	137	1101	Alternative sequence	ID=VSP_032944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HELQ	Q8TDG4	892	925	137	1101	Alternative sequence	ID=VSP_032944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HELQ	Q8TDG4	397	464	137	1101	Alternative sequence	ID=VSP_032944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HELQ	Q8TDG4	983	1021	354	1101	Alternative sequence	ID=VSP_032948;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
HELQ	Q8TDG4	925	983	354	1101	Alternative sequence	ID=VSP_032948;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
HELQ	Q8TDG4	892	925	354	1101	Alternative sequence	ID=VSP_032948;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
HELQ	Q8TDG4	397	464	354	1101	Alternative sequence	ID=VSP_032948;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
GPSM2	P81274	266	317	1	684	Chain	ID=PRO_0000106358;Note=G-protein-signaling modulator 2
GPSM2	P81274	421	480	1	684	Chain	ID=PRO_0000106358;Note=G-protein-signaling modulator 2
GPSM2	P81274	266	317	1	684	Chain	ID=PRO_0000106358;Note=G-protein-signaling modulator 2
GPSM2	P81274	421	480	1	684	Chain	ID=PRO_0000106358;Note=G-protein-signaling modulator 2
GPSM2	P81274	266	317	242	275	Repeat	Note=TPR 6
GPSM2	P81274	266	317	242	275	Repeat	Note=TPR 6
GPSM2	P81274	266	317	282	315	Repeat	Note=TPR 7
GPSM2	P81274	266	317	282	315	Repeat	Note=TPR 7
GPSM2	P81274	266	317	22	357	Region	Note=Important for interaction with NUMA1%3B INSC and FRMPD1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDU0
GPSM2	P81274	266	317	22	357	Region	Note=Important for interaction with NUMA1%3B INSC and FRMPD1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDU0
GPSM2	P81274	266	317	290	290	Mutagenesis	Note=Abolishes interaction with INSC%3B when associated with E-228. N->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22074847;Dbxref=PMID:22074847
GPSM2	P81274	266	317	290	290	Mutagenesis	Note=Abolishes interaction with INSC%3B when associated with E-228. N->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22074847;Dbxref=PMID:22074847
GPSM2	P81274	266	317	258	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WND
GPSM2	P81274	266	317	258	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WND
GPSM2	P81274	266	317	278	294	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WND
GPSM2	P81274	266	317	278	294	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WND
GPSM2	P81274	266	317	298	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WND
GPSM2	P81274	266	317	298	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WND
GZMH	P20718	113	199	21	246	Chain	ID=PRO_0000027414;Note=Granzyme H
GZMH	P20718	113	199	21	244	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
GZMH	P20718	113	199	179	179	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GZMH	P20718	113	199	142	208	Disulfide bond	.
GZMH	P20718	113	199	172	187	Disulfide bond	.
GZMH	P20718	113	199	69	199	Alternative sequence	ID=VSP_047573;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GZMH	P20718	113	199	114	199	Alternative sequence	ID=VSP_047073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GZMH	P20718	113	199	110	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GAW
GZMH	P20718	113	199	141	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	160	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	169	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	182	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	185	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GZMH	P20718	113	199	199	203	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TK9
GPATCH8	Q9UKJ3	116	164	1	1502	Chain	ID=PRO_0000050761;Note=G patch domain-containing protein 8
GPATCH8	Q9UKJ3	15	40	1	1502	Chain	ID=PRO_0000050761;Note=G patch domain-containing protein 8
GPATCH8	Q9UKJ3	15	40	40	86	Domain	Note=G-patch;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00092
GPATCH8	Q9UKJ3	116	164	136	160	Zinc finger	Note=C2H2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GPATCH8	Q9UKJ3	116	164	89	124	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GPATCH8	Q9UKJ3	15	40	1	78	Alternative sequence	ID=VSP_037683;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9628581;Dbxref=PMID:9628581
GPATCH8	Q9UKJ3	116	164	44	1502	Alternative sequence	ID=VSP_037685;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GRIA1	P42261	73	153	19	906	Chain	ID=PRO_0000011529;Note=Glutamate receptor 1
GRIA1	P42261	73	153	19	536	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA1	P42261	73	153	75	323	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA1	P42261	73	153	74	154	Alternative sequence	ID=VSP_045120;Note=In isoform 3. FCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIIDHYKWQKFVYIYDADRG->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPAGT1	Q9H3H5	243	305	1	408	Chain	ID=PRO_0000108761;Note=UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
DPAGT1	Q9H3H5	243	305	1	408	Chain	ID=PRO_0000108761;Note=UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
DPAGT1	Q9H3H5	243	305	243	250	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	243	250	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	251	269	Transmembrane	Note=Helical%3B Name%3DHelix 8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	251	269	Transmembrane	Note=Helical%3B Name%3DHelix 8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	270	271	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	270	271	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	272	293	Transmembrane	Note=Helical%3B Name%3DHelix 9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	272	293	Transmembrane	Note=Helical%3B Name%3DHelix 9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	294	375	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	294	375	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	252	252	Binding site	Note=Inhibitor;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BW5,ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	252	252	Binding site	Note=Inhibitor;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BW5,ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	303	303	Binding site	Note=Inhibitor;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BW5,ECO:0000244|PDB:6BW6,ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	303	303	Binding site	Note=Inhibitor;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BW5,ECO:0000244|PDB:6BW6,ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	264	264	Natural variant	ID=VAR_068815;Note=In CMS13. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22742743;Dbxref=dbSNP:rs387907245,PMID:22742743
DPAGT1	Q9H3H5	243	305	264	264	Natural variant	ID=VAR_068815;Note=In CMS13. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22742743;Dbxref=dbSNP:rs387907245,PMID:22742743
DPAGT1	Q9H3H5	243	305	252	252	Mutagenesis	Note=Reduces binding to inhibitor. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	252	252	Mutagenesis	Note=Reduces binding to inhibitor. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785
DPAGT1	Q9H3H5	243	305	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	251	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	251	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	272	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	272	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	280	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	280	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	290	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
DPAGT1	Q9H3H5	243	305	290	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BW6
GSTK1	Q9Y2Q3	51	94	1	226	Chain	ID=PRO_0000185891;Note=Glutathione S-transferase kappa 1
GSTK1	Q9Y2Q3	128	140	1	226	Chain	ID=PRO_0000185891;Note=Glutathione S-transferase kappa 1
GSTK1	Q9Y2Q3	140	179	1	226	Chain	ID=PRO_0000185891;Note=Glutathione S-transferase kappa 1
GSTK1	Q9Y2Q3	51	94	53	53	Binding site	Note=Glutathione;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16081649;Dbxref=PMID:16081649
GSTK1	Q9Y2Q3	51	94	71	71	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GSTK1	Q9Y2Q3	51	94	85	85	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM2
GSTK1	Q9Y2Q3	140	179	144	144	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM2
GSTK1	Q9Y2Q3	140	179	158	158	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM2
GSTK1	Q9Y2Q3	140	179	158	158	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM2
GSTK1	Q9Y2Q3	140	179	165	165	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM2
GSTK1	Q9Y2Q3	140	179	169	169	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GSTK1	Q9Y2Q3	51	94	52	94	Alternative sequence	ID=VSP_040978;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GSTK1	Q9Y2Q3	128	140	128	128	Alternative sequence	ID=VSP_040025;Note=In isoform 2. R->RVSVGLWESSGRTLDDFLTFPRHVFRVMILPPPGGSTVLPVTPLSPHRLPAVFSSSQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
GSTK1	Q9Y2Q3	128	140	129	140	Alternative sequence	ID=VSP_040979;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GSTK1	Q9Y2Q3	140	179	129	140	Alternative sequence	ID=VSP_040979;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GSTK1	Q9Y2Q3	51	94	51	51	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GSTK1	Q9Y2Q3	140	179	171	171	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
GSTK1	Q9Y2Q3	140	179	179	179	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GSTK1	Q9Y2Q3	51	94	57	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	51	94	61	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	51	94	88	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	128	140	135	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	140	179	135	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	140	179	149	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	140	179	157	160	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
GSTK1	Q9Y2Q3	140	179	162	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RPP
EIF4A1	P60842	208	256	2	406	Chain	ID=PRO_0000054933;Note=Eukaryotic initiation factor 4A-I
EIF4A1	P60842	256	302	2	406	Chain	ID=PRO_0000054933;Note=Eukaryotic initiation factor 4A-I
EIF4A1	P60842	208	256	63	234	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A1	P60842	208	256	245	406	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A1	P60842	256	302	245	406	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A1	P60842	208	256	238	238	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60843
EIF4A1	P60842	208	256	225	225	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EIF4A1	P60842	208	256	238	238	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EIF4A1	P60842	208	256	208	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9N
EIF4A1	P60842	208	256	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9N
EIF4A1	P60842	208	256	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EIQ
EIF4A1	P60842	208	256	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9N
EIF4A1	P60842	208	256	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	208	256	246	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	208	256	256	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	256	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	273	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	282	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	291	296	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	300	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EIQ
GMPS	P49915	346	404	2	693	Chain	ID=PRO_0000140257;Note=GMP synthase [glutamine-hydrolyzing]
GMPS	P49915	346	404	217	435	Domain	Note=GMPS ATP-PPase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00886
GMPS	P49915	346	404	333	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXO
GMPS	P49915	346	404	361	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXO
GMPS	P49915	346	404	377	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXO
GMPS	P49915	346	404	387	389	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXO
GMPS	P49915	346	404	396	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXO
EIF4B	P23588	120	159	1	611	Chain	ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B
EIF4B	P23588	177	222	1	611	Chain	ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B
EIF4B	P23588	222	268	1	611	Chain	ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B
EIF4B	P23588	120	159	96	173	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
EIF4B	P23588	177	222	164	331	Compositional bias	Note=Arg-rich
EIF4B	P23588	222	268	164	331	Compositional bias	Note=Arg-rich
EIF4B	P23588	177	222	169	325	Compositional bias	Note=Asp-rich
EIF4B	P23588	222	268	169	325	Compositional bias	Note=Asp-rich
EIF4B	P23588	177	222	192	192	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EIF4B	P23588	177	222	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EIF4B	P23588	177	222	219	219	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
EIF4B	P23588	120	159	121	159	Alternative sequence	ID=VSP_057351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EIF4B	P23588	177	222	203	203	Natural variant	ID=VAR_064710;Note=Found in a renal cell carcinoma case%3B somatic mutation. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752
EIF4B	P23588	222	268	246	246	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4B	P23588	120	159	121	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4B	P23588	120	159	130	133	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J76
EIF4B	P23588	120	159	140	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4B	P23588	120	159	147	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4B	P23588	120	159	155	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
GXYLT1	Q4G148	204	288	1	440	Chain	ID=PRO_0000288534;Note=Glucoside xylosyltransferase 1
GXYLT1	Q4G148	204	288	30	440	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GXYLT1	Q4G148	204	288	237	237	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GXYLT1	Q4G148	204	288	278	278	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
GXYLT1	Q4G148	204	288	211	211	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
HACL1	Q9UJ83	331	365	1	578	Chain	ID=PRO_0000090816;Note=2-hydroxyacyl-CoA lyase 1
HACL1	Q9UJ83	303	331	1	578	Chain	ID=PRO_0000090816;Note=2-hydroxyacyl-CoA lyase 1
HACL1	Q9UJ83	127	153	1	578	Chain	ID=PRO_0000090816;Note=2-hydroxyacyl-CoA lyase 1
HACL1	Q9UJ83	76	102	1	578	Chain	ID=PRO_0000090816;Note=2-hydroxyacyl-CoA lyase 1
HACL1	Q9UJ83	331	365	351	351	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXE0
HACL1	Q9UJ83	331	365	358	358	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXE0
HACL1	Q9UJ83	331	365	365	365	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXE0
HACL1	Q9UJ83	76	102	77	103	Alternative sequence	ID=VSP_054191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HACL1	Q9UJ83	127	153	104	185	Alternative sequence	ID=VSP_054192;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HACL1	Q9UJ83	127	153	128	153	Alternative sequence	ID=VSP_054749;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HACL1	Q9UJ83	331	365	332	365	Alternative sequence	ID=VSP_054750;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ISOC2	Q96AB3	46	116	1	205	Chain	ID=PRO_0000268671;Note=Isochorismatase domain-containing protein 2
ISOC2	Q96AB3	46	116	47	116	Alternative sequence	ID=VSP_038741;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ISOC2	Q96AB3	46	116	116	116	Alternative sequence	ID=VSP_022000;Note=In isoform 2. L->LDPRSYPGLALTSLYPQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
HEATR1	Q9H583	1316	1359	1	2144	Chain	ID=PRO_0000424485;Note=HEAT repeat-containing protein 1
HEATR1	Q9H583	1028	1109	1	2144	Chain	ID=PRO_0000424485;Note=HEAT repeat-containing protein 1
HEATR1	Q9H583	1316	1359	2	2144	Chain	ID=PRO_0000186201;Note=HEAT repeat-containing protein 1%2C N-terminally processed
HEATR1	Q9H583	1028	1109	2	2144	Chain	ID=PRO_0000186201;Note=HEAT repeat-containing protein 1%2C N-terminally processed
HIGD1B	Q9P298	33	78	1	99	Chain	ID=PRO_0000215774;Note=HIG1 domain family member 1B
HIGD1B	Q9P298	33	78	1	99	Chain	ID=PRO_0000215774;Note=HIG1 domain family member 1B
HIGD1B	Q9P298	33	78	30	47	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00836
HIGD1B	Q9P298	33	78	30	47	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00836
HIGD1B	Q9P298	33	78	48	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HIGD1B	Q9P298	33	78	48	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HIGD1B	Q9P298	33	78	62	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00836
HIGD1B	Q9P298	33	78	62	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00836
HIGD1B	Q9P298	33	78	1	94	Domain	Note=HIG1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00836
HIGD1B	Q9P298	33	78	1	94	Domain	Note=HIG1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00836
HIGD1B	Q9P298	33	78	30	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LON
HIGD1B	Q9P298	33	78	30	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LON
HIGD1B	Q9P298	33	78	66	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LON
HIGD1B	Q9P298	33	78	66	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LON
GNAS	Q5JWF2	71	85	1	1037	Chain	ID=PRO_0000253984;Note=Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
GNAS	Q5JWF2	104	144	1	1037	Chain	ID=PRO_0000253984;Note=Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
GNAS	Q5JWF2	714	728	1	1037	Chain	ID=PRO_0000253984;Note=Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
GNAS	Q5JWF2	747	787	1	1037	Chain	ID=PRO_0000253984;Note=Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
GNAS	Q5JWF2	747	787	730	756	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GNAS	Q5JWF2	714	728	691	752	Alternative sequence	ID=VSP_052173;Note=In isoform XLas-3. AGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAA->RKVVPSDTEGRFRLDRPAPATVSWTGRGFSVSSLLIRSPNPPAFTVEKPDTQVLENLVKAPL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9707596;Dbxref=PMID:9707596
GNAS	Q5JWF2	747	787	691	752	Alternative sequence	ID=VSP_052173;Note=In isoform XLas-3. AGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAA->RKVVPSDTEGRFRLDRPAPATVSWTGRGFSVSSLLIRSPNPPAFTVEKPDTQVLENLVKAPL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9707596;Dbxref=PMID:9707596
GNAS	Q5JWF2	714	728	714	729	Alternative sequence	ID=VSP_052174;Note=In isoform XLas-2. EGGEEDPQAARSNSDG->DS;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNAS	Q5JWF2	747	787	753	1037	Alternative sequence	ID=VSP_052175;Note=In isoform XLas-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9707596;Dbxref=PMID:9707596
GNAS	Q5JWF2	104	144	132	132	Sequence conflict	Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNS	P15586	400	436	37	552	Chain	ID=PRO_0000033413;Note=N-acetylglucosamine-6-sulfatase
GNS	P15586	366	400	37	552	Chain	ID=PRO_0000033413;Note=N-acetylglucosamine-6-sulfatase
GNS	P15586	208	264	37	552	Chain	ID=PRO_0000033413;Note=N-acetylglucosamine-6-sulfatase
GNS	P15586	64	84	37	552	Chain	ID=PRO_0000033413;Note=N-acetylglucosamine-6-sulfatase
GNS	P15586	208	264	210	210	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GNS	P15586	366	400	387	387	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GNS	P15586	400	436	405	405	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GNS	P15586	400	436	422	422	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1463457,ECO:0000269|PubMed:19159218;Dbxref=PMID:1463457,PMID:19159218
GNS	P15586	64	84	65	84	Alternative sequence	ID=VSP_056486;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNS	P15586	400	436	418	418	Natural variant	ID=VAR_064073;Note=In MPS3D. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20232353;Dbxref=PMID:20232353
GNS	P15586	208	264	252	252	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNB1L	Q9BYB4	139	172	1	327	Chain	ID=PRO_0000051008;Note=Guanine nucleotide-binding protein subunit beta-like protein 1
GNB1L	Q9BYB4	43	84	1	327	Chain	ID=PRO_0000051008;Note=Guanine nucleotide-binding protein subunit beta-like protein 1
GNB1L	Q9BYB4	139	172	1	327	Chain	ID=PRO_0000051008;Note=Guanine nucleotide-binding protein subunit beta-like protein 1
GNB1L	Q9BYB4	43	84	1	327	Chain	ID=PRO_0000051008;Note=Guanine nucleotide-binding protein subunit beta-like protein 1
GNB1L	Q9BYB4	43	84	16	54	Repeat	Note=WD 1
GNB1L	Q9BYB4	43	84	16	54	Repeat	Note=WD 1
GNB1L	Q9BYB4	43	84	58	97	Repeat	Note=WD 2
GNB1L	Q9BYB4	43	84	58	97	Repeat	Note=WD 2
GNB1L	Q9BYB4	139	172	103	145	Repeat	Note=WD 3
GNB1L	Q9BYB4	139	172	103	145	Repeat	Note=WD 3
GNB1L	Q9BYB4	139	172	153	195	Repeat	Note=WD 4
GNB1L	Q9BYB4	139	172	153	195	Repeat	Note=WD 4
GNPTG	Q9UJJ9	203	247	25	305	Chain	ID=PRO_0000019577;Note=N-acetylglucosamine-1-phosphotransferase subunit gamma
GNPTG	Q9UJJ9	203	247	245	245	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNPTG	Q9UJJ9	203	247	230	230	Natural variant	ID=VAR_073224;Note=Rare variant%3B found in individuals suffering from stuttering%3B unknown pathological significance. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20147709;Dbxref=dbSNP:rs137853827,PMID:20147709
GNPTG	Q9UJJ9	203	247	223	223	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPATCH2L	Q9NWQ4	242	301	1	482	Chain	ID=PRO_0000089927;Note=G patch domain-containing protein 2-like
GPATCH2L	Q9NWQ4	242	301	1	482	Chain	ID=PRO_0000089927;Note=G patch domain-containing protein 2-like
GRHPR	Q9UBQ7	96	134	1	328	Chain	ID=PRO_0000075944;Note=Glyoxylate reductase/hydroxypyruvate reductase
GRHPR	Q9UBQ7	164	199	1	328	Chain	ID=PRO_0000075944;Note=Glyoxylate reductase/hydroxypyruvate reductase
GRHPR	Q9UBQ7	164	199	162	164	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16756993;Dbxref=PMID:16756993
GRHPR	Q9UBQ7	164	199	185	188	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16756993;Dbxref=PMID:16756993
GRHPR	Q9UBQ7	96	134	22	164	Alternative sequence	ID=VSP_057017;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRHPR	Q9UBQ7	164	199	22	164	Alternative sequence	ID=VSP_057017;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRHPR	Q9UBQ7	164	199	170	170	Natural variant	ID=VAR_032762;Note=R->Q;Dbxref=dbSNP:rs12002324
GRHPR	Q9UBQ7	96	134	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	96	134	108	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	96	134	126	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	164	199	163	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	164	199	173	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	164	199	179	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	164	199	189	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	164	199	194	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GCG
GRHPR	Q9UBQ7	164	199	197	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q50
EIF4E	P06730	95	133	2	217	Chain	ID=PRO_0000193634;Note=Eukaryotic translation initiation factor 4E
EIF4E	P06730	42	73	2	217	Chain	ID=PRO_0000193634;Note=Eukaryotic translation initiation factor 4E
EIF4E	P06730	42	73	56	57	Region	Note=7-methylguanosine-containing mRNA cap binding
EIF4E	P06730	42	73	73	77	Region	Note=EIF4EBP1/2/3 binding
EIF4E	P06730	95	133	102	103	Region	Note=7-methylguanosine-containing mRNA cap binding
EIF4E	P06730	95	133	132	139	Region	Note=EIF4EBP1/2/3 binding
EIF4E	P06730	95	133	133	133	Alternative sequence	ID=VSP_042014;Note=In isoform 2. T->TRWDLAMLPRLVSNFWPQVILPLQPPKVLELQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16341674;Dbxref=PMID:16341674
EIF4E	P06730	42	73	53	53	Mutagenesis	Note=No effect on phosphorylation level nor incorporation into eIF4F complex. S->A%2CD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7590282,ECO:0000269|PubMed:8505316;Dbxref=PMID:7590282,PMID:8505316
EIF4E	P06730	42	73	73	73	Mutagenesis	Note=Abolishes binding to EIF4EBP1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22578813;Dbxref=PMID:22578813
EIF4E	P06730	95	133	102	102	Mutagenesis	Note=Decrease in mRNA cap binding%3B when associated with A-105. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	103	103	Mutagenesis	Note=No effect. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	104	104	Mutagenesis	Note=No effect. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	105	105	Mutagenesis	Note=Decrease in mRNA cap binding%3B when associated with L-102. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	119	119	Mutagenesis	Note=Higher affinity for EIF4G1. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17036047;Dbxref=PMID:17036047
EIF4E	P06730	95	133	127	127	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4E	P06730	42	73	38	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	42	73	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW6
EIF4E	P06730	42	73	56	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	42	73	60	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	42	73	69	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	89	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	100	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GPQ
EIF4E	P06730	95	133	105	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	111	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	119	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	123	125	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	126	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4G3	O43432	1476	1525	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	1400	1449	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	1367	1400	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	946	981	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	695	752	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	218	498	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	10	70	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	695	752	745	783	Repeat	Note=HEAT 1
EIF4G3	O43432	946	981	755	983	Domain	Note=MIF4G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
EIF4G3	O43432	946	981	945	984	Repeat	Note=HEAT 5
EIF4G3	O43432	1476	1525	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF4G3	O43432	1400	1449	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF4G3	O43432	946	981	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	695	752	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	1476	1525	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	1400	1449	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	218	498	447	475	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF4G3	O43432	695	752	699	700	Site	Note=Cleavage%3B by enterovirus/rhinovirus protease 2A
EIF4G3	O43432	695	752	700	701	Site	Note=Cleavage%3B by foot-and-mouth disease virus leader protease
EIF4G3	O43432	218	498	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
EIF4G3	O43432	218	498	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EIF4G3	O43432	218	498	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
EIF4G3	O43432	218	498	441	441	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80XI3
EIF4G3	O43432	218	498	495	495	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17693683,PMID:18088087,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EIF4G3	O43432	1400	1449	1409	1409	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EIF4G3	O43432	10	70	10	10	Alternative sequence	ID=VSP_043447;Note=In isoform 3. P->PGGFRPIQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	10	70	11	11	Alternative sequence	ID=VSP_010487;Note=In isoform 2. F->FAAGPRPPHHQF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	218	498	219	498	Alternative sequence	ID=VSP_054502;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	1476	1525	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	1400	1449	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	1367	1400	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	946	981	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	695	752	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	218	498	378	378	Natural variant	ID=VAR_048924;Note=Q->R;Dbxref=dbSNP:rs35731992
EIF4G3	O43432	218	498	496	496	Natural variant	ID=VAR_034009;Note=P->A;Dbxref=dbSNP:rs35176330
EIF4G3	O43432	218	498	333	333	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4G3	O43432	695	752	746	762	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HU3
EIF4G3	O43432	946	981	946	961	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HU3
EIF4G3	O43432	946	981	967	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HU3
MASTL	Q96GX5	62	108	1	879	Chain	ID=PRO_0000086315;Note=Serine/threonine-protein kinase greatwall
MASTL	Q96GX5	755	793	1	879	Chain	ID=PRO_0000086315;Note=Serine/threonine-protein kinase greatwall
MASTL	Q96GX5	793	827	1	879	Chain	ID=PRO_0000086315;Note=Serine/threonine-protein kinase greatwall
MASTL	Q96GX5	62	108	35	835	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MASTL	Q96GX5	755	793	35	835	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MASTL	Q96GX5	793	827	35	835	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MASTL	Q96GX5	62	108	62	62	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MASTL	Q96GX5	755	793	756	793	Alternative sequence	ID=VSP_014575;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MASTL	Q96GX5	793	827	756	793	Alternative sequence	ID=VSP_014575;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MASTL	Q96GX5	62	108	72	72	Mutagenesis	Note=Hyperactive form. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21164014;Dbxref=PMID:21164014
MASTL	Q96GX5	62	108	58	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LOH
MASTL	Q96GX5	62	108	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LOH
MASTL	Q96GX5	62	108	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LOH
MASTL	Q96GX5	62	108	103	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LOH
HADH	Q16836	44	87	13	314	Chain	ID=PRO_0000007406;Note=Hydroxyacyl-coenzyme A dehydrogenase%2C mitochondrial
HADH	Q16836	182	212	13	314	Chain	ID=PRO_0000007406;Note=Hydroxyacyl-coenzyme A dehydrogenase%2C mitochondrial
HADH	Q16836	44	87	57	57	Binding site	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10231530,ECO:0000269|PubMed:10840044;Dbxref=PMID:10231530,PMID:10840044
HADH	Q16836	44	87	73	73	Binding site	Note=Coenzyme A
HADH	Q16836	44	87	80	80	Binding site	Note=Coenzyme A
HADH	Q16836	44	87	80	80	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	44	87	81	81	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	44	87	81	81	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	44	87	87	87	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	44	87	87	87	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	185	185	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HADH	Q16836	182	212	185	185	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	192	192	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	192	192	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	202	202	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HADH	Q16836	182	212	202	202	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	206	206	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	212	212	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	182	212	212	212	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61425
HADH	Q16836	44	87	57	57	Natural variant	ID=VAR_024080;Note=In HADH deficiency. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.13;Dbxref=dbSNP:rs137853102
HADH	Q16836	44	87	86	86	Natural variant	ID=VAR_026764;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8687463,ECO:0000269|Ref.2,ECO:0000269|Ref.3;Dbxref=dbSNP:rs4956145,PMID:15489334,PMID:8687463
HADH	Q16836	44	87	37	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	44	87	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	44	87	60	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	44	87	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	44	87	86	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	182	212	180	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	182	212	191	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HADH	Q16836	182	212	207	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F0Y
HCFC2	Q9Y5Z7	354	410	1	792	Chain	ID=PRO_0000119072;Note=Host cell factor 2
HCFC2	Q9Y5Z7	626	688	1	792	Chain	ID=PRO_0000119072;Note=Host cell factor 2
HCFC2	Q9Y5Z7	354	410	359	449	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HCFC2	Q9Y5Z7	626	688	583	675	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HCFC2	Q9Y5Z7	626	688	677	787	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HCFC2	Q9Y5Z7	626	688	413	792	Alternative sequence	ID=VSP_057025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HTT	P42858	156	176	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	424	440	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	933	981	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	1415	1469	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	1583	1622	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	1622	1663	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	1906	1966	1	3142	Chain	ID=PRO_0000083942;Note=Huntingtin
HTT	P42858	933	981	902	940	Repeat	Note=HEAT 5
HTT	P42858	1415	1469	1437	1440	Compositional bias	Note=Poly-Thr
HTT	P42858	156	176	176	176	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21685499;Dbxref=PMID:21685499
HTT	P42858	424	440	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:24275569
GLRX3	O76003	67	92	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
GLRX3	O76003	288	319	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
GLRX3	O76003	67	92	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
GLRX3	O76003	288	319	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
GLRX3	O76003	67	92	2	117	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
GLRX3	O76003	67	92	2	117	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
GLRX3	O76003	288	319	237	335	Domain	Note=Glutaredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00686
GLRX3	O76003	288	319	237	335	Domain	Note=Glutaredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00686
GLRX3	O76003	288	319	299	300	Mutagenesis	Note=Loss of 2Fe-2S-binding and interaction with BOLA2%3B when associated with S-261. WP->DA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27519415;Dbxref=PMID:27519415
GLRX3	O76003	288	319	299	300	Mutagenesis	Note=Loss of 2Fe-2S-binding and interaction with BOLA2%3B when associated with S-261. WP->DA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27519415;Dbxref=PMID:27519415
GLRX3	O76003	67	92	67	67	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLRX3	O76003	67	92	67	67	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLRX3	O76003	67	92	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	74	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	74	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	84	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	67	92	84	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZ9
GLRX3	O76003	288	319	287	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	287	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	304	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	304	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GLRX3	O76003	288	319	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAN
GMCL1	Q96IK5	231	252	1	515	Chain	ID=PRO_0000087520;Note=Germ cell-less protein-like 1
GMCL1	Q96IK5	311	357	1	515	Chain	ID=PRO_0000087520;Note=Germ cell-less protein-like 1
GMCL1	Q96IK5	311	357	325	325	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG2	O15488	2	33	1	501	Chain	ID=PRO_0000215180;Note=Glycogenin-2
GYG2	O15488	412	448	1	501	Chain	ID=PRO_0000215180;Note=Glycogenin-2
GYG2	O15488	2	33	3	42	Alternative sequence	ID=VSP_001771;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG2	O15488	2	33	3	33	Alternative sequence	ID=VSP_001770;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GYG2	O15488	412	448	378	448	Alternative sequence	ID=VSP_001772;Note=In isoform Delta. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG2	O15488	412	448	407	501	Alternative sequence	ID=VSP_001773;Note=In isoform Epsilon. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG2	O15488	412	448	413	448	Alternative sequence	ID=VSP_001774;Note=In isoform Zeta. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG2	O15488	2	33	7	7	Natural variant	ID=VAR_053110;Note=H->Y;Dbxref=dbSNP:rs11797037
GYG2	O15488	412	448	413	413	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNPDA1	P46926	41	75	1	289	Chain	ID=PRO_0000160122;Note=Glucosamine-6-phosphate isomerase 1
GNPDA1	P46926	41	75	1	289	Chain	ID=PRO_0000160122;Note=Glucosamine-6-phosphate isomerase 1
GNPDA1	P46926	41	75	1	289	Chain	ID=PRO_0000160122;Note=Glucosamine-6-phosphate isomerase 1
GNPDA1	P46926	41	75	1	289	Chain	ID=PRO_0000160122;Note=Glucosamine-6-phosphate isomerase 1
GNPDA1	P46926	41	75	72	72	Active site	Note=Proton acceptor%3B for enolization step;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNPDA1	P46926	41	75	72	72	Active site	Note=Proton acceptor%3B for enolization step;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNPDA1	P46926	41	75	72	72	Active site	Note=Proton acceptor%3B for enolization step;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNPDA1	P46926	41	75	72	72	Active site	Note=Proton acceptor%3B for enolization step;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNPDA1	P46926	41	75	64	64	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GNPDA1	P46926	41	75	64	64	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GNPDA1	P46926	41	75	64	64	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GNPDA1	P46926	41	75	64	64	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GNPDA1	P46926	41	75	69	145	Alternative sequence	ID=VSP_057011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNPDA1	P46926	41	75	69	145	Alternative sequence	ID=VSP_057011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNPDA1	P46926	41	75	69	145	Alternative sequence	ID=VSP_057011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNPDA1	P46926	41	75	69	145	Alternative sequence	ID=VSP_057011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNPDA1	P46926	41	75	43	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	43	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	43	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	43	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	66	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	66	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	66	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA1	P46926	41	75	66	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NE7
GNPDA2	Q8TDQ7	41	75	1	276	Chain	ID=PRO_0000343205;Note=Glucosamine-6-phosphate isomerase 2
GNPDA2	Q8TDQ7	41	75	72	72	Active site	Note=Proton acceptor%3B for enolization step;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNPDA2	Q8TDQ7	41	75	1	70	Alternative sequence	ID=VSP_047033;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNPDA2	Q8TDQ7	41	75	43	76	Alternative sequence	ID=VSP_047034;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
GORASP1	Q9BQQ3	305	356	2	440	Chain	ID=PRO_0000087570;Note=Golgi reassembly-stacking protein 1
GORASP1	Q9BQQ3	48	116	2	440	Chain	ID=PRO_0000087570;Note=Golgi reassembly-stacking protein 1
GORASP1	Q9BQQ3	21	48	2	440	Chain	ID=PRO_0000087570;Note=Golgi reassembly-stacking protein 1
GORASP1	Q9BQQ3	48	116	15	105	Domain	Note=PDZ GRASP-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01212
GORASP1	Q9BQQ3	21	48	15	105	Domain	Note=PDZ GRASP-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01212
GORASP1	Q9BQQ3	48	116	111	199	Domain	Note=PDZ GRASP-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01212
GORASP1	Q9BQQ3	48	116	15	215	Region	Note=GRASP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01214
GORASP1	Q9BQQ3	21	48	15	215	Region	Note=GRASP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01214
GORASP1	Q9BQQ3	305	356	348	352	Compositional bias	Note=Poly-Ser
GORASP1	Q9BQQ3	48	116	103	103	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35254
GORASP1	Q9BQQ3	48	116	1	73	Alternative sequence	ID=VSP_011306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GORASP1	Q9BQQ3	21	48	1	73	Alternative sequence	ID=VSP_011306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GORASP1	Q9BQQ3	305	356	176	440	Alternative sequence	ID=VSP_011307;Note=In isoform 2. VTVTPNAAWGGEGSLGCGIGYGYLHRIPTQPPSYHKKPPGTPPPSALPLGAPPPDALPPGPTPEDSPSLETGSRQSDYMEALLQAPGSSMEDPLPGPGSPSHSAPDPDGLPHFMETPLQPPPPVQRVMDPGFLDVSGISLLDNSNASVWPSLPSSTELTTTAVSTSGPEDICSSSSSHERGGEATWSGSEFEVSFLDSPGAQAQADHLPQLTLPDSLTSAASPEDGLSAELLEAQAEEEPASTEGLDTGTEAEGLDSQAQISTTE->SGMWHWLWVSTPDPNSAPQLPQEATWHPTTFCSTTWCPTT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GORASP1	Q9BQQ3	305	356	306	319	Alternative sequence	ID=VSP_011308;Note=In isoform 3. GFLDVSGISLLDNS->AMPVCGPACPLPQN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GORASP1	Q9BQQ3	305	356	320	440	Alternative sequence	ID=VSP_011309;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GORASP1	Q9BQQ3	21	48	14	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	21	48	27	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	21	48	35	37	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	21	48	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	50	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	54	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	62	64	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	67	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	74	77	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	90	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	98	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP1	Q9BQQ3	48	116	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4REY
GORASP2	Q9H8Y8	21	48	2	452	Chain	ID=PRO_0000087545;Note=Golgi reassembly-stacking protein 2
GORASP2	Q9H8Y8	116	145	2	452	Chain	ID=PRO_0000087545;Note=Golgi reassembly-stacking protein 2
GORASP2	Q9H8Y8	274	303	2	452	Chain	ID=PRO_0000087545;Note=Golgi reassembly-stacking protein 2
GORASP2	Q9H8Y8	21	48	15	105	Domain	Note=PDZ GRASP-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01212
GORASP2	Q9H8Y8	116	145	111	199	Domain	Note=PDZ GRASP-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01212
GORASP2	Q9H8Y8	21	48	15	215	Region	Note=GRASP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01214
GORASP2	Q9H8Y8	116	145	15	215	Region	Note=GRASP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01214
GORASP2	Q9H8Y8	274	303	277	372	Compositional bias	Note=Pro-rich
GORASP2	Q9H8Y8	21	48	30	30	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R064
GORASP2	Q9H8Y8	21	48	30	30	Modified residue	Note=Omega-N-methylated arginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GORASP2	Q9H8Y8	21	48	47	47	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R064
GORASP2	Q9H8Y8	21	48	47	47	Modified residue	Note=Omega-N-methylated arginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GORASP2	Q9H8Y8	21	48	1	68	Alternative sequence	ID=VSP_011300;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GORASP2	Q9H8Y8	21	48	1	21	Alternative sequence	ID=VSP_054364;Note=In isoform 3. MGSSQSVEIPGGGTEGYHVLR->MREGSSTLSEIRKLKPGIMVCTCNPSYSNQETE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GORASP2	Q9H8Y8	21	48	34	34	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
GORASP2	Q9H8Y8	274	303	299	299	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GORASP2	Q9H8Y8	21	48	12	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	21	48	27	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	21	48	35	37	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	21	48	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	116	145	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	116	145	123	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	116	145	131	133	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	116	145	134	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GORASP2	Q9H8Y8	116	145	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RLE
GP2	P55259	31	178	29	512	Chain	ID=PRO_0000041657;Note=Pancreatic secretory granule membrane major glycoprotein GP2
GP2	P55259	31	178	65	65	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GP2	P55259	31	178	122	122	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GP2	P55259	31	178	31	180	Alternative sequence	ID=VSP_035749;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10760606;Dbxref=PMID:10760606
GP2	P55259	31	178	32	178	Alternative sequence	ID=VSP_006948;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
GPBP1L1	Q9HC44	295	348	1	474	Chain	ID=PRO_0000324115;Note=Vasculin-like protein 1
GPBP1L1	Q9HC44	248	295	1	474	Chain	ID=PRO_0000324115;Note=Vasculin-like protein 1
GPBP1L1	Q9HC44	295	348	1	474	Chain	ID=PRO_0000324115;Note=Vasculin-like protein 1
GPBP1L1	Q9HC44	248	295	1	474	Chain	ID=PRO_0000324115;Note=Vasculin-like protein 1
GPBP1L1	Q9HC44	248	295	292	292	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6NZP2
GPBP1L1	Q9HC44	248	295	292	292	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6NZP2
GPBP1L1	Q9HC44	295	348	301	301	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GPBP1L1	Q9HC44	295	348	301	301	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GPBP1L1	Q9HC44	295	348	306	306	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPBP1L1	Q9HC44	295	348	306	306	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPD2	P43304	492	536	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	536	589	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	653	686	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	492	536	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	536	589	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	653	686	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	492	536	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	536	589	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	653	686	43	727	Chain	ID=PRO_0000010429;Note=Glycerol-3-phosphate dehydrogenase%2C mitochondrial
GPD2	P43304	653	686	623	658	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	623	658	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	623	658	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	659	694	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	659	694	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	659	694	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	672	683	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	672	683	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	653	686	672	683	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
GPD2	P43304	492	536	525	525	Natural variant	ID=VAR_025215;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7821823,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1051916,PMID:7821823
GPD2	P43304	492	536	525	525	Natural variant	ID=VAR_025215;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7821823,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1051916,PMID:7821823
GPD2	P43304	492	536	525	525	Natural variant	ID=VAR_025215;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7821823,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1051916,PMID:7821823
PIGK	Q92643	234	271	28	395	Chain	ID=PRO_0000026529;Note=GPI-anchor transamidase
PIGK	Q92643	234	271	28	367	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GMEB1	Q9Y692	209	253	2	573	Chain	ID=PRO_0000074089;Note=Glucocorticoid modulatory element-binding protein 1
GMEB1	Q9Y692	253	299	2	573	Chain	ID=PRO_0000074089;Note=Glucocorticoid modulatory element-binding protein 1
GMPR	P36959	69	97	1	345	Chain	ID=PRO_0000093723;Note=GMP reductase 1
GMPR	P36959	97	155	1	345	Chain	ID=PRO_0000093723;Note=GMP reductase 1
GMPR	P36959	97	155	129	131	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03195
GMPR	P36959	69	97	78	78	Binding site	Note=NADP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03195
GMPR	P36959	69	97	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	69	97	73	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	69	97	82	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	69	97	93	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	97	155	93	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	97	155	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	97	155	107	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	97	155	125	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	97	155	136	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMPR	P36959	97	155	152	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BLE
GMIP	Q9P107	442	468	1	970	Chain	ID=PRO_0000056725;Note=GEM-interacting protein
GMIP	Q9P107	442	468	442	467	Alternative sequence	ID=VSP_056142;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HLA-G	P17693	114	206	25	338	Chain	ID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
HLA-G	P17693	114	206	25	338	Chain	ID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
HLA-G	P17693	114	206	25	308	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HLA-G	P17693	114	206	25	308	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HLA-G	P17693	114	206	25	114	Region	Note=Alpha-1
HLA-G	P17693	114	206	25	114	Region	Note=Alpha-1
HLA-G	P17693	114	206	115	206	Region	Note=Alpha-2
HLA-G	P17693	114	206	115	206	Region	Note=Alpha-2
HLA-G	P17693	114	206	125	188	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
HLA-G	P17693	114	206	125	188	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
HLA-G	P17693	114	206	115	298	Alternative sequence	ID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
HLA-G	P17693	114	206	115	298	Alternative sequence	ID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
HLA-G	P17693	114	206	115	206	Alternative sequence	ID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
HLA-G	P17693	114	206	115	206	Alternative sequence	ID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
HLA-G	P17693	114	206	116	116	Alternative sequence	ID=VSP_059193;Note=In isoform 7. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
HLA-G	P17693	114	206	116	116	Alternative sequence	ID=VSP_059193;Note=In isoform 7. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
HLA-G	P17693	114	206	117	338	Alternative sequence	ID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
HLA-G	P17693	114	206	117	338	Alternative sequence	ID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
HLA-G	P17693	114	206	113	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYP
HLA-G	P17693	114	206	113	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYP
HLA-G	P17693	114	206	118	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	118	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	134	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	134	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	145	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	145	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	162	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	162	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	176	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	176	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	187	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	187	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
HLA-G	P17693	114	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
IDNK	Q5T6J7	27	56	1	187	Chain	ID=PRO_0000327370;Note=Probable gluconokinase
IDNK	Q5T6J7	27	56	1	46	Alternative sequence	ID=VSP_032735;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF130	Q86XS8	231	255	28	419	Chain	ID=PRO_0000030718;Note=E3 ubiquitin-protein ligase RNF130
RNF130	Q86XS8	231	255	218	419	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAA1	O43292	25	84	2	621	Chain	ID=PRO_0000087554;Note=Glycosylphosphatidylinositol anchor attachment 1 protein
GPAA1	O43292	171	205	2	621	Chain	ID=PRO_0000087554;Note=Glycosylphosphatidylinositol anchor attachment 1 protein
GPAA1	O43292	25	84	25	45	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAA1	O43292	25	84	46	368	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAA1	O43292	171	205	46	368	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAA1	O43292	171	205	203	203	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPAA1	O43292	25	84	25	85	Alternative sequence	ID=VSP_009542;Note=In isoform 2. CVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSG->W;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GPAA1	O43292	25	84	51	51	Natural variant	ID=VAR_080543;Note=In GPIBD15%3B results in low amounts of GPI-anchored proteins on cell surface. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100095;Dbxref=PMID:29100095
GPAA1	O43292	25	84	54	54	Natural variant	ID=VAR_080544;Note=In GPIBD15%3B unknown pathological significance%3B requires 2 nucleotide substitutions. A->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100095;Dbxref=PMID:29100095
GPAA1	O43292	171	205	176	176	Natural variant	ID=VAR_080545;Note=In GPIBD15%3B results in low amounts of GPI-anchored proteins on cell surface. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100095;Dbxref=dbSNP:rs782220208,PMID:29100095
GPATCH1	Q9BRR8	428	528	2	931	Chain	ID=PRO_0000287457;Note=G patch domain-containing protein 1
GPATCH1	Q9BRR8	804	840	2	931	Chain	ID=PRO_0000287457;Note=G patch domain-containing protein 1
GPATCH1	Q9BRR8	428	528	477	477	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GPATCH1	Q9BRR8	428	528	476	476	Natural variant	ID=VAR_032303;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs2287679,PMID:17974005
GPATCH1	Q9BRR8	428	528	520	520	Natural variant	ID=VAR_051014;Note=L->S;Dbxref=dbSNP:rs16967805
GPATCH1	Q9BRR8	428	528	484	484	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPATCH2	Q9NW75	278	339	1	528	Chain	ID=PRO_0000087566;Note=G patch domain-containing protein 2
GRAP	Q13588	59	99	1	217	Chain	ID=PRO_0000088206;Note=GRB2-related adapter protein
GRAP	Q13588	59	99	60	154	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
GRIK1	P39086	402	417	31	918	Chain	ID=PRO_0000011541;Note=Glutamate receptor ionotropic%2C kainate 1
GRIK1	P39086	39	95	31	918	Chain	ID=PRO_0000011541;Note=Glutamate receptor ionotropic%2C kainate 1
GRIK1	P39086	402	417	31	576	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK1	P39086	39	95	31	576	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK1	P39086	39	95	68	68	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK1	P39086	39	95	74	74	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GRIK1	P39086	402	417	402	416	Alternative sequence	ID=VSP_000127;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8589992,ECO:0000303|Ref.3;Dbxref=PMID:8589992
GRAMD4	Q6IC98	521	544	1	578	Chain	ID=PRO_0000328742;Note=GRAM domain-containing protein 4
GRAMD4	Q6IC98	521	544	1	578	Chain	ID=PRO_0000328742;Note=GRAM domain-containing protein 4
GRAMD4	Q6IC98	521	544	445	523	Domain	Note=GRAM
GRAMD4	Q6IC98	521	544	445	523	Domain	Note=GRAM
GRHL3	Q8TE85	349	402	1	626	Chain	ID=PRO_0000227997;Note=Grainyhead-like protein 3 homolog
GRHL3	Q8TE85	349	402	391	391	Natural variant	ID=VAR_072617;Note=In VWS2. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24360809;Dbxref=dbSNP:rs879255245,PMID:24360809
GRHL3	Q8TE85	349	402	396	396	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
GRIA3	P42263	73	153	29	894	Chain	ID=PRO_0000011536;Note=Glutamate receptor 3
GRIA3	P42263	73	153	29	552	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
GRIA3	P42263	73	153	91	340	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4H	Q15056	136	156	2	248	Chain	ID=PRO_0000081619;Note=Eukaryotic translation initiation factor 4H
EIF4H	Q15056	136	156	137	157	Region	Note=HHV-1 Vhs binding site
EIF4H	Q15056	136	156	136	136	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUK2
EIF4H	Q15056	136	156	137	156	Alternative sequence	ID=VSP_005799;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7584026;Dbxref=PMID:14702039,PMID:15489334,PMID:7584026
HSPBAP1	Q96EW2	275	312	1	488	Chain	ID=PRO_0000284113;Note=HSPB1-associated protein 1
HSPBAP1	Q96EW2	247	275	1	488	Chain	ID=PRO_0000284113;Note=HSPB1-associated protein 1
HSPBAP1	Q96EW2	21	83	1	488	Chain	ID=PRO_0000284113;Note=HSPB1-associated protein 1
HSPBAP1	Q96EW2	275	312	124	288	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
HSPBAP1	Q96EW2	247	275	124	288	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
HSPBAP1	Q96EW2	275	312	226	488	Alternative sequence	ID=VSP_024443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HSPBAP1	Q96EW2	247	275	226	488	Alternative sequence	ID=VSP_024443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HSPBAP1	Q96EW2	275	312	250	280	Alternative sequence	ID=VSP_024444;Note=In isoform 3. FVPRHWWHYVESIDPVTVSINSWIELEEDHL->ERKWQEGTQLLLLVKRRMDFGGRQSTRVIFI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBAP1	Q96EW2	247	275	250	280	Alternative sequence	ID=VSP_024444;Note=In isoform 3. FVPRHWWHYVESIDPVTVSINSWIELEEDHL->ERKWQEGTQLLLLVKRRMDFGGRQSTRVIFI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBAP1	Q96EW2	275	312	281	488	Alternative sequence	ID=VSP_024445;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBAP1	Q96EW2	21	83	64	64	Natural variant	ID=VAR_031703;Note=S->A;Dbxref=dbSNP:rs16833517
HSPBAP1	Q96EW2	21	83	46	46	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
HEATR3	Q7Z4Q2	533	581	1	680	Chain	ID=PRO_0000050821;Note=HEAT repeat-containing protein 3
HEATR3	Q7Z4Q2	533	581	401	680	Alternative sequence	ID=VSP_009642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
HMGCR	P04035	521	574	1	888	Chain	ID=PRO_0000114419;Note=3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMGCR	P04035	766	819	1	888	Chain	ID=PRO_0000114419;Note=3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMGCR	P04035	521	574	1	888	Chain	ID=PRO_0000114419;Note=3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMGCR	P04035	766	819	1	888	Chain	ID=PRO_0000114419;Note=3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMGCR	P04035	521	574	450	888	Region	Note=Catalytic
HMGCR	P04035	766	819	450	888	Region	Note=Catalytic
HMGCR	P04035	521	574	450	888	Region	Note=Catalytic
HMGCR	P04035	766	819	450	888	Region	Note=Catalytic
HMGCR	P04035	521	574	559	559	Active site	Note=Charge relay system
HMGCR	P04035	521	574	559	559	Active site	Note=Charge relay system
HMGCR	P04035	766	819	767	767	Active site	Note=Charge relay system
HMGCR	P04035	766	819	767	767	Active site	Note=Charge relay system
HMGCR	P04035	521	574	522	574	Alternative sequence	ID=VSP_002207;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HMGCR	P04035	521	574	522	574	Alternative sequence	ID=VSP_002207;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HMGCR	P04035	521	574	519	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	519	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	522	525	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	522	525	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	528	546	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	528	546	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	549	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	549	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	562	575	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	521	574	562	575	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	768	770	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	768	770	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	771	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	771	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	777	785	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	777	785	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	790	800	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	790	800	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	804	806	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	804	806	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	807	810	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	807	810	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	812	820	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
HMGCR	P04035	766	819	812	820	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4F
GDI1	P31150	84	129	1	447	Chain	ID=PRO_0000056671;Note=Rab GDP dissociation inhibitor alpha
GDI1	P31150	196	239	1	447	Chain	ID=PRO_0000056671;Note=Rab GDP dissociation inhibitor alpha
GDI1	P31150	84	129	92	92	Natural variant	ID=VAR_008130;Note=In MRX41%3B causes reduced binding and recycling of RAB3A. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9620768;Dbxref=dbSNP:rs121434607,PMID:9620768
GFI1B	Q5VTD9	33	79	1	330	Chain	ID=PRO_0000306327;Note=Zinc finger protein Gfi-1b
GFI1B	Q5VTD9	170	216	1	330	Chain	ID=PRO_0000306327;Note=Zinc finger protein Gfi-1b
GFI1B	Q5VTD9	33	79	1	330	Chain	ID=PRO_0000306327;Note=Zinc finger protein Gfi-1b
GFI1B	Q5VTD9	170	216	1	330	Chain	ID=PRO_0000306327;Note=Zinc finger protein Gfi-1b
GFI1B	Q5VTD9	170	216	163	186	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GFI1B	Q5VTD9	170	216	163	186	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GFI1B	Q5VTD9	170	216	192	214	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GFI1B	Q5VTD9	170	216	192	214	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GFI1B	Q5VTD9	170	216	91	330	Region	Note=Interaction with ARIH2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17646546;Dbxref=PMID:17646546
GFI1B	Q5VTD9	170	216	91	330	Region	Note=Interaction with ARIH2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17646546;Dbxref=PMID:17646546
GFI1B	Q5VTD9	170	216	164	330	Region	Note=Mediates interaction with GATA1
GFI1B	Q5VTD9	170	216	164	330	Region	Note=Mediates interaction with GATA1
GFI1B	Q5VTD9	170	216	171	216	Alternative sequence	ID=VSP_028459;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GFI1B	Q5VTD9	170	216	171	216	Alternative sequence	ID=VSP_028459;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GFI1B	Q5VTD9	170	216	190	190	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
GFI1B	Q5VTD9	170	216	190	190	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
GFRA3	O60609	296	341	32	374	Chain	ID=PRO_0000010789;Note=GDNF family receptor alpha-3
GFRA3	O60609	126	157	32	374	Chain	ID=PRO_0000010789;Note=GDNF family receptor alpha-3
GFRA3	O60609	126	157	148	148	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GFRA3	O60609	296	341	309	309	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16765900;Dbxref=PMID:16765900
GFRA3	O60609	126	157	127	157	Alternative sequence	ID=VSP_010942;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:12975309,PMID:14702039
GFRA3	O60609	296	341	294	297	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GFRA3	O60609	296	341	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GFRA3	O60609	296	341	307	309	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GFRA3	O60609	296	341	312	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GFRA3	O60609	296	341	322	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GFRA3	O60609	296	341	325	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GFRA3	O60609	296	341	339	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GH0
GGA3	Q9NZ52	67	100	1	723	Chain	ID=PRO_0000212684;Note=ADP-ribosylation factor-binding protein GGA3
GGA3	Q9NZ52	67	100	16	146	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
GGA3	Q9NZ52	67	100	1	313	Region	Note=Binds to ARF1 (in long isoform)
GGA3	Q9NZ52	67	100	1	122	Alternative sequence	ID=VSP_045133;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GGA3	Q9NZ52	67	100	1	72	Alternative sequence	ID=VSP_046868;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GGA3	Q9NZ52	67	100	68	100	Alternative sequence	ID=VSP_001745;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10747089,ECO:0000303|PubMed:10749927,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8590280;Dbxref=PMID:10747089,PMID:10749927,PMID:15489334,PMID:8590280
GGA3	Q9NZ52	67	100	59	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JUQ
GGA3	Q9NZ52	67	100	77	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JUQ
GGA3	Q9NZ52	67	100	87	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JUQ
GGA3	Q9NZ52	67	100	99	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JUQ
GGT5	P36269	101	133	1	387	Chain	ID=PRO_0000011072;Note=Glutathione hydrolase 5 heavy chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
GGT5	P36269	501	538	388	586	Chain	ID=PRO_0000011073;Note=Glutathione hydrolase 5 light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
GGT5	P36269	501	538	30	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT5	P36269	101	133	30	586	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT5	P36269	101	133	110	110	Binding site	Note=Glutamate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GGT5	P36269	501	538	535	535	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT5	P36269	101	133	101	132	Alternative sequence	ID=VSP_008146;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GHR	P10912	23	45	19	638	Chain	ID=PRO_0000010957;Note=Growth hormone receptor
GHR	P10912	23	45	19	256	Chain	ID=PRO_0000010958;Note=Growth hormone-binding protein;Ontology_term=ECO:0000250;evidence=ECO:0000250
GHR	P10912	23	45	19	264	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GHR	P10912	23	45	24	24	Alternative sequence	ID=VSP_010225;Note=In isoform 4. A->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1569971;Dbxref=PMID:1569971
GHR	P10912	23	45	25	46	Alternative sequence	ID=VSP_010226;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1569971;Dbxref=PMID:1569971
GLB1L3	Q8NCI6	8	49	1	653	Chain	ID=PRO_0000283028;Note=Beta-galactosidase-1-like protein 3
GLB1L3	Q8NCI6	121	143	1	653	Chain	ID=PRO_0000283028;Note=Beta-galactosidase-1-like protein 3
GLB1L3	Q8NCI6	212	243	1	653	Chain	ID=PRO_0000283028;Note=Beta-galactosidase-1-like protein 3
GLB1L3	Q8NCI6	366	393	1	653	Chain	ID=PRO_0000283028;Note=Beta-galactosidase-1-like protein 3
GLB1L3	Q8NCI6	212	243	227	227	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLB1L3	Q8NCI6	8	49	1	339	Alternative sequence	ID=VSP_024280;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLB1L3	Q8NCI6	121	143	1	339	Alternative sequence	ID=VSP_024280;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLB1L3	Q8NCI6	212	243	1	339	Alternative sequence	ID=VSP_024280;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLB1L3	Q8NCI6	366	393	314	653	Alternative sequence	ID=VSP_024284;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT1	P34896	310	351	1	483	Chain	ID=PRO_0000113504;Note=Serine hydroxymethyltransferase%2C cytosolic
SHMT1	P34896	271	310	1	483	Chain	ID=PRO_0000113504;Note=Serine hydroxymethyltransferase%2C cytosolic
SHMT1	P34896	310	351	273	352	Alternative sequence	ID=VSP_006096;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHMT1	P34896	271	310	273	352	Alternative sequence	ID=VSP_006096;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHMT1	P34896	310	351	274	312	Alternative sequence	ID=VSP_006095;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT1	P34896	271	310	274	312	Alternative sequence	ID=VSP_006095;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT1	P34896	310	351	340	340	Natural variant	ID=VAR_059795;Note=E->Q;Dbxref=dbSNP:rs7215148
SHMT1	P34896	271	310	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	278	280	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	283	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	288	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	297	300	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	310	351	306	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	306	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	310	351	322	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
HJURP	Q8NCD3	134	165	1	748	Chain	ID=PRO_0000287433;Note=Holliday junction recognition protein
HJURP	Q8NCD3	134	165	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
HJURP	Q8NCD3	134	165	81	165	Alternative sequence	ID=VSP_037467;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HJURP	Q8NCD3	134	165	81	134	Alternative sequence	ID=VSP_037468;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GYG1	P46976	276	293	2	350	Chain	ID=PRO_0000215176;Note=Glycogenin-1;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG1	P46976	276	293	204	350	Alternative sequence	ID=VSP_001768;Note=In isoform GN-1S. FGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ->KMSQEPYHICPLGRSQLWHSRLYPRKNGRNDGNRARLIIWEQIPLTTSRGNLTLTSSRNTAFFCEHIHFTSLVSDT;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYG1	P46976	276	293	277	293	Alternative sequence	ID=VSP_001769;Note=In isoform GN-1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8602861,ECO:0000303|PubMed:8661012,ECO:0000303|Ref.6;Dbxref=PMID:15489334,PMID:8602861,PMID:8661012
GNPAT	O15228	26	87	1	680	Chain	ID=PRO_0000195246;Note=Dihydroxyacetone phosphate acyltransferase
GNPAT	O15228	426	507	1	680	Chain	ID=PRO_0000195246;Note=Dihydroxyacetone phosphate acyltransferase
GNPAT	O15228	26	87	27	87	Alternative sequence	ID=VSP_056435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNPAT	O15228	426	507	495	495	Natural variant	ID=VAR_030696;Note=V->I;Dbxref=dbSNP:rs11122266
GNPAT	O15228	26	87	26	26	Sequence conflict	Note=S->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
GNPAT	O15228	26	87	31	31	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPR157	Q5UAW9	199	264	1	335	Chain	ID=PRO_0000070339;Note=G-protein coupled receptor 157
GPR157	Q5UAW9	199	264	188	226	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR157	Q5UAW9	199	264	227	247	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR157	Q5UAW9	199	264	248	258	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR157	Q5UAW9	199	264	259	279	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAI1	Q9UI46	16	27	1	699	Chain	ID=PRO_0000114658;Note=Dynein intermediate chain 1%2C axonemal
DNAI1	Q9UI46	227	272	1	699	Chain	ID=PRO_0000114658;Note=Dynein intermediate chain 1%2C axonemal
DNAI1	Q9UI46	437	467	1	699	Chain	ID=PRO_0000114658;Note=Dynein intermediate chain 1%2C axonemal
DNAI1	Q9UI46	606	667	1	699	Chain	ID=PRO_0000114658;Note=Dynein intermediate chain 1%2C axonemal
DNAI1	Q9UI46	437	467	422	465	Repeat	Note=WD 3
DNAI1	Q9UI46	606	667	574	612	Repeat	Note=WD 6
DNAI1	Q9UI46	606	667	618	658	Repeat	Note=WD 7
DNAI1	Q9UI46	227	272	169	699	Alternative sequence	ID=VSP_056964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAI1	Q9UI46	437	467	169	699	Alternative sequence	ID=VSP_056964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAI1	Q9UI46	606	667	169	699	Alternative sequence	ID=VSP_056964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNPEP	Q9ULA0	284	312	1	475	Chain	ID=PRO_0000173451;Note=Aspartyl aminopeptidase
DNPEP	Q9ULA0	222	258	1	475	Chain	ID=PRO_0000173451;Note=Aspartyl aminopeptidase
DNPEP	Q9ULA0	284	312	302	302	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22720794;Dbxref=PMID:22720794
DNPEP	Q9ULA0	284	312	301	301	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22720794;Dbxref=PMID:22720794
DNPEP	Q9ULA0	222	258	218	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	222	258	232	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	222	258	235	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	222	258	249	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	222	258	252	255	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	222	258	257	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	284	312	283	288	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	284	312	291	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DNPEP	Q9ULA0	284	312	301	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DYO
DUOXA2	Q1HG44	68	113	1	320	Chain	ID=PRO_0000264245;Note=Dual oxidase maturation factor 2
DUOXA2	Q1HG44	68	113	57	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA2	Q1HG44	68	113	78	183	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA2	Q1HG44	68	113	84	84	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA2	Q1HG44	68	113	109	109	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA2	Q1HG44	68	113	50	121	Alternative sequence	ID=VSP_046554;Note=In isoform 2. RWFWLVRVLLSLFIGAEIVAVHFSAEWFVGTVNTNTSYKAFSAARVTARVRLLVGLEGINITLTGTPVHQLN->EYLHSHLLPSEIRLGPPSSEGGDPCVPSTSGLTEPHQAVTGPGGRTRTRRQTARGVKVVEECQEVGVEGRCC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DUOXA2	Q1HG44	68	113	100	100	Natural variant	ID=VAR_047367;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16651268;Dbxref=dbSNP:rs2576090,PMID:16651268
DOCK1	Q14185	379	421	1	1865	Chain	ID=PRO_0000189984;Note=Dedicator of cytokinesis protein 1
DOCK1	Q14185	463	496	1	1865	Chain	ID=PRO_0000189984;Note=Dedicator of cytokinesis protein 1
DOCK1	Q14185	649	679	1	1865	Chain	ID=PRO_0000189984;Note=Dedicator of cytokinesis protein 1
DOCK1	Q14185	713	757	1	1865	Chain	ID=PRO_0000189984;Note=Dedicator of cytokinesis protein 1
DOCK1	Q14185	928	962	1	1865	Chain	ID=PRO_0000189984;Note=Dedicator of cytokinesis protein 1
DOCK1	Q14185	1248	1288	1	1865	Chain	ID=PRO_0000189984;Note=Dedicator of cytokinesis protein 1
DOCK1	Q14185	463	496	425	609	Domain	Note=DHR-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00983
DOCK1	Q14185	1248	1288	1207	1617	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DOCK1	Q14185	463	496	493	499	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4C
GPCPD1	Q9NPB8	443	465	1	672	Chain	ID=PRO_0000050797;Note=Glycerophosphocholine phosphodiesterase GPCPD1
GPCPD1	Q9NPB8	383	409	1	672	Chain	ID=PRO_0000050797;Note=Glycerophosphocholine phosphodiesterase GPCPD1
GPCPD1	Q9NPB8	352	383	1	672	Chain	ID=PRO_0000050797;Note=Glycerophosphocholine phosphodiesterase GPCPD1
GPCPD1	Q9NPB8	443	465	318	618	Domain	Note=GP-PDE
GPCPD1	Q9NPB8	383	409	318	618	Domain	Note=GP-PDE
GPCPD1	Q9NPB8	352	383	318	618	Domain	Note=GP-PDE
GPD1L	Q8N335	75	122	1	351	Chain	ID=PRO_0000286511;Note=Glycerol-3-phosphate dehydrogenase 1-like protein
GPD1L	Q8N335	206	284	1	351	Chain	ID=PRO_0000286511;Note=Glycerol-3-phosphate dehydrogenase 1-like protein
GPD1L	Q8N335	206	284	271	272	Region	Note=Substrate binding
GPD1L	Q8N335	206	284	206	206	Active site	Note=Proton acceptor
GPD1L	Q8N335	75	122	99	99	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GPD1L	Q8N335	75	122	122	122	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GPD1L	Q8N335	206	284	271	271	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GPD1L	Q8N335	75	122	83	83	Natural variant	ID=VAR_044044;Note=In BRGDA2%3B unknown pathological significance%3B decreased enzymatic activity and significant reduction of sodium current when coexpressed with SCN5A in HEK cells. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17967976,ECO:0000269|PubMed:19666841;Dbxref=dbSNP:rs72552292,PMID:17967976,PMID:19666841
GPD1L	Q8N335	206	284	273	273	Natural variant	ID=VAR_044046;Note=In BRGDA2%3B unknown pathological significance%3B significant reduction of sodium current when coexpressed with SCN5A in HEK cells. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17967976;Dbxref=dbSNP:rs72552294,PMID:17967976
GPD1L	Q8N335	206	284	280	280	Natural variant	ID=VAR_044047;Note=In BRGDA2%3B unknown pathological significance%3B decreased enzymatic activity%3B affects SCN5A membrane expression%3B reduction of sodium current when coexpressed with SCN5A in HEK cells. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17967977,ECO:0000269|PubMed:19666841,ECO:0000269|PubMed:19745168;Dbxref=dbSNP:rs72552291,PMID:17967977,PMID:19666841,PMID:19745168
GPD1L	Q8N335	75	122	75	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	75	122	81	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	75	122	89	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	75	122	97	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	75	122	100	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	75	122	116	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	196	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	223	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	245	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	251	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	257	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	260	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
GPD1L	Q8N335	206	284	271	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PLA
EPS8L2	Q9H6S3	328	353	1	715	Chain	ID=PRO_0000239084;Note=Epidermal growth factor receptor kinase substrate 8-like protein 2
EPS8L2	Q9H6S3	328	353	1	715	Chain	ID=PRO_0000239084;Note=Epidermal growth factor receptor kinase substrate 8-like protein 2
EPS8L2	Q9H6S3	328	353	1	715	Chain	ID=PRO_0000239084;Note=Epidermal growth factor receptor kinase substrate 8-like protein 2
EPS8L2	Q9H6S3	328	353	1	388	Alternative sequence	ID=VSP_019092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874
EPS8L2	Q9H6S3	328	353	1	388	Alternative sequence	ID=VSP_019092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874
EPS8L2	Q9H6S3	328	353	1	388	Alternative sequence	ID=VSP_019092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874
GUF1	Q8N442	245	312	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
GUF1	Q8N442	445	493	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
GUF1	Q8N442	572	611	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
GUF1	Q8N442	245	312	66	247	Domain	Note=tr-type G
GUF1	Q8N442	572	611	609	609	Natural variant	ID=VAR_077804;Note=In EIEE40. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26486472;Dbxref=dbSNP:rs879255631,PMID:26486472
EPSTI1	Q96J88	219	230	1	318	Chain	ID=PRO_0000314034;Note=Epithelial-stromal interaction protein 1
EPSTI1	Q96J88	219	230	219	229	Alternative sequence	ID=VSP_030201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11991720,ECO:0000303|PubMed:14702039;Dbxref=PMID:11991720,PMID:14702039
ESPL1	Q14674	381	416	1	2120	Chain	ID=PRO_0000205900;Note=Separin
ESPL1	Q14674	1747	1788	1	2120	Chain	ID=PRO_0000205900;Note=Separin
ESPL1	Q14674	381	416	1	2120	Chain	ID=PRO_0000205900;Note=Separin
ESPL1	Q14674	1747	1788	1	2120	Chain	ID=PRO_0000205900;Note=Separin
ESR1	P03372	214	253	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	253	365	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	214	253	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	253	365	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	214	253	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	253	365	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	214	253	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	253	365	1	595	Chain	ID=PRO_0000053618;Note=Estrogen receptor
ESR1	P03372	253	365	311	547	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESR1	P03372	253	365	311	547	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESR1	P03372	253	365	311	547	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESR1	P03372	253	365	311	547	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESR1	P03372	214	253	185	250	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	185	250	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	185	250	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	185	250	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	221	245	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	221	245	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	221	245	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	221	245	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESR1	P03372	214	253	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	253	365	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	214	253	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	253	365	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	214	253	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	253	365	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	214	253	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	253	365	185	310	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15047147;Dbxref=PMID:15047147
ESR1	P03372	214	253	251	310	Region	Note=Hinge
ESR1	P03372	253	365	251	310	Region	Note=Hinge
ESR1	P03372	214	253	251	310	Region	Note=Hinge
ESR1	P03372	253	365	251	310	Region	Note=Hinge
ESR1	P03372	214	253	251	310	Region	Note=Hinge
ESR1	P03372	253	365	251	310	Region	Note=Hinge
ESR1	P03372	214	253	251	310	Region	Note=Hinge
ESR1	P03372	253	365	251	310	Region	Note=Hinge
ESR1	P03372	253	365	262	595	Region	Note=Interaction with AKAP13;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9627117;Dbxref=PMID:9627117
ESR1	P03372	253	365	262	595	Region	Note=Interaction with AKAP13;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9627117;Dbxref=PMID:9627117
ESR1	P03372	253	365	262	595	Region	Note=Interaction with AKAP13;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9627117;Dbxref=PMID:9627117
ESR1	P03372	253	365	262	595	Region	Note=Interaction with AKAP13;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9627117;Dbxref=PMID:9627117
ESR1	P03372	253	365	264	595	Region	Note=Self-association
ESR1	P03372	253	365	264	595	Region	Note=Self-association
ESR1	P03372	253	365	264	595	Region	Note=Self-association
ESR1	P03372	253	365	264	595	Region	Note=Self-association
ESR1	P03372	253	365	311	595	Region	Note=Transactivation AF-2
ESR1	P03372	253	365	311	595	Region	Note=Transactivation AF-2
ESR1	P03372	253	365	311	595	Region	Note=Transactivation AF-2
ESR1	P03372	253	365	311	595	Region	Note=Transactivation AF-2
ESR1	P03372	253	365	260	260	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	260	260	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	260	260	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	260	260	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	255	366	Alternative sequence	ID=VSP_003680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3753802;Dbxref=PMID:3753802
ESR1	P03372	253	365	255	366	Alternative sequence	ID=VSP_003680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3753802;Dbxref=PMID:3753802
ESR1	P03372	253	365	255	366	Alternative sequence	ID=VSP_003680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3753802;Dbxref=PMID:3753802
ESR1	P03372	253	365	255	366	Alternative sequence	ID=VSP_003680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3753802;Dbxref=PMID:3753802
ESR1	P03372	253	365	264	264	Natural variant	ID=VAR_033029;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=PMID:17224074
ESR1	P03372	253	365	264	264	Natural variant	ID=VAR_033029;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=PMID:17224074
ESR1	P03372	253	365	264	264	Natural variant	ID=VAR_033029;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=PMID:17224074
ESR1	P03372	253	365	264	264	Natural variant	ID=VAR_033029;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=PMID:17224074
ESR1	P03372	253	365	260	260	Mutagenesis	Note=Loss of methylation. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	260	260	Mutagenesis	Note=Loss of methylation. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	260	260	Mutagenesis	Note=Loss of methylation. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	260	260	Mutagenesis	Note=Loss of methylation. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657504;Dbxref=PMID:18657504
ESR1	P03372	253	365	364	364	Mutagenesis	Note=Has higher transcriptional activity in the absence of wild type ER. Inhibits transcriptional activity when coexpressed with the wild type receptor. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961262;Dbxref=PMID:8961262
ESR1	P03372	253	365	364	364	Mutagenesis	Note=Has higher transcriptional activity in the absence of wild type ER. Inhibits transcriptional activity when coexpressed with the wild type receptor. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961262;Dbxref=PMID:8961262
ESR1	P03372	253	365	364	364	Mutagenesis	Note=Has higher transcriptional activity in the absence of wild type ER. Inhibits transcriptional activity when coexpressed with the wild type receptor. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961262;Dbxref=PMID:8961262
ESR1	P03372	253	365	364	364	Mutagenesis	Note=Has higher transcriptional activity in the absence of wild type ER. Inhibits transcriptional activity when coexpressed with the wild type receptor. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961262;Dbxref=PMID:8961262
ESR1	P03372	214	253	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	231	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	231	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	231	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	231	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	214	253	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HCQ
ESR1	P03372	253	365	288	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLO
ESR1	P03372	253	365	288	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLO
ESR1	P03372	253	365	288	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLO
ESR1	P03372	253	365	288	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LLO
ESR1	P03372	253	365	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q95
ESR1	P03372	253	365	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q95
ESR1	P03372	253	365	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q95
ESR1	P03372	253	365	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q95
ESR1	P03372	253	365	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UUD
ESR1	P03372	253	365	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UUD
ESR1	P03372	253	365	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UUD
ESR1	P03372	253	365	307	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UUD
ESR1	P03372	253	365	312	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	312	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	312	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	312	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	330	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YJA
ESR1	P03372	253	365	330	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YJA
ESR1	P03372	253	365	330	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YJA
ESR1	P03372	253	365	330	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YJA
ESR1	P03372	253	365	334	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QZO
ESR1	P03372	253	365	334	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QZO
ESR1	P03372	253	365	334	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QZO
ESR1	P03372	253	365	334	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QZO
ESR1	P03372	253	365	339	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	339	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	339	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ESR1	P03372	253	365	339	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXE
ETV2	O00321	51	78	1	342	Chain	ID=PRO_0000204112;Note=ETS translocation variant 2
ETV2	O00321	51	78	1	342	Chain	ID=PRO_0000204112;Note=ETS translocation variant 2
EVPL	Q92817	856	887	1	2033	Chain	ID=PRO_0000078147;Note=Envoplakin
EVPL	Q92817	379	428	1	2033	Chain	ID=PRO_0000078147;Note=Envoplakin
EVPL	Q92817	337	379	1	2033	Chain	ID=PRO_0000078147;Note=Envoplakin
EVPL	Q92817	215	269	1	2033	Chain	ID=PRO_0000078147;Note=Envoplakin
EVPL	Q92817	215	269	229	330	Repeat	Note=Spectrin
EVPL	Q92817	379	428	413	470	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
EVPL	Q92817	379	428	1	841	Region	Note=Globular 1
EVPL	Q92817	337	379	1	841	Region	Note=Globular 1
EVPL	Q92817	215	269	1	841	Region	Note=Globular 1
EVPL	Q92817	856	887	842	1673	Region	Note=Central fibrous rod domain
EVPL	Q92817	856	887	845	1135	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC	P57679	267	313	1	992	Chain	ID=PRO_0000087102;Note=Ellis-van Creveld syndrome protein
EVC	P57679	488	521	1	992	Chain	ID=PRO_0000087102;Note=Ellis-van Creveld syndrome protein
EVC	P57679	521	592	1	992	Chain	ID=PRO_0000087102;Note=Ellis-van Creveld syndrome protein
EVC	P57679	267	313	49	992	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC	P57679	488	521	49	992	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC	P57679	521	592	49	992	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVC	P57679	267	313	307	307	Natural variant	ID=VAR_009944;Note=In WAD. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10700184;Dbxref=dbSNP:rs121908426,PMID:10700184
EVC	P57679	521	592	576	576	Natural variant	ID=VAR_009948;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10700184;Dbxref=dbSNP:rs1383180,PMID:10700184
EWSR1	Q01844	138	193	1	656	Chain	ID=PRO_0000081586;Note=RNA-binding protein EWS
EWSR1	Q01844	431	472	1	656	Chain	ID=PRO_0000081586;Note=RNA-binding protein EWS
EWSR1	Q01844	138	193	126	156	Repeat	Note=14
EWSR1	Q01844	138	193	157	163	Repeat	Note=15
EWSR1	Q01844	138	193	164	170	Repeat	Note=16
EWSR1	Q01844	138	193	171	177	Repeat	Note=17
EWSR1	Q01844	138	193	178	188	Repeat	Note=18
EWSR1	Q01844	138	193	189	193	Repeat	Note=19
EWSR1	Q01844	431	472	361	447	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
EWSR1	Q01844	138	193	1	285	Region	Note=EAD (Gln/Pro/Thr-rich)
EWSR1	Q01844	138	193	8	285	Region	Note=31 X approximate tandem repeats
EWSR1	Q01844	431	472	454	513	Compositional bias	Note=Arg/Gly/Pro-rich
EWSR1	Q01844	431	472	439	439	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61545
EWSR1	Q01844	431	472	455	455	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278906;Dbxref=PMID:11278906
EWSR1	Q01844	431	472	464	464	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278906;Dbxref=PMID:11278906
EWSR1	Q01844	431	472	471	471	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278906;Dbxref=PMID:11278906
EWSR1	Q01844	431	472	471	471	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|PubMed:11278906;Dbxref=PMID:24129315,PMID:11278906
EWSR1	Q01844	138	193	136	191	Alternative sequence	ID=VSP_045412;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EWSR1	Q01844	431	472	355	656	Alternative sequence	ID=VSP_043454;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EWSR1	Q01844	431	472	441	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPE
EVI5	O60447	674	706	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	642	674	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	593	642	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	540	593	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	493	540	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	430	448	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	232	257	1	810	Chain	ID=PRO_0000256241;Note=Ecotropic viral integration site 5 protein homolog
EVI5	O60447	232	257	163	348	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
EVI5	O60447	430	448	1	483	Region	Note=Interaction with alpha-tubulin%2C gamma-tubulin%2C BIRC5 and FBXO5;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16439210,ECO:0000269|PubMed:16764853;Dbxref=PMID:16439210,PMID:16764853
EVI5	O60447	232	257	1	483	Region	Note=Interaction with alpha-tubulin%2C gamma-tubulin%2C BIRC5 and FBXO5;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16439210,ECO:0000269|PubMed:16764853;Dbxref=PMID:16439210,PMID:16764853
EVI5	O60447	674	706	128	693	Region	Note=Dimerization
EVI5	O60447	642	674	128	693	Region	Note=Dimerization
EVI5	O60447	593	642	128	693	Region	Note=Dimerization
EVI5	O60447	540	593	128	693	Region	Note=Dimerization
EVI5	O60447	493	540	128	693	Region	Note=Dimerization
EVI5	O60447	430	448	128	693	Region	Note=Dimerization
EVI5	O60447	232	257	128	693	Region	Note=Dimerization
EVI5	O60447	674	706	377	810	Region	Note=Targeting to the centrosomes
EVI5	O60447	642	674	377	810	Region	Note=Targeting to the centrosomes
EVI5	O60447	593	642	377	810	Region	Note=Targeting to the centrosomes
EVI5	O60447	540	593	377	810	Region	Note=Targeting to the centrosomes
EVI5	O60447	493	540	377	810	Region	Note=Targeting to the centrosomes
EVI5	O60447	430	448	377	810	Region	Note=Targeting to the centrosomes
EVI5	O60447	674	706	487	810	Region	Note=Interaction with AURKB and INCENP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16764853;Dbxref=PMID:16764853
EVI5	O60447	642	674	487	810	Region	Note=Interaction with AURKB and INCENP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16764853;Dbxref=PMID:16764853
EVI5	O60447	593	642	487	810	Region	Note=Interaction with AURKB and INCENP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16764853;Dbxref=PMID:16764853
EVI5	O60447	540	593	487	810	Region	Note=Interaction with AURKB and INCENP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16764853;Dbxref=PMID:16764853
EVI5	O60447	493	540	487	810	Region	Note=Interaction with AURKB and INCENP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16764853;Dbxref=PMID:16764853
EVI5	O60447	674	706	406	716	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVI5	O60447	642	674	406	716	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVI5	O60447	593	642	406	716	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVI5	O60447	540	593	406	716	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVI5	O60447	493	540	406	716	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVI5	O60447	430	448	406	716	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EVI5	O60447	593	642	594	594	Site	Note=Breakpoint for translocation to form EVI5-TRNG10 fusion protein
EVI5	O60447	493	540	497	497	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
EVI5	O60447	674	706	689	689	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EVI5	O60447	430	448	448	448	Alternative sequence	ID=VSP_056828;Note=In isoform 2. K->KESASLADRLIQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19077034;Dbxref=PMID:19077034
EVI5	O60447	593	642	612	612	Natural variant	ID=VAR_028891;Note=Q->H;Dbxref=dbSNP:rs11808092
EYA3	Q99504	120	166	1	573	Chain	ID=PRO_0000218648;Note=Eyes absent homolog 3
EYA3	Q99504	120	166	1	126	Alternative sequence	ID=VSP_001493;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9049631;Dbxref=PMID:9049631
EYA3	Q99504	120	166	121	166	Alternative sequence	ID=VSP_054518;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
EYA3	Q99504	120	166	142	142	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EYA3	Q99504	120	166	151	151	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM117A	Q9C073	122	154	1	453	Chain	ID=PRO_0000264988;Note=Protein FAM117A
FAM117A	Q9C073	122	154	149	175	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM117A	Q9C073	122	154	1	272	Alternative sequence	ID=VSP_056129;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
F13A1	P00488	486	582	39	732	Chain	ID=PRO_0000033647;Note=Coagulation factor XIII A chain
F13A1	P00488	106	190	39	732	Chain	ID=PRO_0000033647;Note=Coagulation factor XIII A chain
F13A1	P00488	43	106	39	732	Chain	ID=PRO_0000033647;Note=Coagulation factor XIII A chain
F13A1	P00488	486	582	486	486	Metal binding	Note=Calcium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9988734;Dbxref=PMID:9988734
F13A1	P00488	486	582	491	491	Metal binding	Note=Calcium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9988734;Dbxref=PMID:9988734
F13A1	P00488	106	190	167	167	Natural variant	ID=VAR_074280;Note=In FA13AD%3B mild%3B no effect on intracellular protein abundance%3B no effect on protein-glutamine gamma-glutamyltransferase activity%3B no effect on alpha-2-antiplasmin to fibrin cross-linking activity%3B loss of fibrin alpha chain cross-linking activity%3B decreased clot fiber thickness. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889649,ECO:0000269|PubMed:27363989;Dbxref=PMID:24889649,PMID:27363989
F13A1	P00488	106	190	168	168	Natural variant	ID=VAR_077620;Note=In FA13AD%3B decreased intracellular protein abundance%3B decreased protein-glutamine gamma-glutamyltransferase activity%3B no effect on alpha-2-antiplasmin to fibrin cross-linking activity%3B loss of fibrin alpha chain cross-linking activity%3B decreased clot fiber thickness. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20179087,ECO:0000269|PubMed:27363989;Dbxref=PMID:20179087,PMID:27363989
F13A1	P00488	106	190	172	172	Natural variant	ID=VAR_074281;Note=In FA13AD%3B mild%3B decreased intracellular protein abundance%3B loss of protein-glutamine gamma-glutamyltransferase activity%3B decreased alpha-2-antiplasmin to fibrin cross-linking activity%3B decreased rate of fibrin gamma chain cross-linking activity%3B decreased rate of fibrin alpha chain cross-linking activity%3B decreased clot fiber thickness. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889649,ECO:0000269|PubMed:27363989;Dbxref=PMID:24889649,PMID:27363989
F13A1	P00488	486	582	530	530	Natural variant	ID=VAR_074288;Note=In FA13AD%3B mild%3B decreased intracellular protein abundance%3B loss of protein-glutamine gamma-glutamyltransferase activity%3B decreased alpha-2-antiplasmin to fibrin cross-linking activity%3B loss of fibrin gamma chain cross-linking activity%3B decreased clot fiber thickness. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889649,ECO:0000269|PubMed:27363989;Dbxref=PMID:24889649,PMID:27363989
F13A1	P00488	486	582	541	541	Natural variant	ID=VAR_077622;Note=In FA13AD%3B decreased intracellular protein abundance%3B no effect on protein-glutamine gamma-glutamyltransferase activity%3B no effect on alpha-2-antiplasmin to fibrin cross-linking activity%3B no effect on fibrin alpha chain and gamma chain cross-linking activity%3B decreased clot fiber thickness. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20179087,ECO:0000269|PubMed:27363989;Dbxref=PMID:20179087,PMID:27363989
F13A1	P00488	486	582	551	551	Natural variant	ID=VAR_013928;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs5984,PMID:10391209
F13A1	P00488	486	582	565	565	Natural variant	ID=VAR_007471;Note=In allele F13A*1A%2C allele F13A*2A and allele F13*(2)A. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:2901091,ECO:0000269|Ref.5;Dbxref=dbSNP:rs5982,PMID:10391209,PMID:2901091
F13A1	P00488	43	106	89	89	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
F13A1	P00488	43	106	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	43	106	48	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	43	106	60	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	43	106	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GGU
F13A1	P00488	43	106	74	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	43	106	81	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	43	106	95	97	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	43	106	100	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	112	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	116	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	132	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	142	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	156	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	169	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	106	190	181	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	489	501	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	519	527	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	534	542	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	544	546	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	548	559	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	561	563	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MHO
F13A1	P00488	486	582	565	578	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
F13A1	P00488	486	582	580	590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KTY
EYA1	Q99502	350	380	1	592	Chain	ID=PRO_0000218643;Note=Eyes absent homolog 1
EYA1	Q99502	322	350	1	592	Chain	ID=PRO_0000218643;Note=Eyes absent homolog 1
EYA1	Q99502	139	185	1	592	Chain	ID=PRO_0000218643;Note=Eyes absent homolog 1
EYA1	Q99502	350	380	1	592	Chain	ID=PRO_0000218643;Note=Eyes absent homolog 1
EYA1	Q99502	322	350	1	592	Chain	ID=PRO_0000218643;Note=Eyes absent homolog 1
EYA1	Q99502	139	185	1	592	Chain	ID=PRO_0000218643;Note=Eyes absent homolog 1
EYA1	Q99502	322	350	328	328	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	328	328	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	330	330	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	330	330	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	328	328	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	328	328	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	330	330	Metal binding	Note=Magnesium%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	322	350	330	330	Metal binding	Note=Magnesium%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00167
EYA1	Q99502	139	185	140	144	Alternative sequence	ID=VSP_045793;Note=In isoform EYA1D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
EYA1	Q99502	139	185	140	144	Alternative sequence	ID=VSP_045793;Note=In isoform EYA1D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
EYA1	Q99502	350	380	351	380	Alternative sequence	ID=VSP_045794;Note=In isoform EYA1D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
EYA1	Q99502	350	380	351	380	Alternative sequence	ID=VSP_045794;Note=In isoform EYA1D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
EYA1	Q99502	139	185	140	140	Natural variant	ID=VAR_064943;Note=In BOR1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21280147;Dbxref=PMID:21280147
EYA1	Q99502	139	185	140	140	Natural variant	ID=VAR_064943;Note=In BOR1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21280147;Dbxref=PMID:21280147
EYA1	Q99502	350	380	363	363	Natural variant	ID=VAR_016864;Note=In ASA. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10655545;Dbxref=dbSNP:rs121909198,PMID:10655545
EYA1	Q99502	350	380	363	363	Natural variant	ID=VAR_016864;Note=In ASA. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10655545;Dbxref=dbSNP:rs121909198,PMID:10655545
EYA1	Q99502	350	380	363	363	Natural variant	ID=VAR_064944;Note=In BOR1. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21280147;Dbxref=PMID:21280147
EYA1	Q99502	350	380	363	363	Natural variant	ID=VAR_064944;Note=In BOR1. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21280147;Dbxref=PMID:21280147
EYA1	Q99502	322	350	328	328	Mutagenesis	Note=Loss of tyrosine phosphatase activity toward H2AX. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19234442;Dbxref=PMID:19234442
EYA1	Q99502	322	350	328	328	Mutagenesis	Note=Loss of tyrosine phosphatase activity toward H2AX. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19234442;Dbxref=PMID:19234442
FAM184A	Q8NB25	1011	1046	1	1140	Chain	ID=PRO_0000089512;Note=Protein FAM184A
FAM184A	Q8NB25	923	971	1	1140	Chain	ID=PRO_0000089512;Note=Protein FAM184A
FAM184A	Q8NB25	53	338	1	1140	Chain	ID=PRO_0000089512;Note=Protein FAM184A
FAM184A	Q8NB25	53	338	57	256	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM184A	Q8NB25	53	338	296	800	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM184A	Q8NB25	53	338	1	120	Alternative sequence	ID=VSP_044520;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FAM184A	Q8NB25	923	971	924	972	Alternative sequence	ID=VSP_007446;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
FAM184A	Q8NB25	1011	1046	1012	1046	Alternative sequence	ID=VSP_007447;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM184A	Q8NB25	53	338	174	174	Natural variant	ID=VAR_054101;Note=Q->H;Dbxref=dbSNP:rs34681930
FAM184A	Q8NB25	53	338	177	177	Natural variant	ID=VAR_054102;Note=V->G;Dbxref=dbSNP:rs34977570
FAM214B	Q7L5A3	406	429	1	538	Chain	ID=PRO_0000313620;Note=Protein FAM214B
FAM214B	Q7L5A3	406	429	1	538	Chain	ID=PRO_0000313620;Note=Protein FAM214B
FAM214B	Q7L5A3	406	429	1	538	Chain	ID=PRO_0000313620;Note=Protein FAM214B
FAM214B	Q7L5A3	406	429	1	538	Chain	ID=PRO_0000313620;Note=Protein FAM214B
FAM214B	Q7L5A3	406	429	1	538	Chain	ID=PRO_0000313620;Note=Protein FAM214B
FAM214B	Q7L5A3	406	429	1	538	Chain	ID=PRO_0000313620;Note=Protein FAM214B
FAM227B	Q96M60	215	249	1	508	Chain	ID=PRO_0000244098;Note=Protein FAM227B
FAM227B	Q96M60	135	147	1	508	Chain	ID=PRO_0000244098;Note=Protein FAM227B
FAM227B	Q96M60	17	35	1	508	Chain	ID=PRO_0000244098;Note=Protein FAM227B
FAM227B	Q96M60	215	249	216	249	Alternative sequence	ID=VSP_019517;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM13B	Q9NYF5	698	726	1	915	Chain	ID=PRO_0000058924;Note=Protein FAM13B
FAM13B	Q9NYF5	297	348	1	915	Chain	ID=PRO_0000058924;Note=Protein FAM13B
FAM13B	Q9NYF5	698	726	699	726	Alternative sequence	ID=VSP_042048;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
F10	P00742	123	167	41	488	Chain	ID=PRO_0000027787;Note=Coagulation factor X
F10	P00742	123	167	41	179	Chain	ID=PRO_0000027788;Note=Factor X light chain
F10	P00742	123	167	125	165	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
F10	P00742	123	167	129	140	Disulfide bond	.
F10	P00742	123	167	136	149	Disulfide bond	.
F10	P00742	123	167	151	164	Disulfide bond	.
F10	P00742	123	167	142	142	Natural variant	ID=VAR_065434;Note=In FA10D%3B uncertain pathological significance%3B detected in patients carrying K-54 or P-374%3B slightly reduced activity. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10739379,ECO:0000269|PubMed:1973167,ECO:0000269|PubMed:7669671;Dbxref=dbSNP:rs61753266,PMID:10739379,PMID:1973167,PMID:7669671
F10	P00742	123	167	149	149	Natural variant	ID=VAR_065435;Note=In FA10D. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10746568;Dbxref=PMID:10746568
F10	P00742	123	167	151	151	Natural variant	ID=VAR_065436;Note=In FA10D. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10746568;Dbxref=PMID:10746568
F10	P00742	123	167	152	152	Natural variant	ID=VAR_020176;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs3211772
F10	P00742	123	167	123	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K9X
F10	P00742	123	167	129	131	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKH
F10	P00742	123	167	132	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKH
F10	P00742	123	167	137	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKH
F10	P00742	123	167	146	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKH
F10	P00742	123	167	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKH
F10	P00742	123	167	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKH
FAM76A	Q8TAV0	67	118	1	307	Chain	ID=PRO_0000245760;Note=Protein FAM76A
FAM76A	Q8TAV0	171	199	1	307	Chain	ID=PRO_0000245760;Note=Protein FAM76A
FAM76A	Q8TAV0	67	118	68	118	Alternative sequence	ID=VSP_043250;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM76A	Q8TAV0	171	199	172	200	Alternative sequence	ID=VSP_019772;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
FAM32A	Q9Y421	72	90	1	112	Chain	ID=PRO_0000223250;Note=Protein FAM32A
FAM32A	Q9Y421	72	90	9	86	Compositional bias	Note=Lys-rich
FAM32A	Q9Y421	72	90	74	112	Alternative sequence	ID=VSP_043861;Note=In isoform 2. MERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK->GHQTSCIATGFQGHKANAARSYAWIQNWYCVPSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FABP4	P15090	82	116	2	132	Chain	ID=PRO_0000067366;Note=Fatty acid-binding protein%2C adipocyte
FABP4	P15090	82	116	80	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6D
FABP4	P15090	82	116	91	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6D
FABP4	P15090	82	116	101	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6D
FABP4	P15090	82	116	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6D
FADS3	Q9Y5Q0	208	249	1	445	Chain	ID=PRO_0000307108;Note=Fatty acid desaturase 3
FADS3	Q9Y5Q0	108	174	1	445	Chain	ID=PRO_0000307108;Note=Fatty acid desaturase 3
FADS3	Q9Y5Q0	108	174	1	133	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS3	Q9Y5Q0	108	174	134	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS3	Q9Y5Q0	108	174	155	159	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS3	Q9Y5Q0	108	174	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS3	Q9Y5Q0	208	249	181	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS3	Q9Y5Q0	208	249	219	223	Motif	Note=Histidine box-2
FADS3	Q9Y5Q0	208	249	216	216	Natural variant	ID=VAR_035342;Note=N->K;Dbxref=dbSNP:rs34511441
FAF1	Q9UNN5	248	280	1	650	Chain	ID=PRO_0000211038;Note=FAS-associated factor 1
FAF1	Q9UNN5	219	248	1	650	Chain	ID=PRO_0000211038;Note=FAS-associated factor 1
FAF1	Q9UNN5	248	280	188	339	Alternative sequence	ID=VSP_006704;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10462485;Dbxref=PMID:10462485
FAF1	Q9UNN5	219	248	188	339	Alternative sequence	ID=VSP_006704;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10462485;Dbxref=PMID:10462485
EPS15	P42566	627	639	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	559	597	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	491	559	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	425	491	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	187	217	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	167	187	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	125	167	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	71	103	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	11	25	2	896	Chain	ID=PRO_0000146116;Note=Epidermal growth factor receptor substrate 15
EPS15	P42566	71	103	15	104	Domain	Note=EH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15	P42566	11	25	15	104	Domain	Note=EH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15	P42566	187	217	128	216	Domain	Note=EH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15	P42566	167	187	128	216	Domain	Note=EH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15	P42566	125	167	128	216	Domain	Note=EH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00077
EPS15	P42566	187	217	160	195	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EPS15	P42566	167	187	160	195	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EPS15	P42566	125	167	160	195	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
EPS15	P42566	627	639	629	631	Repeat	Note=3
EPS15	P42566	627	639	634	636	Repeat	Note=4
EPS15	P42566	167	187	173	184	Calcium binding	Note=1
EPS15	P42566	187	217	2	330	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15	P42566	167	187	2	330	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15	P42566	125	167	2	330	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15	P42566	71	103	2	330	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15	P42566	11	25	2	330	Region	Note=Interaction with DAB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPS15	P42566	627	639	599	827	Region	Note=15 X 3 AA repeats of D-P-F
EPS15	P42566	125	167	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
EPS15	P42566	425	491	467	467	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
EPS15	P42566	425	491	470	470	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
EPS15	P42566	425	491	485	485	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:17525332,PMID:18669648,PMID:21406692
EPS15	P42566	559	597	562	562	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42567
EPS15	P42566	559	597	563	563	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42567
EPS15	P42566	187	217	1	314	Alternative sequence	ID=VSP_036168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPS15	P42566	167	187	1	314	Alternative sequence	ID=VSP_036168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPS15	P42566	125	167	1	314	Alternative sequence	ID=VSP_036168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPS15	P42566	71	103	1	314	Alternative sequence	ID=VSP_036168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPS15	P42566	11	25	1	314	Alternative sequence	ID=VSP_036168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPS15	P42566	125	167	154	154	Mutagenesis	Note=Loss of interaction with STON2 NPF motifs. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18200045;Dbxref=PMID:18200045
EPS15	P42566	167	187	169	169	Mutagenesis	Note=Loss of interaction with STON2 NPF motifs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18200045;Dbxref=PMID:18200045
EPS15	P42566	425	491	446	446	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPS15	P42566	125	167	126	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	125	167	142	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	125	167	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JXC
EPS15	P42566	125	167	148	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	125	167	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	167	187	162	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	125	167	162	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	167	187	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	187	217	182	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	167	187	182	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	187	217	207	209	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EH2
EPS15	P42566	187	217	212	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F8H
EPS15	P42566	627	639	624	627	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JP2
EPS15	P42566	627	639	630	633	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JP2
SLC2A3	P11169	322	356	1	496	Chain	ID=PRO_0000050353;Note=Solute carrier family 2%2C facilitated glucose transporter member 3
SLC2A3	P11169	322	356	305	325	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:26176916;Dbxref=PMID:26176916
SLC2A3	P11169	322	356	326	331	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC2A3	P11169	322	356	332	352	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:26176916;Dbxref=PMID:26176916
SLC2A3	P11169	322	356	353	363	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC2A3	P11169	322	356	304	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZW9
SLC2A3	P11169	322	356	356	358	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZW9
SLC2A5	P22732	332	366	1	501	Chain	ID=PRO_0000050369;Note=Solute carrier family 2%2C facilitated glucose transporter member 5
SLC2A5	P22732	332	366	314	334	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43427
SLC2A5	P22732	332	366	335	342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43427
SLC2A5	P22732	332	366	343	363	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43427
SLC2A5	P22732	332	366	364	371	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43427
SLC2A5	P22732	332	366	192	501	Alternative sequence	ID=VSP_042031;Note=In isoform 2. WPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ->EFRTSREHPHPFTTTLGPLLVFQSHHHRTGLSADWSLLTGWMSLGGPSCPEPT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SLC2A8	Q9NY64	73	142	1	477	Chain	ID=PRO_0000050375;Note=Solute carrier family 2%2C facilitated glucose transporter member 8
SLC2A8	Q9NY64	241	289	1	477	Chain	ID=PRO_0000050375;Note=Solute carrier family 2%2C facilitated glucose transporter member 8
SLC2A8	Q9NY64	325	383	1	477	Chain	ID=PRO_0000050375;Note=Solute carrier family 2%2C facilitated glucose transporter member 8
SLC2A8	Q9NY64	73	142	71	91	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	73	142	92	96	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	73	142	97	117	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	73	142	118	127	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	73	142	128	148	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	241	289	204	256	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	241	289	257	277	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	241	289	278	292	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	325	383	320	340	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	325	383	341	367	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	325	383	368	388	Transmembrane	Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A8	Q9NY64	241	289	267	273	Region	Note=Monosaccharide binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC2A8	Q9NY64	325	383	349	349	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC2A8	Q9NY64	241	289	253	253	Natural variant	ID=VAR_061880;Note=I->T;Dbxref=dbSNP:rs34064803
SLC2A8	Q9NY64	325	383	377	377	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPN2	O95208	198	255	1	641	Chain	ID=PRO_0000074516;Note=Epsin-2
EPN2	O95208	441	470	1	641	Chain	ID=PRO_0000074516;Note=Epsin-2
EPN2	O95208	470	542	1	641	Chain	ID=PRO_0000074516;Note=Epsin-2
EPN2	O95208	470	542	537	539	Repeat	Note=1
EPN2	O95208	441	470	352	639	Region	Note=6 X 3 AA repeats of [DE]-P-W
EPN2	O95208	470	542	352	639	Region	Note=6 X 3 AA repeats of [DE]-P-W
EPN2	O95208	470	542	537	639	Region	Note=3 X 3 AA repeats of N-P-F
EPN2	O95208	470	542	486	486	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1Z3
EPN2	O95208	470	542	508	508	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1Z3
EPN2	O95208	198	255	1	285	Alternative sequence	ID=VSP_047003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPN2	O95208	198	255	200	256	Alternative sequence	ID=VSP_009155;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10567358,ECO:0000303|PubMed:14702039;Dbxref=PMID:10567358,PMID:14702039
EPN2	O95208	470	542	531	531	Natural variant	ID=VAR_047923;Note=P->T;Dbxref=dbSNP:rs1062727
EPN2	O95208	470	542	532	532	Natural variant	ID=VAR_053081;Note=P->T;Dbxref=dbSNP:rs1062727
EPN3	Q9H201	227	254	1	632	Chain	ID=PRO_0000074519;Note=Epsin-3
EPN3	Q9H201	254	297	1	632	Chain	ID=PRO_0000074519;Note=Epsin-3
EPN3	Q9H201	326	416	1	632	Chain	ID=PRO_0000074519;Note=Epsin-3
EPN3	Q9H201	416	451	1	632	Chain	ID=PRO_0000074519;Note=Epsin-3
EPN3	Q9H201	227	254	209	228	Domain	Note=UIM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00213
EPN3	Q9H201	227	254	236	255	Domain	Note=UIM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00213
EPN3	Q9H201	254	297	236	255	Domain	Note=UIM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00213
EPN3	Q9H201	326	416	344	346	Repeat	Note=2
EPN3	Q9H201	326	416	371	373	Repeat	Note=3
EPN3	Q9H201	326	416	387	389	Repeat	Note=4
EPN3	Q9H201	326	416	404	406	Repeat	Note=5
EPN3	Q9H201	326	416	321	406	Region	Note=5 X 3 AA repeats of [DE]-P-W
EPN3	Q9H201	254	297	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91W69
EPN3	Q9H201	227	254	209	632	Alternative sequence	ID=VSP_009159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EPN3	Q9H201	254	297	209	632	Alternative sequence	ID=VSP_009159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EPN3	Q9H201	326	416	209	632	Alternative sequence	ID=VSP_009159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EPN3	Q9H201	416	451	209	632	Alternative sequence	ID=VSP_009159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EPN3	Q9H201	326	416	375	375	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPN3	Q9H201	326	416	396	396	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPN3	Q9H201	416	451	417	417	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SQLE	Q14534	274	312	1	574	Chain	ID=PRO_0000209838;Note=Squalene monooxygenase
SQLE	Q14534	369	401	1	574	Chain	ID=PRO_0000209838;Note=Squalene monooxygenase
SQLE	Q14534	369	401	379	380	Sequence conflict	Note=AT->VA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SQLE	Q14534	369	401	389	389	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERGIC1	Q969X5	125	160	1	290	Chain	ID=PRO_0000087023;Note=Endoplasmic reticulum-Golgi intermediate compartment protein 1
ERGIC1	Q969X5	125	160	48	254	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERGIC1	Q969X5	125	160	127	204	Alternative sequence	ID=VSP_011563;Note=In isoform 3. PGNFHVSTHSATAQPQNPDMTHVIHKLSFGDTLQVQNIHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQR->WKPCLSPFYLLPFPAVSPLPGNWLWRHSLDLTLTQPPASEGSCPAAWPFLLRIWMGVQAPWGFKPLMAGSGRSYSSLQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.4;Dbxref=PMID:11230166
ERGIC2	Q96RQ1	159	190	1	377	Chain	ID=PRO_0000239382;Note=Endoplasmic reticulum-Golgi intermediate compartment protein 2
ERGIC2	Q96RQ1	159	190	55	319	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERLIN1	O75477	218	248	1	346	Chain	ID=PRO_0000002784;Note=Erlin-1
ERLIN1	O75477	101	143	1	346	Chain	ID=PRO_0000002784;Note=Erlin-1
ERLIN1	O75477	218	248	1	346	Chain	ID=PRO_0000002784;Note=Erlin-1
ERLIN1	O75477	101	143	1	346	Chain	ID=PRO_0000002784;Note=Erlin-1
ERLIN1	O75477	218	248	27	346	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERLIN1	O75477	101	143	27	346	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERLIN1	O75477	218	248	27	346	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERLIN1	O75477	101	143	27	346	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERLIN1	O75477	101	143	106	106	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ERLIN1	O75477	101	143	106	106	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ERI3	O43414	202	222	1	337	Chain	ID=PRO_0000317626;Note=ERI1 exoribonuclease 3
ERI3	O43414	163	202	1	337	Chain	ID=PRO_0000317626;Note=ERI1 exoribonuclease 3
ERI3	O43414	202	222	146	320	Domain	Note=Exonuclease
ERI3	O43414	163	202	146	320	Domain	Note=Exonuclease
ERI3	O43414	202	222	1	209	Alternative sequence	ID=VSP_031104;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERI3	O43414	163	202	1	209	Alternative sequence	ID=VSP_031104;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERI3	O43414	163	202	1	163	Alternative sequence	ID=VSP_031103;Note=In isoform 2. MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHPGHWGFPALTEPSASPAAGLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVLGSHLFSPCGVPEFCSISTRKLAAHGFGASMAAMVSFPPQRYHYFLVLDFEATCDKPQIHPQ->MFVMLQVPWLQSCANLVQIGAPLPLLGCLGQYFEVLGSMEVLAGQYGM;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERI3	O43414	163	202	165	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	163	202	175	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	163	202	180	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	163	202	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	202	222	198	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	163	202	198	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	202	222	208	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERI3	O43414	202	222	217	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XRI
ERICH1	Q86X53	354	419	1	443	Chain	ID=PRO_0000087029;Note=Glutamate-rich protein 1
ERICH1	Q86X53	101	354	1	443	Chain	ID=PRO_0000087029;Note=Glutamate-rich protein 1
ERICH1	Q86X53	56	101	1	443	Chain	ID=PRO_0000087029;Note=Glutamate-rich protein 1
ERICH1	Q86X53	7	56	1	443	Chain	ID=PRO_0000087029;Note=Glutamate-rich protein 1
ERICH1	Q86X53	101	354	193	328	Compositional bias	Note=Glu-rich
ERICH1	Q86X53	7	56	12	12	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ERICH1	Q86X53	101	354	238	238	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
ERICH1	Q86X53	101	354	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
ERICH1	Q86X53	101	354	277	277	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
ERICH1	Q86X53	354	419	365	365	Natural variant	ID=VAR_035915;Note=In a colorectal cancer sample%3B somatic mutation. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs774405503,PMID:16959974
ERICH1	Q86X53	354	419	403	403	Natural variant	ID=VAR_050974;Note=R->S;Dbxref=dbSNP:rs1703879
ERN2	Q76MJ5	449	501	35	926	Chain	ID=PRO_0000024329;Note=Serine/threonine-protein kinase/endoribonuclease IRE2
ERN2	Q76MJ5	210	244	35	926	Chain	ID=PRO_0000024329;Note=Serine/threonine-protein kinase/endoribonuclease IRE2
ERN2	Q76MJ5	210	244	35	430	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERN2	Q76MJ5	449	501	431	451	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERN2	Q76MJ5	449	501	452	926	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERN2	Q76MJ5	449	501	487	487	Natural variant	ID=VAR_040501;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11175748,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs26764,PMID:11175748,PMID:17344846
ERN2	Q76MJ5	210	244	215	215	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	210	244	218	218	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	210	244	227	227	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	449	501	453	453	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	449	501	468	468	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	449	501	472	474	Sequence conflict	Note=FAH->TAD;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	449	501	486	486	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERN2	Q76MJ5	449	501	488	491	Sequence conflict	Note=RRSQ->LRSK;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERP27	Q96DN0	150	192	26	273	Chain	ID=PRO_0000281118;Note=Endoplasmic reticulum resident protein 27
ERP27	Q96DN0	150	192	39	152	Domain	Note=Thioredoxin
ERP27	Q96DN0	150	192	168	168	Mutagenesis	Note=Decreases somatostatin-14 binding. M->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16940051;Dbxref=PMID:16940051
ERP27	Q96DN0	150	192	149	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9Z
ERP27	Q96DN0	150	192	162	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9Z
ERP27	Q96DN0	150	192	175	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9Z
ERP27	Q96DN0	150	192	189	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9Z
ESRP2	Q9H6T0	443	514	1	727	Chain	ID=PRO_0000273050;Note=Epithelial splicing regulatory protein 2
ESRP2	Q9H6T0	443	514	475	555	Domain	Note=RRM 3
ETFDH	Q16134	11	58	1	33	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
ETFDH	Q16134	11	58	34	617	Chain	ID=PRO_0000008661;Note=Electron transfer flavoprotein-ubiquinone oxidoreductase%2C mitochondrial
ETFDH	Q16134	277	324	34	617	Chain	ID=PRO_0000008661;Note=Electron transfer flavoprotein-ubiquinone oxidoreductase%2C mitochondrial
ETFDH	Q16134	324	372	34	617	Chain	ID=PRO_0000008661;Note=Electron transfer flavoprotein-ubiquinone oxidoreductase%2C mitochondrial
ETFDH	Q16134	428	489	34	617	Chain	ID=PRO_0000008661;Note=Electron transfer flavoprotein-ubiquinone oxidoreductase%2C mitochondrial
ETFDH	Q16134	428	489	428	447	Intramembrane	Ontology_term=ECO:0000250;evidence=ECO:0000250
ETFDH	Q16134	277	324	305	305	Binding site	Note=Ubiquinone%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ETFDH	Q16134	277	324	306	306	Binding site	Note=Ubiquinone%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ETFDH	Q16134	324	372	357	357	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q921G7
ETFDH	Q16134	11	58	12	58	Alternative sequence	ID=VSP_055158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ETFDH	Q16134	11	58	16	16	Natural variant	ID=VAR_075438;Note=F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12359134;Dbxref=PMID:12359134
ETFDH	Q16134	11	58	31	31	Natural variant	ID=VAR_062966;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12359134,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:8306995;Dbxref=dbSNP:rs11559290,PMID:12359134,PMID:15489334,PMID:17974005,PMID:8306995
ETFDH	Q16134	11	58	49	49	Natural variant	ID=VAR_075439;Note=In GA2C%3B unknown pathological significance. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12359134;Dbxref=PMID:12359134
ETFDH	Q16134	324	372	334	334	Natural variant	ID=VAR_075451;Note=In GA2C%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12359134;Dbxref=dbSNP:rs377686388,PMID:12359134
ETFDH	Q16134	324	372	346	346	Natural variant	ID=VAR_075452;Note=In GA2C%3B unknown pathological significance. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12359134;Dbxref=PMID:12359134
ETFDH	Q16134	428	489	452	452	Natural variant	ID=VAR_075454;Note=In GA2C%3B unknown pathological significance. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12359134;Dbxref=PMID:12359134
ETFDH	Q16134	428	489	456	456	Natural variant	ID=VAR_075455;Note=In GA2C. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12359134,ECO:0000269|PubMed:17412732;Dbxref=dbSNP:rs398124152,PMID:12359134,PMID:17412732
ETFDH	Q16134	428	489	456	456	Natural variant	ID=VAR_075456;Note=In GA2C. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16527485;Dbxref=PMID:16527485
ETFDH	Q16134	428	489	483	483	Natural variant	ID=VAR_075457;Note=In GA2C%3B unknown pathological significance. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17412732;Dbxref=dbSNP:rs377656387,PMID:17412732
ETFDH	Q16134	428	489	456	456	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ETFA	P13804	294	321	20	333	Chain	ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial
ETFA	P13804	272	294	20	333	Chain	ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial
ETFA	P13804	221	244	20	333	Chain	ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial
ETFA	P13804	150	187	20	333	Chain	ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial
ETFA	P13804	272	294	281	286	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055
ETFA	P13804	294	321	318	319	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055
ETFA	P13804	150	187	20	204	Region	Note=Domain I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055
ETFA	P13804	294	321	205	333	Region	Note=Domain II;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055
ETFA	P13804	272	294	205	333	Region	Note=Domain II;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055
ETFA	P13804	221	244	205	333	Region	Note=Domain II;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055
ETFA	P13804	221	244	223	223	Binding site	Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055
ETFA	P13804	294	321	300	300	Binding site	Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055
ETFA	P13804	150	187	158	158	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	150	187	158	158	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	150	187	164	164	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	150	187	187	187	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	221	244	226	226	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	221	244	226	226	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	221	244	232	232	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	221	244	232	232	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	294	321	301	301	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5
ETFA	P13804	150	187	157	157	Natural variant	ID=VAR_002367;Note=In GA2A. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1882842;Dbxref=dbSNP:rs119458969,PMID:1882842
ETFA	P13804	150	187	171	171	Natural variant	ID=VAR_008547;Note=Decreased protein stability. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10356313;Dbxref=dbSNP:rs1801591,PMID:10356313
ETFA	P13804	150	187	149	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	150	187	153	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	150	187	162	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	150	187	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	150	187	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	150	187	184	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	221	244	216	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	221	244	223	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	221	244	229	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	221	244	232	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	221	244	244	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	272	294	273	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	272	294	284	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	272	294	288	292	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	294	321	294	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	272	294	294	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	294	321	306	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	294	321	312	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFA	P13804	294	321	319	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETS2	P15036	0	24	1	469	Chain	ID=PRO_0000204077;Note=Protein C-ets-2
ETS2	P15036	168	196	1	469	Chain	ID=PRO_0000204077;Note=Protein C-ets-2
ETS2	P15036	196	270	1	469	Chain	ID=PRO_0000204077;Note=Protein C-ets-2
ETS2	P15036	0	24	1	469	Chain	ID=PRO_0000204077;Note=Protein C-ets-2
ETS2	P15036	168	196	1	469	Chain	ID=PRO_0000204077;Note=Protein C-ets-2
ETS2	P15036	196	270	1	469	Chain	ID=PRO_0000204077;Note=Protein C-ets-2
ETS2	P15036	168	196	85	170	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ETS2	P15036	168	196	85	170	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ETS2	P15036	196	270	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24218572;Dbxref=PMID:24218572
ETS2	P15036	196	270	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24218572;Dbxref=PMID:24218572
ETS2	P15036	196	270	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24218572;Dbxref=PMID:24218572
ETS2	P15036	196	270	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24218572;Dbxref=PMID:24218572
ETS2	P15036	168	196	155	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MHV
ETS2	P15036	168	196	155	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MHV
EXOC3L1	Q86VI1	462	498	1	746	Chain	ID=PRO_0000309474;Note=Exocyst complex component 3-like protein
EXOC3L1	Q86VI1	386	428	1	746	Chain	ID=PRO_0000309474;Note=Exocyst complex component 3-like protein
EXOC6B	Q9Y2D4	555	600	1	811	Chain	ID=PRO_0000118954;Note=Exocyst complex component 6B
EXOC6B	Q9Y2D4	282	305	1	811	Chain	ID=PRO_0000118954;Note=Exocyst complex component 6B
EXOC6B	Q9Y2D4	223	282	1	811	Chain	ID=PRO_0000118954;Note=Exocyst complex component 6B
EXOC6B	Q9Y2D4	93	109	1	811	Chain	ID=PRO_0000118954;Note=Exocyst complex component 6B
EXOC6B	Q9Y2D4	93	109	50	119	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EXOC1	Q9NV70	443	458	2	894	Chain	ID=PRO_0000118913;Note=Exocyst complex component 1
EXOC1	Q9NV70	513	549	2	894	Chain	ID=PRO_0000118913;Note=Exocyst complex component 1
EXOC1	Q9NV70	443	458	2	894	Chain	ID=PRO_0000118913;Note=Exocyst complex component 1
EXOC1	Q9NV70	513	549	2	894	Chain	ID=PRO_0000118913;Note=Exocyst complex component 1
EXOC1	Q9NV70	443	458	444	459	Alternative sequence	ID=VSP_001481;Note=In isoform 2. ATLPRKESAVKQETES->G;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
EXOC1	Q9NV70	443	458	444	459	Alternative sequence	ID=VSP_001481;Note=In isoform 2. ATLPRKESAVKQETES->G;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
EXOSC5	Q9NQT4	175	205	1	235	Chain	ID=PRO_0000139975;Note=Exosome complex component RRP46
EXOSC5	Q9NQT4	175	205	171	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC5	Q9NQT4	175	205	178	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC5	Q9NQT4	175	205	187	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC5	Q9NQT4	175	205	194	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC5	Q9NQT4	175	205	203	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
FAM149B1	Q96BN6	376	450	1	582	Chain	ID=PRO_0000319933;Note=Protein FAM149B1
FAM149B1	Q96BN6	492	534	1	582	Chain	ID=PRO_0000319933;Note=Protein FAM149B1
FAM19A3	Q7Z5A8	38	88	31	133	Chain	ID=PRO_0000042726;Note=Protein FAM19A3
FAM19A4	Q96LR4	43	95	36	140	Chain	ID=PRO_0000042728;Note=Protein FAM19A4
FAM13A	O94988	528	556	1	1023	Chain	ID=PRO_0000058920;Note=Protein FAM13A
FAM13A	O94988	468	496	1	1023	Chain	ID=PRO_0000058920;Note=Protein FAM13A
FAM13A	O94988	24	37	1	1023	Chain	ID=PRO_0000058920;Note=Protein FAM13A
FAM13A	O94988	10	23	1	1023	Chain	ID=PRO_0000058920;Note=Protein FAM13A
FAM13A	O94988	24	37	1	354	Alternative sequence	ID=VSP_039152;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM13A	O94988	10	23	1	354	Alternative sequence	ID=VSP_039152;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM13A	O94988	24	37	1	340	Alternative sequence	ID=VSP_039153;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM13A	O94988	10	23	1	340	Alternative sequence	ID=VSP_039153;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM13A	O94988	24	37	1	326	Alternative sequence	ID=VSP_039154;Note=In isoform 1 and isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:14702039;Dbxref=PMID:10048485,PMID:14702039
FAM13A	O94988	10	23	1	326	Alternative sequence	ID=VSP_039154;Note=In isoform 1 and isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:14702039;Dbxref=PMID:10048485,PMID:14702039
FAM86C1	Q9NVL1	53	87	1	165	Chain	ID=PRO_0000307640;Note=Protein FAM86C1
FAM86C1	Q9NVL1	53	87	53	87	Alternative sequence	ID=VSP_042069;Note=In isoform 3. KHEAVHTEPLDELYEVLVETLMAKESTQGHRSYLL->KTVKHPVCVKHPPSVKYARCFLSELIKK;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM86C1	Q9NVL1	53	87	54	87	Alternative sequence	ID=VSP_028752;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM86C1	Q9NVL1	53	87	70	70	Natural variant	ID=VAR_036621;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16554811;Dbxref=dbSNP:rs3935309,PMID:14702039,PMID:16554811
GSTM3	P21266	156	193	1	225	Chain	ID=PRO_0000185822;Note=Glutathione S-transferase Mu 3
GSTM3	P21266	156	193	1	225	Chain	ID=PRO_0000185822;Note=Glutathione S-transferase Mu 3
GSTM3	P21266	156	193	94	212	Domain	Note=GST C-terminal
GSTM3	P21266	156	193	94	212	Domain	Note=GST C-terminal
GSTM3	P21266	156	193	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	159	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	159	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	176	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	176	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
GSTM3	P21266	156	193	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GTU
ESPNL	Q6ZVH7	285	329	1	1005	Chain	ID=PRO_0000312511;Note=Espin-like protein
ESPNL	Q6ZVH7	285	329	270	299	Repeat	Note=ANK 9
ESPNL	Q6ZVH7	285	329	329	394	Compositional bias	Note=Pro-rich
ESPNL	Q6ZVH7	285	329	1	368	Alternative sequence	ID=VSP_029858;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ESPNL	Q6ZVH7	285	329	286	329	Alternative sequence	ID=VSP_029859;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ESPN	B1AK53	225	286	1	854	Chain	ID=PRO_0000334666;Note=Espin
ESPN	B1AK53	286	330	1	854	Chain	ID=PRO_0000334666;Note=Espin
ESPN	B1AK53	687	775	1	854	Chain	ID=PRO_0000334666;Note=Espin
ESPN	B1AK53	225	286	205	235	Repeat	Note=ANK 7
ESPN	B1AK53	225	286	239	268	Repeat	Note=ANK 8
ESPN	B1AK53	225	286	271	300	Repeat	Note=ANK 9
ESPN	B1AK53	286	330	271	300	Repeat	Note=ANK 9
ESPN	B1AK53	687	775	756	830	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ESPN	B1AK53	687	775	428	730	Compositional bias	Note=Pro-rich
ESPN	B1AK53	687	775	768	825	Compositional bias	Note=Glu-rich
ESPN	B1AK53	687	775	690	690	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ET47
ESPN	B1AK53	687	775	696	696	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63618
ESPN	B1AK53	225	286	1	536	Alternative sequence	ID=VSP_033728;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
ESPN	B1AK53	286	330	1	536	Alternative sequence	ID=VSP_033728;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
ESPN	B1AK53	286	330	322	322	Natural variant	ID=VAR_043451;Note=R->H;Dbxref=dbSNP:rs3817911
ESPN	B1AK53	286	330	323	323	Natural variant	ID=VAR_043452;Note=Y->C;Dbxref=dbSNP:rs3817910
ESPN	B1AK53	687	775	719	719	Natural variant	ID=VAR_043453;Note=In DFNB36%3B irregular microvillar organization. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15930085;Dbxref=dbSNP:rs121908134,PMID:15930085
ESPN	B1AK53	687	775	744	744	Natural variant	ID=VAR_043454;Note=In DFNB36%3B irregular microvillar organization. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15930085;Dbxref=dbSNP:rs121908135,PMID:15930085
ESPN	B1AK53	687	775	774	774	Natural variant	ID=VAR_043455;Note=In DFNB36%3B sporadic case with mild phenotype%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15930085;Dbxref=dbSNP:rs121908136,PMID:15930085
ESPN	B1AK53	687	775	773	774	Sequence conflict	Note=RR->SW;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMG6	Q86US8	1119	1178	1	1419	Chain	ID=PRO_0000087069;Note=Telomerase-binding protein EST1A
SMG6	Q86US8	680	717	1	1419	Chain	ID=PRO_0000087069;Note=Telomerase-binding protein EST1A
SMG6	Q86US8	680	717	1	1089	Alternative sequence	ID=VSP_010360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMG6	Q86US8	680	717	1	908	Alternative sequence	ID=VSP_047157;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMG6	Q86US8	1119	1178	1090	1119	Alternative sequence	ID=VSP_010361;Note=In isoform 2. ILEEDRLLSGFVPLLAAPQDPCYVEKTSDK->MRFRLCHQRGCCPHERENTCTCKMIISSLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMG6	Q86US8	680	717	667	696	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
SMG6	Q86US8	680	717	700	703	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
SMG6	Q86US8	680	717	716	742	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
SMG6	Q86US8	1119	1178	1119	1139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
SMG6	Q86US8	1119	1178	1140	1143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
SMG6	Q86US8	1119	1178	1145	1149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
SMG6	Q86US8	1119	1178	1152	1155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM2
ESRP1	Q6NXG1	44	87	1	681	Chain	ID=PRO_0000273046;Note=Epithelial splicing regulatory protein 1
ESRP1	Q6NXG1	215	251	1	681	Chain	ID=PRO_0000273046;Note=Epithelial splicing regulatory protein 1
ESRP1	Q6NXG1	411	484	1	681	Chain	ID=PRO_0000273046;Note=Epithelial splicing regulatory protein 1
ESRP1	Q6NXG1	215	251	225	302	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
ESRP1	Q6NXG1	411	484	445	525	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
ESRP1	Q6NXG1	411	484	406	416	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHA
ESRP1	Q6NXG1	411	484	446	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RVJ
ESRP1	Q6NXG1	411	484	458	465	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RVJ
ESRP1	Q6NXG1	411	484	466	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RVJ
ESRP1	Q6NXG1	411	484	471	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RVJ
ELSPBP1	Q96BH3	23	69	1	24	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
ELSPBP1	Q96BH3	23	69	25	223	Chain	ID=PRO_0000308249;Note=Epididymal sperm-binding protein 1
ELSPBP1	Q96BH3	23	69	25	68	Domain	Note=Fibronectin type-II 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
ELSPBP1	Q96BH3	23	69	69	117	Domain	Note=Fibronectin type-II 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00479
CES3	Q6UWW8	307	354	27	571	Chain	ID=PRO_0000305191;Note=Carboxylesterase 3
CES3	Q6UWW8	354	381	27	571	Chain	ID=PRO_0000305191;Note=Carboxylesterase 3
CES3	Q6UWW8	307	354	347	347	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
CES3	Q6UWW8	307	354	1	361	Alternative sequence	ID=VSP_044994;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CES3	Q6UWW8	354	381	1	361	Alternative sequence	ID=VSP_044994;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CES3	Q6UWW8	354	381	367	367	Natural variant	ID=VAR_060704;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs61743167
CES3	Q6UWW8	354	381	372	372	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ETHE1	O95571	168	198	8	254	Chain	ID=PRO_0000012289;Note=Persulfide dioxygenase ETHE1%2C mitochondrial
ETHE1	O95571	168	198	172	172	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM0
ETHE1	O95571	168	198	172	172	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCM0
ETHE1	O95571	168	198	185	185	Natural variant	ID=VAR_023398;Note=In EE. L->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14732903,ECO:0000269|PubMed:18593870;Dbxref=dbSNP:rs387906987,PMID:14732903,PMID:18593870
ETHE1	O95571	168	198	196	196	Natural variant	ID=VAR_069511;Note=In EE%3B reduces protein stability and affinity for substrate. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18593870,ECO:0000269|PubMed:23144459;Dbxref=dbSNP:rs763799125,PMID:18593870,PMID:23144459
ETHE1	O95571	168	198	171	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHL
ETHE1	O95571	168	198	182	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHL
ETHE1	O95571	168	198	190	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHL
ETHE1	O95571	168	198	197	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CHL
ETV4	P43268	128	181	1	484	Chain	ID=PRO_0000204116;Note=ETS translocation variant 4
ETV4	P43268	51	67	1	484	Chain	ID=PRO_0000204116;Note=ETS translocation variant 4
ETV4	P43268	128	181	1	484	Chain	ID=PRO_0000204116;Note=ETS translocation variant 4
ETV4	P43268	51	67	1	484	Chain	ID=PRO_0000204116;Note=ETS translocation variant 4
ETV4	P43268	128	181	1	484	Chain	ID=PRO_0000204116;Note=ETS translocation variant 4
ETV4	P43268	51	67	1	484	Chain	ID=PRO_0000204116;Note=ETS translocation variant 4
ETV4	P43268	51	67	49	75	Compositional bias	Note=Asp/Glu-rich (acidic)
ETV4	P43268	51	67	49	75	Compositional bias	Note=Asp/Glu-rich (acidic)
ETV4	P43268	51	67	49	75	Compositional bias	Note=Asp/Glu-rich (acidic)
ETV4	P43268	128	181	148	244	Compositional bias	Note=Gln-rich
ETV4	P43268	128	181	148	244	Compositional bias	Note=Gln-rich
ETV4	P43268	128	181	148	244	Compositional bias	Note=Gln-rich
ETV4	P43268	128	181	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETV4	P43268	128	181	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETV4	P43268	128	181	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETV4	P43268	128	181	149	149	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETV4	P43268	128	181	149	149	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETV4	P43268	128	181	149	149	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETV4	P43268	128	181	139	139	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ETV4	P43268	128	181	139	139	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ETV4	P43268	128	181	139	139	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ETV4	P43268	128	181	1	277	Alternative sequence	ID=VSP_055314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETV4	P43268	51	67	1	277	Alternative sequence	ID=VSP_055314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETV4	P43268	128	181	1	277	Alternative sequence	ID=VSP_055314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETV4	P43268	51	67	1	277	Alternative sequence	ID=VSP_055314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETV4	P43268	128	181	1	277	Alternative sequence	ID=VSP_055314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETV4	P43268	51	67	1	277	Alternative sequence	ID=VSP_055314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EVA1C	P58658	160	211	49	441	Chain	ID=PRO_0000017671;Note=Protein eva-1 homolog C
EVA1C	P58658	211	259	49	441	Chain	ID=PRO_0000017671;Note=Protein eva-1 homolog C
EVA1C	P58658	259	286	49	441	Chain	ID=PRO_0000017671;Note=Protein eva-1 homolog C
EVA1C	P58658	286	316	49	441	Chain	ID=PRO_0000017671;Note=Protein eva-1 homolog C
EVA1C	P58658	160	211	49	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVA1C	P58658	211	259	49	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVA1C	P58658	259	286	49	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVA1C	P58658	286	316	49	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVA1C	P58658	160	211	168	260	Domain	Note=SUEL-type lectin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00260
EVA1C	P58658	211	259	168	260	Domain	Note=SUEL-type lectin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00260
EVA1C	P58658	259	286	168	260	Domain	Note=SUEL-type lectin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00260
EVA1C	P58658	160	211	165	165	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EVA1C	P58658	160	211	70	441	Alternative sequence	ID=VSP_003104;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
EVA1C	P58658	211	259	70	441	Alternative sequence	ID=VSP_003104;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
EVA1C	P58658	259	286	70	441	Alternative sequence	ID=VSP_003104;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
EVA1C	P58658	286	316	70	441	Alternative sequence	ID=VSP_003104;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
EVA1C	P58658	259	286	285	287	Alternative sequence	ID=VSP_055198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EVA1C	P58658	286	316	285	287	Alternative sequence	ID=VSP_055198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EVA1C	P58658	259	286	284	286	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EVA1C	P58658	286	316	284	286	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
C22orf23	Q9BZE7	55	116	1	217	Chain	ID=PRO_0000221089;Note=UPF0193 protein EVG1
C22orf23	Q9BZE7	34	55	1	217	Chain	ID=PRO_0000221089;Note=UPF0193 protein EVG1
C22orf23	Q9BZE7	55	116	1	217	Chain	ID=PRO_0000221089;Note=UPF0193 protein EVG1
C22orf23	Q9BZE7	34	55	1	217	Chain	ID=PRO_0000221089;Note=UPF0193 protein EVG1
C22orf23	Q9BZE7	55	116	1	217	Chain	ID=PRO_0000221089;Note=UPF0193 protein EVG1
C22orf23	Q9BZE7	34	55	1	217	Chain	ID=PRO_0000221089;Note=UPF0193 protein EVG1
EXO1	Q9UQ84	54	93	1	846	Chain	ID=PRO_0000154039;Note=Exonuclease 1
EXO1	Q9UQ84	703	737	1	846	Chain	ID=PRO_0000154039;Note=Exonuclease 1
EXO1	Q9UQ84	54	93	1	846	Chain	ID=PRO_0000154039;Note=Exonuclease 1
EXO1	Q9UQ84	703	737	1	846	Chain	ID=PRO_0000154039;Note=Exonuclease 1
EXO1	Q9UQ84	54	93	1	99	Region	Note=N-domain
EXO1	Q9UQ84	54	93	1	99	Region	Note=N-domain
EXO1	Q9UQ84	703	737	600	846	Region	Note=Interaction with MSH2
EXO1	Q9UQ84	703	737	600	846	Region	Note=Interaction with MSH2
EXO1	Q9UQ84	54	93	78	78	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
EXO1	Q9UQ84	54	93	78	78	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
EXO1	Q9UQ84	703	737	714	714	Modified residue	Note=Phosphoserine%3B by ATR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18048416;Dbxref=PMID:18048416
EXO1	Q9UQ84	703	737	714	714	Modified residue	Note=Phosphoserine%3B by ATR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18048416;Dbxref=PMID:18048416
EXO1	Q9UQ84	54	93	76	76	Natural variant	ID=VAR_024967;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs4149864
EXO1	Q9UQ84	54	93	76	76	Natural variant	ID=VAR_024967;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs4149864
EXO1	Q9UQ84	54	93	93	93	Natural variant	ID=VAR_024968;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs4149865
EXO1	Q9UQ84	54	93	93	93	Natural variant	ID=VAR_024968;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs4149865
EXO1	Q9UQ84	703	737	723	723	Natural variant	ID=VAR_024988;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10364235,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:9685493,ECO:0000269|PubMed:9788596,ECO:0000269|PubMed:9823303,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1635498,PMID:10364235,PMID:15489334,PMID:17974005,PMID:9685493,PMID:9788596,PMID:9823303
EXO1	Q9UQ84	703	737	723	723	Natural variant	ID=VAR_024988;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10364235,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:9685493,ECO:0000269|PubMed:9788596,ECO:0000269|PubMed:9823303,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1635498,PMID:10364235,PMID:15489334,PMID:17974005,PMID:9685493,PMID:9788596,PMID:9823303
EXO1	Q9UQ84	703	737	726	726	Natural variant	ID=VAR_024989;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14756672;Dbxref=PMID:14756672
EXO1	Q9UQ84	703	737	726	726	Natural variant	ID=VAR_024989;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14756672;Dbxref=PMID:14756672
EXO1	Q9UQ84	54	93	78	78	Mutagenesis	Note=Abrogates double-stranded DNA exonuclease activity and endonuclease activity against 5'-overhanging flap structures. Also reduces DNA-binding to 5'-overhanging flap structures. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11842105;Dbxref=PMID:11842105
EXO1	Q9UQ84	54	93	78	78	Mutagenesis	Note=Abrogates double-stranded DNA exonuclease activity and endonuclease activity against 5'-overhanging flap structures. Also reduces DNA-binding to 5'-overhanging flap structures. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11842105;Dbxref=PMID:11842105
EXO1	Q9UQ84	703	737	714	714	Mutagenesis	Note=No rescue of HU-induced degradation and loss of HU-induced increase of phosphorylation. No rescue of HU-induced degradation%3B when associated with A-621. No rescue of HU-induced degradation%3B when associated with A-454. Loss of HU-sensitivity and resistance to HU-induced degradation%3B when associated with A-454 and A-621. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18048416;Dbxref=PMID:18048416
EXO1	Q9UQ84	703	737	714	714	Mutagenesis	Note=No rescue of HU-induced degradation and loss of HU-induced increase of phosphorylation. No rescue of HU-induced degradation%3B when associated with A-621. No rescue of HU-induced degradation%3B when associated with A-454. Loss of HU-sensitivity and resistance to HU-induced degradation%3B when associated with A-454 and A-621. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18048416;Dbxref=PMID:18048416
EXO1	Q9UQ84	54	93	54	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	54	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	72	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	72	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	86	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
EXO1	Q9UQ84	54	93	86	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V07
FAM118B	Q9BPY3	113	189	2	351	Chain	ID=PRO_0000295103;Note=Protein FAM118B
FAM118B	Q9BPY3	189	232	2	351	Chain	ID=PRO_0000295103;Note=Protein FAM118B
FAM118B	Q9BPY3	327	347	2	351	Chain	ID=PRO_0000295103;Note=Protein FAM118B
FAM118B	Q9BPY3	113	189	133	133	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXOSC9	Q06265	128	174	1	439	Chain	ID=PRO_0000139971;Note=Exosome complex component RRP45
EXOSC9	Q06265	276	324	1	439	Chain	ID=PRO_0000139971;Note=Exosome complex component RRP45
EXOSC9	Q06265	128	174	1	268	Region	Note=ARE binding
EXOSC9	Q06265	276	324	297	297	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
EXOSC9	Q06265	276	324	306	306	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EXOSC9	Q06265	276	324	297	297	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
EXOSC9	Q06265	276	324	297	297	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
EXOSC9	Q06265	128	174	128	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	128	174	146	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	276	324	244	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	276	324	287	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	276	324	291	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
FAM199X	Q6PEV8	139	189	1	388	Chain	ID=PRO_0000251210;Note=Protein FAM199X
FAM227A	F5H4B4	207	242	1	570	Chain	ID=PRO_0000419264;Note=Protein FAM227A
FAM20A	Q96MK3	196	213	34	541	Chain	ID=PRO_0000008743;Note=Pseudokinase FAM20A
FAM20A	Q96MK3	196	213	197	214	Natural variant	ID=VAR_066859;Note=In AI1G. DYSQDEKALLGACDCTQI->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990045;Dbxref=PMID:21990045
FAM20A	Q96MK3	196	213	193	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WRR
FAM20A	Q96MK3	196	213	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WRR
FAM20A	Q96MK3	196	213	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WRR
FAM20A	Q96MK3	196	213	212	214	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WRR
FAH	P16930	320	354	2	419	Chain	ID=PRO_0000156825;Note=Fumarylacetoacetase
FAH	P16930	320	354	2	419	Chain	ID=PRO_0000156825;Note=Fumarylacetoacetase
FAH	P16930	320	354	2	419	Chain	ID=PRO_0000156825;Note=Fumarylacetoacetase
FAH	P16930	320	354	350	350	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35505
FAH	P16930	320	354	350	350	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35505
FAH	P16930	320	354	350	350	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35505
FAH	P16930	320	354	337	337	Natural variant	ID=VAR_005218;Note=In TYRSN1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7757089;Dbxref=dbSNP:rs80338900,PMID:7757089
FAH	P16930	320	354	337	337	Natural variant	ID=VAR_005218;Note=In TYRSN1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7757089;Dbxref=dbSNP:rs80338900,PMID:7757089
FAH	P16930	320	354	337	337	Natural variant	ID=VAR_005218;Note=In TYRSN1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7757089;Dbxref=dbSNP:rs80338900,PMID:7757089
FAH	P16930	320	354	341	341	Natural variant	ID=VAR_005219;Note=Functional polymorphism%3B does not cause a clinically relevant phenotype%3B results in lower enzyme activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11278491,ECO:0000269|PubMed:27535533,ECO:0000269|PubMed:7977370;Dbxref=dbSNP:rs11555096,PMID:11278491,PMID:27535533,PMID:7977370
FAH	P16930	320	354	341	341	Natural variant	ID=VAR_005219;Note=Functional polymorphism%3B does not cause a clinically relevant phenotype%3B results in lower enzyme activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11278491,ECO:0000269|PubMed:27535533,ECO:0000269|PubMed:7977370;Dbxref=dbSNP:rs11555096,PMID:11278491,PMID:27535533,PMID:7977370
FAH	P16930	320	354	341	341	Natural variant	ID=VAR_005219;Note=Functional polymorphism%3B does not cause a clinically relevant phenotype%3B results in lower enzyme activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11278491,ECO:0000269|PubMed:27535533,ECO:0000269|PubMed:7977370;Dbxref=dbSNP:rs11555096,PMID:11278491,PMID:27535533,PMID:7977370
FAH	P16930	320	354	342	342	Natural variant	ID=VAR_005220;Note=In TYRSN1%3B loss of activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8005583;Dbxref=dbSNP:rs779040832,PMID:8005583
FAH	P16930	320	354	342	342	Natural variant	ID=VAR_005220;Note=In TYRSN1%3B loss of activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8005583;Dbxref=dbSNP:rs779040832,PMID:8005583
FAH	P16930	320	354	342	342	Natural variant	ID=VAR_005220;Note=In TYRSN1%3B loss of activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8005583;Dbxref=dbSNP:rs779040832,PMID:8005583
H2AFV	Q71UI9	1	27	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000305;evidence=ECO:0000305
H2AFV	Q71UI9	27	65	2	128	Chain	ID=PRO_0000239068;Note=Histone H2A.V
H2AFV	Q71UI9	1	27	2	128	Chain	ID=PRO_0000239068;Note=Histone H2A.V
H2AFV	Q71UI9	1	27	5	5	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3THW5
H2AFV	Q71UI9	1	27	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3THW5
H2AFV	Q71UI9	1	27	12	12	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3THW5
H2AFV	Q71UI9	27	65	1	27	Alternative sequence	ID=VSP_045232;Note=In isoform 4. MAGGKAGKDSGKAKAKAVSRSQRAGLQ->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
H2AFV	Q71UI9	1	27	1	27	Alternative sequence	ID=VSP_045232;Note=In isoform 4. MAGGKAGKDSGKAKAKAVSRSQRAGLQ->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
H2AFV	Q71UI9	27	65	28	65	Alternative sequence	ID=VSP_044633;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
H2AFV	Q71UI9	1	27	20	23	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAA
H2AFV	Q71UI9	27	65	30	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAA
H2AFV	Q71UI9	27	65	49	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAA
H2AFY2	Q9P0M6	93	159	1	372	Chain	ID=PRO_0000055320;Note=Core histone macro-H2A.2
H2AFY2	Q9P0M6	159	196	1	372	Chain	ID=PRO_0000055320;Note=Core histone macro-H2A.2
H2AFY2	Q9P0M6	229	259	1	372	Chain	ID=PRO_0000055320;Note=Core histone macro-H2A.2
H2AFY2	Q9P0M6	93	159	2	117	Domain	Note=Histone H2A
H2AFY2	Q9P0M6	159	196	184	370	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
H2AFY2	Q9P0M6	229	259	184	370	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
H2AFY2	Q9P0M6	93	159	118	161	Compositional bias	Note=Lys-rich
H2AFY2	Q9P0M6	159	196	118	161	Compositional bias	Note=Lys-rich
H2AFY2	Q9P0M6	229	259	239	239	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
H2AFY2	Q9P0M6	159	196	183	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FY5
H2AFY2	Q9P0M6	159	196	196	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FY5
H2AFY2	Q9P0M6	229	259	227	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FY5
FABP6	P51161	81	111	2	128	Chain	ID=PRO_0000067380;Note=Gastrotropin
FABP6	P51161	81	111	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L8I
FABP6	P51161	81	111	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L8I
FABP6	P51161	81	111	90	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L8I
FABP6	P51161	81	111	98	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L8I
FABP6	P51161	81	111	106	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L8I
FABP7	O15540	82	116	2	132	Chain	ID=PRO_0000067373;Note=Fatty acid-binding protein%2C brain
FABP7	O15540	82	116	110	110	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FABP7	O15540	82	116	80	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5URA
FABP7	O15540	82	116	91	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5URA
FABP7	O15540	82	116	101	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5URA
FABP7	O15540	82	116	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5URA
FABP3	P05413	82	116	2	133	Chain	ID=PRO_0000067321;Note=Fatty acid-binding protein%2C heart
FABP3	P05413	82	116	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07483
FABP3	P05413	82	116	105	105	Sequence conflict	Note=L->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
FABP3	P05413	82	116	80	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TKB
FABP3	P05413	82	116	91	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TKB
FABP3	P05413	82	116	101	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TKB
FABP3	P05413	82	116	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TKB
FAM102A	Q5T9C2	99	138	1	384	Chain	ID=PRO_0000261634;Note=Protein FAM102A
FAM102A	Q5T9C2	89	99	1	384	Chain	ID=PRO_0000261634;Note=Protein FAM102A
FAM102A	Q5T9C2	99	138	2	145	Domain	Note=C2 NT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01186
FAM102A	Q5T9C2	89	99	2	145	Domain	Note=C2 NT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01186
FAM102A	Q5T9C2	99	138	1	142	Alternative sequence	ID=VSP_043857;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM102A	Q5T9C2	89	99	1	142	Alternative sequence	ID=VSP_043857;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAAH2	Q6GMR7	137	207	1	532	Chain	ID=PRO_0000291993;Note=Fatty-acid amide hydrolase 2
FAAH2	Q6GMR7	207	247	1	532	Chain	ID=PRO_0000291993;Note=Fatty-acid amide hydrolase 2
FAAH2	Q6GMR7	332	372	1	532	Chain	ID=PRO_0000291993;Note=Fatty-acid amide hydrolase 2
FAAH2	Q6GMR7	409	474	1	532	Chain	ID=PRO_0000291993;Note=Fatty-acid amide hydrolase 2
FAAH2	Q6GMR7	137	207	206	206	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
FAAH2	Q6GMR7	207	247	230	230	Active site	Note=Acyl-ester intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
FANCD2	Q9BXW9	21	68	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	378	426	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	471	515	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	515	552	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	609	649	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	831	868	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	905	953	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	953	992	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	1075	1111	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	1283	1296	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	1296	1321	1	1451	Chain	ID=PRO_0000087168;Note=Fanconi anemia group D2 protein
FANCD2	Q9BXW9	21	68	1	291	Region	Note=Interaction with FANCE
FANCD2	Q9BXW9	378	426	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	471	515	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	515	552	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	609	649	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	831	868	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	905	953	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	953	992	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	1075	1111	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	1283	1296	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	1296	1321	242	1451	Alternative sequence	ID=VSP_013884;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCD2	Q9BXW9	1283	1296	1250	1451	Alternative sequence	ID=VSP_013886;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FANCD2	Q9BXW9	1296	1321	1250	1451	Alternative sequence	ID=VSP_013886;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FANCD2	Q9BXW9	21	68	33	33	Natural variant	ID=VAR_025827;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34691009
FANCD2	Q9BXW9	21	68	61	61	Natural variant	ID=VAR_025828;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs35110529
FANCD2	Q9BXW9	21	68	65	65	Natural variant	ID=VAR_025829;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs36084488
FANCD2	Q9BXW9	609	649	623	623	Natural variant	ID=VAR_025835;Note=Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs36070315
FANCD2	Q9BXW9	831	868	865	865	Natural variant	ID=VAR_025836;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs35546777
RCE1	Q9Y256	96	124	2	329	Chain	ID=PRO_0000194830;Note=CAAX prenyl protease 2
RCE1	Q9Y256	230	251	2	329	Chain	ID=PRO_0000194830;Note=CAAX prenyl protease 2
RCE1	Q9Y256	96	124	112	132	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RCE1	Q9Y256	230	251	229	249	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS2	O95864	206	248	1	444	Chain	ID=PRO_0000307101;Note=Fatty acid desaturase 2
FADS2	O95864	206	248	179	264	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FADS2	O95864	206	248	217	221	Motif	Note=Histidine box-2
FANCB	Q8NB91	368	399	2	859	Chain	ID=PRO_0000087181;Note=Fanconi anemia group B protein
FANCB	Q8NB91	368	399	2	859	Chain	ID=PRO_0000087181;Note=Fanconi anemia group B protein
FAT2	Q9NYQ8	3388	3436	19	4349	Chain	ID=PRO_0000004018;Note=Protocadherin Fat 2
FAT2	Q9NYQ8	1596	2947	19	4349	Chain	ID=PRO_0000004018;Note=Protocadherin Fat 2
FAT2	Q9NYQ8	1211	1315	19	4349	Chain	ID=PRO_0000004018;Note=Protocadherin Fat 2
FAT2	Q9NYQ8	3388	3436	19	4048	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	19	4048	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1211	1315	19	4048	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1211	1315	1138	1242	Domain	Note=Cadherin 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1211	1315	1243	1346	Domain	Note=Cadherin 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	1556	1660	Domain	Note=Cadherin 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	1661	1758	Domain	Note=Cadherin 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	1759	1872	Domain	Note=Cadherin 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	1969	2070	Domain	Note=Cadherin 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2071	2171	Domain	Note=Cadherin 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2172	2272	Domain	Note=Cadherin 19;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2273	2379	Domain	Note=Cadherin 20;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2380	2481	Domain	Note=Cadherin 21;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2482	2585	Domain	Note=Cadherin 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2586	2691	Domain	Note=Cadherin 23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2692	2797	Domain	Note=Cadherin 24;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2798	2906	Domain	Note=Cadherin 25;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	2907	3011	Domain	Note=Cadherin 26;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	3388	3436	3322	3426	Domain	Note=Cadherin 30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	3388	3436	3427	3531	Domain	Note=Cadherin 31;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
FAT2	Q9NYQ8	1596	2947	1904	1904	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	1998	1998	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2007	2007	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2165	2165	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2183	2183	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2325	2325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2368	2368	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2387	2387	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2430	2430	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2470	2470	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2547	2547	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2597	2597	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1596	2947	2654	2654	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	3388	3436	3430	3430	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT2	Q9NYQ8	1211	1315	1295	1295	Natural variant	ID=VAR_058286;Note=L->P;Dbxref=dbSNP:rs35640822
FAT2	Q9NYQ8	1596	2947	1895	1895	Natural variant	ID=VAR_055605;Note=R->W;Dbxref=dbSNP:rs34464977
FAT2	Q9NYQ8	1596	2947	2054	2054	Natural variant	ID=VAR_055606;Note=G->A;Dbxref=dbSNP:rs34493925
FAT2	Q9NYQ8	1596	2947	2428	2428	Natural variant	ID=VAR_061077;Note=F->S;Dbxref=dbSNP:rs6892335
FAT2	Q9NYQ8	1596	2947	2907	2907	Natural variant	ID=VAR_055607;Note=A->T;Dbxref=dbSNP:rs3734053
FAT2	Q9NYQ8	1211	1315	1287	1287	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAT2	Q9NYQ8	1211	1315	1303	1303	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
FIBCD1	Q8N539	24	184	1	461	Chain	ID=PRO_0000294315;Note=Fibrinogen C domain-containing protein 1
FIBCD1	Q8N539	24	184	1	461	Chain	ID=PRO_0000294315;Note=Fibrinogen C domain-containing protein 1
FIBCD1	Q8N539	24	184	1	33	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FIBCD1	Q8N539	24	184	1	33	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FIBCD1	Q8N539	24	184	34	54	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
FIBCD1	Q8N539	24	184	34	54	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
FIBCD1	Q8N539	24	184	55	461	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FIBCD1	Q8N539	24	184	55	461	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FIBCD1	Q8N539	24	184	1	158	Alternative sequence	ID=VSP_026618;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FIBCD1	Q8N539	24	184	1	158	Alternative sequence	ID=VSP_026618;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FIBCD1	Q8N539	24	184	79	79	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FIBCD1	Q8N539	24	184	79	79	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBLN7	Q53RD9	78	135	25	439	Chain	ID=PRO_0000313655;Note=Fibulin-7
FBLN7	Q53RD9	135	177	25	439	Chain	ID=PRO_0000313655;Note=Fibulin-7
FBLN7	Q53RD9	177	223	25	439	Chain	ID=PRO_0000313655;Note=Fibulin-7
FBLN7	Q53RD9	223	269	25	439	Chain	ID=PRO_0000313655;Note=Fibulin-7
FBLN7	Q53RD9	78	135	79	136	Domain	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
FBLN7	Q53RD9	135	177	79	136	Domain	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
FBLN7	Q53RD9	135	177	136	172	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN7	Q53RD9	223	269	224	269	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN7	Q53RD9	78	135	124	124	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBLN7	Q53RD9	78	135	81	121	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	78	135	107	134	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	135	177	140	151	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	135	177	145	160	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	135	177	162	171	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	223	269	228	244	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	223	269	240	253	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	223	269	255	268	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FBLN7	Q53RD9	135	177	136	269	Alternative sequence	ID=VSP_030085;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBLN7	Q53RD9	177	223	136	269	Alternative sequence	ID=VSP_030085;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBLN7	Q53RD9	223	269	136	269	Alternative sequence	ID=VSP_030085;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBLN7	Q53RD9	177	223	178	223	Alternative sequence	ID=VSP_030086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBLN7	Q53RD9	223	269	178	223	Alternative sequence	ID=VSP_030086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBLN7	Q53RD9	78	135	119	119	Natural variant	ID=VAR_037689;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs35586251,PMID:14702039
FBN1	P35555	2104	2126	45	2731	Chain	ID=PRO_0000007581;Note=Fibrillin-1;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10636927,ECO:0000305|PubMed:24982166;Dbxref=PMID:10636927,PMID:24982166
FBN1	P35555	1741	1765	45	2731	Chain	ID=PRO_0000007581;Note=Fibrillin-1;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10636927,ECO:0000305|PubMed:24982166;Dbxref=PMID:10636927,PMID:24982166
FBN1	P35555	245	287	45	2731	Chain	ID=PRO_0000007581;Note=Fibrillin-1;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10636927,ECO:0000305|PubMed:24982166;Dbxref=PMID:10636927,PMID:24982166
FBN1	P35555	115	147	45	2731	Chain	ID=PRO_0000007581;Note=Fibrillin-1;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10636927,ECO:0000305|PubMed:24982166;Dbxref=PMID:10636927,PMID:24982166
FBN1	P35555	115	147	115	146	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN1	P35555	115	147	147	178	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN1	P35555	245	287	246	287	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN1	P35555	1741	1765	1693	1748	Domain	Note=TB 7
FBN1	P35555	2104	2126	2059	2111	Domain	Note=TB 8
FBN1	P35555	245	287	45	450	Region	Note=N-terminal domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11461921;Dbxref=PMID:11461921
FBN1	P35555	115	147	45	450	Region	Note=N-terminal domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11461921;Dbxref=PMID:11461921
FBN1	P35555	245	287	119	329	Region	Note=Interaction with MFAP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26601954;Dbxref=PMID:26601954
FBN1	P35555	115	147	119	329	Region	Note=Interaction with MFAP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26601954;Dbxref=PMID:26601954
FBN1	P35555	2104	2126	1528	2731	Region	Note=C-terminal domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11461921;Dbxref=PMID:11461921
FBN1	P35555	1741	1765	1528	2731	Region	Note=C-terminal domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11461921;Dbxref=PMID:11461921
FBN1	P35555	115	147	119	129	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:24035709;Dbxref=PMID:24035709
FBN1	P35555	115	147	123	134	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:24035709;Dbxref=PMID:24035709
FBN1	P35555	115	147	136	145	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:24035709;Dbxref=PMID:24035709
FBN1	P35555	245	287	250	262	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN1	P35555	245	287	257	271	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN1	P35555	245	287	273	286	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN1	P35555	2104	2126	2085	2111	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:9362480;Dbxref=PMID:9362480
FBN1	P35555	115	147	115	115	Natural variant	ID=VAR_017970;Note=In ECTOL1. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12203992;Dbxref=PMID:12203992
FBN1	P35555	115	147	122	122	Natural variant	ID=VAR_002277;Note=In MFS. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11700157,ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:8040326,ECO:0000269|PubMed:9452085;Dbxref=dbSNP:rs137854467,PMID:11700157,PMID:17657824,PMID:8040326,PMID:9452085
FBN1	P35555	115	147	123	123	Natural variant	ID=VAR_023860;Note=In MFS. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16222657,ECO:0000269|PubMed:18435798;Dbxref=PMID:16222657,PMID:18435798
FBN1	P35555	115	147	127	127	Natural variant	ID=VAR_075990;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	115	147	129	129	Natural variant	ID=VAR_002278;Note=In MFS%3B severe neonatal. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19533785,ECO:0000269|PubMed:7611299;Dbxref=PMID:19533785,PMID:7611299
FBN1	P35555	115	147	133	133	Natural variant	ID=VAR_055723;Note=H->Q;Dbxref=dbSNP:rs363850
FBN1	P35555	115	147	136	136	Natural variant	ID=VAR_075991;Note=In MFS. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	215	2871	Natural variant	ID=VAR_075997;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	215	2871	Natural variant	ID=VAR_075997;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	245	287	215	2871	Natural variant	ID=VAR_075997;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	248	2871	Natural variant	ID=VAR_075999;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	248	2871	Natural variant	ID=VAR_075999;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	245	287	248	2871	Natural variant	ID=VAR_075999;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	348	2871	Natural variant	ID=VAR_076000;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	1741	1765	348	2871	Natural variant	ID=VAR_076000;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	351	2871	Natural variant	ID=VAR_076001;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	351	2871	Natural variant	ID=VAR_076001;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	364	2871	Natural variant	ID=VAR_076002;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	364	2871	Natural variant	ID=VAR_076002;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	366	2871	Natural variant	ID=VAR_076005;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	366	2871	Natural variant	ID=VAR_076005;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	429	2871	Natural variant	ID=VAR_076006;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12402346,ECO:0000269|PubMed:18435798;Dbxref=PMID:12402346,PMID:18435798
FBN1	P35555	1741	1765	429	2871	Natural variant	ID=VAR_076006;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12402346,ECO:0000269|PubMed:18435798;Dbxref=PMID:12402346,PMID:18435798
FBN1	P35555	2104	2126	565	2871	Natural variant	ID=VAR_076012;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	565	2871	Natural variant	ID=VAR_076012;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	653	2871	Natural variant	ID=VAR_076019;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	653	2871	Natural variant	ID=VAR_076019;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	752	2871	Natural variant	ID=VAR_076024;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	752	2871	Natural variant	ID=VAR_076024;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	861	2871	Natural variant	ID=VAR_076027;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:19533785;Dbxref=PMID:17657824,PMID:19533785
FBN1	P35555	1741	1765	861	2871	Natural variant	ID=VAR_076027;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:19533785;Dbxref=PMID:17657824,PMID:19533785
FBN1	P35555	2104	2126	921	2871	Natural variant	ID=VAR_076033;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19533785;Dbxref=PMID:19533785
FBN1	P35555	1741	1765	921	2871	Natural variant	ID=VAR_076033;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19533785;Dbxref=PMID:19533785
FBN1	P35555	2104	2126	966	2871	Natural variant	ID=VAR_076036;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	966	2871	Natural variant	ID=VAR_076036;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	988	2871	Natural variant	ID=VAR_076039;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	988	2871	Natural variant	ID=VAR_076039;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	994	2871	Natural variant	ID=VAR_076040;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	994	2871	Natural variant	ID=VAR_076040;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	1086	2871	Natural variant	ID=VAR_076047;Note=In ECTOL1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	1086	2871	Natural variant	ID=VAR_076047;Note=In ECTOL1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	1125	2871	Natural variant	ID=VAR_076050;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:18435798;Dbxref=PMID:17657824,PMID:18435798
FBN1	P35555	1741	1765	1125	2871	Natural variant	ID=VAR_076050;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:18435798;Dbxref=PMID:17657824,PMID:18435798
FBN1	P35555	2104	2126	1136	2871	Natural variant	ID=VAR_076052;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	1741	1765	1136	2871	Natural variant	ID=VAR_076052;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	1140	2871	Natural variant	ID=VAR_076054;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	1140	2871	Natural variant	ID=VAR_076054;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	1534	2871	Natural variant	ID=VAR_076070;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	1741	1765	1534	2871	Natural variant	ID=VAR_076070;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	1539	2871	Natural variant	ID=VAR_076071;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18435798,ECO:0000269|PubMed:22772377;Dbxref=PMID:18435798,PMID:22772377
FBN1	P35555	1741	1765	1539	2871	Natural variant	ID=VAR_076071;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18435798,ECO:0000269|PubMed:22772377;Dbxref=PMID:18435798,PMID:22772377
FBN1	P35555	2104	2126	1541	2871	Natural variant	ID=VAR_076072;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12161601,ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:18435798;Dbxref=PMID:12161601,PMID:17657824,PMID:18435798
FBN1	P35555	1741	1765	1541	2871	Natural variant	ID=VAR_076072;Note=In MFS. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12161601,ECO:0000269|PubMed:17657824,ECO:0000269|PubMed:18435798;Dbxref=PMID:12161601,PMID:17657824,PMID:18435798
FBN1	P35555	2104	2126	1644	2871	Natural variant	ID=VAR_076076;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	1741	1765	1644	2871	Natural variant	ID=VAR_076076;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	1735	2871	Natural variant	ID=VAR_076082;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	1741	1765	1735	2871	Natural variant	ID=VAR_076082;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	1741	1765	1750	1750	Natural variant	ID=VAR_066540;Note=In ACMICD. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21683322;Dbxref=PMID:21683322
FBN1	P35555	1741	1765	1758	1758	Natural variant	ID=VAR_066541;Note=In ACMICD. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21683322;Dbxref=PMID:21683322
FBN1	P35555	1741	1765	1762	1762	Natural variant	ID=VAR_066542;Note=In GPHYSD2. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21683322;Dbxref=PMID:21683322
FBN1	P35555	2104	2126	1790	2871	Natural variant	ID=VAR_076084;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19533785;Dbxref=PMID:19533785
FBN1	P35555	2104	2126	1796	2871	Natural variant	ID=VAR_076086;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	2053	2871	Natural variant	ID=VAR_076108;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	2057	2871	Natural variant	ID=VAR_076109;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	2062	2871	Natural variant	ID=VAR_076110;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	2064	2871	Natural variant	ID=VAR_076111;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18435798;Dbxref=PMID:18435798
FBN1	P35555	2104	2126	2081	2871	Natural variant	ID=VAR_076112;Note=In MFS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22772377;Dbxref=PMID:22772377
FBN1	P35555	2104	2126	2105	2105	Natural variant	ID=VAR_076115;Note=Probable disease-associated mutation found in a patient with Marfan-like syndrome. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	2104	2126	2111	2111	Natural variant	ID=VAR_018029;Note=In MFS. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11826022;Dbxref=dbSNP:rs363815,PMID:11826022
FBN1	P35555	2104	2126	2111	2111	Natural variant	ID=VAR_002334;Note=In MFS. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9338581;Dbxref=PMID:9338581
FBN1	P35555	2104	2126	2113	2113	Natural variant	ID=VAR_055732;Note=Y->F;Dbxref=dbSNP:rs363816
FBN1	P35555	2104	2126	2118	2118	Natural variant	ID=VAR_076116;Note=In MFS. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17657824;Dbxref=PMID:17657824
FBN1	P35555	115	147	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M74
FBN1	P35555	115	147	128	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	115	147	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	115	147	142	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M74
FBN1	P35555	245	287	244	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	245	287	249	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	245	287	253	255	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	245	287	258	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	245	287	268	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	245	287	281	284	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MS9
FBN1	P35555	2104	2126	2105	2110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1APJ
EFEMP1	Q12805	253	293	18	493	Chain	ID=PRO_0000007570;Note=EGF-containing fibulin-like extracellular matrix protein 1
EFEMP1	Q12805	213	253	18	493	Chain	ID=PRO_0000007570;Note=EGF-containing fibulin-like extracellular matrix protein 1
EFEMP1	Q12805	253	293	18	493	Chain	ID=PRO_0000007570;Note=EGF-containing fibulin-like extracellular matrix protein 1
EFEMP1	Q12805	213	253	18	493	Chain	ID=PRO_0000007570;Note=EGF-containing fibulin-like extracellular matrix protein 1
EFEMP1	Q12805	213	253	173	213	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	173	213	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	214	253	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	214	253	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	214	253	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	214	253	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	254	293	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	254	293	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	259	493	Region	Note=Mediates interaction with TIMP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15123717;Dbxref=PMID:15123717
EFEMP1	Q12805	253	293	259	493	Region	Note=Mediates interaction with TIMP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15123717;Dbxref=PMID:15123717
EFEMP1	Q12805	213	253	249	249	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EFEMP1	Q12805	213	253	249	249	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EFEMP1	Q12805	213	253	218	228	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	218	228	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	224	237	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	224	237	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	239	252	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	213	253	239	252	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	258	268	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	258	268	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	264	277	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	264	277	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	279	292	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	279	292	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EFEMP1	Q12805	253	293	214	293	Alternative sequence	ID=VSP_054373;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFEMP1	Q12805	213	253	214	293	Alternative sequence	ID=VSP_054373;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFEMP1	Q12805	253	293	214	293	Alternative sequence	ID=VSP_054373;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFEMP1	Q12805	213	253	214	293	Alternative sequence	ID=VSP_054373;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EFEMP1	Q12805	213	253	220	220	Natural variant	ID=VAR_009512;Note=I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10369267;Dbxref=dbSNP:rs748965004,PMID:10369267
EFEMP1	Q12805	213	253	220	220	Natural variant	ID=VAR_009512;Note=I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10369267;Dbxref=dbSNP:rs748965004,PMID:10369267
FBXO38	Q6PIJ6	639	884	1	1188	Chain	ID=PRO_0000119933;Note=F-box only protein 38
FBXO38	Q6PIJ6	639	884	736	736	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
FBXO38	Q6PIJ6	639	884	740	740	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FBXO38	Q6PIJ6	639	884	640	809	Alternative sequence	ID=VSP_011448;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBXO38	Q6PIJ6	639	884	810	884	Alternative sequence	ID=VSP_011449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
FBXO38	Q6PIJ6	639	884	775	776	Sequence conflict	Note=RC->DA;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCRL2	Q96LA5	464	486	20	508	Chain	ID=PRO_0000014761;Note=Fc receptor-like protein 2
FCRL2	Q96LA5	294	387	20	508	Chain	ID=PRO_0000014761;Note=Fc receptor-like protein 2
FCRL2	Q96LA5	103	198	20	508	Chain	ID=PRO_0000014761;Note=Fc receptor-like protein 2
FCRL2	Q96LA5	294	387	20	401	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL2	Q96LA5	103	198	20	401	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL2	Q96LA5	464	486	423	508	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL2	Q96LA5	103	198	109	187	Domain	Note=Ig-like C2-type 2
FCRL2	Q96LA5	294	387	300	387	Domain	Note=Ig-like C2-type 4
FCRL2	Q96LA5	464	486	460	465	Motif	Note=ITIM motif 2
FCRL2	Q96LA5	464	486	472	477	Motif	Note=ITIM motif 3
FCRL2	Q96LA5	294	387	343	343	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL2	Q96LA5	294	387	355	355	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL2	Q96LA5	294	387	365	365	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL2	Q96LA5	103	198	128	177	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL2	Q96LA5	294	387	321	368	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL2	Q96LA5	103	198	1	253	Alternative sequence	ID=VSP_014111;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11162587,ECO:0000303|PubMed:12037601,ECO:0000303|PubMed:15489334;Dbxref=PMID:11162587,PMID:12037601,PMID:15489334
FCRL2	Q96LA5	294	387	104	387	Alternative sequence	ID=VSP_014113;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCRL2	Q96LA5	103	198	104	387	Alternative sequence	ID=VSP_014113;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCRL2	Q96LA5	294	387	254	295	Alternative sequence	ID=VSP_014112;Note=In isoform 2%2C isoform 3 and isoform 4. RSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRI->MWEWKICNSHGARPFAEPAGWEFVNLLRHHKSFLIAPLCLSV;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11162587,ECO:0000303|PubMed:12037601,ECO:0000303|PubMed:15489334;Dbxref=PMID:11162587,PMID:12037601,PMID:15489334
FCRL2	Q96LA5	464	486	398	508	Alternative sequence	ID=VSP_014115;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162587;Dbxref=PMID:11162587
FCRL2	Q96LA5	464	486	446	508	Alternative sequence	ID=VSP_014117;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11162587;Dbxref=PMID:11162587
FCRL2	Q96LA5	464	486	465	486	Alternative sequence	ID=VSP_014118;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FCRL5	Q96RD9	838	877	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	467	560	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	467	560	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	281	374	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	281	374	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	17	102	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
FCRL5	Q96RD9	838	877	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	467	560	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	467	560	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	281	374	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	281	374	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	17	102	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	838	877	852	872	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	838	877	873	977	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL5	Q96RD9	17	102	23	101	Domain	Note=Ig-like C2-type 1
FCRL5	Q96RD9	281	374	287	374	Domain	Note=Ig-like C2-type 3
FCRL5	Q96RD9	281	374	287	374	Domain	Note=Ig-like C2-type 3
FCRL5	Q96RD9	467	560	473	556	Domain	Note=Ig-like C2-type 5
FCRL5	Q96RD9	467	560	473	556	Domain	Note=Ig-like C2-type 5
FCRL5	Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
FCRL5	Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
FCRL5	Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
FCRL5	Q96RD9	17	102	44	85	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	281	374	308	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	281	374	308	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	467	560	494	541	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	467	560	494	541	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL5	Q96RD9	838	877	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	467	560	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	467	560	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	281	374	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	281	374	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
FCRL5	Q96RD9	838	877	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	467	560	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	467	560	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	281	374	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	281	374	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	838	877	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	838	877	760	977	Alternative sequence	ID=VSP_017386;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11290337;Dbxref=PMID:11290337
FCRL5	Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
FCRL5	Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
FCRL5	Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
FCRL5	Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCRL5	Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCRL5	Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBRSL1	Q9HCM7	163	193	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	193	205	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	205	215	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	477	496	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	496	528	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	654	680	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	680	708	1	1045	Chain	ID=PRO_0000321962;Note=Fibrosin-1-like protein
FBRSL1	Q9HCM7	477	496	263	517	Compositional bias	Note=Pro-rich
FBRSL1	Q9HCM7	496	528	263	517	Compositional bias	Note=Pro-rich
FCHO2	Q0JRZ9	42	66	1	810	Chain	ID=PRO_0000266005;Note=F-BAR domain only protein 2
FCHO2	Q0JRZ9	114	165	1	810	Chain	ID=PRO_0000266005;Note=F-BAR domain only protein 2
FCHO2	Q0JRZ9	165	200	1	810	Chain	ID=PRO_0000266005;Note=F-BAR domain only protein 2
FCHO2	Q0JRZ9	200	233	1	810	Chain	ID=PRO_0000266005;Note=F-BAR domain only protein 2
FCHO2	Q0JRZ9	42	66	3	250	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO2	Q0JRZ9	114	165	3	250	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO2	Q0JRZ9	165	200	3	250	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO2	Q0JRZ9	200	233	3	250	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FCHO2	Q0JRZ9	42	66	3	274	Region	Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
FCHO2	Q0JRZ9	114	165	3	274	Region	Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
FCHO2	Q0JRZ9	165	200	3	274	Region	Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
FCHO2	Q0JRZ9	200	233	3	274	Region	Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
FCHO2	Q0JRZ9	114	165	87	156	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FCHO2	Q0JRZ9	114	165	147	147	Disulfide bond	Note=Interchain (with C-273);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17540576;Dbxref=PMID:17540576
FCHO2	Q0JRZ9	165	200	200	232	Alternative sequence	ID=VSP_044812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FCHO2	Q0JRZ9	200	233	200	232	Alternative sequence	ID=VSP_044812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FCHO2	Q0JRZ9	42	66	17	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O
FCHO2	Q0JRZ9	114	165	73	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O
FCHO2	Q0JRZ9	114	165	120	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O
FCHO2	Q0JRZ9	114	165	160	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O
FCHO2	Q0JRZ9	165	200	160	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O
FCHO2	Q0JRZ9	200	233	160	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O
PDAP1	Q13442	35	71	1	181	Chain	ID=PRO_0000083897;Note=28 kDa heat- and acid-stable phosphoprotein
PDAP1	Q13442	35	71	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18318008,PMID:18669648,PMID:20068231,PMID:24275569
PDAP1	Q13442	35	71	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18088087,PMID:18318008,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PDAP1	Q13442	35	71	63	63	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:17487921,PMID:18088087,PMID:18318008,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PDAP1	Q13442	35	71	70	70	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHX2
PDAP1	Q13442	35	71	52	52	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PDAP1	Q13442	35	71	67	67	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXOC6	Q8TAG9	91	107	1	804	Chain	ID=PRO_0000118951;Note=Exocyst complex component 6
EXOC6	Q8TAG9	221	273	1	804	Chain	ID=PRO_0000118951;Note=Exocyst complex component 6
EXOC6	Q8TAG9	273	296	1	804	Chain	ID=PRO_0000118951;Note=Exocyst complex component 6
EXOC6	Q8TAG9	380	404	1	804	Chain	ID=PRO_0000118951;Note=Exocyst complex component 6
EXOC6	Q8TAG9	591	651	1	804	Chain	ID=PRO_0000118951;Note=Exocyst complex component 6
EXOC6	Q8TAG9	380	404	396	396	Natural variant	ID=VAR_044522;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1326331,PMID:15489334
FAM169A	Q9Y6X4	163	223	1	670	Chain	ID=PRO_0000320587;Note=Soluble lamin-associated protein of 75 kDa
FAM169A	Q9Y6X4	163	223	128	670	Alternative sequence	ID=VSP_031671;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FAM102B	Q5T8I3	86	96	1	360	Chain	ID=PRO_0000236180;Note=Protein FAM102B
FAM102B	Q5T8I3	96	135	1	360	Chain	ID=PRO_0000236180;Note=Protein FAM102B
FAM102B	Q5T8I3	86	96	1	142	Domain	Note=C2 NT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01186
FAM102B	Q5T8I3	96	135	1	142	Domain	Note=C2 NT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01186
FAM160B2	Q86V87	99	134	1	743	Chain	ID=PRO_0000284645;Note=Protein FAM160B2
FAM160B2	Q86V87	617	664	1	743	Chain	ID=PRO_0000284645;Note=Protein FAM160B2
FBP1	P09467	189	235	2	338	Chain	ID=PRO_0000200498;Note=Fructose-1%2C6-bisphosphatase 1
FBP1	P09467	142	189	2	338	Chain	ID=PRO_0000200498;Note=Fructose-1%2C6-bisphosphatase 1
FBP1	P09467	111	142	2	338	Chain	ID=PRO_0000200498;Note=Fructose-1%2C6-bisphosphatase 1
FBP1	P09467	189	235	2	338	Chain	ID=PRO_0000200498;Note=Fructose-1%2C6-bisphosphatase 1
FBP1	P09467	142	189	2	338	Chain	ID=PRO_0000200498;Note=Fructose-1%2C6-bisphosphatase 1
FBP1	P09467	111	142	2	338	Chain	ID=PRO_0000200498;Note=Fructose-1%2C6-bisphosphatase 1
FBP1	P09467	111	142	113	114	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FTA,ECO:0000269|PubMed:7809062;Dbxref=PMID:7809062
FBP1	P09467	111	142	113	114	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FTA,ECO:0000269|PubMed:7809062;Dbxref=PMID:7809062
FBP1	P09467	111	142	122	125	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	111	142	122	125	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	189	235	213	216	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	189	235	213	216	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	111	142	119	119	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	111	142	119	119	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	111	142	119	119	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FHY
FBP1	P09467	111	142	119	119	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FHY
FBP1	P09467	111	142	121	121	Metal binding	Note=Magnesium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	111	142	121	121	Metal binding	Note=Magnesium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00636
FBP1	P09467	111	142	122	122	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FHY
FBP1	P09467	111	142	122	122	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FHY
FBP1	P09467	111	142	141	141	Binding site	Note=AMP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FTA,ECO:0000269|PubMed:7809062;Dbxref=PMID:7809062
FBP1	P09467	111	142	141	141	Binding site	Note=AMP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FTA,ECO:0000269|PubMed:7809062;Dbxref=PMID:7809062
FBP1	P09467	142	189	151	151	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXD6
FBP1	P09467	142	189	151	151	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXD6
FBP1	P09467	189	235	216	216	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXD6
FBP1	P09467	189	235	216	216	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXD6
FBP1	P09467	142	189	158	158	Natural variant	ID=VAR_075492;Note=In FBP1D%3B unknown pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25601412;Dbxref=dbSNP:rs766005419,PMID:25601412
FBP1	P09467	142	189	158	158	Natural variant	ID=VAR_075492;Note=In FBP1D%3B unknown pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25601412;Dbxref=dbSNP:rs766005419,PMID:25601412
FBP1	P09467	142	189	164	164	Natural variant	ID=VAR_002380;Note=In FBP1D. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9382095;Dbxref=dbSNP:rs121918188,PMID:9382095
FBP1	P09467	142	189	164	164	Natural variant	ID=VAR_002380;Note=In FBP1D. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9382095;Dbxref=dbSNP:rs121918188,PMID:9382095
FBP1	P09467	142	189	177	177	Natural variant	ID=VAR_002381;Note=In FBP1D. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9382095;Dbxref=dbSNP:rs121918189,PMID:9382095
FBP1	P09467	142	189	177	177	Natural variant	ID=VAR_002381;Note=In FBP1D. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9382095;Dbxref=dbSNP:rs121918189,PMID:9382095
FBP1	P09467	189	235	194	194	Natural variant	ID=VAR_038812;Note=In FBP1D. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12126934;Dbxref=dbSNP:rs121918191,PMID:12126934
FBP1	P09467	189	235	194	194	Natural variant	ID=VAR_038812;Note=In FBP1D. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12126934;Dbxref=dbSNP:rs121918191,PMID:12126934
FBP1	P09467	189	235	218	218	Natural variant	ID=VAR_022212;Note=R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10222032,ECO:0000269|PubMed:2842796,ECO:0000269|PubMed:7558035,ECO:0000269|PubMed:8135811,ECO:0000269|PubMed:8387495,ECO:0000269|Ref.6,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1769259,PMID:10222032,PMID:2842796,PMID:7558035,PMID:8135811,PMID:8387495
FBP1	P09467	189	235	218	218	Natural variant	ID=VAR_022212;Note=R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10222032,ECO:0000269|PubMed:2842796,ECO:0000269|PubMed:7558035,ECO:0000269|PubMed:8135811,ECO:0000269|PubMed:8387495,ECO:0000269|Ref.6,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1769259,PMID:10222032,PMID:2842796,PMID:7558035,PMID:8135811,PMID:8387495
FBP1	P09467	189	235	233	233	Natural variant	ID=VAR_022213;Note=F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7;Dbxref=dbSNP:rs2297085
FBP1	P09467	189	235	233	233	Natural variant	ID=VAR_022213;Note=F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7;Dbxref=dbSNP:rs2297085
FBP1	P09467	111	142	119	119	Mutagenesis	Note=Reduced activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8387495;Dbxref=PMID:8387495
FBP1	P09467	111	142	119	119	Mutagenesis	Note=Reduced activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8387495;Dbxref=PMID:8387495
FBP1	P09467	111	142	122	122	Mutagenesis	Note=Reduced activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8387495;Dbxref=PMID:8387495
FBP1	P09467	111	142	122	122	Mutagenesis	Note=Reduced activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8387495;Dbxref=PMID:8387495
FBP1	P09467	189	235	215	215	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBP1	P09467	189	235	215	215	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBP1	P09467	189	235	215	215	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBP1	P09467	189	235	215	215	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBP1	P09467	111	142	111	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	111	142	111	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	111	142	124	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	111	142	124	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	111	142	133	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	111	142	133	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	144	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y5L
FBP1	P09467	142	189	144	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y5L
FBP1	P09467	142	189	150	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	150	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	161	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	161	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	181	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	181	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	189	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	189	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	189	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	142	189	189	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	193	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	193	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	208	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	208	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	214	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	214	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJK
FBP1	P09467	189	235	235	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y5K
FBP1	P09467	189	235	235	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y5K
FAM171A1	Q5VUB5	192	251	22	890	Chain	ID=PRO_0000274263;Note=Protein FAM171A1
FAM171A1	Q5VUB5	139	192	22	890	Chain	ID=PRO_0000274263;Note=Protein FAM171A1
FAM171A1	Q5VUB5	108	139	22	890	Chain	ID=PRO_0000274263;Note=Protein FAM171A1
FAM171A1	Q5VUB5	192	251	22	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM171A1	Q5VUB5	139	192	22	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM171A1	Q5VUB5	108	139	22	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM171A1	Q5VUB5	139	192	159	159	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
FAM171A1	Q5VUB5	139	192	190	190	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM171A1	Q5VUB5	192	251	194	194	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM171A1	Q5VUB5	108	139	118	118	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM185A	Q8N0U4	187	218	1	392	Chain	ID=PRO_0000321830;Note=Protein FAM185A
FAM185A	Q8N0U4	264	278	1	392	Chain	ID=PRO_0000321830;Note=Protein FAM185A
FAM185A	Q8N0U4	310	355	1	392	Chain	ID=PRO_0000321830;Note=Protein FAM185A
FAM185A	Q8N0U4	187	218	71	187	Alternative sequence	ID=VSP_037078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM185A	Q8N0U4	187	218	145	392	Alternative sequence	ID=VSP_031804;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM185A	Q8N0U4	264	278	145	392	Alternative sequence	ID=VSP_031804;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM185A	Q8N0U4	310	355	145	392	Alternative sequence	ID=VSP_031804;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PFKFB4	Q16877	329	364	1	469	Chain	ID=PRO_0000179970;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 4
PFKFB4	Q16877	280	329	1	469	Chain	ID=PRO_0000179970;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 4
PFKFB4	Q16877	151	170	1	469	Chain	ID=PRO_0000179970;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 4
PFKFB4	Q16877	151	170	168	173	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875
PFKFB4	Q16877	329	364	348	351	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953
PFKFB4	Q16877	151	170	1	249	Region	Note=6-phosphofructo-2-kinase
PFKFB4	Q16877	329	364	250	469	Region	Note=Fructose-2%2C6-bisphosphatase
PFKFB4	Q16877	280	329	250	469	Region	Note=Fructose-2%2C6-bisphosphatase
PFKFB4	Q16877	151	170	159	159	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255
PFKFB4	Q16877	280	329	326	326	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953
PFKFB4	Q16877	280	329	306	306	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875
PFKFB4	Q16877	329	364	337	337	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953
PFKFB4	Q16877	329	364	351	351	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953
PFKFB4	Q16877	329	364	355	355	Binding site	Note=Fructose 2%2C6-bisphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953
PFKFB4	Q16877	329	364	330	364	Alternative sequence	ID=VSP_056530;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15474002;Dbxref=PMID:15474002
PFKFB1	P16118	409	430	2	471	Chain	ID=PRO_0000179960;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 1
PFKFB1	P16118	409	430	251	471	Region	Note=Fructose-2%2C6-bisphosphatase
PFKFB1	P16118	409	430	430	430	Binding site	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12379646;Dbxref=PMID:12379646
PFKFB1	P16118	409	430	409	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K6M
PFKFB1	P16118	409	430	412	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K6M
PFKFB1	P16118	409	430	421	427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K6M
PFKFB1	P16118	409	430	429	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K6M
FAM45A	Q8TCE6	231	267	1	357	Chain	ID=PRO_0000187034;Note=Protein FAM45A
FAM45A	Q8TCE6	231	267	165	299	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
FAM45A	Q8TCE6	231	267	267	267	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM98C	Q17RN3	185	211	1	349	Chain	ID=PRO_0000282428;Note=Protein FAM98C
FAM98C	Q17RN3	211	250	1	349	Chain	ID=PRO_0000282428;Note=Protein FAM98C
FAM98C	Q17RN3	250	306	1	349	Chain	ID=PRO_0000282428;Note=Protein FAM98C
FAM98C	Q17RN3	185	211	186	211	Alternative sequence	ID=VSP_024142;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM98C	Q17RN3	211	250	186	211	Alternative sequence	ID=VSP_024142;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM98C	Q17RN3	250	306	251	306	Alternative sequence	ID=VSP_024143;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM98C	Q17RN3	211	250	240	240	Natural variant	ID=VAR_049030;Note=T->K;Dbxref=dbSNP:rs3745962
F9	P00740	92	130	47	461	Chain	ID=PRO_0000027756;Note=Coagulation factor IX
F9	P00740	130	173	47	461	Chain	ID=PRO_0000027756;Note=Coagulation factor IX
F9	P00740	92	130	47	191	Chain	ID=PRO_0000027757;Note=Coagulation factor IXa light chain
F9	P00740	130	173	47	191	Chain	ID=PRO_0000027757;Note=Coagulation factor IXa light chain
F9	P00740	92	130	47	92	Domain	Note=Gla;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00463
F9	P00740	92	130	93	129	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
F9	P00740	92	130	130	171	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
F9	P00740	130	173	130	171	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
F9	P00740	92	130	93	93	Metal binding	Note=Calcium 7;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000269|PubMed:7606779;Dbxref=PMID:7606779
F9	P00740	92	130	94	94	Metal binding	Note=Calcium 7%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000269|PubMed:7606779;Dbxref=PMID:7606779
F9	P00740	92	130	96	96	Metal binding	Note=Calcium 7;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000269|PubMed:7606779;Dbxref=PMID:7606779
F9	P00740	92	130	110	110	Metal binding	Note=Calcium 7;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000269|PubMed:7606779;Dbxref=PMID:7606779
F9	P00740	92	130	111	111	Metal binding	Note=Calcium 7%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000269|PubMed:7606779;Dbxref=PMID:7606779
F9	P00740	92	130	110	110	Modified residue	Note=(3R)-3-hydroxyaspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6688526;Dbxref=PMID:6688526
F9	P00740	92	130	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.28
F9	P00740	92	130	99	99	Glycosylation	ID=CAR_000009;Note=O-linked (Glc...) serine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2129367,ECO:0000269|PubMed:21949356,ECO:0000269|PubMed:2511201,ECO:0000269|PubMed:25456591;Dbxref=PMID:2129367,PMID:21949356,PMID:2511201,PMID:25456591
F9	P00740	92	130	99	99	Glycosylation	Note=O-linked (Xyl...) serine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2129367,ECO:0000269|PubMed:21949356,ECO:0000269|PubMed:2511201;Dbxref=PMID:2129367,PMID:21949356,PMID:2511201
F9	P00740	92	130	107	107	Glycosylation	ID=CAR_000010;Note=O-linked (Fuc...) serine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1517205,ECO:0000269|PubMed:25456591;Dbxref=PMID:1517205,PMID:25456591
F9	P00740	92	130	97	108	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000244|PDB:1IXA,ECO:0000269|PubMed:1304885,ECO:0000269|PubMed:7606779;Dbxref=PMID:1304885,PMID:7606779
F9	P00740	92	130	102	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000244|PDB:1IXA,ECO:0000269|PubMed:1304885,ECO:0000269|PubMed:7606779;Dbxref=PMID:1304885,PMID:7606779
F9	P00740	92	130	119	128	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EDM,ECO:0000244|PDB:1IXA,ECO:0000269|PubMed:1304885,ECO:0000269|PubMed:7606779;Dbxref=PMID:1304885,PMID:7606779
F9	P00740	130	173	134	145	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1RFN,ECO:0000244|PDB:2WPH,ECO:0000244|PDB:2WPI,ECO:0000244|PDB:2WPJ,ECO:0000244|PDB:2WPK,ECO:0000244|PDB:2WPL,ECO:0000244|PDB:2WPM,ECO:0000244|PDB:3KCG,ECO:0000244|PDB:3LC3,ECO:0000244|PDB:3LC5,ECO:0000269|PubMed:20004170,ECO:0000269|PubMed:20080729,ECO:0000269|PubMed:20121197,ECO:0000269|PubMed:20121198;Dbxref=PMID:20004170,PMID:20080729,PMID:20121197,PMID:20121198
F9	P00740	130	173	141	155	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1RFN,ECO:0000244|PDB:2WPH,ECO:0000244|PDB:2WPI,ECO:0000244|PDB:2WPJ,ECO:0000244|PDB:2WPK,ECO:0000244|PDB:2WPL,ECO:0000244|PDB:2WPM,ECO:0000244|PDB:3KCG,ECO:0000244|PDB:3LC3,ECO:0000244|PDB:3LC5,ECO:0000269|PubMed:20004170,ECO:0000269|PubMed:20080729,ECO:0000269|PubMed:20121197,ECO:0000269|PubMed:20121198;Dbxref=PMID:20004170,PMID:20080729,PMID:20121197,PMID:20121198
F9	P00740	130	173	157	170	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1RFN,ECO:0000244|PDB:2WPH,ECO:0000244|PDB:2WPI,ECO:0000244|PDB:2WPJ,ECO:0000244|PDB:2WPK,ECO:0000244|PDB:2WPL,ECO:0000244|PDB:2WPM,ECO:0000244|PDB:3KCG,ECO:0000244|PDB:3LC3,ECO:0000244|PDB:3LC5,ECO:0000269|PubMed:20004170,ECO:0000269|PubMed:20080729,ECO:0000269|PubMed:20121197,ECO:0000269|PubMed:20121198;Dbxref=PMID:20004170,PMID:20080729,PMID:20121197,PMID:20121198
F9	P00740	92	130	93	130	Alternative sequence	ID=VSP_047689;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
F9	P00740	130	173	93	130	Alternative sequence	ID=VSP_047689;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
F9	P00740	92	130	93	93	Natural variant	ID=VAR_006544;Note=In HEMB%3B moderate%3B Alabama. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3790720;Dbxref=dbSNP:rs137852230,PMID:3790720
F9	P00740	92	130	96	96	Natural variant	ID=VAR_006545;Note=In HEMB%3B severe%3B New London. Q->P;Dbxref=dbSNP:rs137852231
F9	P00740	92	130	97	97	Natural variant	ID=VAR_006546;Note=In HEMB. C->S
F9	P00740	92	130	101	101	Natural variant	ID=VAR_006547;Note=In HEMB. P->R
F9	P00740	92	130	102	102	Natural variant	ID=VAR_006548;Note=In HEMB%3B severe%3B Basel. C->R
F9	P00740	92	130	106	106	Natural variant	ID=VAR_017346;Note=In HEMB. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588353;Dbxref=PMID:12588353
F9	P00740	92	130	106	106	Natural variant	ID=VAR_006549;Note=In HEMB%3B mild%3B Durham. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2472424,ECO:0000269|PubMed:9600455;Dbxref=dbSNP:rs137852233,PMID:2472424,PMID:9600455
F9	P00740	92	130	108	108	Natural variant	ID=VAR_006550;Note=In HEMB. C->S
F9	P00740	92	130	110	110	Natural variant	ID=VAR_006551;Note=In HEMB%3B severe%3B Oxford-D1. D->N;Dbxref=dbSNP:rs137852274
F9	P00740	92	130	112	112	Natural variant	ID=VAR_006552;Note=In HEMB. I->S
F9	P00740	92	130	113	113	Natural variant	ID=VAR_006553;Note=In HEMB%3B mild. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9222764;Dbxref=PMID:9222764
F9	P00740	92	130	115	115	Natural variant	ID=VAR_006554;Note=In HEMB%3B severe. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600455;Dbxref=PMID:9600455
F9	P00740	92	130	119	119	Natural variant	ID=VAR_006555;Note=In HEMB%3B severe. C->F
F9	P00740	92	130	119	119	Natural variant	ID=VAR_006556;Note=In HEMB%3B Iran. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452115;Dbxref=PMID:9452115
F9	P00740	92	130	124	124	Natural variant	ID=VAR_017347;Note=In HEMB. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588353;Dbxref=PMID:12588353
F9	P00740	92	130	125	125	Natural variant	ID=VAR_006557;Note=In HEMB. G->E
F9	P00740	92	130	125	125	Natural variant	ID=VAR_017348;Note=In HEMB. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12604421;Dbxref=PMID:12604421
F9	P00740	92	130	125	125	Natural variant	ID=VAR_006558;Note=In HEMB. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12604421;Dbxref=PMID:12604421
F9	P00740	92	130	129	130	Natural variant	ID=VAR_006559;Note=In HEMB. Missing
F9	P00740	130	173	129	130	Natural variant	ID=VAR_006559;Note=In HEMB. Missing
F9	P00740	130	173	134	134	Natural variant	ID=VAR_017349;Note=In HEMB. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588353;Dbxref=PMID:12588353
F9	P00740	130	173	136	136	Natural variant	ID=VAR_006560;Note=In HEMB%3B mild. I->T
F9	P00740	130	173	138	138	Natural variant	ID=VAR_073978;Note=In HEMB%3B unknown pathological significance%3B decreased protein abundance%3B decreased function in blood coagulation. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25251685;Dbxref=PMID:25251685
F9	P00740	130	173	139	139	Natural variant	ID=VAR_006561;Note=In HEMB%3B severe. G->D
F9	P00740	130	173	139	139	Natural variant	ID=VAR_006562;Note=In HEMB. G->S
F9	P00740	130	173	155	155	Natural variant	ID=VAR_006563;Note=In HEMB%3B severe. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600455;Dbxref=dbSNP:rs1330705989,PMID:9600455
F9	P00740	130	173	160	160	Natural variant	ID=VAR_006564;Note=In HEMB%3B mild. G->E
F9	P00740	130	173	167	167	Natural variant	ID=VAR_006565;Note=In HEMB%3B mild. Q->H
F9	P00740	130	173	169	169	Natural variant	ID=VAR_017350;Note=In HEMB. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11122099;Dbxref=PMID:11122099
F9	P00740	130	173	170	170	Natural variant	ID=VAR_017351;Note=In HEMB. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12604421;Dbxref=PMID:12604421
F9	P00740	92	130	96	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EDM
F9	P00740	92	130	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMA
F9	P00740	92	130	107	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EDM
F9	P00740	92	130	114	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EDM
F9	P00740	92	130	125	128	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WMA
F9	P00740	130	173	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WPH
F9	P00740	130	173	137	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JB9
F9	P00740	130	173	142	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JB9
F9	P00740	130	173	149	151	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JB9
F9	P00740	130	173	152	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JB9
F9	P00740	130	173	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JB9
F9	P00740	130	173	165	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WPI
F9	P00740	130	173	170	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JB9
H2AFY	O75367	159	196	1	372	Chain	ID=PRO_0000055318;Note=Core histone macro-H2A.1
H2AFY	O75367	159	196	1	372	Chain	ID=PRO_0000055318;Note=Core histone macro-H2A.1
H2AFY	O75367	159	196	184	370	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
H2AFY	O75367	159	196	184	370	Domain	Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
H2AFY	O75367	159	196	118	162	Compositional bias	Note=Lys-rich
H2AFY	O75367	159	196	118	162	Compositional bias	Note=Lys-rich
H2AFY	O75367	159	196	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
H2AFY	O75367	159	196	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
H2AFY	O75367	159	196	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
H2AFY	O75367	159	196	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
H2AFY	O75367	159	196	178	178	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
H2AFY	O75367	159	196	178	178	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
H2AFY	O75367	159	196	167	167	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
H2AFY	O75367	159	196	167	167	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
H2AFY	O75367	159	196	189	189	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
H2AFY	O75367	159	196	189	189	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
H2AFY	O75367	159	196	159	159	Alternative sequence	ID=VSP_038379;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|PubMed:9653160;Dbxref=PMID:12800201,PMID:9653160
H2AFY	O75367	159	196	159	159	Alternative sequence	ID=VSP_038379;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|PubMed:9653160;Dbxref=PMID:12800201,PMID:9653160
H2AFY	O75367	159	196	186	186	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
H2AFY	O75367	159	196	186	186	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
H2AFY	O75367	159	196	174	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IVB
H2AFY	O75367	159	196	174	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IVB
H2AFY	O75367	159	196	185	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZR3
H2AFY	O75367	159	196	185	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZR3
H2AFY	O75367	159	196	196	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZR3
H2AFY	O75367	159	196	196	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZR3
FABP5	Q01469	84	118	2	135	Chain	ID=PRO_0000067377;Note=Fatty acid-binding protein 5
FABP5	Q01469	84	118	82	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZ5
FABP5	Q01469	84	118	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZ5
FABP5	Q01469	84	118	103	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZ5
FABP5	Q01469	84	118	115	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HZ5
H2AFZ	P0C0S5	27	65	2	128	Chain	ID=PRO_0000055297;Note=Histone H2A.Z
H2AFZ	P0C0S5	27	65	30	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CAY
H2AFZ	P0C0S5	27	65	43	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CHL
H2AFZ	P0C0S5	27	65	49	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CAY
ZMPSTE24	O75844	158	209	1	475	Chain	ID=PRO_0000138844;Note=CAAX prenyl protease 1 homolog
ZMPSTE24	O75844	318	353	1	475	Chain	ID=PRO_0000138844;Note=CAAX prenyl protease 1 homolog
ZMPSTE24	O75844	353	401	1	475	Chain	ID=PRO_0000138844;Note=CAAX prenyl protease 1 homolog
ZMPSTE24	O75844	158	209	145	170	Topological domain	Note=Nuclear;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	158	209	171	191	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	158	209	192	195	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	158	209	196	216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	318	353	217	347	Topological domain	Note=Nuclear;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	318	353	348	368	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	353	401	348	368	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	353	401	369	382	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	353	401	383	405	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZMPSTE24	O75844	318	353	336	336	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23539603;Dbxref=PMID:23539603
ZMPSTE24	O75844	318	353	335	335	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23539603;Dbxref=PMID:23539603
ZMPSTE24	O75844	318	353	339	339	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23539603;Dbxref=PMID:23539603
ZMPSTE24	O75844	318	353	340	340	Natural variant	ID=VAR_019308;Note=In MADB. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12913070;Dbxref=dbSNP:rs121908093,PMID:12913070
ZMPSTE24	O75844	158	209	160	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	158	209	196	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	318	353	317	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	318	353	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	318	353	326	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	318	353	344	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	353	401	344	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	353	401	370	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	353	401	375	377	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	353	401	384	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	353	401	394	396	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
ZMPSTE24	O75844	353	401	397	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SYT
FAF2	Q96CS3	21	44	2	445	Chain	ID=PRO_0000244064;Note=FAS-associated factor 2
FAF2	Q96CS3	44	89	2	445	Chain	ID=PRO_0000244064;Note=FAS-associated factor 2
FAF2	Q96CS3	337	385	2	445	Chain	ID=PRO_0000244064;Note=FAS-associated factor 2
FAF2	Q96CS3	21	44	12	48	Domain	Note=UBA
FAF2	Q96CS3	44	89	12	48	Domain	Note=UBA
FAF2	Q96CS3	337	385	357	439	Domain	Note=UBX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00215
FAF2	Q96CS3	337	385	275	350	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAF2	Q96CS3	21	44	11	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAM
FAF2	Q96CS3	21	44	29	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAM
FAF2	Q96CS3	21	44	43	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAM
FAF2	Q96CS3	44	89	43	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAM
PTK2	Q05397	955	982	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	903	955	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	833	854	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	789	833	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	743	789	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	289	325	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	263	289	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	955	982	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	903	955	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	833	854	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	789	833	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	743	789	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	289	325	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	263	289	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
PTK2	Q05397	289	325	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2	Q05397	263	289	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2	Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2	Q05397	289	325	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2	Q05397	263	289	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2	Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2	Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PTK2	Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PTK2	Q05397	955	982	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	903	955	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	833	854	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	789	833	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	743	789	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	955	982	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	903	955	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	833	854	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	789	833	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	743	789	707	1052	Region	Note=Interaction with TGFB1I1
PTK2	Q05397	955	982	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2	Q05397	903	955	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2	Q05397	955	982	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2	Q05397	903	955	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2	Q05397	903	955	863	913	Compositional bias	Note=Pro-rich
PTK2	Q05397	903	955	863	913	Compositional bias	Note=Pro-rich
PTK2	Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2	Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2	Q05397	833	854	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PTK2	Q05397	833	854	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PTK2	Q05397	903	955	910	910	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:20068231,PMID:23186163
PTK2	Q05397	903	955	910	910	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:20068231,PMID:23186163
PTK2	Q05397	903	955	914	914	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PTK2	Q05397	903	955	914	914	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PTK2	Q05397	903	955	925	925	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12387730,ECO:0000269|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
PTK2	Q05397	903	955	925	925	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12387730,ECO:0000269|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
PTK2	Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	289	325	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	263	289	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	289	325	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	263	289	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	955	982	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	903	955	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	833	854	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	789	833	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	743	789	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	955	982	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	903	955	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	833	854	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	789	833	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	743	789	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	955	982	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	903	955	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	833	854	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	789	833	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	743	789	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	955	982	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	903	955	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	833	854	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	789	833	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	743	789	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	789	833	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTK2	Q05397	743	789	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTK2	Q05397	789	833	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTK2	Q05397	743	789	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTK2	Q05397	833	854	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	833	854	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8422239;Dbxref=PMID:8422239
PTK2	Q05397	903	955	903	903	Alternative sequence	ID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTK2	Q05397	903	955	903	903	Alternative sequence	ID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTK2	Q05397	289	325	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
PTK2	Q05397	289	325	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
PTK2	Q05397	289	325	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
PTK2	Q05397	289	325	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
PTK2	Q05397	789	833	793	793	Natural variant	ID=VAR_041684;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
PTK2	Q05397	789	833	793	793	Natural variant	ID=VAR_041684;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
PTK2	Q05397	903	955	928	928	Mutagenesis	Note=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9756887;Dbxref=PMID:9756887
PTK2	Q05397	903	955	928	928	Mutagenesis	Note=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9756887;Dbxref=PMID:9756887
PTK2	Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	743	789	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	743	789	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2	Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	264	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	264	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	268	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	268	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	276	278	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	276	278	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	279	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	263	289	279	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	289	325	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NY0
PTK2	Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
PTK2	Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
PTK2	Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
PTK2	Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
PTK2	Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
PTK2	Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I4E
PTK2	Q05397	903	955	915	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	915	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	923	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	923	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	947	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	947	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	903	955	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
PTK2	Q05397	955	982	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K04
FAM3C	Q92520	4	39	1	24	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM3C	Q92520	110	127	25	227	Chain	ID=PRO_0000008752;Note=Protein FAM3C
FAM3C	Q92520	4	39	25	227	Chain	ID=PRO_0000008752;Note=Protein FAM3C
FAM3C	Q92520	110	127	64	221	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAM3C	Q92520	110	127	111	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LC2
FAM3C	Q92520	110	127	116	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LC2
FAM3C	Q92520	110	127	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LC2
FAM3D	Q96BQ1	4	40	1	25	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM3D	Q96BQ1	4	40	26	224	Chain	ID=PRO_0000008754;Note=Protein FAM3D
FANCM	Q8IYD8	227	253	1	2048	Chain	ID=PRO_0000055176;Note=Fanconi anemia group M protein
FANCM	Q8IYD8	306	350	1	2048	Chain	ID=PRO_0000055176;Note=Fanconi anemia group M protein
FANCM	Q8IYD8	527	596	1	2048	Chain	ID=PRO_0000055176;Note=Fanconi anemia group M protein
FANCM	Q8IYD8	1439	1462	1	2048	Chain	ID=PRO_0000055176;Note=Fanconi anemia group M protein
FANCM	Q8IYD8	227	253	98	266	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
FANCM	Q8IYD8	527	596	452	627	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
FANCM	Q8IYD8	227	253	228	253	Alternative sequence	ID=VSP_054504;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCM	Q8IYD8	1439	1462	670	2048	Alternative sequence	ID=VSP_015990;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FANCM	Q8IYD8	1439	1462	1460	1460	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FANK1	Q8TC84	158	179	1	345	Chain	ID=PRO_0000066990;Note=Fibronectin type 3 and ankyrin repeat domains protein 1
FANK1	Q8TC84	283	309	1	345	Chain	ID=PRO_0000066990;Note=Fibronectin type 3 and ankyrin repeat domains protein 1
FANK1	Q8TC84	309	324	1	345	Chain	ID=PRO_0000066990;Note=Fibronectin type 3 and ankyrin repeat domains protein 1
FANK1	Q8TC84	158	179	143	172	Repeat	Note=ANK 2
FANK1	Q8TC84	158	179	176	205	Repeat	Note=ANK 3
FANK1	Q8TC84	283	309	277	306	Repeat	Note=ANK 6
FBXW2	Q9UKT8	273	302	1	454	Chain	ID=PRO_0000050988;Note=F-box/WD repeat-containing protein 2
FBXW2	Q9UKT8	163	228	1	454	Chain	ID=PRO_0000050988;Note=F-box/WD repeat-containing protein 2
FBXW2	Q9UKT8	163	228	139	175	Repeat	Note=WD 1
FBXW2	Q9UKT8	163	228	179	213	Repeat	Note=WD 2
FBXW2	Q9UKT8	163	228	217	255	Repeat	Note=WD 3
FBXW2	Q9UKT8	273	302	259	306	Repeat	Note=WD 4
FBXW2	Q9UKT8	273	302	298	298	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FBXW2	Q9UKT8	163	228	164	228	Alternative sequence	ID=VSP_012983;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
FBXW4	P57775	279	325	1	412	Chain	ID=PRO_0000050990;Note=F-box/WD repeat-containing protein 4
FBXW4	P57775	257	278	1	412	Chain	ID=PRO_0000050990;Note=F-box/WD repeat-containing protein 4
FBXW4	P57775	87	118	1	412	Chain	ID=PRO_0000050990;Note=F-box/WD repeat-containing protein 4
FBXW4	P57775	257	278	236	277	Repeat	Note=WD 3
FBXW4	P57775	279	325	283	321	Repeat	Note=WD 4
FBXO41	Q8TF61	702	752	1	875	Chain	ID=PRO_0000119940;Note=F-box only protein 41
FBXO41	Q8TF61	641	691	1	875	Chain	ID=PRO_0000119940;Note=F-box only protein 41
FBXO41	Q8TF61	641	691	1	875	Chain	ID=PRO_0000119940;Note=F-box only protein 41
FCN3	O75636	77	88	24	299	Chain	ID=PRO_0000009142;Note=Ficolin-3
FCN3	O75636	77	88	48	80	Domain	Note=Collagen-like
FCN3	O75636	77	88	84	299	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
FCN3	O75636	77	88	77	77	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9694814;Dbxref=PMID:9694814
FCN3	O75636	77	88	86	110	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2J5Z,ECO:0000244|PDB:2J60,ECO:0000269|PubMed:17215869;Dbxref=PMID:17215869
FCN3	O75636	77	88	79	89	Alternative sequence	ID=VSP_001541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FCRL1	Q96LA6	295	334	17	429	Chain	ID=PRO_0000331638;Note=Fc receptor-like protein 1
FCRL1	Q96LA6	17	106	17	429	Chain	ID=PRO_0000331638;Note=Fc receptor-like protein 1
FCRL1	Q96LA6	295	334	17	307	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL1	Q96LA6	17	106	17	307	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL1	Q96LA6	295	334	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL1	Q96LA6	295	334	329	429	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCRL1	Q96LA6	17	106	17	104	Domain	Note=Ig-like C2-type 1
FCRL1	Q96LA6	17	106	38	86	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
FCRL1	Q96LA6	17	106	1	39	Alternative sequence	ID=VSP_033290;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FCRL1	Q96LA6	295	334	239	429	Alternative sequence	ID=VSP_033292;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FCRL1	Q96LA6	295	334	296	334	Alternative sequence	ID=VSP_033293;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EXOC3L4	Q17RC7	567	618	1	722	Chain	ID=PRO_0000274380;Note=Exocyst complex component 3-like protein 4
EXOC2	Q96KP1	707	746	1	924	Chain	ID=PRO_0000118918;Note=Exocyst complex component 2
EXOC2	Q96KP1	617	644	1	924	Chain	ID=PRO_0000118918;Note=Exocyst complex component 2
EXOC2	Q96KP1	397	439	1	924	Chain	ID=PRO_0000118918;Note=Exocyst complex component 2
EXOC2	Q96KP1	141	178	1	924	Chain	ID=PRO_0000118918;Note=Exocyst complex component 2
EXOC2	Q96KP1	39	98	1	924	Chain	ID=PRO_0000118918;Note=Exocyst complex component 2
EXOC2	Q96KP1	39	98	8	93	Domain	Note=IPT/TIG
EXOC2	Q96KP1	397	439	431	431	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EXOC2	Q96KP1	397	439	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EXOC2	Q96KP1	397	439	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EYA4	O95677	69	100	1	639	Chain	ID=PRO_0000218651;Note=Eyes absent homolog 4
EYA4	O95677	69	92	1	639	Chain	ID=PRO_0000218651;Note=Eyes absent homolog 4
EYA4	O95677	69	100	70	123	Alternative sequence	ID=VSP_042160;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EYA4	O95677	69	92	70	123	Alternative sequence	ID=VSP_042160;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EYA4	O95677	69	100	70	92	Alternative sequence	ID=VSP_001495;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EYA4	O95677	69	92	70	92	Alternative sequence	ID=VSP_001495;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EYA4	O95677	69	100	93	93	Alternative sequence	ID=VSP_001496;Note=In isoform 2. M->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAM168A	Q92567	59	101	1	244	Chain	ID=PRO_0000050742;Note=Protein FAM168A
FAM168A	Q92567	59	101	51	59	Alternative sequence	ID=VSP_010095;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334
FAM151B	Q6UXP7	8	50	1	276	Chain	ID=PRO_0000317105;Note=Protein FAM151B
FAM160A2	Q8N612	312	341	1	972	Chain	ID=PRO_0000253859;Note=FTS and Hook-interacting protein
FAM160A2	Q8N612	46	259	1	972	Chain	ID=PRO_0000253859;Note=FTS and Hook-interacting protein
FAM160A2	Q8N612	46	259	1	75	Alternative sequence	ID=VSP_021128;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM160A2	Q8N612	46	259	95	95	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM160A2	Q8N612	46	259	136	136	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM160A2	Q8N612	46	259	186	186	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXOSC7	Q15024	19	53	2	291	Chain	ID=PRO_0000139963;Note=Exosome complex component RRP42
EXOSC7	Q15024	19	53	8	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC7	Q15024	19	53	24	26	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC7	Q15024	19	53	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC7	Q15024	19	53	45	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
FAM120B	Q96EK7	638	672	1	910	Chain	ID=PRO_0000332990;Note=Constitutive coactivator of peroxisome proliferator-activated receptor gamma
FAM120B	Q96EK7	730	761	1	910	Chain	ID=PRO_0000332990;Note=Constitutive coactivator of peroxisome proliferator-activated receptor gamma
FAM120B	Q96EK7	761	830	1	910	Chain	ID=PRO_0000332990;Note=Constitutive coactivator of peroxisome proliferator-activated receptor gamma
FAM120B	Q96EK7	638	672	1	668	Alternative sequence	ID=VSP_055267;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM120B	Q96EK7	761	830	762	764	Alternative sequence	ID=VSP_033415;Note=In isoform 2. PDY->VQT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14585507;Dbxref=PMID:14585507
FAM120B	Q96EK7	761	830	765	910	Alternative sequence	ID=VSP_033416;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14585507;Dbxref=PMID:14585507
FAM149A	A5PLN7	362	418	1	773	Chain	ID=PRO_0000319930;Note=Protein FAM149A
ST13	P50502	227	266	1	369	Chain	ID=PRO_0000190811;Note=Hsc70-interacting protein
FAM173B	Q6P4H8	148	165	1	233	Chain	ID=PRO_0000321536;Note=Protein N-lysine methyltransferase FAM173B
FAM173B	Q6P4H8	148	165	149	165	Alternative sequence	ID=VSP_044724;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM177A1	Q8N128	32	90	1	213	Chain	ID=PRO_0000089885;Note=Protein FAM177A1
FAM177A1	Q8N128	32	90	1	213	Chain	ID=PRO_0000089885;Note=Protein FAM177A1
FAM177A1	Q8N128	32	90	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
FAM177A1	Q8N128	32	90	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
FAM177A1	Q8N128	32	90	71	71	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
FAM177A1	Q8N128	32	90	71	71	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
FAM177A1	Q8N128	32	90	47	47	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM177A1	Q8N128	32	90	47	47	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM177A1	Q8N128	32	90	56	56	Sequence conflict	Note=R->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM177A1	Q8N128	32	90	56	56	Sequence conflict	Note=R->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM177A1	Q8N128	32	90	62	62	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM177A1	Q8N128	32	90	62	62	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
F7	P08709	21	43	21	60	Propeptide	ID=PRO_0000027729;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3264725;Dbxref=PMID:3264725
F7	P08709	143	190	61	212	Chain	ID=PRO_0000027730;Note=Factor VII light chain
F7	P08709	143	190	147	188	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
F7	P08709	143	190	151	162	Disulfide bond	.
F7	P08709	143	190	158	172	Disulfide bond	.
F7	P08709	143	190	174	187	Disulfide bond	.
F7	P08709	21	43	22	43	Alternative sequence	ID=VSP_005387;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3486420;Dbxref=PMID:15489334,PMID:3486420
F7	P08709	143	190	151	151	Natural variant	ID=VAR_014410;Note=In FA7D. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11129332;Dbxref=PMID:11129332
F7	P08709	143	190	154	154	Natural variant	ID=VAR_015137;Note=In FA7D. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10862079,ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs146795869,PMID:10862079,PMID:18976247
F7	P08709	143	190	156	156	Natural variant	ID=VAR_065378;Note=In FA7D. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs563972504,PMID:18976247
F7	P08709	143	190	157	157	Natural variant	ID=VAR_006501;Note=In FA7D. G->C
F7	P08709	143	190	157	157	Natural variant	ID=VAR_006500;Note=In FA7D. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10862079,ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs763458490,PMID:10862079,PMID:18976247
F7	P08709	143	190	157	157	Natural variant	ID=VAR_014411;Note=In FA7D. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11129332;Dbxref=dbSNP:rs771335282,PMID:11129332
F7	P08709	143	190	160	160	Natural variant	ID=VAR_006502;Note=In FA7D. Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10862079,ECO:0000269|PubMed:11129332,ECO:0000269|PubMed:18976247,ECO:0000269|PubMed:8242057;Dbxref=dbSNP:rs200016360,PMID:10862079,PMID:11129332,PMID:18976247,PMID:8242057
F7	P08709	143	190	171	171	Natural variant	ID=VAR_065379;Note=In FA7D. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs143855920,PMID:18976247
F7	P08709	143	190	177	177	Natural variant	ID=VAR_065380;Note=In FA7D. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19751712;Dbxref=PMID:19751712
F7	P08709	143	190	181	181	Natural variant	ID=VAR_065381;Note=In FA7D. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18976247;Dbxref=PMID:18976247
F7	P08709	143	190	183	183	Natural variant	ID=VAR_065382;Note=In FA7D. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs1258691292,PMID:18976247
F7	P08709	143	190	186	186	Natural variant	ID=VAR_065383;Note=In FA7D. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs764971156,PMID:18976247
F7	P08709	143	190	189	189	Natural variant	ID=VAR_065384;Note=In FA7D. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18976247;Dbxref=dbSNP:rs1479693459,PMID:18976247
F7	P08709	143	190	145	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C4F
F7	P08709	143	190	148	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QFK
F7	P08709	143	190	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YLQ
F7	P08709	143	190	154	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PAG
F7	P08709	143	190	159	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PAG
F7	P08709	143	190	166	168	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PAG
F7	P08709	143	190	169	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PAG
F7	P08709	143	190	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PAG
F7	P08709	143	190	187	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PAG
FAM83G	A6ND36	174	230	2	823	Chain	ID=PRO_0000330817;Note=Protein FAM83G
FAM83G	A6ND36	174	230	2	823	Chain	ID=PRO_0000330817;Note=Protein FAM83G
FAM83G	A6ND36	174	230	1	248	Alternative sequence	ID=VSP_033120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM83G	A6ND36	174	230	1	248	Alternative sequence	ID=VSP_033120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSMAF	Q92636	484	528	1	917	Chain	ID=PRO_0000050975;Note=Protein FAN
NSMAF	Q92636	289	348	1	917	Chain	ID=PRO_0000050975;Note=Protein FAN
NSMAF	Q92636	111	128	1	917	Chain	ID=PRO_0000050975;Note=Protein FAN
NSMAF	Q92636	484	528	290	575	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
NSMAF	Q92636	289	348	290	575	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
FARP1	Q9Y4F1	57	92	1	1045	Chain	ID=PRO_0000232753;Note=FERM%2C ARHGEF and pleckstrin domain-containing protein 1
FARP1	Q9Y4F1	534	564	1	1045	Chain	ID=PRO_0000232753;Note=FERM%2C ARHGEF and pleckstrin domain-containing protein 1
FARP1	Q9Y4F1	758	781	1	1045	Chain	ID=PRO_0000232753;Note=FERM%2C ARHGEF and pleckstrin domain-containing protein 1
FARP1	Q9Y4F1	781	811	1	1045	Chain	ID=PRO_0000232753;Note=FERM%2C ARHGEF and pleckstrin domain-containing protein 1
FARP1	Q9Y4F1	57	92	40	320	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FARP1	Q9Y4F1	534	564	540	730	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
FARP1	Q9Y4F1	758	781	759	856	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FARP1	Q9Y4F1	781	811	759	856	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FARP1	Q9Y4F1	57	92	58	129	Alternative sequence	ID=VSP_040989;Note=In isoform 3. QRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQE->MVSSSSFLKATGSSWTGWVLRCSMKPKHHSHLIEKFGEDRILTHLTGSISYTNWAGSRSLAVTVTEELLNLF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FARP1	Q9Y4F1	534	564	130	1045	Alternative sequence	ID=VSP_040990;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FARP1	Q9Y4F1	758	781	130	1045	Alternative sequence	ID=VSP_040990;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FARP1	Q9Y4F1	781	811	130	1045	Alternative sequence	ID=VSP_040990;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FARP1	Q9Y4F1	758	781	758	758	Alternative sequence	ID=VSP_017976;Note=In isoform 2. R->RPGSFSLMRTPHLGQARRIPCAPERRPLLLVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCC	Q00597	443	511	1	558	Chain	ID=PRO_0000087184;Note=Fanconi anemia group C protein
FANCC	Q00597	174	228	1	558	Chain	ID=PRO_0000087184;Note=Fanconi anemia group C protein
FANCC	Q00597	443	511	1	558	Chain	ID=PRO_0000087184;Note=Fanconi anemia group C protein
FANCC	Q00597	174	228	1	558	Chain	ID=PRO_0000087184;Note=Fanconi anemia group C protein
FANCC	Q00597	174	228	190	190	Natural variant	ID=VAR_005227;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8844212;Dbxref=dbSNP:rs1800364,PMID:8844212
FANCC	Q00597	174	228	190	190	Natural variant	ID=VAR_005227;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8844212;Dbxref=dbSNP:rs1800364,PMID:8844212
FANCC	Q00597	174	228	195	195	Natural variant	ID=VAR_005228;Note=In FANCC. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8128956;Dbxref=dbSNP:rs1800365,PMID:8128956
FANCC	Q00597	174	228	195	195	Natural variant	ID=VAR_005228;Note=In FANCC. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8128956;Dbxref=dbSNP:rs1800365,PMID:8128956
FANCC	Q00597	443	511	449	449	Natural variant	ID=VAR_005230;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8844212,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1800367,PMID:8844212
FANCC	Q00597	443	511	449	449	Natural variant	ID=VAR_005230;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8844212,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1800367,PMID:8844212
FANCC	Q00597	443	511	465	465	Natural variant	ID=VAR_005231;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8844212;Dbxref=dbSNP:rs1800368,PMID:8844212
FANCC	Q00597	443	511	465	465	Natural variant	ID=VAR_005231;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8844212;Dbxref=dbSNP:rs1800368,PMID:8844212
FANCC	Q00597	443	511	496	496	Natural variant	ID=VAR_005232;Note=In FANCC. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8844212;Dbxref=dbSNP:rs121917785,PMID:8844212
FANCC	Q00597	443	511	496	496	Natural variant	ID=VAR_005232;Note=In FANCC. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8844212;Dbxref=dbSNP:rs121917785,PMID:8844212
FAXC	Q5TGI0	274	313	1	409	Chain	ID=PRO_0000089556;Note=Failed axon connections homolog
FAXC	Q5TGI0	274	313	1	280	Alternative sequence	ID=VSP_056994;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FBN2	P35556	2531	2570	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	2252	2293	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	1572	1626	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	1531	1572	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	359	410	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	112	145	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	2531	2570	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	2252	2293	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	1572	1626	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	1531	1572	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	359	410	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	112	145	78	2779	Chain	ID=PRO_0000007584;Note=Fibrillin-2;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBN2	P35556	112	145	111	142	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	111	142	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	145	176	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	145	176	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	359	410	318	359	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	359	410	318	359	Domain	Note=EGF-like 5%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	359	410	364	417	Domain	Note=TB 2
FBN2	P35556	359	410	364	417	Domain	Note=TB 2
FBN2	P35556	1531	1572	1491	1531	Domain	Note=EGF-like 25%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1491	1531	Domain	Note=EGF-like 25%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1572	1626	1532	1572	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1532	1572	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1572	1626	1532	1572	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1532	1572	Domain	Note=EGF-like 26%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1572	1626	1577	1633	Domain	Note=TB 6
FBN2	P35556	1572	1626	1577	1633	Domain	Note=TB 6
FBN2	P35556	2252	2293	2213	2252	Domain	Note=EGF-like 37%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2213	2252	Domain	Note=EGF-like 37%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2253	2293	Domain	Note=EGF-like 38%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2253	2293	Domain	Note=EGF-like 38%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2491	2531	Domain	Note=EGF-like 42%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2491	2531	Domain	Note=EGF-like 42%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2532	2570	Domain	Note=EGF-like 43%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2532	2570	Domain	Note=EGF-like 43%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	359	410	149	359	Region	Note=Interaction with MFAP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26601954;Dbxref=PMID:26601954
FBN2	P35556	359	410	149	359	Region	Note=Interaction with MFAP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26601954;Dbxref=PMID:26601954
FBN2	P35556	1572	1626	1625	1625	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBN2	P35556	1572	1626	1625	1625	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBN2	P35556	112	145	115	124	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	115	124	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	119	130	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	119	130	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	132	141	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	132	141	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1536	1547	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1536	1547	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1542	1556	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1542	1556	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1558	1571	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	1531	1572	1558	1571	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2257	2268	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2257	2268	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2264	2277	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2264	2277	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2279	2292	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2252	2293	2279	2292	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2536	2547	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2536	2547	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2543	2556	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2543	2556	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2558	2569	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	2531	2570	2558	2569	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBN2	P35556	112	145	113	145	Alternative sequence	ID=VSP_037369;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	112	145	113	145	Alternative sequence	ID=VSP_037369;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	2531	2570	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	2252	2293	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	1572	1626	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	1531	1572	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	2531	2570	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	2252	2293	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	1572	1626	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	1531	1572	1507	2912	Alternative sequence	ID=VSP_037371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1852206;Dbxref=PMID:14702039,PMID:1852206
FBN2	P35556	359	410	391	391	Natural variant	ID=VAR_015851;Note=In DA9. E->K;Dbxref=dbSNP:rs137852826
FBN2	P35556	359	410	391	391	Natural variant	ID=VAR_015851;Note=In DA9. E->K;Dbxref=dbSNP:rs137852826
FBN2	P35556	2252	2293	2266	2266	Natural variant	ID=VAR_054989;Note=F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8120105,ECO:0000269|PubMed:9714438;Dbxref=PMID:8120105,PMID:9714438
FBN2	P35556	2252	2293	2266	2266	Natural variant	ID=VAR_054989;Note=F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8120105,ECO:0000269|PubMed:9714438;Dbxref=PMID:8120105,PMID:9714438
FBN2	P35556	2252	2293	2278	2278	Natural variant	ID=VAR_055415;Note=T->M;Dbxref=dbSNP:rs2307109
FBN2	P35556	2252	2293	2278	2278	Natural variant	ID=VAR_055415;Note=T->M;Dbxref=dbSNP:rs2307109
FNBP1L	Q5T0N5	47	64	1	605	Chain	ID=PRO_0000261434;Note=Formin-binding protein 1-like
FNBP1L	Q5T0N5	330	383	1	605	Chain	ID=PRO_0000261434;Note=Formin-binding protein 1-like
FNBP1L	Q5T0N5	550	603	1	605	Chain	ID=PRO_0000261434;Note=Formin-binding protein 1-like
FNBP1L	Q5T0N5	47	64	1	263	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
FNBP1L	Q5T0N5	550	603	538	599	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FNBP1L	Q5T0N5	330	383	245	535	Region	Note=Interaction with CDC42
FNBP1L	Q5T0N5	550	603	522	605	Region	Note=Interaction with DNM1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16326391;Dbxref=PMID:16326391
FNBP1L	Q5T0N5	550	603	541	605	Region	Note=Interaction with DAAM1%2C DIAPH1 and DIAPH2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16630611;Dbxref=PMID:16630611
FNBP1L	Q5T0N5	550	603	541	597	Region	Note=Interaction with DNM2 and WASL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16418535;Dbxref=PMID:16418535
FNBP1L	Q5T0N5	330	383	331	388	Alternative sequence	ID=VSP_021709;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15260990,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15260990,PMID:15489334
FNBP1L	Q5T0N5	550	603	576	576	Mutagenesis	Note=Impairs interaction with WASL and reduces CDC42-induced actin assembly. W->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15260990;Dbxref=PMID:15260990
FBLN5	Q9UBX5	167	206	24	448	Chain	ID=PRO_0000007577;Note=Fibulin-5
FBLN5	Q9UBX5	126	167	24	448	Chain	ID=PRO_0000007577;Note=Fibulin-5
FBLN5	Q9UBX5	41	126	24	448	Chain	ID=PRO_0000007577;Note=Fibulin-5
FBLN5	Q9UBX5	41	126	42	82	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	167	206	127	167	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	126	167	127	167	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	167	206	168	206	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	41	126	54	56	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
FBLN5	Q9UBX5	41	126	46	59	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	41	126	53	68	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	126	167	131	144	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	126	167	138	153	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	126	167	155	166	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	167	206	172	181	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	167	206	177	190	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	167	206	192	205	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FBLN5	Q9UBX5	41	126	48	48	Natural variant	ID=VAR_076289;Note=In HNARMD. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21576112;Dbxref=dbSNP:rs141200859,PMID:21576112
FBLN5	Q9UBX5	41	126	60	60	Natural variant	ID=VAR_019814;Note=In ARMD3%3B no effect on secretion%3B no effect on homodimerization. V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15269314,ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835;Dbxref=dbSNP:rs121434299,PMID:15269314,PMID:16652333,PMID:20007835
FBLN5	Q9UBX5	41	126	71	71	Natural variant	ID=VAR_019815;Note=In ARMD3%3B no effect on secretion%3B no effect on homodimerization. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15269314,ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835;Dbxref=dbSNP:rs121434300,PMID:15269314,PMID:16652333,PMID:20007835
FBLN5	Q9UBX5	41	126	87	87	Natural variant	ID=VAR_019816;Note=In ARMD3%3B no effect on secretion%3B slightly increases homodimerization in absence of Ca(2+). P->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15269314,ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835;Dbxref=dbSNP:rs121434301,PMID:15269314,PMID:16652333,PMID:20007835
FBLN5	Q9UBX5	41	126	90	90	Natural variant	ID=VAR_076290;Note=In HNARMD. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21576112;Dbxref=dbSNP:rs144288844,PMID:21576112
FBLN5	Q9UBX5	41	126	124	124	Natural variant	ID=VAR_072389;Note=In ARMD3%3B almost abolishes secretion%3B no effect on homodimerization. Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835;Dbxref=PMID:16652333,PMID:20007835
FBLN5	Q9UBX5	126	167	126	126	Natural variant	ID=VAR_072390;Note=Polymorphism%3B no effect on secretion%3B slightly increases homodimerization in absence of Ca(2+). V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835,ECO:0000269|PubMed:21576112;Dbxref=dbSNP:rs61734479,PMID:16652333,PMID:20007835,PMID:21576112
FBLN5	Q9UBX5	41	126	126	126	Natural variant	ID=VAR_072390;Note=Polymorphism%3B no effect on secretion%3B slightly increases homodimerization in absence of Ca(2+). V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835,ECO:0000269|PubMed:21576112;Dbxref=dbSNP:rs61734479,PMID:16652333,PMID:20007835,PMID:21576112
FBLN5	Q9UBX5	167	206	169	169	Natural variant	ID=VAR_019817;Note=In ARMD3%3B decreases secretion%3B slightly increases homodimerization in absence of Ca(2+)%3B no effect on protein folding. I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15269314,ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835,ECO:0000269|PubMed:20599547;Dbxref=dbSNP:rs28939072,PMID:15269314,PMID:16652333,PMID:20007835,PMID:20599547
FBLN5	Q9UBX5	167	206	202	202	Natural variant	ID=VAR_072391;Note=Polymorphism%3B slightly increases homodimerization in absence of Ca(2+)%3B no effect on protein folding%3B no effect on secretion. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16652333,ECO:0000269|PubMed:20007835,ECO:0000269|PubMed:20599547;Dbxref=dbSNP:rs80338765,PMID:16652333,PMID:20007835,PMID:20599547
FBLN5	Q9UBX5	41	126	69	70	Sequence conflict	Note=IP->HS;Ontology_term=ECO:0000305;evidence=ECO:0000305
FBLN5	Q9UBX5	126	167	147	148	Sequence conflict	Note=TE->MK;Ontology_term=ECO:0000305;evidence=ECO:0000305
FCER1G	P30273	47	59	19	86	Chain	ID=PRO_0000016501;Note=High affinity immunoglobulin epsilon receptor subunit gamma
FCER1G	P30273	47	59	45	86	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FCER1G	P30273	47	59	54	82	Domain	Note=ITAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00379
FBXO42	Q6P3S6	307	346	1	717	Chain	ID=PRO_0000119942;Note=F-box only protein 42
FBXO42	Q6P3S6	83	122	1	717	Chain	ID=PRO_0000119942;Note=F-box only protein 42
FBXO42	Q6P3S6	83	122	44	93	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXO42	Q6P3S6	307	346	295	342	Repeat	Note=Kelch 4
FBXO24	O75426	13	46	1	580	Chain	ID=PRO_0000119909;Note=F-box only protein 24
FBXO24	O75426	402	459	1	580	Chain	ID=PRO_0000119909;Note=F-box only protein 24
FBXO24	O75426	13	46	36	82	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXO24	O75426	402	459	376	425	Repeat	Note=RCC1
FBXO24	O75426	13	46	1	13	Alternative sequence	ID=VSP_043458;Note=In isoform 4. MGEKAVPLLRRRR->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FBXO24	O75426	402	459	333	580	Alternative sequence	ID=VSP_011353;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531035;Dbxref=PMID:10531035
APPL1	Q9UKG1	51	71	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	71	95	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	124	138	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	158	207	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	235	287	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	288	350	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	365	384	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	416	476	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	614	631	1	709	Chain	ID=PRO_0000079985;Note=DCC-interacting protein 13-alpha
APPL1	Q9UKG1	235	287	277	375	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APPL1	Q9UKG1	288	350	277	375	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APPL1	Q9UKG1	365	384	277	375	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APPL1	Q9UKG1	614	631	496	656	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APPL1	Q9UKG1	51	71	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	71	95	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	124	138	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	158	207	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	235	287	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	288	350	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	365	384	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	416	476	1	428	Region	Note=Required for RAB5A binding
APPL1	Q9UKG1	235	287	215	259	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
APPL1	Q9UKG1	614	631	621	673	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
APPL1	Q9UKG1	71	95	94	94	Natural variant	ID=VAR_075857;Note=In MODY14%3B no effect on protein abundance%3B loss of function in insulin receptor signaling pathway. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26073777;Dbxref=dbSNP:rs796065047,PMID:26073777
APPL1	Q9UKG1	51	71	16	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q12
APPL1	Q9UKG1	51	71	67	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q12
APPL1	Q9UKG1	71	95	81	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q12
APPL1	Q9UKG1	124	138	122	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q12
APPL1	Q9UKG1	158	207	157	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q12
APPL1	Q9UKG1	235	287	220	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q12
APPL1	Q9UKG1	235	287	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	235	287	262	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	235	287	268	270	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	235	287	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	288	350	298	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	288	350	308	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	288	350	320	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	288	350	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	288	350	339	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	288	350	348	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ELB
APPL1	Q9UKG1	365	384	360	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q13
APPL1	Q9UKG1	614	631	612	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJ8
DPM1	O60762	165	187	2	260	Chain	ID=PRO_0000059170;Note=Dolichol-phosphate mannosyltransferase subunit 1
DPM1	O60762	133	164	2	260	Chain	ID=PRO_0000059170;Note=Dolichol-phosphate mannosyltransferase subunit 1
DPM1	O60762	133	164	152	152	Natural variant	ID=VAR_070592;Note=In CDG1E%3B abolishes interaction with DPM3. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23856421;Dbxref=dbSNP:rs587777116,PMID:23856421
DPM1	O60762	133	164	135	135	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPM1	O60762	133	164	143	143	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPM1	O60762	133	164	154	154	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPM1	O60762	165	187	177	177	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
DRD2	P14416	241	270	1	443	Chain	ID=PRO_0000069387;Note=D(2) dopamine receptor
DRD2	P14416	241	270	1	443	Chain	ID=PRO_0000069387;Note=D(2) dopamine receptor
DRD2	P14416	241	270	214	373	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
DRD2	P14416	241	270	214	373	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
DRD2	P14416	241	270	211	373	Region	Note=Interaction with PPP1R9B;Ontology_term=ECO:0000250;evidence=ECO:0000250
DRD2	P14416	241	270	211	373	Region	Note=Interaction with PPP1R9B;Ontology_term=ECO:0000250;evidence=ECO:0000250
DRD2	P14416	241	270	242	270	Alternative sequence	ID=VSP_001870;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2531656;Dbxref=PMID:2531656
DRD2	P14416	241	270	242	270	Alternative sequence	ID=VSP_001870;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2531656;Dbxref=PMID:2531656
DRD2	P14416	241	270	270	270	Alternative sequence	ID=VSP_026455;Note=In isoform 3. V->VVQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10719223;Dbxref=PMID:10719223
DRD2	P14416	241	270	270	270	Alternative sequence	ID=VSP_026455;Note=In isoform 3. V->VVQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10719223;Dbxref=PMID:10719223
DUS1L	Q6P1R4	115	132	1	473	Chain	ID=PRO_0000247226;Note=tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
DUS1L	Q6P1R4	115	132	1	473	Chain	ID=PRO_0000247226;Note=tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
EPB41L4B	Q9H329	767	806	1	900	Chain	ID=PRO_0000219404;Note=Band 4.1-like protein 4B
EPB41L4B	Q9H329	178	192	1	900	Chain	ID=PRO_0000219404;Note=Band 4.1-like protein 4B
EPB41L4B	Q9H329	178	192	85	369	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L4B	Q9H329	767	806	519	900	Alternative sequence	ID=VSP_007203;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10603000,ECO:0000303|PubMed:10783258;Dbxref=PMID:10603000,PMID:10783258
SLC1A1	P43005	77	108	1	524	Chain	ID=PRO_0000202065;Note=Excitatory amino acid transporter 3
SLC1A1	P43005	256	291	1	524	Chain	ID=PRO_0000202065;Note=Excitatory amino acid transporter 3
SLC1A1	P43005	398	442	1	524	Chain	ID=PRO_0000202065;Note=Excitatory amino acid transporter 3
SLC1A1	P43005	77	108	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A1	P43005	77	108	83	93	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	77	108	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A1	P43005	256	291	239	266	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A1	P43005	256	291	267	286	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	256	291	287	308	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A1	P43005	398	442	394	427	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A1	P43005	398	442	428	440	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	398	442	441	462	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A1	P43005	398	442	411	415	Region	Note=Aspartate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43003
SLC1A1	P43005	77	108	92	92	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	77	108	94	94	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	77	108	94	94	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	77	108	96	96	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	256	291	260	260	Sequence conflict	Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A1	P43005	256	291	280	280	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNM2	P50570	78	128	1	870	Chain	ID=PRO_0000206570;Note=Dynamin-2
DNM2	P50570	445	474	1	870	Chain	ID=PRO_0000206570;Note=Dynamin-2
DNM2	P50570	519	557	1	870	Chain	ID=PRO_0000206570;Note=Dynamin-2
DNM2	P50570	631	686	1	870	Chain	ID=PRO_0000206570;Note=Dynamin-2
DNM2	P50570	78	128	28	294	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
DNM2	P50570	519	557	519	625	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
DNM2	P50570	631	686	653	744	Domain	Note=GED;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00720
DNM2	P50570	519	557	516	519	Alternative sequence	ID=VSP_001325;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7590285;Dbxref=PMID:14702039,PMID:15489334,PMID:7590285
DNM2	P50570	445	474	465	465	Natural variant	ID=VAR_031965;Note=In CNM1%3B reduced association with the centrosome%3B COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16227997,ECO:0000269|PubMed:19623537,ECO:0000269|PubMed:20227276;Dbxref=dbSNP:rs121909091,PMID:16227997,PMID:19623537,PMID:20227276
DNM2	P50570	519	557	522	522	Natural variant	ID=VAR_068366;Note=In CNM1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22396310;Dbxref=PMID:22396310
DNM2	P50570	519	557	522	522	Natural variant	ID=VAR_068367;Note=In CNM1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20227276;Dbxref=dbSNP:rs587783595,PMID:20227276
DNM2	P50570	519	557	523	523	Natural variant	ID=VAR_068368;Note=In CNM1. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22396310;Dbxref=dbSNP:rs587783596,PMID:22396310
DNM2	P50570	519	557	537	537	Natural variant	ID=VAR_062574;Note=In CMT2M. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17636067;Dbxref=dbSNP:rs121909093,PMID:17636067
DNM2	P50570	519	557	555	557	Natural variant	ID=VAR_031966;Note=In CMTDIB%3B may affect binding to vesicles and membranes in favor of binding to microtubules%3B may affect receptor-mediated endocytosis. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731758;Dbxref=PMID:15731758
DNM2	P50570	631	686	650	650	Natural variant	ID=VAR_062576;Note=In CNM1%3B COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19623537;Dbxref=PMID:19623537
DNM2	P50570	519	557	522	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS1
DNM2	P50570	519	557	533	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS1
DNM2	P50570	519	557	540	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS1
DNM2	P50570	519	557	550	555	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS1
SLC1A7	O00341	409	453	1	560	Chain	ID=PRO_0000202073;Note=Excitatory amino acid transporter 5
SLC1A7	O00341	409	453	414	434	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A7	O00341	409	453	159	560	Alternative sequence	ID=VSP_056561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC1A7	O00341	409	453	412	412	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A7	O00341	409	453	449	449	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EDIL3	O43854	118	156	24	480	Chain	ID=PRO_0000007522;Note=EGF-like repeat and discoidin I-like domain-containing protein 3
EDIL3	O43854	75	118	24	480	Chain	ID=PRO_0000007522;Note=EGF-like repeat and discoidin I-like domain-containing protein 3
EDIL3	O43854	65	75	24	480	Chain	ID=PRO_0000007522;Note=EGF-like repeat and discoidin I-like domain-containing protein 3
EDIL3	O43854	75	118	74	117	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EDIL3	O43854	65	75	74	117	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EDIL3	O43854	118	156	119	155	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EDIL3	O43854	75	118	96	98	Motif	Note=Cell attachment site
EDIL3	O43854	118	156	119	119	Metal binding	Note=Calcium
EDIL3	O43854	118	156	120	120	Metal binding	Note=Calcium%3B via carbonyl oxygen
EDIL3	O43854	118	156	122	122	Metal binding	Note=Calcium
EDIL3	O43854	118	156	136	136	Metal binding	Note=Calcium
EDIL3	O43854	118	156	137	137	Metal binding	Note=Calcium%3B via carbonyl oxygen
EDIL3	O43854	65	75	73	73	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	75	118	88	88	Glycosylation	Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	118	156	140	140	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	75	118	78	89	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	75	118	83	105	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	75	118	107	116	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	118	156	123	134	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	118	156	128	143	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	118	156	145	154	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22601780;Dbxref=PMID:22601780
EDIL3	O43854	65	75	66	66	Alternative sequence	ID=VSP_050006;Note=In isoform 2. A->G;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9420328;Dbxref=PMID:15489334,PMID:9420328
EDIL3	O43854	75	118	67	76	Alternative sequence	ID=VSP_050007;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9420328;Dbxref=PMID:15489334,PMID:9420328
EDIL3	O43854	65	75	67	76	Alternative sequence	ID=VSP_050007;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9420328;Dbxref=PMID:15489334,PMID:9420328
EDIL3	O43854	65	75	66	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EDIL3	O43854	75	118	88	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EDIL3	O43854	75	118	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EDIL3	O43854	75	118	111	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EDIL3	O43854	118	156	122	125	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EDIL3	O43854	118	156	133	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EDIL3	O43854	118	156	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D90
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GFM1	Q96RP9	191	229	37	751	Chain	ID=PRO_0000007440;Note=Elongation factor G%2C mitochondrial
GFM1	Q96RP9	361	407	37	751	Chain	ID=PRO_0000007440;Note=Elongation factor G%2C mitochondrial
GFM1	Q96RP9	690	708	37	751	Chain	ID=PRO_0000007440;Note=Elongation factor G%2C mitochondrial
GFM1	Q96RP9	191	229	44	321	Domain	Note=tr-type G
GFM1	Q96RP9	191	229	215	215	Natural variant	ID=VAR_028303;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2303909,PMID:14702039
GFM1	Q96RP9	361	407	373	373	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
LIG3	P49916	182	230	43	1009	Chain	ID=PRO_0000059574;Note=DNA ligase 3
LIG3	P49916	230	296	43	1009	Chain	ID=PRO_0000059574;Note=DNA ligase 3
LIG3	P49916	752	777	43	1009	Chain	ID=PRO_0000059574;Note=DNA ligase 3
LIG3	P49916	777	826	43	1009	Chain	ID=PRO_0000059574;Note=DNA ligase 3
LIG3	P49916	182	230	93	185	Zinc finger	Note=PARP-type;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00264,ECO:0000269|PubMed:15288782;Dbxref=PMID:15288782
LIG3	P49916	230	296	277	280	Region	Note=Interaction with DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20518483;Dbxref=PMID:20518483
LIG3	P49916	182	230	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:20068231,PMID:21406692,PMID:23186163
LIG3	P49916	182	230	216	216	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LIG3	P49916	182	230	227	227	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
LIG3	P49916	230	296	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LIG3	P49916	182	230	224	224	Natural variant	ID=VAR_020196;Note=R->W;Dbxref=dbSNP:rs3744356
LIG3	P49916	752	777	768	768	Natural variant	ID=VAR_072387;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20843780;Dbxref=dbSNP:rs200981995,PMID:20843780
LIG3	P49916	182	230	171	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UW0
LIG3	P49916	182	230	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UW0
LIG3	P49916	230	296	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	230	296	263	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	230	296	279	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	777	826	780	787	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	777	826	789	791	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	777	826	795	797	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	777	826	800	804	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	777	826	816	819	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
LIG3	P49916	777	826	822	830	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L2P
DSC2	Q02487	629	708	136	901	Chain	ID=PRO_0000003870;Note=Desmocollin-2
DSC2	Q02487	554	629	136	901	Chain	ID=PRO_0000003870;Note=Desmocollin-2
DSC2	Q02487	314	359	136	901	Chain	ID=PRO_0000003870;Note=Desmocollin-2
DSC2	Q02487	629	708	136	694	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC2	Q02487	554	629	136	694	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC2	Q02487	314	359	136	694	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC2	Q02487	629	708	695	715	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC2	Q02487	314	359	244	355	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC2	Q02487	314	359	356	471	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC2	Q02487	554	629	472	579	Domain	Note=Cadherin 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC2	Q02487	629	708	580	694	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC2	Q02487	554	629	580	694	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC2	Q02487	629	708	629	629	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16740002;Dbxref=PMID:16740002
DSC2	Q02487	554	629	629	629	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16740002;Dbxref=PMID:16740002
DSC2	Q02487	314	359	340	340	Natural variant	ID=VAR_065690;Note=In ARVD11. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19863551;Dbxref=dbSNP:rs368299411,PMID:19863551
DSC2	Q02487	314	359	358	358	Natural variant	ID=VAR_062391;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18678517;Dbxref=dbSNP:rs139399951,PMID:18678517
DSC2	Q02487	554	629	596	596	Natural variant	ID=VAR_065691;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs148185335,PMID:20031617
DSC2	Q02487	629	708	638	638	Natural variant	ID=VAR_065692;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs147742157,PMID:20031617
DSC2	Q02487	314	359	313	315	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	314	359	318	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	314	359	328	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	314	359	336	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	314	359	354	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	558	568	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	586	588	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	590	595	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	602	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	609	611	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	617	622	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	629	708	624	636	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	554	629	624	636	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	629	708	643	645	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	629	708	648	653	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	629	708	659	664	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC2	Q02487	629	708	672	675	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERP
DSC3	Q14574	118	158	28	135	Propeptide	ID=PRO_0000003875;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC3	Q14574	158	210	136	896	Chain	ID=PRO_0000003876;Note=Desmocollin-3
DSC3	Q14574	118	158	136	896	Chain	ID=PRO_0000003876;Note=Desmocollin-3
DSC3	Q14574	158	210	136	690	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC3	Q14574	118	158	136	690	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC3	Q14574	158	210	136	243	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC3	Q14574	118	158	136	243	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC3	Q14574	158	210	166	166	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC3	Q14574	158	210	180	180	Natural variant	ID=VAR_048518;Note=K->Q;Dbxref=dbSNP:rs35296997
DSC3	Q14574	158	210	199	199	Natural variant	ID=VAR_048519;Note=R->W;Dbxref=dbSNP:rs276921
DSCAM	O60469	1570	1629	18	2012	Chain	ID=PRO_0000014747;Note=Down syndrome cell adhesion molecule
DSCAM	O60469	311	403	18	2012	Chain	ID=PRO_0000014747;Note=Down syndrome cell adhesion molecule
DSCAM	O60469	1570	1629	18	1595	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSCAM	O60469	311	403	18	1595	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSCAM	O60469	1570	1629	1596	1616	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSCAM	O60469	1570	1629	1617	2012	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSCAM	O60469	311	403	313	401	Domain	Note=Ig-like C2-type 4
DSCAM	O60469	1570	1629	1474	1575	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
DSCAM	O60469	311	403	335	385	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
DSCAM	O60469	1570	1629	1562	1571	Alternative sequence	ID=VSP_002502;Note=In isoform Short. NFATLNYDGS->KEAARCKEFS;Ontology_term=ECO:0000305;evidence=ECO:0000305
DSCAM	O60469	1570	1629	1572	2012	Alternative sequence	ID=VSP_002503;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DTWD1	Q8N5C7	88	136	2	304	Chain	ID=PRO_0000308212;Note=DTW domain-containing protein 1
DTWD1	Q8N5C7	88	136	2	304	Chain	ID=PRO_0000308212;Note=DTW domain-containing protein 1
DTWD1	Q8N5C7	88	136	2	304	Chain	ID=PRO_0000308212;Note=DTW domain-containing protein 1
DTWD1	Q8N5C7	88	136	1	88	Alternative sequence	ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DTWD1	Q8N5C7	88	136	1	88	Alternative sequence	ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DTWD1	Q8N5C7	88	136	1	88	Alternative sequence	ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DTWD1	Q8N5C7	88	136	89	304	Alternative sequence	ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLYHLGQSMVSSASKITCIG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DTWD1	Q8N5C7	88	136	89	304	Alternative sequence	ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLYHLGQSMVSSASKITCIG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DTWD1	Q8N5C7	88	136	89	304	Alternative sequence	ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLYHLGQSMVSSASKITCIG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DUSP10	Q9Y6W6	270	394	1	482	Chain	ID=PRO_0000094813;Note=Dual specificity protein phosphatase 10
DUSP10	Q9Y6W6	270	394	168	285	Domain	Note=Rhodanese;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00173
DUSP10	Q9Y6W6	270	394	384	453	Domain	Note=Tyrosine-protein phosphatase
DUSP10	Q9Y6W6	270	394	1	342	Alternative sequence	ID=VSP_036549;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DUSP10	Q9Y6W6	270	394	272	276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OUC
DUSP10	Q9Y6W6	270	394	277	279	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OUC
DUSP10	Q9Y6W6	270	394	281	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OUC
DUSP10	Q9Y6W6	270	394	284	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OUC
DUSP10	Q9Y6W6	270	394	323	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	329	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	336	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	340	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	348	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	356	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	363	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	368	372	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	378	380	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	384	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP10	Q9Y6W6	270	394	387	399	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZZW
DUSP19	Q8WTR2	91	142	1	217	Chain	ID=PRO_0000094832;Note=Dual specificity protein phosphatase 19
DUSP19	Q8WTR2	91	142	133	197	Domain	Note=Tyrosine-protein phosphatase
DUSP19	Q8WTR2	91	142	91	141	Alternative sequence	ID=VSP_005138;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11959862;Dbxref=PMID:11959862
DUSP19	Q8WTR2	91	142	94	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S4E
DUSP19	Q8WTR2	91	142	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S4E
DUSP19	Q8WTR2	91	142	107	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S4E
DUSP19	Q8WTR2	91	142	110	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S4E
DUSP19	Q8WTR2	91	142	125	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S4E
DUSP19	Q8WTR2	91	142	129	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S4E
DUSP22	Q9NRW4	63	87	2	184	Chain	ID=PRO_0000244751;Note=Dual specificity protein phosphatase 22
DUSP22	Q9NRW4	63	87	65	133	Domain	Note=Tyrosine-protein phosphatase
DUSP22	Q9NRW4	63	87	64	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WOH
DUSP22	Q9NRW4	63	87	67	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WOH
DUSP22	Q9NRW4	63	87	83	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WOH
E2F5	Q15329	294	310	1	346	Chain	ID=PRO_0000219469;Note=Transcription factor E2F5
E2F5	Q15329	294	310	287	346	Region	Note=Transactivation;Ontology_term=ECO:0000255;evidence=ECO:0000255
E2F5	Q15329	294	310	295	295	Alternative sequence	ID=VSP_040098;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7892279,ECO:0000303|PubMed:8589754;Dbxref=PMID:7892279,PMID:8589754
SLC1A3	P43003	60	106	1	542	Chain	ID=PRO_0000202057;Note=Excitatory amino acid transporter 1
SLC1A3	P43003	287	364	1	542	Chain	ID=PRO_0000202057;Note=Excitatory amino acid transporter 1
SLC1A3	P43003	365	429	1	542	Chain	ID=PRO_0000202057;Note=Excitatory amino acid transporter 1
SLC1A3	P43003	430	474	1	542	Chain	ID=PRO_0000202057;Note=Excitatory amino acid transporter 1
SLC1A3	P43003	60	106	48	68	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	60	106	69	86	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	60	106	87	108	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	287	364	270	297	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	287	364	298	318	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	287	364	319	340	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	287	364	341	345	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	287	364	346	376	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	346	376	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	377	385	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	386	412	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	413	425	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	426	459	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	430	474	426	459	Intramembrane	Note=Discontinuously helical;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	430	474	460	472	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	430	474	473	494	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	287	364	363	365	Region	Note=Aspartate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LM4,ECO:0000269|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	363	365	Region	Note=Aspartate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LM4,ECO:0000269|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	430	474	443	447	Region	Note=Aspartate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LM4,ECO:0000269|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	394	394	Metal binding	Note=Sodium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O59010
SLC1A3	P43003	365	429	396	396	Metal binding	Note=Sodium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LM4,ECO:0000269|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	365	429	398	398	Metal binding	Note=Sodium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O59010
SLC1A3	P43003	365	429	402	402	Binding site	Note=Aspartate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LM4,ECO:0000269|PubMed:28424515;Dbxref=PMID:28424515
SLC1A3	P43003	430	474	430	475	Alternative sequence	ID=VSP_043913;Note=In isoform 2. SITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFL->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16042756;Dbxref=PMID:16042756
SLC1A3	P43003	287	364	290	290	Natural variant	ID=VAR_031733;Note=In EA6. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116111;Dbxref=dbSNP:rs137852619,PMID:16116111
SLC1A3	P43003	287	364	363	363	Mutagenesis	Note=Loss of electrogenic glutamate transport. Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions%3B when associated with M-477. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20477940;Dbxref=PMID:20477940
SLC1A3	P43003	365	429	366	366	Sequence conflict	Note=S->CT;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC1A3	P43003	60	106	76	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	60	106	83	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	60	106	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	60	106	106	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	287	364	283	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	287	364	316	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	287	364	332	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	287	364	347	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	287	364	353	362	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	365	367	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	369	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	378	380	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	387	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	400	407	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	411	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	365	429	424	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	430	474	424	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	430	474	446	449	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	430	474	451	456	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	430	474	462	464	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
SLC1A3	P43003	430	474	465	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM4
EZR	P15311	184	232	1	586	Chain	ID=PRO_0000219408;Note=Ezrin
EZR	P15311	32	64	1	586	Chain	ID=PRO_0000219408;Note=Ezrin
EZR	P15311	184	232	1	586	Chain	ID=PRO_0000219408;Note=Ezrin
EZR	P15311	32	64	1	586	Chain	ID=PRO_0000219408;Note=Ezrin
EZR	P15311	4	32	1	586	Chain	ID=PRO_0000219408;Note=Ezrin
EZR	P15311	184	232	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EZR	P15311	32	64	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EZR	P15311	184	232	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EZR	P15311	32	64	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EZR	P15311	4	32	2	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EZR	P15311	32	64	60	60	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
EZR	P15311	32	64	60	60	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
EZR	P15311	4	32	5	10	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	4	32	15	20	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	26	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	26	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	4	32	26	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	45	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	45	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	32	64	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RM8
EZR	P15311	32	64	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RM8
EZR	P15311	184	232	184	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	184	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	199	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	199	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	204	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	204	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	215	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	215	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	224	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
EZR	P15311	184	232	224	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RMA
FAM118A	Q9NWS6	100	174	1	357	Chain	ID=PRO_0000079572;Note=Protein FAM118A
FAM118A	Q9NWS6	174	217	1	357	Chain	ID=PRO_0000079572;Note=Protein FAM118A
FAM118A	Q9NWS6	312	323	1	357	Chain	ID=PRO_0000079572;Note=Protein FAM118A
FAM118A	Q9NWS6	100	174	1	357	Chain	ID=PRO_0000079572;Note=Protein FAM118A
FAM118A	Q9NWS6	174	217	1	357	Chain	ID=PRO_0000079572;Note=Protein FAM118A
FAM118A	Q9NWS6	312	323	1	357	Chain	ID=PRO_0000079572;Note=Protein FAM118A
FAM118A	Q9NWS6	100	174	1	182	Alternative sequence	ID=VSP_056990;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM118A	Q9NWS6	174	217	1	182	Alternative sequence	ID=VSP_056990;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM118A	Q9NWS6	100	174	1	182	Alternative sequence	ID=VSP_056990;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM118A	Q9NWS6	174	217	1	182	Alternative sequence	ID=VSP_056990;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM118A	Q9NWS6	100	174	129	129	Natural variant	ID=VAR_022808;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15461802,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11556482,PMID:14702039,PMID:15461802,PMID:15489334
FAM118A	Q9NWS6	100	174	129	129	Natural variant	ID=VAR_022808;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15461802,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11556482,PMID:14702039,PMID:15461802,PMID:15489334
FAM118A	Q9NWS6	174	217	195	195	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM118A	Q9NWS6	174	217	195	195	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EXTL1	Q92935	291	327	1	676	Chain	ID=PRO_0000149653;Note=Exostosin-like 1
EXTL1	Q92935	477	506	1	676	Chain	ID=PRO_0000149653;Note=Exostosin-like 1
EXTL1	Q92935	291	327	31	676	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EXTL1	Q92935	477	506	31	676	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM126B	Q8IXS8	177	208	1	530	Chain	ID=PRO_0000278094;Note=Protein FAM126B
FAM126B	Q8IXS8	51	111	1	530	Chain	ID=PRO_0000278094;Note=Protein FAM126B
FAM172A	Q8WUF8	302	341	19	416	Chain	ID=PRO_0000320931;Note=Cotranscriptional regulator FAM172A
FAM172A	Q8WUF8	189	262	19	416	Chain	ID=PRO_0000320931;Note=Cotranscriptional regulator FAM172A
FAM172A	Q8WUF8	125	189	19	416	Chain	ID=PRO_0000320931;Note=Cotranscriptional regulator FAM172A
FAM172A	Q8WUF8	103	125	19	416	Chain	ID=PRO_0000320931;Note=Cotranscriptional regulator FAM172A
FAM172A	Q8WUF8	189	262	126	189	Alternative sequence	ID=VSP_043314;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM172A	Q8WUF8	125	189	126	189	Alternative sequence	ID=VSP_043314;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FAM172A	Q8WUF8	302	341	263	416	Alternative sequence	ID=VSP_031749;Note=In isoform 2. ENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL->VSEITTFLYYFLYLVYILLYVDCFVFLQEY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
FAM172A	Q8WUF8	125	189	131	131	Natural variant	ID=VAR_039312;Note=S->N;Dbxref=dbSNP:rs17083426
FAM172A	Q8WUF8	189	262	228	228	Natural variant	ID=VAR_080593;Note=Found in patients with CHARGES%3B unknown pathological significance. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29311329;Dbxref=dbSNP:rs767629211,PMID:29311329
FAM172A	Q8WUF8	302	341	307	416	Natural variant	ID=VAR_080594;Note=Found in a patient with CHARGES%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29311329;Dbxref=PMID:29311329
FAM172A	Q8WUF8	189	262	236	236	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM193A	P78312	402	486	1	1265	Chain	ID=PRO_0000089430;Note=Protein FAM193A
FAM193A	P78312	801	878	1	1265	Chain	ID=PRO_0000089430;Note=Protein FAM193A
FAM193A	P78312	1166	1207	1	1265	Chain	ID=PRO_0000089430;Note=Protein FAM193A
FAM193A	P78312	801	878	873	932	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM193A	P78312	801	878	793	1265	Alternative sequence	ID=VSP_014617;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734812;Dbxref=PMID:9734812
FAM193A	P78312	1166	1207	793	1265	Alternative sequence	ID=VSP_014617;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734812;Dbxref=PMID:9734812
FAM193A	P78312	1166	1207	1167	1207	Alternative sequence	ID=VSP_014615;Note=In isoform 2%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9734812;Dbxref=PMID:15489334,PMID:9734812
F11	P03951	493	525	388	625	Chain	ID=PRO_0000027826;Note=Coagulation factor XIa light chain
F11	P03951	493	525	388	623	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
F11	P03951	493	525	380	500	Disulfide bond	Note=Interchain (between heavy and light chains)
F11	P03951	493	525	514	581	Disulfide bond	.
F11	P03951	493	525	493	493	Natural variant	ID=VAR_012095;Note=In FA11D. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10606881;Dbxref=PMID:10606881
F11	P03951	493	525	503	503	Natural variant	ID=VAR_067949;Note=In FA11D. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005151;Dbxref=dbSNP:rs140068026,PMID:18005151
F11	P03951	493	525	506	506	Natural variant	ID=VAR_067950;Note=In FA11D%3B mild phenotype. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22016685;Dbxref=dbSNP:rs281875258,PMID:22016685
F11	P03951	493	525	511	511	Natural variant	ID=VAR_054902;Note=In FA11D%3B transfected cells contain reduced amount of mutant protein and display decreased secretion. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11895778;Dbxref=dbSNP:rs281875278,PMID:11895778
F11	P03951	493	525	514	514	Natural variant	ID=VAR_067951;Note=In FA11D. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22159456;Dbxref=dbSNP:rs281875249,PMID:22159456
F11	P03951	493	525	494	496	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6P
F11	P03951	493	525	504	506	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRG
F11	P03951	493	525	508	510	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AOD
F11	P03951	493	525	514	519	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRG
F11	P03951	493	525	522	525	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRG
PFKFB2	O60825	407	428	2	505	Chain	ID=PRO_0000179964;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 2
PFKFB2	O60825	407	428	249	505	Region	Note=Fructose-2%2C6-bisphosphatase
PFKFB2	O60825	407	428	428	428	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875
PFKFB2	O60825	407	428	427	427	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PFKFB2	O60825	407	428	407	409	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HTK
PFKFB2	O60825	407	428	410	412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HTK
PFKFB2	O60825	407	428	419	426	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HTK
FAM207A	Q9NSI2	94	117	1	230	Chain	ID=PRO_0000079528;Note=Protein FAM207A
FAM207A	Q9NSI2	167	189	1	230	Chain	ID=PRO_0000079528;Note=Protein FAM207A
FAM207A	Q9NSI2	94	117	81	95	Alternative sequence	ID=VSP_003831;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
FABP1	P07148	80	111	1	127	Chain	ID=PRO_0000067334;Note=Fatty acid-binding protein%2C liver
FABP1	P07148	80	111	90	90	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12710
FABP1	P07148	80	111	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12710
FABP1	P07148	80	111	94	94	Natural variant	ID=VAR_022093;Note=Polymorphism%3B increases the binding for cholesterol%3B increases high density lipoprotein (HDL)- and low density lipoprotein (LDL)-mediated cholesterol uptake. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3838313;Dbxref=dbSNP:rs2241883,PMID:3838313
FABP1	P07148	80	111	78	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VG7
FABP1	P07148	80	111	84	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VG7
FABP1	P07148	80	111	90	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VG7
FABP1	P07148	80	111	98	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VG7
FABP1	P07148	80	111	108	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VG7
FAR2	Q96K12	122	181	1	515	Chain	ID=PRO_0000261401;Note=Fatty acyl-CoA reductase 2
FAR2	Q96K12	122	181	1	515	Chain	ID=PRO_0000261401;Note=Fatty acyl-CoA reductase 2
FAR2	Q96K12	122	181	1	464	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24108123;Dbxref=PMID:24108123
FAR2	Q96K12	122	181	1	464	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24108123;Dbxref=PMID:24108123
FAR2	Q96K12	122	181	167	167	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAR2	Q96K12	122	181	167	167	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAHD2B	Q6P2I3	154	174	1	314	Chain	ID=PRO_0000289796;Note=Fumarylacetoacetate hydrolase domain-containing protein 2B
FAHD2B	Q6P2I3	154	174	1	314	Chain	ID=PRO_0000289796;Note=Fumarylacetoacetate hydrolase domain-containing protein 2B
FAHD2B	Q6P2I3	154	174	159	159	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6P587
FAHD2B	Q6P2I3	154	174	159	159	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6P587
FAHD2B	Q6P2I3	154	174	161	161	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6P587
FAHD2B	Q6P2I3	154	174	161	161	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6P587
FANCI	Q9NVI1	294	325	1	1328	Chain	ID=PRO_0000248376;Note=Fanconi anemia group I protein
FANCI	Q9NVI1	764	818	1	1328	Chain	ID=PRO_0000248376;Note=Fanconi anemia group I protein
FANCI	Q9NVI1	903	942	1	1328	Chain	ID=PRO_0000248376;Note=Fanconi anemia group I protein
FANCI	Q9NVI1	1137	1157	1	1328	Chain	ID=PRO_0000248376;Note=Fanconi anemia group I protein
FANCI	Q9NVI1	1212	1248	1	1328	Chain	ID=PRO_0000248376;Note=Fanconi anemia group I protein
FANCI	Q9NVI1	294	325	253	1328	Alternative sequence	ID=VSP_035606;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCI	Q9NVI1	764	818	253	1328	Alternative sequence	ID=VSP_035606;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCI	Q9NVI1	903	942	253	1328	Alternative sequence	ID=VSP_035606;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCI	Q9NVI1	1137	1157	253	1328	Alternative sequence	ID=VSP_035606;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FANCI	Q9NVI1	1212	1248	253	1328	Alternative sequence	ID=VSP_035606;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FAT4	Q6V0I7	3931	3966	39	4981	Chain	ID=PRO_0000324637;Note=Protocadherin Fat 4
FAT4	Q6V0I7	3931	3966	39	4504	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAT4	Q6V0I7	3931	3966	3900	3936	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FAT4	Q6V0I7	3931	3966	3938	3974	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
FAT4	Q6V0I7	3931	3966	3926	3935	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAT4	Q6V0I7	3931	3966	3942	3953	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAT4	Q6V0I7	3931	3966	3947	3962	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAT4	Q6V0I7	3931	3966	3964	3973	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
FAT4	Q6V0I7	3931	3966	3932	3966	Alternative sequence	ID=VSP_032336;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15003449;Dbxref=PMID:15003449
DDB2	Q92466	88	152	1	427	Chain	ID=PRO_0000050953;Note=DNA damage-binding protein 2
DDB2	Q92466	88	152	116	151	Repeat	Note=WD 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:19109893;Dbxref=PMID:19109893
DDB2	Q92466	88	152	87	98	Region	Note=Required for interaction with DDB1
DDB2	Q92466	88	152	89	152	Alternative sequence	ID=VSP_014674;Note=In isoform D3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14751237;Dbxref=PMID:14751237
DDB2	Q92466	88	152	83	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	96	102	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	106	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	114	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	127	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	136	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDB2	Q92466	88	152	148	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E54
DDA1	Q9BW61	1	28	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
DDA1	Q9BW61	1	28	2	102	Chain	ID=PRO_0000310270;Note=DET1- and DDB1-associated protein 1
DDA1	Q9BW61	1	28	2	2	Modified residue	Note=N-acetylalanine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
DDC	P20711	380	414	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	347	380	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	190	238	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	67	105	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	380	414	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	347	380	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	190	238	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	67	105	1	480	Chain	ID=PRO_0000146939;Note=Aromatic-L-amino-acid decarboxylase
DDC	P20711	67	105	58	115	Repeat	Note=1
DDC	P20711	67	105	58	115	Repeat	Note=1
DDC	P20711	67	105	58	178	Region	Note=2 X approximate tandem repeats
DDC	P20711	67	105	58	178	Region	Note=2 X approximate tandem repeats
DDC	P20711	67	105	82	82	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DDC	P20711	67	105	82	82	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DDC	P20711	190	238	192	192	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DDC	P20711	190	238	192	192	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DDC	P20711	67	105	68	145	Alternative sequence	ID=VSP_047175;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDC	P20711	67	105	68	145	Alternative sequence	ID=VSP_047175;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDC	P20711	190	238	146	238	Alternative sequence	ID=VSP_047176;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDC	P20711	190	238	146	238	Alternative sequence	ID=VSP_047176;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDC	P20711	380	414	339	480	Alternative sequence	ID=VSP_046570;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15532536;Dbxref=PMID:15532536
DDC	P20711	347	380	339	480	Alternative sequence	ID=VSP_046570;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15532536;Dbxref=PMID:15532536
DDC	P20711	380	414	339	480	Alternative sequence	ID=VSP_046570;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15532536;Dbxref=PMID:15532536
DDC	P20711	347	380	339	480	Alternative sequence	ID=VSP_046570;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15532536;Dbxref=PMID:15532536
DDC	P20711	67	105	91	91	Natural variant	ID=VAR_046138;Note=In AADCD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12;Dbxref=dbSNP:rs137853211
DDC	P20711	67	105	91	91	Natural variant	ID=VAR_046138;Note=In AADCD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12;Dbxref=dbSNP:rs137853211
DDC	P20711	67	105	102	102	Natural variant	ID=VAR_019309;Note=In AADCD. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14991824,ECO:0000269|Ref.12;Dbxref=dbSNP:rs137853207,PMID:14991824
DDC	P20711	67	105	102	102	Natural variant	ID=VAR_019309;Note=In AADCD. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14991824,ECO:0000269|Ref.12;Dbxref=dbSNP:rs137853207,PMID:14991824
DDC	P20711	190	238	210	210	Natural variant	ID=VAR_014789;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|Ref.5;Dbxref=dbSNP:rs6262,PMID:10391209
DDC	P20711	190	238	210	210	Natural variant	ID=VAR_014789;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|Ref.5;Dbxref=dbSNP:rs6262,PMID:10391209
DDC	P20711	190	238	217	217	Natural variant	ID=VAR_014790;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|Ref.5;Dbxref=dbSNP:rs6263,PMID:10391209
DDC	P20711	190	238	217	217	Natural variant	ID=VAR_014790;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|Ref.5;Dbxref=dbSNP:rs6263,PMID:10391209
DDC	P20711	347	380	347	347	Natural variant	ID=VAR_046143;Note=In AADCD. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15079002;Dbxref=dbSNP:rs201951824,PMID:15079002
DDC	P20711	347	380	347	347	Natural variant	ID=VAR_046143;Note=In AADCD. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15079002;Dbxref=dbSNP:rs201951824,PMID:15079002
DDC	P20711	380	414	408	408	Natural variant	ID=VAR_046144;Note=In AADCD. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15079002;Dbxref=PMID:15079002
DDC	P20711	380	414	408	408	Natural variant	ID=VAR_046144;Note=In AADCD. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15079002;Dbxref=PMID:15079002
DDC	P20711	67	105	65	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	67	105	65	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	67	105	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	67	105	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	67	105	86	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	67	105	86	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	67	105	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBL
DDC	P20711	67	105	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RBL
DDC	P20711	190	238	193	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	193	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	219	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	219	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	235	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	190	238	235	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	380	414	359	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	347	380	359	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	380	414	359	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	347	380	359	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	380	414	398	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	380	414	398	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	380	414	406	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DDC	P20711	380	414	406	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RCH
DEDD2	Q8WXF8	149	196	1	326	Chain	ID=PRO_0000191277;Note=DNA-binding death effector domain-containing protein 2
DEDD2	Q8WXF8	149	196	1	326	Chain	ID=PRO_0000191277;Note=DNA-binding death effector domain-containing protein 2
DEDD2	Q8WXF8	149	196	155	173	Motif	Note=Bipartite nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DEDD2	Q8WXF8	149	196	155	173	Motif	Note=Bipartite nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DEDD2	Q8WXF8	149	196	145	149	Alternative sequence	ID=VSP_010312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12235123,ECO:0000303|PubMed:15489334;Dbxref=PMID:12235123,PMID:15489334
DEDD2	Q8WXF8	149	196	145	149	Alternative sequence	ID=VSP_010312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12235123,ECO:0000303|PubMed:15489334;Dbxref=PMID:12235123,PMID:15489334
DMTN	Q08495	6	31	1	405	Chain	ID=PRO_0000218755;Note=Dematin
DMTN	Q08495	319	341	1	405	Chain	ID=PRO_0000218755;Note=Dematin
DMTN	Q08495	6	31	1	405	Chain	ID=PRO_0000218755;Note=Dematin
DMTN	Q08495	6	31	1	405	Chain	ID=PRO_0000218755;Note=Dematin
DMTN	Q08495	6	31	1	405	Chain	ID=PRO_0000218755;Note=Dematin
DMTN	Q08495	319	341	1	405	Chain	ID=PRO_0000218755;Note=Dematin
DMTN	Q08495	319	341	337	405	Domain	Note=HP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00595
DMTN	Q08495	319	341	337	405	Domain	Note=HP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00595
DMTN	Q08495	6	31	16	16	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	16	16	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	16	16	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	16	16	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	18	18	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	18	18	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	18	18	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	18	18	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DMTN	Q08495	6	31	26	26	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DMTN	Q08495	6	31	26	26	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DMTN	Q08495	6	31	26	26	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DMTN	Q08495	6	31	26	26	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DMTN	Q08495	319	341	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:23186163
DMTN	Q08495	319	341	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:23186163
DMTN	Q08495	6	31	7	31	Alternative sequence	ID=VSP_044803;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DMTN	Q08495	6	31	7	31	Alternative sequence	ID=VSP_044803;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DMTN	Q08495	6	31	7	31	Alternative sequence	ID=VSP_044803;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DMTN	Q08495	6	31	7	31	Alternative sequence	ID=VSP_044803;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DMTN	Q08495	319	341	320	341	Alternative sequence	ID=VSP_004189;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8341682;Dbxref=PMID:14702039,PMID:15489334,PMID:8341682
DMTN	Q08495	319	341	320	341	Alternative sequence	ID=VSP_004189;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8341682;Dbxref=PMID:14702039,PMID:15489334,PMID:8341682
DMTN	Q08495	319	341	333	333	Mutagenesis	Note=Reduces interaction with plasmodium berghei 14-3-3 protein. Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein%3B when associated with A-124 and A-403. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21084299;Dbxref=PMID:21084299
DMTN	Q08495	319	341	333	333	Mutagenesis	Note=Reduces interaction with plasmodium berghei 14-3-3 protein. Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein%3B when associated with A-124 and A-403. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21084299;Dbxref=PMID:21084299
DENND5B	Q6ZUT9	851	893	2	1274	Chain	ID=PRO_0000326531;Note=DENN domain-containing protein 5B
DENND5B	Q6ZUT9	364	543	2	1274	Chain	ID=PRO_0000326531;Note=DENN domain-containing protein 5B
DENND5B	Q6ZUT9	364	543	263	399	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND5B	Q6ZUT9	364	543	401	581	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND5B	Q6ZUT9	851	893	772	932	Domain	Note=RUN 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00178
DENND5B	Q6ZUT9	851	893	586	1274	Alternative sequence	ID=VSP_032676;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DENND5B	Q6ZUT9	851	893	717	1274	Alternative sequence	ID=VSP_032678;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DENND5B	Q6ZUT9	364	543	487	487	Natural variant	ID=VAR_040077;Note=H->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1056320,PMID:14702039
DENND5B	Q6ZUT9	364	543	434	434	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND5B	Q6ZUT9	364	543	480	480	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND5B	Q6ZUT9	364	543	538	538	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
DERA	Q9Y315	169	212	1	318	Chain	ID=PRO_0000057310;Note=Deoxyribose-phosphate aldolase
DERA	Q9Y315	250	300	1	318	Chain	ID=PRO_0000057310;Note=Deoxyribose-phosphate aldolase
DERA	Q9Y315	250	300	254	254	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25229427;Dbxref=PMID:25229427
DERA	Q9Y315	250	300	254	254	Mutagenesis	Note=Abolishes deoxyribose-phosphate aldolase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25229427;Dbxref=PMID:25229427
DBN1	Q16643	257	277	2	649	Chain	ID=PRO_0000080008;Note=Drebrin
DBN1	Q16643	110	159	2	649	Chain	ID=PRO_0000080008;Note=Drebrin
DBN1	Q16643	110	159	3	134	Domain	Note=ADF-H;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00599
DBN1	Q16643	110	159	141	141	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
DBN1	Q16643	110	159	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.8;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
DBN1	Q16643	110	159	114	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y1Z
DBN1	Q16643	110	159	121	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y1Z
DBN1	Q16643	110	159	126	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y1Z
FKBP2	P26885	110	122	22	142	Chain	ID=PRO_0000025506;Note=Peptidyl-prolyl cis-trans isomerase FKBP2
FKBP2	P26885	110	122	22	142	Chain	ID=PRO_0000025506;Note=Peptidyl-prolyl cis-trans isomerase FKBP2
FKBP2	P26885	110	122	22	142	Chain	ID=PRO_0000025506;Note=Peptidyl-prolyl cis-trans isomerase FKBP2
FKBP2	P26885	110	122	49	137	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP2	P26885	110	122	49	137	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP2	P26885	110	122	49	137	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP2	P26885	110	122	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	111	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	111	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	111	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP2	P26885	110	122	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PBC
FKBP3	Q00688	70	106	2	224	Chain	ID=PRO_0000075307;Note=Peptidyl-prolyl cis-trans isomerase FKBP3
FKBP3	Q00688	36	70	2	224	Chain	ID=PRO_0000075307;Note=Peptidyl-prolyl cis-trans isomerase FKBP3
FKBP3	Q00688	70	106	2	224	Chain	ID=PRO_0000075307;Note=Peptidyl-prolyl cis-trans isomerase FKBP3
FKBP3	Q00688	36	70	2	224	Chain	ID=PRO_0000075307;Note=Peptidyl-prolyl cis-trans isomerase FKBP3
FKBP3	Q00688	36	70	36	36	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
FKBP3	Q00688	36	70	36	36	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
FKBP3	Q00688	70	106	99	99	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62446
FKBP3	Q00688	70	106	99	99	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62446
FKBP3	Q00688	36	70	35	40	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KFV
FKBP3	Q00688	36	70	35	40	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KFV
FKBP3	Q00688	36	70	47	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KFV
FKBP3	Q00688	36	70	47	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KFV
FKBP3	Q00688	36	70	56	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KFV
FKBP3	Q00688	36	70	56	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KFV
FLNA	P21333	2517	2585	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	2444	2517	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	2126	2167	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	2007	2075	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	1895	1953	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	1852	1895	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	1739	1771	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	476	522	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	409	476	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
FLNA	P21333	409	476	376	474	Repeat	Note=Filamin 2
FLNA	P21333	476	522	475	570	Repeat	Note=Filamin 3
FLNA	P21333	409	476	475	570	Repeat	Note=Filamin 3
FLNA	P21333	1739	1771	1649	1740	Repeat	Note=Filamin 15
FLNA	P21333	1852	1895	1779	1860	Repeat	Note=Filamin 16
FLNA	P21333	1895	1953	1861	1950	Repeat	Note=Filamin 17
FLNA	P21333	1852	1895	1861	1950	Repeat	Note=Filamin 17
FLNA	P21333	2007	2075	1951	2039	Repeat	Note=Filamin 18
FLNA	P21333	1895	1953	1951	2039	Repeat	Note=Filamin 18
FLNA	P21333	2126	2167	2042	2131	Repeat	Note=Filamin 19
FLNA	P21333	2007	2075	2042	2131	Repeat	Note=Filamin 19
FLNA	P21333	2126	2167	2132	2230	Repeat	Note=Filamin 20
FLNA	P21333	2444	2517	2424	2516	Repeat	Note=Filamin 23
FLNA	P21333	2517	2585	2552	2646	Repeat	Note=Filamin 24
FLNA	P21333	1739	1771	1741	1778	Region	Note=Hinge 1
FLNA	P21333	2517	2585	2517	2647	Region	Note=Self-association site%2C tail
FLNA	P21333	2444	2517	2517	2647	Region	Note=Self-association site%2C tail
FLNA	P21333	2517	2585	2517	2551	Region	Note=Hinge 2
FLNA	P21333	2444	2517	2517	2551	Region	Note=Hinge 2
FLNA	P21333	1739	1771	1761	1762	Site	Note=Cleavage%3B by calpain
FLNA	P21333	476	522	508	508	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FLNA	P21333	2007	2075	2053	2053	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
FLNA	P21333	2126	2167	2128	2128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FLNA	P21333	2126	2167	2152	2152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:25666618,ECO:0000269|PubMed:26460884;Dbxref=PMID:17081983,PMID:18088087,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569,PMID:25666618,PMID:26460884
FLNA	P21333	2126	2167	2158	2158	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18088087,PMID:23186163,PMID:24275569
FLNA	P21333	2126	2167	2163	2163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
FLNA	P21333	2444	2517	2510	2510	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
FLNA	P21333	2517	2585	2523	2523	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTM8
FLNA	P21333	2517	2585	2526	2526	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTM8
FLNA	P21333	2517	2585	2569	2569	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTM8
FLNA	P21333	2517	2585	2569	2569	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTM8
FLNA	P21333	2517	2585	2575	2575	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTM8
FLNA	P21333	409	476	429	429	Natural variant	ID=VAR_069803;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12612583;Dbxref=dbSNP:rs36051194,PMID:12612583
FLNA	P21333	1739	1771	1724	1739	Natural variant	ID=VAR_064159;Note=In TOD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20598277;Dbxref=PMID:20598277
FLNA	P21333	1739	1771	1764	1764	Natural variant	ID=VAR_012835;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11532987,ECO:0000269|PubMed:12612583;Dbxref=dbSNP:rs57108893,PMID:11532987,PMID:12612583
FLNA	P21333	476	522	480	482	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M9P
FLNA	P21333	476	522	484	487	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M9P
FLNA	P21333	476	522	488	490	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M9P
FLNA	P21333	476	522	501	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M9P
FLNA	P21333	476	522	515	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M9P
FLNA	P21333	1852	1895	1855	1860	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K7P
FLNA	P21333	1852	1895	1865	1867	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K7P
FLNA	P21333	1852	1895	1869	1872	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1852	1895	1873	1875	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1852	1895	1877	1879	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1852	1895	1884	1889	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1852	1895	1891	1893	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AAV
FLNA	P21333	1895	1953	1895	1906	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1852	1895	1895	1906	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1895	1953	1909	1914	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1895	1953	1916	1925	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1895	1953	1930	1938	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	1895	1953	1947	1953	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP3
FLNA	P21333	2007	2075	2007	2010	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K7Q
FLNA	P21333	2007	2075	2014	2025	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K7Q
FLNA	P21333	2007	2075	2034	2039	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K7Q
FLNA	P21333	2007	2075	2041	2043	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K7Q
FLNA	P21333	2007	2075	2047	2049	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2007	2075	2051	2054	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2007	2075	2055	2057	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2007	2075	2059	2061	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2007	2075	2066	2071	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2007	2075	2075	2077	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2126	2167	2129	2136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2126	2167	2139	2148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J3S
FLNA	P21333	2126	2167	2161	2165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P3W
FLNA	P21333	2444	2517	2448	2453	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2444	2517	2455	2457	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2444	2517	2462	2470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2444	2517	2472	2479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2444	2517	2482	2489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2444	2517	2491	2506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2517	2585	2511	2518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2444	2517	2511	2518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K3T
FLNA	P21333	2517	2585	2561	2564	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CNK
FLNA	P21333	2517	2585	2565	2567	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CNK
FLNA	P21333	2517	2585	2576	2581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CNK
CACFD1	Q9UGQ2	65	106	1	172	Chain	ID=PRO_0000089671;Note=Calcium channel flower homolog
CACFD1	Q9UGQ2	65	106	58	78	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACFD1	Q9UGQ2	65	106	103	123	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACFD1	Q9UGQ2	65	106	65	107	Alternative sequence	ID=VSP_012997;Note=In isoform 2 and isoform 3. IMNAFILLLCEAPFCCQFIEFANTVAEKVDRLRSWQKAVFYCG->M;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16303743;Dbxref=PMID:14702039,PMID:16303743
FMNL1	O95466	43	71	2	1100	Chain	ID=PRO_0000194890;Note=Formin-like protein 1
FMNL1	O95466	964	998	2	1100	Chain	ID=PRO_0000194890;Note=Formin-like protein 1
FMNL1	O95466	43	71	27	468	Domain	Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579
FMNL1	O95466	964	998	632	1023	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
FOXK2	Q01167	140	204	2	660	Chain	ID=PRO_0000091858;Note=Forkhead box protein K2
FOXK2	Q01167	254	303	2	660	Chain	ID=PRO_0000091858;Note=Forkhead box protein K2
FOXK2	Q01167	254	303	258	353	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXK2	Q01167	140	204	129	171	Region	Note=Required for interaction with DVL2 and SUDS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	254	303	300	318	Region	Note=DNA-binding%3B major groove
FOXK2	Q01167	140	204	144	144	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
FOXK2	Q01167	140	204	161	161	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FOXK2	Q01167	140	204	164	164	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FOXK2	Q01167	140	204	141	141	Mutagenesis	Note=No effect on interaction with DVL2. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	142	142	Mutagenesis	Note=No effect on interaction with DVL2. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	145	145	Mutagenesis	Note=Abolishes interaction with DVL2 and SUDS3 as well as DVL2 nuclear translocation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	146	146	Mutagenesis	Note=Highly reduces interaction with DVL2. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	147	147	Mutagenesis	Note=No effect on interaction with DVL2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	148	148	Mutagenesis	Note=No effect on interaction with DVL2. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	150	150	Mutagenesis	Note=No effect on interaction with DVL2. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	151	151	Mutagenesis	Note=No effect on interaction with DVL2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	152	152	Mutagenesis	Note=No effect on interaction with DVL2. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	154	154	Mutagenesis	Note=Abolishes interaction with DVL2 and SUDS3 as well as DVL2 nuclear translocation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	155	155	Mutagenesis	Note=No effect on interaction with DVL2. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	140	204	157	157	Mutagenesis	Note=No effect on interaction with DVL2. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25805136;Dbxref=PMID:25805136
FOXK2	Q01167	254	303	258	258	Mutagenesis	Note=Decreases DNA-binding to 40%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16624804;Dbxref=PMID:16624804
FOXK2	Q01167	254	303	300	300	Mutagenesis	Note=Decreases DNA-binding to 20%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16624804;Dbxref=PMID:16624804
FOXK2	Q01167	254	303	263	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C6Y
FOXK2	Q01167	254	303	277	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JXS
FOXK2	Q01167	254	303	281	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C6Y
FOXK2	Q01167	254	303	295	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JXS
FOXK2	Q01167	254	303	300	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C6Y
FRYL	O94915	2507	2563	2	3013	Chain	ID=PRO_0000277619;Note=Protein furry homolog-like
FRYL	O94915	2188	2235	2	3013	Chain	ID=PRO_0000277619;Note=Protein furry homolog-like
FRYL	O94915	2507	2563	2	3013	Chain	ID=PRO_0000277619;Note=Protein furry homolog-like
FRYL	O94915	2188	2235	2	3013	Chain	ID=PRO_0000277619;Note=Protein furry homolog-like
FRYL	O94915	2507	2563	1	2604	Alternative sequence	ID=VSP_023038;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FRYL	O94915	2188	2235	1	2604	Alternative sequence	ID=VSP_023038;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FRYL	O94915	2507	2563	1	2604	Alternative sequence	ID=VSP_023038;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FRYL	O94915	2188	2235	1	2604	Alternative sequence	ID=VSP_023038;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FSTL4	Q6MZW2	536	572	23	842	Chain	ID=PRO_0000251925;Note=Follistatin-related protein 4
FSTL4	Q6MZW2	53	136	23	842	Chain	ID=PRO_0000251925;Note=Follistatin-related protein 4
FSTL4	Q6MZW2	53	136	81	135	Domain	Note=Kazal-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL4	Q6MZW2	53	136	87	119	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL4	Q6MZW2	53	136	93	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL4	Q6MZW2	53	136	101	133	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FSTL4	Q6MZW2	53	136	78	246	Alternative sequence	ID=VSP_020800;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
FSTL4	Q6MZW2	53	136	60	60	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
FTO	Q9C0B1	250	298	1	505	Chain	ID=PRO_0000286163;Note=Alpha-ketoglutarate-dependent dioxygenase FTO
FTO	Q9C0B1	325	373	1	505	Chain	ID=PRO_0000286163;Note=Alpha-ketoglutarate-dependent dioxygenase FTO
FTO	Q9C0B1	250	298	32	327	Region	Note=Fe2OG dioxygenase domain
FTO	Q9C0B1	325	373	32	327	Region	Note=Fe2OG dioxygenase domain
FTO	Q9C0B1	250	298	295	295	Binding site	Note=Alpha-ketoglutarate
FTO	Q9C0B1	250	298	1	445	Alternative sequence	ID=VSP_025002;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	325	373	1	445	Alternative sequence	ID=VSP_025002;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	1	399	Alternative sequence	ID=VSP_025003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	325	373	1	399	Alternative sequence	ID=VSP_025003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	1	378	Alternative sequence	ID=VSP_025004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	325	373	1	378	Alternative sequence	ID=VSP_025004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	271	271	Natural variant	ID=VAR_076423;Note=Found in a patient with microcephaly%2C developmental delay%2C behavioral abnormalities%2C dysmorphic facial features%2C hypotonia and other various phenotypic abnormalities%3B unknown pathological significance. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26740239;Dbxref=PMID:26740239
FTO	Q9C0B1	250	298	271	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	250	298	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	250	298	284	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	250	298	293	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	325	373	327	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F8P
FTO	Q9C0B1	325	373	331	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	325	373	361	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FH	P07954	185	246	45	510	Chain	ID=PRO_0000010319;Note=Fumarate hydratase%2C mitochondrial
FH	P07954	185	246	186	188	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
FH	P07954	185	246	213	213	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97807
FH	P07954	185	246	223	223	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97807
FH	P07954	185	246	223	223	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97807
FH	P07954	185	246	185	185	Natural variant	ID=VAR_013500;Note=In HLRCC. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11865300;Dbxref=dbSNP:rs779707997,PMID:11865300
FH	P07954	185	246	230	230	Natural variant	ID=VAR_002445;Note=In FMRD and HLRCC. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11865300,ECO:0000269|PubMed:9635293;Dbxref=dbSNP:rs752232718,PMID:11865300,PMID:9635293
FH	P07954	185	246	233	233	Natural variant	ID=VAR_013501;Note=In HLRCC. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11865300;Dbxref=dbSNP:rs121913123,PMID:11865300
FH	P07954	185	246	187	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FH	P07954	185	246	190	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FH	P07954	185	246	207	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FH	P07954	185	246	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FH	P07954	185	246	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FH	P07954	185	246	237	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FH	P07954	185	246	244	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UPP
FUT8	Q9BYC5	361	419	1	575	Chain	ID=PRO_0000080526;Note=Alpha-(1%2C6)-fucosyltransferase
FUT8	Q9BYC5	361	419	1	575	Chain	ID=PRO_0000080526;Note=Alpha-(1%2C6)-fucosyltransferase
FUT8	Q9BYC5	361	419	31	575	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
FUT8	Q9BYC5	361	419	31	575	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
FUT8	Q9BYC5	361	419	206	493	Domain	Note=GT23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00992
FUT8	Q9BYC5	361	419	206	493	Domain	Note=GT23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00992
FUT8	Q9BYC5	361	419	365	366	Region	Note=Important for donor substrate binding
FUT8	Q9BYC5	361	419	365	366	Region	Note=Important for donor substrate binding
FUT8	Q9BYC5	361	419	15	420	Alternative sequence	ID=VSP_053362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14514715,ECO:0000303|PubMed:15489334;Dbxref=PMID:14514715,PMID:15489334
FUT8	Q9BYC5	361	419	15	420	Alternative sequence	ID=VSP_053362;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14514715,ECO:0000303|PubMed:15489334;Dbxref=PMID:14514715,PMID:15489334
FUT8	Q9BYC5	361	419	330	575	Alternative sequence	ID=VSP_001808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10814706;Dbxref=PMID:10814706
FUT8	Q9BYC5	361	419	330	575	Alternative sequence	ID=VSP_001808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10814706;Dbxref=PMID:10814706
FUT8	Q9BYC5	361	419	365	365	Mutagenesis	Note=Complete loss of activity. R->A%2CK;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10764839,ECO:0000269|PubMed:17172260;Dbxref=PMID:10764839,PMID:17172260
FUT8	Q9BYC5	361	419	365	365	Mutagenesis	Note=Complete loss of activity. R->A%2CK;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10764839,ECO:0000269|PubMed:17172260;Dbxref=PMID:10764839,PMID:17172260
FUT8	Q9BYC5	361	419	366	366	Mutagenesis	Note=Decreases activity to 3%25. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10764839;Dbxref=PMID:10764839
FUT8	Q9BYC5	361	419	366	366	Mutagenesis	Note=Decreases activity to 3%25. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10764839;Dbxref=PMID:10764839
FUT8	Q9BYC5	361	419	368	368	Mutagenesis	Note=Loss of enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	368	368	Mutagenesis	Note=Loss of enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	369	369	Mutagenesis	Note=Loss of enzyme activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	369	369	Mutagenesis	Note=Loss of enzyme activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	373	373	Mutagenesis	Note=Loss of enzyme activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	373	373	Mutagenesis	Note=Loss of enzyme activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	382	382	Mutagenesis	Note=Loss of enzyme activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	382	382	Mutagenesis	Note=Loss of enzyme activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	409	409	Mutagenesis	Note=Loss of enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	409	409	Mutagenesis	Note=Loss of enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	410	410	Mutagenesis	Note=No effect on enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	410	410	Mutagenesis	Note=No effect on enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17172260;Dbxref=PMID:17172260
FUT8	Q9BYC5	361	419	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	379	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	379	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	403	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	403	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	411	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FUT8	Q9BYC5	361	419	411	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DE0
FBXL17	Q9UF56	502	538	1	701	Chain	ID=PRO_0000119865;Note=F-box/LRR-repeat protein 17
FBXL17	Q9UF56	458	502	1	701	Chain	ID=PRO_0000119865;Note=F-box/LRR-repeat protein 17
FBXL17	Q9UF56	331	372	1	701	Chain	ID=PRO_0000119865;Note=F-box/LRR-repeat protein 17
FBXL17	Q9UF56	331	372	318	365	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXL17	Q9UF56	331	372	1	398	Alternative sequence	ID=VSP_037034;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
GPR137	Q96N19	211	261	1	417	Chain	ID=PRO_0000269996;Note=Integral membrane protein GPR137
GPR137	Q96N19	211	261	197	218	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137	Q96N19	211	261	219	241	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137	Q96N19	211	261	242	274	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137	Q96N19	211	261	257	257	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137	Q96N19	211	261	212	261	Alternative sequence	ID=VSP_022121;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GPR137	Q96N19	211	261	254	254	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOXRED2	Q8IWF2	260	349	27	684	Chain	ID=PRO_0000337692;Note=FAD-dependent oxidoreductase domain-containing protein 2
FOXRED2	Q8IWF2	260	349	27	684	Chain	ID=PRO_0000337692;Note=FAD-dependent oxidoreductase domain-containing protein 2
FOXRED2	Q8IWF2	260	349	27	684	Chain	ID=PRO_0000337692;Note=FAD-dependent oxidoreductase domain-containing protein 2
FOXRED2	Q8IWF2	260	349	1	327	Alternative sequence	ID=VSP_033997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FOXRED2	Q8IWF2	260	349	1	327	Alternative sequence	ID=VSP_033997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FOXRED2	Q8IWF2	260	349	1	327	Alternative sequence	ID=VSP_033997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FOXRED2	Q8IWF2	260	349	308	308	Natural variant	ID=VAR_043705;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15461802,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2277841,PMID:15461802,PMID:15489334
FOXRED2	Q8IWF2	260	349	308	308	Natural variant	ID=VAR_043705;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15461802,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2277841,PMID:15461802,PMID:15489334
FOXRED2	Q8IWF2	260	349	308	308	Natural variant	ID=VAR_043705;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15461802,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2277841,PMID:15461802,PMID:15489334
FOXRED2	Q8IWF2	260	349	345	345	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOXRED2	Q8IWF2	260	349	345	345	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOXRED2	Q8IWF2	260	349	345	345	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TUBGCP4	Q9UGJ1	338	355	1	667	Chain	ID=PRO_0000078124;Note=Gamma-tubulin complex component 4
TUBGCP4	Q9UGJ1	533	578	1	667	Chain	ID=PRO_0000078124;Note=Gamma-tubulin complex component 4
TUBGCP4	Q9UGJ1	578	617	1	667	Chain	ID=PRO_0000078124;Note=Gamma-tubulin complex component 4
TUBGCP4	Q9UGJ1	338	355	322	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	338	355	350	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	533	578	509	535	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	533	578	537	549	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	533	578	554	574	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	533	578	576	597	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	578	617	576	597	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
TUBGCP4	Q9UGJ1	578	617	606	635	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RIP
GCSH	P23434	97	141	49	173	Chain	ID=PRO_0000010723;Note=Glycine cleavage system H protein%2C mitochondrial
GCSH	P23434	97	141	66	148	Domain	Note=Lipoyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066
GCSH	P23434	97	141	107	107	Modified residue	Note=N6-lipoyllysine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01066,ECO:0000269|PubMed:1671321;Dbxref=PMID:1671321
GLDC	P23378	946	973	36	1020	Chain	ID=PRO_0000010740;Note=Glycine dehydrogenase (decarboxylating)%2C mitochondrial
GLDC	P23378	856	888	36	1020	Chain	ID=PRO_0000010740;Note=Glycine dehydrogenase (decarboxylating)%2C mitochondrial
GLDC	P23378	684	734	36	1020	Chain	ID=PRO_0000010740;Note=Glycine dehydrogenase (decarboxylating)%2C mitochondrial
GLDC	P23378	212	237	36	1020	Chain	ID=PRO_0000010740;Note=Glycine dehydrogenase (decarboxylating)%2C mitochondrial
GLDC	P23378	856	888	866	866	Natural variant	ID=VAR_078790;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183
GDI2	P50395	196	239	1	445	Chain	ID=PRO_0000056679;Note=Rab GDP dissociation inhibitor beta
GDI2	P50395	84	129	1	445	Chain	ID=PRO_0000056679;Note=Rab GDP dissociation inhibitor beta
GDI2	P50395	84	129	112	112	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GDI2	P50395	84	129	86	130	Alternative sequence	ID=VSP_043469;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GUCY1A2	P33402	402	564	1	732	Chain	ID=PRO_0000074113;Note=Guanylate cyclase soluble subunit alpha-2
GUCY1A2	P33402	402	564	521	648	Domain	Note=Guanylate cyclase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00099
GUCY1A2	P33402	402	564	402	402	Alternative sequence	ID=VSP_054154;Note=In isoform 3. K->KSKHVTEGHLTQLSVAGFNSLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GEMIN5	Q8TEQ6	836	877	1	1508	Chain	ID=PRO_0000051004;Note=Gem-associated protein 5
GEMIN5	Q8TEQ6	798	836	1	1508	Chain	ID=PRO_0000051004;Note=Gem-associated protein 5
GEMIN5	Q8TEQ6	722	798	1	1508	Chain	ID=PRO_0000051004;Note=Gem-associated protein 5
GEMIN5	Q8TEQ6	722	798	738	746	Compositional bias	Note=Poly-Lys
GEMIN5	Q8TEQ6	722	798	751	751	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN5	Q8TEQ6	722	798	757	757	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
GEMIN5	Q8TEQ6	722	798	770	770	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN5	Q8TEQ6	722	798	778	778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18691976,PMID:21406692,PMID:23186163
GEMIN5	Q8TEQ6	836	877	847	847	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN5	Q8TEQ6	722	798	754	754	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GHITM	Q9H3K2	197	260	46	345	Chain	ID=PRO_0000179119;Note=Growth hormone-inducible transmembrane protein
GHITM	Q9H3K2	197	260	191	211	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GHITM	Q9H3K2	197	260	212	213	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
GHITM	Q9H3K2	197	260	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GHITM	Q9H3K2	197	260	235	244	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
GHITM	Q9H3K2	197	260	245	265	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GID8	Q9NWU2	105	171	1	228	Chain	ID=PRO_0000079411;Note=Glucose-induced degradation protein 8 homolog
GID8	Q9NWU2	105	171	63	120	Domain	Note=CTLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00058
GID8	Q9NWU2	105	171	116	212	Region	Note=Interaction with CTNNB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28829046;Dbxref=PMID:28829046
GBF1	Q92538	54	98	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	463	496	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	624	671	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	880	958	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	1591	1625	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	1625	1663	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	1723	1766	1	1859	Chain	ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
GBF1	Q92538	880	958	692	882	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
GBF1	Q92538	54	98	1	380	Region	Note=Interaction with RAB1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17429068;Dbxref=PMID:17429068
GBF1	Q92538	54	98	1	211	Region	Note=DCB%3B DCB:DCB domain and DCB:HUS domain interaction;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1D7
GBF1	Q92538	880	958	886	1370	Region	Note=Phosphatidylinositol-phosphate binding%3B required for translocation to the leading edge and for ARF1 activation upon GPCR signaling;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22573891;Dbxref=PMID:22573891
GBF1	Q92538	1723	1766	1751	1854	Compositional bias	Note=Pro-rich
GBF1	Q92538	624	671	662	662	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
AMT	P48728	292	344	29	403	Chain	ID=PRO_0000010755;Note=Aminomethyltransferase%2C mitochondrial
AMT	P48728	113	157	29	403	Chain	ID=PRO_0000010755;Note=Aminomethyltransferase%2C mitochondrial
AMT	P48728	86	113	29	403	Chain	ID=PRO_0000010755;Note=Aminomethyltransferase%2C mitochondrial
AMT	P48728	30	86	29	403	Chain	ID=PRO_0000010755;Note=Aminomethyltransferase%2C mitochondrial
AMT	P48728	30	86	30	85	Alternative sequence	ID=VSP_042557;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AMT	P48728	113	157	113	156	Alternative sequence	ID=VSP_043288;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AMT	P48728	86	113	113	156	Alternative sequence	ID=VSP_043288;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AMT	P48728	30	86	42	42	Natural variant	ID=VAR_007951;Note=In NKH. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600239;Dbxref=dbSNP:rs121964983,PMID:9600239
AMT	P48728	30	86	47	47	Natural variant	ID=VAR_007952;Note=In NKH. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8005589;Dbxref=dbSNP:rs121964982,PMID:8005589
AMT	P48728	86	113	94	94	Natural variant	ID=VAR_078794;Note=In NKH. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs1126422,PMID:28244183
AMT	P48728	113	157	145	145	Natural variant	ID=VAR_016847;Note=In NKH%3B loss of aminomethyltransferase activity. N->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11286506,ECO:0000269|PubMed:16051266;Dbxref=dbSNP:rs386833682,PMID:11286506,PMID:16051266
AMT	P48728	292	344	296	296	Natural variant	ID=VAR_078796;Note=In NKH. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs1056820947,PMID:28244183
AMT	P48728	292	344	320	320	Natural variant	ID=VAR_007955;Note=In NKH%3B loss of aminomethyltransferase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10873393,ECO:0000269|PubMed:11286506,ECO:0000269|PubMed:16051266,ECO:0000269|PubMed:8005589;Dbxref=dbSNP:rs121964985,PMID:10873393,PMID:11286506,PMID:16051266,PMID:8005589
AMT	P48728	113	157	129	129	Mutagenesis	Note=Loss of aminomethyltransferase activity. D->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16051266;Dbxref=PMID:16051266
AMT	P48728	86	113	95	95	Sequence conflict	Note=V->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMT	P48728	30	86	39	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	30	86	48	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	30	86	55	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	30	86	65	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	30	86	75	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	86	113	84	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	30	86	84	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	86	113	94	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	86	113	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	113	157	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	86	113	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	113	157	126	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	113	157	138	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	113	157	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	113	157	149	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	292	344	294	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	292	344	305	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	292	344	319	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	292	344	335	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
AMT	P48728	292	344	343	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WSR
SERPINE2	P07093	358	386	20	398	Chain	ID=PRO_0000032504;Note=Glia-derived nexin
SERPINE2	P07093	328	358	20	398	Chain	ID=PRO_0000032504;Note=Glia-derived nexin
SERPINE2	P07093	162	228	20	398	Chain	ID=PRO_0000032504;Note=Glia-derived nexin
SERPINE2	P07093	86	162	20	398	Chain	ID=PRO_0000032504;Note=Glia-derived nexin
SERPINE2	P07093	358	386	365	366	Site	Note=Reactive bond;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERPINE2	P07093	86	162	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERPINE2	P07093	86	162	159	159	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERPINE2	P07093	328	358	329	330	Alternative sequence	ID=VSP_038367;Note=In isoform 2 and isoform 3. TG->R;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3427015;Dbxref=PMID:14702039,PMID:15489334,PMID:3427015
SERPINE2	P07093	162	228	204	204	Natural variant	ID=VAR_036027;Note=In a breast cancer sample%3B somatic mutation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SERPINE2	P07093	86	162	159	159	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINE2	P07093	86	162	86	88	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	89	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	109	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	124	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	136	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	146	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	86	162	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	181	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	199	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	203	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	162	228	210	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY7
SERPINE2	P07093	162	228	214	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	328	358	328	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY7
SERPINE2	P07093	328	358	338	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	328	358	354	356	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY7
SERPINE2	P07093	358	386	357	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY7
SERPINE2	P07093	328	358	357	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY7
SERPINE2	P07093	358	386	370	372	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	358	386	377	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
SERPINE2	P07093	358	386	384	387	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DY0
GDPD4	Q6W3E5	69	102	1	623	Chain	ID=PRO_0000251938;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 4
GDPD4	Q6W3E5	69	102	61	69	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD4	Q6W3E5	69	102	70	90	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD4	Q6W3E5	69	102	91	109	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GEMIN2	O14893	115	135	1	280	Chain	ID=PRO_0000087455;Note=Gem-associated protein 2
GEMIN2	O14893	135	173	1	280	Chain	ID=PRO_0000087455;Note=Gem-associated protein 2
GEMIN2	O14893	173	188	1	280	Chain	ID=PRO_0000087455;Note=Gem-associated protein 2
GEMIN2	O14893	188	211	1	280	Chain	ID=PRO_0000087455;Note=Gem-associated protein 2
GEMIN2	O14893	135	173	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN2	O14893	115	135	45	280	Alternative sequence	ID=VSP_013544;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11943600;Dbxref=PMID:11943600
GEMIN2	O14893	135	173	45	280	Alternative sequence	ID=VSP_013544;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11943600;Dbxref=PMID:11943600
GEMIN2	O14893	173	188	45	280	Alternative sequence	ID=VSP_013544;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11943600;Dbxref=PMID:11943600
GEMIN2	O14893	188	211	45	280	Alternative sequence	ID=VSP_013544;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11943600;Dbxref=PMID:11943600
GEMIN2	O14893	135	173	173	187	Alternative sequence	ID=VSP_013545;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11943600;Dbxref=PMID:11943600
GEMIN2	O14893	173	188	173	187	Alternative sequence	ID=VSP_013545;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11943600;Dbxref=PMID:11943600
GEMIN2	O14893	115	135	100	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
GEMIN2	O14893	135	173	141	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
GEMIN2	O14893	135	173	152	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LEH
GEMIN2	O14893	135	173	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LEH
GEMIN2	O14893	135	173	161	164	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LEH
GEMIN2	O14893	135	173	172	174	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LEH
GEMIN2	O14893	173	188	172	174	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LEH
GEMIN2	O14893	173	188	180	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
GEMIN2	O14893	173	188	188	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
GEMIN2	O14893	188	211	188	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
GEMIN2	O14893	188	211	209	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
GKN2	Q86XP6	22	68	21	184	Chain	ID=PRO_0000252104;Note=Gastrokine-2
GKN2	Q86XP6	22	68	54	151	Domain	Note=BRICHOS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00255
GKN2	Q86XP6	22	68	51	51	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLCCI1	Q86VQ1	232	271	1	547	Chain	ID=PRO_0000256128;Note=Glucocorticoid-induced transcript 1 protein
GLCCI1	Q86VQ1	271	322	1	547	Chain	ID=PRO_0000256128;Note=Glucocorticoid-induced transcript 1 protein
GLCCI1	Q86VQ1	232	271	225	254	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GLCCI1	Q86VQ1	232	271	258	258	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
GLCCI1	Q86VQ1	232	271	266	266	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GLCCI1	Q86VQ1	271	322	303	303	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:23186163
GLE1	Q53GS7	107	144	1	698	Chain	ID=PRO_0000204822;Note=Nucleoporin GLE1
GLE1	Q53GS7	592	627	1	698	Chain	ID=PRO_0000204822;Note=Nucleoporin GLE1
GLE1	Q53GS7	107	144	130	130	Natural variant	ID=VAR_024056;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852725,PMID:15489334
GLE1	Q53GS7	107	144	144	144	Natural variant	ID=VAR_043874;Note=In LCCS1%3B allele Fin(Major)%3B does not affect subcellular localization. T->TPFQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18204449;Dbxref=PMID:18204449
GLE1	Q53GS7	592	627	617	617	Natural variant	ID=VAR_043876;Note=In LAAHD. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18204449;Dbxref=dbSNP:rs121434408,PMID:18204449
GLE1	Q53GS7	592	627	599	609	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B4F
GLE1	Q53GS7	592	627	617	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B4F
GGT6	Q6P531	114	146	76	493	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT6	Q6P531	114	146	116	147	Alternative sequence	ID=VSP_030451;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLI3	P10071	604	701	1	1580	Chain	ID=PRO_0000047202;Note=Transcriptional activator GLI3
GLI3	P10071	41	122	1	1580	Chain	ID=PRO_0000047202;Note=Transcriptional activator GLI3
GLI3	P10071	604	701	607	632	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
GLI3	P10071	604	701	664	664	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
GLI3	P10071	604	701	625	625	Natural variant	ID=VAR_021481;Note=In GCPS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12794692;Dbxref=dbSNP:rs121917712,PMID:12794692
GOLPH3L	Q9H4A5	61	105	1	285	Chain	ID=PRO_0000324135;Note=Golgi phosphoprotein 3-like
GOLPH3L	Q9H4A5	61	105	67	67	Binding site	Note=PtdIns4P;Ontology_term=ECO:0000250;evidence=ECO:0000250
GOLPH3L	Q9H4A5	61	105	76	76	Binding site	Note=PtdIns4P;Ontology_term=ECO:0000250;evidence=ECO:0000250
GOLPH3L	Q9H4A5	61	105	62	105	Alternative sequence	ID=VSP_055229;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GYPB	P06028	12	45	1	19	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:3571235,ECO:0000269|PubMed:3595615,ECO:0000269|PubMed:7681597;Dbxref=PMID:3571235,PMID:3595615,PMID:7681597
GYPB	P06028	12	45	20	91	Chain	ID=PRO_0000012136;Note=Glycophorin-B
GYPB	P06028	12	45	20	59	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GYPB	P06028	12	45	33	33	Site	Note=Not glycosylated
GYPB	P06028	12	45	34	34	Site	Note=Not glycosylated
GYPB	P06028	12	45	36	36	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7681597;Dbxref=PMID:7681597
GYPB	P06028	12	45	38	38	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7681597;Dbxref=PMID:7681597
GYPB	P06028	12	45	13	45	Alternative sequence	ID=VSP_047824;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GYPB	P06028	12	45	22	22	Natural variant	ID=VAR_047948;Note=In M(v) antigen. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11239234;Dbxref=dbSNP:rs199937833,PMID:11239234
GLRA3	O75311	357	372	34	464	Chain	ID=PRO_0000000419;Note=Glycine receptor subunit alpha-3
GLRA3	O75311	357	372	336	430	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26416729;Dbxref=PMID:26416729
GLRA3	O75311	357	372	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91XP5
GLRA3	O75311	357	372	358	372	Alternative sequence	ID=VSP_000084;Note=In isoform Alpha-3K. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9677400;Dbxref=PMID:9677400
GALNT12	Q8IXK2	244	305	1	581	Chain	ID=PRO_0000059128;Note=Polypeptide N-acetylgalactosaminyltransferase 12
GALNT12	Q8IXK2	345	404	1	581	Chain	ID=PRO_0000059128;Note=Polypeptide N-acetylgalactosaminyltransferase 12
GALNT12	Q8IXK2	486	535	1	581	Chain	ID=PRO_0000059128;Note=Polypeptide N-acetylgalactosaminyltransferase 12
GALNT12	Q8IXK2	244	305	38	581	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT12	Q8IXK2	345	404	38	581	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT12	Q8IXK2	486	535	38	581	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT12	Q8IXK2	486	535	445	577	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT12	Q8IXK2	244	305	135	244	Region	Note=Catalytic subdomain A
GALNT12	Q8IXK2	244	305	304	366	Region	Note=Catalytic subdomain B
GALNT12	Q8IXK2	345	404	304	366	Region	Note=Catalytic subdomain B
GALNT12	Q8IXK2	345	404	363	363	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT12	Q8IXK2	345	404	371	371	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT12	Q8IXK2	244	305	125	358	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT12	Q8IXK2	345	404	125	358	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT12	Q8IXK2	345	404	349	422	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT12	Q8IXK2	486	535	506	521	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT12	Q8IXK2	244	305	1	309	Alternative sequence	ID=VSP_011217;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT12	Q8IXK2	244	305	261	261	Natural variant	ID=VAR_064355;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19617566;Dbxref=dbSNP:rs41306504,PMID:19617566
GALNT12	Q8IXK2	244	305	272	272	Natural variant	ID=VAR_064356;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19617566;Dbxref=dbSNP:rs367645298,PMID:19617566
GALNT12	Q8IXK2	244	305	297	297	Natural variant	ID=VAR_064357;Note=In CRCS1%3B germline mutation%3B partial loss of activity. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19617566;Dbxref=dbSNP:rs149726976,PMID:19617566
GALNT12	Q8IXK2	244	305	303	303	Natural variant	ID=VAR_064358;Note=In CRCS1%3B germline mutation%3B reduction of activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19617566,ECO:0000269|PubMed:22461326;Dbxref=dbSNP:rs145236923,PMID:19617566,PMID:22461326
GALNT12	Q8IXK2	345	404	373	373	Natural variant	ID=VAR_064360;Note=In CRCS1%3B germline mutation%3B partial loss of activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19617566;Dbxref=dbSNP:rs920049418,PMID:19617566
GALNT12	Q8IXK2	345	404	382	382	Natural variant	ID=VAR_064361;Note=In CRCS1%3B germline mutation%3B loss of activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19617566;Dbxref=dbSNP:rs868590153,PMID:19617566
GALNT12	Q8IXK2	345	404	396	396	Natural variant	ID=VAR_068509;Note=In CRCS1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22461326;Dbxref=PMID:22461326
GALNT12	Q8IXK2	486	535	491	491	Natural variant	ID=VAR_064363;Note=In CRCS1%3B germline mutation%3B loss of activity. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19617566;Dbxref=dbSNP:rs267606840,PMID:19617566
PRKCSH	P14314	254	283	15	528	Chain	ID=PRO_0000004143;Note=Glucosidase 2 subunit beta
PRKCSH	P14314	392	421	15	528	Chain	ID=PRO_0000004143;Note=Glucosidase 2 subunit beta
PRKCSH	P14314	422	446	15	528	Chain	ID=PRO_0000004143;Note=Glucosidase 2 subunit beta
PRKCSH	P14314	254	283	245	290	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PRKCSH	P14314	392	421	413	468	Domain	Note=PRKCSH
PRKCSH	P14314	422	446	413	468	Domain	Note=PRKCSH
PRKCSH	P14314	422	446	434	434	Modified residue	Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000255;evidence=ECO:0000255
PRKCSH	P14314	254	283	18	528	Natural variant	ID=VAR_080939;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	392	421	18	528	Natural variant	ID=VAR_080939;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	422	446	18	528	Natural variant	ID=VAR_080939;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	254	283	156	528	Natural variant	ID=VAR_080940;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	392	421	156	528	Natural variant	ID=VAR_080940;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	422	446	156	528	Natural variant	ID=VAR_080940;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	254	283	198	528	Natural variant	ID=VAR_080941;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	392	421	198	528	Natural variant	ID=VAR_080941;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	422	446	198	528	Natural variant	ID=VAR_080941;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	392	421	414	528	Natural variant	ID=VAR_080942;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	422	446	414	528	Natural variant	ID=VAR_080942;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PRKCSH	P14314	422	446	423	528	Natural variant	ID=VAR_080943;Note=In PCLD1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
GNL3L	Q9NVN8	102	130	1	582	Chain	ID=PRO_0000284381;Note=Guanine nucleotide-binding protein-like 3-like protein
GNL3L	Q9NVN8	102	130	1	582	Chain	ID=PRO_0000284381;Note=Guanine nucleotide-binding protein-like 3-like protein
GNL3L	Q9NVN8	102	130	125	310	Domain	Note=CP-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01058
GNL3L	Q9NVN8	102	130	125	310	Domain	Note=CP-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01058
GNAQ	P50148	159	201	1	359	Chain	ID=PRO_0000203760;Note=Guanine nucleotide-binding protein G(q) subunit alpha
GNAQ	P50148	159	201	180	186	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNAQ	P50148	159	201	186	186	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNAQ	P50148	159	201	183	183	Modified residue	Note=ADP-ribosylarginine%3B by cholera toxin;Ontology_term=ECO:0000250;evidence=ECO:0000250
GNAQ	P50148	159	201	183	183	Natural variant	ID=VAR_067270;Note=In SWS%3B found as somatic mosaic mutation in CMC%3B also found in melanocytomas sample%3B somatic mutation%3B shows significant activation of EPHB2 compared to control. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22307269,ECO:0000269|PubMed:23656586;Dbxref=dbSNP:rs397514698,PMID:22307269,PMID:23656586
GGA2	Q9UJY4	540	577	1	613	Chain	ID=PRO_0000212682;Note=ADP-ribosylation factor-binding protein GGA2
GGA2	Q9UJY4	293	335	1	613	Chain	ID=PRO_0000212682;Note=ADP-ribosylation factor-binding protein GGA2
GGA2	Q9UJY4	193	220	1	613	Chain	ID=PRO_0000212682;Note=ADP-ribosylation factor-binding protein GGA2
GGA2	Q9UJY4	84	117	1	613	Chain	ID=PRO_0000212682;Note=ADP-ribosylation factor-binding protein GGA2
GGA2	Q9UJY4	84	117	33	163	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
GGA2	Q9UJY4	293	335	188	315	Domain	Note=GAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00373
GGA2	Q9UJY4	193	220	188	315	Domain	Note=GAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00373
GGA2	Q9UJY4	540	577	484	605	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
GGA2	Q9UJY4	293	335	316	483	Region	Note=Unstructured hinge
GGA2	Q9UJY4	84	117	76	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MHQ
GGA2	Q9UJY4	84	117	95	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MHQ
GGA2	Q9UJY4	84	117	104	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MHQ
GLDN	Q6ZMI3	229	272	1	551	Chain	ID=PRO_0000246321;Note=Gliomedin
GLDN	Q6ZMI3	229	272	95	454	Chain	ID=PRO_0000434265;Note=Gliomedin shedded ectodomain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMF8
GLDN	Q6ZMI3	229	272	40	551	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GLDN	Q6ZMI3	229	272	237	264	Compositional bias	Note=Pro-rich
GLDN	Q6ZMI3	229	272	265	265	Natural variant	ID=VAR_050424;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs17648128,PMID:12975309
GLUL	P15104	109	158	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	55	109	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	109	158	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	55	109	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	109	158	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	55	109	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	109	158	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	55	109	2	373	Chain	ID=PRO_0000153139;Note=Glutamine synthetase
GLUL	P15104	55	109	104	104	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15105
GLUL	P15104	55	109	104	104	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15105
GLUL	P15104	55	109	104	104	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15105
GLUL	P15104	55	109	104	104	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15105
GLUL	P15104	109	158	154	154	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	154	154	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	154	154	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	154	154	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	155	155	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	155	155	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	155	155	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	109	158	155	155	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLUL	P15104	55	109	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	60	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	60	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	60	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	60	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	64	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	64	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	64	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	64	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	72	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	72	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	72	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	72	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	76	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	76	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	76	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	76	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	95	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	95	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	95	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	95	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	55	109	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	55	109	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	109	158	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	124	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	124	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	124	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	124	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	130	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	130	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	130	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	130	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	109	158	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	109	158	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	109	158	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QC8
GLUL	P15104	109	158	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLUL	P15104	109	158	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OJW
GLRA4	Q5JXX5	192	239	29	417	Chain	ID=PRO_0000338609;Note=Glycine receptor subunit alpha-4
GLRA4	Q5JXX5	192	239	29	257	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P23415
GLRA4	Q5JXX5	192	239	237	242	Region	Note=Strychnine-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O93430
GLRA4	Q5JXX5	192	239	233	244	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P23415
GALNT15	Q8N3T1	399	464	1	639	Chain	ID=PRO_0000059137;Note=Polypeptide N-acetylgalactosaminyltransferase 15
GALNT15	Q8N3T1	399	464	35	639	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT15	Q8N3T1	399	464	358	420	Region	Note=Catalytic subdomain B
GALNT15	Q8N3T1	399	464	417	417	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT15	Q8N3T1	399	464	181	412	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT15	Q8N3T1	399	464	403	482	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT15	Q8N3T1	399	464	432	432	Natural variant	ID=VAR_049246;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17974005,ECO:0000269|Ref.7;Dbxref=dbSNP:rs17851238,PMID:17974005
GLMN	Q92990	366	380	2	594	Chain	ID=PRO_0000087513;Note=Glomulin
GLMN	Q92990	336	366	2	594	Chain	ID=PRO_0000087513;Note=Glomulin
GLMN	Q92990	55	95	2	594	Chain	ID=PRO_0000087513;Note=Glomulin
GLMN	Q92990	13	55	2	594	Chain	ID=PRO_0000087513;Note=Glomulin
GLMN	Q92990	366	380	2	553	Region	Note=Alpha-helical region with structural similarity to HEAT repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22748924;Dbxref=PMID:22748924
GLMN	Q92990	336	366	2	553	Region	Note=Alpha-helical region with structural similarity to HEAT repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22748924;Dbxref=PMID:22748924
GLMN	Q92990	55	95	2	553	Region	Note=Alpha-helical region with structural similarity to HEAT repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22748924;Dbxref=PMID:22748924
GLMN	Q92990	13	55	2	553	Region	Note=Alpha-helical region with structural similarity to HEAT repeats;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22748924;Dbxref=PMID:22748924
GLMN	Q92990	366	380	300	594	Region	Note=Important for interaction with RBX1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22748924;Dbxref=PMID:22748924
GLMN	Q92990	336	366	300	594	Region	Note=Important for interaction with RBX1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22748924;Dbxref=PMID:22748924
GLMN	Q92990	336	366	336	336	Natural variant	ID=VAR_061653;Note=L->S;Dbxref=dbSNP:rs35258161
GLMN	Q92990	13	55	2	13	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	13	55	28	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	13	55	38	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	13	55	43	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	55	95	55	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	13	55	55	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	55	95	62	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	55	95	66	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	55	95	80	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	55	95	84	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	336	366	329	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	336	366	353	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	366	380	359	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	336	366	359	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLMN	Q92990	366	380	378	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F52
GLOD4	Q9HC38	225	263	1	313	Chain	ID=PRO_0000280391;Note=Glyoxalase domain-containing protein 4
GLOD4	Q9HC38	196	225	1	313	Chain	ID=PRO_0000280391;Note=Glyoxalase domain-containing protein 4
GLOD4	Q9HC38	225	263	152	273	Domain	Note=VOC 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01163
GLOD4	Q9HC38	196	225	152	273	Domain	Note=VOC 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01163
GLOD4	Q9HC38	196	225	197	203	Alternative sequence	ID=VSP_023647;Note=In isoform 3. CKLELQG->VSNLGEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLOD4	Q9HC38	225	263	204	313	Alternative sequence	ID=VSP_023648;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLOD4	Q9HC38	196	225	204	313	Alternative sequence	ID=VSP_023648;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLOD4	Q9HC38	196	225	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GLOD4	Q9HC38	196	225	216	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GLOD4	Q9HC38	225	263	223	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GLOD4	Q9HC38	196	225	223	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GLOD4	Q9HC38	225	263	226	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GLOD4	Q9HC38	225	263	239	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GLOD4	Q9HC38	225	263	255	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZI1
GK	P32189	86	112	1	559	Chain	ID=PRO_0000059535;Note=Glycerol kinase
GK	P32189	138	184	1	559	Chain	ID=PRO_0000059535;Note=Glycerol kinase
GK	P32189	243	255	1	559	Chain	ID=PRO_0000059535;Note=Glycerol kinase
GK	P32189	494	521	1	559	Chain	ID=PRO_0000059535;Note=Glycerol kinase
GK	P32189	86	112	94	94	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GK	P32189	138	184	148	148	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GK	P32189	243	255	245	250	Alternative sequence	ID=VSP_000770;Note=In isoform 1 and isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7987308,ECO:0000303|PubMed:8401584,ECO:0000303|PubMed:8499898;Dbxref=PMID:14702039,PMID:15489334,PMID:7987308,PMID:8401584,PMID:8499898
GK	P32189	494	521	509	509	Natural variant	ID=VAR_010138;Note=In GKD. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9719371;Dbxref=dbSNP:rs132630330,PMID:9719371
GLS	O94925	399	416	17	669	Chain	ID=PRO_0000011622;Note=Glutaminase kidney isoform%2C mitochondrial
GLS	O94925	416	475	17	669	Chain	ID=PRO_0000011622;Note=Glutaminase kidney isoform%2C mitochondrial
GLS	O94925	519	550	17	669	Chain	ID=PRO_0000011622;Note=Glutaminase kidney isoform%2C mitochondrial
GLS	O94925	399	416	414	414	Binding site	Note=Substrate
GLS	O94925	416	475	466	466	Binding site	Note=Substrate
GLS	O94925	399	416	170	669	Alternative sequence	ID=VSP_001766;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLS	O94925	416	475	170	669	Alternative sequence	ID=VSP_001766;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLS	O94925	519	550	170	669	Alternative sequence	ID=VSP_001766;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLS	O94925	399	416	407	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	407	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	420	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	424	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	436	438	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	441	443	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	450	463	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	466	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	416	475	469	475	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS	O94925	519	550	512	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JYO
GLS2	Q9UI32	349	408	15	602	Chain	ID=PRO_0000011625;Note=Glutaminase liver isoform%2C mitochondrial
GLS2	Q9UI32	332	349	15	602	Chain	ID=PRO_0000011625;Note=Glutaminase liver isoform%2C mitochondrial
GLS2	Q9UI32	279	290	15	602	Chain	ID=PRO_0000011625;Note=Glutaminase liver isoform%2C mitochondrial
GLS2	Q9UI32	332	349	347	347	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLS2	Q9UI32	349	408	399	399	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLS2	Q9UI32	279	290	279	279	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q571F8
GLS2	Q9UI32	279	290	284	284	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q571F8
GLS2	Q9UI32	349	408	210	602	Alternative sequence	ID=VSP_057010;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLS2	Q9UI32	332	349	210	602	Alternative sequence	ID=VSP_057010;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLS2	Q9UI32	279	290	210	602	Alternative sequence	ID=VSP_057010;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLS2	Q9UI32	279	290	278	281	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	279	290	284	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	340	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	332	349	340	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	353	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	357	368	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	369	371	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	374	376	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	383	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	399	401	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GLS2	Q9UI32	349	408	402	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BQM
GALNT13	Q8IUC8	432	465	1	556	Chain	ID=PRO_0000059130;Note=Polypeptide N-acetylgalactosaminyltransferase 13
GALNT13	Q8IUC8	465	510	1	556	Chain	ID=PRO_0000059130;Note=Polypeptide N-acetylgalactosaminyltransferase 13
GALNT13	Q8IUC8	432	465	28	556	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT13	Q8IUC8	465	510	28	556	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT13	Q8IUC8	432	465	428	550	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT13	Q8IUC8	465	510	428	550	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT13	Q8IUC8	432	465	441	458	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT13	Q8IUC8	465	510	481	496	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT13	Q8IUC8	465	510	466	486	Alternative sequence	ID=VSP_011218;Note=In isoform 2. VFSYTADKEIRTDDLCLDVSR->TQWTCNHVKMPPYERKSVMGI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GALNT13	Q8IUC8	465	510	487	556	Alternative sequence	ID=VSP_011219;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GALNTL6	Q49A17	496	546	1	601	Chain	ID=PRO_0000325774;Note=Polypeptide N-acetylgalactosaminyltransferase-like 6
GALNTL6	Q49A17	496	546	29	601	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNTL6	Q49A17	496	546	453	585	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNTL6	Q49A17	496	546	518	533	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
SLC2A4	P14672	340	374	1	509	Chain	ID=PRO_0000050363;Note=Solute carrier family 2%2C facilitated glucose transporter member 4
SLC2A4	P14672	340	374	324	344	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A4	P14672	340	374	345	353	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A4	P14672	340	374	354	374	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A4	P14672	340	374	342	415	Alternative sequence	ID=VSP_056331;Note=In isoform 2. LLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGP->TAHLWNGPSHWLHLPGCPGGVVGGAGGAPDAPSPGPGGHVWLCHPDDCGSAPAGASSSHELRLHCGHLWLRGIF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC2A4	P14672	340	374	358	358	Natural variant	ID=VAR_020336;Note=A->V;Dbxref=dbSNP:rs8192702
GCDH	Q92947	30	42	1	44	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
GCDH	Q92947	42	90	1	44	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
GCDH	Q92947	30	42	1	44	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
GCDH	Q92947	42	90	1	44	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
GCDH	Q92947	42	90	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	90	111	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	111	168	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	319	360	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	42	90	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	90	111	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	111	168	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	319	360	45	438	Chain	ID=PRO_0000000526;Note=Glutaryl-CoA dehydrogenase%2C mitochondrial
GCDH	Q92947	111	168	138	139	Region	Note=Substrate binding
GCDH	Q92947	111	168	138	139	Region	Note=Substrate binding
GCDH	Q92947	319	360	319	319	Binding site	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GCDH	Q92947	319	360	319	319	Binding site	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GCDH	Q92947	319	360	330	330	Binding site	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GCDH	Q92947	319	360	330	330	Binding site	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GCDH	Q92947	42	90	64	64	Natural variant	ID=VAR_071510;Note=In GA1. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24973495;Dbxref=PMID:24973495
GCDH	Q92947	42	90	64	64	Natural variant	ID=VAR_071510;Note=In GA1. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24973495;Dbxref=PMID:24973495
GCDH	Q92947	42	90	88	88	Natural variant	ID=VAR_000366;Note=In GA1. R->C;Dbxref=dbSNP:rs142967670
GCDH	Q92947	42	90	88	88	Natural variant	ID=VAR_000366;Note=In GA1. R->C;Dbxref=dbSNP:rs142967670
GCDH	Q92947	90	111	94	94	Natural variant	ID=VAR_000367;Note=In GA1. R->L
GCDH	Q92947	90	111	94	94	Natural variant	ID=VAR_000367;Note=In GA1. R->L
GCDH	Q92947	90	111	101	101	Natural variant	ID=VAR_000368;Note=In GA1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8900228;Dbxref=dbSNP:rs1273164833,PMID:8900228
GCDH	Q92947	90	111	101	101	Natural variant	ID=VAR_000368;Note=In GA1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8900228;Dbxref=dbSNP:rs1273164833,PMID:8900228
GCDH	Q92947	111	168	115	115	Natural variant	ID=VAR_000369;Note=In GA1. C->Y;Dbxref=dbSNP:rs776758971
GCDH	Q92947	111	168	115	115	Natural variant	ID=VAR_000369;Note=In GA1. C->Y;Dbxref=dbSNP:rs776758971
GCDH	Q92947	111	168	122	122	Natural variant	ID=VAR_000370;Note=In GA1. A->V;Dbxref=dbSNP:rs766325846
GCDH	Q92947	111	168	122	122	Natural variant	ID=VAR_000370;Note=In GA1. A->V;Dbxref=dbSNP:rs766325846
GCDH	Q92947	111	168	128	128	Natural variant	ID=VAR_000371;Note=In GA1. R->G
GCDH	Q92947	111	168	128	128	Natural variant	ID=VAR_000371;Note=In GA1. R->G
GCDH	Q92947	111	168	138	138	Natural variant	ID=VAR_000372;Note=In GA1%3B impaired protein stability%3B loss of activity. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18775954;Dbxref=dbSNP:rs897036690,PMID:18775954
GCDH	Q92947	111	168	138	138	Natural variant	ID=VAR_000372;Note=In GA1%3B impaired protein stability%3B loss of activity. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18775954;Dbxref=dbSNP:rs897036690,PMID:18775954
GCDH	Q92947	111	168	139	139	Natural variant	ID=VAR_000373;Note=In GA1. S->L;Dbxref=dbSNP:rs139851890
GCDH	Q92947	111	168	139	139	Natural variant	ID=VAR_000373;Note=In GA1. S->L;Dbxref=dbSNP:rs139851890
GCDH	Q92947	111	168	148	148	Natural variant	ID=VAR_000374;Note=In GA1. V->I
GCDH	Q92947	111	168	148	148	Natural variant	ID=VAR_000374;Note=In GA1. V->I
GCDH	Q92947	111	168	161	161	Natural variant	ID=VAR_000375;Note=In GA1. R->Q;Dbxref=dbSNP:rs777201305
GCDH	Q92947	111	168	161	161	Natural variant	ID=VAR_000375;Note=In GA1. R->Q;Dbxref=dbSNP:rs777201305
GCDH	Q92947	319	360	333	333	Natural variant	ID=VAR_000396;Note=In GA1. Q->E;Dbxref=dbSNP:rs794726972
GCDH	Q92947	319	360	333	333	Natural variant	ID=VAR_000396;Note=In GA1. Q->E;Dbxref=dbSNP:rs794726972
GCDH	Q92947	319	360	349	349	Natural variant	ID=VAR_000397;Note=In GA1. A->T;Dbxref=dbSNP:rs1257292639
GCDH	Q92947	319	360	349	349	Natural variant	ID=VAR_000397;Note=In GA1. A->T;Dbxref=dbSNP:rs1257292639
GCDH	Q92947	319	360	354	354	Natural variant	ID=VAR_000398;Note=In GA1. G->R
GCDH	Q92947	319	360	354	354	Natural variant	ID=VAR_000398;Note=In GA1. G->R
GCDH	Q92947	319	360	354	354	Natural variant	ID=VAR_000399;Note=In GA1. G->S;Dbxref=dbSNP:rs768925619
GCDH	Q92947	319	360	354	354	Natural variant	ID=VAR_000399;Note=In GA1. G->S;Dbxref=dbSNP:rs768925619
GCDH	Q92947	319	360	355	355	Natural variant	ID=VAR_000400;Note=In GA1. R->C;Dbxref=dbSNP:rs781477694
GCDH	Q92947	319	360	355	355	Natural variant	ID=VAR_000400;Note=In GA1. R->C;Dbxref=dbSNP:rs781477694
GCDH	Q92947	319	360	355	355	Natural variant	ID=VAR_000401;Note=In GA1. R->H;Dbxref=dbSNP:rs748275416
GCDH	Q92947	319	360	355	355	Natural variant	ID=VAR_000401;Note=In GA1. R->H;Dbxref=dbSNP:rs748275416
GCDH	Q92947	30	42	33	33	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
GCDH	Q92947	30	42	33	33	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
GCDH	Q92947	42	90	56	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	42	90	56	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	42	90	62	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	42	90	62	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	42	90	80	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	42	90	80	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	90	111	95	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	90	111	95	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	120	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	120	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	135	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	135	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	149	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	149	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	158	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	111	168	158	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	319	360	326	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	319	360	326	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	319	360	330	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCDH	Q92947	319	360	330	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SIQ
GCFC2	P16383	652	701	1	781	Chain	ID=PRO_0000087441;Note=GC-rich sequence DNA-binding factor 2
GCFC2	P16383	131	206	1	781	Chain	ID=PRO_0000087441;Note=GC-rich sequence DNA-binding factor 2
GCFC2	P16383	131	206	174	174	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GCFC2	P16383	131	206	180	180	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GCFC2	P16383	131	206	169	207	Alternative sequence	ID=VSP_021798;Note=In isoform 2. GMKRESEDDPESEPDDHEKRIPFTLRPQTLRQRMAEESI->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2556218;Dbxref=PMID:2556218
GCFC2	P16383	652	701	214	779	Alternative sequence	ID=VSP_054363;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17309879;Dbxref=PMID:17309879
GCFC2	P16383	652	701	255	781	Alternative sequence	ID=VSP_057399;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17309879;Dbxref=PMID:17309879
HHIPL1	Q96JK4	301	348	20	782	Chain	ID=PRO_0000314962;Note=HHIP-like protein 1
HHIPL1	Q96JK4	301	348	181	521	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
HHIPL1	Q96JK4	301	348	185	528	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
ARHGDIG	Q99819	24	84	1	225	Chain	ID=PRO_0000219018;Note=Rho GDP-dissociation inhibitor 3
GFPT2	O94808	614	668	2	682	Chain	ID=PRO_0000135283;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
GFPT2	O94808	558	614	2	682	Chain	ID=PRO_0000135283;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
GFPT2	O94808	614	668	531	672	Domain	Note=SIS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00797
GFPT2	O94808	558	614	531	672	Domain	Note=SIS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00797
GFPT2	O94808	558	614	578	578	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q06210
GGT1	P19440	98	127	1	380	Chain	ID=PRO_0000011058;Note=Glutathione hydrolase 1 heavy chain
GGT1	P19440	98	127	1	380	Chain	ID=PRO_0000011058;Note=Glutathione hydrolase 1 heavy chain
GGT1	P19440	98	127	1	380	Chain	ID=PRO_0000011058;Note=Glutathione hydrolase 1 heavy chain
GGT1	P19440	483	521	381	569	Chain	ID=PRO_0000011059;Note=Glutathione hydrolase 1 light chain
GGT1	P19440	483	521	381	569	Chain	ID=PRO_0000011059;Note=Glutathione hydrolase 1 light chain
GGT1	P19440	483	521	381	569	Chain	ID=PRO_0000011059;Note=Glutathione hydrolase 1 light chain
GGT1	P19440	98	127	27	569	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT1	P19440	483	521	27	569	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT1	P19440	98	127	27	569	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT1	P19440	483	521	27	569	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT1	P19440	98	127	27	569	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT1	P19440	483	521	27	569	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GGT1	P19440	98	127	107	107	Binding site	Note=Glutamate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24047895;Dbxref=PMID:24047895
GGT1	P19440	98	127	107	107	Binding site	Note=Glutamate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24047895;Dbxref=PMID:24047895
GGT1	P19440	98	127	107	107	Binding site	Note=Glutamate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24047895;Dbxref=PMID:24047895
GGT1	P19440	98	127	120	120	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17924658,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895;Dbxref=PMID:17924658,PMID:19159218,PMID:19349973,PMID:20622017,PMID:24047895
GGT1	P19440	98	127	120	120	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17924658,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895;Dbxref=PMID:17924658,PMID:19159218,PMID:19349973,PMID:20622017,PMID:24047895
GGT1	P19440	98	127	120	120	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17924658,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895;Dbxref=PMID:17924658,PMID:19159218,PMID:19349973,PMID:20622017,PMID:24047895
GGT1	P19440	483	521	511	511	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:17924658,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895;Dbxref=PMID:15084671,PMID:17924658,PMID:19159218,PMID:20622017,PMID:24047895
GGT1	P19440	483	521	511	511	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:17924658,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895;Dbxref=PMID:15084671,PMID:17924658,PMID:19159218,PMID:20622017,PMID:24047895
GGT1	P19440	483	521	511	511	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:17924658,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895;Dbxref=PMID:15084671,PMID:17924658,PMID:19159218,PMID:20622017,PMID:24047895
GGT1	P19440	98	127	1	344	Alternative sequence	ID=VSP_008132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7689219;Dbxref=PMID:15489334,PMID:7689219
GGT1	P19440	98	127	1	344	Alternative sequence	ID=VSP_008132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7689219;Dbxref=PMID:15489334,PMID:7689219
GGT1	P19440	98	127	1	344	Alternative sequence	ID=VSP_008132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7689219;Dbxref=PMID:15489334,PMID:7689219
GGT1	P19440	483	521	367	569	Alternative sequence	ID=VSP_001747;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1968061;Dbxref=PMID:1968061
GGT1	P19440	483	521	367	569	Alternative sequence	ID=VSP_001747;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1968061;Dbxref=PMID:1968061
GGT1	P19440	483	521	367	569	Alternative sequence	ID=VSP_001747;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1968061;Dbxref=PMID:1968061
GGT1	P19440	98	127	100	100	Mutagenesis	Note=No effect on activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	100	100	Mutagenesis	Note=No effect on activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	100	100	Mutagenesis	Note=No effect on activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	102	102	Mutagenesis	Note=No effect on activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	102	102	Mutagenesis	Note=No effect on activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	102	102	Mutagenesis	Note=No effect on activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	107	107	Mutagenesis	Note=Reduces enzyme activity by 99%25. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	107	107	Mutagenesis	Note=Reduces enzyme activity by 99%25. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	107	107	Mutagenesis	Note=Reduces enzyme activity by 99%25. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	107	107	Mutagenesis	Note=Abolishes enzyme activity. R->Q%2CH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	107	107	Mutagenesis	Note=Abolishes enzyme activity. R->Q%2CH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	107	107	Mutagenesis	Note=Abolishes enzyme activity. R->Q%2CH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	108	108	Mutagenesis	Note=Reduces enzyme activity by 98%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	108	108	Mutagenesis	Note=Reduces enzyme activity by 98%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	108	108	Mutagenesis	Note=Reduces enzyme activity by 98%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	112	112	Mutagenesis	Note=No effect on activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	112	112	Mutagenesis	Note=No effect on activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	98	127	112	112	Mutagenesis	Note=No effect on activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8095045;Dbxref=PMID:8095045
GGT1	P19440	483	521	505	505	Mutagenesis	Note=Reduces enzyme activity by 90%25. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8827453;Dbxref=PMID:8827453
GGT1	P19440	483	521	505	505	Mutagenesis	Note=Reduces enzyme activity by 90%25. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8827453;Dbxref=PMID:8827453
GGT1	P19440	483	521	505	505	Mutagenesis	Note=Reduces enzyme activity by 90%25. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8827453;Dbxref=PMID:8827453
GGT1	P19440	98	127	96	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	96	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	96	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	100	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	100	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	100	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	122	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	122	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	98	127	122	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	477	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	477	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	477	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	495	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	495	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	495	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	508	511	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	508	511	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	508	511	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	513	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	513	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	513	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	521	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	521	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGT1	P19440	483	521	521	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GDX
GGTLC1	Q9BX51	139	177	1	225	Chain	ID=PRO_0000205983;Note=Glutathione hydrolase light chain 1
GGTLC1	Q9BX51	139	177	1	225	Chain	ID=PRO_0000205983;Note=Glutathione hydrolase light chain 1
GGTLC1	Q9BX51	139	177	1	225	Chain	ID=PRO_0000205983;Note=Glutathione hydrolase light chain 1
GHRHR	Q02643	368	382	23	423	Chain	ID=PRO_0000012828;Note=Growth hormone-releasing hormone receptor
GHRHR	Q02643	368	382	362	381	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
GHRHR	Q02643	368	382	382	423	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GIPR	P48546	57	93	22	466	Chain	ID=PRO_0000012825;Note=Gastric inhibitory polypeptide receptor
GIPR	P48546	57	93	22	138	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GIPR	P48546	57	93	62	62	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22412906;Dbxref=PMID:22412906
GIPR	P48546	57	93	77	77	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22412906;Dbxref=PMID:22412906
GIPR	P48546	57	93	46	70	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17715056;Dbxref=PMID:17715056
GIPR	P48546	57	93	61	103	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17715056;Dbxref=PMID:17715056
GIPR	P48546	57	93	84	118	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17715056;Dbxref=PMID:17715056
GIPR	P48546	57	93	58	93	Alternative sequence	ID=VSP_053866;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GIPR	P48546	57	93	67	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HJ0
GIPR	P48546	57	93	78	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKH
GIPR	P48546	57	93	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HJ0
GIPR	P48546	57	93	91	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKH
GID4	Q8IVV7	202	236	1	300	Chain	ID=PRO_0000079302;Note=Glucose-induced degradation protein 4 homolog
GID4	Q8IVV7	202	236	195	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CD9
GID4	Q8IVV7	202	236	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CD9
GID4	Q8IVV7	202	236	211	216	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CCR
GID4	Q8IVV7	202	236	217	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CDC
GID4	Q8IVV7	202	236	222	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CD9
GID4	Q8IVV7	202	236	228	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CD9
GIT2	Q14161	547	577	1	759	Chain	ID=PRO_0000074203;Note=ARF GTPase-activating protein GIT2
GIT2	Q14161	464	547	1	759	Chain	ID=PRO_0000074203;Note=ARF GTPase-activating protein GIT2
GIT2	Q14161	414	464	1	759	Chain	ID=PRO_0000074203;Note=ARF GTPase-activating protein GIT2
GIT2	Q14161	414	464	415	415	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:24275569
GIT2	Q14161	414	464	418	418	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
GIT2	Q14161	414	464	421	421	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231;Dbxref=PMID:17081983,PMID:20068231
GIT2	Q14161	464	547	484	484	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
GIT2	Q14161	547	577	559	559	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
GIT2	Q14161	547	577	562	562	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLQ2
GIT2	Q14161	547	577	570	570	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLQ2
GIT2	Q14161	414	464	334	414	Alternative sequence	ID=VSP_000305;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10896954;Dbxref=PMID:10896954
GIT2	Q14161	414	464	414	463	Alternative sequence	ID=VSP_008654;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
GIT2	Q14161	414	464	415	449	Alternative sequence	ID=VSP_000306;Note=In isoform 4 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10896954;Dbxref=PMID:10896954
GIT2	Q14161	464	547	450	464	Alternative sequence	ID=VSP_000307;Note=In isoform 3%2C isoform 4%2C isoform 6 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	414	464	450	464	Alternative sequence	ID=VSP_000307;Note=In isoform 3%2C isoform 4%2C isoform 6 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	547	577	465	547	Alternative sequence	ID=VSP_000308;Note=In isoform 6%2C isoform 7 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	464	547	465	547	Alternative sequence	ID=VSP_000308;Note=In isoform 6%2C isoform 7 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	464	547	466	471	Alternative sequence	ID=VSP_000303;Note=In isoform 2. QTLQSE->LGKDAN;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	547	577	472	759	Alternative sequence	ID=VSP_000304;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	464	547	472	759	Alternative sequence	ID=VSP_000304;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:10896954,PMID:15489334
GIT2	Q14161	547	577	548	577	Alternative sequence	ID=VSP_000309;Note=In isoform 5%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10896954,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8590280;Dbxref=PMID:10896954,PMID:15489334,PMID:8590280
GIT2	Q14161	547	577	552	552	Natural variant	ID=VAR_048325;Note=A->V;Dbxref=dbSNP:rs11068997
TUBGCP3	Q96CW5	816	855	2	907	Chain	ID=PRO_0000078118;Note=Gamma-tubulin complex component 3
TUBGCP3	Q96CW5	725	769	2	907	Chain	ID=PRO_0000078118;Note=Gamma-tubulin complex component 3
TUBGCP3	Q96CW5	322	345	2	907	Chain	ID=PRO_0000078118;Note=Gamma-tubulin complex component 3
TUBGCP3	Q96CW5	816	855	825	829	Compositional bias	Note=Poly-Glu
TUBGCP3	Q96CW5	816	855	435	907	Alternative sequence	ID=VSP_001623;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TUBGCP3	Q96CW5	725	769	435	907	Alternative sequence	ID=VSP_001623;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TUBGCP3	Q96CW5	816	855	817	824	Alternative sequence	ID=VSP_001620;Note=In isoform 2. GQWGVTAA->VEMCLYCV;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9566969,ECO:0000303|Ref.3;Dbxref=PMID:15489334,PMID:9566969
TUBGCP3	Q96CW5	816	855	825	907	Alternative sequence	ID=VSP_001621;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9566969,ECO:0000303|Ref.3;Dbxref=PMID:15489334,PMID:9566969
TUBGCP6	Q96RT7	1542	1607	1	1819	Chain	ID=PRO_0000078131;Note=Gamma-tubulin complex component 6
HIRIP3	Q9BW71	469	502	1	556	Chain	ID=PRO_0000083989;Note=HIRA-interacting protein 3
HIRIP3	Q9BW71	469	502	471	471	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HIRIP3	Q9BW71	469	502	176	556	Alternative sequence	ID=VSP_046025;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
HIRIP3	Q9BW71	469	502	496	496	Natural variant	ID=VAR_051033;Note=A->V;Dbxref=dbSNP:rs35431046
ARHGDIA	P52565	63	91	2	204	Chain	ID=PRO_0000219013;Note=Rho GDP-dissociation inhibitor 1
ARHGDIA	P52565	63	91	2	204	Chain	ID=PRO_0000219013;Note=Rho GDP-dissociation inhibitor 1
ARHGDIA	P52565	63	91	2	204	Chain	ID=PRO_0000219013;Note=Rho GDP-dissociation inhibitor 1
ARHGDIA	P52565	63	91	59	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N80
ARHGDIA	P52565	63	91	59	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N80
ARHGDIA	P52565	63	91	59	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N80
ARHGDIA	P52565	63	91	69	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	69	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	69	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
ARHGDIA	P52565	63	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMT
GDAP1	Q8TB36	103	161	1	358	Chain	ID=PRO_0000186038;Note=Ganglioside-induced differentiation-associated protein 1
GDAP1	Q8TB36	103	161	24	105	Domain	Note=GST N-terminal
GDAP1	Q8TB36	103	161	153	309	Domain	Note=GST C-terminal
GDAP1	Q8TB36	103	161	120	120	Natural variant	ID=VAR_078265;Note=In CMT2K%3B dominant form. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26525999;Dbxref=PMID:26525999
GDAP1	Q8TB36	103	161	120	120	Natural variant	ID=VAR_017184;Note=In CMT4A%3B no effect on mitochondrial localization but impairment in the ability to induce mitochondrial fragmentation. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12601710,ECO:0000269|PubMed:15772096,ECO:0000269|PubMed:16172208;Dbxref=dbSNP:rs1174933176,PMID:12601710,PMID:15772096,PMID:16172208
GDAP1	Q8TB36	103	161	120	120	Natural variant	ID=VAR_078266;Note=In CMT2K%3B dominant form%3B no effect on mitochondrial localization. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15772096,ECO:0000269|PubMed:26525999,ECO:0000269|PubMed:28244113;Dbxref=dbSNP:rs104894078,PMID:15772096,PMID:26525999,PMID:28244113
GDAP1	Q8TB36	103	161	123	123	Natural variant	ID=VAR_078267;Note=In CMT2K%3B dominant form%3B. H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26525999,ECO:0000269|PubMed:28244113;Dbxref=dbSNP:rs397515442,PMID:26525999,PMID:28244113
GDAP1	Q8TB36	103	161	126	126	Natural variant	ID=VAR_078268;Note=In CMT2K%3B dominant form%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244113;Dbxref=dbSNP:rs879254005,PMID:28244113
GDAP1	Q8TB36	103	161	156	156	Natural variant	ID=VAR_078269;Note=In CMT2K%3B dominant form. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244113;Dbxref=dbSNP:rs397515441,PMID:28244113
GDAP1	Q8TB36	103	161	161	161	Natural variant	ID=VAR_017185;Note=In CMT4A%3B no effect on mitochondrial localization but abolishes mitochondrial fission. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11743579,ECO:0000269|PubMed:15772096,ECO:0000269|PubMed:16172208;Dbxref=dbSNP:rs104894076,PMID:11743579,PMID:15772096,PMID:16172208
GDAP1	Q8TB36	103	161	116	116	Mutagenesis	Note=Impairment in the ability to induce mitochondrial fragmentation. M->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16172208;Dbxref=PMID:16172208
GDAP1	Q8TB36	103	161	157	157	Mutagenesis	Note=No effect on mitochondrial localization. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15772096;Dbxref=PMID:15772096
GDAP1	Q8TB36	103	161	133	133	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPHN	Q9NQX3	67	98	1	736	Chain	ID=PRO_0000170964;Note=Gephyrin
GPHN	Q9NQX3	302	348	1	736	Chain	ID=PRO_0000170964;Note=Gephyrin
GPHN	Q9NQX3	348	379	1	736	Chain	ID=PRO_0000170964;Note=Gephyrin
GPHN	Q9NQX3	67	98	14	166	Region	Note=MPT Mo-transferase
GPHN	Q9NQX3	302	348	140	316	Region	Note=Interaction with GABARAP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GPHN	Q9NQX3	302	348	326	736	Region	Note=MPT adenylyltransferase
GPHN	Q9NQX3	348	379	326	736	Region	Note=MPT adenylyltransferase
GPHN	Q9NQX3	302	348	305	305	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GPHN	Q9NQX3	348	379	375	375	Natural variant	ID=VAR_075626;Note=In MOCODC%3B patient phenotype resembling Dravet syndrome%3B abolishes postsynaptic clustering of GPHN%3B decreases cell-surface expression of GABA receptors%3B impairs postsynaptic currents%3B catalytically inactive%3B decreases binding affinity toward GABRA3%3B decreases binding affinity toward GLRB. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26613940;Dbxref=PMID:26613940
GPHN	Q9NQX3	67	98	63	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JLJ
GPHN	Q9NQX3	67	98	80	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JLJ
GPHN	Q9NQX3	67	98	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JLJ
GPHN	Q9NQX3	67	98	96	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JLJ
GLT1D1	Q96MS3	156	188	17	346	Chain	ID=PRO_0000312203;Note=Glycosyltransferase 1 domain-containing protein 1
GLT1D1	Q96MS3	156	188	126	205	Alternative sequence	ID=VSP_029731;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GLT1D1	Q96MS3	156	188	153	346	Alternative sequence	ID=VSP_029733;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GIN1	Q9NXP7	277	336	1	522	Chain	ID=PRO_0000333016;Note=Gypsy retrotransposon integrase-like protein 1
GIN1	Q9NXP7	277	336	135	292	Domain	Note=Integrase catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00457
GIN1	Q9NXP7	277	336	81	522	Alternative sequence	ID=VSP_038519;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GIN1	Q9NXP7	277	336	223	522	Alternative sequence	ID=VSP_033439;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GIN1	Q9NXP7	277	336	313	313	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLB1L2	Q8IW92	29	94	1	32	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
GLB1L2	Q8IW92	29	94	33	636	Chain	ID=PRO_0000317513;Note=Beta-galactosidase-1-like protein 2
GLB1L2	Q8IW92	95	117	33	636	Chain	ID=PRO_0000317513;Note=Beta-galactosidase-1-like protein 2
GLB1L2	Q8IW92	569	608	33	636	Chain	ID=PRO_0000317513;Note=Beta-galactosidase-1-like protein 2
GLB1L2	Q8IW92	95	117	33	636	Chain	ID=PRO_0000317513;Note=Beta-galactosidase-1-like protein 2
GLB1L2	Q8IW92	569	608	33	636	Chain	ID=PRO_0000317513;Note=Beta-galactosidase-1-like protein 2
GLB1L2	Q8IW92	29	94	50	50	Sequence conflict	Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLB1L2	Q8IW92	95	117	117	117	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLB1L2	Q8IW92	95	117	117	117	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLOD5	A6NK44	67	119	1	160	Chain	ID=PRO_0000305326;Note=Glyoxalase domain-containing protein 5
GLOD5	A6NK44	67	119	37	157	Domain	Note=VOC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01163
GLOD5	A6NK44	67	119	67	69	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZW5
GLOD5	A6NK44	67	119	70	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZW5
GLOD5	A6NK44	67	119	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZW5
GLOD5	A6NK44	67	119	102	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZW5
GLOD5	A6NK44	67	119	111	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZW5
GLP2R	O95838	428	442	1	553	Chain	ID=PRO_0000012838;Note=Glucagon-like peptide 2 receptor
GLP2R	O95838	428	442	418	438	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLP2R	O95838	428	442	439	550	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
GYPC	P04921	35	63	1	128	Chain	ID=PRO_0000149050;Note=Glycophorin-C
GYPC	P04921	35	63	1	57	Topological domain	Note=Extracellular
GYPC	P04921	35	63	58	81	Transmembrane	Note=Helical%3B Signal-anchor for type III membrane protein
GYPC	P04921	35	63	42	42	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22171320,ECO:0000269|PubMed:3571235,ECO:0000269|PubMed:7106126;Dbxref=PMID:22171320,PMID:3571235,PMID:7106126
GYPC	P04921	35	63	18	36	Alternative sequence	ID=VSP_054790;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2349119;Dbxref=PMID:2349119
GK5	Q6ZS86	314	349	1	529	Chain	ID=PRO_0000323754;Note=Putative glycerol kinase 5
GK5	Q6ZS86	137	181	1	529	Chain	ID=PRO_0000323754;Note=Putative glycerol kinase 5
GK5	Q6ZS86	137	181	1	279	Alternative sequence	ID=VSP_032121;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GK5	Q6ZS86	314	349	302	529	Alternative sequence	ID=VSP_032123;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
GK5	Q6ZS86	314	349	339	339	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
DOK3	Q7L591	78	180	1	496	Chain	ID=PRO_0000187272;Note=Docking protein 3
DOK3	Q7L591	78	180	63	179	Domain	Note=PH
DOK3	Q7L591	78	180	1	170	Alternative sequence	ID=VSP_013713;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DOK3	Q7L591	78	180	79	180	Alternative sequence	ID=VSP_013714;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPEP1	P16444	197	256	17	385	Chain	ID=PRO_0000018652;Note=Dipeptidase 1
DPEP1	P16444	197	256	17	385	Chain	ID=PRO_0000018652;Note=Dipeptidase 1
DPEP1	P16444	197	256	17	385	Chain	ID=PRO_0000018652;Note=Dipeptidase 1
DPEP1	P16444	197	256	214	214	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	214	214	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	214	214	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	235	235	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	235	235	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	235	235	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	246	246	Binding site	Note=Substrate
DPEP1	P16444	197	256	246	246	Binding site	Note=Substrate
DPEP1	P16444	197	256	246	246	Binding site	Note=Substrate
DPEP1	P16444	197	256	242	274	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	242	274	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	242	274	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10073,ECO:0000269|PubMed:12144777;Dbxref=PMID:12144777
DPEP1	P16444	197	256	246	246	Natural variant	ID=VAR_036496;Note=In a colorectal cancer sample%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1043397364,PMID:16959974
DPEP1	P16444	197	256	246	246	Natural variant	ID=VAR_036496;Note=In a colorectal cancer sample%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1043397364,PMID:16959974
DPEP1	P16444	197	256	246	246	Natural variant	ID=VAR_036496;Note=In a colorectal cancer sample%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1043397364,PMID:16959974
DPEP1	P16444	197	256	194	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	194	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	194	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	209	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	209	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	209	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	217	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	217	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	217	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	239	241	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	239	241	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	239	241	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	250	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	250	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
DPEP1	P16444	197	256	250	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ITU
HMOX2	P30519	68	232	2	316	Chain	ID=PRO_0000209691;Note=Heme oxygenase 2
HMOX2	P30519	68	232	2	316	Chain	ID=PRO_0000209691;Note=Heme oxygenase 2
HMOX2	P30519	68	232	2	316	Chain	ID=PRO_0000209691;Note=Heme oxygenase 2
HMOX2	P30519	68	232	2	316	Chain	ID=PRO_0000209691;Note=Heme oxygenase 2
HMOX2	P30519	68	232	2	316	Chain	ID=PRO_0000209691;Note=Heme oxygenase 2
HMOX2	P30519	68	232	2	316	Chain	ID=PRO_0000209691;Note=Heme oxygenase 2
HMOX2	P30519	68	232	137	137	Natural variant	ID=VAR_021067;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17884623
HMOX2	P30519	68	232	137	137	Natural variant	ID=VAR_021067;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17884623
HMOX2	P30519	68	232	137	137	Natural variant	ID=VAR_021067;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17884623
HMOX2	P30519	68	232	137	137	Natural variant	ID=VAR_021067;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17884623
HMOX2	P30519	68	232	137	137	Natural variant	ID=VAR_021067;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17884623
HMOX2	P30519	68	232	137	137	Natural variant	ID=VAR_021067;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17884623
HMOX2	P30519	68	232	146	146	Natural variant	ID=VAR_021068;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17880805
HMOX2	P30519	68	232	146	146	Natural variant	ID=VAR_021068;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17880805
HMOX2	P30519	68	232	146	146	Natural variant	ID=VAR_021068;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17880805
HMOX2	P30519	68	232	146	146	Natural variant	ID=VAR_021068;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17880805
HMOX2	P30519	68	232	146	146	Natural variant	ID=VAR_021068;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17880805
HMOX2	P30519	68	232	146	146	Natural variant	ID=VAR_021068;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17880805
HMOX2	P30519	68	232	107	107	Sequence conflict	Note=E->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	107	107	Sequence conflict	Note=E->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	107	107	Sequence conflict	Note=E->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	107	107	Sequence conflict	Note=E->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	107	107	Sequence conflict	Note=E->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	107	107	Sequence conflict	Note=E->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	165	166	Sequence conflict	Note=QV->KC;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	165	166	Sequence conflict	Note=QV->KC;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	165	166	Sequence conflict	Note=QV->KC;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	165	166	Sequence conflict	Note=QV->KC;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	165	166	Sequence conflict	Note=QV->KC;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	165	166	Sequence conflict	Note=QV->KC;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	222	222	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	222	222	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	222	222	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	222	222	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	222	222	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	222	222	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMOX2	P30519	68	232	64	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	64	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	64	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	64	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	64	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	64	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	149	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	149	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	149	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	149	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	149	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	149	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	213	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	213	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	213	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	213	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	213	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMOX2	P30519	68	232	213	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UC9
HMGA1	P17096	45	73	2	107	Chain	ID=PRO_0000206708;Note=High mobility group protein HMG-I/HMG-Y
HMGA1	P17096	73	90	2	107	Chain	ID=PRO_0000206708;Note=High mobility group protein HMG-I/HMG-Y
HMGA1	P17096	45	73	2	107	Chain	ID=PRO_0000206708;Note=High mobility group protein HMG-I/HMG-Y
HMGA1	P17096	73	90	2	107	Chain	ID=PRO_0000206708;Note=High mobility group protein HMG-I/HMG-Y
HMGA1	P17096	45	73	53	63	DNA binding	Note=A.T hook 2
HMGA1	P17096	45	73	53	63	DNA binding	Note=A.T hook 2
HMGA1	P17096	73	90	78	89	DNA binding	Note=A.T hook 3
HMGA1	P17096	73	90	78	89	DNA binding	Note=A.T hook 3
HMGA1	P17096	45	73	53	77	Region	Note=Interaction with HIPK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
HMGA1	P17096	73	90	53	77	Region	Note=Interaction with HIPK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
HMGA1	P17096	45	73	53	77	Region	Note=Interaction with HIPK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
HMGA1	P17096	73	90	53	77	Region	Note=Interaction with HIPK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
HMGA1	P17096	45	73	49	49	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
HMGA1	P17096	45	73	49	49	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
HMGA1	P17096	45	73	53	53	Modified residue	Note=Phosphothreonine%3B by HIPK2 and CDC2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
HMGA1	P17096	45	73	53	53	Modified residue	Note=Phosphothreonine%3B by HIPK2 and CDC2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17924679,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
HMGA1	P17096	45	73	58	58	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	58	58	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	58	58	Modified residue	Note=Omega-N-methylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	58	58	Modified residue	Note=Omega-N-methylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	60	60	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	60	60	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	60	60	Modified residue	Note=Omega-N-methylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	60	60	Modified residue	Note=Omega-N-methylarginine%3B by PRMT6%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	73	90	78	78	Modified residue	Note=Phosphothreonine%3B by HIPK2 and CDC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12653562;Dbxref=PMID:12653562
HMGA1	P17096	73	90	78	78	Modified residue	Note=Phosphothreonine%3B by HIPK2 and CDC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12653562;Dbxref=PMID:12653562
HMGA1	P17096	45	73	35	45	Alternative sequence	ID=VSP_002182;Note=In isoform HMG-Y. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2505228,ECO:0000303|PubMed:2701943;Dbxref=PMID:15489334,PMID:2505228,PMID:2701943
HMGA1	P17096	45	73	35	45	Alternative sequence	ID=VSP_002182;Note=In isoform HMG-Y. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2505228,ECO:0000303|PubMed:2701943;Dbxref=PMID:15489334,PMID:2505228,PMID:2701943
HMGA1	P17096	45	73	66	107	Alternative sequence	ID=VSP_018084;Note=In isoform HMG-R. NKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ->KNWRRRKRRASRRSPRRRSSDPCVPPAPHWRSSFLLGLDSFAPLPPPPPLPQAHHHHRLWPPPPSSTCALTTTLHSTPAAAGLPWAEWGAVFPWPQFPAPPAHPRIHTCPPGQG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10428834;Dbxref=PMID:10428834
HMGA1	P17096	73	90	66	107	Alternative sequence	ID=VSP_018084;Note=In isoform HMG-R. NKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ->KNWRRRKRRASRRSPRRRSSDPCVPPAPHWRSSFLLGLDSFAPLPPPPPLPQAHHHHRLWPPPPSSTCALTTTLHSTPAAAGLPWAEWGAVFPWPQFPAPPAHPRIHTCPPGQG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10428834;Dbxref=PMID:10428834
HMGA1	P17096	45	73	66	107	Alternative sequence	ID=VSP_018084;Note=In isoform HMG-R. NKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ->KNWRRRKRRASRRSPRRRSSDPCVPPAPHWRSSFLLGLDSFAPLPPPPPLPQAHHHHRLWPPPPSSTCALTTTLHSTPAAAGLPWAEWGAVFPWPQFPAPPAHPRIHTCPPGQG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10428834;Dbxref=PMID:10428834
HMGA1	P17096	73	90	66	107	Alternative sequence	ID=VSP_018084;Note=In isoform HMG-R. NKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ->KNWRRRKRRASRRSPRRRSSDPCVPPAPHWRSSFLLGLDSFAPLPPPPPLPQAHHHHRLWPPPPSSTCALTTTLHSTPAAAGLPWAEWGAVFPWPQFPAPPAHPRIHTCPPGQG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10428834;Dbxref=PMID:10428834
HMGA1	P17096	45	73	58	58	Mutagenesis	Note=Decreases methylation by PRMT6. Abolishes methylation by PRMT6%3B when associated with A-60. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	58	58	Mutagenesis	Note=Decreases methylation by PRMT6. Abolishes methylation by PRMT6%3B when associated with A-60. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	60	60	Mutagenesis	Note=Decreases methylation by PRMT6. Abolishes methylation by PRMT6%3B when associated with A-58. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	60	60	Mutagenesis	Note=Decreases methylation by PRMT6. Abolishes methylation by PRMT6%3B when associated with A-58. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16159886;Dbxref=PMID:16159886
HMGA1	P17096	45	73	53	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EZE
HMGA1	P17096	45	73	53	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EZE
HOOK2	Q96ED9	609	646	1	719	Chain	ID=PRO_0000219194;Note=Protein Hook homolog 2
HOOK2	Q96ED9	173	200	1	719	Chain	ID=PRO_0000219194;Note=Protein Hook homolog 2
HOOK2	Q96ED9	173	200	1	548	Region	Note=Sufficient for interaction with microtubules
HOOK2	Q96ED9	609	646	533	719	Region	Note=Required for localization to the centrosome and induction of aggresome formation
HOOK2	Q96ED9	609	646	584	719	Region	Note=Sufficient for interaction with CNTRL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17140400;Dbxref=PMID:17140400
HOOK2	Q96ED9	173	200	180	427	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HNRNPM	P52272	298	332	2	730	Chain	ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M
HNRNPM	P52272	332	347	2	730	Chain	ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M
HNRNPM	P52272	373	391	2	730	Chain	ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M
HNRNPM	P52272	373	391	390	396	Compositional bias	Note=Poly-Gly
HNRNPM	P52272	373	391	377	377	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPM	P52272	332	347	345	345	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HNRNPM	P52272	373	391	381	381	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HNRNPM	P52272	373	391	388	388	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
HSP90AB1	P08238	49	118	2	724	Chain	ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
HSP90AB1	P08238	216	319	2	724	Chain	ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
HSP90AB1	P08238	49	118	2	724	Chain	ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
HSP90AB1	P08238	216	319	2	724	Chain	ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
HSP90AB1	P08238	49	118	2	724	Chain	ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
HSP90AB1	P08238	216	319	2	724	Chain	ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
HSP90AB1	P08238	49	118	2	527	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
HSP90AB1	P08238	216	319	2	527	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
HSP90AB1	P08238	49	118	2	527	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
HSP90AB1	P08238	216	319	2	527	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
HSP90AB1	P08238	49	118	2	527	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
HSP90AB1	P08238	216	319	2	527	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
HSP90AB1	P08238	49	118	2	214	Region	Note=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
HSP90AB1	P08238	49	118	2	214	Region	Note=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
HSP90AB1	P08238	49	118	2	214	Region	Note=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
HSP90AB1	P08238	216	319	215	552	Region	Note=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
HSP90AB1	P08238	216	319	215	552	Region	Note=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
HSP90AB1	P08238	216	319	215	552	Region	Note=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
HSP90AB1	P08238	49	118	88	88	Binding site	Note=ATP
HSP90AB1	P08238	49	118	88	88	Binding site	Note=ATP
HSP90AB1	P08238	49	118	88	88	Binding site	Note=ATP
HSP90AB1	P08238	49	118	107	107	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSP90AB1	P08238	49	118	107	107	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSP90AB1	P08238	49	118	107	107	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSP90AB1	P08238	216	319	219	219	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	219	219	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	219	219	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	226	226	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:18318008,PMID:20068231,PMID:21406692,PMID:23186163
HSP90AB1	P08238	216	319	226	226	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:18318008,PMID:20068231,PMID:21406692,PMID:23186163
HSP90AB1	P08238	216	319	226	226	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:18318008,PMID:20068231,PMID:21406692,PMID:23186163
HSP90AB1	P08238	216	319	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
HSP90AB1	P08238	216	319	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
HSP90AB1	P08238	216	319	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
HSP90AB1	P08238	216	319	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	297	297	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
HSP90AB1	P08238	216	319	297	297	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
HSP90AB1	P08238	216	319	297	297	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
HSP90AB1	P08238	216	319	301	301	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
HSP90AB1	P08238	216	319	301	301	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
HSP90AB1	P08238	216	319	301	301	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
HSP90AB1	P08238	216	319	305	305	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	305	305	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	305	305	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
HSP90AB1	P08238	216	319	307	307	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
HSP90AB1	P08238	216	319	307	307	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
HSP90AB1	P08238	216	319	307	307	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
HSP90AB1	P08238	49	118	88	88	Mutagenesis	Note=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
HSP90AB1	P08238	49	118	88	88	Mutagenesis	Note=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
HSP90AB1	P08238	49	118	88	88	Mutagenesis	Note=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
HSP90AB1	P08238	216	319	226	226	Mutagenesis	Note=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	226	226	Mutagenesis	Note=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	226	226	Mutagenesis	Note=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	226	226	Mutagenesis	Note=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	226	226	Mutagenesis	Note=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	226	226	Mutagenesis	Note=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	255	255	Mutagenesis	Note=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	255	255	Mutagenesis	Note=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	255	255	Mutagenesis	Note=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	255	255	Mutagenesis	Note=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	255	255	Mutagenesis	Note=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	255	255	Mutagenesis	Note=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
HSP90AB1	P08238	216	319	301	301	Mutagenesis	Note=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
HSP90AB1	P08238	216	319	301	301	Mutagenesis	Note=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
HSP90AB1	P08238	216	319	301	301	Mutagenesis	Note=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
HSP90AB1	P08238	49	118	38	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	38	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	38	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	62	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	62	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	62	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	73	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	73	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	73	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	79	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	79	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	79	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	95	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	95	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	95	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	49	118	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
HSP90AB1	P08238	216	319	288	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	288	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	288	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	298	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	298	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	298	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	316	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	316	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSP90AB1	P08238	216	319	316	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
HSPA14	Q0VDF9	156	190	1	509	Chain	ID=PRO_0000289946;Note=Heat shock 70 kDa protein 14
HSPA14	Q0VDF9	245	296	1	509	Chain	ID=PRO_0000289946;Note=Heat shock 70 kDa protein 14
HSPA14	Q0VDF9	245	296	282	282	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPA8	P11142	137	188	2	646	Chain	ID=PRO_0000078270;Note=Heat shock cognate 71 kDa protein
HSPA8	P11142	137	188	2	646	Chain	ID=PRO_0000078270;Note=Heat shock cognate 71 kDa protein
HSPA8	P11142	137	188	2	646	Chain	ID=PRO_0000078270;Note=Heat shock cognate 71 kDa protein
HSPA8	P11142	137	188	2	386	Region	Note=Nucleotide-binding domain (NBD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27474739;Dbxref=PMID:27474739
HSPA8	P11142	137	188	2	386	Region	Note=Nucleotide-binding domain (NBD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27474739;Dbxref=PMID:27474739
HSPA8	P11142	137	188	2	386	Region	Note=Nucleotide-binding domain (NBD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27474739;Dbxref=PMID:27474739
HSPA8	P11142	137	188	186	377	Region	Note=Interaction with BAG1
HSPA8	P11142	137	188	186	377	Region	Note=Interaction with BAG1
HSPA8	P11142	137	188	186	377	Region	Note=Interaction with BAG1
HSPA8	P11142	137	188	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
HSPA8	P11142	137	188	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
HSPA8	P11142	137	188	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
HSPA8	P11142	137	188	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQF
HSPA8	P11142	137	188	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQF
HSPA8	P11142	137	188	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQF
HSPA8	P11142	137	188	141	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	141	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	141	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	152	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	152	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	152	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	168	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	168	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	168	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	175	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	175	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	175	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQM
HSPA8	P11142	137	188	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQL
HSPA8	P11142	137	188	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQL
HSPA8	P11142	137	188	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AQL
MCCC1	Q96RQ3	659	683	42	725	Chain	ID=PRO_0000002833;Note=Methylcrotonoyl-CoA carboxylase subunit alpha%2C mitochondrial
MCCC1	Q96RQ3	623	659	42	725	Chain	ID=PRO_0000002833;Note=Methylcrotonoyl-CoA carboxylase subunit alpha%2C mitochondrial
MCCC1	Q96RQ3	531	560	42	725	Chain	ID=PRO_0000002833;Note=Methylcrotonoyl-CoA carboxylase subunit alpha%2C mitochondrial
MCCC1	Q96RQ3	91	123	42	725	Chain	ID=PRO_0000002833;Note=Methylcrotonoyl-CoA carboxylase subunit alpha%2C mitochondrial
MCCC1	Q96RQ3	91	123	48	494	Domain	Note=Biotin carboxylation
MCCC1	Q96RQ3	659	683	643	715	Domain	Note=Biotinyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066
MCCC1	Q96RQ3	623	659	643	715	Domain	Note=Biotinyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066
MCCC1	Q96RQ3	659	683	681	681	Modified residue	Note=N6-biotinyllysine;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250,ECO:0000255|PROSITE-ProRule:PRU01066
MCCC1	Q96RQ3	91	123	120	120	Natural variant	ID=VAR_077285;Note=In MCC1D. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27601257;Dbxref=PMID:27601257
MCCC1	Q96RQ3	91	123	123	123	Natural variant	ID=VAR_072489;Note=In MCC1D. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22642865;Dbxref=PMID:22642865
MCCC1	Q96RQ3	531	560	532	532	Natural variant	ID=VAR_012790;Note=In MCC1D%3B severe form. D->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11181649,ECO:0000269|PubMed:22642865;Dbxref=dbSNP:rs119103214,PMID:11181649,PMID:22642865
MCCC1	Q96RQ3	531	560	535	535	Natural variant	ID=VAR_012791;Note=In MCC1D%3B asymptomatic form. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11406611,ECO:0000269|PubMed:22642865;Dbxref=dbSNP:rs119103216,PMID:11406611,PMID:22642865
MCCC1	Q96RQ3	531	560	560	560	Natural variant	ID=VAR_038631;Note=N->T;Dbxref=dbSNP:rs35219417
MCCC1	Q96RQ3	623	659	632	632	Natural variant	ID=VAR_079752;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28887846;Dbxref=dbSNP:rs142867987,PMID:28887846
MCCC1	Q96RQ3	659	683	652	660	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJM
MCCC1	Q96RQ3	623	659	652	660	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJM
MCCC1	Q96RQ3	659	683	666	668	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJM
MCCC1	Q96RQ3	659	683	673	687	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EJM
HTRA3	P83110	301	312	18	453	Chain	ID=PRO_0000026949;Note=Serine protease HTRA3
HTRA3	P83110	367	398	18	453	Chain	ID=PRO_0000026949;Note=Serine protease HTRA3
HTRA3	P83110	367	398	359	444	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
HTRA3	P83110	301	312	175	340	Region	Note=Serine protease
HTRA3	P83110	301	312	305	305	Active site	Note=Charge relay system;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22229724,ECO:0000269|PubMed:26110759;Dbxref=PMID:22229724,PMID:26110759
HTRA3	P83110	367	398	358	453	Alternative sequence	ID=VSP_012571;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12513693;Dbxref=PMID:12513693
HTRA3	P83110	301	312	305	305	Mutagenesis	Note=Abolishes protease activity. Stabilizes the protein. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22229724;Dbxref=PMID:22229724
HTRA3	P83110	301	312	302	306	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RI0
HTRA3	P83110	301	312	307	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RI0
HTRA3	P83110	367	398	366	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P3W
HTRA3	P83110	367	398	384	391	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P3W
HTRA3	P83110	367	398	396	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P3W
GMPPA	Q96IJ6	207	251	1	420	Chain	ID=PRO_0000327872;Note=Mannose-1-phosphate guanyltransferase alpha
GMPPA	Q96IJ6	207	251	1	420	Chain	ID=PRO_0000327872;Note=Mannose-1-phosphate guanyltransferase alpha
GMPPA	Q96IJ6	207	251	1	420	Chain	ID=PRO_0000327872;Note=Mannose-1-phosphate guanyltransferase alpha
GMPPA	Q96IJ6	207	251	1	420	Chain	ID=PRO_0000327872;Note=Mannose-1-phosphate guanyltransferase alpha
GOLGA2	Q08379	736	809	1	1002	Chain	ID=PRO_0000190054;Note=Golgin subfamily A member 2
GOLGA2	Q08379	597	672	1	1002	Chain	ID=PRO_0000190054;Note=Golgin subfamily A member 2
GOLGA2	Q08379	351	381	1	1002	Chain	ID=PRO_0000190054;Note=Golgin subfamily A member 2
GOLGA2	Q08379	187	200	1	1002	Chain	ID=PRO_0000190054;Note=Golgin subfamily A member 2
GOLGA2	Q08379	160	187	1	1002	Chain	ID=PRO_0000190054;Note=Golgin subfamily A member 2
GOLGA2	Q08379	69	104	1	1002	Chain	ID=PRO_0000190054;Note=Golgin subfamily A member 2
GOLGA2	Q08379	69	104	1	84	Region	Note=Interaction with p115/USO1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62839
GOLGA2	Q08379	736	809	16	892	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA2	Q08379	597	672	16	892	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA2	Q08379	351	381	16	892	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA2	Q08379	187	200	16	892	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA2	Q08379	160	187	16	892	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA2	Q08379	69	104	16	892	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA2	Q08379	351	381	1	382	Alternative sequence	ID=VSP_007727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8315394;Dbxref=PMID:8315394
GOLGA2	Q08379	187	200	1	382	Alternative sequence	ID=VSP_007727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8315394;Dbxref=PMID:8315394
GOLGA2	Q08379	160	187	1	382	Alternative sequence	ID=VSP_007727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8315394;Dbxref=PMID:8315394
GOLGA2	Q08379	69	104	1	382	Alternative sequence	ID=VSP_007727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8315394;Dbxref=PMID:8315394
GOLGA2	Q08379	736	809	762	762	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
GOLGA5	Q8TBA6	181	257	2	731	Chain	ID=PRO_0000190061;Note=Golgin subfamily A member 5
GOLGA5	Q8TBA6	440	497	2	731	Chain	ID=PRO_0000190061;Note=Golgin subfamily A member 5
GOLGA5	Q8TBA6	497	540	2	731	Chain	ID=PRO_0000190061;Note=Golgin subfamily A member 5
GOLGA5	Q8TBA6	181	257	2	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA5	Q8TBA6	440	497	2	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA5	Q8TBA6	497	540	2	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA5	Q8TBA6	181	257	216	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA5	Q8TBA6	440	497	216	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA5	Q8TBA6	497	540	216	632	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGA5	Q8TBA6	440	497	497	498	Site	Note=Breakpoint for translocation to form RET-GOLGA5 oncogene
GOLGA5	Q8TBA6	497	540	497	498	Site	Note=Breakpoint for translocation to form RET-GOLGA5 oncogene
GOLGA5	Q8TBA6	440	497	486	486	Natural variant	ID=VAR_055860;Note=M->V;Dbxref=dbSNP:rs34139657
GOLGB1	Q14789	3135	3179	1	3259	Chain	ID=PRO_0000190071;Note=Golgin subfamily B member 1
GOLGB1	Q14789	216	252	1	3259	Chain	ID=PRO_0000190071;Note=Golgin subfamily B member 1
GOLGB1	Q14789	3135	3179	1	3235	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGB1	Q14789	216	252	1	3235	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGB1	Q14789	216	252	48	593	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGB1	Q14789	3135	3179	1828	3185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLGB1	Q14789	216	252	216	251	Alternative sequence	ID=VSP_057418;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21697133;Dbxref=PMID:21697133
GOLIM4	O00461	620	647	2	696	Chain	ID=PRO_0000285097;Note=Golgi integral membrane protein 4
GOLIM4	O00461	597	620	2	696	Chain	ID=PRO_0000285097;Note=Golgi integral membrane protein 4
GOLIM4	O00461	228	281	2	696	Chain	ID=PRO_0000285097;Note=Golgi integral membrane protein 4
GOLIM4	O00461	200	228	2	696	Chain	ID=PRO_0000285097;Note=Golgi integral membrane protein 4
GOLIM4	O00461	620	647	34	696	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLIM4	O00461	597	620	34	696	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLIM4	O00461	228	281	34	696	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLIM4	O00461	200	228	34	696	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLIM4	O00461	228	281	176	248	Region	Note=Golgi targeting
GOLIM4	O00461	200	228	176	248	Region	Note=Golgi targeting
GOLIM4	O00461	228	281	35	244	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLIM4	O00461	200	228	35	244	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLIM4	O00461	620	647	311	681	Compositional bias	Note=Glu-rich
GOLIM4	O00461	597	620	311	681	Compositional bias	Note=Glu-rich
GOLIM4	O00461	597	620	613	613	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GOLIM4	O00461	620	647	626	626	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GOLIM4	O00461	228	281	257	257	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	252	338	1	401	Chain	ID=PRO_0000021356;Note=Golgi membrane protein 1
GOLM1	Q8NBJ4	43	103	1	401	Chain	ID=PRO_0000021356;Note=Golgi membrane protein 1
GOLM1	Q8NBJ4	252	338	1	401	Chain	ID=PRO_0000021356;Note=Golgi membrane protein 1
GOLM1	Q8NBJ4	43	103	1	401	Chain	ID=PRO_0000021356;Note=Golgi membrane protein 1
GOLM1	Q8NBJ4	252	338	36	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	43	103	36	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	252	338	36	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	43	103	36	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	43	103	40	205	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	43	103	40	205	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GOLM1	Q8NBJ4	252	338	309	309	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
GOLM1	Q8NBJ4	252	338	309	309	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
GPR107	Q5VW38	188	207	40	600	Chain	ID=PRO_0000021340;Note=Protein GPR107
GPR107	Q5VW38	207	243	40	600	Chain	ID=PRO_0000021340;Note=Protein GPR107
GPR107	Q5VW38	188	207	40	263	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR107	Q5VW38	207	243	40	263	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR107	Q5VW38	207	243	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR107	Q5VW38	188	207	109	228	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25031321;Dbxref=PMID:25031321
GPR107	Q5VW38	207	243	109	228	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25031321;Dbxref=PMID:25031321
GPR107	Q5VW38	188	207	189	189	Natural variant	ID=VAR_030863;Note=A->P;Dbxref=dbSNP:rs640343
EIF4E2	O60573	45	90	1	245	Chain	ID=PRO_0000193664;Note=Eukaryotic translation initiation factor 4E type 2
EIF4E2	O60573	90	125	1	245	Chain	ID=PRO_0000193664;Note=Eukaryotic translation initiation factor 4E type 2
EIF4E2	O60573	45	90	54	57	Region	Note=EIF4EBP1/2/3 binding
EIF4E2	O60573	45	90	78	79	Region	Note=7-methylguanosine-containing mRNA cap binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4E2	O60573	90	125	95	99	Region	Note=EIF4EBP1/2/3 binding
EIF4E2	O60573	90	125	124	125	Region	Note=7-methylguanosine-containing mRNA cap binding
EIF4E2	O60573	90	125	110	110	Binding site	Note=7-methylguanosine-containing mRNA cap
EIF4E2	O60573	45	90	63	63	Mutagenesis	Note=Unable to bind capped mRNA. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	95	95	Mutagenesis	Note=Ability to bind capped mRNA reduced to 40%25 of wild-type. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	121	121	Mutagenesis	Note=Does not affect ubiquitination by ARIH1%3B when associated with R-130%3B R-134 and R-222. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25624349;Dbxref=PMID:25624349
EIF4E2	O60573	90	125	124	126	Mutagenesis	Note=Unable to bind capped mRNA. WED->FAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	124	124	Mutagenesis	Note=Ability to bind capped mRNA reduced to less than 10%25 of wild-type. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	124	124	Mutagenesis	Note=Ability to bind capped mRNA reduced to 13%25 of wild-type. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	125	125	Mutagenesis	Note=Ability to bind capped mRNA reduced to less than 10%25 of wild-type. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	45	90	55	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	45	90	75	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	45	90	82	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	82	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	91	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	104	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	109	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E3	Q8N5X7	157	209	1	224	Chain	ID=PRO_0000287697;Note=Eukaryotic translation initiation factor 4E type 3
EIF4E3	Q8N5X7	157	209	169	174	Region	Note=7-methylguanosine-containing mRNA cap binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
GXYLT2	A0PJZ3	156	200	1	443	Chain	ID=PRO_0000288539;Note=Glucoside xylosyltransferase 2
GXYLT2	A0PJZ3	200	284	1	443	Chain	ID=PRO_0000288539;Note=Glucoside xylosyltransferase 2
GXYLT2	A0PJZ3	156	200	26	443	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GXYLT2	A0PJZ3	200	284	26	443	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GXYLT2	A0PJZ3	200	284	233	233	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GXYLT2	A0PJZ3	200	284	274	274	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GYS1	P13807	436	474	1	737	Chain	ID=PRO_0000194763;Note=Glycogen [starch] synthase%2C muscle
GYS1	P13807	390	409	1	737	Chain	ID=PRO_0000194763;Note=Glycogen [starch] synthase%2C muscle
GYS1	P13807	164	226	1	737	Chain	ID=PRO_0000194763;Note=Glycogen [starch] synthase%2C muscle
GYS1	P13807	100	164	1	737	Chain	ID=PRO_0000194763;Note=Glycogen [starch] synthase%2C muscle
GYS1	P13807	164	226	101	164	Alternative sequence	ID=VSP_042745;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GYS1	P13807	100	164	101	164	Alternative sequence	ID=VSP_042745;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GYS1	P13807	100	164	108	108	Natural variant	ID=VAR_037958;Note=I->M;Dbxref=dbSNP:rs5455
GYS1	P13807	100	164	130	130	Natural variant	ID=VAR_014727;Note=K->E;Dbxref=dbSNP:rs5456
GYS1	P13807	436	474	464	464	Natural variant	ID=VAR_007859;Note=In NIDDM. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7657035;Dbxref=dbSNP:rs200862074,PMID:7657035
GYS1	P13807	100	164	136	136	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYS1	P13807	100	164	136	136	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
GYS1	P13807	436	474	462	462	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HABP2	Q14520	35	74	24	313	Chain	ID=PRO_0000027899;Note=Hyaluronan-binding protein 2 50 kDa heavy chain
HABP2	Q14520	149	189	24	313	Chain	ID=PRO_0000027899;Note=Hyaluronan-binding protein 2 50 kDa heavy chain
HABP2	Q14520	35	74	27	313	Chain	ID=PRO_0000027900;Note=Hyaluronan-binding protein 2 50 kDa heavy chain alternate form;Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	149	189	27	313	Chain	ID=PRO_0000027900;Note=Hyaluronan-binding protein 2 50 kDa heavy chain alternate form;Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	412	457	314	560	Chain	ID=PRO_0000027901;Note=Hyaluronan-binding protein 2 27 kDa light chain
HABP2	Q14520	412	457	320	560	Chain	ID=PRO_0000027902;Note=Hyaluronan-binding protein 2 27 kDa light chain alternate form;Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	35	74	73	109	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HABP2	Q14520	149	189	150	188	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HABP2	Q14520	412	457	314	555	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
HABP2	Q14520	149	189	169	170	Site	Note=Cleavage;Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	149	189	170	171	Site	Note=Cleavage;Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	35	74	54	54	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HABP2	Q14520	149	189	154	165	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	149	189	159	176	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	149	189	178	187	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	412	457	301	435	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000255,ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000255|PROSITE-ProRule:PRU00121,ECO:0000255|PROSITE-ProRule:PRU00274
HABP2	Q14520	412	457	447	515	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HABP2	Q14520	149	189	157	157	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HHATL	Q9HCP6	96	161	1	504	Chain	ID=PRO_0000213130;Note=Protein-cysteine N-palmitoyltransferase HHAT-like protein
HHATL	Q9HCP6	96	161	1	504	Chain	ID=PRO_0000213130;Note=Protein-cysteine N-palmitoyltransferase HHAT-like protein
HHATL	Q9HCP6	96	161	100	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HHATL	Q9HCP6	96	161	100	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HHATL	Q9HCP6	96	161	127	149	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HHATL	Q9HCP6	96	161	127	149	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HMGCS1	Q01581	149	191	1	520	Chain	ID=PRO_0000213747;Note=Hydroxymethylglutaryl-CoA synthase%2C cytoplasmic
HMGCS1	Q01581	149	191	1	520	Chain	ID=PRO_0000213747;Note=Hydroxymethylglutaryl-CoA synthase%2C cytoplasmic
HMGCS1	Q01581	149	191	167	167	Binding site	Note=Coenzyme A;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2P8U,ECO:0000269|PubMed:20346956;Dbxref=PMID:20346956
HMGCS1	Q01581	149	191	167	167	Binding site	Note=Coenzyme A;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2P8U,ECO:0000269|PubMed:20346956;Dbxref=PMID:20346956
HMGCS1	Q01581	149	191	152	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	152	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	169	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	169	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	173	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	173	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	186	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGCS1	Q01581	149	191	186	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8U
HMGXB4	Q9UGU5	546	587	1	601	Chain	ID=PRO_0000048542;Note=HMG domain-containing protein 4
HMCN1	Q96RW7	1543	1636	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	2763	2828	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	3894	3949	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	4437	4527	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	5085	5106	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	5106	5146	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	5146	5191	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	5314	5431	22	5635	Chain	ID=PRO_0000045391;Note=Hemicentin-1
HMCN1	Q96RW7	1543	1636	1546	1634	Domain	Note=Ig-like C2-type 13
HMCN1	Q96RW7	2763	2828	2666	2763	Domain	Note=Ig-like C2-type 25
HMCN1	Q96RW7	2763	2828	2766	2864	Domain	Note=Ig-like C2-type 26
HMCN1	Q96RW7	3894	3949	3897	3983	Domain	Note=Ig-like C2-type 38
HMCN1	Q96RW7	4437	4527	4440	4527	Domain	Note=Ig-like C2-type 44
HMCN1	Q96RW7	5085	5106	4871	5093	Domain	Note=Nidogen G2 beta-barrel;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00348
HMCN1	Q96RW7	5106	5146	5107	5146	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HMCN1	Q96RW7	5146	5191	5107	5146	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HMCN1	Q96RW7	5146	5191	5147	5191	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HMCN1	Q96RW7	5314	5431	5315	5355	Domain	Note=EGF-like 6%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HMCN1	Q96RW7	1543	1636	1552	1552	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HMCN1	Q96RW7	4437	4527	4491	4491	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HMCN1	Q96RW7	1543	1636	1569	1618	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	2763	2828	2799	2848	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	3894	3949	3918	3967	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	4437	4527	4461	4509	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	5106	5146	5111	5121	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	5106	5146	5117	5130	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	5106	5146	5132	5145	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	5314	5431	5319	5330	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	5314	5431	5326	5339	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	5314	5431	5341	5354	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HMCN1	Q96RW7	1543	1636	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	2763	2828	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	3894	3949	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	4437	4527	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	5085	5106	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	5106	5146	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	5146	5191	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	5314	5431	1172	5635	Alternative sequence	ID=VSP_016873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMCN1	Q96RW7	5314	5431	5315	5431	Alternative sequence	ID=VSP_016874;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMCN1	Q96RW7	1543	1636	1624	1624	Natural variant	ID=VAR_024811;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14570714;Dbxref=PMID:14570714
HMCN1	Q96RW7	4437	4527	4437	4437	Natural variant	ID=VAR_049877;Note=Q->R;Dbxref=dbSNP:rs10911825
HMCN1	Q96RW7	5085	5106	5087	5087	Natural variant	ID=VAR_024817;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14570714;Dbxref=dbSNP:rs41317507,PMID:14570714
HMCN1	Q96RW7	5314	5431	5345	5345	Natural variant	ID=VAR_024818;Note=In ARMD1. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14570714;Dbxref=dbSNP:rs121434382,PMID:14570714
HMCN1	Q96RW7	1543	1636	1570	1570	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMCN1	Q96RW7	5314	5431	5317	5317	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
HOMER1	Q86YM7	98	129	2	354	Chain	ID=PRO_0000191005;Note=Homer protein homolog 1
HOMER1	Q86YM7	98	129	1	110	Domain	Note=WH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00410
HOMER1	Q86YM7	98	129	99	228	Alternative sequence	ID=VSP_009057;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
HNMT	P50135	63	99	1	292	Chain	ID=PRO_0000084021;Note=Histamine N-methyltransferase
HNMT	P50135	63	99	1	292	Chain	ID=PRO_0000084021;Note=Histamine N-methyltransferase
HNMT	P50135	63	99	89	89	Binding site	Note=S-adenosyl-L-methionine
HNMT	P50135	63	99	89	89	Binding site	Note=S-adenosyl-L-methionine
HNMT	P50135	63	99	94	94	Binding site	Note=S-adenosyl-L-methionine
HNMT	P50135	63	99	94	94	Binding site	Note=S-adenosyl-L-methionine
HNMT	P50135	63	99	52	292	Alternative sequence	ID=VSP_043483;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HNMT	P50135	63	99	52	292	Alternative sequence	ID=VSP_043483;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HNMT	P50135	63	99	64	292	Alternative sequence	ID=VSP_042027;Note=In isoform 2. GEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA->DCLIRGSSRVLKRNSCFILCSTRQKDKPGMRIHDERSSELPFGAARLESKSAFPSFLVSFILF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14667820;Dbxref=PMID:14667820
HNMT	P50135	63	99	64	292	Alternative sequence	ID=VSP_042027;Note=In isoform 2. GEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA->DCLIRGSSRVLKRNSCFILCSTRQKDKPGMRIHDERSSELPFGAARLESKSAFPSFLVSFILF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14667820;Dbxref=PMID:14667820
HNMT	P50135	63	99	65	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AOT
HNMT	P50135	63	99	65	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AOT
HNMT	P50135	63	99	82	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AOT
HNMT	P50135	63	99	82	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AOT
HNMT	P50135	63	99	92	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AOT
HNMT	P50135	63	99	92	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AOT
HNRNPDL	O14979	340	397	1	420	Chain	ID=PRO_0000287239;Note=Heterogeneous nuclear ribonucleoprotein D-like
HNRNPDL	O14979	258	302	1	420	Chain	ID=PRO_0000287239;Note=Heterogeneous nuclear ribonucleoprotein D-like
HNRNPDL	O14979	204	258	1	420	Chain	ID=PRO_0000287239;Note=Heterogeneous nuclear ribonucleoprotein D-like
HNRNPDL	O14979	340	397	1	420	Chain	ID=PRO_0000287239;Note=Heterogeneous nuclear ribonucleoprotein D-like
HNRNPDL	O14979	258	302	1	420	Chain	ID=PRO_0000287239;Note=Heterogeneous nuclear ribonucleoprotein D-like
HNRNPDL	O14979	204	258	1	420	Chain	ID=PRO_0000287239;Note=Heterogeneous nuclear ribonucleoprotein D-like
HNRNPDL	O14979	204	258	148	230	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPDL	O14979	204	258	148	230	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPDL	O14979	258	302	233	312	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPDL	O14979	204	258	233	312	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPDL	O14979	258	302	233	312	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPDL	O14979	204	258	233	312	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPDL	O14979	340	397	342	420	Region	Note=Necessary for interaction with TNPO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9524220;Dbxref=PMID:9524220
HNRNPDL	O14979	340	397	342	420	Region	Note=Necessary for interaction with TNPO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9524220;Dbxref=PMID:9524220
HNRNPDL	O14979	340	397	396	420	Region	Note=Necessary for its nuclear import and export
HNRNPDL	O14979	340	397	396	420	Region	Note=Necessary for its nuclear import and export
HNRNPDL	O14979	340	397	323	411	Compositional bias	Note=Gly-rich
HNRNPDL	O14979	340	397	323	411	Compositional bias	Note=Gly-rich
HNRNPDL	O14979	340	397	353	396	Compositional bias	Note=Tyr-rich
HNRNPDL	O14979	340	397	353	396	Compositional bias	Note=Tyr-rich
HNRNPDL	O14979	204	258	216	216	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HNRNPDL	O14979	204	258	216	216	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HNRNPDL	O14979	204	258	241	241	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
HNRNPDL	O14979	204	258	241	241	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
HNRNPDL	O14979	204	258	209	209	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HNRNPDL	O14979	204	258	209	209	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HNRNPDL	O14979	340	397	341	397	Alternative sequence	ID=VSP_025411;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11705999;Dbxref=PMID:11705999
HNRNPDL	O14979	340	397	341	397	Alternative sequence	ID=VSP_025411;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11705999;Dbxref=PMID:11705999
HNRNPDL	O14979	340	397	378	378	Natural variant	ID=VAR_072567;Note=In LGMD1G. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24647604;Dbxref=dbSNP:rs587777669,PMID:24647604
HNRNPDL	O14979	340	397	378	378	Natural variant	ID=VAR_072567;Note=In LGMD1G. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24647604;Dbxref=dbSNP:rs587777669,PMID:24647604
HNRNPDL	O14979	340	397	378	378	Natural variant	ID=VAR_072568;Note=In LGMD1G. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24647604;Dbxref=dbSNP:rs587777669,PMID:24647604
HNRNPDL	O14979	340	397	378	378	Natural variant	ID=VAR_072568;Note=In LGMD1G. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24647604;Dbxref=dbSNP:rs587777669,PMID:24647604
HPS3	Q969F9	624	702	1	1004	Chain	ID=PRO_0000084050;Note=Hermansky-Pudlak syndrome 3 protein
HPS3	Q969F9	863	932	1	1004	Chain	ID=PRO_0000084050;Note=Hermansky-Pudlak syndrome 3 protein
HPS3	Q969F9	863	932	864	890	Alternative sequence	ID=VSP_003878;Note=In isoform 2. SLICGPSFDIASIIPFLEPLSEDTIAG->LPLFRSWSHFQKTLLPASVSMFCVVHA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HPS3	Q969F9	863	932	891	1004	Alternative sequence	ID=VSP_003879;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HPS4	Q9NQG7	44	92	1	708	Chain	ID=PRO_0000084052;Note=Hermansky-Pudlak syndrome 4 protein
HPS4	Q9NQG7	44	92	1	708	Chain	ID=PRO_0000084052;Note=Hermansky-Pudlak syndrome 4 protein
HPSE2	Q8WWQ2	489	537	42	592	Chain	ID=PRO_0000068140;Note=Inactive heparanase-2
HPSE2	Q8WWQ2	203	261	42	592	Chain	ID=PRO_0000068140;Note=Inactive heparanase-2
HPSE2	Q8WWQ2	149	203	42	592	Chain	ID=PRO_0000068140;Note=Inactive heparanase-2
HPSE2	Q8WWQ2	203	261	254	254	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPSE2	Q8WWQ2	203	261	150	261	Alternative sequence	ID=VSP_015850;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11027606;Dbxref=PMID:11027606
HPSE2	Q8WWQ2	149	203	150	261	Alternative sequence	ID=VSP_015850;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11027606;Dbxref=PMID:11027606
HPSE2	Q8WWQ2	203	261	204	261	Alternative sequence	ID=VSP_015851;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11027606;Dbxref=PMID:11027606
HPSE2	Q8WWQ2	203	261	213	213	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HPSE2	Q8WWQ2	203	261	213	213	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MVB12B	Q9H7P6	180	220	1	319	Chain	ID=PRO_0000249074;Note=Multivesicular body subunit 12B
MVB12B	Q9H7P6	180	220	47	193	Domain	Note=MABP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00831
MVB12B	Q9H7P6	180	220	204	204	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005716;Dbxref=PMID:18005716
MVB12B	Q9H7P6	180	220	205	205	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005716;Dbxref=PMID:18005716
MVB12B	Q9H7P6	180	220	176	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TOW
MVB12B	Q9H7P6	180	220	185	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TOW
HHLA2	Q9UM44	334	369	23	414	Chain	ID=PRO_0000249709;Note=HERV-H LTR-associating protein 2
HHLA2	Q9UM44	369	386	23	414	Chain	ID=PRO_0000249709;Note=HERV-H LTR-associating protein 2
HHLA2	Q9UM44	334	369	23	414	Chain	ID=PRO_0000249709;Note=HERV-H LTR-associating protein 2
HHLA2	Q9UM44	369	386	23	414	Chain	ID=PRO_0000249709;Note=HERV-H LTR-associating protein 2
HHLA2	Q9UM44	334	369	23	414	Chain	ID=PRO_0000249709;Note=HERV-H LTR-associating protein 2
HHLA2	Q9UM44	369	386	23	414	Chain	ID=PRO_0000249709;Note=HERV-H LTR-associating protein 2
HHLA2	Q9UM44	334	369	345	365	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HHLA2	Q9UM44	334	369	345	365	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HHLA2	Q9UM44	334	369	345	365	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HHLA2	Q9UM44	334	369	344	344	Natural variant	ID=VAR_027488;Note=N->K;Dbxref=dbSNP:rs3792332
HHLA2	Q9UM44	334	369	344	344	Natural variant	ID=VAR_027488;Note=N->K;Dbxref=dbSNP:rs3792332
HHLA2	Q9UM44	334	369	344	344	Natural variant	ID=VAR_027488;Note=N->K;Dbxref=dbSNP:rs3792332
HHLA2	Q9UM44	334	369	364	364	Natural variant	ID=VAR_027489;Note=S->R;Dbxref=dbSNP:rs6779094
HHLA2	Q9UM44	334	369	364	364	Natural variant	ID=VAR_027489;Note=S->R;Dbxref=dbSNP:rs6779094
HHLA2	Q9UM44	334	369	364	364	Natural variant	ID=VAR_027489;Note=S->R;Dbxref=dbSNP:rs6779094
HLTF	Q14527	932	959	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	631	690	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	428	458	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	932	959	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	631	690	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	428	458	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	932	959	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	631	690	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	428	458	1	1009	Chain	ID=PRO_0000030722;Note=Helicase-like transcription factor
HLTF	Q14527	428	458	435	606	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
HLTF	Q14527	428	458	435	606	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
HLTF	Q14527	428	458	435	606	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
HLTF	Q14527	932	959	837	996	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
HLTF	Q14527	932	959	837	996	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
HLTF	Q14527	932	959	837	996	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
HLTF	Q14527	932	959	925	1009	Region	Note=Interaction with SP1 and SP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391891;Dbxref=PMID:10391891
HLTF	Q14527	932	959	925	1009	Region	Note=Interaction with SP1 and SP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391891;Dbxref=PMID:10391891
HLTF	Q14527	932	959	925	1009	Region	Note=Interaction with SP1 and SP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391891;Dbxref=PMID:10391891
HLTF	Q14527	428	458	429	429	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HLTF	Q14527	428	458	429	429	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HLTF	Q14527	428	458	429	429	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HOOK3	Q86VS8	72	89	1	718	Chain	ID=PRO_0000219197;Note=Protein Hook homolog 3
HOOK3	Q86VS8	156	177	1	718	Chain	ID=PRO_0000219197;Note=Protein Hook homolog 3
HOOK3	Q86VS8	464	510	1	718	Chain	ID=PRO_0000219197;Note=Protein Hook homolog 3
HOOK3	Q86VS8	72	89	10	126	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
HOOK3	Q86VS8	72	89	1	164	Region	Note=Sufficient for interaction with microtubules
HOOK3	Q86VS8	156	177	1	164	Region	Note=Sufficient for interaction with microtubules
HOOK3	Q86VS8	156	177	167	433	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HOOK3	Q86VS8	464	510	462	667	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HOOK3	Q86VS8	72	89	69	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9H
HOOK3	Q86VS8	156	177	144	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9H
HSDL1	Q3SXM5	222	298	2	330	Chain	ID=PRO_0000313671;Note=Inactive hydroxysteroid dehydrogenase-like protein 1
HSDL1	Q3SXM5	222	298	222	222	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSDL1	Q3SXM5	222	298	248	248	Natural variant	ID=VAR_037693;Note=P->S;Dbxref=dbSNP:rs11540436
HSDL1	Q3SXM5	222	298	222	222	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSDL1	Q3SXM5	222	298	222	222	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSDL2	Q6YN16	60	93	1	418	Chain	ID=PRO_0000319888;Note=Hydroxysteroid dehydrogenase-like protein 2
HSDL2	Q6YN16	166	199	1	418	Chain	ID=PRO_0000319888;Note=Hydroxysteroid dehydrogenase-like protein 2
HSDL2	Q6YN16	199	264	1	418	Chain	ID=PRO_0000319888;Note=Hydroxysteroid dehydrogenase-like protein 2
HSDL2	Q6YN16	288	338	1	418	Chain	ID=PRO_0000319888;Note=Hydroxysteroid dehydrogenase-like protein 2
HSDL2	Q6YN16	288	338	306	415	Domain	Note=SCP2
HSDL2	Q6YN16	166	199	168	168	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
HSDL2	Q6YN16	60	93	74	74	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.11
HSDL2	Q6YN16	166	199	172	172	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.11
HSDL2	Q6YN16	288	338	318	318	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TPA8
HSDL2	Q6YN16	166	199	94	166	Alternative sequence	ID=VSP_031529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
HSDL2	Q6YN16	60	93	62	62	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSDL2	Q6YN16	60	93	89	89	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSDL2	Q6YN16	60	93	54	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	60	93	67	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	60	93	78	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	166	199	166	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	166	199	186	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	166	199	191	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	204	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	215	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	242	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	245	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	257	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSDL2	Q6YN16	199	264	261	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KVO
HSF2	Q03933	392	410	1	536	Chain	ID=PRO_0000124569;Note=Heat shock factor protein 2
HSF2	Q03933	392	410	393	410	Alternative sequence	ID=VSP_041128;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MATN1	P21941	221	263	23	496	Chain	ID=PRO_0000007495;Note=Cartilage matrix protein
MATN1	P21941	221	263	23	222	Domain	Note=VWFA 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
MATN1	P21941	221	263	223	263	Domain	Note=EGF-like
MATN1	P21941	221	263	35	221	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
MATN1	P21941	221	263	227	238	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MATN1	P21941	221	263	234	247	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MATN1	P21941	221	263	249	262	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
MATR3	P43243	325	338	2	847	Chain	ID=PRO_0000081622;Note=Matrin-3
MATR3	P43243	394	436	2	847	Chain	ID=PRO_0000081622;Note=Matrin-3
MATR3	P43243	436	478	2	847	Chain	ID=PRO_0000081622;Note=Matrin-3
MATR3	P43243	478	534	2	847	Chain	ID=PRO_0000081622;Note=Matrin-3
MATR3	P43243	394	436	398	473	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
MATR3	P43243	436	478	398	473	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
MATR3	P43243	478	534	496	571	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
MATR3	P43243	478	534	509	509	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MATR3	P43243	478	534	511	511	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MATR3	P43243	478	534	522	522	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MATR3	P43243	478	534	533	533	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
MATR3	P43243	436	478	478	478	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MATR3	P43243	478	534	478	478	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MATR3	P43243	478	534	487	487	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
MATR3	P43243	478	534	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
MATR3	P43243	478	534	515	515	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MATR3	P43243	478	534	522	522	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBCK1	Q9BYM8	343	403	1	510	Chain	ID=PRO_0000056295;Note=RanBP-type and C3HC4-type zinc finger-containing protein 1
RBCK1	Q9BYM8	343	403	362	411	Zinc finger	Note=IBR-type
RBCK1	Q9BYM8	343	403	273	510	Alternative sequence	ID=VSP_005768;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBCK1	Q9BYM8	343	403	387	387	Natural variant	ID=VAR_071386;Note=In PGBM1. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23798481;Dbxref=dbSNP:rs566912235,PMID:23798481
MNAT1	P51948	30	80	1	309	Chain	ID=PRO_0000055932;Note=CDK-activating kinase assembly factor MAT1
MNAT1	P51948	187	229	1	309	Chain	ID=PRO_0000055932;Note=CDK-activating kinase assembly factor MAT1
MNAT1	P51948	30	80	6	50	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
MNAT1	P51948	30	80	51	51	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
MNAT1	P51948	187	229	188	229	Alternative sequence	ID=VSP_046772;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MNAT1	P51948	30	80	32	40	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G25
MNAT1	P51948	30	80	43	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G25
MNAT1	P51948	30	80	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G25
MNAT1	P51948	30	80	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G25
HSF4	Q9ULV5	285	360	1	492	Chain	ID=PRO_0000124571;Note=Heat shock factor protein 4
HSF4	Q9ULV5	285	360	245	322	Region	Note=Interactions with DUSP26%2C MAPK1 and MAPK2
HSF4	Q9ULV5	285	360	298	298	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16371476;Dbxref=PMID:16371476
HSF4	Q9ULV5	285	360	293	293	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16371476;Dbxref=PMID:16371476
HSF4	Q9ULV5	285	360	245	319	Alternative sequence	ID=VSP_002418;Note=In isoform HSF4A. LPETNLGLSPHRARGPIISDIPEDSPSPEGTRLSPSSDGRREKGLALLKEEPASPGGDGEAGLALAPNECDFCVT->STYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8972228;Dbxref=PMID:8972228
HSF4	Q9ULV5	285	360	293	293	Mutagenesis	Note=Abolishes sumoylation. 10-fold increased in transactivational activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16371476;Dbxref=PMID:16371476
HSF4	Q9ULV5	285	360	298	298	Mutagenesis	Note=Abolishes phosphorylation. Greatly reduced sumoylation. Greatly increased transactivational activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16371476;Dbxref=PMID:16371476
MATN3	O15232	263	305	29	486	Chain	ID=PRO_0000007657;Note=Matrilin-3
MATN3	O15232	263	305	264	305	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MATN3	O15232	263	305	268	279	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MATN3	O15232	263	305	275	289	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MATN3	O15232	263	305	291	304	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
MATN3	O15232	263	305	266	307	Alternative sequence	ID=VSP_054374;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MATN3	O15232	263	305	303	303	Natural variant	ID=VAR_015852;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12736871,ECO:0000269|PubMed:14729835,ECO:0000269|PubMed:15459972;Dbxref=dbSNP:rs77245812,PMID:12736871,PMID:14729835,PMID:15459972
MATN3	O15232	263	305	304	304	Natural variant	ID=VAR_019888;Note=In SEMD-MATN3. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121775;Dbxref=dbSNP:rs104893639,PMID:15121775
MVB12A	Q96EY5	30	63	1	273	Chain	ID=PRO_0000249069;Note=Multivesicular body subunit 12A
MVB12A	Q96EY5	138	177	1	273	Chain	ID=PRO_0000249069;Note=Multivesicular body subunit 12A
MVB12A	Q96EY5	234	253	1	273	Chain	ID=PRO_0000249069;Note=Multivesicular body subunit 12A
MVB12A	Q96EY5	30	63	1	273	Chain	ID=PRO_0000249069;Note=Multivesicular body subunit 12A
MVB12A	Q96EY5	138	177	1	273	Chain	ID=PRO_0000249069;Note=Multivesicular body subunit 12A
MVB12A	Q96EY5	234	253	1	273	Chain	ID=PRO_0000249069;Note=Multivesicular body subunit 12A
MVB12A	Q96EY5	30	63	9	151	Domain	Note=MABP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00831
MVB12A	Q96EY5	138	177	9	151	Domain	Note=MABP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00831
MVB12A	Q96EY5	30	63	9	151	Domain	Note=MABP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00831
MVB12A	Q96EY5	138	177	9	151	Domain	Note=MABP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00831
MVB12A	Q96EY5	234	253	215	265	Domain	Note=UMA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00830
MVB12A	Q96EY5	234	253	215	265	Domain	Note=UMA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00830
MVB12A	Q96EY5	234	253	192	273	Region	Note=Interaction with TSG101%2C VPS37B and VPS28;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005716;Dbxref=PMID:18005716
MVB12A	Q96EY5	234	253	192	273	Region	Note=Interaction with TSG101%2C VPS37B and VPS28;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005716;Dbxref=PMID:18005716
MVB12A	Q96EY5	138	177	155	160	Motif	Note=SH3-binding
MVB12A	Q96EY5	138	177	155	160	Motif	Note=SH3-binding
MVB12A	Q96EY5	138	177	163	163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005716;Dbxref=PMID:18005716
MVB12A	Q96EY5	138	177	163	163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18005716;Dbxref=PMID:18005716
MVB12A	Q96EY5	138	177	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:18005716;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:18005716
MVB12A	Q96EY5	138	177	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:18005716;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:18005716
MVB12A	Q96EY5	138	177	139	178	Alternative sequence	ID=VSP_020629;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MVB12A	Q96EY5	138	177	139	178	Alternative sequence	ID=VSP_020629;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MVB12A	Q96EY5	234	253	238	253	Alternative sequence	ID=VSP_020630;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MVB12A	Q96EY5	234	253	238	253	Alternative sequence	ID=VSP_020630;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPA13	P48723	193	249	23	471	Chain	ID=PRO_0000013558;Note=Heat shock 70 kDa protein 13
HSPA4	P34932	55	102	1	840	Chain	ID=PRO_0000078262;Note=Heat shock 70 kDa protein 4
HSPA4	P34932	102	143	1	840	Chain	ID=PRO_0000078262;Note=Heat shock 70 kDa protein 4
HSPA4	P34932	520	550	1	840	Chain	ID=PRO_0000078262;Note=Heat shock 70 kDa protein 4
HSPA4	P34932	601	643	1	840	Chain	ID=PRO_0000078262;Note=Heat shock 70 kDa protein 4
HSPA4	P34932	679	719	1	840	Chain	ID=PRO_0000078262;Note=Heat shock 70 kDa protein 4
HSPA4	P34932	55	102	76	76	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163
HSPA4	P34932	55	102	89	89	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
HSPA4	P34932	520	550	538	538	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
HSPA4	P34932	520	550	546	546	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
HSPA4	P34932	679	719	679	679	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HSPA4	P34932	102	143	109	800	Alternative sequence	ID=VSP_056885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
HSPA4	P34932	520	550	109	800	Alternative sequence	ID=VSP_056885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
HSPA4	P34932	601	643	109	800	Alternative sequence	ID=VSP_056885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
HSPA4	P34932	679	719	109	800	Alternative sequence	ID=VSP_056885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
HSPA4	P34932	55	102	94	94	Sequence conflict	Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPA4	P34932	601	643	622	622	Sequence conflict	Note=E->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPB6	O14558	66	107	1	160	Chain	ID=PRO_0000125939;Note=Heat shock protein beta-6
HSPB6	O14558	66	107	55	160	Domain	Note=sHSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00285
HSPB6	O14558	66	107	1	72	Region	Note=Involved in stabilization of the HSPB1:HSBP6 heterodimer;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27717639;Dbxref=PMID:27717639
HSPB6	O14558	66	107	67	67	Mutagenesis	Note=No effect on homodimer-based self-association properties%3B no effect on chaperone activity. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24382496;Dbxref=PMID:24382496
HSPB6	O14558	66	107	64	66	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPB6	O14558	66	107	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JUS
HSPB6	O14558	66	107	74	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JUT
HSPB6	O14558	66	107	85	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JUT
HSPB6	O14558	66	107	88	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JUT
HSPB6	O14558	66	107	96	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JUT
HMGCS2	P54868	228	283	38	508	Chain	ID=PRO_0000013483;Note=Hydroxymethylglutaryl-CoA synthase%2C mitochondrial
HMGCS2	P54868	186	228	38	508	Chain	ID=PRO_0000013483;Note=Hydroxymethylglutaryl-CoA synthase%2C mitochondrial
HMGCS2	P54868	186	228	204	204	Binding site	Note=Substrate
HMGCS2	P54868	228	283	258	258	Binding site	Note=Substrate
HMGCS2	P54868	186	228	221	221	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869
HMGCS2	P54868	228	283	243	243	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869
HMGCS2	P54868	228	283	256	256	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869
HMGCS2	P54868	228	283	256	256	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869
HMGCS2	P54868	228	283	187	228	Alternative sequence	ID=VSP_042892;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMGCS2	P54868	186	228	187	228	Alternative sequence	ID=VSP_042892;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMGCS2	P54868	228	283	229	283	Alternative sequence	ID=VSP_047445;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21952825;Dbxref=PMID:21952825
HMGCS2	P54868	186	228	212	212	Natural variant	ID=VAR_032759;Note=In HMGCS2D. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11479731;Dbxref=dbSNP:rs137852638,PMID:11479731
HMGCS2	P54868	228	283	234	234	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMGCS2	P54868	186	228	189	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCS2	P54868	186	228	206	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCS2	P54868	186	228	210	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCS2	P54868	186	228	223	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCS2	P54868	228	283	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCS2	P54868	228	283	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCS2	P54868	228	283	255	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WYA
HMGCLL1	Q8TB92	129	161	2	370	Chain	ID=PRO_0000334669;Note=3-hydroxymethyl-3-methylglutaryl-CoA lyase%2C cytoplasmic
HMGCLL1	Q8TB92	36	66	2	370	Chain	ID=PRO_0000334669;Note=3-hydroxymethyl-3-methylglutaryl-CoA lyase%2C cytoplasmic
HMGCLL1	Q8TB92	129	161	78	345	Domain	Note=Pyruvate carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01151
HMGCLL1	Q8TB92	36	66	37	66	Alternative sequence	ID=VSP_033752;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
HMGCLL1	Q8TB92	36	66	37	53	Alternative sequence	ID=VSP_038021;Note=In isoform 3. TSLLTNLHCFQPDVSGF->ELQSVMLMLHHGPLRKP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMGCLL1	Q8TB92	129	161	54	370	Alternative sequence	ID=VSP_038022;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMGCLL1	Q8TB92	36	66	54	370	Alternative sequence	ID=VSP_038022;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMGCLL1	Q8TB92	129	161	130	161	Alternative sequence	ID=VSP_044324;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMMR	O75330	75	90	1	724	Chain	ID=PRO_0000084007;Note=Hyaluronan mediated motility receptor
HMMR	O75330	422	460	1	724	Chain	ID=PRO_0000084007;Note=Hyaluronan mediated motility receptor
HMMR	O75330	461	509	1	724	Chain	ID=PRO_0000084007;Note=Hyaluronan mediated motility receptor
HMMR	O75330	461	509	477	477	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HMMR	O75330	75	90	1	90	Alternative sequence	ID=VSP_041266;Note=In isoform 4. MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKE->MTLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMMR	O75330	75	90	75	75	Alternative sequence	ID=VSP_038378;Note=In isoform 3. K->KK;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8890751;Dbxref=PMID:15489334,PMID:8890751
HMMR	O75330	75	90	76	90	Alternative sequence	ID=VSP_004286;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HMMR	O75330	461	509	484	484	Natural variant	ID=VAR_024157;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs299295,PMID:14702039,PMID:15489334
HMGN2	P05204	5	20	2	90	Chain	ID=PRO_0000206697;Note=Non-histone chromosomal protein HMG-17
HMGN2	P05204	20	30	2	90	Chain	ID=PRO_0000206697;Note=Non-histone chromosomal protein HMG-17
HMGN2	P05204	30	47	2	90	Chain	ID=PRO_0000206697;Note=Non-histone chromosomal protein HMG-17
HMGN2	P05204	47	79	2	90	Chain	ID=PRO_0000206697;Note=Non-histone chromosomal protein HMG-17
HMGN2	P05204	20	30	25	25	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10739259;Dbxref=PMID:10739259
HMGN2	P05204	20	30	29	29	Modified residue	Note=ADP-ribosylserine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28190768;Dbxref=PMID:28190768
HMGN2	P05204	20	30	29	29	Modified residue	Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10739259;Dbxref=PMID:10739259
HMGN2	P05204	5	20	7	7	Natural variant	ID=VAR_003716;Note=In variant H17. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2040281;Dbxref=PMID:2040281
HMGN2	P05204	5	20	5	5	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
HMGN2	P05204	20	30	26	27	Sequence conflict	Note=AR->SA;Ontology_term=ECO:0000305;evidence=ECO:0000305
HNRNPLL	Q8WVV9	267	291	1	542	Chain	ID=PRO_0000081609;Note=Heterogeneous nuclear ribonucleoprotein L-like
HNRNPLL	Q8WVV9	267	291	268	282	Alternative sequence	ID=VSP_013286;Note=In isoform 2. DRGKGRQRQAILGEH->GCCWLMLKLLERSPL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
HNRNPLL	Q8WVV9	267	291	268	280	Alternative sequence	ID=VSP_013288;Note=In isoform 3. DRGKGRQRQAILG->GRYFIHFRMYLIC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HNRNPLL	Q8WVV9	267	291	281	542	Alternative sequence	ID=VSP_013289;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HNRNPLL	Q8WVV9	267	291	283	542	Alternative sequence	ID=VSP_013287;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
MAST3	O60307	594	628	1	1309	Chain	ID=PRO_0000086314;Note=Microtubule-associated serine/threonine-protein kinase 3
MAST3	O60307	628	669	1	1309	Chain	ID=PRO_0000086314;Note=Microtubule-associated serine/threonine-protein kinase 3
MAST3	O60307	984	1025	1	1309	Chain	ID=PRO_0000086314;Note=Microtubule-associated serine/threonine-protein kinase 3
MAST3	O60307	594	628	367	640	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAST3	O60307	628	669	367	640	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAST3	O60307	628	669	641	712	Domain	Note=AGC-kinase C-terminal
MAST3	O60307	984	1025	950	1038	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
MAST3	O60307	984	1025	977	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KHF
MAST3	O60307	984	1025	991	995	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KHF
MAST3	O60307	984	1025	1002	1006	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KHF
MAST3	O60307	984	1025	1016	1025	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KHF
HSPH1	Q92598	528	572	2	858	Chain	ID=PRO_0000078284;Note=Heat shock protein 105 kDa
HSPH1	Q92598	102	143	2	858	Chain	ID=PRO_0000078284;Note=Heat shock protein 105 kDa
HSPH1	Q92598	528	572	557	557	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
HSPH1	Q92598	528	572	561	561	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
HSPH1	Q92598	102	143	104	144	Alternative sequence	ID=VSP_035428;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPH1	Q92598	528	572	529	572	Alternative sequence	ID=VSP_002428;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9931472;Dbxref=PMID:9931472
HRG	P04196	213	247	19	525	Chain	ID=PRO_0000006709;Note=Histidine-rich glycoprotein
HRG	P04196	213	247	137	254	Domain	Note=Cystatin 2
HRG	P04196	213	247	24	504	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HRG	P04196	213	247	203	417	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HRG	P04196	213	247	218	241	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HRG	P04196	213	247	241	241	Natural variant	ID=VAR_063001;Note=In THPH11%3B HRG Tokushima 2%3B results in increased intracellular degradation and reduced protein secretion. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11057869;Dbxref=dbSNP:rs2276804,PMID:11057869
HSPA12B	Q96MM6	151	186	1	686	Chain	ID=PRO_0000078294;Note=Heat shock 70 kDa protein 12B
HSPA12B	Q96MM6	186	225	1	686	Chain	ID=PRO_0000078294;Note=Heat shock 70 kDa protein 12B
HSPA4L	O95757	102	143	1	839	Chain	ID=PRO_0000078280;Note=Heat shock 70 kDa protein 4L
HSPA4L	O95757	682	722	1	839	Chain	ID=PRO_0000078280;Note=Heat shock 70 kDa protein 4L
HSPA4L	O95757	102	143	1	839	Chain	ID=PRO_0000078280;Note=Heat shock 70 kDa protein 4L
HSPA4L	O95757	682	722	1	839	Chain	ID=PRO_0000078280;Note=Heat shock 70 kDa protein 4L
MATK	P42679	399	428	1	507	Chain	ID=PRO_0000088073;Note=Megakaryocyte-associated tyrosine-protein kinase
MATK	P42679	225	247	1	507	Chain	ID=PRO_0000088073;Note=Megakaryocyte-associated tyrosine-protein kinase
MATK	P42679	399	428	235	482	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MATK	P42679	225	247	235	482	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MATK	P42679	225	247	241	249	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MATK	P42679	399	428	400	400	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HR	O43593	1071	1126	1	1189	Chain	ID=PRO_0000083890;Note=Lysine-specific demethylase hairless
HR	O43593	1071	1126	946	1157	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
HR	O43593	1071	1126	1125	1125	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
HR	O43593	1071	1126	1072	1126	Alternative sequence	ID=VSP_004276;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9736769;Dbxref=PMID:9736769
HDX	Q7Z353	417	435	1	690	Chain	ID=PRO_0000299487;Note=Highly divergent homeobox
HDX	Q7Z353	417	435	1	690	Chain	ID=PRO_0000299487;Note=Highly divergent homeobox
HDX	Q7Z353	0	49	1	690	Chain	ID=PRO_0000299487;Note=Highly divergent homeobox
HDX	Q7Z353	0	49	3	63	DNA binding	Note=Homeobox 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
HDX	Q7Z353	417	435	435	498	DNA binding	Note=Homeobox 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
HDX	Q7Z353	417	435	435	498	DNA binding	Note=Homeobox 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
HDX	Q7Z353	0	49	1	58	Alternative sequence	ID=VSP_027708;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HEATR4	Q86WZ0	519	573	1	1026	Chain	ID=PRO_0000254129;Note=HEAT repeat-containing protein 4
HEATR4	Q86WZ0	519	573	1	1026	Chain	ID=PRO_0000254129;Note=HEAT repeat-containing protein 4
HEATR4	Q86WZ0	519	573	530	568	Repeat	Note=HEAT 1
HEATR4	Q86WZ0	519	573	530	568	Repeat	Note=HEAT 1
HMG20B	Q9P0W2	197	269	1	317	Chain	ID=PRO_0000048575;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
HMG20B	Q9P0W2	197	269	190	257	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HMG20B	Q9P0W2	197	269	223	223	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
HCFC1R1	Q9NWW0	51	93	1	138	Chain	ID=PRO_0000338978;Note=Host cell factor C1 regulator 1
HCFC1R1	Q9NWW0	51	93	1	138	Chain	ID=PRO_0000338978;Note=Host cell factor C1 regulator 1
HCFC1R1	Q9NWW0	32	50	1	138	Chain	ID=PRO_0000338978;Note=Host cell factor C1 regulator 1
HCFC1R1	Q9NWW0	51	93	76	79	Region	Note=Interaction with HCFC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12235138;Dbxref=PMID:12235138
HCFC1R1	Q9NWW0	51	93	76	79	Region	Note=Interaction with HCFC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12235138;Dbxref=PMID:12235138
HCFC1R1	Q9NWW0	51	93	32	51	Alternative sequence	ID=VSP_034082;Note=In isoform 2. SSPLRGAVPMSTKRRLEEEQ->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12235138,ECO:0000303|PubMed:15489334;Dbxref=PMID:12235138,PMID:15489334
HCFC1R1	Q9NWW0	51	93	32	51	Alternative sequence	ID=VSP_034082;Note=In isoform 2. SSPLRGAVPMSTKRRLEEEQ->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12235138,ECO:0000303|PubMed:15489334;Dbxref=PMID:12235138,PMID:15489334
HCFC1R1	Q9NWW0	32	50	32	51	Alternative sequence	ID=VSP_034082;Note=In isoform 2. SSPLRGAVPMSTKRRLEEEQ->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12235138,ECO:0000303|PubMed:15489334;Dbxref=PMID:12235138,PMID:15489334
HCFC1R1	Q9NWW0	51	93	92	92	Natural variant	ID=VAR_043849;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs10508,PMID:15489334
HCFC1R1	Q9NWW0	51	93	92	92	Natural variant	ID=VAR_043849;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs10508,PMID:15489334
HCFC1R1	Q9NWW0	51	93	76	79	Mutagenesis	Note=Loss of interaction with HCFC1. DHPY->AAPA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12235138;Dbxref=PMID:12235138
HCFC1R1	Q9NWW0	51	93	76	79	Mutagenesis	Note=Loss of interaction with HCFC1. DHPY->AAPA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12235138;Dbxref=PMID:12235138
HAPLN2	Q9GZV7	28	146	27	340	Chain	ID=PRO_0000013187;Note=Hyaluronan and proteoglycan link protein 2
HAPLN2	Q9GZV7	28	146	34	144	Domain	Note=Ig-like V-type
HAPLN2	Q9GZV7	28	146	57	128	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HINT2	Q9BX68	74	109	18	163	Chain	ID=PRO_0000109786;Note=Histidine triad nucleotide-binding protein 2%2C mitochondrial
HINT2	Q9BX68	74	109	55	163	Domain	Note=HIT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00464
HINT2	Q9BX68	74	109	80	80	Binding site	Note=Purine nucleotide phosphoramidate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4INI,ECO:0000269|PubMed:23659632;Dbxref=PMID:23659632
HINT2	Q9BX68	74	109	73	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4INC
HINT2	Q9BX68	74	109	84	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4INC
HINT2	Q9BX68	74	109	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4INC
HINT2	Q9BX68	74	109	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4INC
HINT2	Q9BX68	74	109	108	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4INC
HGS	O14964	280	312	1	777	Chain	ID=PRO_0000098708;Note=Hepatocyte growth factor-regulated tyrosine kinase substrate
HGS	O14964	373	393	1	777	Chain	ID=PRO_0000098708;Note=Hepatocyte growth factor-regulated tyrosine kinase substrate
HGS	O14964	280	312	225	543	Region	Note=Interaction with SNX1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HGS	O14964	373	393	225	543	Region	Note=Interaction with SNX1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HGS	O14964	373	393	346	394	Compositional bias	Note=Pro-rich
HGS	O14964	280	312	308	308	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LI8
HMBOX1	Q6NT76	311	343	1	420	Chain	ID=PRO_0000233287;Note=Homeobox-containing protein 1
HMBOX1	Q6NT76	311	343	1	420	Chain	ID=PRO_0000233287;Note=Homeobox-containing protein 1
HMBOX1	Q6NT76	311	343	267	341	DNA binding	Note=Homeobox;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00108,ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	267	341	DNA binding	Note=Homeobox;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00108,ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	335	335	Site	Note=Critical for recognition and binding of 5'-TTAGGG-3' motifs in telomeric DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	335	335	Site	Note=Critical for recognition and binding of 5'-TTAGGG-3' motifs in telomeric DNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	305	420	Alternative sequence	ID=VSP_038984;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19757162;Dbxref=PMID:19757162
HMBOX1	Q6NT76	311	343	305	420	Alternative sequence	ID=VSP_038984;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19757162;Dbxref=PMID:19757162
HMBOX1	Q6NT76	311	343	325	325	Mutagenesis	Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	325	325	Mutagenesis	Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	327	327	Mutagenesis	Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	327	327	Mutagenesis	Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	334	334	Mutagenesis	Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	334	334	Mutagenesis	Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	335	335	Mutagenesis	Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. Confers binding to the non-telomeric 5'-GTGAGT-3' motif. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	335	335	Mutagenesis	Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. Confers binding to the non-telomeric 5'-GTGAGT-3' motif. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	338	338	Mutagenesis	Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	338	338	Mutagenesis	Note=Impairs binding to telomeric 5'-TTAGGG-3' motif. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	339	339	Mutagenesis	Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	339	339	Mutagenesis	Note=Abolishes binding to telomeric 5'-TTAGGG-3' motif. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23685356;Dbxref=PMID:23685356
HMBOX1	Q6NT76	311	343	317	319	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J19
HMBOX1	Q6NT76	311	343	317	319	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J19
HMBOX1	Q6NT76	311	343	323	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J19
HMBOX1	Q6NT76	311	343	323	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J19
HOMER2	Q9NSB8	54	98	1	354	Chain	ID=PRO_0000191008;Note=Homer protein homolog 2
HOMER2	Q9NSB8	54	98	1	110	Domain	Note=WH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00410
HOMER2	Q9NSB8	54	98	92	122	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
HAPLN3	Q96S86	164	265	18	360	Chain	ID=PRO_0000013190;Note=Hyaluronan and proteoglycan link protein 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
HAPLN3	Q96S86	164	265	48	164	Domain	Note=Ig-like V-type;Ontology_term=ECO:0000305;evidence=ECO:0000305
HAPLN3	Q96S86	164	265	166	261	Domain	Note=Link 1;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00323,ECO:0000305
HAPLN3	Q96S86	164	265	188	259	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03994
HAPLN3	Q96S86	164	265	212	233	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03994
HPRT1	P00492	106	128	2	218	Chain	ID=PRO_0000139585;Note=Hypoxanthine-guanine phosphoribosyltransferase
HPRT1	P00492	106	128	115	115	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
HPRT1	P00492	106	128	115	115	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HPRT1	P00492	106	128	107	110	Natural variant	ID=VAR_071617;Note=In LNS%3B Asia. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15571223;Dbxref=PMID:15571223
HPRT1	P00492	106	128	110	110	Natural variant	ID=VAR_006779;Note=In GOUT-HPRT%3B London. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:3198771,ECO:0000269|PubMed:6572373;Dbxref=dbSNP:rs137852482,PMID:3198771,PMID:6572373
HPRT1	P00492	106	128	124	124	Natural variant	ID=VAR_071618;Note=In GOUT-HPRT%3B Asia. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17027311;Dbxref=PMID:17027311
HPRT1	P00492	106	128	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D6N
HPRT1	P00492	106	128	115	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BNJ
HPRT1	P00492	106	128	119	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RAC
HPRT1	P00492	106	128	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HIA
HPRT1	P00492	106	128	128	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HIA
HPSE	Q9Y251	166	224	158	543	Chain	ID=PRO_0000042262;Note=Heparanase 50 kDa subunit
HPSE	Q9Y251	166	224	158	543	Chain	ID=PRO_0000042262;Note=Heparanase 50 kDa subunit
HPSE	Q9Y251	166	224	178	178	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	178	178	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	200	200	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5E8M,ECO:0000244|PDB:5E97,ECO:0000244|PDB:5E98,ECO:0000244|PDB:5E9B,ECO:0000244|PDB:5E9C,ECO:0000269|PubMed:14573609,ECO:0000269|PubMed:28581485;Dbxref=PMID:14573609,PMID:28581485
HPSE	Q9Y251	166	224	200	200	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5E8M,ECO:0000244|PDB:5E97,ECO:0000244|PDB:5E98,ECO:0000244|PDB:5E9B,ECO:0000244|PDB:5E9C,ECO:0000269|PubMed:14573609,ECO:0000269|PubMed:28581485;Dbxref=PMID:14573609,PMID:28581485
HPSE	Q9Y251	166	224	217	217	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5E8M,ECO:0000269|PubMed:14573609,ECO:0000269|PubMed:16263699,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:28581485;Dbxref=PMID:14573609,PMID:16263699,PMID:19159218,PMID:28581485
HPSE	Q9Y251	166	224	217	217	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5E8M,ECO:0000269|PubMed:14573609,ECO:0000269|PubMed:16263699,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:28581485;Dbxref=PMID:14573609,PMID:16263699,PMID:19159218,PMID:28581485
HPSE	Q9Y251	166	224	127	179	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LA4,ECO:0000244|PDB:5LA7,ECO:0000269|PubMed:15334672;Dbxref=PMID:15334672
HPSE	Q9Y251	166	224	127	179	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5LA4,ECO:0000244|PDB:5LA7,ECO:0000269|PubMed:15334672;Dbxref=PMID:15334672
HPSE	Q9Y251	166	224	167	225	Alternative sequence	ID=VSP_044537;Note=In isoform 2. RSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17208203;Dbxref=PMID:17208203
HPSE	Q9Y251	166	224	167	225	Alternative sequence	ID=VSP_044537;Note=In isoform 2. RSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17208203;Dbxref=PMID:17208203
HPSE	Q9Y251	166	224	178	178	Mutagenesis	Note=Faster electrophoretic migration typical of a size reduction and important decrease of secretion. Larger size reduction%3B when associated with Q-162%3B Q-200%3B Q-217%3B Q-238 and Q-459. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	178	178	Mutagenesis	Note=Faster electrophoretic migration typical of a size reduction and important decrease of secretion. Larger size reduction%3B when associated with Q-162%3B Q-200%3B Q-217%3B Q-238 and Q-459. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	200	200	Mutagenesis	Note=Faster electrophoretic migration typical of a size reduction and partial decrease in secretion. Larger size reduction%3B when associated with Q-162%3B Q-178%3B Q-217%3B Q-238 and Q-459. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	200	200	Mutagenesis	Note=Faster electrophoretic migration typical of a size reduction and partial decrease in secretion. Larger size reduction%3B when associated with Q-162%3B Q-178%3B Q-217%3B Q-238 and Q-459. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	217	217	Mutagenesis	Note=Faster electrophoretic migration typical of a size reduction and partial decrease in secretion. Larger size reduction%3B when associated with Q-162%3B Q-178%3B Q-200%3B Q-238 and Q-459. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	217	217	Mutagenesis	Note=Faster electrophoretic migration typical of a size reduction and partial decrease in secretion. Larger size reduction%3B when associated with Q-162%3B Q-178%3B Q-200%3B Q-238 and Q-459. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14573609;Dbxref=PMID:14573609
HPSE	Q9Y251	166	224	167	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	167	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	182	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	182	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	202	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	202	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	219	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HPSE	Q9Y251	166	224	219	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L9Z
HSD17B10	Q99714	64	119	2	261	Chain	ID=PRO_0000054810;Note=3-hydroxyacyl-CoA dehydrogenase type-2
HSD17B10	Q99714	9	64	2	261	Chain	ID=PRO_0000054810;Note=3-hydroxyacyl-CoA dehydrogenase type-2
HSD17B10	Q99714	9	64	12	41	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15342248;Dbxref=PMID:15342248
HSD17B10	Q99714	9	64	53	53	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08756
HSD17B10	Q99714	9	64	53	53	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08756
HSD17B10	Q99714	64	119	69	69	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08756
HSD17B10	Q99714	64	119	99	99	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08756
HSD17B10	Q99714	64	119	105	105	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08756
HSD17B10	Q99714	9	64	12	12	Natural variant	ID=VAR_080049;Note=In HSD10MD%3B decreased dehydrogenase activity%3B decreased tRNA methylation%3B decreased mitochondrial tRNA 5'-end processing. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28888424;Dbxref=PMID:28888424
HSD17B10	Q99714	64	119	65	65	Natural variant	ID=VAR_078863;Note=In HSD10MD%3B unknown pathological significance. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22132097;Dbxref=dbSNP:rs104886492,PMID:22132097
HSD17B10	Q99714	64	119	86	86	Natural variant	ID=VAR_078864;Note=In HSD10MD%3B decreased 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity%3B no effect on NAD+ binding. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20077426;Dbxref=dbSNP:rs587777651,PMID:20077426
HSD17B10	Q99714	9	64	20	20	Mutagenesis	Note=Decreased dehydrogenase activity. Does not affect mitochondrial tRNA 5'-end processing. Does not affect tRNA methylation. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23042678,ECO:0000269|PubMed:25925575;Dbxref=PMID:23042678,PMID:25925575
HSD17B10	Q99714	9	64	12	16	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	9	64	17	19	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	9	64	21	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	9	64	36	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	9	64	47	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	9	64	58	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	64	119	68	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	64	119	87	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	64	119	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	64	119	103	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HSD17B10	Q99714	64	119	111	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O23
HFM1	A2PYH4	893	937	1	1435	Chain	ID=PRO_0000324393;Note=Probable ATP-dependent DNA helicase HFM1
HFM1	A2PYH4	751	778	1	1435	Chain	ID=PRO_0000324393;Note=Probable ATP-dependent DNA helicase HFM1
HFM1	A2PYH4	893	937	777	1092	Domain	Note=SEC63
HFM1	A2PYH4	751	778	777	1092	Domain	Note=SEC63
HFM1	A2PYH4	751	778	1	768	Alternative sequence	ID=VSP_032249;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HHEX	Q03014	180	197	1	270	Chain	ID=PRO_0000049074;Note=Hematopoietically-expressed homeobox protein HHEX
HHEX	Q03014	180	197	137	196	DNA binding	Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
HHEX	Q03014	180	197	178	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1O
HMOX1	P09601	48	212	1	288	Chain	ID=PRO_0000209687;Note=Heme oxygenase 1
HMOX1	P09601	48	212	134	134	Binding site	Note=Heme
HMOX1	P09601	48	212	183	183	Binding site	Note=Heme
HMOX1	P09601	48	212	106	106	Natural variant	ID=VAR_022156;Note=P->L;Dbxref=dbSNP:rs9282702
HMOX1	P09601	48	212	140	140	Mutagenesis	Note=Inactive as a heme oxygenase but active as a peroxidase. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12842469;Dbxref=PMID:12842469
HMOX1	P09601	48	212	44	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	72	74	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	75	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	80	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	86	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	101	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	109	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	126	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	129	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZY
HMOX1	P09601	48	212	165	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	175	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMOX1	P09601	48	212	193	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N45
HMGN1	P05114	26	42	1	100	Chain	ID=PRO_0000206691;Note=Non-histone chromosomal protein HMG-14
HMGN1	P05114	16	26	1	100	Chain	ID=PRO_0000206691;Note=Non-histone chromosomal protein HMG-14
HMGN1	P05114	5	16	1	100	Chain	ID=PRO_0000206691;Note=Non-histone chromosomal protein HMG-14
HMGN1	P05114	5	16	7	7	Modified residue	Note=ADP-ribosylserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28190768;Dbxref=PMID:28190768
HMGN1	P05114	5	16	8	8	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
HMGN1	P05114	5	16	14	14	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HMGN1	P05114	16	26	21	21	Modified residue	Note=Phosphoserine%3B by RPS6KA5;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:10739259;Dbxref=PMID:23186163,PMID:10739259
HMGN1	P05114	16	26	25	25	Modified residue	Note=ADP-ribosylserine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28190768;Dbxref=PMID:28190768
HMGN1	P05114	16	26	25	25	Modified residue	Note=Phosphoserine%3B alternate%3B by RPS6KA5;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:10739259;Dbxref=PMID:23186163,PMID:10739259
HMGN1	P05114	26	42	27	27	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18608
HOMER3	Q9NSC5	101	137	1	361	Chain	ID=PRO_0000191011;Note=Homer protein homolog 3
HOMER3	Q9NSC5	101	137	1	361	Chain	ID=PRO_0000191011;Note=Homer protein homolog 3
HOMER3	Q9NSC5	101	137	1	361	Chain	ID=PRO_0000191011;Note=Homer protein homolog 3
HOMER3	Q9NSC5	101	137	1	113	Domain	Note=WH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00410
HOMER3	Q9NSC5	101	137	1	113	Domain	Note=WH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00410
HOMER3	Q9NSC5	101	137	1	113	Domain	Note=WH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00410
HOMER3	Q9NSC5	101	137	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2X5
HOMER3	Q9NSC5	101	137	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2X5
HOMER3	Q9NSC5	101	137	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2X5
HOMER3	Q9NSC5	101	137	101	136	Alternative sequence	ID=VSP_045715;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	101	136	Alternative sequence	ID=VSP_045715;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	101	136	Alternative sequence	ID=VSP_045715;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	118	121	Alternative sequence	ID=VSP_009073;Note=In isoform 4. EKSQ->QLQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	118	121	Alternative sequence	ID=VSP_009073;Note=In isoform 4. EKSQ->QLQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	118	121	Alternative sequence	ID=VSP_009073;Note=In isoform 4. EKSQ->QLQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	122	361	Alternative sequence	ID=VSP_009074;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	122	361	Alternative sequence	ID=VSP_009074;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	122	361	Alternative sequence	ID=VSP_009074;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	124	145	Alternative sequence	ID=VSP_009075;Note=In isoform 3. GELTSPALGLASHQVPPSPLVS->WGGPQSALVVGSFGAVFELLIV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	124	145	Alternative sequence	ID=VSP_009075;Note=In isoform 3. GELTSPALGLASHQVPPSPLVS->WGGPQSALVVGSFGAVFELLIV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	124	145	Alternative sequence	ID=VSP_009075;Note=In isoform 3. GELTSPALGLASHQVPPSPLVS->WGGPQSALVVGSFGAVFELLIV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10653696;Dbxref=PMID:10653696
HOMER3	Q9NSC5	101	137	96	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8V
HOMER3	Q9NSC5	101	137	96	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8V
HOMER3	Q9NSC5	101	137	96	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P8V
HSPBP1	Q9NZL4	213	265	1	359	Chain	ID=PRO_0000084035;Note=Hsp70-binding protein 1
HSPBP1	Q9NZL4	138	213	1	359	Chain	ID=PRO_0000084035;Note=Hsp70-binding protein 1
HSPBP1	Q9NZL4	213	265	1	359	Chain	ID=PRO_0000084035;Note=Hsp70-binding protein 1
HSPBP1	Q9NZL4	138	213	1	359	Chain	ID=PRO_0000084035;Note=Hsp70-binding protein 1
HSPBP1	Q9NZL4	213	265	1	359	Chain	ID=PRO_0000084035;Note=Hsp70-binding protein 1
HSPBP1	Q9NZL4	138	213	1	359	Chain	ID=PRO_0000084035;Note=Hsp70-binding protein 1
HSPBP1	Q9NZL4	138	213	132	174	Repeat	Note=ARM 1
HSPBP1	Q9NZL4	138	213	132	174	Repeat	Note=ARM 1
HSPBP1	Q9NZL4	138	213	132	174	Repeat	Note=ARM 1
HSPBP1	Q9NZL4	213	265	177	217	Repeat	Note=ARM 2
HSPBP1	Q9NZL4	138	213	177	217	Repeat	Note=ARM 2
HSPBP1	Q9NZL4	213	265	177	217	Repeat	Note=ARM 2
HSPBP1	Q9NZL4	138	213	177	217	Repeat	Note=ARM 2
HSPBP1	Q9NZL4	213	265	177	217	Repeat	Note=ARM 2
HSPBP1	Q9NZL4	138	213	177	217	Repeat	Note=ARM 2
HSPBP1	Q9NZL4	213	265	220	259	Repeat	Note=ARM 3
HSPBP1	Q9NZL4	213	265	220	259	Repeat	Note=ARM 3
HSPBP1	Q9NZL4	213	265	220	259	Repeat	Note=ARM 3
HSPBP1	Q9NZL4	213	265	262	301	Repeat	Note=ARM 4
HSPBP1	Q9NZL4	213	265	262	301	Repeat	Note=ARM 4
HSPBP1	Q9NZL4	213	265	262	301	Repeat	Note=ARM 4
HSPBP1	Q9NZL4	213	265	204	306	Alternative sequence	ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBP1	Q9NZL4	138	213	204	306	Alternative sequence	ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBP1	Q9NZL4	213	265	204	306	Alternative sequence	ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBP1	Q9NZL4	138	213	204	306	Alternative sequence	ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBP1	Q9NZL4	213	265	204	306	Alternative sequence	ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBP1	Q9NZL4	138	213	204	306	Alternative sequence	ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPBP1	Q9NZL4	138	213	134	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	134	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	134	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	145	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	145	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	145	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	152	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	152	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	152	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	159	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	159	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	159	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	177	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	177	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	177	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	188	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	188	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	188	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	202	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	202	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	202	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	202	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	202	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	138	213	202	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	220	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	220	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	220	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	231	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	231	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	231	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	244	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	244	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	244	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	265	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	265	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
HSPBP1	Q9NZL4	213	265	265	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR
ABCA5	Q8WWZ7	1472	1511	1	1642	Chain	ID=PRO_0000250669;Note=ATP-binding cassette sub-family A member 5
ABCA5	Q8WWZ7	1010	1048	1	1642	Chain	ID=PRO_0000250669;Note=ATP-binding cassette sub-family A member 5
ABCA5	Q8WWZ7	757	797	1	1642	Chain	ID=PRO_0000250669;Note=ATP-binding cassette sub-family A member 5
ABCA5	Q8WWZ7	1472	1511	1	1642	Chain	ID=PRO_0000250669;Note=ATP-binding cassette sub-family A member 5
ABCA5	Q8WWZ7	1010	1048	1	1642	Chain	ID=PRO_0000250669;Note=ATP-binding cassette sub-family A member 5
ABCA5	Q8WWZ7	757	797	1	1642	Chain	ID=PRO_0000250669;Note=ATP-binding cassette sub-family A member 5
ABCA5	Q8WWZ7	1010	1048	1021	1041	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA5	Q8WWZ7	1010	1048	1021	1041	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA5	Q8WWZ7	1472	1511	1290	1533	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA5	Q8WWZ7	1472	1511	1290	1533	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA5	Q8WWZ7	757	797	1	777	Alternative sequence	ID=VSP_020690;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCA5	Q8WWZ7	757	797	1	777	Alternative sequence	ID=VSP_020690;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCA5	Q8WWZ7	1472	1511	926	1642	Alternative sequence	ID=VSP_020692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12504089;Dbxref=PMID:12504089
ABCA5	Q8WWZ7	1010	1048	926	1642	Alternative sequence	ID=VSP_020692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12504089;Dbxref=PMID:12504089
ABCA5	Q8WWZ7	1472	1511	926	1642	Alternative sequence	ID=VSP_020692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12504089;Dbxref=PMID:12504089
ABCA5	Q8WWZ7	1010	1048	926	1642	Alternative sequence	ID=VSP_020692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12504089;Dbxref=PMID:12504089
ABHD17A	Q96GS6	176	235	1	310	Chain	ID=PRO_0000297509;Note=Alpha/beta hydrolase domain-containing protein 17A
ABHD17A	Q96GS6	176	235	190	190	Active site	Note=Charge relay system;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26701913;Dbxref=PMID:26701913
ABHD17A	Q96GS6	176	235	177	310	Alternative sequence	ID=VSP_027271;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABHD17A	Q96GS6	176	235	190	190	Mutagenesis	Note=Loss of catalytic activity. No effect on its localization. No effect on NRAS plasma membrane localization. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26701913;Dbxref=PMID:26701913
DRG2	P55039	75	105	1	364	Chain	ID=PRO_0000205427;Note=Developmentally-regulated GTP-binding protein 2
DRG2	P55039	318	336	1	364	Chain	ID=PRO_0000205427;Note=Developmentally-regulated GTP-binding protein 2
DRG2	P55039	75	105	63	288	Domain	Note=OBG-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
DRG2	P55039	75	105	69	76	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
EBNA1BP2	Q99848	149	179	1	306	Chain	ID=PRO_0000119993;Note=Probable rRNA-processing protein EBP2
EBNA1BP2	Q99848	22	50	1	306	Chain	ID=PRO_0000119993;Note=Probable rRNA-processing protein EBP2
EBNA1BP2	Q99848	149	179	138	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EBNA1BP2	Q99848	149	179	179	179	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ECEL1	O95672	685	717	1	775	Chain	ID=PRO_0000078224;Note=Endothelin-converting enzyme-like 1
ECEL1	O95672	663	685	1	775	Chain	ID=PRO_0000078224;Note=Endothelin-converting enzyme-like 1
ECEL1	O95672	685	717	83	775	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ECEL1	O95672	663	685	83	775	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ECEL1	O95672	663	685	672	672	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
ECEL1	O95672	663	685	679	679	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ECHDC3	Q96DC8	130	197	18	303	Chain	ID=PRO_0000333215;Note=Enoyl-CoA hydratase domain-containing protein 3%2C mitochondrial
ECHDC3	Q96DC8	130	197	1	131	Alternative sequence	ID=VSP_033491;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
ECHDC3	Q96DC8	130	197	151	151	Natural variant	ID=VAR_043127;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15498874,ECO:0000269|Ref.3,ECO:0000269|Ref.5;Dbxref=dbSNP:rs7910140,PMID:14702039,PMID:15489334,PMID:15498874
ECHDC3	Q96DC8	130	197	162	162	Natural variant	ID=VAR_043128;Note=D->N;Dbxref=dbSNP:rs35986488
ECHDC3	Q96DC8	130	197	118	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	142	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	153	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	161	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	171	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	176	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	184	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
ECHDC3	Q96DC8	130	197	196	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VX2
EED	O75530	89	120	2	441	Chain	ID=PRO_0000343725;Note=Polycomb protein EED
EED	O75530	89	120	91	134	Repeat	Note=WD 1
EED	O75530	89	120	81	441	Region	Note=Interaction with EZH2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EED	O75530	89	120	97	97	Mutagenesis	Note=Abolishes binding to H3K27me3. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20974918;Dbxref=PMID:20974918
EED	O75530	89	120	83	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U69
EED	O75530	89	120	96	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U69
EED	O75530	89	120	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H17
EED	O75530	89	120	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U5K
EED	O75530	89	120	111	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U69
EED	O75530	89	120	120	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U69
DNAJC2	Q99543	191	217	1	621	Chain	ID=PRO_0000425752;Note=DnaJ homolog subfamily C member 2
DNAJC2	Q99543	191	217	2	621	Chain	ID=PRO_0000071123;Note=DnaJ homolog subfamily C member 2%2C N-terminally processed
DNAJC2	Q99543	191	217	160	250	Region	Note=ZRF1-UBD
DOCK11	Q5JSL3	682	713	1	2073	Chain	ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11
DOCK11	Q5JSL3	1157	1196	1	2073	Chain	ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11
DOCK11	Q5JSL3	1420	1466	1	2073	Chain	ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11
DOCK11	Q5JSL3	1527	1565	1	2073	Chain	ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11
DOCK11	Q5JSL3	682	713	640	818	Domain	Note=DHR-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00983
DOCK4	Q8N1I0	1759	1797	1	1966	Chain	ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4
DOCK4	Q8N1I0	1550	1590	1	1966	Chain	ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4
DOCK4	Q8N1I0	1434	1463	1	1966	Chain	ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4
DOCK4	Q8N1I0	867	912	1	1966	Chain	ID=PRO_0000189990;Note=Dedicator of cytokinesis protein 4
DOCK4	Q8N1I0	1550	1590	1190	1596	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DOCK4	Q8N1I0	1434	1463	1190	1596	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DOCK4	Q8N1I0	1759	1797	1788	1794	Motif	Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
DOCK4	Q8N1I0	1759	1797	1642	1863	Compositional bias	Note=Ser-rich
DOCK4	Q8N1I0	1759	1797	1769	1769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59764
DOCK4	Q8N1I0	1550	1590	1	1687	Alternative sequence	ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOCK4	Q8N1I0	1434	1463	1	1687	Alternative sequence	ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOCK4	Q8N1I0	867	912	1	1687	Alternative sequence	ID=VSP_007701;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOCK4	Q8N1I0	1759	1797	1760	1797	Alternative sequence	ID=VSP_007706;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9872452;Dbxref=PMID:9872452
DOCK4	Q8N1I0	1550	1590	1570	1570	Natural variant	ID=VAR_057519;Note=R->K;Dbxref=dbSNP:rs3757650
DOCK4	Q8N1I0	1550	1590	1580	1580	Natural variant	ID=VAR_057520;Note=F->L;Dbxref=dbSNP:rs3757651
DUSP12	Q9UNI6	115	152	1	340	Chain	ID=PRO_0000094818;Note=Dual specificity protein phosphatase 12
DUSP12	Q9UNI6	115	152	88	160	Domain	Note=Tyrosine-protein phosphatase
DUSP12	Q9UNI6	115	152	116	121	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:4KI9,ECO:0000305|PubMed:24531476;Dbxref=PMID:24531476
DUSP12	Q9UNI6	115	152	115	115	Active site	Note=Phosphocysteine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DUSP12	Q9UNI6	115	152	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KI9
DUSP12	Q9UNI6	115	152	121	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KI9
DUSP12	Q9UNI6	115	152	138	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KI9
DVL1	O14640	351	402	1	695	Chain	ID=PRO_0000145742;Note=Segment polarity protein dishevelled homolog DVL-1
DVL1	O14640	351	402	378	403	Alternative sequence	ID=VSP_024460;Note=In isoform 2. GTSPCSSAVTRTSSSSLTSSVPGAPQ->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9192851;Dbxref=PMID:9192851
DYNC1H1	Q14204	906	956	2	4646	Chain	ID=PRO_0000114627;Note=Cytoplasmic dynein 1 heavy chain 1
DYNC1H1	Q14204	1148	1188	2	4646	Chain	ID=PRO_0000114627;Note=Cytoplasmic dynein 1 heavy chain 1
DYNC1H1	Q14204	2338	2414	2	4646	Chain	ID=PRO_0000114627;Note=Cytoplasmic dynein 1 heavy chain 1
DYNC1H1	Q14204	3636	3685	2	4646	Chain	ID=PRO_0000114627;Note=Cytoplasmic dynein 1 heavy chain 1
DYNC1H1	Q14204	3820	3865	2	4646	Chain	ID=PRO_0000114627;Note=Cytoplasmic dynein 1 heavy chain 1
DYNC1H1	Q14204	906	956	53	1867	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DYNC1H1	Q14204	1148	1188	53	1867	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DYNC1H1	Q14204	2338	2414	2180	2452	Region	Note=AAA 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
DYNC1H1	Q14204	3636	3685	3553	3782	Region	Note=AAA 5;Ontology_term=ECO:0000250;evidence=ECO:0000250
DYNC1H1	Q14204	1148	1188	1171	1252	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DYNC1H1	Q14204	3820	3865	3822	3822	Natural variant	ID=VAR_065085;Note=In MRD13%3B de novo mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21076407;Dbxref=dbSNP:rs387906739,PMID:21076407
DYNC1H1	Q14204	906	956	896	925	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1V
DDX21	Q9NR30	301	363	1	783	Chain	ID=PRO_0000055027;Note=Nucleolar RNA helicase 2
DDX21	Q9NR30	412	462	1	783	Chain	ID=PRO_0000055027;Note=Nucleolar RNA helicase 2
DDX21	Q9NR30	462	516	1	783	Chain	ID=PRO_0000055027;Note=Nucleolar RNA helicase 2
DDX21	Q9NR30	679	694	1	783	Chain	ID=PRO_0000055027;Note=Nucleolar RNA helicase 2
DDX21	Q9NR30	301	363	217	396	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX21	Q9NR30	412	462	429	573	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX21	Q9NR30	462	516	429	573	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX21	Q9NR30	301	363	339	342	Motif	Note=DEAD box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX21	Q9NR30	301	363	339	340	Mutagenesis	Note=In mutant DEV%3B loss of helicase activity. Defects in release of P-TEFb from inhibitory 7SK snRNP. DE->HG;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25470060,ECO:0000269|PubMed:9461305;Dbxref=PMID:25470060,PMID:9461305
DDX21	Q9NR30	679	694	679	686	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M3D
DDX21	Q9NR30	679	694	687	693	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M3D
DECR1	Q16698	246	295	35	335	Chain	ID=PRO_0000031965;Note=2%2C4-dienoyl-CoA reductase%2C mitochondrial
DECR1	Q16698	295	316	35	335	Chain	ID=PRO_0000031965;Note=2%2C4-dienoyl-CoA reductase%2C mitochondrial
DECR1	Q16698	246	295	251	251	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DECR1	Q16698	246	295	260	260	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CQ62
DECR1	Q16698	246	295	260	260	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CQ62
DECR1	Q16698	246	295	287	287	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DECR1	Q16698	246	295	292	292	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
DECR1	Q16698	295	316	303	303	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DECR1	Q16698	295	316	311	311	Sequence conflict	Note=F->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DECR1	Q16698	246	295	254	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W73
DECR1	Q16698	246	295	257	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W6U
DECR1	Q16698	246	295	274	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W6U
DECR1	Q16698	246	295	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W6U
DECR1	Q16698	295	316	296	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W6U
DECR1	Q16698	295	316	303	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W6U
DECR1	Q16698	295	316	312	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W6U
DENND1C	Q8IV53	454	469	1	801	Chain	ID=PRO_0000304676;Note=DENN domain-containing protein 1C
DENND1C	Q8IV53	309	351	1	801	Chain	ID=PRO_0000304676;Note=DENN domain-containing protein 1C
DENND1C	Q8IV53	309	351	182	318	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND1C	Q8IV53	309	351	320	398	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2C	Q68D51	889	918	1	928	Chain	ID=PRO_0000242684;Note=DENN domain-containing protein 2C
DENND2C	Q68D51	761	775	1	928	Chain	ID=PRO_0000242684;Note=DENN domain-containing protein 2C
DENND2C	Q68D51	352	409	1	928	Chain	ID=PRO_0000242684;Note=DENN domain-containing protein 2C
DENND2C	Q68D51	649	663	1	928	Chain	ID=PRO_0000242684;Note=DENN domain-containing protein 2C
DENND2C	Q68D51	352	409	1	928	Chain	ID=PRO_0000242684;Note=DENN domain-containing protein 2C
DENND2C	Q68D51	761	775	663	796	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2C	Q68D51	649	663	663	796	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2C	Q68D51	352	409	354	410	Alternative sequence	ID=VSP_036782;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DENND2C	Q68D51	352	409	354	410	Alternative sequence	ID=VSP_036782;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DENND2C	Q68D51	649	663	642	753	Alternative sequence	ID=VSP_019468;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DENND2C	Q68D51	352	409	392	392	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND2C	Q68D51	352	409	392	392	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND2C	Q68D51	761	775	769	769	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND2C	Q68D51	761	775	774	774	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND2D	Q9H6A0	324	338	1	471	Chain	ID=PRO_0000242686;Note=DENN domain-containing protein 2D
DENND2D	Q9H6A0	142	168	1	471	Chain	ID=PRO_0000242686;Note=DENN domain-containing protein 2D
DENND2D	Q9H6A0	142	168	55	204	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2D	Q9H6A0	324	338	226	359	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND4B	O75064	1110	1151	1	1496	Chain	ID=PRO_0000304678;Note=DENN domain-containing protein 4B
DENND4B	O75064	924	980	1	1496	Chain	ID=PRO_0000304678;Note=DENN domain-containing protein 4B
DENND4B	O75064	813	856	1	1496	Chain	ID=PRO_0000304678;Note=DENN domain-containing protein 4B
DENND4B	O75064	534	606	1	1496	Chain	ID=PRO_0000304678;Note=DENN domain-containing protein 4B
DENND4B	O75064	534	606	528	644	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND4B	O75064	813	856	812	846	Repeat	Note=PPR 2
DENND4B	O75064	1110	1151	1106	1158	Compositional bias	Note=Ser-rich
DENND4B	O75064	924	980	953	953	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HSD17B11	Q8NBQ5	232	270	20	300	Chain	ID=PRO_0000031970;Note=Estradiol 17-beta-dehydrogenase 11
HSD17B11	Q8NBQ5	186	231	20	300	Chain	ID=PRO_0000031970;Note=Estradiol 17-beta-dehydrogenase 11
HSD17B11	Q8NBQ5	106	150	20	300	Chain	ID=PRO_0000031970;Note=Estradiol 17-beta-dehydrogenase 11
HSD17B11	Q8NBQ5	106	150	106	106	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	106	150	107	107	Sequence conflict	Note=V->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	186	231	228	228	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	186	231	229	229	Sequence conflict	Note=P->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	232	270	263	263	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	232	270	264	264	Sequence conflict	Note=A->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	232	270	265	265	Sequence conflict	Note=F->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B11	Q8NBQ5	106	150	97	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	106	150	115	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	106	150	130	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	106	150	133	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	106	150	146	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	186	231	179	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	186	231	211	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	186	231	220	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	232	270	230	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	186	231	230	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	232	270	239	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	232	270	255	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B11	Q8NBQ5	232	270	265	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB1
HSD17B1	P14061	88	148	2	328	Chain	ID=PRO_0000054567;Note=Estradiol 17-beta-dehydrogenase 1
HSD17B1	P14061	88	148	143	143	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8805577;Dbxref=PMID:8805577
HSD17B1	P14061	88	148	86	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JTV
HSD17B1	P14061	88	148	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JTV
HSD17B1	P14061	88	148	105	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JTV
HSD17B1	P14061	88	148	117	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JTV
HSD17B1	P14061	88	148	136	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JTV
HSD17B1	P14061	88	148	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JTV
HSD17B3	P37058	224	274	1	310	Chain	ID=PRO_0000054573;Note=Testosterone 17-beta-dehydrogenase 3
HSD17B3	P37058	202	224	1	310	Chain	ID=PRO_0000054573;Note=Testosterone 17-beta-dehydrogenase 3
HSD17B3	P37058	151	163	1	310	Chain	ID=PRO_0000054573;Note=Testosterone 17-beta-dehydrogenase 3
HSD17B3	P37058	92	128	1	310	Chain	ID=PRO_0000054573;Note=Testosterone 17-beta-dehydrogenase 3
HSD17B3	P37058	224	274	225	274	Alternative sequence	ID=VSP_056640;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
HSD17B3	P37058	202	224	203	203	Natural variant	ID=VAR_006955;Note=In MPH. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8075637;Dbxref=dbSNP:rs119481076,PMID:8075637
HSD17B3	P37058	202	224	205	205	Natural variant	ID=VAR_016071;Note=In MPH. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8550739;Dbxref=dbSNP:rs372027264,PMID:8550739
HSD17B3	P37058	202	224	208	208	Natural variant	ID=VAR_016072;Note=In MPH. F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8550739;Dbxref=PMID:8550739
HSD17B3	P37058	202	224	215	215	Natural variant	ID=VAR_016203;Note=In MPH. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8550739;Dbxref=dbSNP:rs115063639,PMID:8550739
HSD17B3	P37058	224	274	232	232	Natural variant	ID=VAR_006956;Note=In MPH. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8075637;Dbxref=dbSNP:rs28939085,PMID:8075637
HSD17B3	P37058	224	274	235	235	Natural variant	ID=VAR_006957;Note=In MPH. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8075637;Dbxref=dbSNP:rs119481074,PMID:8075637
HSD17B3	P37058	224	274	268	268	Natural variant	ID=VAR_016073;Note=In MPH%3B complete loss of activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11158067;Dbxref=dbSNP:rs119481080,PMID:11158067
HSD17B7	P56937	214	249	1	341	Chain	ID=PRO_0000054586;Note=3-keto-steroid reductase
HSD17B7	P56937	268	301	1	341	Chain	ID=PRO_0000054586;Note=3-keto-steroid reductase
HSD17B7	P56937	214	249	1	229	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD17B7	P56937	214	249	230	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD17B7	P56937	268	301	251	341	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD17B7	P56937	214	249	229	229	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD17B7	P56937	214	249	215	249	Alternative sequence	ID=VSP_012766;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12732193;Dbxref=PMID:12732193
HSD17B7	P56937	268	301	273	276	Sequence conflict	Note=HQKP->PPKA;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B7	P56937	268	301	288	295	Sequence conflict	Note=ATTGFGRN->GTTALEEI;Ontology_term=ECO:0000305;evidence=ECO:0000305
QDPR	P09417	98	145	2	244	Chain	ID=PRO_0000054636;Note=Dihydropteridine reductase
QDPR	P09417	35	66	2	244	Chain	ID=PRO_0000054636;Note=Dihydropteridine reductase
QDPR	P09417	35	66	14	38	Nucleotide binding	Note=NADP
QDPR	P09417	98	145	102	102	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BVI4
QDPR	P09417	35	66	36	66	Alternative sequence	ID=VSP_054356;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
QDPR	P09417	35	66	36	36	Natural variant	ID=VAR_006961;Note=In HPABH4C. W->R;Dbxref=dbSNP:rs104893865
QDPR	P09417	35	66	51	51	Natural variant	ID=VAR_013027;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:3031582,ECO:0000269|PubMed:3033643,ECO:0000269|PubMed:9744478;Dbxref=PMID:3031582,PMID:3033643,PMID:9744478
QDPR	P09417	35	66	66	66	Natural variant	ID=VAR_021769;Note=In HPABH4C%3B severe. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11153907;Dbxref=PMID:11153907
QDPR	P09417	98	145	108	108	Natural variant	ID=VAR_006963;Note=In HPABH4C. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8326489;Dbxref=dbSNP:rs104893864,PMID:8326489
QDPR	P09417	98	145	123	123	Natural variant	ID=VAR_006964;Note=In HPABH4C. T->TT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2116088;Dbxref=PMID:2116088
QDPR	P09417	98	145	145	145	Natural variant	ID=VAR_006965;Note=In HPABH4C. P->L
QDPR	P09417	35	66	36	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
QDPR	P09417	35	66	48	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
QDPR	P09417	35	66	60	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
QDPR	P09417	98	145	100	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
QDPR	P09417	98	145	112	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
QDPR	P09417	98	145	126	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
QDPR	P09417	98	145	138	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDR
DNAJC7	Q99615	410	461	2	494	Chain	ID=PRO_0000071058;Note=DnaJ homolog subfamily C member 7
DNAJC7	Q99615	361	410	2	494	Chain	ID=PRO_0000071058;Note=DnaJ homolog subfamily C member 7
DNAJC7	Q99615	251	306	2	494	Chain	ID=PRO_0000071058;Note=DnaJ homolog subfamily C member 7
DNAJC7	Q99615	135	160	2	494	Chain	ID=PRO_0000071058;Note=DnaJ homolog subfamily C member 7
DNAJC7	Q99615	97	135	2	494	Chain	ID=PRO_0000071058;Note=DnaJ homolog subfamily C member 7
DNAJC7	Q99615	97	135	96	129	Repeat	Note=TPR 3
DNAJC7	Q99615	135	160	142	175	Repeat	Note=TPR 4
DNAJC7	Q99615	251	306	256	289	Repeat	Note=TPR 7
DNAJC7	Q99615	251	306	294	327	Repeat	Note=TPR 8
DNAJC7	Q99615	361	410	328	361	Repeat	Note=TPR 9
DNAJC7	Q99615	410	461	381	451	Domain	Note=J;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00286
DNAJC7	Q99615	361	410	381	451	Domain	Note=J;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00286
DNAJC7	Q99615	361	410	393	393	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DNAJC7	Q99615	97	135	101	101	Mutagenesis	Note=Impairs interaction with HSP90AA1 and HSPA1A/B. Abolishes interaction with HSP90AA1 and HSPA1A/B%3B when associated with A-333 and A-409. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12853476;Dbxref=PMID:12853476
DNAJC7	Q99615	361	410	409	409	Mutagenesis	Note=Predominantly nuclear localization. Abolishes interaction with HSP90AA1 and HSPA1A/B%3B when associated with A-101 and A-333. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11573955,ECO:0000269|PubMed:12853476;Dbxref=PMID:11573955,PMID:12853476
DNAJC7	Q99615	361	410	375	375	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNPH1	O43598	88	125	2	174	Chain	ID=PRO_0000097200;Note=2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DNPH1	O43598	88	125	104	104	Binding site	Note=Substrate;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03036,ECO:0000269|PubMed:25108359;Dbxref=PMID:25108359
DNPH1	O43598	88	125	98	98	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
DNPH1	O43598	88	125	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DNPH1	O43598	88	125	88	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P5E
DNPH1	O43598	88	125	99	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P5E
DNPH1	O43598	88	125	115	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P5E
DNPH1	O43598	88	125	121	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P5E
DPH2	Q9BQC3	161	389	1	489	Chain	ID=PRO_0000307889;Note=2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
DPH2	Q9BQC3	161	389	27	161	Alternative sequence	ID=VSP_056053;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPH2	Q9BQC3	161	389	162	389	Alternative sequence	ID=VSP_047151;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPH2	Q9BQC3	161	389	266	266	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DOCK2	Q92608	461	494	1	1830	Chain	ID=PRO_0000189986;Note=Dedicator of cytokinesis protein 2
DOCK2	Q92608	901	933	1	1830	Chain	ID=PRO_0000189986;Note=Dedicator of cytokinesis protein 2
DOCK2	Q92608	1548	1576	1	1830	Chain	ID=PRO_0000189986;Note=Dedicator of cytokinesis protein 2
DOCK2	Q92608	393	425	1	1830	Chain	ID=PRO_0000189986;Note=Dedicator of cytokinesis protein 2
DOCK2	Q92608	1040	1068	1	1830	Chain	ID=PRO_0000189986;Note=Dedicator of cytokinesis protein 2
DOCK2	Q92608	461	494	423	607	Domain	Note=DHR-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00983
DOCK2	Q92608	393	425	423	607	Domain	Note=DHR-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00983
DOCK2	Q92608	1548	1576	1211	1622	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DOCK2	Q92608	1040	1068	939	1476	Region	Note=Interaction with CRKL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12393632;Dbxref=PMID:12393632
DOCK2	Q92608	393	425	1	449	Alternative sequence	ID=VSP_007696;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DOCK2	Q92608	461	494	462	494	Alternative sequence	ID=VSP_007697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DOCK2	Q92608	1548	1576	956	1830	Alternative sequence	ID=VSP_007700;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DOCK2	Q92608	1040	1068	956	1830	Alternative sequence	ID=VSP_007700;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DOCK2	Q92608	1548	1576	1558	1558	Natural variant	ID=VAR_053064;Note=D->A;Dbxref=dbSNP:rs13179480
DOCK2	Q92608	1548	1576	1544	1550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YIN
DOCK2	Q92608	1548	1576	1553	1558	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YIN
DOCK2	Q92608	1548	1576	1560	1562	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B13
DOCK2	Q92608	1548	1576	1563	1589	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YIN
DOCK5	Q9H7D0	14	42	1	1870	Chain	ID=PRO_0000189992;Note=Dedicator of cytokinesis protein 5
DOCK5	Q9H7D0	950	983	1	1870	Chain	ID=PRO_0000189992;Note=Dedicator of cytokinesis protein 5
DOCK5	Q9H7D0	1312	1342	1	1870	Chain	ID=PRO_0000189992;Note=Dedicator of cytokinesis protein 5
DOCK5	Q9H7D0	14	42	8	69	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
DOCK5	Q9H7D0	1312	1342	1231	1642	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DOCK5	Q9H7D0	950	983	351	1870	Alternative sequence	ID=VSP_021868;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DOCK5	Q9H7D0	1312	1342	351	1870	Alternative sequence	ID=VSP_021868;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLA1	P09884	433	458	1	1462	Chain	ID=PRO_0000046428;Note=DNA polymerase alpha catalytic subunit
POLA1	P09884	776	816	1	1462	Chain	ID=PRO_0000046428;Note=DNA polymerase alpha catalytic subunit
POLA1	P09884	1343	1382	1	1462	Chain	ID=PRO_0000046428;Note=DNA polymerase alpha catalytic subunit
POLA1	P09884	1343	1382	1245	1376	Region	Note=DNA-binding region;Ontology_term=ECO:0000255;evidence=ECO:0000255
POLA1	P09884	1343	1382	1348	1374	Motif	Note=CysB motif
POLA1	P09884	1343	1382	1348	1348	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLA1	P09884	1343	1382	1353	1353	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLA1	P09884	1343	1382	1371	1371	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLA1	P09884	1343	1382	1374	1374	Metal binding	Note=Iron-sulfur (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
POLA1	P09884	433	458	431	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QCL
POLA1	P09884	433	458	441	445	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IUD
POLA1	P09884	433	458	448	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QCL
POLA1	P09884	776	816	776	779	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QCL
POLA1	P09884	776	816	785	798	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QCL
POLA1	P09884	1343	1382	1346	1349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA1	P09884	1343	1382	1351	1353	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA1	P09884	1343	1382	1356	1358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA1	P09884	1343	1382	1359	1362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K18
POLA1	P09884	1343	1382	1364	1367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N5G
POLA1	P09884	1343	1382	1368	1370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
POLA1	P09884	1343	1382	1372	1383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y97
IQCA1	Q86XH1	623	652	1	822	Chain	ID=PRO_0000283572;Note=Dynein regulatory complex protein 11
IQCA1	Q86XH1	520	556	1	822	Chain	ID=PRO_0000283572;Note=Dynein regulatory complex protein 11
IQCA1	Q86XH1	439	471	1	822	Chain	ID=PRO_0000283572;Note=Dynein regulatory complex protein 11
IQCA1	Q86XH1	337	378	1	822	Chain	ID=PRO_0000283572;Note=Dynein regulatory complex protein 11
IQCA1	Q86XH1	152	216	1	822	Chain	ID=PRO_0000283572;Note=Dynein regulatory complex protein 11
IQCA1	Q86XH1	152	216	207	236	Domain	Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQCA1	Q86XH1	439	471	351	487	Compositional bias	Note=Lys-rich
IQCA1	Q86XH1	337	378	351	487	Compositional bias	Note=Lys-rich
IQCA1	Q86XH1	337	378	338	378	Alternative sequence	ID=VSP_047012;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IQCA1	Q86XH1	439	471	470	470	Alternative sequence	ID=VSP_024327;Note=In isoform 2. D->DK;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
IQCA1	Q86XH1	337	378	362	362	Natural variant	ID=VAR_060984;Note=Q->R;Dbxref=dbSNP:rs3754644
IQCA1	Q86XH1	439	471	452	452	Natural variant	ID=VAR_031495;Note=K->R;Dbxref=dbSNP:rs10204742
IQCA1	Q86XH1	152	216	199	199	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCTE1	Q5JU00	282	432	1	501	Chain	ID=PRO_0000326525;Note=Dynein regulatory complex subunit 5
TCTE1	Q5JU00	282	432	308	321	Repeat	Note=LRR 1
TCTE1	Q5JU00	282	432	335	355	Repeat	Note=LRR 2
TCTE1	Q5JU00	282	432	363	383	Repeat	Note=LRR 3
TCTE1	Q5JU00	282	432	391	411	Repeat	Note=LRR 4
TCTE1	Q5JU00	282	432	419	439	Repeat	Note=LRR 5
DRP2	Q13474	392	417	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	705	726	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	727	748	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	392	417	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	705	726	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	727	748	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	392	417	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	705	726	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	727	748	1	957	Chain	ID=PRO_0000076083;Note=Dystrophin-related protein 2
DRP2	Q13474	727	748	748	748	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05AA6
DRP2	Q13474	727	748	748	748	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05AA6
DRP2	Q13474	727	748	748	748	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05AA6
DTWD2	Q8NBA8	199	242	1	298	Chain	ID=PRO_0000271128;Note=DTW domain-containing protein 2
DUSP11	O75319	253	311	1	377	Chain	ID=PRO_0000094816;Note=RNA/RNP complex-1-interacting phosphatase
DUSP11	O75319	253	311	213	273	Alternative sequence	ID=VSP_014136;Note=In isoform 2. YLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQNGPIRKNWNSSVPRSSDFEDSAHLMQ->RSLALSPRLECSGTISTHSKFCFPGSRRSPASASQVAGTTGARHHARLIFCIFSRDVVSPC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DUSP11	O75319	253	311	274	377	Alternative sequence	ID=VSP_014137;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DNAH9	Q9NYC9	506	545	1	4486	Chain	ID=PRO_0000114632;Note=Dynein heavy chain 9%2C axonemal
DNAH9	Q9NYC9	634	656	1	4486	Chain	ID=PRO_0000114632;Note=Dynein heavy chain 9%2C axonemal
DNAH9	Q9NYC9	3351	3414	1	4486	Chain	ID=PRO_0000114632;Note=Dynein heavy chain 9%2C axonemal
DNAH9	Q9NYC9	3657	3704	1	4486	Chain	ID=PRO_0000114632;Note=Dynein heavy chain 9%2C axonemal
DNAH9	Q9NYC9	3959	4035	1	4486	Chain	ID=PRO_0000114632;Note=Dynein heavy chain 9%2C axonemal
DNAH9	Q9NYC9	4035	4099	1	4486	Chain	ID=PRO_0000114632;Note=Dynein heavy chain 9%2C axonemal
DNAH9	Q9NYC9	506	545	1	1831	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH9	Q9NYC9	634	656	1	1831	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH9	Q9NYC9	3959	4035	3866	4092	Region	Note=AAA 6;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH9	Q9NYC9	4035	4099	3866	4092	Region	Note=AAA 6;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH9	Q9NYC9	506	545	504	529	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAH9	Q9NYC9	634	656	639	662	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAH9	Q9NYC9	3657	3704	3640	3675	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAH9	Q9NYC9	506	545	1	3688	Alternative sequence	ID=VSP_043443;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAH9	Q9NYC9	634	656	1	3688	Alternative sequence	ID=VSP_043443;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAH9	Q9NYC9	3351	3414	1	3688	Alternative sequence	ID=VSP_043443;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAH9	Q9NYC9	3657	3704	1	3688	Alternative sequence	ID=VSP_043443;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAH9	Q9NYC9	3959	4035	3961	4036	Alternative sequence	ID=VSP_035285;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
DNAH9	Q9NYC9	4035	4099	3961	4036	Alternative sequence	ID=VSP_035285;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
DNAH9	Q9NYC9	3657	3704	3664	3664	Natural variant	ID=VAR_036216;Note=In a breast cancer sample%3B somatic mutation. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs138874996,PMID:16959974
DNAH9	Q9NYC9	4035	4099	4036	4036	Natural variant	ID=VAR_046324;Note=D->N;Dbxref=dbSNP:rs17612861
DNAH9	Q9NYC9	3657	3704	3678	3678	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPNMB	Q14956	23	74	22	572	Chain	ID=PRO_0000024709;Note=Transmembrane glycoprotein NMB
GPNMB	Q14956	74	122	22	572	Chain	ID=PRO_0000024709;Note=Transmembrane glycoprotein NMB
GPNMB	Q14956	122	180	22	572	Chain	ID=PRO_0000024709;Note=Transmembrane glycoprotein NMB
GPNMB	Q14956	180	233	22	572	Chain	ID=PRO_0000024709;Note=Transmembrane glycoprotein NMB
GPNMB	Q14956	233	339	22	572	Chain	ID=PRO_0000024709;Note=Transmembrane glycoprotein NMB
GPNMB	Q14956	339	384	22	572	Chain	ID=PRO_0000024709;Note=Transmembrane glycoprotein NMB
GPNMB	Q14956	23	74	22	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	74	122	22	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	122	180	22	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	180	233	22	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	233	339	22	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	339	384	22	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	233	339	240	327	Domain	Note=PKD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00151
GPNMB	Q14956	23	74	64	66	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	233	339	320	332	Compositional bias	Note=Poly-Pro
GPNMB	Q14956	74	122	93	93	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	122	180	134	134	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	122	180	146	146	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	180	233	200	200	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GPNMB	Q14956	233	339	249	249	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GPNMB	Q14956	233	339	275	275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GPNMB	Q14956	233	339	296	296	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GPNMB	Q14956	233	339	300	300	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GPNMB	Q14956	233	339	306	306	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
GPNMB	Q14956	233	339	312	312	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPNMB	Q14956	339	384	340	351	Alternative sequence	ID=VSP_013001;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12609765,ECO:0000303|PubMed:7814155;Dbxref=PMID:12609765,PMID:7814155
GPNMB	Q14956	74	122	110	110	Natural variant	ID=VAR_036262;Note=In a breast cancer sample%3B somatic mutation. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs755767733,PMID:16959974
GPNMB	Q14956	180	233	189	572	Natural variant	ID=VAR_080643;Note=In PLCA3%3B may be expressed at much lower levels than wild-type protein%3B mislocalized to the endoplasmic reticulum and nuclear envelope. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=PMID:29336782
GPNMB	Q14956	233	339	189	572	Natural variant	ID=VAR_080643;Note=In PLCA3%3B may be expressed at much lower levels than wild-type protein%3B mislocalized to the endoplasmic reticulum and nuclear envelope. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=PMID:29336782
GPNMB	Q14956	339	384	189	572	Natural variant	ID=VAR_080643;Note=In PLCA3%3B may be expressed at much lower levels than wild-type protein%3B mislocalized to the endoplasmic reticulum and nuclear envelope. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=PMID:29336782
GPNMB	Q14956	180	233	195	195	Natural variant	ID=VAR_012076;Note=S->C;Dbxref=dbSNP:rs530436
GPNMB	Q14956	180	233	197	197	Natural variant	ID=VAR_012077;Note=N->H;Dbxref=dbSNP:rs530413
GPNMB	Q14956	180	233	220	572	Natural variant	ID=VAR_080644;Note=In PLCA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=PMID:29336782
GPNMB	Q14956	233	339	220	572	Natural variant	ID=VAR_080644;Note=In PLCA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=PMID:29336782
GPNMB	Q14956	339	384	220	572	Natural variant	ID=VAR_080644;Note=In PLCA3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=PMID:29336782
GPNMB	Q14956	233	339	294	294	Natural variant	ID=VAR_050603;Note=S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29336782;Dbxref=dbSNP:rs35499907,PMID:29336782
GPNMB	Q14956	233	339	324	324	Natural variant	ID=VAR_050604;Note=P->L;Dbxref=dbSNP:rs35363287
GPNMB	Q14956	339	384	354	354	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
APPL2	Q8NEU8	557	604	1	664	Chain	ID=PRO_0000079987;Note=DCC-interacting protein 13-beta
APPL2	Q8NEU8	235	287	1	664	Chain	ID=PRO_0000079987;Note=DCC-interacting protein 13-beta
APPL2	Q8NEU8	158	207	1	664	Chain	ID=PRO_0000079987;Note=DCC-interacting protein 13-beta
APPL2	Q8NEU8	71	95	1	664	Chain	ID=PRO_0000079987;Note=DCC-interacting protein 13-beta
APPL2	Q8NEU8	235	287	277	375	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APPL2	Q8NEU8	557	604	488	637	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APPL2	Q8NEU8	235	287	1	428	Region	Note=Required for RAB5A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
APPL2	Q8NEU8	158	207	1	428	Region	Note=Required for RAB5A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
APPL2	Q8NEU8	71	95	1	428	Region	Note=Required for RAB5A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
APPL2	Q8NEU8	235	287	234	235	Site	Note=Breakpoint for chromosomal translocation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11431708;Dbxref=PMID:11431708
APPL2	Q8NEU8	557	604	575	575	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
APPL2	Q8NEU8	71	95	80	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C5B
APPL2	Q8NEU8	158	207	157	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C5B
APPL2	Q8NEU8	235	287	220	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C5B
APPL2	Q8NEU8	235	287	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C5B
APPL2	Q8NEU8	235	287	266	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C5B
APPL2	Q8NEU8	235	287	281	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C5B
DPH1	Q9BZG8	232	254	1	443	Chain	ID=PRO_0000307882;Note=2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
DPH1	Q9BZG8	232	254	234	234	Natural variant	ID=VAR_076413;Note=In DEDSSH. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25558065;Dbxref=dbSNP:rs730882250,PMID:25558065
IQCD	Q96DY2	321	345	1	449	Chain	ID=PRO_0000282548;Note=Dynein regulatory complex protein 10
IQCD	Q96DY2	243	321	1	449	Chain	ID=PRO_0000282548;Note=Dynein regulatory complex protein 10
IQCD	Q96DY2	321	345	244	345	Alternative sequence	ID=VSP_024178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IQCD	Q96DY2	243	321	244	345	Alternative sequence	ID=VSP_024178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IQCD	Q96DY2	321	345	244	327	Alternative sequence	ID=VSP_024179;Note=In isoform 3. VEKENFVIQELKNHLHQVLKFSENSLVRTKQEAEKQQKADFRASQARVAKIQQEILQLQSQFYNLVMENREAEQALRKKKYKVE->VLFHSIAEITEEATQIFCWLGFSSMIDFFFKMESRSVVQTRVQWCNLDSLQPLPPRFKRFSHHSLPSSWDYRRMPPRPANFLYF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IQCD	Q96DY2	243	321	244	327	Alternative sequence	ID=VSP_024179;Note=In isoform 3. VEKENFVIQELKNHLHQVLKFSENSLVRTKQEAEKQQKADFRASQARVAKIQQEILQLQSQFYNLVMENREAEQALRKKKYKVE->VLFHSIAEITEEATQIFCWLGFSSMIDFFFKMESRSVVQTRVQWCNLDSLQPLPPRFKRFSHHSLPSSWDYRRMPPRPANFLYF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IQCD	Q96DY2	321	345	328	449	Alternative sequence	ID=VSP_024180;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DEPTOR	Q8TB45	201	263	1	409	Chain	ID=PRO_0000284784;Note=DEP domain-containing mTOR-interacting protein
DEPTOR	Q8TB45	332	367	1	409	Chain	ID=PRO_0000284784;Note=DEP domain-containing mTOR-interacting protein
DEPTOR	Q8TB45	201	263	145	219	Domain	Note=DEP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00066
DEPTOR	Q8TB45	332	367	330	407	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
DEPTOR	Q8TB45	201	263	222	226	Compositional bias	Note=Poly-Arg
DEPTOR	Q8TB45	201	263	235	299	Compositional bias	Note=Ser-rich
DEPTOR	Q8TB45	201	263	241	241	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19446321;Dbxref=PMID:19446321
DEPTOR	Q8TB45	201	263	244	244	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:19446321;Dbxref=PMID:23186163,PMID:19446321
DEPTOR	Q8TB45	201	263	258	258	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19446321;Dbxref=PMID:19446321
DEPTOR	Q8TB45	201	263	259	259	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19446321;Dbxref=PMID:19446321
DEPTOR	Q8TB45	201	263	263	263	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19446321;Dbxref=PMID:19446321
DEPTOR	Q8TB45	201	263	204	204	Natural variant	ID=VAR_031817;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11230166,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2271900,PMID:11230166,PMID:14702039,PMID:15489334
DEPTOR	Q8TB45	201	263	249	249	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DSC1	Q08554	625	705	135	894	Chain	ID=PRO_0000003864;Note=Desmocollin-1
DSC1	Q08554	625	705	135	691	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC1	Q08554	625	705	692	714	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSC1	Q08554	625	705	576	682	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSC1	Q08554	625	705	624	627	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRY
DSC1	Q08554	625	705	629	633	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRY
DSC1	Q08554	625	705	639	649	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRY
DSC1	Q08554	625	705	655	664	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRY
DUOX1	Q9NRD9	19	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	19	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	19	47	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	561	607	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	963	1004	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	1363	1416	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	19	47	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	561	607	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	963	1004	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	1363	1416	22	1551	Chain	ID=PRO_0000223344;Note=Dual oxidase 1
DUOX1	Q9NRD9	19	47	22	596	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	561	607	22	596	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	19	47	22	596	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	561	607	22	596	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	561	607	597	617	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	561	607	597	617	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	963	1004	618	1044	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	963	1004	618	1044	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	1363	1416	1270	1551	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	1363	1416	1270	1551	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOX1	Q9NRD9	1363	1416	1270	1376	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00716
DUOX1	Q9NRD9	1363	1416	1270	1376	Domain	Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00716
DUOX1	Q9NRD9	19	47	26	593	Region	Note=Peroxidase-like%3B mediates peroxidase activity
DUOX1	Q9NRD9	561	607	26	593	Region	Note=Peroxidase-like%3B mediates peroxidase activity
DUOX1	Q9NRD9	19	47	26	593	Region	Note=Peroxidase-like%3B mediates peroxidase activity
DUOX1	Q9NRD9	561	607	26	593	Region	Note=Peroxidase-like%3B mediates peroxidase activity
DUOX1	Q9NRD9	963	1004	956	1248	Region	Note=Interaction with TXNDC11;Ontology_term=ECO:0000250;evidence=ECO:0000250
DUOX1	Q9NRD9	963	1004	956	1248	Region	Note=Interaction with TXNDC11;Ontology_term=ECO:0000250;evidence=ECO:0000250
DUOX1	Q9NRD9	19	47	1	354	Alternative sequence	ID=VSP_017262;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DUOX1	Q9NRD9	19	47	1	354	Alternative sequence	ID=VSP_017262;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DUOX1	Q9NRD9	1363	1416	1388	1388	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
DUOX1	Q9NRD9	1363	1416	1388	1388	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	910	943	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	869	910	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	681	869	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	632	681	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	611	632	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	235	270	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	164	235	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	970	1006	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	910	943	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	869	910	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	681	869	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	632	681	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	611	632	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	235	270	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	164	235	2	1005	Chain	ID=PRO_0000219397;Note=Band 4.1-like protein 2
EPB41L2	O43491	235	270	218	499	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L2	O43491	164	235	218	499	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L2	O43491	235	270	218	499	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L2	O43491	164	235	218	499	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L2	O43491	632	681	611	676	Region	Note=Spectrin--actin-binding
EPB41L2	O43491	611	632	611	676	Region	Note=Spectrin--actin-binding
EPB41L2	O43491	632	681	611	676	Region	Note=Spectrin--actin-binding
EPB41L2	O43491	611	632	611	676	Region	Note=Spectrin--actin-binding
EPB41L2	O43491	910	943	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	869	910	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	681	869	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	970	1006	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	910	943	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	869	910	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	681	869	855	1005	Region	Note=C-terminal (CTD)
EPB41L2	O43491	164	235	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L2	O43491	164	235	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L2	O43491	164	235	208	208	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	164	235	208	208	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	611	632	614	614	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
EPB41L2	O43491	611	632	614	614	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
EPB41L2	O43491	611	632	623	623	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	611	632	623	623	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	611	632	627	627	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	611	632	627	627	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	632	681	647	647	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L2	O43491	632	681	647	647	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L2	O43491	681	869	715	715	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EPB41L2	O43491	681	869	715	715	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EPB41L2	O43491	681	869	718	718	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EPB41L2	O43491	681	869	718	718	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EPB41L2	O43491	681	869	763	763	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	681	869	763	763	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70318
EPB41L2	O43491	681	869	828	828	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L2	O43491	681	869	828	828	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EPB41L2	O43491	910	943	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	869	910	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	681	869	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	632	681	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	611	632	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	910	943	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	869	910	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	681	869	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	632	681	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	611	632	612	943	Alternative sequence	ID=VSP_042910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPB41L2	O43491	869	910	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	681	869	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	632	681	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	611	632	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	869	910	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	681	869	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	632	681	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	611	632	612	869	Alternative sequence	ID=VSP_045090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
EPB41L2	O43491	681	869	612	681	Alternative sequence	ID=VSP_047181;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	632	681	612	681	Alternative sequence	ID=VSP_047181;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	611	632	612	681	Alternative sequence	ID=VSP_047181;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	681	869	612	681	Alternative sequence	ID=VSP_047181;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	632	681	612	681	Alternative sequence	ID=VSP_047181;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	611	632	612	681	Alternative sequence	ID=VSP_047181;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	869	910	787	869	Alternative sequence	ID=VSP_047182;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	681	869	787	869	Alternative sequence	ID=VSP_047182;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	869	910	787	869	Alternative sequence	ID=VSP_047182;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L2	O43491	681	869	787	869	Alternative sequence	ID=VSP_047182;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPB41L5	Q9HCM4	60	95	1	733	Chain	ID=PRO_0000219406;Note=Band 4.1-like protein 5
EPB41L5	Q9HCM4	533	576	1	733	Chain	ID=PRO_0000219406;Note=Band 4.1-like protein 5
EPB41L5	Q9HCM4	629	654	1	733	Chain	ID=PRO_0000219406;Note=Band 4.1-like protein 5
EPB41L5	Q9HCM4	60	95	43	327	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
EPB41L5	Q9HCM4	533	576	506	733	Alternative sequence	ID=VSP_033035;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
EPB41L5	Q9HCM4	629	654	506	733	Alternative sequence	ID=VSP_033035;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ECD	O95905	261	304	1	644	Chain	ID=PRO_0000220844;Note=Protein ecdysoneless homolog
ECD	O95905	261	304	262	304	Alternative sequence	ID=VSP_045670;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
ECD	O95905	261	304	281	281	Natural variant	ID=VAR_012191;Note=Could be a rare polymorphism. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11090341;Dbxref=dbSNP:rs151023501,PMID:11090341
DDX19B	Q9UMR2	99	129	2	479	Chain	ID=PRO_0000055022;Note=ATP-dependent RNA helicase DDX19B
DDX19B	Q9UMR2	99	129	125	295	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX19B	Q9UMR2	99	129	2	300	Region	Note=N-terminal lobe
DDX19B	Q9UMR2	99	129	92	120	Motif	Note=Q motif
DDX19B	Q9UMR2	99	129	119	119	Binding site	Note=ATP
DDX19B	Q9UMR2	99	129	1	109	Alternative sequence	ID=VSP_041347;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12219940,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:12219940,PMID:14702039,PMID:15489334
DDX19B	Q9UMR2	99	129	100	130	Alternative sequence	ID=VSP_015239;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:11230166,PMID:14702039
DDX19B	Q9UMR2	99	129	128	128	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX19B	Q9UMR2	99	129	101	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHT
DDX19B	Q9UMR2	99	129	117	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHT
DDX19B	Q9UMR2	99	129	128	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHT
DDHD2	O94830	207	237	1	711	Chain	ID=PRO_0000309330;Note=Phospholipase DDHD2
DDHD2	O94830	375	416	1	711	Chain	ID=PRO_0000309330;Note=Phospholipase DDHD2
DDHD2	O94830	416	448	1	711	Chain	ID=PRO_0000309330;Note=Phospholipase DDHD2
DDHD2	O94830	207	237	1	711	Chain	ID=PRO_0000309330;Note=Phospholipase DDHD2
DDHD2	O94830	375	416	1	711	Chain	ID=PRO_0000309330;Note=Phospholipase DDHD2
DDHD2	O94830	416	448	1	711	Chain	ID=PRO_0000309330;Note=Phospholipase DDHD2
DDHD2	O94830	375	416	385	448	Domain	Note=SAM
DDHD2	O94830	416	448	385	448	Domain	Note=SAM
DDHD2	O94830	375	416	385	448	Domain	Note=SAM
DDHD2	O94830	416	448	385	448	Domain	Note=SAM
DDHD2	O94830	416	448	447	447	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80Y98
DDHD2	O94830	416	448	447	447	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80Y98
DDHD2	O94830	207	237	1	381	Alternative sequence	ID=VSP_056087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDHD2	O94830	375	416	1	381	Alternative sequence	ID=VSP_056087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDHD2	O94830	207	237	1	381	Alternative sequence	ID=VSP_056087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDHD2	O94830	375	416	1	381	Alternative sequence	ID=VSP_056087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDHD2	O94830	416	448	434	434	Mutagenesis	Note=Loss of phospholipid binding and of Golgi/ERGIC localization%3B when associated with A-435 and A-436. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DDHD2	O94830	416	448	434	434	Mutagenesis	Note=Loss of phospholipid binding and of Golgi/ERGIC localization%3B when associated with A-435 and A-436. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DDHD2	O94830	416	448	435	435	Mutagenesis	Note=Loss of phospholipid binding and of Golgi/ERGIC localization%3B when associated with A-434 and A-436. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DDHD2	O94830	416	448	435	435	Mutagenesis	Note=Loss of phospholipid binding and of Golgi/ERGIC localization%3B when associated with A-434 and A-436. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DDHD2	O94830	416	448	436	436	Mutagenesis	Note=Loss of phospholipid binding and of Golgi/ERGIC localization%3B when associated with A-434 and A-435. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DDHD2	O94830	416	448	436	436	Mutagenesis	Note=Loss of phospholipid binding and of Golgi/ERGIC localization%3B when associated with A-434 and A-435. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DDHD2	O94830	375	416	376	376	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDHD2	O94830	375	416	376	376	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B12	Q53GQ0	94	130	1	312	Chain	ID=PRO_0000248368;Note=Very-long-chain 3-oxoacyl-CoA reductase
HSD17B12	Q53GQ0	152	167	1	312	Chain	ID=PRO_0000248368;Note=Very-long-chain 3-oxoacyl-CoA reductase
HSD17B12	Q53GQ0	94	130	95	98	Alternative sequence	ID=VSP_056380;Note=In isoform 2. KEKF->SNYT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HSD17B12	Q53GQ0	94	130	99	312	Alternative sequence	ID=VSP_056381;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HSD17B12	Q53GQ0	152	167	99	312	Alternative sequence	ID=VSP_056381;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HSD17B13	Q7Z5P4	232	270	20	300	Chain	ID=PRO_0000042583;Note=17-beta-hydroxysteroid dehydrogenase 13
HSD17B13	Q7Z5P4	70	106	20	300	Chain	ID=PRO_0000042583;Note=17-beta-hydroxysteroid dehydrogenase 13
HSD17B13	Q7Z5P4	70	106	71	106	Alternative sequence	ID=VSP_015860;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
HSD17B13	Q7Z5P4	232	270	260	260	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD17B14	Q9BPX1	123	158	1	270	Chain	ID=PRO_0000054654;Note=17-beta-hydroxysteroid dehydrogenase 14
HSD17B14	Q9BPX1	123	158	154	154	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
HSD17B14	Q9BPX1	123	158	141	141	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSD17B14	Q9BPX1	123	158	158	158	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSD17B14	Q9BPX1	123	158	130	130	Natural variant	ID=VAR_052308;Note=R->W;Dbxref=dbSNP:rs35299026
HSD17B14	Q9BPX1	123	158	116	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6X
HSD17B14	Q9BPX1	123	158	135	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6X
HSD17B14	Q9BPX1	123	158	143	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6X
HSD17B14	Q9BPX1	123	158	152	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O6X
HSD17B2	P37059	88	159	1	387	Chain	ID=PRO_0000054570;Note=Estradiol 17-beta-dehydrogenase 2
HSD17B2	P37059	221	267	1	387	Chain	ID=PRO_0000054570;Note=Estradiol 17-beta-dehydrogenase 2
HSD17B2	P37059	88	159	82	111	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSD17B2	P37059	221	267	232	232	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSD17B2	P37059	88	159	121	121	Natural variant	ID=VAR_018852;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs8191136
DHRS12	A0PJE2	235	281	1	317	Chain	ID=PRO_0000312175;Note=Dehydrogenase/reductase SDR family member 12
DHRS12	A0PJE2	235	281	236	317	Alternative sequence	ID=VSP_029725;Note=In isoform 3. GVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQDRKPVSTHLPLATASSSPAEEEKLIEILEQLAQTFK->DRNEQELRKVVGEAQTASPLPRFLEIMMHEGKCQPQGHSSNDLEACWSSGGGEQNSLPDWPHQLHDLRQLTWALCSSFLLYKQGN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAI2	Q9GZS0	203	241	1	605	Chain	ID=PRO_0000114659;Note=Dynein intermediate chain 2%2C axonemal
DNAI2	Q9GZS0	203	241	1	605	Chain	ID=PRO_0000114659;Note=Dynein intermediate chain 2%2C axonemal
DNAI2	Q9GZS0	203	241	150	203	Repeat	Note=WD 1
DNAI2	Q9GZS0	203	241	150	203	Repeat	Note=WD 1
DNAI2	Q9GZS0	203	241	208	246	Repeat	Note=WD 2
DNAI2	Q9GZS0	203	241	208	246	Repeat	Note=WD 2
DNAJC4	Q9NNZ3	122	175	1	241	Chain	ID=PRO_0000071049;Note=DnaJ homolog subfamily C member 4
DNAJC4	Q9NNZ3	122	175	156	175	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DNASE1L3	Q13609	77	106	21	305	Chain	ID=PRO_0000007288;Note=Deoxyribonuclease gamma
DNASE1L3	Q13609	77	106	100	100	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00639
DNASE1L3	Q13609	77	106	78	107	Alternative sequence	ID=VSP_047251;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNASE1L3	Q13609	77	106	82	82	Natural variant	ID=VAR_036080;Note=In a breast cancer sample%3B somatic mutation%3B diminishes enzymatic activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:21692081;Dbxref=dbSNP:rs74350392,PMID:16959974,PMID:21692081
DNASE1L3	Q13609	77	106	96	96	Natural variant	ID=VAR_059249;Note=N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14646506;Dbxref=dbSNP:rs12491947,PMID:14646506
DOLPP1	Q86YN1	154	196	1	238	Chain	ID=PRO_0000215626;Note=Dolichyldiphosphatase 1
DOLPP1	Q86YN1	154	196	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DOLPP1	Q86YN1	154	196	155	197	Alternative sequence	ID=VSP_042210;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOK7	Q18PE1	110	177	1	504	Chain	ID=PRO_0000250371;Note=Protein Dok-7
DOK7	Q18PE1	177	217	1	504	Chain	ID=PRO_0000250371;Note=Protein Dok-7
DOK7	Q18PE1	217	257	1	504	Chain	ID=PRO_0000250371;Note=Protein Dok-7
DOK7	Q18PE1	110	177	105	210	Domain	Note=IRS-type PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00389
DOK7	Q18PE1	177	217	105	210	Domain	Note=IRS-type PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00389
DOK7	Q18PE1	110	177	1	138	Alternative sequence	ID=VSP_020633;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOK7	Q18PE1	110	177	139	178	Alternative sequence	ID=VSP_020634;Note=In isoform 2. VLARDIPPAVTGQWKLSDLRRYGAVPSGFIFEGGTRCGYW->MMSSSWPGTSPRLSRGSGSCLTSGATGPCQADSSLKAGPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOK7	Q18PE1	177	217	139	178	Alternative sequence	ID=VSP_020634;Note=In isoform 2. VLARDIPPAVTGQWKLSDLRRYGAVPSGFIFEGGTRCGYW->MMSSSWPGTSPRLSRGSGSCLTSGATGPCQADSSLKAGPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DOK7	Q18PE1	110	177	175	255	Alternative sequence	ID=VSP_047252;Note=In isoform 4. CGYWAGVFFLSSAEGEQISFLFDCIVRGISPTKGPFGLRPVLPDPSPPGPSTVEERVAQEALETLQLEKRLSLLSHAGRPG->GWRLLPVLGRGGADQLPVRLHRPRHLPHQGPLWAAAGSTRPKSPGTLDCGGACGPGSPGNPTAGEAAEPPLTCGQAGQWRG;Ontology_term=ECO:0000305;evidence=ECO:0000305
DOK7	Q18PE1	177	217	175	255	Alternative sequence	ID=VSP_047252;Note=In isoform 4. CGYWAGVFFLSSAEGEQISFLFDCIVRGISPTKGPFGLRPVLPDPSPPGPSTVEERVAQEALETLQLEKRLSLLSHAGRPG->GWRLLPVLGRGGADQLPVRLHRPRHLPHQGPLWAAAGSTRPKSPGTLDCGGACGPGSPGNPTAGEAAEPPLTCGQAGQWRG;Ontology_term=ECO:0000305;evidence=ECO:0000305
DOK7	Q18PE1	217	257	175	255	Alternative sequence	ID=VSP_047252;Note=In isoform 4. CGYWAGVFFLSSAEGEQISFLFDCIVRGISPTKGPFGLRPVLPDPSPPGPSTVEERVAQEALETLQLEKRLSLLSHAGRPG->GWRLLPVLGRGGADQLPVRLHRPRHLPHQGPLWAAAGSTRPKSPGTLDCGGACGPGSPGNPTAGEAAEPPLTCGQAGQWRG;Ontology_term=ECO:0000305;evidence=ECO:0000305
DOK7	Q18PE1	217	257	256	504	Alternative sequence	ID=VSP_047253;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DOK7	Q18PE1	110	177	116	116	Natural variant	ID=VAR_068757;Note=In CMS10. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20012313;Dbxref=PMID:20012313
DOK7	Q18PE1	110	177	132	132	Natural variant	ID=VAR_068758;Note=In CMS10. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17439981;Dbxref=PMID:17439981
DOK7	Q18PE1	110	177	139	139	Natural variant	ID=VAR_068759;Note=In CMS10%3B results in a significant reduction of AChR clusters. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22661499;Dbxref=PMID:22661499
DOK7	Q18PE1	110	177	146	146	Natural variant	ID=VAR_068760;Note=In CMS10. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20012313;Dbxref=dbSNP:rs770987150,PMID:20012313
DOK7	Q18PE1	110	177	157	157	Natural variant	ID=VAR_068761;Note=In CMS10. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20012313;Dbxref=PMID:20012313
DOK7	Q18PE1	110	177	158	158	Natural variant	ID=VAR_031246;Note=In CMS10%3B reduced stimulation of MUSK autophosphorylation when associated with A-174%3B results in a significant reduction of AChR clusters. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20603078,ECO:0000269|PubMed:22661499;Dbxref=dbSNP:rs6811423,PMID:20603078,PMID:22661499
DOK7	Q18PE1	110	177	161	161	Natural variant	ID=VAR_068762;Note=In CMS10%3B results in a significant reduction of AChR clusters. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22661499;Dbxref=dbSNP:rs758131044,PMID:22661499
DOK7	Q18PE1	110	177	166	166	Natural variant	ID=VAR_068763;Note=In CMS10%3B results in a significant reduction of AChR clusters. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22661499;Dbxref=dbSNP:rs781227659,PMID:22661499
DOK7	Q18PE1	110	177	171	171	Natural variant	ID=VAR_068764;Note=In CMS10%3B results in a significant reduction of AChR clusters. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22661499;Dbxref=PMID:22661499
DOK7	Q18PE1	110	177	171	171	Natural variant	ID=VAR_068765;Note=In CMS10. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20012313;Dbxref=PMID:20012313
DOK7	Q18PE1	110	177	172	172	Natural variant	ID=VAR_068766;Note=In CMS10. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20012313;Dbxref=dbSNP:rs768892432,PMID:20012313
DOK7	Q18PE1	177	217	180	180	Natural variant	ID=VAR_027544;Note=In CMS10%3B results in a significant reduction of AChR clusters. G->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16917026,ECO:0000269|PubMed:22661499;Dbxref=dbSNP:rs118203994,PMID:16917026,PMID:22661499
DOK7	Q18PE1	177	217	180	180	Natural variant	ID=VAR_068767;Note=In CMS10. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20012313;Dbxref=PMID:20012313
DOK7	Q18PE1	177	217	197	197	Natural variant	ID=VAR_027545;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22661499;Dbxref=dbSNP:rs16844422,PMID:22661499
DOK7	Q18PE1	110	177	174	174	Mutagenesis	Note=Reduced stimulation of MUSK autophosphorylation%3B when associated with Q-158. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20603078;Dbxref=PMID:20603078
DOCK10	Q96BY6	1737	1770	1	2186	Chain	ID=PRO_0000190002;Note=Dedicator of cytokinesis protein 10
DOCK10	Q96BY6	1609	1646	1	2186	Chain	ID=PRO_0000190002;Note=Dedicator of cytokinesis protein 10
DOCK10	Q96BY6	1121	1136	1	2186	Chain	ID=PRO_0000190002;Note=Dedicator of cytokinesis protein 10
DOCK10	Q96BY6	1012	1061	1	2186	Chain	ID=PRO_0000190002;Note=Dedicator of cytokinesis protein 10
DOCK10	Q96BY6	562	602	1	2186	Chain	ID=PRO_0000190002;Note=Dedicator of cytokinesis protein 10
DOCK10	Q96BY6	163	204	1	2186	Chain	ID=PRO_0000190002;Note=Dedicator of cytokinesis protein 10
DOCK10	Q96BY6	163	204	181	290	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
DOCK10	Q96BY6	1737	1770	1690	2150	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DOCK10	Q96BY6	163	204	196	196	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BZN6
DOCK10	Q96BY6	562	602	565	593	Alternative sequence	ID=VSP_007716;Note=In isoform 2. FKDNQGNVDRDSRFSPLFRQESSKISTED->DSCSQQTRNTFNGGIGSFSFERFCVAYYF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
DOCK10	Q96BY6	1737	1770	594	2186	Alternative sequence	ID=VSP_007717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
DOCK10	Q96BY6	1609	1646	594	2186	Alternative sequence	ID=VSP_007717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
DOCK10	Q96BY6	1121	1136	594	2186	Alternative sequence	ID=VSP_007717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
DOCK10	Q96BY6	1012	1061	594	2186	Alternative sequence	ID=VSP_007717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
DOCK10	Q96BY6	562	602	594	2186	Alternative sequence	ID=VSP_007717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
DOCK10	Q96BY6	562	602	563	563	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
DALRD3	Q5D0E6	481	504	1	543	Chain	ID=PRO_0000315848;Note=DALR anticodon-binding domain-containing protein 3
DALRD3	Q5D0E6	443	481	1	543	Chain	ID=PRO_0000315848;Note=DALR anticodon-binding domain-containing protein 3
DALRD3	Q5D0E6	481	504	139	543	Alternative sequence	ID=VSP_030744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DALRD3	Q5D0E6	443	481	139	543	Alternative sequence	ID=VSP_030744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DALRD3	Q5D0E6	481	504	444	543	Alternative sequence	ID=VSP_030746;Note=In isoform 2. GEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTEMICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPLSHI->YPPLSGSAEPDSSAGLHSPGAPHCCTHRDDMQVPGTAQHGFQLLLQPGTHPGGASTTPLWSDVRPPAASESCA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DALRD3	Q5D0E6	443	481	444	543	Alternative sequence	ID=VSP_030746;Note=In isoform 2. GEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTEMICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPLSHI->YPPLSGSAEPDSSAGLHSPGAPHCCTHRDDMQVPGTAQHGFQLLLQPGTHPGGASTTPLWSDVRPPAASESCA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DYNC1LI1	Q9Y6G9	360	380	1	523	Chain	ID=PRO_0000114666;Note=Cytoplasmic dynein 1 light intermediate chain 1
DYNC1LI1	Q9Y6G9	73	112	1	523	Chain	ID=PRO_0000114666;Note=Cytoplasmic dynein 1 light intermediate chain 1
DYNC1LI1	Q9Y6G9	73	112	74	81	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCLRE1B	Q9H816	118	179	1	532	Chain	ID=PRO_0000209119;Note=5' exonuclease Apollo
DCLRE1B	Q9H816	118	179	125	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AHO
DCLRE1B	Q9H816	118	179	131	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AHO
DCLRE1B	Q9H816	118	179	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AHO
DCLRE1B	Q9H816	118	179	158	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AHO
DCLRE1B	Q9H816	118	179	175	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AHO
HSD17B4	P51659	420	444	1	736	Chain	ID=PRO_0000054583;Note=Peroxisomal multifunctional enzyme type 2
HSD17B4	P51659	479	501	1	736	Chain	ID=PRO_0000054583;Note=Peroxisomal multifunctional enzyme type 2
HSD17B4	P51659	396	420	1	736	Chain	ID=PRO_0000054583;Note=Peroxisomal multifunctional enzyme type 2
HSD17B4	P51659	455	477	1	736	Chain	ID=PRO_0000054583;Note=Peroxisomal multifunctional enzyme type 2
HSD17B4	P51659	420	444	312	736	Chain	ID=PRO_0000400083;Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	479	501	312	736	Chain	ID=PRO_0000400083;Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	396	420	312	736	Chain	ID=PRO_0000400083;Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	455	477	312	736	Chain	ID=PRO_0000400083;Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	479	501	484	600	Domain	Note=MaoC-like
HSD17B4	P51659	420	444	322	622	Region	Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	479	501	322	622	Region	Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	396	420	322	622	Region	Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	455	477	322	622	Region	Note=Enoyl-CoA hydratase 2
HSD17B4	P51659	396	420	406	407	Region	Note=(3R)-3-hydroxydecanoyl-CoA binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSD17B4	P51659	420	444	435	435	Binding site	Note=(3R)-3-hydroxydecanoyl-CoA;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSD17B4	P51659	420	444	424	424	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660
HSD17B4	P51659	420	444	427	427	Natural variant	ID=VAR_052311;Note=A->V;Dbxref=dbSNP:rs28943590
HSD17B4	P51659	455	477	457	457	Natural variant	ID=VAR_065908;Note=In DBPD%3B the mutation leads to an unstable protein. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10400999;Dbxref=dbSNP:rs137853097,PMID:10400999
HSD17B4	P51659	479	501	491	491	Natural variant	ID=VAR_052312;Note=A->T;Dbxref=dbSNP:rs28943591
HSD17B4	P51659	396	420	406	406	Mutagenesis	Note=No effect. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535
HSD17B4	P51659	396	420	408	408	Mutagenesis	Note=No effect. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535
HSD17B4	P51659	396	420	410	410	Mutagenesis	Note=No effect. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535
HSD17B4	P51659	479	501	490	490	Mutagenesis	Note=No effect. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535
HSD17B4	P51659	396	420	401	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	396	420	405	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	420	444	419	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	396	420	419	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	420	444	440	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	455	477	440	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	479	501	490	496	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
HSD17B4	P51659	479	501	501	505	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9C
DHRS13	Q6UX07	123	227	26	377	Chain	ID=PRO_0000311920;Note=Dehydrogenase/reductase SDR family member 13
DHRS13	Q6UX07	123	227	197	197	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHRS13	Q6UX07	123	227	170	170	Binding site	Note=Substrate;Ontology_term=ECO:0000255;evidence=ECO:0000255
DHRS13	Q6UX07	123	227	43	123	Alternative sequence	ID=VSP_057529;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DHRS13	Q6UX07	123	227	191	191	Natural variant	ID=VAR_037348;Note=R->Q;Dbxref=dbSNP:rs2277666
DNAL1	Q4LDG9	1	14	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
DNAL1	Q4LDG9	1	14	2	190	Chain	ID=PRO_0000281130;Note=Dynein light chain 1%2C axonemal
DNAL1	Q4LDG9	130	177	2	190	Chain	ID=PRO_0000281130;Note=Dynein light chain 1%2C axonemal
DNAL1	Q4LDG9	130	177	116	137	Repeat	Note=LRR 4
DNAL1	Q4LDG9	130	177	150	190	Domain	Note=LRRCT
DNAL1	Q4LDG9	1	14	2	2	Modified residue	Note=N-acetylalanine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
DNAL1	Q4LDG9	1	14	1	113	Alternative sequence	ID=VSP_023982;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DNAL1	Q4LDG9	1	14	1	39	Alternative sequence	ID=VSP_043590;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAL1	Q4LDG9	130	177	150	150	Natural variant	ID=VAR_065739;Note=In CILD16%3B reduced tethering interaction between DNAH5 and tubulin. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21496787;Dbxref=dbSNP:rs387907021,PMID:21496787
LIG1	P18858	813	861	1	919	Chain	ID=PRO_0000059570;Note=DNA ligase 1
LIG1	P18858	744	795	1	919	Chain	ID=PRO_0000059570;Note=DNA ligase 1
LIG1	P18858	575	607	1	919	Chain	ID=PRO_0000059570;Note=DNA ligase 1
LIG1	P18858	155	191	1	919	Chain	ID=PRO_0000059570;Note=DNA ligase 1
LIG1	P18858	123	155	1	919	Chain	ID=PRO_0000059570;Note=DNA ligase 1
LIG1	P18858	6	35	1	919	Chain	ID=PRO_0000059570;Note=DNA ligase 1
LIG1	P18858	575	607	589	589	Binding site	Note=ATP
LIG1	P18858	744	795	744	744	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1X9N,ECO:0000269|PubMed:15565146;Dbxref=PMID:15565146
LIG1	P18858	575	607	590	590	Site	Note=Interaction with target DNA
LIG1	P18858	744	795	770	770	Site	Note=Interaction with target DNA
LIG1	P18858	744	795	795	795	Site	Note=Interaction with target DNA
LIG1	P18858	123	155	141	141	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
LIG1	P18858	813	861	819	819	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LIG1	P18858	6	35	7	36	Alternative sequence	ID=VSP_057320;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LIG1	P18858	123	155	153	153	Alternative sequence	ID=VSP_057321;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LIG1	P18858	813	861	802	919	Alternative sequence	ID=VSP_056140;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LIG1	P18858	6	35	24	24	Natural variant	ID=VAR_018802;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3730855
LIG1	P18858	123	155	152	152	Natural variant	ID=VAR_036511;Note=In a colorectal cancer sample%3B somatic mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs780748107,PMID:16959974
LIG1	P18858	744	795	771	771	Natural variant	ID=VAR_002263;Note=Found in a patient with a syndrome of immunodeficiency and increased cellular sensitivity to DNA-damaging agents due to LIG1 deficiency%3B compound heterozygote carrying K-566. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1581963;Dbxref=dbSNP:rs121434561,PMID:1581963
LIG1	P18858	575	607	563	578	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	575	607	584	587	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	575	607	595	597	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	575	607	599	603	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	575	607	606	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	744	795	739	746	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	744	795	747	751	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	744	795	755	767	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	744	795	774	784	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	744	795	785	788	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	744	795	789	796	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	813	861	802	814	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	813	861	816	819	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	813	861	827	829	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	813	861	833	836	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	813	861	841	854	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
LIG1	P18858	813	861	857	861	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X9N
DNAJA1	P31689	103	138	1	394	Chain	ID=PRO_0000071008;Note=DnaJ homolog subfamily A member 1
DNAJA1	P31689	138	214	1	394	Chain	ID=PRO_0000071008;Note=DnaJ homolog subfamily A member 1
DNAJA1	P31689	103	138	134	141	Repeat	Note=CXXCXGXG motif
DNAJA1	P31689	138	214	134	141	Repeat	Note=CXXCXGXG motif
DNAJA1	P31689	138	214	150	157	Repeat	Note=CXXCXGXG motif
DNAJA1	P31689	138	214	177	184	Repeat	Note=CXXCXGXG motif
DNAJA1	P31689	138	214	193	200	Repeat	Note=CXXCXGXG motif
DNAJA1	P31689	103	138	121	205	Zinc finger	Note=CR-type
DNAJA1	P31689	138	214	121	205	Zinc finger	Note=CR-type
DNAJA1	P31689	103	138	134	134	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	103	138	137	137	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	138	214	150	150	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	138	214	153	153	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	138	214	177	177	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	138	214	180	180	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	138	214	193	193	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJA1	P31689	138	214	196	196	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJC1	Q96KC8	326	366	48	554	Chain	ID=PRO_0000071042;Note=DnaJ homolog subfamily C member 1
DNAJC1	Q96KC8	326	366	175	554	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJC1	Q96KC8	326	366	325	379	Domain	Note=SANT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
DNAJC1	Q96KC8	326	366	332	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQQ
DNAJC1	Q96KC8	326	366	352	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQQ
DNAJC1	Q96KC8	326	366	364	376	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQQ
DOK4	Q8TEW6	96	136	1	326	Chain	ID=PRO_0000187274;Note=Docking protein 4
DOK4	Q8TEW6	96	136	1	326	Chain	ID=PRO_0000187274;Note=Docking protein 4
DOK4	Q8TEW6	96	136	7	112	Domain	Note=PH
DOK4	Q8TEW6	96	136	7	112	Domain	Note=PH
DOK4	Q8TEW6	96	136	132	237	Domain	Note=IRS-type PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00389
DOK4	Q8TEW6	96	136	132	237	Domain	Note=IRS-type PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00389
DUOXA1	Q1HG43	68	113	1	343	Chain	ID=PRO_0000264241;Note=Dual oxidase maturation factor 1
DUOXA1	Q1HG43	68	113	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA1	Q1HG43	68	113	73	183	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA1	Q1HG43	68	113	84	84	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA1	Q1HG43	68	113	109	109	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DUOXA1	Q1HG43	68	113	69	113	Alternative sequence	ID=VSP_021890;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNASE2	O00115	115	170	19	360	Chain	ID=PRO_0000007291;Note=Deoxyribonuclease-2-alpha
DNASE2	O00115	115	170	19	159	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNASE2	O00115	115	170	116	170	Alternative sequence	ID=VSP_056921;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNASE2	O00115	115	170	151	151	Mutagenesis	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498
DNASE2	O00115	115	170	159	159	Mutagenesis	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498
DNASE2	O00115	115	170	160	171	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPC1	P35052	338	378	24	530	Chain	ID=PRO_0000012295;Note=Glypican-1
GPC1	P35052	338	378	191	343	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351761;Dbxref=PMID:22351761
GPC1	P35052	338	378	268	415	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351761;Dbxref=PMID:22351761
GPC1	P35052	338	378	272	401	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22351761;Dbxref=PMID:22351761
GPC1	P35052	338	378	295	359	Alternative sequence	ID=VSP_055226;Note=In isoform 2. DSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKR->GEPPPARAAWNCLGECTTGGPGGRVVPSLELGPRDLIRDALTRARSGWCCRVEGPGCLLNVLSDV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPC1	P35052	338	378	360	558	Alternative sequence	ID=VSP_055227;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPC1	P35052	338	378	340	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YWT
GPC1	P35052	338	378	374	388	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YWT
POLE2	P56282	164	192	1	527	Chain	ID=PRO_0000071562;Note=DNA polymerase epsilon subunit 2
POLE2	P56282	139	164	1	527	Chain	ID=PRO_0000071562;Note=DNA polymerase epsilon subunit 2
POLE2	P56282	82	107	1	527	Chain	ID=PRO_0000071562;Note=DNA polymerase epsilon subunit 2
POLE2	P56282	82	107	83	108	Alternative sequence	ID=VSP_042551;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POLE2	P56282	82	107	84	84	Natural variant	ID=VAR_044379;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs34857719
POLE2	P56282	82	107	86	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	82	107	91	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	82	107	97	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	82	107	101	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	82	107	105	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	139	164	123	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	164	192	168	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
POLE2	P56282	164	192	178	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VBN
DRC1	Q96MC2	533	563	1	740	Chain	ID=PRO_0000277881;Note=Dynein regulatory complex protein 1
DPYSL3	Q14195	427	487	1	570	Chain	ID=PRO_0000165917;Note=Dihydropyrimidinase-related protein 3
DPYSL3	Q14195	180	207	1	570	Chain	ID=PRO_0000165917;Note=Dihydropyrimidinase-related protein 3
DPYSL3	Q14195	427	487	431	431	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62188
DPYSL3	Q14195	427	487	442	442	Natural variant	ID=VAR_020485;Note=A->S;Dbxref=dbSNP:rs2304044
DPYSL3	Q14195	180	207	178	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	180	207	194	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	180	207	202	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	427	487	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	427	487	433	436	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	427	487	438	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	427	487	451	455	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYSL3	Q14195	427	487	476	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKN
DPYS	Q14117	88	141	1	519	Chain	ID=PRO_0000165906;Note=Dihydropyrimidinase
DPYS	Q14117	88	141	85	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DPYS	Q14117	88	141	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DPYS	Q14117	88	141	95	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DPYS	Q14117	88	141	110	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DPYS	Q14117	88	141	122	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DPYS	Q14117	88	141	126	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DPYS	Q14117	88	141	140	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VR2
DUS3L	Q96G46	300	314	2	650	Chain	ID=PRO_0000247342;Note=tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
DUS3L	Q96G46	300	314	311	313	Nucleotide binding	Note=FMN;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SMC7
DUS3L	Q96G46	300	314	59	300	Alternative sequence	ID=VSP_019970;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DDR2	Q16832	366	387	22	855	Chain	ID=PRO_0000016746;Note=Discoidin domain-containing receptor 2
DDR2	Q16832	366	387	22	855	Chain	ID=PRO_0000016746;Note=Discoidin domain-containing receptor 2
DDR2	Q16832	366	387	22	399	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DDR2	Q16832	366	387	22	399	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DDR2	Q16832	366	387	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DDR2	Q16832	366	387	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DDX25	Q9UHL0	400	463	1	483	Chain	ID=PRO_0000030813;Note=ATP-dependent RNA helicase DDX25
DDX25	Q9UHL0	400	463	311	478	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX25	Q9UHL0	400	463	400	402	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	407	414	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	425	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	442	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	453	463	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX1	Q92499	44	54	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	102	130	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	339	372	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	402	465	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	44	54	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	102	130	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	339	372	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	402	465	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	44	54	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	102	130	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	339	372	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	402	465	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	44	54	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	102	130	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	339	372	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	402	465	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	102	130	70	247	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
DDX1	Q92499	102	130	70	247	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
DDX1	Q92499	44	54	46	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX1	Q92499	44	54	46	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX1	Q92499	44	54	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	102	130	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	339	372	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	402	465	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	44	54	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	102	130	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	339	372	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	402	465	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	44	54	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	102	130	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	339	372	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	402	465	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	44	54	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	102	130	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	339	372	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	402	465	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	44	54	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	102	130	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	44	54	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	102	130	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	339	372	370	373	Motif	Note=DEAD box
DDX1	Q92499	339	372	370	373	Motif	Note=DEAD box
DDX1	Q92499	44	54	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	44	54	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	98	113	Alternative sequence	ID=VSP_055454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	98	113	Alternative sequence	ID=VSP_055454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	44	54	52	52	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24870230;Dbxref=PMID:24870230
DDX1	Q92499	44	54	52	52	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24870230;Dbxref=PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	102	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	120	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	120	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX43	Q9NXZ2	145	189	1	648	Chain	ID=PRO_0000054972;Note=Probable ATP-dependent RNA helicase DDX43
DDX46	Q7L014	6	68	2	1031	Chain	ID=PRO_0000055121;Note=Probable ATP-dependent RNA helicase DDX46
DDX46	Q7L014	69	116	2	1031	Chain	ID=PRO_0000055121;Note=Probable ATP-dependent RNA helicase DDX46
DDX46	Q7L014	6	68	3	103	Compositional bias	Note=Arg-rich
DDX46	Q7L014	69	116	3	103	Compositional bias	Note=Arg-rich
DDX46	Q7L014	69	116	109	109	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX46	Q7L014	69	116	114	114	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND6A	Q8IWF6	421	451	1	608	Chain	ID=PRO_0000289116;Note=Protein DENND6A
DENND6A	Q8IWF6	233	254	1	608	Chain	ID=PRO_0000289116;Note=Protein DENND6A
DENND6A	Q8IWF6	233	254	63	247	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND6A	Q8IWF6	421	451	395	528	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DPF1	Q92782	225	242	1	380	Chain	ID=PRO_0000168145;Note=Zinc finger protein neuro-d4
DPF1	Q92782	225	242	226	226	Alternative sequence	ID=VSP_040225;Note=In isoform 2 and isoform 3. K->ICGKRYKNRPGLSYHYTHTHLAEEEGEENAERHALPFHRKNNHKQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DOCK6	Q96HP0	1648	1696	1	2047	Chain	ID=PRO_0000189993;Note=Dedicator of cytokinesis protein 6
DOCK6	Q96HP0	1446	1497	1	2047	Chain	ID=PRO_0000189993;Note=Dedicator of cytokinesis protein 6
DOCK6	Q96HP0	906	938	1	2047	Chain	ID=PRO_0000189993;Note=Dedicator of cytokinesis protein 6
DOCK6	Q96HP0	691	720	1	2047	Chain	ID=PRO_0000189993;Note=Dedicator of cytokinesis protein 6
DOCK6	Q96HP0	291	341	1	2047	Chain	ID=PRO_0000189993;Note=Dedicator of cytokinesis protein 6
DOCK6	Q96HP0	691	720	548	714	Domain	Note=DHR-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00983
DOCK6	Q96HP0	1648	1696	1587	2023	Domain	Note=DHR-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00984
DPM2	O94777	1	31	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10835346;Dbxref=PMID:10835346
DPM2	O94777	1	31	2	84	Chain	ID=PRO_0000220873;Note=Dolichol phosphate-mannose biosynthesis regulatory protein
DPM2	O94777	1	31	11	31	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPM2	O94777	1	31	23	23	Natural variant	ID=VAR_069745;Note=In CDG1U. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23109149;Dbxref=dbSNP:rs397514503,PMID:23109149
GAS8	O95995	1	30	1	478	Chain	ID=PRO_0000220377;Note=Dynein regulatory complex subunit 4
GAS8	O95995	308	337	1	478	Chain	ID=PRO_0000220377;Note=Dynein regulatory complex subunit 4
GAS8	O95995	1	30	1	114	Region	Note=Regulates microtubule-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60779
GAS8	O95995	308	337	242	427	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GAS8	O95995	1	30	1	25	Alternative sequence	ID=VSP_054805;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GAS8	O95995	308	337	183	478	Natural variant	ID=VAR_080336;Note=In CILD33%3B loss of localization to cilia%3B abnormal cilia with axonemal disorganization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120127;Dbxref=PMID:27120127
GAS8	O95995	308	337	334	478	Natural variant	ID=VAR_080337;Note=In CILD33%3B loss of localization to cilia%3B abnormal cilia with axonemal disorganization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27120127;Dbxref=PMID:27120127
DPYSL5	Q9BPU6	140	200	1	564	Chain	ID=PRO_0000165924;Note=Dihydropyrimidinase-related protein 5
DPYSL5	Q9BPU6	140	200	1	564	Chain	ID=PRO_0000165924;Note=Dihydropyrimidinase-related protein 5
DPYSL5	Q9BPU6	140	200	139	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	139	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	156	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	156	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	171	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	171	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	187	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	187	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DPYSL5	Q9BPU6	140	200	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B91
DSN1	Q9H410	11	118	1	356	Chain	ID=PRO_0000079481;Note=Kinetochore-associated protein DSN1 homolog
DSN1	Q9H410	11	118	1	356	Chain	ID=PRO_0000079481;Note=Kinetochore-associated protein DSN1 homolog
DSN1	Q9H410	11	118	28	28	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DSN1	Q9H410	11	118	28	28	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DSN1	Q9H410	11	118	30	30	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
DSN1	Q9H410	11	118	30	30	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
DSN1	Q9H410	11	118	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
DSN1	Q9H410	11	118	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
DSN1	Q9H410	11	118	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
DSN1	Q9H410	11	118	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
DSN1	Q9H410	11	118	81	81	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
DSN1	Q9H410	11	118	81	81	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
DSN1	Q9H410	11	118	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DSN1	Q9H410	11	118	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DSN1	Q9H410	11	118	1	84	Alternative sequence	ID=VSP_003826;Note=In isoform 2. MTSVTRSEIIDEKGPVMSKTHDHQLESSLSPVEVFAKTSASLEMNQGVSEERIHLGSSPKKGGNCDLSHQERLQSKSLHLSPQE->MIINWNQVSVLWKCLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DSN1	Q9H410	11	118	1	84	Alternative sequence	ID=VSP_003826;Note=In isoform 2. MTSVTRSEIIDEKGPVMSKTHDHQLESSLSPVEVFAKTSASLEMNQGVSEERIHLGSSPKKGGNCDLSHQERLQSKSLHLSPQE->MIINWNQVSVLWKCLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DSN1	Q9H410	11	118	1	16	Alternative sequence	ID=VSP_044281;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DSN1	Q9H410	11	118	1	16	Alternative sequence	ID=VSP_044281;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DSN1	Q9H410	11	118	12	118	Alternative sequence	ID=VSP_043204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DSN1	Q9H410	11	118	12	118	Alternative sequence	ID=VSP_043204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DTNBP1	Q96EV8	170	222	1	351	Chain	ID=PRO_0000191001;Note=Dysbindin
DTNBP1	Q96EV8	37	53	1	351	Chain	ID=PRO_0000191001;Note=Dysbindin
DTNBP1	Q96EV8	170	222	173	331	Region	Note=Dysbindin
DTNBP1	Q96EV8	170	222	88	181	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DTNBP1	Q96EV8	37	53	1	81	Alternative sequence	ID=VSP_046062;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DTNBP1	Q96EV8	170	222	214	214	Natural variant	ID=VAR_053069;Note=G->D;Dbxref=dbSNP:rs16876589
DTNBP1	Q96EV8	170	222	215	215	Mutagenesis	Note=Reduced interaction with AP3M1. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19428785;Dbxref=PMID:19428785
DSG2	Q14126	72	126	50	1118	Chain	ID=PRO_0000003846;Note=Desmoglein-2
DSG2	Q14126	230	276	50	1118	Chain	ID=PRO_0000003846;Note=Desmoglein-2
DSG2	Q14126	72	126	50	609	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSG2	Q14126	230	276	50	609	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSG2	Q14126	72	126	50	160	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSG2	Q14126	230	276	161	273	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSG2	Q14126	230	276	274	388	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSG2	Q14126	72	126	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:19159218
DSG2	Q14126	72	126	89	89	Natural variant	ID=VAR_048508;Note=Y->C;Dbxref=dbSNP:rs2230232
DSG2	Q14126	72	126	76	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	95	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	100	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	119	121	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	72	126	123	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	230	276	229	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	230	276	233	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DSG2	Q14126	230	276	257	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ERD
DNAJC3	Q13217	131	182	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
DNAJC3	Q13217	243	282	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
DNAJC3	Q13217	131	182	105	138	Repeat	Note=TPR 3
DNAJC3	Q13217	131	182	154	187	Repeat	Note=TPR 4
DNAJC3	Q13217	243	282	222	255	Repeat	Note=TPR 6
DNAJC3	Q13217	243	282	268	301	Repeat	Note=TPR 7
DNAJC3	Q13217	243	282	274	274	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
DNAJC3	Q13217	243	282	248	258	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21799829;Dbxref=PMID:21799829
DNAJC3	Q13217	131	182	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	131	182	138	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	131	182	170	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	243	282	238	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	243	282	256	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DPEP3	Q9H4B8	277	336	36	463	Chain	ID=PRO_0000231609;Note=Dipeptidase 3
DPEP3	Q9H4B8	277	336	290	290	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10073
DPEP3	Q9H4B8	277	336	334	334	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPEP3	Q9H4B8	277	336	297	329	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10073
DPEP3	Q9H4B8	277	336	312	312	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLG	P54098	994	1034	1	1239	Chain	ID=PRO_0000101270;Note=DNA polymerase subunit gamma-1
POLG	P54098	719	755	1	1239	Chain	ID=PRO_0000101270;Note=DNA polymerase subunit gamma-1
POLG	P54098	994	1034	1	1239	Chain	ID=PRO_0000101270;Note=DNA polymerase subunit gamma-1
POLG	P54098	719	755	1	1239	Chain	ID=PRO_0000101270;Note=DNA polymerase subunit gamma-1
POLG	P54098	719	755	737	737	Natural variant	ID=VAR_058885;Note=In PEOB1%3B with absence of progressive external ophthalmoplegia. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16634032;Dbxref=dbSNP:rs121918054,PMID:16634032
POLG	P54098	719	755	737	737	Natural variant	ID=VAR_058885;Note=In PEOB1%3B with absence of progressive external ophthalmoplegia. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16634032;Dbxref=dbSNP:rs121918054,PMID:16634032
POLG	P54098	719	755	748	748	Natural variant	ID=VAR_023673;Note=In SANDO%2C SCAE and MTDPS4A%3B unknown pathological significance. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15477547,ECO:0000269|PubMed:15824347,ECO:0000269|PubMed:15929042,ECO:0000269|PubMed:16080118,ECO:0000269|PubMed:16639411,ECO:0000269|PubMed:18828154;Dbxref=dbSNP:rs113994097,PMID:15477547,PMID:15824347,PMID:15929042,PMID:16080118,PMID:16639411,PMID:18828154
POLG	P54098	719	755	748	748	Natural variant	ID=VAR_023673;Note=In SANDO%2C SCAE and MTDPS4A%3B unknown pathological significance. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15477547,ECO:0000269|PubMed:15824347,ECO:0000269|PubMed:15929042,ECO:0000269|PubMed:16080118,ECO:0000269|PubMed:16639411,ECO:0000269|PubMed:18828154;Dbxref=dbSNP:rs113994097,PMID:15477547,PMID:15824347,PMID:15929042,PMID:16080118,PMID:16639411,PMID:18828154
POLG	P54098	719	755	716	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	719	755	716	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	719	755	738	740	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	719	755	738	740	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	719	755	743	745	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZTU
POLG	P54098	719	755	743	745	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZTU
POLG	P54098	719	755	755	757	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	719	755	755	757	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	992	995	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	992	995	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	997	999	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	997	999	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1001	1009	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1001	1009	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1010	1013	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1010	1013	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1027	1030	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1027	1030	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1033	1035	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
POLG	P54098	994	1034	1033	1035	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKM
DHRS7C	A6NNS2	191	243	19	312	Chain	ID=PRO_0000333755;Note=Dehydrogenase/reductase SDR family member 7C
DHRS7C	A6NNS2	191	243	192	192	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
DHRS7C	A6NNS2	191	243	227	227	Natural variant	ID=VAR_043150;Note=S->L;Dbxref=dbSNP:rs2280490
DPYSL4	O14531	180	207	1	572	Chain	ID=PRO_0000165921;Note=Dihydropyrimidinase-related protein 4
DPYSL4	O14531	207	230	1	572	Chain	ID=PRO_0000165921;Note=Dihydropyrimidinase-related protein 4
DPYSL4	O14531	427	487	1	572	Chain	ID=PRO_0000165921;Note=Dihydropyrimidinase-related protein 4
DPYSL4	O14531	180	207	178	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	180	207	194	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	180	207	202	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	207	230	202	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	207	230	220	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	207	230	229	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	427	487	426	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	427	487	433	436	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	427	487	438	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	427	487	451	455	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DPYSL4	O14531	427	487	476	491	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NKS
DSG1	Q02413	228	273	50	1049	Chain	ID=PRO_0000003838;Note=Desmoglein-1
DSG1	Q02413	228	273	50	548	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DSG1	Q02413	228	273	159	270	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSG1	Q02413	228	273	271	385	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DSG1	Q02413	228	273	1	641	Alternative sequence	ID=VSP_055930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPD1	P21695	204	282	1	349	Chain	ID=PRO_0000138079;Note=Glycerol-3-phosphate dehydrogenase [NAD(+)]%2C cytoplasmic
GPD1	P21695	204	282	269	270	Region	Note=Substrate binding
GPD1	P21695	204	282	204	204	Active site	Note=Proton acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPD1	P21695	204	282	269	269	Binding site	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16460752;Dbxref=PMID:16460752
GPD1	P21695	204	282	223	223	Natural variant	ID=VAR_067426;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22226083;Dbxref=dbSNP:rs200251017,PMID:22226083
GPD1	P21695	204	282	229	229	Natural variant	ID=VAR_071967;Note=In HTGTI. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24549054;Dbxref=dbSNP:rs199673455,PMID:24549054
GPD1	P21695	204	282	194	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
GPD1	P21695	204	282	221	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
GPD1	P21695	204	282	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
GPD1	P21695	204	282	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
GPD1	P21695	204	282	255	257	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
GPD1	P21695	204	282	258	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
GPD1	P21695	204	282	269	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0V
DTX1	Q86Y01	409	462	1	620	Chain	ID=PRO_0000219080;Note=E3 ubiquitin-protein ligase DTX1
DTX1	Q86Y01	409	462	411	472	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
IFIH1	Q9BYX4	508	547	1	1025	Chain	ID=PRO_0000102012;Note=Interferon-induced helicase C domain-containing protein 1
IFIH1	Q9BYX4	207	256	1	1025	Chain	ID=PRO_0000102012;Note=Interferon-induced helicase C domain-containing protein 1
IFIH1	Q9BYX4	508	547	316	509	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
IFIH1	Q9BYX4	207	256	208	209	Site	Note=Cleavage;Ontology_term=ECO:0000250;evidence=ECO:0000250
IFIH1	Q9BYX4	207	256	216	217	Site	Note=Cleavage;Ontology_term=ECO:0000250;evidence=ECO:0000250
IFIH1	Q9BYX4	207	256	251	252	Site	Note=Cleavage;Ontology_term=ECO:0000250;evidence=ECO:0000250
IFIH1	Q9BYX4	207	256	208	221	Alternative sequence	ID=VSP_013337;Note=In isoform 2. EIENLSQVDGPQVE->GICNFTEEDSSNSA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFIH1	Q9BYX4	508	547	222	1025	Alternative sequence	ID=VSP_013338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFIH1	Q9BYX4	207	256	222	1025	Alternative sequence	ID=VSP_013338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IFIH1	Q9BYX4	207	256	251	251	Mutagenesis	Note=No cleavage and no acceleration of DNA degradation. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12015121;Dbxref=PMID:12015121
IGDCC3	Q8IVU1	465	520	36	814	Chain	ID=PRO_0000014920;Note=Immunoglobulin superfamily DCC subclass member 3
IGDCC3	Q8IVU1	228	274	36	814	Chain	ID=PRO_0000014920;Note=Immunoglobulin superfamily DCC subclass member 3
IGDCC3	Q8IVU1	465	520	36	640	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGDCC3	Q8IVU1	228	274	36	640	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGDCC3	Q8IVU1	228	274	238	321	Domain	Note=Ig-like C2-type 3
IGDCC3	Q8IVU1	465	520	426	520	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IGDCC3	Q8IVU1	228	274	246	246	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGDCC3	Q8IVU1	228	274	259	307	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IPP	Q9Y573	349	395	1	584	Chain	ID=PRO_0000119075;Note=Actin-binding protein IPP
IPP	Q9Y573	349	395	344	390	Repeat	Note=Kelch 2
IPP	Q9Y573	349	395	391	437	Repeat	Note=Kelch 3
IRF1	P10914	181	222	1	325	Chain	ID=PRO_0000154545;Note=Interferon regulatory factor 1
IRF1	P10914	181	222	1	325	Chain	ID=PRO_0000154545;Note=Interferon regulatory factor 1
IRF1	P10914	181	222	220	220	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
IRF1	P10914	181	222	220	220	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
IRF1	P10914	181	222	220	220	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
IRF1	P10914	181	222	220	220	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
IQGAP2	Q13576	101	127	1	1575	Chain	ID=PRO_0000056650;Note=Ras GTPase-activating-like protein IQGAP2
IQGAP2	Q13576	641	698	1	1575	Chain	ID=PRO_0000056650;Note=Ras GTPase-activating-like protein IQGAP2
IQGAP2	Q13576	1456	1501	1	1575	Chain	ID=PRO_0000056650;Note=Ras GTPase-activating-like protein IQGAP2
IQGAP2	Q13576	101	127	41	156	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
IQGAP2	Q13576	641	698	690	719	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP2	Q13576	641	698	685	685	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
IQGAP2	Q13576	1456	1501	1461	1461	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
IQGAP2	Q13576	101	127	1	447	Alternative sequence	ID=VSP_010629;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
IQGAP2	Q13576	641	698	642	698	Alternative sequence	ID=VSP_010631;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
IQGAP2	Q13576	1456	1501	1479	1482	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEZ
IQGAP2	Q13576	1456	1501	1483	1488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEZ
IQGAP2	Q13576	1456	1501	1491	1495	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEZ
IQGAP2	Q13576	1456	1501	1500	1505	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IEZ
IDE	P14735	829	920	1	1019	Chain	ID=PRO_0000074404;Note=Insulin-degrading enzyme
IDE	P14735	773	829	1	1019	Chain	ID=PRO_0000074404;Note=Insulin-degrading enzyme
IDE	P14735	511	552	1	1019	Chain	ID=PRO_0000074404;Note=Insulin-degrading enzyme
IDE	P14735	220	261	1	1019	Chain	ID=PRO_0000074404;Note=Insulin-degrading enzyme
IDE	P14735	829	920	895	901	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
IDE	P14735	829	920	853	858	Motif	Note=SlyX motif
IDE	P14735	511	552	1	555	Alternative sequence	ID=VSP_044303;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IDE	P14735	220	261	1	555	Alternative sequence	ID=VSP_044303;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IDE	P14735	773	829	817	817	Mutagenesis	Note=Increases catalytic rate towards INS and amyloid%3B when associated with C-132. E->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17051221;Dbxref=PMID:17051221
IDE	P14735	773	829	828	828	Mutagenesis	Note=Increases catalytic rate towards INS and amyloid%3B when associated with C-184. Q->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17051221;Dbxref=PMID:17051221
IDE	P14735	829	920	831	831	Mutagenesis	Note=No effect on catalytic activity. Y->F
IDE	P14735	829	920	899	899	Mutagenesis	Note=Increases catalytic rate towards INS and amyloid%3B when associated with C-426. K->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17051221,ECO:0000269|PubMed:17613531;Dbxref=PMID:17051221,PMID:17613531
IDE	P14735	829	920	845	845	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IDE	P14735	220	261	223	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	220	261	228	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	220	261	237	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	220	261	251	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	220	261	254	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	511	552	507	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	511	552	549	553	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	773	829	775	782	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	773	829	787	799	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	773	829	802	823	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	773	829	824	827	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	829	920	831	840	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	829	920	843	854	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	829	920	856	876	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	829	920	879	894	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	829	920	900	912	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
IDE	P14735	829	920	920	928	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CWW
MDH2	P40926	78	106	25	338	Chain	ID=PRO_0000018628;Note=Malate dehydrogenase%2C mitochondrial
MDH2	P40926	143	185	25	338	Chain	ID=PRO_0000018628;Note=Malate dehydrogenase%2C mitochondrial
MDH2	P40926	78	106	104	104	Binding site	Note=Substrate;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10004,ECO:0000269|Ref.16
MDH2	P40926	143	185	176	176	Binding site	Note=Substrate;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10004,ECO:0000269|Ref.16
MDH2	P40926	78	106	78	78	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08249
MDH2	P40926	78	106	78	78	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08249
MDH2	P40926	78	106	91	91	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08249
MDH2	P40926	78	106	91	91	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08249
MDH2	P40926	143	185	165	165	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
MDH2	P40926	143	185	185	185	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19608861,ECO:0000269|PubMed:20167786;Dbxref=PMID:19608861,PMID:20167786
MDH2	P40926	143	185	185	185	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08249
MDH2	P40926	143	185	144	185	Alternative sequence	ID=VSP_055312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MDH2	P40926	143	185	185	185	Mutagenesis	Note=No activation of enzyme activity on treatment with TSA or NAM%3B when associated with R-301%3B R-307 and R-314. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
MDH2	P40926	78	106	76	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
MDH2	P40926	78	106	83	85	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
MDH2	P40926	78	106	86	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
MDH2	P40926	78	106	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
MDH2	P40926	143	185	144	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
MDH2	P40926	143	185	165	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
MDH2	P40926	143	185	171	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DFD
IGF2BP2	Q9Y6M1	444	488	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
IGF2BP2	Q9Y6M1	419	444	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
IGF2BP2	Q9Y6M1	135	225	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
IGF2BP2	Q9Y6M1	135	225	82	157	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
IGF2BP2	Q9Y6M1	135	225	193	258	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP2	Q9Y6M1	444	488	427	492	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP2	Q9Y6M1	419	444	427	492	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP2	Q9Y6M1	135	225	162	162	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
IGF2BP2	Q9Y6M1	135	225	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
IGF2BP2	Q9Y6M1	135	225	211	211	Mutagenesis	Note=Significantly impaired binding to ACTB transcript%2C but little effect on MYC transcript binding%2C accumulation in the nucleus%3B when associated with E-292. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C almost complete loss of ACTB and MYC transcript binding%2C almost complete loss of ELAVL1-%2C DHX9- and HNRNPU-binding and perturbed subcellular location%2C including accumulation in the nucleus and loss of localization to stress granules%3B when associated with E-292%3B 445-E-E-446 and 526-E-E-527. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23640942;Dbxref=PMID:23640942
IGF2BP2	Q9Y6M1	444	488	445	446	Mutagenesis	Note=Significantly impaired binding to ACTB and MYC transcripts%3B when associated with 527-E-E-528. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C almost complete loss of ACTB and MYC transcript binding%2C almost complete loss of ELAVL1-%2C DHX9- and HNRNPU-binding and perturbed subcellular location%2C including accumulation in the nucleus and loss of localization to stress granules%3B when associated with E-211%3B E-292 and 527-E-E-528. KK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23640942;Dbxref=PMID:23640942
IGF2BP3	O00425	401	440	1	579	Chain	ID=PRO_0000282538;Note=Insulin-like growth factor 2 mRNA-binding protein 3
IGF2BP3	O00425	401	440	405	470	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP3	O00425	401	440	423	424	Mutagenesis	Note=Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C Modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-%2C DHX9- and HNRNPU-binding%2C nor on subcellular location%3B when associated with E-213%3B E-294 and 505-E-E-506. KQ->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23640942;Dbxref=PMID:23640942
IGF2BP3	O00425	401	440	410	410	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2BP3	O00425	401	440	410	410	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGSF8	Q969P0	21	147	1	27	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19892738;Dbxref=PMID:19892738
IGSF8	Q969P0	301	437	28	613	Chain	ID=PRO_0000226247;Note=Immunoglobulin superfamily member 8
IGSF8	Q969P0	301	437	28	613	Chain	ID=PRO_0000226247;Note=Immunoglobulin superfamily member 8
IGSF8	Q969P0	21	147	28	613	Chain	ID=PRO_0000226247;Note=Immunoglobulin superfamily member 8
IGSF8	Q969P0	301	437	28	579	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF8	Q969P0	301	437	28	579	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF8	Q969P0	21	147	28	579	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF8	Q969P0	21	147	28	149	Domain	Note=Ig-like C2-type 1
IGSF8	Q969P0	301	437	303	424	Domain	Note=Ig-like C2-type 3
IGSF8	Q969P0	301	437	303	424	Domain	Note=Ig-like C2-type 3
IGSF8	Q969P0	301	437	431	560	Domain	Note=Ig-like C2-type 4
IGSF8	Q969P0	301	437	431	560	Domain	Note=Ig-like C2-type 4
IGSF8	Q969P0	21	147	50	50	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF8	Q969P0	301	437	327	327	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
IGSF8	Q969P0	301	437	327	327	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
IGSF8	Q969P0	21	147	49	127	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF8	Q969P0	301	437	326	406	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF8	Q969P0	301	437	326	406	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF8	Q969P0	21	147	1	241	Alternative sequence	ID=VSP_017429;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IGSF8	Q969P0	301	437	242	315	Alternative sequence	ID=VSP_017430;Note=In isoform 2. ELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERR->MRGRSWHWAAWRGQAHRSTHTWQCPLGDLCPRHQLGGQLCRKWWESGQTWPWRLELPMLSDWLQGSFVWARKGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IGSF8	Q969P0	301	437	242	315	Alternative sequence	ID=VSP_017430;Note=In isoform 2. ELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERR->MRGRSWHWAAWRGQAHRSTHTWQCPLGDLCPRHQLGGQLCRKWWESGQTWPWRLELPMLSDWLQGSFVWARKGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IGSF8	Q969P0	301	437	303	303	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGSF8	Q969P0	301	437	303	303	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGSF8	Q969P0	301	437	306	306	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGSF8	Q969P0	301	437	306	306	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFRD2	Q12894	182	199	1	506	Chain	ID=PRO_0000153289;Note=Interferon-related developmental regulator 2
IPO5	O00410	30	57	2	1097	Chain	ID=PRO_0000120771;Note=Importin-5
IPO5	O00410	831	872	2	1097	Chain	ID=PRO_0000120771;Note=Importin-5
IPO5	O00410	30	57	5	38	Repeat	Note=HEAT 1;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P32337,ECO:0000305|PubMed:23541588;Dbxref=PMID:23541588
IPO5	O00410	30	57	28	99	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
IPO5	O00410	30	57	43	77	Repeat	Note=HEAT 2;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P32337,ECO:0000305|PubMed:23541588;Dbxref=PMID:23541588
IPO5	O00410	831	872	787	853	Repeat	Note=HEAT 18;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P32337,ECO:0000305|PubMed:23541588;Dbxref=PMID:23541588
IPO5	O00410	831	872	856	895	Repeat	Note=HEAT 19;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P32337,ECO:0000305|PubMed:23541588;Dbxref=PMID:23541588
IPO5	O00410	30	57	1	60	Alternative sequence	ID=VSP_037587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ITPKA	P23677	336	370	1	461	Chain	ID=PRO_0000066865;Note=Inositol-trisphosphate 3-kinase A
ITPKA	P23677	336	370	336	336	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1W2C,ECO:0000269|PubMed:15350214;Dbxref=PMID:15350214
ITPKA	P23677	336	370	329	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W2F
ITPKA	P23677	336	370	338	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W2D
ITPKA	P23677	336	370	352	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W2F
ITPKA	P23677	336	370	367	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W2F
IQSEC1	Q6DN90	734	744	1	963	Chain	ID=PRO_0000245606;Note=IQ motif and SEC7 domain-containing protein 1
IRF8	Q02556	200	329	1	426	Chain	ID=PRO_0000154564;Note=Interferon regulatory factor 8
APOO	Q9BUR5	160	187	26	198	Chain	ID=PRO_0000254646;Note=MICOS complex subunit MIC26
APOO	Q9BUR5	97	129	26	198	Chain	ID=PRO_0000254646;Note=MICOS complex subunit MIC26
APOO	Q9BUR5	97	129	108	128	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
APOO	Q9BUR5	160	187	162	162	Glycosylation	Note=O-linked (Xyl...) (chondroitin sulfate) serine;Ontology_term=ECO:0000255;evidence=ECO:0000255
APOO	Q9BUR5	97	129	80	109	Alternative sequence	ID=VSP_023333;Note=In isoform 2. ETYSQTKPKMQSLVQWGLDSYDYLQNAPPG->TAMTISKMHLLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
IMPAD1	Q9NX62	215	269	1	359	Chain	ID=PRO_0000289041;Note=Inositol monophosphatase 3
IMPAD1	Q9NX62	183	215	1	359	Chain	ID=PRO_0000289041;Note=Inositol monophosphatase 3
IMPAD1	Q9NX62	215	269	34	359	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IMPAD1	Q9NX62	183	215	34	359	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
IMPAD1	Q9NX62	215	269	259	259	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:18695242;Dbxref=PMID:18695242
IMPAD1	Q9NX62	183	215	183	183	Natural variant	ID=VAR_065848;Note=In CDP-GPAPP. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549340;Dbxref=dbSNP:rs387907102,PMID:21549340
IMPDH2	P12268	480	507	2	514	Chain	ID=PRO_0000093673;Note=Inosine-5'-monophosphate dehydrogenase 2
IMPDH2	P12268	432	479	2	514	Chain	ID=PRO_0000093673;Note=Inosine-5'-monophosphate dehydrogenase 2
IMPDH2	P12268	335	383	2	514	Chain	ID=PRO_0000093673;Note=Inosine-5'-monophosphate dehydrogenase 2
IMPDH2	P12268	108	177	2	514	Chain	ID=PRO_0000093673;Note=Inosine-5'-monophosphate dehydrogenase 2
IMPDH2	P12268	83	108	2	514	Chain	ID=PRO_0000093673;Note=Inosine-5'-monophosphate dehydrogenase 2
IMPDH2	P12268	108	177	114	173	Domain	Note=CBS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03156
IMPDH2	P12268	335	383	364	366	Region	Note=IMP binding
IMPDH2	P12268	480	507	500	500	Metal binding	Note=Potassium%3B via carbonyl oxygen%3B shared with tetrameric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03156
IMPDH2	P12268	480	507	501	501	Metal binding	Note=Potassium%3B via carbonyl oxygen%3B shared with tetrameric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03156
IMPDH2	P12268	480	507	502	502	Metal binding	Note=Potassium%3B via carbonyl oxygen%3B shared with tetrameric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03156
IMPDH2	P12268	432	479	441	441	Binding site	Note=IMP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03156
IMPDH2	P12268	108	177	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
IMPDH2	P12268	108	177	160	160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
IMPDH2	P12268	432	479	438	438	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
IMPDH2	P12268	83	108	77	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	83	108	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3O
IMPDH2	P12268	108	177	97	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	83	108	97	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	108	177	109	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3O
IMPDH2	P12268	108	177	123	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3O
IMPDH2	P12268	108	177	142	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3O
IMPDH2	P12268	108	177	152	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3O
IMPDH2	P12268	108	177	161	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	108	177	175	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	335	383	333	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	335	383	343	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	335	383	355	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	335	383	361	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	335	383	370	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	335	383	382	387	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	432	479	444	447	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	432	479	453	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	480	507	476	484	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	432	479	476	484	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	480	507	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
IMPDH2	P12268	480	507	495	501	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NF7
INO80E	Q8NBZ0	132	171	1	244	Chain	ID=PRO_0000234292;Note=INO80 complex subunit E
INO80E	Q8NBZ0	132	171	91	211	Compositional bias	Note=Pro-rich
INO80E	Q8NBZ0	132	171	159	159	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
INO80E	Q8NBZ0	132	171	171	171	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
INO80E	Q8NBZ0	132	171	133	244	Alternative sequence	ID=VSP_055984;Note=In isoform 2. LASSRYPPFPSDYLALQLPEPSPLRPKREKRPRLPRKLKMAVGPPDCPVGGPLTFPGRGSGAGVGTTLTPLPPPKMPPPTILSTVPRQMFSDAGSGDDALDGDDDLVIDIPE->ERGQA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
IFNAR2	P48551	18	32	1	26	Signal peptide	.
IFNAR2	P48551	18	32	27	515	Chain	ID=PRO_0000011006;Note=Interferon alpha/beta receptor 2
IFNAR2	P48551	18	32	27	243	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
INPP4B	O15327	453	521	1	924	Chain	ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase
INPP4B	O15327	124	141	1	924	Chain	ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase
INPP4B	O15327	453	521	1	924	Chain	ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase
INPP4B	O15327	124	141	1	924	Chain	ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase
INPP4B	O15327	453	521	1	924	Chain	ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase
INPP4B	O15327	124	141	1	924	Chain	ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase
INPP4B	O15327	124	141	25	149	Domain	Note=C2
INPP4B	O15327	124	141	25	149	Domain	Note=C2
INPP4B	O15327	124	141	25	149	Domain	Note=C2
INPP4B	O15327	124	141	125	131	Alternative sequence	ID=VSP_047696;Note=In isoform 2. VRTSVLP->IANSSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	124	141	125	131	Alternative sequence	ID=VSP_047696;Note=In isoform 2. VRTSVLP->IANSSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	124	141	125	131	Alternative sequence	ID=VSP_047696;Note=In isoform 2. VRTSVLP->IANSSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	453	521	132	924	Alternative sequence	ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	124	141	132	924	Alternative sequence	ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	453	521	132	924	Alternative sequence	ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	124	141	132	924	Alternative sequence	ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	453	521	132	924	Alternative sequence	ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP4B	O15327	124	141	132	924	Alternative sequence	ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
INPP5E	Q9NRR6	426	462	1	641	Chain	ID=PRO_0000209747;Note=72 kDa inositol polyphosphate 5-phosphatase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24166846;Dbxref=PMID:24166846
INPP5E	Q9NRR6	386	426	1	641	Chain	ID=PRO_0000209747;Note=72 kDa inositol polyphosphate 5-phosphatase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24166846;Dbxref=PMID:24166846
INPP5E	Q9NRR6	426	462	426	426	Natural variant	ID=VAR_077250;Note=In JBTS1. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23386033;Dbxref=PMID:23386033
INPP5E	Q9NRR6	386	426	426	426	Natural variant	ID=VAR_077250;Note=In JBTS1. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23386033;Dbxref=PMID:23386033
INPP5E	Q9NRR6	426	462	435	435	Natural variant	ID=VAR_063013;Note=In JBTS1%3B severe reduction of activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19668216,ECO:0000269|PubMed:23386033;Dbxref=dbSNP:rs121918129,PMID:19668216,PMID:23386033
INPP5E	Q9NRR6	386	426	389	399	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	386	426	402	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	386	426	416	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	426	462	432	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	426	462	450	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	426	462	457	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INSR	P06213	744	755	28	758	Chain	ID=PRO_0000016687;Note=Insulin receptor subunit alpha
INSR	P06213	620	676	28	758	Chain	ID=PRO_0000016687;Note=Insulin receptor subunit alpha
INSR	P06213	744	755	28	758	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
INSR	P06213	620	676	28	758	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
INSR	P06213	620	676	624	726	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
INSR	P06213	620	676	633	633	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
INSR	P06213	620	676	651	651	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
INSR	P06213	744	755	674	899	Disulfide bond	.
INSR	P06213	620	676	674	899	Disulfide bond	.
INSR	P06213	744	755	745	756	Alternative sequence	ID=VSP_002898;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2983222,ECO:0000303|Ref.13;Dbxref=PMID:15489334,PMID:2983222
INSR	P06213	620	676	635	635	Natural variant	ID=VAR_079539;Note=In RMS%3B decreases post-translational processing. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28765322;Dbxref=PMID:28765322
INSR	P06213	620	676	657	657	Natural variant	ID=VAR_079540;Note=In LEPRCH%3B impairs post-translational processing. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28765322;Dbxref=PMID:28765322
INSR	P06213	620	676	659	659	Natural variant	ID=VAR_079541;Note=In LEPRCH%3B impairs post-translational processing. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28765322;Dbxref=PMID:28765322
INSR	P06213	620	676	626	631	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZXB
INSR	P06213	620	676	633	636	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZXB
INSR	P06213	620	676	638	643	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZXB
INSR	P06213	620	676	654	658	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZXB
INSR	P06213	620	676	666	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZXB
INTS12	Q96CB8	219	268	1	462	Chain	ID=PRO_0000059312;Note=Integrator complex subunit 12
INTS12	Q96CB8	52	103	1	462	Chain	ID=PRO_0000059312;Note=Integrator complex subunit 12
INTS12	Q96CB8	219	268	1	462	Chain	ID=PRO_0000059312;Note=Integrator complex subunit 12
INTS12	Q96CB8	52	103	1	462	Chain	ID=PRO_0000059312;Note=Integrator complex subunit 12
INTS12	Q96CB8	219	268	1	462	Chain	ID=PRO_0000059312;Note=Integrator complex subunit 12
INTS12	Q96CB8	52	103	1	462	Chain	ID=PRO_0000059312;Note=Integrator complex subunit 12
INTS12	Q96CB8	52	103	68	68	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
INTS12	Q96CB8	52	103	68	68	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
INTS12	Q96CB8	52	103	68	68	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
INTS12	Q96CB8	219	268	254	254	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
INTS12	Q96CB8	219	268	254	254	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
INTS12	Q96CB8	219	268	254	254	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
INTS8	Q75QN2	102	148	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	149	172	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	190	251	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	251	287	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	287	339	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	547	584	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	879	896	1	995	Chain	ID=PRO_0000259553;Note=Integrator complex subunit 8
INTS8	Q75QN2	190	251	250	288	Repeat	Note=TPR 1
INTS8	Q75QN2	251	287	250	288	Repeat	Note=TPR 1
INTS8	Q75QN2	287	339	250	288	Repeat	Note=TPR 1
INTS8	Q75QN2	287	339	320	356	Repeat	Note=TPR 2
INTS8	Q75QN2	547	584	570	603	Repeat	Note=TPR 3
INTS8	Q75QN2	879	896	879	895	Alternative sequence	ID=VSP_021469;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
INTS4	Q96HW7	743	762	1	963	Chain	ID=PRO_0000259538;Note=Integrator complex subunit 4
INTS4	Q96HW7	672	699	1	963	Chain	ID=PRO_0000259538;Note=Integrator complex subunit 4
INTS4	Q96HW7	306	330	1	963	Chain	ID=PRO_0000259538;Note=Integrator complex subunit 4
INTS4	Q96HW7	219	236	1	963	Chain	ID=PRO_0000259538;Note=Integrator complex subunit 4
INTS4	Q96HW7	18	82	1	963	Chain	ID=PRO_0000259538;Note=Integrator complex subunit 4
INTS4	Q96HW7	18	82	66	105	Repeat	Note=HEAT 1
INTS4	Q96HW7	219	236	190	228	Repeat	Note=HEAT 3
INTS4	Q96HW7	219	236	229	263	Repeat	Note=HEAT 4
INTS4	Q96HW7	306	330	277	313	Repeat	Note=HEAT 5
INTS4	Q96HW7	18	82	26	26	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CIM8
INTS4	Q96HW7	306	330	1	626	Alternative sequence	ID=VSP_021447;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
INTS4	Q96HW7	219	236	1	626	Alternative sequence	ID=VSP_021447;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
INTS4	Q96HW7	18	82	1	626	Alternative sequence	ID=VSP_021447;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
INTS4	Q96HW7	18	82	1	148	Alternative sequence	ID=VSP_021448;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS4	Q96HW7	743	762	506	963	Alternative sequence	ID=VSP_021450;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS4	Q96HW7	672	699	506	963	Alternative sequence	ID=VSP_021450;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS4	Q96HW7	743	762	660	963	Alternative sequence	ID=VSP_021453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS4	Q96HW7	672	699	660	963	Alternative sequence	ID=VSP_021453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IQCE	Q6IPM2	86	131	1	695	Chain	ID=PRO_0000284110;Note=IQ domain-containing protein E
IQCE	Q6IPM2	415	449	1	695	Chain	ID=PRO_0000284110;Note=IQ domain-containing protein E
IQCE	Q6IPM2	544	581	1	695	Chain	ID=PRO_0000284110;Note=IQ domain-containing protein E
IQCE	Q6IPM2	544	581	542	571	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQCE	Q6IPM2	415	449	387	477	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IQCE	Q6IPM2	86	131	101	101	Natural variant	ID=VAR_031697;Note=H->N;Dbxref=dbSNP:rs11976972
IQCE	Q6IPM2	544	581	546	546	Natural variant	ID=VAR_031698;Note=A->V;Dbxref=dbSNP:rs2293404
IQCE	Q6IPM2	544	581	579	579	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2BP1	Q9NZI8	134	227	1	577	Chain	ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1
IGF2BP1	Q9NZI8	509	547	1	577	Chain	ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1
IGF2BP1	Q9NZI8	134	227	81	156	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
IGF2BP1	Q9NZI8	134	227	195	260	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP1	Q9NZI8	509	547	487	553	Domain	Note=KH 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP1	Q9NZI8	134	227	187	570	Region	Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
IGF2BP1	Q9NZI8	509	547	187	570	Region	Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
IGF2BP1	Q9NZI8	134	227	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:20068231,PMID:23186163
IGF2BP1	Q9NZI8	509	547	528	528	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
IGF2BP1	Q9NZI8	134	227	135	273	Alternative sequence	ID=VSP_045366;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IGF2BP1	Q9NZI8	134	227	213	214	Mutagenesis	Note=50-fold decrease in RNA-binding affinity%2C decreased location in cytoplasmic RNP%2C increased nuclear location%3B when associated with 294-E-L-295 and 423-E-L-424. KE->EL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12921532;Dbxref=PMID:12921532
IGF2BP1	Q9NZI8	509	547	508	517	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP1	Q9NZI8	509	547	520	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP1	Q9NZI8	509	547	533	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP1	Q9NZI8	509	547	543	560	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IFFO2	Q5TF58	274	321	1	517	Chain	ID=PRO_0000326185;Note=Intermediate filament family orphan 2
IFFO2	Q5TF58	274	321	53	484	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
IFT27	Q9BW83	58	78	1	186	Chain	ID=PRO_0000082715;Note=Intraflagellar transport protein 27 homolog
IFT27	Q9BW83	58	78	64	68	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
IFT27	Q9BW83	58	78	68	68	Mutagenesis	Note=GTP-locked. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25443296;Dbxref=PMID:25443296
IGSF11	Q5DX21	141	193	23	431	Chain	ID=PRO_0000317370;Note=Immunoglobulin superfamily member 11
IGSF11	Q5DX21	141	193	23	241	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF11	Q5DX21	141	193	144	234	Domain	Note=Ig-like C2-type
IGSF11	Q5DX21	141	193	165	215	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
INPP1	P49441	88	155	1	399	Chain	ID=PRO_0000142510;Note=Inositol polyphosphate 1-phosphatase
INPP1	P49441	88	155	1	399	Chain	ID=PRO_0000142510;Note=Inositol polyphosphate 1-phosphatase
INPP1	P49441	88	155	155	158	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	155	158	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	153	153	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	153	153	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	153	153	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	153	153	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	155	155	Metal binding	Note=Magnesium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	155	155	Metal binding	Note=Magnesium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	119	119	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP1	P49441	88	155	119	119	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP5K	Q9BT40	87	126	1	448	Chain	ID=PRO_0000209727;Note=Inositol polyphosphate 5-phosphatase K
INPP5K	Q9BT40	87	126	16	318	Region	Note=Catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255
INPP5K	Q9BT40	87	126	93	93	Natural variant	ID=VAR_079000;Note=In MDCCAID%3B decreased phosphatidylinositol-4%2C5-bisphosphate 5-phosphatase activity. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28190459;Dbxref=dbSNP:rs1060505039,PMID:28190459
INPP5K	Q9BT40	87	126	120	120	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
INTS10	Q9NVR2	459	510	1	710	Chain	ID=PRO_0000235687;Note=Integrator complex subunit 10
INTS10	Q9NVR2	459	510	464	464	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:28112733
INTS2	Q9H0H0	1018	1054	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	704	759	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	669	704	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	529	574	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	506	529	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	402	443	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	186	224	1	1204	Chain	ID=PRO_0000236099;Note=Integrator complex subunit 2
INTS2	Q9H0H0	402	443	428	444	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IPO7	O95373	212	242	1	1038	Chain	ID=PRO_0000120750;Note=Importin-7
IPO7	O95373	445	475	1	1038	Chain	ID=PRO_0000120750;Note=Importin-7
IPO7	O95373	584	627	1	1038	Chain	ID=PRO_0000120750;Note=Importin-7
IPO7	O95373	649	691	1	1038	Chain	ID=PRO_0000120750;Note=Importin-7
IPO8	O15397	966	1005	1	1037	Chain	ID=PRO_0000120752;Note=Importin-8
IPO8	O15397	898	966	1	1037	Chain	ID=PRO_0000120752;Note=Importin-8
IPO8	O15397	303	348	1	1037	Chain	ID=PRO_0000120752;Note=Importin-8
IPO8	O15397	108	160	1	1037	Chain	ID=PRO_0000120752;Note=Importin-8
IPO8	O15397	898	966	923	928	Compositional bias	Note=Poly-Glu
IPO8	O15397	898	966	902	902	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692
IPO8	O15397	898	966	903	903	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692
IPO8	O15397	108	160	1	213	Alternative sequence	ID=VSP_042574;Note=In isoform 2. MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKHDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLPRIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQ->MESLTLKG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IRF3	Q14653	200	327	1	427	Chain	ID=PRO_0000154553;Note=Interferon regulatory factor 3
IRF3	Q14653	200	327	1	427	Chain	ID=PRO_0000154553;Note=Interferon regulatory factor 3
IRF3	Q14653	200	327	1	427	Chain	ID=PRO_0000154553;Note=Interferon regulatory factor 3
IRF3	Q14653	200	327	200	360	Region	Note=Involved in HERC5 binding
IRF3	Q14653	200	327	200	360	Region	Note=Involved in HERC5 binding
IRF3	Q14653	200	327	200	360	Region	Note=Involved in HERC5 binding
IRF3	Q14653	200	327	237	237	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	237	237	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	237	237	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	244	244	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	244	244	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	244	244	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	253	253	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	253	253	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	253	253	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23746807;Dbxref=PMID:23746807
IRF3	Q14653	200	327	267	289	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14555995,ECO:0000269|PubMed:14555996;Dbxref=PMID:14555995,PMID:14555996
IRF3	Q14653	200	327	267	289	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14555995,ECO:0000269|PubMed:14555996;Dbxref=PMID:14555995,PMID:14555996
IRF3	Q14653	200	327	267	289	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14555995,ECO:0000269|PubMed:14555996;Dbxref=PMID:14555995,PMID:14555996
IRF3	Q14653	200	327	105	427	Alternative sequence	ID=VSP_047691;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IRF3	Q14653	200	327	105	427	Alternative sequence	ID=VSP_047691;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IRF3	Q14653	200	327	105	427	Alternative sequence	ID=VSP_047691;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IRF3	Q14653	200	327	201	327	Alternative sequence	ID=VSP_043319;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IRF3	Q14653	200	327	201	327	Alternative sequence	ID=VSP_043319;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IRF3	Q14653	200	327	201	327	Alternative sequence	ID=VSP_043319;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IRF3	Q14653	200	327	285	285	Natural variant	ID=VAR_075805;Note=In IIAE7%3B loss of viral infection-induced phosphorylation at S-386%3B loss of viral infection-induced homodimerization%3B loss of viral infection-induced transcription factor activity%3B unable to activate interferon transcription in response to viral infection. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26216125;Dbxref=dbSNP:rs750526659,PMID:26216125
IRF3	Q14653	200	327	285	285	Natural variant	ID=VAR_075805;Note=In IIAE7%3B loss of viral infection-induced phosphorylation at S-386%3B loss of viral infection-induced homodimerization%3B loss of viral infection-induced transcription factor activity%3B unable to activate interferon transcription in response to viral infection. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26216125;Dbxref=dbSNP:rs750526659,PMID:26216125
IRF3	Q14653	200	327	285	285	Natural variant	ID=VAR_075805;Note=In IIAE7%3B loss of viral infection-induced phosphorylation at S-386%3B loss of viral infection-induced homodimerization%3B loss of viral infection-induced transcription factor activity%3B unable to activate interferon transcription in response to viral infection. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26216125;Dbxref=dbSNP:rs750526659,PMID:26216125
IRF3	Q14653	200	327	204	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	204	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	204	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	213	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	213	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	213	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	226	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	226	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	226	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	238	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	238	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	238	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	248	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A77
IRF3	Q14653	200	327	248	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A77
IRF3	Q14653	200	327	248	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A77
IRF3	Q14653	200	327	252	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEJ
IRF3	Q14653	200	327	252	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEJ
IRF3	Q14653	200	327	252	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEJ
IRF3	Q14653	200	327	255	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	255	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	255	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	267	270	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZOQ
IRF3	Q14653	200	327	267	270	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZOQ
IRF3	Q14653	200	327	267	270	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZOQ
IRF3	Q14653	200	327	272	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	272	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	272	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	287	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	287	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	287	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	304	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEO
IRF3	Q14653	200	327	304	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEO
IRF3	Q14653	200	327	304	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEO
IRF3	Q14653	200	327	308	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	308	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	308	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	313	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	313	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	313	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	317	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	317	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	317	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	322	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	322	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IRF3	Q14653	200	327	322	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JEL
IL2RA	P01589	218	242	22	272	Chain	ID=PRO_0000011024;Note=Interleukin-2 receptor subunit alpha
IL2RA	P01589	122	194	22	272	Chain	ID=PRO_0000011024;Note=Interleukin-2 receptor subunit alpha
IL2RA	P01589	218	242	22	240	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL2RA	P01589	122	194	22	240	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL2RA	P01589	218	242	241	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL2RA	P01589	122	194	123	186	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
IL2RA	P01589	218	242	218	218	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3134887;Dbxref=PMID:3134887
IL2RA	P01589	218	242	224	224	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3134887;Dbxref=PMID:3134887
IL2RA	P01589	218	242	229	229	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3134887;Dbxref=PMID:3134887
IL2RA	P01589	218	242	237	237	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3134887;Dbxref=PMID:3134887
IL2RA	P01589	122	194	24	168	Disulfide bond	.
IL2RA	P01589	122	194	67	125	Disulfide bond	.
IL2RA	P01589	122	194	152	184	Disulfide bond	.
IL2RA	P01589	122	194	166	166	Natural variant	ID=VAR_074642;Note=In IMD41%3B the receptor does not localize to the plasma membrane. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23416241;Dbxref=dbSNP:rs796051887,PMID:23416241
IL2RA	P01589	122	194	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IU3
IL2RA	P01589	122	194	143	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NFP
IL2RA	P01589	122	194	147	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5I
IL2RA	P01589	122	194	157	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5I
IL2RA	P01589	122	194	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5I
IL2RA	P01589	122	194	172	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z92
IL2RA	P01589	122	194	175	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5I
IL2RA	P01589	122	194	182	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5I
SERPINB1	P30740	189	245	1	379	Chain	ID=PRO_0000094101;Note=Leukocyte elastase inhibitor
SERPINB1	P30740	56	102	1	379	Chain	ID=PRO_0000094101;Note=Leukocyte elastase inhibitor
SERPINB1	P30740	56	102	1	151	Alternative sequence	ID=VSP_056511;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERPINB1	P30740	56	102	82	82	Natural variant	ID=VAR_051945;Note=A->V;Dbxref=dbSNP:rs34825616
SERPINB1	P30740	56	102	48	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	56	102	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	56	102	66	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	56	102	83	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	56	102	102	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	189	245	191	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	189	245	210	213	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	189	245	214	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	189	245	224	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	189	245	238	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
SERPINB1	P30740	189	245	244	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GA7
IL1RL2	Q9HB29	216	241	20	575	Chain	ID=PRO_0000015445;Note=Interleukin-1 receptor-like 2
IL1RL2	Q9HB29	378	432	20	575	Chain	ID=PRO_0000015445;Note=Interleukin-1 receptor-like 2
IL1RL2	Q9HB29	216	241	20	335	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL1RL2	Q9HB29	378	432	357	575	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL1RL2	Q9HB29	216	241	222	318	Domain	Note=Ig-like C2-type 3
IL1RL2	Q9HB29	378	432	381	539	Domain	Note=TIR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00204
IL1RL2	Q9HB29	216	241	234	234	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL1RL2	Q9HB29	216	241	217	218	Alternative sequence	ID=VSP_056294;Note=In isoform 2. TE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IL1RL2	Q9HB29	216	241	237	237	Natural variant	ID=VAR_053378;Note=I->T;Dbxref=dbSNP:rs13405631
MIF4GD	A9UHW6	64	116	1	222	Chain	ID=PRO_0000337089;Note=MIF4G domain-containing protein
MIF4GD	A9UHW6	64	116	3	205	Domain	Note=MIF4G
KPNA3	O00505	301	344	2	521	Chain	ID=PRO_0000120724;Note=Importin subunit alpha-4
KPNA3	O00505	257	301	2	521	Chain	ID=PRO_0000120724;Note=Importin subunit alpha-4
KPNA3	O00505	68	78	2	521	Chain	ID=PRO_0000120724;Note=Importin subunit alpha-4
KPNA3	O00505	68	78	66	106	Repeat	Note=ARM 1%3B truncated
KPNA3	O00505	257	301	234	278	Repeat	Note=ARM 5
KPNA3	O00505	301	344	279	318	Repeat	Note=ARM 6
KPNA3	O00505	257	301	279	318	Repeat	Note=ARM 6
KPNA3	O00505	301	344	319	360	Repeat	Note=ARM 7
KPNA3	O00505	301	344	306	394	Region	Note=NLS binding site (minor);Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA3	O00505	257	301	291	291	Natural variant	ID=VAR_014454;Note=P->S;Dbxref=dbSNP:rs1043015
KPNA3	O00505	257	301	259	259	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA3	O00505	301	344	332	332	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA1	P52294	332	374	1	538	Chain	ID=PRO_0000120719;Note=Importin subunit alpha-5
KPNA1	P52294	144	188	1	538	Chain	ID=PRO_0000120719;Note=Importin subunit alpha-5
KPNA1	P52294	332	374	2	538	Chain	ID=PRO_0000424491;Note=Importin subunit alpha-5%2C N-terminally processed
KPNA1	P52294	144	188	2	538	Chain	ID=PRO_0000424491;Note=Importin subunit alpha-5%2C N-terminally processed
KPNA1	P52294	144	188	118	161	Repeat	Note=ARM 2
KPNA1	P52294	144	188	162	206	Repeat	Note=ARM 3
KPNA1	P52294	332	374	331	372	Repeat	Note=ARM 7
KPNA1	P52294	332	374	373	412	Repeat	Note=ARM 8
KPNA1	P52294	144	188	149	241	Region	Note=NLS binding site (major);Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA1	P52294	332	374	245	437	Region	Note=Binding to RAG1
KPNA1	P52294	332	374	318	406	Region	Note=NLS binding site (minor);Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA1	P52294	144	188	169	169	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNA1	P52294	144	188	141	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	144	188	159	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	144	188	170	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	144	188	183	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	332	374	328	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	332	374	336	338	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	332	374	339	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	332	374	352	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
KPNA1	P52294	332	374	370	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDQ
IMPACT	Q9P2X3	73	93	1	320	Chain	ID=PRO_0000330850;Note=Protein IMPACT
IMPACT	Q9P2X3	253	298	1	320	Chain	ID=PRO_0000330850;Note=Protein IMPACT
IMPACT	Q9P2X3	73	93	14	116	Domain	Note=RWD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00179
IMPACT	Q9P2X3	253	298	297	297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5GFD9
IMPACT	Q9P2X3	73	93	1	118	Alternative sequence	ID=VSP_033136;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IMPACT	Q9P2X3	73	93	74	74	Natural variant	ID=VAR_077844;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27607563;Dbxref=dbSNP:rs544203385,PMID:27607563
INO80	Q9ULG1	969	1016	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	594	614	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	562	594	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	465	535	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	309	377	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	291	309	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	969	1016	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	594	614	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	562	594	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	465	535	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	309	377	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	291	309	1	1556	Chain	ID=PRO_0000248829;Note=Chromatin-remodeling ATPase INO80
INO80	Q9ULG1	309	377	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00746
INO80	Q9ULG1	291	309	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00746
INO80	Q9ULG1	309	377	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00746
INO80	Q9ULG1	291	309	280	405	Domain	Note=DBINO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00746
INO80	Q9ULG1	594	614	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
INO80	Q9ULG1	562	594	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
INO80	Q9ULG1	465	535	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
INO80	Q9ULG1	594	614	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
INO80	Q9ULG1	562	594	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
INO80	Q9ULG1	465	535	530	701	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
INO80	Q9ULG1	465	535	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	309	377	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	291	309	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	465	535	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	309	377	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	291	309	212	526	Region	Note=Assembles INO80 complex module consisting of conserved components ACTR8%2C ACTL6A and YY1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	969	1016	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	594	614	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	562	594	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	465	535	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	969	1016	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	594	614	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	562	594	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
INO80	Q9ULG1	465	535	521	1556	Region	Note=Assembles INO80 complex module consisting of conserved components INO80B%2C INO80C%2C ACTR5%2C RVBL1%2C RVBL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21303910;Dbxref=PMID:21303910
ILF2	Q12905	131	153	1	390	Chain	ID=PRO_0000126063;Note=Interleukin enhancer-binding factor 2
ILF2	Q12905	71	97	1	390	Chain	ID=PRO_0000126063;Note=Interleukin enhancer-binding factor 2
ILF2	Q12905	36	71	1	390	Chain	ID=PRO_0000126063;Note=Interleukin enhancer-binding factor 2
ILF2	Q12905	131	153	24	371	Domain	Note=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
ILF2	Q12905	71	97	24	371	Domain	Note=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
ILF2	Q12905	36	71	24	371	Domain	Note=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
ILF2	Q12905	36	71	52	52	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ILF2	Q12905	36	71	68	68	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ILKAP	Q9H0C8	279	318	1	392	Chain	ID=PRO_0000272271;Note=Integrin-linked kinase-associated serine/threonine phosphatase 2C
ILKAP	Q9H0C8	59	99	1	392	Chain	ID=PRO_0000272271;Note=Integrin-linked kinase-associated serine/threonine phosphatase 2C
ILKAP	Q9H0C8	279	318	108	390	Domain	Note=PPM-type phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01082
ILKAP	Q9H0C8	59	99	66	66	Natural variant	ID=VAR_061542;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs34371548,PMID:14702039
CHCHD4	Q8N4Q1	7	40	1	142	Chain	ID=PRO_0000129165;Note=Mitochondrial intermembrane space import and assembly protein 40
INF2	Q27J81	328	578	2	1249	Chain	ID=PRO_0000310963;Note=Inverted formin-2
INF2	Q27J81	770	806	2	1249	Chain	ID=PRO_0000310963;Note=Inverted formin-2
INF2	Q27J81	328	578	2	330	Domain	Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579
INF2	Q27J81	328	578	554	946	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
INF2	Q27J81	770	806	554	946	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
INF2	Q27J81	328	578	389	393	Compositional bias	Note=Poly-Ala
INF2	Q27J81	328	578	421	520	Compositional bias	Note=Pro-rich
INF2	Q27J81	328	578	351	351	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
INF2	Q27J81	328	578	235	1249	Alternative sequence	ID=VSP_029360;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
INF2	Q27J81	770	806	235	1249	Alternative sequence	ID=VSP_029360;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
INF2	Q27J81	328	578	547	547	Natural variant	ID=VAR_072237;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21866090;Dbxref=dbSNP:rs376451593,PMID:21866090
INPP4A	Q96PE3	35	50	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	316	351	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	454	527	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	612	623	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	35	50	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	316	351	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	454	527	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	612	623	1	977	Chain	ID=PRO_0000190232;Note=Type I inositol 3%2C4-bisphosphate 4-phosphatase
INPP4A	Q96PE3	35	50	31	137	Domain	Note=C2
INPP4A	Q96PE3	35	50	31	137	Domain	Note=C2
INPP4A	Q96PE3	454	527	487	487	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
INPP4A	Q96PE3	454	527	487	487	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
INPP4A	Q96PE3	612	623	574	613	Alternative sequence	ID=VSP_015241;Note=In isoform 2 and isoform 4. GNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTH->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7608176,ECO:0000303|PubMed:9295334;Dbxref=PMID:7608176,PMID:9295334
INPP4A	Q96PE3	612	623	574	613	Alternative sequence	ID=VSP_015241;Note=In isoform 2 and isoform 4. GNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTH->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7608176,ECO:0000303|PubMed:9295334;Dbxref=PMID:7608176,PMID:9295334
INTS9	Q9NV88	203	248	1	658	Chain	ID=PRO_0000259557;Note=Integrator complex subunit 9
INTS9	Q9NV88	134	162	1	658	Chain	ID=PRO_0000259557;Note=Integrator complex subunit 9
INTS9	Q9NV88	66	87	1	658	Chain	ID=PRO_0000259557;Note=Integrator complex subunit 9
INTS9	Q9NV88	66	87	67	87	Alternative sequence	ID=VSP_043011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IDH3A	P50213	9	30	1	27	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25944712;Dbxref=PMID:25944712
IDH3A	P50213	9	30	28	366	Chain	ID=PRO_0000014436;Note=Isocitrate dehydrogenase [NAD] subunit alpha%2C mitochondrial
IDH3A	P50213	30	58	28	366	Chain	ID=PRO_0000014436;Note=Isocitrate dehydrogenase [NAD] subunit alpha%2C mitochondrial
IDH3A	P50213	288	339	28	366	Chain	ID=PRO_0000014436;Note=Isocitrate dehydrogenase [NAD] subunit alpha%2C mitochondrial
IDH3A	P50213	9	30	1	78	Alternative sequence	ID=VSP_014516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
IDH3A	P50213	30	58	1	78	Alternative sequence	ID=VSP_014516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
IDH3A	P50213	30	58	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3A	P50213	30	58	43	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3A	P50213	288	339	294	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3A	P50213	288	339	297	300	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3A	P50213	288	339	305	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3A	P50213	288	339	321	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3A	P50213	288	339	338	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRF
ICOSLG	O75144	18	135	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
ICOSLG	O75144	18	135	19	302	Chain	ID=PRO_0000014803;Note=ICOS ligand
ICOSLG	O75144	18	135	19	256	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICOSLG	O75144	18	135	19	129	Domain	Note=Ig-like V-type
ICOSLG	O75144	18	135	70	70	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
ICOSLG	O75144	18	135	102	102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
ICOSLG	O75144	18	135	37	113	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
ICOSLG	O75144	18	135	18	134	Alternative sequence	ID=VSP_054718;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ICOSLG	O75144	18	135	128	128	Natural variant	ID=VAR_049880;Note=V->I;Dbxref=dbSNP:rs11558819
IDUA	P35475	128	164	28	653	Chain	ID=PRO_0000012200;Note=Alpha-L-iduronidase
IDUA	P35475	164	196	28	653	Chain	ID=PRO_0000012200;Note=Alpha-L-iduronidase
IDUA	P35475	508	550	28	653	Chain	ID=PRO_0000012200;Note=Alpha-L-iduronidase
IDUA	P35475	164	196	182	182	Active site	Note=Proton donor;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10068,ECO:0000269|PubMed:24036510;Dbxref=PMID:24036510
IDUA	P35475	164	196	181	181	Binding site	Note=Substrate
IDUA	P35475	164	196	190	190	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IDUA	P35475	508	550	541	577	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23959878,ECO:0000269|PubMed:24036510;Dbxref=PMID:23959878,PMID:24036510
IDUA	P35475	128	164	133	133	Natural variant	ID=VAR_020977;Note=In MPS1H. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559846;Dbxref=dbSNP:rs558683362,PMID:12559846
IDUA	P35475	164	196	178	178	Natural variant	ID=VAR_066218;Note=In MPS1H/S. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21394825;Dbxref=PMID:21394825
IDUA	P35475	164	196	182	182	Natural variant	ID=VAR_020978;Note=In MPS1H. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559846;Dbxref=dbSNP:rs754154200,PMID:12559846
IDUA	P35475	164	196	188	188	Natural variant	ID=VAR_066219;Note=In MPS1H/S%3B associated with R-423. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21394825;Dbxref=PMID:21394825
IDUA	P35475	508	550	533	533	Natural variant	ID=VAR_003378;Note=In MPS1H and MPS1H/S%3B in 3%25 of the MPS1H patients%3B reduces catalytic activity and protein stability. P->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12559846,ECO:0000269|PubMed:1301941,ECO:0000269|PubMed:15300847,ECO:0000269|PubMed:21394825,ECO:0000269|PubMed:24036510;Dbxref=dbSNP:rs121965021,PMID:12559846,PMID:1301941,PMID:15300847,PMID:21394825,PMID:24036510
IDUA	P35475	508	550	535	535	Natural variant	ID=VAR_066230;Note=In MPS1H/S. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21394825;Dbxref=PMID:21394825
IDUA	P35475	128	164	127	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	128	164	136	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	128	164	142	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KGJ
IDUA	P35475	128	164	146	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	164	196	146	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	164	196	169	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	164	196	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	164	196	183	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	164	196	195	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	508	550	511	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3W81
IDUA	P35475	508	550	520	522	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	508	550	524	526	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
IDUA	P35475	508	550	529	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MJ2
EIF1AX	P47813	68	85	1	144	Chain	ID=PRO_0000145101;Note=Eukaryotic translation initiation factor 1A%2C X-chromosomal
EIF1AX	P47813	68	85	22	96	Domain	Note=S1-like
EIF1AX	P47813	68	85	76	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D7Q
EIF1AX	P47813	68	85	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D7Q
EIF2S2	P20042	228	246	2	333	Chain	ID=PRO_0000137406;Note=Eukaryotic translation initiation factor 2 subunit 2
IL7	P13232	120	138	26	177	Chain	ID=PRO_0000015623;Note=Interleukin-7
IL7	P13232	76	120	26	177	Chain	ID=PRO_0000015623;Note=Interleukin-7
IL7	P13232	76	120	95	95	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL7	P13232	76	120	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL7	P13232	120	138	27	166	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080
IL7	P13232	76	120	27	166	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080
IL7	P13232	120	138	59	154	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080
IL7	P13232	76	120	59	154	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080
IL7	P13232	76	120	72	117	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080
IL7	P13232	120	138	77	138	Alternative sequence	ID=VSP_047580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL7	P13232	76	120	77	138	Alternative sequence	ID=VSP_047580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL7	P13232	120	138	77	120	Alternative sequence	ID=VSP_042926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL7	P13232	76	120	77	120	Alternative sequence	ID=VSP_042926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL7	P13232	76	120	77	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DI2
IL7	P13232	76	120	99	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DI2
IL24	Q13007	101	154	52	206	Chain	ID=PRO_0000015386;Note=Interleukin-24
IL24	Q13007	101	154	126	126	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL24	Q13007	101	154	122	122	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23078624;Dbxref=PMID:23078624
IL24	Q13007	101	154	15	206	Alternative sequence	ID=VSP_043915;Note=In isoform 4. RPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL->SKLRITSRVPGCCSRRFCRTSRKKMRCFPSETVHTGGFCYSGEHSNSWT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15304100;Dbxref=PMID:15304100
IL24	Q13007	101	154	101	153	Alternative sequence	ID=VSP_042674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16313301;Dbxref=PMID:16313301
IL24	Q13007	101	154	124	124	Natural variant	ID=VAR_011974;Note=Y->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11704829,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1150258,PMID:11704829
IL24	Q13007	101	154	125	125	Natural variant	ID=VAR_013097;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3093431
IL24	Q13007	101	154	131	131	Natural variant	ID=VAR_013098;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3093446
TTC26	A0AVF1	47	78	1	554	Chain	ID=PRO_0000289082;Note=Intraflagellar transport protein 56
TTC26	A0AVF1	239	264	1	554	Chain	ID=PRO_0000289082;Note=Intraflagellar transport protein 56
TTC26	A0AVF1	317	335	1	554	Chain	ID=PRO_0000289082;Note=Intraflagellar transport protein 56
TTC26	A0AVF1	47	78	57	90	Repeat	Note=TPR 1
TTC26	A0AVF1	47	78	47	77	Alternative sequence	ID=VSP_044791;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PYHIN1	Q6K0P9	137	193	1	492	Chain	ID=PRO_0000334524;Note=Pyrin and HIN domain-containing protein 1
IL18	Q14116	30	75	1	36	Propeptide	ID=PRO_0000015343;Ontology_term=ECO:0000250;evidence=ECO:0000250
IL18	Q14116	30	75	1	36	Propeptide	ID=PRO_0000015343;Ontology_term=ECO:0000250;evidence=ECO:0000250
IL18	Q14116	30	75	37	193	Chain	ID=PRO_0000015344;Note=Interleukin-18
IL18	Q14116	30	75	37	193	Chain	ID=PRO_0000015344;Note=Interleukin-18
IL18	Q14116	30	75	27	30	Alternative sequence	ID=VSP_044934;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15326478;Dbxref=PMID:15326478
IL18	Q14116	30	75	27	30	Alternative sequence	ID=VSP_044934;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15326478;Dbxref=PMID:15326478
IL18	Q14116	30	75	40	40	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	40	40	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	41	41	Mutagenesis	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	41	41	Mutagenesis	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	44	44	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	44	44	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	49	49	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	49	49	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	53	53	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	53	53	Mutagenesis	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	69	69	Mutagenesis	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	69	69	Mutagenesis	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	71	71	Mutagenesis	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	71	71	Mutagenesis	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293
IL18	Q14116	30	75	66	66	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL18	Q14116	30	75	66	66	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL18	Q14116	30	75	42	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	42	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	55	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	55	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	64	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	64	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	71	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18	Q14116	30	75	71	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VXT
IL18R1	Q13478	208	229	19	541	Chain	ID=PRO_0000015448;Note=Interleukin-18 receptor 1
IL18R1	Q13478	316	370	19	541	Chain	ID=PRO_0000015448;Note=Interleukin-18 receptor 1
IL18R1	Q13478	370	423	19	541	Chain	ID=PRO_0000015448;Note=Interleukin-18 receptor 1
IL18R1	Q13478	208	229	19	541	Chain	ID=PRO_0000015448;Note=Interleukin-18 receptor 1
IL18R1	Q13478	316	370	19	541	Chain	ID=PRO_0000015448;Note=Interleukin-18 receptor 1
IL18R1	Q13478	370	423	19	541	Chain	ID=PRO_0000015448;Note=Interleukin-18 receptor 1
IL18R1	Q13478	208	229	22	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	316	370	22	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	208	229	22	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	316	370	22	329	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	316	370	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	316	370	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	316	370	351	541	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	370	423	351	541	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	316	370	351	541	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	370	423	351	541	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL18R1	Q13478	208	229	133	212	Domain	Note=Ig-like C2-type 2
IL18R1	Q13478	208	229	133	212	Domain	Note=Ig-like C2-type 2
IL18R1	Q13478	208	229	220	312	Domain	Note=Ig-like C2-type 3
IL18R1	Q13478	208	229	220	312	Domain	Note=Ig-like C2-type 3
IL18R1	Q13478	370	423	373	523	Domain	Note=TIR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00204
IL18R1	Q13478	370	423	373	523	Domain	Note=TIR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00204
IL18R1	Q13478	208	229	210	210	Natural variant	ID=VAR_053379;Note=R->H;Dbxref=dbSNP:rs11465635
IL18R1	Q13478	208	229	210	210	Natural variant	ID=VAR_053379;Note=R->H;Dbxref=dbSNP:rs11465635
IL18R1	Q13478	316	370	317	317	Natural variant	ID=VAR_014955;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8626725;Dbxref=PMID:8626725
IL18R1	Q13478	316	370	317	317	Natural variant	ID=VAR_014955;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8626725;Dbxref=PMID:8626725
IL18R1	Q13478	370	423	423	423	Natural variant	ID=VAR_053382;Note=G->R;Dbxref=dbSNP:rs12619169
IL18R1	Q13478	370	423	423	423	Natural variant	ID=VAR_053382;Note=G->R;Dbxref=dbSNP:rs12619169
IL18R1	Q13478	208	229	216	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WO4
IL18R1	Q13478	208	229	216	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WO4
IL18R1	Q13478	208	229	221	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R6U
IL18R1	Q13478	208	229	221	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R6U
IL37	Q9NZH6	48	88	46	218	Chain	ID=PRO_0000015336;Note=Interleukin-37
IL37	Q9NZH6	48	88	1	49	Alternative sequence	ID=VSP_002653;Note=In isoform A. MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHTS->MSGCDRRETETKGKNSFKKRLRG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10625660;Dbxref=PMID:10625660
IL37	Q9NZH6	48	88	28	88	Alternative sequence	ID=VSP_002655;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11991723;Dbxref=PMID:11991723
IL37	Q9NZH6	48	88	28	49	Alternative sequence	ID=VSP_002654;Note=In isoform D. DPAGSPLEPGPSLPTMNFVHTS->G;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11991723,ECO:0000303|PubMed:19054851;Dbxref=PMID:11991723,PMID:19054851
IL37	Q9NZH6	48	88	49	89	Alternative sequence	ID=VSP_002656;Note=In isoform C. SPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11145836;Dbxref=PMID:11145836
IL37	Q9NZH6	48	88	50	50	Natural variant	ID=VAR_049574;Note=P->R;Dbxref=dbSNP:rs2708943
IL37	Q9NZH6	48	88	54	54	Natural variant	ID=VAR_049575;Note=N->S;Dbxref=dbSNP:rs2723183
IL37	Q9NZH6	48	88	58	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HN1
IL37	Q9NZH6	48	88	76	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HN1
KPNA4	O00629	379	403	2	521	Chain	ID=PRO_0000120726;Note=Importin subunit alpha-3
KPNA4	O00629	301	344	2	521	Chain	ID=PRO_0000120726;Note=Importin subunit alpha-3
KPNA4	O00629	257	301	2	521	Chain	ID=PRO_0000120726;Note=Importin subunit alpha-3
KPNA4	O00629	242	257	2	521	Chain	ID=PRO_0000120726;Note=Importin subunit alpha-3
KPNA4	O00629	257	301	234	278	Repeat	Note=ARM 5
KPNA4	O00629	242	257	234	278	Repeat	Note=ARM 5
KPNA4	O00629	301	344	279	318	Repeat	Note=ARM 6
KPNA4	O00629	257	301	279	318	Repeat	Note=ARM 6
KPNA4	O00629	301	344	319	360	Repeat	Note=ARM 7
KPNA4	O00629	379	403	361	400	Repeat	Note=ARM 8
KPNA4	O00629	379	403	401	443	Repeat	Note=ARM 9
KPNA4	O00629	379	403	306	394	Region	Note=NLS binding site (minor);Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA4	O00629	301	344	306	394	Region	Note=NLS binding site (minor);Ontology_term=ECO:0000250;evidence=ECO:0000250
KPNA4	O00629	242	257	237	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	257	301	256	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	242	257	256	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	257	301	274	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	257	301	286	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	257	301	290	294	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	301	344	298	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	257	301	298	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	301	344	316	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	301	344	324	326	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	301	344	327	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	301	344	332	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	301	344	340	353	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	379	403	370	379	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	379	403	382	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNA4	O00629	379	403	401	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UAE
KPNB1	Q14974	94	161	1	876	Chain	ID=PRO_0000120745;Note=Importin subunit beta-1
KPNB1	Q14974	232	262	1	876	Chain	ID=PRO_0000120745;Note=Importin subunit beta-1
KPNB1	Q14974	262	299	1	876	Chain	ID=PRO_0000120745;Note=Importin subunit beta-1
KPNB1	Q14974	408	472	1	876	Chain	ID=PRO_0000120745;Note=Importin subunit beta-1
KPNB1	Q14974	565	589	1	876	Chain	ID=PRO_0000120745;Note=Importin subunit beta-1
KPNB1	Q14974	94	161	21	101	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
KPNB1	Q14974	94	161	85	123	Repeat	Note=HEAT 3;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10353244,ECO:0000269|PubMed:10367892;Dbxref=PMID:10353244,PMID:10367892
KPNB1	Q14974	94	161	129	160	Repeat	Note=HEAT 4;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10353244,ECO:0000269|PubMed:10367892;Dbxref=PMID:10353244,PMID:10367892
KPNB1	Q14974	232	262	212	247	Repeat	Note=HEAT 6;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10353244,ECO:0000269|PubMed:10367892;Dbxref=PMID:10353244,PMID:10367892
KPNB1	Q14974	232	262	253	302	Repeat	Note=HEAT 7;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10353244,ECO:0000269|PubMed:10367892;Dbxref=PMID:10353244,PMID:10367892
KPNB1	Q14974	262	299	253	302	Repeat	Note=HEAT 7;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10353244,ECO:0000269|PubMed:10367892;Dbxref=PMID:10353244,PMID:10367892
KPNB1	Q14974	408	472	402	438	Repeat	Note=HEAT 10;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10353244,ECO:0000269|PubMed:10367892;Dbxref=PMID:10353244,PMID:10367892
KPNB1	Q14974	408	472	449	485	Repeat	Note=HEAT 11;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353244;Dbxref=PMID:10353244
KPNB1	Q14974	565	589	544	592	Repeat	Note=HEAT 13;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353244;Dbxref=PMID:10353244
KPNB1	Q14974	408	472	334	419	Region	Note=Ran-GTP binding
KPNB1	Q14974	94	161	1	145	Alternative sequence	ID=VSP_054612;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KPNB1	Q14974	94	161	97	97	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
KPNB1	Q14974	94	161	85	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	94	161	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QGR
KPNB1	Q14974	94	161	104	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	94	161	109	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	94	161	121	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	94	161	129	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	94	161	144	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	232	262	231	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	232	262	249	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	232	262	253	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	232	262	260	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	262	299	260	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	262	299	273	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	404	408	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	409	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	416	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	422	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	439	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	446	448	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	449	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IBR
KPNB1	Q14974	408	472	464	483	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QGR
KPNB1	Q14974	565	589	563	566	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QGR
KPNB1	Q14974	565	589	573	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QGR
IMPA1	P29218	66	100	1	277	Chain	ID=PRO_0000142513;Note=Inositol monophosphatase 1
IMPA1	P29218	66	100	92	95	Region	Note=Substrate binding;Ontology_term=ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:8068620,ECO:0000303|PubMed:8068621;Dbxref=PMID:8068620,PMID:8068621
IMPA1	P29218	66	100	70	70	Metal binding	Note=Magnesium 1%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000303,ECO:0000303;evidence=ECO:0000269|PubMed:23027737,ECO:0000269|PubMed:8068621,ECO:0000303|PubMed:1332026,ECO:0000303|PubMed:8068620;Dbxref=PMID:23027737,PMID:8068621,PMID:1332026,PMID:8068620
IMPA1	P29218	66	100	90	90	Metal binding	Note=Magnesium 1%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000303,ECO:0000303;evidence=ECO:0000269|PubMed:23027737,ECO:0000269|PubMed:8068621,ECO:0000303|PubMed:1332026,ECO:0000303|PubMed:8068620;Dbxref=PMID:23027737,PMID:8068621,PMID:1332026,PMID:8068620
IMPA1	P29218	66	100	90	90	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23027737,ECO:0000269|PubMed:8068621;Dbxref=PMID:23027737,PMID:8068621
IMPA1	P29218	66	100	92	92	Metal binding	Note=Magnesium 1%3B via carbonyl oxygen%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000303,ECO:0000303;evidence=ECO:0000269|PubMed:23027737,ECO:0000269|PubMed:8068621,ECO:0000303|PubMed:1332026,ECO:0000303|PubMed:8068620;Dbxref=PMID:23027737,PMID:8068621,PMID:1332026,PMID:8068620
IMPA1	P29218	66	100	93	93	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23027737,ECO:0000269|PubMed:8068621;Dbxref=PMID:23027737,PMID:8068621
IMPA1	P29218	66	100	70	70	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:8068620,ECO:0000303|PubMed:8068621;Dbxref=PMID:8068620,PMID:8068621
IMPA1	P29218	66	100	93	93	Mutagenesis	Note=Loss of activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17068342;Dbxref=PMID:17068342
IMPA1	P29218	66	100	66	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AS4
IMPA1	P29218	66	100	70	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AS4
IMPA1	P29218	66	100	86	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AS4
IMPA1	P29218	66	100	95	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AS4
ICAM5	Q9UMF0	224	320	32	924	Chain	ID=PRO_0000014799;Note=Intercellular adhesion molecule 5
ICAM5	Q9UMF0	405	488	32	924	Chain	ID=PRO_0000014799;Note=Intercellular adhesion molecule 5
ICAM5	Q9UMF0	224	320	32	835	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM5	Q9UMF0	405	488	32	835	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM5	Q9UMF0	224	320	135	235	Domain	Note=Ig-like C2-type 2
ICAM5	Q9UMF0	224	320	242	329	Domain	Note=Ig-like C2-type 3
ICAM5	Q9UMF0	405	488	408	486	Domain	Note=Ig-like C2-type 5
ICAM5	Q9UMF0	224	320	303	303	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM5	Q9UMF0	224	320	316	316	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ICAM5	Q9UMF0	224	320	249	302	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
ICAM5	Q9UMF0	405	488	415	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
ICAM5	Q9UMF0	224	320	301	301	Natural variant	ID=VAR_056046;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8995416;Dbxref=dbSNP:rs1056538,PMID:8995416
ICAM5	Q9UMF0	405	488	488	488	Natural variant	ID=VAR_035517;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ICAM5	Q9UMF0	224	320	223	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	232	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	237	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	245	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	253	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	257	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	261	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	281	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	295	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	224	320	309	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
ICAM5	Q9UMF0	405	488	392	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9
IDH3G	P51553	27	41	1	39	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
IDH3G	P51553	259	308	40	393	Chain	ID=PRO_0000014449;Note=Isocitrate dehydrogenase [NAD] subunit gamma%2C mitochondrial
IDH3G	P51553	27	41	40	393	Chain	ID=PRO_0000014449;Note=Isocitrate dehydrogenase [NAD] subunit gamma%2C mitochondrial
IDH3G	P51553	259	308	276	276	Mutagenesis	Note=Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate and ADP. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28098230;Dbxref=PMID:28098230
IDH3G	P51553	259	308	267	267	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
IDH3G	P51553	259	308	253	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3G	P51553	259	308	264	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3G	P51553	259	308	268	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3G	P51553	259	308	274	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3G	P51553	259	308	291	293	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3G	P51553	259	308	295	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
IDH3G	P51553	259	308	304	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GRI
MTIF2	P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	178	348	Domain	Note=tr-type G
MTIF2	P46199	221	280	178	348	Domain	Note=tr-type G
MTIF2	P46199	221	280	178	348	Domain	Note=tr-type G
MTIF2	P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12932832,ECO:0000269|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
MTIF2	P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12932832,ECO:0000269|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
MTIF2	P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12932832,ECO:0000269|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
EIF2S3	P41091	159	212	2	472	Chain	ID=PRO_0000137438;Note=Eukaryotic translation initiation factor 2 subunit 3
EIF2S3	P41091	212	257	2	472	Chain	ID=PRO_0000137438;Note=Eukaryotic translation initiation factor 2 subunit 3
EIF2S3	P41091	159	212	39	248	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	212	257	39	248	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	159	212	190	193	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF2S3	P41091	159	212	190	193	Region	Note=G4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	212	257	225	227	Region	Note=G5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	212	257	222	222	Natural variant	ID=VAR_077139;Note=In MEHMO%3B decreased interaction with the other eIF2 complex subunits EIF2S1 and EIF2S2. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23063529;Dbxref=dbSNP:rs886040855,PMID:23063529
IFT43	Q96FT9	18	49	1	208	Chain	ID=PRO_0000254041;Note=Intraflagellar transport protein 43 homolog
IFT43	Q96FT9	18	49	34	34	Natural variant	ID=VAR_080629;Note=In RP81%3B results in cilia shortening. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28973684;Dbxref=dbSNP:rs140366557,PMID:28973684
IGSF1	Q8N6C5	1061	1157	29	1336	Chain	ID=PRO_0000318512;Note=Immunoglobulin superfamily member 1
IGSF1	Q8N6C5	965	1061	29	1336	Chain	ID=PRO_0000318512;Note=Immunoglobulin superfamily member 1
IGSF1	Q8N6C5	773	869	29	1336	Chain	ID=PRO_0000318512;Note=Immunoglobulin superfamily member 1
IGSF1	Q8N6C5	572	583	29	1336	Chain	ID=PRO_0000318512;Note=Immunoglobulin superfamily member 1
IGSF1	Q8N6C5	572	583	560	580	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	1061	1157	581	1336	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	965	1061	581	1336	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	773	869	581	1336	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	572	583	581	1336	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	773	869	777	869	Domain	Note=Ig-like C2-type 8
IGSF1	Q8N6C5	965	1061	965	1060	Domain	Note=Ig-like C2-type 10
IGSF1	Q8N6C5	1061	1157	1065	1150	Domain	Note=Ig-like C2-type 11
IGSF1	Q8N6C5	773	869	798	798	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	773	869	846	846	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	965	1061	986	986	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	965	1061	1027	1027	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	1061	1157	1082	1082	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	1061	1157	1147	1147	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF1	Q8N6C5	773	869	799	849	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF1	Q8N6C5	1061	1157	1087	1134	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF1	Q8N6C5	1061	1157	243	1336	Alternative sequence	ID=VSP_031197;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11854097;Dbxref=PMID:11854097
IGSF1	Q8N6C5	965	1061	243	1336	Alternative sequence	ID=VSP_031197;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11854097;Dbxref=PMID:11854097
IGSF1	Q8N6C5	773	869	243	1336	Alternative sequence	ID=VSP_031197;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11854097;Dbxref=PMID:11854097
IGSF1	Q8N6C5	572	583	243	1336	Alternative sequence	ID=VSP_031197;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11854097;Dbxref=PMID:11854097
IGSF1	Q8N6C5	572	583	572	572	Alternative sequence	ID=VSP_044554;Note=In isoform 4. C->CAISFA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
IGSF1	Q8N6C5	773	869	774	774	Natural variant	ID=VAR_076256;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23092983;Dbxref=PMID:23092983
IGSF1	Q8N6C5	773	869	858	858	Natural variant	ID=VAR_069270;Note=In CHTE%3B impairs IGSF1 trafficking to the plasma membrane. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23143598;Dbxref=dbSNP:rs397514622,PMID:23143598
IFRD1	O00458	189	206	1	451	Chain	ID=PRO_0000153285;Note=Interferon-related developmental regulator 1
IFRD1	O00458	189	206	1	451	Chain	ID=PRO_0000153285;Note=Interferon-related developmental regulator 1
IFT57	Q9NWB7	327	348	1	429	Chain	ID=PRO_0000328884;Note=Intraflagellar transport protein 57 homolog
IFT57	Q9NWB7	283	327	1	429	Chain	ID=PRO_0000328884;Note=Intraflagellar transport protein 57 homolog
IFT57	Q9NWB7	218	259	1	429	Chain	ID=PRO_0000328884;Note=Intraflagellar transport protein 57 homolog
IFT57	Q9NWB7	195	218	1	429	Chain	ID=PRO_0000328884;Note=Intraflagellar transport protein 57 homolog
IFT57	Q9NWB7	327	348	335	426	Region	Note=pDED
IFT57	Q9NWB7	327	348	304	369	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT57	Q9NWB7	283	327	304	369	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
IFT57	Q9NWB7	283	327	293	293	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL1R2	P27930	229	250	14	398	Chain	ID=PRO_0000015439;Note=Interleukin-1 receptor type 2%2C membrane form
IL1R2	P27930	229	250	14	398	Chain	ID=PRO_0000015439;Note=Interleukin-1 receptor type 2%2C membrane form
IL1R2	P27930	229	250	14	343	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL1R2	P27930	229	250	14	343	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL1R2	P27930	229	250	237	349	Domain	Note=Ig-like C2-type 3
IL1R2	P27930	229	250	237	349	Domain	Note=Ig-like C2-type 3
IL1R2	P27930	229	250	219	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O4O
IL1R2	P27930	229	250	219	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O4O
IL6ST	P40189	21	123	1	22	Signal peptide	.
IL6ST	P40189	21	123	1	22	Signal peptide	.
IL6ST	P40189	21	123	1	22	Signal peptide	.
IL6ST	P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
IL6ST	P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IL6ST	P40189	21	123	26	120	Domain	Note=Ig-like C2-type
IL6ST	P40189	21	123	26	120	Domain	Note=Ig-like C2-type
IL6ST	P40189	21	123	26	120	Domain	Note=Ig-like C2-type
IL6ST	P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
IL6ST	P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11098061;Dbxref=PMID:11098061
IL6ST	P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11098061;Dbxref=PMID:11098061
IL6ST	P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11098061;Dbxref=PMID:11098061
IL6ST	P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11098061,ECO:0000269|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
IL6ST	P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10880057;Dbxref=PMID:10880057
IL6ST	P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL6ST	P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL6ST	P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL6ST	P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL6ST	P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL6ST	P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IL6ST	P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
IL6ST	P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
IL6ST	P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
IL6ST	P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
IL6ST	P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
IL6ST	P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
IL6ST	P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I1R
IL6ST	P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
IL6ST	P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L5I
EIF5B	O60841	462	492	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	492	517	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	757	801	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	801	862	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	862	916	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	757	801	629	846	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	801	862	629	846	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	757	801	756	759	Region	Note=G4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	801	862	824	826	Region	Note=G5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	462	492	491	496	Compositional bias	Note=Poly-Glu
EIF5B	O60841	492	517	491	496	Compositional bias	Note=Poly-Glu
EIF5B	O60841	492	517	498	498	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
EIF5B	O60841	757	801	759	759	Mutagenesis	Note=Loss of activity%3B both in vivo and in vitro. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200264;Dbxref=PMID:10200264
EIF5B	O60841	862	916	894	894	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	53	140	1	519	Chain	ID=PRO_0000047094;Note=DNA-binding protein Ikaros
IKZF1	Q13422	196	238	1	519	Chain	ID=PRO_0000047094;Note=DNA-binding protein Ikaros
IKZF1	Q13422	238	283	1	519	Chain	ID=PRO_0000047094;Note=DNA-binding protein Ikaros
IKZF1	Q13422	53	140	117	139	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
IKZF1	Q13422	196	238	201	224	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
IKZF1	Q13422	53	140	63	63	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
IKZF1	Q13422	53	140	101	101	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q03267
IKZF1	Q13422	53	140	140	140	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q03267
IKZF1	Q13422	196	238	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q03267
IKZF1	Q13422	238	283	258	258	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
IKZF1	Q13422	238	283	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
IKZF1	Q13422	53	140	58	58	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000250;evidence=ECO:0000250
IKZF1	Q13422	238	283	241	241	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000250;evidence=ECO:0000250
IKZF1	Q13422	53	140	10	53	Alternative sequence	ID=VSP_006847;Note=In isoform Ik4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	53	140	54	283	Alternative sequence	ID=VSP_006849;Note=In isoform Ik6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	196	238	54	283	Alternative sequence	ID=VSP_006849;Note=In isoform Ik6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	238	283	54	283	Alternative sequence	ID=VSP_006849;Note=In isoform Ik6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	53	140	54	140	Alternative sequence	ID=VSP_006848;Note=In isoform Ik2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IKZF1	Q13422	196	238	141	283	Alternative sequence	ID=VSP_006852;Note=In isoform Ik5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	238	283	141	283	Alternative sequence	ID=VSP_006852;Note=In isoform Ik5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	196	238	197	283	Alternative sequence	ID=VSP_006850;Note=In isoform Ik3 and isoform Ik4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	238	283	197	283	Alternative sequence	ID=VSP_006850;Note=In isoform Ik3 and isoform Ik4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	196	238	197	238	Alternative sequence	ID=VSP_006851;Note=In isoform Ik7 and isoform Ikx. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3,ECO:0000303|Ref.5;Dbxref=PMID:15489334
IKZF1	Q13422	238	283	197	238	Alternative sequence	ID=VSP_006851;Note=In isoform Ik7 and isoform Ikx. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3,ECO:0000303|Ref.5;Dbxref=PMID:15489334
IKZF1	Q13422	238	283	260	268	Alternative sequence	ID=VSP_053404;Note=In isoform Ikx. RSLVLDRLA->ISRAGQTSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IKZF1	Q13422	238	283	269	519	Alternative sequence	ID=VSP_053405;Note=In isoform Ikx. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
IKZF1	Q13422	196	238	210	210	Natural variant	ID=VAR_076405;Note=In CVID13%3B decreases binding to pericentromeric heterochromatin DNA%3B has diffuse nuclear localization. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21548011,ECO:0000269|PubMed:26981933;Dbxref=dbSNP:rs869312883,PMID:21548011,PMID:26981933
IKZF1	Q13422	196	238	214	214	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
IKZF1	Q13422	238	283	245	245	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL33	O95760	30	72	1	270	Chain	ID=PRO_0000096790;Note=Interleukin-33
IL33	O95760	72	114	1	270	Chain	ID=PRO_0000096790;Note=Interleukin-33
IL33	O95760	114	156	1	270	Chain	ID=PRO_0000096790;Note=Interleukin-33
IL33	O95760	30	72	1	94	Propeptide	ID=PRO_0000430083;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
IL33	O95760	72	114	1	94	Propeptide	ID=PRO_0000430083;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
IL33	O95760	72	114	95	270	Chain	ID=PRO_0000430084;Note=Interleukin-33 (95-270)
IL33	O95760	114	156	95	270	Chain	ID=PRO_0000430084;Note=Interleukin-33 (95-270)
IL33	O95760	72	114	99	270	Chain	ID=PRO_0000430085;Note=Interleukin-33 (99-270)
IL33	O95760	114	156	99	270	Chain	ID=PRO_0000430085;Note=Interleukin-33 (99-270)
IL33	O95760	72	114	109	270	Chain	ID=PRO_0000430086;Note=Interleukin-33 (109-270)
IL33	O95760	114	156	109	270	Chain	ID=PRO_0000430086;Note=Interleukin-33 (109-270)
IL33	O95760	30	72	1	65	Region	Note=Homeodomain-like HTH domain
IL33	O95760	30	72	66	111	Region	Note=Interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250
IL33	O95760	72	114	66	111	Region	Note=Interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250
IL33	O95760	72	114	94	95	Site	Note=Cleavage%3B by CTSG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
IL33	O95760	72	114	98	99	Site	Note=Cleavage%3B by ELANE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
IL33	O95760	72	114	108	109	Site	Note=Cleavage%3B by CTSG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
IL33	O95760	30	72	31	157	Alternative sequence	ID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IL33	O95760	72	114	31	157	Alternative sequence	ID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IL33	O95760	114	156	31	157	Alternative sequence	ID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IL33	O95760	30	72	72	113	Alternative sequence	ID=VSP_044948;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21454686;Dbxref=PMID:21454686
IL33	O95760	72	114	72	113	Alternative sequence	ID=VSP_044948;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21454686;Dbxref=PMID:21454686
IL33	O95760	114	156	115	156	Alternative sequence	ID=VSP_042728;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IL33	O95760	114	156	144	144	Mutagenesis	Note=Decreases affinity for IL1RL1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
IL33	O95760	114	156	148	148	Mutagenesis	Note=7-fold decrease in affinity for IL1RL1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
IL33	O95760	114	156	149	149	Mutagenesis	Note=Almost abolishes binding to IL1RL1. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
IL33	O95760	114	156	139	139	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
IL33	O95760	72	114	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
IL33	O95760	114	156	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
IL33	O95760	114	156	119	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
IL33	O95760	114	156	129	131	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
IL33	O95760	114	156	133	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
IL33	O95760	114	156	140	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
IL6	P05231	108	157	30	212	Chain	ID=PRO_0000015582;Note=Interleukin-6
IL6	P05231	108	157	30	212	Chain	ID=PRO_0000015582;Note=Interleukin-6
IL6	P05231	108	157	101	111	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2472117;Dbxref=PMID:2472117
IL6	P05231	108	157	101	111	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2472117;Dbxref=PMID:2472117
IL6	P05231	108	157	108	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IL6	P05231	108	157	108	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IL6	P05231	108	157	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J4L
IL6	P05231	108	157	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J4L
IL6	P05231	108	157	137	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IL6	P05231	108	157	137	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IGFN1	Q86VF2	258	358	1	1251	Chain	ID=PRO_0000347186;Note=Immunoglobulin-like and fibronectin type III domain-containing protein 1
IGFN1	Q86VF2	416	459	1	1251	Chain	ID=PRO_0000347186;Note=Immunoglobulin-like and fibronectin type III domain-containing protein 1
IGFN1	Q86VF2	459	560	1	1251	Chain	ID=PRO_0000347186;Note=Immunoglobulin-like and fibronectin type III domain-containing protein 1
IGFN1	Q86VF2	258	358	309	398	Domain	Note=Ig-like 2
IGFN1	Q86VF2	416	459	454	539	Domain	Note=Ig-like 3
IGFN1	Q86VF2	459	560	454	539	Domain	Note=Ig-like 3
IGFN1	Q86VF2	258	358	1	383	Alternative sequence	ID=VSP_035055;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:15489334,PMID:17974005
ACO2	Q99798	278	313	28	780	Chain	ID=PRO_0000000541;Note=Aconitate hydratase%2C mitochondrial
ACO2	Q99798	494	535	28	780	Chain	ID=PRO_0000000541;Note=Aconitate hydratase%2C mitochondrial
ACO2	Q99798	587	651	28	780	Chain	ID=PRO_0000000541;Note=Aconitate hydratase%2C mitochondrial
ACO2	Q99798	587	651	607	607	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACO2	Q99798	587	651	591	591	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KI0
ACO2	Q99798	587	651	605	605	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACO2	Q99798	587	651	605	605	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KI0
ACO2	Q99798	587	651	628	628	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KI0
ACO2	Q99798	494	535	517	517	Sequence conflict	Note=T->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACSL1	P33121	594	628	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	421	453	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	305	331	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	252	263	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	125	159	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	594	628	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	421	453	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	305	331	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	252	263	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	125	159	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	594	628	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	421	453	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	305	331	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	252	263	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	125	159	1	698	Chain	ID=PRO_0000193104;Note=Long-chain-fatty-acid--CoA ligase 1
ACSL1	P33121	594	628	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	421	453	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	305	331	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	252	263	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	125	159	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	594	628	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	421	453	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	305	331	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	252	263	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	125	159	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	594	628	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	421	453	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	305	331	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	252	263	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	125	159	46	698	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL1	P33121	594	628	620	620	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ACSL1	P33121	594	628	620	620	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ACSL1	P33121	594	628	620	620	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ACSL1	P33121	125	159	135	135	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSL1	P33121	125	159	135	135	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSL1	P33121	125	159	135	135	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSL1	P33121	305	331	306	331	Alternative sequence	ID=VSP_054391;Note=In isoform 3. NTVNPCPDDTLISFLPLAHMFERVVE->KALPLSASDTHISYLPLAHIYEQLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACSL1	P33121	305	331	306	331	Alternative sequence	ID=VSP_054391;Note=In isoform 3. NTVNPCPDDTLISFLPLAHMFERVVE->KALPLSASDTHISYLPLAHIYEQLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACSL1	P33121	305	331	306	331	Alternative sequence	ID=VSP_054391;Note=In isoform 3. NTVNPCPDDTLISFLPLAHMFERVVE->KALPLSASDTHISYLPLAHIYEQLLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACSM2B	Q68CK6	199	246	47	577	Chain	ID=PRO_0000306094;Note=Acyl-coenzyme A synthetase ACSM2B%2C mitochondrial
ACSM2B	Q68CK6	199	246	47	577	Chain	ID=PRO_0000306094;Note=Acyl-coenzyme A synthetase ACSM2B%2C mitochondrial
ACSM2B	Q68CK6	199	246	47	577	Chain	ID=PRO_0000306094;Note=Acyl-coenzyme A synthetase ACSM2B%2C mitochondrial
ACSM2B	Q68CK6	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSM2B	Q68CK6	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSM2B	Q68CK6	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACVR1B	P36896	193	270	24	505	Chain	ID=PRO_0000024417;Note=Activin receptor type-1B
ACVR1B	P36896	270	326	24	505	Chain	ID=PRO_0000024417;Note=Activin receptor type-1B
ACVR1B	P36896	193	270	150	505	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1B	P36896	270	326	150	505	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1B	P36896	193	270	177	206	Domain	Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585
ACVR1B	P36896	193	270	207	497	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1B	P36896	270	326	207	497	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1B	P36896	193	270	213	221	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1B	P36896	193	270	234	234	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1B	P36896	270	326	271	271	Alternative sequence	ID=VSP_041842;Note=In isoform 4. D->ADCSFLTLPWEVVMVSAAPKLRSLRLQYKGGRGRARFLFPLN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACVR1B	P36896	193	270	206	206	Mutagenesis	Note=Leads to constitutive activation. T->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8622651;Dbxref=PMID:8622651
ACVR1B	P36896	193	270	222	223	Sequence conflict	Note=WR->MA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACVR1B	P36896	193	270	222	223	Sequence conflict	Note=WR->MA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADAM10	O14672	195	245	20	213	Propeptide	ID=PRO_0000029066;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741
ADAM10	O14672	108	161	20	213	Propeptide	ID=PRO_0000029066;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741
ADAM10	O14672	245	276	214	748	Chain	ID=PRO_0000029067;Note=Disintegrin and metalloproteinase domain-containing protein 10
ADAM10	O14672	195	245	214	748	Chain	ID=PRO_0000029067;Note=Disintegrin and metalloproteinase domain-containing protein 10
ADAM10	O14672	245	276	20	672	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM10	O14672	195	245	20	672	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM10	O14672	108	161	20	672	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM10	O14672	245	276	220	456	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM10	O14672	195	245	220	456	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM10	O14672	195	245	213	214	Site	Note=Cleavage%3B by furin and PCSK7;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741
ADAM10	O14672	245	276	267	267	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM10	O14672	245	276	222	313	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BDZ,ECO:0000244|PDB:6BE6,ECO:0000269|PubMed:29224781;Dbxref=PMID:29224781
ADAM10	O14672	195	245	222	313	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BDZ,ECO:0000244|PDB:6BE6,ECO:0000269|PubMed:29224781;Dbxref=PMID:29224781
ADAM10	O14672	245	276	19	319	Alternative sequence	ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAM10	O14672	195	245	19	319	Alternative sequence	ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAM10	O14672	108	161	19	319	Alternative sequence	ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAM10	O14672	108	161	139	139	Natural variant	ID=VAR_070907;Note=In RAK. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23666529;Dbxref=dbSNP:rs483352912,PMID:23666529
ADAM10	O14672	195	245	212	212	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADAM10	O14672	195	245	219	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6
ADAM10	O14672	195	245	230	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6
ADAM10	O14672	245	276	239	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6
ADAM10	O14672	195	245	239	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6
ADAM10	O14672	245	276	269	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6
ADAM17	P78536	397	448	215	824	Chain	ID=PRO_0000029089;Note=Disintegrin and metalloproteinase domain-containing protein 17
ADAM17	P78536	251	281	215	824	Chain	ID=PRO_0000029089;Note=Disintegrin and metalloproteinase domain-containing protein 17
ADAM17	P78536	397	448	215	671	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM17	P78536	251	281	215	671	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM17	P78536	397	448	223	474	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM17	P78536	251	281	223	474	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM17	P78536	397	448	406	406	Active site	Ontology_term=ECO:0000255,ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00276,ECO:0000255|PROSITE-ProRule:PRU10095,ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	397	448	405	405	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	397	448	409	409	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	397	448	415	415	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	251	281	264	264	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM17	P78536	251	281	225	333	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	397	448	365	469	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	397	448	423	453	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9520379;Dbxref=PMID:9520379
ADAM17	P78536	251	281	244	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADAM17	P78536	251	281	269	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADAM17	P78536	251	281	276	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADAM17	P78536	397	448	396	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADAM17	P78536	397	448	418	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKI
ADAM17	P78536	397	448	421	423	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADAM17	P78536	397	448	427	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADAM17	P78536	397	448	436	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKI
ADAM17	P78536	397	448	442	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LGP
ADAM17	P78536	397	448	445	448	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DDF
ADH7	P40394	200	287	1	386	Chain	ID=PRO_0000160691;Note=Alcohol dehydrogenase class 4 mu/sigma chain
ADH7	P40394	200	287	211	216	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10631979;Dbxref=PMID:10631979
ADH7	P40394	200	287	235	235	Binding site	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10631979;Dbxref=PMID:10631979
ADH7	P40394	200	287	240	240	Binding site	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10631979;Dbxref=PMID:10631979
ADH7	P40394	200	287	217	217	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADH7	P40394	200	287	206	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	214	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	241	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	250	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	262	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	276	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH7	P40394	200	287	284	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D1T
ADH5	P11766	188	275	2	374	Chain	ID=PRO_0000160759;Note=Alcohol dehydrogenase class-3
ADH5	P11766	188	275	233	233	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P28474
ADH5	P11766	188	275	247	247	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ADH5	P11766	188	275	246	246	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADH5	P11766	188	275	194	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	202	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	217	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	226	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	229	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	238	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	243	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	250	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	262	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
ADH5	P11766	188	275	272	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FZW
MAMDC4	Q6UXC1	15	51	1	22	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAMDC4	Q6UXC1	15	51	23	1216	Chain	ID=PRO_0000286578;Note=Apical endosomal glycoprotein
MAMDC4	Q6UXC1	1019	1064	23	1216	Chain	ID=PRO_0000286578;Note=Apical endosomal glycoprotein
MAMDC4	Q6UXC1	15	51	23	1151	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAMDC4	Q6UXC1	1019	1064	23	1151	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MAMDC4	Q6UXC1	15	51	26	53	Domain	Note=LDL-receptor class A 1%3B truncated;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
MAMDC4	Q6UXC1	1019	1064	971	1138	Domain	Note=MAM 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00128
MAMDC4	Q6UXC1	1019	1064	961	1216	Alternative sequence	ID=VSP_026432;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AGAP5	A6NIR3	97	120	1	686	Chain	ID=PRO_0000349205;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 5
AGAP5	A6NIR3	97	120	1	686	Chain	ID=PRO_0000349205;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 5
AKIRIN1	Q9H9L7	120	165	1	192	Chain	ID=PRO_0000274318;Note=Akirin-1
AKIRIN1	Q9H9L7	165	189	1	192	Chain	ID=PRO_0000274318;Note=Akirin-1
AKIRIN1	Q9H9L7	120	165	121	165	Alternative sequence	ID=VSP_042769;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKIRIN1	Q9H9L7	165	189	121	165	Alternative sequence	ID=VSP_042769;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AGO3	Q9H9G7	219	264	1	860	Chain	ID=PRO_0000194061;Note=Protein argonaute-3
AGO3	Q9H9G7	679	724	1	860	Chain	ID=PRO_0000194061;Note=Protein argonaute-3
AGO3	Q9H9G7	219	264	236	349	Domain	Note=PAZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03032
AGO3	Q9H9G7	679	724	518	819	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03032
AGO3	Q9H9G7	219	264	1	234	Alternative sequence	ID=VSP_041084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGO3	Q9H9G7	219	264	213	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	219	264	231	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	219	264	253	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	677	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	693	695	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	702	707	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	716	719	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	721	723	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AKR1E2	Q96JD6	13	69	1	320	Chain	ID=PRO_0000287880;Note=1%2C5-anhydro-D-fructose reductase
AKR1E2	Q96JD6	69	108	1	320	Chain	ID=PRO_0000287880;Note=1%2C5-anhydro-D-fructose reductase
AKR1E2	Q96JD6	153	194	1	320	Chain	ID=PRO_0000287880;Note=1%2C5-anhydro-D-fructose reductase
AKR1E2	Q96JD6	13	69	40	40	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60218
AKR1E2	Q96JD6	13	69	35	35	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60218
AKR1E2	Q96JD6	69	108	102	102	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60218
AKR1E2	Q96JD6	153	194	194	194	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60218
AKR1E2	Q96JD6	13	69	69	69	Site	Note=Lowers pKa of active site Tyr;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14550
AKR1E2	Q96JD6	69	108	69	69	Site	Note=Lowers pKa of active site Tyr;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14550
AKR1E2	Q96JD6	153	194	154	251	Alternative sequence	ID=VSP_025614;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12604216;Dbxref=PMID:12604216
AKR1E2	Q96JD6	153	194	194	250	Alternative sequence	ID=VSP_025615;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12604216;Dbxref=PMID:12604216
AKR1E2	Q96JD6	13	69	52	52	Natural variant	ID=VAR_032356;Note=C->G;Dbxref=dbSNP:rs35429729
AKR1E2	Q96JD6	69	108	86	86	Natural variant	ID=VAR_032357;Note=K->R;Dbxref=dbSNP:rs17133693
ANKDD1B	A6NHY2	99	132	1	528	Chain	ID=PRO_0000332160;Note=Ankyrin repeat and death domain-containing protein 1B
ANKDD1B	A6NHY2	233	266	1	528	Chain	ID=PRO_0000332160;Note=Ankyrin repeat and death domain-containing protein 1B
ANKDD1B	A6NHY2	266	299	1	528	Chain	ID=PRO_0000332160;Note=Ankyrin repeat and death domain-containing protein 1B
ANKDD1B	A6NHY2	299	332	1	528	Chain	ID=PRO_0000332160;Note=Ankyrin repeat and death domain-containing protein 1B
ANKDD1B	A6NHY2	464	508	1	528	Chain	ID=PRO_0000332160;Note=Ankyrin repeat and death domain-containing protein 1B
ANKDD1B	A6NHY2	99	132	100	129	Repeat	Note=ANK 2
ANKDD1B	A6NHY2	233	266	234	263	Repeat	Note=ANK 6
ANKDD1B	A6NHY2	266	299	267	296	Repeat	Note=ANK 7
ANKDD1B	A6NHY2	299	332	300	329	Repeat	Note=ANK 8
ANKDD1B	A6NHY2	464	508	427	515	Domain	Note=Death;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00064
GPT2	Q8TD30	81	111	1	523	Chain	ID=PRO_0000247532;Note=Alanine aminotransferase 2
GPT2	Q8TD30	404	456	1	523	Chain	ID=PRO_0000247532;Note=Alanine aminotransferase 2
GPT2	Q8TD30	404	456	415	415	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGT5
GPT2	Q8TD30	81	111	1	100	Alternative sequence	ID=VSP_020008;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GPT2	Q8TD30	81	111	86	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHJ
GPT2	Q8TD30	81	111	107	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHJ
GPT2	Q8TD30	404	456	399	425	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHJ
GPT2	Q8TD30	404	456	437	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHJ
GPT2	Q8TD30	404	456	449	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHJ
AKT2	P31751	277	320	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
AKT2	P31751	213	236	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
AKT2	P31751	191	213	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
AKT2	P31751	277	320	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT2	P31751	213	236	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT2	P31751	191	213	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT2	P31751	213	236	230	232	Region	Note=Inhibitor binding
AKT2	P31751	277	320	277	279	Region	Note=Inhibitor binding
AKT2	P31751	277	320	292	293	Region	Note=Inhibitor binding
AKT2	P31751	277	320	280	280	Metal binding	Note=Manganese;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12434148;Dbxref=PMID:12434148
AKT2	P31751	277	320	293	293	Metal binding	Note=Manganese;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12434148;Dbxref=PMID:12434148
AKT2	P31751	191	213	200	200	Binding site	Note=Inhibitor
AKT2	P31751	213	236	232	232	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT2	P31751	213	236	236	236	Binding site	Note=Inhibitor
AKT2	P31751	277	320	279	279	Binding site	Note=Inhibitor%3B via carbonyl oxygen
AKT2	P31751	277	320	293	293	Binding site	Note=Inhibitor
AKT2	P31751	277	320	294	294	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT2	P31751	277	320	309	309	Modified residue	Note=Phosphothreonine%3B by PDPK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12434148,ECO:0000269|PubMed:15890450,ECO:0000269|PubMed:20059950,ECO:0000269|PubMed:9512493;Dbxref=PMID:12434148,PMID:15890450,PMID:20059950,PMID:9512493
AKT2	P31751	277	320	306	306	Glycosylation	Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKT2	P31751	277	320	313	313	Glycosylation	Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKT2	P31751	277	320	297	311	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12517337;Dbxref=PMID:12517337
AKT2	P31751	277	320	278	320	Alternative sequence	ID=VSP_056930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AKT2	P31751	191	213	208	208	Natural variant	ID=VAR_040357;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35817154,PMID:17344846
AKT2	P31751	277	320	309	309	Mutagenesis	Note=Impairs interaction with TTC3%3B when associated with A-474. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15890450,ECO:0000269|PubMed:20059950;Dbxref=PMID:15890450,PMID:20059950
AKT2	P31751	277	320	309	309	Mutagenesis	Note=Constitutively active%3B when associated with D-474. T->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15890450,ECO:0000269|PubMed:20059950;Dbxref=PMID:15890450,PMID:20059950
AKT2	P31751	191	213	194	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	213	236	215	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	213	236	222	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	280	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	298	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UW9
AKT2	P31751	277	320	310	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDO
AKT2	P31751	277	320	314	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	319	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
YWHAQ	P27348	194	226	1	245	Chain	ID=PRO_0000058636;Note=14-3-3 protein theta
YWHAQ	P27348	194	226	1	245	Chain	ID=PRO_0000058636;Note=14-3-3 protein theta
YWHAQ	P27348	194	226	185	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	185	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	202	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	202	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	211	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
YWHAQ	P27348	194	226	211	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQP
PPP2R1A	P30153	331	376	2	589	Chain	ID=PRO_0000071400;Note=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
PPP2R1A	P30153	376	434	2	589	Chain	ID=PRO_0000071400;Note=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
PPP2R1A	P30153	331	376	322	360	Repeat	Note=HEAT 9
PPP2R1A	P30153	331	376	361	399	Repeat	Note=HEAT 10
PPP2R1A	P30153	376	434	361	399	Repeat	Note=HEAT 10
PPP2R1A	P30153	376	434	400	438	Repeat	Note=HEAT 11
PPP2R1A	P30153	331	376	8	399	Region	Note=PP2A subunit B binding
PPP2R1A	P30153	376	434	8	399	Region	Note=PP2A subunit B binding
PPP2R1A	P30153	376	434	400	589	Region	Note=PP2A subunit C binding
PPP2R1A	P30153	331	376	326	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	331	376	339	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	331	376	349	352	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	331	376	353	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	331	376	358	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	331	376	366	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	376	434	378	385	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	376	434	389	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	376	434	397	412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
PPP2R1A	P30153	376	434	417	434	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B3U
SH3BP1	Q9Y3L3	34	69	1	701	Chain	ID=PRO_0000056723;Note=SH3 domain-binding protein 1
SH3BP1	Q9Y3L3	206	229	1	701	Chain	ID=PRO_0000056723;Note=SH3 domain-binding protein 1
SH3BP1	Q9Y3L3	373	399	1	701	Chain	ID=PRO_0000056723;Note=SH3 domain-binding protein 1
SH3BP1	Q9Y3L3	400	438	1	701	Chain	ID=PRO_0000056723;Note=SH3 domain-binding protein 1
SH3BP1	Q9Y3L3	34	69	17	262	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3BP1	Q9Y3L3	206	229	17	262	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3BP1	Q9Y3L3	373	399	276	469	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
SH3BP1	Q9Y3L3	400	438	276	469	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
SH3BP1	Q9Y3L3	34	69	1	275	Region	Note=Interaction with CGNL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22891260;Dbxref=PMID:22891260
SH3BP1	Q9Y3L3	206	229	1	275	Region	Note=Interaction with CGNL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22891260;Dbxref=PMID:22891260
ABHD17B	Q5VST6	156	215	1	288	Chain	ID=PRO_0000281111;Note=Alpha/beta hydrolase domain-containing protein 17B
ABHD17B	Q5VST6	156	215	170	170	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96GS6
ABHD17B	Q5VST6	156	215	169	169	Natural variant	ID=VAR_031230;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854317,PMID:15489334
ABHD17B	Q5VST6	156	215	207	207	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABTB1	Q969K4	175	214	1	478	Chain	ID=PRO_0000248267;Note=Ankyrin repeat and BTB/POZ domain-containing protein 1
ABTB1	Q969K4	254	287	1	478	Chain	ID=PRO_0000248267;Note=Ankyrin repeat and BTB/POZ domain-containing protein 1
ABTB1	Q969K4	287	343	1	478	Chain	ID=PRO_0000248267;Note=Ankyrin repeat and BTB/POZ domain-containing protein 1
ABTB1	Q969K4	175	214	115	182	Domain	Note=BTB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ABTB1	Q969K4	254	287	272	346	Domain	Note=BTB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ABTB1	Q969K4	287	343	272	346	Domain	Note=BTB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ABTB1	Q969K4	175	214	87	196	Alternative sequence	ID=VSP_052151;Note=In isoform 4. DYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQ->LCGHEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABTB1	Q969K4	254	287	255	287	Alternative sequence	ID=VSP_052152;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABTB1	Q969K4	287	343	255	287	Alternative sequence	ID=VSP_052152;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABHD3	Q8WU67	223	280	1	409	Chain	ID=PRO_0000280208;Note=Phospholipase ABHD3
ABHD3	Q8WU67	223	280	140	233	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD3	Q8WU67	223	280	137	409	Alternative sequence	ID=VSP_056138;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACOX2	Q99424	449	508	1	681	Chain	ID=PRO_0000204681;Note=Peroxisomal acyl-coenzyme A oxidase 2
ACOX2	Q99424	194	234	1	681	Chain	ID=PRO_0000204681;Note=Peroxisomal acyl-coenzyme A oxidase 2
ACOX2	Q99424	449	508	453	453	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXD1
ACOX2	Q99424	449	508	69	681	Natural variant	ID=VAR_078764;Note=In CBAS6%3B patient liver samples show absence of the protein%3B complete loss of fatty acid beta-oxidation activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27647924;Dbxref=PMID:27647924
ACOX2	Q99424	194	234	69	681	Natural variant	ID=VAR_078764;Note=In CBAS6%3B patient liver samples show absence of the protein%3B complete loss of fatty acid beta-oxidation activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27647924;Dbxref=PMID:27647924
ACOX2	Q99424	194	234	225	225	Natural variant	ID=VAR_078765;Note=In CBAS6%3B reduces fatty acid beta-oxidation activity%3B does not alter subcellular location. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27884763;Dbxref=dbSNP:rs150832314,PMID:27884763
ACTR1A	P61163	219	250	1	376	Chain	ID=PRO_0000089058;Note=Alpha-centractin
ACVR1C	Q8NER5	181	258	21	493	Chain	ID=PRO_0000042628;Note=Activin receptor type-1C
ACVR1C	Q8NER5	101	181	21	493	Chain	ID=PRO_0000042628;Note=Activin receptor type-1C
ACVR1C	Q8NER5	101	181	22	113	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1C	Q8NER5	101	181	114	134	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1C	Q8NER5	181	258	135	493	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1C	Q8NER5	101	181	135	493	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1C	Q8NER5	181	258	165	194	Domain	Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585
ACVR1C	Q8NER5	101	181	165	194	Domain	Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585
ACVR1C	Q8NER5	181	258	195	485	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1C	Q8NER5	181	258	201	209	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q04771,ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1C	Q8NER5	181	258	222	222	Binding site	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q04771,ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1C	Q8NER5	181	258	102	258	Alternative sequence	ID=VSP_051841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12606401;Dbxref=PMID:12606401
ACVR1C	Q8NER5	101	181	102	258	Alternative sequence	ID=VSP_051841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12606401;Dbxref=PMID:12606401
ACVR1C	Q8NER5	181	258	102	181	Alternative sequence	ID=VSP_051842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12606401;Dbxref=PMID:12606401
ACVR1C	Q8NER5	101	181	102	181	Alternative sequence	ID=VSP_051842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12606401;Dbxref=PMID:12606401
ACVR1C	Q8NER5	181	258	195	195	Natural variant	ID=VAR_041407;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56188432,PMID:17344846
ACVR1C	Q8NER5	181	258	216	216	Natural variant	ID=VAR_041408;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34742924,PMID:17344846
ACVR1C	Q8NER5	181	258	194	194	Mutagenesis	Note=Pro-apoptotic. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15531507;Dbxref=PMID:15531507
ACVR1C	Q8NER5	181	258	222	222	Mutagenesis	Note=Loss of response to NODAL and SMAD2 phosphorylation. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12063393,ECO:0000269|PubMed:15531507;Dbxref=PMID:12063393,PMID:15531507
ACVR1C	Q8NER5	181	258	231	231	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACTG2	P63267	42	85	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	85	122	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	150	204	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	204	268	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	42	85	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	85	122	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	150	204	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	204	268	2	376	Chain	ID=PRO_0000442949;Note=Actin%2C gamma-enteric smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTG2	P63267	42	85	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	85	122	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	150	204	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	204	268	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	42	85	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	85	122	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	150	204	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	204	268	3	376	Chain	ID=PRO_0000442950;Note=Actin%2C gamma-enteric smooth muscle
ACTG2	P63267	42	85	45	45	Modified residue	Note=Methionine (R)-sulfoxide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63268
ACTG2	P63267	42	85	45	45	Modified residue	Note=Methionine (R)-sulfoxide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63268
ACTG2	P63267	42	85	48	48	Modified residue	Note=Methionine (R)-sulfoxide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63268
ACTG2	P63267	42	85	48	48	Modified residue	Note=Methionine (R)-sulfoxide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63268
ACTG2	P63267	42	85	51	51	Cross-link	Note=Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-271)%3B by Vibrio toxins RtxA and VgrG1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60709
ACTG2	P63267	42	85	51	51	Cross-link	Note=Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-271)%3B by Vibrio toxins RtxA and VgrG1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60709
ACTG2	P63267	42	85	43	85	Alternative sequence	ID=VSP_045861;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTG2	P63267	85	122	43	85	Alternative sequence	ID=VSP_045861;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTG2	P63267	42	85	43	85	Alternative sequence	ID=VSP_045861;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTG2	P63267	85	122	43	85	Alternative sequence	ID=VSP_045861;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTG2	P63267	42	85	45	45	Natural variant	ID=VAR_071281;Note=In VSCM. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs864309490,PMID:24676022
ACTG2	P63267	42	85	45	45	Natural variant	ID=VAR_071281;Note=In VSCM. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs864309490,PMID:24676022
ACTG2	P63267	42	85	63	63	Natural variant	ID=VAR_071282;Note=In VSCM. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs864309491,PMID:24676022
ACTG2	P63267	42	85	63	63	Natural variant	ID=VAR_071282;Note=In VSCM. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs864309491,PMID:24676022
ACTG2	P63267	85	122	110	110	Natural variant	ID=VAR_071283;Note=In VSCM. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=PMID:24676022
ACTG2	P63267	85	122	110	110	Natural variant	ID=VAR_071283;Note=In VSCM. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=PMID:24676022
ACTG2	P63267	150	204	178	178	Natural variant	ID=VAR_071286;Note=In VSCM%3B interferes with proper polymerization into thin filaments leading to impaired contractility of the smooth muscle. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24337657,ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs78001248,PMID:24337657,PMID:24676022
ACTG2	P63267	150	204	178	178	Natural variant	ID=VAR_071286;Note=In VSCM%3B interferes with proper polymerization into thin filaments leading to impaired contractility of the smooth muscle. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24337657,ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs78001248,PMID:24337657,PMID:24676022
ACTG2	P63267	150	204	178	178	Natural variant	ID=VAR_071287;Note=In VSCM. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs587777384,PMID:24676022
ACTG2	P63267	150	204	178	178	Natural variant	ID=VAR_071287;Note=In VSCM. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs587777384,PMID:24676022
ACTG2	P63267	150	204	178	178	Natural variant	ID=VAR_071288;Note=In VSCM%3B interferes with proper polymerization into thin filaments leading to impaired contractility of the smooth muscle. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24337657;Dbxref=dbSNP:rs587777384,PMID:24337657
ACTG2	P63267	150	204	178	178	Natural variant	ID=VAR_071288;Note=In VSCM%3B interferes with proper polymerization into thin filaments leading to impaired contractility of the smooth muscle. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24337657;Dbxref=dbSNP:rs587777384,PMID:24337657
ACTG2	P63267	150	204	198	198	Natural variant	ID=VAR_071289;Note=In VSCM. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs864309492,PMID:24676022
ACTG2	P63267	150	204	198	198	Natural variant	ID=VAR_071289;Note=In VSCM. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs864309492,PMID:24676022
ACTG2	P63267	204	268	257	257	Natural variant	ID=VAR_071290;Note=In VSCM. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs587777387,PMID:24676022
ACTG2	P63267	204	268	257	257	Natural variant	ID=VAR_071290;Note=In VSCM. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676022;Dbxref=dbSNP:rs587777387,PMID:24676022
ACTG2	P63267	150	204	157	157	Sequence conflict	Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACTG2	P63267	150	204	157	157	Sequence conflict	Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACVR1	Q04771	355	421	21	509	Chain	ID=PRO_0000024394;Note=Activin receptor type-1
ACVR1	Q04771	355	421	21	509	Chain	ID=PRO_0000024394;Note=Activin receptor type-1
ACVR1	Q04771	355	421	21	509	Chain	ID=PRO_0000024394;Note=Activin receptor type-1
ACVR1	Q04771	355	421	21	509	Chain	ID=PRO_0000024394;Note=Activin receptor type-1
ACVR1	Q04771	355	421	147	509	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1	Q04771	355	421	147	509	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1	Q04771	355	421	147	509	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1	Q04771	355	421	147	509	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR1	Q04771	355	421	208	502	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1	Q04771	355	421	208	502	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1	Q04771	355	421	208	502	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1	Q04771	355	421	208	502	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR1	Q04771	355	421	356	356	Natural variant	ID=VAR_058424;Note=In FOP%3B variant phenotype. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs121912679,PMID:19085907
ACVR1	Q04771	355	421	356	356	Natural variant	ID=VAR_058424;Note=In FOP%3B variant phenotype. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs121912679,PMID:19085907
ACVR1	Q04771	355	421	356	356	Natural variant	ID=VAR_058424;Note=In FOP%3B variant phenotype. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs121912679,PMID:19085907
ACVR1	Q04771	355	421	356	356	Natural variant	ID=VAR_058424;Note=In FOP%3B variant phenotype. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs121912679,PMID:19085907
ACVR1	Q04771	355	421	375	375	Natural variant	ID=VAR_058425;Note=In FOP%3B variant phenotype. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs387906590,PMID:19085907
ACVR1	Q04771	355	421	375	375	Natural variant	ID=VAR_058425;Note=In FOP%3B variant phenotype. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs387906590,PMID:19085907
ACVR1	Q04771	355	421	375	375	Natural variant	ID=VAR_058425;Note=In FOP%3B variant phenotype. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs387906590,PMID:19085907
ACVR1	Q04771	355	421	375	375	Natural variant	ID=VAR_058425;Note=In FOP%3B variant phenotype. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085907;Dbxref=dbSNP:rs387906590,PMID:19085907
ACVR1	Q04771	355	421	359	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	359	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	359	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	359	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	363	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	363	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	363	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	363	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	367	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	367	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	367	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	367	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	384	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	384	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	384	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	384	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	396	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	396	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	396	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ACVR1	Q04771	355	421	396	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q4U
ADAM11	O75078	495	522	226	769	Chain	ID=PRO_0000029075;Note=Disintegrin and metalloproteinase domain-containing protein 11
ADAM11	O75078	495	522	226	734	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM11	O75078	495	522	444	531	Domain	Note=Disintegrin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00068
ADAM11	O75078	495	522	503	523	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ACOX3	O15254	632	661	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	474	512	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	181	229	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	151	181	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	48	126	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	632	661	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	474	512	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	181	229	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	151	181	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	48	126	2	700	Chain	ID=PRO_0000204685;Note=Peroxisomal acyl-coenzyme A oxidase 3
ACOX3	O15254	632	661	625	700	Alternative sequence	ID=VSP_023356;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACOX3	O15254	632	661	625	700	Alternative sequence	ID=VSP_023356;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACOX3	O15254	474	512	497	497	Natural variant	ID=VAR_030803;Note=D->N;Dbxref=dbSNP:rs13434465
ACOX3	O15254	474	512	497	497	Natural variant	ID=VAR_030803;Note=D->N;Dbxref=dbSNP:rs13434465
ACOX3	O15254	48	126	95	95	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACOX3	O15254	48	126	95	95	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACSL5	Q9ULC5	361	406	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	406	438	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	613	637	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	361	406	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	406	438	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	613	637	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	361	406	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	406	438	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	613	637	1	683	Chain	ID=PRO_0000193112;Note=Long-chain-fatty-acid--CoA ligase 5
ACSL5	Q9ULC5	361	406	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	406	438	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	613	637	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	361	406	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	406	438	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	613	637	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	361	406	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	406	438	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	613	637	33	683	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL5	Q9ULC5	361	406	361	361	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZR0
ACSL5	Q9ULC5	361	406	361	361	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZR0
ACSL5	Q9ULC5	361	406	361	361	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZR0
ACSL5	Q9ULC5	613	637	614	637	Alternative sequence	ID=VSP_038233;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17681178;Dbxref=PMID:17681178
ACSL5	Q9ULC5	613	637	614	637	Alternative sequence	ID=VSP_038233;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17681178;Dbxref=PMID:17681178
ACSL5	Q9ULC5	613	637	614	637	Alternative sequence	ID=VSP_038233;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17681178;Dbxref=PMID:17681178
ACSL5	Q9ULC5	361	406	388	388	Natural variant	ID=VAR_036377;Note=In a colorectal cancer sample%3B somatic mutation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ACSL5	Q9ULC5	361	406	388	388	Natural variant	ID=VAR_036377;Note=In a colorectal cancer sample%3B somatic mutation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ACSL5	Q9ULC5	361	406	388	388	Natural variant	ID=VAR_036377;Note=In a colorectal cancer sample%3B somatic mutation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SCIN	Q9Y6U3	222	253	1	715	Chain	ID=PRO_0000218744;Note=Adseverin
SCIN	Q9Y6U3	222	253	1	363	Region	Note=Actin-severing;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCIN	Q9Y6U3	222	253	1	247	Alternative sequence	ID=VSP_040548;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCIN	Q9Y6U3	222	253	218	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1K
SCIN	Q9Y6U3	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A1M
ADCY10	Q96PN6	1494	1557	1	1610	Chain	ID=PRO_0000317101;Note=Adenylate cyclase type 10
ADCY10	Q96PN6	97	145	1	1610	Chain	ID=PRO_0000317101;Note=Adenylate cyclase type 10
ADCY10	Q96PN6	49	84	1	1610	Chain	ID=PRO_0000317101;Note=Adenylate cyclase type 10
ADCY10	Q96PN6	97	145	42	179	Domain	Note=Guanylate cyclase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00099
ADCY10	Q96PN6	49	84	42	179	Domain	Note=Guanylate cyclase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00099
ADCY10	Q96PN6	49	84	47	52	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4USW,ECO:0000269|PubMed:25040695,ECO:0000305|PubMed:24567411,ECO:0000305|PubMed:24616449;Dbxref=PMID:25040695,PMID:24567411,PMID:24616449
ADCY10	Q96PN6	97	145	99	99	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000305,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00099,ECO:0000269|PubMed:25040695,ECO:0000305|PubMed:24567411,ECO:0000305|PubMed:24616449;Dbxref=PMID:25040695,PMID:24567411,PMID:24616449
ADCY10	Q96PN6	97	145	99	99	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00099
ADCY10	Q96PN6	97	145	99	99	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4USW,ECO:0000269|PubMed:25040695,ECO:0000305|PubMed:24567411,ECO:0000305|PubMed:24616449;Dbxref=PMID:25040695,PMID:24567411,PMID:24616449
ADCY10	Q96PN6	97	145	144	144	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4USW,ECO:0000269|PubMed:25040695,ECO:0000305|PubMed:24567411,ECO:0000305|PubMed:24616449;Dbxref=PMID:25040695,PMID:24567411,PMID:24616449
ADCY10	Q96PN6	97	145	1	1099	Alternative sequence	ID=VSP_030866;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
ADCY10	Q96PN6	49	84	1	1099	Alternative sequence	ID=VSP_030866;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
ADCY10	Q96PN6	97	145	1	153	Alternative sequence	ID=VSP_046329;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADCY10	Q96PN6	49	84	1	153	Alternative sequence	ID=VSP_046329;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADCY10	Q96PN6	97	145	1	97	Alternative sequence	ID=VSP_030867;Note=In isoform 2. MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFA->MSLSE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11932268;Dbxref=PMID:11932268
ADCY10	Q96PN6	49	84	1	97	Alternative sequence	ID=VSP_030867;Note=In isoform 2. MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFA->MSLSE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11932268;Dbxref=PMID:11932268
ADCY10	Q96PN6	1494	1557	1472	1610	Alternative sequence	ID=VSP_030870;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
ADCY10	Q96PN6	49	84	49	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	49	84	55	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	49	84	61	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	49	84	67	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	97	145	98	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	97	145	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	97	145	112	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
ADCY10	Q96PN6	97	145	130	132	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OYB
ADCY10	Q96PN6	97	145	135	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OYB
ADCY10	Q96PN6	97	145	144	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CLF
AES	Q08117	99	124	1	197	Chain	ID=PRO_0000050834;Note=Amino-terminal enhancer of split
AES	Q08117	63	78	1	197	Chain	ID=PRO_0000050834;Note=Amino-terminal enhancer of split
AES	Q08117	99	124	1	131	Compositional bias	Note=Gln-rich (Q domain)
AES	Q08117	63	78	1	131	Compositional bias	Note=Gln-rich (Q domain)
AGGF1	Q8N302	227	290	2	714	Chain	ID=PRO_0000064495;Note=Angiogenic factor with G patch and FHA domains 1
AGGF1	Q8N302	455	489	2	714	Chain	ID=PRO_0000064495;Note=Angiogenic factor with G patch and FHA domains 1
AGGF1	Q8N302	455	489	434	487	Domain	Note=FHA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00086
AGGF1	Q8N302	227	290	110	714	Alternative sequence	ID=VSP_009632;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGGF1	Q8N302	455	489	110	714	Alternative sequence	ID=VSP_009632;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGGF1	Q8N302	227	290	177	714	Alternative sequence	ID=VSP_009634;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
AGGF1	Q8N302	455	489	177	714	Alternative sequence	ID=VSP_009634;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
AGGF1	Q8N302	455	489	471	471	Natural variant	ID=VAR_037447;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856835,PMID:15489334
AGXT2	Q9BYV1	396	446	42	514	Chain	ID=PRO_0000001269;Note=Alanine--glyoxylate aminotransferase 2%2C mitochondrial
AGXT2	Q9BYV1	396	446	417	417	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UEG6
AGXT2	Q9BYV1	396	446	417	417	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UEG6
AGXT2	Q9BYV1	396	446	420	420	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UEG6
AGXT2	Q9BYV1	396	446	420	420	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UEG6
AKAP11	Q9UKA4	17	56	1	1901	Chain	ID=PRO_0000064517;Note=A-kinase anchor protein 11
AKAP11	Q9UKA4	72	117	1	1901	Chain	ID=PRO_0000064517;Note=A-kinase anchor protein 11
AKAP11	Q9UKA4	1758	1785	1	1901	Chain	ID=PRO_0000064517;Note=A-kinase anchor protein 11
AKAP11	Q9UKA4	1758	1785	1705	1767	Compositional bias	Note=Ser-rich
AKAP11	Q9UKA4	17	56	18	18	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163
AKAP8L	Q9ULX6	29	40	1	646	Chain	ID=PRO_0000075384;Note=A-kinase anchor protein 8-like
AKAP8L	Q9ULX6	29	40	1	268	Region	Note=Sufficient for activation of CTE-mediated expression;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11402034;Dbxref=PMID:11402034
AKAP3	O75969	32	802	1	853	Chain	ID=PRO_0000064526;Note=A-kinase anchor protein 3
AKAP3	O75969	32	802	1	853	Chain	ID=PRO_0000064526;Note=A-kinase anchor protein 3
AKAP3	O75969	32	802	124	137	Region	Note=PKA-RII subunit binding domain
AKAP3	O75969	32	802	124	137	Region	Note=PKA-RII subunit binding domain
AKAP3	O75969	32	802	205	205	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	205	205	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	208	208	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	208	208	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	403	403	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	403	403	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	404	404	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	404	404	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	635	635	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	635	635	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	636	636	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	636	636	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:12509440;Dbxref=PMID:12509440
AKAP3	O75969	32	802	118	118	Natural variant	ID=VAR_055488;Note=G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10334916,ECO:0000269|PubMed:10529264,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2072355,PMID:10334916,PMID:10529264,PMID:14702039,PMID:15489334
AKAP3	O75969	32	802	118	118	Natural variant	ID=VAR_055488;Note=G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10334916,ECO:0000269|PubMed:10529264,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2072355,PMID:10334916,PMID:10529264,PMID:14702039,PMID:15489334
AKAP3	O75969	32	802	464	464	Natural variant	ID=VAR_060730;Note=T->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10319321,ECO:0000269|PubMed:10334916,ECO:0000269|PubMed:10529264;Dbxref=dbSNP:rs11063266,PMID:10319321,PMID:10334916,PMID:10529264
AKAP3	O75969	32	802	464	464	Natural variant	ID=VAR_060730;Note=T->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10319321,ECO:0000269|PubMed:10334916,ECO:0000269|PubMed:10529264;Dbxref=dbSNP:rs11063266,PMID:10319321,PMID:10334916,PMID:10529264
AKAP3	O75969	32	802	500	500	Natural variant	ID=VAR_055489;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10529264;Dbxref=dbSNP:rs12366671,PMID:10529264
AKAP3	O75969	32	802	500	500	Natural variant	ID=VAR_055489;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10529264;Dbxref=dbSNP:rs12366671,PMID:10529264
AKAP3	O75969	32	802	525	525	Natural variant	ID=VAR_061000;Note=E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10319321,ECO:0000269|PubMed:10334916,ECO:0000269|PubMed:10529264;Dbxref=dbSNP:rs1990312,PMID:10319321,PMID:10334916,PMID:10529264
AKAP3	O75969	32	802	525	525	Natural variant	ID=VAR_061000;Note=E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10319321,ECO:0000269|PubMed:10334916,ECO:0000269|PubMed:10529264;Dbxref=dbSNP:rs1990312,PMID:10319321,PMID:10334916,PMID:10529264
AKAP3	O75969	32	802	661	661	Natural variant	ID=VAR_055490;Note=I->T;Dbxref=dbSNP:rs1990313
AKAP3	O75969	32	802	661	661	Natural variant	ID=VAR_055490;Note=I->T;Dbxref=dbSNP:rs1990313
AKAP3	O75969	32	802	700	700	Natural variant	ID=VAR_055491;Note=S->F;Dbxref=dbSNP:rs2041291
AKAP3	O75969	32	802	700	700	Natural variant	ID=VAR_055491;Note=S->F;Dbxref=dbSNP:rs2041291
AKAP3	O75969	32	802	700	700	Natural variant	ID=VAR_059112;Note=S->P;Dbxref=dbSNP:rs2041290
AKAP3	O75969	32	802	700	700	Natural variant	ID=VAR_059112;Note=S->P;Dbxref=dbSNP:rs2041290
AKAP3	O75969	32	802	725	725	Natural variant	ID=VAR_055492;Note=S->L;Dbxref=dbSNP:rs2072357
AKAP3	O75969	32	802	725	725	Natural variant	ID=VAR_055492;Note=S->L;Dbxref=dbSNP:rs2072357
AKAP3	O75969	32	802	131	131	Mutagenesis	Note=Abolishes interaction with ROPN1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278869;Dbxref=PMID:11278869
AKAP3	O75969	32	802	131	131	Mutagenesis	Note=Abolishes interaction with ROPN1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278869;Dbxref=PMID:11278869
AKAP3	O75969	32	802	272	272	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	272	272	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	282	282	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	282	282	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	402	402	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	402	402	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	467	467	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	467	467	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	597	597	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	597	597	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	700	700	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP3	O75969	32	802	700	700	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GPT	P24298	377	429	2	496	Chain	ID=PRO_0000123933;Note=Alanine aminotransferase 1
GPT	P24298	377	429	2	496	Chain	ID=PRO_0000123933;Note=Alanine aminotransferase 1
CHRNA7	P36544	264	293	23	502	Chain	ID=PRO_0000000366;Note=Neuronal acetylcholine receptor subunit alpha-7
CHRNA7	P36544	264	293	262	280	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHRNA7	P36544	264	293	103	502	Alternative sequence	ID=VSP_058108;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHRNA7	P36544	264	293	260	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MAW
CHRNA7	P36544	264	293	286	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MAW
CHRNA7	P36544	264	293	293	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MAW
NDUFAB1	O14561	56	97	1	68	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:19892738;Dbxref=PMID:25944712,PMID:19892738
NDUFAB1	O14561	56	97	69	156	Chain	ID=PRO_0000000561;Note=Acyl carrier protein%2C mitochondrial
NDUFAB1	O14561	56	97	77	152	Domain	Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258
NDUFAB1	O14561	56	97	88	88	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CR21
NDUFAB1	O14561	56	97	76	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
NDUFAB1	O14561	56	97	91	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
NDUFAB1	O14561	56	97	95	97	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
ACRBP	Q8NEB7	419	475	26	543	Chain	ID=PRO_0000227516;Note=Acrosin-binding protein
ACSF2	Q96CM8	108	151	42	615	Chain	ID=PRO_0000315793;Note=Acyl-CoA synthetase family member 2%2C mitochondrial
ACSF2	Q96CM8	151	169	42	615	Chain	ID=PRO_0000315793;Note=Acyl-CoA synthetase family member 2%2C mitochondrial
ACSF2	Q96CM8	264	296	42	615	Chain	ID=PRO_0000315793;Note=Acyl-CoA synthetase family member 2%2C mitochondrial
ACSF2	Q96CM8	539	576	42	615	Chain	ID=PRO_0000315793;Note=Acyl-CoA synthetase family member 2%2C mitochondrial
ACSF2	Q96CM8	576	599	42	615	Chain	ID=PRO_0000315793;Note=Acyl-CoA synthetase family member 2%2C mitochondrial
ACSF2	Q96CM8	264	296	263	271	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSF2	Q96CM8	576	599	599	599	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSF2	Q96CM8	539	576	544	544	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCW8
ACSF2	Q96CM8	539	576	544	544	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCW8
ACSF2	Q96CM8	539	576	570	570	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCW8
ACSF2	Q96CM8	539	576	570	570	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCW8
ACSF2	Q96CM8	576	599	599	599	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCW8
ACSF2	Q96CM8	108	151	1	160	Alternative sequence	ID=VSP_055803;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACSF2	Q96CM8	151	169	1	160	Alternative sequence	ID=VSP_055803;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACSF2	Q96CM8	108	151	146	158	Alternative sequence	ID=VSP_055805;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACSF2	Q96CM8	151	169	146	158	Alternative sequence	ID=VSP_055805;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAD2	Q8NCV1	186	202	1	583	Chain	ID=PRO_0000309524;Note=Adenosine deaminase domain-containing protein 2
AFAP1L2	Q8N4X5	514	596	1	818	Chain	ID=PRO_0000050805;Note=Actin filament-associated protein 1-like 2
AFAP1L2	Q8N4X5	322	357	1	818	Chain	ID=PRO_0000050805;Note=Actin filament-associated protein 1-like 2
AFAP1L2	Q8N4X5	322	357	353	447	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AFAP1L2	Q8N4X5	322	357	1	478	Alternative sequence	ID=VSP_014254;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11572484;Dbxref=PMID:11572484
AFAP1L2	Q8N4X5	514	596	522	522	Natural variant	ID=VAR_050507;Note=T->S;Dbxref=dbSNP:rs2781806
AFAP1L2	Q8N4X5	514	596	567	567	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1L2	Q8N4X5	514	596	596	596	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFF4	Q9UHB7	463	769	1	1163	Chain	ID=PRO_0000239393;Note=AF4/FMR2 family member 4
AFF4	Q9UHB7	321	350	1	1163	Chain	ID=PRO_0000239393;Note=AF4/FMR2 family member 4
AFF4	Q9UHB7	321	350	102	461	Compositional bias	Note=Ser-rich
AFF4	Q9UHB7	321	350	350	351	Site	Note=Breakpoint for insertion to form KMT2A/MLL1-AFF4 fusion protein
AFF4	Q9UHB7	463	769	487	487	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
AFF4	Q9UHB7	463	769	490	490	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ESC8
AFF4	Q9UHB7	463	769	491	491	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ESC8
AFF4	Q9UHB7	463	769	549	549	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
AFF4	Q9UHB7	463	769	671	671	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19369195;Dbxref=PMID:18669648,PMID:19369195
AFF4	Q9UHB7	463	769	674	674	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:23186163;Dbxref=PMID:18220336,PMID:23186163
AFF4	Q9UHB7	463	769	680	680	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
AFF4	Q9UHB7	463	769	694	694	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
AFF4	Q9UHB7	463	769	703	703	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
AFF4	Q9UHB7	463	769	706	706	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163,PMID:24275569
AFF4	Q9UHB7	463	769	712	712	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
AFF4	Q9UHB7	463	769	583	583	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
AFF4	Q9UHB7	463	769	354	1163	Alternative sequence	ID=VSP_019219;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AFF4	Q9UHB7	463	769	757	757	Natural variant	ID=VAR_064693;Note=Found in a clear cell renal carcinoma case%3B somatic mutation. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752
AFF4	Q9UHB7	321	350	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JW9
GLA	P06280	267	333	32	429	Chain	ID=PRO_0000001004;Note=Alpha-galactosidase A
GLA	P06280	267	333	267	267	Natural variant	ID=VAR_012419;Note=In FD. M->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10666480,ECO:0000269|PubMed:11668641;Dbxref=dbSNP:rs730880451,PMID:10666480,PMID:11668641
GLA	P06280	267	333	269	269	Natural variant	ID=VAR_000473;Note=In FD. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8395937;Dbxref=dbSNP:rs28935488,PMID:8395937
GLA	P06280	267	333	269	269	Natural variant	ID=VAR_077404;Note=In FD%3B loss of enzyme activity. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs28935488,PMID:26415523
GLA	P06280	267	333	272	272	Natural variant	ID=VAR_000474;Note=In FD. N->K
GLA	P06280	267	333	272	272	Natural variant	ID=VAR_032292;Note=In FD. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15162124;Dbxref=dbSNP:rs28935495,PMID:15162124
GLA	P06280	267	333	276	276	Natural variant	ID=VAR_062563;Note=In FD%3B loss of enzyme activity. S->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15712228,ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312432,PMID:15712228,PMID:26415523
GLA	P06280	267	333	279	279	Natural variant	ID=VAR_000475;Note=In FD%3B mild%3B does not significantly affect the enzyme activity but the mutant protein levels are decreased presumably in the ER of the cells. Q->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10838196,ECO:0000269|PubMed:1315715,ECO:0000269|PubMed:7575533,ECO:0000269|PubMed:9105656;Dbxref=dbSNP:rs28935485,PMID:10838196,PMID:1315715,PMID:7575533,PMID:9105656
GLA	P06280	267	333	279	279	Natural variant	ID=VAR_012420;Note=In FD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11668641;Dbxref=PMID:11668641
GLA	P06280	267	333	280	280	Natural variant	ID=VAR_012421;Note=In FD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11668641;Dbxref=PMID:11668641
GLA	P06280	267	333	284	284	Natural variant	ID=VAR_000476;Note=In FD. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8807334;Dbxref=PMID:8807334
GLA	P06280	267	333	285	285	Natural variant	ID=VAR_062564;Note=In FD. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712228;Dbxref=PMID:15712228
GLA	P06280	267	333	287	287	Natural variant	ID=VAR_012422;Note=In FD. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9100224;Dbxref=PMID:9100224
GLA	P06280	267	333	287	287	Natural variant	ID=VAR_012423;Note=In FD. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8875188;Dbxref=PMID:8875188
GLA	P06280	267	333	288	288	Natural variant	ID=VAR_000477;Note=In FD. A->D;Dbxref=dbSNP:rs869312437
GLA	P06280	267	333	289	289	Natural variant	ID=VAR_012424;Note=In FD. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666480;Dbxref=dbSNP:rs140329381,PMID:10666480
GLA	P06280	267	333	289	289	Natural variant	ID=VAR_077405;Note=Polymorphism%3B decreased enzyme activity. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs140329381,PMID:26415523
GLA	P06280	267	333	296	296	Natural variant	ID=VAR_012425;Note=In FD%3B atypical. M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7575533,ECO:0000269|PubMed:7596372,ECO:0000269|PubMed:9105656;Dbxref=dbSNP:rs104894846,PMID:7575533,PMID:7596372,PMID:9105656
GLA	P06280	267	333	296	296	Natural variant	ID=VAR_000478;Note=In FD%3B mild. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1846223;Dbxref=dbSNP:rs104894830,PMID:1846223
GLA	P06280	267	333	297	297	Natural variant	ID=VAR_000479;Note=In FD. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7504405;Dbxref=dbSNP:rs28935489,PMID:7504405
GLA	P06280	267	333	298	298	Natural variant	ID=VAR_012426;Note=In FD. N->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11668641,ECO:0000269|PubMed:8875188;Dbxref=PMID:11668641,PMID:8875188
GLA	P06280	267	333	298	298	Natural variant	ID=VAR_000480;Note=In FD. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8807334;Dbxref=PMID:8807334
GLA	P06280	267	333	298	298	Natural variant	ID=VAR_012427;Note=In FD. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9100224;Dbxref=PMID:9100224
GLA	P06280	267	333	300	300	Natural variant	ID=VAR_062565;Note=In FD. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712228;Dbxref=PMID:15712228
GLA	P06280	267	333	301	301	Natural variant	ID=VAR_000481;Note=In FD%3B mild%3B does not significantly affect the enzyme activity but the mutant protein levels are decreased presumably in the ER of the cells. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10208848,ECO:0000269|PubMed:10838196,ECO:0000269|PubMed:10916280,ECO:0000269|PubMed:1315715,ECO:0000269|PubMed:2171331,ECO:0000269|PubMed:7575533,ECO:0000269|PubMed:7599642,ECO:0000269|PubMed:8738659,ECO:0000269|PubMed:9105656;Dbxref=dbSNP:rs104894828,PMID:10208848,PMID:10838196,PMID:10916280,PMID:1315715,PMID:2171331,PMID:7575533,PMID:7599642,PMID:8738659,PMID:9105656
GLA	P06280	267	333	309	309	Natural variant	ID=VAR_077406;Note=In FD%3B unknown pathological significance%3B decreased enzyme activity. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312155,PMID:26415523
GLA	P06280	267	333	313	313	Natural variant	ID=VAR_077407;Note=Polymorphism%3B does not affect enzyme activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs28935490,PMID:26415523
GLA	P06280	267	333	313	313	Natural variant	ID=VAR_000482;Note=In FD. D->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11668641,ECO:0000269|PubMed:7504405,ECO:0000269|PubMed:9452111;Dbxref=dbSNP:rs28935490,PMID:11668641,PMID:7504405,PMID:9452111
GLA	P06280	267	333	315	315	Natural variant	ID=VAR_077408;Note=In FD%3B unknown pathological significance%3B decreased enzyme activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312156,PMID:26415523
GLA	P06280	267	333	316	322	Natural variant	ID=VAR_012429;Note=In FD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8931708;Dbxref=PMID:8931708
GLA	P06280	267	333	316	316	Natural variant	ID=VAR_077409;Note=In FD%3B unknown pathological significance%3B decreased enzyme activity. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312157,PMID:26415523
GLA	P06280	267	333	316	316	Natural variant	ID=VAR_000483;Note=In FD. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8069316;Dbxref=PMID:8069316
GLA	P06280	267	333	317	317	Natural variant	ID=VAR_077410;Note=In FD%3B loss of enzyme activity. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312158,PMID:26415523
GLA	P06280	267	333	320	320	Natural variant	ID=VAR_012430;Note=In FD. N->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7575533,ECO:0000269|PubMed:9105656;Dbxref=PMID:7575533,PMID:9105656
GLA	P06280	267	333	320	320	Natural variant	ID=VAR_012431;Note=In FD%3B loss of enzyme activity. N->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10916280,ECO:0000269|PubMed:26415523;Dbxref=PMID:10916280,PMID:26415523
GLA	P06280	267	333	321	321	Natural variant	ID=VAR_012432;Note=In FD. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666480;Dbxref=dbSNP:rs730880439,PMID:10666480
GLA	P06280	267	333	323	323	Natural variant	ID=VAR_077411;Note=In FD%3B unknown pathological significance%3B decreased enzyme activity. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312159,PMID:26415523
GLA	P06280	267	333	327	327	Natural variant	ID=VAR_000484;Note=In FD. Q->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10208848,ECO:0000269|PubMed:8395937;Dbxref=dbSNP:rs28935491,PMID:10208848,PMID:8395937
GLA	P06280	267	333	327	327	Natural variant	ID=VAR_077412;Note=In FD%3B loss of enzyme activity. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312160,PMID:26415523
GLA	P06280	267	333	327	327	Natural variant	ID=VAR_077413;Note=In FD%3B loss of enzyme activity. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312160,PMID:26415523
GLA	P06280	267	333	328	328	Natural variant	ID=VAR_000486;Note=In FD. G->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15712228,ECO:0000269|PubMed:7504405;Dbxref=dbSNP:rs28935492,PMID:15712228,PMID:7504405
GLA	P06280	267	333	328	328	Natural variant	ID=VAR_000485;Note=In FD%3B loss of enzyme activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1315715,ECO:0000269|PubMed:26415523,ECO:0000269|PubMed:7575533,ECO:0000269|PubMed:9105656;Dbxref=dbSNP:rs104894832,PMID:1315715,PMID:26415523,PMID:7575533,PMID:9105656
GLA	P06280	267	333	328	328	Natural variant	ID=VAR_062566;Note=In FD. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712228;Dbxref=PMID:15712228
GLA	P06280	267	333	330	330	Natural variant	ID=VAR_077414;Note=In FD%3B unknown pathological significance%3B decreased enzyme activity. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26415523;Dbxref=dbSNP:rs869312161,PMID:26415523
GLA	P06280	267	333	272	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HG3
GLA	P06280	267	333	277	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HG3
GLA	P06280	267	333	294	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HG3
GLA	P06280	267	333	305	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HG3
GLA	P06280	267	333	314	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HG3
GLA	P06280	267	333	329	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HG3
AFG3L2	Q9Y4W6	660	725	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	593	660	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	517	554	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	475	517	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	342	388	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	184	209	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	71	97	67	797	Chain	ID=PRO_0000442312;Note=AFG3-like protein 2
AFG3L2	Q9Y4W6	342	388	348	355	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
AFG3L2	Q9Y4W6	593	660	649	649	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WZ49
AFG3L2	Q9Y4W6	593	660	616	616	Natural variant	ID=VAR_067330;Note=In SPAX5%3B hypomorphic mutation%3B results in impaired oligomerization with itself and SPG7%3B retains ATPase and proteolytic activities. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22022284;Dbxref=dbSNP:rs387906889,PMID:22022284
AFG3L2	Q9Y4W6	593	660	621	621	Natural variant	ID=VAR_080736;Note=In SCA28%3B unknown pathological significance. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29053796;Dbxref=PMID:29053796
AFG3L2	Q9Y4W6	593	660	654	654	Natural variant	ID=VAR_064402;Note=In SCA28. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20725928;Dbxref=dbSNP:rs151344513,PMID:20725928
AFG3L2	Q9Y4W6	660	725	666	666	Natural variant	ID=VAR_064403;Note=In SCA28. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20725928;Dbxref=dbSNP:rs151344515,PMID:20725928
AFG3L2	Q9Y4W6	660	725	666	666	Natural variant	ID=VAR_064404;Note=In SCA28. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20725928;Dbxref=dbSNP:rs151344515,PMID:20725928
AFG3L2	Q9Y4W6	660	725	666	666	Natural variant	ID=VAR_064405;Note=In SCA28. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20725928,ECO:0000269|PubMed:29053796;Dbxref=dbSNP:rs151344514,PMID:20725928,PMID:29053796
AFG3L2	Q9Y4W6	660	725	671	671	Natural variant	ID=VAR_064406;Note=In SCA28. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20725928;Dbxref=dbSNP:rs151344518,PMID:20725928
AFG3L2	Q9Y4W6	660	725	671	671	Natural variant	ID=VAR_064407;Note=In SCA28. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20725928;Dbxref=dbSNP:rs151344517,PMID:20725928
AFG3L2	Q9Y4W6	660	725	689	689	Natural variant	ID=VAR_075198;Note=In SCA28. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24293060;Dbxref=PMID:24293060
AFG3L2	Q9Y4W6	660	725	689	689	Natural variant	ID=VAR_075199;Note=In SCA28. Y->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26677414;Dbxref=PMID:26677414
AFG3L2	Q9Y4W6	660	725	691	691	Natural variant	ID=VAR_063545;Note=In SCA28. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20208537;Dbxref=dbSNP:rs151344520,PMID:20208537
AFG3L2	Q9Y4W6	660	725	694	694	Natural variant	ID=VAR_063546;Note=In SCA28. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20208537;Dbxref=dbSNP:rs151344521,PMID:20208537
AFG3L2	Q9Y4W6	660	725	700	700	Natural variant	ID=VAR_064408;Note=In SCA28. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20354562;Dbxref=dbSNP:rs151344522,PMID:20354562
AFG3L2	Q9Y4W6	660	725	702	702	Natural variant	ID=VAR_063547;Note=In SCA28. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20208537;Dbxref=dbSNP:rs151344523,PMID:20208537
AFG3L2	Q9Y4W6	71	97	74	74	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFG3L2	Q9Y4W6	593	660	633	633	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFG3L2	Q9Y4W6	184	209	185	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNA
AFG3L2	Q9Y4W6	184	209	192	194	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNA
AFG3L2	Q9Y4W6	184	209	195	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNA
AFG3L2	Q9Y4W6	184	209	202	204	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNA
AGFG2	O95081	362	390	1	481	Chain	ID=PRO_0000204828;Note=Arf-GAP domain and FG repeat-containing protein 2
AGFG2	O95081	362	390	367	427	Compositional bias	Note=Pro-rich
AGFG2	O95081	362	390	157	481	Alternative sequence	ID=VSP_010668;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGFG2	O95081	362	390	365	365	Natural variant	ID=VAR_050566;Note=T->N;Dbxref=dbSNP:rs34731997
CHRNA1	P02708	359	439	21	482	Chain	ID=PRO_0000000305;Note=Acetylcholine receptor subunit alpha
CHRNA1	P02708	78	103	21	482	Chain	ID=PRO_0000000305;Note=Acetylcholine receptor subunit alpha
CHRNA1	P02708	78	103	21	255	Topological domain	Note=Extracellular
CHRNA1	P02708	359	439	342	453	Topological domain	Note=Cytoplasmic
CHRNA1	P02708	78	103	79	103	Alternative sequence	ID=VSP_000071;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:3338555,ECO:0000303|PubMed:7725386;Dbxref=PMID:3338555,PMID:7725386
CHRNA1	P02708	359	439	383	383	Natural variant	ID=VAR_038600;Note=D->V;Dbxref=dbSNP:rs6739001
CHRNA1	P02708	359	439	415	415	Sequence conflict	Note=P->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHRNA1	P02708	78	103	69	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HBT
ACVRL1	P37023	349	415	22	503	Chain	ID=PRO_0000024420;Note=Serine/threonine-protein kinase receptor R3
ACVRL1	P37023	349	415	142	503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVRL1	P37023	349	415	202	492	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVRL1	P37023	349	415	374	374	Natural variant	ID=VAR_026800;Note=In HHT2%3B retained in the endoplasmic reticulum. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14684682,ECO:0000269|PubMed:15024723;Dbxref=dbSNP:rs1060503248,PMID:14684682,PMID:15024723
ACVRL1	P37023	349	415	374	374	Natural variant	ID=VAR_006211;Note=In HHT2. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11170071,ECO:0000269|PubMed:14684682,ECO:0000269|PubMed:15712270,ECO:0000269|PubMed:9245985;Dbxref=dbSNP:rs28936401,PMID:11170071,PMID:14684682,PMID:15712270,PMID:9245985
ACVRL1	P37023	349	415	376	376	Natural variant	ID=VAR_006212;Note=In HHT2. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8640225;Dbxref=dbSNP:rs28936399,PMID:8640225
ACVRL1	P37023	349	415	376	376	Natural variant	ID=VAR_026801;Note=In HHT2. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15024723;Dbxref=PMID:15024723
ACVRL1	P37023	349	415	378	378	Natural variant	ID=VAR_026802;Note=In HHT2%3B retained in the endoplasmic reticulum. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14684682;Dbxref=PMID:14684682
ACVRL1	P37023	349	415	378	378	Natural variant	ID=VAR_070335;Note=In HHT2%3B loss of receptor activity in response to BMP9%3B retained in the endoplasmic reticulum. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20414677,ECO:0000269|PubMed:26176610;Dbxref=dbSNP:rs959973779,PMID:20414677,PMID:26176610
ACVRL1	P37023	349	415	379	379	Natural variant	ID=VAR_075241;Note=In HHT2%3B loss of receptor activity in response to BMP9%3B retained in the endoplasmic reticulum. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26176610;Dbxref=PMID:26176610
ACVRL1	P37023	349	415	379	379	Natural variant	ID=VAR_026803;Note=In HHT2%3B loss of receptor activity in response to BMP9%3B retained in the endoplasmic reticulum. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15024723,ECO:0000269|PubMed:15712270,ECO:0000269|PubMed:26176610;Dbxref=dbSNP:rs1131691686,PMID:15024723,PMID:15712270,PMID:26176610
ACVRL1	P37023	349	415	396	396	Natural variant	ID=VAR_079587;Note=Found in patients with pulmonary arterial hypertension%3B unknown pathological significance. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24936649;Dbxref=PMID:24936649
ACVRL1	P37023	349	415	397	397	Natural variant	ID=VAR_026804;Note=In HHT2. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15024723;Dbxref=PMID:15024723
ACVRL1	P37023	349	415	398	398	Natural variant	ID=VAR_026805;Note=In HHT2. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11170071;Dbxref=dbSNP:rs121909286,PMID:11170071
ACVRL1	P37023	349	415	399	399	Natural variant	ID=VAR_026806;Note=In HHT2. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14684682;Dbxref=dbSNP:rs121909289,PMID:14684682
ACVRL1	P37023	349	415	400	400	Natural variant	ID=VAR_070336;Note=Found in a patient with hereditary hemorrhagic talagiectasia%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20414677;Dbxref=PMID:20414677
ACVRL1	P37023	349	415	403	403	Natural variant	ID=VAR_070337;Note=In HHT2. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16525724;Dbxref=PMID:16525724
ACVRL1	P37023	349	415	404	404	Natural variant	ID=VAR_075242;Note=In HHT2%3B loss of receptor activity in response to BMP9%3B predominantly retained in the endoplasmic reticulum. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26176610;Dbxref=PMID:26176610
ACVRL1	P37023	349	415	407	407	Natural variant	ID=VAR_026807;Note=In HHT2. E->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10767348,ECO:0000269|PubMed:15712270;Dbxref=PMID:10767348,PMID:15712270
ACVRL1	P37023	349	415	411	411	Natural variant	ID=VAR_026808;Note=In HHT2. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15024723;Dbxref=dbSNP:rs121909284,PMID:15024723
ACVRL1	P37023	349	415	411	411	Natural variant	ID=VAR_006213;Note=In HHT2%3B retained in the endoplasmic reticulum. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14684682,ECO:0000269|PubMed:15024723,ECO:0000269|PubMed:8640225;Dbxref=dbSNP:rs121909284,PMID:14684682,PMID:15024723,PMID:8640225
ACVRL1	P37023	349	415	411	411	Natural variant	ID=VAR_026809;Note=In HHT2%3B loss of receptor activity in response to BMP9%3B predominantly retained in the endoplasmic reticulum. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11484689,ECO:0000269|PubMed:15024723,ECO:0000269|PubMed:15712270,ECO:0000269|PubMed:26176610;Dbxref=dbSNP:rs121909287,PMID:11484689,PMID:15024723,PMID:15712270,PMID:26176610
ACVRL1	P37023	349	415	353	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MY0
ACVRL1	P37023	349	415	357	359	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MY0
ACVRL1	P37023	349	415	373	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MY0
ACVRL1	P37023	349	415	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MY0
ACVRL1	P37023	349	415	390	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MY0
ADAD1	Q96M93	176	199	1	576	Chain	ID=PRO_0000309520;Note=Adenosine deaminase domain-containing protein 1
ADAD1	Q96M93	176	199	198	198	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1L1	Q8TED9	145	178	1	768	Chain	ID=PRO_0000295239;Note=Actin filament-associated protein 1-like 1
AFAP1L1	Q8TED9	718	761	1	768	Chain	ID=PRO_0000295239;Note=Actin filament-associated protein 1-like 1
AFAP1L1	Q8TED9	145	178	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BZI0
AFAP1L1	Q8TED9	718	761	747	747	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BZI0
AFAP1L1	Q8TED9	145	178	1	385	Alternative sequence	ID=VSP_026856;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AFAP1L1	Q8TED9	718	761	378	768	Alternative sequence	ID=VSP_026858;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AFAP1L1	Q8TED9	718	761	719	761	Alternative sequence	ID=VSP_026859;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AHSA1	O95433	187	230	1	338	Chain	ID=PRO_0000215820;Note=Activator of 90 kDa heat shock protein ATPase homolog 1
AHSA1	O95433	230	264	1	338	Chain	ID=PRO_0000215820;Note=Activator of 90 kDa heat shock protein ATPase homolog 1
AHSA1	O95433	187	230	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
AHSA1	O95433	187	230	212	212	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
AHSA1	O95433	187	230	223	223	Modified residue	Note=Phosphotyrosine%3B by ABL;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29127155;Dbxref=PMID:29127155
AHSA1	O95433	230	264	258	258	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
AHSA1	O95433	187	230	203	203	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
AHSA1	O95433	187	230	223	223	Mutagenesis	Note=Phosphomimetic mutant. Increases the binding to HSP90AA1 resulting in TSC1 dissociation from HSP90AA1. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29127155;Dbxref=PMID:29127155
AHSA1	O95433	187	230	206	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X53
AHSA1	O95433	187	230	219	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X53
AHSA1	O95433	187	230	229	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X53
AHSA1	O95433	230	264	229	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X53
AHSA1	O95433	230	264	253	256	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X53
AHSA1	O95433	230	264	261	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X53
AIRE	O43918	266	293	1	545	Chain	ID=PRO_0000064513;Note=Autoimmune regulator
AIRE	O43918	365	426	1	545	Chain	ID=PRO_0000064513;Note=Autoimmune regulator
AIRE	O43918	266	293	181	280	Domain	Note=SAND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00185
AIRE	O43918	365	426	414	418	Motif	Note=LXXLL motif 3
AIRE	O43918	266	293	1	292	Alternative sequence	ID=VSP_004089;Note=In isoform 2%2C isoform 3 and isoform 4. MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLH->MWLVYSSGAPGTQQPARNRVFFPIGMAPGGVCWRPDGWGTGGQGRISGPGSMGAGQRLGSSGTQRCCWGSCFGKEVALRRVLHPS;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9398839;Dbxref=PMID:15489334,PMID:9398839
AIRE	O43918	266	293	293	293	Alternative sequence	ID=VSP_043529;Note=In isoform 4. Q->PVCMGVSCLCQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AIRE	O43918	365	426	377	545	Alternative sequence	ID=VSP_004090;Note=In isoform 3. VRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS->PRCQGWTPRPCTPYCVWVLRVSRTWLLVRVAGCAEMVRTCCGVLTAPLPSTGAATSQPAPPGPGRACAADPAQET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9398839;Dbxref=PMID:9398839
AIRE	O43918	266	293	278	278	Natural variant	ID=VAR_005006;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11524731,ECO:0000269|PubMed:12625412,ECO:0000269|PubMed:9717837;Dbxref=dbSNP:rs1800520,PMID:11524731,PMID:12625412,PMID:9717837
AIRE	O43918	365	426	423	426	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LRI
ALDH1A1	P00352	453	477	2	501	Chain	ID=PRO_0000056415;Note=Retinal dehydrogenase 1
ALDH1A1	P00352	345	400	2	501	Chain	ID=PRO_0000056415;Note=Retinal dehydrogenase 1
ALDH1A1	P00352	211	249	2	501	Chain	ID=PRO_0000056415;Note=Retinal dehydrogenase 1
ALDH1A1	P00352	168	211	2	501	Chain	ID=PRO_0000056415;Note=Retinal dehydrogenase 1
ALDH1A1	P00352	168	211	167	170	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4WB9,ECO:0000244|PDB:4X4L
ALDH1A1	P00352	168	211	193	196	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4WB9,ECO:0000244|PDB:4X4L
ALDH1A1	P00352	211	249	226	227	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4WB9,ECO:0000244|PDB:4X4L
ALDH1A1	P00352	211	249	246	247	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4WB9,ECO:0000244|PDB:4X4L
ALDH1A1	P00352	345	400	349	353	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4WB9,ECO:0000244|PDB:4X4L
ALDH1A1	P00352	345	400	400	402	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4WB9,ECO:0000244|PDB:4X4L
ALDH1A1	P00352	168	211	170	170	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20000
ALDH1A1	P00352	345	400	353	353	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ALDH1A1	P00352	345	400	367	367	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ALDH1A1	P00352	168	211	177	177	Natural variant	ID=VAR_017778;Note=I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs8187929
ALDH1A1	P00352	453	477	458	458	Mutagenesis	Note=No significant effect on aldehyde dehydrogenase activity. Prevents the inhibition by ALDH1A1-specific inhibitors. G->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25634381;Dbxref=PMID:25634381
ALDH1A1	P00352	168	211	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	168	211	172	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	168	211	189	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	211	249	200	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	168	211	200	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	211	249	218	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	211	249	226	228	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	211	249	229	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	211	249	241	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	211	249	248	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	345	400	348	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	345	400	367	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	345	400	373	379	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	345	400	385	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	345	400	395	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	453	477	450	455	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	453	477	470	472	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
ALDH1A1	P00352	453	477	473	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2M
AKR1C1	Q04828	28	84	1	323	Chain	ID=PRO_0000124633;Note=Aldo-keto reductase family 1 member C1
AKR1C1	Q04828	84	123	1	323	Chain	ID=PRO_0000124633;Note=Aldo-keto reductase family 1 member C1
AKR1C1	Q04828	123	149	1	323	Chain	ID=PRO_0000124633;Note=Aldo-keto reductase family 1 member C1
AKR1C1	Q04828	28	84	55	55	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR1C1	Q04828	28	84	50	50	Binding site	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12899831,ECO:0000269|PubMed:21414777;Dbxref=PMID:12899831,PMID:21414777
AKR1C1	Q04828	84	123	117	117	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR1C1	Q04828	28	84	54	54	Site	Note=Important for substrate specificity;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR1C1	Q04828	28	84	84	84	Site	Note=Lowers pKa of active site Tyr;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR1C1	Q04828	84	123	84	84	Site	Note=Lowers pKa of active site Tyr;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR1C1	Q04828	123	149	127	127	Mutagenesis	Note=30-fold decrease in k(cat)/K(m) value for progesterone reduction%3B no effect on the K(m) value. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12899831;Dbxref=PMID:12899831
AKR1C1	Q04828	84	123	95	95	Sequence conflict	Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1C1	Q04828	84	123	95	95	Sequence conflict	Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1C1	Q04828	28	84	33	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	28	84	48	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	28	84	53	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	28	84	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	28	84	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	28	84	80	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	84	123	80	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	84	123	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	84	123	92	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	84	123	111	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
AKR1C1	Q04828	123	149	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C3U
AKR1C1	Q04828	123	149	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YVP
AKR1C1	Q04828	123	149	144	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MRQ
ACER2	Q5QJU3	122	167	1	275	Chain	ID=PRO_0000247748;Note=Alkaline ceramidase 2
ACER2	Q5QJU3	168	213	1	275	Chain	ID=PRO_0000247748;Note=Alkaline ceramidase 2
ACER2	Q5QJU3	122	167	108	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	122	167	125	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	122	167	143	143	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	122	167	144	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	122	167	165	173	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	168	213	165	173	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	168	213	174	194	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	168	213	195	211	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	168	213	212	232	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER2	Q5QJU3	168	213	169	189	Alternative sequence	ID=VSP_020034;Note=In isoform 3. CDNMRVFKLGLFSGLWWTLAL->HERNQRRRHRKGGQQGGGDKV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
ACER2	Q5QJU3	168	213	190	275	Alternative sequence	ID=VSP_020035;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
ACER2	Q5QJU3	122	167	134	134	Natural variant	ID=VAR_027150;Note=A->V;Dbxref=dbSNP:rs10964136
CHRNA6	Q15825	73	88	26	494	Chain	ID=PRO_0000000360;Note=Neuronal acetylcholine receptor subunit alpha-6
CHRNA6	Q15825	73	88	26	239	Topological domain	Note=Extracellular
CHRNA6	Q15825	73	88	74	88	Alternative sequence	ID=VSP_042713;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHRNG	P07510	117	168	23	517	Chain	ID=PRO_0000000334;Note=Acetylcholine receptor subunit gamma
CHRNG	P07510	117	168	23	240	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHRNG	P07510	117	168	163	163	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHRNG	P07510	117	168	150	164	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CHRNG	P07510	117	168	117	169	Alternative sequence	ID=VSP_055775;Note=In isoform 2. NVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQ->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHRNG	P07510	117	168	149	149	Natural variant	ID=VAR_030754;Note=A->T;Dbxref=dbSNP:rs2289080
ACSS2	Q9NR19	489	516	1	701	Chain	ID=PRO_0000208423;Note=Acetyl-coenzyme A synthetase%2C cytoplasmic
ACSS2	Q9NR19	575	634	1	701	Chain	ID=PRO_0000208423;Note=Acetyl-coenzyme A synthetase%2C cytoplasmic
ACSS2	Q9NR19	575	634	575	575	Binding site	Note=Coenzyme A%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSS2	Q9NR19	575	634	615	615	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACSL3	O95573	360	384	1	720	Chain	ID=PRO_0000193107;Note=Long-chain-fatty-acid--CoA ligase 3
ACSL3	O95573	488	513	1	720	Chain	ID=PRO_0000193107;Note=Long-chain-fatty-acid--CoA ligase 3
ACSL3	O95573	360	384	1	720	Chain	ID=PRO_0000193107;Note=Long-chain-fatty-acid--CoA ligase 3
ACSL3	O95573	488	513	1	720	Chain	ID=PRO_0000193107;Note=Long-chain-fatty-acid--CoA ligase 3
ACSL3	O95573	360	384	42	720	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL3	O95573	488	513	42	720	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL3	O95573	360	384	42	720	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL3	O95573	488	513	42	720	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSM3	Q53FZ2	213	260	28	586	Chain	ID=PRO_0000306097;Note=Acyl-coenzyme A synthetase ACSM3%2C mitochondrial
ACSM3	Q53FZ2	408	442	28	586	Chain	ID=PRO_0000306097;Note=Acyl-coenzyme A synthetase ACSM3%2C mitochondrial
ACSM3	Q53FZ2	518	558	28	586	Chain	ID=PRO_0000306097;Note=Acyl-coenzyme A synthetase ACSM3%2C mitochondrial
ACSM3	Q53FZ2	213	260	235	243	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSM3	Q53FZ2	408	442	409	438	Alternative sequence	ID=VSP_028395;Note=In isoform 2. IVDVNGNVLPPGQEGDIGIQVLPNRPFGLF->VCTSPSRRMFNNPICTLPTYRLPPYKLSLL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7843754;Dbxref=PMID:15489334,PMID:7843754
ACSM3	Q53FZ2	408	442	439	586	Alternative sequence	ID=VSP_028396;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7843754;Dbxref=PMID:15489334,PMID:7843754
ACSM3	Q53FZ2	518	558	439	586	Alternative sequence	ID=VSP_028396;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7843754;Dbxref=PMID:15489334,PMID:7843754
ACSM3	Q53FZ2	213	260	237	237	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACSM3	Q53FZ2	213	260	245	245	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACSM5	Q6NUN0	208	255	27	579	Chain	ID=PRO_0000306101;Note=Acyl-coenzyme A synthetase ACSM5%2C mitochondrial
ACSM5	Q6NUN0	208	255	230	238	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSM5	Q6NUN0	208	255	209	579	Alternative sequence	ID=VSP_028398;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACSM5	Q6NUN0	208	255	217	217	Natural variant	ID=VAR_061011;Note=M->V;Dbxref=dbSNP:rs59025904
ACSM5	Q6NUN0	208	255	231	234	Sequence conflict	Note=SGTT->KREPP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADCY5	O95622	814	853	1	1261	Chain	ID=PRO_0000195694;Note=Adenylate cyclase type 5
ADCY5	O95622	814	853	836	856	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY6	O43306	761	814	1	1168	Chain	ID=PRO_0000195699;Note=Adenylate cyclase type 6
ADCY6	O43306	722	761	1	1168	Chain	ID=PRO_0000195699;Note=Adenylate cyclase type 6
ADCY6	O43306	722	761	743	759	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY6	O43306	761	814	760	819	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY6	O43306	722	761	760	819	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY6	O43306	761	814	793	793	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY6	O43306	761	814	762	814	Alternative sequence	ID=VSP_000244;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477
ADRM1	Q16186	71	110	2	407	Chain	ID=PRO_0000020631;Note=Proteasomal ubiquitin receptor ADRM1
ADRM1	Q16186	151	180	2	407	Chain	ID=PRO_0000020631;Note=Proteasomal ubiquitin receptor ADRM1
ADRM1	Q16186	71	110	22	130	Region	Note=Pru (pleckstrin-like receptor for ubiquitin) domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18497817;Dbxref=PMID:18497817
ADRM1	Q16186	151	180	135	202	Compositional bias	Note=Gly-rich
ADRM1	Q16186	71	110	69	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V1Y
ADRM1	Q16186	71	110	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V1Y
ADRM1	Q16186	71	110	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V1Y
ADRM1	Q16186	71	110	93	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V1Y
ADRM1	Q16186	71	110	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KR0
ADRM1	Q16186	71	110	104	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V1Y
MLLT10	P55197	201	233	1	1068	Chain	ID=PRO_0000215935;Note=Protein AF-10
MLLT10	P55197	350	540	1	1068	Chain	ID=PRO_0000215935;Note=Protein AF-10
MLLT10	P55197	555	566	1	1068	Chain	ID=PRO_0000215935;Note=Protein AF-10
MLLT10	P55197	566	582	1	1068	Chain	ID=PRO_0000215935;Note=Protein AF-10
MLLT10	P55197	201	233	80	287	Region	Note=Self-association
MLLT10	P55197	201	233	141	233	Region	Note=Interaction with FSTL3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17868029;Dbxref=PMID:17868029
MLLT10	P55197	350	540	311	674	Region	Note=DNA-binding
MLLT10	P55197	555	566	311	674	Region	Note=DNA-binding
MLLT10	P55197	566	582	311	674	Region	Note=DNA-binding
MLLT10	P55197	201	233	229	240	Compositional bias	Note=Glu/Lys-rich
MLLT10	P55197	201	233	217	217	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MLLT10	P55197	350	540	436	436	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MLLT10	P55197	350	540	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O54826
MLLT10	P55197	201	233	127	1068	Alternative sequence	ID=VSP_043045;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	350	540	127	1068	Alternative sequence	ID=VSP_043045;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	555	566	127	1068	Alternative sequence	ID=VSP_043045;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	566	582	127	1068	Alternative sequence	ID=VSP_043045;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	201	233	180	1068	Alternative sequence	ID=VSP_044553;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	350	540	180	1068	Alternative sequence	ID=VSP_044553;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	555	566	180	1068	Alternative sequence	ID=VSP_044553;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	566	582	180	1068	Alternative sequence	ID=VSP_044553;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MLLT10	P55197	555	566	566	566	Alternative sequence	ID=VSP_047517;Note=In isoform 1. N->NDRGDSSTLTKQELKFI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7888665;Dbxref=PMID:7888665
MLLT10	P55197	566	582	566	566	Alternative sequence	ID=VSP_047517;Note=In isoform 1. N->NDRGDSSTLTKQELKFI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7888665;Dbxref=PMID:7888665
AFTPH	Q6ULP2	738	757	1	936	Chain	ID=PRO_0000064488;Note=Aftiphilin
AFTPH	Q6ULP2	757	798	1	936	Chain	ID=PRO_0000064488;Note=Aftiphilin
AFTPH	Q6ULP2	818	846	1	936	Chain	ID=PRO_0000064488;Note=Aftiphilin
AFTPH	Q6ULP2	738	757	1	936	Chain	ID=PRO_0000064488;Note=Aftiphilin
AFTPH	Q6ULP2	757	798	1	936	Chain	ID=PRO_0000064488;Note=Aftiphilin
AFTPH	Q6ULP2	818	846	1	936	Chain	ID=PRO_0000064488;Note=Aftiphilin
AFTPH	Q6ULP2	818	846	825	829	Region	Note=Clathrin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
AFTPH	Q6ULP2	818	846	825	829	Region	Note=Clathrin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
AFTPH	Q6ULP2	818	846	819	846	Alternative sequence	ID=VSP_059492;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
AFTPH	Q6ULP2	818	846	819	846	Alternative sequence	ID=VSP_059492;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
AFTPH	Q6ULP2	818	846	819	820	Alternative sequence	ID=VSP_059493;Note=In isoform 3. AS->GT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AFTPH	Q6ULP2	818	846	819	820	Alternative sequence	ID=VSP_059493;Note=In isoform 3. AS->GT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AFTPH	Q6ULP2	818	846	821	936	Alternative sequence	ID=VSP_059494;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AFTPH	Q6ULP2	818	846	821	936	Alternative sequence	ID=VSP_059494;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SPATA5	Q8NB90	623	693	1	893	Chain	ID=PRO_0000330583;Note=ATPase family protein 2 homolog
SPATA5	Q8NB90	693	711	1	893	Chain	ID=PRO_0000330583;Note=ATPase family protein 2 homolog
SPATA5	Q8NB90	623	693	668	675	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32794
SPATA5	Q8NB90	693	711	694	696	Alternative sequence	ID=VSP_033046;Note=In isoform 3. GPE->VGC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPATA5	Q8NB90	693	711	697	893	Alternative sequence	ID=VSP_033047;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPATA5	Q8NB90	623	693	626	626	Natural variant	ID=VAR_075782;Note=In EHLMRS. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299366;Dbxref=dbSNP:rs796052222,PMID:26299366
SPATA5	Q8NB90	623	693	628	628	Natural variant	ID=VAR_075783;Note=In EHLMRS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299366;Dbxref=dbSNP:rs768528444,PMID:26299366
SPATA5	Q8NB90	623	693	673	673	Natural variant	ID=VAR_042704;Note=S->Y;Dbxref=dbSNP:rs35133326
SPATA5	Q8NB90	693	711	695	695	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AASDHPPT	Q9NRN7	231	255	1	309	Chain	ID=PRO_0000175736;Note=L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
AASDHPPT	Q9NRN7	231	255	139	309	Alternative sequence	ID=VSP_055784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AASDHPPT	Q9NRN7	231	255	228	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C43
AASDHPPT	Q9NRN7	231	255	239	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C43
ACER3	Q9NUN7	34	71	1	267	Chain	ID=PRO_0000212463;Note=Alkaline ceramidase 3
ACER3	Q9NUN7	134	146	1	267	Chain	ID=PRO_0000212463;Note=Alkaline ceramidase 3
ACER3	Q9NUN7	166	199	1	267	Chain	ID=PRO_0000212463;Note=Alkaline ceramidase 3
ACER3	Q9NUN7	34	71	29	51	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER3	Q9NUN7	34	71	63	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER3	Q9NUN7	134	146	118	137	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER3	Q9NUN7	166	199	147	169	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER3	Q9NUN7	166	199	174	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACER3	Q9NUN7	34	71	1	133	Alternative sequence	ID=VSP_039162;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACER3	Q9NUN7	134	146	134	145	Alternative sequence	ID=VSP_039163;Note=In isoform 2. TVYLKVKEPIFH->MAQSRLIGTSTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACER3	Q9NUN7	34	71	52	52	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACER3	Q9NUN7	34	71	52	52	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACER3	Q9NUN7	34	71	52	52	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACER3	Q9NUN7	34	71	52	52	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACER3	Q9NUN7	34	71	52	52	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACTL6B	O94805	371	400	1	426	Chain	ID=PRO_0000089135;Note=Actin-like protein 6B
ACTL6B	O94805	312	339	1	426	Chain	ID=PRO_0000089135;Note=Actin-like protein 6B
ACSL6	Q9UKU0	571	619	1	697	Chain	ID=PRO_0000193115;Note=Long-chain-fatty-acid--CoA ligase 6
ACSL6	Q9UKU0	446	478	1	697	Chain	ID=PRO_0000193115;Note=Long-chain-fatty-acid--CoA ligase 6
ACSL6	Q9UKU0	330	356	1	697	Chain	ID=PRO_0000193115;Note=Long-chain-fatty-acid--CoA ligase 6
ACSL6	Q9UKU0	571	619	46	697	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL6	Q9UKU0	446	478	46	697	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL6	Q9UKU0	330	356	46	697	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACSL6	Q9UKU0	330	356	306	345	Alternative sequence	ID=VSP_037822;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACSL6	Q9UKU0	330	356	306	330	Alternative sequence	ID=VSP_021024;Note=In isoform 3%2C isoform 2 and isoform 8. KVIFPRQDDVLISFLPLAHMFERVI->SQWAPTCADVHISYLPLAHMFERMV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10502316,ECO:0000303|PubMed:10548543;Dbxref=PMID:10502316,PMID:10548543
ACSL6	Q9UKU0	330	356	356	356	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADCY1	Q08828	213	263	1	1119	Chain	ID=PRO_0000195682;Note=Adenylate cyclase type 1
ADCY1	Q08828	213	263	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY1	Q08828	213	263	235	610	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM7	Q9H2U9	614	641	177	754	Chain	ID=PRO_0000029053;Note=Disintegrin and metalloproteinase domain-containing protein 7
ADAM7	Q9H2U9	614	641	19	668	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM7	Q9H2U9	614	641	489	668	Compositional bias	Note=Cys-rich
ADAM7	Q9H2U9	614	641	211	754	Alternative sequence	ID=VSP_056603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ADAM7	Q9H2U9	614	641	638	638	Natural variant	ID=VAR_046733;Note=N->H;Dbxref=dbSNP:rs13259668
ADAM7	Q9H2U9	614	641	639	639	Natural variant	ID=VAR_066307;Note=In a cutaneous metastatic melanoma sample%3B somatic mutation%3B does not affect cell growth but conferes reduced cell adhesion to collagen IV and laminin-1%3B increases cell migration capabilities compared to wild-type. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618342;Dbxref=dbSNP:rs1034941983,PMID:21618342
ADAM8	P78325	773	799	17	824	Chain	ID=PRO_0000029060;Note=Disintegrin and metalloproteinase domain-containing protein 8
ADAM8	P78325	595	621	17	824	Chain	ID=PRO_0000029060;Note=Disintegrin and metalloproteinase domain-containing protein 8
ADAM8	P78325	595	621	17	655	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM8	P78325	773	799	677	824	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM8	P78325	595	621	609	641	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
ADAM8	P78325	595	621	612	612	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM8	P78325	595	621	566	613	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741
ADAM8	P78325	595	621	613	623	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAM8	P78325	595	621	617	629	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAM8	P78325	595	621	596	621	Alternative sequence	ID=VSP_046156;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAM8	P78325	773	799	743	824	Alternative sequence	ID=VSP_046158;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ADAM8	P78325	773	799	774	799	Alternative sequence	ID=VSP_046159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAM8	P78325	773	799	775	775	Natural variant	ID=VAR_061737;Note=I->T;Dbxref=dbSNP:rs3008319
ADCY3	O60266	859	912	1	1144	Chain	ID=PRO_0000195687;Note=Adenylate cyclase type 3
ADCY3	O60266	811	831	1	1144	Chain	ID=PRO_0000195687;Note=Adenylate cyclase type 3
ADCY3	O60266	859	912	854	1144	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AEBP1	Q8IUX7	222	246	26	1158	Chain	ID=PRO_0000333189;Note=Adipocyte enhancer-binding protein 1
AEBP1	Q8IUX7	246	287	26	1158	Chain	ID=PRO_0000333189;Note=Adipocyte enhancer-binding protein 1
AEBP1	Q8IUX7	313	339	26	1158	Chain	ID=PRO_0000333189;Note=Adipocyte enhancer-binding protein 1
AEBP1	Q8IUX7	679	739	26	1158	Chain	ID=PRO_0000333189;Note=Adipocyte enhancer-binding protein 1
AEBP1	Q8IUX7	679	739	555	985	Region	Note=Interaction with PTEN;Ontology_term=ECO:0000250;evidence=ECO:0000250
AEBP1	Q8IUX7	222	246	47	326	Compositional bias	Note=Pro-rich
AEBP1	Q8IUX7	246	287	47	326	Compositional bias	Note=Pro-rich
AEBP1	Q8IUX7	313	339	47	326	Compositional bias	Note=Pro-rich
AEBP1	Q8IUX7	222	246	1	457	Alternative sequence	ID=VSP_033467;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AEBP1	Q8IUX7	246	287	1	457	Alternative sequence	ID=VSP_033467;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AEBP1	Q8IUX7	313	339	1	457	Alternative sequence	ID=VSP_033467;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AEBP1	Q8IUX7	246	287	273	273	Natural variant	ID=VAR_043118;Note=P->T;Dbxref=dbSNP:rs2537188
AEBP1	Q8IUX7	679	739	581	1158	Natural variant	ID=VAR_080664;Note=In EDSCLL2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29606302;Dbxref=PMID:29606302
AEBP1	Q8IUX7	679	739	715	715	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACOT9	Q9Y305	124	152	22	439	Chain	ID=PRO_0000053812;Note=Acyl-coenzyme A thioesterase 9%2C mitochondrial
ACOT9	Q9Y305	55	111	22	439	Chain	ID=PRO_0000053812;Note=Acyl-coenzyme A thioesterase 9%2C mitochondrial
ACOT9	Q9Y305	124	152	84	209	Domain	Note=HotDog ACOT-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01106
ACOT9	Q9Y305	55	111	84	209	Domain	Note=HotDog ACOT-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01106
ACOT9	Q9Y305	55	111	103	103	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACOT9	Q9Y305	55	111	1	60	Alternative sequence	ID=VSP_036420;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHRND	Q07001	66	81	22	517	Chain	ID=PRO_0000000322;Note=Acetylcholine receptor subunit delta
CHRND	Q07001	206	273	22	517	Chain	ID=PRO_0000000322;Note=Acetylcholine receptor subunit delta
CHRND	Q07001	66	81	22	245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHRND	Q07001	206	273	22	245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHRND	Q07001	206	273	246	270	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHRND	Q07001	66	81	67	81	Alternative sequence	ID=VSP_046423;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHRND	Q07001	66	81	79	79	Natural variant	ID=VAR_073692;Note=In CMS3B%3B prevents expression of the AChR on the cell surface%3B is a null mutation. I->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18398509;Dbxref=dbSNP:rs121909509,PMID:18398509
CHRND	Q07001	66	81	80	80	Natural variant	ID=VAR_021210;Note=In CMS3B%3B reduced adult and fetal AChR expression and a reduced probability of both adult and fetal AChR being in the open state. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11435464;Dbxref=dbSNP:rs121909504,PMID:11435464
CHRND	Q07001	206	273	271	271	Natural variant	ID=VAR_021211;Note=In CMS3B%3B burst duration was decreased and disassociation of ACh was increased resulting in brief channel opening episodes%3B shows abnormal association with alpha CHRNA1 subunit resulting in a decreased number of fully assembled AChRs. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12499478;Dbxref=dbSNP:rs121909503,PMID:12499478
ACOT12	Q8WYK0	348	376	1	555	Chain	ID=PRO_0000053809;Note=Acyl-coenzyme A thioesterase 12
ACOT12	Q8WYK0	86	120	1	555	Chain	ID=PRO_0000053809;Note=Acyl-coenzyme A thioesterase 12
ACOT12	Q8WYK0	86	120	5	117	Domain	Note=HotDog ACOT-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01106
ACOT12	Q8WYK0	348	376	340	549	Domain	Note=START;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00197
ACOT12	Q8WYK0	348	376	168	555	Alternative sequence	ID=VSP_055786;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACOT12	Q8WYK0	86	120	82	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOB
ACOT12	Q8WYK0	86	120	96	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOB
ACOT12	Q8WYK0	86	120	101	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOB
ACOT12	Q8WYK0	86	120	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOB
ADAL	Q6DHV7	184	211	1	355	Chain	ID=PRO_0000285090;Note=Adenosine deaminase-like protein
ADAL	Q6DHV7	184	211	211	211	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAL	Q6DHV7	184	211	208	208	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAL	Q6DHV7	184	211	185	211	Alternative sequence	ID=VSP_042782;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADAM2	Q99965	171	190	17	174	Propeptide	ID=PRO_0000029042
ADAM2	Q99965	171	190	175	735	Chain	ID=PRO_0000029043;Note=Disintegrin and metalloproteinase domain-containing protein 2
ADAM2	Q99965	171	190	175	686	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM2	Q99965	171	190	178	375	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM2	Q99965	171	190	172	190	Alternative sequence	ID=VSP_005471;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ADA	P00813	202	226	2	363	Chain	ID=PRO_0000194352;Note=Adenosine deaminase
ADA	P00813	202	226	217	217	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03958
ADA	P00813	202	226	214	214	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.24
ADA	P00813	202	226	211	211	Natural variant	ID=VAR_002231;Note=In ADASCID%3B late onset%3B 4%25 of activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2166947,ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs121908740,PMID:2166947,PMID:9361033
ADA	P00813	202	226	211	211	Natural variant	ID=VAR_002232;Note=In ADASCID. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3182793;Dbxref=dbSNP:rs121908716,PMID:3182793
ADA	P00813	202	226	215	215	Natural variant	ID=VAR_002233;Note=In ADASCID%3B 8%25 of activity. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2166947,ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs114025668,PMID:2166947,PMID:9361033
ADA	P00813	202	226	216	216	Natural variant	ID=VAR_002234;Note=In ADASCID%3B severe. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8227344;Dbxref=dbSNP:rs121908723,PMID:8227344
ADA	P00813	202	226	195	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IAR
ADA	P00813	202	226	210	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IAR
ADA	P00813	202	226	221	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IAR
SLC25A4	P12235	199	246	2	298	Chain	ID=PRO_0000090574;Note=ADP/ATP translocase 1
SLC25A4	P12235	199	246	179	199	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02722
SLC25A4	P12235	199	246	211	231	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02722
SLC25A4	P12235	199	246	111	201	Repeat	Note=Solcar 2
SLC25A4	P12235	199	246	212	297	Repeat	Note=Solcar 3
SLC25A4	P12235	199	246	235	240	Region	Note=Important for transport activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27693233;Dbxref=PMID:27693233
SLC25A4	P12235	199	246	235	240	Motif	Note=Nucleotide carrier signature motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02722
SLC25A4	P12235	199	246	235	235	Binding site	Note=ADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02722
SLC25A4	P12235	199	246	245	245	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48962
SLC25A4	P12235	199	246	235	235	Natural variant	ID=VAR_078072;Note=In MTDPS12A%3B severely decreased function in ADP transport. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27693233;Dbxref=dbSNP:rs886041082,PMID:27693233
SLC25A4	P12235	199	246	236	236	Natural variant	ID=VAR_078073;Note=In MTDPS12B%3B loss of function in ADP transport. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25732997,ECO:0000269|PubMed:27693233;Dbxref=dbSNP:rs770816416,PMID:25732997,PMID:27693233
SLC25A4	P12235	199	246	227	227	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLLT3	P42568	501	525	1	568	Chain	ID=PRO_0000215921;Note=Protein AF-9
MLLT3	P42568	477	501	1	568	Chain	ID=PRO_0000215921;Note=Protein AF-9
MLLT3	P42568	140	375	1	568	Chain	ID=PRO_0000215921;Note=Protein AF-9
MLLT3	P42568	140	375	295	300	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MLLT3	P42568	140	375	149	194	Compositional bias	Note=Poly-Ser
MLLT3	P42568	140	375	375	375	Site	Note=KMT2A/MLL1 fusion point (in acute myeloid leukemia patient CO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8506309;Dbxref=PMID:8506309
MLLT3	P42568	477	501	481	481	Site	Note=KMT2A/MLL1 fusion point (in acute myeloid leukemia patient F1);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8506309;Dbxref=PMID:8506309
MLLT3	P42568	140	375	288	288	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
MLLT3	P42568	140	375	294	294	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:23186163
MLLT3	P42568	477	501	483	483	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:23186163
MLLT3	P42568	140	375	339	339	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
MLLT3	P42568	140	375	173	173	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MLLT3	P42568	501	525	504	515	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LM0
MLLT3	P42568	501	525	523	531	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LM0
ACADM	P11310	129	156	26	421	Chain	ID=PRO_0000000502;Note=Medium-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADM	P11310	236	283	26	421	Chain	ID=PRO_0000000502;Note=Medium-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADM	P11310	283	315	26	421	Chain	ID=PRO_0000000502;Note=Medium-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADM	P11310	315	398	26	421	Chain	ID=PRO_0000000502;Note=Medium-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADM	P11310	283	315	306	308	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8823176;Dbxref=PMID:8823176
ACADM	P11310	315	398	316	317	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8823176;Dbxref=PMID:8823176
ACADM	P11310	315	398	374	378	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8823176;Dbxref=PMID:8823176
ACADM	P11310	236	283	278	281	Region	Note=Substrate binding
ACADM	P11310	236	283	259	259	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P45952
ACADM	P11310	236	283	259	259	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P45952
ACADM	P11310	236	283	271	271	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P45952
ACADM	P11310	236	283	271	271	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P45952
ACADM	P11310	236	283	279	279	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACADM	P11310	283	315	301	301	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACADM	P11310	315	398	351	351	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P45952
ACADM	P11310	129	156	132	132	Natural variant	ID=VAR_035716;Note=In a breast cancer sample%3B somatic mutation. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs875989854,PMID:16959974
ACADM	P11310	129	156	149	149	Natural variant	ID=VAR_000319;Note=In ACADMD. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1684086;Dbxref=dbSNP:rs121434277,PMID:1684086
ACADM	P11310	236	283	244	244	Natural variant	ID=VAR_000322;Note=In ACADMD. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1684086;Dbxref=dbSNP:rs121434276,PMID:1684086
ACADM	P11310	236	283	245	245	Natural variant	ID=VAR_013699;Note=In ACADMD. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11409868;Dbxref=dbSNP:rs121434281,PMID:11409868
ACADM	P11310	236	283	267	267	Natural variant	ID=VAR_000323;Note=In ACADMD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1684086;Dbxref=dbSNP:rs121434274,PMID:1684086
ACADM	P11310	236	283	281	281	Natural variant	ID=VAR_013700;Note=In ACADMD%3B mild or benign clinical phenotype. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11486912;Dbxref=dbSNP:rs121434282,PMID:11486912
ACADM	P11310	283	315	310	310	Natural variant	ID=VAR_015958;Note=In ACADMD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349232;Dbxref=dbSNP:rs747268471,PMID:11349232
ACADM	P11310	315	398	326	326	Natural variant	ID=VAR_000324;Note=In ACADMD. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8198141;Dbxref=dbSNP:rs786204631,PMID:8198141
ACADM	P11310	315	398	329	329	Natural variant	ID=VAR_000325;Note=In ACADMD%3B most common variant. K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10767181,ECO:0000269|PubMed:11486912,ECO:0000269|PubMed:1902818,ECO:0000269|PubMed:2251268,ECO:0000269|PubMed:2393404,ECO:0000269|PubMed:2394825;Dbxref=dbSNP:rs77931234,PMID:10767181,PMID:11486912,PMID:1902818,PMID:2251268,PMID:2393404,PMID:2394825
ACADM	P11310	315	398	336	336	Natural variant	ID=VAR_000326;Note=In ACADMD. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8198141;Dbxref=PMID:8198141
ACADM	P11310	315	398	352	352	Natural variant	ID=VAR_015959;Note=In ACADMD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9158144;Dbxref=PMID:9158144
ACADM	P11310	315	398	375	375	Natural variant	ID=VAR_000327;Note=In ACADMD. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1684086;Dbxref=dbSNP:rs121434275,PMID:1684086
ACADM	P11310	236	283	237	237	Mutagenesis	Note=Strongly reduced rate of electron transfer to ETF. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15159392,ECO:0000269|PubMed:15975918;Dbxref=PMID:15159392,PMID:15975918
ACADM	P11310	315	398	384	384	Mutagenesis	Note=Reduces rate of electron transfer to ETF three-fold. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15159392,ECO:0000269|PubMed:15975918;Dbxref=PMID:15159392,PMID:15975918
ACADM	P11310	315	398	384	384	Mutagenesis	Note=Reduces rate of electron transfer to ETF two-fold. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15159392,ECO:0000269|PubMed:15975918;Dbxref=PMID:15159392,PMID:15975918
ACADM	P11310	315	398	356	356	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACADM	P11310	129	156	117	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	129	156	139	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	129	156	147	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	129	156	155	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	236	283	231	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	236	283	239	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	236	283	247	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	236	283	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	236	283	262	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	236	283	266	268	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EGE
ACADM	P11310	236	283	269	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	283	315	269	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	283	315	309	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EGC
ACADM	P11310	283	315	313	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	315	398	313	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	315	398	317	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	315	398	351	376	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	315	398	377	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	315	398	387	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACADM	P11310	315	398	395	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P13
ACIN1	Q9UKV3	1055	1091	1	1341	Chain	ID=PRO_0000064436;Note=Apoptotic chromatin condensation inducer in the nucleus
ACIN1	Q9UKV3	1019	1055	1	1341	Chain	ID=PRO_0000064436;Note=Apoptotic chromatin condensation inducer in the nucleus
ACIN1	Q9UKV3	872	923	1	1341	Chain	ID=PRO_0000064436;Note=Apoptotic chromatin condensation inducer in the nucleus
ACIN1	Q9UKV3	654	727	1	1341	Chain	ID=PRO_0000064436;Note=Apoptotic chromatin condensation inducer in the nucleus
ACIN1	Q9UKV3	163	203	1	1341	Chain	ID=PRO_0000064436;Note=Apoptotic chromatin condensation inducer in the nucleus
ACIN1	Q9UKV3	104	126	1	1341	Chain	ID=PRO_0000064436;Note=Apoptotic chromatin condensation inducer in the nucleus
ACIN1	Q9UKV3	104	126	72	106	Domain	Note=SAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00186
ACIN1	Q9UKV3	163	203	142	442	Compositional bias	Note=Glu-rich
ACIN1	Q9UKV3	654	727	573	676	Compositional bias	Note=Ser-rich
ACIN1	Q9UKV3	163	203	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
ACIN1	Q9UKV3	163	203	169	169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
ACIN1	Q9UKV3	654	727	654	654	Modified residue	Note=N6%2CN6%2CN6-trimethyllysine%3B by EHMT2%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18438403;Dbxref=PMID:18438403
ACIN1	Q9UKV3	654	727	654	654	Modified residue	Note=N6%2CN6-dimethyllysine%3B by EHMT2%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18438403;Dbxref=PMID:18438403
ACIN1	Q9UKV3	654	727	655	655	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
ACIN1	Q9UKV3	654	727	657	657	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
ACIN1	Q9UKV3	654	727	682	682	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ACIN1	Q9UKV3	654	727	710	710	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19367720,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
ACIN1	Q9UKV3	654	727	714	714	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
ACIN1	Q9UKV3	654	727	717	717	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACIN1	Q9UKV3	654	727	720	720	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ACIN1	Q9UKV3	872	923	895	895	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18220336;Dbxref=PMID:18220336
ACIN1	Q9UKV3	872	923	898	898	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:24275569;Dbxref=PMID:18220336,PMID:24275569
ACIN1	Q9UKV3	872	923	879	879	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ACIN1	Q9UKV3	1019	1055	1047	1047	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ACIN1	Q9UKV3	654	727	1	758	Alternative sequence	ID=VSP_004026;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10490026,ECO:0000303|Ref.2;Dbxref=PMID:10490026
ACIN1	Q9UKV3	163	203	1	758	Alternative sequence	ID=VSP_004026;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10490026,ECO:0000303|Ref.2;Dbxref=PMID:10490026
ACIN1	Q9UKV3	104	126	1	758	Alternative sequence	ID=VSP_004026;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10490026,ECO:0000303|Ref.2;Dbxref=PMID:10490026
ACIN1	Q9UKV3	654	727	1	727	Alternative sequence	ID=VSP_004025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10490026;Dbxref=PMID:10490026
ACIN1	Q9UKV3	163	203	1	727	Alternative sequence	ID=VSP_004025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10490026;Dbxref=PMID:10490026
ACIN1	Q9UKV3	104	126	1	727	Alternative sequence	ID=VSP_004025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10490026;Dbxref=PMID:10490026
ACIN1	Q9UKV3	872	923	873	884	Alternative sequence	ID=VSP_042205;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACIN1	Q9UKV3	1019	1055	1025	1032	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ACIN1	Q9UKV3	1019	1055	1040	1042	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ACIN1	Q9UKV3	1055	1091	1049	1058	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ACIN1	Q9UKV3	1019	1055	1049	1058	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ACIN1	Q9UKV3	1055	1091	1059	1069	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ACIN1	Q9UKV3	1055	1091	1083	1087	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ACIN1	Q9UKV3	1055	1091	1089	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G6S
ADD3	Q9UEY8	287	320	2	706	Chain	ID=PRO_0000218536;Note=Gamma-adducin
ADD3	Q9UEY8	320	381	2	706	Chain	ID=PRO_0000218536;Note=Gamma-adducin
ADD3	Q9UEY8	467	507	2	706	Chain	ID=PRO_0000218536;Note=Gamma-adducin
ADD3	Q9UEY8	577	609	2	706	Chain	ID=PRO_0000218536;Note=Gamma-adducin
ADD3	Q9UEY8	577	609	585	585	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QYB5
ADD3	Q9UEY8	577	609	590	590	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QYB5
ADD3	Q9UEY8	467	507	484	484	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ADD3	Q9UEY8	577	609	576	607	Alternative sequence	ID=VSP_000188;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:8893809,ECO:0000303|Ref.2;Dbxref=PMID:17974005,PMID:8893809
ADD3	Q9UEY8	320	381	367	367	Natural variant	ID=VAR_076996;Note=In CPSQ3%3B decreased actin capping activity%3B increased fibroblast proliferation and migration%3B decreased colocalization with alpha subunit ADD1. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23836506;Dbxref=dbSNP:rs564185858,PMID:23836506
ADD3	Q9UEY8	320	381	362	362	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADD3	Q9UEY8	467	507	484	484	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADCY7	P51828	57	125	1	1080	Chain	ID=PRO_0000195703;Note=Adenylate cyclase type 7
ADCY7	P51828	125	179	1	1080	Chain	ID=PRO_0000195703;Note=Adenylate cyclase type 7
ADCY7	P51828	645	687	1	1080	Chain	ID=PRO_0000195703;Note=Adenylate cyclase type 7
ADCY7	P51828	57	125	1	1080	Chain	ID=PRO_0000195703;Note=Adenylate cyclase type 7
ADCY7	P51828	125	179	1	1080	Chain	ID=PRO_0000195703;Note=Adenylate cyclase type 7
ADCY7	P51828	645	687	1	1080	Chain	ID=PRO_0000195703;Note=Adenylate cyclase type 7
ADCY7	P51828	57	125	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	57	125	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	57	125	95	117	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	57	125	95	117	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	57	125	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	125	179	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	57	125	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	125	179	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	125	179	147	167	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	125	179	147	167	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	125	179	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	125	179	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	645	687	669	688	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY7	P51828	645	687	669	688	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM28	Q9UKQ2	726	748	199	775	Chain	ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28
ADAM28	Q9UKQ2	748	769	199	775	Chain	ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28
ADAM28	Q9UKQ2	726	748	687	775	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM28	Q9UKQ2	748	769	687	775	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM28	Q9UKQ2	726	748	541	775	Alternative sequence	ID=VSP_005487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10506182;Dbxref=PMID:10506182
ADAM28	Q9UKQ2	748	769	541	775	Alternative sequence	ID=VSP_005487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10506182;Dbxref=PMID:10506182
ADAM28	Q9UKQ2	748	769	765	765	Natural variant	ID=VAR_024596;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10506182,ECO:0000269|PubMed:10587367,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7814768,PMID:10506182,PMID:10587367,PMID:15489334
ABCD4	O14678	223	239	1	606	Chain	ID=PRO_0000093312;Note=ATP-binding cassette sub-family D member 4
ABCD4	O14678	181	222	1	606	Chain	ID=PRO_0000093312;Note=ATP-binding cassette sub-family D member 4
ABCD4	O14678	181	222	190	210	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCD4	O14678	223	239	39	332	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCD4	O14678	181	222	39	332	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ACAP2	Q15057	688	724	1	778	Chain	ID=PRO_0000074210;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 2
ACAP2	Q15057	557	588	1	778	Chain	ID=PRO_0000074210;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 2
ACAP2	Q15057	191	223	1	778	Chain	ID=PRO_0000074210;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 2
ACAP2	Q15057	176	191	1	778	Chain	ID=PRO_0000074210;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 2
ACAP2	Q15057	191	223	1	226	Domain	Note=BAR
ACAP2	Q15057	176	191	1	226	Domain	Note=BAR
ACAP2	Q15057	688	724	673	702	Repeat	Note=ANK 2
ACAP2	Q15057	688	724	706	735	Repeat	Note=ANK 3
ACAP2	Q15057	557	588	581	581	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ACAP2	Q15057	557	588	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZQK5
ACAP2	Q15057	557	588	564	564	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB10	Q9NRK6	446	478	106	738	Chain	ID=PRO_0000000255;Note=ATP-binding cassette sub-family B member 10%2C mitochondrial
ABCB10	Q9NRK6	307	352	106	738	Chain	ID=PRO_0000000255;Note=ATP-binding cassette sub-family B member 10%2C mitochondrial
ABCB10	Q9NRK6	307	352	237	312	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCB10	Q9NRK6	307	352	313	333	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB10	Q9NRK6	307	352	334	407	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCB10	Q9NRK6	446	478	431	451	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB10	Q9NRK6	446	478	452	738	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCB10	Q9NRK6	446	478	171	457	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB10	Q9NRK6	307	352	171	457	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB10	Q9NRK6	446	478	471	471	Natural variant	ID=VAR_035735;Note=In a breast cancer sample%3B somatic mutation. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ABCB10	Q9NRK6	307	352	288	310	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDQ
ABCB10	Q9NRK6	307	352	312	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDQ
ABCB10	Q9NRK6	446	478	428	469	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDQ
ACE2	Q9BYF1	146	194	18	805	Chain	ID=PRO_0000028570;Note=Angiotensin-converting enzyme 2
ACE2	Q9BYF1	146	194	18	805	Chain	ID=PRO_0000028570;Note=Angiotensin-converting enzyme 2
ACE2	Q9BYF1	146	194	18	708	Chain	ID=PRO_0000292268;Note=Processed angiotensin-converting enzyme 2
ACE2	Q9BYF1	146	194	18	708	Chain	ID=PRO_0000292268;Note=Processed angiotensin-converting enzyme 2
ACE2	Q9BYF1	146	194	18	740	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACE2	Q9BYF1	146	194	18	740	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACE2	Q9BYF1	146	194	169	169	Binding site	Note=Chloride
ACE2	Q9BYF1	146	194	169	169	Binding site	Note=Chloride
ACE2	Q9BYF1	146	194	160	160	Mutagenesis	Note=No effect on interaction with SARS-CoV spike glycoprotein. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15791205;Dbxref=PMID:15791205
ACE2	Q9BYF1	146	194	160	160	Mutagenesis	Note=No effect on interaction with SARS-CoV spike glycoprotein. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15791205;Dbxref=PMID:15791205
ACE2	Q9BYF1	146	194	192	192	Mutagenesis	Note=No effect on interaction with SARS-CoV spike glycoprotein. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15791205;Dbxref=PMID:15791205
ACE2	Q9BYF1	146	194	192	192	Mutagenesis	Note=No effect on interaction with SARS-CoV spike glycoprotein. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15791205;Dbxref=PMID:15791205
ACE2	Q9BYF1	146	194	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	148	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	148	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	158	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	158	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	173	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACE2	Q9BYF1	146	194	173	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R42
ACTA2	P62736	205	269	2	377	Chain	ID=PRO_0000442603;Note=Actin%2C aortic smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA2	P62736	151	205	2	377	Chain	ID=PRO_0000442603;Note=Actin%2C aortic smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA2	P62736	86	123	2	377	Chain	ID=PRO_0000442603;Note=Actin%2C aortic smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA2	P62736	43	86	2	377	Chain	ID=PRO_0000442603;Note=Actin%2C aortic smooth muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA2	P62736	205	269	3	377	Chain	ID=PRO_0000442604;Note=Actin%2C aortic smooth muscle
ACTA2	P62736	151	205	3	377	Chain	ID=PRO_0000442604;Note=Actin%2C aortic smooth muscle
ACTA2	P62736	86	123	3	377	Chain	ID=PRO_0000442604;Note=Actin%2C aortic smooth muscle
ACTA2	P62736	43	86	3	377	Chain	ID=PRO_0000442604;Note=Actin%2C aortic smooth muscle
ACTA2	P62736	43	86	46	46	Modified residue	Note=Methionine (R)-sulfoxide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA2	P62736	43	86	49	49	Modified residue	Note=Methionine (R)-sulfoxide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA2	P62736	43	86	75	75	Modified residue	Note=Tele-methylhistidine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62739
ACTA2	P62736	86	123	86	86	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68032
ACTA2	P62736	43	86	86	86	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68032
ACTA2	P62736	43	86	52	52	Cross-link	Note=Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-272)%3B by Vibrio toxins RtxA and VgrG1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60709
ACTA2	P62736	86	123	117	117	Natural variant	ID=VAR_045915;Note=In AAT6. N->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17994018,ECO:0000269|PubMed:19409525;Dbxref=PMID:17994018,PMID:19409525
ACTA2	P62736	86	123	118	118	Natural variant	ID=VAR_045916;Note=In AAT6. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17994018,ECO:0000269|PubMed:19409525;Dbxref=dbSNP:rs112602953,PMID:17994018,PMID:19409525
ACTA2	P62736	151	205	154	154	Natural variant	ID=VAR_045919;Note=In AAT6. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17994018,ECO:0000269|PubMed:19409525;Dbxref=PMID:17994018,PMID:19409525
ACTA2	P62736	151	205	179	179	Natural variant	ID=VAR_064516;Note=In MYMY5 and MSMDYS%3B disease phenotype include smooth muscle cells dysfunction in organs throughout the body with decreased contractile function in the iris%2C bladder and gastrointestinal tract. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20734336,ECO:0000269|PubMed:20970362;Dbxref=dbSNP:rs387906592,PMID:20734336,PMID:20970362
ACTA2	P62736	151	205	185	185	Natural variant	ID=VAR_062579;Note=In AAT6. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19409525;Dbxref=dbSNP:rs1057521105,PMID:19409525
ACTA2	P62736	151	205	196	196	Natural variant	ID=VAR_011944;Note=T->S;Dbxref=dbSNP:rs1803028
ACTA2	P62736	205	269	212	212	Natural variant	ID=VAR_062580;Note=In AAT6. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19409525,ECO:0000269|PubMed:19639654;Dbxref=dbSNP:rs397516685,PMID:19409525,PMID:19639654
ACTA2	P62736	205	269	258	258	Natural variant	ID=VAR_045920;Note=In AAT6. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17994018,ECO:0000269|PubMed:19409525;Dbxref=dbSNP:rs121434528,PMID:17994018,PMID:19409525
ACTA2	P62736	205	269	258	258	Natural variant	ID=VAR_045921;Note=In AAT6. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17994018,ECO:0000269|PubMed:19409525;Dbxref=dbSNP:rs121434527,PMID:17994018,PMID:19409525
ACTA2	P62736	205	269	234	234	Sequence conflict	Note=S->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACSM1	Q08AH1	399	433	32	577	Chain	ID=PRO_0000306091;Note=Acyl-coenzyme A synthetase ACSM1%2C mitochondrial
ACSM1	Q08AH1	399	433	32	577	Chain	ID=PRO_0000306091;Note=Acyl-coenzyme A synthetase ACSM1%2C mitochondrial
ACSM1	Q08AH1	399	433	205	577	Alternative sequence	ID=VSP_028391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACSM1	Q08AH1	399	433	205	577	Alternative sequence	ID=VSP_028391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ADAM32	Q8TC27	175	198	175	787	Chain	ID=PRO_0000029139;Note=Disintegrin and metalloproteinase domain-containing protein 32
ADAM32	Q8TC27	411	442	175	787	Chain	ID=PRO_0000029139;Note=Disintegrin and metalloproteinase domain-containing protein 32
ADAM32	Q8TC27	734	746	175	787	Chain	ID=PRO_0000029139;Note=Disintegrin and metalloproteinase domain-containing protein 32
ADAM32	Q8TC27	747	759	175	787	Chain	ID=PRO_0000029139;Note=Disintegrin and metalloproteinase domain-containing protein 32
ADAM32	Q8TC27	760	772	175	787	Chain	ID=PRO_0000029139;Note=Disintegrin and metalloproteinase domain-containing protein 32
ADAM32	Q8TC27	175	198	175	682	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM32	Q8TC27	411	442	175	682	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM32	Q8TC27	734	746	704	787	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM32	Q8TC27	747	759	704	787	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM32	Q8TC27	760	772	704	787	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM32	Q8TC27	175	198	186	383	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM32	Q8TC27	411	442	391	479	Domain	Note=Disintegrin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00068
ADCK2	Q7Z695	360	403	1	626	Chain	ID=PRO_0000271792;Note=Uncharacterized aarF domain-containing protein kinase 2
ADCK2	Q7Z695	403	435	1	626	Chain	ID=PRO_0000271792;Note=Uncharacterized aarF domain-containing protein kinase 2
ADCK2	Q7Z695	435	519	1	626	Chain	ID=PRO_0000271792;Note=Uncharacterized aarF domain-containing protein kinase 2
ADCK2	Q7Z695	519	562	1	626	Chain	ID=PRO_0000271792;Note=Uncharacterized aarF domain-containing protein kinase 2
ADCK2	Q7Z695	360	403	200	618	Domain	Note=Protein kinase
ADCK2	Q7Z695	403	435	200	618	Domain	Note=Protein kinase
ADCK2	Q7Z695	435	519	200	618	Domain	Note=Protein kinase
ADCK2	Q7Z695	519	562	200	618	Domain	Note=Protein kinase
ADCK2	Q7Z695	435	519	445	445	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADCK2	Q7Z695	403	435	418	418	Natural variant	ID=VAR_041418;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3748092,PMID:17344846
ADCK2	Q7Z695	403	435	418	418	Natural variant	ID=VAR_029993;Note=V->M;Dbxref=dbSNP:rs3748092
ACTR3C	Q9C0K3	15	51	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
ACTR3C	Q9C0K3	51	99	22	210	Chain	ID=PRO_0000324333;Note=Actin-related protein 3C
ACTR3C	Q9C0K3	15	51	22	210	Chain	ID=PRO_0000324333;Note=Actin-related protein 3C
ACTR3C	Q9C0K3	51	99	1	163	Alternative sequence	ID=VSP_032218;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ACTR3C	Q9C0K3	15	51	1	163	Alternative sequence	ID=VSP_032218;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ASAH2	Q9NR71	170	229	1	780	Chain	ID=PRO_0000247099;Note=Neutral ceramidase
ASAH2	Q9NR71	170	229	99	780	Chain	ID=PRO_0000247100;Note=Neutral ceramidase soluble form;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASAH2	Q9NR71	170	229	34	780	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASAH2	Q9NR71	170	229	194	194	Metal binding	Note=Zinc%3B via tele nitrogen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4WGK,ECO:0000269|PubMed:26190575;Dbxref=PMID:26190575
ASAH2	Q9NR71	170	229	217	217	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4WGK,ECO:0000269|PubMed:26190575;Dbxref=PMID:26190575
ASAH2	Q9NR71	170	229	194	194	Mutagenesis	Note=Loss of enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26190575;Dbxref=PMID:26190575
ASAH2	Q9NR71	170	229	196	196	Mutagenesis	Note=Loss of enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26190575;Dbxref=PMID:26190575
ASAH2	Q9NR71	170	229	211	211	Mutagenesis	Note=Loss of enzyme activity. A->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26190575;Dbxref=PMID:26190575
ASAH2	Q9NR71	170	229	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WGK
ASAH2	Q9NR71	170	229	185	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WGK
ASAH2	Q9NR71	170	229	196	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WGK
ASAH2	Q9NR71	170	229	206	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WGK
ASAH2	Q9NR71	170	229	217	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WGK
ASAP1	Q9ULH1	1064	1105	1	1129	Chain	ID=PRO_0000074196;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 1
ASAP1	Q9ULH1	800	857	1	1129	Chain	ID=PRO_0000074196;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 1
ASAP1	Q9ULH1	1064	1105	1067	1129	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ASAP1	Q9ULH1	800	857	783	993	Compositional bias	Note=Pro-rich
ASAP1	Q9ULH1	800	857	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ASAP1	Q9ULH1	800	857	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:18669648,PMID:23186163
ASAP1	Q9ULH1	1064	1105	1070	1076	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED1
ASAP1	Q9ULH1	1064	1105	1081	1085	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED1
ASAP1	Q9ULH1	1064	1105	1093	1098	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED1
ASAP1	Q9ULH1	1064	1105	1101	1109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED1
ASIC3	Q9UHC3	462	486	1	531	Chain	ID=PRO_0000181301;Note=Acid-sensing ion channel 3
ASIC3	Q9UHC3	462	486	461	531	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASIC3	Q9UHC3	462	486	408	531	Alternative sequence	ID=VSP_015601;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
ATP1B2	P14415	37	80	1	290	Chain	ID=PRO_0000219104;Note=Sodium/potassium-transporting ATPase subunit beta-2
ATP1B2	P14415	37	80	1	39	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B2	P14415	37	80	40	67	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B2	P14415	37	80	68	290	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B2	P14415	37	80	51	51	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP1B2	P14415	37	80	51	51	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP13A5	Q4VNC0	314	371	1	1218	Chain	ID=PRO_0000337122;Note=Probable cation-transporting ATPase 13A5
ATP13A5	Q4VNC0	314	371	357	357	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHYKPL	Q8IUZ5	113	137	1	450	Chain	ID=PRO_0000287667;Note=5-phosphohydroxy-L-lysine phospho-lyase
PHYKPL	Q8IUZ5	113	137	1	343	Alternative sequence	ID=VSP_025585;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PHYKPL	Q8IUZ5	113	137	1	275	Alternative sequence	ID=VSP_025584;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PHYKPL	Q8IUZ5	113	137	126	126	Natural variant	ID=VAR_048233;Note=H->R;Dbxref=dbSNP:rs7707147
ATG4C	Q96DT6	53	131	1	458	Chain	ID=PRO_0000215849;Note=Cysteine protease ATG4C
ATG4C	Q96DT6	363	403	1	458	Chain	ID=PRO_0000215849;Note=Cysteine protease ATG4C
ATG4C	Q96DT6	53	131	1	458	Chain	ID=PRO_0000215849;Note=Cysteine protease ATG4C
ATG4C	Q96DT6	363	403	1	458	Chain	ID=PRO_0000215849;Note=Cysteine protease ATG4C
ATG4C	Q96DT6	53	131	111	111	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATG4C	Q96DT6	53	131	111	111	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATL2	Q8NHH9	400	544	1	583	Chain	ID=PRO_0000287105;Note=Atlastin-2
ATL2	Q8NHH9	357	376	1	583	Chain	ID=PRO_0000287105;Note=Atlastin-2
ATL2	Q8NHH9	400	544	1	476	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270207;Dbxref=PMID:18270207
ATL2	Q8NHH9	357	376	1	476	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270207;Dbxref=PMID:18270207
ATL2	Q8NHH9	400	544	477	497	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL2	Q8NHH9	400	544	498	499	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL2	Q8NHH9	400	544	500	520	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL2	Q8NHH9	400	544	521	583	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270207;Dbxref=PMID:18270207
ATL2	Q8NHH9	400	544	420	420	Natural variant	ID=VAR_032267;Note=D->H;Dbxref=dbSNP:rs7582826
ATL2	Q8NHH9	400	544	509	509	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADAMTSL4	Q6UY14	794	853	25	1074	Chain	ID=PRO_0000257966;Note=ADAMTS-like protein 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTSL4	Q6UY14	794	853	25	1074	Chain	ID=PRO_0000257966;Note=ADAMTS-like protein 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTSL4	Q6UY14	794	853	783	842	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTSL4	Q6UY14	794	853	783	842	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTSL4	Q6UY14	794	853	845	909	Domain	Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTSL4	Q6UY14	794	853	845	909	Domain	Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ATN1	P54259	9	55	1	1190	Chain	ID=PRO_0000064730;Note=Atrophin-1
ATN1	P54259	1071	1119	1	1190	Chain	ID=PRO_0000064730;Note=Atrophin-1
ATN1	P54259	9	55	1	1190	Chain	ID=PRO_0000064730;Note=Atrophin-1
ATN1	P54259	1071	1119	1	1190	Chain	ID=PRO_0000064730;Note=Atrophin-1
ATN1	P54259	9	55	16	32	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12464607;Dbxref=PMID:12464607
ATN1	P54259	9	55	16	32	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12464607;Dbxref=PMID:12464607
ATN1	P54259	9	55	34	34	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ATN1	P54259	9	55	34	34	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ATN1	P54259	1071	1119	1115	1115	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35126
ATN1	P54259	1071	1119	1115	1115	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35126
ARHGEF37	A1IGU5	298	335	1	675	Chain	ID=PRO_0000337050;Note=Rho guanine nucleotide exchange factor 37
ARHGEF37	A1IGU5	445	488	1	675	Chain	ID=PRO_0000337050;Note=Rho guanine nucleotide exchange factor 37
ARHGEF37	A1IGU5	298	335	254	455	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
ARHGEF37	A1IGU5	445	488	254	455	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
ARSD	P51689	333	378	34	593	Chain	ID=PRO_0000033424;Note=Arylsulfatase D
ARSD	P51689	333	378	356	356	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSD	P51689	333	378	357	357	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSD	P51689	333	378	347	347	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ARSD	P51689	333	378	334	382	Alternative sequence	ID=VSP_015798;Note=In isoform 2. GKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKG->ASDFMSSSEVTESEAIKLMFRTMQRRCLPSMAFKKPWRGPVRLQILKRA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11177574;Dbxref=PMID:11177574
ACTR3	P61158	75	112	2	418	Chain	ID=PRO_0000089079;Note=Actin-related protein 3
ACTR3	P61158	112	144	2	418	Chain	ID=PRO_0000089079;Note=Actin-related protein 3
ACTR3	P61158	144	180	2	418	Chain	ID=PRO_0000089079;Note=Actin-related protein 3
ACTR3	P61158	180	228	2	418	Chain	ID=PRO_0000089079;Note=Actin-related protein 3
ACTR3	P61158	228	286	2	418	Chain	ID=PRO_0000089079;Note=Actin-related protein 3
ACTR3	P61158	286	317	2	418	Chain	ID=PRO_0000089079;Note=Actin-related protein 3
ACTR3	P61158	228	286	240	240	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACTR3	P61158	228	286	244	244	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACTR3	P61158	228	286	251	251	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACTR3	P61158	228	286	254	254	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ARVCF	O00192	880	898	1	962	Chain	ID=PRO_0000064294;Note=Armadillo repeat protein deleted in velo-cardio-facial syndrome
ASCC2	Q9H1I8	523	562	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	278	302	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	27	80	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	523	562	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	278	302	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	27	80	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	27	80	1	114	Alternative sequence	ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	27	80	1	114	Alternative sequence	ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	27	80	28	80	Alternative sequence	ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	27	80	28	80	Alternative sequence	ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	523	562	485	757	Alternative sequence	ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	523	562	485	757	Alternative sequence	ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	523	562	546	546	Natural variant	ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047
ASCC2	Q9H1I8	523	562	546	546	Natural variant	ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047
ASCC2	Q9H1I8	523	562	526	526	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC2	Q9H1I8	523	562	526	526	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASF1B	Q9NVP2	75	134	1	202	Chain	ID=PRO_0000284015;Note=Histone chaperone ASF1B
ASF1B	Q9NVP2	75	134	1	156	Region	Note=Interaction with histone H3;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASF1B	Q9NVP2	75	134	1	155	Region	Note=Interaction with CHAF1B
ASF1B	Q9NVP2	75	134	67	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ASF1B	Q9NVP2	75	134	81	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ASF1B	Q9NVP2	75	134	86	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ASF1B	Q9NVP2	75	134	90	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ASF1B	Q9NVP2	75	134	104	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ASF1B	Q9NVP2	75	134	120	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ASF1B	Q9NVP2	75	134	132	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BNX
ATP2B2	Q01814	712	772	1	1243	Chain	ID=PRO_0000046214;Note=Plasma membrane calcium-transporting ATPase 2
ATP2B2	Q01814	333	347	1	1243	Chain	ID=PRO_0000046214;Note=Plasma membrane calcium-transporting ATPase 2
ATP2B2	Q01814	302	313	1	1243	Chain	ID=PRO_0000046214;Note=Plasma membrane calcium-transporting ATPase 2
ATP2B2	Q01814	132	218	1	1243	Chain	ID=PRO_0000046214;Note=Plasma membrane calcium-transporting ATPase 2
ATP2B2	Q01814	132	218	116	152	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B2	Q01814	132	218	153	173	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B2	Q01814	333	347	174	390	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B2	Q01814	302	313	174	390	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B2	Q01814	132	218	174	390	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B2	Q01814	712	772	462	875	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B2	Q01814	333	347	303	347	Alternative sequence	ID=VSP_000384;Note=In isoform ZA and isoform ZB. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1427863,ECO:0000303|PubMed:8428366;Dbxref=PMID:1427863,PMID:8428366
ATP2B2	Q01814	302	313	303	347	Alternative sequence	ID=VSP_000384;Note=In isoform ZA and isoform ZB. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1427863,ECO:0000303|PubMed:8428366;Dbxref=PMID:1427863,PMID:8428366
ATP2B2	Q01814	333	347	304	334	Alternative sequence	ID=VSP_040837;Note=In isoform XA and isoform XB. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP2B2	Q01814	302	313	304	334	Alternative sequence	ID=VSP_040837;Note=In isoform XA and isoform XB. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP2B2	Q01814	333	347	334	347	Alternative sequence	ID=VSP_000385;Note=In isoform YA and isoform YB. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATG4D	Q86TL0	78	106	1	474	Chain	ID=PRO_0000215853;Note=Cysteine protease ATG4D
ATG4D	Q86TL0	374	414	1	474	Chain	ID=PRO_0000215853;Note=Cysteine protease ATG4D
ATG4D	Q86TL0	78	106	64	474	Chain	ID=PRO_0000423408;Note=Cysteine protease ATG4D%2C mitochondrial
ATG4D	Q86TL0	374	414	64	474	Chain	ID=PRO_0000423408;Note=Cysteine protease ATG4D%2C mitochondrial
ATG4D	Q86TL0	78	106	64	103	Region	Note=Cryptic mitochondrial signal peptide
ATG4D	Q86TL0	78	106	1	333	Alternative sequence	ID=VSP_056671;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATAD3A	Q9NVI7	94	176	2	634	Chain	ID=PRO_0000084799;Note=ATPase family AAA domain-containing protein 3A
ATAD3A	Q9NVI7	298	350	2	634	Chain	ID=PRO_0000084799;Note=ATPase family AAA domain-containing protein 3A
ATAD3A	Q9NVI7	94	176	2	294	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3A	Q9NVI7	298	350	295	312	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3A	Q9NVI7	298	350	313	634	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3A	Q9NVI7	298	350	338	353	Region	Note=S100B-binding
ATAD3A	Q9NVI7	94	176	139	267	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3A	Q9NVI7	94	176	95	142	Alternative sequence	ID=VSP_015636;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:20332122;Dbxref=PMID:14702039,PMID:15489334,PMID:20332122
ATAD3A	Q9NVI7	94	176	101	101	Natural variant	ID=VAR_055468;Note=S->N;Dbxref=dbSNP:rs1619896
ATAD3A	Q9NVI7	298	350	341	341	Mutagenesis	Note=Loss of S100B-binding%3B when associated with S-345. V->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20351179;Dbxref=PMID:20351179
ATAD3A	Q9NVI7	298	350	345	345	Mutagenesis	Note=Loss of S100B-binding%3B when associated with S-341. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20351179;Dbxref=PMID:20351179
ATAD3A	Q9NVI7	298	350	349	350	Mutagenesis	Note=Decrease in S100B-binding. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20351179;Dbxref=PMID:20351179
ATG13	O75143	106	152	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	199	231	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	263	300	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	410	449	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	106	152	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	199	231	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	263	300	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	410	449	1	517	Chain	ID=PRO_0000050767;Note=Autophagy-related protein 13
ATG13	O75143	106	152	127	134	Region	Note=Important for interaction with ATG101;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	127	134	Region	Note=Important for interaction with ATG101;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	410	449	444	447	Motif	Note=LIR;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24290141;Dbxref=PMID:24290141
ATG13	O75143	410	449	444	447	Motif	Note=LIR;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24290141;Dbxref=PMID:24290141
ATG13	O75143	263	300	263	299	Alternative sequence	ID=VSP_044504;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG13	O75143	263	300	263	299	Alternative sequence	ID=VSP_044504;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG13	O75143	263	300	265	301	Alternative sequence	ID=VSP_002431;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ATG13	O75143	263	300	265	301	Alternative sequence	ID=VSP_002431;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ATG13	O75143	410	449	428	442	Alternative sequence	ID=VSP_002432;Note=In isoform 3. HSDGSSGGSSGNTHD->PCSWPLPCLLSPSTV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG13	O75143	410	449	428	442	Alternative sequence	ID=VSP_002432;Note=In isoform 3. HSDGSSGGSSGNTHD->PCSWPLPCLLSPSTV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG13	O75143	410	449	443	517	Alternative sequence	ID=VSP_002433;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG13	O75143	410	449	443	517	Alternative sequence	ID=VSP_002433;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG13	O75143	106	152	127	127	Mutagenesis	Note=Abolishes interaction with ATG101%3B when associated with D-133. S->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	127	127	Mutagenesis	Note=Abolishes interaction with ATG101%3B when associated with D-133. S->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	131	131	Mutagenesis	Note=Decreases interaction with ATG101%3B when associated with D-134. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	131	131	Mutagenesis	Note=Decreases interaction with ATG101%3B when associated with D-134. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	133	133	Mutagenesis	Note=Abolishes interaction with ATG101%3B when associated with H-127. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	133	133	Mutagenesis	Note=Abolishes interaction with ATG101%3B when associated with H-127. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	134	134	Mutagenesis	Note=Decreases interaction with ATG101%3B when associated with D-131. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	106	152	134	134	Mutagenesis	Note=Decreases interaction with ATG101%3B when associated with D-131. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299944;Dbxref=PMID:26299944
ATG13	O75143	410	449	444	444	Mutagenesis	Note=Decreases interaction with MAP1LC3A. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24290141;Dbxref=PMID:24290141
ATG13	O75143	410	449	444	444	Mutagenesis	Note=Decreases interaction with MAP1LC3A. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24290141;Dbxref=PMID:24290141
ATG13	O75143	410	449	447	447	Mutagenesis	Note=Decreases interaction with MAP1LC3A. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24290141;Dbxref=PMID:24290141
ATG13	O75143	410	449	447	447	Mutagenesis	Note=Decreases interaction with MAP1LC3A. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24290141;Dbxref=PMID:24290141
ATG13	O75143	106	152	114	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	114	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	132	134	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	132	134	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	137	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	137	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	145	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ATG13	O75143	106	152	145	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C50
ARHGEF6	Q15052	568	610	1	776	Chain	ID=PRO_0000080917;Note=Rho guanine nucleotide exchange factor 6
ARHGEF6	Q15052	395	415	1	776	Chain	ID=PRO_0000080917;Note=Rho guanine nucleotide exchange factor 6
ARHGEF6	Q15052	55	83	1	776	Chain	ID=PRO_0000080917;Note=Rho guanine nucleotide exchange factor 6
ARHGEF6	Q15052	55	83	1	111	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
ARHGEF6	Q15052	395	415	241	421	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF6	Q15052	55	83	1	154	Alternative sequence	ID=VSP_015782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ARHGEF6	Q15052	55	83	63	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYR
ARHGEF19	Q8IW93	715	750	1	802	Chain	ID=PRO_0000285131;Note=Rho guanine nucleotide exchange factor 19
ARHGEF19	Q8IW93	636	688	1	802	Chain	ID=PRO_0000285131;Note=Rho guanine nucleotide exchange factor 19
ARHGEF19	Q8IW93	552	582	1	802	Chain	ID=PRO_0000285131;Note=Rho guanine nucleotide exchange factor 19
ARHGEF19	Q8IW93	552	582	376	560	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF19	Q8IW93	636	688	592	704	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF19	Q8IW93	715	750	715	776	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ARHGEF19	Q8IW93	715	750	484	783	Alternative sequence	ID=VSP_024827;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGEF19	Q8IW93	636	688	484	783	Alternative sequence	ID=VSP_024827;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGEF19	Q8IW93	552	582	484	783	Alternative sequence	ID=VSP_024827;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASB4	Q9Y574	62	162	1	426	Chain	ID=PRO_0000066928;Note=Ankyrin repeat and SOCS box protein 4
ASB4	Q9Y574	62	162	74	103	Repeat	Note=ANK 1
ASB4	Q9Y574	62	162	106	135	Repeat	Note=ANK 2
ASB4	Q9Y574	62	162	139	168	Repeat	Note=ANK 3
ASGR1	P07306	94	118	1	291	Chain	ID=PRO_0000046650;Note=Asialoglycoprotein receptor 1
ASGR1	P07306	23	62	1	291	Chain	ID=PRO_0000046650;Note=Asialoglycoprotein receptor 1
ASGR1	P07306	23	62	1	40	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASGR1	P07306	23	62	41	61	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASGR1	P07306	94	118	62	291	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASGR1	P07306	23	62	62	291	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASGR1	P07306	94	118	61	123	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ASGR1	P07306	23	62	61	123	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ASGR1	P07306	23	62	36	36	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8943311;Dbxref=PMID:8943311
ASGR1	P07306	23	62	24	63	Alternative sequence	ID=VSP_044480;Note=In isoform H1b. GPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20886072;Dbxref=PMID:20886072
ASCC3	Q8N3C0	1850	1925	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	1025	1084	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	579	634	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	423	465	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	579	634	486	669	Domain	Note=Helicase ATP-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ASCC3	Q8N3C0	1025	1084	978	1287	Domain	Note=SEC63 1
ASCC3	Q8N3C0	1850	1925	1812	2176	Domain	Note=SEC63 2
ASCC3	Q8N3C0	579	634	611	614	Motif	Note=DEVH box
ASCC3	Q8N3C0	1850	1925	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	1025	1084	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	579	634	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	423	465	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	1850	1925	732	2202	Alternative sequence	ID=VSP_042958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASCC3	Q8N3C0	1025	1084	732	2202	Alternative sequence	ID=VSP_042958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASCC3	Q8N3C0	1025	1084	1050	1050	Natural variant	ID=VAR_034860;Note=V->I;Dbxref=dbSNP:rs9497983
ASCC3	Q8N3C0	423	465	444	444	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC3	Q8N3C0	579	634	582	582	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASB9	Q96DX5	189	253	1	294	Chain	ID=PRO_0000066940;Note=Ankyrin repeat and SOCS box protein 9
ASB9	Q96DX5	189	253	166	195	Repeat	Note=ANK 5
ASB9	Q96DX5	189	253	198	227	Repeat	Note=ANK 6
ASB9	Q96DX5	189	253	240	294	Domain	Note=SOCS box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00194
ASB9	Q96DX5	189	253	192	192	Sequence conflict	Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASB9	Q96DX5	189	253	237	237	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASB9	Q96DX5	189	253	202	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9H
ASB9	Q96DX5	189	253	212	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9H
ASB9	Q96DX5	189	253	235	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9H
ASB9	Q96DX5	189	253	244	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9H
ATP13A3	Q9H7F0	1134	1161	1	1226	Chain	ID=PRO_0000046425;Note=Probable cation-transporting ATPase 13A3
ATP13A3	Q9H7F0	436	499	1	1226	Chain	ID=PRO_0000046425;Note=Probable cation-transporting ATPase 13A3
ATP13A3	Q9H7F0	160	186	1	1226	Chain	ID=PRO_0000046425;Note=Probable cation-transporting ATPase 13A3
ATP13A3	Q9H7F0	1134	1161	1	1226	Chain	ID=PRO_0000046425;Note=Probable cation-transporting ATPase 13A3
ATP13A3	Q9H7F0	436	499	1	1226	Chain	ID=PRO_0000046425;Note=Probable cation-transporting ATPase 13A3
ATP13A3	Q9H7F0	160	186	1	1226	Chain	ID=PRO_0000046425;Note=Probable cation-transporting ATPase 13A3
ATP13A3	Q9H7F0	436	499	449	469	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A3	Q9H7F0	436	499	449	469	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A3	Q9H7F0	1134	1161	1144	1164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A3	Q9H7F0	1134	1161	1144	1164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A3	Q9H7F0	436	499	498	498	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP13A3	Q9H7F0	436	499	498	498	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP13A3	Q9H7F0	160	186	1	277	Alternative sequence	ID=VSP_007314;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11867234;Dbxref=PMID:11867234
ATP13A3	Q9H7F0	160	186	1	277	Alternative sequence	ID=VSP_007314;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11867234;Dbxref=PMID:11867234
ATP13A3	Q9H7F0	1134	1161	979	1226	Alternative sequence	ID=VSP_007316;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11867234;Dbxref=PMID:11867234
ATP13A3	Q9H7F0	1134	1161	979	1226	Alternative sequence	ID=VSP_007316;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11867234;Dbxref=PMID:11867234
ATP10A	O60312	1191	1226	1	1499	Chain	ID=PRO_0000046379;Note=Probable phospholipid-transporting ATPase VA
ATP10A	O60312	1055	1097	1	1499	Chain	ID=PRO_0000046379;Note=Probable phospholipid-transporting ATPase VA
ATP10A	O60312	1055	1097	385	1087	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10A	O60312	1055	1097	1088	1108	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10A	O60312	1191	1226	1171	1192	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10A	O60312	1191	1226	1193	1199	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10A	O60312	1191	1226	1200	1222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10A	O60312	1191	1226	1223	1228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10A	O60312	1191	1226	156	1499	Alternative sequence	ID=VSP_056605;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATP10A	O60312	1055	1097	156	1499	Alternative sequence	ID=VSP_056605;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATP10A	O60312	1191	1226	1198	1198	Natural variant	ID=VAR_048382;Note=V->M;Dbxref=dbSNP:rs2076746
ATP13A4	Q4VNC1	1099	1126	1	1196	Chain	ID=PRO_0000318675;Note=Probable cation-transporting ATPase 13A4
ATP13A4	Q4VNC1	558	587	1	1196	Chain	ID=PRO_0000318675;Note=Probable cation-transporting ATPase 13A4
ATP13A4	Q4VNC1	424	487	1	1196	Chain	ID=PRO_0000318675;Note=Probable cation-transporting ATPase 13A4
ATP13A4	Q4VNC1	151	177	1	1196	Chain	ID=PRO_0000318675;Note=Probable cation-transporting ATPase 13A4
ATP13A4	Q4VNC1	78	127	1	1196	Chain	ID=PRO_0000318675;Note=Probable cation-transporting ATPase 13A4
ATP13A4	Q4VNC1	151	177	53	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	78	127	53	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	424	487	422	436	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	424	487	437	457	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	558	587	458	900	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	424	487	458	900	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	1099	1126	1092	1109	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	1099	1126	1110	1130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A4	Q4VNC1	424	487	486	486	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP13A4	Q4VNC1	558	587	1	984	Alternative sequence	ID=VSP_031258;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ATP13A4	Q4VNC1	424	487	1	984	Alternative sequence	ID=VSP_031258;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ATP13A4	Q4VNC1	151	177	1	984	Alternative sequence	ID=VSP_031258;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ATP13A4	Q4VNC1	78	127	1	984	Alternative sequence	ID=VSP_031258;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ATP13A4	Q4VNC1	558	587	559	576	Alternative sequence	ID=VSP_031259;Note=In isoform 3. EMAFSGDDFHIKGVPAHA->VSLCSSENLRSFFNARAT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ATP13A4	Q4VNC1	1099	1126	577	1196	Alternative sequence	ID=VSP_031260;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ATP13A4	Q4VNC1	558	587	577	1196	Alternative sequence	ID=VSP_031260;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ATP13A4	Q4VNC1	1099	1126	841	1196	Alternative sequence	ID=VSP_031261;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ATP11A	P98196	54	84	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	111	147	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	225	241	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	889	909	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	54	84	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	111	147	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	225	241	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	889	909	1	1134	Chain	ID=PRO_0000046369;Note=Probable phospholipid-transporting ATPase IH
ATP11A	P98196	54	84	1	61	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	54	84	1	61	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	54	84	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	54	84	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	54	84	83	88	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	54	84	83	88	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	111	147	111	296	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	225	241	111	296	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	111	147	111	296	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	225	241	111	296	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	889	909	882	902	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	889	909	882	902	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	889	909	903	914	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11A	P98196	889	909	903	914	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	484	547	1	1192	Chain	ID=PRO_0000046368;Note=Probable phospholipid-transporting ATPase IM
ATP8B4	Q8TF62	196	249	1	1192	Chain	ID=PRO_0000046368;Note=Probable phospholipid-transporting ATPase IM
ATP8B4	Q8TF62	29	67	1	1192	Chain	ID=PRO_0000046368;Note=Probable phospholipid-transporting ATPase IM
ATP8B4	Q8TF62	484	547	1	1192	Chain	ID=PRO_0000046368;Note=Probable phospholipid-transporting ATPase IM
ATP8B4	Q8TF62	196	249	1	1192	Chain	ID=PRO_0000046368;Note=Probable phospholipid-transporting ATPase IM
ATP8B4	Q8TF62	29	67	1	1192	Chain	ID=PRO_0000046368;Note=Probable phospholipid-transporting ATPase IM
ATP8B4	Q8TF62	29	67	1	44	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	29	67	1	44	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	29	67	45	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	29	67	45	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	29	67	67	72	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	29	67	67	72	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	196	249	93	276	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	196	249	93	276	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	484	547	350	871	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	484	547	350	871	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B4	Q8TF62	196	249	225	225	Natural variant	ID=VAR_046962;Note=N->S;Dbxref=dbSNP:rs16963151
ATP8B4	Q8TF62	196	249	225	225	Natural variant	ID=VAR_046962;Note=N->S;Dbxref=dbSNP:rs16963151
ASB1	Q9Y576	64	164	1	335	Chain	ID=PRO_0000066923;Note=Ankyrin repeat and SOCS box protein 1
ASB1	Q9Y576	64	164	36	68	Repeat	Note=ANK 1
ASB1	Q9Y576	64	164	77	106	Repeat	Note=ANK 2
ASB1	Q9Y576	64	164	110	139	Repeat	Note=ANK 3
ASB1	Q9Y576	64	164	143	172	Repeat	Note=ANK 4
ASB6	Q9NWX5	170	199	1	421	Chain	ID=PRO_0000066933;Note=Ankyrin repeat and SOCS box protein 6
ASB6	Q9NWX5	170	199	170	205	Repeat	Note=ANK 4
ASB6	Q9NWX5	170	199	135	421	Alternative sequence	ID=VSP_042006;Note=In isoform 2. IHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI->EKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPASSSCLVRPWEGTKRRPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASIC1	P78348	505	540	1	528	Chain	ID=PRO_0000181294;Note=Acid-sensing ion channel 1
ASIC1	P78348	505	540	455	528	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASXL3	Q9C0F0	198	238	1	2248	Chain	ID=PRO_0000320670;Note=Putative Polycomb group protein ASXL3
ATP13A1	Q9HD20	1120	1168	2	1204	Chain	ID=PRO_0000046421;Note=Manganese-transporting ATPase 13A1
ATP13A1	Q9HD20	700	742	2	1204	Chain	ID=PRO_0000046421;Note=Manganese-transporting ATPase 13A1
ATP13A1	Q9HD20	663	700	2	1204	Chain	ID=PRO_0000046421;Note=Manganese-transporting ATPase 13A1
ATP13A1	Q9HD20	700	742	465	989	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A1	Q9HD20	663	700	465	989	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A1	Q9HD20	1120	1168	1118	1132	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A1	Q9HD20	1120	1168	1133	1153	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A1	Q9HD20	1120	1168	1154	1166	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A1	Q9HD20	1120	1168	1167	1187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A1	Q9HD20	700	742	1	860	Alternative sequence	ID=VSP_000433;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP13A1	Q9HD20	663	700	1	860	Alternative sequence	ID=VSP_000433;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP13A1	Q9HD20	1120	1168	1150	1150	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATXN7L1	Q9ULK2	83	118	1	861	Chain	ID=PRO_0000064718;Note=Ataxin-7-like protein 1
ATXN7L1	Q9ULK2	83	118	1	124	Alternative sequence	ID=VSP_041344;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN7L2	Q5T6C5	42	64	1	722	Chain	ID=PRO_0000278300;Note=Ataxin-7-like protein 2
ATXN7L2	Q5T6C5	64	99	1	722	Chain	ID=PRO_0000278300;Note=Ataxin-7-like protein 2
ATP13A2	Q9NQ11	804	843	1	1180	Chain	ID=PRO_0000046423;Note=Cation-transporting ATPase 13A2
ATP13A2	Q9NQ11	514	583	1	1180	Chain	ID=PRO_0000046423;Note=Cation-transporting ATPase 13A2
ATP13A2	Q9NQ11	451	514	1	1180	Chain	ID=PRO_0000046423;Note=Cation-transporting ATPase 13A2
ATP13A2	Q9NQ11	398	435	1	1180	Chain	ID=PRO_0000046423;Note=Cation-transporting ATPase 13A2
ATP13A2	Q9NQ11	302	346	1	1180	Chain	ID=PRO_0000046423;Note=Cation-transporting ATPase 13A2
ATP13A2	Q9NQ11	398	435	277	425	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	302	346	277	425	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	398	435	426	445	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	451	514	446	459	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	451	514	460	480	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	804	843	481	932	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	514	583	481	932	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	451	514	481	932	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP13A2	Q9NQ11	451	514	513	513	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP13A2	Q9NQ11	804	843	805	843	Alternative sequence	ID=VSP_007311;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.8;Dbxref=PMID:15489334
ATP13A2	Q9NQ11	451	514	504	504	Natural variant	ID=VAR_058455;Note=In KRS%3B decreased protein stability%3B increased degradation by proteasome%3B novel location to endoplasmic reticulum%3B loss of lysosomal membrane location. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17485642,ECO:0000269|PubMed:22768177;Dbxref=dbSNP:rs121918227,PMID:17485642,PMID:22768177
ATP13A2	Q9NQ11	514	583	517	517	Natural variant	ID=VAR_078055;Note=In SPG78%3B no effect on protein stability%3B loss of autophosphorylation%3B loss of lysosomal location. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28137957;Dbxref=dbSNP:rs1057519291,PMID:28137957
ATP13A2	Q9NQ11	514	583	522	522	Natural variant	ID=VAR_078056;Note=In KRS%3B unknown pathological significance. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22296644;Dbxref=PMID:22296644
ATP13A2	Q9NQ11	514	583	533	533	Natural variant	ID=VAR_058456;Note=In a patient with early onset Parkinson disease and KRS%3B decreased ATPase activity%3B no effect on autophosphorylation%3B no effect on stability%3B no effect on location. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17485642,ECO:0000269|PubMed:22768177,ECO:0000269|PubMed:28137957;Dbxref=PMID:17485642,PMID:22768177,PMID:28137957
ATP13A2	Q9NQ11	514	583	578	578	Natural variant	ID=VAR_058457;Note=V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19085912;Dbxref=dbSNP:rs56186751,PMID:19085912
ATP13A2	Q9NQ11	451	514	513	513	Mutagenesis	Note=Loss of ATPase function. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28137957;Dbxref=PMID:28137957
ATP13A2	Q9NQ11	302	346	322	322	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP1B4	Q9UN42	109	152	1	357	Chain	ID=PRO_0000219122;Note=Protein ATP1B4
ATP1B4	Q9UN42	109	152	1	110	Topological domain	Note=Nuclear;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B4	Q9UN42	109	152	111	131	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B4	Q9UN42	109	152	132	357	Topological domain	Note=Perinuclear space;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B4	Q9UN42	109	152	107	110	Alternative sequence	ID=VSP_000351;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10456317;Dbxref=PMID:10456317
ATP1A2	P50993	59	127	6	1020	Chain	ID=PRO_0000002504;Note=Sodium/potassium-transporting ATPase subunit alpha-2
ATP1A2	P50993	59	127	6	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A2	P50993	59	127	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A2	P50993	59	127	107	129	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A2	P50993	59	127	80	82	Region	Note=Interaction with phosphoinositide-3 kinase;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATL1	Q8WXF7	191	210	1	558	Chain	ID=PRO_0000190971;Note=Atlastin-1
ATL1	Q8WXF7	373	517	1	558	Chain	ID=PRO_0000190971;Note=Atlastin-1
ATL1	Q8WXF7	191	210	1	449	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14506257;Dbxref=PMID:14506257
ATL1	Q8WXF7	373	517	1	449	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14506257;Dbxref=PMID:14506257
ATL1	Q8WXF7	373	517	450	470	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL1	Q8WXF7	373	517	471	471	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL1	Q8WXF7	373	517	472	492	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL1	Q8WXF7	373	517	493	558	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14506257;Dbxref=PMID:14506257
ATL1	Q8WXF7	191	210	64	309	Domain	Note=GB1/RHD3-type G
ATL1	Q8WXF7	373	517	448	558	Region	Note=Sufficient for membrane association
ATL1	Q8WXF7	373	517	412	439	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ATL1	Q8WXF7	373	517	395	395	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6DD88
ATL1	Q8WXF7	191	210	193	193	Natural variant	ID=VAR_058964;Note=F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17850683,PMID:15489334
ATL1	Q8WXF7	191	210	196	196	Natural variant	ID=VAR_067656;Note=In a patient with hereditary spastic paraplegia%3B unknown pathological significance%3B no effect on homodimerization and GTPase activity. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20718791,ECO:0000269|PubMed:21220294;Dbxref=PMID:20718791,PMID:21220294
ATL1	Q8WXF7	373	517	408	408	Natural variant	ID=VAR_065511;Note=In SPG3. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12939451;Dbxref=dbSNP:rs28939094,PMID:12939451
ATL1	Q8WXF7	373	517	413	413	Natural variant	ID=VAR_067658;Note=In SPG3. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
ATL1	Q8WXF7	373	517	415	415	Natural variant	ID=VAR_071708;Note=In SPG3. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23483706;Dbxref=dbSNP:rs397514712,PMID:23483706
ATL1	Q8WXF7	373	517	415	415	Natural variant	ID=VAR_065512;Note=In SPG3. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15184642,ECO:0000269|PubMed:20932283,ECO:0000269|PubMed:23483706;Dbxref=dbSNP:rs119476050,PMID:15184642,PMID:20932283,PMID:23483706
ATL1	Q8WXF7	373	517	416	416	Natural variant	ID=VAR_071709;Note=In SPG3. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21336785;Dbxref=dbSNP:rs387906941,PMID:21336785
ATL1	Q8WXF7	373	517	436	436	Natural variant	ID=VAR_065513;Note=In SPG3%3B does not affect GTPase activity%3B does not affect interaction with SPAST%3B patients' lymphoblasts show decreased protein levels but normal levels of mRNA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17427918;Dbxref=PMID:17427918
ATL1	Q8WXF7	373	517	440	440	Natural variant	ID=VAR_067659;Note=In SPG3. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
ATL1	Q8WXF7	373	517	495	495	Natural variant	ID=VAR_067660;Note=In SPG3%3B affects endoplasmic reticulum and Golgi morphology. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17321752,ECO:0000269|PubMed:20718791,ECO:0000269|PubMed:20932283;Dbxref=dbSNP:rs864622269,PMID:17321752,PMID:20718791,PMID:20932283
ATL1	Q8WXF7	191	210	191	191	Mutagenesis	Note=Abolishes homodimerization. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220294;Dbxref=PMID:21220294
ATL1	Q8WXF7	373	517	398	398	Mutagenesis	Note=Affects endoplasmic reticulum and Golgi morphology. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17321752;Dbxref=PMID:17321752
ATL1	Q8WXF7	191	210	184	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9F
ATL1	Q8WXF7	191	210	208	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9F
ATL1	Q8WXF7	373	517	347	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9F
ATL1	Q8WXF7	373	517	377	380	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q5D
ATL1	Q8WXF7	373	517	384	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9F
ATL1	Q8WXF7	373	517	410	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9F
ATL1	Q8WXF7	373	517	443	446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B9F
AQP3	Q92482	78	124	1	292	Chain	ID=PRO_0000063943;Note=Aquaporin-3
AQP3	Q92482	78	124	75	109	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP3	Q92482	78	124	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP3	Q92482	78	124	83	85	Motif	Note=NPA 1
ARF3	P61204	49	86	2	181	Chain	ID=PRO_0000207386;Note=ADP-ribosylation factor 3
ARF3	P61204	49	86	2	181	Chain	ID=PRO_0000207386;Note=ADP-ribosylation factor 3
ARF3	P61204	49	86	67	71	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARF3	P61204	49	86	67	71	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARF3	P61204	49	86	50	86	Alternative sequence	ID=VSP_056935;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARF3	P61204	49	86	50	86	Alternative sequence	ID=VSP_056935;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARNT	P27540	465	501	2	789	Chain	ID=PRO_0000127118;Note=Aryl hydrocarbon receptor nuclear translocator
ARNT	P27540	76	90	2	789	Chain	ID=PRO_0000127118;Note=Aryl hydrocarbon receptor nuclear translocator
ARNT	P27540	46	60	2	789	Chain	ID=PRO_0000127118;Note=Aryl hydrocarbon receptor nuclear translocator
ARNT	P27540	76	90	89	142	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
ARNT	P27540	465	501	424	467	Domain	Note=PAC
ARNT	P27540	76	90	88	128	Region	Note=DNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28396409;Dbxref=PMID:28396409
ARNT	P27540	76	90	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ARNT	P27540	46	60	58	58	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ARNT	P27540	76	90	77	91	Alternative sequence	ID=VSP_002092;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1852076;Dbxref=PMID:1852076
ARSF	P54793	94	135	23	590	Chain	ID=PRO_0000033427;Note=Arylsulfatase F
ARSF	P54793	94	135	23	590	Chain	ID=PRO_0000033427;Note=Arylsulfatase F
ARSF	P54793	94	135	117	117	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ARSF	P54793	94	135	117	117	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ARSG	Q96EG1	135	151	17	525	Chain	ID=PRO_0000042215;Note=Arylsulfatase G
ARSG	Q96EG1	300	327	17	525	Chain	ID=PRO_0000042215;Note=Arylsulfatase G
ARSG	Q96EG1	135	151	139	139	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
ARSG	Q96EG1	300	327	302	302	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSG	Q96EG1	300	327	303	303	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSG	Q96EG1	135	151	137	137	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSG	Q96EG1	300	327	326	326	Natural variant	ID=VAR_074038;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825126;Dbxref=dbSNP:rs144503106,PMID:25825126
ASGR2	P07307	141	170	1	311	Chain	ID=PRO_0000046654;Note=Asialoglycoprotein receptor 2
ASGR2	P07307	41	85	1	311	Chain	ID=PRO_0000046654;Note=Asialoglycoprotein receptor 2
ASGR2	P07307	41	85	1	58	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASGR2	P07307	41	85	59	79	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASGR2	P07307	141	170	80	311	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASGR2	P07307	41	85	80	311	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASGR2	P07307	41	85	54	54	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASGR2	P07307	141	170	170	170	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ASGR2	P07307	41	85	24	42	Alternative sequence	ID=VSP_003060;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASGR2	P07307	41	85	82	86	Alternative sequence	ID=VSP_003061;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASGR2	P07307	41	85	85	85	Natural variant	ID=VAR_068747;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1371982,ECO:0000269|PubMed:3863106,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2304978,PMID:1371982,PMID:3863106
ASB7	Q9H672	70	272	1	318	Chain	ID=PRO_0000066935;Note=Ankyrin repeat and SOCS box protein 7
ASB7	Q9H672	70	272	46	75	Repeat	Note=ANK 2
ASB7	Q9H672	70	272	80	109	Repeat	Note=ANK 3
ASB7	Q9H672	70	272	116	145	Repeat	Note=ANK 4
ASB7	Q9H672	70	272	149	178	Repeat	Note=ANK 5
ASB7	Q9H672	70	272	180	208	Repeat	Note=ANK 6
ASB7	Q9H672	70	272	213	242	Repeat	Note=ANK 7
ASB7	Q9H672	70	272	265	318	Domain	Note=SOCS box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00194
ASB7	Q9H672	70	272	162	162	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACTR3B	Q9P1U1	144	180	1	418	Chain	ID=PRO_0000342358;Note=Actin-related protein 3B
ACTR3B	Q9P1U1	317	359	1	418	Chain	ID=PRO_0000342358;Note=Actin-related protein 3B
ACTR3B	Q9P1U1	359	387	1	418	Chain	ID=PRO_0000342358;Note=Actin-related protein 3B
ACTR3B	Q9P1U1	317	359	318	387	Alternative sequence	ID=VSP_041474;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACTR3B	Q9P1U1	359	387	318	387	Alternative sequence	ID=VSP_041474;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASB15	Q8WXK1	97	150	1	588	Chain	ID=PRO_0000066954;Note=Ankyrin repeat and SOCS box protein 15
ASB15	Q8WXK1	97	150	1	588	Chain	ID=PRO_0000066954;Note=Ankyrin repeat and SOCS box protein 15
ASB15	Q8WXK1	97	150	1	588	Chain	ID=PRO_0000066954;Note=Ankyrin repeat and SOCS box protein 15
ASB15	Q8WXK1	97	150	1	588	Chain	ID=PRO_0000066954;Note=Ankyrin repeat and SOCS box protein 15
ASB15	Q8WXK1	97	150	110	142	Repeat	Note=ANK 1
ASB15	Q8WXK1	97	150	110	142	Repeat	Note=ANK 1
ASB15	Q8WXK1	97	150	110	142	Repeat	Note=ANK 1
ASB15	Q8WXK1	97	150	110	142	Repeat	Note=ANK 1
ASB15	Q8WXK1	97	150	143	174	Repeat	Note=ANK 2
ASB15	Q8WXK1	97	150	143	174	Repeat	Note=ANK 2
ASB15	Q8WXK1	97	150	143	174	Repeat	Note=ANK 2
ASB15	Q8WXK1	97	150	143	174	Repeat	Note=ANK 2
ASCC1	Q8N9N2	237	276	1	400	Chain	ID=PRO_0000050100;Note=Activating signal cointegrator 1 complex subunit 1
ASCC1	Q8N9N2	71	98	1	400	Chain	ID=PRO_0000050100;Note=Activating signal cointegrator 1 complex subunit 1
ASCC1	Q8N9N2	237	276	1	400	Chain	ID=PRO_0000050100;Note=Activating signal cointegrator 1 complex subunit 1
ASCC1	Q8N9N2	71	98	1	400	Chain	ID=PRO_0000050100;Note=Activating signal cointegrator 1 complex subunit 1
ASCC1	Q8N9N2	71	98	86	148	Domain	Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
ASCC1	Q8N9N2	71	98	86	148	Domain	Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
ASCC1	Q8N9N2	71	98	71	99	Alternative sequence	ID=VSP_011007;Note=In isoform 2. NLIHLNTSNDCGFQKITLDCQNIYTWKSR->K;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10810093,ECO:0000303|PubMed:12077347,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10810093,PMID:12077347,PMID:14702039,PMID:15489334
ASCC1	Q8N9N2	71	98	71	99	Alternative sequence	ID=VSP_011007;Note=In isoform 2. NLIHLNTSNDCGFQKITLDCQNIYTWKSR->K;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10810093,ECO:0000303|PubMed:12077347,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10810093,PMID:12077347,PMID:14702039,PMID:15489334
ASCC1	Q8N9N2	237	276	240	243	Sequence conflict	Note=SGGK->PGR;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	240	243	Sequence conflict	Note=SGGK->PGR;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	240	243	Sequence conflict	Note=SGGK->PGR;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	240	243	Sequence conflict	Note=SGGK->PGR;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	250	250	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	250	250	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	250	250	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC1	Q8N9N2	237	276	250	250	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARRDC1	Q8N5I2	76	93	1	433	Chain	ID=PRO_0000244345;Note=Arrestin domain-containing protein 1
ARRDC1	Q8N5I2	145	206	1	433	Chain	ID=PRO_0000244345;Note=Arrestin domain-containing protein 1
ARRDC1	Q8N5I2	76	93	88	88	Mutagenesis	Note=Loss of localization to the cell membrane and extracellular vesicles. Localizes to the cytoplasm. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22315426;Dbxref=PMID:22315426
ARRDC1	Q8N5I2	145	206	180	180	Mutagenesis	Note=Decreased localization to the cell membrane and extracellular vesicles. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22315426;Dbxref=PMID:22315426
ARRDC1	Q8N5I2	145	206	191	191	Mutagenesis	Note=Decreased localization to the cell membrane and extracellular vesicles. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22315426;Dbxref=PMID:22315426
ATP8A1	Q9Y2Q0	1005	1041	1	1164	Chain	ID=PRO_0000046360;Note=Phospholipid-transporting ATPase IA
ATP8A1	Q9Y2Q0	836	873	1	1164	Chain	ID=PRO_0000046360;Note=Phospholipid-transporting ATPase IA
ATP8A1	Q9Y2Q0	432	446	1	1164	Chain	ID=PRO_0000046360;Note=Phospholipid-transporting ATPase IA
ATP8A1	Q9Y2Q0	836	873	367	857	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8A1	Q9Y2Q0	432	446	367	857	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8A1	Q9Y2Q0	836	873	858	878	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8A1	Q9Y2Q0	1005	1041	1000	1005	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8A1	Q9Y2Q0	1005	1041	1006	1026	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8A1	Q9Y2Q0	1005	1041	1027	1044	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8A1	Q9Y2Q0	432	446	443	443	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70704
ATP8A1	Q9Y2Q0	432	446	433	447	Alternative sequence	ID=VSP_000431;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10198212,ECO:0000303|PubMed:15489334;Dbxref=PMID:10198212,PMID:15489334
ATAD3B	Q5T9A4	250	302	2	648	Chain	ID=PRO_0000084800;Note=ATPase family AAA domain-containing protein 3B
ATAD3B	Q5T9A4	302	321	2	648	Chain	ID=PRO_0000084800;Note=ATPase family AAA domain-containing protein 3B
ATAD3B	Q5T9A4	250	302	247	264	Intramembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3B	Q5T9A4	250	302	265	648	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3B	Q5T9A4	302	321	265	648	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATAD3B	Q5T9A4	250	302	252	284	Alternative sequence	ID=VSP_015641;Note=In isoform 2. AGLTLLAVGVYSAKNATAVTGRFIEARLGKPSL->NIFIKQGWQVAERQHVGASWSPRSCPCRLCTAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATAD3B	Q5T9A4	250	302	285	648	Alternative sequence	ID=VSP_015642;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATAD3B	Q5T9A4	302	321	285	648	Alternative sequence	ID=VSP_015642;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP11B	Q9Y2G3	48	78	1	1177	Chain	ID=PRO_0000046371;Note=Probable phospholipid-transporting ATPase IF
ATP11B	Q9Y2G3	219	234	1	1177	Chain	ID=PRO_0000046371;Note=Probable phospholipid-transporting ATPase IF
ATP11B	Q9Y2G3	334	400	1	1177	Chain	ID=PRO_0000046371;Note=Probable phospholipid-transporting ATPase IF
ATP11B	Q9Y2G3	885	905	1	1177	Chain	ID=PRO_0000046371;Note=Probable phospholipid-transporting ATPase IF
ATP11B	Q9Y2G3	48	78	1	55	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	48	78	56	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	48	78	78	82	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	219	234	105	289	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	334	400	312	341	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	334	400	342	359	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	334	400	360	876	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	885	905	877	898	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP11B	Q9Y2G3	885	905	899	910	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATG12	O94817	100	121	1	140	Chain	ID=PRO_0000212471;Note=Ubiquitin-like protein ATG12
ATG12	O94817	100	121	75	140	Alternative sequence	ID=VSP_018105;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG12	O94817	100	121	108	108	Mutagenesis	Note=Impairs ATG12 stability. F->A%2CD%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23202584;Dbxref=PMID:23202584
ATG12	O94817	100	121	113	113	Mutagenesis	Note=Impairs E3 activity of the ATG12-ATG5 conjugate. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23202584;Dbxref=PMID:23202584
ATG12	O94817	100	121	101	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NAW
ATG12	O94817	100	121	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NAW
ATG12	O94817	100	121	116	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NAW
ACTR10	Q9NZ32	114	150	1	417	Chain	ID=PRO_0000089131;Note=Actin-related protein 10
ACTR10	Q9NZ32	199	211	1	417	Chain	ID=PRO_0000089131;Note=Actin-related protein 10
ASAH1	Q13510	127	152	22	142	Chain	ID=PRO_0000002312;Note=Acid ceramidase subunit alpha
ASAH1	Q13510	72	101	22	142	Chain	ID=PRO_0000002312;Note=Acid ceramidase subunit alpha
ASAH1	Q13510	127	152	143	395	Chain	ID=PRO_0000002313;Note=Acid ceramidase subunit beta
ASAH1	Q13510	72	101	73	101	Alternative sequence	ID=VSP_046285;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASAH1	Q13510	72	101	72	72	Natural variant	ID=VAR_008860;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10993717,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8955159,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1071645,PMID:10993717,PMID:15489334,PMID:8955159
ASAH1	Q13510	72	101	88	88	Natural variant	ID=VAR_057980;Note=V->M;Dbxref=dbSNP:rs1071645
ASAH1	Q13510	72	101	93	93	Natural variant	ID=VAR_008861;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10993717,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8955159,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1049874,PMID:10993717,PMID:15489334,PMID:8955159
ASAH1	Q13510	72	101	96	96	Natural variant	ID=VAR_021580;Note=In FRBRL. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12638942;Dbxref=PMID:12638942
ASAH1	Q13510	72	101	97	97	Natural variant	ID=VAR_021581;Note=In FRBRL. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12638942;Dbxref=PMID:12638942
ASAH1	Q13510	72	101	97	97	Natural variant	ID=VAR_071994;Note=In FRBRL. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21893389;Dbxref=PMID:21893389
ASAH1	Q13510	127	152	138	138	Natural variant	ID=VAR_021582;Note=In FRBRL. E->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10610716,ECO:0000269|PubMed:10993717;Dbxref=dbSNP:rs137853594,PMID:10610716,PMID:10993717
ASAH1	Q13510	127	152	152	152	Natural variant	ID=VAR_072247;Note=In SMAPME%3B results in reduced activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24164096;Dbxref=dbSNP:rs200455852,PMID:24164096
ASAH1	Q13510	127	152	142	142	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMPDL3B	Q92485	124	172	19	455	Chain	ID=PRO_0000002331;Note=Acid sphingomyelinase-like phosphodiesterase 3b
SMPDL3B	Q92485	124	172	134	134	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92484
SMPDL3B	Q92485	124	172	164	164	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMPDL3B	Q92485	124	172	135	135	Mutagenesis	Note=Reduced phosphodiesterase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26095358;Dbxref=PMID:26095358
ASS1	P00966	35	58	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	58	121	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	121	140	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	140	165	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	279	323	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	376	397	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	35	58	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	58	121	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	121	140	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	140	165	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	279	323	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	376	397	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	35	58	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	58	121	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	121	140	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	140	165	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	279	323	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	376	397	1	412	Chain	ID=PRO_0000148554;Note=Argininosuccinate synthase
ASS1	P00966	58	121	115	123	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	121	140	115	123	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	58	121	115	123	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	121	140	115	123	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	58	121	115	123	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	121	140	115	123	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	35	58	36	36	Binding site	Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	35	58	36	36	Binding site	Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	35	58	36	36	Binding site	Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASS1	P00966	58	121	87	87	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	87	87	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	87	87	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	92	92	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	92	92	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	92	92	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	119	119	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	119	119	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	119	119	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	123	123	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	123	123	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	123	123	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	123	123	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	123	123	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	123	123	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	124	124	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	124	124	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	124	124	Binding site	Note=Aspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	127	127	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	127	127	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	121	140	127	127	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	279	323	282	282	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	279	323	282	282	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	279	323	282	282	Binding site	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18323623;Dbxref=PMID:18323623
ASS1	P00966	58	121	87	87	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09034
ASS1	P00966	58	121	87	87	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09034
ASS1	P00966	58	121	87	87	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09034
ASS1	P00966	58	121	112	112	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16460
ASS1	P00966	58	121	112	112	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16460
ASS1	P00966	58	121	112	112	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16460
ASS1	P00966	58	121	113	113	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ASS1	P00966	58	121	113	113	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ASS1	P00966	58	121	113	113	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ASS1	P00966	140	165	165	165	Modified residue	Note=N6-acetyllysine%3B by CLOCK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985504;Dbxref=PMID:28985504
ASS1	P00966	140	165	165	165	Modified residue	Note=N6-acetyllysine%3B by CLOCK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985504;Dbxref=PMID:28985504
ASS1	P00966	140	165	165	165	Modified residue	Note=N6-acetyllysine%3B by CLOCK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985504;Dbxref=PMID:28985504
ASS1	P00966	35	58	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	35	58	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	35	58	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	27	412	Natural variant	ID=VAR_078387;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	35	58	40	40	Natural variant	ID=VAR_058337;Note=In CTLN1. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14680976;Dbxref=PMID:14680976
ASS1	P00966	35	58	40	40	Natural variant	ID=VAR_058337;Note=In CTLN1. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14680976;Dbxref=PMID:14680976
ASS1	P00966	35	58	40	40	Natural variant	ID=VAR_058337;Note=In CTLN1. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14680976;Dbxref=PMID:14680976
ASS1	P00966	58	121	64	64	Natural variant	ID=VAR_078388;Note=In CTLN1%3B unknown pathological significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs556297791,PMID:28111830
ASS1	P00966	58	121	64	64	Natural variant	ID=VAR_078388;Note=In CTLN1%3B unknown pathological significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs556297791,PMID:28111830
ASS1	P00966	58	121	64	64	Natural variant	ID=VAR_078388;Note=In CTLN1%3B unknown pathological significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs556297791,PMID:28111830
ASS1	P00966	58	121	69	69	Natural variant	ID=VAR_016013;Note=In CTLN1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11708871;Dbxref=dbSNP:rs771594651,PMID:11708871
ASS1	P00966	58	121	69	69	Natural variant	ID=VAR_016013;Note=In CTLN1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11708871;Dbxref=dbSNP:rs771594651,PMID:11708871
ASS1	P00966	58	121	69	69	Natural variant	ID=VAR_016013;Note=In CTLN1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11708871;Dbxref=dbSNP:rs771594651,PMID:11708871
ASS1	P00966	58	121	79	79	Natural variant	ID=VAR_058338;Note=In CTLN1. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	58	121	79	79	Natural variant	ID=VAR_058338;Note=In CTLN1. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	58	121	79	79	Natural variant	ID=VAR_058338;Note=In CTLN1. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	58	121	86	86	Natural variant	ID=VAR_000683;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1943692;Dbxref=dbSNP:rs121908644,PMID:1943692
ASS1	P00966	58	121	86	86	Natural variant	ID=VAR_000683;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1943692;Dbxref=dbSNP:rs121908644,PMID:1943692
ASS1	P00966	58	121	86	86	Natural variant	ID=VAR_000683;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1943692;Dbxref=dbSNP:rs121908644,PMID:1943692
ASS1	P00966	58	121	86	86	Natural variant	ID=VAR_015892;Note=In CTLN1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs575001023,PMID:12815590
ASS1	P00966	58	121	86	86	Natural variant	ID=VAR_015892;Note=In CTLN1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs575001023,PMID:12815590
ASS1	P00966	58	121	86	86	Natural variant	ID=VAR_015892;Note=In CTLN1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs575001023,PMID:12815590
ASS1	P00966	58	121	91	91	Natural variant	ID=VAR_078389;Note=In CTLN1%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs769018733,PMID:24889030,PMID:27287393
ASS1	P00966	58	121	91	91	Natural variant	ID=VAR_078389;Note=In CTLN1%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs769018733,PMID:24889030,PMID:27287393
ASS1	P00966	58	121	91	91	Natural variant	ID=VAR_078389;Note=In CTLN1%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs769018733,PMID:24889030,PMID:27287393
ASS1	P00966	58	121	95	95	Natural variant	ID=VAR_015893;Note=In CTLN1%3B increased thermal stability%3B loss of argininosuccinate synthase activity. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=PMID:12815590,PMID:27287393
ASS1	P00966	58	121	95	95	Natural variant	ID=VAR_015893;Note=In CTLN1%3B increased thermal stability%3B loss of argininosuccinate synthase activity. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=PMID:12815590,PMID:27287393
ASS1	P00966	58	121	95	95	Natural variant	ID=VAR_015893;Note=In CTLN1%3B increased thermal stability%3B loss of argininosuccinate synthase activity. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=PMID:12815590,PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_058339;Note=In CTLN1%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. P->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=PMID:19006241,PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_058339;Note=In CTLN1%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. P->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=PMID:19006241,PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_058339;Note=In CTLN1%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. P->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=PMID:19006241,PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_078390;Note=In CTLN1%3B decreased thermal stability%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B loss of argininosuccinate synthase activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27287393;Dbxref=PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_078390;Note=In CTLN1%3B decreased thermal stability%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B loss of argininosuccinate synthase activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27287393;Dbxref=PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_078390;Note=In CTLN1%3B decreased thermal stability%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B loss of argininosuccinate synthase activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27287393;Dbxref=PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_015894;Note=In CTLN1%3B no effect on thermal stability%3B decreased argininosuccinate synthase activity. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=PMID:12815590,PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_015894;Note=In CTLN1%3B no effect on thermal stability%3B decreased argininosuccinate synthase activity. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=PMID:12815590,PMID:27287393
ASS1	P00966	58	121	96	96	Natural variant	ID=VAR_015894;Note=In CTLN1%3B no effect on thermal stability%3B decreased argininosuccinate synthase activity. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=PMID:12815590,PMID:27287393
ASS1	P00966	58	121	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	97	412	Natural variant	ID=VAR_078391;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	100	100	Natural variant	ID=VAR_078392;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs370695114,PMID:28111830
ASS1	P00966	58	121	100	100	Natural variant	ID=VAR_078392;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs370695114,PMID:28111830
ASS1	P00966	58	121	100	100	Natural variant	ID=VAR_078392;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs370695114,PMID:28111830
ASS1	P00966	58	121	100	100	Natural variant	ID=VAR_078393;Note=In CTLN1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs138279074,PMID:28111830
ASS1	P00966	58	121	100	100	Natural variant	ID=VAR_078393;Note=In CTLN1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs138279074,PMID:28111830
ASS1	P00966	58	121	100	100	Natural variant	ID=VAR_078393;Note=In CTLN1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs138279074,PMID:28111830
ASS1	P00966	58	121	108	108	Natural variant	ID=VAR_016014;Note=In CTLN1. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:11941481;Dbxref=dbSNP:rs35269064,PMID:11708871,PMID:11941481
ASS1	P00966	58	121	108	108	Natural variant	ID=VAR_016014;Note=In CTLN1. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:11941481;Dbxref=dbSNP:rs35269064,PMID:11708871,PMID:11941481
ASS1	P00966	58	121	108	108	Natural variant	ID=VAR_016014;Note=In CTLN1. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:11941481;Dbxref=dbSNP:rs35269064,PMID:11708871,PMID:11941481
ASS1	P00966	58	121	111	111	Natural variant	ID=VAR_078394;Note=In CTLN1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	111	111	Natural variant	ID=VAR_078394;Note=In CTLN1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	111	111	Natural variant	ID=VAR_078394;Note=In CTLN1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_078395;Note=In CTLN1. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_078395;Note=In CTLN1. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_078395;Note=In CTLN1. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_015896;Note=In CTLN1. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:12815590;Dbxref=PMID:11708871,PMID:12815590
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_015896;Note=In CTLN1. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:12815590;Dbxref=PMID:11708871,PMID:12815590
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_015896;Note=In CTLN1. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:12815590;Dbxref=PMID:11708871,PMID:12815590
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_015895;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs770944877,PMID:12815590,PMID:27287393
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_015895;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs770944877,PMID:12815590,PMID:27287393
ASS1	P00966	58	121	117	117	Natural variant	ID=VAR_015895;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs770944877,PMID:12815590,PMID:27287393
ASS1	P00966	58	121	118	118	Natural variant	ID=VAR_000684;Note=In CTLN1%3B decreased thermal stability%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:27287393,ECO:0000269|PubMed:7977368;Dbxref=dbSNP:rs775305020,PMID:18473344,PMID:27287393,PMID:7977368
ASS1	P00966	58	121	118	118	Natural variant	ID=VAR_000684;Note=In CTLN1%3B decreased thermal stability%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:27287393,ECO:0000269|PubMed:7977368;Dbxref=dbSNP:rs775305020,PMID:18473344,PMID:27287393,PMID:7977368
ASS1	P00966	58	121	118	118	Natural variant	ID=VAR_000684;Note=In CTLN1%3B decreased thermal stability%3B decreased affinity for aspartate%3B decreased affinity for citrulline%3B decreased argininosuccinate synthase activity. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:27287393,ECO:0000269|PubMed:7977368;Dbxref=dbSNP:rs775305020,PMID:18473344,PMID:27287393,PMID:7977368
ASS1	P00966	58	121	119	119	Natural variant	ID=VAR_016015;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:27287393;Dbxref=PMID:11708871,PMID:27287393
ASS1	P00966	58	121	119	119	Natural variant	ID=VAR_016015;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:27287393;Dbxref=PMID:11708871,PMID:27287393
ASS1	P00966	58	121	119	119	Natural variant	ID=VAR_016015;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:27287393;Dbxref=PMID:11708871,PMID:27287393
ASS1	P00966	121	140	124	124	Natural variant	ID=VAR_058340;Note=In CTLN1%3B loss of argininosuccinate synthase activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs936192871,PMID:16475226,PMID:27287393
ASS1	P00966	121	140	124	124	Natural variant	ID=VAR_058340;Note=In CTLN1%3B loss of argininosuccinate synthase activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs936192871,PMID:16475226,PMID:27287393
ASS1	P00966	121	140	124	124	Natural variant	ID=VAR_058340;Note=In CTLN1%3B loss of argininosuccinate synthase activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs936192871,PMID:16475226,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_078396;Note=Increased thermal stability%3B loss of argininosuccinate synthase activity. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs201623252,PMID:24889030,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_078396;Note=Increased thermal stability%3B loss of argininosuccinate synthase activity. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs201623252,PMID:24889030,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_078396;Note=Increased thermal stability%3B loss of argininosuccinate synthase activity. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs201623252,PMID:24889030,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_058341;Note=In CTLN1%3B increased thermal stability%3B loss of argininosuccinate synthase activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14680976,ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs201623252,PMID:14680976,PMID:19006241,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_058341;Note=In CTLN1%3B increased thermal stability%3B loss of argininosuccinate synthase activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14680976,ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs201623252,PMID:14680976,PMID:19006241,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_058341;Note=In CTLN1%3B increased thermal stability%3B loss of argininosuccinate synthase activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14680976,ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs201623252,PMID:14680976,PMID:19006241,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_058342;Note=In CTLN1%3B severe clinical course%3B loss of argininosuccinate synthase activity. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs771794639,PMID:19006241,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_058342;Note=In CTLN1%3B severe clinical course%3B loss of argininosuccinate synthase activity. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs771794639,PMID:19006241,PMID:27287393
ASS1	P00966	121	140	127	127	Natural variant	ID=VAR_058342;Note=In CTLN1%3B severe clinical course%3B loss of argininosuccinate synthase activity. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs771794639,PMID:19006241,PMID:27287393
ASS1	P00966	121	140	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	121	140	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	138	412	Natural variant	ID=VAR_078397;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	141	141	Natural variant	ID=VAR_072792;Note=In CTLN1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25179242;Dbxref=dbSNP:rs1184442048,PMID:25179242
ASS1	P00966	140	165	141	141	Natural variant	ID=VAR_072792;Note=In CTLN1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25179242;Dbxref=dbSNP:rs1184442048,PMID:25179242
ASS1	P00966	140	165	141	141	Natural variant	ID=VAR_072792;Note=In CTLN1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25179242;Dbxref=dbSNP:rs1184442048,PMID:25179242
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_015897;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs770585183,PMID:12815590,PMID:24889030,PMID:27287393
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_015897;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs770585183,PMID:12815590,PMID:24889030,PMID:27287393
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_015897;Note=In CTLN1%3B decreased thermal stability%3B loss of argininosuccinate synthase activity. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:24889030,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs770585183,PMID:12815590,PMID:24889030,PMID:27287393
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_000685;Note=In CTLN1%3B loss of argininosuccinate synthase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs121908637,PMID:16475226,PMID:2358466,PMID:27287393
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_000685;Note=In CTLN1%3B loss of argininosuccinate synthase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs121908637,PMID:16475226,PMID:2358466,PMID:27287393
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_000685;Note=In CTLN1%3B loss of argininosuccinate synthase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:27287393;Dbxref=dbSNP:rs121908637,PMID:16475226,PMID:2358466,PMID:27287393
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_078398;Note=In CTLN1. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_078398;Note=In CTLN1. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	157	157	Natural variant	ID=VAR_078398;Note=In CTLN1. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	160	160	Natural variant	ID=VAR_058343;Note=In CTLN1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs969835605,PMID:19006241,PMID:28111830
ASS1	P00966	140	165	160	160	Natural variant	ID=VAR_058343;Note=In CTLN1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs969835605,PMID:19006241,PMID:28111830
ASS1	P00966	140	165	160	160	Natural variant	ID=VAR_058343;Note=In CTLN1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs969835605,PMID:19006241,PMID:28111830
ASS1	P00966	140	165	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	163	412	Natural variant	ID=VAR_078399;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	164	164	Natural variant	ID=VAR_078400;Note=In CTLN1. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	164	164	Natural variant	ID=VAR_078400;Note=In CTLN1. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	140	165	164	164	Natural variant	ID=VAR_078400;Note=In CTLN1. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	275	412	Natural variant	ID=VAR_078409;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	275	412	Natural variant	ID=VAR_078409;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	275	412	Natural variant	ID=VAR_078409;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	275	412	Natural variant	ID=VAR_078409;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	275	412	Natural variant	ID=VAR_078409;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	275	412	Natural variant	ID=VAR_078409;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	279	412	Natural variant	ID=VAR_078410;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	279	412	Natural variant	ID=VAR_078410;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	279	412	Natural variant	ID=VAR_078410;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	279	412	Natural variant	ID=VAR_078410;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	279	412	Natural variant	ID=VAR_078410;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	279	412	Natural variant	ID=VAR_078410;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	279	279	Natural variant	ID=VAR_016008;Note=In CTLN1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16475226;Dbxref=dbSNP:rs371265106,PMID:16475226
ASS1	P00966	279	323	279	279	Natural variant	ID=VAR_016008;Note=In CTLN1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16475226;Dbxref=dbSNP:rs371265106,PMID:16475226
ASS1	P00966	279	323	279	279	Natural variant	ID=VAR_016008;Note=In CTLN1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16475226;Dbxref=dbSNP:rs371265106,PMID:16475226
ASS1	P00966	279	323	280	280	Natural variant	ID=VAR_000689;Note=In CTLN1%3B loss of argininosuccinate synthase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7977368,ECO:0000269|PubMed:8792870;Dbxref=PMID:7977368,PMID:8792870
ASS1	P00966	279	323	280	280	Natural variant	ID=VAR_000689;Note=In CTLN1%3B loss of argininosuccinate synthase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7977368,ECO:0000269|PubMed:8792870;Dbxref=PMID:7977368,PMID:8792870
ASS1	P00966	279	323	280	280	Natural variant	ID=VAR_000689;Note=In CTLN1%3B loss of argininosuccinate synthase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7977368,ECO:0000269|PubMed:8792870;Dbxref=PMID:7977368,PMID:8792870
ASS1	P00966	279	323	283	283	Natural variant	ID=VAR_015902;Note=In CTLN1. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:23611581,ECO:0000269|PubMed:24889030;Dbxref=dbSNP:rs765338121,PMID:12815590,PMID:16475226,PMID:23611581,PMID:24889030
ASS1	P00966	279	323	283	283	Natural variant	ID=VAR_015902;Note=In CTLN1. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:23611581,ECO:0000269|PubMed:24889030;Dbxref=dbSNP:rs765338121,PMID:12815590,PMID:16475226,PMID:23611581,PMID:24889030
ASS1	P00966	279	323	283	283	Natural variant	ID=VAR_015902;Note=In CTLN1. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:23611581,ECO:0000269|PubMed:24889030;Dbxref=dbSNP:rs765338121,PMID:12815590,PMID:16475226,PMID:23611581,PMID:24889030
ASS1	P00966	279	323	284	284	Natural variant	ID=VAR_058351;Note=In CTLN1%3B mild clinical course. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs886039853,PMID:19006241,PMID:28111830
ASS1	P00966	279	323	284	284	Natural variant	ID=VAR_058351;Note=In CTLN1%3B mild clinical course. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs886039853,PMID:19006241,PMID:28111830
ASS1	P00966	279	323	284	284	Natural variant	ID=VAR_058351;Note=In CTLN1%3B mild clinical course. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs886039853,PMID:19006241,PMID:28111830
ASS1	P00966	279	323	290	290	Natural variant	ID=VAR_078411;Note=In CTLN1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	290	290	Natural variant	ID=VAR_078411;Note=In CTLN1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	290	290	Natural variant	ID=VAR_078411;Note=In CTLN1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	291	291	Natural variant	ID=VAR_058352;Note=In CTLN1. Y->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	279	323	291	291	Natural variant	ID=VAR_058352;Note=In CTLN1. Y->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	279	323	291	291	Natural variant	ID=VAR_058352;Note=In CTLN1. Y->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	279	323	296	296	Natural variant	ID=VAR_058353;Note=In CTLN1. D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	279	323	296	296	Natural variant	ID=VAR_058353;Note=In CTLN1. D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	279	323	296	296	Natural variant	ID=VAR_058353;Note=In CTLN1. D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19006241,ECO:0000269|PubMed:28111830;Dbxref=PMID:19006241,PMID:28111830
ASS1	P00966	279	323	299	299	Natural variant	ID=VAR_078412;Note=In CTLN1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs768394647,PMID:28111830
ASS1	P00966	279	323	299	299	Natural variant	ID=VAR_078412;Note=In CTLN1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs768394647,PMID:28111830
ASS1	P00966	279	323	299	299	Natural variant	ID=VAR_078412;Note=In CTLN1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs768394647,PMID:28111830
ASS1	P00966	279	323	302	302	Natural variant	ID=VAR_058354;Note=In CTLN1%3B no effect on affinity for aspartate%3B no effect on affinity for citrulline%3B decreased argininosuccinate synthase activity. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:28111830;Dbxref=PMID:18473344,PMID:28111830
ASS1	P00966	279	323	302	302	Natural variant	ID=VAR_058354;Note=In CTLN1%3B no effect on affinity for aspartate%3B no effect on affinity for citrulline%3B decreased argininosuccinate synthase activity. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:28111830;Dbxref=PMID:18473344,PMID:28111830
ASS1	P00966	279	323	302	302	Natural variant	ID=VAR_058354;Note=In CTLN1%3B no effect on affinity for aspartate%3B no effect on affinity for citrulline%3B decreased argininosuccinate synthase activity. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:28111830;Dbxref=PMID:18473344,PMID:28111830
ASS1	P00966	279	323	304	304	Natural variant	ID=VAR_000690;Note=In CTLN1%3B decreased protein abundance. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:7977368;Dbxref=dbSNP:rs121908642,PMID:12815590,PMID:2358466,PMID:7977368
ASS1	P00966	279	323	304	304	Natural variant	ID=VAR_000690;Note=In CTLN1%3B decreased protein abundance. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:7977368;Dbxref=dbSNP:rs121908642,PMID:12815590,PMID:2358466,PMID:7977368
ASS1	P00966	279	323	304	304	Natural variant	ID=VAR_000690;Note=In CTLN1%3B decreased protein abundance. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:7977368;Dbxref=dbSNP:rs121908642,PMID:12815590,PMID:2358466,PMID:7977368
ASS1	P00966	279	323	306	306	Natural variant	ID=VAR_078413;Note=In CTLN1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	306	306	Natural variant	ID=VAR_078413;Note=In CTLN1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	306	306	Natural variant	ID=VAR_078413;Note=In CTLN1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	307	307	Natural variant	ID=VAR_058355;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs183276875,PMID:28111830
ASS1	P00966	279	323	307	307	Natural variant	ID=VAR_058355;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs183276875,PMID:28111830
ASS1	P00966	279	323	307	307	Natural variant	ID=VAR_058355;Note=In CTLN1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs183276875,PMID:28111830
ASS1	P00966	279	323	310	310	Natural variant	ID=VAR_016009;Note=In CTLN1. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs121908648,PMID:12815590
ASS1	P00966	279	323	310	310	Natural variant	ID=VAR_016009;Note=In CTLN1. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs121908648,PMID:12815590
ASS1	P00966	279	323	310	310	Natural variant	ID=VAR_016009;Note=In CTLN1. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs121908648,PMID:12815590
ASS1	P00966	279	323	310	310	Natural variant	ID=VAR_015903;Note=In CTLN1. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15863597;Dbxref=dbSNP:rs199751308,PMID:15863597
ASS1	P00966	279	323	310	310	Natural variant	ID=VAR_015903;Note=In CTLN1. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15863597;Dbxref=dbSNP:rs199751308,PMID:15863597
ASS1	P00966	279	323	310	310	Natural variant	ID=VAR_015903;Note=In CTLN1. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15863597;Dbxref=dbSNP:rs199751308,PMID:15863597
ASS1	P00966	279	323	311	412	Natural variant	ID=VAR_078414;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	311	412	Natural variant	ID=VAR_078414;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	311	412	Natural variant	ID=VAR_078414;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	311	412	Natural variant	ID=VAR_078414;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	311	412	Natural variant	ID=VAR_078414;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	311	412	Natural variant	ID=VAR_078414;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	279	323	321	321	Natural variant	ID=VAR_078415;Note=In CTLN1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs727503813,PMID:28111830
ASS1	P00966	279	323	321	321	Natural variant	ID=VAR_078415;Note=In CTLN1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs727503813,PMID:28111830
ASS1	P00966	279	323	321	321	Natural variant	ID=VAR_078415;Note=In CTLN1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=dbSNP:rs727503813,PMID:28111830
ASS1	P00966	376	397	344	412	Natural variant	ID=VAR_078418;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	344	412	Natural variant	ID=VAR_078418;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	344	412	Natural variant	ID=VAR_078418;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	357	412	Natural variant	ID=VAR_078420;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	357	412	Natural variant	ID=VAR_078420;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	357	412	Natural variant	ID=VAR_078420;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	380	412	Natural variant	ID=VAR_078421;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	380	412	Natural variant	ID=VAR_078421;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	380	412	Natural variant	ID=VAR_078421;Note=In CTLN1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	389	389	Natural variant	ID=VAR_016012;Note=In CTLN1. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs1474017319,PMID:12815590
ASS1	P00966	376	397	389	389	Natural variant	ID=VAR_016012;Note=In CTLN1. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs1474017319,PMID:12815590
ASS1	P00966	376	397	389	389	Natural variant	ID=VAR_016012;Note=In CTLN1. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815590;Dbxref=dbSNP:rs1474017319,PMID:12815590
ASS1	P00966	376	397	389	389	Natural variant	ID=VAR_078422;Note=In CTLN1. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	389	389	Natural variant	ID=VAR_078422;Note=In CTLN1. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	389	389	Natural variant	ID=VAR_078422;Note=In CTLN1. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28111830;Dbxref=PMID:28111830
ASS1	P00966	376	397	390	390	Natural variant	ID=VAR_000694;Note=In CTLN1%3B loss of argininosuccinate synthase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:11941481,ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:24889030;Dbxref=dbSNP:rs121908641,PMID:11708871,PMID:11941481,PMID:12815590,PMID:16475226,PMID:18473344,PMID:2358466,PMID:24889030
ASS1	P00966	376	397	390	390	Natural variant	ID=VAR_000694;Note=In CTLN1%3B loss of argininosuccinate synthase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:11941481,ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:24889030;Dbxref=dbSNP:rs121908641,PMID:11708871,PMID:11941481,PMID:12815590,PMID:16475226,PMID:18473344,PMID:2358466,PMID:24889030
ASS1	P00966	376	397	390	390	Natural variant	ID=VAR_000694;Note=In CTLN1%3B loss of argininosuccinate synthase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11708871,ECO:0000269|PubMed:11941481,ECO:0000269|PubMed:12815590,ECO:0000269|PubMed:16475226,ECO:0000269|PubMed:18473344,ECO:0000269|PubMed:2358466,ECO:0000269|PubMed:24889030;Dbxref=dbSNP:rs121908641,PMID:11708871,PMID:11941481,PMID:12815590,PMID:16475226,PMID:18473344,PMID:2358466,PMID:24889030
ASS1	P00966	140	165	165	165	Mutagenesis	Note=Significant loss of acetylation but no decrease in enzyme activity%3B when associated with Q-176 or R-176. K->Q%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985504;Dbxref=PMID:28985504
ASS1	P00966	140	165	165	165	Mutagenesis	Note=Significant loss of acetylation but no decrease in enzyme activity%3B when associated with Q-176 or R-176. K->Q%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985504;Dbxref=PMID:28985504
ASS1	P00966	140	165	165	165	Mutagenesis	Note=Significant loss of acetylation but no decrease in enzyme activity%3B when associated with Q-176 or R-176. K->Q%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985504;Dbxref=PMID:28985504
ASS1	P00966	35	58	29	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	29	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	29	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	44	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	44	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	44	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	35	58	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	65	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	65	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	65	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	73	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	73	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	73	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	90	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	90	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	90	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	94	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	94	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	94	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	58	121	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	121	140	124	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	121	140	124	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	121	140	124	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	121	140	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	121	140	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	121	140	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	140	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	148	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	148	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	148	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	158	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	158	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	140	165	158	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	277	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	277	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	277	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	285	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	285	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	285	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	304	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	304	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	279	323	304	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	376	397	385	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	376	397	385	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ASS1	P00966	376	397	385	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NZ2
ATAD3C	Q5T2N8	74	126	1	411	Chain	ID=PRO_0000311979;Note=ATPase family AAA domain-containing protein 3C
ATP8B1	O43520	1005	1087	1	1251	Chain	ID=PRO_0000046364;Note=Phospholipid-transporting ATPase IC
ATP8B1	O43520	977	1005	1	1251	Chain	ID=PRO_0000046364;Note=Phospholipid-transporting ATPase IC
ATP8B1	O43520	543	606	1	1251	Chain	ID=PRO_0000046364;Note=Phospholipid-transporting ATPase IC
ATP8B1	O43520	131	164	1	1251	Chain	ID=PRO_0000046364;Note=Phospholipid-transporting ATPase IC
ATP8B1	O43520	93	131	1	1251	Chain	ID=PRO_0000046364;Note=Phospholipid-transporting ATPase IC
ATP8B1	O43520	93	131	1	108	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	93	131	109	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	131	164	131	136	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	93	131	131	136	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	131	164	137	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	131	164	157	340	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	543	606	412	949	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	977	1005	971	982	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	977	1005	983	1002	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	1005	1087	1003	1032	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	977	1005	1003	1032	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	1005	1087	1033	1054	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	1005	1087	1055	1068	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	1005	1087	1069	1091	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP8B1	O43520	93	131	127	127	Natural variant	ID=VAR_043046;Note=In PFIC1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15239083;Dbxref=PMID:15239083
ATP8B1	O43520	543	606	554	554	Natural variant	ID=VAR_015423;Note=In PFIC1%3B greatly reduced expression due to proteosomal degradation%3B abolishes interaction with TMEM30A. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11093741,ECO:0000269|PubMed:15239083,ECO:0000269|PubMed:19731236;Dbxref=dbSNP:rs121909101,PMID:11093741,PMID:15239083,PMID:19731236
ATP8B1	O43520	543	606	577	577	Natural variant	ID=VAR_029272;Note=I->V;Dbxref=dbSNP:rs3745078
ATP8B1	O43520	543	606	580	580	Natural variant	ID=VAR_043062;Note=S->N;Dbxref=dbSNP:rs33963153
ATP8B1	O43520	543	606	600	600	Natural variant	ID=VAR_043063;Note=In BRIC1%3B compound heterozygote with N-70. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15239083;Dbxref=dbSNP:rs1202682161,PMID:15239083
ATP8B1	O43520	543	606	600	600	Natural variant	ID=VAR_043064;Note=In BRIC1. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15239083;Dbxref=PMID:15239083
ATP8B1	O43520	1005	1087	1012	1012	Natural variant	ID=VAR_071046;Note=In PFIC1. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23197899;Dbxref=PMID:23197899
ATP8B1	O43520	1005	1087	1040	1040	Natural variant	ID=VAR_043073;Note=In PFIC1%3B greatly reduces interaction with TMEM30A. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15239083,ECO:0000269|PubMed:19731236;Dbxref=dbSNP:rs1438249656,PMID:15239083,PMID:19731236
ATP8B1	O43520	1005	1087	1016	1016	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP1B3	P54709	36	79	1	279	Chain	ID=PRO_0000219108;Note=Sodium/potassium-transporting ATPase subunit beta-3
ATP1B3	P54709	79	115	1	279	Chain	ID=PRO_0000219108;Note=Sodium/potassium-transporting ATPase subunit beta-3
ATP1B3	P54709	177	194	1	279	Chain	ID=PRO_0000219108;Note=Sodium/potassium-transporting ATPase subunit beta-3
ATP1B3	P54709	194	223	1	279	Chain	ID=PRO_0000219108;Note=Sodium/potassium-transporting ATPase subunit beta-3
ATP1B3	P54709	36	79	36	56	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B3	P54709	36	79	57	279	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B3	P54709	79	115	57	279	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B3	P54709	177	194	57	279	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B3	P54709	194	223	57	279	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B3	P54709	177	194	186	279	Region	Note=immunoglobulin-like;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP1B3	P54709	194	223	186	279	Region	Note=immunoglobulin-like;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP1B3	P54709	177	194	191	250	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP1B3	P54709	194	223	191	250	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP1B3	P54709	36	79	1	36	Alternative sequence	ID=VSP_056686;Note=In isoform 2. MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSW->MLSEGDILFSSLLSSPSLFWPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP1B3	P54709	194	223	195	279	Alternative sequence	ID=VSP_056687;Note=In isoform 2. NEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA->TNNVKDGMKIYQM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARIH1	Q9Y4X5	318	342	1	557	Chain	ID=PRO_0000055752;Note=E3 ubiquitin-protein ligase ARIH1
ARIH1	Q9Y4X5	405	492	1	557	Chain	ID=PRO_0000055752;Note=E3 ubiquitin-protein ligase ARIH1
ARIH1	Q9Y4X5	405	492	408	557	Region	Note=Ariadne domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23707686;Dbxref=PMID:23707686
ARIH1	Q9Y4X5	318	342	340	341	Mutagenesis	Note=Strongly decreased ability to initiate ubiquitination of cullin-RING complexes. NT->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27565346;Dbxref=PMID:27565346
ARIH1	Q9Y4X5	318	342	342	343	Mutagenesis	Note=Strongly decreased ability to initiate ubiquitination of cullin-RING complexes. KE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27565346;Dbxref=PMID:27565346
ARIH1	Q9Y4X5	405	492	416	416	Mutagenesis	Note=Slightly relieves autoinhibition of the E3 ligase activity by the ariadne domain. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23707686;Dbxref=PMID:23707686
ARIH1	Q9Y4X5	405	492	417	417	Mutagenesis	Note=Hyperactive 'open' mutant that displays enhanced E3 ubiquitin-protein ligase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27565346;Dbxref=PMID:27565346
ARIH1	Q9Y4X5	405	492	420	423	Mutagenesis	Note=Slightly relieves autoinhibition of the E3 ligase activity by the ariadne domain. Hyperactive 'open' mutant that displays enhanced E3 ubiquitin-protein ligase activity%3B when associated with A-503. RYMN->AYMA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23707686,ECO:0000269|PubMed:27565346;Dbxref=PMID:23707686,PMID:27565346
ARIH1	Q9Y4X5	405	492	427	427	Mutagenesis	Note=Slightly relieves autoinhibition of the E3 ligase activity by the ariadne domain. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23707686;Dbxref=PMID:23707686
ARIH1	Q9Y4X5	405	492	430	431	Mutagenesis	Note=Relieves autoinhibition of the E3 ligase activity by the ariadne domain%3B when associated with A-503. Hyperactive 'open' mutant that displays enhanced E3 ubiquitin-protein ligase activity%3B when associated with A-503. FE->AA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23707686,ECO:0000269|PubMed:24076655,ECO:0000269|PubMed:27565346;Dbxref=PMID:23707686,PMID:24076655,PMID:27565346
ARIH1	Q9Y4X5	405	492	476	476	Mutagenesis	Note=Hyperactive 'open' mutant that displays enhanced E3 ubiquitin-protein ligase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27565346;Dbxref=PMID:27565346
ARIH1	Q9Y4X5	405	492	492	492	Mutagenesis	Note=Hyperactive 'open' mutant that displays enhanced E3 ubiquitin-protein ligase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27565346;Dbxref=PMID:27565346
ARIH1	Q9Y4X5	318	342	322	322	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARIH1	Q9Y4X5	318	342	317	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARIH1	Q9Y4X5	318	342	326	328	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARIH1	Q9Y4X5	318	342	331	333	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M9Y
ARIH1	Q9Y4X5	318	342	337	340	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M9Y
ARIH1	Q9Y4X5	318	342	341	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARIH1	Q9Y4X5	405	492	411	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARIH1	Q9Y4X5	405	492	434	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARIH1	Q9Y4X5	405	492	452	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARIH1	Q9Y4X5	405	492	486	510	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UDH
ARHGEF15	O94989	200	311	1	841	Chain	ID=PRO_0000080932;Note=Rho guanine nucleotide exchange factor 15
ARHGEF15	O94989	568	593	1	841	Chain	ID=PRO_0000080932;Note=Rho guanine nucleotide exchange factor 15
ARHGEF15	O94989	678	728	1	841	Chain	ID=PRO_0000080932;Note=Rho guanine nucleotide exchange factor 15
ARHGEF15	O94989	200	311	1	841	Chain	ID=PRO_0000080932;Note=Rho guanine nucleotide exchange factor 15
ARHGEF15	O94989	568	593	1	841	Chain	ID=PRO_0000080932;Note=Rho guanine nucleotide exchange factor 15
ARHGEF15	O94989	678	728	1	841	Chain	ID=PRO_0000080932;Note=Rho guanine nucleotide exchange factor 15
ARHGEF15	O94989	568	593	417	601	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF15	O94989	568	593	417	601	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF15	O94989	200	311	277	277	Natural variant	ID=VAR_054216;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.5;Dbxref=dbSNP:rs871841,PMID:14702039,PMID:15489334
ARHGEF15	O94989	200	311	277	277	Natural variant	ID=VAR_054216;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.5;Dbxref=dbSNP:rs871841,PMID:14702039,PMID:15489334
AKR7A2	O43488	162	197	1	359	Chain	ID=PRO_0000070375;Note=Aflatoxin B1 aldehyde reductase member 2
AKR7A2	O43488	162	197	171	172	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.14
AKR7A2	O43488	162	197	197	197	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.14
AKR7A2	O43488	162	197	180	180	Natural variant	ID=VAR_060222;Note=E->K;Dbxref=dbSNP:rs859210
AKR7A2	O43488	162	197	164	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP1
AKR7A2	O43488	162	197	175	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP1
AKR7A2	O43488	162	197	193	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BP1
ARHGEF9	O43307	433	456	1	516	Chain	ID=PRO_0000253895;Note=Rho guanine nucleotide exchange factor 9
ARHGEF9	O43307	308	352	1	516	Chain	ID=PRO_0000253895;Note=Rho guanine nucleotide exchange factor 9
ARHGEF9	O43307	127	187	1	516	Chain	ID=PRO_0000253895;Note=Rho guanine nucleotide exchange factor 9
ARHGEF9	O43307	63	127	1	516	Chain	ID=PRO_0000253895;Note=Rho guanine nucleotide exchange factor 9
ARHGEF9	O43307	63	127	8	67	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ARHGEF9	O43307	127	187	103	287	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF9	O43307	63	127	103	287	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF9	O43307	308	352	318	425	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF9	O43307	63	127	100	110	Region	Note=Interaction with GPHN;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARHGEF9	O43307	63	127	1	102	Alternative sequence	ID=VSP_044555;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGEF9	O43307	63	127	11	63	Alternative sequence	ID=VSP_042921;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGEF9	O43307	63	127	109	109	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGEF9	O43307	63	127	62	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YSQ
ARHGEF12	Q9NZN5	47	66	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	221	261	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	261	308	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	308	333	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	401	434	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	530	540	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	614	685	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	730	741	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	871	913	2	1544	Chain	ID=PRO_0000080930;Note=Rho guanine nucleotide exchange factor 12
ARHGEF12	Q9NZN5	401	434	367	558	Domain	Note=RGSL
ARHGEF12	Q9NZN5	530	540	367	558	Domain	Note=RGSL
ARHGEF12	Q9NZN5	871	913	787	977	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF12	Q9NZN5	221	261	194	262	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARHGEF12	Q9NZN5	261	308	194	262	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARHGEF12	Q9NZN5	261	308	308	309	Site	Note=Breakpoint for translocation to form KMT2A/MLL1-ARHGEF12 oncogene
ARHGEF12	Q9NZN5	308	333	308	309	Site	Note=Breakpoint for translocation to form KMT2A/MLL1-ARHGEF12 oncogene
ARHGEF12	Q9NZN5	308	333	309	309	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ARHGEF12	Q9NZN5	614	685	637	637	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
ARHGEF12	Q9NZN5	730	741	736	736	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:23186163
ARHGEF12	Q9NZN5	47	66	48	66	Alternative sequence	ID=VSP_008131;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10681437,ECO:0000303|PubMed:15489334;Dbxref=PMID:10681437,PMID:15489334
ARHGEF12	Q9NZN5	871	913	865	872	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TXD
ARHGEF12	Q9NZN5	871	913	875	889	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TXD
ARHGEF12	Q9NZN5	871	913	891	904	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TXD
ARHGEF12	Q9NZN5	871	913	906	917	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TXD
ARPC5L	Q9BPX5	74	133	1	153	Chain	ID=PRO_0000279480;Note=Actin-related protein 2/3 complex subunit 5-like protein
ARPC5L	Q9BPX5	74	133	1	153	Chain	ID=PRO_0000279480;Note=Actin-related protein 2/3 complex subunit 5-like protein
ARPP19	P56211	15	56	2	112	Chain	ID=PRO_0000008041;Note=cAMP-regulated phosphoprotein 19
ARPP19	P56211	15	56	2	112	Chain	ID=PRO_0000008041;Note=cAMP-regulated phosphoprotein 19
ARPP19	P56211	15	56	2	112	Chain	ID=PRO_0000008041;Note=cAMP-regulated phosphoprotein 19
ARPP19	P56211	15	56	2	112	Chain	ID=PRO_0000008041;Note=cAMP-regulated phosphoprotein 19
ARPP19	P56211	15	56	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARPP19	P56211	15	56	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARPP19	P56211	15	56	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARPP19	P56211	15	56	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARPP19	P56211	15	56	1	16	Alternative sequence	ID=VSP_018555;Note=In isoform ARPP-16. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8120638;Dbxref=PMID:8120638
ARPP19	P56211	15	56	1	16	Alternative sequence	ID=VSP_018555;Note=In isoform ARPP-16. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8120638;Dbxref=PMID:8120638
ARPP19	P56211	15	56	1	16	Alternative sequence	ID=VSP_018555;Note=In isoform ARPP-16. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8120638;Dbxref=PMID:8120638
ARPP19	P56211	15	56	1	16	Alternative sequence	ID=VSP_018555;Note=In isoform ARPP-16. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8120638;Dbxref=PMID:8120638
ARPC3	O15145	61	84	2	178	Chain	ID=PRO_0000124042;Note=Actin-related protein 2/3 complex subunit 3
ARPC3	O15145	61	84	61	61	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ASB10	Q8WXI3	368	406	1	467	Chain	ID=PRO_0000066942;Note=Ankyrin repeat and SOCS box protein 10
ASB10	Q8WXI3	368	406	369	406	Alternative sequence	ID=VSP_023357;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ASB10	Q8WXI3	368	406	372	372	Natural variant	ID=VAR_069889;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22156576;Dbxref=dbSNP:rs62489646,PMID:22156576
ASB10	Q8WXI3	368	406	402	402	Natural variant	ID=VAR_069890;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22156576;Dbxref=dbSNP:rs919533,PMID:22156576
PPP1R13B	Q96KQ4	118	152	1	1090	Chain	ID=PRO_0000066962;Note=Apoptosis-stimulating of p53 protein 1
PPP1R13B	Q96KQ4	52	92	1	1090	Chain	ID=PRO_0000066962;Note=Apoptosis-stimulating of p53 protein 1
PPP1R13B	Q96KQ4	118	152	132	292	Compositional bias	Note=Gln-rich
PPP1R13B	Q96KQ4	52	92	68	68	Sequence conflict	Note=K->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
LDLRAP1	Q5SW96	177	205	1	308	Chain	ID=PRO_0000064675;Note=Low density lipoprotein receptor adapter protein 1
LDLRAP1	Q5SW96	177	205	42	196	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
LDLRAP1	Q5SW96	177	205	186	186	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LDLRAP1	Q5SW96	177	205	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C142
LDLRAP1	Q5SW96	177	205	202	202	Natural variant	ID=VAR_023320;Note=In ARH%3B Lebanon%3B requires 2 nucleotide substitutions. S->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11326085;Dbxref=dbSNP:rs386629678,PMID:11326085
LDLRAP1	Q5SW96	177	205	202	202	Natural variant	ID=VAR_028403;Note=S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11326085,ECO:0000269|PubMed:12417523,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:20124734;Dbxref=dbSNP:rs6687605,PMID:11326085,PMID:12417523,PMID:15489334,PMID:17974005,PMID:20124734
AKR7L	Q8NHP1	22	56	1	331	Chain	ID=PRO_0000070379;Note=Aflatoxin B1 aldehyde reductase member 4
AKR7L	Q8NHP1	22	56	49	49	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR7L	Q8NHP1	22	56	44	44	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARMC6	Q6NXE6	385	431	1	501	Chain	ID=PRO_0000242660;Note=Armadillo repeat-containing protein 6
ARMC6	Q6NXE6	385	431	1	501	Chain	ID=PRO_0000242660;Note=Armadillo repeat-containing protein 6
ARMC6	Q6NXE6	385	431	370	412	Repeat	Note=ARM 4
ARMC6	Q6NXE6	385	431	370	412	Repeat	Note=ARM 4
ASB5	Q8WWX0	178	223	1	329	Chain	ID=PRO_0000066930;Note=Ankyrin repeat and SOCS box protein 5
ASB5	Q8WWX0	92	128	1	329	Chain	ID=PRO_0000066930;Note=Ankyrin repeat and SOCS box protein 5
ASB5	Q8WWX0	92	128	69	98	Repeat	Note=ANK 1
ASB5	Q8WWX0	92	128	102	131	Repeat	Note=ANK 2
ASB5	Q8WWX0	178	223	167	196	Repeat	Note=ANK 4
ASB5	Q8WWX0	178	223	200	229	Repeat	Note=ANK 5
ASH1L	Q9NR48	2606	2635	1	2969	Chain	ID=PRO_0000259516;Note=Histone-lysine N-methyltransferase ASH1L
ASH1L	Q9NR48	2270	2325	1	2969	Chain	ID=PRO_0000259516;Note=Histone-lysine N-methyltransferase ASH1L
ASH1L	Q9NR48	2116	2184	1	2969	Chain	ID=PRO_0000259516;Note=Histone-lysine N-methyltransferase ASH1L
ASH1L	Q9NR48	1943	2002	1	2969	Chain	ID=PRO_0000259516;Note=Histone-lysine N-methyltransferase ASH1L
ASH1L	Q9NR48	1661	1695	1	2969	Chain	ID=PRO_0000259516;Note=Histone-lysine N-methyltransferase ASH1L
ASH1L	Q9NR48	2116	2184	2091	2142	Domain	Note=AWS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00562
ASH1L	Q9NR48	2116	2184	2145	2261	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
ASH1L	Q9NR48	2270	2325	2269	2285	Domain	Note=Post-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00155
ASH1L	Q9NR48	2606	2635	2585	2631	Zinc finger	Note=PHD-type
ASH1L	Q9NR48	2270	2325	2069	2288	Region	Note=Catalytic domain
ASH1L	Q9NR48	2116	2184	2069	2288	Region	Note=Catalytic domain
ASH1L	Q9NR48	1661	1695	1580	1791	Compositional bias	Note=Ser-rich
ASH1L	Q9NR48	2270	2325	2317	2317	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8
ASH1L	Q9NR48	2270	2325	2319	2319	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8
ASH1L	Q9NR48	2270	2325	2323	2323	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8
ASH1L	Q9NR48	2606	2635	2148	2969	Natural variant	ID=VAR_080560;Note=In MRD52. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
ASH1L	Q9NR48	2270	2325	2148	2969	Natural variant	ID=VAR_080560;Note=In MRD52. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
ASH1L	Q9NR48	2116	2184	2148	2969	Natural variant	ID=VAR_080560;Note=In MRD52. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889
ASH1L	Q9NR48	2116	2184	2114	2117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2124	2126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2130	2132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2133	2135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YPU
ASH1L	Q9NR48	2116	2184	2137	2141	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2147	2151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2155	2163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2170	2173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2177	2180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2116	2184	2181	2190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
ASH1L	Q9NR48	2270	2325	2282	2284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNM
HSD3B2	P26439	47	102	1	372	Chain	ID=PRO_0000087775;Note=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
HSD3B2	P26439	47	102	1	372	Chain	ID=PRO_0000087775;Note=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
HSD3B2	P26439	47	102	74	74	Natural variant	ID=VAR_048099;Note=D->N;Dbxref=dbSNP:rs4986954
HSD3B2	P26439	47	102	74	74	Natural variant	ID=VAR_048099;Note=D->N;Dbxref=dbSNP:rs4986954
HSD3B2	P26439	47	102	82	82	Natural variant	ID=VAR_070028;Note=In AH2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22579964;Dbxref=PMID:22579964
HSD3B2	P26439	47	102	82	82	Natural variant	ID=VAR_070028;Note=In AH2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22579964;Dbxref=PMID:22579964
HSD3B2	P26439	47	102	82	82	Natural variant	ID=VAR_010520;Note=In AH2. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10599696,ECO:0000269|PubMed:8185809;Dbxref=dbSNP:rs757033996,PMID:10599696,PMID:8185809
HSD3B2	P26439	47	102	82	82	Natural variant	ID=VAR_010520;Note=In AH2. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10599696,ECO:0000269|PubMed:8185809;Dbxref=dbSNP:rs757033996,PMID:10599696,PMID:8185809
HSD3B2	P26439	47	102	94	94	Natural variant	ID=VAR_014818;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs6211,PMID:17974005
HSD3B2	P26439	47	102	94	94	Natural variant	ID=VAR_014818;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs6211,PMID:17974005
HSD3B2	P26439	47	102	100	100	Natural variant	ID=VAR_010521;Note=In AH2%3B nonsalt-wasting form. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10599696,ECO:0000269|PubMed:7608265;Dbxref=dbSNP:rs1388517943,PMID:10599696,PMID:7608265
HSD3B2	P26439	47	102	100	100	Natural variant	ID=VAR_010521;Note=In AH2%3B nonsalt-wasting form. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10599696,ECO:0000269|PubMed:7608265;Dbxref=dbSNP:rs1388517943,PMID:10599696,PMID:7608265
HSD3B2	P26439	47	102	52	53	Sequence conflict	Note=RT->KI;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD3B2	P26439	47	102	52	53	Sequence conflict	Note=RT->KI;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD3B2	P26439	47	102	92	94	Sequence conflict	Note=HRE->RRQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSD3B2	P26439	47	102	92	94	Sequence conflict	Note=HRE->RRQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB9	Q9NP78	460	523	1	766	Chain	ID=PRO_0000000252;Note=ATP-binding cassette sub-family B member 9
ABCB9	Q9NP78	417	460	1	766	Chain	ID=PRO_0000000252;Note=ATP-binding cassette sub-family B member 9
ABCB9	Q9NP78	460	523	1	766	Chain	ID=PRO_0000000252;Note=ATP-binding cassette sub-family B member 9
ABCB9	Q9NP78	417	460	1	766	Chain	ID=PRO_0000000252;Note=ATP-binding cassette sub-family B member 9
ABCB9	Q9NP78	460	523	1	766	Chain	ID=PRO_0000000252;Note=ATP-binding cassette sub-family B member 9
ABCB9	Q9NP78	417	460	1	766	Chain	ID=PRO_0000000252;Note=ATP-binding cassette sub-family B member 9
ABCB9	Q9NP78	417	460	416	436	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	417	460	416	436	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	417	460	416	436	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	460	523	188	471	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	417	460	188	471	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	460	523	188	471	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	417	460	188	471	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	460	523	188	471	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	417	460	188	471	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB9	Q9NP78	460	523	504	740	Domain	Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB9	Q9NP78	460	523	504	740	Domain	Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB9	Q9NP78	460	523	504	740	Domain	Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCB9	Q9NP78	460	523	418	460	Alternative sequence	ID=VSP_000027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10748049;Dbxref=PMID:10748049
ABCB9	Q9NP78	417	460	418	460	Alternative sequence	ID=VSP_000027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10748049;Dbxref=PMID:10748049
ABCB9	Q9NP78	460	523	418	460	Alternative sequence	ID=VSP_000027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10748049;Dbxref=PMID:10748049
ABCB9	Q9NP78	417	460	418	460	Alternative sequence	ID=VSP_000027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10748049;Dbxref=PMID:10748049
ABCB9	Q9NP78	460	523	418	460	Alternative sequence	ID=VSP_000027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10748049;Dbxref=PMID:10748049
ABCB9	Q9NP78	417	460	418	460	Alternative sequence	ID=VSP_000027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10748049;Dbxref=PMID:10748049
ABCB9	Q9NP78	460	523	461	523	Alternative sequence	ID=VSP_044884;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB9	Q9NP78	460	523	461	523	Alternative sequence	ID=VSP_044884;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB9	Q9NP78	460	523	461	523	Alternative sequence	ID=VSP_044884;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACOT8	O14734	215	280	1	319	Chain	ID=PRO_0000202152;Note=Acyl-coenzyme A thioesterase 8
ACOT8	O14734	215	280	232	232	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACOT8	O14734	215	280	254	254	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACTN1	P12814	760	787	1	892	Chain	ID=PRO_0000073431;Note=Alpha-actinin-1
ACTN1	P12814	545	606	1	892	Chain	ID=PRO_0000073431;Note=Alpha-actinin-1
ACTN1	P12814	498	545	1	892	Chain	ID=PRO_0000073431;Note=Alpha-actinin-1
ACTN1	P12814	254	285	1	892	Chain	ID=PRO_0000073431;Note=Alpha-actinin-1
ACTN1	P12814	113	142	1	892	Chain	ID=PRO_0000073431;Note=Alpha-actinin-1
ACTN1	P12814	73	113	1	892	Chain	ID=PRO_0000073431;Note=Alpha-actinin-1
ACTN1	P12814	113	142	31	135	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
ACTN1	P12814	73	113	31	135	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
ACTN1	P12814	254	285	274	384	Repeat	Note=Spectrin 1
ACTN1	P12814	498	545	394	499	Repeat	Note=Spectrin 2
ACTN1	P12814	545	606	509	620	Repeat	Note=Spectrin 3
ACTN1	P12814	498	545	509	620	Repeat	Note=Spectrin 3
ACTN1	P12814	760	787	746	781	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
ACTN1	P12814	760	787	787	822	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
ACTN1	P12814	760	787	759	770	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
ACTN1	P12814	113	142	1	247	Region	Note=Actin-binding
ACTN1	P12814	73	113	1	247	Region	Note=Actin-binding
ACTN1	P12814	545	606	274	733	Region	Note=Interaction with DDN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16464232;Dbxref=PMID:16464232
ACTN1	P12814	498	545	274	733	Region	Note=Interaction with DDN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16464232;Dbxref=PMID:16464232
ACTN1	P12814	254	285	274	733	Region	Note=Interaction with DDN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16464232;Dbxref=PMID:16464232
ACTN1	P12814	73	113	95	95	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACTN1	P12814	760	787	761	787	Alternative sequence	ID=VSP_041264;Note=In isoform 2 and isoform 4. DHSGTLGPEEFKACLISLGYDIGNDPQ->KKTGMMDTDDFRACLISMGYNM;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:18353764,ECO:0000303|Ref.5;Dbxref=PMID:14702039,PMID:18353764
ACTN1	P12814	760	787	787	787	Alternative sequence	ID=VSP_043525;Note=In isoform 3. Q->QKKTGMMDTDDFRACLISMGYNM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
ACTN1	P12814	73	113	105	105	Natural variant	ID=VAR_069912;Note=In BDPLT15%3B the mutation dominantly affects the actin filament assembly likely resulting in abnormal cytoskeletal organization. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23434115;Dbxref=dbSNP:rs387907345,PMID:23434115
ACTN1	P12814	760	787	778	778	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACTN1	P12814	73	113	63	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EYI
ACTN1	P12814	73	113	86	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EYI
ACTN1	P12814	113	142	112	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EYI
ACTN1	P12814	73	113	112	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EYI
ACTN1	P12814	113	142	120	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EYI
ACTN1	P12814	113	142	136	138	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EYI
ACTN1	P12814	760	787	763	766	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N8Y
ACTN1	P12814	760	787	768	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N8Y
ACTN1	P12814	760	787	775	778	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N8Y
ALDH16A1	Q8IZ83	253	304	1	802	Chain	ID=PRO_0000312986;Note=Aldehyde dehydrogenase family 16 member A1
ALDH16A1	Q8IZ83	253	304	254	308	Alternative sequence	ID=VSP_029982;Note=In isoform 2. EGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLR->VPSGQGSWRNAAGGRKAPPAAELGGVPRKGVPFDGAWRESVRSWAWRWGRSRCCC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ALDH16A1	Q8IZ83	253	304	254	304	Alternative sequence	ID=VSP_043280;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCA3	Q99758	805	837	1	1704	Chain	ID=PRO_0000093293;Note=ATP-binding cassette sub-family A member 3
ABCA3	Q99758	489	537	1	1704	Chain	ID=PRO_0000093293;Note=ATP-binding cassette sub-family A member 3
ABCA3	Q99758	370	428	1	1704	Chain	ID=PRO_0000093293;Note=ATP-binding cassette sub-family A member 3
ABCA3	Q99758	291	330	1	1704	Chain	ID=PRO_0000093293;Note=ATP-binding cassette sub-family A member 3
ABCA3	Q99758	291	330	307	327	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA3	Q99758	370	428	373	393	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA3	Q99758	370	428	405	425	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA3	Q99758	489	537	530	763	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA3	Q99758	805	837	210	1704	Alternative sequence	ID=VSP_056263;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA3	Q99758	489	537	210	1704	Alternative sequence	ID=VSP_056263;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA3	Q99758	370	428	210	1704	Alternative sequence	ID=VSP_056263;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA3	Q99758	291	330	210	1704	Alternative sequence	ID=VSP_056263;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCB7	O75027	111	151	23	752	Chain	ID=PRO_0000000249;Note=ATP-binding cassette sub-family B member 7%2C mitochondrial
ABCB7	O75027	56	82	23	752	Chain	ID=PRO_0000000249;Note=ATP-binding cassette sub-family B member 7%2C mitochondrial
ABCB7	O75027	111	151	141	161	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB7	O75027	111	151	140	436	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB7	O75027	56	82	56	56	Alternative sequence	ID=VSP_014635;Note=In isoform 2. Q->QQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
ABCB7	O75027	111	151	112	151	Alternative sequence	ID=VSP_054700;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB7	O75027	111	151	141	141	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACAD10	Q6JQN1	112	177	1	1059	Chain	ID=PRO_0000284770;Note=Acyl-CoA dehydrogenase family member 10
ACAD10	Q6JQN1	331	353	1	1059	Chain	ID=PRO_0000284770;Note=Acyl-CoA dehydrogenase family member 10
ACAD10	Q6JQN1	513	571	1	1059	Chain	ID=PRO_0000284770;Note=Acyl-CoA dehydrogenase family member 10
ACAD10	Q6JQN1	705	752	1	1059	Chain	ID=PRO_0000284770;Note=Acyl-CoA dehydrogenase family member 10
ACAD10	Q6JQN1	112	177	1	398	Alternative sequence	ID=VSP_024630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACAD10	Q6JQN1	331	353	1	398	Alternative sequence	ID=VSP_024630;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACAD10	Q6JQN1	331	353	286	1059	Alternative sequence	ID=VSP_024632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAD10	Q6JQN1	513	571	286	1059	Alternative sequence	ID=VSP_024632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAD10	Q6JQN1	705	752	286	1059	Alternative sequence	ID=VSP_024632;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAD10	Q6JQN1	112	177	124	124	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACMSD	Q8TDX5	193	225	1	336	Chain	ID=PRO_0000190979;Note=2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
ACMSD	Q8TDX5	193	225	194	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OFC
ACMSD	Q8TDX5	193	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OFC
ACMSD	Q8TDX5	193	225	211	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OFC
ACMSD	Q8TDX5	193	225	220	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OFC
ACMSD	Q8TDX5	193	225	224	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OFC
PPP2R5C	Q13362	135	166	1	524	Chain	ID=PRO_0000071457;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
PPP2R5C	Q13362	210	229	1	524	Chain	ID=PRO_0000071457;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
PPP2R5C	Q13362	284	341	1	524	Chain	ID=PRO_0000071457;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
PPP2R5C	Q13362	384	417	1	524	Chain	ID=PRO_0000071457;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
PPP2R5C	Q13362	442	481	1	524	Chain	ID=PRO_0000071457;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
PPP2R5C	Q13362	384	417	416	422	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PPP2R5C	Q13362	442	481	443	524	Alternative sequence	ID=VSP_005112;Note=In isoform Gamma-1. YTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR->VLKKRIT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7592815,ECO:0000303|PubMed:8694763;Dbxref=PMID:7592815,PMID:8694763
PPP2R5C	Q13362	442	481	443	481	Alternative sequence	ID=VSP_005113;Note=In isoform Gamma-2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7584044;Dbxref=PMID:14702039,PMID:7584044
PPP2R5C	Q13362	135	166	131	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	135	166	152	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	135	166	156	158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	135	166	161	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	210	229	197	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	210	229	221	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	284	341	282	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	284	341	301	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	284	341	317	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	284	341	340	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJA
PPP2R5C	Q13362	384	417	384	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FGA
PPP2R5C	Q13362	384	417	409	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FGA
ABCA7	Q8IZY2	349	405	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	756	793	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	851	894	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1317	1401	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1402	1412	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1904	1949	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1984	2014	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	349	405	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	756	793	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	851	894	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1317	1401	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1402	1412	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1904	1949	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	1984	2014	1	2146	Chain	ID=PRO_0000250674;Note=ATP-binding cassette sub-family A member 7
ABCA7	Q8IZY2	349	405	43	549	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	349	405	43	549	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	851	894	849	869	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA7	Q8IZY2	851	894	849	869	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA7	Q8IZY2	1317	1401	1264	1537	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	1402	1412	1264	1537	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	1317	1401	1264	1537	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	1402	1412	1264	1537	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	851	894	807	1038	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA7	Q8IZY2	851	894	807	1038	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA7	Q8IZY2	1904	1949	1793	2025	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA7	Q8IZY2	1984	2014	1793	2025	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA7	Q8IZY2	1904	1949	1793	2025	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA7	Q8IZY2	1984	2014	1793	2025	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA7	Q8IZY2	1317	1401	1345	1359	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	1317	1401	1345	1359	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCA7	Q8IZY2	349	405	395	395	Natural variant	ID=VAR_027583;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111378;Dbxref=dbSNP:rs3764647,PMID:12111378
ABCA7	Q8IZY2	349	405	395	395	Natural variant	ID=VAR_027583;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111378;Dbxref=dbSNP:rs3764647,PMID:12111378
ABCA7	Q8IZY2	1317	1401	1349	1349	Natural variant	ID=VAR_027586;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10873640,ECO:0000269|PubMed:11355874,ECO:0000269|PubMed:12111378;Dbxref=dbSNP:rs3745842,PMID:10873640,PMID:11355874,PMID:12111378
ABCA7	Q8IZY2	1317	1401	1349	1349	Natural variant	ID=VAR_027586;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10873640,ECO:0000269|PubMed:11355874,ECO:0000269|PubMed:12111378;Dbxref=dbSNP:rs3745842,PMID:10873640,PMID:11355874,PMID:12111378
ABCC9	O60706	733	745	1	1549	Chain	ID=PRO_0000093402;Note=ATP-binding cassette sub-family C member 9
ABCC9	O60706	637	673	1	1549	Chain	ID=PRO_0000093402;Note=ATP-binding cassette sub-family C member 9
ABCC9	O60706	388	440	1	1549	Chain	ID=PRO_0000093402;Note=ATP-binding cassette sub-family C member 9
ABCC9	O60706	191	272	1	1549	Chain	ID=PRO_0000093402;Note=ATP-binding cassette sub-family C member 9
ABCC9	O60706	191	272	189	301	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC9	O60706	388	440	372	423	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC9	O60706	388	440	424	444	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC9	O60706	733	745	593	990	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC9	O60706	637	673	593	990	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC9	O60706	388	440	297	597	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC9	O60706	733	745	672	912	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC9	O60706	637	673	672	912	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC9	O60706	191	272	207	207	Natural variant	ID=VAR_068486;Note=In HTOCD. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22610116;Dbxref=PMID:22610116
ABCC9	O60706	388	440	432	432	Natural variant	ID=VAR_068488;Note=In HTOCD%3B mutant channels show reduced ATP sensitivity%3B rat ABCC9 construct containing this mutation shows gain of function. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22610116,ECO:0000269|PubMed:26621776;Dbxref=PMID:22610116,PMID:26621776
AASS	Q9UDR5	728	760	33	926	Chain	ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial
AASS	Q9UDR5	672	728	33	926	Chain	ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial
AASS	Q9UDR5	728	760	33	926	Chain	ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial
AASS	Q9UDR5	672	728	33	926	Chain	ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial
AASS	Q9UDR5	728	760	477	926	Region	Note=Saccharopine dehydrogenase
AASS	Q9UDR5	672	728	477	926	Region	Note=Saccharopine dehydrogenase
AASS	Q9UDR5	728	760	477	926	Region	Note=Saccharopine dehydrogenase
AASS	Q9UDR5	672	728	477	926	Region	Note=Saccharopine dehydrogenase
AASS	Q9UDR5	672	728	724	726	Region	Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4
AASS	Q9UDR5	672	728	724	726	Region	Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4
AASS	Q9UDR5	672	728	703	703	Binding site	Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4
AASS	Q9UDR5	672	728	703	703	Binding site	Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4
AASS	Q9UDR5	672	728	707	707	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67
AASS	Q9UDR5	672	728	707	707	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67
AASS	Q9UDR5	728	760	732	732	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67
AASS	Q9UDR5	728	760	732	732	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67
AASS	Q9UDR5	728	760	739	739	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67
AASS	Q9UDR5	728	760	739	739	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67
AASS	Q9UDR5	672	728	672	676	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	672	676	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	679	685	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	679	685	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	687	689	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	687	689	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	697	701	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	697	701	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	703	705	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	703	705	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	708	712	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	708	712	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	718	727	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	672	728	718	727	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	728	760	730	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	728	760	730	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	728	760	760	768	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
AASS	Q9UDR5	728	760	760	768	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O1P
ABCD3	P28288	510	540	1	659	Chain	ID=PRO_0000093309;Note=ATP-binding cassette sub-family D member 3
ABCD3	P28288	580	615	1	659	Chain	ID=PRO_0000093309;Note=ATP-binding cassette sub-family D member 3
ABCD3	P28288	615	634	1	659	Chain	ID=PRO_0000093309;Note=ATP-binding cassette sub-family D member 3
ABCD3	P28288	510	540	440	659	Domain	Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCD3	P28288	580	615	440	659	Domain	Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCD3	P28288	615	634	440	659	Domain	Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCD3	P28288	510	540	533	533	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P55096
ABCD3	P28288	510	540	237	659	Alternative sequence	ID=VSP_031188;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ABCD3	P28288	580	615	237	659	Alternative sequence	ID=VSP_031188;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ABCD3	P28288	615	634	237	659	Alternative sequence	ID=VSP_031188;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ABCD3	P28288	615	634	616	634	Sequence conflict	Note=VGITLFTVSHRKSLWKHHE->GWHHSLHLCLIGNLFGNIMR;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABHD6	Q9BV23	92	130	1	337	Chain	ID=PRO_0000281575;Note=Monoacylglycerol lipase ABHD6
ABHD6	Q9BV23	92	130	1	337	Chain	ID=PRO_0000281575;Note=Monoacylglycerol lipase ABHD6
ABHD6	Q9BV23	92	130	30	337	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD6	Q9BV23	92	130	30	337	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD6	Q9BV23	92	130	72	313	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD6	Q9BV23	92	130	72	313	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA2	Q9BZC7	2244	2274	1	2435	Chain	ID=PRO_0000093290;Note=ATP-binding cassette sub-family A member 2
ABCA2	Q9BZC7	1034	1104	1	2435	Chain	ID=PRO_0000093290;Note=ATP-binding cassette sub-family A member 2
ABCA2	Q9BZC7	1034	1104	990	1221	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA2	Q9BZC7	2244	2274	2050	2285	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCA2	Q9BZC7	2244	2274	2091	2435	Alternative sequence	ID=VSP_035284;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10470851;Dbxref=PMID:10470851
ACADSB	P45954	101	170	34	432	Chain	ID=PRO_0000000519;Note=Short/branched chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADSB	P45954	330	376	34	432	Chain	ID=PRO_0000000519;Note=Short/branched chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADSB	P45954	330	376	330	330	Binding site	Note=FAD%3B shared with dimeric partner;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12
ACADSB	P45954	101	170	1	102	Alternative sequence	ID=VSP_055778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACADSB	P45954	330	376	376	376	Natural variant	ID=VAR_048179;Note=E->G;Dbxref=dbSNP:rs12357783
ACADSB	P45954	101	170	100	103	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	101	170	104	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	101	170	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	101	170	118	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	101	170	133	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	101	170	146	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	101	170	156	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	330	376	330	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACADSB	P45954	330	376	364	389	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIF
ACLY	P53396	979	1017	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	718	755	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	590	625	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	476	486	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	53	94	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	979	1017	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	718	755	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	590	625	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	476	486	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	53	94	1	1101	Chain	ID=PRO_0000102781;Note=ATP-citrate synthase
ACLY	P53396	53	94	4	265	Domain	Note=ATP-grasp
ACLY	P53396	53	94	4	265	Domain	Note=ATP-grasp
ACLY	P53396	53	94	66	67	Nucleotide binding	Note=ATP
ACLY	P53396	53	94	66	67	Nucleotide binding	Note=ATP
ACLY	P53396	718	755	701	721	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACLY	P53396	718	755	701	721	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACLY	P53396	718	755	752	778	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACLY	P53396	718	755	752	778	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACLY	P53396	718	755	718	718	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACLY	P53396	718	755	718	718	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACLY	P53396	53	94	58	58	Binding site	Note=ATP
ACLY	P53396	53	94	58	58	Binding site	Note=ATP
ACLY	P53396	476	486	481	481	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:17924679,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
ACLY	P53396	476	486	481	481	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:17924679,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
ACLY	P53396	476	486	476	485	Alternative sequence	ID=VSP_042201;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACLY	P53396	476	486	476	485	Alternative sequence	ID=VSP_042201;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACLY	P53396	53	94	75	75	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACLY	P53396	53	94	75	75	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACLY	P53396	718	755	728	728	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACLY	P53396	718	755	728	728	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACLY	P53396	53	94	55	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	55	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	66	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	66	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	78	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	78	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	86	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	86	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	92	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	53	94	92	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	593	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	593	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	603	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	603	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	619	621	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	619	621	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	590	625	623	625	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TE1
ACLY	P53396	590	625	623	625	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TE1
ACLY	P53396	718	755	712	722	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	712	722	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	725	732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	725	732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	740	745	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	740	745	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	747	751	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	747	751	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDE
ACLY	P53396	718	755	752	754	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDZ
ACLY	P53396	718	755	752	754	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDZ
PPP2R5D	Q14738	211	242	1	602	Chain	ID=PRO_0000071452;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
PPP2R5D	Q14738	342	360	1	602	Chain	ID=PRO_0000071452;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
PPP2R5D	Q14738	518	557	1	602	Chain	ID=PRO_0000071452;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
PPP2R5D	Q14738	518	557	523	530	Motif	Note=SH3-binding%3B class I;Ontology_term=ECO:0000255;evidence=ECO:0000255
PPP2R5D	Q14738	518	557	548	565	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SH3BP5L	Q7L8J4	179	237	1	393	Chain	ID=PRO_0000317508;Note=SH3 domain-binding protein 5-like
SH3BP5L	Q7L8J4	179	237	169	272	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ORM1	P02763	109	145	19	201	Chain	ID=PRO_0000017860;Note=Alpha-1-acid glycoprotein 1
ORM1	P02763	109	145	23	165	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:4603214;Dbxref=PMID:4603214
ORM1	P02763	109	145	90	183	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:4603214;Dbxref=PMID:4603214
ORM1	P02763	109	145	105	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KQ0
ORM1	P02763	109	145	113	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KQ0
ORM1	P02763	109	145	127	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KQ0
ORM1	P02763	109	145	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KQ0
ORM1	P02763	109	145	141	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KQ0
ABCA4	P78363	1418	1450	1	2273	Chain	ID=PRO_0000093301;Note=Retinal-specific ATP-binding cassette transporter
ABCA4	P78363	720	794	1	2273	Chain	ID=PRO_0000093301;Note=Retinal-specific ATP-binding cassette transporter
ABCA4	P78363	720	794	700	720	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA4	P78363	720	794	731	751	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA4	P78363	720	794	760	780	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA4	P78363	1418	1450	1398	1727	Topological domain	Note=Extracellular
ABCA4	P78363	720	794	752	752	Natural variant	ID=VAR_014703;Note=S->I;Dbxref=dbSNP:rs1801369
ABCA4	P78363	720	794	762	762	Natural variant	ID=VAR_067427;Note=In ARMD2. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19028736;Dbxref=PMID:19028736
ABCA4	P78363	720	794	764	764	Natural variant	ID=VAR_012532;Note=In STGD1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958763;Dbxref=dbSNP:rs61749428,PMID:10958763
ABCA4	P78363	720	794	765	765	Natural variant	ID=VAR_012534;Note=In STGD1. S->N;Dbxref=dbSNP:rs61749429
ABCA4	P78363	720	794	765	765	Natural variant	ID=VAR_012533;Note=In STGD1. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958763;Dbxref=dbSNP:rs61752404,PMID:10958763
ABCA4	P78363	720	794	767	767	Natural variant	ID=VAR_012535;Note=In STGD1. V->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10711710,ECO:0000269|PubMed:11527935,ECO:0000269|PubMed:18977788;Dbxref=dbSNP:rs61751395,PMID:10711710,PMID:11527935,PMID:18977788
ABCA4	P78363	1418	1450	1428	1428	Natural variant	ID=VAR_008447;Note=In ARMD2. T->M;Dbxref=dbSNP:rs1800549
ABCA4	P78363	1418	1450	1429	1429	Natural variant	ID=VAR_008448;Note=In STGD1. V->A;Dbxref=dbSNP:rs61752432
ABCA4	P78363	1418	1450	1430	1430	Natural variant	ID=VAR_012572;Note=In STGD1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958763;Dbxref=PMID:10958763
ABCA4	P78363	1418	1450	1433	1433	Natural variant	ID=VAR_008449;Note=In STGD1. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18977788;Dbxref=dbSNP:rs56357060,PMID:18977788
ABCA4	P78363	1418	1450	1439	1439	Natural variant	ID=VAR_008450;Note=In STGD1. G->D;Dbxref=dbSNP:rs61750140
ABCA4	P78363	1418	1450	1440	1440	Natural variant	ID=VAR_008451;Note=In STGD1. F->S;Dbxref=dbSNP:rs61750141
ABCA4	P78363	1418	1450	1440	1440	Natural variant	ID=VAR_012573;Note=In STGD1. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958763;Dbxref=dbSNP:rs61752433,PMID:10958763
ABCA4	P78363	1418	1450	1443	1443	Natural variant	ID=VAR_012574;Note=In STGD1. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10958763;Dbxref=dbSNP:rs61750142,PMID:10958763
ABCA4	P78363	720	794	722	722	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCC8	Q09428	1515	1536	1	1581	Chain	ID=PRO_0000093400;Note=ATP-binding cassette sub-family C member 8
ABCC8	Q09428	1251	1289	1	1581	Chain	ID=PRO_0000093400;Note=ATP-binding cassette sub-family C member 8
ABCC8	Q09428	852	898	1	1581	Chain	ID=PRO_0000093400;Note=ATP-binding cassette sub-family C member 8
ABCC8	Q09428	741	751	1	1581	Chain	ID=PRO_0000093400;Note=ATP-binding cassette sub-family C member 8
ABCC8	Q09428	392	444	1	1581	Chain	ID=PRO_0000093400;Note=ATP-binding cassette sub-family C member 8
ABCC8	Q09428	392	444	377	434	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC8	Q09428	392	444	435	455	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC8	Q09428	852	898	606	1004	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC8	Q09428	741	751	606	1004	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC8	Q09428	1251	1289	1181	1251	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC8	Q09428	1251	1289	1252	1272	Transmembrane	Note=Helical%3B Name%3D16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC8	Q09428	1251	1289	1273	1276	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC8	Q09428	1251	1289	1277	1297	Transmembrane	Note=Helical%3B Name%3D17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC8	Q09428	1515	1536	1298	1581	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ABCC8	Q09428	392	444	299	602	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC8	Q09428	852	898	679	929	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC8	Q09428	741	751	679	929	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC8	Q09428	1251	1289	1012	1306	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC8	Q09428	1515	1536	1344	1578	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC8	Q09428	1515	1536	51	1581	Alternative sequence	ID=VSP_044090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21671119;Dbxref=PMID:21671119
ABCC8	Q09428	1251	1289	51	1581	Alternative sequence	ID=VSP_044090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21671119;Dbxref=PMID:21671119
ABCC8	Q09428	852	898	51	1581	Alternative sequence	ID=VSP_044090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21671119;Dbxref=PMID:21671119
ABCC8	Q09428	741	751	51	1581	Alternative sequence	ID=VSP_044090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21671119;Dbxref=PMID:21671119
ABCC8	Q09428	392	444	51	1581	Alternative sequence	ID=VSP_044090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21671119;Dbxref=PMID:21671119
ABCC8	Q09428	392	444	406	406	Natural variant	ID=VAR_008644;Note=In HHF1. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9618169;Dbxref=dbSNP:rs72559728,PMID:9618169
ABCC8	Q09428	392	444	418	418	Natural variant	ID=VAR_031359;Note=In HHF1. C->R;Dbxref=dbSNP:rs67254669
ABCC8	Q09428	392	444	435	435	Natural variant	ID=VAR_029780;Note=In TNDM2. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16885549;Dbxref=PMID:16885549
ABCC8	Q09428	852	898	889	889	Natural variant	ID=VAR_031369;Note=In HHF1%3B no effect on cell membrane expression%3B no effect on traffic efficiency%3B reduced potassium channel response to activators such as MgADP or to diazoxide. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24814349;Dbxref=dbSNP:rs761862121,PMID:24814349
ABCC8	Q09428	852	898	890	890	Natural variant	ID=VAR_072943;Note=In HHF1%3B no effect on cell membrane expression%3B no effect on traffic efficiency%3B dramatically reduced potassium channel response to activators such as MgADP or to diazoxide. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24814349;Dbxref=PMID:24814349
ABCC8	Q09428	1515	1536	1522	1522	Natural variant	ID=VAR_072953;Note=In PNDM%3B highly reduced inhibition by ATP when associated whith I-229. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17668386;Dbxref=PMID:17668386
ABCC11	Q96J66	1259	1297	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	1086	1116	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	836	902	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	536	560	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	416	452	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	1259	1297	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	1086	1116	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	836	902	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	536	560	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	416	452	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	1259	1297	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	1086	1116	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	836	902	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	536	560	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	416	452	1	1382	Chain	ID=PRO_0000225594;Note=ATP-binding cassette sub-family C member 11
ABCC11	Q96J66	416	452	418	438	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	416	452	418	438	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	416	452	418	438	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	536	560	439	806	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	416	452	439	806	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	536	560	439	806	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	416	452	439	806	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	536	560	439	806	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	416	452	439	806	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	836	902	864	884	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	836	902	864	884	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	836	902	864	884	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	1259	1297	1071	1382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	1086	1116	1071	1382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	1259	1297	1071	1382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	1086	1116	1071	1382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	1259	1297	1071	1382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	1086	1116	1071	1382	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCC11	Q96J66	416	452	163	443	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	416	452	163	443	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	416	452	163	443	Domain	Note=ABC transmembrane type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	536	560	508	732	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	536	560	508	732	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	536	560	508	732	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	1086	1116	806	1105	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	836	902	806	1105	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	1086	1116	806	1105	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	836	902	806	1105	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	1086	1116	806	1105	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	836	902	806	1105	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCC11	Q96J66	1259	1297	1141	1375	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	1259	1297	1141	1375	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	1259	1297	1141	1375	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	536	560	544	551	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	536	560	544	551	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	536	560	544	551	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCC11	Q96J66	836	902	838	838	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	838	838	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	838	838	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	844	844	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	844	844	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	844	844	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	1259	1297	1261	1298	Alternative sequence	ID=VSP_017351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11688999;Dbxref=PMID:11688999
ABCC11	Q96J66	1259	1297	1261	1298	Alternative sequence	ID=VSP_017351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11688999;Dbxref=PMID:11688999
ABCC11	Q96J66	1259	1297	1261	1298	Alternative sequence	ID=VSP_017351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11688999;Dbxref=PMID:11688999
ABCC11	Q96J66	536	560	546	546	Natural variant	ID=VAR_048145;Note=Reduced transport activity%3B no effect on glycoslylation%3B no effect on plasma membrane localization. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19383836,ECO:0000269|PubMed:25896536;Dbxref=dbSNP:rs17822471,PMID:19383836,PMID:25896536
ABCC11	Q96J66	536	560	546	546	Natural variant	ID=VAR_048145;Note=Reduced transport activity%3B no effect on glycoslylation%3B no effect on plasma membrane localization. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19383836,ECO:0000269|PubMed:25896536;Dbxref=dbSNP:rs17822471,PMID:19383836,PMID:25896536
ABCC11	Q96J66	536	560	546	546	Natural variant	ID=VAR_048145;Note=Reduced transport activity%3B no effect on glycoslylation%3B no effect on plasma membrane localization. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19383836,ECO:0000269|PubMed:25896536;Dbxref=dbSNP:rs17822471,PMID:19383836,PMID:25896536
ABCC11	Q96J66	836	902	838	838	Mutagenesis	Note=Loss of N-glycosylation. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	838	838	Mutagenesis	Note=Loss of N-glycosylation. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	838	838	Mutagenesis	Note=Loss of N-glycosylation. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	844	844	Mutagenesis	Note=Loss of N-glycosylation. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	844	844	Mutagenesis	Note=Loss of N-glycosylation. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCC11	Q96J66	836	902	844	844	Mutagenesis	Note=Loss of N-glycosylation. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19383836;Dbxref=PMID:19383836
ABCA10	Q8WWZ4	1016	1054	1	1543	Chain	ID=PRO_0000253572;Note=ATP-binding cassette sub-family A member 10
ABCA10	Q8WWZ4	959	1016	1	1543	Chain	ID=PRO_0000253572;Note=ATP-binding cassette sub-family A member 10
ABCA10	Q8WWZ4	959	1016	985	1005	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA10	Q8WWZ4	1016	1054	1014	1034	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA10	Q8WWZ4	959	1016	1014	1034	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA10	Q8WWZ4	1016	1054	1046	1066	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA10	Q8WWZ4	1016	1054	68	1543	Alternative sequence	ID=VSP_021063;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA10	Q8WWZ4	959	1016	68	1543	Alternative sequence	ID=VSP_021063;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA10	Q8WWZ4	1016	1054	451	1543	Alternative sequence	ID=VSP_021066;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA10	Q8WWZ4	959	1016	451	1543	Alternative sequence	ID=VSP_021066;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA10	Q8WWZ4	1016	1054	453	1543	Alternative sequence	ID=VSP_021067;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ABCA10	Q8WWZ4	959	1016	453	1543	Alternative sequence	ID=VSP_021067;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ABCA12	Q86UK0	1580	1659	1	2595	Chain	ID=PRO_0000093300;Note=ATP-binding cassette sub-family A member 12
ABCA12	Q86UK0	1580	1659	1651	1651	Natural variant	ID=VAR_019602;Note=In ARCI4A. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940568,PMID:12915478
ABCE1	P61221	381	401	1	599	Chain	ID=PRO_0000093316;Note=ATP-binding cassette sub-family E member 1
ABCE1	P61221	506	546	1	599	Chain	ID=PRO_0000093316;Note=ATP-binding cassette sub-family E member 1
ABCE1	P61221	381	401	342	562	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCE1	P61221	506	546	342	562	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCE1	P61221	381	401	379	386	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABL1	P00519	183	274	1	1130	Chain	ID=PRO_0000088050;Note=Tyrosine-protein kinase ABL1
ABL1	P00519	183	274	127	217	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
ABL1	P00519	183	274	242	493	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ABL1	P00519	183	274	248	256	Nucleotide binding	Note=ATP
ABL1	P00519	183	274	271	271	Binding site	Note=ATP
ABL1	P00519	183	274	185	185	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16912036;Dbxref=PMID:16912036
ABL1	P00519	183	274	215	215	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16912036;Dbxref=PMID:16912036
ABL1	P00519	183	274	226	226	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16912036;Dbxref=PMID:16912036
ABL1	P00519	183	274	229	229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42684
ABL1	P00519	183	274	253	253	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ABL1	P00519	183	274	257	257	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ABL1	P00519	183	274	226	226	Natural variant	ID=VAR_079482;Note=In CHDSKM%3B increases kinase activity%3B no effect on protein levels. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28288113;Dbxref=dbSNP:rs1060499547,PMID:28288113
ABL1	P00519	183	274	247	247	Natural variant	ID=VAR_051693;Note=K->R;Dbxref=dbSNP:rs34549764
ABL1	P00519	183	274	184	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DC4
ABL1	P00519	183	274	190	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DC4
ABL1	P00519	183	274	195	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DC4
ABL1	P00519	183	274	209	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DC4
ABL1	P00519	183	274	226	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MO4
ABL1	P00519	183	274	229	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GQG
ABL1	P00519	183	274	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G1T
ABL1	P00519	183	274	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HU9
ABL1	P00519	183	274	242	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HU9
ABL1	P00519	183	274	248	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HU9
ABL1	P00519	183	274	254	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HU9
ABL1	P00519	183	274	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HU9
ABL1	P00519	183	274	266	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HU9
ACTL6A	O96019	315	342	2	429	Chain	ID=PRO_0000089133;Note=Actin-like protein 6A
ACTL6A	O96019	374	403	2	429	Chain	ID=PRO_0000089133;Note=Actin-like protein 6A
ACTL6A	O96019	374	403	377	377	Natural variant	ID=VAR_079729;Note=Probable disease-associated mutation found in a patient with developmental delay%2C speech and learning difficulties%2C dysmorphic features and abnormal digits. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28649782;Dbxref=dbSNP:rs868064163,PMID:28649782
ACTL6A	O96019	315	342	320	320	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
APEH	P13798	202	248	1	732	Chain	ID=PRO_0000122430;Note=Acylamino-acid-releasing enzyme
APEH	P13798	479	507	1	732	Chain	ID=PRO_0000122430;Note=Acylamino-acid-releasing enzyme
APEH	P13798	507	534	1	732	Chain	ID=PRO_0000122430;Note=Acylamino-acid-releasing enzyme
PPP2R5A	Q15172	160	191	2	486	Chain	ID=PRO_0000071448;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
PPP2R5A	Q15172	235	254	2	486	Chain	ID=PRO_0000071448;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
PPP2R5A	Q15172	291	309	2	486	Chain	ID=PRO_0000071448;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
PPP2R5A	Q15172	160	191	176	176	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PGLS	O95336	132	166	2	258	Chain	ID=PRO_0000090078;Note=6-phosphogluconolactonase
PGLS	O95336	166	213	2	258	Chain	ID=PRO_0000090078;Note=6-phosphogluconolactonase
PGLS	O95336	166	213	180	180	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SERPINF2	P08697	21	34	1	27	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1385210,ECO:0000269|PubMed:8484741;Dbxref=PMID:1385210,PMID:8484741
SERPINF2	P08697	21	34	1	27	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1385210,ECO:0000269|PubMed:8484741;Dbxref=PMID:1385210,PMID:8484741
SERPINF2	P08697	21	34	28	39	Propeptide	ID=PRO_0000032511;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14751930,ECO:0000269|PubMed:16223769,ECO:0000269|PubMed:21075,ECO:0000269|PubMed:2440681;Dbxref=PMID:14751930,PMID:16223769,PMID:21075,PMID:2440681
SERPINF2	P08697	21	34	28	39	Propeptide	ID=PRO_0000032511;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14751930,ECO:0000269|PubMed:16223769,ECO:0000269|PubMed:21075,ECO:0000269|PubMed:2440681;Dbxref=PMID:14751930,PMID:16223769,PMID:21075,PMID:2440681
SERPINF2	P08697	170	238	40	491	Chain	ID=PRO_0000032512;Note=Alpha-2-antiplasmin
SERPINF2	P08697	170	238	40	491	Chain	ID=PRO_0000032512;Note=Alpha-2-antiplasmin
SERPINF2	P08697	21	34	27	27	Natural variant	ID=VAR_013252;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583218;Dbxref=PMID:10583218
SERPINF2	P08697	21	34	27	27	Natural variant	ID=VAR_013252;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583218;Dbxref=PMID:10583218
SERPINF2	P08697	21	34	33	33	Natural variant	ID=VAR_013253;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583218;Dbxref=dbSNP:rs2070863,PMID:10583218
SERPINF2	P08697	21	34	33	33	Natural variant	ID=VAR_013253;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583218;Dbxref=dbSNP:rs2070863,PMID:10583218
SERPINF2	P08697	170	238	176	176	Natural variant	ID=VAR_013254;Note=In APLID%3B variant Okinawa%3B probably blocks intracellular transport of alpha-2-plasmin inhibitor. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2572590;Dbxref=PMID:2572590
SERPINF2	P08697	170	238	176	176	Natural variant	ID=VAR_013254;Note=In APLID%3B variant Okinawa%3B probably blocks intracellular transport of alpha-2-plasmin inhibitor. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2572590;Dbxref=PMID:2572590
APBB1IP	Q7Z5R6	151	177	1	666	Chain	ID=PRO_0000181347;Note=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
APBB1IP	Q7Z5R6	300	348	1	666	Chain	ID=PRO_0000181347;Note=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
APBB1IP	Q7Z5R6	348	385	1	666	Chain	ID=PRO_0000181347;Note=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
APBB1IP	Q7Z5R6	385	418	1	666	Chain	ID=PRO_0000181347;Note=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
APBB1IP	Q7Z5R6	151	177	176	263	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
APBB1IP	Q7Z5R6	300	348	310	419	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APBB1IP	Q7Z5R6	348	385	310	419	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APBB1IP	Q7Z5R6	385	418	310	419	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
APBB1IP	Q7Z5R6	151	177	152	155	Compositional bias	Note=Poly-Glu
APBB1IP	Q7Z5R6	151	177	152	172	Alternative sequence	ID=VSP_056542;Note=In isoform 2. EEEEAQAKADKIKLALEKLKE->VSMWDQRWQDHQPLLPITDVP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB1IP	Q7Z5R6	151	177	173	666	Alternative sequence	ID=VSP_056543;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB1IP	Q7Z5R6	300	348	173	666	Alternative sequence	ID=VSP_056543;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB1IP	Q7Z5R6	348	385	173	666	Alternative sequence	ID=VSP_056543;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB1IP	Q7Z5R6	385	418	173	666	Alternative sequence	ID=VSP_056543;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB1IP	Q7Z5R6	385	418	404	404	Natural variant	ID=VAR_050098;Note=T->A;Dbxref=dbSNP:rs34081356
ABLIM3	O94929	348	358	1	683	Chain	ID=PRO_0000075702;Note=Actin-binding LIM protein 3
ABLIM3	O94929	401	434	1	683	Chain	ID=PRO_0000075702;Note=Actin-binding LIM protein 3
ABLIM3	O94929	434	450	1	683	Chain	ID=PRO_0000075702;Note=Actin-binding LIM protein 3
ABLIM3	O94929	348	358	1	683	Chain	ID=PRO_0000075702;Note=Actin-binding LIM protein 3
ABLIM3	O94929	401	434	1	683	Chain	ID=PRO_0000075702;Note=Actin-binding LIM protein 3
ABLIM3	O94929	434	450	1	683	Chain	ID=PRO_0000075702;Note=Actin-binding LIM protein 3
ABLIM3	O94929	348	358	1	514	Alternative sequence	ID=VSP_012126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
ABLIM3	O94929	401	434	1	514	Alternative sequence	ID=VSP_012126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
ABLIM3	O94929	434	450	1	514	Alternative sequence	ID=VSP_012126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
ABLIM3	O94929	348	358	1	514	Alternative sequence	ID=VSP_012126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
ABLIM3	O94929	401	434	1	514	Alternative sequence	ID=VSP_012126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
ABLIM3	O94929	434	450	1	514	Alternative sequence	ID=VSP_012126;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
ABLIM3	O94929	348	358	297	358	Alternative sequence	ID=VSP_012127;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17194709,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17194709,PMID:17974005
ABLIM3	O94929	348	358	297	358	Alternative sequence	ID=VSP_012127;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17194709,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17194709,PMID:17974005
ABLIM3	O94929	401	434	402	450	Alternative sequence	ID=VSP_012128;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABLIM3	O94929	434	450	402	450	Alternative sequence	ID=VSP_012128;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABLIM3	O94929	401	434	402	450	Alternative sequence	ID=VSP_012128;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABLIM3	O94929	434	450	402	450	Alternative sequence	ID=VSP_012128;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABLIM3	O94929	401	434	402	434	Alternative sequence	ID=VSP_012129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17194709,ECO:0000303|PubMed:17974005;Dbxref=PMID:17194709,PMID:17974005
ABLIM3	O94929	434	450	402	434	Alternative sequence	ID=VSP_012129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17194709,ECO:0000303|PubMed:17974005;Dbxref=PMID:17194709,PMID:17974005
ABLIM3	O94929	401	434	402	434	Alternative sequence	ID=VSP_012129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17194709,ECO:0000303|PubMed:17974005;Dbxref=PMID:17194709,PMID:17974005
ABLIM3	O94929	434	450	402	434	Alternative sequence	ID=VSP_012129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17194709,ECO:0000303|PubMed:17974005;Dbxref=PMID:17194709,PMID:17974005
ABCA8	O94911	1143	1165	1	1581	Chain	ID=PRO_0000250677;Note=ATP-binding cassette sub-family A member 8
ABCA8	O94911	972	1008	1	1581	Chain	ID=PRO_0000250677;Note=ATP-binding cassette sub-family A member 8
ABCA8	O94911	313	375	1	1581	Chain	ID=PRO_0000250677;Note=ATP-binding cassette sub-family A member 8
ABCA8	O94911	313	375	299	319	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA8	O94911	313	375	327	347	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA8	O94911	313	375	359	379	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA8	O94911	972	1008	979	999	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA8	O94911	1143	1165	1157	1177	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA8	O94911	1143	1165	267	1581	Alternative sequence	ID=VSP_020703;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA8	O94911	972	1008	267	1581	Alternative sequence	ID=VSP_020703;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA8	O94911	313	375	267	1581	Alternative sequence	ID=VSP_020703;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA8	O94911	313	375	331	331	Natural variant	ID=VAR_027591;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111378;Dbxref=dbSNP:rs4147979,PMID:12111378
ABTB2	Q8N961	922	960	1	1025	Chain	ID=PRO_0000066887;Note=Ankyrin repeat and BTB/POZ domain-containing protein 2
ABTB2	Q8N961	415	465	1	1025	Chain	ID=PRO_0000066887;Note=Ankyrin repeat and BTB/POZ domain-containing protein 2
ACADVL	P49748	46	68	41	655	Chain	ID=PRO_0000000515;Note=Very long-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADVL	P49748	114	159	41	655	Chain	ID=PRO_0000000515;Note=Very long-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADVL	P49748	359	394	41	655	Chain	ID=PRO_0000000515;Note=Very long-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADVL	P49748	394	423	41	655	Chain	ID=PRO_0000000515;Note=Very long-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADVL	P49748	423	444	41	655	Chain	ID=PRO_0000000515;Note=Very long-chain specific acyl-CoA dehydrogenase%2C mitochondrial
ACADVL	P49748	423	444	435	439	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACADVL	P49748	46	68	41	482	Region	Note=Catalytic
ACADVL	P49748	114	159	41	482	Region	Note=Catalytic
ACADVL	P49748	359	394	41	482	Region	Note=Catalytic
ACADVL	P49748	394	423	41	482	Region	Note=Catalytic
ACADVL	P49748	423	444	41	482	Region	Note=Catalytic
ACADVL	P49748	359	394	366	366	Binding site	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACADVL	P49748	46	68	51	51	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P50544
ACADVL	P49748	359	394	372	372	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P50544
ACADVL	P49748	46	68	47	68	Alternative sequence	ID=VSP_007734;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACADVL	P49748	46	68	65	65	Natural variant	ID=VAR_048176;Note=P->L;Dbxref=dbSNP:rs28934585
ACADVL	P49748	114	159	130	130	Natural variant	ID=VAR_000331;Note=In ACADVLD. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10077518,ECO:0000269|PubMed:8554073;Dbxref=PMID:10077518,PMID:8554073
ACADVL	P49748	114	159	158	158	Natural variant	ID=VAR_000332;Note=In ACADVLD. T->N
ACADVL	P49748	114	159	159	159	Natural variant	ID=VAR_000333;Note=In ACADVLD. Q->R;Dbxref=dbSNP:rs746688190
ACADVL	P49748	359	394	359	359	Natural variant	ID=VAR_011990;Note=A->S;Dbxref=dbSNP:rs1051701
ACADVL	P49748	359	394	366	366	Natural variant	ID=VAR_000349;Note=In ACADVLD. R->C;Dbxref=dbSNP:rs771874163
ACADVL	P49748	359	394	366	366	Natural variant	ID=VAR_000350;Note=In ACADVLD. R->H;Dbxref=dbSNP:rs112406105
ACADVL	P49748	359	394	381	381	Natural variant	ID=VAR_000351;Note=In ACADVLD. Missing
ACADVL	P49748	359	394	382	382	Natural variant	ID=VAR_000352;Note=In ACADVLD. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8554073;Dbxref=dbSNP:rs118204015,PMID:8554073
ACADVL	P49748	394	423	405	405	Natural variant	ID=VAR_000353;Note=In ACADVLD. D->H
ACADVL	P49748	423	444	441	441	Natural variant	ID=VAR_000354;Note=In ACADVLD. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10077518;Dbxref=dbSNP:rs2309689,PMID:10077518
ACADVL	P49748	114	159	96	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	114	159	119	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	114	159	130	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	114	159	139	142	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	114	159	148	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	114	159	157	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	359	394	329	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	359	394	373	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	359	394	377	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	394	423	377	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	394	423	412	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	423	444	412	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ACADVL	P49748	423	444	439	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UXW
ABHD11	Q8NFV4	154	211	1	315	Chain	ID=PRO_0000281003;Note=Protein ABHD11
ABHD11	Q8NFV4	154	211	98	315	Alternative sequence	ID=VSP_023927;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12073013;Dbxref=PMID:12073013
ABHD11	Q8NFV4	154	211	102	315	Alternative sequence	ID=VSP_023928;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12073013,ECO:0000303|PubMed:15498874;Dbxref=PMID:12073013,PMID:15498874
ABHD11	Q8NFV4	154	211	153	315	Alternative sequence	ID=VSP_023930;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12073013;Dbxref=PMID:12073013
ABHD11	Q8NFV4	154	211	155	211	Alternative sequence	ID=VSP_046994;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCB8	Q9NUT2	32	48	1	55	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16259955;Dbxref=PMID:16259955
ABCB8	Q9NUT2	153	205	56	735	Chain	ID=PRO_0000000251;Note=ATP-binding cassette sub-family B member 8%2C mitochondrial
ABCB8	Q9NUT2	153	205	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB8	Q9NUT2	153	205	196	216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB8	Q9NUT2	153	205	148	437	Domain	Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
ABCB8	Q9NUT2	32	48	1	187	Alternative sequence	ID=VSP_056744;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCB8	Q9NUT2	153	205	1	187	Alternative sequence	ID=VSP_056744;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCB8	Q9NUT2	32	48	1	153	Alternative sequence	ID=VSP_056745;Note=In isoform 4. MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVV->MRVKLLLPAAPVLPRQHAGAFISGRDSGWPIPRQAATAPPLPDILSCQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCB8	Q9NUT2	153	205	1	153	Alternative sequence	ID=VSP_056745;Note=In isoform 4. MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVV->MRVKLLLPAAPVLPRQHAGAFISGRDSGWPIPRQAATAPPLPDILSCQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABCB8	Q9NUT2	32	48	33	49	Alternative sequence	ID=VSP_000026;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9878413,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334,PMID:9878413
ABCB8	Q9NUT2	153	205	165	165	Natural variant	ID=VAR_035733;Note=In a breast cancer sample%3B somatic mutation. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ABCB8	Q9NUT2	153	205	174	174	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACBD6	Q9BR61	191	221	1	282	Chain	ID=PRO_0000232879;Note=Acyl-CoA-binding domain-containing protein 6
ACBD6	Q9BR61	191	221	191	220	Repeat	Note=ANK 1
ACE	P12821	816	880	30	1306	Chain	ID=PRO_0000028530;Note=Angiotensin-converting enzyme
ACE	P12821	1127	1167	30	1306	Chain	ID=PRO_0000028530;Note=Angiotensin-converting enzyme
ACE	P12821	816	880	30	1232	Chain	ID=PRO_0000028531;Note=Angiotensin-converting enzyme%2C soluble form
ACE	P12821	1127	1167	30	1232	Chain	ID=PRO_0000028531;Note=Angiotensin-converting enzyme%2C soluble form
ACE	P12821	816	880	30	1256	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACE	P12821	1127	1167	30	1256	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACE	P12821	816	880	631	1232	Region	Note=Peptidase M2 2
ACE	P12821	1127	1167	631	1232	Region	Note=Peptidase M2 2
ACE	P12821	816	880	829	829	Binding site	Note=Chloride 3
ACE	P12821	1127	1167	1127	1127	Binding site	Note=Chloride 3
ACE	P12821	1127	1167	1143	1155	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8755737;Dbxref=PMID:8755737
ACE	P12821	1127	1167	1128	1168	Alternative sequence	ID=VSP_054837;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACE	P12821	1127	1167	1137	1145	Alternative sequence	ID=VSP_029932;Note=In isoform Somatic-2. QFHEALCQA->HPFSQHTAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9642152;Dbxref=PMID:9642152
ACE	P12821	1127	1167	1146	1306	Alternative sequence	ID=VSP_029933;Note=In isoform Somatic-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9642152;Dbxref=PMID:9642152
ACE	P12821	816	880	828	828	Natural variant	ID=VAR_034602;Note=M->T;Dbxref=dbSNP:rs13306091
ACE	P12821	816	880	821	826	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	816	880	827	829	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	816	880	834	844	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	816	880	846	864	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	816	880	866	868	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	816	880	879	882	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	1127	1167	1126	1145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	1127	1167	1152	1154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
ACE	P12821	1127	1167	1161	1172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9T
A2M	P01023	1455	1469	24	1474	Chain	ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	951	1010	24	1474	Chain	ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	422	498	24	1474	Chain	ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	368	422	24	1474	Chain	ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	368	422	396	396	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:19159218,PMID:6203908
A2M	P01023	368	422	410	410	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908
A2M	P01023	951	1010	991	991	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:12754519,PMID:16335952,PMID:19159218,PMID:6203908
A2M	P01023	422	498	431	431	Disulfide bond	Note=Interchain (with C-278);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963
A2M	P01023	422	498	470	563	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963
A2M	P01023	951	1010	921	1321	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	1455	1469	1352	1467	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	951	1010	972	975	Cross-link	Note=Isoglutamyl cysteine thioester (Cys-Gln);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908
A2M	P01023	951	1010	972	972	Natural variant	ID=VAR_000013;Note=Probably interferes with the activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1370808;Dbxref=dbSNP:rs1800433,PMID:1370808
A2M	P01023	951	1010	1000	1000	Natural variant	ID=VAR_000014;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:1707161,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245;Dbxref=dbSNP:rs669,PMID:15489334,PMID:15611997,PMID:1707161,PMID:17974005,PMID:2581245
A2M	P01023	1455	1469	1454	1456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BV8
A2M	P01023	1455	1469	1459	1463	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BV8
AAGAB	Q6PD74	150	178	1	315	Chain	ID=PRO_0000058134;Note=Alpha- and gamma-adaptin-binding protein p34
AAK1	Q2M2I8	856	893	1	961	Chain	ID=PRO_0000250578;Note=AP2-associated protein kinase 1
AAK1	Q2M2I8	788	822	1	961	Chain	ID=PRO_0000250578;Note=AP2-associated protein kinase 1
AAK1	Q2M2I8	756	788	1	961	Chain	ID=PRO_0000250578;Note=AP2-associated protein kinase 1
AAK1	Q2M2I8	856	893	823	961	Alternative sequence	ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
AAK1	Q2M2I8	756	788	771	771	Natural variant	ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846
AAK1	Q2M2I8	756	788	777	779	Mutagenesis	Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124
GOT2	P00505	145	199	30	430	Chain	ID=PRO_0000001215;Note=Aspartate aminotransferase%2C mitochondrial
GOT2	P00505	125	145	30	430	Chain	ID=PRO_0000001215;Note=Aspartate aminotransferase%2C mitochondrial
GOT2	P00505	82	125	30	430	Chain	ID=PRO_0000001215;Note=Aspartate aminotransferase%2C mitochondrial
GOT2	P00505	145	199	162	162	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GOT2	P00505	82	125	82	82	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	82	125	90	90	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GOT2	P00505	82	125	90	90	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	82	125	96	96	Modified residue	Note=Nitrated tyrosine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	82	125	96	96	Modified residue	Note=Phosphotyrosine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GOT2	P00505	82	125	107	107	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	82	125	107	107	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	82	125	122	122	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	82	125	122	122	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	125	145	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
GOT2	P00505	145	199	159	159	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GOT2	P00505	145	199	159	159	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	145	199	185	185	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	145	199	185	185	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05202
GOT2	P00505	125	145	83	125	Alternative sequence	ID=VSP_054848;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GOT2	P00505	82	125	83	125	Alternative sequence	ID=VSP_054848;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GOT2	P00505	145	199	188	188	Natural variant	ID=VAR_031710;Note=G->S;Dbxref=dbSNP:rs11076256
GOT2	P00505	82	125	110	111	Sequence conflict	Note=AE->EA;Ontology_term=ECO:0000305;evidence=ECO:0000305
GOT2	P00505	82	125	78	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	82	125	89	91	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	82	125	103	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	82	125	119	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	125	145	126	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	145	199	133	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	125	145	133	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	145	199	153	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	145	199	165	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	145	199	175	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	145	199	184	187	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
GOT2	P00505	145	199	191	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AX8
ABCA6	Q8N139	1176	1202	1	1617	Chain	ID=PRO_0000250672;Note=ATP-binding cassette sub-family A member 6
ABCA6	Q8N139	1136	1176	1	1617	Chain	ID=PRO_0000250672;Note=ATP-binding cassette sub-family A member 6
ABCA6	Q8N139	1004	1040	1	1617	Chain	ID=PRO_0000250672;Note=ATP-binding cassette sub-family A member 6
ABCA6	Q8N139	1004	1040	1007	1027	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA6	Q8N139	1136	1176	1127	1147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA6	Q8N139	1136	1176	1150	1170	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA6	Q8N139	1176	1202	1194	1214	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA6	Q8N139	1176	1202	186	1617	Alternative sequence	ID=VSP_020696;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA6	Q8N139	1136	1176	186	1617	Alternative sequence	ID=VSP_020696;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA6	Q8N139	1004	1040	186	1617	Alternative sequence	ID=VSP_020696;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA6	Q8N139	1176	1202	638	1617	Alternative sequence	ID=VSP_020698;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA6	Q8N139	1136	1176	638	1617	Alternative sequence	ID=VSP_020698;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA6	Q8N139	1004	1040	638	1617	Alternative sequence	ID=VSP_020698;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABHD2	P08910	123	179	1	425	Chain	ID=PRO_0000212457;Note=Monoacylglycerol lipase ABHD2
ABHD2	P08910	241	271	1	425	Chain	ID=PRO_0000212457;Note=Monoacylglycerol lipase ABHD2
ABHD2	P08910	123	179	1	425	Chain	ID=PRO_0000212457;Note=Monoacylglycerol lipase ABHD2
ABHD2	P08910	241	271	1	425	Chain	ID=PRO_0000212457;Note=Monoacylglycerol lipase ABHD2
ABHD2	P08910	123	179	31	425	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABHD2	P08910	241	271	31	425	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABHD2	P08910	123	179	31	425	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABHD2	P08910	241	271	31	425	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABHD2	P08910	123	179	128	382	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD2	P08910	241	271	128	382	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD2	P08910	123	179	128	382	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD2	P08910	241	271	128	382	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABHD2	P08910	123	179	136	136	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
ABHD2	P08910	123	179	136	136	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
ABHD2	P08910	241	271	253	253	Natural variant	ID=VAR_031203;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17851730,PMID:15489334
ABHD2	P08910	241	271	253	253	Natural variant	ID=VAR_031203;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17851730,PMID:15489334
ACBD4	Q8NC06	138	167	1	268	Chain	ID=PRO_0000214032;Note=Acyl-CoA-binding domain-containing protein 4
ACBD4	Q8NC06	138	167	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ACBD4	Q8NC06	138	167	166	166	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNK2	Q07912	964	994	1	1038	Chain	ID=PRO_0000088058;Note=Activated CDC42 kinase 1
TNK2	Q07912	338	387	1	1038	Chain	ID=PRO_0000088058;Note=Activated CDC42 kinase 1
TNK2	Q07912	78	152	1	1038	Chain	ID=PRO_0000088058;Note=Activated CDC42 kinase 1
TNK2	Q07912	338	387	126	385	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TNK2	Q07912	78	152	126	385	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TNK2	Q07912	964	994	958	996	Domain	Note=UBA
TNK2	Q07912	78	152	132	140	Nucleotide binding	Note=ATP
TNK2	Q07912	78	152	1	110	Region	Note=SAM-like domain
TNK2	Q07912	964	994	529	1038	Alternative sequence	ID=VSP_008656;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNK2	Q07912	964	994	965	994	Alternative sequence	ID=VSP_037286;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNK2	Q07912	78	152	99	99	Natural variant	ID=VAR_032794;Note=In an ovarian mucinous carcinoma sample%3B somatic mutation%3B increased autophosphorylation at Y-284%3B increased function in phosphorylation of peptide substrates and WASP%3B no effect on subcellular localization to perinuclear region. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:20110370;Dbxref=dbSNP:rs113498671,PMID:17344846,PMID:20110370
TNK2	Q07912	78	152	99	99	Natural variant	ID=VAR_032795;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3747673,PMID:17344846
TNK2	Q07912	78	152	152	152	Natural variant	ID=VAR_032796;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56161912,PMID:17344846
TNK2	Q07912	338	387	346	346	Natural variant	ID=VAR_032797;Note=In an ovarian endometrioid cancer sample%3B somatic mutation%3B undergoes autoactivation and causes phosphorylation on Y-284 leading to activation of AKT1%3B increased autophosphorylation at Y-284%3B increased function in phosphorylation of peptide substrates and WASP%3B no effect on catalytic activity itself as the purified kinase domain has activity in vitro comparable to wild-type protein%3B no effect on subcellular localization to perinuclear region. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:20110370,ECO:0000269|PubMed:20333297;Dbxref=dbSNP:rs970946035,PMID:17344846,PMID:20110370,PMID:20333297
TNK2	Q07912	78	152	120	120	Mutagenesis	Note=No effect on autophosphorylation at Y-284. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20110370;Dbxref=PMID:20110370
TNK2	Q07912	338	387	365	365	Mutagenesis	Note=Increased autophosphorylation at Y-284. V->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20110370;Dbxref=PMID:20110370
TNK2	Q07912	78	152	138	138	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNK2	Q07912	338	387	304	352	Sequence conflict	Note=TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR->PPWRDISASSSTQFPHAVPCFPTSLLAKLLLRHSVPASSREIKLVSILC;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNK2	Q07912	964	994	353	1038	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNK2	Q07912	338	387	353	1038	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNK2	Q07912	78	152	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZS
TNK2	Q07912	78	152	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	78	152	126	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	78	152	140	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	78	152	148	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EQP
TNK2	Q07912	78	152	152	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	338	387	336	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	338	387	358	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	338	387	372	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
TNK2	Q07912	338	387	378	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HZR
HSD3B7	Q9H2F3	55	107	1	369	Chain	ID=PRO_0000087791;Note=3 beta-hydroxysteroid dehydrogenase type 7
NT5C2	P49902	424	483	1	561	Chain	ID=PRO_0000064389;Note=Cytosolic purine 5'-nucleotidase
NT5C2	P49902	329	386	1	561	Chain	ID=PRO_0000064389;Note=Cytosolic purine 5'-nucleotidase
NT5C2	P49902	229	257	1	561	Chain	ID=PRO_0000064389;Note=Cytosolic purine 5'-nucleotidase
NT5C2	P49902	424	483	1	561	Chain	ID=PRO_0000064389;Note=Cytosolic purine 5'-nucleotidase
NT5C2	P49902	329	386	1	561	Chain	ID=PRO_0000064389;Note=Cytosolic purine 5'-nucleotidase
NT5C2	P49902	229	257	1	561	Chain	ID=PRO_0000064389;Note=Cytosolic purine 5'-nucleotidase
NT5C2	P49902	329	386	351	351	Metal binding	Note=Magnesium
NT5C2	P49902	329	386	351	351	Metal binding	Note=Magnesium
NT5C2	P49902	329	386	354	354	Binding site	Note=Allosteric activator 2
NT5C2	P49902	329	386	354	354	Binding site	Note=Allosteric activator 2
NT5C2	P49902	424	483	436	436	Binding site	Note=Allosteric activator 1%3B via carbonyl oxygen
NT5C2	P49902	424	483	436	436	Binding site	Note=Allosteric activator 1%3B via carbonyl oxygen
NT5C2	P49902	424	483	453	453	Binding site	Note=Allosteric activator 2
NT5C2	P49902	424	483	453	453	Binding site	Note=Allosteric activator 2
NT5C2	P49902	424	483	460	460	Natural variant	ID=VAR_079707;Note=In SPG45%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28884889;Dbxref=PMID:28884889
NT5C2	P49902	424	483	460	460	Natural variant	ID=VAR_079707;Note=In SPG45%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28884889;Dbxref=PMID:28884889
NT5C2	P49902	229	257	231	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	229	257	231	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	229	257	243	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	229	257	243	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	229	257	253	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	229	257	253	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	327	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	327	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	332	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	332	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	343	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	343	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	346	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	346	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	353	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	353	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	358	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	358	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	367	371	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	367	371	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	375	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	375	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	386	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	329	386	386	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	421	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	421	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	440	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	440	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	446	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CQZ
NT5C2	P49902	424	483	446	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CQZ
NT5C2	P49902	424	483	449	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	449	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	459	463	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	459	463	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	465	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
NT5C2	P49902	424	483	465	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JC9
ACACB	O00763	606	660	259	761	Domain	Note=Biotin carboxylation
ACACB	O00763	606	660	259	761	Domain	Note=Biotin carboxylation
ACACB	O00763	606	660	414	609	Domain	Note=ATP-grasp;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
ACACB	O00763	606	660	414	609	Domain	Note=ATP-grasp;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
ACACB	O00763	1674	1726	1695	2025	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
ACACB	O00763	1967	2015	1695	2025	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
ACACB	O00763	1674	1726	1695	2025	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
ACACB	O00763	1967	2015	1695	2025	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
ACACB	O00763	1674	1726	1695	2345	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
ACACB	O00763	1967	2015	1695	2345	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
ACACB	O00763	1674	1726	1695	2345	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
ACACB	O00763	1967	2015	1695	2345	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
ACACB	O00763	1334	1379	1340	1340	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9Q4Z2
ACACB	O00763	1334	1379	1340	1340	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9Q4Z2
ACACB	O00763	1334	1379	1342	1342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ACACB	O00763	1334	1379	1342	1342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ACACB	O00763	1334	1379	1360	1360	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9Q4Z2
ACACB	O00763	1334	1379	1360	1360	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9Q4Z2
ACACB	O00763	606	660	651	651	Natural variant	ID=VAR_031256;Note=A->T;Dbxref=dbSNP:rs2300455
ACACB	O00763	606	660	651	651	Natural variant	ID=VAR_031256;Note=A->T;Dbxref=dbSNP:rs2300455
ACACB	O00763	1334	1379	1340	1340	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACACB	O00763	1334	1379	1340	1340	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACACB	O00763	1413	1449	1425	1425	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACACB	O00763	1413	1449	1425	1425	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACACB	O00763	606	660	600	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	600	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	613	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	613	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	617	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	617	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	635	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HJW
ACACB	O00763	606	660	635	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HJW
ACACB	O00763	606	660	646	653	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	606	660	646	653	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GLK
ACACB	O00763	1674	1726	1698	1700	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FF6
ACACB	O00763	1674	1726	1698	1700	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FF6
ACACB	O00763	1674	1726	1703	1711	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1674	1726	1703	1711	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1674	1726	1717	1719	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1674	1726	1717	1719	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1674	1726	1720	1732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1674	1726	1720	1732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1962	1969	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1962	1969	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1977	1981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1977	1981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1983	1986	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1983	1986	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1987	1990	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1987	1990	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1993	1998	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1993	1998	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1999	2010	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
ACACB	O00763	1967	2015	1999	2010	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TDC
SH3BP5	O60239	296	383	1	455	Chain	ID=PRO_0000064368;Note=SH3 domain-binding protein 5
SH3BP5	O60239	110	165	1	455	Chain	ID=PRO_0000064368;Note=SH3 domain-binding protein 5
SH3BP5	O60239	67	110	1	455	Chain	ID=PRO_0000064368;Note=SH3 domain-binding protein 5
SH3BP5	O60239	67	110	11	67	Compositional bias	Note=Glu-rich
SH3BP5	O60239	296	383	278	421	Compositional bias	Note=Ser-rich
SH3BP5	O60239	296	383	351	351	Modified residue	Note=Phosphoserine%3B by MAPK12 and MAPK9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91Y80
SH3BP5	O60239	296	383	375	375	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z131
SH3BP5	O60239	296	383	376	376	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z131
SH3BP5	O60239	110	165	1	157	Alternative sequence	ID=VSP_042854;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SH3BP5	O60239	67	110	1	157	Alternative sequence	ID=VSP_042854;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SH3BP5	O60239	296	383	347	347	Mutagenesis	Note=Loss of phosphorylation and binding by phospho-JNK%3B when associated with A-349. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12167088;Dbxref=PMID:12167088
SH3BP5	O60239	296	383	349	349	Mutagenesis	Note=Loss of phosphorylation and binding by phospho-JNK%3B when associated with A-347. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12167088;Dbxref=PMID:12167088
ANKRD20A4	Q4UJ75	106	164	1	823	Chain	ID=PRO_0000240835;Note=Ankyrin repeat domain-containing protein 20A4
ANKRD20A4	Q4UJ75	106	164	99	128	Repeat	Note=ANK 2
ANKRD20A4	Q4UJ75	106	164	132	161	Repeat	Note=ANK 3
AAMP	Q13685	226	254	1	434	Chain	ID=PRO_0000050832;Note=Angio-associated migratory cell protein
AAMP	Q13685	91	131	1	434	Chain	ID=PRO_0000050832;Note=Angio-associated migratory cell protein
AAMP	Q13685	91	131	89	129	Repeat	Note=WD 1
AAMP	Q13685	226	254	214	254	Repeat	Note=WD 4
AAMP	Q13685	226	254	250	250	Natural variant	ID=VAR_037061;Note=I->V;Dbxref=dbSNP:rs2305835
ABHD8	Q96I13	254	310	1	439	Chain	ID=PRO_0000281382;Note=Protein ABHD8
ABHD8	Q96I13	254	310	177	279	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACCS	Q96QU6	96	116	1	501	Chain	ID=PRO_0000318071;Note=1-aminocyclopropane-1-carboxylate synthase-like protein 1
ACCS	Q96QU6	218	244	1	501	Chain	ID=PRO_0000318071;Note=1-aminocyclopropane-1-carboxylate synthase-like protein 1
ACCS	Q96QU6	96	116	105	105	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACCS	Q96QU6	218	244	159	501	Alternative sequence	ID=VSP_055801;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACCS	Q96QU6	218	244	221	221	Natural variant	ID=VAR_038685;Note=In a breast cancer sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs35514614,PMID:16959974
PPP2R5E	Q16537	401	434	2	467	Chain	ID=PRO_0000071454;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
PPP2R5E	Q16537	318	358	2	467	Chain	ID=PRO_0000071454;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
PPP2R5E	Q16537	152	183	2	467	Chain	ID=PRO_0000071454;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
PPP2R5E	Q16537	401	434	430	435	Alternative sequence	ID=VSP_054588;Note=In isoform 2. KSDRQR->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HAAO	P46952	210	233	1	286	Chain	ID=PRO_0000064372;Note=3-hydroxyanthranilate 3%2C4-dioxygenase
HAAO	P46952	117	146	1	286	Chain	ID=PRO_0000064372;Note=3-hydroxyanthranilate 3%2C4-dioxygenase
HAAO	P46952	53	81	1	286	Chain	ID=PRO_0000064372;Note=3-hydroxyanthranilate 3%2C4-dioxygenase
HAAO	P46952	117	146	1	160	Region	Note=Domain A (catalytic);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03019
HAAO	P46952	53	81	1	160	Region	Note=Domain A (catalytic);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03019
HAAO	P46952	210	233	178	286	Region	Note=Domain B;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03019
HAAO	P46952	53	81	53	53	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5TK5,ECO:0000255|HAMAP-Rule:MF_03019,ECO:0000269|PubMed:28375145;Dbxref=PMID:28375145
HAAO	P46952	53	81	53	53	Binding site	Note=Substrate;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03019
HAAO	P46952	210	233	148	286	Alternative sequence	ID=VSP_036239;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
HAAO	P46952	210	233	162	286	Natural variant	ID=VAR_080252;Note=In VCRL1%3B strongly reduced 3-hydroxyanthranilate 3%2C4-dioxygenase activity in vitro. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28792876;Dbxref=PMID:28792876
HAAO	P46952	210	233	186	286	Natural variant	ID=VAR_080253;Note=In VCRL1%3B strongly reduced 3-hydroxyanthranilate 3%2C4-dioxygenase activity in vitro. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28792876;Dbxref=PMID:28792876
HAAO	P46952	53	81	53	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	53	81	62	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	53	81	71	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	53	81	81	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	117	146	114	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	117	146	123	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	117	146	137	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	210	233	207	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	210	233	216	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
HAAO	P46952	210	233	228	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNK
SLC3A2	P08195	37	68	1	630	Chain	ID=PRO_0000064383;Note=4F2 cell-surface antigen heavy chain
SLC3A2	P08195	68	99	1	630	Chain	ID=PRO_0000064383;Note=4F2 cell-surface antigen heavy chain
SLC3A2	P08195	482	510	1	630	Chain	ID=PRO_0000064383;Note=4F2 cell-surface antigen heavy chain
SLC3A2	P08195	482	510	206	630	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC3A2	P08195	482	510	506	506	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:19159218,PMID:19349973
SLC3A2	P08195	37	68	1	101	Alternative sequence	ID=VSP_037907;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11557028,ECO:0000303|PubMed:3036867,ECO:0000303|PubMed:3476959,ECO:0000303|PubMed:3480538;Dbxref=PMID:11557028,PMID:3036867,PMID:3476959,PMID:3480538
SLC3A2	P08195	68	99	1	101	Alternative sequence	ID=VSP_037907;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11557028,ECO:0000303|PubMed:3036867,ECO:0000303|PubMed:3476959,ECO:0000303|PubMed:3480538;Dbxref=PMID:11557028,PMID:3036867,PMID:3476959,PMID:3480538
SLC3A2	P08195	37	68	38	99	Alternative sequence	ID=VSP_037908;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC3A2	P08195	68	99	38	99	Alternative sequence	ID=VSP_037908;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC3A2	P08195	68	99	98	98	Alternative sequence	ID=VSP_037909;Note=In isoform 4. V->VTETGFHHVSQADIEFLTSIDPTASASGSAGI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.10
SLC3A2	P08195	482	510	484	486	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DH2
SLC3A2	P08195	482	510	493	495	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DH3
SLC3A2	P08195	482	510	500	502	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DH3
SLC3A2	P08195	482	510	505	507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DH2
SLC3A2	P08195	482	510	509	513	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DH2
NT5E	P21589	187	250	27	549	Chain	ID=PRO_0000000015;Note=5'-nucleotidase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2129526;Dbxref=PMID:2129526
NT5E	P21589	403	453	27	549	Chain	ID=PRO_0000000015;Note=5'-nucleotidase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2129526;Dbxref=PMID:2129526
NT5E	P21589	453	520	27	549	Chain	ID=PRO_0000000015;Note=5'-nucleotidase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2129526;Dbxref=PMID:2129526
NT5E	P21589	453	520	500	506	Region	Note=Substrate binding
NT5E	P21589	187	250	220	220	Metal binding	Note=Zinc 2
NT5E	P21589	187	250	243	243	Metal binding	Note=Zinc 2
NT5E	P21589	187	250	245	245	Binding site	Note=Substrate
NT5E	P21589	403	453	417	417	Binding site	Note=Substrate
NT5E	P21589	403	453	403	403	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
NT5E	P21589	453	520	476	479	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23142347;Dbxref=PMID:23142347
NT5E	P21589	403	453	404	453	Alternative sequence	ID=VSP_043076;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
NT5E	P21589	453	520	404	453	Alternative sequence	ID=VSP_043076;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
NT5E	P21589	187	250	189	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	187	250	196	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	187	250	215	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	187	250	223	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	187	250	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	187	250	250	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	401	404	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	405	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	408	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	420	427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	428	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	440	443	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	403	453	450	459	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	450	459	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	469	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	484	486	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	492	498	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	499	502	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	505	507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	509	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
NT5E	P21589	453	520	516	523	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H2G
AAMDC	Q9H7C9	44	76	1	122	Chain	ID=PRO_0000239814;Note=Mth938 domain-containing protein
AAMDC	Q9H7C9	44	76	1	122	Chain	ID=PRO_0000239814;Note=Mth938 domain-containing protein
AAMDC	Q9H7C9	44	76	6	122	Region	Note=MTH138-like domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
AAMDC	Q9H7C9	44	76	6	122	Region	Note=MTH138-like domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
AAMDC	Q9H7C9	44	76	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AB1
AAMDC	Q9H7C9	44	76	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AB1
AAMDC	Q9H7C9	44	76	51	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AB1
AAMDC	Q9H7C9	44	76	51	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AB1
AAMDC	Q9H7C9	44	76	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AB1
AAMDC	Q9H7C9	44	76	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AB1
YWHAB	P31946	196	228	1	246	Chain	ID=PRO_0000367900;Note=14-3-3 protein beta/alpha
YWHAB	P31946	196	228	1	246	Chain	ID=PRO_0000367900;Note=14-3-3 protein beta/alpha
YWHAB	P31946	196	228	2	246	Chain	ID=PRO_0000000003;Note=14-3-3 protein beta/alpha%2C N-terminally processed
YWHAB	P31946	196	228	2	246	Chain	ID=PRO_0000000003;Note=14-3-3 protein beta/alpha%2C N-terminally processed
YWHAB	P31946	196	228	187	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	187	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	204	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	204	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	210	212	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	210	212	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	213	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
YWHAB	P31946	196	228	213	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N10
PPP2R5B	Q15173	166	197	1	497	Chain	ID=PRO_0000071450;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
PPP2R5B	Q15173	241	260	1	497	Chain	ID=PRO_0000071450;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
PPP2R5B	Q15173	332	372	1	497	Chain	ID=PRO_0000071450;Note=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
PPP2R5B	Q15173	166	197	177	178	Sequence conflict	Note=ES->GA;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP2R5B	Q15173	166	197	181	181	Sequence conflict	Note=F->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP2R5B	Q15173	166	197	184	184	Sequence conflict	Note=S->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
HTR3E	A5X5Y0	78	93	26	456	Chain	ID=PRO_0000312294;Note=5-hydroxytryptamine receptor 3E
HTR3E	A5X5Y0	78	93	26	248	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HTR3E	A5X5Y0	78	93	79	93	Alternative sequence	ID=VSP_029804;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14597179,ECO:0000303|PubMed:19012743;Dbxref=PMID:14597179,PMID:19012743
PGD	P52209	28	88	1	483	Chain	ID=PRO_0000090063;Note=6-phosphogluconate dehydrogenase%2C decarboxylating
PGD	P52209	88	110	1	483	Chain	ID=PRO_0000090063;Note=6-phosphogluconate dehydrogenase%2C decarboxylating
PGD	P52209	403	444	1	483	Chain	ID=PRO_0000090063;Note=6-phosphogluconate dehydrogenase%2C decarboxylating
PGD	P52209	28	88	33	35	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.9
PGD	P52209	28	88	75	77	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.9
PGD	P52209	88	110	103	103	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.9
PGD	P52209	88	110	103	103	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
PGD	P52209	28	88	38	38	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCD0
PGD	P52209	28	88	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCD0
PGD	P52209	28	88	59	59	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGD	P52209	28	88	29	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	28	88	37	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	28	88	45	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	28	88	58	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	28	88	70	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	28	88	79	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	88	110	79	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	88	110	89	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	88	110	97	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	88	110	106	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	403	444	393	416	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	403	444	421	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
PGD	P52209	403	444	440	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GWG
ORM2	P19652	109	145	19	201	Chain	ID=PRO_0000017861;Note=Alpha-1-acid glycoprotein 2
ORM2	P19652	109	145	23	165	Disulfide bond	.
ORM2	P19652	109	145	90	183	Disulfide bond	.
ORM2	P19652	109	145	141	141	Natural variant	ID=VAR_050173;Note=G->R;Dbxref=dbSNP:rs12685968
ORM2	P19652	109	145	125	125	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ORM2	P19652	109	145	105	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3APU
ORM2	P19652	109	145	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3APU
ORM2	P19652	109	145	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3APU
ORM2	P19652	109	145	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3APU
ORM2	P19652	109	145	141	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3APU
ATG16L2	Q8NAA4	237	274	1	619	Chain	ID=PRO_0000337110;Note=Autophagy-related protein 16-2
ATG16L2	Q8NAA4	275	295	1	619	Chain	ID=PRO_0000337110;Note=Autophagy-related protein 16-2
ATG16L2	Q8NAA4	391	415	1	619	Chain	ID=PRO_0000337110;Note=Autophagy-related protein 16-2
ATG16L2	Q8NAA4	557	590	1	619	Chain	ID=PRO_0000337110;Note=Autophagy-related protein 16-2
ATG16L2	Q8NAA4	391	415	378	417	Repeat	Note=WD 2
ATG16L2	Q8NAA4	557	590	546	585	Repeat	Note=WD 6
ATG16L2	Q8NAA4	557	590	589	619	Repeat	Note=WD 7
ATG16L2	Q8NAA4	275	295	276	619	Alternative sequence	ID=VSP_033905;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG16L2	Q8NAA4	391	415	276	619	Alternative sequence	ID=VSP_033905;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG16L2	Q8NAA4	557	590	276	619	Alternative sequence	ID=VSP_033905;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG16L2	Q8NAA4	237	274	256	256	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AAAS	Q9NRG9	149	181	2	546	Chain	ID=PRO_0000050828;Note=Aladin
AAAS	Q9NRG9	149	181	142	180	Repeat	Note=WD 1
AAAS	Q9NRG9	149	181	149	182	Alternative sequence	ID=VSP_043014;Note=In isoform 2. WSSCCLRVFAWHPHTNKFAVALLDDSVRVYNASS->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16022285;Dbxref=PMID:16022285
AAAS	Q9NRG9	149	181	84	546	Natural variant	ID=VAR_080414;Note=In AAAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11159947;Dbxref=PMID:11159947
AAAS	Q9NRG9	149	181	160	160	Natural variant	ID=VAR_012805;Note=In AAAS. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11159947;Dbxref=PMID:11159947
ABCA9	Q8IUA7	1107	1145	1	1624	Chain	ID=PRO_0000250680;Note=ATP-binding cassette sub-family A member 9
ABCA9	Q8IUA7	1013	1049	1	1624	Chain	ID=PRO_0000250680;Note=ATP-binding cassette sub-family A member 9
ABCA9	Q8IUA7	1013	1049	1026	1046	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA9	Q8IUA7	1107	1145	1108	1128	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA9	Q8IUA7	1107	1145	1136	1156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ABCA9	Q8IUA7	1107	1145	267	1624	Alternative sequence	ID=VSP_020705;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA9	Q8IUA7	1013	1049	267	1624	Alternative sequence	ID=VSP_020705;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABCA9	Q8IUA7	1107	1145	268	1624	Alternative sequence	ID=VSP_020706;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCA9	Q8IUA7	1013	1049	268	1624	Alternative sequence	ID=VSP_020706;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCG5	Q9H222	488	549	1	651	Chain	ID=PRO_0000093393;Note=ATP-binding cassette sub-family G member 5
ABCG5	Q9H222	317	378	1	651	Chain	ID=PRO_0000093393;Note=ATP-binding cassette sub-family G member 5
ABCG5	Q9H222	317	378	1	383	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG5	Q9H222	488	549	468	489	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG5	Q9H222	488	549	490	500	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG5	Q9H222	488	549	501	521	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG5	Q9H222	488	549	522	528	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG5	Q9H222	488	549	529	549	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG5	Q9H222	488	549	388	645	Domain	Note=ABC transmembrane type-2
ABCG5	Q9H222	317	378	1	395	Alternative sequence	ID=VSP_055770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ABCG5	Q9H222	488	549	517	517	Natural variant	ID=VAR_033457;Note=T->S;Dbxref=dbSNP:rs17031672
ABCG5	Q9H222	488	549	523	523	Natural variant	ID=VAR_020782;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11668628;Dbxref=dbSNP:rs140899003,PMID:11668628
ABCG5	Q9H222	488	549	540	540	Mutagenesis	Note=Strongly decreases cholesterol secretion into bile. A->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG8	Q9H221	376	403	1	673	Chain	ID=PRO_0000093396;Note=ATP-binding cassette sub-family G member 8
ABCG8	Q9H221	376	403	1	416	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27144356;Dbxref=PMID:27144356
ABCG8	Q9H221	376	403	376	376	Alternative sequence	ID=VSP_000052;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11452359;Dbxref=PMID:11452359
ABCG8	Q9H221	376	403	400	400	Natural variant	ID=VAR_012257;Note=T->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11452359,ECO:0000269|PubMed:11668628,ECO:0000269|PubMed:12111378;Dbxref=dbSNP:rs4148217,PMID:11452359,PMID:11668628,PMID:12111378
ACAP1	Q15027	223	248	1	740	Chain	ID=PRO_0000074209;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 1
ACAP1	Q15027	223	248	1	226	Domain	Note=BAR
ACAP1	Q15027	223	248	1	382	Region	Note=Required for formation of endosomal tubules when overexpressed with PIP5K1C
ACAP1	Q15027	223	248	214	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NSW
PARP8	Q8N3A8	246	287	1	854	Chain	ID=PRO_0000252433;Note=Poly [ADP-ribose] polymerase 8
PARP8	Q8N3A8	556	598	1	854	Chain	ID=PRO_0000252433;Note=Poly [ADP-ribose] polymerase 8
PARP8	Q8N3A8	246	287	1	854	Chain	ID=PRO_0000252433;Note=Poly [ADP-ribose] polymerase 8
PARP8	Q8N3A8	556	598	1	854	Chain	ID=PRO_0000252433;Note=Poly [ADP-ribose] polymerase 8
PARP8	Q8N3A8	556	598	557	598	Alternative sequence	ID=VSP_020970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PARP8	Q8N3A8	556	598	557	598	Alternative sequence	ID=VSP_020970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PARP15	Q460N3	181	257	1	678	Chain	ID=PRO_0000252436;Note=Poly [ADP-ribose] polymerase 15
PARP15	Q460N3	410	479	1	678	Chain	ID=PRO_0000252436;Note=Poly [ADP-ribose] polymerase 15
PARP15	Q460N3	181	257	78	267	Domain	Note=Macro 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
PARP15	Q460N3	410	479	293	464	Domain	Note=Macro 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490
PARP15	Q460N3	410	479	409	413	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3V2B,ECO:0000269|PubMed:23473667;Dbxref=PMID:23473667
PARP15	Q460N3	410	479	449	449	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3V2B,ECO:0000269|PubMed:23473667;Dbxref=PMID:23473667
PARP15	Q460N3	181	257	1	234	Alternative sequence	ID=VSP_020971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PARP15	Q460N3	181	257	235	256	Alternative sequence	ID=VSP_020972;Note=In isoform 2. RPITSPLQEVHFLVYTNDDEGC->MLQRIGLIFLHNIVVVSNCFYF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PARP15	Q460N3	410	479	417	434	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B
PARP15	Q460N3	410	479	442	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B
PARP15	Q460N3	410	479	451	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2B
PCGF6	Q9BYE7	303	332	1	350	Chain	ID=PRO_0000055989;Note=Polycomb group RING finger protein 6
PCGF6	Q9BYE7	270	303	1	350	Chain	ID=PRO_0000055989;Note=Polycomb group RING finger protein 6
PRCP	P42785	307	362	46	496	Chain	ID=PRO_0000027309;Note=Lysosomal Pro-X carboxypeptidase
PRCP	P42785	103	137	46	496	Chain	ID=PRO_0000027309;Note=Lysosomal Pro-X carboxypeptidase
PRCP	P42785	307	362	194	334	Region	Note=SKS domain
PRCP	P42785	307	362	317	317	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:20540760;Dbxref=PMID:19159218,PMID:20540760
PRCP	P42785	307	362	336	336	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20540760;Dbxref=PMID:20540760
PRCP	P42785	307	362	345	345	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20540760;Dbxref=PMID:20540760
PRCP	P42785	307	362	215	372	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20540760;Dbxref=PMID:20540760
PRCP	P42785	307	362	233	310	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20540760;Dbxref=PMID:20540760
PRCP	P42785	307	362	264	343	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20540760;Dbxref=PMID:20540760
PRCP	P42785	103	137	112	112	Natural variant	ID=VAR_020464;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2229437,PMID:14702039
PRCP	P42785	103	137	104	104	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRCP	P42785	103	137	104	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PRCP	P42785	103	137	115	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PRCP	P42785	103	137	132	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PRCP	P42785	307	362	305	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PRCP	P42785	307	362	320	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PRCP	P42785	307	362	342	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PRCP	P42785	307	362	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N2Z
PCSK4	Q6UW60	63	98	26	113	Propeptide	ID=PRO_0000246778;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P29121,ECO:0000255
PCSK4	Q6UW60	63	98	1	513	Alternative sequence	ID=VSP_052097;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCSK4	Q6UW60	63	98	66	66	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCSK4	Q6UW60	63	98	66	66	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCYOX1	Q9UHG3	235	286	28	505	Chain	ID=PRO_0000023298;Note=Prenylcysteine oxidase 1
PDE4C	Q08493	355	410	1	712	Chain	ID=PRO_0000198811;Note=cAMP-specific 3'%2C5'-cyclic phosphodiesterase 4C
PDE4C	Q08493	355	410	1	712	Chain	ID=PRO_0000198811;Note=cAMP-specific 3'%2C5'-cyclic phosphodiesterase 4C
PDE4C	Q08493	355	410	312	641	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE4C	Q08493	355	410	312	641	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE4C	Q08493	355	410	388	392	Nucleotide binding	Note=cAMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDE4C	Q08493	355	410	388	392	Nucleotide binding	Note=cAMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDE4C	Q08493	355	410	388	388	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDE4C	Q08493	355	410	388	388	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDE4C	Q08493	355	410	392	392	Metal binding	Note=Divalent metal cation 1
PDE4C	Q08493	355	410	392	392	Metal binding	Note=Divalent metal cation 1
PDE4C	Q08493	355	410	345	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	345	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	359	362	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	359	362	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	367	379	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	367	379	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	385	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	385	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	390	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	390	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	407	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	407	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	410	412	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE4C	Q08493	355	410	410	412	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QYM
PDE1C	Q14123	630	653	1	709	Chain	ID=PRO_0000198792;Note=Calcium/calmodulin-dependent 3'%2C5'-cyclic nucleotide phosphodiesterase 1C
PDE1C	Q14123	327	360	1	709	Chain	ID=PRO_0000198792;Note=Calcium/calmodulin-dependent 3'%2C5'-cyclic nucleotide phosphodiesterase 1C
PDE1C	Q14123	630	653	1	709	Chain	ID=PRO_0000198792;Note=Calcium/calmodulin-dependent 3'%2C5'-cyclic nucleotide phosphodiesterase 1C
PDE1C	Q14123	327	360	1	709	Chain	ID=PRO_0000198792;Note=Calcium/calmodulin-dependent 3'%2C5'-cyclic nucleotide phosphodiesterase 1C
PDE1C	Q14123	327	360	151	528	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE1C	Q14123	327	360	151	528	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE1C	Q14123	630	653	631	634	Alternative sequence	ID=VSP_004552;Note=In isoform PDE1C1. GTKQ->DSQE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8557689;Dbxref=PMID:8557689
PDE1C	Q14123	630	653	631	634	Alternative sequence	ID=VSP_004552;Note=In isoform PDE1C1. GTKQ->DSQE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8557689;Dbxref=PMID:8557689
PDE1C	Q14123	630	653	635	709	Alternative sequence	ID=VSP_004553;Note=In isoform PDE1C1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8557689;Dbxref=PMID:8557689
PDE1C	Q14123	630	653	635	709	Alternative sequence	ID=VSP_004553;Note=In isoform PDE1C1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8557689;Dbxref=PMID:8557689
PDK2	Q15119	323	361	135	364	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK2	Q15119	323	361	325	330	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16401071;Dbxref=PMID:16401071
PDK2	Q15119	323	361	342	342	Natural variant	ID=VAR_042296;Note=In a glioblastoma multiforme sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs17855787,PMID:15489334,PMID:17344846
PDK2	Q15119	87	110	79	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PDK2	Q15119	87	110	97	100	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PDK2	Q15119	87	110	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M4K
PDK2	Q15119	87	110	106	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PDK2	Q15119	323	361	323	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V26
PDK2	Q15119	323	361	326	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M4P
PDK2	Q15119	323	361	329	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PDK2	Q15119	323	361	343	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PDK2	Q15119	323	361	350	352	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PDK2	Q15119	323	361	353	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J71
PEF1	Q9UBV8	160	208	1	284	Chain	ID=PRO_0000247045;Note=Peflin
PEF1	Q9UBV8	108	160	1	284	Chain	ID=PRO_0000247045;Note=Peflin
PEF1	Q9UBV8	108	160	101	109	Repeat	Note=9;Ontology_term=ECO:0000305;evidence=ECO:0000305
PEF1	Q9UBV8	108	160	114	149	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PEF1	Q9UBV8	160	208	155	183	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PEF1	Q9UBV8	108	160	155	183	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PEF1	Q9UBV8	160	208	181	216	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PEF1	Q9UBV8	108	160	127	138	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PEF1	Q9UBV8	160	208	194	205	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PEF1	Q9UBV8	108	160	21	109	Region	Note=9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PEF1	Q9UBV8	160	208	204	284	Region	Note=Required for interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11883899;Dbxref=PMID:11883899
PEF1	Q9UBV8	108	160	137	137	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27716508;Dbxref=PMID:27716508
PEF1	Q9UBV8	108	160	137	137	Mutagenesis	Note=Decreased ubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27716508;Dbxref=PMID:27716508
PEF1	Q9UBV8	160	208	165	165	Mutagenesis	Note=Does not affect ubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27716508;Dbxref=PMID:27716508
PEF1	Q9UBV8	160	208	167	167	Mutagenesis	Note=Does not affect ubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27716508;Dbxref=PMID:27716508
PELI1	Q96FA3	67	101	1	418	Chain	ID=PRO_0000194172;Note=E3 ubiquitin-protein ligase pellino homolog 1
PELI1	Q96FA3	67	101	13	200	Domain	Note=FHA%3B atypical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HAT8
PELI1	Q96FA3	67	101	100	100	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPL	O60437	771	799	1	1756	Chain	ID=PRO_0000078149;Note=Periplakin
PPL	O60437	188	202	1	1756	Chain	ID=PRO_0000078149;Note=Periplakin
PPL	O60437	771	799	733	861	Repeat	Note=Spectrin 4
PPL	O60437	188	202	188	389	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PPL	O60437	771	799	585	820	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PER2	O15055	472	514	1	1255	Chain	ID=PRO_0000162630;Note=Period circadian protein homolog 2
PER2	O15055	472	514	480	484	Region	Note=Important for protein stability;Ontology_term=ECO:0000250;evidence=ECO:0000250
PER2	O15055	472	514	510	513	Compositional bias	Note=Poly-Arg
PER2	O15055	472	514	405	1255	Alternative sequence	ID=VSP_021654;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
MPO	P05164	540	597	49	745	Chain	ID=PRO_0000023651;Note=89 kDa myeloperoxidase
MPO	P05164	540	597	155	745	Chain	ID=PRO_0000023653;Note=84 kDa myeloperoxidase
MPO	P05164	540	597	165	745	Chain	ID=PRO_0000023654;Note=Myeloperoxidase
MPO	P05164	540	597	279	745	Chain	ID=PRO_0000023656;Note=Myeloperoxidase heavy chain
MPO	P05164	540	597	569	569	Natural variant	ID=VAR_015379;Note=In MPOD%3B suppress post-translational processing. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7904599,ECO:0000269|PubMed:8142659,ECO:0000269|PubMed:8621627;Dbxref=dbSNP:rs119468010,PMID:7904599,PMID:8142659,PMID:8621627
MPO	P05164	540	597	544	552	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MFA
MPO	P05164	540	597	553	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MFA
MPO	P05164	540	597	566	569	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MFA
MPO	P05164	540	597	573	576	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MFA
MPO	P05164	540	597	577	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MFA
MPO	P05164	540	597	583	593	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MFA
PEX5	P50542	49	61	1	639	Chain	ID=PRO_0000106305;Note=Peroxisomal targeting signal 1 receptor
PEX5	P50542	214	251	1	639	Chain	ID=PRO_0000106305;Note=Peroxisomal targeting signal 1 receptor
PEX5	P50542	49	61	1	639	Chain	ID=PRO_0000106305;Note=Peroxisomal targeting signal 1 receptor
PEX5	P50542	214	251	1	639	Chain	ID=PRO_0000106305;Note=Peroxisomal targeting signal 1 receptor
PEX5	P50542	214	251	215	251	Alternative sequence	ID=VSP_021880;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7719337,ECO:0000303|PubMed:7790377;Dbxref=PMID:14702039,PMID:7719337,PMID:7790377
PEX5	P50542	214	251	215	251	Alternative sequence	ID=VSP_021880;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7719337,ECO:0000303|PubMed:7790377;Dbxref=PMID:14702039,PMID:7719337,PMID:7790377
PEX5	P50542	49	61	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXU
PEX5	P50542	49	61	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXU
PHF21A	Q96BD5	483	535	1	680	Chain	ID=PRO_0000226767;Note=PHD finger protein 21A
PHF21A	Q96BD5	331	364	1	680	Chain	ID=PRO_0000226767;Note=PHD finger protein 21A
PHF21A	Q96BD5	233	331	1	680	Chain	ID=PRO_0000226767;Note=PHD finger protein 21A
PHF21A	Q96BD5	204	233	1	680	Chain	ID=PRO_0000226767;Note=PHD finger protein 21A
PHF21A	Q96BD5	120	204	1	680	Chain	ID=PRO_0000226767;Note=PHD finger protein 21A
PHF21A	Q96BD5	483	535	488	535	Zinc finger	Note=PHD-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
PHF21A	Q96BD5	483	535	486	680	Region	Note=Required for transcriptional repression
PHF21A	Q96BD5	331	364	350	350	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHF21A	Q96BD5	204	233	204	204	Alternative sequence	ID=VSP_017448;Note=In isoform 2 and isoform 3. L->LQ;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:12032298,ECO:0000303|PubMed:14702039;Dbxref=PMID:11214970,PMID:12032298,PMID:14702039
PHF21A	Q96BD5	120	204	204	204	Alternative sequence	ID=VSP_017448;Note=In isoform 2 and isoform 3. L->LQ;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:12032298,ECO:0000303|PubMed:14702039;Dbxref=PMID:11214970,PMID:12032298,PMID:14702039
PHF21A	Q96BD5	483	535	429	483	Alternative sequence	ID=VSP_017449;Note=In isoform 2. GRPPKYNAVLGFGALTPTSPQSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTD->ANEEHWPK;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:12032298,ECO:0000303|PubMed:14702039;Dbxref=PMID:11214970,PMID:12032298,PMID:14702039
PHF21A	Q96BD5	331	364	347	347	Natural variant	ID=VAR_025515;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12032298,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3736508,PMID:12032298,PMID:14702039
PHF21A	Q96BD5	483	535	492	494	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PUY
PHF21A	Q96BD5	483	535	504	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PUY
PHF21A	Q96BD5	483	535	512	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PUY
PHF21A	Q96BD5	483	535	515	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PUY
PHF21A	Q96BD5	483	535	530	538	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PUY
POU2F3	Q9UKI9	148	209	1	436	Chain	ID=PRO_0000100717;Note=POU domain%2C class 2%2C transcription factor 3
POU2F3	Q9UKI9	302	356	1	436	Chain	ID=PRO_0000100717;Note=POU domain%2C class 2%2C transcription factor 3
POU2F3	Q9UKI9	148	209	183	257	Domain	Note=POU-specific;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00530
POU2F3	Q9UKI9	302	356	281	340	DNA binding	Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
POU2F3	Q9UKI9	302	356	354	425	Compositional bias	Note=Ser-rich
POU2F3	Q9UKI9	148	209	152	152	Natural variant	ID=VAR_031618;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10473598,ECO:0000269|PubMed:14702039,ECO:0000269|Ref.2;Dbxref=dbSNP:rs7110845,PMID:10473598,PMID:14702039
POU2F3	Q9UKI9	302	356	351	351	Sequence conflict	Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRD5A3	Q9H8P0	121	187	1	318	Chain	ID=PRO_0000317703;Note=Polyprenol reductase
SRD5A3	Q9H8P0	187	232	1	318	Chain	ID=PRO_0000317703;Note=Polyprenol reductase
SRD5A3	Q9H8P0	121	187	118	138	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SRD5A3	Q9H8P0	121	187	139	157	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SRD5A3	Q9H8P0	121	187	158	178	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SRD5A3	Q9H8P0	121	187	179	194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SRD5A3	Q9H8P0	187	232	179	194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SRD5A3	Q9H8P0	187	232	195	215	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SRD5A3	Q9H8P0	187	232	216	260	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
POP5	Q969H6	104	132	1	163	Chain	ID=PRO_0000239007;Note=Ribonuclease P/MRP protein subunit POP5
POP5	Q969H6	54	104	1	163	Chain	ID=PRO_0000239007;Note=Ribonuclease P/MRP protein subunit POP5
POP5	Q969H6	104	132	55	104	Alternative sequence	ID=VSP_042733;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POP5	Q969H6	54	104	55	104	Alternative sequence	ID=VSP_042733;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POP5	Q969H6	54	104	99	99	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
POP5	Q969H6	54	104	102	102	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PQLC3	Q8N755	158	172	20	202	Chain	ID=PRO_0000232512;Note=PQ-loop repeat-containing protein 3
PQLC3	Q8N755	158	172	171	191	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PQLC3	Q8N755	158	172	159	172	Alternative sequence	ID=VSP_054623;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF40B	Q6NWY9	94	131	1	871	Chain	ID=PRO_0000309282;Note=Pre-mRNA-processing factor 40 homolog B
PRPF40B	Q6NWY9	312	366	1	871	Chain	ID=PRO_0000309282;Note=Pre-mRNA-processing factor 40 homolog B
PRPF40B	Q6NWY9	652	684	1	871	Chain	ID=PRO_0000309282;Note=Pre-mRNA-processing factor 40 homolog B
PRPF40B	Q6NWY9	94	131	92	125	Domain	Note=WW 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
PRPF40B	Q6NWY9	312	366	276	330	Domain	Note=FF 1
PRPF40B	Q6NWY9	312	366	340	397	Domain	Note=FF 2
PRPF40B	Q6NWY9	652	684	625	682	Domain	Note=FF 6
PRPF40B	Q6NWY9	94	131	77	200	Alternative sequence	ID=VSP_029120;Note=In isoform 4. TAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQSKESRWTRPKDLDDLEVLVKQEAAGKQQQQLPQTLQPQPPQPQPD->VSTRGQQVAGSALQSRESDLECRTMTSILSLFSSHPPRSPAALPTLKSFSPAMYSALLVSHSSPKAYTFSCYSRALSSSLKEHTYPHRATHCGHMNIVLHILFVPRRVSSTWGSCCAFLCYRSV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF40B	Q6NWY9	312	366	201	871	Alternative sequence	ID=VSP_029121;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF40B	Q6NWY9	652	684	201	871	Alternative sequence	ID=VSP_029121;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRDM16	Q9HAZ2	146	191	1	1276	Chain	ID=PRO_0000047773;Note=PR domain zinc finger protein 16
PRDM16	Q9HAZ2	146	191	82	211	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
PRDM16	Q9HAZ2	146	191	1	184	Alternative sequence	ID=VSP_038063;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRDM16	Q9HAZ2	146	191	191	191	Alternative sequence	ID=VSP_038064;Note=In isoform 3. Q->QV;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PRDM16	Q9HAZ2	146	191	153	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N1I
PRDM16	Q9HAZ2	146	191	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N1I
PRDM16	Q9HAZ2	146	191	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N1I
PRDM16	Q9HAZ2	146	191	178	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N1I
PRDM16	Q9HAZ2	146	191	183	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N1I
PRDM16	Q9HAZ2	146	191	191	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N1I
CFP	P27918	255	313	28	469	Chain	ID=PRO_0000035863;Note=Properdin
CFP	P27918	255	313	28	469	Chain	ID=PRO_0000035863;Note=Properdin
CFP	P27918	255	313	193	255	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	193	255	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	257	313	Domain	Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	257	313	Domain	Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	260	260	Glycosylation	Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10878002;Dbxref=PMID:10878002
CFP	P27918	255	313	260	260	Glycosylation	Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10878002;Dbxref=PMID:10878002
CFP	P27918	255	313	263	263	Glycosylation	Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10878002;Dbxref=PMID:10878002
CFP	P27918	255	313	263	263	Glycosylation	Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10878002;Dbxref=PMID:10878002
CFP	P27918	255	313	272	272	Glycosylation	Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12096136;Dbxref=PMID:12096136
CFP	P27918	255	313	272	272	Glycosylation	Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12096136;Dbxref=PMID:12096136
CFP	P27918	255	313	269	306	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	269	306	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	273	312	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	273	312	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	284	296	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	284	296	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
CFP	P27918	255	313	298	298	Natural variant	ID=VAR_013139;Note=In PFD%3B type I. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10909851;Dbxref=dbSNP:rs28935480,PMID:10909851
CFP	P27918	255	313	298	298	Natural variant	ID=VAR_013139;Note=In PFD%3B type I. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10909851;Dbxref=dbSNP:rs28935480,PMID:10909851
PROS1	P07225	385	441	42	676	Chain	ID=PRO_0000022120;Note=Vitamin K-dependent protein S
PROS1	P07225	156	200	42	676	Chain	ID=PRO_0000022120;Note=Vitamin K-dependent protein S
PROS1	P07225	86	115	42	676	Chain	ID=PRO_0000022120;Note=Vitamin K-dependent protein S
PROS1	P07225	86	115	42	87	Domain	Note=Gla;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00463
PROS1	P07225	156	200	157	200	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
PROS1	P07225	385	441	299	475	Domain	Note=Laminin G-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
PROS1	P07225	86	115	88	116	Region	Note=Thrombin-sensitive
PROS1	P07225	156	200	161	175	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PROS1	P07225	156	200	171	184	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PROS1	P07225	156	200	186	199	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PROS1	P07225	86	115	87	87	Natural variant	ID=VAR_046812;Note=In THPH5. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15238143;Dbxref=dbSNP:rs557733421,PMID:15238143
PROS1	P07225	86	115	88	88	Natural variant	ID=VAR_046813;Note=In THPH5. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712227;Dbxref=PMID:15712227
PROS1	P07225	86	115	90	90	Natural variant	ID=VAR_046814;Note=In THPH5%3B produces around 50%25 of PROS1 levels compared to wild-type%3B has impaired secretion%3B intracellular degradation of unsecreted material is found. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11858485;Dbxref=dbSNP:rs765935815,PMID:11858485
PROS1	P07225	86	115	90	90	Natural variant	ID=VAR_046815;Note=In THPH5. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7803790;Dbxref=dbSNP:rs200886866,PMID:7803790
PROS1	P07225	86	115	95	95	Natural variant	ID=VAR_046816;Note=In THPH5. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8943854;Dbxref=dbSNP:rs144526169,PMID:8943854
PROS1	P07225	86	115	95	95	Natural variant	ID=VAR_046817;Note=In THPH5%3B the activated protein cofactor activity is inhibited by C4BPB with a dose dependency similar to that of wild-type PROS1. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927129,ECO:0000269|PubMed:9241758;Dbxref=PMID:11927129,PMID:9241758
PROS1	P07225	86	115	98	98	Natural variant	ID=VAR_046818;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10790208;Dbxref=dbSNP:rs142805170,PMID:10790208
PROS1	P07225	86	115	101	101	Natural variant	ID=VAR_046819;Note=In THPH5. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632031;Dbxref=dbSNP:rs778731080,PMID:12632031
PROS1	P07225	86	115	111	111	Natural variant	ID=VAR_046820;Note=In THPH5. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8765219;Dbxref=PMID:8765219
PROS1	P07225	156	200	157	157	Natural variant	ID=VAR_046825;Note=In THPH5. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8765219;Dbxref=dbSNP:rs751090951,PMID:8765219
PROS1	P07225	156	200	161	161	Natural variant	ID=VAR_046826;Note=In THPH5. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8765219;Dbxref=PMID:8765219
PROS1	P07225	156	200	166	166	Natural variant	ID=VAR_046827;Note=In THPH5. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10706858;Dbxref=PMID:10706858
PROS1	P07225	156	200	168	168	Natural variant	ID=VAR_046828;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632031;Dbxref=dbSNP:rs144430063,PMID:12632031
PROS1	P07225	156	200	175	175	Natural variant	ID=VAR_046829;Note=In THPH5. C->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10613647,ECO:0000269|PubMed:15712227;Dbxref=PMID:10613647,PMID:15712227
PROS1	P07225	156	200	186	186	Natural variant	ID=VAR_046830;Note=In THPH5. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8781426,ECO:0000269|PubMed:8943854;Dbxref=dbSNP:rs779391826,PMID:8781426,PMID:8943854
PROS1	P07225	156	200	196	196	Natural variant	ID=VAR_005566;Note=In THPH5%3B Tokushima%3B the specific activity decreases to 58%25 of that of the wild-type PROS1%3B the activated protein cofactor activity is inhibited by C4BPB with a dose dependency similar to that of wild-type PROS1. K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927129,ECO:0000269|PubMed:15238143,ECO:0000269|PubMed:8298131;Dbxref=dbSNP:rs121918474,PMID:11927129,PMID:15238143,PMID:8298131
PROS1	P07225	385	441	385	385	Natural variant	ID=VAR_046856;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7803790;Dbxref=dbSNP:rs767653920,PMID:7803790
PROS1	P07225	385	441	390	390	Natural variant	ID=VAR_046857;Note=In THPH5. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11776305;Dbxref=PMID:11776305
PRPS1	P60891	102	135	2	318	Chain	ID=PRO_0000141071;Note=Ribose-phosphate pyrophosphokinase 1
PRPS1	P60891	102	135	128	128	Metal binding	Note=Magnesium;Ontology_term=ECO:0000255;evidence=ECO:0000255
PRPS1	P60891	102	135	130	130	Metal binding	Note=Magnesium;Ontology_term=ECO:0000255;evidence=ECO:0000255
PRPS1	P60891	102	135	130	130	Binding site	Note=ATP
PRPS1	P60891	102	135	114	114	Natural variant	ID=VAR_004163;Note=In PRPS1 superactivity. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7593598,ECO:0000269|Ref.12;Dbxref=dbSNP:rs137852540,PMID:7593598
PRPS1	P60891	102	135	115	115	Natural variant	ID=VAR_036942;Note=In CMTX5. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17701900;Dbxref=dbSNP:rs80338732,PMID:17701900
PRPS1	P60891	102	135	129	129	Natural variant	ID=VAR_016045;Note=In PRPS1 superactivity. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7593598;Dbxref=dbSNP:rs137852543,PMID:7593598
PRPS1	P60891	102	135	133	133	Natural variant	ID=VAR_036943;Note=In ARTS. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17701896;Dbxref=dbSNP:rs80338675,PMID:17701896
PRPS1	P60891	102	135	132	132	Mutagenesis	Note=Reduces catalytic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16939420;Dbxref=PMID:16939420
PRPS1	P60891	102	135	132	132	Mutagenesis	Note=No effect on catalytic activity. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16939420;Dbxref=PMID:16939420
PRPS1	P60891	102	135	122	122	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRPS1	P60891	102	135	101	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H06
PRPS1	P60891	102	135	108	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S5J
PRPS1	P60891	102	135	122	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S5J
PRPS1	P60891	102	135	132	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S5J
PSMC2	P35998	197	252	2	433	Chain	ID=PRO_0000084709;Note=26S proteasome regulatory subunit 7
PSMC2	P35998	197	252	2	433	Chain	ID=PRO_0000084709;Note=26S proteasome regulatory subunit 7
PSMC2	P35998	197	252	216	223	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSMC2	P35998	197	252	216	223	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
PRR11	Q96HE9	93	134	1	360	Chain	ID=PRO_0000243943;Note=Proline-rich protein 11
PRR11	Q96HE9	215	248	1	360	Chain	ID=PRO_0000243943;Note=Proline-rich protein 11
NPEPPS	P55786	180	216	1	919	Chain	ID=PRO_0000095116;Note=Puromycin-sensitive aminopeptidase
NPEPPS	P55786	420	455	1	919	Chain	ID=PRO_0000095116;Note=Puromycin-sensitive aminopeptidase
NPEPPS	P55786	746	765	1	919	Chain	ID=PRO_0000095116;Note=Puromycin-sensitive aminopeptidase
NPEPPS	P55786	853	869	1	919	Chain	ID=PRO_0000095116;Note=Puromycin-sensitive aminopeptidase
NPEPPS	P55786	180	216	180	180	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
NPEPPS	P55786	420	455	438	438	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
NPEPPS	P55786	180	216	181	216	Alternative sequence	ID=VSP_056447;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NPEPPS	P55786	420	455	438	438	Mutagenesis	Note=Reduces catalytic activity by 1%2C000-fold to 2%2C500-fold. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12729622;Dbxref=PMID:12729622
NPEPPS	P55786	180	216	184	184	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP210	Q8TEM1	1228	1281	27	1887	Chain	ID=PRO_0000236046;Note=Nuclear pore membrane glycoprotein 210
NUP210	Q8TEM1	1076	1097	27	1887	Chain	ID=PRO_0000236046;Note=Nuclear pore membrane glycoprotein 210
NUP210	Q8TEM1	477	529	27	1887	Chain	ID=PRO_0000236046;Note=Nuclear pore membrane glycoprotein 210
NUP210	Q8TEM1	1228	1281	27	1808	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP210	Q8TEM1	1076	1097	27	1808	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP210	Q8TEM1	477	529	27	1808	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP210	Q8TEM1	1076	1097	1078	1151	Domain	Note=BIG2;Ontology_term=ECO:0000255;evidence=ECO:0000255
NUP210	Q8TEM1	477	529	486	491	Compositional bias	Note=Poly-Ser
NUP210	Q8TEM1	477	529	484	484	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NUP210	Q8TEM1	1228	1281	968	1887	Alternative sequence	ID=VSP_018568;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
NUP210	Q8TEM1	1076	1097	968	1887	Alternative sequence	ID=VSP_018568;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
NUP210	Q8TEM1	1076	1097	1096	1096	Natural variant	ID=VAR_028152;Note=M->I;Dbxref=dbSNP:rs2271505
POU2F2	P09086	62	101	1	479	Chain	ID=PRO_0000100714;Note=POU domain%2C class 2%2C transcription factor 2
POC5	Q8NA72	469	528	1	575	Chain	ID=PRO_0000281908;Note=Centrosomal protein POC5
POC5	Q8NA72	230	265	1	575	Chain	ID=PRO_0000281908;Note=Centrosomal protein POC5
POC5	Q8NA72	74	102	1	575	Chain	ID=PRO_0000281908;Note=Centrosomal protein POC5
POC5	Q8NA72	230	265	231	262	Repeat	Note=Centrin-binding (CBR) 2
POC5	Q8NA72	230	265	263	295	Repeat	Note=Centrin-binding (CBR) 3
POC5	Q8NA72	74	102	1	117	Alternative sequence	ID=VSP_024098;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POC5	Q8NA72	469	528	470	528	Alternative sequence	ID=VSP_024100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POC5	Q8NA72	74	102	85	85	Natural variant	ID=VAR_031325;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs17672542,PMID:14702039
RELB	Q01201	251	295	1	579	Chain	ID=PRO_0000205173;Note=Transcription factor RelB
RELB	Q01201	330	402	1	579	Chain	ID=PRO_0000205173;Note=Transcription factor RelB
RELB	Q01201	425	451	1	579	Chain	ID=PRO_0000205173;Note=Transcription factor RelB
RELB	Q01201	251	295	125	440	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
RELB	Q01201	330	402	125	440	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
RELB	Q01201	425	451	125	440	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
RELB	Q01201	425	451	433	438	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELB	Q01201	330	402	396	396	Natural variant	ID=VAR_051782;Note=T->M;Dbxref=dbSNP:rs2230682
RELB	Q01201	330	402	397	579	Natural variant	ID=VAR_079201;Note=In IMD53. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26385063;Dbxref=PMID:26385063
RELB	Q01201	425	451	397	579	Natural variant	ID=VAR_079201;Note=In IMD53. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26385063;Dbxref=PMID:26385063
PQLC1	Q8N2U9	112	130	1	271	Chain	ID=PRO_0000282430;Note=PQ-loop repeat-containing protein 1
PQLC1	Q8N2U9	112	130	113	130	Alternative sequence	ID=VSP_024145;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PQLC1	Q8N2U9	112	130	114	132	Alternative sequence	ID=VSP_043275;Note=In isoform 3. ADSKDEEVKVAPRRSFLDF->SRWCSCGPVVTPSRRPTSC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PREB	Q9HCU5	251	308	1	417	Chain	ID=PRO_0000051154;Note=Prolactin regulatory element-binding protein
PREB	Q9HCU5	182	209	1	417	Chain	ID=PRO_0000051154;Note=Prolactin regulatory element-binding protein
PREB	Q9HCU5	251	308	1	388	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PREB	Q9HCU5	182	209	1	388	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PREB	Q9HCU5	182	209	127	183	Repeat	Note=WD 3
PREB	Q9HCU5	182	209	187	224	Repeat	Note=WD 4
PREB	Q9HCU5	251	308	230	287	Repeat	Note=WD 5
PREB	Q9HCU5	251	308	291	329	Repeat	Note=WD 6
PREB	Q9HCU5	182	209	177	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	182	209	183	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	182	209	188	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	182	209	199	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	182	209	206	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	251	308	245	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	251	308	262	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	251	308	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	251	308	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	251	308	292	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PREB	Q9HCU5	251	308	303	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TF2
PGR	P06401	635	737	1	933	Chain	ID=PRO_0000053693;Note=Progesterone receptor
PGR	P06401	596	635	1	933	Chain	ID=PRO_0000053693;Note=Progesterone receptor
PGR	P06401	635	737	679	913	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
PGR	P06401	635	737	567	639	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
PGR	P06401	596	635	567	639	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
PGR	P06401	596	635	603	627	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
PGR	P06401	635	737	687	933	Region	Note=AF2%3B mediates transcriptional activation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1587864;Dbxref=PMID:1587864
PGR	P06401	635	737	676	676	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11110801;Dbxref=PMID:11110801
PGR	P06401	635	737	17	635	Alternative sequence	ID=VSP_047455;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12644308;Dbxref=PMID:12644308
PGR	P06401	596	635	17	635	Alternative sequence	ID=VSP_047455;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12644308;Dbxref=PMID:12644308
PGR	P06401	635	737	636	737	Alternative sequence	ID=VSP_053543;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
PGR	P06401	596	635	625	625	Natural variant	ID=VAR_014627;Note=R->I;Dbxref=dbSNP:rs2020874
PGR	P06401	635	737	651	651	Natural variant	ID=VAR_019228;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs11571222
PGR	P06401	635	737	660	660	Natural variant	ID=VAR_016118;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12644308,ECO:0000269|PubMed:3551956,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1042838,PMID:12644308,PMID:3551956
PGR	P06401	596	635	585	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CC0
PGR	P06401	596	635	604	607	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CC0
PGR	P06401	596	635	613	618	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CC0
PGR	P06401	596	635	620	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CC0
PGR	P06401	635	737	686	694	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQN
PGR	P06401	635	737	711	735	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SQN
PRDM4	Q9UKN5	536	641	1	801	Chain	ID=PRO_0000047760;Note=PR domain zinc finger protein 4
PRDM4	Q9UKN5	110	375	1	801	Chain	ID=PRO_0000047760;Note=PR domain zinc finger protein 4
PRDM4	Q9UKN5	48	110	1	801	Chain	ID=PRO_0000047760;Note=PR domain zinc finger protein 4
PRDM4	Q9UKN5	536	641	545	566	Zinc finger	Note=C2H2-type 1%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM4	Q9UKN5	536	641	618	640	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM4	Q9UKN5	536	641	580	580	Sequence conflict	Note=H->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRDM4	Q9UKN5	536	641	608	608	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRDM4	Q9UKN5	110	375	374	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L9Z
PRDM4	Q9UKN5	536	641	531	536	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DB5
PRICKLE1	Q96MT3	128	196	1	828	Chain	ID=PRO_0000075889;Note=Prickle-like protein 1
PRICKLE1	Q96MT3	128	196	1	828	Chain	ID=PRO_0000075889;Note=Prickle-like protein 1
PRICKLE1	Q96MT3	128	196	1	828	Chain	ID=PRO_0000075889;Note=Prickle-like protein 1
PRICKLE1	Q96MT3	128	196	1	828	Chain	ID=PRO_0000075889;Note=Prickle-like protein 1
PRICKLE1	Q96MT3	128	196	1	828	Chain	ID=PRO_0000075889;Note=Prickle-like protein 1
PRICKLE1	Q96MT3	128	196	124	189	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	124	189	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	124	189	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	124	189	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	124	189	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	189	249	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	189	249	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	189	249	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	189	249	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	189	249	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE1	Q96MT3	128	196	144	144	Natural variant	ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947
PRICKLE1	Q96MT3	128	196	144	144	Natural variant	ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947
PRICKLE1	Q96MT3	128	196	144	144	Natural variant	ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947
PRICKLE1	Q96MT3	128	196	144	144	Natural variant	ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947
PRICKLE1	Q96MT3	128	196	144	144	Natural variant	ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947
PRKX	P51817	240	271	1	358	Chain	ID=PRO_0000086582;Note=cAMP-dependent protein kinase catalytic subunit PRKX
PRKX	P51817	200	239	1	358	Chain	ID=PRO_0000086582;Note=cAMP-dependent protein kinase catalytic subunit PRKX
PRKX	P51817	240	271	49	303	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKX	P51817	200	239	49	303	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PRKX	P51817	200	239	203	203	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q922R0
PRKX	P51817	200	239	202	202	Mutagenesis	Note=Constitutive kinase activity%3B when associated with Q-93. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16236808;Dbxref=PMID:16236808
RIMBP2	O15034	734	787	1	1052	Chain	ID=PRO_0000221383;Note=RIMS-binding protein 2
RIMBP2	O15034	734	787	1	863	Alternative sequence	ID=VSP_009213;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
RIMBP2	O15034	734	787	735	737	Alternative sequence	ID=VSP_009214;Note=In isoform 2. PHC->MVS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RIMBP2	O15034	734	787	738	1052	Alternative sequence	ID=VSP_009215;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRR5L	Q6MZQ0	55	81	1	368	Chain	ID=PRO_0000332709;Note=Proline-rich protein 5-like
PRR5L	Q6MZQ0	148	195	1	368	Chain	ID=PRO_0000332709;Note=Proline-rich protein 5-like
PRR5L	Q6MZQ0	55	81	1	368	Chain	ID=PRO_0000332709;Note=Proline-rich protein 5-like
PRR5L	Q6MZQ0	148	195	1	368	Chain	ID=PRO_0000332709;Note=Proline-rich protein 5-like
PRR5L	Q6MZQ0	55	81	1	229	Alternative sequence	ID=VSP_033375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRR5L	Q6MZQ0	148	195	1	229	Alternative sequence	ID=VSP_033375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRR5L	Q6MZQ0	55	81	1	229	Alternative sequence	ID=VSP_033375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRR5L	Q6MZQ0	148	195	1	229	Alternative sequence	ID=VSP_033375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRR5L	Q6MZQ0	55	81	1	81	Alternative sequence	ID=VSP_033376;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRR5L	Q6MZQ0	55	81	1	81	Alternative sequence	ID=VSP_033376;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRR5L	Q6MZQ0	148	195	149	195	Alternative sequence	ID=VSP_033378;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRR5L	Q6MZQ0	148	195	149	195	Alternative sequence	ID=VSP_033378;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PSMC3	P17980	197	245	1	439	Chain	ID=PRO_0000084698;Note=26S proteasome regulatory subunit 6A
PSMC3	P17980	151	197	1	439	Chain	ID=PRO_0000084698;Note=26S proteasome regulatory subunit 6A
PSMC3	P17980	130	151	1	439	Chain	ID=PRO_0000084698;Note=26S proteasome regulatory subunit 6A
PSMC3	P17980	53	95	1	439	Chain	ID=PRO_0000084698;Note=26S proteasome regulatory subunit 6A
PSMC3	P17980	25	53	1	439	Chain	ID=PRO_0000084698;Note=26S proteasome regulatory subunit 6A
PSMC3	P17980	197	245	227	234	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
PPP1R17	O96001	27	78	1	155	Chain	ID=PRO_0000083869;Note=Protein phosphatase 1 regulatory subunit 17
PPP1R17	O96001	78	129	1	155	Chain	ID=PRO_0000083869;Note=Protein phosphatase 1 regulatory subunit 17
PPP1R17	O96001	27	78	68	68	Modified residue	Note=Phosphothreonine%3B by PKG/PRKG1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10051666;Dbxref=PMID:10051666
PPP1R17	O96001	78	129	119	119	Modified residue	Note=Phosphothreonine%3B by PKG/PRKG1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10051666;Dbxref=PMID:10051666
PPP1R17	O96001	27	78	28	78	Alternative sequence	ID=VSP_042736;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP1R17	O96001	78	129	28	78	Alternative sequence	ID=VSP_042736;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPOX	P50336	329	366	1	477	Chain	ID=PRO_0000135270;Note=Protoporphyrinogen oxidase
PPOX	P50336	329	366	1	477	Chain	ID=PRO_0000135270;Note=Protoporphyrinogen oxidase
PPOX	P50336	329	366	330	330	Natural variant	ID=VAR_070413;Note=In VP%3B strongly decreases enzyme activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12859407,ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:12859407,PMID:21048046,PMID:23467411
PPOX	P50336	329	366	330	330	Natural variant	ID=VAR_070413;Note=In VP%3B strongly decreases enzyme activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12859407,ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:12859407,PMID:21048046,PMID:23467411
PPOX	P50336	329	366	332	332	Natural variant	ID=VAR_070414;Note=In VP%3B abolishes activity%3B impairs protein folding and/or stability. G->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18570668,ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23430901;Dbxref=PMID:18570668,PMID:21048046,PMID:23430901
PPOX	P50336	329	366	332	332	Natural variant	ID=VAR_070414;Note=In VP%3B abolishes activity%3B impairs protein folding and/or stability. G->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18570668,ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23430901;Dbxref=PMID:18570668,PMID:21048046,PMID:23430901
PPOX	P50336	329	366	335	335	Natural variant	ID=VAR_070415;Note=In VP%3B strongly decreases enzyme activity%3B impairs protein folding and/or stability. V->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10486317,ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:10486317,PMID:21048046,PMID:23467411
PPOX	P50336	329	366	335	335	Natural variant	ID=VAR_070415;Note=In VP%3B strongly decreases enzyme activity%3B impairs protein folding and/or stability. V->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10486317,ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:10486317,PMID:21048046,PMID:23467411
PPOX	P50336	329	366	348	348	Natural variant	ID=VAR_070416;Note=In VP%3B results in enzyme activity decrease%3B impairs protein folding and/or stability%3B more resistant to thermal denaturation than wild-type enzyme. Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10870850,ECO:0000269|PubMed:12922165,ECO:0000269|PubMed:21048046;Dbxref=dbSNP:rs900431442,PMID:10870850,PMID:12922165,PMID:21048046
PPOX	P50336	329	366	348	348	Natural variant	ID=VAR_070416;Note=In VP%3B results in enzyme activity decrease%3B impairs protein folding and/or stability%3B more resistant to thermal denaturation than wild-type enzyme. Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10870850,ECO:0000269|PubMed:12922165,ECO:0000269|PubMed:21048046;Dbxref=dbSNP:rs900431442,PMID:10870850,PMID:12922165,PMID:21048046
PPOX	P50336	329	366	349	349	Natural variant	ID=VAR_070417;Note=In VP%3B decreases enzyme activity. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411,ECO:0000269|PubMed:9811936;Dbxref=dbSNP:rs28936676,PMID:21048046,PMID:23467411,PMID:9811936
PPOX	P50336	329	366	349	349	Natural variant	ID=VAR_070417;Note=In VP%3B decreases enzyme activity. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411,ECO:0000269|PubMed:9811936;Dbxref=dbSNP:rs28936676,PMID:21048046,PMID:23467411,PMID:9811936
PPOX	P50336	329	366	350	350	Natural variant	ID=VAR_070418;Note=In VP%3B abolishes activity%3B impairs protein folding and/or stability. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10486317,ECO:0000269|PubMed:21048046;Dbxref=PMID:10486317,PMID:21048046
PPOX	P50336	329	366	350	350	Natural variant	ID=VAR_070418;Note=In VP%3B abolishes activity%3B impairs protein folding and/or stability. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10486317,ECO:0000269|PubMed:21048046;Dbxref=PMID:10486317,PMID:21048046
PPOX	P50336	329	366	358	358	Natural variant	ID=VAR_070419;Note=In VP%3B strongly decreases enzyme activity%3B impairs protein folding and/or stability. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:9811936;Dbxref=dbSNP:rs374936130,PMID:21048046,PMID:9811936
PPOX	P50336	329	366	358	358	Natural variant	ID=VAR_070419;Note=In VP%3B strongly decreases enzyme activity%3B impairs protein folding and/or stability. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:9811936;Dbxref=dbSNP:rs374936130,PMID:21048046,PMID:9811936
PPOX	P50336	329	366	331	331	Mutagenesis	Note=Decreases enzyme activity by 50%25. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:21048046,PMID:23467411
PPOX	P50336	329	366	331	331	Mutagenesis	Note=Decreases enzyme activity by 50%25. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:21048046,PMID:23467411
PPOX	P50336	329	366	334	334	Mutagenesis	Note=Decreases enzyme activity by 86%25. L->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:21048046,PMID:23467411
PPOX	P50336	329	366	334	334	Mutagenesis	Note=Decreases enzyme activity by 86%25. L->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:21048046,PMID:23467411
PPOX	P50336	329	366	347	347	Mutagenesis	Note=Decreases enzyme activity by 45%25. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:21048046,PMID:23467411
PPOX	P50336	329	366	347	347	Mutagenesis	Note=Decreases enzyme activity by 45%25. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21048046,ECO:0000269|PubMed:23467411;Dbxref=PMID:21048046,PMID:23467411
PPOX	P50336	329	366	330	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	330	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	337	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	337	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	341	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	341	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	349	352	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	349	352	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	354	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	354	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	358	361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	358	361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	363	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
PPOX	P50336	329	366	363	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKS
POU6F2	P78424	295	342	1	691	Chain	ID=PRO_0000100762;Note=POU domain%2C class 6%2C transcription factor 2
POU6F2	P78424	295	342	167	446	Compositional bias	Note=Gln-rich
PODXL	O00592	235	267	23	558	Chain	ID=PRO_0000024754;Note=Podocalyxin
PODXL	O00592	235	267	23	461	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PODXL	O00592	235	267	35	334	Compositional bias	Note=Thr-rich
PODXL	O00592	235	267	236	268	Alternative sequence	ID=VSP_037220;Note=In isoform 2. LETVFHHVSQAGLELLTSGDLPTLASQSAGITA->P;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9188463,ECO:0000303|Ref.2;Dbxref=PMID:15489334,PMID:9188463
REN	P00797	320	353	67	406	Chain	ID=PRO_0000026082;Note=Renin
REN	P00797	320	353	86	403	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
REN	P00797	320	353	325	362	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20927107;Dbxref=PMID:20927107
REN	P00797	320	353	351	351	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
REN	P00797	320	353	318	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G27
REN	P00797	320	353	321	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1W
REN	P00797	320	353	325	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1W
REN	P00797	320	353	334	338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1W
REN	P00797	320	353	341	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1W
REN	P00797	320	353	347	350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1W
UPF1	Q92900	619	667	1	1129	Chain	ID=PRO_0000080716;Note=Regulator of nonsense transcripts 1
UPF1	Q92900	619	667	647	648	Mutagenesis	Note=Loss of ATPase activity and helicase activity. DE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10999600,ECO:0000269|PubMed:17159905;Dbxref=PMID:10999600,PMID:17159905
UPF1	Q92900	619	667	647	648	Mutagenesis	Note=Loss of ATPase activity and helicase activity. Inhibits ZC3H12A-mediated IL6 mRNA degradation. DE->AA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10999600,ECO:0000269|PubMed:17159905,ECO:0000269|PubMed:26000482;Dbxref=PMID:10999600,PMID:17159905,PMID:26000482
UPF1	Q92900	619	667	600	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	622	627	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	630	632	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	634	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	642	646	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	649	651	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	654	661	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	662	664	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	665	672	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
PON1	P27169	260	303	2	355	Chain	ID=PRO_0000223281;Note=Serum paraoxonase/arylesterase 1
PON1	P27169	260	303	269	269	Metal binding	Note=Calcium 1%3B catalytic
PON1	P27169	260	303	270	270	Metal binding	Note=Calcium 1%3B catalytic
PON1	P27169	260	303	270	270	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PON1	P27169	260	303	42	353	Disulfide bond	Note=In form B;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15098021,ECO:0000269|PubMed:8292612;Dbxref=PMID:15098021,PMID:8292612
PON1	P27169	260	303	284	284	Mutagenesis	Note=No loss of activity. C->A%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7638166;Dbxref=PMID:7638166
PON1	P27169	260	303	256	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V04
PON1	P27169	260	303	265	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V04
PON1	P27169	260	303	275	277	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V04
PON1	P27169	260	303	280	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V04
PON1	P27169	260	303	288	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V04
PON1	P27169	260	303	302	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V04
PROCA1	Q8NCQ7	4	32	1	364	Chain	ID=PRO_0000336063;Note=Protein PROCA1
PROCA1	Q8NCQ7	4	32	1	30	Alternative sequence	ID=VSP_053931;Note=In isoform 3. MWVRTTLTIERWTKEKTEPKARSWDEALSD->MSITY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PROCA1	Q8NCQ7	4	32	27	58	Alternative sequence	ID=VSP_033988;Note=In isoform 2. ALSDVNRLPSWERGHLLAGVASSTDVSTFSEG->SRCR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRDX6	P30041	84	133	2	224	Chain	ID=PRO_0000135102;Note=Peroxiredoxin-6
PRDX6	P30041	84	133	5	169	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PRDX6	P30041	84	133	89	89	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PRDX6	P30041	84	133	76	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PRX
PRDX6	P30041	84	133	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PRX
PRDX6	P30041	84	133	109	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PRX
PRDX6	P30041	84	133	117	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B6M
PRDX6	P30041	84	133	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PRX
PRDX6	P30041	84	133	128	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B6M
PRDX6	P30041	84	133	133	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PRX
PROSER1	Q86XN7	214	243	1	944	Chain	ID=PRO_0000274309;Note=Proline and serine-rich protein 1
PROSER1	Q86XN7	214	243	185	386	Compositional bias	Note=Pro-rich
POP1	Q99575	570	634	1	1024	Chain	ID=PRO_0000058513;Note=Ribonucleases P/MRP protein subunit POP1
POP1	Q99575	570	634	1	1024	Chain	ID=PRO_0000058513;Note=Ribonucleases P/MRP protein subunit POP1
POP1	Q99575	570	634	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
POP1	Q99575	570	634	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
POP1	Q99575	570	634	582	582	Natural variant	ID=VAR_078771;Note=In ANXD2. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27380734,ECO:0000269|PubMed:28067412;Dbxref=dbSNP:rs1060505023,PMID:27380734,PMID:28067412
POP1	Q99575	570	634	582	582	Natural variant	ID=VAR_078771;Note=In ANXD2. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27380734,ECO:0000269|PubMed:28067412;Dbxref=dbSNP:rs1060505023,PMID:27380734,PMID:28067412
POP1	Q99575	570	634	583	583	Natural variant	ID=VAR_067755;Note=In ANXD2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21455487;Dbxref=dbSNP:rs374828868,PMID:21455487
POP1	Q99575	570	634	583	583	Natural variant	ID=VAR_067755;Note=In ANXD2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21455487;Dbxref=dbSNP:rs374828868,PMID:21455487
PPP1R14A	Q96A00	94	105	1	147	Chain	ID=PRO_0000071486;Note=Protein phosphatase 1 regulatory subunit 14A
PPP1R14A	Q96A00	67	94	1	147	Chain	ID=PRO_0000071486;Note=Protein phosphatase 1 regulatory subunit 14A
PPP1R14A	Q96A00	94	105	35	120	Region	Note=Inhibitory
PPP1R14A	Q96A00	67	94	35	120	Region	Note=Inhibitory
PPP1R14A	Q96A00	94	105	68	94	Alternative sequence	ID=VSP_011841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11467857;Dbxref=PMID:11467857
PPP1R14A	Q96A00	67	94	68	94	Alternative sequence	ID=VSP_011841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11467857;Dbxref=PMID:11467857
PPP1R14B	Q96C90	114	125	2	147	Chain	ID=PRO_0000071490;Note=Protein phosphatase 1 regulatory subunit 14B
RERG	Q96A58	20	39	1	199	Chain	ID=PRO_0000082723;Note=Ras-related and estrogen-regulated growth inhibitor
RERG	Q96A58	20	39	1	199	Chain	ID=PRO_0000082723;Note=Ras-related and estrogen-regulated growth inhibitor
RERG	Q96A58	20	39	1	199	Chain	ID=PRO_0000082723;Note=Ras-related and estrogen-regulated growth inhibitor
RERG	Q96A58	20	39	13	20	Nucleotide binding	Note=GTP
RERG	Q96A58	20	39	13	20	Nucleotide binding	Note=GTP
RERG	Q96A58	20	39	13	20	Nucleotide binding	Note=GTP
RERG	Q96A58	20	39	21	39	Alternative sequence	ID=VSP_043393;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RERG	Q96A58	20	39	21	39	Alternative sequence	ID=VSP_043393;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RERG	Q96A58	20	39	21	39	Alternative sequence	ID=VSP_043393;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RERG	Q96A58	20	39	19	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATV
RERG	Q96A58	20	39	19	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATV
RERG	Q96A58	20	39	19	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATV
REST	Q13127	299	327	1	1097	Chain	ID=PRO_0000269547;Note=RE1-silencing transcription factor
REST	Q13127	299	327	304	326	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
REST	Q13127	299	327	145	418	Region	Note=Interaction with ZFP90;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21284946;Dbxref=PMID:21284946
REST	Q13127	299	327	301	313	Alternative sequence	ID=VSP_022064;Note=In isoform 2. ERPYKCELCPYSS->KRSFLVHKFSSLF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7871435;Dbxref=PMID:7871435
REST	Q13127	299	327	304	326	Alternative sequence	ID=VSP_022067;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
REST	Q13127	299	327	314	1097	Alternative sequence	ID=VSP_022065;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7871435;Dbxref=PMID:7871435
REST	Q13127	299	327	322	322	Natural variant	ID=VAR_076335;Note=In WT6%3B inhibits transcriptional repression activity. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26551668;Dbxref=dbSNP:rs869025312,PMID:26551668
PPP1CA	P62136	139	174	2	330	Chain	ID=PRO_0000058774;Note=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
PPP1CA	P62136	62	139	2	330	Chain	ID=PRO_0000058774;Note=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
PPP1CA	P62136	18	62	2	330	Chain	ID=PRO_0000058774;Note=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
PPP1CA	P62136	62	139	125	125	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	64	64	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	66	66	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	92	92	Metal binding	Note=Manganese
PPP1CA	P62136	62	139	92	92	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	92	92	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	124	124	Metal binding	Note=Manganese
PPP1CA	P62136	62	139	124	124	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	139	174	173	173	Metal binding	Note=Manganese
PPP1CA	P62136	139	174	173	173	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	18	62	22	22	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPP1CA	P62136	18	62	18	18	Alternative sequence	ID=VSP_043377;Note=In isoform 2. E->EGSRVLTPHCAP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8384581;Dbxref=PMID:8384581
PPP1CA	P62136	62	139	19	62	Alternative sequence	ID=VSP_046754;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1CA	P62136	18	62	19	62	Alternative sequence	ID=VSP_046754;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1CA	P62136	18	62	9	18	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	19	21	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	32	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	51	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	69	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	100	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	115	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	124	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ALZ
PPP1CA	P62136	62	139	128	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	136	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	136	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	146	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	166	168	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
RBP4	P02753	118	189	19	201	Chain	ID=PRO_0000017961;Note=Retinol-binding protein 4
RBP4	P02753	118	189	19	201	Chain	ID=PRO_0000017961;Note=Retinol-binding protein 4
RBP4	P02753	118	189	19	200	Chain	ID=PRO_0000017962;Note=Plasma retinol-binding protein(1-182)
RBP4	P02753	118	189	19	200	Chain	ID=PRO_0000017962;Note=Plasma retinol-binding protein(1-182)
RBP4	P02753	118	189	19	199	Chain	ID=PRO_0000017963;Note=Plasma retinol-binding protein(1-181)
RBP4	P02753	118	189	19	199	Chain	ID=PRO_0000017963;Note=Plasma retinol-binding protein(1-181)
RBP4	P02753	118	189	19	197	Chain	ID=PRO_0000017964;Note=Plasma retinol-binding protein(1-179)
RBP4	P02753	118	189	19	197	Chain	ID=PRO_0000017964;Note=Plasma retinol-binding protein(1-179)
RBP4	P02753	118	189	19	194	Chain	ID=PRO_0000017965;Note=Plasma retinol-binding protein(1-176)
RBP4	P02753	118	189	19	194	Chain	ID=PRO_0000017965;Note=Plasma retinol-binding protein(1-176)
RBP4	P02753	118	189	139	139	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00724
RBP4	P02753	118	189	139	139	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00724
RBP4	P02753	118	189	22	178	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2444024;Dbxref=PMID:2444024
RBP4	P02753	118	189	22	178	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2444024;Dbxref=PMID:2444024
RBP4	P02753	118	189	88	192	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2444024;Dbxref=PMID:2444024
RBP4	P02753	118	189	88	192	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2444024;Dbxref=PMID:2444024
RBP4	P02753	118	189	138	147	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2444024;Dbxref=PMID:2444024
RBP4	P02753	118	189	138	147	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2444024;Dbxref=PMID:2444024
RBP4	P02753	118	189	118	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	118	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	129	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	129	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	145	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	145	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	164	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	164	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NU2
RBP4	P02753	118	189	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BRP
RBP4	P02753	118	189	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BRP
RETN	Q9HD89	39	65	19	108	Chain	ID=PRO_0000030341;Note=Resistin
RETN	Q9HD89	39	65	51	104	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99P87
RETN	Q9HD89	39	65	63	103	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99P87
RETN	Q9HD89	39	65	40	66	Alternative sequence	ID=VSP_055861;Note=In isoform 2. IFRAISSIGLECQSVTSRGDLATCPRG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15248836;Dbxref=PMID:15248836
REXO1	Q8N1G1	637	672	1	1221	Chain	ID=PRO_0000239232;Note=RNA exonuclease 1 homolog
MTRF1	O75570	375	408	407	407	Natural variant	ID=VAR_051789;Note=I->V;Dbxref=dbSNP:rs9315812
MTRF1	O75570	375	408	407	407	Natural variant	ID=VAR_051789;Note=I->V;Dbxref=dbSNP:rs9315812
PPP3CA	Q08209	446	456	2	521	Chain	ID=PRO_0000058822;Note=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
PPP3CA	Q08209	318	360	2	521	Chain	ID=PRO_0000058822;Note=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
PPP3CA	Q08209	19	86	2	521	Chain	ID=PRO_0000058822;Note=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
PPP3CA	Q08209	318	360	56	340	Region	Note=Catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP3CA	Q08209	19	86	56	340	Region	Note=Catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP3CA	Q08209	318	360	327	336	Region	Note=Interaction with PxIxIF motif in substrate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17498738,ECO:0000269|PubMed:17502104,ECO:0000269|PubMed:22343722,ECO:0000269|PubMed:23468591,ECO:0000269|PubMed:26248042;Dbxref=PMID:17498738,PMID:17502104,PMID:22343722,PMID:23468591,PMID:26248042
PPP3CA	Q08209	318	360	341	369	Region	Note=Calcineurin B binding;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12218175,ECO:0000269|PubMed:12357034,ECO:0000269|PubMed:17498738,ECO:0000269|PubMed:23468591,ECO:0000269|PubMed:27974827,ECO:0000269|PubMed:8524402;Dbxref=PMID:12218175,PMID:12357034,PMID:17498738,PMID:23468591,PMID:27974827,PMID:8524402
PPP3CA	Q08209	318	360	352	352	Site	Note=Interaction with PxVP motif in substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23468591,ECO:0000269|PubMed:27974827;Dbxref=PMID:23468591,PMID:27974827
PPP3CA	Q08209	19	86	20	86	Alternative sequence	ID=VSP_054467;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21647268;Dbxref=PMID:21647268
PPP3CA	Q08209	318	360	87	318	Alternative sequence	ID=VSP_047755;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20590401;Dbxref=PMID:20590401
PPP3CA	Q08209	318	360	318	359	Alternative sequence	ID=VSP_043378;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20590401;Dbxref=PMID:20590401
PPP3CA	Q08209	446	456	448	457	Alternative sequence	ID=VSP_018562;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:20590401;Dbxref=PMID:14702039,PMID:15489334,PMID:20590401
PPP3CA	Q08209	446	456	445	521	Natural variant	ID=VAR_080351;Note=In IECEE1%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28942967;Dbxref=PMID:28942967
PPP3CA	Q08209	446	456	447	447	Natural variant	ID=VAR_080352;Note=In IECEE1%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28942967;Dbxref=PMID:28942967
PPP3CA	Q08209	318	360	328	332	Mutagenesis	Note=Loss of Ca(2+)-mediated transcription factor NFAT activation%3B when associated with F-341. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26248042;Dbxref=PMID:26248042
PPP3CA	Q08209	318	360	341	341	Mutagenesis	Note=Resistant to cyclosporin A-mediated inhibition. Loss of Ca(2+)-mediated transcription factor NFAT activation%3B when associated with N-288%2C A-228 or 328-V--R-332 DEL. Partial loss in Ca(2+)-mediated transcription factor NFAT activation%3B when associated with F-288. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26248042;Dbxref=PMID:26248042
PPP3CA	Q08209	19	86	31	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	19	86	43	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	19	86	58	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	19	86	77	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	19	86	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	318	360	319	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	318	360	328	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	318	360	344	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CA	Q08209	318	360	349	369	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F0Z
PPP3CC	P48454	314	356	1	512	Chain	ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
PPP3CC	P48454	356	380	1	512	Chain	ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
PPP3CC	P48454	440	450	1	512	Chain	ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
PPP3CC	P48454	314	356	52	343	Region	Note=Catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP3CC	P48454	314	356	344	366	Region	Note=Calcineurin B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16298
PPP3CC	P48454	356	380	344	366	Region	Note=Calcineurin B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16298
PPP3CC	P48454	356	380	380	380	Alternative sequence	ID=VSP_045211;Note=In isoform 3. E->EDHYIPSYQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP3CC	P48454	440	450	442	451	Alternative sequence	ID=VSP_037946;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1339277,ECO:0000303|Ref.2;Dbxref=PMID:1339277
PPP4C	P60510	67	101	2	307	Chain	ID=PRO_0000058883;Note=Serine/threonine-protein phosphatase 4 catalytic subunit
PPP4C	P60510	101	159	2	307	Chain	ID=PRO_0000058883;Note=Serine/threonine-protein phosphatase 4 catalytic subunit
PPP4C	P60510	67	101	2	307	Chain	ID=PRO_0000058883;Note=Serine/threonine-protein phosphatase 4 catalytic subunit
PPP4C	P60510	101	159	2	307	Chain	ID=PRO_0000058883;Note=Serine/threonine-protein phosphatase 4 catalytic subunit
PPP4C	P60510	101	159	115	115	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P36873
PPP4C	P60510	101	159	115	115	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P36873
PPP4C	P60510	67	101	82	82	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67775
PPP4C	P60510	67	101	82	82	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67775
PPP4C	P60510	67	101	82	82	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67775
PPP4C	P60510	67	101	82	82	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67775
PPP4C	P60510	101	159	114	114	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67775
PPP4C	P60510	101	159	114	114	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67775
PPP4C	P60510	67	101	76	76	Mutagenesis	Note=Diminishes interaction with PPP4R4. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18715871;Dbxref=PMID:18715871
PPP4C	P60510	67	101	76	76	Mutagenesis	Note=Diminishes interaction with PPP4R4. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18715871;Dbxref=PMID:18715871
PPP4C	P60510	67	101	82	82	Mutagenesis	Note=Loss of activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20154705;Dbxref=PMID:20154705
PPP4C	P60510	67	101	82	82	Mutagenesis	Note=Loss of activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20154705;Dbxref=PMID:20154705
PPP4C	P60510	101	159	107	107	Mutagenesis	Note=Diminishes interaction with PPP4R4. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18715871;Dbxref=PMID:18715871
PPP4C	P60510	101	159	107	107	Mutagenesis	Note=Diminishes interaction with PPP4R4. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18715871;Dbxref=PMID:18715871
PPP4R2	Q9NY27	39	95	1	417	Chain	ID=PRO_0000299365;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 2
PPP4R2	Q9NY27	140	164	1	417	Chain	ID=PRO_0000299365;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 2
PPP4R2	Q9NY27	165	212	1	417	Chain	ID=PRO_0000299365;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 2
PPP4R2	Q9NY27	140	164	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PPP4R2	Q9NY27	39	95	1	56	Alternative sequence	ID=VSP_027612;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP4R2	Q9NY27	39	95	39	96	Alternative sequence	ID=VSP_027613;Note=In isoform 2. MIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNG->I;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP4R2	Q9NY27	165	212	174	174	Natural variant	ID=VAR_051749;Note=P->L;Dbxref=dbSNP:rs2306983
PPP6R2	O75170	534	561	1	966	Chain	ID=PRO_0000046098;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 2
PPP6R2	O75170	867	950	1	966	Chain	ID=PRO_0000046098;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 2
PPP6R2	O75170	534	561	535	561	Alternative sequence	ID=VSP_030758;Note=In isoform 2%2C isoform 3%2C isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9734811;Dbxref=PMID:15489334,PMID:9734811
ACP2	P11117	183	213	31	423	Chain	ID=PRO_0000023960;Note=Lysosomal acid phosphatase
ACP2	P11117	150	183	31	423	Chain	ID=PRO_0000023960;Note=Lysosomal acid phosphatase
ACP2	P11117	70	99	31	423	Chain	ID=PRO_0000023960;Note=Lysosomal acid phosphatase
ACP2	P11117	183	213	31	380	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACP2	P11117	150	183	31	380	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACP2	P11117	70	99	31	380	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACP2	P11117	70	99	92	92	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ACP2	P11117	150	183	167	167	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ACP2	P11117	150	183	177	177	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ACP2	P11117	183	213	191	191	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3056714;Dbxref=PMID:3056714
ACP2	P11117	183	213	159	370	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ACP2	P11117	150	183	159	370	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ACP2	P11117	183	213	212	310	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ACP2	P11117	150	183	151	160	Alternative sequence	ID=VSP_045629;Note=In isoform 2. LLKFPLGPCP->VRVASPSLGW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACP2	P11117	183	213	161	423	Alternative sequence	ID=VSP_045630;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACP2	P11117	150	183	161	423	Alternative sequence	ID=VSP_045630;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PREP	P48147	274	338	1	710	Chain	ID=PRO_0000122401;Note=Prolyl endopeptidase
PREP	P48147	274	338	298	298	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PREP	P48147	274	338	319	319	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
PREP	P48147	274	338	280	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	285	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	290	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	299	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	312	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	323	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	327	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
PREP	P48147	274	338	337	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DDU
RPA3	P35244	33	58	2	121	Chain	ID=PRO_0000097276;Note=Replication protein A 14 kDa subunit
RPA3	P35244	33	58	2	121	Chain	ID=PRO_0000097276;Note=Replication protein A 14 kDa subunit
RPA3	P35244	33	58	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068
RPA3	P35244	33	58	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068
RPA3	P35244	33	58	24	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA3	P35244	33	58	24	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA3	P35244	33	58	38	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA3	P35244	33	58	38	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA3	P35244	33	58	50	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA3	P35244	33	58	50	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
PNKD	Q8N490	175	205	1	385	Chain	ID=PRO_0000299549;Note=Probable hydrolase PNKD
PNKD	Q8N490	260	289	1	385	Chain	ID=PRO_0000299549;Note=Probable hydrolase PNKD
PNKD	Q8N490	175	205	176	176	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKD	Q8N490	175	205	177	177	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKD	Q8N490	175	205	143	385	Alternative sequence	ID=VSP_027740;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15188056,ECO:0000303|PubMed:15188498,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:15188056,PMID:15188498,PMID:15489334,PMID:17974005
PNKD	Q8N490	260	289	143	385	Alternative sequence	ID=VSP_027740;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15188056,ECO:0000303|PubMed:15188498,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:15188056,PMID:15188498,PMID:15489334,PMID:17974005
PNLDC1	Q8NA58	202	250	1	520	Chain	ID=PRO_0000311365;Note=Poly(A)-specific ribonuclease PNLDC1
POLH	Q9Y253	255	294	1	713	Chain	ID=PRO_0000173986;Note=DNA polymerase eta
POLH	Q9Y253	336	358	1	713	Chain	ID=PRO_0000173986;Note=DNA polymerase eta
POLH	Q9Y253	255	294	9	259	Domain	Note=UmuC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
POLH	Q9Y253	255	294	263	263	Natural variant	ID=VAR_021230;Note=In XPV%3B impairs translesion synthesis. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11773631;Dbxref=PMID:11773631
POLH	Q9Y253	255	294	266	266	Natural variant	ID=VAR_070837;Note=In XPV. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24130121;Dbxref=PMID:24130121
POLH	Q9Y253	255	294	256	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RNO
POLH	Q9Y253	255	294	261	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KFZ
POLH	Q9Y253	255	294	275	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KFZ
POLH	Q9Y253	255	294	283	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KFZ
POLH	Q9Y253	255	294	292	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KFZ
POLH	Q9Y253	336	358	334	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KFZ
TMEM123	Q8N131	33	52	27	208	Chain	ID=PRO_0000045058;Note=Porimin
TMEM123	Q8N131	33	52	27	166	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM123	Q8N131	33	52	52	153	Compositional bias	Note=Thr-rich
TMEM123	Q8N131	33	52	46	46	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM123	Q8N131	33	52	50	50	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM123	Q8N131	33	52	34	52	Alternative sequence	ID=VSP_016605;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11481458;Dbxref=PMID:11481458
PORCN	Q9H237	391	428	1	461	Chain	ID=PRO_0000213137;Note=Protein-serine O-palmitoleoyltransferase porcupine
PORCN	Q9H237	391	428	359	396	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PORCN	Q9H237	391	428	397	417	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PORCN	Q9H237	391	428	418	461	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
POT1	Q9NUX5	316	335	1	634	Chain	ID=PRO_0000121728;Note=Protection of telomeres protein 1
POT1	Q9NUX5	182	234	1	634	Chain	ID=PRO_0000121728;Note=Protection of telomeres protein 1
POT1	Q9NUX5	85	182	1	634	Chain	ID=PRO_0000121728;Note=Protection of telomeres protein 1
POT1	Q9NUX5	85	182	89	89	Natural variant	ID=VAR_071390;Note=In CMM10%3B complete abolition of POT1-DNA complex formation%2C thus disrupting the interaction with telomeres and leading to elongated telomeres. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24686849;Dbxref=dbSNP:rs587777472,PMID:24686849
POT1	Q9NUX5	85	182	94	94	Natural variant	ID=VAR_071391;Note=In CMM10%3B complete abolition of POT1-DNA complex formation%2C thus disrupting the interaction with telomeres and leading to elongated telomeres. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24686849;Dbxref=dbSNP:rs587777474,PMID:24686849
POT1	Q9NUX5	85	182	95	95	Natural variant	ID=VAR_075717;Note=In GLM9. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25482530;Dbxref=dbSNP:rs797045168,PMID:25482530
POT1	Q9NUX5	85	182	137	137	Natural variant	ID=VAR_071392;Note=In CMM10%3B increased telomere intensity signals and telomere fragility. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24686846;Dbxref=dbSNP:rs587777475,PMID:24686846
POT1	Q9NUX5	182	234	224	224	Natural variant	ID=VAR_071393;Note=In CMM10. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24686846;Dbxref=dbSNP:rs202187871,PMID:24686846
POT1	Q9NUX5	85	182	78	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	85	182	92	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	85	182	127	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	85	182	153	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	85	182	161	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	182	234	175	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	85	182	175	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	182	234	200	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KJP
POT1	Q9NUX5	182	234	207	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	182	234	214	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	182	234	217	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	182	234	226	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XJV
POT1	Q9NUX5	316	335	334	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UN7
RER1	O15258	27	62	2	196	Chain	ID=PRO_0000207589;Note=Protein RER1
RER1	O15258	27	62	2	196	Chain	ID=PRO_0000207589;Note=Protein RER1
RER1	O15258	27	62	41	61	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RER1	O15258	27	62	41	61	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PPEF1	O14829	355	417	1	653	Chain	ID=PRO_0000058899;Note=Serine/threonine-protein phosphatase with EF-hands 1
PPEF1	O14829	355	417	121	455	Region	Note=Catalytic
PPEF1	O14829	355	417	403	403	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPEF1	O14829	355	417	328	355	Alternative sequence	ID=VSP_005099;Note=In isoform 1B. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPEF1	O14829	355	417	356	417	Alternative sequence	ID=VSP_005102;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPEF1	O14829	355	417	356	376	Alternative sequence	ID=VSP_005100;Note=In isoform 2. IIDILWSDPRGKNGCFPNTCR->SGYYGKQRHQDIKRESDFTKK;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPEF1	O14829	355	417	377	653	Alternative sequence	ID=VSP_005101;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPEF1	O14829	355	417	367	367	Natural variant	ID=VAR_051736;Note=K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9215685;Dbxref=dbSNP:rs1065074,PMID:9215685
RBFOX1	Q9NWB1	90	138	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	138	156	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	156	187	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	225	252	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	90	138	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	138	156	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	156	187	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	225	252	1	397	Chain	ID=PRO_0000081480;Note=RNA binding protein fox-1 homolog 1
RBFOX1	Q9NWB1	90	138	117	193	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX1	Q9NWB1	138	156	117	193	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX1	Q9NWB1	156	187	117	193	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX1	Q9NWB1	90	138	117	193	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX1	Q9NWB1	138	156	117	193	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX1	Q9NWB1	156	187	117	193	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX1	Q9NWB1	90	138	118	118	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	90	138	118	118	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	90	138	126	126	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	90	138	126	126	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	90	138	127	127	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	90	138	127	127	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	138	156	151	151	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	138	156	151	151	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	138	156	156	156	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	156	187	156	156	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	138	156	156	156	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	156	187	156	156	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	156	187	160	160	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	156	187	160	160	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	156	187	184	184	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	156	187	184	184	Site	Note=Interaction with RNA
RBFOX1	Q9NWB1	225	252	226	253	Alternative sequence	ID=VSP_030875;Note=In isoform 3. GTVLLCQANQEGSSMYSAPSSLVYTSAM->V;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10814712,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:10814712,PMID:14702039
RBFOX1	Q9NWB1	225	252	226	253	Alternative sequence	ID=VSP_030875;Note=In isoform 3. GTVLLCQANQEGSSMYSAPSSLVYTSAM->V;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10814712,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:10814712,PMID:14702039
RBFOX1	Q9NWB1	90	138	120	120	Mutagenesis	Note=Reduces RNA-binding affinity 160-fold. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	120	120	Mutagenesis	Note=Reduces RNA-binding affinity 160-fold. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	126	126	Mutagenesis	Note=Reduces RNA-binding affinity 1500-fold. F->A%2CI%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	126	126	Mutagenesis	Note=Reduces RNA-binding affinity 1500-fold. F->A%2CI%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	126	126	Mutagenesis	Note=Reduces RNA-binding affinity 15-fold. F->H%2CW;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	126	126	Mutagenesis	Note=Reduces RNA-binding affinity 15-fold. F->H%2CW;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	126	126	Mutagenesis	Note=No effect on RNA-binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	126	126	Mutagenesis	Note=No effect on RNA-binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	156	187	158	158	Mutagenesis	Note=Reduces RNA-binding affinity 700-fold. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	156	187	158	158	Mutagenesis	Note=Reduces RNA-binding affinity 700-fold. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	156	187	160	160	Mutagenesis	Note=Reduces RNA-binding affinity 30'000-fold. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	156	187	160	160	Mutagenesis	Note=Reduces RNA-binding affinity 30'000-fold. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16362037;Dbxref=PMID:16362037
RBFOX1	Q9NWB1	90	138	92	92	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBFOX1	Q9NWB1	90	138	92	92	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBFOX1	Q9NWB1	90	138	110	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N82
RBFOX1	Q9NWB1	90	138	110	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N82
RBFOX1	Q9NWB1	90	138	117	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	90	138	117	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	90	138	130	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	138	156	130	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	90	138	130	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	138	156	130	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	138	156	143	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	138	156	143	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	138	156	154	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	156	187	154	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	138	156	154	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	156	187	154	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	156	187	166	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	156	187	166	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	156	187	187	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RBFOX1	Q9NWB1	156	187	187	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZKA
RFX5	P48382	78	117	2	616	Chain	ID=PRO_0000215292;Note=DNA-binding protein RFX5
RFX5	P48382	78	117	2	616	Chain	ID=PRO_0000215292;Note=DNA-binding protein RFX5
RFX5	P48382	78	117	2	616	Chain	ID=PRO_0000215292;Note=DNA-binding protein RFX5
RFX5	P48382	78	117	92	168	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX5	P48382	78	117	92	168	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX5	P48382	78	117	92	168	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX5	P48382	78	117	25	90	Region	Note=N-terminal domain
RFX5	P48382	78	117	25	90	Region	Note=N-terminal domain
RFX5	P48382	78	117	25	90	Region	Note=N-terminal domain
RFX5	P48382	78	117	78	117	Alternative sequence	ID=VSP_055864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFX5	P48382	78	117	78	117	Alternative sequence	ID=VSP_055864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFX5	P48382	78	117	78	117	Alternative sequence	ID=VSP_055864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFX5	P48382	78	117	74	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KW3
RFX5	P48382	78	117	74	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KW3
RFX5	P48382	78	117	74	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KW3
RFX5	P48382	78	117	82	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KW3
RFX5	P48382	78	117	82	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KW3
RFX5	P48382	78	117	82	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KW3
PPIG	Q13427	20	45	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	45	81	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	81	96	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	254	309	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	20	45	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	45	81	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	81	96	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	254	309	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
PPIG	Q13427	20	45	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIG	Q13427	45	81	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIG	Q13427	81	96	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIG	Q13427	20	45	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIG	Q13427	45	81	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIG	Q13427	81	96	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIG	Q13427	254	309	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PPIG	Q13427	254	309	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PPIG	Q13427	254	309	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PPIG	Q13427	20	45	19	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	20	45	19	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	20	45	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	20	45	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	20	45	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	20	45	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFJ
PPIG	Q13427	45	81	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFJ
PPIG	Q13427	45	81	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	81	96	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	45	81	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	81	96	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	81	96	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
PPIG	Q13427	81	96	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFI
RFX6	Q8HWS3	224	260	1	928	Chain	ID=PRO_0000313721;Note=DNA-binding protein RFX6
RGCC	Q9H4X1	114	135	1	137	Chain	ID=PRO_0000274701;Note=Regulator of cell cycle RGCC
RGL1	Q9NZL6	9	46	1	768	Chain	ID=PRO_0000068885;Note=Ral guanine nucleotide dissociation stimulator-like 1
RGL1	Q9NZL6	410	439	1	768	Chain	ID=PRO_0000068885;Note=Ral guanine nucleotide dissociation stimulator-like 1
RGL1	Q9NZL6	583	668	1	768	Chain	ID=PRO_0000068885;Note=Ral guanine nucleotide dissociation stimulator-like 1
RGL1	Q9NZL6	410	439	232	501	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RGL1	Q9NZL6	583	668	648	735	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
RGL1	Q9NZL6	583	668	541	613	Compositional bias	Note=Ser-rich
RGL1	Q9NZL6	9	46	1	9	Alternative sequence	ID=VSP_001824;Note=In isoform B. MKLLWQAKM->MEVKPVGEPTQEVSKFKLSTKVESTGHWLVEDHVRIWEVLKTEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10760592,ECO:0000303|PubMed:15489334;Dbxref=PMID:10760592,PMID:15489334
RGL1	Q9NZL6	9	46	15	15	Sequence conflict	Note=W->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R1A	Q13522	82	134	1	171	Chain	ID=PRO_0000071477;Note=Protein phosphatase 1 regulatory subunit 1A
PPP1R1A	Q13522	82	134	109	109	Natural variant	ID=VAR_053898;Note=E->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8611507,ECO:0000269|Ref.2,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1249958,PMID:15489334,PMID:8611507
PPP5C	P53041	211	233	2	499	Chain	ID=PRO_0000058894;Note=Serine/threonine-protein phosphatase 5
PPP5C	P53041	211	233	184	499	Region	Note=Catalytic
PPP5C	P53041	211	233	206	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZX2
PPP5C	P53041	211	233	225	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZX2
PPP6C	O00743	153	223	1	305	Chain	ID=PRO_0000424504;Note=Serine/threonine-protein phosphatase 6 catalytic subunit
PPP6C	O00743	57	79	1	305	Chain	ID=PRO_0000424504;Note=Serine/threonine-protein phosphatase 6 catalytic subunit
PPP6C	O00743	153	223	2	305	Chain	ID=PRO_0000058877;Note=Serine/threonine-protein phosphatase 6 catalytic subunit%2C N-terminally processed
PPP6C	O00743	57	79	2	305	Chain	ID=PRO_0000058877;Note=Serine/threonine-protein phosphatase 6 catalytic subunit%2C N-terminally processed
PPP6C	O00743	153	223	163	163	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP6C	O00743	57	79	58	79	Alternative sequence	ID=VSP_038376;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP6C	O00743	57	79	61	64	Sequence conflict	Note=LCEL->AG;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPRC1	Q5VV67	114	163	1	1664	Chain	ID=PRO_0000296666;Note=Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
PPRC1	Q5VV67	163	197	1	1664	Chain	ID=PRO_0000296666;Note=Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
PPRC1	Q5VV67	1165	1183	1	1664	Chain	ID=PRO_0000296666;Note=Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
PPRC1	Q5VV67	114	163	1	120	Alternative sequence	ID=VSP_027229;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPRC1	Q5VV67	114	163	121	147	Alternative sequence	ID=VSP_027230;Note=In isoform 2. DQNEVSLLTALTEILDNADSENLSPFD->MRHCWGPCRATWMPPLSPSLRILGALE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPRC1	Q5VV67	114	163	122	122	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBM10	P98175	67	144	1	930	Chain	ID=PRO_0000081767;Note=RNA-binding protein 10
RBM10	P98175	192	221	1	930	Chain	ID=PRO_0000081767;Note=RNA-binding protein 10
RBM10	P98175	241	300	1	930	Chain	ID=PRO_0000081767;Note=RNA-binding protein 10
RBM10	P98175	700	722	1	930	Chain	ID=PRO_0000081767;Note=RNA-binding protein 10
RBM10	P98175	67	144	129	209	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM10	P98175	192	221	129	209	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM10	P98175	241	300	300	384	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM10	P98175	192	221	212	242	Zinc finger	Note=RanBP2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00322
RBM10	P98175	241	300	212	242	Zinc finger	Note=RanBP2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00322
RBM10	P98175	67	144	80	87	Compositional bias	Note=Poly-Arg
RBM10	P98175	67	144	113	125	Compositional bias	Note=Poly-Glu
RBM10	P98175	67	144	89	89	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
RBM10	P98175	700	722	718	718	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569
RBM10	P98175	67	144	68	144	Alternative sequence	ID=VSP_036173;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RBM10	P98175	67	144	130	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI
RBM10	P98175	67	144	142	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI
RBM10	P98175	192	221	190	193	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI
RBM10	P98175	192	221	194	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI
RBM10	P98175	192	221	200	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI
RBM10	P98175	192	221	220	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MXV
EBAG9	O00559	54	107	1	213	Chain	ID=PRO_0000097195;Note=Receptor-binding cancer antigen expressed on SiSo cells
EBAG9	O00559	107	143	1	213	Chain	ID=PRO_0000097195;Note=Receptor-binding cancer antigen expressed on SiSo cells
EBAG9	O00559	54	107	1	213	Chain	ID=PRO_0000097195;Note=Receptor-binding cancer antigen expressed on SiSo cells
EBAG9	O00559	107	143	1	213	Chain	ID=PRO_0000097195;Note=Receptor-binding cancer antigen expressed on SiSo cells
EBAG9	O00559	54	107	28	213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EBAG9	O00559	107	143	28	213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EBAG9	O00559	54	107	28	213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EBAG9	O00559	107	143	28	213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EBAG9	O00559	54	107	94	94	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
EBAG9	O00559	54	107	94	94	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PMEPA1	Q969W9	88	106	1	287	Chain	ID=PRO_0000185442;Note=Protein TMEPAI
PMEPA1	Q969W9	88	106	64	287	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RCOR3	Q9P2K3	16	42	1	495	Chain	ID=PRO_0000226781;Note=REST corepressor 3
RCOR3	Q9P2K3	255	281	1	495	Chain	ID=PRO_0000226781;Note=REST corepressor 3
RCOR3	Q9P2K3	16	42	1	83	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
RCOR3	Q9P2K3	255	281	237	273	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RCOR3	Q9P2K3	16	42	20	20	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RCOR3	Q9P2K3	16	42	42	42	Natural variant	ID=VAR_025517;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856928,PMID:15489334
RCOR3	Q9P2K3	255	281	237	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CZZ
RCOR3	Q9P2K3	255	281	270	272	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CZZ
RCOR3	Q9P2K3	255	281	275	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CZZ
PPP4R1	Q8TF05	253	306	1	950	Chain	ID=PRO_0000071527;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 1
PPP4R1	Q8TF05	231	253	1	950	Chain	ID=PRO_0000071527;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 1
PPP4R1	Q8TF05	195	231	1	950	Chain	ID=PRO_0000071527;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 1
PPP4R1	Q8TF05	146	195	1	950	Chain	ID=PRO_0000071527;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 1
PPP4R1	Q8TF05	146	195	127	164	Repeat	Note=HEAT 5
PPP4R1	Q8TF05	195	231	168	206	Repeat	Note=HEAT 6
PPP4R1	Q8TF05	146	195	168	206	Repeat	Note=HEAT 6
PPP4R1	Q8TF05	231	253	208	246	Repeat	Note=HEAT 7
PPP4R1	Q8TF05	195	231	208	246	Repeat	Note=HEAT 7
PPP4R1	Q8TF05	253	306	248	285	Repeat	Note=HEAT 8
PPP4R1	Q8TF05	231	253	248	285	Repeat	Note=HEAT 8
PPP4R1	Q8TF05	253	306	287	324	Repeat	Note=HEAT 9
PPP4R4	Q6NUP7	284	325	1	873	Chain	ID=PRO_0000311850;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 4
PPP4R4	Q6NUP7	670	684	1	873	Chain	ID=PRO_0000311850;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 4
PPP4R4	Q6NUP7	732	761	1	873	Chain	ID=PRO_0000311850;Note=Serine/threonine-protein phosphatase 4 regulatory subunit 4
PPP4R4	Q6NUP7	284	325	252	290	Repeat	Note=HEAT 2
PPP4R4	Q6NUP7	284	325	121	873	Alternative sequence	ID=VSP_029617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP4R4	Q6NUP7	670	684	121	873	Alternative sequence	ID=VSP_029617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP4R4	Q6NUP7	732	761	121	873	Alternative sequence	ID=VSP_029617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPA1	P27694	458	517	1	616	Chain	ID=PRO_0000423231;Note=Replication protein A 70 kDa DNA-binding subunit
RPA1	P27694	517	553	1	616	Chain	ID=PRO_0000423231;Note=Replication protein A 70 kDa DNA-binding subunit
RPA1	P27694	458	517	2	616	Chain	ID=PRO_0000097260;Note=Replication protein A 70 kDa DNA-binding subunit%2C N-terminally processed
RPA1	P27694	517	553	2	616	Chain	ID=PRO_0000097260;Note=Replication protein A 70 kDa DNA-binding subunit%2C N-terminally processed
RPA1	P27694	458	517	481	503	Zinc finger	Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPA1	P27694	458	517	458	458	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068
RPA1	P27694	517	553	553	553	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068
RPA1	P27694	458	517	500	500	Mutagenesis	Note=Loss of function in DNA replication and mismatch repair without effect on DNA-binding activity%3B when associated with S-503. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9430682;Dbxref=PMID:9430682
RPA1	P27694	458	517	503	503	Mutagenesis	Note=Loss of function in DNA replication and mismatch repair without effect on DNA-binding activity%3B when associated with S-500. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9430682;Dbxref=PMID:9430682
RPA1	P27694	458	517	455	458	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	460	471	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	477	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	491	493	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	494	496	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	497	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	501	504	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	505	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	458	517	512	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	517	553	512	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	517	553	526	532	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	517	553	533	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RPA1	P27694	517	553	544	550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1O
RFFL	Q8WZ73	197	225	1	363	Chain	ID=PRO_0000056025;Note=E3 ubiquitin-protein ligase rififylin
RFFL	Q8WZ73	197	225	1	363	Chain	ID=PRO_0000056025;Note=E3 ubiquitin-protein ligase rififylin
RFFL	Q8WZ73	197	225	1	363	Chain	ID=PRO_0000056025;Note=E3 ubiquitin-protein ligase rififylin
RFFL	Q8WZ73	197	225	1	363	Chain	ID=PRO_0000056025;Note=E3 ubiquitin-protein ligase rififylin
RFFL	Q8WZ73	197	225	197	224	Alternative sequence	ID=VSP_015751;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RFFL	Q8WZ73	197	225	197	224	Alternative sequence	ID=VSP_015751;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RFFL	Q8WZ73	197	225	197	224	Alternative sequence	ID=VSP_015751;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RFFL	Q8WZ73	197	225	197	224	Alternative sequence	ID=VSP_015751;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBFOX3	A6NFN3	138	169	1	312	Chain	ID=PRO_0000349207;Note=RNA binding protein fox-1 homolog 3
RBFOX3	A6NFN3	138	169	100	175	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBFOX3	A6NFN3	138	169	138	138	Site	Note=Interaction with RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBFOX3	A6NFN3	138	169	142	142	Site	Note=Interaction with RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBFOX3	A6NFN3	138	169	166	166	Site	Note=Interaction with RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
RFWD3	Q6PCD5	526	584	1	774	Chain	ID=PRO_0000278234;Note=E3 ubiquitin-protein ligase RFWD3
RFWD3	Q6PCD5	526	584	1	774	Chain	ID=PRO_0000278234;Note=E3 ubiquitin-protein ligase RFWD3
RFWD3	Q6PCD5	526	584	495	537	Repeat	Note=WD 1
RFWD3	Q6PCD5	526	584	495	537	Repeat	Note=WD 1
RFWD3	Q6PCD5	526	584	539	577	Repeat	Note=WD 2
RFWD3	Q6PCD5	526	584	539	577	Repeat	Note=WD 2
RFWD3	Q6PCD5	526	584	583	628	Repeat	Note=WD 3
RFWD3	Q6PCD5	526	584	583	628	Repeat	Note=WD 3
RFWD3	Q6PCD5	526	584	564	564	Natural variant	ID=VAR_030702;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs7193541
RFWD3	Q6PCD5	526	584	564	564	Natural variant	ID=VAR_030702;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs7193541
RFWD3	Q6PCD5	526	584	543	543	Mutagenesis	Note=Abolishes interaction with the RPA complex and subsequent recruitment at DNA damage sites. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575657;Dbxref=PMID:28575657
RFWD3	Q6PCD5	526	584	543	543	Mutagenesis	Note=Abolishes interaction with the RPA complex and subsequent recruitment at DNA damage sites. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575657;Dbxref=PMID:28575657
RFWD3	Q6PCD5	526	584	552	552	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RFWD3	Q6PCD5	526	584	552	552	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RFWD3	Q6PCD5	526	584	520	526	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	520	526	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	527	530	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	527	530	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	531	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	531	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	542	547	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	542	547	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	550	552	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	550	552	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	554	559	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	554	559	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	564	568	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	564	568	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	572	574	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	572	574	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	576	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFWD3	Q6PCD5	526	584	576	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CVZ
RFX2	P48378	260	299	1	723	Chain	ID=PRO_0000215288;Note=DNA-binding protein RFX2
RFX2	P48378	174	199	1	723	Chain	ID=PRO_0000215288;Note=DNA-binding protein RFX2
RFX2	P48378	30	60	1	723	Chain	ID=PRO_0000215288;Note=DNA-binding protein RFX2
RFX2	P48378	260	299	1	723	Chain	ID=PRO_0000215288;Note=DNA-binding protein RFX2
RFX2	P48378	174	199	1	723	Chain	ID=PRO_0000215288;Note=DNA-binding protein RFX2
RFX2	P48378	30	60	1	723	Chain	ID=PRO_0000215288;Note=DNA-binding protein RFX2
RFX2	P48378	260	299	199	274	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX2	P48378	174	199	199	274	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX2	P48378	260	299	199	274	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX2	P48378	174	199	199	274	DNA binding	Note=RFX-type winged-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00858
RFX2	P48378	174	199	175	199	Alternative sequence	ID=VSP_037811;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFX2	P48378	174	199	175	199	Alternative sequence	ID=VSP_037811;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFX2	P48378	30	60	37	37	Natural variant	ID=VAR_036530;Note=In a breast cancer sample%3B somatic mutation. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
RFX2	P48378	30	60	37	37	Natural variant	ID=VAR_036530;Note=In a breast cancer sample%3B somatic mutation. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
RFX2	P48378	30	60	44	44	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RFX2	P48378	30	60	44	44	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPIL2	Q13356	43	63	1	520	Chain	ID=PRO_0000064171;Note=RING-type E3 ubiquitin-protein ligase PPIL2
PPIL2	Q13356	380	398	1	520	Chain	ID=PRO_0000064171;Note=RING-type E3 ubiquitin-protein ligase PPIL2
PPIL2	Q13356	43	63	1	520	Chain	ID=PRO_0000064171;Note=RING-type E3 ubiquitin-protein ligase PPIL2
PPIL2	Q13356	380	398	1	520	Chain	ID=PRO_0000064171;Note=RING-type E3 ubiquitin-protein ligase PPIL2
PPIL2	Q13356	43	63	1	520	Chain	ID=PRO_0000064171;Note=RING-type E3 ubiquitin-protein ligase PPIL2
PPIL2	Q13356	380	398	1	520	Chain	ID=PRO_0000064171;Note=RING-type E3 ubiquitin-protein ligase PPIL2
PPIL2	Q13356	43	63	35	108	Domain	Note=U-box
PPIL2	Q13356	43	63	35	108	Domain	Note=U-box
PPIL2	Q13356	43	63	35	108	Domain	Note=U-box
PPIL2	Q13356	380	398	278	433	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIL2	Q13356	380	398	278	433	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIL2	Q13356	380	398	278	433	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIL2	Q13356	380	398	389	389	Mutagenesis	Note=No peptidyl-prolyl cis-trans isomerase activity%3B enables interaction with cyclosporin A. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20676357;Dbxref=PMID:20676357
PPIL2	Q13356	380	398	389	389	Mutagenesis	Note=No peptidyl-prolyl cis-trans isomerase activity%3B enables interaction with cyclosporin A. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20676357;Dbxref=PMID:20676357
PPIL2	Q13356	380	398	389	389	Mutagenesis	Note=No peptidyl-prolyl cis-trans isomerase activity%3B enables interaction with cyclosporin A. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20676357;Dbxref=PMID:20676357
PPIL2	Q13356	380	398	389	389	Mutagenesis	Note=Gain of a peptidyl-prolyl cis-trans isomerase activity%3B enables interaction with cyclosporin A. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20676357;Dbxref=PMID:20676357
PPIL2	Q13356	380	398	389	389	Mutagenesis	Note=Gain of a peptidyl-prolyl cis-trans isomerase activity%3B enables interaction with cyclosporin A. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20676357;Dbxref=PMID:20676357
PPIL2	Q13356	380	398	389	389	Mutagenesis	Note=Gain of a peptidyl-prolyl cis-trans isomerase activity%3B enables interaction with cyclosporin A. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20676357;Dbxref=PMID:20676357
PPIL2	Q13356	380	398	380	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	380	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	380	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	388	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	388	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	388	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	391	393	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	391	393	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	391	393	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	396	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	396	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
PPIL2	Q13356	380	398	396	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKC
RFXANK	O14593	90	112	1	260	Chain	ID=PRO_0000067049;Note=DNA-binding protein RFXANK
RFXANK	O14593	90	112	1	260	Chain	ID=PRO_0000067049;Note=DNA-binding protein RFXANK
RFXANK	O14593	90	112	89	118	Repeat	Note=ANK 1
RFXANK	O14593	90	112	89	118	Repeat	Note=ANK 1
RFXANK	O14593	90	112	91	113	Alternative sequence	ID=VSP_000284;Note=In isoform 2 and isoform 3. SLSIHQLAAQGELDQLKEHLRKG->C;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10072068,ECO:0000303|PubMed:15489334;Dbxref=PMID:10072068,PMID:15489334
RFXANK	O14593	90	112	91	113	Alternative sequence	ID=VSP_000284;Note=In isoform 2 and isoform 3. SLSIHQLAAQGELDQLKEHLRKG->C;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10072068,ECO:0000303|PubMed:15489334;Dbxref=PMID:10072068,PMID:15489334
RFXANK	O14593	90	112	94	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V30
RFXANK	O14593	90	112	94	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V30
RFXANK	O14593	90	112	103	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V30
RFXANK	O14593	90	112	103	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V30
PPIL6	Q8IXY8	210	229	1	311	Chain	ID=PRO_0000263755;Note=Problable inactive peptidyl-prolyl cis-trans isomerase-like 6
PPIL6	Q8IXY8	140	161	1	311	Chain	ID=PRO_0000263755;Note=Problable inactive peptidyl-prolyl cis-trans isomerase-like 6
PPIL6	Q8IXY8	77	140	1	311	Chain	ID=PRO_0000263755;Note=Problable inactive peptidyl-prolyl cis-trans isomerase-like 6
PPIL6	Q8IXY8	210	229	145	308	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIL6	Q8IXY8	140	161	145	308	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIL6	Q8IXY8	77	140	46	77	Alternative sequence	ID=VSP_055658;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPIL6	Q8IXY8	210	229	229	229	Alternative sequence	ID=VSP_043036;Note=In isoform 2. E->EELYGSLKRSVKRQKESRGVGKIEKYR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PPIL6	Q8IXY8	77	140	110	110	Natural variant	ID=VAR_029620;Note=H->R;Dbxref=dbSNP:rs9398200
PSTPIP2	Q9H939	214	247	1	334	Chain	ID=PRO_0000058541;Note=Proline-serine-threonine phosphatase-interacting protein 2
PSTPIP2	Q9H939	118	139	1	334	Chain	ID=PRO_0000058541;Note=Proline-serine-threonine phosphatase-interacting protein 2
PSTPIP2	Q9H939	45	70	1	334	Chain	ID=PRO_0000058541;Note=Proline-serine-threonine phosphatase-interacting protein 2
PSTPIP2	Q9H939	214	247	4	264	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
PSTPIP2	Q9H939	118	139	4	264	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
PSTPIP2	Q9H939	45	70	4	264	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
PSTPIP2	Q9H939	118	139	66	166	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PSTPIP2	Q9H939	45	70	66	166	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RACGAP1	Q9H0H5	293	348	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	183	210	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	293	348	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	183	210	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	293	348	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	183	210	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	293	348	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	183	210	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	293	348	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	183	210	1	632	Chain	ID=PRO_0000228808;Note=Rac GTPase-activating protein 1
RACGAP1	Q9H0H5	293	348	286	335	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
RACGAP1	Q9H0H5	293	348	286	335	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
RACGAP1	Q9H0H5	293	348	286	335	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
RACGAP1	Q9H0H5	293	348	286	335	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
RACGAP1	Q9H0H5	293	348	286	335	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
RACGAP1	Q9H0H5	183	210	106	285	Region	Note=Interaction with SLC26A8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278976;Dbxref=PMID:11278976
RACGAP1	Q9H0H5	183	210	106	285	Region	Note=Interaction with SLC26A8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278976;Dbxref=PMID:11278976
RACGAP1	Q9H0H5	183	210	106	285	Region	Note=Interaction with SLC26A8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278976;Dbxref=PMID:11278976
RACGAP1	Q9H0H5	183	210	106	285	Region	Note=Interaction with SLC26A8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278976;Dbxref=PMID:11278976
RACGAP1	Q9H0H5	183	210	106	285	Region	Note=Interaction with SLC26A8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278976;Dbxref=PMID:11278976
RACGAP1	Q9H0H5	183	210	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
RACGAP1	Q9H0H5	183	210	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
RACGAP1	Q9H0H5	183	210	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
RACGAP1	Q9H0H5	183	210	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
RACGAP1	Q9H0H5	183	210	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
RACGAP1	Q9H0H5	183	210	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
RACGAP1	Q9H0H5	183	210	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
RACGAP1	Q9H0H5	183	210	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
RACGAP1	Q9H0H5	183	210	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
RACGAP1	Q9H0H5	183	210	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
RACGAP1	Q9H0H5	293	348	342	342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
RACGAP1	Q9H0H5	293	348	342	342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
RACGAP1	Q9H0H5	293	348	342	342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
RACGAP1	Q9H0H5	293	348	342	342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
RACGAP1	Q9H0H5	293	348	342	342	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
RACGAP1	Q9H0H5	293	348	306	306	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	306	306	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	306	306	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	306	306	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	306	306	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	309	309	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	309	309	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	309	309	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	309	309	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	309	309	Mutagenesis	Note=Cytokinesis failure. Abolishes localization at the cell membrane. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	316	316	Mutagenesis	Note=Cytokinesis failure. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	316	316	Mutagenesis	Note=Cytokinesis failure. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	316	316	Mutagenesis	Note=Cytokinesis failure. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	316	316	Mutagenesis	Note=Cytokinesis failure. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	316	316	Mutagenesis	Note=Cytokinesis failure. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235882;Dbxref=PMID:23235882
RACGAP1	Q9H0H5	293	348	289	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	289	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	289	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	289	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	289	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	301	303	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	301	303	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	301	303	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	301	303	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	301	303	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	312	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	312	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	312	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	312	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	312	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	325	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	325	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	325	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	325	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
RACGAP1	Q9H0H5	293	348	325	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6D
PPM1F	P49593	249	297	1	454	Chain	ID=PRO_0000057758;Note=Protein phosphatase 1F
PPM1F	P49593	249	297	156	413	Domain	Note=PPM-type phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01082
PPM1F	P49593	249	297	296	296	Natural variant	ID=VAR_036520;Note=In a colorectal cancer sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
PLEKHA6	Q9Y2H5	608	640	1	1048	Chain	ID=PRO_0000053884;Note=Pleckstrin homology domain-containing family A member 6
PLEKHA6	Q9Y2H5	508	531	1	1048	Chain	ID=PRO_0000053884;Note=Pleckstrin homology domain-containing family A member 6
PKP1	Q13835	411	431	1	747	Chain	ID=PRO_0000064284;Note=Plakophilin-1
PKP1	Q13835	470	522	1	747	Chain	ID=PRO_0000064284;Note=Plakophilin-1
PKP1	Q13835	411	431	1	747	Chain	ID=PRO_0000064284;Note=Plakophilin-1
PKP1	Q13835	470	522	1	747	Chain	ID=PRO_0000064284;Note=Plakophilin-1
PKP1	Q13835	411	431	360	415	Repeat	Note=ARM 4
PKP1	Q13835	411	431	360	415	Repeat	Note=ARM 4
PKP1	Q13835	411	431	416	463	Repeat	Note=ARM 5
PKP1	Q13835	411	431	416	463	Repeat	Note=ARM 5
PKP1	Q13835	411	431	412	432	Alternative sequence	ID=VSP_006735;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7527055,ECO:0000303|PubMed:9369526;Dbxref=PMID:15489334,PMID:7527055,PMID:9369526
PKP1	Q13835	411	431	412	432	Alternative sequence	ID=VSP_006735;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7527055,ECO:0000303|PubMed:9369526;Dbxref=PMID:15489334,PMID:7527055,PMID:9369526
PKP1	Q13835	411	431	415	415	Natural variant	ID=VAR_053811;Note=G->D;Dbxref=dbSNP:rs1626370
PKP1	Q13835	411	431	415	415	Natural variant	ID=VAR_053811;Note=G->D;Dbxref=dbSNP:rs1626370
PKP1	Q13835	470	522	496	496	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKP1	Q13835	470	522	496	496	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKP1	Q13835	470	522	506	506	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKP1	Q13835	470	522	506	506	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKP1	Q13835	411	431	400	411	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	411	431	400	411	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	472	482	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	472	482	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	483	485	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	483	485	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	486	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	486	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	493	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKP1	Q13835	470	522	493	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XM9
PKD1	P98161	2305	2355	24	4303	Chain	ID=PRO_0000024298;Note=Polycystin-1
PKD1	P98161	96	119	24	4303	Chain	ID=PRO_0000024298;Note=Polycystin-1
PKD1	P98161	2305	2355	24	3074	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKD1	P98161	96	119	24	3074	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKD1	P98161	96	119	92	113	Repeat	Note=LRR 2
PKD1	P98161	2305	2355	2146	2833	Domain	Note=REJ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00511
PKD1	P98161	96	119	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKD1	P98161	2305	2355	2353	2353	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKD1	P98161	96	119	97	97	Natural variant	ID=VAR_064380;Note=In PKD1. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21115670;Dbxref=PMID:21115670
PKD1	P98161	96	119	99	99	Natural variant	ID=VAR_058762;Note=In PKD1%3B unknown pathological significance. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18837007;Dbxref=PMID:18837007
PKD1	P98161	2305	2355	2329	2329	Natural variant	ID=VAR_011039;Note=In PKD1%3B unknown pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10854095;Dbxref=dbSNP:rs200433577,PMID:10854095
PKD1	P98161	2305	2355	2336	2336	Natural variant	ID=VAR_011040;Note=In PKD1. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11115377;Dbxref=PMID:11115377
AGPAT4	Q9NRZ5	116	170	1	378	Chain	ID=PRO_0000208197;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase delta
AGPAT4	Q9NRZ5	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT4	Q9NRZ5	116	170	61	222	Alternative sequence	ID=VSP_056929;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLCG1	P19174	199	227	2	1290	Chain	ID=PRO_0000088498;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase gamma-1
PLCG1	P19174	767	793	2	1290	Chain	ID=PRO_0000088498;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase gamma-1
PLCG1	P19174	767	793	791	851	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
PLCG1	P19174	767	793	771	771	Modified residue	Note=Phosphotyrosine%3B by SYK;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:15144186,ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:20494825,ECO:0000269|PubMed:8657103;Dbxref=PMID:15144186,PMID:19690332,PMID:20494825,PMID:8657103
PLCG1	P19174	767	793	775	775	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PLCG1	P19174	767	793	783	783	Modified residue	Note=Phosphotyrosine%3B by ITK%2C SYK and TXK;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:11564877,ECO:0000269|PubMed:15215251,ECO:0000269|PubMed:8657103;Dbxref=PMID:19690332,PMID:11564877,PMID:15215251,PMID:8657103
PLCG1	P19174	199	227	209	209	Natural variant	ID=VAR_025213;Note=T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs2229348
PLCG1	P19174	767	793	792	794	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HSQ
PLD3	Q8IV08	9	34	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	226	293	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	9	34	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	226	293	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	9	34	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	226	293	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	9	34	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	226	293	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	9	34	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	226	293	1	490	Chain	ID=PRO_0000280326;Note=Phospholipase D3
PLD3	Q8IV08	9	34	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	9	34	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	9	34	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	9	34	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	9	34	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	226	293	60	490	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	226	293	60	490	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	226	293	60	490	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	226	293	60	490	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	226	293	60	490	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLD3	Q8IV08	226	293	232	232	Natural variant	ID=VAR_071186;Note=Found in Alzheimer disease patients at higher frequency compared to controls%3B unknown pathological significance. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24336208,ECO:0000269|PubMed:25832410,ECO:0000269|PubMed:25832411,ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs145999145,PMID:24336208,PMID:25832410,PMID:25832411,PMID:26411346
PLD3	Q8IV08	226	293	232	232	Natural variant	ID=VAR_071186;Note=Found in Alzheimer disease patients at higher frequency compared to controls%3B unknown pathological significance. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24336208,ECO:0000269|PubMed:25832410,ECO:0000269|PubMed:25832411,ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs145999145,PMID:24336208,PMID:25832410,PMID:25832411,PMID:26411346
PLD3	Q8IV08	226	293	232	232	Natural variant	ID=VAR_071186;Note=Found in Alzheimer disease patients at higher frequency compared to controls%3B unknown pathological significance. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24336208,ECO:0000269|PubMed:25832410,ECO:0000269|PubMed:25832411,ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs145999145,PMID:24336208,PMID:25832410,PMID:25832411,PMID:26411346
PLD3	Q8IV08	226	293	232	232	Natural variant	ID=VAR_071186;Note=Found in Alzheimer disease patients at higher frequency compared to controls%3B unknown pathological significance. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24336208,ECO:0000269|PubMed:25832410,ECO:0000269|PubMed:25832411,ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs145999145,PMID:24336208,PMID:25832410,PMID:25832411,PMID:26411346
PLD3	Q8IV08	226	293	232	232	Natural variant	ID=VAR_071186;Note=Found in Alzheimer disease patients at higher frequency compared to controls%3B unknown pathological significance. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24336208,ECO:0000269|PubMed:25832410,ECO:0000269|PubMed:25832411,ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs145999145,PMID:24336208,PMID:25832410,PMID:25832411,PMID:26411346
PLD3	Q8IV08	226	293	242	242	Natural variant	ID=VAR_075913;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs757965784,PMID:26411346
PLD3	Q8IV08	226	293	242	242	Natural variant	ID=VAR_075913;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs757965784,PMID:26411346
PLD3	Q8IV08	226	293	242	242	Natural variant	ID=VAR_075913;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs757965784,PMID:26411346
PLD3	Q8IV08	226	293	242	242	Natural variant	ID=VAR_075913;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs757965784,PMID:26411346
PLD3	Q8IV08	226	293	242	242	Natural variant	ID=VAR_075913;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs757965784,PMID:26411346
PLD3	Q8IV08	226	293	249	249	Natural variant	ID=VAR_075914;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs746715924,PMID:26411346
PLD3	Q8IV08	226	293	249	249	Natural variant	ID=VAR_075914;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs746715924,PMID:26411346
PLD3	Q8IV08	226	293	249	249	Natural variant	ID=VAR_075914;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs746715924,PMID:26411346
PLD3	Q8IV08	226	293	249	249	Natural variant	ID=VAR_075914;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs746715924,PMID:26411346
PLD3	Q8IV08	226	293	249	249	Natural variant	ID=VAR_075914;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs746715924,PMID:26411346
PLD3	Q8IV08	226	293	272	272	Natural variant	ID=VAR_075915;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs144312764,PMID:26411346
PLD3	Q8IV08	226	293	272	272	Natural variant	ID=VAR_075915;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs144312764,PMID:26411346
PLD3	Q8IV08	226	293	272	272	Natural variant	ID=VAR_075915;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs144312764,PMID:26411346
PLD3	Q8IV08	226	293	272	272	Natural variant	ID=VAR_075915;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs144312764,PMID:26411346
PLD3	Q8IV08	226	293	272	272	Natural variant	ID=VAR_075915;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs144312764,PMID:26411346
PLD3	Q8IV08	226	293	284	284	Natural variant	ID=VAR_075916;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs200274020,PMID:26411346
PLD3	Q8IV08	226	293	284	284	Natural variant	ID=VAR_075916;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs200274020,PMID:26411346
PLD3	Q8IV08	226	293	284	284	Natural variant	ID=VAR_075916;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs200274020,PMID:26411346
PLD3	Q8IV08	226	293	284	284	Natural variant	ID=VAR_075916;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs200274020,PMID:26411346
PLD3	Q8IV08	226	293	284	284	Natural variant	ID=VAR_075916;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs200274020,PMID:26411346
PLD3	Q8IV08	226	293	293	293	Natural variant	ID=VAR_075917;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs368737000,PMID:26411346
PLD3	Q8IV08	226	293	293	293	Natural variant	ID=VAR_075917;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs368737000,PMID:26411346
PLD3	Q8IV08	226	293	293	293	Natural variant	ID=VAR_075917;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs368737000,PMID:26411346
PLD3	Q8IV08	226	293	293	293	Natural variant	ID=VAR_075917;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs368737000,PMID:26411346
PLD3	Q8IV08	226	293	293	293	Natural variant	ID=VAR_075917;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411346;Dbxref=dbSNP:rs368737000,PMID:26411346
PLCH1	Q4KWH8	861	881	1	1693	Chain	ID=PRO_0000329007;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase eta-1
PLCH1	Q4KWH8	679	715	1	1693	Chain	ID=PRO_0000329007;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase eta-1
PLCH1	Q4KWH8	532	556	1	1693	Chain	ID=PRO_0000329007;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase eta-1
PLCH1	Q4KWH8	679	715	601	714	Domain	Note=PI-PLC Y-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00271
PLCH1	Q4KWH8	861	881	862	881	Alternative sequence	ID=VSP_032902;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PLEK	P08567	254	282	1	350	Chain	ID=PRO_0000053859;Note=Pleckstrin
PLEK	P08567	254	282	244	347	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEK	P08567	254	282	245	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I5F
PLEK	P08567	254	282	256	258	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I5F
PLEK	P08567	254	282	261	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I5F
PLEK	P08567	254	282	270	273	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I5F
PLEK	P08567	254	282	274	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I5F
PLEK	P08567	254	282	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZM0
PLP2	Q04941	32	83	1	152	Chain	ID=PRO_0000156819;Note=Proteolipid protein 2
PLP2	Q04941	83	115	1	152	Chain	ID=PRO_0000156819;Note=Proteolipid protein 2
PLP2	Q04941	32	83	25	45	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLP2	Q04941	32	83	48	68	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLP2	Q04941	83	115	85	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLP2	Q04941	83	115	112	132	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLP2	Q04941	32	83	19	137	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
PLP2	Q04941	83	115	19	137	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
PLP2	Q04941	83	115	108	108	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLP2	Q04941	83	115	91	91	Natural variant	ID=VAR_011924;Note=A->S;Dbxref=dbSNP:rs1802969
PLXNB1	O43157	2076	2101	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	1206	1264	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	944	985	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	903	944	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	676	903	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	430	473	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	369	430	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	2076	2101	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	1206	1264	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	944	985	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	903	944	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	676	903	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	430	473	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	369	430	20	2135	Chain	ID=PRO_0000024671;Note=Plexin-B1
PLXNB1	O43157	1206	1264	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	944	985	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	903	944	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	676	903	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	430	473	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	369	430	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	1206	1264	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	944	985	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	903	944	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	676	903	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	430	473	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	369	430	20	1490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	2076	2101	1512	2135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	2076	2101	1512	2135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB1	O43157	430	473	20	479	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB1	O43157	369	430	20	479	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB1	O43157	430	473	20	479	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB1	O43157	369	430	20	479	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB1	O43157	1206	1264	1162	1249	Domain	Note=IPT/TIG 2
PLXNB1	O43157	1206	1264	1162	1249	Domain	Note=IPT/TIG 2
PLXNB1	O43157	1206	1264	1252	1375	Domain	Note=IPT/TIG 3
PLXNB1	O43157	1206	1264	1252	1375	Domain	Note=IPT/TIG 3
PLXNB1	O43157	676	903	678	829	Compositional bias	Note=Pro-rich
PLXNB1	O43157	676	903	678	829	Compositional bias	Note=Pro-rich
PLXNB1	O43157	1206	1264	1253	1253	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:16335952,PMID:19159218,PMID:19349973
PLXNB1	O43157	1206	1264	1253	1253	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:16335952,PMID:19159218,PMID:19349973
PLXNB1	O43157	369	430	252	377	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB1	O43157	369	430	252	377	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB1	O43157	676	903	677	729	Alternative sequence	ID=VSP_011513;Note=In isoform 3. SPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGAS->VMETQQSLRALPPPSSSRPASTTSMTPPGSGSWKRRPWGQAPAPVWRAFRAPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	676	903	677	729	Alternative sequence	ID=VSP_011513;Note=In isoform 3. SPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGAS->VMETQQSLRALPPPSSSRPASTTSMTPPGSGSWKRRPWGQAPAPVWRAFRAPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	676	903	688	870	Alternative sequence	ID=VSP_011514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	676	903	688	870	Alternative sequence	ID=VSP_011514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	2076	2101	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	1206	1264	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	944	985	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	903	944	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	676	903	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	2076	2101	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	1206	1264	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	944	985	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	903	944	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	676	903	730	2135	Alternative sequence	ID=VSP_011515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10520995;Dbxref=PMID:10520995
PLXNB1	O43157	369	430	389	389	Natural variant	ID=VAR_050598;Note=R->W;Dbxref=dbSNP:rs34050056
PLXNB1	O43157	369	430	389	389	Natural variant	ID=VAR_050598;Note=R->W;Dbxref=dbSNP:rs34050056
PLXNB1	O43157	676	903	753	753	Natural variant	ID=VAR_050599;Note=S->L;Dbxref=dbSNP:rs35592743
PLXNB1	O43157	676	903	753	753	Natural variant	ID=VAR_050599;Note=S->L;Dbxref=dbSNP:rs35592743
PLXNB1	O43157	369	430	370	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	370	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	385	390	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	385	390	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	392	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	392	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	397	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	397	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	405	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	405	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	416	423	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	416	423	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	430	473	426	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	426	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	430	473	426	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	369	430	426	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	430	473	434	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OL2
PLXNB1	O43157	430	473	434	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OL2
PLXNB1	O43157	430	473	442	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	430	473	442	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	430	473	463	469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	430	473	463	469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B4W
PLXNB1	O43157	2076	2101	2064	2076	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HM6
PLXNB1	O43157	2076	2101	2064	2076	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HM6
PLXNB1	O43157	2076	2101	2084	2097	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HM6
PLXNB1	O43157	2076	2101	2084	2097	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HM6
PLXNB1	O43157	2076	2101	2099	2107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HM6
PLXNB1	O43157	2076	2101	2099	2107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HM6
RCOR1	Q9UKL0	120	148	1	485	Chain	ID=PRO_0000226773;Note=REST corepressor 1
RCOR1	Q9UKL0	166	220	1	485	Chain	ID=PRO_0000226773;Note=REST corepressor 1
RCOR1	Q9UKL0	120	148	103	189	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
RCOR1	Q9UKL0	166	220	103	189	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
RCOR1	Q9UKL0	166	220	190	241	Domain	Note=SANT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
RCOR1	Q9UKL0	120	148	78	257	Region	Note=Interaction with HDAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11516394;Dbxref=PMID:11516394
RCOR1	Q9UKL0	166	220	78	257	Region	Note=Interaction with HDAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11516394;Dbxref=PMID:11516394
RCOR1	Q9UKL0	120	148	127	127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
RCOR1	Q9UKL0	120	148	122	122	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RCOR2	Q8IZ40	225	297	1	523	Chain	ID=PRO_0000226776;Note=REST corepressor 2
RCOR2	Q8IZ40	225	297	283	314	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRDX4	Q13162	120	158	38	271	Chain	ID=PRO_0000135098;Note=Peroxiredoxin-4
PRDX4	Q13162	159	199	38	271	Chain	ID=PRO_0000135098;Note=Peroxiredoxin-4
PRDX4	Q13162	120	158	79	237	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PRDX4	Q13162	159	199	79	237	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PRDX4	Q13162	120	158	124	124	Active site	Note=Cysteine sulfenic acid (-SOH) intermediate;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12059788,ECO:0000305|PubMed:21916849;Dbxref=PMID:12059788,PMID:21916849
PRDX4	Q13162	120	158	124	124	Disulfide bond	Note=Interchain (with C-245)%3B in linked form;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3TJB,ECO:0000244|PDB:3TJG,ECO:0000269|PubMed:21994946;Dbxref=PMID:21994946
PRDX4	Q13162	120	158	123	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	120	158	135	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	120	158	140	142	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	120	158	143	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	120	158	153	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	159	199	153	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	159	199	164	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	159	199	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	159	199	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HQP
PRDX4	Q13162	159	199	183	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	159	199	193	195	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PRDX4	Q13162	159	199	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PN8
PPP6R1	Q9UPN7	857	880	1	881	Chain	ID=PRO_0000046096;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 1
PPP6R1	Q9UPN7	387	432	1	881	Chain	ID=PRO_0000046096;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 1
PPP6R1	Q9UPN7	336	387	1	881	Chain	ID=PRO_0000046096;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 1
PPP6R1	Q9UPN7	857	880	1	881	Chain	ID=PRO_0000046096;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 1
PPP6R1	Q9UPN7	387	432	1	881	Chain	ID=PRO_0000046096;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 1
PPP6R1	Q9UPN7	336	387	1	881	Chain	ID=PRO_0000046096;Note=Serine/threonine-protein phosphatase 6 regulatory subunit 1
PPP6R1	Q9UPN7	387	432	10	403	Region	Note=Interaction with PPP6C
PPP6R1	Q9UPN7	336	387	10	403	Region	Note=Interaction with PPP6C
PPP6R1	Q9UPN7	387	432	10	403	Region	Note=Interaction with PPP6C
PPP6R1	Q9UPN7	336	387	10	403	Region	Note=Interaction with PPP6C
PPP6R1	Q9UPN7	857	880	697	878	Compositional bias	Note=Pro-rich
PPP6R1	Q9UPN7	857	880	697	878	Compositional bias	Note=Pro-rich
ACPP	P15309	72	101	33	386	Chain	ID=PRO_0000023963;Note=Prostatic acid phosphatase
ACPP	P15309	152	185	33	386	Chain	ID=PRO_0000023963;Note=Prostatic acid phosphatase
ACPP	P15309	72	101	94	94	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10639192;Dbxref=PMID:10639192
ACPP	P15309	152	185	161	372	Disulfide bond	.
ACPP	P15309	152	185	153	185	Alternative sequence	ID=VSP_053360;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.7;Dbxref=PMID:14702039
ACPP	P15309	72	101	66	73	Sequence conflict	Note=GFGQLTQL->RIWPTHPA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACPP	P15309	72	101	66	73	Sequence conflict	Note=GFGQLTQL->WIWPTHPA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACPP	P15309	72	101	95	95	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACPP	P15309	152	185	157	157	Sequence conflict	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACPP	P15309	72	101	72	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	72	101	89	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	72	101	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	152	185	152	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	152	185	162	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	152	185	175	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	152	185	182	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
ACPP	P15309	152	185	185	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND6
RPA2	P15927	111	136	1	270	Chain	ID=PRO_0000097270;Note=Replication protein A 32 kDa subunit
RPA2	P15927	73	111	1	270	Chain	ID=PRO_0000097270;Note=Replication protein A 32 kDa subunit
RPA2	P15927	111	136	74	148	DNA binding	Note=OB
RPA2	P15927	73	111	74	148	DNA binding	Note=OB
RPA2	P15927	111	136	95	123	Compositional bias	Note=Asp/Glu-rich (acidic)
RPA2	P15927	73	111	95	123	Compositional bias	Note=Asp/Glu-rich (acidic)
RPA2	P15927	111	136	127	145	Compositional bias	Note=Arg/Lys-rich (basic)
RPA2	P15927	73	111	73	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA2	P15927	73	111	87	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA2	P15927	73	111	97	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA2	P15927	73	111	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RPA2	P15927	111	136	125	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KDF
RASGEF1B	Q0VAM2	368	400	1	473	Chain	ID=PRO_0000297638;Note=Ras-GEF domain-containing family member 1B
RASGEF1B	Q0VAM2	59	100	1	473	Chain	ID=PRO_0000297638;Note=Ras-GEF domain-containing family member 1B
RASGEF1B	Q0VAM2	59	100	34	164	Domain	Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135
RASGEF1B	Q0VAM2	368	400	204	452	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RASGEF1B	Q0VAM2	59	100	60	100	Alternative sequence	ID=VSP_027313;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPM1M	Q96MI6	165	201	1	270	Chain	ID=PRO_0000057756;Note=Protein phosphatase 1M
PPM1M	Q96MI6	165	201	1	270	Domain	Note=PPM-type phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01082
PPM1M	Q96MI6	165	201	124	270	Alternative sequence	ID=VSP_050664;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP1R32	Q7Z5V6	229	249	1	425	Chain	ID=PRO_0000274377;Note=Protein phosphatase 1 regulatory subunit 32
PPP1R32	Q7Z5V6	249	278	1	425	Chain	ID=PRO_0000274377;Note=Protein phosphatase 1 regulatory subunit 32
PPP1R32	Q7Z5V6	348	402	1	425	Chain	ID=PRO_0000274377;Note=Protein phosphatase 1 regulatory subunit 32
PPP1R32	Q7Z5V6	229	249	230	249	Alternative sequence	ID=VSP_022731;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP1R32	Q7Z5V6	249	278	230	249	Alternative sequence	ID=VSP_022731;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP1R32	Q7Z5V6	229	249	238	238	Natural variant	ID=VAR_030271;Note=T->N;Dbxref=dbSNP:rs11230707
PPP1R32	Q7Z5V6	348	402	382	382	Natural variant	ID=VAR_030272;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12787061,PMID:15489334
PRC1	O43663	583	597	1	620	Chain	ID=PRO_0000229737;Note=Protein regulator of cytokinesis 1
PRC1	O43663	487	524	1	620	Chain	ID=PRO_0000229737;Note=Protein regulator of cytokinesis 1
PRC1	O43663	450	487	1	620	Chain	ID=PRO_0000229737;Note=Protein regulator of cytokinesis 1
PRC1	O43663	369	401	1	620	Chain	ID=PRO_0000229737;Note=Protein regulator of cytokinesis 1
PRC1	O43663	167	224	1	620	Chain	ID=PRO_0000229737;Note=Protein regulator of cytokinesis 1
PRC1	O43663	48	89	1	620	Chain	ID=PRO_0000229737;Note=Protein regulator of cytokinesis 1
PRC1	O43663	167	224	1	341	Region	Note=Dimerization
PRC1	O43663	48	89	1	341	Region	Note=Dimerization
PRC1	O43663	450	487	342	466	Region	Note=Spectrin-fold
PRC1	O43663	369	401	342	466	Region	Note=Spectrin-fold
PRC1	O43663	583	597	467	620	Region	Note=Unstructured%2C Arg/Lys rich
PRC1	O43663	487	524	467	620	Region	Note=Unstructured%2C Arg/Lys rich
PRC1	O43663	450	487	467	620	Region	Note=Unstructured%2C Arg/Lys rich
PRC1	O43663	167	224	211	304	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRC1	O43663	450	487	383	463	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRC1	O43663	369	401	383	463	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRC1	O43663	369	401	377	377	Binding site	Note=Tubulin
PRC1	O43663	369	401	387	387	Binding site	Note=Tubulin
PRC1	O43663	450	487	470	470	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:17351640,ECO:0000269|PubMed:17438553,ECO:0000269|PubMed:9885575;Dbxref=PMID:23186163,PMID:17351640,PMID:17438553,PMID:9885575
PRC1	O43663	450	487	481	481	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:17351640,ECO:0000269|PubMed:17438553,ECO:0000269|PubMed:9885575;Dbxref=PMID:23186163,PMID:17351640,PMID:17438553,PMID:9885575
PRC1	O43663	487	524	513	513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PRC1	O43663	48	89	50	90	Alternative sequence	ID=VSP_035875;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRC1	O43663	369	401	397	426	Alternative sequence	ID=VSP_051979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRC1	O43663	583	597	558	620	Alternative sequence	ID=VSP_035876;Note=In isoform 3. GGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQRELSKASKSDATSGILNSTNIQS->ARTFKGFQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRC1	O43663	583	597	584	597	Alternative sequence	ID=VSP_051980;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
PRC1	O43663	167	224	187	187	Natural variant	ID=VAR_047768;Note=A->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9885575;Dbxref=dbSNP:rs7172758,PMID:14702039,PMID:15489334,PMID:9885575
PRC1	O43663	487	524	511	511	Natural variant	ID=VAR_047769;Note=Y->C;Dbxref=dbSNP:rs12911192
PRC1	O43663	450	487	470	470	Mutagenesis	Note=No effect. Abolishes CDK1-mediated phosphorylation%2C leading to prematurely recruit PLK1 to the spindle during prometaphase and blocking mitotic progression%3B when associated with A-481. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12082078,ECO:0000269|PubMed:17351640,ECO:0000269|PubMed:9885575;Dbxref=PMID:12082078,PMID:17351640,PMID:9885575
PRC1	O43663	450	487	481	481	Mutagenesis	Note=No effect. Reduces in vitro cyclin E-CDK2 phosphorylation and causes extensive bundling of microtubules to the mitotic spindle%3B when associated with A-470. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12082078,ECO:0000269|PubMed:17351640,ECO:0000269|PubMed:9885575;Dbxref=PMID:12082078,PMID:17351640,PMID:9885575
PRC1	O43663	48	89	33	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Y
PRC1	O43663	167	224	150	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Y
PRC1	O43663	167	224	195	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Y
PRC1	O43663	167	224	212	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Y
PRC1	O43663	369	401	347	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NRX
PRC1	O43663	369	401	375	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NRY
PRC1	O43663	369	401	385	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NRX
PRC1	O43663	450	487	428	464	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NRX
PRRC2B	Q5JSZ5	775	1468	1	2229	Chain	ID=PRO_0000274481;Note=Protein PRRC2B
PRRC2B	Q5JSZ5	1661	1725	1	2229	Chain	ID=PRO_0000274481;Note=Protein PRRC2B
PRRC2B	Q5JSZ5	775	1468	1132	1132	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRRC2B	Q5JSZ5	775	1468	1231	1231	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRRC2B	Q5JSZ5	775	1468	963	963	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
PRRC2B	Q5JSZ5	775	1468	1	1903	Alternative sequence	ID=VSP_022760;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
PRRC2B	Q5JSZ5	1661	1725	1	1903	Alternative sequence	ID=VSP_022760;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
PRRC2B	Q5JSZ5	775	1468	775	1468	Alternative sequence	ID=VSP_039905;Note=In isoform 1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRRC2B	Q5JSZ5	1661	1725	1675	1675	Natural variant	ID=VAR_030290;Note=L->P;Dbxref=dbSNP:rs10751478
PRRC2B	Q5JSZ5	775	1468	936	936	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRRC2B	Q5JSZ5	775	1468	981	981	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRRC2B	Q5JSZ5	775	1468	1044	1044	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRRC2B	Q5JSZ5	775	1468	1276	1276	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRDM5	Q9NQX1	541	576	1	630	Chain	ID=PRO_0000047761;Note=PR domain zinc finger protein 5
PRDM5	Q9NQX1	217	247	1	630	Chain	ID=PRO_0000047761;Note=PR domain zinc finger protein 5
PRDM5	Q9NQX1	59	100	1	630	Chain	ID=PRO_0000047761;Note=PR domain zinc finger protein 5
PRDM5	Q9NQX1	31	59	1	630	Chain	ID=PRO_0000047761;Note=PR domain zinc finger protein 5
PRDM5	Q9NQX1	59	100	8	124	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
PRDM5	Q9NQX1	31	59	8	124	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
PRDM5	Q9NQX1	217	247	199	221	Zinc finger	Note=C2H2-type 2%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM5	Q9NQX1	217	247	234	256	Zinc finger	Note=C2H2-type 3%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM5	Q9NQX1	541	576	545	567	Zinc finger	Note=C2H2-type 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM5	Q9NQX1	541	576	573	595	Zinc finger	Note=C2H2-type 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM5	Q9NQX1	541	576	112	630	Alternative sequence	ID=VSP_035653;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PRDM5	Q9NQX1	217	247	112	630	Alternative sequence	ID=VSP_035653;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PRDM5	Q9NQX1	217	247	218	248	Alternative sequence	ID=VSP_035654;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRDM5	Q9NQX1	541	576	533	630	Alternative sequence	ID=VSP_054396;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RABAC1	Q9UI14	122	156	1	185	Chain	ID=PRO_0000220878;Note=Prenylated Rab acceptor protein 1
RABAC1	Q9UI14	122	156	113	131	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABAC1	Q9UI14	122	156	132	148	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABAC1	Q9UI14	122	156	149	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABAC1	Q9UI14	122	156	129	129	Sequence conflict	Note=A->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS28	P62857	13	29	1	69	Chain	ID=PRO_0000136822;Note=40S ribosomal protein S28
RPLP2	P05387	57	90	1	115	Chain	ID=PRO_0000157640;Note=60S acidic ribosomal protein P2
RPLP2	P05387	57	90	1	115	Chain	ID=PRO_0000157640;Note=60S acidic ribosomal protein P2
RPLP2	P05387	57	90	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:24275569
RPLP2	P05387	57	90	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:24275569
RPLP2	P05387	57	90	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
RPLP2	P05387	57	90	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
RPLP2	P05387	57	90	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBF
RPLP2	P05387	57	90	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBF
RPLP2	P05387	57	90	63	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BEH
RPLP2	P05387	57	90	63	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BEH
RPLP0	P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPLP0	P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPLP0	P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPL9	Q9BYD2	196	224	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
MRPL9	Q9BYD2	162	196	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
MRPL9	Q9BYD2	145	162	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
MRPL9	Q9BYD2	196	224	210	210	Natural variant	ID=VAR_028137;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11279069;Dbxref=dbSNP:rs8480,PMID:11279069
MRPL48	Q96GC5	158	188	29	212	Chain	ID=PRO_0000261657;Note=39S ribosomal protein L48%2C mitochondrial
MRPL48	Q96GC5	158	188	164	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
RPL23A	P62750	70	128	2	156	Chain	ID=PRO_0000129467;Note=60S ribosomal protein L23a
RPL23A	P62750	70	128	70	70	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62751
RPL23A	P62750	70	128	99	99	Natural variant	ID=VAR_069221;Note=Rare variant found in Diamond-Blackfan anemia patients%3B unknown pathological significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22431104;Dbxref=dbSNP:rs151327030,PMID:22431104
RPL23A	P62750	70	128	78	78	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL23A	P62750	70	128	110	110	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL3	P39023	349	389	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
RPL3	P39023	317	349	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
RPL3	P39023	283	317	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
RPL3	P39023	283	317	286	286	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27659
RPL3	P39023	283	317	294	294	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL3	P39023	283	317	304	304	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
RPL3	P39023	349	389	366	366	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL3	P39023	349	389	373	373	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27659
RPL3	P39023	283	317	286	286	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL3	P39023	283	317	294	294	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
RPL3	P39023	349	389	366	366	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL3	P39023	349	389	386	386	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL7	P18124	97	142	1	248	Chain	ID=PRO_0000104633;Note=60S ribosomal protein L7
RPL7	P18124	97	142	124	124	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL7	P18124	97	142	127	127	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14148
RPL7	P18124	97	142	139	139	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
RPS2	P15880	125	183	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
RPS2	P15880	89	125	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
RPS2	P15880	59	89	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
RPS2	P15880	125	183	102	165	Domain	Note=S5 DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00268
RPS2	P15880	89	125	102	165	Domain	Note=S5 DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00268
RLBP1	P12271	4	47	2	317	Chain	ID=PRO_0000079330;Note=Retinaldehyde-binding protein 1
RLBP1	P12271	4	47	27	29	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY5
RLBP1	P12271	4	47	33	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY5
RLBP1	P12271	4	47	41	43	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY5
RLBP1	P12271	4	47	44	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY5
ROBO2	Q9HCK4	1253	1311	22	1378	Chain	ID=PRO_0000031036;Note=Roundabout homolog 2
ROBO2	Q9HCK4	1253	1311	881	1378	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROBO2	Q9HCK4	1253	1311	1186	1378	Alternative sequence	ID=VSP_010647;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RIN3	Q8TB24	177	675	1	985	Chain	ID=PRO_0000191322;Note=Ras and Rab interactor 3
RIN3	Q8TB24	778	822	1	985	Chain	ID=PRO_0000191322;Note=Ras and Rab interactor 3
RIN3	Q8TB24	778	822	703	846	Domain	Note=VPS9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00550
RIN3	Q8TB24	177	675	587	732	Region	Note=Interaction with RAB5B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12972505;Dbxref=PMID:12972505
RIN3	Q8TB24	177	675	248	514	Compositional bias	Note=Pro-rich
RIN3	Q8TB24	177	675	215	215	Natural variant	ID=VAR_059960;Note=H->L;Dbxref=dbSNP:rs3829947
RIN3	Q8TB24	177	675	215	215	Natural variant	ID=VAR_046646;Note=H->P;Dbxref=dbSNP:rs3829947
RIN3	Q8TB24	177	675	215	215	Natural variant	ID=VAR_059961;Note=H->R;Dbxref=dbSNP:rs3829947
RIN3	Q8TB24	177	675	425	425	Natural variant	ID=VAR_052946;Note=T->I;Dbxref=dbSNP:rs3742717
RIN3	Q8TB24	177	675	425	425	Natural variant	ID=VAR_046647;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3742717,PMID:14702039
RIN3	Q8TB24	177	675	613	613	Natural variant	ID=VAR_046648;Note=G->A;Dbxref=dbSNP:rs12434929
RPS21	P63220	38	62	1	83	Chain	ID=PRO_0000194730;Note=40S ribosomal protein S21
RPS21	P63220	38	62	41	41	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
RPL7A	P62424	41	91	1	266	Chain	ID=PRO_0000136747;Note=60S ribosomal protein L7a
RPL7A	P62424	91	138	1	266	Chain	ID=PRO_0000136747;Note=60S ribosomal protein L7a
RPL7A	P62424	91	138	97	97	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL7A	P62424	41	91	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL7A	P62424	91	138	97	97	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL7A	P62424	91	138	125	125	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RARRES2	Q99969	93	125	21	157	Chain	ID=PRO_0000022529;Note=Retinoic acid receptor responder protein 2
RARRES2	Q99969	58	93	21	157	Chain	ID=PRO_0000022529;Note=Retinoic acid receptor responder protein 2
RARRES2	Q99969	93	125	21	157	Chain	ID=PRO_0000022529;Note=Retinoic acid receptor responder protein 2
RARRES2	Q99969	58	93	21	157	Chain	ID=PRO_0000022529;Note=Retinoic acid receptor responder protein 2
RARRES2	Q99969	93	125	21	157	Chain	ID=PRO_0000022529;Note=Retinoic acid receptor responder protein 2
RARRES2	Q99969	58	93	21	157	Chain	ID=PRO_0000022529;Note=Retinoic acid receptor responder protein 2
RARRES2	Q99969	58	93	77	87	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
RARRES2	Q99969	58	93	77	87	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
RARRES2	Q99969	58	93	77	87	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
RARRES2	Q99969	93	125	98	117	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
RARRES2	Q99969	93	125	98	117	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
RARRES2	Q99969	93	125	98	117	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
RARRES2	Q99969	93	125	101	135	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
RARRES2	Q99969	93	125	101	135	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
RARRES2	Q99969	93	125	101	135	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAPSN	Q13702	304	322	2	412	Chain	ID=PRO_0000167591;Note=43 kDa receptor-associated protein of the synapse
RAPSN	Q13702	263	304	2	412	Chain	ID=PRO_0000167591;Note=43 kDa receptor-associated protein of the synapse
RAPSN	Q13702	177	230	2	412	Chain	ID=PRO_0000167591;Note=43 kDa receptor-associated protein of the synapse
RAPSN	Q13702	177	230	163	196	Repeat	Note=TPR 4
RAPSN	Q13702	177	230	206	239	Repeat	Note=TPR 5
RAPSN	Q13702	263	304	246	279	Repeat	Note=TPR 6
RAPSN	Q13702	304	322	286	319	Repeat	Note=TPR 7
RAPSN	Q13702	263	304	286	319	Repeat	Note=TPR 7
RAPSN	Q13702	177	230	196	196	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RAPSN	Q13702	304	322	264	322	Alternative sequence	ID=VSP_005533;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RAPSN	Q13702	263	304	264	322	Alternative sequence	ID=VSP_005533;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RAPSN	Q13702	177	230	189	189	Natural variant	ID=VAR_043902;Note=In FADS. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18252226;Dbxref=dbSNP:rs121909257,PMID:18252226
RAPSN	Q13702	263	304	283	283	Natural variant	ID=VAR_043903;Note=In CMS11%3B reduced coclustering with acetylcholine receptor. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16931511;Dbxref=dbSNP:rs104894293,PMID:16931511
RAPSN	Q13702	177	230	205	205	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBM22	Q9NW64	36	46	2	420	Chain	ID=PRO_0000250546;Note=Pre-mRNA-splicing factor RBM22
RBM22	Q9NW64	18	36	2	420	Chain	ID=PRO_0000250546;Note=Pre-mRNA-splicing factor RBM22
RBM22	Q9NW64	36	46	43	91	Alternative sequence	ID=VSP_036832;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBMX	P38159	129	180	1	391	Chain	ID=PRO_0000081854;Note=RNA-binding motif protein%2C X chromosome
RBMX	P38159	129	180	2	391	Chain	ID=PRO_0000304582;Note=RNA-binding motif protein%2C X chromosome%2C N-terminally processed
RBMX	P38159	129	180	144	144	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WV02
RBMX	P38159	129	180	164	164	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WV02
RBMX	P38159	129	180	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBMX	P38159	129	180	172	172	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WV02
RBMX	P38159	129	180	174	174	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBMX	P38159	129	180	73	196	Alternative sequence	ID=VSP_043650;Note=In isoform 3. SLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDSYGGPPRR->LLYHVEEIVMEVHLEGNRCPLVEMFICPQEMMGILLKTAIQAEITQVLVILEIMHHHHEIILTVIMVIPVHVMTIHQEDIAIEMDMVVIVTIQIIQVEVPTEIHMRVMVGDFAHYGRGVLIDSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAD23A	P54725	271	326	1	363	Chain	ID=PRO_0000114904;Note=UV excision repair protein RAD23 homolog A
RAD23A	P54725	271	326	318	358	Domain	Note=UBA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
RAD23A	P54725	271	326	319	363	Region	Note=HIV-1 vpr binding
RAD23A	P54725	271	326	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
RAD23A	P54725	271	326	272	326	Alternative sequence	ID=VSP_047565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RAD23A	P54725	271	326	267	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OQY
RAD23A	P54725	271	326	298	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OQY
RAD23A	P54725	271	326	318	320	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OQY
RAD23A	P54725	271	326	321	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DV0
RAD23A	P54725	271	326	325	331	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DV0
ARHGAP30	Q7Z6I6	339	473	1	1101	Chain	ID=PRO_0000280478;Note=Rho GTPase-activating protein 30
ARHGAP30	Q7Z6I6	339	473	244	1101	Alternative sequence	ID=VSP_023734;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ARHGAP39	Q9C0H5	27	170	2	1083	Chain	ID=PRO_0000076092;Note=Rho GTPase-activating protein 39
ARHGAP39	Q9C0H5	27	170	25	58	Domain	Note=WW 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
ARHGAP39	Q9C0H5	27	170	63	97	Domain	Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
ARHGAP39	Q9C0H5	27	170	169	169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARHGAP44	Q17R89	646	772	1	818	Chain	ID=PRO_0000280480;Note=Rho GTPase-activating protein 44
ARHGAP44	Q17R89	646	772	731	818	Region	Note=Interaction with BST2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19273615;Dbxref=PMID:19273615
ARHGAP44	Q17R89	646	772	674	674	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHPN2	Q8IUC4	499	548	1	686	Chain	ID=PRO_0000218898;Note=Rhophilin-2
RHPN2	Q8IUC4	368	408	1	686	Chain	ID=PRO_0000218898;Note=Rhophilin-2
RHPN2	Q8IUC4	62	104	1	686	Chain	ID=PRO_0000218898;Note=Rhophilin-2
RHPN2	Q8IUC4	62	104	26	100	Domain	Note=REM-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01207
RHPN2	Q8IUC4	368	408	111	460	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
RHPN2	Q8IUC4	499	548	515	593	Domain	Note=PDZ
RHPN2	Q8IUC4	62	104	46	66	Region	Note=Interaction with Rho
RHPN2	Q8IUC4	62	104	1	151	Alternative sequence	ID=VSP_055548;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RHPN2	Q8IUC4	62	104	70	70	Natural variant	ID=VAR_061996;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12221077;Dbxref=dbSNP:rs28626308,PMID:12221077
RHPN2	Q8IUC4	499	548	518	518	Mutagenesis	Note=Does not induce actin disassembly but still interacts with RhoA%3B when associated with A-526 and A-527. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12221077;Dbxref=PMID:12221077
RHPN2	Q8IUC4	499	548	526	527	Mutagenesis	Note=Does not induce actin disassembly but still interacts with RhoA%3B when associated with A-518. LG->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12221077;Dbxref=PMID:12221077
RHPN2	Q8IUC4	368	408	391	391	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHPN2	Q8IUC4	368	408	392	392	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHPN2	Q8IUC4	499	548	504	504	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHPN2	Q8IUC4	499	548	513	513	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHPN2	Q8IUC4	499	548	515	519	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSV
RHPN2	Q8IUC4	499	548	522	524	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSV
RHPN2	Q8IUC4	499	548	528	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSV
RHPN2	Q8IUC4	499	548	537	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSV
RHPN2	Q8IUC4	499	548	546	549	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VSV
RICTOR	Q6R327	406	433	1	1708	Chain	ID=PRO_0000308179;Note=Rapamycin-insensitive companion of mTOR
RICTOR	Q6R327	406	433	1	789	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
RICTOR	Q6R327	406	433	258	1708	Alternative sequence	ID=VSP_038363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
RPL31	P62899	36	77	1	125	Chain	ID=PRO_0000153763;Note=60S ribosomal protein L31
RPL31	P62899	36	77	1	125	Chain	ID=PRO_0000153763;Note=60S ribosomal protein L31
RPL31	P62899	36	77	55	55	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	55	55	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	70	70	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	70	70	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL38	P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
RPL38	P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
RPL38	P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
RPL10A	P62906	27	53	2	217	Chain	ID=PRO_0000125818;Note=60S ribosomal protein L10a
RPL22	P35268	4	39	2	128	Chain	ID=PRO_0000215501;Note=60S ribosomal protein L22
RPS16	P62249	82	98	2	146	Chain	ID=PRO_0000111479;Note=40S ribosomal protein S16
RPS16	P62249	16	50	2	146	Chain	ID=PRO_0000111479;Note=40S ribosomal protein S16
RPL23	P62829	75	113	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	32	75	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	75	113	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	32	75	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	4	32	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	4	32	17	17	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
RPL23	P62829	32	75	38	38	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
RPL23	P62829	32	75	38	38	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
RPL23	P62829	75	113	77	77	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL23	P62829	75	113	77	77	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL24	P83731	27	64	1	157	Chain	ID=PRO_0000136867;Note=60S ribosomal protein L24
RPL24	P83731	27	64	27	27	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL24	P83731	27	64	27	27	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL24	P83731	27	64	35	35	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RIPK1	Q13546	107	153	1	671	Chain	ID=PRO_0000086606;Note=Receptor-interacting serine/threonine-protein kinase 1
RIPK1	Q13546	229	279	1	671	Chain	ID=PRO_0000086606;Note=Receptor-interacting serine/threonine-protein kinase 1
RIPK1	Q13546	107	153	1	671	Chain	ID=PRO_0000086606;Note=Receptor-interacting serine/threonine-protein kinase 1
RIPK1	Q13546	229	279	1	671	Chain	ID=PRO_0000086606;Note=Receptor-interacting serine/threonine-protein kinase 1
RIPK1	Q13546	107	153	17	289	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RIPK1	Q13546	229	279	17	289	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RIPK1	Q13546	107	153	17	289	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RIPK1	Q13546	229	279	17	289	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RIPK1	Q13546	107	153	138	138	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
RIPK1	Q13546	107	153	138	138	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
RIPK1	Q13546	107	153	108	153	Alternative sequence	ID=VSP_037690;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RIPK1	Q13546	107	153	108	153	Alternative sequence	ID=VSP_037690;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RIPK1	Q13546	229	279	234	234	Natural variant	ID=VAR_021109;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17548383
RIPK1	Q13546	229	279	234	234	Natural variant	ID=VAR_021109;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs17548383
RIPK1	Q13546	229	279	258	258	Sequence conflict	Note=R->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
RIPK1	Q13546	229	279	258	258	Sequence conflict	Note=R->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
RIPK1	Q13546	107	153	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	112	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	112	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	141	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	141	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	152	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	107	153	152	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	228	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C4D
RIPK1	Q13546	229	279	228	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C4D
RIPK1	Q13546	229	279	234	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	234	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	249	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	249	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	252	255	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C3E
RIPK1	Q13546	229	279	252	255	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6C3E
RIPK1	Q13546	229	279	258	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	258	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	272	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	272	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	278	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
RIPK1	Q13546	229	279	278	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ITJ
PARK7	Q99497	107	136	126	126	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20304780;Dbxref=PMID:20304780
PARK7	Q99497	107	136	126	126	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20304780;Dbxref=PMID:20304780
PARK7	Q99497	107	136	126	126	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20304780;Dbxref=PMID:20304780
PARK7	Q99497	107	136	126	126	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:20304780;Dbxref=PMID:20304780
PARK7	Q99497	64	84	67	67	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PARK7	Q99497	64	84	67	67	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PARK7	Q99497	64	84	67	67	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PARK7	Q99497	64	84	67	67	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PARK7	Q99497	30	64	46	46	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	46	46	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	46	46	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	46	46	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	53	53	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	53	53	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	53	53	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	30	64	53	53	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23847046;Dbxref=PMID:23847046
PARK7	Q99497	107	136	130	130	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15976810;Dbxref=PMID:15976810
PARK7	Q99497	107	136	130	130	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15976810;Dbxref=PMID:15976810
PARK7	Q99497	107	136	130	130	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15976810;Dbxref=PMID:15976810
PARK7	Q99497	107	136	130	130	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15976810;Dbxref=PMID:15976810
PARK7	Q99497	30	64	39	39	Natural variant	ID=VAR_072589;Note=Probable disease-associated mutation found in early-onset Parkinson disease with digenic inheritance%3B the patient also carries PINK1 mutation L-399. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16632486;Dbxref=dbSNP:rs137853051,PMID:16632486
PARK7	Q99497	30	64	39	39	Natural variant	ID=VAR_072589;Note=Probable disease-associated mutation found in early-onset Parkinson disease with digenic inheritance%3B the patient also carries PINK1 mutation L-399. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16632486;Dbxref=dbSNP:rs137853051,PMID:16632486
PARK7	Q99497	30	64	39	39	Natural variant	ID=VAR_072589;Note=Probable disease-associated mutation found in early-onset Parkinson disease with digenic inheritance%3B the patient also carries PINK1 mutation L-399. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16632486;Dbxref=dbSNP:rs137853051,PMID:16632486
PARK7	Q99497	30	64	39	39	Natural variant	ID=VAR_072589;Note=Probable disease-associated mutation found in early-onset Parkinson disease with digenic inheritance%3B the patient also carries PINK1 mutation L-399. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16632486;Dbxref=dbSNP:rs137853051,PMID:16632486
PARK7	Q99497	30	64	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	64	84	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	30	64	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	64	84	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	30	64	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	64	84	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	30	64	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	64	84	64	64	Natural variant	ID=VAR_020493;Note=In PARK7%3B no apparent effect on protein stability%3B impaired mitochondrial morphology. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14607841,ECO:0000269|PubMed:15365989,ECO:0000269|PubMed:20186336;Dbxref=dbSNP:rs74315353,PMID:14607841,PMID:15365989,PMID:20186336
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduced localization in lipid rafts%3B when associated with A-106. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduced localization in lipid rafts%3B when associated with A-106. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduced localization in lipid rafts%3B when associated with A-106. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduced localization in lipid rafts%3B when associated with A-106. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduces protein stability. No effect on oxidation. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduces protein stability. No effect on oxidation. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduces protein stability. No effect on oxidation. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=Reduces protein stability. No effect on oxidation. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046,ECO:0000269|PubMed:25416785;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046,PMID:25416785
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046,ECO:0000269|PubMed:25416785;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046,PMID:25416785
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046,ECO:0000269|PubMed:25416785;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046,PMID:25416785
PARK7	Q99497	30	64	46	46	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:23847046,ECO:0000269|PubMed:25416785;Dbxref=PMID:15181200,PMID:15502874,PMID:18711745,PMID:23847046,PMID:25416785
PARK7	Q99497	30	64	51	51	Mutagenesis	Note=Disrupts dimer formation and strongly reduces ability to eliminate hydrogen peroxide. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14749723;Dbxref=PMID:14749723
PARK7	Q99497	30	64	51	51	Mutagenesis	Note=Disrupts dimer formation and strongly reduces ability to eliminate hydrogen peroxide. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14749723;Dbxref=PMID:14749723
PARK7	Q99497	30	64	51	51	Mutagenesis	Note=Disrupts dimer formation and strongly reduces ability to eliminate hydrogen peroxide. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14749723;Dbxref=PMID:14749723
PARK7	Q99497	30	64	51	51	Mutagenesis	Note=Disrupts dimer formation and strongly reduces ability to eliminate hydrogen peroxide. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14749723;Dbxref=PMID:14749723
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=Strongly reduces chaperone activity and ability to eliminate hydrogen peroxide. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=Strongly reduces chaperone activity and ability to eliminate hydrogen peroxide. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=Strongly reduces chaperone activity and ability to eliminate hydrogen peroxide. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=Strongly reduces chaperone activity and ability to eliminate hydrogen peroxide. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:25416785;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745,PMID:25416785
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:25416785;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745,PMID:25416785
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:25416785;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745,PMID:25416785
PARK7	Q99497	30	64	53	53	Mutagenesis	Note=No effect on mitochondrial translocation neither on deglycase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14749723,ECO:0000269|PubMed:15181200,ECO:0000269|PubMed:15502874,ECO:0000269|PubMed:18711745,ECO:0000269|PubMed:25416785;Dbxref=PMID:14749723,PMID:15181200,PMID:15502874,PMID:18711745,PMID:25416785
PARK7	Q99497	107	136	126	126	Mutagenesis	Note=Strongly decreases enzymatic activity. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20304780,ECO:0000269|PubMed:22523093;Dbxref=PMID:20304780,PMID:22523093
PARK7	Q99497	107	136	126	126	Mutagenesis	Note=Strongly decreases enzymatic activity. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20304780,ECO:0000269|PubMed:22523093;Dbxref=PMID:20304780,PMID:22523093
PARK7	Q99497	107	136	126	126	Mutagenesis	Note=Strongly decreases enzymatic activity. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20304780,ECO:0000269|PubMed:22523093;Dbxref=PMID:20304780,PMID:22523093
PARK7	Q99497	107	136	126	126	Mutagenesis	Note=Strongly decreases enzymatic activity. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20304780,ECO:0000269|PubMed:22523093;Dbxref=PMID:20304780,PMID:22523093
PARK7	Q99497	107	136	130	130	Mutagenesis	Note=Partially compensates for loss of stability%3B when associated with P-166. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12851414;Dbxref=PMID:12851414
PARK7	Q99497	107	136	130	130	Mutagenesis	Note=Partially compensates for loss of stability%3B when associated with P-166. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12851414;Dbxref=PMID:12851414
PARK7	Q99497	107	136	130	130	Mutagenesis	Note=Partially compensates for loss of stability%3B when associated with P-166. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12851414;Dbxref=PMID:12851414
PARK7	Q99497	107	136	130	130	Mutagenesis	Note=Partially compensates for loss of stability%3B when associated with P-166. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12851414;Dbxref=PMID:12851414
PARK7	Q99497	107	136	119	119	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARK7	Q99497	107	136	119	119	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARK7	Q99497	107	136	119	119	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARK7	Q99497	107	136	119	119	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARK7	Q99497	30	64	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	38	41	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PDW
PARK7	Q99497	30	64	38	41	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PDW
PARK7	Q99497	30	64	38	41	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PDW
PARK7	Q99497	30	64	38	41	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PDW
PARK7	Q99497	30	64	47	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0M
PARK7	Q99497	30	64	47	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0M
PARK7	Q99497	30	64	47	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0M
PARK7	Q99497	30	64	47	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N0M
PARK7	Q99497	30	64	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OR3
PARK7	Q99497	30	64	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OR3
PARK7	Q99497	30	64	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OR3
PARK7	Q99497	30	64	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OR3
PARK7	Q99497	30	64	55	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	55	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	55	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	55	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	58	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	58	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	58	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	30	64	58	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	76	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	76	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	76	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	64	84	76	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	130	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	130	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	130	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	130	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PARK7	Q99497	107	136	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RK3
PAX2	Q02962	205	228	1	417	Chain	ID=PRO_0000050175;Note=Paired box protein Pax-2
PAX2	Q02962	329	363	1	417	Chain	ID=PRO_0000050175;Note=Paired box protein Pax-2
PAX2	Q02962	205	228	226	226	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PAX2	Q02962	205	228	206	228	Alternative sequence	ID=VSP_002345;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1378753,ECO:0000303|PubMed:7819127;Dbxref=PMID:1378753,PMID:7819127
PAX2	Q02962	329	363	329	329	Natural variant	ID=VAR_071947;Note=In PAPRS. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676634;Dbxref=PMID:24676634
PAX2	Q02962	329	363	334	334	Natural variant	ID=VAR_012443;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11180607,ECO:0000269|PubMed:22213154;Dbxref=dbSNP:rs78738655,PMID:11180607,PMID:22213154
PDK3	Q15120	284	321	131	362	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK3	Q15120	321	359	131	362	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK3	Q15120	284	321	306	307	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15861126;Dbxref=PMID:15861126
PDK3	Q15120	321	359	323	328	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15861126;Dbxref=PMID:15861126
PDK3	Q15120	284	321	287	287	Binding site	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15861126;Dbxref=PMID:15861126
PDK3	Q15120	321	359	334	334	Natural variant	ID=VAR_070083;Note=Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23297365;Dbxref=PMID:23297365
PDK3	Q15120	284	321	278	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	284	321	294	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	284	321	298	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	284	321	303	305	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	321	359	323	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8P
PDK3	Q15120	321	359	327	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	321	359	341	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	321	359	348	350	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDK3	Q15120	321	359	351	360	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8O
PDS5B	Q9NTI5	235	282	1	1447	Chain	ID=PRO_0000287424;Note=Sister chromatid cohesion protein PDS5 homolog B
PDS5B	Q9NTI5	452	489	1	1447	Chain	ID=PRO_0000287424;Note=Sister chromatid cohesion protein PDS5 homolog B
PDS5B	Q9NTI5	749	802	1	1447	Chain	ID=PRO_0000287424;Note=Sister chromatid cohesion protein PDS5 homolog B
PDS5B	Q9NTI5	1103	1124	1	1447	Chain	ID=PRO_0000287424;Note=Sister chromatid cohesion protein PDS5 homolog B
PDS5B	Q9NTI5	1355	1390	1	1447	Chain	ID=PRO_0000287424;Note=Sister chromatid cohesion protein PDS5 homolog B
PDS5B	Q9NTI5	1355	1390	1372	1384	DNA binding	Note=A.T hook 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDS5B	Q9NTI5	1355	1390	1358	1358	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18691976,PMID:19367720,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PDS5B	Q9NTI5	1355	1390	1366	1366	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VA53
PDS5B	Q9NTI5	1355	1390	1367	1367	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
PDS5B	Q9NTI5	1355	1390	1369	1369	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VA53
PDS5B	Q9NTI5	1355	1390	1370	1370	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:19690332,PMID:23186163
PDS5B	Q9NTI5	1355	1390	1381	1381	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
PDS5B	Q9NTI5	1355	1390	1383	1383	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
PDS5B	Q9NTI5	235	282	1	1230	Alternative sequence	ID=VSP_052396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDS5B	Q9NTI5	452	489	1	1230	Alternative sequence	ID=VSP_052396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDS5B	Q9NTI5	749	802	1	1230	Alternative sequence	ID=VSP_052396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDS5B	Q9NTI5	1103	1124	1	1230	Alternative sequence	ID=VSP_052396;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDS5B	Q9NTI5	235	282	123	1447	Alternative sequence	ID=VSP_052398;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	452	489	123	1447	Alternative sequence	ID=VSP_052398;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	749	802	123	1447	Alternative sequence	ID=VSP_052398;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	1103	1124	123	1447	Alternative sequence	ID=VSP_052398;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	1355	1390	123	1447	Alternative sequence	ID=VSP_052398;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	749	802	530	1447	Alternative sequence	ID=VSP_052400;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	1103	1124	530	1447	Alternative sequence	ID=VSP_052400;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	1355	1390	530	1447	Alternative sequence	ID=VSP_052400;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDS5B	Q9NTI5	1355	1390	1356	1447	Alternative sequence	ID=VSP_052401;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDS5B	Q9NTI5	235	282	256	256	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDS5B	Q9NTI5	1103	1124	1115	1115	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDS5B	Q9NTI5	1355	1390	1359	1359	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDS5B	Q9NTI5	235	282	226	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	235	282	252	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	235	282	255	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	235	282	267	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	235	282	271	273	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	235	282	274	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	452	489	449	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	452	489	470	481	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	452	489	486	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	749	802	740	754	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	749	802	761	763	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	749	802	764	776	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	749	802	778	781	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	749	802	782	791	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDS5B	Q9NTI5	749	802	794	797	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HDT
PDXK	O00764	82	110	1	312	Chain	ID=PRO_0000213335;Note=Pyridoxal kinase
PDXK	O00764	82	110	83	110	Alternative sequence	ID=VSP_004653;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDXK	O00764	82	110	78	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YXT
PDXK	O00764	82	110	88	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YXT
PDXK	O00764	82	110	109	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YXT
PDZD11	Q5EBL8	57	76	1	140	Chain	ID=PRO_0000058273;Note=PDZ domain-containing protein 11
PDZD11	Q5EBL8	57	76	1	140	Chain	ID=PRO_0000058273;Note=PDZ domain-containing protein 11
PDZD11	Q5EBL8	57	76	47	129	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PDZD11	Q5EBL8	57	76	47	129	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
RAB2A	P61019	158	181	2	212	Chain	ID=PRO_0000121066;Note=Ras-related protein Rab-2A
RAB2A	P61019	158	181	156	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z0A
RAC1	P63000	75	96	1	189	Chain	ID=PRO_0000042036;Note=Ras-related C3 botulinum toxin substrate 1
RAC1	P63000	75	96	75	75	Alternative sequence	ID=VSP_005710;Note=In isoform B. T->TVGETYGKDITSRGKDKPIA;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10597294,ECO:0000303|PubMed:11062023,ECO:0000303|Ref.5;Dbxref=PMID:10597294,PMID:11062023
RAC1	P63000	75	96	93	93	Natural variant	ID=VAR_014545;Note=V->G;Dbxref=dbSNP:rs5826
RAC1	P63000	75	96	93	93	Natural variant	ID=VAR_014544;Note=V->I;Dbxref=dbSNP:rs5825
RAC1	P63000	75	96	76	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MH1
RAC1	P63000	75	96	87	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MH1
PTGES2	Q9H7Z7	229	295	1	377	Chain	ID=PRO_0000013127;Note=Prostaglandin E synthase 2
PTGES2	Q9H7Z7	179	228	1	377	Chain	ID=PRO_0000013127;Note=Prostaglandin E synthase 2
PTGES2	Q9H7Z7	229	295	88	377	Chain	ID=PRO_0000013128;Note=Prostaglandin E synthase 2 truncated form;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTGES2	Q9H7Z7	179	228	88	377	Chain	ID=PRO_0000013128;Note=Prostaglandin E synthase 2 truncated form;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTGES2	Q9H7Z7	229	295	75	377	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTGES2	Q9H7Z7	179	228	75	377	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTGES2	Q9H7Z7	179	228	90	193	Domain	Note=Glutaredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00686
PTGES2	Q9H7Z7	229	295	263	377	Domain	Note=GST C-terminal
RDX	P35241	417	448	1	583	Chain	ID=PRO_0000219421;Note=Radixin
RDX	P35241	32	64	1	583	Chain	ID=PRO_0000219421;Note=Radixin
RDX	P35241	32	64	5	295	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
RDX	P35241	32	64	60	63	Region	Note=Phosphatidylinositol binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
RDX	P35241	417	448	311	522	Compositional bias	Note=Glu-rich
RDX	P35241	32	64	1	347	Alternative sequence	ID=VSP_045315;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17226784;Dbxref=PMID:17226784
RDX	P35241	32	64	1	156	Alternative sequence	ID=VSP_047276;Note=In isoform 4. MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQR->MLSWNLPFSPIQLANNFLTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RDX	P35241	32	64	33	64	Alternative sequence	ID=VSP_045316;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17226784;Dbxref=PMID:17226784
RDX	P35241	417	448	168	539	Alternative sequence	ID=VSP_045317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17226784;Dbxref=PMID:17226784
RDX	P35241	417	448	435	435	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RABGGTB	P53611	37	103	2	331	Chain	ID=PRO_0000119772;Note=Geranylgeranyl transferase type-2 subunit beta
RABGGTB	P53611	193	235	2	331	Chain	ID=PRO_0000119772;Note=Geranylgeranyl transferase type-2 subunit beta
RABGGTB	P53611	235	285	2	331	Chain	ID=PRO_0000119772;Note=Geranylgeranyl transferase type-2 subunit beta
RABGGTB	P53611	37	103	20	61	Repeat	Note=PFTB 1
RABGGTB	P53611	37	103	68	109	Repeat	Note=PFTB 2
RABGGTB	P53611	193	235	164	205	Repeat	Note=PFTB 4
RABGGTB	P53611	193	235	212	253	Repeat	Note=PFTB 5
RABGGTB	P53611	235	285	212	253	Repeat	Note=PFTB 5
RABGGTB	P53611	235	285	260	302	Repeat	Note=PFTB 6
RABGGTB	P53611	193	235	232	244	Region	Note=Geranylgeranyl diphosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGGTB	P53611	235	285	232	244	Region	Note=Geranylgeranyl diphosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGGTB	P53611	235	285	238	238	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGGTB	P53611	235	285	238	238	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGGTB	P53611	235	285	240	240	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGGTB	P53611	235	285	240	240	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGGTB	P53611	193	235	211	211	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAH	P00439	304	323	1	452	Chain	ID=PRO_0000205548;Note=Phenylalanine-4-hydroxylase
PAH	P00439	304	323	304	304	Natural variant	ID=VAR_000991;Note=In PKU. Q->R;Dbxref=dbSNP:rs199475592
PAH	P00439	304	323	306	306	Natural variant	ID=VAR_000992;Note=In non-PKU HPA%3B haplotype 4. I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1358789,ECO:0000269|PubMed:23792259;Dbxref=dbSNP:rs62642934,PMID:1358789,PMID:23792259
PAH	P00439	304	323	309	309	Natural variant	ID=VAR_000993;Note=In PKU%3B haplotype 7. A->D;Dbxref=dbSNP:rs62642935
PAH	P00439	304	323	309	309	Natural variant	ID=VAR_000994;Note=In PKU. A->V;Dbxref=dbSNP:rs62642935
PAH	P00439	304	323	310	310	Natural variant	ID=VAR_000995;Note=In PKU%3B haplotype 7. S->F;Dbxref=dbSNP:rs62642913
PAH	P00439	304	323	310	310	Natural variant	ID=VAR_068005;Note=In HPA%3B reduction in activity is probably due to a global conformational change in the protein that reduces allostery. S->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12501224,ECO:0000269|PubMed:18538294;Dbxref=dbSNP:rs62642913,PMID:12501224,PMID:18538294
PAH	P00439	304	323	311	311	Natural variant	ID=VAR_000996;Note=In PKU%3B haplotypes 1%2C7%2C10. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2615649,ECO:0000269|PubMed:2840952;Dbxref=dbSNP:rs62642936,PMID:2615649,PMID:2840952
PAH	P00439	304	323	314	314	Natural variant	ID=VAR_000997;Note=In PKU. P->H;Dbxref=dbSNP:rs62642940
PAH	P00439	304	323	314	314	Natural variant	ID=VAR_068006;Note=In HPA%3B does not affect oligomerization%3B reduction in activity is probably due to a global conformational change in the protein that reduces allostery. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12501224,ECO:0000269|PubMed:18538294;Dbxref=dbSNP:rs199475650,PMID:12501224,PMID:18538294
PAH	P00439	304	323	318	318	Natural variant	ID=VAR_011574;Note=In PKU%3B partial loss of activity. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11461196;Dbxref=dbSNP:rs62642918,PMID:11461196
PAH	P00439	304	323	322	322	Natural variant	ID=VAR_000998;Note=In PKU%3B haplotype 12. A->G;Dbxref=dbSNP:rs62514958
PAH	P00439	304	323	322	322	Natural variant	ID=VAR_000999;Note=In PKU%3B haplotype 1. A->T;Dbxref=dbSNP:rs62514957
PAH	P00439	304	323	322	322	Natural variant	ID=VAR_067759;Note=In PKU. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22526846;Dbxref=PMID:22526846
PAH	P00439	304	323	297	310	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J8U
PAH	P00439	304	323	315	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J8U
PARVG	Q9HBI0	214	237	1	331	Chain	ID=PRO_0000121585;Note=Gamma-parvin
PARVG	Q9HBI0	214	237	1	331	Chain	ID=PRO_0000121585;Note=Gamma-parvin
PARVG	Q9HBI0	214	237	210	317	Domain	Note=Calponin-homology (CH) 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
PARVG	Q9HBI0	214	237	210	317	Domain	Note=Calponin-homology (CH) 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
PARVG	Q9HBI0	214	237	71	331	Alternative sequence	ID=VSP_045147;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARVG	Q9HBI0	214	237	71	331	Alternative sequence	ID=VSP_045147;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARVG	Q9HBI0	214	237	188	331	Alternative sequence	ID=VSP_012954;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
PARVG	Q9HBI0	214	237	188	331	Alternative sequence	ID=VSP_012954;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
PASK	Q96RG2	1066	1111	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1024	1066	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	143	200	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1066	1111	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1024	1066	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	143	200	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	880	925	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	838	880	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	143	200	119	190	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
PASK	Q96RG2	143	200	119	190	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
PASK	Q96RG2	1066	1111	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1024	1066	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1066	1111	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1024	1066	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1066	1111	1082	1089	Nucleotide binding	Note=ATP
PASK	Q96RG2	1066	1111	1082	1089	Nucleotide binding	Note=ATP
PASK	Q96RG2	1024	1066	1028	1028	Binding site	Note=ATP
PASK	Q96RG2	1024	1066	1028	1028	Binding site	Note=ATP
PASK	Q96RG2	1066	1111	1111	1111	Alternative sequence	ID=VSP_009302;Note=In isoform 2. Q->QVRAGQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
PASK	Q96RG2	1066	1111	1111	1111	Alternative sequence	ID=VSP_009302;Note=In isoform 2. Q->QVRAGQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
PASK	Q96RG2	838	880	844	844	Natural variant	ID=VAR_040991;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36082918,PMID:17344846
PASK	Q96RG2	1024	1066	1028	1028	Mutagenesis	Note=Loss of autophosphorylating activity. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11459942,ECO:0000269|PubMed:20943661;Dbxref=PMID:11459942,PMID:20943661
PASK	Q96RG2	1024	1066	1028	1028	Mutagenesis	Note=Loss of autophosphorylating activity. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11459942,ECO:0000269|PubMed:20943661;Dbxref=PMID:11459942,PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Induces lower protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Induces lower protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Does not affect protein kinase activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Does not affect protein kinase activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	838	880	850	850	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	880	925	899	899	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1048	1048	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1048	1048	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1062	1062	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1062	1062	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	143	200	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	151	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	151	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	174	176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	174	176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	177	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	177	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	1024	1066	1023	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1023	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1039	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1039	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1044	1046	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1044	1046	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1047	1050	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1047	1050	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1051	1056	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1051	1056	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1067	1072	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1067	1072	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1074	1082	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1074	1082	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1090	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1090	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1102	1121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1102	1121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PARP2	Q9UGN5	15	80	1	583	Chain	ID=PRO_0000211327;Note=Poly [ADP-ribose] polymerase 2
PARP2	Q9UGN5	15	80	1	88	DNA binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
PARP2	Q9UGN5	15	80	35	40	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARP2	Q9UGN5	15	80	37	37	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88554
PARP2	Q9UGN5	15	80	38	38	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88554
PARP2	Q9UGN5	15	80	68	80	Alternative sequence	ID=VSP_004537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10364231;Dbxref=PMID:10364231
PCBP4	P57723	172	197	1	403	Chain	ID=PRO_0000050094;Note=Poly(rC)-binding protein 4
PCBP4	P57723	129	172	1	403	Chain	ID=PRO_0000050094;Note=Poly(rC)-binding protein 4
PCBP4	P57723	172	197	1	403	Chain	ID=PRO_0000050094;Note=Poly(rC)-binding protein 4
PCBP4	P57723	129	172	1	403	Chain	ID=PRO_0000050094;Note=Poly(rC)-binding protein 4
PCBP4	P57723	172	197	1	403	Chain	ID=PRO_0000050094;Note=Poly(rC)-binding protein 4
PCBP4	P57723	129	172	1	403	Chain	ID=PRO_0000050094;Note=Poly(rC)-binding protein 4
PCBP4	P57723	129	172	101	154	Domain	Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PCBP4	P57723	129	172	101	154	Domain	Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PCBP4	P57723	129	172	101	154	Domain	Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PCBP4	P57723	172	197	130	172	Alternative sequence	ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP4	P57723	129	172	130	172	Alternative sequence	ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP4	P57723	172	197	130	172	Alternative sequence	ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP4	P57723	129	172	130	172	Alternative sequence	ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP4	P57723	172	197	130	172	Alternative sequence	ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP4	P57723	129	172	130	172	Alternative sequence	ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCED1A	Q9H1Q7	280	372	1	454	Chain	ID=PRO_0000079446;Note=PC-esterase domain-containing protein 1A
PCED1A	Q9H1Q7	280	372	312	315	Compositional bias	Note=Poly-Pro
PCED1A	Q9H1Q7	280	372	153	454	Alternative sequence	ID=VSP_013918;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCED1A	Q9H1Q7	280	372	264	354	Alternative sequence	ID=VSP_003819;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PGC	P20142	305	338	60	388	Chain	ID=PRO_0000026057;Note=Gastricsin
PGC	P20142	216	255	60	388	Chain	ID=PRO_0000026057;Note=Gastricsin
PGC	P20142	305	338	73	385	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
PGC	P20142	216	255	73	385	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
PGC	P20142	305	338	310	343	Disulfide bond	.
PGC	P20142	305	338	217	388	Alternative sequence	ID=VSP_042312;Note=In isoform 2. QQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA->LVLESSGLGPLLTPSRAAPPSSTLQLPEKPLEQTWNILTPFTKTLPVSNLSRKVTSWAGVGIPVTCLPEAGSGGERRAECGLGVPTTRGPPRSQHHSGA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PGC	P20142	216	255	217	388	Alternative sequence	ID=VSP_042312;Note=In isoform 2. QQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA->LVLESSGLGPLLTPSRAAPPSSTLQLPEKPLEQTWNILTPFTKTLPVSNLSRKVTSWAGVGIPVTCLPEAGSGGERRAECGLGVPTTRGPPRSQHHSGA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PGC	P20142	216	255	219	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	216	255	232	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	216	255	235	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	216	255	246	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	216	255	251	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	305	338	306	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	305	338	310	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	305	338	319	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	305	338	326	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	305	338	332	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PGC	P20142	305	338	336	338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HTR
PER1	O15534	739	820	1	1290	Chain	ID=PRO_0000162627;Note=Period circadian protein homolog 1
PER1	O15534	679	739	1	1290	Chain	ID=PRO_0000162627;Note=Period circadian protein homolog 1
PER1	O15534	92	124	1	1290	Chain	ID=PRO_0000162627;Note=Period circadian protein homolog 1
PER1	O15534	92	124	1	151	Region	Note=Interaction with BTRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222
PER1	O15534	739	820	596	815	Region	Note=Required for phosphorylation by CSNK1E;Ontology_term=ECO:0000250;evidence=ECO:0000250
PER1	O15534	679	739	596	815	Region	Note=Required for phosphorylation by CSNK1E;Ontology_term=ECO:0000250;evidence=ECO:0000250
PER1	O15534	92	124	49	129	Compositional bias	Note=Ser-rich
PER1	O15534	92	124	121	121	Modified residue	Note=Phosphothreonine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255
PER1	O15534	92	124	122	122	Modified residue	Note=Phosphoserine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255
PER1	O15534	679	739	704	704	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
PER1	O15534	739	820	815	815	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
PER1	O15534	679	739	696	696	Natural variant	ID=VAR_036038;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
PER1	O15534	92	124	121	126	Mutagenesis	Note=Strongly decreases interaction with BTRC and FBXW11 and inhibits degradation promoted by CSNK1E. TSGCSS->AAGCSA
PER1	O15534	679	739	714	726	Mutagenesis	Note=No effect on interaction with BTRC and FBXW11. SVVSVTSQCSFSS->AVVAVTAQCAFAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222
PER1	O15534	739	820	794	798	Mutagenesis	Note=Strongly decreases interaction with BTRC and FBXW11. FLSRF->ALSRA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222
RAB13	P51153	138	160	1	200	Chain	ID=PRO_0000121182;Note=Ras-related protein Rab-13
RAB13	P51153	108	138	1	200	Chain	ID=PRO_0000121182;Note=Ras-related protein Rab-13
RAB13	P51153	82	108	1	200	Chain	ID=PRO_0000121182;Note=Ras-related protein Rab-13
RAB13	P51153	108	138	121	124	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB28	P51157	165	191	2	218	Chain	ID=PRO_0000121227;Note=Ras-related protein Rab-28
RAB28	P51157	165	191	166	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HXS
RAB31	Q13636	67	91	1	194	Chain	ID=PRO_0000121232;Note=Ras-related protein Rab-31
RAB31	Q13636	67	91	65	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5
RAB31	Q13636	67	91	72	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5
RAB31	Q13636	67	91	79	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5
RAB31	Q13636	67	91	91	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5
RAB36	O95755	120	141	1	333	Chain	ID=PRO_0000121248;Note=Ras-related protein Rab-36
RAB36	O95755	120	141	130	137	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB36	O95755	120	141	121	142	Alternative sequence	ID=VSP_010143;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PEX16	Q9Y5Y5	256	295	1	336	Chain	ID=PRO_0000058330;Note=Peroxisomal membrane protein PEX16
PEX16	Q9Y5Y5	37	49	1	336	Chain	ID=PRO_0000058330;Note=Peroxisomal membrane protein PEX16
PEX16	Q9Y5Y5	37	49	1	84	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX16	Q9Y5Y5	256	295	132	336	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX16	Q9Y5Y5	256	295	221	336	Region	Note=Interaction with PEX19
PEX16	Q9Y5Y5	256	295	289	289	Natural variant	ID=VAR_069209;Note=In PBD8B. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20647552;Dbxref=PMID:20647552
PEX3	P56589	24	68	1	373	Chain	ID=PRO_0000208737;Note=Peroxisomal biogenesis factor 3
PEX3	P56589	273	313	1	373	Chain	ID=PRO_0000208737;Note=Peroxisomal biogenesis factor 3
PEX3	P56589	24	68	16	36	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX3	P56589	24	68	37	116	Topological domain	Note=Peroxisomal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX3	P56589	273	313	141	373	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX3	P56589	24	68	1	45	Region	Note=Targeting to peroxisomes
PEX3	P56589	24	68	41	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MK4
PEX3	P56589	273	313	274	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MK4
RAB8B	Q92930	82	108	1	204	Chain	ID=PRO_0000121134;Note=Ras-related protein Rab-8B
RAB8B	Q92930	138	160	1	204	Chain	ID=PRO_0000121134;Note=Ras-related protein Rab-8B
RAB8B	Q92930	160	177	1	204	Chain	ID=PRO_0000121134;Note=Ras-related protein Rab-8B
PFKM	P08237	198	212	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	281	312	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	312	354	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	500	551	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	551	606	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	198	212	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	281	312	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	312	354	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	500	551	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	551	606	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	198	212	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	281	312	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	312	354	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	500	551	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	551	606	2	780	Chain	ID=PRO_0000112016;Note=ATP-dependent 6-phosphofructokinase%2C muscle type
PFKM	P08237	198	212	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	281	312	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	312	354	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	198	212	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	281	312	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	312	354	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	198	212	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	281	312	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	312	354	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKM	P08237	198	212	208	210	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	198	212	208	210	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	198	212	208	210	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	281	312	298	301	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	281	312	298	301	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	281	312	298	301	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	500	551	402	780	Region	Note=C-terminal regulatory PFK domain 2
PFKM	P08237	551	606	402	780	Region	Note=C-terminal regulatory PFK domain 2
PFKM	P08237	500	551	402	780	Region	Note=C-terminal regulatory PFK domain 2
PFKM	P08237	551	606	402	780	Region	Note=C-terminal regulatory PFK domain 2
PFKM	P08237	500	551	402	780	Region	Note=C-terminal regulatory PFK domain 2
PFKM	P08237	551	606	402	780	Region	Note=C-terminal regulatory PFK domain 2
PFKM	P08237	500	551	528	532	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	500	551	528	532	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	500	551	528	532	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	551	606	573	575	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	551	606	573	575	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	551	606	573	575	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	198	212	201	201	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	198	212	201	201	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	198	212	201	201	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	281	312	292	292	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	281	312	292	292	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	281	312	292	292	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	551	606	566	566	Binding site	Note=Allosteric activator fructose 2%2C6-bisphosphate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	551	606	566	566	Binding site	Note=Allosteric activator fructose 2%2C6-bisphosphate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	551	606	566	566	Binding site	Note=Allosteric activator fructose 2%2C6-bisphosphate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKM	P08237	500	551	530	530	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
PFKM	P08237	500	551	530	530	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
PFKM	P08237	500	551	530	530	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
PFKM	P08237	281	312	282	312	Alternative sequence	ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567
PFKM	P08237	312	354	282	312	Alternative sequence	ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567
PFKM	P08237	281	312	282	312	Alternative sequence	ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567
PFKM	P08237	312	354	282	312	Alternative sequence	ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567
PFKM	P08237	281	312	282	312	Alternative sequence	ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567
PFKM	P08237	312	354	282	312	Alternative sequence	ID=VSP_004667;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2140567;Dbxref=PMID:2140567
PFKM	P08237	198	212	209	209	Natural variant	ID=VAR_006066;Note=In GSD7%3B loss of activity shown by complementation assays in yeast. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7825568;Dbxref=dbSNP:rs767265360,PMID:7825568
PFKM	P08237	198	212	209	209	Natural variant	ID=VAR_006066;Note=In GSD7%3B loss of activity shown by complementation assays in yeast. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7825568;Dbxref=dbSNP:rs767265360,PMID:7825568
PFKM	P08237	198	212	209	209	Natural variant	ID=VAR_006066;Note=In GSD7%3B loss of activity shown by complementation assays in yeast. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7825568;Dbxref=dbSNP:rs767265360,PMID:7825568
PFKM	P08237	281	312	309	309	Natural variant	ID=VAR_072241;Note=In GSD7%3B Spanish%3B complete loss of enzyme activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24427140;Dbxref=dbSNP:rs1169383137,PMID:24427140
PFKM	P08237	281	312	309	309	Natural variant	ID=VAR_072241;Note=In GSD7%3B Spanish%3B complete loss of enzyme activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24427140;Dbxref=dbSNP:rs1169383137,PMID:24427140
PFKM	P08237	281	312	309	309	Natural variant	ID=VAR_072241;Note=In GSD7%3B Spanish%3B complete loss of enzyme activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24427140;Dbxref=dbSNP:rs1169383137,PMID:24427140
PFKM	P08237	500	551	543	543	Natural variant	ID=VAR_006067;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7513946;Dbxref=dbSNP:rs121918194,PMID:7513946
PFKM	P08237	500	551	543	543	Natural variant	ID=VAR_006067;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7513946;Dbxref=dbSNP:rs121918194,PMID:7513946
PFKM	P08237	500	551	543	543	Natural variant	ID=VAR_006067;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7513946;Dbxref=dbSNP:rs121918194,PMID:7513946
PFKM	P08237	551	606	591	591	Natural variant	ID=VAR_072242;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22133655;Dbxref=PMID:22133655
PFKM	P08237	551	606	591	591	Natural variant	ID=VAR_072242;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22133655;Dbxref=PMID:22133655
PFKM	P08237	551	606	591	591	Natural variant	ID=VAR_072242;Note=In GSD7%3B Italian. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22133655;Dbxref=PMID:22133655
REXO2	Q9Y3B8	177	194	26	237	Chain	ID=PRO_0000020273;Note=Oligoribonuclease%2C mitochondrial
REXO2	Q9Y3B8	177	194	43	207	Domain	Note=Exonuclease
OSBP	P22059	393	437	2	807	Chain	ID=PRO_0000100364;Note=Oxysterol-binding protein 1
OSBP	P22059	393	437	406	457	Region	Note=Sterol binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
OSBPL2	Q9H1P3	261	290	1	480	Chain	ID=PRO_0000100369;Note=Oxysterol-binding protein-related protein 2
OSBPL2	Q9H1P3	332	375	1	480	Chain	ID=PRO_0000100369;Note=Oxysterol-binding protein-related protein 2
PATZ1	Q9HBE1	502	548	1	687	Chain	ID=PRO_0000047504;Note=POZ-%2C AT hook-%2C and zinc finger-containing protein 1
PATZ1	Q9HBE1	502	548	495	518	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PATZ1	Q9HBE1	502	548	446	537	Alternative sequence	ID=VSP_008802;Note=In isoform 4. TCNASFATRDRLRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGA->VWVGSSSGLPPLEPLPSDLPSWDFAQPALWRSSHSVPDTAFSLSLKKSFPALENLGPAHSSNTLFCPAPPGYLRQGWTTPEGSRAFTQWPVG;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10713105,ECO:0000303|PubMed:10949935,ECO:0000303|PubMed:15489334;Dbxref=PMID:10713105,PMID:10949935,PMID:15489334
PATZ1	Q9HBE1	502	548	503	548	Alternative sequence	ID=VSP_008801;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10949935,ECO:0000303|PubMed:15461802,ECO:0000303|Ref.4;Dbxref=PMID:10949935,PMID:15461802
PATZ1	Q9HBE1	502	548	504	537	Alternative sequence	ID=VSP_008799;Note=In isoform 2. FSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGA->LQAPGAHPEWGSSVPLRQDLWQQRRPEMLTSGSD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10949935;Dbxref=PMID:10949935
PATZ1	Q9HBE1	502	548	538	687	Alternative sequence	ID=VSP_008800;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10713105,ECO:0000303|PubMed:10949935,ECO:0000303|PubMed:15489334;Dbxref=PMID:10713105,PMID:10949935,PMID:15489334
PARL	Q9H300	276	310	53	379	Chain	ID=PRO_0000027386;Note=Presenilins-associated rhomboid-like protein%2C mitochondrial
PARL	Q9H300	202	252	53	379	Chain	ID=PRO_0000027386;Note=Presenilins-associated rhomboid-like protein%2C mitochondrial
PARL	Q9H300	170	202	53	379	Chain	ID=PRO_0000027386;Note=Presenilins-associated rhomboid-like protein%2C mitochondrial
PARL	Q9H300	107	154	53	379	Chain	ID=PRO_0000027386;Note=Presenilins-associated rhomboid-like protein%2C mitochondrial
PARL	Q9H300	107	154	102	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	107	154	122	167	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	170	202	168	187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	202	252	188	207	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	170	202	188	207	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	202	252	208	230	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	202	252	231	244	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	202	252	245	262	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	276	310	273	289	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	276	310	290	295	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	276	310	296	318	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARL	Q9H300	276	310	277	277	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
PARL	Q9H300	202	252	203	253	Alternative sequence	ID=VSP_013310;Note=In isoform 2. KVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PARL	Q9H300	107	154	137	137	Natural variant	ID=VAR_029801;Note=A->G;Dbxref=dbSNP:rs4912470
PBDC1	Q9BVG4	32	52	1	233	Chain	ID=PRO_0000254105;Note=Protein PBDC1
PARP3	Q9Y6F1	337	366	1	533	Chain	ID=PRO_0000211329;Note=Poly [ADP-ribose] polymerase 3
PARP3	Q9Y6F1	337	366	1	533	Chain	ID=PRO_0000211329;Note=Poly [ADP-ribose] polymerase 3
PARP3	Q9Y6F1	337	366	313	533	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP3	Q9Y6F1	337	366	313	533	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP3	Q9Y6F1	337	366	336	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV2
PARP3	Q9Y6F1	337	366	336	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV2
PARP3	Q9Y6F1	337	366	349	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV2
PARP3	Q9Y6F1	337	366	349	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV2
PARP3	Q9Y6F1	337	366	354	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV2
PARP3	Q9Y6F1	337	366	354	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV2
PARP3	Q9Y6F1	337	366	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C49
PARP3	Q9Y6F1	337	366	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C49
PCDH9	Q9HC56	1012	1046	24	1237	Chain	ID=PRO_0000003994;Note=Protocadherin-9
PCDH9	Q9HC56	1012	1046	836	1237	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCDH9	Q9HC56	1012	1046	1013	1046	Alternative sequence	ID=VSP_035430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:17974005
PCGF3	Q3KNV8	154	200	1	242	Chain	ID=PRO_0000277864;Note=Polycomb group RING finger protein 3
PCGF3	Q3KNV8	200	227	1	242	Chain	ID=PRO_0000277864;Note=Polycomb group RING finger protein 3
PCGF3	Q3KNV8	154	200	1	242	Chain	ID=PRO_0000277864;Note=Polycomb group RING finger protein 3
PCGF3	Q3KNV8	200	227	1	242	Chain	ID=PRO_0000277864;Note=Polycomb group RING finger protein 3
PCOLCE2	Q9UKZ9	288	316	24	415	Chain	ID=PRO_0000022020;Note=Procollagen C-endopeptidase enhancer 2
PCOLCE2	Q9UKZ9	288	316	297	415	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
PCOLCE2	Q9UKZ9	288	316	297	364	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15113
PCOLCE2	Q9UKZ9	288	316	301	367	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15113
PCOLCE2	Q9UKZ9	288	316	312	415	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15113
PCOLCE2	Q9UKZ9	288	316	292	292	Natural variant	ID=VAR_022448;Note=P->T;Dbxref=dbSNP:rs17554211
PCSK9	Q8NBP7	393	451	153	692	Chain	ID=PRO_0000027121;Note=Proprotein convertase subtilisin/kexin type 9
PCSK9	Q8NBP7	393	451	182	424	Domain	Note=Peptidase S8
PCSK9	Q8NBP7	393	451	450	692	Region	Note=C-terminal domain
PCSK9	Q8NBP7	393	451	366	692	Alternative sequence	ID=VSP_008846;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCSK9	Q8NBP7	393	451	394	394	Natural variant	ID=VAR_067282;Note=Found in a patient associated with autosomal dominant hypercholesterolemia%3B unknown pathological significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22095935;Dbxref=dbSNP:rs368257906,PMID:22095935
PCSK9	Q8NBP7	393	451	417	417	Natural variant	ID=VAR_025455;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs143275858,PMID:16465619
PCSK9	Q8NBP7	393	451	425	425	Natural variant	ID=VAR_021337;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|Ref.4;Dbxref=dbSNP:rs28362261,PMID:16465619
PCSK9	Q8NBP7	393	451	443	443	Natural variant	ID=VAR_021338;Note=Polymorphism%3B associated with lower plasma levels of low-density lipoprotein cholesterol%3B more extensive cleavage by furin and PCSK5. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|Ref.4;Dbxref=dbSNP:rs28362263,PMID:16465619
PCSK9	Q8NBP7	393	451	423	423	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCSK9	Q8NBP7	393	451	385	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMX
PCSK9	Q8NBP7	393	451	408	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMX
PCSK9	Q8NBP7	393	451	419	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMX
PCSK9	Q8NBP7	393	451	426	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMX
PCSK9	Q8NBP7	393	451	431	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMX
PCSK9	Q8NBP7	393	451	434	436	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NMX
PCSK9	Q8NBP7	393	451	440	442	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P5B
PDPR	Q8NCN5	654	684	28	879	Chain	ID=PRO_0000328740;Note=Pyruvate dehydrogenase phosphatase regulatory subunit%2C mitochondrial
PDPR	Q8NCN5	684	745	28	879	Chain	ID=PRO_0000328740;Note=Pyruvate dehydrogenase phosphatase regulatory subunit%2C mitochondrial
PDPR	Q8NCN5	654	684	28	879	Chain	ID=PRO_0000328740;Note=Pyruvate dehydrogenase phosphatase regulatory subunit%2C mitochondrial
PDPR	Q8NCN5	684	745	28	879	Chain	ID=PRO_0000328740;Note=Pyruvate dehydrogenase phosphatase regulatory subunit%2C mitochondrial
PDPR	Q8NCN5	654	684	1	655	Alternative sequence	ID=VSP_056077;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDPR	Q8NCN5	654	684	1	655	Alternative sequence	ID=VSP_056077;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDPR	Q8NCN5	654	684	662	662	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDPR	Q8NCN5	654	684	662	662	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
RSPH10B	P0C881	622	670	1	870	Chain	ID=PRO_0000311943;Note=Radial spoke head 10 homolog B
RSPH10B	P0C881	622	670	1	870	Chain	ID=PRO_0000311943;Note=Radial spoke head 10 homolog B
RSPH10B	P0C881	622	670	1	870	Chain	ID=PRO_0000311943;Note=Radial spoke head 10 homolog B
CBFB	Q13951	55	94	1	182	Chain	ID=PRO_0000058301;Note=Core-binding factor subunit beta
CBFB	Q13951	94	133	1	182	Chain	ID=PRO_0000058301;Note=Core-binding factor subunit beta
CBFB	Q13951	94	133	100	100	Natural variant	ID=VAR_036226;Note=In a breast cancer sample%3B somatic mutation. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
CBFB	Q13951	55	94	52	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	55	94	58	61	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	55	94	65	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	55	94	71	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N9F
CBFB	Q13951	55	94	83	85	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	55	94	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	55	94	94	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	94	133	94	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	94	133	106	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	94	133	116	118	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	94	133	119	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
CBFB	Q13951	94	133	129	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E50
PCBP3	P57721	63	74	1	371	Chain	ID=PRO_0000050092;Note=Poly(rC)-binding protein 3
PCBP3	P57721	74	113	1	371	Chain	ID=PRO_0000050092;Note=Poly(rC)-binding protein 3
PCBP3	P57721	113	157	1	371	Chain	ID=PRO_0000050092;Note=Poly(rC)-binding protein 3
PCBP3	P57721	200	225	1	371	Chain	ID=PRO_0000050092;Note=Poly(rC)-binding protein 3
PCBP3	P57721	225	239	1	371	Chain	ID=PRO_0000050092;Note=Poly(rC)-binding protein 3
PCBP3	P57721	265	285	1	371	Chain	ID=PRO_0000050092;Note=Poly(rC)-binding protein 3
PCBP3	P57721	63	74	45	95	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PCBP3	P57721	74	113	45	95	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PCBP3	P57721	113	157	129	182	Domain	Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PCBP3	P57721	200	225	201	225	Alternative sequence	ID=VSP_009947;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP3	P57721	225	239	201	225	Alternative sequence	ID=VSP_009947;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBP3	P57721	265	285	267	286	Alternative sequence	ID=VSP_010014;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCNP	Q8WW12	93	118	2	178	Chain	ID=PRO_0000058253;Note=PEST proteolytic signal-containing nuclear protein
PCNP	Q8WW12	93	118	1	123	Alternative sequence	ID=VSP_013879;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PDCD10	Q9BUL8	32	50	1	212	Chain	ID=PRO_0000187562;Note=Programmed cell death protein 10
PDCD10	Q9BUL8	32	50	1	212	Chain	ID=PRO_0000187562;Note=Programmed cell death protein 10
PDCD10	Q9BUL8	32	50	1	212	Chain	ID=PRO_0000187562;Note=Programmed cell death protein 10
PDCD10	Q9BUL8	32	50	1	212	Chain	ID=PRO_0000187562;Note=Programmed cell death protein 10
PDCD10	Q9BUL8	32	50	1	212	Chain	ID=PRO_0000187562;Note=Programmed cell death protein 10
PDCD10	Q9BUL8	32	50	26	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	26	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	26	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	26	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	26	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	38	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	38	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	38	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	38	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCD10	Q9BUL8	32	50	38	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH
PDCL3	Q9H2J4	75	122	1	239	Chain	ID=PRO_0000163758;Note=Phosducin-like protein 3
PDCL3	Q9H2J4	75	122	91	239	Region	Note=Thioredoxin fold;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDCD1	Q15116	145	197	21	288	Chain	ID=PRO_0000014892;Note=Programmed cell death protein 1
PDCD1	Q15116	145	197	21	170	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1	Q15116	145	197	171	191	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1	Q15116	145	197	192	288	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1	Q15116	145	197	35	145	Domain	Note=Ig-like V-type
PDCD1	Q15116	145	197	162	162	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDCD1	Q15116	145	197	140	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGS
PDCD4	Q53EL6	147	185	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
PDCD4	Q53EL6	185	259	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
PDCD4	Q53EL6	330	366	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
PDCD4	Q53EL6	366	403	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
PDCD4	Q53EL6	147	185	163	284	Domain	Note=MI 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
PDCD4	Q53EL6	185	259	163	284	Domain	Note=MI 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
PDCD4	Q53EL6	330	366	326	449	Domain	Note=MI 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
PDCD4	Q53EL6	366	403	326	449	Domain	Note=MI 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
PDCD4	Q53EL6	185	259	241	250	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD4	Q53EL6	147	185	152	152	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PDCD4	Q53EL6	147	185	174	174	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19153607;Dbxref=PMID:19153607
PDCD4	Q53EL6	185	259	210	210	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19153607;Dbxref=PMID:19153607
PDCD4	Q53EL6	185	259	249	249	Mutagenesis	Note=Reduced interaction with EIF4A1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19153607;Dbxref=PMID:19153607
PDCD4	Q53EL6	185	259	252	252	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19153607;Dbxref=PMID:19153607
PDCD4	Q53EL6	185	259	253	253	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. Reduced inhibition of EIF4A1 helicase activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19153607,ECO:0000269|PubMed:19204291;Dbxref=PMID:19153607,PMID:19204291
PDCD4	Q53EL6	185	259	255	255	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19153607;Dbxref=PMID:19153607
PDCD4	Q53EL6	330	366	333	333	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation%3B when associated with A-340. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19204291;Dbxref=PMID:19204291
PDCD4	Q53EL6	330	366	337	337	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19204291;Dbxref=PMID:19204291
PDCD4	Q53EL6	330	366	340	340	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation%3B when associated with A-333. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19204291;Dbxref=PMID:19204291
PDCD4	Q53EL6	330	366	358	358	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19153607;Dbxref=PMID:19153607
PDCD4	Q53EL6	330	366	359	359	Mutagenesis	Note=Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19204291;Dbxref=PMID:19204291
PDCD4	Q53EL6	330	366	361	361	Mutagenesis	Note=Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19204291;Dbxref=PMID:19204291
PDCD4	Q53EL6	185	259	220	220	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDCD4	Q53EL6	185	259	222	222	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDCD4	Q53EL6	147	185	161	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	147	185	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	195	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	199	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	213	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	233	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	185	259	257	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RG8
PDCD4	Q53EL6	330	366	324	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDCD4	Q53EL6	330	366	344	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDCD4	Q53EL6	330	366	357	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDCD4	Q53EL6	330	366	360	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDCD4	Q53EL6	366	403	360	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDCD4	Q53EL6	366	403	378	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDCD4	Q53EL6	366	403	398	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
PDE3B	Q13370	343	426	1	1112	Chain	ID=PRO_0000198802;Note=cGMP-inhibited 3'%2C5'-cyclic phosphodiesterase B
PDE3B	Q13370	735	773	1	1112	Chain	ID=PRO_0000198802;Note=cGMP-inhibited 3'%2C5'-cyclic phosphodiesterase B
PDE3B	Q13370	840	908	1	1112	Chain	ID=PRO_0000198802;Note=cGMP-inhibited 3'%2C5'-cyclic phosphodiesterase B
PDE3B	Q13370	735	773	651	1079	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE3B	Q13370	840	908	651	1079	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE3B	Q13370	735	773	737	737	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDE3B	Q13370	735	773	741	741	Metal binding	Note=Divalent metal cation 1
PDE3B	Q13370	343	426	376	426	Alternative sequence	ID=VSP_054138;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDE3B	Q13370	735	773	735	738	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	735	773	739	752	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	839	843	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	844	846	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	849	863	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	866	868	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	870	873	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	876	891	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	895	897	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE3B	Q13370	840	908	898	909	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SO2
PDE6D	O43924	46	88	1	150	Chain	ID=PRO_0000221208;Note=Retinal rod rhodopsin-sensitive cGMP 3'%2C5'-cyclic phosphodiesterase subunit delta
PDE6D	O43924	46	88	43	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ML3
PDE6D	O43924	46	88	51	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ML3
PDE6D	O43924	46	88	57	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ML3
PDE6D	O43924	46	88	71	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ML3
PDE6D	O43924	46	88	85	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ML3
PDCD7	Q8N8D1	336	415	1	485	Chain	ID=PRO_0000058269;Note=Programmed cell death protein 7
PDCD7	Q8N8D1	336	415	362	411	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PDE4B	Q07343	340	373	1	736	Chain	ID=PRO_0000198809;Note=cAMP-specific 3'%2C5'-cyclic phosphodiesterase 4B
PDE4B	Q07343	554	615	1	736	Chain	ID=PRO_0000198809;Note=cAMP-specific 3'%2C5'-cyclic phosphodiesterase 4B
PDE4B	Q07343	340	373	330	659	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE4B	Q07343	554	615	330	659	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE4B	Q07343	554	615	564	564	Metal binding	Note=Divalent metal cation 1
PDE4B	Q07343	554	615	564	564	Binding site	Note=cAMP
PDE4B	Q07343	554	615	615	615	Binding site	Note=cAMP
PDE4B	Q07343	554	615	567	567	Site	Note=Binds AMP%2C but not cAMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDE4B	Q07343	340	373	335	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	340	373	343	346	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	340	373	352	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	340	373	359	361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RO6
PDE4B	Q07343	340	373	363	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	554	615	549	564	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	554	615	567	569	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	554	615	572	595	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	554	615	602	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FRG
PDE4B	Q07343	554	615	606	608	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE4B	Q07343	554	615	611	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KP6
PDE3A	Q14432	855	923	1	1141	Chain	ID=PRO_0000198799;Note=cGMP-inhibited 3'%2C5'-cyclic phosphodiesterase A
PDE3A	Q14432	855	923	674	1093	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE3A	Q14432	855	923	870	873	Compositional bias	Note=Poly-Ala
PELI3	Q8N2H9	51	74	1	469	Chain	ID=PRO_0000194176;Note=E3 ubiquitin-protein ligase pellino homolog 3
PELI3	Q8N2H9	118	152	1	469	Chain	ID=PRO_0000194176;Note=E3 ubiquitin-protein ligase pellino homolog 3
PELI3	Q8N2H9	51	74	48	110	Alternative sequence	ID=VSP_008639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PELI3	Q8N2H9	51	74	52	75	Alternative sequence	ID=VSP_008640;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12874243,ECO:0000303|PubMed:15489334;Dbxref=PMID:12874243,PMID:15489334
PELI3	Q8N2H9	51	74	73	73	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCNA	P12004	129	194	1	261	Chain	ID=PRO_0000149158;Note=Proliferating cell nuclear antigen
PCNA	P12004	129	194	1	261	Chain	ID=PRO_0000149158;Note=Proliferating cell nuclear antigen
PCNA	P12004	129	194	164	164	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25755297,PMID:25772364,PMID:28112733
PCNA	P12004	129	194	164	164	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25755297,PMID:25772364,PMID:28112733
PCNA	P12004	129	194	164	164	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17108083,ECO:0000269|PubMed:17130289;Dbxref=PMID:17108083,PMID:17130289
PCNA	P12004	129	194	164	164	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17108083,ECO:0000269|PubMed:17130289;Dbxref=PMID:17108083,PMID:17130289
PCNA	P12004	129	194	164	164	Mutagenesis	Note=Abolishes ubiquitination. No effect on interaction with SHPRH. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17108083,ECO:0000269|PubMed:17130289,ECO:0000269|PubMed:18719106,ECO:0000269|PubMed:20129063;Dbxref=PMID:17108083,PMID:17130289,PMID:18719106,PMID:20129063
PCNA	P12004	129	194	164	164	Mutagenesis	Note=Abolishes ubiquitination. No effect on interaction with SHPRH. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17108083,ECO:0000269|PubMed:17130289,ECO:0000269|PubMed:18719106,ECO:0000269|PubMed:20129063;Dbxref=PMID:17108083,PMID:17130289,PMID:18719106,PMID:20129063
PCNA	P12004	129	194	188	190	Mutagenesis	Note=No effect on POLD3-binding. VDK->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11595739;Dbxref=PMID:11595739
PCNA	P12004	129	194	188	190	Mutagenesis	Note=No effect on POLD3-binding. VDK->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11595739;Dbxref=PMID:11595739
PCNA	P12004	129	194	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	141	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	141	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	156	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	156	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	166	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	166	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	176	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	176	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U7B
PCNA	P12004	129	194	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E0U
PCNA	P12004	129	194	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E0U
PCOLCE	Q15113	313	337	26	449	Chain	ID=PRO_0000022023;Note=Procollagen C-endopeptidase enhancer 1
PCOLCE	Q15113	313	337	318	437	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
PCOLCE	Q15113	313	337	318	386	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12670942;Dbxref=PMID:12670942
PCOLCE	Q15113	313	337	322	389	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12670942;Dbxref=PMID:12670942
PCOLCE	Q15113	313	337	333	437	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12670942;Dbxref=PMID:12670942
PCOLCE	Q15113	313	337	328	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UAP
PCOLCE	Q15113	313	337	336	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UAP
PCSK7	Q16549	441	477	142	785	Chain	ID=PRO_0000027115;Note=Proprotein convertase subtilisin/kexin type 7
PCSK7	Q16549	441	477	142	667	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCSK7	Q16549	441	477	182	474	Domain	Note=Peptidase S8
PCYT2	Q99447	301	323	1	389	Chain	ID=PRO_0000208461;Note=Ethanolamine-phosphate cytidylyltransferase
PCYT2	Q99447	279	301	1	389	Chain	ID=PRO_0000208461;Note=Ethanolamine-phosphate cytidylyltransferase
PCYT2	Q99447	253	279	1	389	Chain	ID=PRO_0000208461;Note=Ethanolamine-phosphate cytidylyltransferase
PCYT2	Q99447	164	179	1	389	Chain	ID=PRO_0000208461;Note=Ethanolamine-phosphate cytidylyltransferase
PCYT2	Q99447	59	113	1	389	Chain	ID=PRO_0000208461;Note=Ethanolamine-phosphate cytidylyltransferase
PCYT2	Q99447	301	323	307	310	Nucleotide binding	Note=CTP
PCYT2	Q99447	253	279	259	259	Binding site	Note=CTP
PCYT2	Q99447	59	113	1	78	Alternative sequence	ID=VSP_045131;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCYT2	Q99447	164	179	179	179	Alternative sequence	ID=VSP_046844;Note=In isoform 3. K->KPPHPIPAGDILSSEGCSQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCYT2	Q99447	59	113	59	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	59	113	73	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	59	113	88	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	59	113	99	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	59	113	108	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	253	279	252	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	253	279	268	276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	279	301	283	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	279	301	294	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	301	323	303	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PCYT2	Q99447	301	323	323	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ELB
PDCD6IP	Q8WUM4	239	278	2	868	Chain	ID=PRO_0000218891;Note=Programmed cell death 6-interacting protein
PDCD6IP	Q8WUM4	239	278	3	392	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
PDCD6IP	Q8WUM4	239	278	176	868	Region	Note=Interaction with EIAV p9
PDCD6IP	Q8WUM4	239	278	176	503	Region	Note=Interaction with CHMP4A%2C CHMP4B and CHMP4C
PDCD6IP	Q8WUM4	239	278	239	239	Alternative sequence	ID=VSP_044860;Note=In isoform 2. K->KYFYFQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDCD6IP	Q8WUM4	239	278	240	271	Alternative sequence	ID=VSP_057190;Note=In isoform 3. EVFPVLAAKHCIMQANAEYHQSILAKQQKKFG->VSYCFYKHLLTLHVKYLDFFVYKKQVETYKEI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19906316;Dbxref=PMID:19906316
PDCD6IP	Q8WUM4	239	278	272	868	Alternative sequence	ID=VSP_057191;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19906316;Dbxref=PMID:19906316
PDCD6IP	Q8WUM4	239	278	241	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C3R
PDCD6IP	Q8WUM4	239	278	270	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C3R
PDE5A	O76074	802	830	1	875	Chain	ID=PRO_0000198823;Note=cGMP-specific 3'%2C5'-cyclic phosphodiesterase
PDE5A	O76074	777	802	1	875	Chain	ID=PRO_0000198823;Note=cGMP-specific 3'%2C5'-cyclic phosphodiesterase
PDE5A	O76074	593	635	1	875	Chain	ID=PRO_0000198823;Note=cGMP-specific 3'%2C5'-cyclic phosphodiesterase
PDE5A	O76074	544	593	1	875	Chain	ID=PRO_0000198823;Note=cGMP-specific 3'%2C5'-cyclic phosphodiesterase
PDE5A	O76074	802	830	536	860	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE5A	O76074	777	802	536	860	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE5A	O76074	593	635	536	860	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE5A	O76074	544	593	536	860	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE5A	O76074	593	635	613	613	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O76083
PDE5A	O76074	593	635	617	617	Metal binding	Note=Zinc%3B via tele nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12955149;Dbxref=PMID:12955149
PDE5A	O76074	802	830	817	817	Binding site	Note=cGMP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12955149;Dbxref=PMID:12955149
PDE5A	O76074	544	593	535	545	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	544	593	551	554	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	544	593	555	557	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	544	593	568	581	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	544	593	584	587	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	593	635	592	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	544	593	592	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	593	635	606	608	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T9R
PDE5A	O76074	593	635	610	614	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	593	635	615	630	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	593	635	631	633	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UHO
PDE5A	O76074	593	635	635	637	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	777	802	772	796	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	802	830	803	805	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	802	830	807	812	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	802	830	813	823	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDE5A	O76074	802	830	825	835	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TBF
PDIA2	Q13087	226	265	22	525	Chain	ID=PRO_0000034222;Note=Protein disulfide-isomerase A2
PDIA2	Q13087	265	307	22	525	Chain	ID=PRO_0000034222;Note=Protein disulfide-isomerase A2
PDIA2	Q13087	307	373	22	525	Chain	ID=PRO_0000034222;Note=Protein disulfide-isomerase A2
PDIA2	Q13087	474	511	22	525	Chain	ID=PRO_0000034222;Note=Protein disulfide-isomerase A2
PDIA2	Q13087	307	373	367	496	Domain	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PDIA2	Q13087	474	511	367	496	Domain	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PDIA2	Q13087	474	511	482	482	Site	Note=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDIA2	Q13087	265	307	284	284	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23167757;Dbxref=PMID:23167757
PDIA2	Q13087	265	307	286	286	Natural variant	ID=VAR_048090;Note=T->M;Dbxref=dbSNP:rs2685127
PDIA2	Q13087	474	511	502	502	Natural variant	ID=VAR_048093;Note=P->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8561901,ECO:0000269|Ref.1;Dbxref=dbSNP:rs1048786,PMID:15489334,PMID:8561901
PDIA2	Q13087	265	307	284	284	Mutagenesis	Note=Increases formation of a highly stable disulfide-bonded PDIA2 dimer. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23167757;Dbxref=PMID:23167757
PDIA2	Q13087	307	373	364	364	Mutagenesis	Note=No effect on interchain disulfide bridge formation. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19150607;Dbxref=PMID:19150607
PDIA2	Q13087	474	511	484	484	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDE6A	P16499	676	711	2	857	Chain	ID=PRO_0000198828;Note=Rod cGMP-specific 3'%2C5'-cyclic phosphodiesterase subunit alpha
PDE6A	P16499	421	469	2	857	Chain	ID=PRO_0000198828;Note=Rod cGMP-specific 3'%2C5'-cyclic phosphodiesterase subunit alpha
PDE6A	P16499	421	469	254	431	Domain	Note=GAF 2
PDE6A	P16499	676	711	483	816	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE11A	Q9HCR9	829	854	1	933	Chain	ID=PRO_0000247040;Note=Dual 3'%2C5'-cyclic-AMP and -GMP phosphodiesterase 11A
PDE11A	Q9HCR9	579	596	1	933	Chain	ID=PRO_0000247040;Note=Dual 3'%2C5'-cyclic-AMP and -GMP phosphodiesterase 11A
PDE11A	Q9HCR9	548	579	1	933	Chain	ID=PRO_0000247040;Note=Dual 3'%2C5'-cyclic-AMP and -GMP phosphodiesterase 11A
PDE11A	Q9HCR9	548	579	402	558	Domain	Note=GAF 2
PDE11A	Q9HCR9	829	854	588	912	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE11A	Q9HCR9	579	596	588	912	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDIA3	P30101	121	157	25	505	Chain	ID=PRO_0000034225;Note=Protein disulfide-isomerase A3
PDIA3	P30101	201	239	25	505	Chain	ID=PRO_0000034225;Note=Protein disulfide-isomerase A3
PDIA3	P30101	240	281	25	505	Chain	ID=PRO_0000034225;Note=Protein disulfide-isomerase A3
PDIA3	P30101	282	342	25	505	Chain	ID=PRO_0000034225;Note=Protein disulfide-isomerase A3
PDIA3	P30101	379	422	25	505	Chain	ID=PRO_0000034225;Note=Protein disulfide-isomerase A3
PDIA3	P30101	121	157	25	133	Domain	Note=Thioredoxin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PDIA3	P30101	379	422	343	485	Domain	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PDIA3	P30101	379	422	406	406	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDIA3	P30101	379	422	409	409	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDIA3	P30101	379	422	407	407	Site	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDIA3	P30101	379	422	408	408	Site	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDIA3	P30101	121	157	129	129	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27773
PDIA3	P30101	121	157	152	152	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27773
PDIA3	P30101	201	239	218	218	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27773
PDIA3	P30101	240	281	252	252	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27773
PDIA3	P30101	282	342	319	319	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PDIA3	P30101	379	422	406	409	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PDIA3	P30101	379	422	415	415	Natural variant	ID=VAR_020027;Note=K->R;Dbxref=dbSNP:rs6413485
PDIA3	P30101	379	422	406	406	Mutagenesis	Note=No loss of activity. No loss of activity%3B when associated with A-57. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9399589;Dbxref=PMID:9399589
PDIA3	P30101	379	422	406	406	Mutagenesis	Note=Activity changed to serine protease. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9399589;Dbxref=PMID:9399589
PDIA3	P30101	379	422	409	409	Mutagenesis	Note=Activity changed to serine protease%3B when associated with S-60. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9399589;Dbxref=PMID:9399589
PDIA3	P30101	201	239	217	217	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDIA3	P30101	201	239	225	225	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDIA3	P30101	201	239	238	238	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDIA3	P30101	240	281	272	272	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDIA3	P30101	240	281	272	272	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDIA3	P30101	121	157	121	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	121	157	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	121	157	142	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	121	157	151	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	121	157	155	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	201	239	198	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	201	239	209	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	201	239	218	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	201	239	229	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	240	281	240	243	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	240	281	249	251	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	240	281	252	255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	240	281	256	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	240	281	269	271	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	240	281	273	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	273	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	298	303	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	304	307	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	308	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	312	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	325	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	282	342	331	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	282	342	335	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H8L
PDIA3	P30101	379	422	376	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	379	422	383	385	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	379	422	386	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	379	422	396	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA3	P30101	379	422	407	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F8U
PDIA4	P13667	429	507	21	645	Chain	ID=PRO_0000034229;Note=Protein disulfide-isomerase A4
PDIA4	P13667	429	507	505	636	Domain	Note=Thioredoxin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
PDPK1	O15530	262	284	1	556	Chain	ID=PRO_0000086500;Note=3-phosphoinositide-dependent protein kinase 1
PDPK1	O15530	467	518	1	556	Chain	ID=PRO_0000086500;Note=3-phosphoinositide-dependent protein kinase 1
PDPK1	O15530	262	284	82	342	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PDPK1	O15530	467	518	459	550	Domain	Note=PH
PDPK1	O15530	467	518	501	501	Modified residue	Note=Phosphoserine%3B by PKC/PRKCQ;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2A0
PDPK1	O15530	467	518	513	513	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16780920;Dbxref=PMID:16780920
PDPK1	O15530	262	284	238	263	Alternative sequence	ID=VSP_004895;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9445477;Dbxref=PMID:9445477
PDPK1	O15530	467	518	448	556	Alternative sequence	ID=VSP_044796;Note=In isoform 5. WHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ->CLTGRII;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
PDPK1	O15530	262	284	277	277	Mutagenesis	Note=3-fold increase in kinase activity. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10364160;Dbxref=PMID:10364160
PDPK1	O15530	467	518	474	474	Mutagenesis	Note=No PDGF-dependent translocation to the membrane. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9637919;Dbxref=PMID:9637919
PDPK1	O15530	467	518	513	513	Mutagenesis	Note=Enhanced kinase activity towards PKB. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20978239;Dbxref=PMID:20978239
PDPK1	O15530	262	284	261	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LVO
PDPK1	O15530	467	518	457	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
PDPK1	O15530	467	518	470	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
PDPK1	O15530	467	518	480	482	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
PDPK1	O15530	467	518	483	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
PDPK1	O15530	467	518	489	492	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
PDPK1	O15530	467	518	493	498	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
PDPK1	O15530	467	518	505	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W1G
RSPH10B2	B2RC85	622	670	1	870	Chain	ID=PRO_0000349254;Note=Radial spoke head 10 homolog B2
RSPH10B2	B2RC85	622	670	1	870	Chain	ID=PRO_0000349254;Note=Radial spoke head 10 homolog B2
RSPH10B2	B2RC85	622	670	1	870	Chain	ID=PRO_0000349254;Note=Radial spoke head 10 homolog B2
RSPH10B2	B2RC85	622	670	515	870	Alternative sequence	ID=VSP_035279;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RSPH10B2	B2RC85	622	670	515	870	Alternative sequence	ID=VSP_035279;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RSPH10B2	B2RC85	622	670	515	870	Alternative sequence	ID=VSP_035279;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RAD51C	O43502	235	279	1	376	Chain	ID=PRO_0000122941;Note=DNA repair protein RAD51 homolog 3
RAD51C	O43502	235	279	136	376	Alternative sequence	ID=VSP_043657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9469824;Dbxref=PMID:9469824
RAD51C	O43502	235	279	249	249	Natural variant	ID=VAR_020519;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21990120,ECO:0000269|Ref.2;Dbxref=dbSNP:rs28363311,PMID:21990120
RAD51C	O43502	235	279	258	258	Natural variant	ID=VAR_064032;Note=In FANCO%3B possibly hypomorphic allele%3B reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20400963,ECO:0000269|PubMed:24141787;Dbxref=dbSNP:rs267606997,PMID:20400963,PMID:24141787
RAD51C	O43502	235	279	262	262	Natural variant	ID=VAR_068020;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990120;Dbxref=dbSNP:rs149331537,PMID:21990120
RAD51C	O43502	235	279	264	264	Natural variant	ID=VAR_063843;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20400964,ECO:0000269|PubMed:21990120;Dbxref=dbSNP:rs147241704,PMID:20400964,PMID:21990120
RAD51C	O43502	235	279	264	264	Natural variant	ID=VAR_063844;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20400964;Dbxref=PMID:20400964
PES1	O00541	348	389	1	588	Chain	ID=PRO_0000186188;Note=Pescadillo homolog
PES1	O00541	274	304	1	588	Chain	ID=PRO_0000186188;Note=Pescadillo homolog
PES1	O00541	249	274	1	588	Chain	ID=PRO_0000186188;Note=Pescadillo homolog
PES1	O00541	348	389	322	415	Domain	Note=BRCT;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03028
PES1	O00541	249	274	1	257	Region	Note=Sufficient for nucleolar localization
PES1	O00541	348	389	306	415	Region	Note=Sufficient for interaction with MAP1B;Ontology_term=ECO:0000250;evidence=ECO:0000250
PES1	O00541	249	274	264	264	Natural variant	ID=VAR_034375;Note=T->S;Dbxref=dbSNP:rs42942
PES1	O00541	348	389	370	370	Natural variant	ID=VAR_053570;Note=D->H;Dbxref=dbSNP:rs11541876
PES1	O00541	348	389	380	380	Mutagenesis	Note=Slightly impairs nucleolar localization. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17189298;Dbxref=PMID:17189298
PES1	O00541	348	389	340	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EP8
PES1	O00541	348	389	353	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EP8
PES1	O00541	348	389	358	360	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EP8
PES1	O00541	348	389	375	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EP8
PES1	O00541	348	389	381	383	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EP8
NTRK3	Q16288	711	725	32	839	Chain	ID=PRO_0000016731;Note=NT-3 growth factor receptor
NTRK3	Q16288	465	528	32	839	Chain	ID=PRO_0000016731;Note=NT-3 growth factor receptor
NTRK3	Q16288	132	154	32	839	Chain	ID=PRO_0000016731;Note=NT-3 growth factor receptor
NTRK3	Q16288	132	154	32	429	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK3	Q16288	711	725	454	839	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK3	Q16288	465	528	454	839	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK3	Q16288	132	154	128	149	Repeat	Note=LRR 2
NTRK3	Q16288	711	725	538	839	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NTRK3	Q16288	465	528	516	516	Site	Note=Interaction with SHC1;Ontology_term=ECO:0000250;evidence=ECO:0000250
NTRK3	Q16288	465	528	493	493	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6VNS1
NTRK3	Q16288	465	528	516	516	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25196463;Dbxref=PMID:25196463
NTRK3	Q16288	132	154	133	133	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK3	Q16288	711	725	613	839	Alternative sequence	ID=VSP_002926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7823156;Dbxref=PMID:7823156
NTRK3	Q16288	711	725	712	725	Alternative sequence	ID=VSP_002927;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7806211,ECO:0000303|PubMed:7823156;Dbxref=PMID:14702039,PMID:7806211,PMID:7823156
NTRK3	Q16288	132	154	149	149	Natural variant	ID=VAR_041471;Note=In a gastric adenocarcinoma sample%3B somatic mutation. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs368222977,PMID:17344846
NUP50	Q9UKX7	113	334	1	468	Chain	ID=PRO_0000204868;Note=Nuclear pore complex protein Nup50
NUP50	Q9UKX7	113	334	113	114	Repeat	Note=2
NUP50	Q9UKX7	113	334	225	226	Repeat	Note=3
NUP50	Q9UKX7	113	334	273	274	Repeat	Note=4
NUP50	Q9UKX7	113	334	303	304	Repeat	Note=5
NUP50	Q9UKX7	113	334	76	304	Region	Note=5 X 2 AA repeats of F-G
NUP50	Q9UKX7	113	334	144	206	Region	Note=Binding to CDKN1B;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUP50	Q9UKX7	113	334	268	330	Compositional bias	Note=Ser-rich
NUP50	Q9UKX7	113	334	127	127	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JIH2
NUP50	Q9UKX7	113	334	208	208	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP50	Q9UKX7	113	334	221	221	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
NUP50	Q9UKX7	113	334	234	234	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JIH2
NUP50	Q9UKX7	113	334	246	246	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NUP50	Q9UKX7	113	334	259	259	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NUP50	Q9UKX7	113	334	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP50	Q9UKX7	113	334	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NUP50	Q9UKX7	113	334	235	235	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP88	Q99567	612	638	2	741	Chain	ID=PRO_0000204887;Note=Nuclear pore complex protein Nup88
NUP88	Q99567	548	589	2	741	Chain	ID=PRO_0000204887;Note=Nuclear pore complex protein Nup88
NUP88	Q99567	495	547	2	741	Chain	ID=PRO_0000204887;Note=Nuclear pore complex protein Nup88
NUP88	Q99567	461	494	2	741	Chain	ID=PRO_0000204887;Note=Nuclear pore complex protein Nup88
NUP88	Q99567	397	430	2	741	Chain	ID=PRO_0000204887;Note=Nuclear pore complex protein Nup88
NUP88	Q99567	198	226	2	741	Chain	ID=PRO_0000204887;Note=Nuclear pore complex protein Nup88
NUP88	Q99567	612	638	585	651	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUP88	Q99567	548	589	585	651	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUP88	Q99567	495	547	517	517	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
NUP88	Q99567	495	547	525	525	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:20068231,PMID:23186163
NUP88	Q99567	495	547	540	540	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NUP88	Q99567	495	547	518	518	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NVL	O15381	654	694	1	856	Chain	ID=PRO_0000084588;Note=Nuclear valosin-containing protein-like
NVL	O15381	633	654	1	856	Chain	ID=PRO_0000084588;Note=Nuclear valosin-containing protein-like
NVL	O15381	320	354	1	856	Chain	ID=PRO_0000084588;Note=Nuclear valosin-containing protein-like
NVL	O15381	275	320	1	856	Chain	ID=PRO_0000084588;Note=Nuclear valosin-containing protein-like
NVL	O15381	114	205	1	856	Chain	ID=PRO_0000084588;Note=Nuclear valosin-containing protein-like
NVL	O15381	275	320	305	312	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22226966;Dbxref=PMID:22226966
NVL	O15381	114	205	1	220	Region	Note=Interaction with RPL5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15469983;Dbxref=PMID:15469983
NVL	O15381	320	354	267	474	Region	Note=Interaction with WDR74;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28416111;Dbxref=PMID:28416111
NVL	O15381	275	320	267	474	Region	Note=Interaction with WDR74;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28416111;Dbxref=PMID:28416111
NVL	O15381	114	205	134	134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
NVL	O15381	114	205	138	138	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
NVL	O15381	114	205	156	156	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBY8
NVL	O15381	114	205	191	191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBY8
NVL	O15381	114	205	1	216	Alternative sequence	ID=VSP_045334;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NVL	O15381	114	205	115	205	Alternative sequence	ID=VSP_007772;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
NVL	O15381	320	354	320	320	Alternative sequence	ID=VSP_045335;Note=In isoform 4. G->GAECSGMITAHCSFDFSGSNDPPASASQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NVL	O15381	275	320	320	320	Alternative sequence	ID=VSP_045335;Note=In isoform 4. G->GAECSGMITAHCSFDFSGSNDPPASASQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NVL	O15381	275	320	295	295	Natural variant	ID=VAR_048109;Note=V->I;Dbxref=dbSNP:rs12084919
NVL	O15381	275	320	311	311	Mutagenesis	Note=Loss of ATP-binding. Significant reduction in interaction with TERT and in telomerase activity. Loss of interaction with MTREX. K->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:16782053,ECO:0000269|PubMed:22226966,ECO:0000305|PubMed:22226966;Dbxref=PMID:16782053,PMID:22226966,PMID:22226966
NVL	O15381	654	694	682	682	Mutagenesis	Note=Decreases 60S ribosomes synthesis. Strongly decreases 60S ribosomal subunit synthesis%2C enhances interaction with WDR74 and increases association of WDR74 and MTREX as well as induces partial migration of WDR74 to the nucleoplasm%3B when associated with Q-365. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26166824,ECO:0000269|PubMed:26456651;Dbxref=PMID:26166824,PMID:26456651
NVL	O15381	633	654	628	638	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X8A
NVL	O15381	633	654	642	647	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X8A
NVL	O15381	633	654	648	651	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X8A
NVL	O15381	654	694	657	672	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X8A
NVL	O15381	654	694	675	681	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X8A
NVL	O15381	654	694	684	686	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X8A
NWD1	Q149M9	590	657	1	1564	Chain	ID=PRO_0000308254;Note=NACHT domain- and WD repeat-containing protein 1
NWD1	Q149M9	590	657	335	661	Domain	Note=NACHT
NWD1	Q149M9	590	657	77	1564	Alternative sequence	ID=VSP_040652;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OBP2B	Q9NPH6	92	129	16	170	Chain	ID=PRO_0000017938;Note=Odorant-binding protein 2b
OBP2B	Q9NPH6	92	129	74	166	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
OBP2B	Q9NPH6	92	129	25	170	Alternative sequence	ID=VSP_003139;Note=In isoform Bg. ITGTWYVKAMVVDKDFPEDRRPRKVSPVKVTALGGGKLEATFTFMREDRCIQKKILMRKTEEPGKYSAYGGRKLMYLQELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDTNREALEEFKKLVQRKGLSEEDIFTPLQTGSCVPEH->EGGSVHPEENPDAEDGGAWQIQRLWGQEAHIPAGAAQEGPLHLLLQRPAPWGPAPHGKACG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10607840;Dbxref=PMID:10607840
OBP2B	Q9NPH6	92	129	93	170	Alternative sequence	ID=VSP_003138;Note=In isoform Bb. YGGRKLMYLQELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDTNREALEEFKKLVQRKGLSEEDIFTPLQTGSCVPEH->CLSAVEMDQITPALWEALAIDTLRKLRIGTRRPRIRWGQEAHVPAGAAQEGPLHLLLQRPAPWGPAPHGKACG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10607840;Dbxref=PMID:10607840
OGT	O15294	154	177	2	1046	Chain	ID=PRO_0000191772;Note=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
OGT	O15294	177	216	2	1046	Chain	ID=PRO_0000191772;Note=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
OGT	O15294	617	659	2	1046	Chain	ID=PRO_0000191772;Note=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
OGT	O15294	716	755	2	1046	Chain	ID=PRO_0000191772;Note=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
OGT	O15294	812	863	2	1046	Chain	ID=PRO_0000191772;Note=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
OGT	O15294	154	177	123	156	Repeat	Note=TPR 3
OGT	O15294	154	177	157	190	Repeat	Note=TPR 4
OGT	O15294	177	216	157	190	Repeat	Note=TPR 4
OGT	O15294	177	216	191	224	Repeat	Note=TPR 5
OGT	O15294	812	863	849	849	Binding site	Note=UDP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4GYW,ECO:0000269|PubMed:23103939;Dbxref=PMID:23103939
OGT	O15294	812	863	852	852	Binding site	Note=UDP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4GYW,ECO:0000269|PubMed:23103939;Dbxref=PMID:23103939
OGT	O15294	154	177	1	381	Alternative sequence	ID=VSP_040764;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
OGT	O15294	177	216	1	381	Alternative sequence	ID=VSP_040764;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
OGT	O15294	154	177	1	176	Alternative sequence	ID=VSP_006553;Note=In isoform 2. MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEA->MLQGHFWLVREGIMISPSSPPPPNLFFFPLQIFPFPFTSFPSHLLSLTPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9083068;Dbxref=PMID:9083068
OGT	O15294	177	216	208	208	Mutagenesis	Note=Abolishes homodimerization of the TPR domain. Slightly reduced enzyme activity%3B when associated with D-211. W->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15361863;Dbxref=PMID:15361863
OGT	O15294	177	216	211	211	Mutagenesis	Note=Abolishes homodimerization of the TPR domain. Slightly reduced enzyme activity%3B when associated with E-208. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15361863;Dbxref=PMID:15361863
OGT	O15294	154	177	157	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EOU
OGT	O15294	154	177	173	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EOU
OGT	O15294	177	216	173	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EOU
OGT	O15294	177	216	191	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EOU
OGT	O15294	177	216	207	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EOU
OGT	O15294	617	659	615	617	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	617	659	621	631	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	617	659	634	639	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	617	659	641	643	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	617	659	649	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	617	659	656	664	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	716	755	719	722	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	716	755	731	737	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	716	755	741	746	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	716	755	748	750	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GYW
OGT	O15294	716	755	752	755	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	810	813	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	815	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	820	822	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AY5
OGT	O15294	812	863	825	831	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	832	835	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	839	841	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LVV
OGT	O15294	812	863	843	845	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	850	852	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGT	O15294	812	863	855	867	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NPS
OGFOD2	Q6N063	44	63	1	350	Chain	ID=PRO_0000288978;Note=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
OGFOD2	Q6N063	63	101	1	350	Chain	ID=PRO_0000288978;Note=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
OGFOD2	Q6N063	44	63	1	164	Alternative sequence	ID=VSP_025855;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OGFOD2	Q6N063	63	101	1	164	Alternative sequence	ID=VSP_025855;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OGFOD2	Q6N063	44	63	1	60	Alternative sequence	ID=VSP_025856;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
OGFOD2	Q6N063	44	63	61	62	Alternative sequence	ID=VSP_025857;Note=In isoform 2. LA->MV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
OGFOD2	Q6N063	63	101	64	64	Alternative sequence	ID=VSP_025858;Note=In isoform 3. L->WPQEDGRPHLVTTLCHPSLSRRWSGGSGWGRSQQLGKPSSRVPTTRHGLRSTTHCRMQLWPPSSWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
OGFOD2	Q6N063	63	101	65	350	Alternative sequence	ID=VSP_025859;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NDUFS8	O00217	19	36	1	34	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS8	O00217	19	36	35	210	Chain	ID=PRO_0000020012;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 8%2C mitochondrial
NDUFS8	O00217	36	66	35	210	Chain	ID=PRO_0000020012;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 8%2C mitochondrial
NDUFS8	O00217	124	167	35	210	Chain	ID=PRO_0000020012;Note=NADH dehydrogenase [ubiquinone] iron-sulfur protein 8%2C mitochondrial
NDUFS8	O00217	124	167	102	131	Domain	Note=4Fe-4S ferredoxin-type 1
NDUFS8	O00217	124	167	141	170	Domain	Note=4Fe-4S ferredoxin-type 2
NDUFS8	O00217	124	167	150	150	Metal binding	Note=Iron-sulfur 2 (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS8	O00217	124	167	153	153	Metal binding	Note=Iron-sulfur 2 (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS8	O00217	124	167	156	156	Metal binding	Note=Iron-sulfur 2 (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS8	O00217	124	167	160	160	Metal binding	Note=Iron-sulfur 1 (4Fe-4S);Ontology_term=ECO:0000250;evidence=ECO:0000250
NDUFS8	O00217	19	36	36	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	36	66	36	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	36	66	48	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	36	66	63	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	124	167	130	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	124	167	138	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	124	167	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	124	167	147	149	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	124	167	155	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFS8	O00217	124	167	165	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFAF6	Q330K2	99	140	45	333	Chain	ID=PRO_0000291772;Note=NADH dehydrogenase (ubiquinone) complex I%2C assembly factor 6
NDUFAF6	Q330K2	140	159	45	333	Chain	ID=PRO_0000291772;Note=NADH dehydrogenase (ubiquinone) complex I%2C assembly factor 6
NDUFAF6	Q330K2	272	291	45	333	Chain	ID=PRO_0000291772;Note=NADH dehydrogenase (ubiquinone) complex I%2C assembly factor 6
NDUFAF6	Q330K2	99	140	100	120	Alternative sequence	ID=VSP_026231;Note=In isoform 3. VKDSVSEKTIGLMRMQFWKKT->AGLLLLLSCCTVCHWDLNTKHC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
NDUFAF6	Q330K2	99	140	121	333	Alternative sequence	ID=VSP_026232;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
NDUFAF6	Q330K2	140	159	121	333	Alternative sequence	ID=VSP_026232;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
NDUFAF6	Q330K2	272	291	121	333	Alternative sequence	ID=VSP_026232;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
NDUFAF6	Q330K2	99	140	99	99	Natural variant	ID=VAR_047770;Note=In MT-C1D. Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18614015,ECO:0000269|PubMed:22019594;Dbxref=dbSNP:rs137853184,PMID:18614015,PMID:22019594
NDUFAF6	Q330K2	99	140	124	124	Natural variant	ID=VAR_076274;Note=In MT-C1D. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26741492;Dbxref=dbSNP:rs201732170,PMID:26741492
NDUFAF6	Q330K2	272	291	274	274	Natural variant	ID=VAR_076276;Note=In MT-C1D. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26741492;Dbxref=dbSNP:rs1057519086,PMID:26741492
NKD1	Q969G9	122	154	2	470	Chain	ID=PRO_0000301990;Note=Protein naked cuticle homolog 1
NKD1	Q969G9	122	154	131	166	Domain	Note=EF-hand;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NKD1	Q969G9	122	154	144	155	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NKD1	Q969G9	122	154	125	190	Region	Note=Interaction with DVL1%2C DVL2 and DVL3;Ontology_term=ECO:0000250;evidence=ECO:0000250
KLRC1	P26715	94	112	1	233	Chain	ID=PRO_0000046659;Note=NKG2-A/NKG2-B type II integral membrane protein
KLRC1	P26715	94	112	1	233	Chain	ID=PRO_0000046659;Note=NKG2-A/NKG2-B type II integral membrane protein
KLRC1	P26715	94	112	94	233	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRC1	P26715	94	112	94	233	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRC1	P26715	94	112	102	102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRC1	P26715	94	112	102	102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRC1	P26715	94	112	103	103	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRC1	P26715	94	112	103	103	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KLRC1	P26715	94	112	96	113	Alternative sequence	ID=VSP_003062;Note=In isoform NKG2-B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2007850;Dbxref=PMID:15489334,PMID:2007850
KLRC1	P26715	94	112	96	113	Alternative sequence	ID=VSP_003062;Note=In isoform NKG2-B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2007850;Dbxref=PMID:15489334,PMID:2007850
NKAIN2	Q5VXU1	64	91	1	208	Chain	ID=PRO_0000265088;Note=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
NKAIN2	Q5VXU1	91	158	1	208	Chain	ID=PRO_0000265088;Note=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
NKAIN2	Q5VXU1	64	91	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKAIN2	Q5VXU1	91	158	153	173	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKAIN2	Q5VXU1	64	91	91	92	Site	Note=Breakpoint for interstitial deletion to form SUSP1-NKAIN2
NKAIN2	Q5VXU1	91	158	91	92	Site	Note=Breakpoint for interstitial deletion to form SUSP1-NKAIN2
NLGN4X	Q8N0W4	208	270	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	157	208	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	208	270	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	157	208	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	228	290	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	157	177	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	208	270	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	157	208	42	816	Chain	ID=PRO_0000008648;Note=Neuroligin-4%2C X-linked
NLGN4X	Q8N0W4	208	270	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	157	208	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	208	270	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	157	208	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	228	290	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	157	177	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	208	270	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	157	208	42	676	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NLGN4X	Q8N0W4	157	208	157	157	Alternative sequence	ID=VSP_013270;Note=In isoform 2. D->DGANTKKNADDITSNDRGEDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
NLGN4X	Q8N0W4	157	208	157	157	Alternative sequence	ID=VSP_013270;Note=In isoform 2. D->DGANTKKNADDITSNDRGEDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
NLGN4X	Q8N0W4	157	177	157	157	Alternative sequence	ID=VSP_013270;Note=In isoform 2. D->DGANTKKNADDITSNDRGEDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
NLGN4X	Q8N0W4	157	208	157	157	Alternative sequence	ID=VSP_013270;Note=In isoform 2. D->DGANTKKNADDITSNDRGEDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
NLGN4X	Q8N0W4	208	270	214	214	Natural variant	ID=VAR_036576;Note=In a colorectal cancer sample%3B somatic mutation. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs749477993,PMID:16959974
NLGN4X	Q8N0W4	208	270	214	214	Natural variant	ID=VAR_036576;Note=In a colorectal cancer sample%3B somatic mutation. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs749477993,PMID:16959974
NLGN4X	Q8N0W4	208	270	214	214	Natural variant	ID=VAR_036576;Note=In a colorectal cancer sample%3B somatic mutation. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs749477993,PMID:16959974
NLGN4X	Q8N0W4	157	208	166	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	166	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	177	166	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	166	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	177	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	182	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	182	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	182	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	188	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	188	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	188	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	197	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	197	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	197	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	157	208	206	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	238	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	238	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	238	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	238	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	243	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	243	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	243	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	243	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	255	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	255	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	255	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	255	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	208	270	270	272	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XB6
NLGN4X	Q8N0W4	208	270	270	272	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XB6
NLGN4X	Q8N0W4	228	290	270	272	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XB6
NLGN4X	Q8N0W4	208	270	270	272	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XB6
NLGN4X	Q8N0W4	228	290	274	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	283	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NLGN4X	Q8N0W4	228	290	286	288	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BE8
NOLC1	Q14978	329	366	1	699	Chain	ID=PRO_0000096942;Note=Nucleolar and coiled-body phosphoprotein 1
NOLC1	Q14978	329	366	325	336	Repeat	Note=Acidic serine cluster 6
NOLC1	Q14978	329	366	363	375	Repeat	Note=Acidic serine cluster 7
NOLC1	Q14978	329	366	84	566	Region	Note=11 X 12 AA approximate repeats of an acidic serine cluster
NOLC1	Q14978	329	366	204	382	Region	Note=Interaction with RPA194
NOLC1	Q14978	329	366	362	362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NOLC1	Q14978	329	366	363	363	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NOLC1	Q14978	329	366	366	366	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NOLC1	Q14978	329	366	342	342	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
NOLC1	Q14978	329	366	347	347	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
NRG3	P56975	528	551	1	720	Chain	ID=PRO_0000019481;Note=Pro-neuregulin-3%2C membrane-bound isoform
NRG3	P56975	528	551	382	720	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRG3	P56975	528	551	529	552	Alternative sequence	ID=VSP_035752;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PROC	P04070	87	133	43	461	Chain	ID=PRO_0000028108;Note=Vitamin K-dependent protein C
PROC	P04070	133	178	43	461	Chain	ID=PRO_0000028108;Note=Vitamin K-dependent protein C
PROC	P04070	87	133	43	197	Chain	ID=PRO_0000028109;Note=Vitamin K-dependent protein C light chain
PROC	P04070	133	178	43	197	Chain	ID=PRO_0000028109;Note=Vitamin K-dependent protein C light chain
PROC	P04070	87	133	43	88	Domain	Note=Gla;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00463
PROC	P04070	87	133	97	132	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
PROC	P04070	133	178	136	176	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
PROC	P04070	87	133	113	113	Modified residue	Note=(3R)-3-hydroxyaspartate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2991887;Dbxref=PMID:2991887
PROC	P04070	133	178	139	139	Glycosylation	Note=N-linked (GlcNAc...) asparagine
PROC	P04070	87	133	92	111	Disulfide bond	.
PROC	P04070	87	133	101	106	Disulfide bond	.
PROC	P04070	87	133	105	120	Disulfide bond	.
PROC	P04070	87	133	122	131	Disulfide bond	.
PROC	P04070	133	178	140	151	Disulfide bond	.
PROC	P04070	133	178	147	160	Disulfide bond	.
PROC	P04070	133	178	162	175	Disulfide bond	.
PROC	P04070	87	133	133	133	Alternative sequence	ID=VSP_054394;Note=In isoform 2. R->RGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PROC	P04070	133	178	133	133	Alternative sequence	ID=VSP_054394;Note=In isoform 2. R->RGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PROC	P04070	87	133	89	89	Natural variant	ID=VAR_006647;Note=In patients with PROC deficiency. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7605880;Dbxref=PMID:7605880
PROC	P04070	87	133	106	106	Natural variant	ID=VAR_074297;Note=In patients with PROC deficiency. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22545135;Dbxref=dbSNP:rs199469479,PMID:22545135
PROC	P04070	87	133	108	108	Natural variant	ID=VAR_006648;Note=In patients with PROC deficiency%3B La Jolla-1. H->N;Dbxref=dbSNP:rs200234655
PROC	P04070	87	133	109	109	Natural variant	ID=VAR_006649;Note=In patients with PROC deficiency. G->R
PROC	P04070	87	133	114	118	Natural variant	ID=VAR_006650;Note=In patients with PROC deficiency. Missing
PROC	P04070	87	133	114	114	Natural variant	ID=VAR_006651;Note=In THPH3. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7792728;Dbxref=dbSNP:rs374476971,PMID:7792728
PROC	P04070	87	133	118	118	Natural variant	ID=VAR_074298;Note=In patients with PROC deficiency%3B requires 2 nucleotide substitutions. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22545135;Dbxref=PMID:22545135
PROC	P04070	87	133	118	118	Natural variant	ID=VAR_006652;Note=In patients with PROC deficiency. F->L
PROC	P04070	87	133	119	124	Natural variant	ID=VAR_006653;Note=In patients with PROC deficiency%3B St Louis-2. Missing
PROC	P04070	87	133	120	125	Natural variant	ID=VAR_006654;Note=In patients with PROC deficiency%3B St Louis-3. Missing
PROC	P04070	133	178	144	145	Natural variant	ID=VAR_006655;Note=In THPH4%3B neonatal purpura fulminans. NG->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7841323;Dbxref=PMID:7841323
PROC	P04070	133	178	145	145	Natural variant	ID=VAR_006656;Note=In THPH3. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8292730;Dbxref=PMID:8292730
PROC	P04070	133	178	147	147	Natural variant	ID=VAR_006657;Note=In patients with PROC deficiency. C->Y
PROC	P04070	133	178	149	149	Natural variant	ID=VAR_006658;Note=In patients with PROC deficiency. H->P;Dbxref=dbSNP:rs121918159
PROC	P04070	133	178	161	161	Natural variant	ID=VAR_006659;Note=In patients with PROC deficiency. S->R
PROC	P04070	133	178	163	163	Natural variant	ID=VAR_073146;Note=In THPH4%3B drastically reduced secretion%3B colocalizes with 26S proteasome. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25618265;Dbxref=PMID:25618265
PROC	P04070	133	178	163	163	Natural variant	ID=VAR_073147;Note=In THPH3%3B drastically reduced secretion%3B colocalizes with 26S proteasome. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25618265;Dbxref=PMID:25618265
PROC	P04070	133	178	175	175	Natural variant	ID=VAR_074299;Note=In patients with PROC deficiency. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22545135;Dbxref=dbSNP:rs199469474,PMID:22545135
PROC	P04070	133	178	178	178	Natural variant	ID=VAR_006660;Note=In THPH4%3B Clamart. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7878626;Dbxref=PMID:7878626
PROC	P04070	87	133	106	106	Sequence conflict	Note=C->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROC	P04070	87	133	100	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	87	133	104	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	87	133	108	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	87	133	120	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	87	133	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	133	178	137	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	133	178	143	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	133	178	148	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	133	178	155	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	133	178	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROC	P04070	133	178	175	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AUT
PROX1	Q92786	611	676	1	737	Chain	ID=PRO_0000208880;Note=Prospero homeobox protein 1
PROX1	Q92786	611	676	1	737	Chain	ID=PRO_0000208880;Note=Prospero homeobox protein 1
PROX1	Q92786	611	676	1	737	Chain	ID=PRO_0000208880;Note=Prospero homeobox protein 1
PROX1	Q92786	611	676	1	737	Chain	ID=PRO_0000208880;Note=Prospero homeobox protein 1
PROX1	Q92786	611	676	577	635	Domain	Note=Prospero-type homeo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	635	Domain	Note=Prospero-type homeo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	635	Domain	Note=Prospero-type homeo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	635	Domain	Note=Prospero-type homeo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	636	735	Domain	Note=Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	636	735	Domain	Note=Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	636	735	Domain	Note=Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	636	735	Domain	Note=Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	735	Region	Note=Homeo-Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	735	Region	Note=Homeo-Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	735	Region	Note=Homeo-Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	577	735	Region	Note=Homeo-Prospero;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01162
PROX1	Q92786	611	676	614	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	614	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	614	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	614	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	650	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	650	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	650	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	650	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	653	656	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	653	656	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	653	656	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	653	656	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	660	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	660	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	660	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
PROX1	Q92786	611	676	660	669	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LMD
NUP205	Q92621	688	758	2	2012	Chain	ID=PRO_0000204859;Note=Nuclear pore complex protein Nup205
DHX38	Q92620	170	205	2	1227	Chain	ID=PRO_0000055147;Note=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
DHX38	Q92620	1127	1159	2	1227	Chain	ID=PRO_0000055147;Note=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
DHX38	Q92620	170	205	199	199	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
DHX38	Q92620	170	205	99	786	Alternative sequence	ID=VSP_056045;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSD1	Q96L73	1499	1547	1	2696	Chain	ID=PRO_0000186070;Note=Histone-lysine N-methyltransferase%2C H3 lysine-36 and H4 lysine-20 specific
NSD1	Q96L73	1655	1715	1	2696	Chain	ID=PRO_0000186070;Note=Histone-lysine N-methyltransferase%2C H3 lysine-36 and H4 lysine-20 specific
NSD1	Q96L73	1874	1964	1	2696	Chain	ID=PRO_0000186070;Note=Histone-lysine N-methyltransferase%2C H3 lysine-36 and H4 lysine-20 specific
NSD1	Q96L73	1964	2003	1	2696	Chain	ID=PRO_0000186070;Note=Histone-lysine N-methyltransferase%2C H3 lysine-36 and H4 lysine-20 specific
NSD1	Q96L73	1874	1964	1890	1940	Domain	Note=AWS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00562
NSD1	Q96L73	1874	1964	1942	2059	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
NSD1	Q96L73	1964	2003	1942	2059	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
NSD1	Q96L73	1499	1547	1543	1589	Zinc finger	Note=PHD-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
NSD1	Q96L73	1655	1715	1707	1751	Zinc finger	Note=PHD-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
NSD1	Q96L73	1874	1964	1952	1954	Region	Note=S-adenosyl-L-methionine binding
NSD1	Q96L73	1964	2003	1994	1997	Region	Note=S-adenosyl-L-methionine binding
NSD1	Q96L73	1499	1547	1510	1510	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88491
NSD1	Q96L73	1655	1715	1674	1674	Natural variant	ID=VAR_015782;Note=In SOTOS1. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12464997;Dbxref=PMID:12464997
NSD1	Q96L73	1655	1715	1687	1687	Natural variant	ID=VAR_015783;Note=In SOTOS1. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12807965;Dbxref=PMID:12807965
NSD1	Q96L73	1874	1964	1925	1925	Natural variant	ID=VAR_015785;Note=In SOTOS1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12464997;Dbxref=PMID:12464997
NSD1	Q96L73	1874	1964	1955	1955	Natural variant	ID=VAR_015786;Note=In SOTOS1. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12807965;Dbxref=PMID:12807965
NSD1	Q96L73	1964	2003	1984	1984	Natural variant	ID=VAR_015787;Note=In SOTOS1%3B loss of enzyme activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12807965,ECO:0000269|PubMed:21196496;Dbxref=dbSNP:rs587784169,PMID:12807965,PMID:21196496
NSD1	Q96L73	1964	2003	1997	1997	Natural variant	ID=VAR_015788;Note=In SOTOS1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12807965;Dbxref=dbSNP:rs797045825,PMID:12807965
NSD1	Q96L73	1874	1964	1914	1914	Mutagenesis	Note=Reduced enzyme activity. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21196496;Dbxref=PMID:21196496
NSD1	Q96L73	1874	1964	1952	1952	Mutagenesis	Note=Nearly abolished enzyme activity. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21196496;Dbxref=PMID:21196496
NSD1	Q96L73	1874	1964	1959	1960	Sequence conflict	Note=KT->QE;Ontology_term=ECO:0000305;evidence=ECO:0000305
NSD1	Q96L73	1874	1964	1963	1963	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NSD1	Q96L73	1964	2003	1982	1982	Sequence conflict	Note=R->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
NSD1	Q96L73	1964	2003	1986	1991	Sequence conflict	Note=RYAQEH->KHAHEN;Ontology_term=ECO:0000305;evidence=ECO:0000305
NSD1	Q96L73	1964	2003	1995	1995	Sequence conflict	Note=N->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
NSD1	Q96L73	1964	2003	2001	2001	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NSD1	Q96L73	1874	1964	1889	1891	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1901	1903	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1912	1915	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1922	1924	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1928	1930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1935	1938	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1944	1948	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1874	1964	1950	1960	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1964	2003	1967	1970	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1964	2003	1973	1976	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1964	2003	1978	1990	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NSD1	Q96L73	1964	2003	1998	2002	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OOI
NUTF2	P61970	33	57	1	127	Chain	ID=PRO_0000194775;Note=Nuclear transport factor 2
NUTF2	P61970	57	90	1	127	Chain	ID=PRO_0000194775;Note=Nuclear transport factor 2
NUTF2	P61970	33	57	1	127	Chain	ID=PRO_0000194775;Note=Nuclear transport factor 2
NUTF2	P61970	57	90	1	127	Chain	ID=PRO_0000194775;Note=Nuclear transport factor 2
NUTF2	P61970	33	57	1	127	Chain	ID=PRO_0000194775;Note=Nuclear transport factor 2
NUTF2	P61970	57	90	1	127	Chain	ID=PRO_0000194775;Note=Nuclear transport factor 2
NUTF2	P61970	33	57	10	121	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NUTF2	P61970	57	90	10	121	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NUTF2	P61970	33	57	10	121	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NUTF2	P61970	57	90	10	121	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NUTF2	P61970	33	57	10	121	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NUTF2	P61970	57	90	10	121	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NUTF2	P61970	33	57	42	42	Mutagenesis	Note=No effect on localization to the nucleoplasm. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679025;Dbxref=PMID:10679025
NUTF2	P61970	33	57	42	42	Mutagenesis	Note=No effect on localization to the nucleoplasm. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679025;Dbxref=PMID:10679025
NUTF2	P61970	33	57	42	42	Mutagenesis	Note=No effect on localization to the nucleoplasm. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679025;Dbxref=PMID:10679025
NUTF2	P61970	33	57	33	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	33	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	33	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	44	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	44	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	44	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	49	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	49	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	49	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	49	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	33	57	49	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	49	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	62	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	62	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	62	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	81	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	81	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUTF2	P61970	57	90	81	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GY5
NUP214	P35658	1052	1106	2	2090	Chain	ID=PRO_0000204861;Note=Nuclear pore complex protein Nup214
NUP214	P35658	1916	1967	2	2090	Chain	ID=PRO_0000204861;Note=Nuclear pore complex protein Nup214
NUP214	P35658	1052	1106	481	2076	Region	Note=11 X 5 AA approximate repeats
NUP214	P35658	1916	1967	481	2076	Region	Note=11 X 5 AA approximate repeats
NUP214	P35658	1916	1967	1409	2084	Region	Note=18 X 4 AA approximate repeats
NUP214	P35658	1916	1967	1427	2085	Region	Note=11 X 3 AA approximate repeats
NUP214	P35658	1052	1106	680	1209	Coiled coil	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19208808;Dbxref=PMID:19208808
NUP214	P35658	1916	1967	1213	2090	Compositional bias	Note=Pro/Ser/Thr-rich
NUP214	P35658	1052	1106	1056	1056	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP214	P35658	1052	1106	1081	1081	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
NUP214	P35658	1916	1967	1963	1963	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NUP214	P35658	1052	1106	1091	1092	Sequence conflict	Note=AA->QL;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP214	P35658	1916	1967	1925	1929	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
NUP214	P35658	1916	1967	1937	1941	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
NUP214	P35658	1916	1967	1943	1945	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
PRPF19	Q9UMS4	380	437	2	504	Chain	ID=PRO_0000051145;Note=Pre-mRNA-processing factor 19
PRPF19	Q9UMS4	380	437	348	387	Repeat	Note=WD 4
PRPF19	Q9UMS4	380	437	390	429	Repeat	Note=WD 5
PRPF19	Q9UMS4	380	437	433	472	Repeat	Note=WD 6
PRPF19	Q9UMS4	380	437	405	405	Mutagenesis	Note=Loss of interaction with the RPA complex and loss of recruitment to sites of DNA damage. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24332808;Dbxref=PMID:24332808
PRPF19	Q9UMS4	380	437	379	382	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
PRPF19	Q9UMS4	380	437	383	388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
PRPF19	Q9UMS4	380	437	395	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
PRPF19	Q9UMS4	380	437	404	411	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
PRPF19	Q9UMS4	380	437	414	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
PRPF19	Q9UMS4	380	437	421	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
PRPF19	Q9UMS4	380	437	425	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG8
ORC6	Q9Y5N6	120	149	1	252	Chain	ID=PRO_0000127097;Note=Origin recognition complex subunit 6
ORC6	Q9Y5N6	187	210	1	252	Chain	ID=PRO_0000127097;Note=Origin recognition complex subunit 6
ORC6	Q9Y5N6	187	210	195	195	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:23186163
ORC6	Q9Y5N6	187	210	210	210	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ORC6	Q9Y5N6	120	149	138	138	Natural variant	ID=VAR_029284;Note=P->Q;Dbxref=dbSNP:rs3218745
ORC6	Q9Y5N6	120	149	129	129	Mutagenesis	Note=Abolished DNA binding. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21502537;Dbxref=PMID:21502537
ORC6	Q9Y5N6	120	149	137	137	Mutagenesis	Note=Abolished DNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21502537;Dbxref=PMID:21502537
ORC6	Q9Y5N6	120	149	111	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M03
ORC6	Q9Y5N6	120	149	127	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M03
ORC6	Q9Y5N6	120	149	138	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3M03
OSCP1	Q8WVF1	37	47	1	389	Chain	ID=PRO_0000251965;Note=Protein OSCP1
OSCP1	Q8WVF1	37	47	38	47	Alternative sequence	ID=VSP_039475;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12819961,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16006562;Dbxref=PMID:12819961,PMID:15489334,PMID:16006562
NT5DC3	Q86UY8	367	396	1	548	Chain	ID=PRO_0000326247;Note=5'-nucleotidase domain-containing protein 3
NT5DC3	Q86UY8	367	396	389	389	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUP188	Q5SRE5	371	401	2	1749	Chain	ID=PRO_0000299172;Note=Nucleoporin NUP188 homolog
NUP188	Q5SRE5	401	423	2	1749	Chain	ID=PRO_0000299172;Note=Nucleoporin NUP188 homolog
NUP188	Q5SRE5	505	556	2	1749	Chain	ID=PRO_0000299172;Note=Nucleoporin NUP188 homolog
NUP188	Q5SRE5	755	797	2	1749	Chain	ID=PRO_0000299172;Note=Nucleoporin NUP188 homolog
NUP188	Q5SRE5	1117	1143	2	1749	Chain	ID=PRO_0000299172;Note=Nucleoporin NUP188 homolog
NUP188	Q5SRE5	1432	1478	2	1749	Chain	ID=PRO_0000299172;Note=Nucleoporin NUP188 homolog
NUP188	Q5SRE5	755	797	773	773	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDT22	Q9BRQ3	160	193	1	303	Chain	ID=PRO_0000263731;Note=Uridine diphosphate glucose pyrophosphatase
NUDT22	Q9BRQ3	160	193	118	285	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT22	Q9BRQ3	160	193	175	196	Motif	Note=Nudix box;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29413322;Dbxref=PMID:29413322
NUDT22	Q9BRQ3	160	193	189	189	Metal binding	Note=Magnesium;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29413322;Dbxref=PMID:29413322
NUDT22	Q9BRQ3	160	193	193	193	Metal binding	Note=Magnesium;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29413322;Dbxref=PMID:29413322
NUDT22	Q9BRQ3	160	193	160	193	Alternative sequence	ID=VSP_053790;Note=In isoform 3. QALCPGGSPQHQDLAGQLVVHELFSSVLQEICDE->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDT22	Q9BRQ3	160	193	161	303	Alternative sequence	ID=VSP_021884;Note=In isoform 2. ALCPGGSPQHQDLAGQLVVHELFSSVLQEICDEVNLPLLTLSQPLLLGIARNETSAGRASAEFYVQCSLTSEQVRKHYLSGGPEAHESTGIFFVETQNVQRLLETEMWAELCPSAKGAIILYNRVQGSPTGAALGSPALLPPL->VRFQAGHKDPDSSRELQLSTLPILPALVSPSLKGKLAWYFSGSLLRAVHLPPH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
NUDT22	Q9BRQ3	160	193	189	189	Mutagenesis	Note=Abolishes enzyme activity with UDP-galactose. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29413322;Dbxref=PMID:29413322
NUDT22	Q9BRQ3	160	193	193	193	Mutagenesis	Note=Abolishes enzyme activity with UDP-galactose. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29413322;Dbxref=PMID:29413322
NUDT22	Q9BRQ3	160	193	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LOR
NUDT22	Q9BRQ3	160	193	165	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LOU
NUDT22	Q9BRQ3	160	193	171	173	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LF9
NUDT22	Q9BRQ3	160	193	174	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LF9
NUDCD1	Q96RS6	391	433	1	583	Chain	ID=PRO_0000307704;Note=NudC domain-containing protein 1
NUDCD1	Q96RS6	91	153	1	583	Chain	ID=PRO_0000307704;Note=NudC domain-containing protein 1
NUDCD1	Q96RS6	91	153	64	91	Alternative sequence	ID=VSP_052560;Note=In isoform 3. YLHCDSWYQDSVYYIDTLGRIMNLTVML->Q;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
NUDCD1	Q96RS6	391	433	394	394	Natural variant	ID=VAR_036634;Note=N->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs34660136,PMID:15489334,PMID:17974005
NUDCD1	Q96RS6	391	433	426	426	Natural variant	ID=VAR_036635;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs11550169,PMID:15489334,PMID:17974005
NUDCD1	Q96RS6	391	433	403	403	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDC	Q9Y266	27	53	1	331	Chain	ID=PRO_0000057990;Note=Nuclear migration protein nudC
NUDC	Q9Y266	121	143	1	331	Chain	ID=PRO_0000057990;Note=Nuclear migration protein nudC
NUDC	Q9Y266	143	182	1	331	Chain	ID=PRO_0000057990;Note=Nuclear migration protein nudC
NUDC	Q9Y266	182	247	1	331	Chain	ID=PRO_0000057990;Note=Nuclear migration protein nudC
NUDC	Q9Y266	143	182	167	258	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
NUDC	Q9Y266	182	247	167	258	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
NUDC	Q9Y266	121	143	60	134	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUDC	Q9Y266	121	143	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUDC	Q9Y266	121	143	139	139	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
NUDC	Q9Y266	143	182	145	145	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:20068231,PMID:23186163
NUDC	Q9Y266	182	247	239	239	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NUDC	Q9Y266	121	143	128	128	Sequence conflict	Note=H->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDC	Q9Y266	143	182	149	149	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDC	Q9Y266	143	182	169	169	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDC	Q9Y266	143	182	173	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	143	182	178	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	178	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	206	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	217	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	228	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	232	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUDC	Q9Y266	182	247	240	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QOR
NUFIP2	Q7Z417	667	678	1	695	Chain	ID=PRO_0000245521;Note=Nuclear fragile X mental retardation-interacting protein 2
NUFIP2	Q7Z417	667	678	93	667	Alternative sequence	ID=VSP_056177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PDHX	O00330	53	80	1	53	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDHX	O00330	53	80	54	501	Chain	ID=PRO_0000020484;Note=Pyruvate dehydrogenase protein X component%2C mitochondrial
PDHX	O00330	341	394	54	501	Chain	ID=PRO_0000020484;Note=Pyruvate dehydrogenase protein X component%2C mitochondrial
PDHX	O00330	53	80	56	132	Domain	Note=Lipoyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066
PDHX	O00330	341	394	394	394	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BKZ9
PDHX	O00330	53	80	2	53	Alternative sequence	ID=VSP_053817;Note=In isoform 3. AASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLR->QSGGAEGSPGAGRTGRGPGSGKAPPAEISSGAPDFPG;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDHX	O00330	341	394	115	341	Alternative sequence	ID=VSP_045271;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDHX	O00330	341	394	370	370	Natural variant	ID=VAR_046621;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17850649,PMID:15489334
PDHX	O00330	341	394	344	344	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDHX	O00330	53	80	57	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNC
PDHX	O00330	53	80	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNC
PDHX	O00330	53	80	73	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNC
NOC3L	Q8WTT2	232	286	1	800	Chain	ID=PRO_0000173474;Note=Nucleolar complex protein 3 homolog
NOP58	Q9Y2X3	166	211	1	529	Chain	ID=PRO_0000219023;Note=Nucleolar protein 58
NOP58	Q9Y2X3	166	211	202	221	Sequence conflict	Note=LTYCKCLQKVGDRKNYASAK->YHTASVYRKLAIGRLCLCQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC17A2	O00624	256	310	1	439	Chain	ID=PRO_0000220940;Note=Sodium-dependent phosphate transport protein 3
SLC17A2	O00624	256	310	273	293	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A3	O00476	199	253	1	420	Chain	ID=PRO_0000351138;Note=Sodium-dependent phosphate transport protein 4
SLC17A3	O00476	199	253	1	420	Chain	ID=PRO_0000351138;Note=Sodium-dependent phosphate transport protein 4
SLC17A3	O00476	199	253	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A3	O00476	199	253	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A3	O00476	199	253	201	201	Natural variant	ID=VAR_034700;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15505377;Dbxref=dbSNP:rs56027330,PMID:15505377
SLC17A3	O00476	199	253	201	201	Natural variant	ID=VAR_034700;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15505377;Dbxref=dbSNP:rs56027330,PMID:15505377
SLC17A3	O00476	199	253	226	226	Natural variant	ID=VAR_068681;Note=Found in a patient with hyperuricemia%3B decreased expression of isoform 2 at the cell membrane%3B results in highly reduced urate efflux. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20810651;Dbxref=dbSNP:rs387907256,PMID:20810651
SLC17A3	O00476	199	253	226	226	Natural variant	ID=VAR_068681;Note=Found in a patient with hyperuricemia%3B decreased expression of isoform 2 at the cell membrane%3B results in highly reduced urate efflux. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20810651;Dbxref=dbSNP:rs387907256,PMID:20810651
NSDHL	Q15738	36	89	1	373	Chain	ID=PRO_0000087799;Note=Sterol-4-alpha-carboxylate 3-dehydrogenase%2C decarboxylating
NSDHL	Q15738	89	138	1	373	Chain	ID=PRO_0000087799;Note=Sterol-4-alpha-carboxylate 3-dehydrogenase%2C decarboxylating
NSDHL	Q15738	36	89	1	373	Chain	ID=PRO_0000087799;Note=Sterol-4-alpha-carboxylate 3-dehydrogenase%2C decarboxylating
NSDHL	Q15738	89	138	1	373	Chain	ID=PRO_0000087799;Note=Sterol-4-alpha-carboxylate 3-dehydrogenase%2C decarboxylating
NSDHL	Q15738	89	138	105	105	Natural variant	ID=VAR_010207;Note=In CHILD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10710235;Dbxref=dbSNP:rs104894909,PMID:10710235
NSDHL	Q15738	89	138	105	105	Natural variant	ID=VAR_010207;Note=In CHILD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10710235;Dbxref=dbSNP:rs104894909,PMID:10710235
RASA1	P20936	868	896	1	1047	Chain	ID=PRO_0000056636;Note=Ras GTPase-activating protein 1
RASA1	P20936	868	896	748	942	Domain	Note=Ras-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00167
RASA1	P20936	868	896	540	1047	Alternative sequence	ID=VSP_057435;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
RASA1	P20936	868	896	868	884	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WER
RASA1	P20936	868	896	891	900	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WER
RABGAP1L	B7ZAP0	137	203	1	253	Chain	ID=PRO_0000417613;Note=Rab GTPase-activating protein 1-like%2C isoform 10
RABGAP1L	B7ZAP0	137	203	8	222	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAB3GAP2	Q9H2M9	1289	1342	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	1215	1289	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	1087	1112	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	1075	1087	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	237	270	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	170	204	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	129	144	1	1393	Chain	ID=PRO_0000191662;Note=Rab3 GTPase-activating protein non-catalytic subunit
RAB3GAP2	Q9H2M9	1289	1342	207	1393	Alternative sequence	ID=VSP_013312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB3GAP2	Q9H2M9	1215	1289	207	1393	Alternative sequence	ID=VSP_013312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB3GAP2	Q9H2M9	1087	1112	207	1393	Alternative sequence	ID=VSP_013312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB3GAP2	Q9H2M9	1075	1087	207	1393	Alternative sequence	ID=VSP_013312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB3GAP2	Q9H2M9	237	270	207	1393	Alternative sequence	ID=VSP_013312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB3GAP2	Q9H2M9	1087	1112	1092	1092	Natural variant	ID=VAR_021589;Note=S->T;Dbxref=dbSNP:rs2289189
RNF214	Q8ND24	615	650	2	703	Chain	ID=PRO_0000280546;Note=RING finger protein 214
RNF214	Q8ND24	615	650	2	703	Chain	ID=PRO_0000280546;Note=RING finger protein 214
RNF215	Q9Y6U7	248	288	1	377	Chain	ID=PRO_0000287534;Note=RING finger protein 215
RNF215	Q9Y6U7	143	167	1	377	Chain	ID=PRO_0000287534;Note=RING finger protein 215
RNF215	Q9Y6U7	248	288	44	250	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF215	Q9Y6U7	143	167	44	250	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF215	Q9Y6U7	248	288	251	271	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF215	Q9Y6U7	248	288	272	377	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF217	Q8TC41	494	518	1	542	Chain	ID=PRO_0000084128;Note=Probable E3 ubiquitin-protein ligase RNF217
RNF217	Q8TC41	494	518	503	523	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RALBP1	Q15311	449	485	2	655	Chain	ID=PRO_0000056733;Note=RalA-binding protein 1
RALBP1	Q15311	449	485	2	655	Chain	ID=PRO_0000056733;Note=RalA-binding protein 1
RALBP1	Q15311	449	485	403	499	Region	Note=Interaction with RalA
RALBP1	Q15311	449	485	403	499	Region	Note=Interaction with RalA
RALBP1	Q15311	449	485	461	461	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RALBP1	Q15311	449	485	461	461	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RALBP1	Q15311	449	485	463	463	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:23186163,PMID:24275569
RALBP1	Q15311	449	485	463	463	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:23186163,PMID:24275569
RBMS1	P29558	354	381	1	406	Chain	ID=PRO_0000081798;Note=RNA-binding motif%2C single-stranded-interacting protein 1
RBMS1	P29558	354	381	39	406	Alternative sequence	ID=VSP_037791;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7838710;Dbxref=PMID:7838710
RDH10	Q8IZV5	175	208	1	341	Chain	ID=PRO_0000307682;Note=Retinol dehydrogenase 10
RDH10	Q8IZV5	175	208	197	197	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RDH12	Q96NR8	149	219	1	316	Chain	ID=PRO_0000054766;Note=Retinol dehydrogenase 12
RDH12	Q96NR8	149	219	1	316	Chain	ID=PRO_0000054766;Note=Retinol dehydrogenase 12
RDH12	Q96NR8	149	219	200	200	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
RDH12	Q96NR8	149	219	200	200	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
RDH12	Q96NR8	149	219	175	175	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RDH12	Q96NR8	149	219	175	175	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RDH12	Q96NR8	149	219	151	151	Natural variant	ID=VAR_020861;Note=In LCA13%3B exhibits a profound loss of catalytic activity. H->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15322982,ECO:0000269|PubMed:16269441;Dbxref=dbSNP:rs104894475,PMID:15322982,PMID:16269441
RDH12	Q96NR8	149	219	151	151	Natural variant	ID=VAR_020861;Note=In LCA13%3B exhibits a profound loss of catalytic activity. H->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15322982,ECO:0000269|PubMed:16269441;Dbxref=dbSNP:rs104894475,PMID:15322982,PMID:16269441
RDH12	Q96NR8	149	219	151	151	Natural variant	ID=VAR_020862;Note=In LCA13. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15322982;Dbxref=dbSNP:rs104894475,PMID:15322982
RDH12	Q96NR8	149	219	151	151	Natural variant	ID=VAR_020862;Note=In LCA13. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15322982;Dbxref=dbSNP:rs104894475,PMID:15322982
RDH12	Q96NR8	149	219	155	155	Natural variant	ID=VAR_064171;Note=In retinal dystrophy%3B exhibits a profound loss of catalytic activity. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=dbSNP:rs121434337,PMID:16269441
RDH12	Q96NR8	149	219	155	155	Natural variant	ID=VAR_064171;Note=In retinal dystrophy%3B exhibits a profound loss of catalytic activity. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=dbSNP:rs121434337,PMID:16269441
RDH12	Q96NR8	149	219	161	161	Natural variant	ID=VAR_028281;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16269441,ECO:0000269|PubMed:21602930;Dbxref=dbSNP:rs17852293,PMID:14702039,PMID:16269441,PMID:21602930
RDH12	Q96NR8	149	219	161	161	Natural variant	ID=VAR_028281;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16269441,ECO:0000269|PubMed:21602930;Dbxref=dbSNP:rs17852293,PMID:14702039,PMID:16269441,PMID:21602930
RDH12	Q96NR8	149	219	175	175	Natural variant	ID=VAR_020863;Note=In LCA13. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15322982;Dbxref=dbSNP:rs104894472,PMID:15322982
RDH12	Q96NR8	149	219	175	175	Natural variant	ID=VAR_020863;Note=In LCA13. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15322982;Dbxref=dbSNP:rs104894472,PMID:15322982
RDH12	Q96NR8	149	219	193	193	Natural variant	ID=VAR_064172;Note=In retinal dystrophy%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=dbSNP:rs148629905,PMID:16269441
RDH12	Q96NR8	149	219	193	193	Natural variant	ID=VAR_064172;Note=In retinal dystrophy%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=dbSNP:rs148629905,PMID:16269441
RDH12	Q96NR8	149	219	206	206	Natural variant	ID=VAR_064173;Note=In retinal dystrophy%3B exhibits a profound loss of catalytic activity. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=PMID:16269441
RDH12	Q96NR8	149	219	206	206	Natural variant	ID=VAR_064173;Note=In retinal dystrophy%3B exhibits a profound loss of catalytic activity. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=PMID:16269441
RDH12	Q96NR8	149	219	206	206	Natural variant	ID=VAR_064174;Note=In retinal dystrophy%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=PMID:16269441
RDH12	Q96NR8	149	219	206	206	Natural variant	ID=VAR_064174;Note=In retinal dystrophy%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16269441;Dbxref=PMID:16269441
RGN	Q15493	115	187	1	299	Chain	ID=PRO_0000173046;Note=Regucalcin
RGN	Q15493	187	231	1	299	Chain	ID=PRO_0000173046;Note=Regucalcin
RGN	Q15493	115	187	1	299	Chain	ID=PRO_0000173046;Note=Regucalcin
RGN	Q15493	187	231	1	299	Chain	ID=PRO_0000173046;Note=Regucalcin
RGN	Q15493	115	187	1	299	Chain	ID=PRO_0000173046;Note=Regucalcin
RGN	Q15493	187	231	1	299	Chain	ID=PRO_0000173046;Note=Regucalcin
RGN	Q15493	187	231	204	204	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	187	231	204	204	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	187	231	204	204	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	115	187	154	154	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	115	187	154	154	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	115	187	154	154	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	187	231	204	204	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	187	231	204	204	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	187	231	204	204	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23349732;Dbxref=PMID:23349732
RGN	Q15493	115	187	121	121	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RGN	Q15493	115	187	121	121	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RGN	Q15493	115	187	121	121	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RGN	Q15493	115	187	144	144	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64374
RGN	Q15493	115	187	144	144	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64374
RGN	Q15493	115	187	144	144	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64374
RGN	Q15493	115	187	116	187	Alternative sequence	ID=VSP_025456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	187	231	116	187	Alternative sequence	ID=VSP_025456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	115	187	116	187	Alternative sequence	ID=VSP_025456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	187	231	116	187	Alternative sequence	ID=VSP_025456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	115	187	116	187	Alternative sequence	ID=VSP_025456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	187	231	116	187	Alternative sequence	ID=VSP_025456;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	187	231	188	188	Alternative sequence	ID=VSP_025457;Note=In isoform 2. S->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	187	231	188	188	Alternative sequence	ID=VSP_025457;Note=In isoform 2. S->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	187	231	188	188	Alternative sequence	ID=VSP_025457;Note=In isoform 2. S->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGN	Q15493	115	187	154	154	Mutagenesis	Note=Reduces enzyme activity by about 95%25. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20329768;Dbxref=PMID:20329768
RGN	Q15493	115	187	154	154	Mutagenesis	Note=Reduces enzyme activity by about 95%25. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20329768;Dbxref=PMID:20329768
RGN	Q15493	115	187	154	154	Mutagenesis	Note=Reduces enzyme activity by about 95%25. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20329768;Dbxref=PMID:20329768
RGN	Q15493	187	231	204	204	Mutagenesis	Note=Reduces enzyme activity by over 98%25. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20329768;Dbxref=PMID:20329768
RGN	Q15493	187	231	204	204	Mutagenesis	Note=Reduces enzyme activity by over 98%25. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20329768;Dbxref=PMID:20329768
RGN	Q15493	187	231	204	204	Mutagenesis	Note=Reduces enzyme activity by over 98%25. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20329768;Dbxref=PMID:20329768
RGN	Q15493	115	187	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	132	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	132	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	132	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	143	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	143	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	143	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	164	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	164	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	164	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	174	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	174	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	174	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	182	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	182	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	182	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	187	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	187	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	187	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	187	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	115	187	187	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	187	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	198	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	198	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	198	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	202	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	202	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	202	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	214	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	214	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	214	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	220	222	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GNB
RGN	Q15493	187	231	220	222	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GNB
RGN	Q15493	187	231	220	222	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GNB
RGN	Q15493	187	231	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	229	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	229	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RGN	Q15493	187	231	229	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G4E
RABGAP1	Q9Y3P9	636	661	1	1069	Chain	ID=PRO_0000298779;Note=Rab GTPase-activating protein 1
RABGAP1	Q9Y3P9	661	703	1	1069	Chain	ID=PRO_0000298779;Note=Rab GTPase-activating protein 1
RABGAP1	Q9Y3P9	703	751	1	1069	Chain	ID=PRO_0000298779;Note=Rab GTPase-activating protein 1
RABGAP1	Q9Y3P9	939	963	1	1069	Chain	ID=PRO_0000298779;Note=Rab GTPase-activating protein 1
RABGAP1	Q9Y3P9	963	1029	1	1069	Chain	ID=PRO_0000298779;Note=Rab GTPase-activating protein 1
RABGAP1	Q9Y3P9	636	661	566	752	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
RABGAP1	Q9Y3P9	661	703	566	752	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
RABGAP1	Q9Y3P9	703	751	566	752	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
RABGAP1	Q9Y3P9	939	963	798	1047	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABGAP1	Q9Y3P9	963	1029	798	1047	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABGAP1	Q9Y3P9	636	661	649	649	Site	Note=Glutamine finger;Ontology_term=ECO:0000250;evidence=ECO:0000250
RABGAP1	Q9Y3P9	963	1029	996	996	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
RABGAP1	Q9Y3P9	636	661	266	1069	Alternative sequence	ID=VSP_052512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	661	703	266	1069	Alternative sequence	ID=VSP_052512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	703	751	266	1069	Alternative sequence	ID=VSP_052512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	939	963	266	1069	Alternative sequence	ID=VSP_052512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	963	1029	266	1069	Alternative sequence	ID=VSP_052512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	636	661	480	1069	Alternative sequence	ID=VSP_052515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RABGAP1	Q9Y3P9	661	703	480	1069	Alternative sequence	ID=VSP_052515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RABGAP1	Q9Y3P9	703	751	480	1069	Alternative sequence	ID=VSP_052515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RABGAP1	Q9Y3P9	939	963	480	1069	Alternative sequence	ID=VSP_052515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RABGAP1	Q9Y3P9	963	1029	480	1069	Alternative sequence	ID=VSP_052515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RABGAP1	Q9Y3P9	636	661	637	667	Alternative sequence	ID=VSP_052513;Note=In isoform 2. AYSVYDEEIGYCQGQSFLAAVLLLHMPEEQA->VFHVKKKKDSILSGGSTLKLHKKQLQSVICI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	661	703	637	667	Alternative sequence	ID=VSP_052513;Note=In isoform 2. AYSVYDEEIGYCQGQSFLAAVLLLHMPEEQA->VFHVKKKKDSILSGGSTLKLHKKQLQSVICI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	661	703	668	1069	Alternative sequence	ID=VSP_052514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	703	751	668	1069	Alternative sequence	ID=VSP_052514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	939	963	668	1069	Alternative sequence	ID=VSP_052514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	963	1029	668	1069	Alternative sequence	ID=VSP_052514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RABGAP1	Q9Y3P9	636	661	626	641	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	636	661	643	645	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	636	661	651	659	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	661	703	664	675	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	661	703	680	684	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	661	703	686	688	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	661	703	689	705	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	703	751	689	705	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	703	751	707	715	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	703	751	720	722	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	703	751	725	730	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	703	751	731	735	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RABGAP1	Q9Y3P9	703	751	738	751	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NC6
RBPJL	Q9UBG7	206	252	1	517	Chain	ID=PRO_0000208570;Note=Recombining binding protein suppressor of hairless-like protein
RBPJL	Q9UBG7	206	252	221	230	DNA binding	Ontology_term=ECO:0000250;evidence=ECO:0000250
RANBP17	Q9H2T7	141	163	2	1088	Chain	ID=PRO_0000204718;Note=Ran-binding protein 17
RANBP17	Q9H2T7	278	318	2	1088	Chain	ID=PRO_0000204718;Note=Ran-binding protein 17
RANBP17	Q9H2T7	318	367	2	1088	Chain	ID=PRO_0000204718;Note=Ran-binding protein 17
REL	Q04864	307	339	2	619	Chain	ID=PRO_0000205165;Note=Proto-oncogene c-Rel
REL	Q04864	307	339	308	339	Alternative sequence	ID=VSP_055857;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UPF3A	Q9H1J1	140	173	1	476	Chain	ID=PRO_0000215296;Note=Regulator of nonsense transcripts 3A
UPF3A	Q9H1J1	140	173	66	140	Region	Note=Required for interaction with UPF2
UPF3A	Q9H1J1	140	173	1	325	Alternative sequence	ID=VSP_012961;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UPF3A	Q9H1J1	140	173	141	173	Alternative sequence	ID=VSP_012962;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UPF3A	Q9H1J1	140	173	143	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L08
RENBP	P51606	315	359	1	427	Chain	ID=PRO_0000208949;Note=N-acylglucosamine 2-epimerase
RENBP	P51606	315	359	255	427	Alternative sequence	ID=VSP_039023;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RGS22	Q8NE09	1236	1263	1	1264	Chain	ID=PRO_0000271376;Note=Regulator of G-protein signaling 22
RGS22	Q8NE09	1120	1173	1	1264	Chain	ID=PRO_0000271376;Note=Regulator of G-protein signaling 22
RGS22	Q8NE09	1006	1060	1	1264	Chain	ID=PRO_0000271376;Note=Regulator of G-protein signaling 22
RGS22	Q8NE09	930	983	1	1264	Chain	ID=PRO_0000271376;Note=Regulator of G-protein signaling 22
RGS22	Q8NE09	646	688	1	1264	Chain	ID=PRO_0000271376;Note=Regulator of G-protein signaling 22
RGS22	Q8NE09	39	113	1	1264	Chain	ID=PRO_0000271376;Note=Regulator of G-protein signaling 22
RGS22	Q8NE09	930	983	852	980	Domain	Note=RGS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
RGS22	Q8NE09	1120	1173	1021	1145	Domain	Note=RGS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
RGS22	Q8NE09	1006	1060	1021	1145	Domain	Note=RGS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
RGS22	Q8NE09	1120	1173	1142	1174	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RGS22	Q8NE09	1236	1263	505	1264	Alternative sequence	ID=VSP_022306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGS22	Q8NE09	1120	1173	505	1264	Alternative sequence	ID=VSP_022306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGS22	Q8NE09	1006	1060	505	1264	Alternative sequence	ID=VSP_022306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGS22	Q8NE09	930	983	505	1264	Alternative sequence	ID=VSP_022306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGS22	Q8NE09	646	688	505	1264	Alternative sequence	ID=VSP_022306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RGS22	Q8NE09	930	983	943	943	Natural variant	ID=VAR_051798;Note=H->Y;Dbxref=dbSNP:rs3133711
RGS22	Q8NE09	39	113	86	86	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGAP10	A1A4S6	104	128	1	786	Chain	ID=PRO_0000304914;Note=Rho GTPase-activating protein 10
ARHGAP10	A1A4S6	128	162	1	786	Chain	ID=PRO_0000304914;Note=Rho GTPase-activating protein 10
ARHGAP10	A1A4S6	387	409	1	786	Chain	ID=PRO_0000304914;Note=Rho GTPase-activating protein 10
ARHGAP10	A1A4S6	409	434	1	786	Chain	ID=PRO_0000304914;Note=Rho GTPase-activating protein 10
ARHGAP10	A1A4S6	676	726	1	786	Chain	ID=PRO_0000304914;Note=Rho GTPase-activating protein 10
ARHGAP10	A1A4S6	104	128	7	262	Domain	Note=BAR
ARHGAP10	A1A4S6	128	162	7	262	Domain	Note=BAR
ARHGAP10	A1A4S6	387	409	389	574	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP10	A1A4S6	409	434	389	574	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP10	A1A4S6	676	726	684	684	Natural variant	ID=VAR_035114;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11432776;Dbxref=dbSNP:rs2276932,PMID:11432776
ARHGAP10	A1A4S6	676	726	712	712	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHEB	Q15382	111	126	1	181	Chain	ID=PRO_0000082708;Note=GTP-binding protein Rheb
RHEB	Q15382	92	110	1	181	Chain	ID=PRO_0000082708;Note=GTP-binding protein Rheb
RHEB	Q15382	111	126	119	122	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15728574,ECO:0000269|PubMed:22002721;Dbxref=PMID:15728574,PMID:22002721
RHEB	Q15382	111	126	118	118	Sequence conflict	Note=G->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHEB	Q15382	92	110	90	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BSX
RHEB	Q15382	111	126	114	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BSX
RHEB	Q15382	111	126	124	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BSX
ARHGAP1	Q07960	299	342	1	439	Chain	ID=PRO_0000056700;Note=Rho GTPase-activating protein 1
ARHGAP1	Q07960	273	299	1	439	Chain	ID=PRO_0000056700;Note=Rho GTPase-activating protein 1
ARHGAP1	Q07960	106	149	1	439	Chain	ID=PRO_0000056700;Note=Rho GTPase-activating protein 1
ARHGAP1	Q07960	106	149	63	218	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
ARHGAP1	Q07960	299	342	244	431	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP1	Q07960	273	299	244	431	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP1	Q07960	273	299	282	282	Site	Note=Involved in G-protein binding to GAPs;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGAP1	Q07960	273	299	261	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	273	299	274	276	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M6X
ARHGAP1	Q07960	273	299	278	282	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	273	299	287	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	299	342	305	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	299	342	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	299	342	325	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	299	342	332	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	299	342	335	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
ARHGAP1	Q07960	299	342	341	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TX4
RIOK3	O14730	272	337	1	519	Chain	ID=PRO_0000213529;Note=Serine/threonine-protein kinase RIO3
RIOK3	O14730	418	448	1	519	Chain	ID=PRO_0000213529;Note=Serine/threonine-protein kinase RIO3
RIOK3	O14730	448	484	1	519	Chain	ID=PRO_0000213529;Note=Serine/threonine-protein kinase RIO3
RIOK3	O14730	272	337	251	519	Domain	Note=Protein kinase
RIOK3	O14730	418	448	251	519	Domain	Note=Protein kinase
RIOK3	O14730	448	484	251	519	Domain	Note=Protein kinase
RIOK3	O14730	272	337	290	290	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RIOK3	O14730	448	484	449	451	Alternative sequence	ID=VSP_012164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RIOK3	O14730	272	337	336	336	Natural variant	ID=VAR_042355;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35401850,PMID:17344846
RIOK3	O14730	418	448	441	441	Natural variant	ID=VAR_042356;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs33969048,PMID:17344846
RIOK3	O14730	418	448	447	447	Natural variant	ID=VAR_042357;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56282762,PMID:17344846
RIOK3	O14730	272	337	290	290	Mutagenesis	Note=Decreases autophosphorylation (in vitro)%3B abolishes inhibition of TNF-alpha-induced NF-kappaB activation%3B no effect on interaction with IRF3%3B fails to activate IFN-beta promoter and IRF3 phosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19557502,ECO:0000269|PubMed:24807708;Dbxref=PMID:19557502,PMID:24807708
RIOK3	O14730	272	337	325	325	Sequence conflict	Note=I->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
RIPK2	O43353	313	343	1	540	Chain	ID=PRO_0000086608;Note=Receptor-interacting serine/threonine-protein kinase 2
RIPK2	O43353	313	343	313	313	Natural variant	ID=VAR_041047;Note=K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35395048,PMID:17344846
RIPK2	O43353	313	343	313	315	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ES0
REG4	Q9BYZ8	55	101	23	158	Chain	ID=PRO_0000017437;Note=Regenerating islet-derived protein 4
REG4	Q9BYZ8	55	101	23	158	Chain	ID=PRO_0000017437;Note=Regenerating islet-derived protein 4
REG4	Q9BYZ8	55	101	37	155	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG4	Q9BYZ8	55	101	37	155	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG4	Q9BYZ8	55	101	98	103	Region	Note=Carbohydrate-binding
REG4	Q9BYZ8	55	101	98	103	Region	Note=Carbohydrate-binding
REG4	Q9BYZ8	55	101	58	154	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00040,ECO:0000269|PubMed:20692269;Dbxref=PMID:20692269
REG4	Q9BYZ8	55	101	58	154	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00040,ECO:0000269|PubMed:20692269;Dbxref=PMID:20692269
REG4	Q9BYZ8	55	101	56	134	Alternative sequence	ID=VSP_014305;Note=In isoform 2. LECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSS->VRNLLPAWPGLSRAKDQPEPQISFDSGSSVLPGHYEEKPLWLVKWREEGCVFNSFNSVSIAEAGAVCQTLDGLQAHTDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12819006;Dbxref=PMID:12819006
REG4	Q9BYZ8	55	101	56	134	Alternative sequence	ID=VSP_014305;Note=In isoform 2. LECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSS->VRNLLPAWPGLSRAKDQPEPQISFDSGSSVLPGHYEEKPLWLVKWREEGCVFNSFNSVSIAEAGAVCQTLDGLQAHTDT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12819006;Dbxref=PMID:12819006
REG4	Q9BYZ8	55	101	51	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	51	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	73	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	73	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REG4	Q9BYZ8	55	101	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KV3
REV3L	O60673	2822	2868	1	3130	Chain	ID=PRO_0000046468;Note=DNA polymerase zeta catalytic subunit
REV3L	O60673	2822	2868	1	3130	Chain	ID=PRO_0000046468;Note=DNA polymerase zeta catalytic subunit
REV3L	O60673	2822	2868	1	3130	Chain	ID=PRO_0000046468;Note=DNA polymerase zeta catalytic subunit
UPF3B	Q9BZI7	269	282	1	483	Chain	ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B
UPF3B	Q9BZI7	156	193	1	483	Chain	ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B
UPF3B	Q9BZI7	123	156	1	483	Chain	ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B
UPF3B	Q9BZI7	156	193	30	255	Region	Note=Necessary for interaction with UPF2
UPF3B	Q9BZI7	123	156	30	255	Region	Note=Necessary for interaction with UPF2
UPF3B	Q9BZI7	269	282	94	483	Region	Note=Sufficient for association with EJC core
UPF3B	Q9BZI7	156	193	94	483	Region	Note=Sufficient for association with EJC core
UPF3B	Q9BZI7	123	156	94	483	Region	Note=Sufficient for association with EJC core
UPF3B	Q9BZI7	156	193	169	169	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
UPF3B	Q9BZI7	269	282	270	282	Alternative sequence	ID=VSP_012963;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11163187,ECO:0000303|PubMed:15489334;Dbxref=PMID:11163187,PMID:15489334
UPF3B	Q9BZI7	156	193	160	160	Natural variant	ID=VAR_037666;Note=In MRXS14. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17704778;Dbxref=dbSNP:rs122468182,PMID:17704778
UPF3B	Q9BZI7	123	156	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UW4
UPF3B	Q9BZI7	123	156	130	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UW4
REG3G	Q6UW15	65	111	27	175	Chain	ID=PRO_0000017434;Note=Regenerating islet-derived protein 3-gamma 16.5 kDa form
REG3G	Q6UW15	65	111	27	175	Chain	ID=PRO_0000017434;Note=Regenerating islet-derived protein 3-gamma 16.5 kDa form
REG3G	Q6UW15	65	111	38	175	Chain	ID=PRO_0000422752;Note=Regenerating islet-derived protein 3-gamma 15 kDa form
REG3G	Q6UW15	65	111	38	175	Chain	ID=PRO_0000422752;Note=Regenerating islet-derived protein 3-gamma 15 kDa form
REG3G	Q6UW15	65	111	47	172	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3G	Q6UW15	65	111	47	172	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3G	Q6UW15	65	111	68	171	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3G	Q6UW15	65	111	68	171	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3G	Q6UW15	65	111	66	111	Alternative sequence	ID=VSP_045169;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
REG3G	Q6UW15	65	111	66	111	Alternative sequence	ID=VSP_045169;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RFC4	P35249	294	332	1	363	Chain	ID=PRO_0000121757;Note=Replication factor C subunit 4
RFC4	P35249	267	294	1	363	Chain	ID=PRO_0000121757;Note=Replication factor C subunit 4
RFC4	P35249	97	136	1	363	Chain	ID=PRO_0000121757;Note=Replication factor C subunit 4
RFC4	P35249	294	332	1	363	Chain	ID=PRO_0000121757;Note=Replication factor C subunit 4
RFC4	P35249	267	294	1	363	Chain	ID=PRO_0000121757;Note=Replication factor C subunit 4
RFC4	P35249	97	136	1	363	Chain	ID=PRO_0000121757;Note=Replication factor C subunit 4
RFC4	P35249	294	332	269	303	Alternative sequence	ID=VSP_055862;Note=In isoform 2. IPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAA->RVLDILNFFLVGFFVAFRKFSSNKYWVFSKCQVLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFC4	P35249	267	294	269	303	Alternative sequence	ID=VSP_055862;Note=In isoform 2. IPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAA->RVLDILNFFLVGFFVAFRKFSSNKYWVFSKCQVLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFC4	P35249	294	332	269	303	Alternative sequence	ID=VSP_055862;Note=In isoform 2. IPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAA->RVLDILNFFLVGFFVAFRKFSSNKYWVFSKCQVLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFC4	P35249	267	294	269	303	Alternative sequence	ID=VSP_055862;Note=In isoform 2. IPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAA->RVLDILNFFLVGFFVAFRKFSSNKYWVFSKCQVLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFC4	P35249	294	332	304	363	Alternative sequence	ID=VSP_055863;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFC4	P35249	294	332	304	363	Alternative sequence	ID=VSP_055863;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RFC4	P35249	267	294	292	292	Natural variant	ID=VAR_014307;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs2066497
RFC4	P35249	267	294	292	292	Natural variant	ID=VAR_014307;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs2066497
RHBDL1	O75783	132	207	1	438	Chain	ID=PRO_0000206173;Note=Rhomboid-related protein 1
RHBDL1	O75783	132	207	196	216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RIBC1	Q8N443	0	39	1	379	Chain	ID=PRO_0000254093;Note=RIB43A-like with coiled-coils protein 1
RIBC1	Q8N443	66	181	1	379	Chain	ID=PRO_0000254093;Note=RIB43A-like with coiled-coils protein 1
RIBC1	Q8N443	66	181	82	111	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RIBC1	Q8N443	66	181	67	181	Alternative sequence	ID=VSP_044834;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RIBC1	Q8N443	66	181	66	66	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
RALY	Q9UKM9	110	125	2	306	Chain	ID=PRO_0000081746;Note=RNA-binding protein Raly
RALY	Q9UKM9	181	219	2	306	Chain	ID=PRO_0000081746;Note=RNA-binding protein Raly
RALY	Q9UKM9	181	219	183	216	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RALY	Q9UKM9	181	219	191	191	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RALY	Q9UKM9	110	125	110	125	Alternative sequence	ID=VSP_005804;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9376072;Dbxref=PMID:15489334,PMID:9376072
RALY	Q9UKM9	181	219	215	215	Natural variant	ID=VAR_015223;Note=Q->R;Dbxref=dbSNP:rs3180568
RALY	Q9UKM9	181	219	214	215	Sequence conflict	Note=EQ->DE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBBP7	Q16576	366	403	2	425	Chain	ID=PRO_0000051195;Note=Histone-binding protein RBBP7
RBBP7	Q16576	295	321	2	425	Chain	ID=PRO_0000051195;Note=Histone-binding protein RBBP7
RBBP7	Q16576	102	160	2	425	Chain	ID=PRO_0000051195;Note=Histone-binding protein RBBP7
RBBP7	Q16576	102	160	47	122	Repeat	Note=WD 1
RBBP7	Q16576	102	160	128	173	Repeat	Note=WD 2
RBBP7	Q16576	295	321	275	312	Repeat	Note=WD 5
RBBP7	Q16576	366	403	318	369	Repeat	Note=WD 6
RBBP7	Q16576	295	321	318	369	Repeat	Note=WD 6
RBBP7	Q16576	366	403	376	403	Repeat	Note=WD 7
RBBP7	Q16576	102	160	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60973
RBBP7	Q16576	102	160	159	159	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60973
RBBP7	Q16576	102	160	155	155	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBBP7	Q16576	102	160	159	159	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
RBBP7	Q16576	102	160	113	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	102	160	127	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	102	160	138	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	102	160	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	102	160	148	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	102	160	153	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	295	321	295	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	295	321	305	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFV
RBBP7	Q16576	295	321	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	295	321	319	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	366	403	365	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	366	403	376	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	366	403	383	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	366	403	388	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RBBP7	Q16576	366	403	396	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CFS
RNF207	Q6ZRF8	314	337	1	634	Chain	ID=PRO_0000300809;Note=RING finger protein 207
RNF207	Q6ZRF8	314	337	245	634	Alternative sequence	ID=VSP_027864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RNF207	Q6ZRF8	314	337	315	371	Alternative sequence	ID=VSP_028440;Note=In isoform 3. ELMERLQGIVTRPHHLRPIQSSKIASDHRAEFARCLEPLLLLGPRRVAAAASGANTL->AGRGLRPQGADGAPLPLPSRKDVGVTRPKAHAAPVHQHQGAAGGGREHALRRALPPL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF212	Q495C1	82	101	1	297	Chain	ID=PRO_0000274612;Note=Probable E3 SUMO-protein ligase RNF212
RNF212	Q495C1	82	101	91	124	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF212	Q495C1	82	101	83	297	Alternative sequence	ID=VSP_022839;Note=In isoform 4. ILEFQEKHRKRLLAFYREKISRLEESLRKSVLQIEQLQSMRSSQQTAFSTIKSSVSTKPHGCLLPPHSSAPDRLESMEVDLSPSPIRKSEIAAGPARISMISPPQDGRMGPHLTASFCFIPWLTLSKPPVPGECVISRGSPCFCIDVCPHWLLLLAFSSGRHGELTNSKTLPIYAEVQRAVLFPFQQAEGTLDTFRTPAVSVVFPLCQFERKKSF->YLRLSRGCCRLKLCPATSSKEVPRGSTHGSQAAARDPQEHWVSTTRAPRPGCRRSQSQPEAQGNTIQDAPHPLTLLHPSRTLIHTKSPWGQKLLEFIKHVCYHRHQSHRPCAPGWFCQVLQRPGAVSGEKTQQTRPAPPATCLLCLSCLSGFRHGPWRWLAPAWAAQALPSDLVAPLFVSYTVEVSITNAGWSFPAAV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RNF212	Q495C1	82	101	83	297	Alternative sequence	ID=VSP_046301;Note=In isoform 6. ILEFQEKHRKRLLAFYREKISRLEESLRKSVLQIEQLQSMRSSQQTAFSTIKSSVSTKPHGCLLPPHSSAPDRLESMEVDLSPSPIRKSEIAAGPARISMISPPQDGRMGPHLTASFCFIPWLTLSKPPVPGECVISRGSPCFCIDVCPHWLLLLAFSSGRHGELTNSKTLPIYAEVQRAVLFPFQQAEGTLDTFRTPAVSVVFPLCQFERKKSF->YLRLSRGCCRLKLCPATSSKEVPRGSTHGSQAAARDPQEHWVSTTRAPRPGCRRSQSQPEAQGNTIQDAPHPLTLLHPSRTLIHTKSPWGQKLLEFIKHVCYHRHQSHRPCAPGWFCQVLQRPGAVSGEKTQQTRPAPPATCLLCLSCLSGFRHGPWRSQALPSDLVAPLFVSYTVEVSITNAGWSFPAAV;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF216	Q9NWF9	548	565	1	866	Chain	ID=PRO_0000056293;Note=E3 ubiquitin-protein ligase RNF216
RNF216	Q9NWF9	67	348	1	866	Chain	ID=PRO_0000056293;Note=E3 ubiquitin-protein ligase RNF216
RNF216	Q9NWF9	548	565	515	566	Zinc finger	Note=RING-type 1
RNF216	Q9NWF9	67	348	100	100	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RNF216	Q9NWF9	67	348	1	378	Alternative sequence	ID=VSP_012443;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11854271,ECO:0000303|PubMed:15107846;Dbxref=PMID:11854271,PMID:15107846
RNF216	Q9NWF9	67	348	67	67	Alternative sequence	ID=VSP_012444;Note=In isoform 2. E->ETNKPQRSRPNLIKPAAQWQDLKRLGEERPKKSRAAFESDKSSYFSVCNNPLFDSGAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15107846;Dbxref=PMID:15107846
RBM6	P78332	519	544	1	1123	Chain	ID=PRO_0000081760;Note=RNA-binding protein 6
RBM6	P78332	862	894	1	1123	Chain	ID=PRO_0000081760;Note=RNA-binding protein 6
RBM6	P78332	981	1006	1	1123	Chain	ID=PRO_0000081760;Note=RNA-binding protein 6
RBM6	P78332	519	544	456	536	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM6	P78332	862	894	892	895	Compositional bias	Note=Poly-Pro
RBM6	P78332	862	894	891	891	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:24275569
RBM6	P78332	862	894	871	871	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM6	P78332	862	894	879	879	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM6	P78332	862	894	887	887	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM6	P78332	981	1006	991	991	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM6	P78332	519	544	1	522	Alternative sequence	ID=VSP_045202;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBM6	P78332	519	544	496	520	Alternative sequence	ID=VSP_057401;Note=In isoform 3. YDYGYVCVEFSLLEDAIGCMEANQG->NSNDPGQRSYPGVCIKPGFLVLQTM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBM6	P78332	519	544	521	1123	Alternative sequence	ID=VSP_057402;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBM6	P78332	862	894	521	1123	Alternative sequence	ID=VSP_057402;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBM6	P78332	981	1006	521	1123	Alternative sequence	ID=VSP_057402;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAD21L1	Q9H4I0	247	285	1	556	Chain	ID=PRO_0000321921;Note=Double-strand-break repair protein rad21-like protein 1
PRR14L	Q5THK1	2036	2059	1	2151	Chain	ID=PRO_0000295739;Note=Protein PRR14L
PRR14L	Q5THK1	1919	1942	1	2151	Chain	ID=PRO_0000295739;Note=Protein PRR14L
PRR14L	Q5THK1	2036	2059	1240	2151	Alternative sequence	ID=VSP_027047;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRR14L	Q5THK1	1919	1942	1240	2151	Alternative sequence	ID=VSP_027047;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRR14L	Q5THK1	2036	2059	2001	2151	Alternative sequence	ID=VSP_027048;Note=In isoform 2. AEPEKRPKKVSQIRIRKTIPRPDPNLTPMGLPRPKRLKKKEFSLEEIYTNKNYKSPPANRCLETIFEEPKERNGTLISISQQKRKRVLEFQDFTVPRKRRARGKVKVAGSFTRAQKAAVQSRELDALLIQKLMELETFFAKEEEQEQSSGC->VKEEGV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF38A	Q8NAV1	166	203	1	312	Chain	ID=PRO_0000287272;Note=Pre-mRNA-splicing factor 38A
PRPF38A	Q8NAV1	166	203	1	179	Region	Note=N-terminal protein interaction domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26673105;Dbxref=PMID:26673105
PRPF38A	Q8NAV1	166	203	170	204	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRPF38A	Q8NAV1	166	203	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PRPF38A	Q8NAV1	166	203	194	194	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PRPF38A	Q8NAV1	166	203	1	187	Alternative sequence	ID=VSP_025424;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRPF38A	Q8NAV1	166	203	168	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RZ9
PRDM2	Q13029	77	128	1	1718	Chain	ID=PRO_0000041634;Note=PR domain zinc finger protein 2
PRDM2	Q13029	170	207	1	1718	Chain	ID=PRO_0000041634;Note=PR domain zinc finger protein 2
PRDM2	Q13029	77	128	28	141	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
PRDM2	Q13029	77	128	1	201	Alternative sequence	ID=VSP_018974;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PRDM2	Q13029	170	207	1	201	Alternative sequence	ID=VSP_018974;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PRDM2	Q13029	170	207	171	226	Alternative sequence	ID=VSP_046421;Note=In isoform 4. GKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSASALEQPAT->ATASAWRPDALHQRPRTSPGSIGRSKLQLQPSSRDHSSKSRHSGCSLTAPEVTWNQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRDM2	Q13029	77	128	106	106	Mutagenesis	Note=Reduced histone methyltransferase activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14633678;Dbxref=PMID:14633678
PRDM2	Q13029	170	207	188	188	Mutagenesis	Note=Loss of histone methyltransferase activity. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14633678;Dbxref=PMID:14633678
PRDM2	Q13029	170	207	196	196	Sequence conflict	Note=D->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRDM2	Q13029	170	207	200	200	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRDM2	Q13029	77	128	72	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRDM2	Q13029	77	128	81	83	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRDM2	Q13029	77	128	84	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRDM2	Q13029	77	128	93	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRDM2	Q13029	77	128	98	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRDM2	Q13029	77	128	106	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JV0
PRDM2	Q13029	77	128	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRDM2	Q13029	77	128	121	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QPW
PRG4	Q92954	25	66	25	1404	Chain	ID=PRO_0000043232;Note=Proteoglycan 4
PRG4	Q92954	106	156	25	1404	Chain	ID=PRO_0000043232;Note=Proteoglycan 4
PRG4	Q92954	156	199	25	1404	Chain	ID=PRO_0000043232;Note=Proteoglycan 4
PRG4	Q92954	25	66	26	69	Domain	Note=SMB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	66	108	Domain	Note=SMB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	106	156	66	108	Domain	Note=SMB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	156	199	159	188	Compositional bias	Note=Ser-rich
PRG4	Q92954	106	156	123	123	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25187573;Dbxref=PMID:25187573
PRG4	Q92954	106	156	136	136	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25187573;Dbxref=PMID:25187573
PRG4	Q92954	25	66	30	46	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	30	34	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	34	64	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	44	57	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	44	46	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	50	56	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	57	64	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
PRG4	Q92954	25	66	26	66	Alternative sequence	ID=VSP_016467;Note=In isoform B%2C isoform D and isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRG4	Q92954	106	156	107	199	Alternative sequence	ID=VSP_016468;Note=In isoform C and isoform D. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRG4	Q92954	156	199	107	199	Alternative sequence	ID=VSP_016468;Note=In isoform C and isoform D. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRG4	Q92954	156	199	157	199	Alternative sequence	ID=VSP_016469;Note=In isoform F. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976050;Dbxref=PMID:14976050
PRG4	Q92954	156	199	180	180	Natural variant	ID=VAR_024023;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs2273779
SCPEP1	Q9HB40	75	105	27	452	Chain	ID=PRO_0000004284;Note=Retinoid-inducible serine carboxypeptidase
SCPEP1	Q9HB40	157	182	27	452	Chain	ID=PRO_0000004284;Note=Retinoid-inducible serine carboxypeptidase
SCPEP1	Q9HB40	219	262	27	452	Chain	ID=PRO_0000004284;Note=Retinoid-inducible serine carboxypeptidase
SCPEP1	Q9HB40	293	331	27	452	Chain	ID=PRO_0000004284;Note=Retinoid-inducible serine carboxypeptidase
SCPEP1	Q9HB40	157	182	167	167	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10074
SCPEP1	Q9HB40	293	331	295	296	Alternative sequence	ID=VSP_008555;Note=In isoform 2. CL->WF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCPEP1	Q9HB40	293	331	297	452	Alternative sequence	ID=VSP_008556;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCPEP1	Q9HB40	219	262	241	241	Natural variant	ID=VAR_048685;Note=V->I;Dbxref=dbSNP:rs16957938
PRDM1	O75626	591	634	1	825	Chain	ID=PRO_0000047757;Note=PR domain zinc finger protein 1
PRDM1	O75626	591	634	575	597	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM1	O75626	591	634	603	625	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRDM1	O75626	591	634	631	653	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
PRCC	Q92733	156	172	1	491	Chain	ID=PRO_0000058568;Note=Proline-rich protein PRCC
PRCC	Q92733	172	361	1	491	Chain	ID=PRO_0000058568;Note=Proline-rich protein PRCC
PRCC	Q92733	361	393	1	491	Chain	ID=PRO_0000058568;Note=Proline-rich protein PRCC
PRCC	Q92733	172	361	235	239	Compositional bias	Note=Poly-Thr
PRCC	Q92733	156	172	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PRCC	Q92733	156	172	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PRCC	Q92733	172	361	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PRCC	Q92733	172	361	218	218	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
PRCC	Q92733	172	361	239	239	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PRCC	Q92733	172	361	241	241	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
PRCC	Q92733	172	361	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PRIMPOL	Q96LW4	185	281	1	560	Chain	ID=PRO_0000279395;Note=DNA-directed primase/polymerase protein
PRIMPOL	Q96LW4	365	395	1	560	Chain	ID=PRO_0000279395;Note=DNA-directed primase/polymerase protein
PRIMPOL	Q96LW4	185	281	1	560	Chain	ID=PRO_0000279395;Note=DNA-directed primase/polymerase protein
PRIMPOL	Q96LW4	365	395	1	560	Chain	ID=PRO_0000279395;Note=DNA-directed primase/polymerase protein
PRIMPOL	Q96LW4	185	281	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
PRIMPOL	Q96LW4	185	281	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
PRIMPOL	Q96LW4	365	395	366	366	Alternative sequence	ID=VSP_053600;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PRIMPOL	Q96LW4	365	395	366	366	Alternative sequence	ID=VSP_053600;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PRIMPOL	Q96LW4	185	281	182	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	182	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	194	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	194	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	264	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	264	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	267	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	267	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	275	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	275	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	281	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRIMPOL	Q96LW4	185	281	281	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L2X
PRELID1	Q9Y255	106	144	36	174	Domain	Note=PRELI/MSF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00158
PRELID1	Q9Y255	106	144	127	127	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRELID1	Q9Y255	106	144	142	142	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRELID2	Q8N945	69	81	1	189	Chain	ID=PRO_0000307773;Note=PRELI domain-containing protein 2
PRELID2	Q8N945	69	81	1	187	Domain	Note=PRELI/MSF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00158
PRELID2	Q8N945	69	81	69	80	Alternative sequence	ID=VSP_044841;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRELID2	Q8N945	69	81	70	81	Alternative sequence	ID=VSP_028825;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PRPF3	O43395	92	141	1	683	Chain	ID=PRO_0000097044;Note=U4/U6 small nuclear ribonucleoprotein Prp3
PRPF3	O43395	141	169	1	683	Chain	ID=PRO_0000097044;Note=U4/U6 small nuclear ribonucleoprotein Prp3
PRPF3	O43395	427	475	1	683	Chain	ID=PRO_0000097044;Note=U4/U6 small nuclear ribonucleoprotein Prp3
PRPF3	O43395	509	546	1	683	Chain	ID=PRO_0000097044;Note=U4/U6 small nuclear ribonucleoprotein Prp3
PRPF3	O43395	586	614	1	683	Chain	ID=PRO_0000097044;Note=U4/U6 small nuclear ribonucleoprotein Prp3
PRPF3	O43395	427	475	416	550	Region	Note=Mediates interaction with SART3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15314151;Dbxref=PMID:15314151
PRPF3	O43395	509	546	416	550	Region	Note=Mediates interaction with SART3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15314151;Dbxref=PMID:15314151
PRPF3	O43395	141	169	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
PRPF3	O43395	141	169	167	167	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
PRPF3	O43395	92	141	139	139	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PRPF3	O43395	92	141	1	135	Alternative sequence	ID=VSP_056265;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF3	O43395	427	475	417	683	Alternative sequence	ID=VSP_056267;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF3	O43395	509	546	417	683	Alternative sequence	ID=VSP_056267;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF3	O43395	586	614	417	683	Alternative sequence	ID=VSP_056267;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF3	O43395	141	169	142	142	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMC5	P62195	8	32	2	406	Chain	ID=PRO_0000084721;Note=26S proteasome regulatory subunit 8
PSMC5	P62195	88	107	2	406	Chain	ID=PRO_0000084721;Note=26S proteasome regulatory subunit 8
PSMC5	P62195	290	323	2	406	Chain	ID=PRO_0000084721;Note=26S proteasome regulatory subunit 8
PSMC5	P62195	360	389	2	406	Chain	ID=PRO_0000084721;Note=26S proteasome regulatory subunit 8
PSMC5	P62195	290	323	186	406	Region	Note=May mediate interaction with PRPF9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62196
PSMC5	P62195	360	389	186	406	Region	Note=May mediate interaction with PRPF9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62196
PSMC5	P62195	8	32	1	8	Alternative sequence	ID=VSP_045441;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PSMC5	P62195	290	323	300	300	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMC5	P62195	290	323	322	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KW6
PSMC5	P62195	360	389	356	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KW6
PSMC5	P62195	360	389	376	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KW6
PSMC5	P62195	360	389	380	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KW6
PSMA4	P25789	70	95	1	261	Chain	ID=PRO_0000124103;Note=Proteasome subunit alpha type-4
PSMA4	P25789	70	95	1	261	Chain	ID=PRO_0000124103;Note=Proteasome subunit alpha type-4
PSMA4	P25789	70	95	75	75	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17323924;Dbxref=PMID:17323924
PSMA4	P25789	70	95	75	75	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17323924;Dbxref=PMID:17323924
PSMA4	P25789	70	95	1	71	Alternative sequence	ID=VSP_043102;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSMA4	P25789	70	95	1	71	Alternative sequence	ID=VSP_043102;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSMA4	P25789	70	95	72	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA4	P25789	70	95	72	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA4	P25789	70	95	80	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA4	P25789	70	95	80	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA5	P28066	187	216	1	241	Chain	ID=PRO_0000124117;Note=Proteasome subunit alpha type-5
PSMA5	P28066	187	216	198	198	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
PSMA5	P28066	187	216	191	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA5	P28066	187	216	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A0Q
PSMA5	P28066	187	216	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSME3	P61289	14	25	2	254	Chain	ID=PRO_0000161789;Note=Proteasome activator complex subunit 3
PSME3	P61289	25	46	2	254	Chain	ID=PRO_0000161789;Note=Proteasome activator complex subunit 3
PSME3	P61289	46	81	2	254	Chain	ID=PRO_0000161789;Note=Proteasome activator complex subunit 3
PSME3	P61289	135	158	2	254	Chain	ID=PRO_0000161789;Note=Proteasome activator complex subunit 3
PSME3	P61289	14	25	17	17	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSME3	P61289	14	25	24	24	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PSME3	P61289	135	158	135	135	Alternative sequence	ID=VSP_004516;Note=In isoform 2. T->TPSGKGPHICFDLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7951316;Dbxref=PMID:7951316
PSME3	P61289	14	25	25	25	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSME3	P61289	25	46	25	25	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMD4	P55036	123	146	1	377	Chain	ID=PRO_0000173828;Note=26S proteasome non-ATPase regulatory subunit 4
PSMD4	P55036	146	218	1	377	Chain	ID=PRO_0000173828;Note=26S proteasome non-ATPase regulatory subunit 4
PSMD4	P55036	123	146	5	188	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
PSMD4	P55036	146	218	5	188	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
PSMD4	P55036	146	218	211	230	Domain	Note=UIM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00213
PSMD4	P55036	146	218	197	262	Region	Note=Interaction with UBQLN1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15147878;Dbxref=PMID:15147878
PSMD4	P55036	146	218	216	220	Region	Note=Essential for ubiquitin-binding
PSMD4	P55036	146	218	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YX4
PSMD4	P55036	146	218	205	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDE
PSMD4	P55036	146	218	210	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YX4
PSMD4	P55036	146	218	214	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YX4
PTCH2	Q9Y6C5	992	1038	1	1203	Chain	ID=PRO_0000205970;Note=Protein patched homolog 2
PTCH2	Q9Y6C5	405	457	1	1203	Chain	ID=PRO_0000205970;Note=Protein patched homolog 2
PTCH2	Q9Y6C5	361	405	1	1203	Chain	ID=PRO_0000205970;Note=Protein patched homolog 2
PTCH2	Q9Y6C5	361	405	79	392	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	405	457	393	413	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	361	405	393	413	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	405	457	414	428	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	405	457	429	449	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	405	457	450	457	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	992	1038	992	1012	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	992	1038	1013	1013	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	992	1038	1014	1034	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	992	1038	1035	1064	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	405	457	394	552	Domain	Note=SSD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00199
PTCH2	Q9Y6C5	361	405	394	552	Domain	Note=SSD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00199
PTCH2	Q9Y6C5	361	405	370	370	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTCH2	Q9Y6C5	992	1038	995	995	Natural variant	ID=VAR_050466;Note=V->M;Dbxref=dbSNP:rs11573591
PTCH2	Q9Y6C5	992	1038	1019	1019	Natural variant	ID=VAR_018939;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs11573591
PTGR1	Q14914	70	125	1	329	Chain	ID=PRO_0000218065;Note=Prostaglandin reductase 1
PTGR1	Q14914	51	69	1	329	Chain	ID=PRO_0000218065;Note=Prostaglandin reductase 1
PTGR1	Q14914	70	125	1	329	Chain	ID=PRO_0000218065;Note=Prostaglandin reductase 1
PTGR1	Q14914	51	69	1	329	Chain	ID=PRO_0000218065;Note=Prostaglandin reductase 1
PTGR1	Q14914	51	69	49	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	51	69	49	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	51	69	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	51	69	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	51	69	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	51	69	67	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	84	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	84	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	91	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	91	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	115	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	115	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	124	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
PTGR1	Q14914	70	125	124	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y05
CTSA	P10619	102	119	29	480	Chain	ID=PRO_0000004274;Note=Lysosomal protective protein
CTSA	P10619	388	418	29	480	Chain	ID=PRO_0000004274;Note=Lysosomal protective protein
CTSA	P10619	102	119	29	480	Chain	ID=PRO_0000004274;Note=Lysosomal protective protein
CTSA	P10619	388	418	29	480	Chain	ID=PRO_0000004274;Note=Lysosomal protective protein
CTSA	P10619	102	119	29	326	Chain	ID=PRO_0000004275;Note=Lysosomal protective protein 32 kDa chain
CTSA	P10619	102	119	29	326	Chain	ID=PRO_0000004275;Note=Lysosomal protective protein 32 kDa chain
CTSA	P10619	388	418	327	480	Chain	ID=PRO_0000004276;Note=Lysosomal protective protein 20 kDa chain
CTSA	P10619	388	418	327	480	Chain	ID=PRO_0000004276;Note=Lysosomal protective protein 20 kDa chain
CTSA	P10619	388	418	400	400	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSA	P10619	388	418	400	400	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSA	P10619	102	119	88	362	Disulfide bond	.
CTSA	P10619	102	119	88	362	Disulfide bond	.
CTSA	P10619	102	119	102	118	Alternative sequence	ID=VSP_054832;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSA	P10619	102	119	102	118	Alternative sequence	ID=VSP_054832;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSA	P10619	388	418	395	395	Natural variant	ID=VAR_001389;Note=In GSL%3B loss of activity. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8514852;Dbxref=dbSNP:rs137854543,PMID:8514852
CTSA	P10619	388	418	395	395	Natural variant	ID=VAR_001389;Note=In GSL%3B loss of activity. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8514852;Dbxref=dbSNP:rs137854543,PMID:8514852
CTSA	P10619	388	418	406	406	Natural variant	ID=VAR_063021;Note=In GSL. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8968752;Dbxref=dbSNP:rs137854548,PMID:8968752
CTSA	P10619	388	418	406	406	Natural variant	ID=VAR_063021;Note=In GSL. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8968752;Dbxref=dbSNP:rs137854548,PMID:8968752
CTSA	P10619	102	119	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	102	119	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	102	119	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	102	119	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	102	119	117	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	102	119	117	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	388	418	391	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	388	418	391	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	388	418	401	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	388	418	401	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	388	418	405	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
CTSA	P10619	388	418	405	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI9
PPID	Q08752	298	327	2	370	Chain	ID=PRO_0000064153;Note=Peptidyl-prolyl cis-trans isomerase D
PPID	Q08752	174	215	2	370	Chain	ID=PRO_0000064153;Note=Peptidyl-prolyl cis-trans isomerase D
PPID	Q08752	174	215	19	183	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPID	Q08752	298	327	273	306	Repeat	Note=TPR 2
PPID	Q08752	298	327	307	340	Repeat	Note=TPR 3
PPID	Q08752	174	215	185	215	Region	Note=Chaperone activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPID	Q08752	298	327	214	370	Region	Note=Interaction with HSP90AB1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPID	Q08752	174	215	214	370	Region	Note=Interaction with HSP90AB1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPID	Q08752	174	215	198	198	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
PPID	Q08752	174	215	196	196	Natural variant	ID=VAR_051771;Note=D->V;Dbxref=dbSNP:rs2230222
PPID	Q08752	298	327	302	302	Natural variant	ID=VAR_021022;Note=L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs9410
PPID	Q08752	298	327	308	308	Mutagenesis	Note=Abolishes interaction with HSP90AB1 and impairs interaction with HSPA8. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12145316,ECO:0000269|PubMed:15497503;Dbxref=PMID:12145316,PMID:15497503
PPID	Q08752	298	327	312	312	Mutagenesis	Note=Abolishes interaction with HSP90AB1 and impairs interaction with HSPA8. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12145316,ECO:0000269|PubMed:15497503;Dbxref=PMID:12145316,PMID:15497503
PPIH	O43447	52	66	2	177	Chain	ID=PRO_0000064162;Note=Peptidyl-prolyl cis-trans isomerase H
PPIH	O43447	81	112	2	177	Chain	ID=PRO_0000064162;Note=Peptidyl-prolyl cis-trans isomerase H
PPIH	O43447	52	66	14	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIH	O43447	81	112	14	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
PPIH	O43447	81	112	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MZW
PPIH	O43447	81	112	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MZW
PPIH	O43447	81	112	109	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MZW
PPM1D	O15297	339	420	1	605	Chain	ID=PRO_0000057752;Note=Protein phosphatase 1D
PPM1D	O15297	339	420	8	375	Domain	Note=PPM-type phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01082
PPM1D	O15297	339	420	366	366	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPM1D	O15297	339	420	404	605	Natural variant	ID=VAR_080081;Note=In IDDGIP. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28343630;Dbxref=PMID:28343630
PPM1D	O15297	339	420	407	605	Natural variant	ID=VAR_080082;Note=In IDDGIP. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28343630;Dbxref=PMID:28343630
RGL3	Q3MIN7	588	639	1	710	Chain	ID=PRO_0000306799;Note=Ral guanine nucleotide dissociation stimulator-like 3
RGL3	Q3MIN7	443	454	1	710	Chain	ID=PRO_0000306799;Note=Ral guanine nucleotide dissociation stimulator-like 3
RGL3	Q3MIN7	414	443	1	710	Chain	ID=PRO_0000306799;Note=Ral guanine nucleotide dissociation stimulator-like 3
RGL3	Q3MIN7	124	141	1	710	Chain	ID=PRO_0000306799;Note=Ral guanine nucleotide dissociation stimulator-like 3
RGL3	Q3MIN7	124	141	65	200	Domain	Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135
RGL3	Q3MIN7	443	454	247	505	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RGL3	Q3MIN7	414	443	247	505	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RGL3	Q3MIN7	588	639	613	700	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
RGL3	Q3MIN7	588	639	612	707	Region	Note=Interaction with HRAS%2C MRAS and RIT1;Ontology_term=ECO:0000250;evidence=ECO:0000250
RGL3	Q3MIN7	588	639	537	607	Compositional bias	Note=Pro-rich
RGL3	Q3MIN7	588	639	591	591	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
RGL3	Q3MIN7	588	639	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
RGL3	Q3MIN7	588	639	615	615	Natural variant	ID=VAR_035300;Note=R->C;Dbxref=dbSNP:rs2291516
PFN4	Q8NHR9	39	85	1	129	Chain	ID=PRO_0000199581;Note=Profilin-4
PSEN1	P49768	256	289	1	298	Chain	ID=PRO_0000025591;Note=Presenilin-1 NTF subunit
PSEN1	P49768	318	376	299	467	Chain	ID=PRO_0000025592;Note=Presenilin-1 CTF subunit
PSEN1	P49768	318	376	346	467	Chain	ID=PRO_0000236055;Note=Presenilin-1 CTF12
PSEN1	P49768	256	289	249	272	Transmembrane	Note=Helical;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26280335;Dbxref=PMID:26280335
PSEN1	P49768	256	289	273	380	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26280335;Dbxref=PMID:26280335
PSEN1	P49768	318	376	273	380	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26280335;Dbxref=PMID:26280335
PSEN1	P49768	318	376	322	450	Region	Note=Required for interaction with CTNNB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9738936;Dbxref=PMID:9738936
PSEN1	P49768	318	376	372	399	Region	Note=Required for interaction with CTNND2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10037471;Dbxref=PMID:10037471
PSEN1	P49768	256	289	257	257	Active site	Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10206644,ECO:0000305|PubMed:10899933,ECO:0000305|PubMed:15341515;Dbxref=PMID:10206644,PMID:10899933,PMID:15341515
PSEN1	P49768	318	376	345	346	Site	Note=Cleavage%3B by caspase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9485372;Dbxref=PMID:9485372
PSEN1	P49768	318	376	346	346	Modified residue	Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14576165;Dbxref=PMID:14576165
PSEN1	P49768	318	376	367	367	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
PSEN1	P49768	256	289	185	467	Alternative sequence	ID=VSP_007987;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PSEN1	P49768	318	376	185	467	Alternative sequence	ID=VSP_007987;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PSEN1	P49768	256	289	257	289	Alternative sequence	ID=VSP_041440;Note=In isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSEN1	P49768	318	376	319	467	Alternative sequence	ID=VSP_005192;Note=In isoform 3 and isoform 5. STERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI->RACLPPAAINLLSIAPMAPRLFMPKGACRPTAQKGSHKTLLQRMMMAGSVRNGKPRGTVI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8641442,ECO:0000303|Ref.5;Dbxref=PMID:8641442
PSEN1	P49768	318	376	319	376	Alternative sequence	ID=VSP_012288;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSEN1	P49768	256	289	260	260	Natural variant	ID=VAR_006441;Note=In AD3. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7651536,ECO:0000269|PubMed:9521423;Dbxref=dbSNP:rs63751420,PMID:7651536,PMID:9521423
PSEN1	P49768	256	289	261	261	Natural variant	ID=VAR_075270;Note=In AD3%3B unknown pathological significance%3B nearly abolishes protease activity with APP. V->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11524469,ECO:0000269|PubMed:26280335;Dbxref=dbSNP:rs63750964,PMID:11524469,PMID:26280335
PSEN1	P49768	256	289	262	262	Natural variant	ID=VAR_006442;Note=In AD3. L->F;Dbxref=dbSNP:rs63750248
PSEN1	P49768	256	289	262	262	Natural variant	ID=VAR_070025;Note=In AD3. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22503161;Dbxref=PMID:22503161
PSEN1	P49768	256	289	263	263	Natural variant	ID=VAR_006443;Note=In AD3. C->R;Dbxref=dbSNP:rs63750543
PSEN1	P49768	256	289	264	264	Natural variant	ID=VAR_006444;Note=In AD3. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10441572,ECO:0000269|PubMed:8634712,ECO:0000269|PubMed:9521423;Dbxref=dbSNP:rs63750301,PMID:10441572,PMID:8634712,PMID:9521423
PSEN1	P49768	256	289	266	266	Natural variant	ID=VAR_016219;Note=In AD3. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11920851;Dbxref=dbSNP:rs121917807,PMID:11920851
PSEN1	P49768	256	289	267	267	Natural variant	ID=VAR_006445;Note=In AD3. P->S;Dbxref=dbSNP:rs63751229
PSEN1	P49768	256	289	267	267	Natural variant	ID=VAR_006446;Note=In AD3. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7550356;Dbxref=PMID:7550356
PSEN1	P49768	256	289	269	269	Natural variant	ID=VAR_006447;Note=In AD3. R->G;Dbxref=dbSNP:rs63751019
PSEN1	P49768	256	289	269	269	Natural variant	ID=VAR_006448;Note=In AD3. R->H;Dbxref=dbSNP:rs63750900
PSEN1	P49768	256	289	271	271	Natural variant	ID=VAR_016220;Note=In AD3. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12493737;Dbxref=dbSNP:rs63750886,PMID:12493737
PSEN1	P49768	256	289	274	274	Natural variant	ID=VAR_075271;Note=In AD3%3B unknown pathological significance. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524469;Dbxref=dbSNP:rs63750284,PMID:11524469
PSEN1	P49768	256	289	278	278	Natural variant	ID=VAR_006449;Note=In AD3. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9172170;Dbxref=dbSNP:rs63749891,PMID:9172170
PSEN1	P49768	256	289	280	280	Natural variant	ID=VAR_006450;Note=In AD3. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7550356,ECO:0000269|PubMed:9298817;Dbxref=dbSNP:rs63750231,PMID:7550356,PMID:9298817
PSEN1	P49768	256	289	280	280	Natural variant	ID=VAR_006451;Note=In AD3. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7550356;Dbxref=dbSNP:rs63750231,PMID:7550356
PSEN1	P49768	256	289	282	282	Natural variant	ID=VAR_009212;Note=In AD3. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10533070;Dbxref=dbSNP:rs63750050,PMID:10533070
PSEN1	P49768	256	289	285	285	Natural variant	ID=VAR_006452;Note=In AD3. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7651536;Dbxref=dbSNP:rs63751139,PMID:7651536
PSEN1	P49768	256	289	286	286	Natural variant	ID=VAR_006453;Note=In AD3. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7596406;Dbxref=dbSNP:rs63751235,PMID:7596406
PSEN1	P49768	256	289	289	289	Natural variant	ID=VAR_010127;Note=In AD3. S->C
PSEN1	P49768	318	376	318	318	Natural variant	ID=VAR_006454;Note=Polymorphism. E->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10441572,ECO:0000269|PubMed:10533070,ECO:0000269|PubMed:10631141,ECO:0000269|PubMed:11524469,ECO:0000269|PubMed:18485326,ECO:0000269|PubMed:9384602,ECO:0000269|PubMed:9851443,ECO:0000269|PubMed:9851450,ECO:0000269|PubMed:9915968;Dbxref=dbSNP:rs17125721,PMID:10441572,PMID:10533070,PMID:10631141,PMID:11524469,PMID:18485326,PMID:9384602,PMID:9851443,PMID:9851450,PMID:9915968
PSEN1	P49768	318	376	333	333	Natural variant	ID=VAR_064902;Note=In CMD1U. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17186461;Dbxref=dbSNP:rs121917809,PMID:17186461
PSEN1	P49768	318	376	352	352	Natural variant	ID=VAR_075272;Note=In AD3%3B unknown pathological significance. R->RR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524469;Dbxref=PMID:11524469
PSEN1	P49768	318	376	354	354	Natural variant	ID=VAR_075273;Note=In AD3%3B unknown pathological significance. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524469;Dbxref=dbSNP:rs63751164,PMID:11524469
PSEN1	P49768	318	376	358	358	Natural variant	ID=VAR_075274;Note=In AD3%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524469;Dbxref=dbSNP:rs63751174,PMID:11524469
PSEN1	P49768	318	376	365	365	Natural variant	ID=VAR_075275;Note=In AD3%3B unknown pathological significance. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524469;Dbxref=dbSNP:rs63750941,PMID:11524469
PSEN1	P49768	256	289	256	256	Mutagenesis	Note=Alters gamma-secretase cleavage specificity. Increased production of amyloid-beta protein 42. No effect on enzymatic activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15341515;Dbxref=PMID:15341515
PSEN1	P49768	256	289	257	257	Mutagenesis	Note=Loss of endoproteolytic cleavage%3B reduces production of amyloid-beta in APP processing and of NICD in NOTCH1 processing. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206644,ECO:0000269|PubMed:10899933,ECO:0000269|PubMed:15341515;Dbxref=PMID:10206644,PMID:10899933,PMID:15341515
PSEN1	P49768	256	289	257	257	Mutagenesis	Note=Abolishes gamma-secretase activity. Reduces production of amyloid-beta in APP processing. Accumulation of full-length PS1. Loss of binding of transition state analog gamma-secretase inhibitor. D->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206644,ECO:0000269|PubMed:10899933,ECO:0000269|PubMed:15341515;Dbxref=PMID:10206644,PMID:10899933,PMID:15341515
PSEN1	P49768	256	289	286	286	Mutagenesis	Note=Increases production of amyloid-beta in APP processing. L->A%2CE%2CP%2CQ%2CR%2CW;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10811883;Dbxref=PMID:10811883
PSEN1	P49768	256	289	286	286	Mutagenesis	Note=Reduces production of NICD in NOTCH1 processing. L->E%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10811883;Dbxref=PMID:10811883
PSEN1	P49768	318	376	345	345	Mutagenesis	Note=Abolishes caspase cleavage. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9485372;Dbxref=PMID:9485372
PSEN1	P49768	318	376	346	346	Mutagenesis	Note=Abolishes PKC-mediated phosphorylation%3B no effect on PKA-mediated phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14576165;Dbxref=PMID:14576165
PSEN1	P49768	318	376	346	346	Mutagenesis	Note=Inhibits caspase-mediated cleavage. Modulates progression of apoptosis. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14576165;Dbxref=PMID:14576165
PSEN1	P49768	318	376	373	373	Mutagenesis	Note=No effect on caspase cleavage. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9485372;Dbxref=PMID:9485372
PSEN1	P49768	256	289	243	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
PSEN1	P49768	318	376	341	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KR6
PSEN1	P49768	318	376	356	368	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KR6
PSMF1	Q92530	43	94	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	122	183	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	184	201	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	202	254	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	43	94	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	122	183	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	184	201	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	202	254	2	271	Chain	ID=PRO_0000220920;Note=Proteasome inhibitor PI31 subunit
PSMF1	Q92530	43	94	2	150	Region	Note=Important for homodimerization and interaction with FBXO7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	122	183	2	150	Region	Note=Important for homodimerization and interaction with FBXO7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	43	94	2	150	Region	Note=Important for homodimerization and interaction with FBXO7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	122	183	2	150	Region	Note=Important for homodimerization and interaction with FBXO7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	122	183	154	271	Compositional bias	Note=Pro-rich
PSMF1	Q92530	184	201	154	271	Compositional bias	Note=Pro-rich
PSMF1	Q92530	202	254	154	271	Compositional bias	Note=Pro-rich
PSMF1	Q92530	122	183	154	271	Compositional bias	Note=Pro-rich
PSMF1	Q92530	184	201	154	271	Compositional bias	Note=Pro-rich
PSMF1	Q92530	202	254	154	271	Compositional bias	Note=Pro-rich
PSMF1	Q92530	122	183	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSMF1	Q92530	122	183	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSMF1	Q92530	202	254	205	205	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHL8
PSMF1	Q92530	202	254	205	205	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHL8
PSMF1	Q92530	202	254	219	219	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHL8
PSMF1	Q92530	202	254	219	219	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHL8
PSMF1	Q92530	202	254	231	231	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PSMF1	Q92530	202	254	231	231	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PSMF1	Q92530	202	254	252	252	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
PSMF1	Q92530	202	254	252	252	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
PSMF1	Q92530	122	183	174	174	Natural variant	ID=VAR_022153;Note=H->R;Dbxref=dbSNP:rs2235587
PSMF1	Q92530	122	183	174	174	Natural variant	ID=VAR_022153;Note=H->R;Dbxref=dbSNP:rs2235587
PSMF1	Q92530	43	94	83	83	Mutagenesis	Note=Abolishes interaction with FBXO7%2C but has no effect on homodimerization%3B when associated with E-90. I->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	43	94	83	83	Mutagenesis	Note=Abolishes interaction with FBXO7%2C but has no effect on homodimerization%3B when associated with E-90. I->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	43	94	90	90	Mutagenesis	Note=Abolishes interaction with FBXO7%2C but has no effect on homodimerization%3B when associated with E-83. I->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	43	94	90	90	Mutagenesis	Note=Abolishes interaction with FBXO7%2C but has no effect on homodimerization%3B when associated with E-83. I->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18495667;Dbxref=PMID:18495667
PSMF1	Q92530	43	94	35	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	35	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	56	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	56	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	62	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	62	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	77	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	77	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	88	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	43	94	88	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	127	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	127	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	139	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMF1	Q92530	122	183	139	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OUH
PSMG1	O95456	131	152	2	288	Chain	ID=PRO_0000080018;Note=Proteasome assembly chaperone 1
PSMG1	O95456	131	152	132	152	Alternative sequence	ID=VSP_017261;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:19054851,ECO:0000303|Ref.2;Dbxref=PMID:19054851
PSEN2	P49810	262	295	1	297	Chain	ID=PRO_0000025603;Note=Presenilin-2 NTF subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
PSEN2	P49810	262	295	250	270	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSEN2	P49810	262	295	271	361	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSEN2	P49810	262	295	263	263	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10652302;Dbxref=PMID:10652302
PSEN2	P49810	262	295	263	296	Alternative sequence	ID=VSP_005194;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSEN2	P49810	262	295	263	263	Mutagenesis	Note=Reduces production of amyloid-beta in APP processing. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10652302;Dbxref=PMID:10652302
PSEN2	P49810	262	295	295	295	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBM33	Q96EV2	579	683	2	1170	Chain	ID=PRO_0000292982;Note=RNA-binding protein 33
RBM33	Q96EV2	993	1062	2	1170	Chain	ID=PRO_0000292982;Note=RNA-binding protein 33
RBM33	Q96EV2	579	683	306	659	Compositional bias	Note=Pro-rich
RBM33	Q96EV2	579	683	605	641	Compositional bias	Note=His-rich
RBM33	Q96EV2	993	1062	1028	1028	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM33	Q96EV2	993	1062	1028	1028	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM33	Q96EV2	579	683	269	1170	Alternative sequence	ID=VSP_030144;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBM33	Q96EV2	993	1062	269	1170	Alternative sequence	ID=VSP_030144;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBM34	P42696	199	219	1	430	Chain	ID=PRO_0000081790;Note=RNA-binding protein 34
RBM34	P42696	199	219	185	280	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
LMO1	P25800	80	121	1	156	Chain	ID=PRO_0000075894;Note=Rhombotin-1
LMO1	P25800	80	121	24	83	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
LMO1	P25800	80	121	88	147	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
RNASEH2B	Q5TBB1	45	81	2	312	Chain	ID=PRO_0000248378;Note=Ribonuclease H2 subunit B
RNASEH2B	Q5TBB1	247	274	2	312	Chain	ID=PRO_0000248378;Note=Ribonuclease H2 subunit B
RNASEH2B	Q5TBB1	247	274	248	257	Alternative sequence	ID=VSP_054039;Note=In isoform 2. KIKLSDEPVE->MAAQRQKRGK;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNASEH2B	Q5TBB1	247	274	258	312	Alternative sequence	ID=VSP_054040;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNASEH2B	Q5TBB1	45	81	60	60	Natural variant	ID=VAR_027280;Note=In AGS2%3B heterozygous compound with T-177. L->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16845400,ECO:0000269|PubMed:17846997;Dbxref=dbSNP:rs75325951,PMID:16845400,PMID:17846997
RNASEH2B	Q5TBB1	45	81	73	73	Natural variant	ID=VAR_070612;Note=In AGS2%3B reduces stability of the RNase complex. W->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17846997,ECO:0000269|PubMed:21177858;Dbxref=dbSNP:rs78071087,PMID:17846997,PMID:21177858
RNASEH2B	Q5TBB1	45	81	61	61	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNASEH2B	Q5TBB1	45	81	61	61	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNASEH2B	Q5TBB1	45	81	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUF
RNASEH2B	Q5TBB1	45	81	47	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUF
RNASEH2B	Q5TBB1	45	81	55	58	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUF
RNASEH2B	Q5TBB1	45	81	59	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUF
RNASEH2B	Q5TBB1	45	81	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUF
RNASEH2B	Q5TBB1	45	81	78	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUF
REG1A	P05451	61	107	23	166	Chain	ID=PRO_0000017424;Note=Lithostathine-1-alpha
REG1A	P05451	61	107	34	164	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG1A	P05451	61	107	64	162	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00040,ECO:0000269|PubMed:2226837;Dbxref=PMID:2226837
REG1A	P05451	61	107	101	101	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
REG1A	P05451	61	107	57	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QDD
REG1A	P05451	61	107	78	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QDD
REG1A	P05451	61	107	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QDD
REG1A	P05451	61	107	107	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QDD
RNLS	Q5VYX0	175	233	18	342	Chain	ID=PRO_0000019588;Note=Renalase
RNLS	Q5VYX0	122	175	18	342	Chain	ID=PRO_0000019588;Note=Renalase
RNLS	Q5VYX0	122	175	113	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	122	175	125	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	122	175	132	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	122	175	139	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	122	175	152	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	122	175	163	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	175	233	173	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	122	175	173	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	175	233	179	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	175	233	193	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	175	233	211	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	175	233	219	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RNLS	Q5VYX0	175	233	227	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QJ4
RGS5	O15539	15	51	1	181	Chain	ID=PRO_0000204188;Note=Regulator of G-protein signaling 5
RGS5	O15539	15	51	1	108	Alternative sequence	ID=VSP_043094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15670159;Dbxref=PMID:15670159
RNPEPL1	Q9HAU8	43	81	1	725	Chain	ID=PRO_0000095094;Note=Aminopeptidase RNPEPL1
RHBDD2	Q6NTF9	59	195	1	364	Chain	ID=PRO_0000254596;Note=Rhomboid domain-containing protein 2
RHBDD2	Q6NTF9	59	195	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD2	Q6NTF9	59	195	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD2	Q6NTF9	59	195	158	178	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD2	Q6NTF9	59	195	184	204	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD2	Q6NTF9	59	195	1	141	Alternative sequence	ID=VSP_055608;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RHBDD2	Q6NTF9	59	195	85	85	Natural variant	ID=VAR_051581;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23386608;Dbxref=dbSNP:rs11547498,PMID:23386608
RHBDD2	Q6NTF9	59	195	77	77	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGAP4	P98171	641	718	1	946	Chain	ID=PRO_0000056701;Note=Rho GTPase-activating protein 4
ARHGAP4	P98171	534	560	1	946	Chain	ID=PRO_0000056701;Note=Rho GTPase-activating protein 4
ARHGAP4	P98171	344	378	1	946	Chain	ID=PRO_0000056701;Note=Rho GTPase-activating protein 4
ARHGAP4	P98171	145	166	1	946	Chain	ID=PRO_0000056701;Note=Rho GTPase-activating protein 4
ARHGAP4	P98171	145	166	19	317	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
ARHGAP4	P98171	641	718	507	695	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP4	P98171	534	560	507	695	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP4	P98171	145	166	128	195	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARHGAP28	Q9P2N2	212	242	1	729	Chain	ID=PRO_0000280476;Note=Rho GTPase-activating protein 28
ARHGAP28	Q9P2N2	404	430	1	729	Chain	ID=PRO_0000280476;Note=Rho GTPase-activating protein 28
ARHGAP28	Q9P2N2	404	430	380	577	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP32	A7KAX9	281	307	1	2087	Chain	ID=PRO_0000345203;Note=Rho GTPase-activating protein 32
ARHGAP32	A7KAX9	134	163	1	2087	Chain	ID=PRO_0000345203;Note=Rho GTPase-activating protein 32
ARHGAP32	A7KAX9	134	163	131	245	Domain	Note=PX%3B atypical
ARHGAP32	A7KAX9	281	307	259	321	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ARHGAP32	A7KAX9	281	307	1	349	Alternative sequence	ID=VSP_034933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12446789,ECO:0000303|PubMed:12531901,ECO:0000303|PubMed:12819203,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9872452;Dbxref=PMID:12446789,PMID:12531901,PMID:12819203,PMID:15489334,PMID:9872452
ARHGAP32	A7KAX9	134	163	1	349	Alternative sequence	ID=VSP_034933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12446789,ECO:0000303|PubMed:12531901,ECO:0000303|PubMed:12819203,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9872452;Dbxref=PMID:12446789,PMID:12531901,PMID:12819203,PMID:15489334,PMID:9872452
ARHGAP32	A7KAX9	281	307	1	290	Alternative sequence	ID=VSP_034934;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGAP32	A7KAX9	134	163	1	290	Alternative sequence	ID=VSP_034934;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RHOBTB1	O94844	99	160	1	696	Chain	ID=PRO_0000198960;Note=Rho-related BTB domain-containing protein 1
RHOBTB1	O94844	99	160	1	696	Chain	ID=PRO_0000198960;Note=Rho-related BTB domain-containing protein 1
RHOBTB1	O94844	99	160	140	143	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOBTB1	O94844	99	160	140	143	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOBTB1	O94844	99	160	1	210	Region	Note=Rho-like
RHOBTB1	O94844	99	160	1	210	Region	Note=Rho-like
RHBDF2	Q6PJF5	438	463	1	856	Chain	ID=PRO_0000341938;Note=Inactive rhomboid protein 2
RHBDF2	Q6PJF5	253	296	1	856	Chain	ID=PRO_0000341938;Note=Inactive rhomboid protein 2
RHBDF2	Q6PJF5	253	296	1	409	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDF2	Q6PJF5	438	463	431	660	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ARHGAP27	Q6ZUM4	750	795	1	889	Chain	ID=PRO_0000317578;Note=Rho GTPase-activating protein 27
ARHGAP27	Q6ZUM4	724	750	1	889	Chain	ID=PRO_0000317578;Note=Rho GTPase-activating protein 27
ARHGAP27	Q6ZUM4	691	724	1	889	Chain	ID=PRO_0000317578;Note=Rho GTPase-activating protein 27
ARHGAP27	Q6ZUM4	471	493	1	889	Chain	ID=PRO_0000317578;Note=Rho GTPase-activating protein 27
ARHGAP27	Q6ZUM4	416	443	1	889	Chain	ID=PRO_0000317578;Note=Rho GTPase-activating protein 27
ARHGAP27	Q6ZUM4	416	443	411	444	Domain	Note=WW 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
ARHGAP27	Q6ZUM4	750	795	697	886	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP27	Q6ZUM4	724	750	697	886	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP27	Q6ZUM4	691	724	697	886	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP27	Q6ZUM4	750	795	264	889	Alternative sequence	ID=VSP_031055;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15498874;Dbxref=PMID:15489334,PMID:15498874
ARHGAP27	Q6ZUM4	724	750	264	889	Alternative sequence	ID=VSP_031055;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15498874;Dbxref=PMID:15489334,PMID:15498874
ARHGAP27	Q6ZUM4	691	724	264	889	Alternative sequence	ID=VSP_031055;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15498874;Dbxref=PMID:15489334,PMID:15498874
ARHGAP27	Q6ZUM4	471	493	264	889	Alternative sequence	ID=VSP_031055;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15498874;Dbxref=PMID:15489334,PMID:15498874
ARHGAP27	Q6ZUM4	416	443	264	889	Alternative sequence	ID=VSP_031055;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15498874;Dbxref=PMID:15489334,PMID:15498874
ARHGAP27	Q6ZUM4	416	443	416	442	Alternative sequence	ID=VSP_031056;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RAD54L	Q92698	458	495	1	747	Chain	ID=PRO_0000074337;Note=DNA repair and recombination protein RAD54-like
RAD54L	Q92698	563	623	1	747	Chain	ID=PRO_0000074337;Note=DNA repair and recombination protein RAD54-like
RAD54L	Q92698	458	495	1	747	Chain	ID=PRO_0000074337;Note=DNA repair and recombination protein RAD54-like
RAD54L	Q92698	563	623	1	747	Chain	ID=PRO_0000074337;Note=DNA repair and recombination protein RAD54-like
RAD54L	Q92698	563	623	500	653	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
RAD54L	Q92698	563	623	500	653	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
RAD54L	Q92698	563	623	583	583	Natural variant	ID=VAR_055368;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs28363243
RAD54L	Q92698	563	623	583	583	Natural variant	ID=VAR_055368;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs28363243
RASEF	Q8IZ41	320	342	1	740	Chain	ID=PRO_0000299577;Note=Ras and EF-hand domain-containing protein
RASEF	Q8IZ41	255	281	1	740	Chain	ID=PRO_0000299577;Note=Ras and EF-hand domain-containing protein
RASEF	Q8IZ41	320	342	175	356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RASEF	Q8IZ41	255	281	175	356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RASEF	Q8IZ41	320	342	190	740	Alternative sequence	ID=VSP_027767;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RASEF	Q8IZ41	255	281	190	740	Alternative sequence	ID=VSP_027767;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RASEF	Q8IZ41	255	281	262	262	Natural variant	ID=VAR_034858;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16015647;Dbxref=dbSNP:rs4146960,PMID:16015647
RBPMS2	Q6ZRY4	55	68	2	209	Chain	ID=PRO_0000274909;Note=RNA-binding protein with multiple splicing 2
RBPMS2	Q6ZRY4	29	55	2	209	Chain	ID=PRO_0000274909;Note=RNA-binding protein with multiple splicing 2
RBPMS2	Q6ZRY4	55	68	31	108	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBPMS2	Q6ZRY4	29	55	31	108	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBPMS2	Q6ZRY4	29	55	41	51	Region	Note=Important for homodimerization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25064856;Dbxref=PMID:25064856
RBPMS2	Q6ZRY4	55	68	1	111	Alternative sequence	ID=VSP_056896;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBPMS2	Q6ZRY4	29	55	1	111	Alternative sequence	ID=VSP_056896;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBPMS2	Q6ZRY4	29	55	49	49	Mutagenesis	Note=Strongly reduces homodimerization and interaction with EEF2. Strongly reduces NOG mRNA binding. Loss of function in gastrointestinal smooth muscle cell differentiation. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25064856;Dbxref=PMID:25064856
RBPMS2	Q6ZRY4	29	55	49	49	Mutagenesis	Note=No effect on homodimerization. No effect on function in gastrointestinal smooth muscle cell differentiation. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25064856;Dbxref=PMID:25064856
RBPMS2	Q6ZRY4	29	55	32	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M9K
RBPMS2	Q6ZRY4	29	55	44	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M9K
RBPMS2	Q6ZRY4	29	55	52	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M9K
RBPMS2	Q6ZRY4	55	68	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M9K
RBM28	Q9NW13	571	596	2	759	Chain	ID=PRO_0000081785;Note=RNA-binding protein 28
RBM28	Q9NW13	149	180	2	759	Chain	ID=PRO_0000081785;Note=RNA-binding protein 28
RBM28	Q9NW13	149	180	114	191	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM28	Q9NW13	571	596	487	597	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM28	Q9NW13	149	180	39	179	Alternative sequence	ID=VSP_046111;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SDR16C5	Q8N3Y7	237	278	1	309	Chain	ID=PRO_0000305973;Note=Epidermal retinol dehydrogenase 2
SDR16C5	Q8N3Y7	111	155	1	309	Chain	ID=PRO_0000305973;Note=Epidermal retinol dehydrogenase 2
SDR16C5	Q8N3Y7	237	278	270	290	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDR16C5	Q8N3Y7	111	155	112	155	Alternative sequence	ID=VSP_028389;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SDR16C5	Q8N3Y7	111	155	116	116	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
RASA4B	C9J798	610	656	1	803	Chain	ID=PRO_0000395324;Note=Ras GTPase-activating protein 4B
RASA4B	C9J798	610	656	566	673	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
RBBP4	Q09028	103	161	2	425	Chain	ID=PRO_0000051186;Note=Histone-binding protein RBBP4
RBBP4	Q09028	103	161	122	155	Repeat	Note=WD 1
RBBP4	Q09028	103	161	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
RBBP4	Q09028	103	161	160	160	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60972
RBBP4	Q09028	103	161	160	160	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
RBBP4	Q09028	103	161	100	103	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PC0
RBBP4	Q09028	103	161	115	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7A
RBBP4	Q09028	103	161	128	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7A
RBBP4	Q09028	103	161	136	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7A
RBBP4	Q09028	103	161	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7A
RBBP4	Q09028	103	161	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7A
RBBP4	Q09028	103	161	154	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7A
RBBP5	Q15291	465	529	1	538	Chain	ID=PRO_0000051194;Note=Retinoblastoma-binding protein 5
RBBP5	Q15291	73	119	1	538	Chain	ID=PRO_0000051194;Note=Retinoblastoma-binding protein 5
RBBP5	Q15291	73	119	64	103	Repeat	Note=WD 2
RBBP5	Q15291	465	529	497	497	Modified residue	Note=Phosphoserine%3B by CDK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7558034;Dbxref=PMID:7558034
RBBP5	Q15291	465	529	525	525	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
RBBP5	Q15291	465	529	492	529	Alternative sequence	ID=VSP_035583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RNF19A	Q9NV58	561	608	1	838	Chain	ID=PRO_0000056061;Note=E3 ubiquitin-protein ligase RNF19A
RNF19A	Q9NV58	435	489	1	838	Chain	ID=PRO_0000056061;Note=E3 ubiquitin-protein ligase RNF19A
RNF19A	Q9NV58	561	608	1	838	Chain	ID=PRO_0000056061;Note=E3 ubiquitin-protein ligase RNF19A
RNF19A	Q9NV58	435	489	1	838	Chain	ID=PRO_0000056061;Note=E3 ubiquitin-protein ligase RNF19A
RNF19A	Q9NV58	435	489	424	444	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF19A	Q9NV58	435	489	424	444	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF19A	Q9NV58	561	608	572	604	Alternative sequence	ID=VSP_021010;Note=In isoform 2. RYSLSGESGTVSLGTVSDNASTKAMAGSILNSY->AAVAAAGRWAYSPATLRCRRSEELKNIHDSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF19A	Q9NV58	561	608	572	604	Alternative sequence	ID=VSP_021010;Note=In isoform 2. RYSLSGESGTVSLGTVSDNASTKAMAGSILNSY->AAVAAAGRWAYSPATLRCRRSEELKNIHDSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF19A	Q9NV58	561	608	605	838	Alternative sequence	ID=VSP_021011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF19A	Q9NV58	561	608	605	838	Alternative sequence	ID=VSP_021011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF220	Q5VTB9	518	543	1	566	Chain	ID=PRO_0000277657;Note=E3 ubiquitin-protein ligase RNF220
RNF220	Q5VTB9	518	543	1	566	Chain	ID=PRO_0000277657;Note=E3 ubiquitin-protein ligase RNF220
RNF220	Q5VTB9	518	543	1	566	Chain	ID=PRO_0000277657;Note=E3 ubiquitin-protein ligase RNF220
RNF220	Q5VTB9	518	543	514	553	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF220	Q5VTB9	518	543	514	553	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF220	Q5VTB9	518	543	514	553	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF220	Q5VTB9	518	543	514	522	Region	Note=Required for targeting to the cytoplasm;Ontology_term=ECO:0000250;evidence=ECO:0000250
RNF220	Q5VTB9	518	543	514	522	Region	Note=Required for targeting to the cytoplasm;Ontology_term=ECO:0000250;evidence=ECO:0000250
RNF220	Q5VTB9	518	543	514	522	Region	Note=Required for targeting to the cytoplasm;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAD23B	P54727	315	372	1	409	Chain	ID=PRO_0000114906;Note=UV excision repair protein RAD23 homolog B
RAD23B	P54727	315	372	274	317	Domain	Note=STI1
RAD23B	P54727	315	372	364	404	Domain	Note=UBA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
RAD23B	P54727	315	372	336	348	Compositional bias	Note=Poly-Gly
RAD23B	P54727	315	372	311	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PVE
RAD23B	P54727	315	372	321	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PVE
RAD23B	P54727	315	372	335	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PVE
RECK	O95980	362	432	23	942	Chain	ID=PRO_0000016583;Note=Reversion-inducing cysteine-rich protein with Kazal motifs
RECK	O95980	525	588	23	942	Chain	ID=PRO_0000016583;Note=Reversion-inducing cysteine-rich protein with Kazal motifs
RECQL5	O94762	604	649	1	991	Chain	ID=PRO_0000205055;Note=ATP-dependent DNA helicase Q5
RECQL5	O94762	604	649	490	620	Region	Note=Interaction with POLR2A
RECQL5	O94762	604	649	411	991	Alternative sequence	ID=VSP_005568;Note=In isoform Alpha. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10471747,ECO:0000303|PubMed:10710432,ECO:0000303|PubMed:9878247;Dbxref=PMID:10471747,PMID:10710432,PMID:9878247
RECQL5	O94762	604	649	436	991	Alternative sequence	ID=VSP_005570;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10471747,ECO:0000303|PubMed:10710432,ECO:0000303|PubMed:15489334;Dbxref=PMID:10471747,PMID:10710432,PMID:15489334
RECQL5	O94762	604	649	628	628	Natural variant	ID=VAR_051733;Note=S->N;Dbxref=dbSNP:rs35566780
RECQL5	O94762	604	649	594	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BK0
REV1	Q9UBZ9	610	650	1	1251	Chain	ID=PRO_0000173992;Note=DNA repair protein REV1
REV1	Q9UBZ9	404	440	1	1251	Chain	ID=PRO_0000173992;Note=DNA repair protein REV1
REV1	Q9UBZ9	117	167	1	1251	Chain	ID=PRO_0000173992;Note=DNA repair protein REV1
REV1	Q9UBZ9	117	167	44	131	Domain	Note=BRCT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033
REV1	Q9UBZ9	610	650	419	653	Domain	Note=UmuC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
REV1	Q9UBZ9	404	440	419	653	Domain	Note=UmuC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
REV1	Q9UBZ9	404	440	423	427	Nucleotide binding	Note=dCTP binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
REV1	Q9UBZ9	404	440	423	423	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
REV1	Q9UBZ9	404	440	423	423	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
REV1	Q9UBZ9	404	440	406	413	Alternative sequence	ID=VSP_012810;Note=In isoform 3. DMSVLNSP->RYLLKLSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
REV1	Q9UBZ9	610	650	414	1251	Alternative sequence	ID=VSP_012811;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
REV1	Q9UBZ9	404	440	414	1251	Alternative sequence	ID=VSP_012811;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
REV1	Q9UBZ9	117	167	138	138	Natural variant	ID=VAR_021249;Note=V->M;Dbxref=dbSNP:rs3087403
REV1	Q9UBZ9	117	167	112	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBW
REV1	Q9UBZ9	117	167	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBW
REV1	Q9UBZ9	404	440	419	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	404	440	427	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	404	440	433	435	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	404	440	437	441	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	610	650	606	613	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	610	650	614	624	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	610	650	629	631	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	610	650	634	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	610	650	637	643	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REV1	Q9UBZ9	610	650	646	648	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GQC
REG3A	Q06141	65	111	27	175	Chain	ID=PRO_0000017429;Note=Regenerating islet-derived protein 3-alpha 16.5 kDa form
REG3A	Q06141	65	111	27	175	Chain	ID=PRO_0000017429;Note=Regenerating islet-derived protein 3-alpha 16.5 kDa form
REG3A	Q06141	65	111	27	175	Chain	ID=PRO_0000017429;Note=Regenerating islet-derived protein 3-alpha 16.5 kDa form
REG3A	Q06141	65	111	38	175	Chain	ID=PRO_0000422742;Note=Regenerating islet-derived protein 3-alpha 15 kDa form
REG3A	Q06141	65	111	38	175	Chain	ID=PRO_0000422742;Note=Regenerating islet-derived protein 3-alpha 15 kDa form
REG3A	Q06141	65	111	38	175	Chain	ID=PRO_0000422742;Note=Regenerating islet-derived protein 3-alpha 15 kDa form
REG3A	Q06141	65	111	47	172	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3A	Q06141	65	111	47	172	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3A	Q06141	65	111	47	172	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3A	Q06141	65	111	68	171	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3A	Q06141	65	111	68	171	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3A	Q06141	65	111	68	171	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
REG3A	Q06141	65	111	61	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	61	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	61	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	82	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	82	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	82	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	100	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	100	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	100	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	109	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	109	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
REG3A	Q06141	65	111	109	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MTH
PNKP	Q96T60	312	343	1	521	Chain	ID=PRO_0000058478;Note=Bifunctional polynucleotide phosphatase/kinase
PNKP	Q96T60	66	166	1	521	Chain	ID=PRO_0000058478;Note=Bifunctional polynucleotide phosphatase/kinase
PNKP	Q96T60	312	343	1	521	Chain	ID=PRO_0000058478;Note=Bifunctional polynucleotide phosphatase/kinase
PNKP	Q96T60	66	166	1	521	Chain	ID=PRO_0000058478;Note=Bifunctional polynucleotide phosphatase/kinase
PNKP	Q96T60	66	166	6	110	Domain	Note=FHA
PNKP	Q96T60	66	166	6	110	Domain	Note=FHA
PNKP	Q96T60	312	343	146	337	Region	Note=Phosphatase;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKP	Q96T60	66	166	146	337	Region	Note=Phosphatase;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKP	Q96T60	312	343	146	337	Region	Note=Phosphatase;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKP	Q96T60	66	166	146	337	Region	Note=Phosphatase;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKP	Q96T60	312	343	341	516	Region	Note=Kinase;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKP	Q96T60	312	343	341	516	Region	Note=Kinase;Ontology_term=ECO:0000250;evidence=ECO:0000250
PNKP	Q96T60	66	166	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
PNKP	Q96T60	66	166	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
PNKP	Q96T60	66	166	118	118	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PNKP	Q96T60	66	166	118	118	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PNKP	Q96T60	66	166	122	122	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:23186163
PNKP	Q96T60	66	166	122	122	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:23186163
PNKP	Q96T60	312	343	326	326	Natural variant	ID=VAR_063836;Note=In MCSZ. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20118933;Dbxref=dbSNP:rs267606956,PMID:20118933
PNKP	Q96T60	312	343	326	326	Natural variant	ID=VAR_063836;Note=In MCSZ. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20118933;Dbxref=dbSNP:rs267606956,PMID:20118933
PNKP	Q96T60	66	166	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	84	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	84	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	92	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	92	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	99	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
PNKP	Q96T60	66	166	99	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BRF
POC1B	Q8TC44	371	444	1	478	Chain	ID=PRO_0000051410;Note=POC1 centriolar protein homolog B
POC1B	Q8TC44	344	371	1	478	Chain	ID=PRO_0000051410;Note=POC1 centriolar protein homolog B
POC1B	Q8TC44	270	293	1	478	Chain	ID=PRO_0000051410;Note=POC1 centriolar protein homolog B
POC1B	Q8TC44	151	186	1	478	Chain	ID=PRO_0000051410;Note=POC1 centriolar protein homolog B
POC1B	Q8TC44	91	150	1	478	Chain	ID=PRO_0000051410;Note=POC1 centriolar protein homolog B
POC1B	Q8TC44	91	150	58	99	Repeat	Note=WD 2
POC1B	Q8TC44	91	150	101	139	Repeat	Note=WD 3
POC1B	Q8TC44	151	186	142	181	Repeat	Note=WD 4
POC1B	Q8TC44	91	150	142	181	Repeat	Note=WD 4
POC1B	Q8TC44	151	186	183	223	Repeat	Note=WD 5
POC1B	Q8TC44	270	293	268	307	Repeat	Note=WD 7
POC1B	Q8TC44	371	444	431	470	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
POC1B	Q8TC44	371	444	370	375	Compositional bias	Note=Poly-Thr
POC1B	Q8TC44	344	371	370	375	Compositional bias	Note=Poly-Thr
POC1B	Q8TC44	91	150	106	106	Natural variant	ID=VAR_071917;Note=In CORD20%3B disrupts interaction with FAM161A%3B localization of the mutant is cytosolic without enrichment at specific subcellular sites. R->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24945461,ECO:0000269|PubMed:25018096,ECO:0000269|PubMed:25044745;Dbxref=dbSNP:rs76216585,PMID:24945461,PMID:25018096,PMID:25044745
POMP	Q9Y244	54	88	1	141	Chain	ID=PRO_0000247184;Note=Proteasome maturation protein
POMP	Q9Y244	54	88	68	72	Motif	Note=High-affinity association with the preproteasome
DPF2	Q92785	258	301	2	391	Chain	ID=PRO_0000168149;Note=Zinc finger protein ubi-d4
DPF2	Q92785	258	301	270	330	Zinc finger	Note=PHD-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
DPF2	Q92785	258	301	280	280	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DPF2	Q92785	258	301	281	281	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DPF2	Q92785	258	301	156	339	Alternative sequence	ID=VSP_055860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPF2	Q92785	258	301	274	276	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC
DPF2	Q92785	258	301	284	286	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC
DPF2	Q92785	258	301	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VDC
PPP1R16A	Q96I34	235	277	1	525	Chain	ID=PRO_0000067040;Note=Protein phosphatase 1 regulatory subunit 16A
PPP1R16A	Q96I34	235	277	1	525	Chain	ID=PRO_0000067040;Note=Protein phosphatase 1 regulatory subunit 16A
PPP1R16A	Q96I34	235	277	231	260	Repeat	Note=ANK 4
PPP1R16A	Q96I34	235	277	231	260	Repeat	Note=ANK 4
PPP1R16A	Q96I34	235	277	264	293	Repeat	Note=ANK 5
PPP1R16A	Q96I34	235	277	264	293	Repeat	Note=ANK 5
PPP1R16A	Q96I34	235	277	249	249	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R16A	Q96I34	235	277	249	249	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R16A	Q96I34	235	277	272	272	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R16A	Q96I34	235	277	272	272	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R16B	Q96T49	232	274	1	564	Chain	ID=PRO_0000067043;Note=Protein phosphatase 1 regulatory inhibitor subunit 16B
PPP1R16B	Q96T49	232	274	228	257	Repeat	Note=ANK 3
PPP1R16B	Q96T49	232	274	261	290	Repeat	Note=ANK 4
PPP1R16B	Q96T49	232	274	233	274	Alternative sequence	ID=VSP_047508;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15491607;Dbxref=PMID:15491607
PPP1R16B	Q96T49	232	274	252	252	Mutagenesis	Note=Strongly decreased interaction with EEF1A1. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26497934;Dbxref=PMID:26497934
PPP1CC	P36873	249	294	2	323	Chain	ID=PRO_0000058787;Note=Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
PPP1CC	P36873	139	174	2	323	Chain	ID=PRO_0000058787;Note=Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
PPP1CC	P36873	139	174	173	173	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11535607,ECO:0000269|PubMed:15280359;Dbxref=PMID:11535607,PMID:15280359
PPP1CC	P36873	249	294	273	273	Site	Note=Inhibition by microcystin toxin binding
PPP1CC	P36873	139	174	152	152	Natural variant	ID=VAR_051734;Note=F->S;Dbxref=dbSNP:rs11558237
PPP1CC	P36873	249	294	273	273	Mutagenesis	Note=Abolishes interaction with microcystin toxin. C->A%2CS%2CL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7556599;Dbxref=PMID:7556599
PPP1CC	P36873	139	174	136	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	139	174	146	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	139	174	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	139	174	166	168	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	139	174	169	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	249	294	254	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	249	294	259	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	249	294	263	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	249	294	272	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	249	294	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1CC	P36873	249	294	290	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INB
PPP1R7	Q15435	17	60	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	79	101	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	199	238	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	273	302	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	17	60	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	79	101	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	199	238	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	273	302	2	360	Chain	ID=PRO_0000239613;Note=Protein phosphatase 1 regulatory subunit 7
PPP1R7	Q15435	79	101	77	98	Repeat	Note=LRR 1
PPP1R7	Q15435	79	101	77	98	Repeat	Note=LRR 1
PPP1R7	Q15435	79	101	99	120	Repeat	Note=LRR 2
PPP1R7	Q15435	79	101	99	120	Repeat	Note=LRR 2
PPP1R7	Q15435	199	238	187	208	Repeat	Note=LRR 6
PPP1R7	Q15435	199	238	187	208	Repeat	Note=LRR 6
PPP1R7	Q15435	199	238	209	230	Repeat	Note=LRR 7
PPP1R7	Q15435	199	238	209	230	Repeat	Note=LRR 7
PPP1R7	Q15435	199	238	231	252	Repeat	Note=LRR 8
PPP1R7	Q15435	199	238	231	252	Repeat	Note=LRR 8
PPP1R7	Q15435	273	302	253	274	Repeat	Note=LRR 9
PPP1R7	Q15435	273	302	253	274	Repeat	Note=LRR 9
PPP1R7	Q15435	273	302	275	296	Repeat	Note=LRR 10
PPP1R7	Q15435	273	302	275	296	Repeat	Note=LRR 10
PPP1R7	Q15435	273	302	297	318	Repeat	Note=LRR 11
PPP1R7	Q15435	273	302	297	318	Repeat	Note=LRR 11
PPP1R7	Q15435	17	60	24	24	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:18318008,PMID:20068231,PMID:21406692
PPP1R7	Q15435	17	60	24	24	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:18318008,PMID:20068231,PMID:21406692
PPP1R7	Q15435	17	60	27	27	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18318008,PMID:20068231,PMID:21406692,PMID:24275569
PPP1R7	Q15435	17	60	27	27	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18318008,PMID:20068231,PMID:21406692,PMID:24275569
PPP1R7	Q15435	17	60	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:24275569
PPP1R7	Q15435	17	60	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:24275569
PPP1R7	Q15435	17	60	47	47	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:24275569
PPP1R7	Q15435	17	60	47	47	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:24275569
PPP1R7	Q15435	17	60	1	60	Alternative sequence	ID=VSP_055672;Note=In isoform 5. MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R7	Q15435	17	60	1	60	Alternative sequence	ID=VSP_055672;Note=In isoform 5. MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1R7	Q15435	17	60	18	60	Alternative sequence	ID=VSP_019244;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP1R7	Q15435	17	60	18	60	Alternative sequence	ID=VSP_019244;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP1R7	Q15435	273	302	274	280	Alternative sequence	ID=VSP_019245;Note=In isoform 3%2C isoform 4 and isoform 5. NKLTMLD->VQDSLTY;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PPP1R7	Q15435	273	302	274	280	Alternative sequence	ID=VSP_019245;Note=In isoform 3%2C isoform 4 and isoform 5. NKLTMLD->VQDSLTY;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PPP1R7	Q15435	273	302	281	360	Alternative sequence	ID=VSP_019246;Note=In isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PPP1R7	Q15435	273	302	281	360	Alternative sequence	ID=VSP_019246;Note=In isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PPP1R7	Q15435	199	238	214	214	Mutagenesis	Note=Completely abolishes the interaction with protein phosphatase 1. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	199	238	214	214	Mutagenesis	Note=Completely abolishes the interaction with protein phosphatase 1. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	273	302	280	280	Mutagenesis	Note=Severely impairs the binding of protein phosphatase 1. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	273	302	280	280	Mutagenesis	Note=Severely impairs the binding of protein phosphatase 1. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	273	302	300	300	Mutagenesis	Note=Completely abolishes the interaction with protein phosphatase 1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	273	302	300	300	Mutagenesis	Note=Completely abolishes the interaction with protein phosphatase 1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	273	302	302	302	Mutagenesis	Note=Completely abolishes the interaction with protein phosphatase 1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
PPP1R7	Q15435	273	302	302	302	Mutagenesis	Note=Completely abolishes the interaction with protein phosphatase 1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12226088;Dbxref=PMID:12226088
RETSAT	Q6NUM9	266	332	19	610	Chain	ID=PRO_0000225665;Note=All-trans-retinol 13%2C14-reductase
RETSAT	Q6NUM9	57	118	19	610	Chain	ID=PRO_0000225665;Note=All-trans-retinol 13%2C14-reductase
RETSAT	Q6NUM9	57	118	70	98	Nucleotide binding	Note=FAD or NAD or NADP;Ontology_term=ECO:0000255;evidence=ECO:0000255
RETSAT	Q6NUM9	266	332	298	298	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
REXO4	Q9GZR2	333	358	1	422	Chain	ID=PRO_0000131703;Note=RNA exonuclease 4
REXO4	Q9GZR2	333	358	243	394	Domain	Note=Exonuclease
PPP2CB	P62714	162	192	1	309	Chain	ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
PPP2CB	P62714	104	162	1	309	Chain	ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
PPP2CB	P62714	34	104	1	309	Chain	ID=PRO_0000058845;Note=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
PPP2CB	P62714	104	162	118	118	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP2CB	P62714	34	104	57	57	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP2CB	P62714	34	104	59	59	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP2CB	P62714	34	104	85	85	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP2CB	P62714	34	104	85	85	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP2CB	P62714	104	162	117	117	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP2CB	P62714	162	192	167	167	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP3CB	P16298	455	465	2	524	Chain	ID=PRO_0000058825;Note=Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
PPP3CB	P16298	369	395	2	524	Chain	ID=PRO_0000058825;Note=Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
PPP3CB	P16298	369	395	357	379	Region	Note=Calcineurin B binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871
PPP3CB	P16298	369	395	395	395	Alternative sequence	ID=VSP_043803;Note=In isoform 3 and isoform 4. D->DV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1848109;Dbxref=PMID:15489334,PMID:1848109
PPP3CB	P16298	455	465	456	524	Alternative sequence	ID=VSP_005097;Note=In isoform 2. ATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ->GNDVMQLAVPQMDWGTPHSFANNSHNACREFLLFFSSCLSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2556704;Dbxref=PMID:2556704
PPP3CB	P16298	455	465	456	465	Alternative sequence	ID=VSP_012617;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1848109;Dbxref=PMID:1848109
PPP3CB	P16298	455	465	357	524	Mutagenesis	Note=Loss of catalytic activity. Loss of interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871
PPP3CB	P16298	369	395	357	524	Mutagenesis	Note=Loss of catalytic activity. Loss of interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871
PPP3CB	P16298	455	465	398	524	Mutagenesis	Note=Increases catalytic activity independently of calmodulin. Loss of interaction with calmodulin. Does not affect interaction with PPP3R1/calreticulin B. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871
PPP3CB	P16298	455	465	415	524	Mutagenesis	Note=Increases catalytic activity independently of calmodulin. Does not affect interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871
PPP3CB	P16298	455	465	451	524	Mutagenesis	Note=Increases basal catalytic activity. Does not affect interaction with PPP3R1/calreticulin B and calmodulin. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26794871;Dbxref=PMID:26794871
PPP3CB	P16298	369	395	358	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OR9
PPP3CB	P16298	369	395	381	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ORA
PPP3CB	P16298	369	395	384	386	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OR9
CHM	P24386	503	536	1	653	Chain	ID=PRO_0000056686;Note=Rab proteins geranylgeranyltransferase component A 1
CHM	P24386	389	414	1	653	Chain	ID=PRO_0000056686;Note=Rab proteins geranylgeranyltransferase component A 1
CHM	P24386	503	536	111	653	Alternative sequence	ID=VSP_042818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHM	P24386	389	414	111	653	Alternative sequence	ID=VSP_042818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHM	P24386	503	536	507	507	Natural variant	ID=VAR_066847;Note=In CHM%3B impairs the interaction with RABGGTA. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21905166;Dbxref=dbSNP:rs397514603,PMID:21905166
RANGAP1	P46060	420	460	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	258	296	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	205	258	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	160	205	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	100	160	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	80	100	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	420	460	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	258	296	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	205	258	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	160	205	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	100	160	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	80	100	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	420	460	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	258	296	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	205	258	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	160	205	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	100	160	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	80	100	2	587	Chain	ID=PRO_0000056737;Note=Ran GTPase-activating protein 1
RANGAP1	P46060	100	160	111	134	Repeat	Note=LRR 2
RANGAP1	P46060	100	160	111	134	Repeat	Note=LRR 2
RANGAP1	P46060	100	160	111	134	Repeat	Note=LRR 2
RANGAP1	P46060	205	258	207	230	Repeat	Note=LRR 3
RANGAP1	P46060	205	258	207	230	Repeat	Note=LRR 3
RANGAP1	P46060	205	258	207	230	Repeat	Note=LRR 3
RANGAP1	P46060	258	296	235	258	Repeat	Note=LRR 4
RANGAP1	P46060	205	258	235	258	Repeat	Note=LRR 4
RANGAP1	P46060	258	296	235	258	Repeat	Note=LRR 4
RANGAP1	P46060	205	258	235	258	Repeat	Note=LRR 4
RANGAP1	P46060	258	296	235	258	Repeat	Note=LRR 4
RANGAP1	P46060	205	258	235	258	Repeat	Note=LRR 4
RANGAP1	P46060	258	296	292	319	Repeat	Note=LRR 5
RANGAP1	P46060	258	296	292	319	Repeat	Note=LRR 5
RANGAP1	P46060	258	296	292	319	Repeat	Note=LRR 5
RANGAP1	P46060	420	460	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000269|PubMed:15037602;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:15037602
RANGAP1	P46060	420	460	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000269|PubMed:15037602;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:15037602
RANGAP1	P46060	420	460	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000269|PubMed:15037602;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:15037602
RANGAP1	P46060	420	460	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RANGAP1	P46060	420	460	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RANGAP1	P46060	420	460	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RANGAP1	P46060	420	460	436	436	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RANGAP1	P46060	420	460	436	436	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RANGAP1	P46060	420	460	436	436	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RANGAP1	P46060	420	460	442	442	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15037602;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:15037602
RANGAP1	P46060	420	460	442	442	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15037602;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:15037602
RANGAP1	P46060	420	460	442	442	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15037602;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:15037602
RANGAP1	P46060	258	296	279	279	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RANGAP1	P46060	258	296	279	279	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RANGAP1	P46060	258	296	279	279	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RANGAP1	P46060	420	460	452	452	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RANGAP1	P46060	420	460	452	452	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RANGAP1	P46060	420	460	452	452	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RANGAP1	P46060	100	160	133	133	Natural variant	ID=VAR_029240;Note=E->Q;Dbxref=dbSNP:rs2229752
RANGAP1	P46060	100	160	133	133	Natural variant	ID=VAR_029240;Note=E->Q;Dbxref=dbSNP:rs2229752
RANGAP1	P46060	100	160	133	133	Natural variant	ID=VAR_029240;Note=E->Q;Dbxref=dbSNP:rs2229752
RANGAP1	P46060	80	100	91	91	Mutagenesis	Note=Abolishes RAN GTPase activation. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16428860;Dbxref=PMID:16428860
RANGAP1	P46060	80	100	91	91	Mutagenesis	Note=Abolishes RAN GTPase activation. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16428860;Dbxref=PMID:16428860
RANGAP1	P46060	80	100	91	91	Mutagenesis	Note=Abolishes RAN GTPase activation. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16428860;Dbxref=PMID:16428860
RANGAP1	P46060	420	460	434	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	434	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	434	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	443	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	443	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	443	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO2
RANGAP1	P46060	420	460	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO2
RANGAP1	P46060	420	460	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO2
RANGAP1	P46060	420	460	453	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	453	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANGAP1	P46060	420	460	453	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRR
RANBP1	P43487	146	168	2	201	Chain	ID=PRO_0000213667;Note=Ran-specific GTPase-activating protein
RANBP1	P43487	146	168	26	164	Domain	Note=RanBD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00164
RANBP1	P43487	146	168	150	150	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RANBP1	P43487	146	168	150	150	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P34022
RANBP1	P43487	146	168	145	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K5D
PHC1	P78364	38	75	1	1004	Chain	ID=PRO_0000058375;Note=Polyhomeotic-like protein 1
PHC1	P78364	102	152	1	1004	Chain	ID=PRO_0000058375;Note=Polyhomeotic-like protein 1
PHC1	P78364	152	204	1	1004	Chain	ID=PRO_0000058375;Note=Polyhomeotic-like protein 1
PHC1	P78364	38	75	1	1004	Chain	ID=PRO_0000058375;Note=Polyhomeotic-like protein 1
PHC1	P78364	102	152	1	1004	Chain	ID=PRO_0000058375;Note=Polyhomeotic-like protein 1
PHC1	P78364	152	204	1	1004	Chain	ID=PRO_0000058375;Note=Polyhomeotic-like protein 1
PHC1	P78364	152	204	165	167	Sequence conflict	Note=LGR->PGS;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHC1	P78364	152	204	165	167	Sequence conflict	Note=LGR->PGS;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHB	P35232	170	202	2	272	Chain	ID=PRO_0000213878;Note=Prohibitin
PHB	P35232	131	170	2	272	Chain	ID=PRO_0000213878;Note=Prohibitin
PHB	P35232	29	83	2	272	Chain	ID=PRO_0000213878;Note=Prohibitin
PHB	P35232	170	202	177	211	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHB	P35232	170	202	186	186	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67778
PHB	P35232	170	202	202	202	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PHB	P35232	170	202	202	202	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67778
PHB	P35232	170	202	140	256	Alternative sequence	ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PHB	P35232	131	170	140	256	Alternative sequence	ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PHKG2	P15735	109	130	1	406	Chain	ID=PRO_0000086512;Note=Phosphorylase b kinase gamma catalytic chain%2C liver/testis isoform
PHKG2	P15735	109	130	24	291	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PHKG2	P15735	109	130	115	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y7J
PHKG2	P15735	109	130	127	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y7J
PHLDB1	Q86UU1	61	118	1	1377	Chain	ID=PRO_0000053891;Note=Pleckstrin homology-like domain family B member 1
PHLDB1	Q86UU1	118	160	1	1377	Chain	ID=PRO_0000053891;Note=Pleckstrin homology-like domain family B member 1
PHLDB1	Q86UU1	747	793	1	1377	Chain	ID=PRO_0000053891;Note=Pleckstrin homology-like domain family B member 1
PHLDB1	Q86UU1	912	959	1	1377	Chain	ID=PRO_0000053891;Note=Pleckstrin homology-like domain family B member 1
PHLDB1	Q86UU1	1320	1331	1	1377	Chain	ID=PRO_0000053891;Note=Pleckstrin homology-like domain family B member 1
PHLDB1	Q86UU1	61	118	64	125	Domain	Note=FHA
PHLDB1	Q86UU1	118	160	64	125	Domain	Note=FHA
PHLDB1	Q86UU1	1320	1331	1256	1370	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PHLDB1	Q86UU1	747	793	683	809	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB1	Q86UU1	118	160	131	131	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6PDH0
PHLDB1	Q86UU1	912	959	913	959	Alternative sequence	ID=VSP_016737;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PHLDB1	Q86UU1	1320	1331	1043	1377	Alternative sequence	ID=VSP_016739;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHLDB1	Q86UU1	1320	1331	1321	1331	Alternative sequence	ID=VSP_016740;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RASAL1	O95294	458	504	1	804	Chain	ID=PRO_0000056645;Note=RasGAP-activating-like protein 1
RASAL1	O95294	41	78	1	804	Chain	ID=PRO_0000056645;Note=RasGAP-activating-like protein 1
RASAL1	O95294	22	40	1	804	Chain	ID=PRO_0000056645;Note=RasGAP-activating-like protein 1
RASAL1	O95294	41	78	1	88	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
RASAL1	O95294	22	40	1	88	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
RASAL1	O95294	458	504	301	511	Domain	Note=Ras-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00167
RASAL1	O95294	458	504	499	502	Compositional bias	Note=Poly-Leu
RASAL1	O95294	458	504	458	458	Alternative sequence	ID=VSP_047005;Note=In isoform 3. Q->QQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
RASAL1	O95294	41	78	58	58	Natural variant	ID=VAR_031666;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs34598602,PMID:15489334
RASA4	O43374	610	656	1	803	Chain	ID=PRO_0000056647;Note=Ras GTPase-activating protein 4
RASA4	O43374	610	656	566	673	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
RASA4	O43374	610	656	611	656	Alternative sequence	ID=VSP_039965;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PKN1	Q16512	323	388	2	942	Chain	ID=PRO_0000055719;Note=Serine/threonine-protein kinase N1
PKN1	Q16512	718	738	2	942	Chain	ID=PRO_0000055719;Note=Serine/threonine-protein kinase N1
PKN1	Q16512	323	388	325	461	Domain	Note=C2
PKN1	Q16512	718	738	615	874	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PKN1	Q16512	323	388	374	374	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63433
PKN1	Q16512	718	738	604	942	Alternative sequence	ID=VSP_039214;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PKN1	Q16512	718	738	718	718	Natural variant	ID=VAR_042343;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:7988719;Dbxref=dbSNP:rs2230539,PMID:17344846,PMID:7988719
PKN1	Q16512	718	738	736	736	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKN1	Q16512	718	738	714	733	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTH
PKN2	Q16513	328	390	1	984	Chain	ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2
PKN2	Q16513	427	475	1	984	Chain	ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2
PKN2	Q16513	701	759	1	984	Chain	ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2
PKN2	Q16513	760	780	1	984	Chain	ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2
PKN2	Q16513	854	890	1	984	Chain	ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2
PKN2	Q16513	328	390	330	463	Domain	Note=C2
PKN2	Q16513	427	475	330	463	Domain	Note=C2
PKN2	Q16513	701	759	657	916	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PKN2	Q16513	760	780	657	916	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PKN2	Q16513	854	890	657	916	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PKN2	Q16513	328	390	382	463	Region	Note=Necessary to rescue apical junction formation;Ontology_term=ECO:0000250;evidence=ECO:0000250
PKN2	Q16513	427	475	382	463	Region	Note=Necessary to rescue apical junction formation;Ontology_term=ECO:0000250;evidence=ECO:0000250
PKN2	Q16513	701	759	700	701	Site	Note=Cleavage%3B by caspase-3
PKN2	Q16513	328	390	360	360	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
PKN2	Q16513	328	390	362	362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PKN2	Q16513	328	390	327	329	Alternative sequence	ID=VSP_042182;Note=In isoform 5. LTG->MNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PKN2	Q16513	328	390	375	390	Alternative sequence	ID=VSP_042183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PKN2	Q16513	427	475	428	475	Alternative sequence	ID=VSP_042184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PKN2	Q16513	701	759	699	714	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	701	759	723	729	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	701	759	732	738	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	701	759	745	749	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	701	759	756	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	760	780	756	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	760	780	775	777	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	854	890	862	871	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN2	Q16513	854	890	882	891	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS
PKN3	Q6P5Z2	603	661	1	889	Chain	ID=PRO_0000055725;Note=Serine/threonine-protein kinase N3
PKN3	Q6P5Z2	662	682	1	889	Chain	ID=PRO_0000055725;Note=Serine/threonine-protein kinase N3
PKN3	Q6P5Z2	603	661	559	818	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PKN3	Q6P5Z2	662	682	559	818	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PKN3	Q6P5Z2	603	661	627	627	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKN3	Q6P5Z2	603	661	636	636	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHG1	Q9ULL1	469	482	1	1385	Chain	ID=PRO_0000080964;Note=Pleckstrin homology domain-containing family G member 1
PLEK2	Q9NYT0	257	285	1	353	Chain	ID=PRO_0000053862;Note=Pleckstrin-2
PLEK2	Q9NYT0	223	257	1	353	Chain	ID=PRO_0000053862;Note=Pleckstrin-2
PLEK2	Q9NYT0	223	257	139	225	Domain	Note=DEP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00066
PLEK2	Q9NYT0	257	285	247	353	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEK2	Q9NYT0	223	257	247	353	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEK2	Q9NYT0	257	285	246	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1G
PLEK2	Q9NYT0	223	257	246	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1G
PLEK2	Q9NYT0	257	285	259	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1G
PLEK2	Q9NYT0	257	285	277	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1G
PLEK2	Q9NYT0	257	285	283	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1G
PGF	P49763	131	202	19	221	Chain	ID=PRO_0000023420;Note=Placenta growth factor
PGF	P49763	131	202	193	213	Region	Note=Heparin-binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
PGF	P49763	131	202	132	203	Alternative sequence	ID=VSP_004644;Note=In isoform PlGF-1 and isoform PlGF-2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1924389,ECO:0000303|PubMed:8148155;Dbxref=PMID:15489334,PMID:1924389,PMID:8148155
PGF	P49763	131	202	116	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FZV
PLCD4	Q9BRC7	7	60	1	762	Chain	ID=PRO_0000306824;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase delta-4
PLCD4	Q9BRC7	373	424	1	762	Chain	ID=PRO_0000306824;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase delta-4
PLCD4	Q9BRC7	7	60	1	762	Chain	ID=PRO_0000306824;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase delta-4
PLCD4	Q9BRC7	373	424	1	762	Chain	ID=PRO_0000306824;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase delta-4
PLCD4	Q9BRC7	7	60	16	124	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLCD4	Q9BRC7	7	60	16	124	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLCD4	Q9BRC7	373	424	290	435	Domain	Note=PI-PLC X-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270
PLCD4	Q9BRC7	373	424	290	435	Domain	Note=PI-PLC X-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270
PLCD4	Q9BRC7	7	60	26	53	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
PLCD4	Q9BRC7	7	60	26	53	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
PLCD4	Q9BRC7	373	424	384	384	Metal binding	Note=Calcium 1%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
PLCD4	Q9BRC7	373	424	384	384	Metal binding	Note=Calcium 1%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
PLCD4	Q9BRC7	373	424	273	762	Alternative sequence	ID=VSP_028502;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15140260;Dbxref=PMID:15140260
PLCD4	Q9BRC7	373	424	273	762	Alternative sequence	ID=VSP_028502;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15140260;Dbxref=PMID:15140260
PLK4	O00444	42	74	1	970	Chain	ID=PRO_0000086567;Note=Serine/threonine-protein kinase PLK4
PLK4	O00444	42	74	12	265	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PLK4	O00444	42	74	45	45	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27796307;Dbxref=PMID:27796307
PLK4	O00444	42	74	46	46	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27796307;Dbxref=PMID:27796307
PLK4	O00444	42	74	43	74	Alternative sequence	ID=VSP_038117;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLK4	O00444	42	74	58	58	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLK4	O00444	42	74	37	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COK
PLK4	O00444	42	74	45	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COK
PLK4	O00444	42	74	54	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COK
PLG	P00747	601	625	20	810	Chain	ID=PRO_0000028053;Note=Plasminogen
PLG	P00747	626	672	20	810	Chain	ID=PRO_0000028053;Note=Plasminogen
PLG	P00747	601	625	581	810	Chain	ID=PRO_0000028058;Note=Plasmin light chain B
PLG	P00747	626	672	581	810	Chain	ID=PRO_0000028058;Note=Plasmin light chain B
PLG	P00747	601	625	581	808	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
PLG	P00747	626	672	581	808	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
PLG	P00747	601	625	622	622	Active site	Note=Charge relay system
PLG	P00747	626	672	665	665	Active site	Note=Charge relay system
PLG	P00747	601	625	567	685	Disulfide bond	Note=Interchain (between A and B chains)
PLG	P00747	626	672	567	685	Disulfide bond	Note=Interchain (between A and B chains)
PLG	P00747	601	625	607	623	Disulfide bond	.
PLG	P00747	601	625	620	620	Natural variant	ID=VAR_006629;Note=In PLGD%3B type 2 plasminogen deficiency%3B decreased activity%3B Nagoya-2/Tochigi/Kagoshima%3B may be associated with susceptibility to thrombosis. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1427790,ECO:0000269|PubMed:1986355,ECO:0000269|PubMed:6216475,ECO:0000269|PubMed:6238949;Dbxref=dbSNP:rs121918027,PMID:1427790,PMID:1986355,PMID:6216475,PMID:6238949
PLG	P00747	601	625	605	613	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	601	625	616	619	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	601	625	621	623	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	601	625	624	626	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	626	672	624	626	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	626	672	630	632	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	626	672	633	638	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	626	672	640	644	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	626	672	650	659	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLG	P00747	626	672	661	663	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QRZ
PLG	P00747	626	672	667	673	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UGG
PLOD3	O60568	645	687	25	738	Chain	ID=PRO_0000024686;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 3
PLOD3	O60568	596	645	25	738	Chain	ID=PRO_0000024686;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 3
PLOD3	O60568	293	335	25	738	Chain	ID=PRO_0000024686;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 3
PLOD3	O60568	645	687	647	738	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
PLOD3	O60568	645	687	667	667	Metal binding	Note=Iron;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
PLOD3	O60568	645	687	669	669	Metal binding	Note=Iron;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
PNPLA4	P41247	159	210	1	253	Chain	ID=PRO_0000058460;Note=Patatin-like phospholipase domain-containing protein 4
PNPLA4	P41247	137	159	1	253	Chain	ID=PRO_0000058460;Note=Patatin-like phospholipase domain-containing protein 4
PNPLA4	P41247	159	210	1	253	Chain	ID=PRO_0000058460;Note=Patatin-like phospholipase domain-containing protein 4
PNPLA4	P41247	137	159	1	253	Chain	ID=PRO_0000058460;Note=Patatin-like phospholipase domain-containing protein 4
PNPLA4	P41247	159	210	6	176	Domain	Note=PNPLA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	137	159	6	176	Domain	Note=PNPLA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	159	210	6	176	Domain	Note=PNPLA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	137	159	6	176	Domain	Note=PNPLA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	159	210	163	165	Motif	Note=DGA/G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	159	210	163	165	Motif	Note=DGA/G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	159	210	163	163	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	159	210	163	163	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01161
PNPLA4	P41247	159	210	187	187	Natural variant	ID=VAR_028070;Note=R->Q;Dbxref=dbSNP:rs2231793
PNPLA4	P41247	159	210	187	187	Natural variant	ID=VAR_028070;Note=R->Q;Dbxref=dbSNP:rs2231793
RAE1	P78406	30	65	1	368	Chain	ID=PRO_0000051181;Note=mRNA export factor
RAE1	P78406	275	340	1	368	Chain	ID=PRO_0000051181;Note=mRNA export factor
RAE1	P78406	30	65	1	368	Chain	ID=PRO_0000051181;Note=mRNA export factor
RAE1	P78406	275	340	1	368	Chain	ID=PRO_0000051181;Note=mRNA export factor
RAE1	P78406	30	65	1	368	Chain	ID=PRO_0000051181;Note=mRNA export factor
RAE1	P78406	275	340	1	368	Chain	ID=PRO_0000051181;Note=mRNA export factor
RAE1	P78406	30	65	37	79	Repeat	Note=WD 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	30	65	37	79	Repeat	Note=WD 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	30	65	37	79	Repeat	Note=WD 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	275	340	271	301	Repeat	Note=WD 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	275	340	271	301	Repeat	Note=WD 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	275	340	271	301	Repeat	Note=WD 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	275	340	310	346	Repeat	Note=WD 7;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	275	340	310	346	Repeat	Note=WD 7;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	275	340	310	346	Repeat	Note=WD 7;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:20498086;Dbxref=PMID:20498086
RAE1	P78406	30	65	31	31	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAE1	P78406	30	65	31	31	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAE1	P78406	30	65	31	31	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAE1	P78406	30	65	56	56	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAE1	P78406	30	65	56	56	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAE1	P78406	30	65	56	56	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAE1	P78406	30	65	42	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	42	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	42	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	52	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	52	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	52	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	64	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	64	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	30	65	64	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	276	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	276	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	276	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	283	285	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	283	285	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	283	285	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	288	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	288	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	288	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	297	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	297	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	297	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	302	305	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	302	305	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	302	305	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	306	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	306	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	306	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	318	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	318	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	318	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	330	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	330	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
RAE1	P78406	275	340	330	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MMY
FAM192A	Q9GZU8	42	75	1	254	Chain	ID=PRO_0000096847;Note=PSME3-interacting protein
FAM192A	Q9GZU8	42	75	1	254	Chain	ID=PRO_0000096847;Note=PSME3-interacting protein
FAM192A	Q9GZU8	42	75	1	254	Chain	ID=PRO_0000096847;Note=PSME3-interacting protein
FAM192A	Q9GZU8	42	75	1	254	Chain	ID=PRO_0000096847;Note=PSME3-interacting protein
FAM192A	Q9GZU8	42	75	1	254	Chain	ID=PRO_0000096847;Note=PSME3-interacting protein
PITPNM1	O00562	914	953	1	1244	Chain	ID=PRO_0000232738;Note=Membrane-associated phosphatidylinositol transfer protein 1
PITPNM1	O00562	322	354	1	1244	Chain	ID=PRO_0000232738;Note=Membrane-associated phosphatidylinositol transfer protein 1
PITPNM1	O00562	914	953	1	1244	Chain	ID=PRO_0000232738;Note=Membrane-associated phosphatidylinositol transfer protein 1
PITPNM1	O00562	322	354	1	1244	Chain	ID=PRO_0000232738;Note=Membrane-associated phosphatidylinositol transfer protein 1
PITPNM1	O00562	322	354	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35954
PITPNM1	O00562	322	354	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35954
PITPNM1	O00562	322	354	329	329	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35954
PITPNM1	O00562	322	354	329	329	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35954
PITPNM1	O00562	322	354	342	342	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U2N3
PITPNM1	O00562	322	354	342	342	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U2N3
PITPNM1	O00562	322	354	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U2N3
PITPNM1	O00562	322	354	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U2N3
PITPNM1	O00562	322	354	346	346	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U2N3
PITPNM1	O00562	322	354	346	346	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U2N3
PITPNM1	O00562	322	354	326	326	Mutagenesis	Note=No effect on phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15125835;Dbxref=PMID:15125835
PITPNM1	O00562	322	354	326	326	Mutagenesis	Note=No effect on phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15125835;Dbxref=PMID:15125835
PITPNM1	O00562	322	354	349	353	Mutagenesis	Note=Loss of interaction with VAPB. EFFDA->ALLAG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15545272;Dbxref=PMID:15545272
PITPNM1	O00562	322	354	349	353	Mutagenesis	Note=Loss of interaction with VAPB. EFFDA->ALLAG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15545272;Dbxref=PMID:15545272
PITPNM1	O00562	914	953	931	931	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PITPNM1	O00562	914	953	931	931	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PITPNM3	Q9BZ71	830	873	1	974	Chain	ID=PRO_0000232743;Note=Membrane-associated phosphatidylinositol transfer protein 3
PITPNM3	Q9BZ71	591	630	1	974	Chain	ID=PRO_0000232743;Note=Membrane-associated phosphatidylinositol transfer protein 3
PITPNM3	Q9BZ71	419	476	1	974	Chain	ID=PRO_0000232743;Note=Membrane-associated phosphatidylinositol transfer protein 3
PITPNM3	Q9BZ71	39	75	1	974	Chain	ID=PRO_0000232743;Note=Membrane-associated phosphatidylinositol transfer protein 3
PITPNM3	Q9BZ71	591	630	390	594	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
PITPNM3	Q9BZ71	419	476	390	594	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
PITPNM3	Q9BZ71	591	630	612	612	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PITPNM3	Q9BZ71	39	75	1	409	Alternative sequence	ID=VSP_017965;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PITPNM3	Q9BZ71	39	75	40	75	Alternative sequence	ID=VSP_046060;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PITPNM3	Q9BZ71	591	630	626	626	Natural variant	ID=VAR_046787;Note=In CORD5. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17377520;Dbxref=dbSNP:rs76024428,PMID:17377520
PIWIL4	Q7Z3Z4	55	99	1	852	Chain	ID=PRO_0000234572;Note=Piwi-like protein 4
PIWIL4	Q7Z3Z4	55	99	1	69	Alternative sequence	ID=VSP_036665;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIWIL4	Q7Z3Z4	55	99	78	78	Natural variant	ID=VAR_028367;Note=Q->R;Dbxref=dbSNP:rs12276921
PIWIL4	Q7Z3Z4	55	99	99	99	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHH2	Q8IVE3	738	767	1	1493	Chain	ID=PRO_0000307121;Note=Pleckstrin homology domain-containing family H member 2
PLEKHH2	Q8IVE3	738	767	703	797	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHH3	Q7Z736	518	671	19	793	Chain	ID=PRO_0000311108;Note=Pleckstrin homology domain-containing family H member 3
PLEKHH3	Q7Z736	518	671	404	754	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PLEKHH3	Q7Z736	518	671	638	638	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PLEKHH3	Q7Z736	518	671	642	642	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PLEKHH3	Q7Z736	518	671	514	531	Alternative sequence	ID=VSP_029393;Note=In isoform 4. FLFEQAHALLLRGRPPPP->RGHDFPPACSLGQDCSEI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHH3	Q7Z736	518	671	532	705	Alternative sequence	ID=VSP_029394;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHH3	Q7Z736	518	671	664	705	Alternative sequence	ID=VSP_029395;Note=In isoform 3. YDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVS->SLVGVLHRSCAWAWEPRPCPSPGQGRRSPSTVSAMAMWPPAS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHH3	Q7Z736	518	671	547	547	Natural variant	ID=VAR_061520;Note=Q->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs8071056,PMID:15489334
PLEKHA4	Q9H4M7	581	635	1	779	Chain	ID=PRO_0000053880;Note=Pleckstrin homology domain-containing family A member 4
PLEKHA4	Q9H4M7	442	475	1	779	Chain	ID=PRO_0000053880;Note=Pleckstrin homology domain-containing family A member 4
PLEKHA4	Q9H4M7	349	365	1	779	Chain	ID=PRO_0000053880;Note=Pleckstrin homology domain-containing family A member 4
PLEKHA4	Q9H4M7	324	349	1	779	Chain	ID=PRO_0000053880;Note=Pleckstrin homology domain-containing family A member 4
PLEKHA4	Q9H4M7	159	230	1	779	Chain	ID=PRO_0000053880;Note=Pleckstrin homology domain-containing family A member 4
PLEKHA4	Q9H4M7	28	64	1	779	Chain	ID=PRO_0000053880;Note=Pleckstrin homology domain-containing family A member 4
PLEKHA4	Q9H4M7	28	64	54	153	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHA4	Q9H4M7	349	365	162	353	Compositional bias	Note=Pro-rich
PLEKHA4	Q9H4M7	324	349	162	353	Compositional bias	Note=Pro-rich
PLEKHA4	Q9H4M7	159	230	162	353	Compositional bias	Note=Pro-rich
PLEKHA4	Q9H4M7	159	230	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PLEKHA4	Q9H4M7	349	365	325	349	Alternative sequence	ID=VSP_009770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHA4	Q9H4M7	324	349	325	349	Alternative sequence	ID=VSP_009770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHA4	Q9H4M7	581	635	582	608	Alternative sequence	ID=VSP_009771;Note=In isoform 2. APVARPRMSAQEQLERMRRNQECGRPF->SKEHHPLLADFRRSPGAGSQPLPSPGY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHA4	Q9H4M7	581	635	609	779	Alternative sequence	ID=VSP_009772;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHA4	Q9H4M7	28	64	37	37	Natural variant	ID=VAR_056667;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs506425,PMID:15489334
PLEKHA4	Q9H4M7	581	635	597	597	Natural variant	ID=VAR_056668;Note=R->Q;Dbxref=dbSNP:rs12460394
PLEKHA4	Q9H4M7	581	635	590	590	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHA4	Q9H4M7	28	64	55	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPQ
PIK3C3	Q8NEB9	569	613	1	887	Chain	ID=PRO_0000088802;Note=Phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3C3	Q8NEB9	729	754	1	887	Chain	ID=PRO_0000088802;Note=Phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3C3	Q8NEB9	841	883	1	887	Chain	ID=PRO_0000088802;Note=Phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3C3	Q8NEB9	729	754	631	885	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PIK3C3	Q8NEB9	841	883	631	885	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PIK3C3	Q8NEB9	729	754	750	750	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIK3C3	Q8NEB9	569	613	566	578	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	569	613	580	583	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	569	613	591	593	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	569	613	596	604	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	569	613	606	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	569	613	613	616	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PH4
PIK3C3	Q8NEB9	729	754	719	738	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	729	754	748	751	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	841	883	838	845	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	841	883	846	849	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PIK3C3	Q8NEB9	841	883	852	872	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UWH
PKP4	Q99569	1042	1085	1	1192	Chain	ID=PRO_0000064289;Note=Plakophilin-4
PKP4	Q99569	1042	1085	1045	1045	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FH0
PKP4	Q99569	1042	1085	1043	1085	Alternative sequence	ID=VSP_006737;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8937994;Dbxref=PMID:15489334,PMID:8937994
PLB1	Q6P1J6	522	544	22	1458	Chain	ID=PRO_0000324383;Note=Phospholipase B1%2C membrane-associated
PLB1	Q6P1J6	952	987	22	1458	Chain	ID=PRO_0000324383;Note=Phospholipase B1%2C membrane-associated
PLB1	Q6P1J6	987	1019	22	1458	Chain	ID=PRO_0000324383;Note=Phospholipase B1%2C membrane-associated
PLB1	Q6P1J6	1299	1334	22	1458	Chain	ID=PRO_0000324383;Note=Phospholipase B1%2C membrane-associated
PLB1	Q6P1J6	1366	1391	22	1458	Chain	ID=PRO_0000324383;Note=Phospholipase B1%2C membrane-associated
PLB1	Q6P1J6	522	544	22	1417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLB1	Q6P1J6	952	987	22	1417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLB1	Q6P1J6	987	1019	22	1417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLB1	Q6P1J6	1299	1334	22	1417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLB1	Q6P1J6	1366	1391	22	1417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLB1	Q6P1J6	522	544	362	707	Repeat	Note=2
PLB1	Q6P1J6	952	987	708	1054	Repeat	Note=3
PLB1	Q6P1J6	987	1019	708	1054	Repeat	Note=3
PLB1	Q6P1J6	1299	1334	1064	1402	Repeat	Note=4
PLB1	Q6P1J6	1366	1391	1064	1402	Repeat	Note=4
PLB1	Q6P1J6	522	544	39	1402	Region	Note=4 X 308-326 AA approximate repeats
PLB1	Q6P1J6	952	987	39	1402	Region	Note=4 X 308-326 AA approximate repeats
PLB1	Q6P1J6	987	1019	39	1402	Region	Note=4 X 308-326 AA approximate repeats
PLB1	Q6P1J6	1299	1334	39	1402	Region	Note=4 X 308-326 AA approximate repeats
PLB1	Q6P1J6	1366	1391	39	1402	Region	Note=4 X 308-326 AA approximate repeats
PLB1	Q6P1J6	522	544	529	529	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLB1	Q6P1J6	522	544	1	1035	Alternative sequence	ID=VSP_032225;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	952	987	1	1035	Alternative sequence	ID=VSP_032225;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	987	1019	1	1035	Alternative sequence	ID=VSP_032225;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	522	544	523	544	Alternative sequence	ID=VSP_032228;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	952	987	761	1458	Alternative sequence	ID=VSP_032230;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLB1	Q6P1J6	987	1019	761	1458	Alternative sequence	ID=VSP_032230;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLB1	Q6P1J6	1299	1334	761	1458	Alternative sequence	ID=VSP_032230;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLB1	Q6P1J6	1366	1391	761	1458	Alternative sequence	ID=VSP_032230;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLB1	Q6P1J6	952	987	801	1458	Alternative sequence	ID=VSP_032232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	987	1019	801	1458	Alternative sequence	ID=VSP_032232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	1299	1334	801	1458	Alternative sequence	ID=VSP_032232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	1366	1391	801	1458	Alternative sequence	ID=VSP_032232;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLB1	Q6P1J6	952	987	987	987	Natural variant	ID=VAR_061358;Note=A->V;Dbxref=dbSNP:rs34289907
PLB1	Q6P1J6	987	1019	987	987	Natural variant	ID=VAR_061358;Note=A->V;Dbxref=dbSNP:rs34289907
PLB1	Q6P1J6	1299	1334	1318	1318	Natural variant	ID=VAR_039797;Note=A->V;Dbxref=dbSNP:rs2199619
PLD1	Q13393	864	909	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	584	622	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	446	513	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	253	303	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	180	202	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	180	202	81	212	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
PLD1	Q13393	253	303	219	328	Domain	Note=PH
PLD1	Q13393	446	513	459	486	Domain	Note=PLD phosphodiesterase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00153
PLD1	Q13393	864	909	891	918	Domain	Note=PLD phosphodiesterase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00153
PLD1	Q13393	864	909	463	928	Region	Note=Catalytic
PLD1	Q13393	584	622	463	928	Region	Note=Catalytic
PLD1	Q13393	446	513	463	928	Region	Note=Catalytic
PLD1	Q13393	446	513	499	499	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70496
PLD1	Q13393	584	622	514	597	Alternative sequence	ID=VSP_005018;Note=In isoform PLD1C. PAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLI->IPGPSVVYRQVWESCMGKPDSGMERTTAISSSKTGFNLINLLLISLTGTPRPGCPGMTLPLQSTGRRLVMWHVTSSSAGTSQKL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD1	Q13393	584	622	585	623	Alternative sequence	ID=VSP_005020;Note=In isoform PLD1B. SYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHAD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9013646,ECO:0000303|PubMed:9761774;Dbxref=PMID:9013646,PMID:9761774
PLD1	Q13393	864	909	598	1074	Alternative sequence	ID=VSP_005019;Note=In isoform PLD1C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD1	Q13393	584	622	598	1074	Alternative sequence	ID=VSP_005019;Note=In isoform PLD1C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD1	Q13393	584	622	622	622	Natural variant	ID=VAR_022056;Note=A->S;Dbxref=dbSNP:rs2290480
PLBD2	Q8NHP8	128	181	42	589	Chain	ID=PRO_0000286110;Note=Putative phospholipase B-like 2
PLBD2	Q8NHP8	373	404	42	589	Chain	ID=PRO_0000286110;Note=Putative phospholipase B-like 2
PLBD2	Q8NHP8	405	428	42	589	Chain	ID=PRO_0000286110;Note=Putative phospholipase B-like 2
PLBD2	Q8NHP8	128	181	42	243	Chain	ID=PRO_0000314074;Note=Putative phospholipase B-like 2 32 kDa form
PLBD2	Q8NHP8	373	404	244	589	Chain	ID=PRO_0000314075;Note=Putative phospholipase B-like 2 45 kDa form
PLBD2	Q8NHP8	405	428	244	589	Chain	ID=PRO_0000314075;Note=Putative phospholipase B-like 2 45 kDa form
PLBD2	Q8NHP8	128	181	142	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLBD2	Q8NHP8	373	404	374	405	Alternative sequence	ID=VSP_055623;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLBD2	Q8NHP8	405	428	374	405	Alternative sequence	ID=VSP_055623;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGPAT2	O15120	164	196	24	278	Chain	ID=PRO_0000208192;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase beta
AGPAT2	O15120	164	196	24	278	Chain	ID=PRO_0000208192;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase beta
AGPAT2	O15120	164	196	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT2	O15120	164	196	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT2	O15120	164	196	172	175	Motif	Note=EGTR motif
AGPAT2	O15120	164	196	172	175	Motif	Note=EGTR motif
AGPAT2	O15120	164	196	165	196	Alternative sequence	ID=VSP_005071;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGPAT2	O15120	164	196	165	196	Alternative sequence	ID=VSP_005071;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLOD1	Q02809	247	281	19	727	Chain	ID=PRO_0000024678;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1
PLOD1	Q02809	401	442	19	727	Chain	ID=PRO_0000024678;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1
PLOD1	Q02809	490	528	19	727	Chain	ID=PRO_0000024678;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1
PLOD1	Q02809	528	550	19	727	Chain	ID=PRO_0000024678;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1
PLOD1	Q02809	550	585	19	727	Chain	ID=PRO_0000024678;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1
PLOD1	Q02809	585	634	19	727	Chain	ID=PRO_0000024678;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1
PLOD1	Q02809	528	550	538	538	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLOD1	Q02809	528	550	532	532	Natural variant	ID=VAR_006354;Note=In EDSKSCL1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8163671;Dbxref=PMID:8163671
PLOD1	Q02809	585	634	612	612	Natural variant	ID=VAR_006355;Note=In EDSKSCL1. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9617436;Dbxref=dbSNP:rs121913553,PMID:9617436
PLK3	Q9H4B4	106	145	1	646	Chain	ID=PRO_0000086564;Note=Serine/threonine-protein kinase PLK3
PLK3	Q9H4B4	419	447	1	646	Chain	ID=PRO_0000086564;Note=Serine/threonine-protein kinase PLK3
PLK3	Q9H4B4	106	145	62	314	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PLK3	Q9H4B4	419	447	419	419	Sequence conflict	Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLK3	Q9H4B4	106	145	101	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6L
PLK3	Q9H4B4	106	145	125	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6L
PLK3	Q9H4B4	106	145	132	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B6L
PLSCR1	O15162	192	246	1	318	Chain	ID=PRO_0000100784;Note=Phospholipid scramblase 1
PLSCR1	O15162	192	246	1	288	Topological domain	Note=Cytoplasmic
RCBTB2	O95199	225	261	1	551	Chain	ID=PRO_0000206644;Note=RCC1 and BTB domain-containing protein 2
RCBTB2	O95199	172	225	1	551	Chain	ID=PRO_0000206644;Note=RCC1 and BTB domain-containing protein 2
RCBTB2	O95199	172	225	171	222	Repeat	Note=RCC1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
RCBTB2	O95199	225	261	223	274	Repeat	Note=RCC1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
RCBTB2	O95199	172	225	223	274	Repeat	Note=RCC1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
RCC1	P18754	87	147	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	220	272	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	272	312	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	312	363	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	87	147	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	220	272	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	272	312	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	312	363	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	87	147	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	220	272	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	272	312	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	312	363	2	421	Chain	ID=PRO_0000206628;Note=Regulator of chromosome condensation
RCC1	P18754	87	147	85	136	Repeat	Note=RCC1 2
RCC1	P18754	87	147	85	136	Repeat	Note=RCC1 2
RCC1	P18754	87	147	85	136	Repeat	Note=RCC1 2
RCC1	P18754	87	147	138	189	Repeat	Note=RCC1 3
RCC1	P18754	87	147	138	189	Repeat	Note=RCC1 3
RCC1	P18754	87	147	138	189	Repeat	Note=RCC1 3
RCC1	P18754	220	272	191	257	Repeat	Note=RCC1 4
RCC1	P18754	220	272	191	257	Repeat	Note=RCC1 4
RCC1	P18754	220	272	191	257	Repeat	Note=RCC1 4
RCC1	P18754	220	272	258	311	Repeat	Note=RCC1 5
RCC1	P18754	272	312	258	311	Repeat	Note=RCC1 5
RCC1	P18754	220	272	258	311	Repeat	Note=RCC1 5
RCC1	P18754	272	312	258	311	Repeat	Note=RCC1 5
RCC1	P18754	220	272	258	311	Repeat	Note=RCC1 5
RCC1	P18754	272	312	258	311	Repeat	Note=RCC1 5
RCC1	P18754	272	312	312	362	Repeat	Note=RCC1 6
RCC1	P18754	312	363	312	362	Repeat	Note=RCC1 6
RCC1	P18754	272	312	312	362	Repeat	Note=RCC1 6
RCC1	P18754	312	363	312	362	Repeat	Note=RCC1 6
RCC1	P18754	272	312	312	362	Repeat	Note=RCC1 6
RCC1	P18754	312	363	312	362	Repeat	Note=RCC1 6
RCC1	P18754	312	363	363	416	Repeat	Note=RCC1 7
RCC1	P18754	312	363	363	416	Repeat	Note=RCC1 7
RCC1	P18754	312	363	363	416	Repeat	Note=RCC1 7
RCC1	P18754	87	147	88	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	88	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	88	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	121	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	121	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	121	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	128	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	128	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	128	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	87	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	220	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	220	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	220	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	242	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	242	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	242	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	251	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	251	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	251	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	261	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	261	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	220	272	261	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	280	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	296	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	296	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	296	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	303	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	303	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	272	312	303	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	315	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	315	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	315	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	322	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	322	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	322	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	328	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TBK
RCC1	P18754	312	363	328	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TBK
RCC1	P18754	312	363	328	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TBK
RCC1	P18754	312	363	335	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	335	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	335	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	343	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	343	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	343	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	354	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	354	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCC1	P18754	312	363	354	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A12
RCL1	Q9Y2P8	128	153	1	373	Chain	ID=PRO_0000156438;Note=RNA 3'-terminal phosphate cyclase-like protein
RCL1	Q9Y2P8	128	153	10	195	Alternative sequence	ID=VSP_056453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
RCL1	Q9Y2P8	128	153	153	153	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLXNA1	Q9UIW2	704	771	27	1896	Chain	ID=PRO_0000232745;Note=Plexin-A1
PLXNA1	Q9UIW2	704	771	27	1244	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA2	O75051	699	766	35	1894	Chain	ID=PRO_0000232747;Note=Plexin-A2
PLXNA2	O75051	457	502	35	1894	Chain	ID=PRO_0000232747;Note=Plexin-A2
PLXNA2	O75051	396	457	35	1894	Chain	ID=PRO_0000232747;Note=Plexin-A2
PLXNA2	O75051	699	766	35	1237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA2	O75051	457	502	35	1237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA2	O75051	396	457	35	1237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA2	O75051	457	502	35	508	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNA2	O75051	396	457	35	508	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNA2	O75051	699	766	756	756	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA2	O75051	396	457	284	405	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNA2	O75051	457	502	458	498	Alternative sequence	ID=VSP_017968;Note=In isoform 2. IRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVM->VRVYEFRCSNAIHLLSKESLLEGSYWWRFNYRQLYFLGEQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
PLXNA2	O75051	699	766	499	1894	Alternative sequence	ID=VSP_017969;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
PLXNA2	O75051	457	502	499	1894	Alternative sequence	ID=VSP_017969;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
PLXNA3	P51805	378	439	20	1871	Chain	ID=PRO_0000024670;Note=Plexin-A3
PLXNA3	P51805	1067	1147	20	1871	Chain	ID=PRO_0000024670;Note=Plexin-A3
PLXNA3	P51805	378	439	20	1220	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA3	P51805	1067	1147	20	1220	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA3	P51805	378	439	20	488	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNA3	P51805	1067	1147	1023	1122	Domain	Note=IPT/TIG 3
PLXNA3	P51805	1067	1147	1125	1211	Domain	Note=IPT/TIG 4
PLXNA3	P51805	1067	1147	1073	1073	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA3	P51805	1067	1147	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNA3	P51805	378	439	266	387	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNA3	P51805	378	439	384	384	Natural variant	ID=VAR_050595;Note=G->S;Dbxref=dbSNP:rs34585333
PLXNA3	P51805	378	439	413	413	Natural variant	ID=VAR_050596;Note=G->S;Dbxref=dbSNP:rs36115591
PCBD1	P61457	45	72	2	104	Chain	ID=PRO_0000063052;Note=Pterin-4-alpha-carbinolamine dehydratase
PCBD1	P61457	45	72	61	63	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
PIP5K1A	Q99755	40	52	1	562	Chain	ID=PRO_0000185456;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1A	Q99755	162	213	1	562	Chain	ID=PRO_0000185456;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1A	Q99755	382	409	1	562	Chain	ID=PRO_0000185456;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1A	Q99755	454	503	1	562	Chain	ID=PRO_0000185456;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1A	Q99755	162	213	81	449	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP5K1A	Q99755	382	409	81	449	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP5K1A	Q99755	454	503	486	486	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PIP5K1A	Q99755	40	52	30	52	Alternative sequence	ID=VSP_016007;Note=In isoform 2 and isoform 3. ASGIKRPMASEVLEARQDSYISL->SGIKRPMASE;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8955136;Dbxref=PMID:14702039,PMID:15489334,PMID:8955136
PIP5K1A	Q99755	40	52	41	52	Alternative sequence	ID=VSP_041912;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIP5K1A	Q99755	382	409	382	410	Alternative sequence	ID=VSP_041913;Note=In isoform 4. HMGGIPARNSKGERLLLYIGIIDILQSYR->Q;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIP5K1A	Q99755	454	503	455	504	Alternative sequence	ID=VSP_016008;Note=In isoform 2. LKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG->C;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8955136;Dbxref=PMID:15489334,PMID:8955136
PIP4K2A	P48426	213	226	2	406	Chain	ID=PRO_0000185465;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
PIP4K2A	P48426	164	213	2	406	Chain	ID=PRO_0000185465;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
PIP4K2A	P48426	113	164	2	406	Chain	ID=PRO_0000185465;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
PIP4K2A	P48426	213	226	33	405	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2A	P48426	164	213	33	405	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2A	P48426	113	164	33	405	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2A	P48426	113	164	145	145	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PIP4K2A	P48426	113	164	131	131	Mutagenesis	Note=Abolishes catalytic activity%3B when associated with F-138. G->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20583997;Dbxref=PMID:20583997
PIP4K2A	P48426	113	164	138	138	Mutagenesis	Note=Abolishes catalytic activity%3B when associated with L-131. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20583997;Dbxref=PMID:20583997
PIP4K2A	P48426	113	164	143	143	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIP4K2A	P48426	164	213	177	178	Sequence conflict	Note=QF->HL;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIP4K2A	P48426	113	164	109	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	113	164	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	113	164	140	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	164	213	149	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	113	164	149	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	164	213	169	171	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	164	213	178	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	164	213	189	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	164	213	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	164	213	207	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	213	226	215	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2A	P48426	213	226	223	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBX
PIP4K2C	Q8TBX8	123	171	2	421	Chain	ID=PRO_0000285750;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PIP4K2C	Q8TBX8	220	233	2	421	Chain	ID=PRO_0000285750;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PIP4K2C	Q8TBX8	123	171	2	421	Chain	ID=PRO_0000285750;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PIP4K2C	Q8TBX8	220	233	2	421	Chain	ID=PRO_0000285750;Note=Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PIP4K2C	Q8TBX8	123	171	43	420	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2C	Q8TBX8	220	233	43	420	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2C	Q8TBX8	123	171	43	420	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2C	Q8TBX8	220	233	43	420	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP4K2C	Q8TBX8	123	171	124	171	Alternative sequence	ID=VSP_042929;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIP4K2C	Q8TBX8	123	171	124	171	Alternative sequence	ID=VSP_042929;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIP4K2C	Q8TBX8	123	171	119	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK9
PIP4K2C	Q8TBX8	123	171	119	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK9
PIP4K2C	Q8TBX8	123	171	147	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK9
PIP4K2C	Q8TBX8	123	171	147	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK9
PIP4K2C	Q8TBX8	123	171	156	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK9
PIP4K2C	Q8TBX8	123	171	156	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK9
PIH1D1	Q9NWS0	229	277	1	290	Chain	ID=PRO_0000307328;Note=PIH1 domain-containing protein 1
PIH1D1	Q9NWS0	52	112	1	290	Chain	ID=PRO_0000307328;Note=PIH1 domain-containing protein 1
PIH1D1	Q9NWS0	229	277	1	290	Chain	ID=PRO_0000307328;Note=PIH1 domain-containing protein 1
PIH1D1	Q9NWS0	52	112	1	290	Chain	ID=PRO_0000307328;Note=PIH1 domain-containing protein 1
PIH1D1	Q9NWS0	52	112	57	57	Site	Note=Interacts with TELO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	57	57	Site	Note=Interacts with TELO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	64	64	Site	Note=Interacts with TELO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	64	64	Site	Note=Interacts with TELO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	229	277	31	290	Alternative sequence	ID=VSP_044424;Note=In isoform 2. ASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS->LSCIRIAPFEEQMRGLMAQTPSLEVVFLYTGLEGAPASPDNQTRIDTNPASAWFLHKDQLLGREGFHQHLPLPLYPSSRRRDRGGAASDARGGPSWVSHPHESGRASCRTGCKRPGMYRLRRSCQQRLLPEDAEQRFLAGARDHHRQGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIH1D1	Q9NWS0	52	112	31	290	Alternative sequence	ID=VSP_044424;Note=In isoform 2. ASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS->LSCIRIAPFEEQMRGLMAQTPSLEVVFLYTGLEGAPASPDNQTRIDTNPASAWFLHKDQLLGREGFHQHLPLPLYPSSRRRDRGGAASDARGGPSWVSHPHESGRASCRTGCKRPGMYRLRRSCQQRLLPEDAEQRFLAGARDHHRQGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIH1D1	Q9NWS0	229	277	31	290	Alternative sequence	ID=VSP_044424;Note=In isoform 2. ASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS->LSCIRIAPFEEQMRGLMAQTPSLEVVFLYTGLEGAPASPDNQTRIDTNPASAWFLHKDQLLGREGFHQHLPLPLYPSSRRRDRGGAASDARGGPSWVSHPHESGRASCRTGCKRPGMYRLRRSCQQRLLPEDAEQRFLAGARDHHRQGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIH1D1	Q9NWS0	52	112	31	290	Alternative sequence	ID=VSP_044424;Note=In isoform 2. ASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS->LSCIRIAPFEEQMRGLMAQTPSLEVVFLYTGLEGAPASPDNQTRIDTNPASAWFLHKDQLLGREGFHQHLPLPLYPSSRRRDRGGAASDARGGPSWVSHPHESGRASCRTGCKRPGMYRLRRSCQQRLLPEDAEQRFLAGARDHHRQGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIH1D1	Q9NWS0	229	277	113	290	Alternative sequence	ID=VSP_044425;Note=In isoform 3. KGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS->SQCPQRTQESGPLGPFFPRTQESWAQDPPPSAPGDLAPRSDSFPYGRSLVPWTSHTRAVLVLPPGQAGTFPCPTPGPGGLGRVLFVH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIH1D1	Q9NWS0	229	277	113	290	Alternative sequence	ID=VSP_044425;Note=In isoform 3. KGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS->SQCPQRTQESGPLGPFFPRTQESWAQDPPPSAPGDLAPRSDSFPYGRSLVPWTSHTRAVLVLPPGQAGTFPCPTPGPGGLGRVLFVH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIH1D1	Q9NWS0	229	277	230	230	Natural variant	ID=VAR_035413;Note=D->E;Dbxref=dbSNP:rs34198213
PIH1D1	Q9NWS0	229	277	230	230	Natural variant	ID=VAR_035413;Note=D->E;Dbxref=dbSNP:rs34198213
PIH1D1	Q9NWS0	52	112	54	54	Mutagenesis	Note=Abolishes binding to histone H4. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22368283;Dbxref=PMID:22368283
PIH1D1	Q9NWS0	52	112	54	54	Mutagenesis	Note=Abolishes binding to histone H4. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22368283;Dbxref=PMID:22368283
PIH1D1	Q9NWS0	52	112	55	55	Mutagenesis	Note=No effect on binding to histone H4. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22368283;Dbxref=PMID:22368283
PIH1D1	Q9NWS0	52	112	55	55	Mutagenesis	Note=No effect on binding to histone H4. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22368283;Dbxref=PMID:22368283
PIH1D1	Q9NWS0	52	112	57	57	Mutagenesis	Note=Abolishes binding to TELO2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	57	57	Mutagenesis	Note=Abolishes binding to TELO2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	64	64	Mutagenesis	Note=Abolishes binding to ECD%2C EFTUD2%2C RPB1%2C TELO2 and UBR5. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	64	64	Mutagenesis	Note=Abolishes binding to ECD%2C EFTUD2%2C RPB1%2C TELO2 and UBR5. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24656813;Dbxref=PMID:24656813
PIH1D1	Q9NWS0	52	112	102	102	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIH1D1	Q9NWS0	52	112	102	102	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIH1D1	Q9NWS0	52	112	51	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	51	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	61	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	61	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	83	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	83	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	107	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D1	Q9NWS0	52	112	107	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PSF
PIH1D2	Q8WWB5	100	182	1	315	Chain	ID=PRO_0000307334;Note=PIH1 domain-containing protein 2
PIH1D2	Q8WWB5	100	182	1	315	Chain	ID=PRO_0000307334;Note=PIH1 domain-containing protein 2
PIH1D2	Q8WWB5	100	182	117	117	Natural variant	ID=VAR_035415;Note=A->V;Dbxref=dbSNP:rs1425917
PIH1D2	Q8WWB5	100	182	117	117	Natural variant	ID=VAR_035415;Note=A->V;Dbxref=dbSNP:rs1425917
PLEKHG4	Q58EX7	166	198	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	503	564	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	814	844	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	918	975	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	1073	1151	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	166	198	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	503	564	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	814	844	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	918	975	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	1073	1151	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	166	198	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	503	564	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	814	844	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	918	975	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	1073	1151	1	1191	Chain	ID=PRO_0000224996;Note=Puratrophin-1
PLEKHG4	Q58EX7	814	844	732	908	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG4	Q58EX7	814	844	732	908	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG4	Q58EX7	814	844	732	908	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG4	Q58EX7	918	975	920	1027	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHG4	Q58EX7	918	975	920	1027	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHG4	Q58EX7	918	975	920	1027	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHG4	Q58EX7	166	198	118	198	Alternative sequence	ID=VSP_017329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHG4	Q58EX7	166	198	118	198	Alternative sequence	ID=VSP_017329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHG4	Q58EX7	166	198	118	198	Alternative sequence	ID=VSP_017329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHG4	Q58EX7	166	198	167	193	Alternative sequence	ID=VSP_017330;Note=In isoform 3. APSGSGLPKPADCLLAQDLCWELLASG->GKEGWAREVWEGNGDAWRDECQDFGGL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	166	198	167	193	Alternative sequence	ID=VSP_017330;Note=In isoform 3. APSGSGLPKPADCLLAQDLCWELLASG->GKEGWAREVWEGNGDAWRDECQDFGGL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	166	198	167	193	Alternative sequence	ID=VSP_017330;Note=In isoform 3. APSGSGLPKPADCLLAQDLCWELLASG->GKEGWAREVWEGNGDAWRDECQDFGGL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	166	198	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	503	564	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	814	844	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	918	975	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	1073	1151	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	166	198	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	503	564	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	814	844	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	918	975	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	1073	1151	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	166	198	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	503	564	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	814	844	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	918	975	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	1073	1151	194	1191	Alternative sequence	ID=VSP_017331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16001362;Dbxref=PMID:16001362
PLEKHG4	Q58EX7	503	564	525	525	Natural variant	ID=VAR_050510;Note=D->G;Dbxref=dbSNP:rs8044843
PLEKHG4	Q58EX7	503	564	525	525	Natural variant	ID=VAR_050510;Note=D->G;Dbxref=dbSNP:rs8044843
PLEKHG4	Q58EX7	503	564	525	525	Natural variant	ID=VAR_050510;Note=D->G;Dbxref=dbSNP:rs8044843
PLEKHG4	Q58EX7	814	844	830	830	Natural variant	ID=VAR_050511;Note=R->H;Dbxref=dbSNP:rs3868142
PLEKHG4	Q58EX7	814	844	830	830	Natural variant	ID=VAR_050511;Note=R->H;Dbxref=dbSNP:rs3868142
PLEKHG4	Q58EX7	814	844	830	830	Natural variant	ID=VAR_050511;Note=R->H;Dbxref=dbSNP:rs3868142
PLEKHG4	Q58EX7	1073	1151	1090	1090	Natural variant	ID=VAR_050512;Note=S->T;Dbxref=dbSNP:rs17680862
PLEKHG4	Q58EX7	1073	1151	1090	1090	Natural variant	ID=VAR_050512;Note=S->T;Dbxref=dbSNP:rs17680862
PLEKHG4	Q58EX7	1073	1151	1090	1090	Natural variant	ID=VAR_050512;Note=S->T;Dbxref=dbSNP:rs17680862
PLEKHG4	Q58EX7	1073	1151	1134	1134	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHG4	Q58EX7	1073	1151	1134	1134	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHG4	Q58EX7	1073	1151	1134	1134	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHA1	Q9HB21	204	227	1	404	Chain	ID=PRO_0000053873;Note=Pleckstrin homology domain-containing family A member 1
PLEKHA1	Q9HB21	270	300	1	404	Chain	ID=PRO_0000053873;Note=Pleckstrin homology domain-containing family A member 1
PLEKHA1	Q9HB21	204	227	1	404	Chain	ID=PRO_0000053873;Note=Pleckstrin homology domain-containing family A member 1
PLEKHA1	Q9HB21	270	300	1	404	Chain	ID=PRO_0000053873;Note=Pleckstrin homology domain-containing family A member 1
PLEKHA1	Q9HB21	204	227	191	289	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHA1	Q9HB21	270	300	191	289	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHA1	Q9HB21	204	227	191	289	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHA1	Q9HB21	270	300	191	289	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHA1	Q9HB21	204	227	203	205	Mutagenesis	Note=Abolishes phosphatidylinositide binding. AVM->GGG
PLEKHA1	Q9HB21	204	227	203	205	Mutagenesis	Note=Abolishes phosphatidylinositide binding. AVM->GGG
PLEKHA1	Q9HB21	204	227	203	205	Mutagenesis	Note=Binds both PtdIns3%2C4P2 and PtdIns3%2C4%2C5P3. AVM->GLV
PLEKHA1	Q9HB21	204	227	203	205	Mutagenesis	Note=Binds both PtdIns3%2C4P2 and PtdIns3%2C4%2C5P3. AVM->GLV
PLEKHA1	Q9HB21	204	227	203	204	Mutagenesis	Note=Binds both PtdIns3%2C4P2 and PtdIns3%2C4%2C5P3. AV->GG
PLEKHA1	Q9HB21	204	227	203	204	Mutagenesis	Note=Binds both PtdIns3%2C4P2 and PtdIns3%2C4%2C5P3. AV->GG
PLEKHA1	Q9HB21	204	227	204	204	Mutagenesis	Note=No effect. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513726;Dbxref=PMID:11513726
PLEKHA1	Q9HB21	204	227	204	204	Mutagenesis	Note=No effect. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513726;Dbxref=PMID:11513726
PLEKHA1	Q9HB21	204	227	205	205	Mutagenesis	Note=No effect. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513726;Dbxref=PMID:11513726
PLEKHA1	Q9HB21	204	227	205	205	Mutagenesis	Note=No effect. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513726;Dbxref=PMID:11513726
PLEKHA1	Q9HB21	204	227	207	207	Mutagenesis	Note=No effect. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513726;Dbxref=PMID:11513726
PLEKHA1	Q9HB21	204	227	207	207	Mutagenesis	Note=No effect. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513726;Dbxref=PMID:11513726
PLEKHA1	Q9HB21	204	227	211	211	Mutagenesis	Note=Abolishes phosphatidylinositide binding. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11001876;Dbxref=PMID:11001876
PLEKHA1	Q9HB21	204	227	211	211	Mutagenesis	Note=Abolishes phosphatidylinositide binding. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11001876;Dbxref=PMID:11001876
PLEKHA1	Q9HB21	204	227	203	205	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	204	227	203	205	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	204	227	208	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	204	227	208	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	204	227	217	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	204	227	217	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	270	300	266	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	270	300	266	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	270	300	274	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA1	Q9HB21	270	300	274	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EAZ
PLEKHA7	Q6IQ23	719	769	1	1121	Chain	ID=PRO_0000287692;Note=Pleckstrin homology domain-containing family A member 7
PLEKHA7	Q6IQ23	622	651	1	1121	Chain	ID=PRO_0000287692;Note=Pleckstrin homology domain-containing family A member 7
PLEKHA7	Q6IQ23	291	447	1	1121	Chain	ID=PRO_0000287692;Note=Pleckstrin homology domain-containing family A member 7
PLEKHA7	Q6IQ23	74	101	1	1121	Chain	ID=PRO_0000287692;Note=Pleckstrin homology domain-containing family A member 7
PLEKHA7	Q6IQ23	74	101	54	87	Domain	Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
PLEKHA7	Q6IQ23	622	651	538	696	Region	Note=Interaction with CTNND1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19041755;Dbxref=PMID:19041755
PLEKHA7	Q6IQ23	719	769	700	801	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PLEKHA7	Q6IQ23	291	447	1	447	Alternative sequence	ID=VSP_039543;Note=In isoform 3. MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSR->MFPKACRTLAWLPDPFLPFLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHA7	Q6IQ23	74	101	1	447	Alternative sequence	ID=VSP_039543;Note=In isoform 3. MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSR->MFPKACRTLAWLPDPFLPFLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHO1	Q53GL0	59	106	1	409	Chain	ID=PRO_0000310423;Note=Pleckstrin homology domain-containing family O member 1
PLEKHO1	Q53GL0	106	141	1	409	Chain	ID=PRO_0000310423;Note=Pleckstrin homology domain-containing family O member 1
PLEKHO1	Q53GL0	141	175	1	409	Chain	ID=PRO_0000310423;Note=Pleckstrin homology domain-containing family O member 1
PLEKHO1	Q53GL0	59	106	21	132	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHO1	Q53GL0	106	141	21	132	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHO1	Q53GL0	106	141	133	193	Region	Note=Interaction with capping proteins (CPs)
PLEKHO1	Q53GL0	141	175	133	193	Region	Note=Interaction with capping proteins (CPs)
PLEKHO1	Q53GL0	106	141	136	308	Region	Note=Interaction with ATM%2C CKIP%2C IFP35 and NMI;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16325375,ECO:0000269|PubMed:17197158;Dbxref=PMID:16325375,PMID:17197158
PLEKHO1	Q53GL0	141	175	136	308	Region	Note=Interaction with ATM%2C CKIP%2C IFP35 and NMI;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16325375,ECO:0000269|PubMed:17197158;Dbxref=PMID:16325375,PMID:17197158
PLEKHO1	Q53GL0	141	175	155	155	Binding site	Note=Capping protein
PLEKHO1	Q53GL0	141	175	157	157	Binding site	Note=Capping protein
PLEKHO1	Q53GL0	141	175	142	175	Alternative sequence	ID=VSP_029282;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHO1	Q53GL0	106	141	123	123	Mutagenesis	Note=Disruption of membrane localization and impaired interaction with CK2. Loss of phospholipid binding%3B when associated with C-42. Loss of phospholipid binding%3B when associated with C-44. Disruption of membrane localization%2C loss of phospholipid binding and impaired interaction with CK2%3B when associated with C-42 and C-44. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15254037;Dbxref=PMID:15254037
PLEKHO1	Q53GL0	106	141	133	133	Mutagenesis	Note=No effect on binding to capping proteins and loss of phospholipid binding%3B when associated with A-135 and A-137. R->A
PLEKHO1	Q53GL0	106	141	133	133	Mutagenesis	Note=No effect on binding to capping proteins%3B when associated with E-135. R->E
PLEKHO1	Q53GL0	106	141	135	135	Mutagenesis	Note=No effect on binding to capping proteins%3B when associated with A-133 and A-137. K->A
PLEKHO1	Q53GL0	106	141	135	135	Mutagenesis	Note=No effect on binding to capping proteins%3B when associated with E-133. K->E
PLEKHO1	Q53GL0	106	141	137	137	Mutagenesis	Note=No effect on binding to capping proteins%3B when associated with A-133 and A-135. R->A
PLEKHO1	Q53GL0	141	175	155	155	Mutagenesis	Note=No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins%3B when associated with A-157. Great loss of binding to capping proteins%3B when associated with A-157 and A-159. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987810;Dbxref=PMID:16987810
PLEKHO1	Q53GL0	141	175	155	155	Mutagenesis	Note=No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins and no change in cell morphology and actin cytoskeleton%3B when associated with E-157. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987810;Dbxref=PMID:16987810
PLEKHO1	Q53GL0	141	175	157	157	Mutagenesis	Note=No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins%3B when associated with A-155. Great loss of binding to capping proteins%3B when associated with A-155 and A-159. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987810;Dbxref=PMID:16987810
PLEKHO1	Q53GL0	141	175	157	157	Mutagenesis	Note=No change in cell morphology and actin cytoskeleton. Great loss of binding to capping proteins and no change in cell morphology and actin cytoskeleton%3B when associated with E-155. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987810;Dbxref=PMID:16987810
PLEKHO1	Q53GL0	141	175	159	159	Mutagenesis	Note=Great loss of binding to capping proteins%3B when associated with A-155 and A-157. K->A
PLEKHO1	Q53GL0	141	175	153	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AA1
PKHD1	P08F94	3799	3835	24	4074	Chain	ID=PRO_0000022062;Note=Fibrocystin
PKHD1	P08F94	2724	2767	24	4074	Chain	ID=PRO_0000022062;Note=Fibrocystin
PKHD1	P08F94	2702	2724	24	4074	Chain	ID=PRO_0000022062;Note=Fibrocystin
PKHD1	P08F94	3799	3835	24	3858	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1	P08F94	2724	2767	24	3858	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1	P08F94	2702	2724	24	3858	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1	P08F94	2724	2767	2747	2873	Domain	Note=G8 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00817
PKHD1	P08F94	2724	2767	2753	2753	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1	P08F94	3799	3835	3397	4074	Alternative sequence	ID=VSP_003948;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12079288;Dbxref=PMID:12079288
PKHD1	P08F94	3799	3835	496	4074	Natural variant	ID=VAR_080923;Note=Found in a patient affected by polycystic liver disease%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PKHD1	P08F94	2724	2767	496	4074	Natural variant	ID=VAR_080923;Note=Found in a patient affected by polycystic liver disease%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PKHD1	P08F94	2702	2724	496	4074	Natural variant	ID=VAR_080923;Note=Found in a patient affected by polycystic liver disease%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PKHD1	P08F94	2724	2767	2761	2761	Natural variant	ID=VAR_018567;Note=In PKD4. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12506140;Dbxref=PMID:12506140
PKHD1	P08F94	3799	3835	3070	4074	Natural variant	ID=VAR_080927;Note=Probable disease-associated mutation found in a patient affected by polycystic liver disease. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PKHD1	P08F94	3799	3835	3407	4074	Natural variant	ID=VAR_080930;Note=Found in a patient affected by polycystic liver disease%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
PKD2	Q13563	365	439	1	968	Chain	ID=PRO_0000164356;Note=Polycystin-2
PKD2	Q13563	516	572	1	968	Chain	ID=PRO_0000164356;Note=Polycystin-2
PKD2	Q13563	673	706	1	968	Chain	ID=PRO_0000164356;Note=Polycystin-2
PKD2	Q13563	365	439	242	468	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	516	572	506	526	Transmembrane	Note=Helical%3B Name%3DS3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	516	572	527	552	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	516	572	553	573	Transmembrane	Note=Helical%3B Name%3DS4;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	673	706	655	675	Transmembrane	Note=Helical%3B Name%3DS6;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	673	706	676	968	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	365	439	375	375	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27768895,ECO:0000269|PubMed:27991905,ECO:0000269|PubMed:28092368;Dbxref=PMID:27768895,PMID:27991905,PMID:28092368
PKD2	Q13563	516	572	484	968	Alternative sequence	ID=VSP_042480;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKD2	Q13563	673	706	484	968	Alternative sequence	ID=VSP_042480;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKD2	Q13563	516	572	517	572	Alternative sequence	ID=VSP_042481;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKD2	Q13563	673	706	647	968	Alternative sequence	ID=VSP_042483;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKD2	Q13563	365	439	384	384	Natural variant	ID=VAR_064394;Note=In PKD2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21115670;Dbxref=PMID:21115670
PKD2	Q13563	365	439	414	414	Natural variant	ID=VAR_009195;Note=In PKD2%3B affects channel activity as it is able to abolish channel currents induced by the gain-of-function artificial mutant P-604. W->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12707387,ECO:0000269|PubMed:27071085,ECO:0000269|PubMed:9326320;Dbxref=PMID:12707387,PMID:27071085,PMID:9326320
PKD2	Q13563	365	439	420	420	Natural variant	ID=VAR_058825;Note=In PKD2%3B affects channel activity as it is able to abolish channel currents induced by the gain-of-function artificial mutant P-604. R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14993477,ECO:0000269|PubMed:27071085;Dbxref=PMID:14993477,PMID:27071085
PKD2	Q13563	673	706	684	684	Natural variant	ID=VAR_011076;Note=In PKD2%3B somatic mutation. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10835625;Dbxref=PMID:10835625
PKD2	Q13563	365	439	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	365	439	371	373	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	365	439	390	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	365	439	399	411	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	365	439	419	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	365	439	431	434	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	365	439	435	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	516	572	506	527	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	516	572	528	530	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	516	572	533	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	516	572	549	571	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	516	572	572	579	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PKD2	Q13563	673	706	673	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T4D
PLBD1	Q6P4A8	112	139	39	553	Chain	ID=PRO_0000286106;Note=Phospholipase B-like 1
PLBD1	Q6P4A8	112	139	39	208	Chain	ID=PRO_0000425421;Note=Phospholipase B-like 1 chain A
PLBD1	Q6P4A8	112	139	93	208	Chain	ID=PRO_0000425422;Note=Phospholipase B-like 1 chain C
PLIN2	Q99541	259	304	2	437	Chain	ID=PRO_0000099888;Note=Perilipin-2
RB1	P06400	405	444	2	928	Chain	ID=PRO_0000167836;Note=Retinoblastoma-associated protein
RB1	P06400	444	463	2	928	Chain	ID=PRO_0000167836;Note=Retinoblastoma-associated protein
RB1	P06400	702	737	2	928	Chain	ID=PRO_0000167836;Note=Retinoblastoma-associated protein
RB1	P06400	737	775	2	928	Chain	ID=PRO_0000167836;Note=Retinoblastoma-associated protein
RB1	P06400	405	444	373	771	Region	Note=Pocket%3B binds T and E1A
RB1	P06400	444	463	373	771	Region	Note=Pocket%3B binds T and E1A
RB1	P06400	702	737	373	771	Region	Note=Pocket%3B binds T and E1A
RB1	P06400	737	775	373	771	Region	Note=Pocket%3B binds T and E1A
RB1	P06400	405	444	373	579	Region	Note=Domain A
RB1	P06400	444	463	373	579	Region	Note=Domain A
RB1	P06400	702	737	640	771	Region	Note=Domain B
RB1	P06400	737	775	640	771	Region	Note=Domain B
RB1	P06400	737	775	763	928	Region	Note=Interaction with LIMD1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15542589;Dbxref=PMID:15542589
RB1	P06400	737	775	771	928	Region	Note=Domain C%3B mediates interaction with E4F1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10869426;Dbxref=PMID:10869426
RB1	P06400	405	444	436	436	Natural variant	ID=VAR_019379;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7;Dbxref=dbSNP:rs4151534
RB1	P06400	444	463	447	447	Natural variant	ID=VAR_010048;Note=In RB. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9140452;Dbxref=PMID:9140452
RB1	P06400	444	463	457	457	Natural variant	ID=VAR_005576;Note=In RB. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8346255;Dbxref=PMID:8346255
RB1	P06400	702	737	706	706	Natural variant	ID=VAR_005586;Note=In RB. C->Y
RB1	P06400	702	737	712	712	Natural variant	ID=VAR_005587;Note=In RB. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671068;Dbxref=dbSNP:rs137853296,PMID:10671068
RB1	P06400	737	775	746	746	Natural variant	ID=VAR_034442;Note=E->G;Dbxref=dbSNP:rs3092905
RB1	P06400	405	444	398	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	405	444	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	405	444	412	434	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	405	444	436	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	405	444	439	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	444	463	439	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	702	737	700	714	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	702	737	721	728	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	702	737	731	733	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N4M
RB1	P06400	702	737	737	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	737	775	737	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	737	775	741	743	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	737	775	745	747	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	737	775	748	750	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ELJ
RB1	P06400	737	775	752	758	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	737	775	760	770	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RB1	P06400	737	775	773	775	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R7G
RC3H1	Q5TC82	987	1045	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	790	841	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	445	538	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	987	1045	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	790	841	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	445	538	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	445	538	533	788	Compositional bias	Note=Pro-rich
RC3H1	Q5TC82	445	538	533	788	Compositional bias	Note=Pro-rich
RC3H1	Q5TC82	445	538	510	510	Site	Note=Cleavage%3B by MALT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	510	510	Site	Note=Cleavage%3B by MALT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RC3H1	Q5TC82	445	538	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RC3H1	Q5TC82	445	538	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
RC3H1	Q5TC82	445	538	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
RC3H1	Q5TC82	987	1045	988	996	Alternative sequence	ID=VSP_015015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RC3H1	Q5TC82	987	1045	988	996	Alternative sequence	ID=VSP_015015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RCBTB1	Q8NDN9	201	237	1	531	Chain	ID=PRO_0000206642;Note=RCC1 and BTB domain-containing protein 1
RCBTB1	Q8NDN9	201	237	1	531	Chain	ID=PRO_0000206642;Note=RCC1 and BTB domain-containing protein 1
RCBTB1	Q8NDN9	201	237	199	250	Repeat	Note=RCC1 4
RCBTB1	Q8NDN9	201	237	199	250	Repeat	Note=RCC1 4
RCN2	Q14257	149	187	23	317	Chain	ID=PRO_0000004148;Note=Reticulocalbin-2
RCN2	Q14257	149	187	150	185	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RCN2	Q14257	149	187	186	221	Domain	Note=EF-hand 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RCN2	Q14257	149	187	162	173	Calcium binding	Note=3%3B possibly ancestral;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RCN2	Q14257	149	187	149	149	Alternative sequence	ID=VSP_055139;Note=In isoform 2. K->KEFAICKKQSFCFWLLRFN;Ontology_term=ECO:0000305;evidence=ECO:0000305
PNO1	Q9NRX1	119	147	1	252	Chain	ID=PRO_0000270540;Note=RNA-binding protein PNO1
INPP5J	Q15735	498	537	1	1006	Chain	ID=PRO_0000209738;Note=Phosphatidylinositol 4%2C5-bisphosphate 5-phosphatase A
INPP5J	Q15735	731	777	1	1006	Chain	ID=PRO_0000209738;Note=Phosphatidylinositol 4%2C5-bisphosphate 5-phosphatase A
INPP5J	Q15735	777	803	1	1006	Chain	ID=PRO_0000209738;Note=Phosphatidylinositol 4%2C5-bisphosphate 5-phosphatase A
INPP5J	Q15735	803	838	1	1006	Chain	ID=PRO_0000209738;Note=Phosphatidylinositol 4%2C5-bisphosphate 5-phosphatase A
INPP5J	Q15735	498	537	425	728	Region	Note=Catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255
INPP5J	Q15735	731	777	729	840	Region	Note=Required for ruffle localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP5J	Q15735	777	803	729	840	Region	Note=Required for ruffle localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP5J	Q15735	803	838	729	840	Region	Note=Required for ruffle localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
INPP5J	Q15735	777	803	791	791	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIAS2	O75928	242	287	1	621	Chain	ID=PRO_0000218976;Note=E3 SUMO-protein ligase PIAS2
PIAS2	O75928	242	287	134	299	Domain	Note=PINIT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00799
PIAS2	O75928	242	287	249	249	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
PIAS2	O75928	242	287	264	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO9
PIAS2	O75928	242	287	271	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO9
PIAS2	O75928	242	287	275	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO9
PIGQ	Q9BRB3	230	273	2	760	Chain	ID=PRO_0000215664;Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
PIGQ	Q9BRB3	445	472	2	760	Chain	ID=PRO_0000215664;Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
PIGQ	Q9BRB3	445	472	446	468	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGQ	Q9BRB3	230	273	214	536	Compositional bias	Note=Leu-rich
PIGQ	Q9BRB3	445	472	214	536	Compositional bias	Note=Leu-rich
PIGQ	Q9BRB3	445	472	300	760	Alternative sequence	ID=VSP_007280;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PIGR	P01833	14	129	1	18	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1859628,ECO:0000269|PubMed:6526384;Dbxref=PMID:1859628,PMID:6526384
PIGR	P01833	348	459	19	764	Chain	ID=PRO_0000014900;Note=Polymeric immunoglobulin receptor
PIGR	P01833	14	129	19	764	Chain	ID=PRO_0000014900;Note=Polymeric immunoglobulin receptor
PIGR	P01833	348	459	19	603	Chain	ID=PRO_0000014901;Note=Secretory component
PIGR	P01833	14	129	19	603	Chain	ID=PRO_0000014901;Note=Secretory component
PIGR	P01833	348	459	19	638	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGR	P01833	14	129	19	638	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGR	P01833	14	129	19	120	Domain	Note=Ig-like V-type 1
PIGR	P01833	348	459	250	352	Domain	Note=Ig-like V-type 3
PIGR	P01833	348	459	364	458	Domain	Note=Ig-like V-type 4
PIGR	P01833	14	129	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:6526384;Dbxref=PMID:15084671,PMID:16740002,PMID:18780401,PMID:6526384
PIGR	P01833	14	129	90	90	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:6526384;Dbxref=PMID:15084671,PMID:16335952,PMID:16740002,PMID:18780401,PMID:6526384
PIGR	P01833	348	459	421	421	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6526384;Dbxref=PMID:15084671,PMID:16335952,PMID:16740002,PMID:18780401,PMID:19159218,PMID:6526384
PIGR	P01833	14	129	40	110	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:6526384;Dbxref=PMID:6526384
PIGR	P01833	14	129	56	64	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:6526384;Dbxref=PMID:6526384
PIGR	P01833	348	459	371	441	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:6526384;Dbxref=PMID:6526384
PIGR	P01833	348	459	385	395	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:6526384;Dbxref=PMID:6526384
PIGR	P01833	348	459	365	365	Natural variant	ID=VAR_025283;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1355431,ECO:0000269|PubMed:1682231,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:1859628,ECO:0000269|PubMed:2920039,ECO:0000269|PubMed:6526384;Dbxref=dbSNP:rs2275531,PMID:1355431,PMID:1682231,PMID:17974005,PMID:1859628,PMID:2920039,PMID:6526384
PIGR	P01833	348	459	392	392	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGR	P01833	348	459	392	392	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGR	P01833	14	129	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	36	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	46	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	53	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	60	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	65	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	76	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	88	91	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	92	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	106	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	14	129	120	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XED
PIGR	P01833	348	459	357	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	365	372	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	375	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	383	386	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	390	392	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	397	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	407	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	410	412	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	413	419	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	421	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	433	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	437	442	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PIGR	P01833	348	459	451	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D4K
PI4KB	Q9UBF8	507	541	2	816	Chain	ID=PRO_0000088829;Note=Phosphatidylinositol 4-kinase beta
PI4KB	Q9UBF8	394	470	2	816	Chain	ID=PRO_0000088829;Note=Phosphatidylinositol 4-kinase beta
PI4KB	Q9UBF8	303	318	2	816	Chain	ID=PRO_0000088829;Note=Phosphatidylinositol 4-kinase beta
PI4KB	Q9UBF8	394	470	428	428	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PI4KB	Q9UBF8	394	470	438	438	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11277933;Dbxref=PMID:11277933
PI4KB	Q9UBF8	507	541	511	511	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:11277933;Dbxref=PMID:18220336,PMID:18669648,PMID:23186163,PMID:11277933
PI4KB	Q9UBF8	507	541	517	517	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PI4KB	Q9UBF8	507	541	519	519	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11277933;Dbxref=PMID:11277933
PI4KB	Q9UBF8	303	318	1	332	Alternative sequence	ID=VSP_037133;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PI4KB	Q9UBF8	303	318	304	318	Alternative sequence	ID=VSP_050627;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9020160,ECO:0000303|PubMed:9405935;Dbxref=PMID:15489334,PMID:9020160,PMID:9405935
PI4KB	Q9UBF8	394	470	446	446	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PI4KB	Q9UBF8	394	470	392	394	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WAE
PI4KB	Q9UBF8	394	470	397	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C46
PI4KB	Q9UBF8	394	470	409	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C46
PI4KB	Q9UBF8	507	541	537	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C46
PIM2	Q9P1W9	198	257	1	311	Chain	ID=PRO_0000086532;Note=Serine/threonine-protein kinase pim-2
PIM2	Q9P1W9	198	257	32	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PIM2	Q9P1W9	198	257	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q
PIM2	Q9P1W9	198	257	206	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q
PIM2	Q9P1W9	198	257	216	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q
PIM2	Q9P1W9	198	257	241	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q
PIM2	Q9P1W9	198	257	257	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7Q
RBL1	P28749	957	1012	1	1068	Chain	ID=PRO_0000167839;Note=Retinoblastoma-like protein 1
RBL1	P28749	853	877	1	1068	Chain	ID=PRO_0000167839;Note=Retinoblastoma-like protein 1
RBL1	P28749	794	853	1	1068	Chain	ID=PRO_0000167839;Note=Retinoblastoma-like protein 1
RBL1	P28749	634	723	1	1068	Chain	ID=PRO_0000167839;Note=Retinoblastoma-like protein 1
RBL1	P28749	535	590	1	1068	Chain	ID=PRO_0000167839;Note=Retinoblastoma-like protein 1
RBL1	P28749	853	877	385	949	Region	Note=Pocket%3B binds T and E1A
RBL1	P28749	794	853	385	949	Region	Note=Pocket%3B binds T and E1A
RBL1	P28749	634	723	385	949	Region	Note=Pocket%3B binds T and E1A
RBL1	P28749	535	590	385	949	Region	Note=Pocket%3B binds T and E1A
RBL1	P28749	535	590	385	584	Region	Note=Domain A
RBL1	P28749	634	723	585	780	Region	Note=Spacer
RBL1	P28749	535	590	585	780	Region	Note=Spacer
RBL1	P28749	853	877	781	949	Region	Note=Domain B
RBL1	P28749	794	853	781	949	Region	Note=Domain B
RBL1	P28749	634	723	640	640	Modified residue	Note=Phosphoserine%3B by CDK2 and CDK4;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:11884610;Dbxref=PMID:23186163,PMID:11884610
RBL1	P28749	634	723	650	650	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006580;Dbxref=PMID:12006580
RBL1	P28749	957	1012	964	964	Modified residue	Note=Phosphoserine%3B by CDK2 and CDK4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	957	1012	975	975	Modified residue	Note=Phosphoserine%3B by CDK2 and CDK4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	957	1012	988	988	Modified residue	Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:11884610;Dbxref=PMID:23186163,PMID:11884610
RBL1	P28749	957	1012	997	997	Modified residue	Note=Phosphothreonine%3B by CDK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	957	1012	1009	1009	Modified residue	Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	634	723	640	640	Mutagenesis	Note=Strongly reduces phosphorylation by CDK2 and CDK4. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	634	723	643	643	Mutagenesis	Note=No effect on S-640 phosphorylation%2C but strongly increases S-640 phosphorylation%3B when associated with 657-A--A-660. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	634	723	650	650	Mutagenesis	Note=No effect on phosphorylation by CDK2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	634	723	657	660	Mutagenesis	Note=Reduces S-640 phosphorylation by CDK2 and CDK4. KRRL->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11884610;Dbxref=PMID:11884610
RBL1	P28749	535	590	535	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	535	590	549	564	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	535	590	566	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	535	590	573	580	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	535	590	581	583	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	535	590	588	591	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	794	853	785	809	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	794	853	814	830	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	794	853	832	835	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	853	877	840	854	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	794	853	840	854	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	853	877	855	857	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOS
RBL1	P28749	853	877	861	868	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	853	877	877	880	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YOZ
RBL1	P28749	957	1012	1001	1005	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TUV
RBL1	P28749	957	1012	1006	1008	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TUV
RBL1	P28749	957	1012	1011	1023	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TUV
PITHD1	Q9GZP4	81	106	1	211	Chain	ID=PRO_0000285032;Note=PITH domain-containing protein 1
PITHD1	Q9GZP4	81	106	20	192	Domain	Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864
PJA2	O43164	490	550	2	708	Chain	ID=PRO_0000278230;Note=E3 ubiquitin-protein ligase Praja-2
PJA2	O43164	10	77	2	708	Chain	ID=PRO_0000278230;Note=E3 ubiquitin-protein ligase Praja-2
PJA2	O43164	490	550	2	708	Chain	ID=PRO_0000278230;Note=E3 ubiquitin-protein ligase Praja-2
PJA2	O43164	10	77	2	708	Chain	ID=PRO_0000278230;Note=E3 ubiquitin-protein ligase Praja-2
PJA2	O43164	490	550	531	708	Region	Note=Interaction with PRKAR1A%2C PRKAR2A and PRKAR2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21423175;Dbxref=PMID:21423175
PJA2	O43164	490	550	531	708	Region	Note=Interaction with PRKAR1A%2C PRKAR2A and PRKAR2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21423175;Dbxref=PMID:21423175
PJA2	O43164	490	550	544	563	Alternative sequence	ID=VSP_023198;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PJA2	O43164	490	550	544	563	Alternative sequence	ID=VSP_023198;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PLEKHG4B	Q96PX9	279	308	1	1271	Chain	ID=PRO_0000317286;Note=Pleckstrin homology domain-containing family G member 4B
PLEKHG4B	Q96PX9	887	917	1	1271	Chain	ID=PRO_0000317286;Note=Pleckstrin homology domain-containing family G member 4B
PLEKHG4B	Q96PX9	887	917	805	984	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHN1	Q494U1	384	431	2	611	Chain	ID=PRO_0000309363;Note=Pleckstrin homology domain-containing family N member 1
PLEKHN1	Q494U1	431	478	2	611	Chain	ID=PRO_0000309363;Note=Pleckstrin homology domain-containing family N member 1
PLEKHN1	Q494U1	431	478	456	456	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18191643;Dbxref=PMID:18191643
PLEKHN1	Q494U1	384	431	385	431	Alternative sequence	ID=VSP_059840;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHN1	Q494U1	431	478	385	431	Alternative sequence	ID=VSP_059840;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHN1	Q494U1	431	478	456	456	Mutagenesis	Note=Loss of phosphorylation and interaction with C1QBP%3B when associated with F-302. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18191643;Dbxref=PMID:18191643
PLEKHG2	Q9H7P9	472	530	1	1386	Chain	ID=PRO_0000306861;Note=Pleckstrin homology domain-containing family G member 2
PLEKHG2	Q9H7P9	472	530	468	496	Alternative sequence	ID=VSP_028529;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLA1A	Q53H76	187	221	26	456	Chain	ID=PRO_0000273330;Note=Phospholipase A1 member A
PLA1A	Q53H76	221	251	26	456	Chain	ID=PRO_0000273330;Note=Phospholipase A1 member A
PLA1A	Q53H76	251	307	26	456	Chain	ID=PRO_0000273330;Note=Phospholipase A1 member A
PLA1A	Q53H76	187	221	190	190	Active site	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10037
PLA1A	Q53H76	251	307	260	260	Active site	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10037
PLA1A	Q53H76	221	251	245	258	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLA1A	Q53H76	251	307	245	258	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLA1A	Q53H76	251	307	282	293	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLA1A	Q53H76	251	307	296	304	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLA1A	Q53H76	251	307	284	284	Natural variant	ID=VAR_030128;Note=S->N;Dbxref=dbSNP:rs2692622
PLA1A	Q53H76	187	221	213	213	Sequence conflict	Note=V->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLA2R1	Q13018	1236	1283	21	1463	Chain	ID=PRO_5000144349;Note=Secretory phospholipase A2 receptor
PLA2R1	Q13018	800	812	21	1463	Chain	ID=PRO_5000144349;Note=Secretory phospholipase A2 receptor
PLA2R1	Q13018	222	280	21	1463	Chain	ID=PRO_5000144349;Note=Secretory phospholipase A2 receptor
PLA2R1	Q13018	1236	1283	21	1397	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLA2R1	Q13018	800	812	21	1397	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLA2R1	Q13018	222	280	21	1397	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLA2R1	Q13018	222	280	238	355	Domain	Note=C-type lectin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
PLA2R1	Q13018	1236	1283	1257	1378	Domain	Note=C-type lectin 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
PLA2R1	Q13018	222	280	260	354	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLA2R1	Q13018	1236	1283	1280	1377	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PLA2R1	Q13018	222	280	279	279	Natural variant	ID=VAR_037205;Note=I->V;Dbxref=dbSNP:rs965290
PLA2R1	Q13018	1236	1283	1263	1263	Sequence conflict	Note=S->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
JUP	P14923	551	591	1	745	Chain	ID=PRO_0000064278;Note=Junction plakoglobin
JUP	P14923	386	499	1	745	Chain	ID=PRO_0000064278;Note=Junction plakoglobin
JUP	P14923	551	591	1	745	Chain	ID=PRO_0000064278;Note=Junction plakoglobin
JUP	P14923	386	499	1	745	Chain	ID=PRO_0000064278;Note=Junction plakoglobin
JUP	P14923	551	591	1	745	Chain	ID=PRO_0000064278;Note=Junction plakoglobin
JUP	P14923	386	499	1	745	Chain	ID=PRO_0000064278;Note=Junction plakoglobin
JUP	P14923	386	499	383	420	Repeat	Note=ARM 7
JUP	P14923	386	499	383	420	Repeat	Note=ARM 7
JUP	P14923	386	499	383	420	Repeat	Note=ARM 7
JUP	P14923	386	499	423	464	Repeat	Note=ARM 8
JUP	P14923	386	499	423	464	Repeat	Note=ARM 8
JUP	P14923	386	499	423	464	Repeat	Note=ARM 8
JUP	P14923	386	499	470	510	Repeat	Note=ARM 9
JUP	P14923	386	499	470	510	Repeat	Note=ARM 9
JUP	P14923	386	499	470	510	Repeat	Note=ARM 9
JUP	P14923	551	591	512	551	Repeat	Note=ARM 10
JUP	P14923	551	591	512	551	Repeat	Note=ARM 10
JUP	P14923	551	591	512	551	Repeat	Note=ARM 10
JUP	P14923	551	591	574	613	Repeat	Note=ARM 11
JUP	P14923	551	591	574	613	Repeat	Note=ARM 11
JUP	P14923	551	591	574	613	Repeat	Note=ARM 11
JUP	P14923	551	591	574	661	Region	Note=Interaction with DSC1
JUP	P14923	551	591	574	661	Region	Note=Interaction with DSC1
JUP	P14923	551	591	574	661	Region	Note=Interaction with DSC1
JUP	P14923	386	499	390	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	390	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	390	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	398	401	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	398	401	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	398	401	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	405	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	405	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	405	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	419	421	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	419	421	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	419	421	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	423	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	423	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	423	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	430	433	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	430	433	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	430	433	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	434	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	434	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	434	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	449	462	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	449	462	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	449	462	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	464	466	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	464	466	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	464	466	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	469	477	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	469	477	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	469	477	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	478	480	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	478	480	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	478	480	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	481	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	481	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	481	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	488	490	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	488	490	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	488	490	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	495	508	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	495	508	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	386	499	495	508	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	556	570	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	556	570	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	556	570	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	574	582	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	574	582	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	574	582	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	586	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	586	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
JUP	P14923	551	591	586	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IFQ
PLXDC1	Q8IUK5	395	407	19	500	Chain	ID=PRO_0000232751;Note=Plexin domain-containing protein 1
PLXDC1	Q8IUK5	270	302	19	500	Chain	ID=PRO_0000232751;Note=Plexin domain-containing protein 1
PLXDC1	Q8IUK5	85	133	19	500	Chain	ID=PRO_0000232751;Note=Plexin domain-containing protein 1
PLXDC1	Q8IUK5	395	407	19	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXDC1	Q8IUK5	270	302	19	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXDC1	Q8IUK5	85	133	19	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXDC1	Q8IUK5	395	407	338	500	Alternative sequence	ID=VSP_017973;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15574754;Dbxref=PMID:15574754
PLXDC1	Q8IUK5	395	407	359	500	Alternative sequence	ID=VSP_017974;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15574754;Dbxref=PMID:15574754
AGPAT3	Q9NRZ7	116	170	1	376	Chain	ID=PRO_0000208194;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
AGPAT3	Q9NRZ7	116	170	1	376	Chain	ID=PRO_0000208194;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
AGPAT3	Q9NRZ7	116	170	1	376	Chain	ID=PRO_0000208194;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
AGPAT3	Q9NRZ7	116	170	1	376	Chain	ID=PRO_0000208194;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
AGPAT3	Q9NRZ7	116	170	1	376	Chain	ID=PRO_0000208194;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
AGPAT3	Q9NRZ7	116	170	1	376	Chain	ID=PRO_0000208194;Note=1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
AGPAT3	Q9NRZ7	116	170	1	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	1	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	1	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	1	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	1	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	1	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	146	316	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	146	316	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	146	316	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	146	316	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	146	316	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGPAT3	Q9NRZ7	116	170	146	316	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMFBP1	Q8TBY8	903	927	1	1022	Chain	ID=PRO_0000304619;Note=Polyamine-modulated factor 1-binding protein 1
PMFBP1	Q8TBY8	812	868	1	1022	Chain	ID=PRO_0000304619;Note=Polyamine-modulated factor 1-binding protein 1
PMFBP1	Q8TBY8	138	212	1	1022	Chain	ID=PRO_0000304619;Note=Polyamine-modulated factor 1-binding protein 1
PMFBP1	Q8TBY8	55	138	1	1022	Chain	ID=PRO_0000304619;Note=Polyamine-modulated factor 1-binding protein 1
PMFBP1	Q8TBY8	55	138	75	107	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PMFBP1	Q8TBY8	138	212	155	206	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PMFBP1	Q8TBY8	812	868	761	868	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PMFBP1	Q8TBY8	903	927	926	961	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PMFBP1	Q8TBY8	138	212	1	145	Alternative sequence	ID=VSP_045353;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMFBP1	Q8TBY8	55	138	1	145	Alternative sequence	ID=VSP_045353;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMFBP1	Q8TBY8	138	212	172	172	Natural variant	ID=VAR_035042;Note=A->T;Dbxref=dbSNP:rs217180
PMFBP1	Q8TBY8	138	212	193	193	Natural variant	ID=VAR_035043;Note=E->K;Dbxref=dbSNP:rs35370634
PMFBP1	Q8TBY8	903	927	918	918	Natural variant	ID=VAR_069056;Note=K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11230166,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs16973716,PMID:11230166,PMID:14702039
PNPT1	Q8TCS8	716	732	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	607	635	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	534	558	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	480	498	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	172	188	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	607	635	605	664	Domain	Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PNPT1	Q8TCS8	716	732	679	750	Domain	Note=S1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180
PNPT1	Q8TCS8	534	558	552	552	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K1R3
PNPT1	Q8TCS8	480	498	484	484	Mutagenesis	Note=Inhibits poly(A) polymerase and RNA degradation activities. Does not inhibit the import or stabilization of RNase P RNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904
PNPT1	Q8TCS8	534	558	544	544	Mutagenesis	Note=Stimulates in vitro poly(A) polymerase activity. Inhibits RNA degradation activity. Inhibits the import or stabilization of RNase P RNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904
PNPT1	Q8TCS8	172	188	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	172	188	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	480	498	483	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	534	558	535	539	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	534	558	541	549	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	534	558	554	561	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	606	611	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	614	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	623	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	626	635	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
POF1B	Q8WVV4	479	522	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	350	388	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	319	350	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	180	241	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	146	180	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	119	146	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	94	119	1	589	Chain	ID=PRO_0000253911;Note=Protein POF1B
POF1B	Q8WVV4	350	388	334	443	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
POF1B	Q8WVV4	319	350	334	443	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
POF1B	Q8WVV4	479	522	307	589	Alternative sequence	ID=VSP_021150;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POF1B	Q8WVV4	350	388	307	589	Alternative sequence	ID=VSP_021150;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POF1B	Q8WVV4	319	350	307	589	Alternative sequence	ID=VSP_021150;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
POF1B	Q8WVV4	180	241	207	207	Natural variant	ID=VAR_028753;Note=P->S;Dbxref=dbSNP:rs363766
POF1B	Q8WVV4	180	241	239	239	Natural variant	ID=VAR_028754;Note=C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15459172;Dbxref=dbSNP:rs147563033,PMID:15459172
POF1B	Q8WVV4	319	350	323	323	Natural variant	ID=VAR_028756;Note=M->V;Dbxref=dbSNP:rs363775
POF1B	Q8WVV4	319	350	329	329	Natural variant	ID=VAR_028757;Note=In POF2B%3B disrupts binding to nonmuscle actin filaments%3B abolishes tight junction localization%3B altered ciliogenesis and cystogenesis. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15459172,ECO:0000269|PubMed:16773570,ECO:0000269|PubMed:21940798;Dbxref=dbSNP:rs75398746,PMID:15459172,PMID:16773570,PMID:21940798
POF1B	Q8WVV4	319	350	349	349	Natural variant	ID=VAR_028758;Note=M->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15459172,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs363774,PMID:14702039,PMID:15459172,PMID:15489334
POF1B	Q8WVV4	180	241	180	180	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
POF1B	Q8WVV4	146	180	180	180	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
POF1B	Q8WVV4	479	522	503	503	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLI	Q9UNA4	80	135	1	740	Chain	ID=PRO_0000173988;Note=DNA polymerase iota
POLI	Q9UNA4	135	186	1	740	Chain	ID=PRO_0000173988;Note=DNA polymerase iota
POLI	Q9UNA4	186	265	1	740	Chain	ID=PRO_0000173988;Note=DNA polymerase iota
POLI	Q9UNA4	80	135	55	268	Domain	Note=UmuC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
POLI	Q9UNA4	135	186	55	268	Domain	Note=UmuC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
POLI	Q9UNA4	186	265	55	268	Domain	Note=UmuC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
POLI	Q9UNA4	135	186	152	152	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00216
POLI	Q9UNA4	135	186	151	151	Metal binding	Note=Magnesium
POLI	Q9UNA4	80	135	96	96	Binding site	Note=dNTP
POLI	Q9UNA4	80	135	96	96	Natural variant	ID=VAR_021239;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs3218778
POLI	Q9UNA4	186	265	261	261	Natural variant	ID=VAR_021240;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs3218784
POLI	Q9UNA4	80	135	80	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	80	135	87	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	80	135	93	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	80	135	97	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	80	135	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H4D
POLI	Q9UNA4	80	135	106	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	80	135	113	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FLN
POLI	Q9UNA4	80	135	117	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	80	135	125	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	125	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	145	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	149	151	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	152	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	158	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	170	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	173	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	135	186	183	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	193	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	228	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EPG
POLI	Q9UNA4	186	265	239	241	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EPG
POLI	Q9UNA4	186	265	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	248	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	251	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
POLI	Q9UNA4	186	265	261	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OSN
PKHD1L1	Q86WI1	657	695	21	4243	Chain	ID=PRO_0000318572;Note=Fibrocystin-L
PKHD1L1	Q86WI1	4161	4240	21	4243	Chain	ID=PRO_0000318572;Note=Fibrocystin-L
PKHD1L1	Q86WI1	657	695	21	4210	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1L1	Q86WI1	4161	4240	21	4210	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1L1	Q86WI1	4161	4240	4211	4231	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1L1	Q86WI1	4161	4240	4232	4243	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKHD1L1	Q86WI1	4161	4240	4188	4200	Compositional bias	Note=Poly-Ser
PKHD1L1	Q86WI1	4161	4240	4220	4220	Natural variant	ID=VAR_038774;Note=V->I;Dbxref=dbSNP:rs1783174
PLEKHB1	Q9UF11	31	82	1	243	Chain	ID=PRO_0000053886;Note=Pleckstrin homology domain-containing family B member 1
PLEKHB1	Q9UF11	130	165	1	243	Chain	ID=PRO_0000053886;Note=Pleckstrin homology domain-containing family B member 1
PLEKHB1	Q9UF11	31	82	21	128	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHB1	Q9UF11	130	165	131	165	Alternative sequence	ID=VSP_009780;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10585447,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10585447,PMID:14702039,PMID:15489334
PLD2	O14939	236	286	1	933	Chain	ID=PRO_0000218805;Note=Phospholipase D2
PLD2	O14939	287	336	1	933	Chain	ID=PRO_0000218805;Note=Phospholipase D2
PLD2	O14939	567	605	1	933	Chain	ID=PRO_0000218805;Note=Phospholipase D2
PLD2	O14939	605	640	1	933	Chain	ID=PRO_0000218805;Note=Phospholipase D2
PLD2	O14939	670	707	1	933	Chain	ID=PRO_0000218805;Note=Phospholipase D2
PLD2	O14939	236	286	203	311	Domain	Note=PH
PLD2	O14939	287	336	203	311	Domain	Note=PH
PLD2	O14939	567	605	441	788	Region	Note=Catalytic
PLD2	O14939	605	640	441	788	Region	Note=Catalytic
PLD2	O14939	670	707	441	788	Region	Note=Catalytic
PLD2	O14939	567	605	337	933	Alternative sequence	ID=VSP_005027;Note=In isoform PLD2C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD2	O14939	605	640	337	933	Alternative sequence	ID=VSP_005027;Note=In isoform PLD2C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD2	O14939	670	707	337	933	Alternative sequence	ID=VSP_005027;Note=In isoform PLD2C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD2	O14939	567	605	577	577	Natural variant	ID=VAR_051705;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9582313;Dbxref=dbSNP:rs1052748,PMID:15489334,PMID:9582313
PLD2	O14939	605	640	632	632	Natural variant	ID=VAR_061750;Note=E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs17854914,PMID:15489334
PLD2	O14939	236	286	268	268	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLD2	O14939	287	336	325	325	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLCB2	Q00722	867	882	1	1185	Chain	ID=PRO_0000088489;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-2
PLCB2	Q00722	775	810	1	1185	Chain	ID=PRO_0000088489;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-2
PLCB2	Q00722	151	168	1	1185	Chain	ID=PRO_0000088489;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-2
PLCB2	Q00722	77	124	1	1185	Chain	ID=PRO_0000088489;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-2
PLCB2	Q00722	867	882	868	882	Alternative sequence	ID=VSP_054490;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLCB2	Q00722	77	124	119	119	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLCB2	Q00722	77	124	79	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	77	124	85	88	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FJU
PLCB2	Q00722	77	124	94	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	77	124	98	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	77	124	105	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	77	124	111	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	77	124	122	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	151	168	144	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	151	168	167	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	775	810	776	783	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB2	Q00722	775	810	789	802	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZKM
PLCB3	Q01970	82	129	2	1234	Chain	ID=PRO_0000088491;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-3
PLCB3	Q01970	33	59	2	1234	Chain	ID=PRO_0000088491;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-3
PLCB3	Q01970	82	129	2	1234	Chain	ID=PRO_0000088491;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase beta-3
PLCB3	Q01970	82	129	33	99	Alternative sequence	ID=VSP_046054;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLCB3	Q01970	33	59	33	99	Alternative sequence	ID=VSP_046054;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLCB3	Q01970	82	129	33	99	Alternative sequence	ID=VSP_046054;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLCB3	Q01970	33	59	33	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QJ3
PLCB3	Q01970	33	59	40	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	33	59	51	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	33	59	57	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	84	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	84	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	97	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QJ3
PLCB3	Q01970	82	129	97	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QJ3
PLCB3	Q01970	82	129	103	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	103	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	112	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	112	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	116	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	116	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	127	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCB3	Q01970	82	129	127	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OHM
PLCD1	P51178	379	429	1	756	Chain	ID=PRO_0000088504;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase delta-1
PLCD1	P51178	379	429	296	440	Domain	Note=PI-PLC X-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270
PLCD1	P51178	379	429	390	390	Metal binding	Note=Calcium 1%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
RCCD1	A6NED2	259	316	1	376	Chain	ID=PRO_0000337973;Note=RCC1 domain-containing protein 1
RCCD1	A6NED2	259	316	1	376	Chain	ID=PRO_0000337973;Note=RCC1 domain-containing protein 1
RCCD1	A6NED2	259	316	229	317	Repeat	Note=RCC1 3
RCCD1	A6NED2	259	316	229	317	Repeat	Note=RCC1 3
PLXNB3	Q9ULL4	15	362	1	44	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB3	Q9ULL4	15	362	45	1909	Chain	ID=PRO_0000024674;Note=Plexin-B3
PLXNB3	Q9ULL4	422	465	45	1909	Chain	ID=PRO_0000024674;Note=Plexin-B3
PLXNB3	Q9ULL4	15	362	45	1255	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB3	Q9ULL4	422	465	45	1255	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB3	Q9ULL4	15	362	45	471	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	422	465	45	471	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	15	362	51	51	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB3	Q9ULL4	15	362	231	231	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB3	Q9ULL4	15	362	98	107	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	15	362	132	140	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	15	362	267	370	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	15	362	283	315	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	15	362	333	357	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNB3	Q9ULL4	15	362	1	15	Alternative sequence	ID=VSP_044467;Note=In isoform 2. MCHAAQETPLLHHFM->MELTPASSLTCSLLSPRLPGSFPQLRRVPPCSRPWLPK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLXNB3	Q9ULL4	15	362	126	126	Natural variant	ID=VAR_050601;Note=A->T;Dbxref=dbSNP:rs34360382
PLXNB3	Q9ULL4	15	362	149	149	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLXNB3	Q9ULL4	15	362	300	300	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLXNB2	O15031	1414	1463	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	696	727	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	662	696	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	1414	1463	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	696	727	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	662	696	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	696	727	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	662	696	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	696	727	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	662	696	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	1414	1463	1219	1838	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	1414	1463	1219	1838	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	1414	1463	1462	1469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E71
PLXNB2	O15031	1414	1463	1462	1469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E71
PMEL	P40967	451	490	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	156	210	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	62	111	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	25	62	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	451	490	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	156	210	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	62	111	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	25	62	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	451	490	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	156	210	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	62	111	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	25	62	25	661	Chain	ID=PRO_0000024712;Note=Melanocyte protein PMEL
PMEL	P40967	451	490	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	156	210	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	62	111	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	25	62	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	451	490	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	156	210	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	62	111	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	25	62	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	451	490	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	156	210	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	62	111	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	25	62	25	467	Chain	ID=PRO_0000292263;Note=M-alpha
PMEL	P40967	451	490	470	661	Chain	ID=PRO_0000386648;Note=M-beta
PMEL	P40967	451	490	470	661	Chain	ID=PRO_0000386648;Note=M-beta
PMEL	P40967	451	490	470	661	Chain	ID=PRO_0000386648;Note=M-beta
PMEL	P40967	451	490	470	595	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	451	490	470	595	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	451	490	470	595	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	81	81	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	81	81	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	81	81	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	106	106	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	106	106	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	106	106	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PMEL	P40967	62	111	26	111	Alternative sequence	ID=VSP_038266;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMEL	P40967	25	62	26	111	Alternative sequence	ID=VSP_038266;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMEL	P40967	62	111	26	111	Alternative sequence	ID=VSP_038266;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMEL	P40967	25	62	26	111	Alternative sequence	ID=VSP_038266;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMEL	P40967	62	111	26	111	Alternative sequence	ID=VSP_038266;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMEL	P40967	25	62	26	111	Alternative sequence	ID=VSP_038266;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PMEL	P40967	451	490	468	469	Mutagenesis	Note=Loss of proteolytic cleavage. KR->QQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12732614;Dbxref=PMID:12732614
PMEL	P40967	451	490	468	469	Mutagenesis	Note=Loss of proteolytic cleavage. KR->QQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12732614;Dbxref=PMID:12732614
PMEL	P40967	451	490	468	469	Mutagenesis	Note=Loss of proteolytic cleavage. KR->QQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12732614;Dbxref=PMID:12732614
PMEL	P40967	156	210	162	162	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PMEL	P40967	156	210	162	162	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PMEL	P40967	156	210	162	162	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
POMGNT1	Q8WZA1	370	384	1	660	Chain	ID=PRO_0000191390;Note=Protein O-linked-mannose beta-1%2C2-N-acetylglucosaminyltransferase 1
POMGNT1	Q8WZA1	217	250	1	660	Chain	ID=PRO_0000191390;Note=Protein O-linked-mannose beta-1%2C2-N-acetylglucosaminyltransferase 1
POMGNT1	Q8WZA1	140	178	1	660	Chain	ID=PRO_0000191390;Note=Protein O-linked-mannose beta-1%2C2-N-acetylglucosaminyltransferase 1
POMGNT1	Q8WZA1	370	384	59	660	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11709191;Dbxref=PMID:11709191
POMGNT1	Q8WZA1	217	250	59	660	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11709191;Dbxref=PMID:11709191
POMGNT1	Q8WZA1	140	178	59	660	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11709191;Dbxref=PMID:11709191
POMGNT1	Q8WZA1	217	250	92	288	Region	Note=Carbohydrate-binding stem domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27493216;Dbxref=PMID:27493216
POMGNT1	Q8WZA1	140	178	92	288	Region	Note=Carbohydrate-binding stem domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27493216;Dbxref=PMID:27493216
POMGNT1	Q8WZA1	370	384	300	646	Region	Note=Catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15207699,ECO:0000269|PubMed:27493216;Dbxref=PMID:15207699,PMID:27493216
POMGNT1	Q8WZA1	370	384	371	371	Binding site	Note=UDP-GlcNAc;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:5GGI,ECO:0000305|PubMed:27493216;Dbxref=PMID:27493216
POMGNT1	Q8WZA1	140	178	156	156	Natural variant	ID=VAR_076524;Note=In RP76%3B reduced acetylglucosaminyltransferase activity. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26908613;Dbxref=dbSNP:rs886037947,PMID:26908613
POMGNT1	Q8WZA1	140	178	176	176	Natural variant	ID=VAR_065021;Note=In MDDGA3. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19067344;Dbxref=dbSNP:rs386834030,PMID:19067344
POMGNT1	Q8WZA1	217	250	223	223	Natural variant	ID=VAR_023101;Note=In MDDGA3%3B specific activity abolished in the membrane bound form but not the soluble form. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588800,ECO:0000269|PubMed:12788071,ECO:0000269|PubMed:15207699;Dbxref=dbSNP:rs386834036,PMID:12588800,PMID:12788071,PMID:15207699
POMGNT1	Q8WZA1	217	250	250	250	Natural variant	ID=VAR_030645;Note=E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855359,PMID:15489334
POMGNT1	Q8WZA1	140	178	138	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGN
POMGNT1	Q8WZA1	140	178	143	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGN
POMGNT1	Q8WZA1	140	178	156	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGN
POMGNT1	Q8WZA1	140	178	171	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGN
POMGNT1	Q8WZA1	217	250	220	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGN
POMGNT1	Q8WZA1	217	250	229	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGG
POMGNT1	Q8WZA1	217	250	238	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGN
POMGNT1	Q8WZA1	217	250	249	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGF
POMGNT1	Q8WZA1	370	384	364	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GGF
NPHS2	Q9NP85	178	246	1	383	Chain	ID=PRO_0000094035;Note=Podocin
NPHS2	Q9NP85	178	246	124	383	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPHS2	Q9NP85	178	246	179	246	Alternative sequence	ID=VSP_000499;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NPHS2	Q9NP85	178	246	138	383	Natural variant	ID=VAR_079808;Note=In NPHS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20798252;Dbxref=PMID:20798252
NPHS2	Q9NP85	178	246	180	180	Natural variant	ID=VAR_010235;Note=In NPHS2. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10742096,ECO:0000269|PubMed:24072147;Dbxref=dbSNP:rs74315347,PMID:10742096,PMID:24072147
NPHS2	Q9NP85	178	246	183	183	Natural variant	ID=VAR_071226;Note=In NPHS2. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24227627;Dbxref=PMID:24227627
NPHS2	Q9NP85	178	246	187	187	Natural variant	ID=VAR_071227;Note=In NPHS2%3B unknown pathological significance. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20947785;Dbxref=PMID:20947785
NPHS2	Q9NP85	178	246	192	192	Natural variant	ID=VAR_072148;Note=In NPHS2. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17899208;Dbxref=PMID:17899208
NPHS2	Q9NP85	178	246	208	208	Natural variant	ID=VAR_071228;Note=In NPHS2. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15253708;Dbxref=dbSNP:rs200587413,PMID:15253708
NPHS2	Q9NP85	178	246	211	211	Natural variant	ID=VAR_072149;Note=In NPHS2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17899208;Dbxref=PMID:17899208
NPHS2	Q9NP85	178	246	213	213	Natural variant	ID=VAR_072150;Note=In NPHS2. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17899208;Dbxref=PMID:17899208
NPHS2	Q9NP85	178	246	218	218	Natural variant	ID=VAR_072151;Note=In NPHS2. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17899208;Dbxref=PMID:17899208
NPHS2	Q9NP85	178	246	221	221	Natural variant	ID=VAR_071229;Note=In NPHS2. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20947785;Dbxref=PMID:20947785
NPHS2	Q9NP85	178	246	228	228	Natural variant	ID=VAR_072152;Note=In NPHS2. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17899208;Dbxref=PMID:17899208
NPHS2	Q9NP85	178	246	229	229	Natural variant	ID=VAR_072153;Note=In NPHS2. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17899208;Dbxref=PMID:17899208
NPHS2	Q9NP85	178	246	229	229	Natural variant	ID=VAR_071230;Note=In NPHS2%3B associated with susceptibility to NPHS2%3B pathogenic only when combined with other mutations on the other allele. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12464671,ECO:0000269|PubMed:20798252,ECO:0000269|PubMed:21722858,ECO:0000269|PubMed:23800802,ECO:0000269|PubMed:24509478,ECO:0000269|PubMed:26420286;Dbxref=dbSNP:rs61747728,PMID:12464671,PMID:20798252,PMID:21722858,PMID:23800802,PMID:24509478,PMID:26420286
NPHS2	Q9NP85	178	246	236	238	Natural variant	ID=VAR_071231;Note=In NPHS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15253708;Dbxref=PMID:15253708
NPHS2	Q9NP85	178	246	237	237	Natural variant	ID=VAR_071232;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15253708,ECO:0000269|PubMed:24227627;Dbxref=dbSNP:rs146906190,PMID:15253708,PMID:24227627
NPHS2	Q9NP85	178	246	238	238	Natural variant	ID=VAR_071233;Note=In NPHS2. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15253708,ECO:0000269|PubMed:24072147;Dbxref=dbSNP:rs748812981,PMID:15253708,PMID:24072147
NPHS2	Q9NP85	178	246	242	242	Natural variant	ID=VAR_071234;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15253708;Dbxref=dbSNP:rs61747727,PMID:15253708
PIP5K1C	O60331	640	668	1	668	Chain	ID=PRO_0000185462;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PIP5K1C	O60331	550	560	1	668	Chain	ID=PRO_0000185462;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PIP5K1C	O60331	448	503	1	668	Chain	ID=PRO_0000185462;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PIP5K1C	O60331	376	403	1	668	Chain	ID=PRO_0000185462;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PIP5K1C	O60331	156	207	1	668	Chain	ID=PRO_0000185462;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PIP5K1C	O60331	42	73	1	668	Chain	ID=PRO_0000185462;Note=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PIP5K1C	O60331	376	403	75	443	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP5K1C	O60331	156	207	75	443	Domain	Note=PIPK;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00781
PIP5K1C	O60331	640	668	641	668	Region	Note=Mediates interaction with TLN2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12422219;Dbxref=PMID:12422219
PIP5K1C	O60331	448	503	459	459	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70161
PIP5K1C	O60331	448	503	459	459	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70161
PIP5K1C	O60331	550	560	555	555	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5I6B8
PIP5K1C	O60331	640	668	649	649	Modified residue	Note=Phosphotyrosine%3B by CSK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15738269;Dbxref=PMID:15738269
PIP5K1C	O60331	640	668	650	650	Modified residue	Note=Phosphoserine%3B by CDK5%2C MAPK1 and CDK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15738269;Dbxref=PMID:15738269
PIP5K1C	O60331	640	668	662	662	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O70161
PIP5K1C	O60331	640	668	666	666	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5I6B8
PIP5K1C	O60331	640	668	668	668	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5I6B8
PIP5K1C	O60331	640	668	640	668	Alternative sequence	ID=VSP_042078;Note=In isoform 2. FPTDERSWVYSPLHYSAQAPPASDGESDT->FWRLWGPHAPTWPWRREGRAACLCPYPPHVVTPFPGTGLCASWSPDGTGGLGAMSCCVSVS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19548880;Dbxref=PMID:19548880
PIP5K1C	O60331	640	668	641	668	Alternative sequence	ID=VSP_042080;Note=In isoform 3. PTDERSWVYSPLHYSAQAPPASDGESDT->FTDGRYWIYSPRHRRLRAVTLSASGTVSDRSRPPWGEGAVPLGQQGAAGPRPEAQCLTSVVFQKGFG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19548880;Dbxref=PMID:19548880
PIP5K1C	O60331	640	668	641	668	Alternative sequence	ID=VSP_042079;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIP5K1C	O60331	640	668	650	650	Mutagenesis	Note=Abolishes binding to TLN2. Affects localization to focal adhesions. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15738269;Dbxref=PMID:15738269
PIP5K1C	O60331	640	668	650	650	Mutagenesis	Note=Does not affect binding to TLN2 and localization to focal adhesions. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15738269;Dbxref=PMID:15738269
PIP5K1C	O60331	640	668	644	646	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H1Z
PIGV	Q9NUD9	26	400	1	493	Chain	ID=PRO_0000246234;Note=GPI mannosyltransferase 2
PIGV	Q9NUD9	26	400	1	493	Chain	ID=PRO_0000246234;Note=GPI mannosyltransferase 2
PIGV	Q9NUD9	26	400	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	35	77	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	35	77	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	78	98	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	78	98	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	99	113	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	99	113	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	114	134	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	114	134	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	135	136	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	135	136	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	158	161	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	158	161	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	183	192	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	183	192	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	193	213	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	193	213	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	214	234	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	214	234	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	235	255	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	235	255	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	256	327	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	256	327	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	328	348	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	328	348	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	349	378	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	349	378	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	379	399	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	379	399	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	400	469	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	400	469	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGV	Q9NUD9	26	400	256	256	Natural variant	ID=VAR_064190;Note=In HPMRS1. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs267606952,PMID:20802478
PIGV	Q9NUD9	26	400	256	256	Natural variant	ID=VAR_064190;Note=In HPMRS1. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs267606952,PMID:20802478
PIGV	Q9NUD9	26	400	341	341	Natural variant	ID=VAR_064191;Note=In HPMRS1. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs139073416,PMID:20802478
PIGV	Q9NUD9	26	400	341	341	Natural variant	ID=VAR_064191;Note=In HPMRS1. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs139073416,PMID:20802478
PIGV	Q9NUD9	26	400	341	341	Natural variant	ID=VAR_064192;Note=In HPMRS1. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs139073416,PMID:20802478
PIGV	Q9NUD9	26	400	341	341	Natural variant	ID=VAR_064192;Note=In HPMRS1. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs139073416,PMID:20802478
PIGV	Q9NUD9	26	400	385	385	Natural variant	ID=VAR_064193;Note=In HPMRS1. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs267606951,PMID:20802478
PIGV	Q9NUD9	26	400	385	385	Natural variant	ID=VAR_064193;Note=In HPMRS1. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20802478;Dbxref=dbSNP:rs267606951,PMID:20802478
PIGV	Q9NUD9	26	400	66	66	Mutagenesis	Note=Loss of function. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	66	66	Mutagenesis	Note=Loss of function. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	67	67	Mutagenesis	Note=Loss of function. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	67	67	Mutagenesis	Note=Loss of function. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	293	294	Mutagenesis	Note=N-glycosylated due to the creation of an acceptor site for N-glycosylation. PP->TA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	293	294	Mutagenesis	Note=N-glycosylated due to the creation of an acceptor site for N-glycosylation. PP->TA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	308	308	Mutagenesis	Note=Induces a reduces enzyme activity. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	308	308	Mutagenesis	Note=Induces a reduces enzyme activity. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	312	312	Mutagenesis	Note=Loss of function. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	312	312	Mutagenesis	Note=Loss of function. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15623507;Dbxref=PMID:15623507
PIGV	Q9NUD9	26	400	33	33	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGV	Q9NUD9	26	400	33	33	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIF1	Q9H611	230	272	1	641	Chain	ID=PRO_0000089980;Note=ATP-dependent DNA helicase PIF1
PIF1	Q9H611	230	272	1	641	Chain	ID=PRO_0000089980;Note=ATP-dependent DNA helicase PIF1
PIF1	Q9H611	230	272	228	235	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03176
PIF1	Q9H611	230	272	228	235	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03176
PIF1	Q9H611	230	272	167	641	Region	Note=Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA%3B weak activity in the presence of RNA or double-stranded DNA%3B No unwinding activity
PIF1	Q9H611	230	272	167	641	Region	Note=Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA%3B weak activity in the presence of RNA or double-stranded DNA%3B No unwinding activity
PIF1	Q9H611	230	272	232	266	Alternative sequence	ID=VSP_026715;Note=In isoform 2. TGKSYLLKRILGSLPPTGTVATASTGVAACHIGGT->SGGREEVGGQWWGGIEEQGDLSNFAPVQEQGSHIC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIF1	Q9H611	230	272	232	266	Alternative sequence	ID=VSP_026715;Note=In isoform 2. TGKSYLLKRILGSLPPTGTVATASTGVAACHIGGT->SGGREEVGGQWWGGIEEQGDLSNFAPVQEQGSHIC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIF1	Q9H611	230	272	267	641	Alternative sequence	ID=VSP_026716;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIF1	Q9H611	230	272	267	641	Alternative sequence	ID=VSP_026716;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIF1	Q9H611	230	272	234	234	Mutagenesis	Note=Loss of ATPase activity. Lower activity for single-stranded DNA. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16522649;Dbxref=PMID:16522649
PIF1	Q9H611	230	272	234	234	Mutagenesis	Note=Loss of ATPase activity. Lower activity for single-stranded DNA. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16522649;Dbxref=PMID:16522649
PILRA	Q9UKJ1	151	224	20	303	Chain	ID=PRO_0000226821;Note=Paired immunoglobulin-like type 2 receptor alpha
PILRA	Q9UKJ1	151	224	20	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PILRA	Q9UKJ1	151	224	198	218	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PILRA	Q9UKJ1	151	224	219	303	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PILRA	Q9UKJ1	151	224	152	303	Alternative sequence	ID=VSP_017500;Note=In isoform 4. AVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA->GNPSKTQRSHMRISGMKDKIQIPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10903717;Dbxref=PMID:10903717
PILRA	Q9UKJ1	151	224	152	224	Alternative sequence	ID=VSP_017501;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10903717;Dbxref=PMID:10903717
PIM1	P11309	63	80	1	313	Chain	ID=PRO_0000043349;Note=Serine/threonine-protein kinase pim-1
PIM1	P11309	202	261	1	313	Chain	ID=PRO_0000043349;Note=Serine/threonine-protein kinase pim-1
PIM1	P11309	63	80	38	290	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PIM1	P11309	202	261	38	290	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PIM1	P11309	63	80	67	67	Binding site	Note=ATP
PIM1	P11309	202	261	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15657054;Dbxref=PMID:15657054
PIM1	P11309	63	80	68	68	Mutagenesis	Note=Increased kinase activity. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15808862;Dbxref=PMID:15808862
PIM1	P11309	63	80	63	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	63	80	71	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	63	80	77	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	202	261	205	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	202	261	210	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	202	261	220	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	202	261	245	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
PIM1	P11309	202	261	261	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99
RBL2	Q08999	124	190	1	1139	Chain	ID=PRO_0000167841;Note=Retinoblastoma-like protein 2
RBL2	Q08999	212	255	1	1139	Chain	ID=PRO_0000167841;Note=Retinoblastoma-like protein 2
RBL2	Q08999	520	566	1	1139	Chain	ID=PRO_0000167841;Note=Retinoblastoma-like protein 2
RBL2	Q08999	658	748	1	1139	Chain	ID=PRO_0000167841;Note=Retinoblastoma-like protein 2
RBL2	Q08999	901	925	1	1139	Chain	ID=PRO_0000167841;Note=Retinoblastoma-like protein 2
RBL2	Q08999	1028	1083	1	1139	Chain	ID=PRO_0000167841;Note=Retinoblastoma-like protein 2
RBL2	Q08999	520	566	417	1024	Region	Note=Pocket%3B binds E1A
RBL2	Q08999	658	748	417	1024	Region	Note=Pocket%3B binds E1A
RBL2	Q08999	901	925	417	1024	Region	Note=Pocket%3B binds E1A
RBL2	Q08999	520	566	417	616	Region	Note=Domain A
RBL2	Q08999	658	748	617	827	Region	Note=Spacer
RBL2	Q08999	901	925	828	1024	Region	Note=Domain B
RBL2	Q08999	658	748	662	662	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
RBL2	Q08999	658	748	672	672	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:12435635;Dbxref=PMID:19690332,PMID:12435635
RBL2	Q08999	658	748	688	688	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBL2	Q08999	1028	1083	1035	1035	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RBL2	Q08999	1028	1083	1068	1068	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBL2	Q08999	1028	1083	1080	1080	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBL2	Q08999	124	190	1	216	Alternative sequence	ID=VSP_054328;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBL2	Q08999	212	255	1	216	Alternative sequence	ID=VSP_054328;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBL2	Q08999	658	748	638	1042	Alternative sequence	ID=VSP_054329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBL2	Q08999	901	925	638	1042	Alternative sequence	ID=VSP_054329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBL2	Q08999	1028	1083	638	1042	Alternative sequence	ID=VSP_054329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PITPNC1	Q9UKF7	154	206	1	332	Chain	ID=PRO_0000287530;Note=Cytoplasmic phosphatidylinositol transfer protein 1
PITPNC1	Q9UKF7	154	206	191	191	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PITPNM2	Q9BZ72	856	910	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	744	801	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	554	594	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	317	349	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	856	910	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	744	801	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	554	594	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	317	349	1	1349	Chain	ID=PRO_0000232741;Note=Membrane-associated phosphatidylinositol transfer protein 2
PITPNM2	Q9BZ72	856	910	715	963	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
PITPNM2	Q9BZ72	744	801	715	963	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
PITPNM2	Q9BZ72	856	910	715	963	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
PITPNM2	Q9BZ72	744	801	715	963	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
PITPNM2	Q9BZ72	317	349	337	337	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPQ6
PITPNM2	Q9BZ72	317	349	337	337	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPQ6
PITPNM2	Q9BZ72	317	349	341	341	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPQ6
PITPNM2	Q9BZ72	317	349	341	341	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPQ6
PITPNM2	Q9BZ72	554	594	589	589	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPQ6
PITPNM2	Q9BZ72	554	594	589	589	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPQ6
PITPNM2	Q9BZ72	317	349	50	328	Alternative sequence	ID=VSP_017961;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PITPNM2	Q9BZ72	317	349	50	328	Alternative sequence	ID=VSP_017961;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PITPNM2	Q9BZ72	856	910	857	911	Alternative sequence	ID=VSP_017963;Note=In isoform 2. KAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEV->I;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
PITPNM2	Q9BZ72	856	910	857	911	Alternative sequence	ID=VSP_017963;Note=In isoform 2. KAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEV->I;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
PIK3CD	O00329	604	651	1	1044	Chain	ID=PRO_0000088790;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit delta isoform
PIK3CD	O00329	604	651	497	674	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3CD	O00329	604	651	302	1044	Alternative sequence	ID=VSP_044410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22020336;Dbxref=PMID:22020336
PIK3CD	O00329	604	651	605	610	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXU
PIK3CD	O00329	604	651	612	618	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXU
PIK3CD	O00329	604	651	619	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXU
PIK3CD	O00329	604	651	623	626	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXU
PIK3CD	O00329	604	651	628	639	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXU
PIK3CD	O00329	604	651	641	652	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXU
PKP2	Q99959	459	503	1	881	Chain	ID=PRO_0000064286;Note=Plakophilin-2
PKP2	Q99959	459	503	427	467	Repeat	Note=ARM 3
PKP2	Q99959	459	503	460	503	Alternative sequence	ID=VSP_006736;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8922383;Dbxref=PMID:15489334,PMID:8922383
PKP2	Q99959	459	503	79	881	Natural variant	ID=VAR_080398;Note=In ARVD9. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19955750;Dbxref=PMID:19955750
PKP2	Q99959	459	503	489	489	Natural variant	ID=VAR_065712;Note=In ARVD9%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19955750;Dbxref=dbSNP:rs111450489,PMID:19955750
PKP2	Q99959	459	503	490	490	Natural variant	ID=VAR_070037;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21378009;Dbxref=dbSNP:rs149930872,PMID:21378009
PKP2	Q99959	459	503	452	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TT9
PLCZ1	Q86YW0	238	288	1	608	Chain	ID=PRO_0000347244;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase zeta-1
PLCZ1	Q86YW0	238	288	155	299	Domain	Note=PI-PLC X-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270
PLCZ1	Q86YW0	238	288	46	238	Alternative sequence	ID=VSP_052862;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLK5	Q496M5	238	275	1	336	Chain	ID=PRO_0000280397;Note=Inactive serine/threonine-protein kinase PLK5
PLK5	Q496M5	238	275	1	336	Chain	ID=PRO_0000280397;Note=Inactive serine/threonine-protein kinase PLK5
PLK5	Q496M5	238	275	259	334	Domain	Note=POLO box
PLK5	Q496M5	238	275	259	334	Domain	Note=POLO box
PLK5	Q496M5	238	275	265	268	Compositional bias	Note=Poly-Leu
PLK5	Q496M5	238	275	265	268	Compositional bias	Note=Poly-Leu
PLK5	Q496M5	238	275	239	275	Alternative sequence	ID=VSP_023654;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PLK5	Q496M5	238	275	239	275	Alternative sequence	ID=VSP_023654;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
FXYD1	O00168	20	31	1	20	Signal peptide	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56513
FXYD1	O00168	20	31	1	20	Signal peptide	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56513
FXYD1	O00168	20	31	1	20	Signal peptide	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56513
FXYD1	O00168	20	31	1	20	Signal peptide	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56513
FXYD1	O00168	20	31	1	20	Signal peptide	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56513
FXYD1	O00168	20	31	1	20	Signal peptide	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56513
FXYD1	O00168	20	31	21	92	Chain	ID=PRO_0000010359;Note=Phospholemman
FXYD1	O00168	20	31	21	92	Chain	ID=PRO_0000010359;Note=Phospholemman
FXYD1	O00168	20	31	21	92	Chain	ID=PRO_0000010359;Note=Phospholemman
FXYD1	O00168	20	31	21	92	Chain	ID=PRO_0000010359;Note=Phospholemman
FXYD1	O00168	20	31	21	92	Chain	ID=PRO_0000010359;Note=Phospholemman
FXYD1	O00168	20	31	21	92	Chain	ID=PRO_0000010359;Note=Phospholemman
FXYD1	O00168	20	31	21	35	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD1	O00168	20	31	21	35	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD1	O00168	20	31	21	35	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD1	O00168	20	31	21	35	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD1	O00168	20	31	21	35	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD1	O00168	20	31	21	35	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD1	O00168	20	31	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	28	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	28	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	28	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	28	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	28	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
FXYD1	O00168	20	31	28	30	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JO1
PLOD2	O00469	538	560	26	737	Chain	ID=PRO_0000024683;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 2
PLOD2	O00469	500	538	26	737	Chain	ID=PRO_0000024683;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 2
PLOD2	O00469	376	410	26	737	Chain	ID=PRO_0000024683;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 2
PLOD2	O00469	293	335	26	737	Chain	ID=PRO_0000024683;Note=Procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 2
PLOD2	O00469	293	335	320	320	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18088087;Dbxref=PMID:18088087
PLOD2	O00469	293	335	323	323	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18088087;Dbxref=PMID:18088087
PLOD2	O00469	293	335	297	297	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLOD2	O00469	500	538	522	522	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
PLOD2	O00469	376	410	37	376	Alternative sequence	ID=VSP_057222;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLOD2	O00469	293	335	37	376	Alternative sequence	ID=VSP_057222;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLOD2	O00469	500	538	500	500	Alternative sequence	ID=VSP_013467;Note=In isoform 2 and isoform 3. M->MTLQREKDSPTPETFQMLSPPK;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10372558,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10372558,PMID:14702039,PMID:15489334
RBM18	Q96H35	80	109	1	190	Chain	ID=PRO_0000254122;Note=Probable RNA-binding protein 18
RBM18	Q96H35	80	109	25	106	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM19	Q9Y4C8	333	357	1	960	Chain	ID=PRO_0000081781;Note=Probable RNA-binding protein 19
RBM19	Q9Y4C8	333	357	1	960	Chain	ID=PRO_0000081781;Note=Probable RNA-binding protein 19
RBM19	Q9Y4C8	333	357	1	960	Chain	ID=PRO_0000081781;Note=Probable RNA-binding protein 19
RBM19	Q9Y4C8	333	357	294	369	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM19	Q9Y4C8	333	357	294	369	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM19	Q9Y4C8	333	357	294	369	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM19	Q9Y4C8	333	357	332	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	332	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	332	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	343	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	343	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	343	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	354	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	354	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBM19	Q9Y4C8	333	357	354	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGW
RBMY1E	A6NEQ0	381	418	1	496	Chain	ID=PRO_0000341539;Note=RNA-binding motif protein%2C Y chromosome%2C family 1 member E
RBMY1E	A6NEQ0	381	418	1	496	Chain	ID=PRO_0000341539;Note=RNA-binding motif protein%2C Y chromosome%2C family 1 member E
PLXNC1	O60486	401	446	35	1568	Chain	ID=PRO_0000232749;Note=Plexin-C1
PLXNC1	O60486	1029	1042	35	1568	Chain	ID=PRO_0000232749;Note=Plexin-C1
PLXNC1	O60486	401	446	35	944	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNC1	O60486	1029	1042	966	1568	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNC1	O60486	401	446	35	452	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXNC1	O60486	401	446	407	407	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20727575;Dbxref=PMID:20727575
PLXNC1	O60486	401	446	397	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NVN
PLXNC1	O60486	401	446	414	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NVN
PLXNC1	O60486	401	446	438	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NVN
PLXNC1	O60486	401	446	446	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NVN
PLXND1	Q9Y4D7	1362	1397	47	1925	Chain	ID=PRO_0000024676;Note=Plexin-D1
PLXND1	Q9Y4D7	782	812	47	1925	Chain	ID=PRO_0000024676;Note=Plexin-D1
PLXND1	Q9Y4D7	496	540	47	1925	Chain	ID=PRO_0000024676;Note=Plexin-D1
PLXND1	Q9Y4D7	782	812	47	1271	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXND1	Q9Y4D7	496	540	47	1271	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXND1	Q9Y4D7	1362	1397	1293	1925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXND1	Q9Y4D7	496	540	47	546	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
PLXND1	Q9Y4D7	496	540	500	500	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
PLXND1	Q9Y4D7	782	812	802	802	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXND1	Q9Y4D7	496	540	531	531	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLXND1	Q9Y4D7	496	540	531	531	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
NOP56	O00567	427	473	1	594	Chain	ID=PRO_0000219025;Note=Nucleolar protein 56
NOP56	O00567	427	473	438	589	Compositional bias	Note=Lys-rich
NOP56	O00567	427	473	466	466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D6Z1
NOP56	O00567	427	473	467	467	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D6Z1
NOP56	O00567	427	473	468	468	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D6Z1
NOP56	O00567	427	473	427	427	Sequence conflict	Note=Q->QAE;Ontology_term=ECO:0000305;evidence=ECO:0000305
NPDC1	Q9NQX5	128	185	35	325	Chain	ID=PRO_0000021830;Note=Neural proliferation differentiation and control protein 1
NPDC1	Q9NQX5	128	185	182	202	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPDC1	Q9NQX5	128	185	145	167	Compositional bias	Note=Pro/Ser/Thr-rich
NPDC1	Q9NQX5	128	185	159	159	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC34A1	Q06495	36	86	1	639	Chain	ID=PRO_0000068607;Note=Sodium-dependent phosphate transport protein 2A
SLC34A1	Q06495	335	391	1	639	Chain	ID=PRO_0000068607;Note=Sodium-dependent phosphate transport protein 2A
SLC34A1	Q06495	36	86	1	103	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A1	Q06495	335	391	186	347	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A1	Q06495	335	391	348	370	Transmembrane	Note=Helical%3B Name%3DM4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A1	Q06495	335	391	371	412	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A1	Q06495	335	391	225	522	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC34A1	Q06495	335	391	306	336	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC34A1	Q06495	335	391	313	639	Alternative sequence	ID=VSP_042311;Note=In isoform 2. APTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL->QNLEGREITHFDLRKKQAMEDSSVPHCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC34A1	Q06495	36	86	48	48	Natural variant	ID=VAR_024765;Note=In NPHLOP1%3B causes hypophosphatemic urolithiasis%3B requires 2 nucleotide substitutions%3B results in lower phosphate current%2C decreases affinity for phosphate and decreases phosphate uptake compared to wild-type%3B shows a dominant-negative effect. A->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12324554;Dbxref=dbSNP:rs121918610,PMID:12324554
SLC34A1	Q06495	335	391	336	336	Natural variant	ID=VAR_077918;Note=In HCINF2%3B loss of phosphate transport activity%3B loss of localization to apical plasma membrane%3B display a complete intracellular retention and no detectable actin colocalization. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26047794;Dbxref=dbSNP:rs876661338,PMID:26047794
SLC34A2	O95436	349	405	1	690	Chain	ID=PRO_0000068613;Note=Sodium-dependent phosphate transport protein 2B
SLC34A2	O95436	349	405	234	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A2	O95436	349	405	363	383	Transmembrane	Note=Helical%3B Name%3DM4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A2	O95436	349	405	384	407	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A2	O95436	349	405	303	350	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC34A3	Q8N130	252	282	1	599	Chain	ID=PRO_0000068617;Note=Sodium-dependent phosphate transport protein 2C
SLC34A3	Q8N130	252	282	1	599	Chain	ID=PRO_0000068617;Note=Sodium-dependent phosphate transport protein 2C
SLC34A3	Q8N130	252	282	210	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A3	Q8N130	252	282	210	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A3	Q8N130	252	282	265	265	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A3	Q8N130	252	282	265	265	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A3	Q8N130	252	282	268	268	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A3	Q8N130	252	282	268	268	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC34A3	Q8N130	252	282	276	309	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC34A3	Q8N130	252	282	276	309	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NRK	Q7Z2Y5	60	84	1	1582	Chain	ID=PRO_0000250511;Note=Nik-related protein kinase
NRK	Q7Z2Y5	1218	1266	1	1582	Chain	ID=PRO_0000250511;Note=Nik-related protein kinase
NRK	Q7Z2Y5	1353	1401	1	1582	Chain	ID=PRO_0000250511;Note=Nik-related protein kinase
NRK	Q7Z2Y5	60	84	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NRK	Q7Z2Y5	1218	1266	1209	1552	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
NRK	Q7Z2Y5	1353	1401	1209	1552	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
NRK	Q7Z2Y5	60	84	1	332	Alternative sequence	ID=VSP_020654;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NRK	Q7Z2Y5	1218	1266	189	1582	Alternative sequence	ID=VSP_020656;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NRK	Q7Z2Y5	1353	1401	189	1582	Alternative sequence	ID=VSP_020656;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NTHL1	P78549	126	183	31	312	Chain	ID=PRO_0000102227;Note=Endonuclease III-like protein 1
NTHL1	P78549	126	183	176	176	Natural variant	ID=VAR_016127;Note=I->T;Dbxref=dbSNP:rs1805378
NTHL1	P78549	126	183	151	151	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
NTHL1	P78549	126	183	160	160	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP155	O75694	1149	1187	2	1391	Chain	ID=PRO_0000204844;Note=Nuclear pore complex protein Nup155
NUP155	O75694	812	876	2	1391	Chain	ID=PRO_0000204844;Note=Nuclear pore complex protein Nup155
NUP155	O75694	506	543	2	1391	Chain	ID=PRO_0000204844;Note=Nuclear pore complex protein Nup155
NUP155	O75694	449	506	2	1391	Chain	ID=PRO_0000204844;Note=Nuclear pore complex protein Nup155
NUP155	O75694	364	415	2	1391	Chain	ID=PRO_0000204844;Note=Nuclear pore complex protein Nup155
NUP155	O75694	154	185	2	1391	Chain	ID=PRO_0000204844;Note=Nuclear pore complex protein Nup155
NUP155	O75694	506	543	526	526	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUP155	O75694	364	415	391	391	Natural variant	ID=VAR_071762;Note=In ATFB15%3B fails to accumulate at various foci of the nuclear envelope and is diffusely distributed in the cytoplasm%3B shows significantly reduced permeability of the nuclear envelope compared to wild-type. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19070573;Dbxref=dbSNP:rs587777339,PMID:19070573
NKG7	Q16617	101	146	1	165	Chain	ID=PRO_0000164667;Note=Protein NKG7
NKG7	Q16617	52	101	1	165	Chain	ID=PRO_0000164667;Note=Protein NKG7
NKG7	Q16617	52	101	61	81	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKG7	Q16617	101	146	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKG7	Q16617	52	101	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKG7	Q16617	101	146	133	153	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOP14	P78316	249	290	1	857	Chain	ID=PRO_0000137155;Note=Nucleolar protein 14
NOP14	P78316	249	290	1	857	Chain	ID=PRO_0000137155;Note=Nucleolar protein 14
URB1	O60287	1865	1930	1	2271	Chain	ID=PRO_0000057939;Note=Nucleolar pre-ribosomal-associated protein 1
URB1	O60287	1780	1828	1	2271	Chain	ID=PRO_0000057939;Note=Nucleolar pre-ribosomal-associated protein 1
URB1	O60287	748	805	1	2271	Chain	ID=PRO_0000057939;Note=Nucleolar pre-ribosomal-associated protein 1
URB1	O60287	623	663	1	2271	Chain	ID=PRO_0000057939;Note=Nucleolar pre-ribosomal-associated protein 1
URB1	O60287	399	445	1	2271	Chain	ID=PRO_0000057939;Note=Nucleolar pre-ribosomal-associated protein 1
URB1	O60287	1780	1828	1791	1791	Natural variant	ID=VAR_060586;Note=V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10773462,ECO:0000269|PubMed:9628581;Dbxref=dbSNP:rs3761342,PMID:10773462,PMID:9628581
NIPAL2	Q9H841	125	145	1	368	Chain	ID=PRO_0000242148;Note=NIPA-like protein 2
NIPAL2	Q9H841	125	145	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPAL2	Q9H841	125	145	144	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMPD2	O60906	106	136	1	423	Chain	ID=PRO_0000075686;Note=Sphingomyelin phosphodiesterase 2
NUP35	Q8NFH5	246	301	1	326	Chain	ID=PRO_0000234294;Note=Nucleoporin NUP35
NUP35	Q8NFH5	246	301	170	250	Domain	Note=RRM Nup35-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00804
NUP35	Q8NFH5	246	301	252	252	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R4R6
NUP35	Q8NFH5	246	301	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R4R6
NUP35	Q8NFH5	246	301	265	265	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NUP35	Q8NFH5	246	301	273	273	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
NUP35	Q8NFH5	246	301	275	275	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NUP35	Q8NFH5	246	301	279	279	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
NUP35	Q8NFH5	246	301	280	280	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
NUP35	Q8NFH5	246	301	284	284	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP35	Q8NFH5	246	301	246	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIR
NUP37	Q8NFH4	241	257	1	326	Chain	ID=PRO_0000051109;Note=Nucleoporin Nup37
NUP37	Q8NFH4	241	257	1	326	Chain	ID=PRO_0000051109;Note=Nucleoporin Nup37
NUP37	Q8NFH4	241	257	242	282	Repeat	Note=WD 6
NUP37	Q8NFH4	241	257	242	282	Repeat	Note=WD 6
ORC1	Q13415	585	621	1	861	Chain	ID=PRO_0000127067;Note=Origin recognition complex subunit 1
ORC1	Q13415	585	621	1	861	Chain	ID=PRO_0000127067;Note=Origin recognition complex subunit 1
ORC1	Q13415	585	621	501	861	Region	Note=Necessary and sufficient for ORC complex assembly
ORC1	Q13415	585	621	501	861	Region	Note=Necessary and sufficient for ORC complex assembly
ORC1	Q13415	585	621	620	620	Metal binding	Note=Magnesium;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UJ7,ECO:0000244|PDB:5UJM,ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	620	620	Metal binding	Note=Magnesium;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UJ7,ECO:0000244|PDB:5UJM,ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	621	621	Metal binding	Note=Magnesium;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UJ7,ECO:0000244|PDB:5UJM,ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	621	621	Metal binding	Note=Magnesium;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UJ7,ECO:0000244|PDB:5UJM,ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	621	621	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UJ7,ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	621	621	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UJ7,ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	620	620	Mutagenesis	Note=Abolished ATPase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	620	620	Mutagenesis	Note=Abolished ATPase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28112645;Dbxref=PMID:28112645
ORC1	Q13415	585	621	578	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC1	Q13415	585	621	578	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC1	Q13415	585	621	594	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC1	Q13415	585	621	594	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC1	Q13415	585	621	616	620	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC1	Q13415	585	621	616	620	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
OSTM1	Q86WC4	205	261	32	334	Chain	ID=PRO_0000021963;Note=Osteopetrosis-associated transmembrane protein 1
OSTM1	Q86WC4	205	261	32	284	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTM1	Q86WC4	205	261	216	216	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSBPL7	Q9BZF2	67	85	1	842	Chain	ID=PRO_0000100377;Note=Oxysterol-binding protein-related protein 7
OSBPL7	Q9BZF2	67	85	1	842	Chain	ID=PRO_0000100377;Note=Oxysterol-binding protein-related protein 7
OSBPL7	Q9BZF2	67	85	47	142	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
OSBPL7	Q9BZF2	67	85	47	142	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ROR1	Q01973	30	54	30	937	Chain	ID=PRO_0000024458;Note=Inactive tyrosine-protein kinase transmembrane receptor ROR1
ROR1	Q01973	30	54	30	406	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROR1	Q01973	30	54	42	147	Domain	Note=Ig-like C2-type
ROR1	Q01973	30	54	47	47	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROR1	Q01973	30	54	1	549	Alternative sequence	ID=VSP_005008;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8875995;Dbxref=PMID:8875995
POLR2D	O15514	85	116	1	142	Chain	ID=PRO_0000073981;Note=DNA-directed RNA polymerase II subunit RPB4
POLR2D	O15514	85	116	77	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2D	O15514	85	116	94	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2D	O15514	85	116	108	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2D	O15514	85	116	116	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2G	P62487	133	157	1	172	Chain	ID=PRO_0000073986;Note=DNA-directed RNA polymerase II subunit RPB7
POLR2G	P62487	133	157	151	151	Mutagenesis	Note=Strongly reduces RNA-binding. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16282592;Dbxref=PMID:16282592
POLR2G	P62487	133	157	153	153	Mutagenesis	Note=Strongly reduces RNA-binding. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16282592;Dbxref=PMID:16282592
POLR2G	P62487	133	157	135	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2G	P62487	133	157	142	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2G	P62487	133	157	156	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
CRCP	O75575	15	48	1	148	Chain	ID=PRO_0000079335;Note=DNA-directed RNA polymerase III subunit RPC9
CRCP	O75575	15	48	4	80	Alternative sequence	ID=VSP_046273;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16344560;Dbxref=PMID:16344560
CRCP	O75575	15	48	14	46	Alternative sequence	ID=VSP_007538;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
RPN1	P04843	465	547	24	607	Chain	ID=PRO_0000022241;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
RPN1	P04843	425	465	24	607	Chain	ID=PRO_0000022241;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
RPN1	P04843	211	281	24	607	Chain	ID=PRO_0000022241;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
RPN1	P04843	425	465	24	438	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN1	P04843	211	281	24	438	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN1	P04843	425	465	439	457	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN1	P04843	465	547	458	607	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN1	P04843	425	465	458	607	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN1	P04843	465	547	538	538	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YQ5
RPN1	P04843	465	547	538	538	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
SLIRP	Q9GZT3	52	88	19	103	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SLIRP	Q9GZT3	52	88	62	62	Mutagenesis	Note=Impairs SRA-mediated repression%3B when associated with 24-A-A-25. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16762838;Dbxref=PMID:16762838
SLFN11	Q7Z7L1	356	399	1	901	Chain	ID=PRO_0000283091;Note=Schlafen family member 11
SLFN11	Q7Z7L1	356	399	1	901	Chain	ID=PRO_0000283091;Note=Schlafen family member 11
POLRMT	O00411	1108	1140	42	1230	Chain	ID=PRO_0000031068;Note=DNA-directed RNA polymerase%2C mitochondrial
POLRMT	O00411	1051	1089	42	1230	Chain	ID=PRO_0000031068;Note=DNA-directed RNA polymerase%2C mitochondrial
POLRMT	O00411	962	1022	42	1230	Chain	ID=PRO_0000031068;Note=DNA-directed RNA polymerase%2C mitochondrial
POLRMT	O00411	542	617	42	1230	Chain	ID=PRO_0000031068;Note=DNA-directed RNA polymerase%2C mitochondrial
POLRMT	O00411	1108	1140	802	1230	Region	Note=Mediates interaction with TEFM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21278163;Dbxref=PMID:21278163
POLRMT	O00411	1051	1089	802	1230	Region	Note=Mediates interaction with TEFM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21278163;Dbxref=PMID:21278163
POLRMT	O00411	962	1022	802	1230	Region	Note=Mediates interaction with TEFM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21278163;Dbxref=PMID:21278163
POLRMT	O00411	962	1022	991	991	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
POLRMT	O00411	542	617	555	555	Natural variant	ID=VAR_019427;Note=E->A;Dbxref=dbSNP:rs2238549
POLRMT	O00411	962	1022	983	983	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLRMT	O00411	542	617	549	557	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	542	617	562	564	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	542	617	569	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	542	617	588	590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BOC
POLRMT	O00411	542	617	604	610	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	542	617	613	616	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BOC
POLRMT	O00411	962	1022	955	972	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	962	1022	976	980	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	962	1022	981	983	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	962	1022	987	999	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	962	1022	1002	1004	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	962	1022	1005	1015	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	962	1022	1018	1020	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BOC
POLRMT	O00411	962	1022	1022	1024	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	1051	1089	1045	1063	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	1051	1089	1069	1071	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	1051	1089	1077	1079	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
POLRMT	O00411	1108	1140	1112	1141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SPA
SMC1B	Q8NDV3	515	577	1	1235	Chain	ID=PRO_0000118993;Note=Structural maintenance of chromosomes protein 1B
SMC1B	Q8NDV3	515	577	1	1235	Chain	ID=PRO_0000118993;Note=Structural maintenance of chromosomes protein 1B
SMC1B	Q8NDV3	515	577	514	629	Domain	Note=SMC hinge
SMC1B	Q8NDV3	515	577	514	629	Domain	Note=SMC hinge
RPP30	P78346	90	114	2	268	Chain	ID=PRO_0000140031;Note=Ribonuclease P protein subunit p30
RPP30	P78346	114	144	2	268	Chain	ID=PRO_0000140031;Note=Ribonuclease P protein subunit p30
RPP30	P78346	183	193	2	268	Chain	ID=PRO_0000140031;Note=Ribonuclease P protein subunit p30
RPP30	P78346	183	193	189	189	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC5	Q8IY18	226	273	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	327	351	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	488	526	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	799	841	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	841	856	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	888	923	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	923	963	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	963	1023	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	1023	1055	1	1101	Chain	ID=PRO_0000270951;Note=Structural maintenance of chromosomes protein 5
SMC5	Q8IY18	488	526	446	646	Region	Note=Flexible hinge
SMC5	Q8IY18	226	273	207	445	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC5	Q8IY18	327	351	207	445	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC5	Q8IY18	799	841	647	828	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC5	Q8IY18	888	923	888	927	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC5	Q8IY18	923	963	888	927	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC5	Q8IY18	963	1023	991	1026	Compositional bias	Note=Ala/Asp-rich (DA-box)
SMC5	Q8IY18	1023	1055	991	1026	Compositional bias	Note=Ala/Asp-rich (DA-box)
SMG1	Q96Q15	3247	3298	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	2398	2471	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	2232	2315	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	1820	1874	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	831	877	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	431	506	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	85	137	1	3661	Chain	ID=PRO_0000229791;Note=Serine/threonine-protein kinase SMG1
SMG1	Q96Q15	1820	1874	1131	1866	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
SMG1	Q96Q15	1820	1874	1817	1852	Repeat	Note=HEAT
SMG1	Q96Q15	2398	2471	2150	2478	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
SMG1	Q96Q15	2232	2315	2150	2478	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
SMG1	Q96Q15	1820	1874	1	1977	Region	Note=Interaction with SMG8 and SMG9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21245168;Dbxref=PMID:21245168
SMG1	Q96Q15	831	877	1	1977	Region	Note=Interaction with SMG8 and SMG9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21245168;Dbxref=PMID:21245168
SMG1	Q96Q15	431	506	1	1977	Region	Note=Interaction with SMG8 and SMG9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21245168;Dbxref=PMID:21245168
SMG1	Q96Q15	85	137	1	1977	Region	Note=Interaction with SMG8 and SMG9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21245168;Dbxref=PMID:21245168
SMG1	Q96Q15	831	877	1	1269	Alternative sequence	ID=VSP_017746;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9566925;Dbxref=PMID:9566925
SMG1	Q96Q15	431	506	1	1269	Alternative sequence	ID=VSP_017746;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9566925;Dbxref=PMID:9566925
SMG1	Q96Q15	85	137	1	1269	Alternative sequence	ID=VSP_017746;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9566925;Dbxref=PMID:9566925
SMG1	Q96Q15	431	506	1	630	Alternative sequence	ID=VSP_017747;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11331269;Dbxref=PMID:11331269
SMG1	Q96Q15	85	137	1	630	Alternative sequence	ID=VSP_017747;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11331269;Dbxref=PMID:11331269
SMG1	Q96Q15	85	137	1	140	Alternative sequence	ID=VSP_017748;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15175154;Dbxref=PMID:15175154
SMG1	Q96Q15	85	137	126	126	Natural variant	ID=VAR_041624;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs752796432,PMID:17344846
SMG1	Q96Q15	431	506	465	465	Natural variant	ID=VAR_041630;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs200419100,PMID:17344846
SMG1	Q96Q15	831	877	832	832	Natural variant	ID=VAR_041638;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs80176913,PMID:17344846
SMG1	Q96Q15	2232	2315	2258	2258	Natural variant	ID=VAR_041651;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35572280,PMID:17344846
SMG5	Q9UPR3	918	942	2	1016	Chain	ID=PRO_0000076322;Note=Protein SMG5
SMG5	Q9UPR3	761	814	2	1016	Chain	ID=PRO_0000076322;Note=Protein SMG5
SMG5	Q9UPR3	372	418	2	1016	Chain	ID=PRO_0000076322;Note=Protein SMG5
SMG5	Q9UPR3	151	181	2	1016	Chain	ID=PRO_0000076322;Note=Protein SMG5
SMG5	Q9UPR3	918	942	872	995	Domain	Note=PINc
SMG5	Q9UPR3	761	814	798	841	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMG5	Q9UPR3	372	418	372	372	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMG5	Q9UPR3	372	418	384	384	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMG5	Q9UPR3	918	942	918	922	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HWY
SMARCD2	Q92925	439	480	1	531	Chain	ID=PRO_0000071985;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
SMARCD2	Q92925	307	361	1	531	Chain	ID=PRO_0000071985;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
SMARCD2	Q92925	189	241	1	531	Chain	ID=PRO_0000071985;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
SMARCD2	Q92925	148	189	1	531	Chain	ID=PRO_0000071985;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
SMARCD2	Q92925	307	361	307	382	Domain	Note=SWIB
SMARCD2	Q92925	189	241	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SMARCD2	Q92925	189	241	217	217	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SMARCD2	Q92925	189	241	226	226	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMARCD2	Q92925	307	361	332	332	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMTNL2	Q2TAL5	162	243	1	461	Chain	ID=PRO_0000317278;Note=Smoothelin-like protein 2
SMTNL2	Q2TAL5	162	243	162	162	Natural variant	ID=VAR_038498;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12449695,PMID:14702039,PMID:15489334
SMU1	Q2TAY7	374	430	1	513	Chain	ID=PRO_0000424520;Note=WD40 repeat-containing protein SMU1
SMU1	Q2TAY7	210	250	1	513	Chain	ID=PRO_0000424520;Note=WD40 repeat-containing protein SMU1
SMU1	Q2TAY7	167	210	1	513	Chain	ID=PRO_0000424520;Note=WD40 repeat-containing protein SMU1
SMU1	Q2TAY7	130	167	1	513	Chain	ID=PRO_0000424520;Note=WD40 repeat-containing protein SMU1
SMU1	Q2TAY7	79	130	1	513	Chain	ID=PRO_0000424520;Note=WD40 repeat-containing protein SMU1
SMU1	Q2TAY7	374	430	2	513	Chain	ID=PRO_0000237590;Note=WD40 repeat-containing protein SMU1%2C N-terminally processed
SMU1	Q2TAY7	210	250	2	513	Chain	ID=PRO_0000237590;Note=WD40 repeat-containing protein SMU1%2C N-terminally processed
SMU1	Q2TAY7	167	210	2	513	Chain	ID=PRO_0000237590;Note=WD40 repeat-containing protein SMU1%2C N-terminally processed
SMU1	Q2TAY7	130	167	2	513	Chain	ID=PRO_0000237590;Note=WD40 repeat-containing protein SMU1%2C N-terminally processed
SMU1	Q2TAY7	79	130	2	513	Chain	ID=PRO_0000237590;Note=WD40 repeat-containing protein SMU1%2C N-terminally processed
SMU1	Q2TAY7	79	130	40	92	Domain	Note=CTLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00058
SMU1	Q2TAY7	210	250	212	253	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMU1	Q2TAY7	374	430	347	386	Repeat	Note=WD 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMU1	Q2TAY7	374	430	395	436	Repeat	Note=WD 5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMU1	Q2TAY7	210	250	1	315	Region	Note=Required for interaction with IK and with influenza A virus RNA polymerase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24945353;Dbxref=PMID:24945353
SMU1	Q2TAY7	167	210	1	315	Region	Note=Required for interaction with IK and with influenza A virus RNA polymerase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24945353;Dbxref=PMID:24945353
SMU1	Q2TAY7	130	167	1	315	Region	Note=Required for interaction with IK and with influenza A virus RNA polymerase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24945353;Dbxref=PMID:24945353
SMU1	Q2TAY7	79	130	1	315	Region	Note=Required for interaction with IK and with influenza A virus RNA polymerase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24945353;Dbxref=PMID:24945353
SMU1	Q2TAY7	374	430	379	379	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMU1	Q2TAY7	130	167	1	161	Alternative sequence	ID=VSP_056394;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMU1	Q2TAY7	79	130	1	161	Alternative sequence	ID=VSP_056394;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMU1	Q2TAY7	374	430	424	424	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMU1	Q2TAY7	374	430	429	429	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KL1	Q9Y6S9	450	482	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	392	422	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	190	392	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	130	146	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	481	513	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	161	177	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	130	161	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	481	513	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	161	177	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	130	161	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
RPS6KL1	Q9Y6S9	450	482	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	392	422	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	190	392	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	130	146	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	481	513	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	161	177	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	130	161	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	481	513	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	161	177	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	130	161	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	130	161	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	130	161	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	392	422	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	161	177	177	177	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	161	177	177	177	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KL1	Q9Y6S9	130	146	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPS6KL1	Q9Y6S9	161	177	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPS6KL1	Q9Y6S9	130	161	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPS6KL1	Q9Y6S9	161	177	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPS6KL1	Q9Y6S9	130	161	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPS6KL1	Q9Y6S9	190	392	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	450	482	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	392	422	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	190	392	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	481	513	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	481	513	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KL1	Q9Y6S9	190	392	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
RPS6KL1	Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
RPS6KL1	Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
SMARCAD1	Q9H4L7	648	694	1	1026	Chain	ID=PRO_0000074356;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
SMARCAD1	Q9H4L7	909	969	1	1026	Chain	ID=PRO_0000074356;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
SMARCAD1	Q9H4L7	648	694	509	677	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCAD1	Q9H4L7	909	969	858	1010	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SMARCAD1	Q9H4L7	909	969	937	937	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCD3	Q6STE5	259	313	2	483	Chain	ID=PRO_0000071988;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
SMARCD3	Q6STE5	111	152	2	483	Chain	ID=PRO_0000071988;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
SMARCD3	Q6STE5	259	313	259	334	Domain	Note=SWIB
SMARCD3	Q6STE5	111	152	140	140	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RRN3	Q9NYV6	255	286	1	651	Chain	ID=PRO_0000211426;Note=RNA polymerase I-specific transcription initiation factor RRN3
RRN3	Q9NYV6	222	255	1	651	Chain	ID=PRO_0000211426;Note=RNA polymerase I-specific transcription initiation factor RRN3
RRN3	Q9NYV6	84	114	1	651	Chain	ID=PRO_0000211426;Note=RNA polymerase I-specific transcription initiation factor RRN3
RRN3	Q9NYV6	84	114	1	149	Alternative sequence	ID=VSP_056519;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RRN3	Q9NYV6	255	286	223	255	Alternative sequence	ID=VSP_056521;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RRN3	Q9NYV6	222	255	223	255	Alternative sequence	ID=VSP_056521;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUGGC	Q68CJ6	160	237	1	796	Chain	ID=PRO_0000299479;Note=Nuclear GTPase SLIP-GC
NUGGC	Q68CJ6	160	237	158	185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUGGC	Q68CJ6	160	237	180	180	Natural variant	ID=VAR_034824;Note=S->G;Dbxref=dbSNP:rs4732620
SMYD1	Q8NB12	220	232	1	490	Chain	ID=PRO_0000218307;Note=Histone-lysine N-methyltransferase SMYD1
SMYD1	Q8NB12	220	232	7	253	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
NAPB	Q9H115	245	262	1	298	Chain	ID=PRO_0000219060;Note=Beta-soluble NSF attachment protein
NAPB	Q9H115	187	222	1	298	Chain	ID=PRO_0000219060;Note=Beta-soluble NSF attachment protein
NAPB	Q9H115	59	98	1	298	Chain	ID=PRO_0000219060;Note=Beta-soluble NSF attachment protein
NAPB	Q9H115	59	98	21	114	Alternative sequence	ID=VSP_055277;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NAPB	Q9H115	59	98	60	98	Alternative sequence	ID=VSP_055278;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NAPB	Q9H115	59	98	61	61	Natural variant	ID=VAR_052026;Note=A->T;Dbxref=dbSNP:rs6036399
SNED1	Q8TER0	71	167	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	348	386	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	386	424	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	578	617	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	752	790	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	866	904	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	1272	1305	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	1374	1401	25	1413	Chain	ID=PRO_0000299554;Note=Sushi%2C nidogen and EGF-like domain-containing protein 1
SNED1	Q8TER0	71	167	103	258	Domain	Note=NIDO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00570
SNED1	Q8TER0	348	386	349	385	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SNED1	Q8TER0	348	386	352	374	Domain	Note=Follistatin-like 1
SNED1	Q8TER0	386	424	387	423	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SNED1	Q8TER0	578	617	580	616	Domain	Note=EGF-like 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SNED1	Q8TER0	752	790	696	753	Domain	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SNED1	Q8TER0	752	790	753	789	Domain	Note=EGF-like 11%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SNED1	Q8TER0	866	904	867	903	Domain	Note=EGF-like 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SNED1	Q8TER0	71	167	145	145	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SNED1	Q8TER0	386	424	408	408	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SNED1	Q8TER0	348	386	353	364	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	348	386	358	373	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	348	386	375	384	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	386	424	391	402	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	386	424	396	411	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	386	424	413	422	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	578	617	584	595	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	578	617	589	604	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	578	617	606	615	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	752	790	757	768	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	752	790	762	777	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	752	790	779	788	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	866	904	871	882	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	866	904	876	891	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	866	904	893	902	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SNED1	Q8TER0	1272	1305	1273	1306	Alternative sequence	ID=VSP_027749;Note=In isoform 2 and isoform 3. QPTASAQLENMEEAPKRVSLALQLPEHGSKDIGN->H;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
SNED1	Q8TER0	1374	1401	1325	1413	Alternative sequence	ID=VSP_027751;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15194686;Dbxref=PMID:15194686
SNED1	Q8TER0	1374	1401	1375	1402	Alternative sequence	ID=VSP_027752;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SNED1	Q8TER0	1374	1401	1398	1398	Alternative sequence	ID=VSP_027753;Note=In isoform 3. K->L;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNED1	Q8TER0	1374	1401	1399	1413	Alternative sequence	ID=VSP_027754;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNED1	Q8TER0	1272	1305	1289	1289	Natural variant	ID=VAR_034848;Note=R->Q;Dbxref=dbSNP:rs6721345
SNED1	Q8TER0	1272	1305	1299	1299	Natural variant	ID=VAR_034849;Note=H->R;Dbxref=dbSNP:rs6708120
PDCD11	Q14690	290	326	2	1871	Chain	ID=PRO_0000205762;Note=Protein RRP5 homolog
PDCD11	Q14690	1102	1122	2	1871	Chain	ID=PRO_0000205762;Note=Protein RRP5 homolog
PDCD11	Q14690	1301	1341	2	1871	Chain	ID=PRO_0000205762;Note=Protein RRP5 homolog
PDCD11	Q14690	1342	1382	2	1871	Chain	ID=PRO_0000205762;Note=Protein RRP5 homolog
PDCD11	Q14690	1480	1519	2	1871	Chain	ID=PRO_0000205762;Note=Protein RRP5 homolog
PDCD11	Q14690	290	326	281	346	Domain	Note=S1 motif 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180
PDCD11	Q14690	1102	1122	1036	1109	Domain	Note=S1 motif 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180
PDCD11	Q14690	1301	1341	1324	1396	Domain	Note=S1 motif 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180
PDCD11	Q14690	1342	1382	1324	1396	Domain	Note=S1 motif 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180
PDCD11	Q14690	1342	1382	1360	1360	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
PDCD11	Q14690	1342	1382	1362	1362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
PDCD11	Q14690	1480	1519	1493	1493	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PDCD11	Q14690	1480	1519	1498	1498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:23186163
SNF8	Q96H20	188	213	1	258	Chain	ID=PRO_0000215209;Note=Vacuolar-sorting protein SNF8
SNF8	Q96H20	81	116	1	258	Chain	ID=PRO_0000215209;Note=Vacuolar-sorting protein SNF8
SNF8	Q96H20	188	213	189	189	Alternative sequence	ID=VSP_015340;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNF8	Q96H20	81	116	86	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNF8	Q96H20	81	116	93	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNF8	Q96H20	81	116	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNF8	Q96H20	188	213	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNF8	Q96H20	188	213	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNF8	Q96H20	188	213	195	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNF8	Q96H20	188	213	206	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
SNAP29	O95721	173	206	1	258	Chain	ID=PRO_0000213601;Note=Synaptosomal-associated protein 29
SNAP29	O95721	173	206	196	258	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
SNAP29	O95721	173	206	182	182	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SNAP29	O95721	173	206	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SNAP29	O95721	173	206	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SNAP29	O95721	173	206	195	255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WY4
SNTG1	Q9NSN8	9	54	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	54	73	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	107	121	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	270	283	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	428	465	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	9	54	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	54	73	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	107	121	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	270	283	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	428	465	1	517	Chain	ID=PRO_0000184013;Note=Gamma-1-syntrophin
SNTG1	Q9NSN8	54	73	57	140	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SNTG1	Q9NSN8	107	121	57	140	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SNTG1	Q9NSN8	54	73	57	140	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SNTG1	Q9NSN8	107	121	57	140	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SNTG1	Q9NSN8	270	283	283	390	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SNTG1	Q9NSN8	270	283	283	390	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SNTG1	Q9NSN8	428	465	428	464	Alternative sequence	ID=VSP_006360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10747910;Dbxref=PMID:10747910
SNTG1	Q9NSN8	428	465	428	464	Alternative sequence	ID=VSP_006360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10747910;Dbxref=PMID:10747910
RMDN1	Q96DB5	165	195	1	314	Chain	ID=PRO_0000187181;Note=Regulator of microtubule dynamics protein 1
RMDN1	Q96DB5	165	195	168	204	Repeat	Note=TPR 1
RMDN1	Q96DB5	165	195	165	165	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCV4
RMDN1	Q96DB5	165	195	166	195	Alternative sequence	ID=VSP_054647;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MRPL27	Q9P0M9	13	57	1	30	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q32PC3
MRPL27	Q9P0M9	13	57	31	148	Chain	ID=PRO_0000181229;Note=39S ribosomal protein L27%2C mitochondrial
MRPL27	Q9P0M9	13	57	24	24	Natural variant	ID=VAR_052023;Note=T->A;Dbxref=dbSNP:rs17776919
MRPL27	Q9P0M9	13	57	52	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
RNF135	Q8IUD6	124	172	1	432	Chain	ID=PRO_0000280557;Note=E3 ubiquitin-protein ligase RNF135
RNF135	Q8IUD6	124	172	121	156	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF121	Q9H920	133	168	2	327	Chain	ID=PRO_0000261407;Note=RING finger protein 121
RNF121	Q9H920	254	287	2	327	Chain	ID=PRO_0000261407;Note=RING finger protein 121
RNF121	Q9H920	133	168	148	168	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF121	Q9H920	254	287	226	276	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF125	Q96EQ8	168	204	2	232	Chain	ID=PRO_0000056090;Note=E3 ubiquitin-protein ligase RNF125
RNF125	Q96EQ8	168	204	174	174	Natural variant	ID=VAR_073355;Note=In TNORS. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25196541;Dbxref=dbSNP:rs370242930,PMID:25196541
RNF125	Q96EQ8	168	204	187	187	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF181	Q9P0P0	109	134	1	153	Chain	ID=PRO_0000295174;Note=E3 ubiquitin-protein ligase RNF181
RNF181	Q9P0P0	109	134	76	117	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF181	Q9P0P0	109	134	118	118	Natural variant	ID=VAR_033323;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs6643
RNF25	Q96BH1	222	267	1	459	Chain	ID=PRO_0000056066;Note=E3 ubiquitin-protein ligase RNF25
RNF25	Q96BH1	191	222	1	459	Chain	ID=PRO_0000056066;Note=E3 ubiquitin-protein ligase RNF25
RNF25	Q96BH1	143	191	1	459	Chain	ID=PRO_0000056066;Note=E3 ubiquitin-protein ligase RNF25
RNF25	Q96BH1	191	222	135	202	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF25	Q96BH1	143	191	135	202	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF25	Q96BH1	143	191	159	159	Mutagenesis	Note=Reduced activation of NF-kappa-B. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12748188;Dbxref=PMID:12748188
RNF25	Q96BH1	143	191	161	161	Mutagenesis	Note=Strongly reduced activation of NF-kappa-B. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12748188;Dbxref=PMID:12748188
RNF25	Q96BH1	143	191	186	186	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF25	Q96BH1	143	191	148	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D1M
RNF25	Q96BH1	143	191	156	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D1M
RNF25	Q96BH1	143	191	159	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D1M
RNF25	Q96BH1	191	222	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D1M
RNF25	Q96BH1	191	222	209	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D1M
RNF25	Q96BH1	222	267	229	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D1M
POLR2K	P53803	20	51	1	58	Chain	ID=PRO_0000159750;Note=DNA-directed RNA polymerases I%2C II%2C and III subunit RPABC4
POLR2K	P53803	20	51	19	39	Zinc finger	Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
POLR2K	P53803	20	51	22	22	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR2K	P53803	20	51	36	36	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR2K	P53803	20	51	39	39	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
SMC2	O95347	56	106	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	197	212	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	557	597	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	56	106	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	197	212	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	557	597	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	56	106	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	197	212	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	557	597	1	1197	Chain	ID=PRO_0000118995;Note=Structural maintenance of chromosomes protein 2
SMC2	O95347	557	597	522	640	Domain	Note=SMC hinge
SMC2	O95347	557	597	522	640	Domain	Note=SMC hinge
SMC2	O95347	557	597	522	640	Domain	Note=SMC hinge
SMC2	O95347	197	212	173	507	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC2	O95347	197	212	173	507	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC2	O95347	197	212	173	507	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC2	O95347	557	597	557	566	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	557	566	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	557	566	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	573	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	573	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	573	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	578	580	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	578	580	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	578	580	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	588	598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	588	598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC2	O95347	557	597	588	598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
RPP40	O75818	144	186	1	363	Chain	ID=PRO_0000097434;Note=Ribonuclease P protein subunit p40
RPP40	O75818	89	112	1	363	Chain	ID=PRO_0000097434;Note=Ribonuclease P protein subunit p40
RPP40	O75818	89	112	90	112	Alternative sequence	ID=VSP_037346;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SMC3	Q9UQE7	30	43	1	1217	Chain	ID=PRO_0000119001;Note=Structural maintenance of chromosomes protein 3
SMC3	Q9UQE7	241	268	1	1217	Chain	ID=PRO_0000119001;Note=Structural maintenance of chromosomes protein 3
SMC3	Q9UQE7	809	845	1	1217	Chain	ID=PRO_0000119001;Note=Structural maintenance of chromosomes protein 3
SMC3	Q9UQE7	1035	1099	1	1217	Chain	ID=PRO_0000119001;Note=Structural maintenance of chromosomes protein 3
SMC3	Q9UQE7	30	43	32	39	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC3	Q9UQE7	241	268	179	350	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC3	Q9UQE7	809	845	669	916	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC3	Q9UQE7	1035	1099	1065	1065	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:17525332,PMID:18669648,PMID:24275569
SMC3	Q9UQE7	1035	1099	1067	1067	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17525332,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SMC3	Q9UQE7	1035	1099	1074	1074	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97690
SMC3	Q9UQE7	1035	1099	1083	1083	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
SMCHD1	A6NHR9	753	779	2	2005	Chain	ID=PRO_0000332144;Note=Structural maintenance of chromosomes flexible hinge domain-containing protein 1
SMCHD1	A6NHR9	1016	1092	2	2005	Chain	ID=PRO_0000332144;Note=Structural maintenance of chromosomes flexible hinge domain-containing protein 1
SMCHD1	A6NHR9	1211	1267	2	2005	Chain	ID=PRO_0000332144;Note=Structural maintenance of chromosomes flexible hinge domain-containing protein 1
SMCHD1	A6NHR9	1478	1522	2	2005	Chain	ID=PRO_0000332144;Note=Structural maintenance of chromosomes flexible hinge domain-containing protein 1
SMCHD1	A6NHR9	1478	1522	1499	1499	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SMCHD1	A6NHR9	1478	1522	1496	1496	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMCHD1	A6NHR9	753	779	1	1065	Alternative sequence	ID=VSP_033344;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMCHD1	A6NHR9	1016	1092	1	1065	Alternative sequence	ID=VSP_033344;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMCHD1	A6NHR9	753	779	138	2005	Natural variant	ID=VAR_078878;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1016	1092	138	2005	Natural variant	ID=VAR_078878;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1211	1267	138	2005	Natural variant	ID=VAR_078878;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	138	2005	Natural variant	ID=VAR_078878;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	753	779	195	2005	Natural variant	ID=VAR_078883;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1016	1092	195	2005	Natural variant	ID=VAR_078883;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1211	1267	195	2005	Natural variant	ID=VAR_078883;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	195	2005	Natural variant	ID=VAR_078883;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	753	779	344	2005	Natural variant	ID=VAR_078887;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1016	1092	344	2005	Natural variant	ID=VAR_078887;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1211	1267	344	2005	Natural variant	ID=VAR_078887;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	344	2005	Natural variant	ID=VAR_078887;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	753	779	434	2005	Natural variant	ID=VAR_078893;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1016	1092	434	2005	Natural variant	ID=VAR_078893;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1211	1267	434	2005	Natural variant	ID=VAR_078893;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	434	2005	Natural variant	ID=VAR_078893;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	753	779	731	2005	Natural variant	ID=VAR_078901;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1016	1092	731	2005	Natural variant	ID=VAR_078901;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1211	1267	731	2005	Natural variant	ID=VAR_078901;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	731	2005	Natural variant	ID=VAR_078901;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1016	1092	780	2005	Natural variant	ID=VAR_078903;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1211	1267	780	2005	Natural variant	ID=VAR_078903;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	780	2005	Natural variant	ID=VAR_078903;Note=In FSHD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMCHD1	A6NHR9	1478	1522	1485	1485	Natural variant	ID=VAR_080705;Note=In FSHD2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25370034;Dbxref=PMID:25370034
SMCHD1	A6NHR9	1478	1522	1487	1488	Natural variant	ID=VAR_078907;Note=In FSHD2. QP->HQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25256356;Dbxref=PMID:25256356
SMOC1	Q9H4F8	159	175	27	434	Chain	ID=PRO_0000020316;Note=SPARC-related modular calcium-binding protein 1
SMOC1	Q9H4F8	194	221	27	434	Chain	ID=PRO_0000020316;Note=SPARC-related modular calcium-binding protein 1
SMOC1	Q9H4F8	194	221	214	214	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMARCC1	Q92922	1014	1073	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	882	927	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	719	773	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	613	633	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	575	613	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	462	485	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	264	306	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	161	192	2	1105	Chain	ID=PRO_0000197115;Note=SWI/SNF complex subunit SMARCC1
SMARCC1	Q92922	462	485	449	546	Domain	Note=SWIRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00247
SMARCC1	Q92922	613	633	618	669	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
SMARCC1	Q92922	882	927	914	946	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMARCC1	Q92922	719	773	769	863	Compositional bias	Note=Glu-rich
SMARCC1	Q92922	1014	1073	977	1105	Compositional bias	Note=Pro-rich
SMARCC1	Q92922	1014	1073	1064	1064	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97496
SMARCC1	Q92922	161	192	179	179	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMARCC1	Q92922	575	613	592	592	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
SMARCC1	Q92922	719	773	739	739	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMARCC1	Q92922	613	633	622	622	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCC1	Q92922	882	927	916	916	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCC1	Q92922	462	485	465	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJK
SMARCC1	Q92922	462	485	472	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJK
SMARCC1	Q92922	462	485	484	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GJK
SMARCC1	Q92922	613	633	625	637	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUS
SMARCD1	Q96GM5	177	218	1	515	Chain	ID=PRO_0000071983;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
SMARCD1	Q96GM5	218	257	1	515	Chain	ID=PRO_0000071983;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
SMARCD1	Q96GM5	257	291	1	515	Chain	ID=PRO_0000071983;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
SMARCD1	Q96GM5	423	464	1	515	Chain	ID=PRO_0000071983;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
SMARCD1	Q96GM5	257	291	291	390	Domain	Note=SWIB
SMARCD1	Q96GM5	177	218	168	474	Region	Note=Interaction with SMARCC1 and SMARCC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12917342;Dbxref=PMID:12917342
SMARCD1	Q96GM5	218	257	168	474	Region	Note=Interaction with SMARCC1 and SMARCC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12917342;Dbxref=PMID:12917342
SMARCD1	Q96GM5	257	291	168	474	Region	Note=Interaction with SMARCC1 and SMARCC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12917342;Dbxref=PMID:12917342
SMARCD1	Q96GM5	423	464	168	474	Region	Note=Interaction with SMARCC1 and SMARCC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12917342;Dbxref=PMID:12917342
SMARCD1	Q96GM5	177	218	180	515	Region	Note=Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin%3B required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo
SMARCD1	Q96GM5	218	257	180	515	Region	Note=Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin%3B required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo
SMARCD1	Q96GM5	257	291	180	515	Region	Note=Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin%3B required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo
SMARCD1	Q96GM5	423	464	180	515	Region	Note=Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin%3B required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo
SMARCD1	Q96GM5	423	464	412	440	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMARCD1	Q96GM5	177	218	203	203	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92925
SMARCD1	Q96GM5	218	257	223	223	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61466
SMARCD1	Q96GM5	423	464	423	463	Alternative sequence	ID=VSP_004179;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8804307;Dbxref=PMID:8804307
RRAGB	Q5VZM2	75	103	1	374	Chain	ID=PRO_0000239948;Note=Ras-related GTP-binding protein B
RRAGB	Q5VZM2	200	232	1	374	Chain	ID=PRO_0000239948;Note=Ras-related GTP-binding protein B
RRAGB	Q5VZM2	200	232	203	203	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7L523
RRAGB	Q5VZM2	75	103	77	104	Alternative sequence	ID=VSP_052073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:7499430,ECO:0000303|PubMed:9394008;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005,PMID:7499430,PMID:9394008
GFM2	Q969S9	360	406	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	101	143	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	360	406	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	101	143	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	101	143	68	353	Domain	Note=tr-type G
GFM2	Q969S9	101	143	68	353	Domain	Note=tr-type G
GFM2	Q969S9	101	143	141	145	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03059
GFM2	Q969S9	101	143	141	145	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03059
GFM2	Q969S9	360	406	361	407	Alternative sequence	ID=VSP_001363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GFM2	Q969S9	360	406	361	407	Alternative sequence	ID=VSP_001363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
RAPGEF5	Q92565	325	366	1	580	Chain	ID=PRO_0000068873;Note=Rap guanine nucleotide exchange factor 5
RAPGEF5	Q92565	325	366	345	579	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RAPGEF5	Q92565	325	366	270	405	Alternative sequence	ID=VSP_007616;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SMAD1	Q15797	219	258	1	465	Chain	ID=PRO_0000090847;Note=Mothers against decapentaplegic homolog 1
SMAD1	Q15797	219	258	1	465	Chain	ID=PRO_0000090847;Note=Mothers against decapentaplegic homolog 1
SMAD1	Q15797	219	258	1	465	Chain	ID=PRO_0000090847;Note=Mothers against decapentaplegic homolog 1
SMAD1	Q15797	219	258	220	258	Alternative sequence	ID=VSP_057165;Note=In isoform 2. ADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRG->GRLECSVMFCSHIRQCYHSVTEKLGQPAVEGGFQPWYMT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMAD1	Q15797	219	258	220	258	Alternative sequence	ID=VSP_057165;Note=In isoform 2. ADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRG->GRLECSVMFCSHIRQCYHSVTEKLGQPAVEGGFQPWYMT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMAD1	Q15797	219	258	220	258	Alternative sequence	ID=VSP_057165;Note=In isoform 2. ADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRG->GRLECSVMFCSHIRQCYHSVTEKLGQPAVEGGFQPWYMT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SFMBT1	Q9UHJ3	777	820	1	866	Chain	ID=PRO_0000071966;Note=Scm-like with four MBT domains protein 1
SFMBT1	Q9UHJ3	265	299	1	866	Chain	ID=PRO_0000071966;Note=Scm-like with four MBT domains protein 1
SFMBT1	Q9UHJ3	265	299	242	348	Repeat	Note=MBT 3
SFMBT1	Q9UHJ3	777	820	796	864	Domain	Note=SAM
SFMBT1	Q9UHJ3	777	820	778	820	Alternative sequence	ID=VSP_013857;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMO	Q99835	489	550	28	787	Chain	ID=PRO_0000013015;Note=Smoothened homolog
SMO	Q99835	489	550	473	524	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMO	Q99835	489	550	525	545	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMO	Q99835	489	550	546	787	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMO	Q99835	489	550	538	569	Region	Note=Interaction with BBS5 and BBS7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22072986;Dbxref=PMID:22072986
SMO	Q99835	489	550	490	507	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00090,ECO:0000269|PubMed:23636324;Dbxref=PMID:23636324
SMO	Q99835	489	550	535	535	Natural variant	ID=VAR_007848;Note=In basal cell carcinoma and ameloblastoma samples%3B somatic mutation%3B constitutive activation of the smoothened signaling pathway. W->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24859340,ECO:0000269|PubMed:9422511;Dbxref=dbSNP:rs121918347,PMID:24859340,PMID:9422511
SMO	Q99835	489	550	443	492	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKV
SMO	Q99835	489	550	501	503	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V56
SMO	Q99835	489	550	515	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKV
SMO	Q99835	489	550	533	536	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKV
SMO	Q99835	489	550	539	548	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKV
SMARCC2	Q8TAQ2	550	590	1	1214	Chain	ID=PRO_0000197117;Note=SWI/SNF complex subunit SMARCC2
SMARCC2	Q8TAQ2	437	460	1	1214	Chain	ID=PRO_0000197117;Note=SWI/SNF complex subunit SMARCC2
SMARCC2	Q8TAQ2	360	380	1	1214	Chain	ID=PRO_0000197117;Note=SWI/SNF complex subunit SMARCC2
SMARCC2	Q8TAQ2	37	77	1	1214	Chain	ID=PRO_0000197117;Note=SWI/SNF complex subunit SMARCC2
SMARCC2	Q8TAQ2	437	460	424	521	Domain	Note=SWIRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00247
SMARCC2	Q8TAQ2	550	590	564	564	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMARCC2	Q8TAQ2	550	590	566	566	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
SMARCC2	Q8TAQ2	550	590	568	568	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMARCC2	Q8TAQ2	550	590	550	550	Alternative sequence	ID=VSP_012490;Note=In isoform 2 and isoform 3. Q->QGRQVDADTKAGRKGKELDDLVPETAKGKPEL;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SMARCC2	Q8TAQ2	550	590	587	587	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMAD2	Q15796	243	261	2	467	Chain	ID=PRO_0000090852;Note=Mothers against decapentaplegic homolog 2
SMAD2	Q15796	218	243	2	467	Chain	ID=PRO_0000090852;Note=Mothers against decapentaplegic homolog 2
SMAD2	Q15796	79	108	2	467	Chain	ID=PRO_0000090852;Note=Mothers against decapentaplegic homolog 2
SMAD2	Q15796	243	261	2	467	Chain	ID=PRO_0000090852;Note=Mothers against decapentaplegic homolog 2
SMAD2	Q15796	218	243	2	467	Chain	ID=PRO_0000090852;Note=Mothers against decapentaplegic homolog 2
SMAD2	Q15796	79	108	2	467	Chain	ID=PRO_0000090852;Note=Mothers against decapentaplegic homolog 2
SMAD2	Q15796	79	108	10	176	Domain	Note=MH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00438
SMAD2	Q15796	79	108	10	176	Domain	Note=MH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00438
SMAD2	Q15796	218	243	221	225	Motif	Note=PY-motif
SMAD2	Q15796	218	243	221	225	Motif	Note=PY-motif
SMAD2	Q15796	218	243	220	220	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	218	243	220	220	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	218	243	240	240	Modified residue	Note=Phosphoserine%3B by CAMK2;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00439,ECO:0000269|PubMed:11879191;Dbxref=PMID:11879191
SMAD2	Q15796	218	243	240	240	Modified residue	Note=Phosphoserine%3B by CAMK2;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00439,ECO:0000269|PubMed:11879191;Dbxref=PMID:11879191
SMAD2	Q15796	243	261	245	245	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	243	261	245	245	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	243	261	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	243	261	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	243	261	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	243	261	255	255	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12193595;Dbxref=PMID:12193595
SMAD2	Q15796	79	108	79	108	Alternative sequence	ID=VSP_006178;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMAD2	Q15796	79	108	79	108	Alternative sequence	ID=VSP_006178;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMAD2	Q15796	218	243	221	225	Mutagenesis	Note=Loss of binding to SMURF2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11389444;Dbxref=PMID:11389444
SMAD2	Q15796	218	243	221	225	Mutagenesis	Note=Loss of binding to SMURF2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11389444;Dbxref=PMID:11389444
SMAD5	Q99717	134	218	2	465	Chain	ID=PRO_0000090865;Note=Mothers against decapentaplegic homolog 5
SMAD5	Q99717	134	218	2	465	Chain	ID=PRO_0000090865;Note=Mothers against decapentaplegic homolog 5
SMAD5	Q99717	134	218	13	137	Domain	Note=MH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00438
SMAD5	Q99717	134	218	13	137	Domain	Note=MH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00438
SMAD5	Q99717	134	218	175	175	Sequence conflict	Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMAD5	Q99717	134	218	175	175	Sequence conflict	Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMAD7	O15105	222	247	1	426	Chain	ID=PRO_0000090872;Note=Mothers against decapentaplegic homolog 7
SMAD7	O15105	222	247	223	223	Alternative sequence	ID=VSP_047540;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMAD9	O15198	223	260	1	467	Chain	ID=PRO_0000090875;Note=Mothers against decapentaplegic homolog 9
SMAD9	O15198	137	223	1	467	Chain	ID=PRO_0000090875;Note=Mothers against decapentaplegic homolog 9
SMAD9	O15198	223	260	1	467	Chain	ID=PRO_0000090875;Note=Mothers against decapentaplegic homolog 9
SMAD9	O15198	137	223	16	140	Domain	Note=MH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00438
SMAD9	O15198	223	260	224	260	Alternative sequence	ID=VSP_006182;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205116;Dbxref=PMID:15489334,PMID:9205116
SMAD9	O15198	223	260	224	260	Alternative sequence	ID=VSP_006182;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205116;Dbxref=PMID:15489334,PMID:9205116
SAMD4A	Q9UPU9	65	238	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	238	326	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	65	238	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	238	326	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	238	326	323	391	Domain	Note=SAM
SAMD4A	Q9UPU9	238	326	323	391	Domain	Note=SAM
SAMD4A	Q9UPU9	65	238	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMD4A	Q9UPU9	65	238	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMD4A	Q9UPU9	65	238	1	101	Alternative sequence	ID=VSP_037778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SAMD4A	Q9UPU9	65	238	1	101	Alternative sequence	ID=VSP_037778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SAMD4A	Q9UPU9	238	326	239	327	Alternative sequence	ID=VSP_037779;Note=In isoform 3. ILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
SAMD4A	Q9UPU9	238	326	239	327	Alternative sequence	ID=VSP_037779;Note=In isoform 3. ILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
SAMD4A	Q9UPU9	65	238	108	108	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4A	Q9UPU9	65	238	108	108	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4A	Q9UPU9	65	238	138	138	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4A	Q9UPU9	65	238	138	138	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4B	Q5PRF9	65	222	1	694	Chain	ID=PRO_0000260080;Note=Protein Smaug homolog 2
SAMD4B	Q5PRF9	222	302	1	694	Chain	ID=PRO_0000260080;Note=Protein Smaug homolog 2
SAMD4B	Q5PRF9	339	368	1	694	Chain	ID=PRO_0000260080;Note=Protein Smaug homolog 2
SAMD4B	Q5PRF9	657	685	1	694	Chain	ID=PRO_0000260080;Note=Protein Smaug homolog 2
SAMD4B	Q5PRF9	222	302	299	372	Domain	Note=SAM
SAMD4B	Q5PRF9	339	368	299	372	Domain	Note=SAM
SAMD4B	Q5PRF9	65	222	172	172	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SAMD4B	Q5PRF9	222	302	271	271	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SAMD4B	Q5PRF9	222	302	278	278	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80XS6
SAMD4B	Q5PRF9	222	302	279	279	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80XS6
SAMD4B	Q5PRF9	222	302	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80XS6
SMARCAL1	Q9NZC9	287	365	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	365	382	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	548	570	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	748	809	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	287	365	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	365	382	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	548	570	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	748	809	2	954	Chain	ID=PRO_0000074348;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
SMARCAL1	Q9NZC9	287	365	226	303	Domain	Note=HARP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00800
SMARCAL1	Q9NZC9	287	365	226	303	Domain	Note=HARP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00800
SMARCAL1	Q9NZC9	287	365	327	398	Domain	Note=HARP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00800
SMARCAL1	Q9NZC9	365	382	327	398	Domain	Note=HARP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00800
SMARCAL1	Q9NZC9	287	365	327	398	Domain	Note=HARP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00800
SMARCAL1	Q9NZC9	365	382	327	398	Domain	Note=HARP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00800
SMARCAL1	Q9NZC9	548	570	445	600	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCAL1	Q9NZC9	548	570	445	600	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCAL1	Q9NZC9	748	809	716	869	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SMARCAL1	Q9NZC9	748	809	716	869	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SMARCAL1	Q9NZC9	548	570	549	552	Motif	Note=DESH box
SMARCAL1	Q9NZC9	548	570	549	552	Motif	Note=DESH box
SMARCAL1	Q9NZC9	287	365	315	315	Natural variant	ID=VAR_021367;Note=S->R;Dbxref=dbSNP:rs2066522
SMARCAL1	Q9NZC9	287	365	315	315	Natural variant	ID=VAR_021367;Note=S->R;Dbxref=dbSNP:rs2066522
SMARCAL1	Q9NZC9	365	382	377	377	Natural variant	ID=VAR_021368;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2066518,PMID:14702039,PMID:15489334
SMARCAL1	Q9NZC9	365	382	377	377	Natural variant	ID=VAR_021368;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2066518,PMID:14702039,PMID:15489334
SMARCAL1	Q9NZC9	548	570	548	548	Natural variant	ID=VAR_021371;Note=In SIOD. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11799392;Dbxref=dbSNP:rs119473036,PMID:11799392
SMARCAL1	Q9NZC9	548	570	548	548	Natural variant	ID=VAR_021371;Note=In SIOD. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11799392;Dbxref=dbSNP:rs119473036,PMID:11799392
SMARCAL1	Q9NZC9	748	809	764	764	Natural variant	ID=VAR_021381;Note=In SIOD%3B abolishes annealing helicase activity%3B no effect on specific binding to fork DNA%3B no effect on recruitment to sites of DNA damage. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11799392,ECO:0000269|PubMed:18974355,ECO:0000269|PubMed:19793862;Dbxref=dbSNP:rs267607071,PMID:11799392,PMID:18974355,PMID:19793862
SMARCAL1	Q9NZC9	748	809	764	764	Natural variant	ID=VAR_021381;Note=In SIOD%3B abolishes annealing helicase activity%3B no effect on specific binding to fork DNA%3B no effect on recruitment to sites of DNA damage. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11799392,ECO:0000269|PubMed:18974355,ECO:0000269|PubMed:19793862;Dbxref=dbSNP:rs267607071,PMID:11799392,PMID:18974355,PMID:19793862
SMARCAL1	Q9NZC9	287	365	335	335	Sequence conflict	Note=C->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCAL1	Q9NZC9	287	365	335	335	Sequence conflict	Note=C->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCAL1	Q9NZC9	287	365	344	344	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCAL1	Q9NZC9	287	365	344	344	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMAP1	Q8IYB5	138	165	1	467	Chain	ID=PRO_0000235838;Note=Stromal membrane-associated protein 1
SMAP1	Q8IYB5	138	165	139	165	Alternative sequence	ID=VSP_018502;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12119110,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:12119110,PMID:14702039,PMID:15489334
SMC1A	Q14683	954	991	1	1233	Chain	ID=PRO_0000118989;Note=Structural maintenance of chromosomes protein 1A
SMC1A	Q14683	686	732	1	1233	Chain	ID=PRO_0000118989;Note=Structural maintenance of chromosomes protein 1A
SMC1A	Q14683	515	577	1	1233	Chain	ID=PRO_0000118989;Note=Structural maintenance of chromosomes protein 1A
SMC1A	Q14683	515	577	515	629	Domain	Note=SMC hinge
SMC1A	Q14683	686	732	660	935	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC1A	Q14683	954	991	991	1068	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC1A	Q14683	686	732	713	713	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SMC1A	Q14683	954	991	957	957	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:11877377;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:11877377
SMC1A	Q14683	954	991	962	962	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SMC1A	Q14683	954	991	966	966	Modified residue	Note=Phosphoserine%3B by ATM and ATR;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:20068231,ECO:0000269|PubMed:11877377,ECO:0000269|PubMed:14657349,ECO:0000269|PubMed:22977523;Dbxref=PMID:17525332,PMID:20068231,PMID:11877377,PMID:14657349,PMID:22977523
SMC1A	Q14683	954	991	970	970	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SMC1A	Q14683	686	732	693	693	Natural variant	ID=VAR_062795;Note=In CDLS2. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19701948;Dbxref=PMID:19701948
SMC1A	Q14683	686	732	693	693	Natural variant	ID=VAR_078276;Note=In CDLS2. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24124034;Dbxref=dbSNP:rs587784408,PMID:24124034
SMC1A	Q14683	686	732	711	711	Natural variant	ID=VAR_064542;Note=In CDLS2. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20358602;Dbxref=dbSNP:rs782176647,PMID:20358602
SMC1A	Q14683	686	732	711	711	Natural variant	ID=VAR_062796;Note=In CDLS2. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17273969,ECO:0000269|PubMed:19701948;Dbxref=dbSNP:rs587784409,PMID:17273969,PMID:19701948
SMC1A	Q14683	954	991	957	957	Mutagenesis	Note=Reduces phosphorylation and the S-phase checkpoint activation. Abolishes S-phase activation%3B when associated with A-966. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11877377;Dbxref=PMID:11877377
SMC1A	Q14683	954	991	966	966	Mutagenesis	Note=Reduces phosphorylation and the S-phase checkpoint activation. Increases sensitivity to DNA methylation. Abolishes S-phase activation%3B when associated with A-957. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11877377,ECO:0000269|PubMed:14657349;Dbxref=PMID:11877377,PMID:14657349
SMC4	Q9NTJ3	106	170	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	229	284	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	479	557	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	557	619	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	619	673	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	980	1038	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	106	170	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	229	284	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	479	557	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	557	619	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	619	673	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	980	1038	1	1288	Chain	ID=PRO_0000119006;Note=Structural maintenance of chromosomes protein 4
SMC4	Q9NTJ3	557	619	613	727	Domain	Note=SMC hinge
SMC4	Q9NTJ3	619	673	613	727	Domain	Note=SMC hinge
SMC4	Q9NTJ3	557	619	613	727	Domain	Note=SMC hinge
SMC4	Q9NTJ3	619	673	613	727	Domain	Note=SMC hinge
SMC4	Q9NTJ3	106	170	113	120	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	106	170	113	120	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	229	284	272	588	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	479	557	272	588	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	557	619	272	588	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	229	284	272	588	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	479	557	272	588	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	557	619	272	588	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	980	1038	767	1020	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	980	1038	767	1020	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC4	Q9NTJ3	106	170	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SMC4	Q9NTJ3	106	170	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SMC4	Q9NTJ3	980	1038	982	982	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SMC4	Q9NTJ3	980	1038	982	982	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SMC4	Q9NTJ3	980	1038	980	1037	Alternative sequence	ID=VSP_007245;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMC4	Q9NTJ3	980	1038	980	1037	Alternative sequence	ID=VSP_007245;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SMC4	Q9NTJ3	229	284	272	272	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	229	284	272	272	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	229	284	283	283	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	229	284	283	283	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	557	619	594	594	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	557	619	594	594	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	619	673	645	645	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	619	673	645	645	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMC4	Q9NTJ3	557	619	573	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	557	619	573	608	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	557	619	614	618	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	557	619	614	618	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	557	619	619	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	619	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	557	619	619	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	619	622	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	627	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	627	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	630	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	630	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	638	641	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	638	641	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	642	646	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	642	646	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	648	660	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	648	660	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	665	670	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	665	670	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	671	677	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
SMC4	Q9NTJ3	619	673	671	677	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U4P
RPTOR	Q8N122	116	169	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	169	218	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	277	296	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	404	438	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	503	528	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	528	550	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	614	661	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	936	973	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	1231	1269	1	1335	Chain	ID=PRO_0000051200;Note=Regulatory-associated protein of mTOR
RPTOR	Q8N122	1231	1269	1209	1249	Repeat	Note=WD 5
RPTOR	Q8N122	1231	1269	1251	1291	Repeat	Note=WD 6
RPTOR	Q8N122	404	438	380	1335	Alternative sequence	ID=VSP_010174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPTOR	Q8N122	503	528	380	1335	Alternative sequence	ID=VSP_010174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPTOR	Q8N122	528	550	380	1335	Alternative sequence	ID=VSP_010174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPTOR	Q8N122	614	661	380	1335	Alternative sequence	ID=VSP_010174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPTOR	Q8N122	936	973	380	1335	Alternative sequence	ID=VSP_010174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPTOR	Q8N122	1231	1269	380	1335	Alternative sequence	ID=VSP_010174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPTOR	Q8N122	503	528	504	661	Alternative sequence	ID=VSP_054042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19388141;Dbxref=PMID:19388141
RPTOR	Q8N122	528	550	504	661	Alternative sequence	ID=VSP_054042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19388141;Dbxref=PMID:19388141
RPTOR	Q8N122	614	661	504	661	Alternative sequence	ID=VSP_054042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19388141;Dbxref=PMID:19388141
RPTOR	Q8N122	169	218	217	218	Sequence conflict	Note=LE->RQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLR3G	O15318	101	118	1	223	Chain	ID=PRO_0000073978;Note=DNA-directed RNA polymerase III subunit RPC7
POLR3G	O15318	101	118	1	223	Chain	ID=PRO_0000073978;Note=DNA-directed RNA polymerase III subunit RPC7
SLX4IP	Q5VYV7	9	39	1	408	Chain	ID=PRO_0000306119;Note=Protein SLX4IP
SMYD3	Q9H7B4	175	212	1	428	Chain	ID=PRO_0000218312;Note=Histone-lysine N-methyltransferase SMYD3
SMYD3	Q9H7B4	17	53	1	428	Chain	ID=PRO_0000218312;Note=Histone-lysine N-methyltransferase SMYD3
SMYD3	Q9H7B4	175	212	4	240	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SMYD3	Q9H7B4	17	53	4	240	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SMYD3	Q9H7B4	17	53	49	87	Zinc finger	Note=MYND-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134
SMYD3	Q9H7B4	175	212	205	206	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12
SMYD3	Q9H7B4	175	212	181	181	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00190,ECO:0000269|Ref.12
SMYD3	Q9H7B4	17	53	22	22	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SMYD3	Q9H7B4	17	53	1	170	Alternative sequence	ID=VSP_012416;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SMYD3	Q9H7B4	17	53	1	59	Alternative sequence	ID=VSP_035601;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMYD3	Q9H7B4	175	212	171	176	Alternative sequence	ID=VSP_012417;Note=In isoform 2. LFEAFA->MEEEEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SMYD3	Q9H7B4	17	53	12	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	17	53	29	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	17	53	36	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	17	53	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	17	53	45	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CCL
SMYD3	Q9H7B4	17	53	50	52	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	175	212	171	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	175	212	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	175	212	192	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	175	212	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD3	Q9H7B4	175	212	211	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V37
SMYD4	Q8IYR2	93	123	1	804	Chain	ID=PRO_0000227784;Note=SET and MYND domain-containing protein 4
SMYD4	Q8IYR2	93	123	112	114	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
SMYD4	Q8IYR2	93	123	101	101	Natural variant	ID=VAR_057495;Note=N->D;Dbxref=dbSNP:rs9907701
RNF34	Q969K3	75	211	1	372	Chain	ID=PRO_0000056072;Note=E3 ubiquitin-protein ligase RNF34
RNF34	Q969K3	75	211	115	134	Domain	Note=SAP 1
RNF34	Q969K3	75	211	56	107	Zinc finger	Note=FYVE-type
RNF34	Q969K3	75	211	169	169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RNF34	Q969K3	75	211	183	183	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPAP2	Q8IXW5	540	562	2	612	Chain	ID=PRO_0000250648;Note=Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
RPAP2	Q8IXW5	563	612	2	612	Chain	ID=PRO_0000250648;Note=Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
RPAP2	Q8IXW5	563	612	563	596	Alternative sequence	ID=VSP_020680;Note=In isoform 2. LLTPILGIQKHSQEGMVFTRFLDTLLEELHLKNE->FLLNVKTRIKTFMMIYFHLMNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPAP2	Q8IXW5	563	612	597	612	Alternative sequence	ID=VSP_020681;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPN2	P04844	69	101	23	631	Chain	ID=PRO_0000022244;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
RPN2	P04844	230	289	23	631	Chain	ID=PRO_0000022244;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
RPN2	P04844	498	527	23	631	Chain	ID=PRO_0000022244;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
RPN2	P04844	527	559	23	631	Chain	ID=PRO_0000022244;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
RPN2	P04844	69	101	23	540	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN2	P04844	230	289	23	540	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN2	P04844	498	527	23	540	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN2	P04844	527	559	23	540	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN2	P04844	527	559	541	561	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPN2	P04844	69	101	70	101	Alternative sequence	ID=VSP_043051;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPN2	P04844	230	289	260	260	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPN2	P04844	230	289	286	286	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAPGEF2	Q9Y4G8	1389	1491	1	1499	Chain	ID=PRO_0000068865;Note=Rap guanine nucleotide exchange factor 2
RAPGEF2	Q9Y4G8	1389	1491	1406	1406	Mutagenesis	Note=Abolishes interaction with NEDD4 and NEDD4-induced ubiquitination and degradation%3B when associated with A-1428. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11598133;Dbxref=PMID:11598133
RAPGEF2	Q9Y4G8	1389	1491	1428	1428	Mutagenesis	Note=Abolishes interaction with NEDD4 and NEDD4-induced ubiquitination and degradation%3B when associated with A-1406. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11598133;Dbxref=PMID:11598133
SLFN13	Q68D06	355	399	1	897	Chain	ID=PRO_0000282985;Note=Schlafen family member 13
SLFN13	Q68D06	355	399	1	897	Chain	ID=PRO_0000282985;Note=Schlafen family member 13
SLFN13	Q68D06	355	399	1	897	Chain	ID=PRO_0000282985;Note=Schlafen family member 13
SLFN13	Q68D06	355	399	1	897	Chain	ID=PRO_0000282985;Note=Schlafen family member 13
SLFN13	Q68D06	355	399	2	355	Region	Note=N'-domain region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U311
SLFN13	Q68D06	355	399	2	355	Region	Note=N'-domain region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U311
SLFN13	Q68D06	355	399	2	355	Region	Note=N'-domain region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U311
SLFN13	Q68D06	355	399	2	355	Region	Note=N'-domain region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U311
SLFNL1	Q499Z3	319	367	1	407	Chain	ID=PRO_0000282998;Note=Schlafen-like protein 1
SLFNL1	Q499Z3	319	367	1	407	Chain	ID=PRO_0000282998;Note=Schlafen-like protein 1
SLFNL1	Q499Z3	319	367	1	407	Chain	ID=PRO_0000282998;Note=Schlafen-like protein 1
SLFNL1	Q499Z3	319	367	366	398	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SLFNL1	Q499Z3	319	367	366	398	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SLFNL1	Q499Z3	319	367	366	398	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SLFNL1	Q499Z3	319	367	261	407	Alternative sequence	ID=VSP_024277;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLFNL1	Q499Z3	319	367	261	407	Alternative sequence	ID=VSP_024277;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLFNL1	Q499Z3	319	367	261	407	Alternative sequence	ID=VSP_024277;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLFNL1	Q499Z3	319	367	320	367	Alternative sequence	ID=VSP_024278;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLFNL1	Q499Z3	319	367	320	367	Alternative sequence	ID=VSP_024278;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLFNL1	Q499Z3	319	367	320	367	Alternative sequence	ID=VSP_024278;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SMYD5	Q6GMV2	179	214	1	418	Chain	ID=PRO_0000227788;Note=SET and MYND domain-containing protein 5
SMYD5	Q6GMV2	294	313	1	418	Chain	ID=PRO_0000227788;Note=SET and MYND domain-containing protein 5
SMYD5	Q6GMV2	179	214	21	352	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SMYD5	Q6GMV2	294	313	21	352	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SMYD5	Q6GMV2	179	214	200	203	Compositional bias	Note=Poly-Glu
RBKS	Q9H477	116	171	1	322	Chain	ID=PRO_0000080092;Note=Ribokinase
RBKS	Q9H477	116	171	154	154	Binding site	Note=Substrate;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P0A9J6,ECO:0000255|HAMAP-Rule:MF_03215
RBKS	Q9H477	116	171	119	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RBKS	Q9H477	116	171	126	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RBKS	Q9H477	116	171	133	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RBKS	Q9H477	116	171	140	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RBKS	Q9H477	116	171	147	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RBKS	Q9H477	116	171	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RBKS	Q9H477	116	171	157	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C40
RANBP2	P49792	2832	2866	1	3224	Chain	ID=PRO_0000204913;Note=E3 SUMO-protein ligase RanBP2
RANBP2	P49792	2832	2866	2840	2841	Repeat	Note=16;Ontology_term=ECO:0000305;evidence=ECO:0000305
RANBP2	P49792	2832	2866	2842	2843	Repeat	Note=17;Ontology_term=ECO:0000305;evidence=ECO:0000305
RANBP2	P49792	2832	2866	2863	2864	Repeat	Note=18;Ontology_term=ECO:0000305;evidence=ECO:0000305
RANBP2	P49792	2832	2866	1001	3206	Region	Note=22 X 2 AA repeats of F-G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBM39	Q14498	391	408	2	530	Chain	ID=PRO_0000081814;Note=RNA-binding protein 39
RBM39	Q14498	365	391	2	530	Chain	ID=PRO_0000081814;Note=RNA-binding protein 39
RBM39	Q14498	275	297	2	530	Chain	ID=PRO_0000081814;Note=RNA-binding protein 39
RBM39	Q14498	229	275	2	530	Chain	ID=PRO_0000081814;Note=RNA-binding protein 39
RBM39	Q14498	121	138	2	530	Chain	ID=PRO_0000081814;Note=RNA-binding protein 39
RBM39	Q14498	99	120	2	530	Chain	ID=PRO_0000081814;Note=RNA-binding protein 39
RBM39	Q14498	229	275	153	230	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM39	Q14498	275	297	250	328	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM39	Q14498	229	275	250	328	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM39	Q14498	391	408	291	406	Region	Note=Interaction with JUN;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	365	391	291	406	Region	Note=Interaction with JUN;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	275	297	291	406	Region	Note=Interaction with JUN;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	275	297	291	355	Region	Note=Activating domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	391	408	355	406	Region	Note=Interaction with ESR1 and ESR2;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	365	391	355	406	Region	Note=Interaction with ESR1 and ESR2;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	391	408	406	530	Region	Note=Interaction with NCOA6;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM39	Q14498	99	120	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
RBM39	Q14498	99	120	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBM39	Q14498	121	138	121	121	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBM39	Q14498	121	138	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
RBM39	Q14498	99	120	111	111	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM39	Q14498	99	120	119	119	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM39	Q14498	229	275	244	244	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBM39	Q14498	121	138	100	121	Alternative sequence	ID=VSP_043375;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RBM39	Q14498	99	120	100	121	Alternative sequence	ID=VSP_043375;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RBM39	Q14498	391	408	392	397	Alternative sequence	ID=VSP_005820;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8227358;Dbxref=PMID:8227358
RBM39	Q14498	229	275	235	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM39	Q14498	229	275	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM39	Q14498	229	275	263	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM39	Q14498	229	275	271	273	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM39	Q14498	275	297	276	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM39	Q14498	275	297	285	287	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM39	Q14498	275	297	290	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JRS
RBM42	Q9BTD8	147	169	2	480	Chain	ID=PRO_0000307750;Note=RNA-binding protein 42
RBM42	Q9BTD8	228	339	2	480	Chain	ID=PRO_0000307750;Note=RNA-binding protein 42
RBM42	Q9BTD8	378	443	2	480	Chain	ID=PRO_0000307750;Note=RNA-binding protein 42
RBM42	Q9BTD8	378	443	381	459	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM42	Q9BTD8	228	339	236	480	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM42	Q9BTD8	378	443	236	480	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBM42	Q9BTD8	228	339	180	343	Compositional bias	Note=Pro-rich
RBM42	Q9BTD8	147	169	153	153	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM42	Q9BTD8	147	169	158	158	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM42	Q9BTD8	147	169	168	168	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM42	Q9BTD8	147	169	147	180	Alternative sequence	ID=VSP_037256;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RBM42	Q9BTD8	147	169	147	176	Alternative sequence	ID=VSP_028817;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBM42	Q9BTD8	147	169	147	175	Alternative sequence	ID=VSP_028818;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RNFT1	Q5M7Z0	357	391	1	435	Chain	ID=PRO_0000320635;Note=E3 ubiquitin-protein ligase RNFT1
RNFT1	Q5M7Z0	357	391	375	413	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNFT1	Q5M7Z0	357	391	368	419	Region	Note=Required for ubiquitin ligase activity and for protection against ER stress-induced cell death;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27485036;Dbxref=PMID:27485036
RNFT1	Q5M7Z0	357	391	204	435	Alternative sequence	ID=VSP_031699;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
RNFT1	Q5M7Z0	357	391	246	435	Alternative sequence	ID=VSP_031701;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RNFT1	Q5M7Z0	357	391	375	375	Mutagenesis	Note=Decreased ubiquitin ligase activity%3B when associated with S-378. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27485036;Dbxref=PMID:27485036
RNFT1	Q5M7Z0	357	391	378	378	Mutagenesis	Note=Decreased ubiquitin ligase activity%3B when associated with S-375. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27485036;Dbxref=PMID:27485036
RNFT2	Q96EX2	344	366	1	444	Chain	ID=PRO_0000279508;Note=RING finger and transmembrane domain-containing protein 2
RNFT2	Q96EX2	344	366	1	444	Chain	ID=PRO_0000279508;Note=RING finger and transmembrane domain-containing protein 2
RNFT2	Q96EX2	344	366	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNFT2	Q96EX2	344	366	330	350	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNFT2	Q96EX2	344	366	351	444	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNFT2	Q96EX2	344	366	351	444	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNFT2	Q96EX2	344	366	322	444	Alternative sequence	ID=VSP_023466;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RNFT2	Q96EX2	344	366	322	444	Alternative sequence	ID=VSP_023466;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RASGRF2	O14827	613	695	1	1237	Chain	ID=PRO_0000312863;Note=Ras-specific guanine nucleotide-releasing factor 2
RASGRF2	O14827	1184	1207	1	1237	Chain	ID=PRO_0000312863;Note=Ras-specific guanine nucleotide-releasing factor 2
RASGRF2	O14827	613	695	635	756	Domain	Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135
RASGRF2	O14827	1184	1207	1002	1234	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RHBDL3	P58872	45	98	1	404	Chain	ID=PRO_0000206177;Note=Rhomboid-related protein 3
RHBDL3	P58872	45	98	34	69	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RHBDL3	P58872	45	98	70	105	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RHBDL3	P58872	45	98	1	98	Alternative sequence	ID=VSP_056259;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RHBDL3	P58872	45	98	38	45	Alternative sequence	ID=VSP_056260;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGAP36	Q6ZRI8	84	106	41	547	Chain	ID=PRO_0000256699;Note=Rho GTPase-activating protein 36
ARHGAP36	Q6ZRI8	84	106	1	136	Alternative sequence	ID=VSP_021357;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGAP22	Q7Z5H3	107	150	1	698	Chain	ID=PRO_0000280469;Note=Rho GTPase-activating protein 22
ARHGAP22	Q7Z5H3	107	150	37	145	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGAP22	Q7Z5H3	107	150	1	329	Alternative sequence	ID=VSP_023703;Note=In isoform 4. MLSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIME->MGQPREFWHLRSQVPVPTCHLLTVQPWCLLPHPTPAGGRERRHSASSLLAALCLRKAVLRPHPAVLPGVGGCVVLSSGRMKAPLRGGLALGTGPAPTKLQLLHDWQSEPGPSGWQQGPSPPLFPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
ARHGAP22	Q7Z5H3	107	150	1	107	Alternative sequence	ID=VSP_023704;Note=In isoform 3. MLSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISP->MPFWPIRCLKRSRRMPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGAP22	Q7Z5H3	107	150	150	150	Alternative sequence	ID=VSP_023705;Note=In isoform 2. G->GGTARRSHAHPLEPLPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RHOD	O00212	110	155	1	207	Chain	ID=PRO_0000198863;Note=Rho-related GTP-binding protein RhoD
RHOD	O00212	110	155	129	132	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RHOD	O00212	110	155	134	134	Natural variant	ID=VAR_058408;Note=C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9116026,ECO:0000269|Ref.2;Dbxref=dbSNP:rs4930409,PMID:15489334,PMID:9116026
RHOD	O00212	110	155	111	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J1L
RHOD	O00212	110	155	124	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J1L
RHOD	O00212	110	155	131	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J1L
RHOD	O00212	110	155	137	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J1L
RHOD	O00212	110	155	153	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J1L
RHOJ	Q9H4E5	79	134	1	211	Chain	ID=PRO_0000198869;Note=Rho-related GTP-binding protein RhoJ
RHOJ	Q9H4E5	79	134	75	79	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RHOJ	Q9H4E5	79	134	133	136	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RHOJ	Q9H4E5	79	134	113	134	Alternative sequence	ID=VSP_007231;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RHPN1	Q8TCX5	59	101	1	670	Chain	ID=PRO_0000218895;Note=Rhophilin-1
RHPN1	Q8TCX5	367	405	1	670	Chain	ID=PRO_0000218895;Note=Rhophilin-1
RHPN1	Q8TCX5	545	599	1	670	Chain	ID=PRO_0000218895;Note=Rhophilin-1
RHPN1	Q8TCX5	59	101	23	97	Domain	Note=REM-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01207
RHPN1	Q8TCX5	367	405	108	457	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
RHPN1	Q8TCX5	545	599	513	592	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
POLR3A	O14802	1198	1253	1	1390	Chain	ID=PRO_0000073947;Note=DNA-directed RNA polymerase III subunit RPC1
POLR3A	O14802	1112	1143	1	1390	Chain	ID=PRO_0000073947;Note=DNA-directed RNA polymerase III subunit RPC1
POLR3A	O14802	872	929	1	1390	Chain	ID=PRO_0000073947;Note=DNA-directed RNA polymerase III subunit RPC1
POLR3A	O14802	477	524	1	1390	Chain	ID=PRO_0000073947;Note=DNA-directed RNA polymerase III subunit RPC1
POLR3A	O14802	477	524	499	499	Metal binding	Note=Magnesium%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR3A	O14802	477	524	501	501	Metal binding	Note=Magnesium%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR3A	O14802	477	524	503	503	Metal binding	Note=Magnesium%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR3A	O14802	872	929	897	897	Natural variant	ID=VAR_067004;Note=In HLD7. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22036171;Dbxref=dbSNP:rs267608681,PMID:22036171
POLR3A	O14802	1198	1253	1247	1247	Natural variant	ID=VAR_066524;Note=In HLD7. T->TT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21855841;Dbxref=PMID:21855841
RIOK1	Q9BRS2	229	255	1	568	Chain	ID=PRO_0000213526;Note=Serine/threonine-protein kinase RIO1
RIOK1	Q9BRS2	463	481	1	568	Chain	ID=PRO_0000213526;Note=Serine/threonine-protein kinase RIO1
RIOK1	Q9BRS2	229	255	180	479	Domain	Note=Protein kinase
RIOK1	Q9BRS2	463	481	180	479	Domain	Note=Protein kinase
RIOK1	Q9BRS2	229	255	246	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OTP
ROBO4	Q8WZ75	733	811	28	1007	Chain	ID=PRO_0000031040;Note=Roundabout homolog 4
ROBO4	Q8WZ75	439	501	28	1007	Chain	ID=PRO_0000031040;Note=Roundabout homolog 4
ROBO4	Q8WZ75	439	501	347	442	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
ROBO4	Q8WZ75	733	811	715	784	Compositional bias	Note=Pro/Ser-rich
ROBO4	Q8WZ75	733	811	805	805	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ROBO4	Q8WZ75	439	501	498	498	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL18	Q07020	1	30	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12962325;Dbxref=PMID:12962325
RPL18	Q07020	66	99	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
RPL18	Q07020	30	66	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
RPL18	Q07020	1	30	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
RPL18	Q07020	30	66	1	30	Alternative sequence	ID=VSP_055170;Note=In isoform 2. MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL18	Q07020	1	30	1	30	Alternative sequence	ID=VSP_055170;Note=In isoform 2. MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL18	Q07020	30	66	62	62	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGAP42	A6NI28	128	162	1	874	Chain	ID=PRO_0000342407;Note=Rho GTPase-activating protein 42
ARHGAP42	A6NI28	199	234	1	874	Chain	ID=PRO_0000342407;Note=Rho GTPase-activating protein 42
ARHGAP42	A6NI28	798	818	1	874	Chain	ID=PRO_0000342407;Note=Rho GTPase-activating protein 42
ARHGAP42	A6NI28	128	162	7	262	Domain	Note=BAR
ARHGAP42	A6NI28	199	234	7	262	Domain	Note=BAR
ARHGAP42	A6NI28	798	818	816	874	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ARHGAP42	A6NI28	199	234	225	261	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARHGAP42	A6NI28	798	818	811	811	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ARHGAP21	Q5T5U3	165	175	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21
ARHGAP21	Q5T5U3	165	175	165	174	Alternative sequence	ID=VSP_028298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ARHGAP26	Q9UNA1	128	162	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	162	199	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	199	234	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	381	403	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	663	754	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	128	162	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	162	199	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	199	234	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	381	403	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	663	699	1	814	Chain	ID=PRO_0000056718;Note=Rho GTPase-activating protein 26
ARHGAP26	Q9UNA1	381	403	383	568	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP26	Q9UNA1	381	403	383	568	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARHGAP26	Q9UNA1	663	754	584	701	Compositional bias	Note=Ser-rich
ARHGAP26	Q9UNA1	663	699	584	701	Compositional bias	Note=Ser-rich
ARHGAP26	Q9UNA1	663	754	700	754	Alternative sequence	ID=VSP_001659;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RINT1	Q6NUQ1	172	229	1	792	Chain	ID=PRO_0000097349;Note=RAD50-interacting protein 1
RINT1	Q6NUQ1	172	229	220	792	Domain	Note=RINT1/TIP20;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00717
RPL10	P27635	27	63	2	214	Chain	ID=PRO_0000147105;Note=60S ribosomal protein L10
RPL10	P27635	27	63	2	214	Chain	ID=PRO_0000147105;Note=60S ribosomal protein L10
RPL10	P27635	27	63	32	32	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL10	P27635	27	63	32	32	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL10	P27635	27	63	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	62	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	62	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RFC1	P35251	214	240	1	1148	Chain	ID=PRO_0000121772;Note=Replication factor C subunit 1
RFC1	P35251	188	214	1	1148	Chain	ID=PRO_0000121772;Note=Replication factor C subunit 1
RFC1	P35251	188	214	190	190	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
RFC2	P35250	280	318	1	354	Chain	ID=PRO_0000121766;Note=Replication factor C subunit 2
RFC2	P35250	253	280	1	354	Chain	ID=PRO_0000121766;Note=Replication factor C subunit 2
RFC2	P35250	111	144	1	354	Chain	ID=PRO_0000121766;Note=Replication factor C subunit 2
RFC2	P35250	61	75	1	354	Chain	ID=PRO_0000121766;Note=Replication factor C subunit 2
RFC2	P35250	280	318	304	304	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RFC2	P35250	111	144	111	144	Alternative sequence	ID=VSP_005660;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RFT1	Q96AA3	258	275	1	541	Chain	ID=PRO_0000311286;Note=Protein RFT1 homolog
RFT1	Q96AA3	186	232	1	541	Chain	ID=PRO_0000311286;Note=Protein RFT1 homolog
RFT1	Q96AA3	50	88	1	541	Chain	ID=PRO_0000311286;Note=Protein RFT1 homolog
RFT1	Q96AA3	50	88	42	62	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RFT1	Q96AA3	50	88	85	105	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RFT1	Q96AA3	186	232	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RFT1	Q96AA3	50	88	67	67	Natural variant	ID=VAR_044334;Note=In CDG1N. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18313027,ECO:0000269|PubMed:19701946;Dbxref=dbSNP:rs118203913,PMID:18313027,PMID:19701946
RFTN1	Q14699	275	343	2	578	Chain	ID=PRO_0000050718;Note=Raftlin
RGS10	O43665	77	125	1	173	Chain	ID=PRO_0000204207;Note=Regulator of G-protein signaling 10
RGS10	O43665	48	77	1	173	Chain	ID=PRO_0000204207;Note=Regulator of G-protein signaling 10
RGS10	O43665	77	125	33	148	Domain	Note=RGS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
RGS10	O43665	48	77	33	148	Domain	Note=RGS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
RGS10	O43665	48	77	66	66	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10608901;Dbxref=PMID:10608901
RGS10	O43665	77	125	94	94	Natural variant	ID=VAR_011896;Note=A->V;Dbxref=dbSNP:rs1802228
RGS10	O43665	48	77	41	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHB
RGS10	O43665	48	77	58	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHB
RGS10	O43665	77	125	75	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHB
RGS10	O43665	48	77	75	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHB
RGS10	O43665	77	125	94	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I59
RGS10	O43665	77	125	103	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLR
RGS10	O43665	77	125	108	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLR
RGS10	O43665	77	125	116	119	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHB
RGS10	O43665	77	125	120	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHB
RGS11	O94810	196	219	1	467	Chain	ID=PRO_0000204210;Note=Regulator of G-protein signaling 11
RGS11	O94810	196	219	219	282	Domain	Note=G protein gamma
RGP1	Q92546	112	162	1	391	Chain	ID=PRO_0000050741;Note=RAB6A-GEF complex partner protein 2
RHBDD1	Q8TEB9	218	237	1	315	Chain	ID=PRO_0000254189;Note=Rhomboid-related protein 4
RHBDD1	Q8TEB9	237	285	1	315	Chain	ID=PRO_0000254189;Note=Rhomboid-related protein 4
RHBDD1	Q8TEB9	218	237	1	315	Chain	ID=PRO_0000254189;Note=Rhomboid-related protein 4
RHBDD1	Q8TEB9	237	285	1	315	Chain	ID=PRO_0000254189;Note=Rhomboid-related protein 4
RHBDD1	Q8TEB9	218	237	202	315	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD1	Q8TEB9	237	285	202	315	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD1	Q8TEB9	218	237	202	315	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD1	Q8TEB9	237	285	202	315	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD1	Q8TEB9	237	285	269	284	Region	Note=Ubiquitin-binding domain (UBD);Ontology_term=ECO:0000250;evidence=ECO:0000250
RHBDD1	Q8TEB9	237	285	269	284	Region	Note=Ubiquitin-binding domain (UBD);Ontology_term=ECO:0000250;evidence=ECO:0000250
RHBDD1	Q8TEB9	218	237	210	218	Alternative sequence	ID=VSP_021204;Note=In isoform 2. LKKIMEACA->MPVFLFKPK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RHBDD1	Q8TEB9	218	237	210	218	Alternative sequence	ID=VSP_021204;Note=In isoform 2. LKKIMEACA->MPVFLFKPK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RHBDD1	Q8TEB9	237	285	263	263	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHBDD1	Q8TEB9	237	285	263	263	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RHBDF1	Q96CC6	465	519	1	855	Chain	ID=PRO_0000340104;Note=Inactive rhomboid protein 1
RHBDF1	Q96CC6	465	519	433	655	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHOBTB3	O94955	227	349	1	611	Chain	ID=PRO_0000198964;Note=Rho-related BTB domain-containing protein 3
RHOBTB3	O94955	427	485	1	611	Chain	ID=PRO_0000198964;Note=Rho-related BTB domain-containing protein 3
RHOBTB3	O94955	227	349	254	356	Domain	Note=BTB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
RHOBTB3	O94955	427	485	420	487	Domain	Note=BTB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
RHOBTB3	O94955	427	485	420	611	Region	Note=Interaction with Rab9
RHOBTB3	O94955	227	349	262	262	Natural variant	ID=VAR_018482;Note=N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10048485,ECO:0000269|PubMed:12426103;Dbxref=dbSNP:rs34899,PMID:10048485,PMID:12426103
RHOQ	P17081	67	122	1	202	Chain	ID=PRO_0000198871;Note=Rho-related GTP-binding protein RhoQ
RHOQ	P17081	122	154	1	202	Chain	ID=PRO_0000198871;Note=Rho-related GTP-binding protein RhoQ
RHOQ	P17081	67	122	63	67	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RHOQ	P17081	67	122	121	124	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RHOQ	P17081	122	154	121	124	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RHOQ	P17081	67	122	67	67	Mutagenesis	Note=Constitutively active. Interacts with PARD6 proteins and GOPC. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10934474;Dbxref=PMID:10934474
RHOQ	P17081	67	122	67	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	67	122	71	73	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	67	122	74	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	67	122	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	67	122	93	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	67	122	103	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	67	122	116	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	122	154	129	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	122	154	136	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
RHOQ	P17081	122	154	145	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ATX
ROBO3	Q96MS0	995	1060	21	1386	Chain	ID=PRO_0000031038;Note=Roundabout homolog 3
ROBO3	Q96MS0	1265	1319	21	1386	Chain	ID=PRO_0000031038;Note=Roundabout homolog 3
ROBO3	Q96MS0	995	1060	913	1386	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROBO3	Q96MS0	1265	1319	913	1386	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROBO3	Q96MS0	995	1060	1025	1034	Alternative sequence	ID=VSP_010650;Note=In isoform 2. AGEELQTFHG->LTTPLLILTT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ROBO3	Q96MS0	995	1060	1035	1386	Alternative sequence	ID=VSP_010651;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ROBO3	Q96MS0	1265	1319	1035	1386	Alternative sequence	ID=VSP_010651;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RECQL	P46063	5	71	1	649	Chain	ID=PRO_0000205049;Note=ATP-dependent DNA helicase Q1
RECQL	P46063	5	71	1	649	Chain	ID=PRO_0000205049;Note=ATP-dependent DNA helicase Q1
RECQL	P46063	5	71	65	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V1X
RECQL	P46063	5	71	65	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V1X
RALGPS2	Q86X27	19	54	1	583	Chain	ID=PRO_0000322600;Note=Ras-specific guanine nucleotide-releasing factor RalGPS2
RALGPS2	Q86X27	99	129	1	583	Chain	ID=PRO_0000322600;Note=Ras-specific guanine nucleotide-releasing factor RalGPS2
RALGPS2	Q86X27	129	160	1	583	Chain	ID=PRO_0000322600;Note=Ras-specific guanine nucleotide-releasing factor RalGPS2
RALGPS2	Q86X27	202	248	1	583	Chain	ID=PRO_0000322600;Note=Ras-specific guanine nucleotide-releasing factor RalGPS2
RALGPS2	Q86X27	416	441	1	583	Chain	ID=PRO_0000322600;Note=Ras-specific guanine nucleotide-releasing factor RalGPS2
RALGPS2	Q86X27	477	508	1	583	Chain	ID=PRO_0000322600;Note=Ras-specific guanine nucleotide-releasing factor RalGPS2
RALGPS2	Q86X27	19	54	49	287	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RALGPS2	Q86X27	99	129	49	287	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RALGPS2	Q86X27	129	160	49	287	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RALGPS2	Q86X27	202	248	49	287	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RALGPS2	Q86X27	477	508	457	569	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
RALGPS2	Q86X27	477	508	459	583	Region	Note=Required for stimulation of nucleotide exchange by RALA;Ontology_term=ECO:0000250;evidence=ECO:0000250
RALGPS2	Q86X27	416	441	422	422	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RALGPS2	Q86X27	416	441	280	583	Alternative sequence	ID=VSP_031971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RALGPS2	Q86X27	477	508	280	583	Alternative sequence	ID=VSP_031971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RALGPS2	Q86X27	416	441	416	441	Alternative sequence	ID=VSP_054909;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RALGPS2	Q86X27	202	248	225	225	Natural variant	ID=VAR_039468;Note=N->S;Dbxref=dbSNP:rs35161510
RASGRF1	Q13972	1088	1154	1	1273	Chain	ID=PRO_0000068880;Note=Ras-specific guanine nucleotide-releasing factor 1
RASGRF1	Q13972	874	931	1	1273	Chain	ID=PRO_0000068880;Note=Ras-specific guanine nucleotide-releasing factor 1
RASGRF1	Q13972	832	874	1	1273	Chain	ID=PRO_0000068880;Note=Ras-specific guanine nucleotide-releasing factor 1
RASGRF1	Q13972	609	621	1	1273	Chain	ID=PRO_0000068880;Note=Ras-specific guanine nucleotide-releasing factor 1
RASGRF1	Q13972	1088	1154	1038	1270	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
RASGRF1	Q13972	609	621	1	784	Alternative sequence	ID=VSP_012032;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7684828;Dbxref=PMID:7684828
RASGRF1	Q13972	609	621	610	622	Alternative sequence	ID=VSP_054072;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RASGRF1	Q13972	1088	1154	1111	1111	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RASGRF1	Q13972	1088	1154	1134	1134	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
HNRNPA1	P09651	5	44	1	372	Chain	ID=PRO_0000424509;Note=Heterogeneous nuclear ribonucleoprotein A1
HNRNPA1	P09651	44	93	1	372	Chain	ID=PRO_0000424509;Note=Heterogeneous nuclear ribonucleoprotein A1
HNRNPA1	P09651	194	225	1	372	Chain	ID=PRO_0000424509;Note=Heterogeneous nuclear ribonucleoprotein A1
HNRNPA1	P09651	250	302	1	372	Chain	ID=PRO_0000424509;Note=Heterogeneous nuclear ribonucleoprotein A1
HNRNPA1	P09651	5	44	2	372	Chain	ID=PRO_0000081828;Note=Heterogeneous nuclear ribonucleoprotein A1%2C N-terminally processed
HNRNPA1	P09651	44	93	2	372	Chain	ID=PRO_0000081828;Note=Heterogeneous nuclear ribonucleoprotein A1%2C N-terminally processed
HNRNPA1	P09651	194	225	2	372	Chain	ID=PRO_0000081828;Note=Heterogeneous nuclear ribonucleoprotein A1%2C N-terminally processed
HNRNPA1	P09651	250	302	2	372	Chain	ID=PRO_0000081828;Note=Heterogeneous nuclear ribonucleoprotein A1%2C N-terminally processed
HNRNPA1	P09651	5	44	14	97	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA1	P09651	44	93	14	97	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA1	P09651	5	44	4	94	Region	Note=Globular A domain
HNRNPA1	P09651	44	93	4	94	Region	Note=Globular A domain
HNRNPA1	P09651	194	225	218	240	Region	Note=RNA-binding RGG-box
HNRNPA1	P09651	194	225	195	372	Compositional bias	Note=Gly-rich
HNRNPA1	P09651	250	302	195	372	Compositional bias	Note=Gly-rich
HNRNPA1	P09651	5	44	6	6	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
HNRNPA1	P09651	5	44	22	22	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49312
HNRNPA1	P09651	194	225	194	194	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09867
HNRNPA1	P09651	194	225	194	194	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15782174;Dbxref=PMID:15782174
HNRNPA1	P09651	194	225	194	194	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49312
HNRNPA1	P09651	194	225	199	199	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
HNRNPA1	P09651	194	225	206	206	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.9;Dbxref=PMID:24129315
HNRNPA1	P09651	194	225	206	206	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15782174;Dbxref=PMID:15782174
HNRNPA1	P09651	194	225	206	206	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.9;Dbxref=PMID:24129315
HNRNPA1	P09651	194	225	218	218	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA1	P09651	194	225	218	218	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA1	P09651	194	225	225	225	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.9;Dbxref=PMID:24129315
HNRNPA1	P09651	194	225	225	225	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15782174;Dbxref=PMID:15782174
HNRNPA1	P09651	194	225	225	225	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.9;Dbxref=PMID:24129315
HNRNPA1	P09651	5	44	8	8	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
HNRNPA1	P09651	44	93	78	78	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HNRNPA1	P09651	194	225	203	307	Alternative sequence	ID=VSP_034076;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HNRNPA1	P09651	250	302	203	307	Alternative sequence	ID=VSP_034076;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HNRNPA1	P09651	250	302	252	303	Alternative sequence	ID=VSP_005824;Note=In isoform A1-A. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2836799,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334,PMID:2836799
HNRNPA1	P09651	250	302	277	277	Natural variant	ID=VAR_077531;Note=In ALS20%3B unknown pathological significance. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27694260;Dbxref=PMID:27694260
HNRNPA1	P09651	250	302	283	283	Natural variant	ID=VAR_077532;Note=Probable polymorphism. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27694260;Dbxref=dbSNP:rs375259222,PMID:27694260
HNRNPA1	P09651	5	44	11	14	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	5	44	15	20	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	5	44	27	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	5	44	35	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	5	44	40	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	44	93	40	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	44	93	49	51	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	44	93	54	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	44	93	65	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA1	P09651	44	93	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U1R
HNRNPA1	P09651	44	93	85	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L3K
HNRNPA2B1	P22626	292	333	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	252	292	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	231	252	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	204	231	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	170	204	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	51	100	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	2	14	1	353	Chain	ID=PRO_0000081836;Note=Heterogeneous nuclear ribonucleoproteins A2/B1
HNRNPA2B1	P22626	51	100	21	104	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA2B1	P22626	170	204	112	191	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA2B1	P22626	292	333	193	353	Region	Note=Low complexity (LC) region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	193	353	Region	Note=Low complexity (LC) region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	231	252	193	353	Region	Note=Low complexity (LC) region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	204	231	193	353	Region	Note=Low complexity (LC) region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	170	204	193	353	Region	Note=Low complexity (LC) region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	308	347	Region	Note=Nuclear targeting sequence;Ontology_term=ECO:0000250;evidence=ECO:0000250
HNRNPA2B1	P22626	2	14	9	15	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
HNRNPA2B1	P22626	292	333	202	353	Compositional bias	Note=Gly-rich
HNRNPA2B1	P22626	252	292	202	353	Compositional bias	Note=Gly-rich
HNRNPA2B1	P22626	231	252	202	353	Compositional bias	Note=Gly-rich
HNRNPA2B1	P22626	204	231	202	353	Compositional bias	Note=Gly-rich
HNRNPA2B1	P22626	170	204	202	353	Compositional bias	Note=Gly-rich
HNRNPA2B1	P22626	2	14	4	4	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPA2B1	P22626	51	100	85	85	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:24275569
HNRNPA2B1	P22626	170	204	173	173	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HNRNPA2B1	P22626	170	204	176	176	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPA2B1	P22626	170	204	189	189	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPA2B1	P22626	170	204	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPA2B1	P22626	170	204	203	203	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88569
HNRNPA2B1	P22626	170	204	203	203	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6
HNRNPA2B1	P22626	170	204	203	203	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:15782174,ECO:0000244|PubMed:24129315,ECO:0000269|Ref.6;Dbxref=PMID:15782174,PMID:24129315
HNRNPA2B1	P22626	204	231	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
HNRNPA2B1	P22626	204	231	213	213	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88569
HNRNPA2B1	P22626	204	231	213	213	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6
HNRNPA2B1	P22626	204	231	213	213	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.6;Dbxref=PMID:24129315
HNRNPA2B1	P22626	204	231	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
HNRNPA2B1	P22626	204	231	228	228	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA2B1	P22626	231	252	231	231	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569
HNRNPA2B1	P22626	204	231	231	231	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569
HNRNPA2B1	P22626	231	252	236	236	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
HNRNPA2B1	P22626	231	252	238	238	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA2B1	P22626	252	292	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17924679,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
HNRNPA2B1	P22626	252	292	266	266	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A7VJC2
HNRNPA2B1	P22626	252	292	266	266	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA2B1	P22626	292	333	324	324	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
HNRNPA2B1	P22626	292	333	325	325	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA2B1	P22626	292	333	331	331	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
HNRNPA2B1	P22626	170	204	173	173	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
HNRNPA2B1	P22626	170	204	186	186	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
HNRNPA2B1	P22626	2	14	3	14	Alternative sequence	ID=VSP_005830;Note=In isoform A2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2557628;Dbxref=PMID:2557628
HNRNPA2B1	P22626	292	333	302	302	Natural variant	ID=VAR_070591;Note=In IBMPFD2. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23455423;Dbxref=dbSNP:rs397515326,PMID:23455423
HNRNPA2B1	P22626	204	231	207	207	Mutagenesis	Note=Does not affect hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	204	231	209	209	Mutagenesis	Note=Does not affect hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	204	231	219	219	Mutagenesis	Note=Does not affect hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	204	231	227	227	Mutagenesis	Note=Does not affect hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	231	252	234	234	Mutagenesis	Note=Does not affect hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	231	252	240	240	Mutagenesis	Note=Does not affect hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	231	252	244	244	Mutagenesis	Note=Does not affect hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	231	252	247	247	Mutagenesis	Note=Slightly affects hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	256	256	Mutagenesis	Note=Does not affect hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	262	262	Mutagenesis	Note=Slightly affects hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	269	269	Mutagenesis	Note=Does not affect hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	276	276	Mutagenesis	Note=Impairs hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	283	283	Mutagenesis	Note=Slightly affects hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	287	287	Mutagenesis	Note=Does not affect hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	252	292	290	290	Mutagenesis	Note=Impairs hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	295	295	Mutagenesis	Note=Impairs hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	300	300	Mutagenesis	Note=Slightly affects hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	303	303	Mutagenesis	Note=Impairs hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	306	306	Mutagenesis	Note=Slightly affects hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	313	313	Mutagenesis	Note=Slightly affects hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	321	321	Mutagenesis	Note=Impairs hydrogel-binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	292	333	331	331	Mutagenesis	Note=Impairs hydrogel-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544936;Dbxref=PMID:26544936
HNRNPA2B1	P22626	204	231	205	205	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HNRNPA2B1	P22626	51	100	47	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	51	100	56	58	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	51	100	61	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	51	100	72	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	51	100	83	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X4B
HNRNPA2B1	P22626	51	100	92	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	51	100	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	170	204	174	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	170	204	180	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA2B1	P22626	170	204	190	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HO4
HNRNPA3	P51991	65	114	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	184	214	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	214	246	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	273	320	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	65	114	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	184	214	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	214	246	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	273	320	1	378	Chain	ID=PRO_0000081838;Note=Heterogeneous nuclear ribonucleoprotein A3
HNRNPA3	P51991	65	114	35	118	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA3	P51991	65	114	35	118	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA3	P51991	184	214	126	205	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA3	P51991	184	214	126	205	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
HNRNPA3	P51991	184	214	211	378	Compositional bias	Note=Gly-rich
HNRNPA3	P51991	214	246	211	378	Compositional bias	Note=Gly-rich
HNRNPA3	P51991	273	320	211	378	Compositional bias	Note=Gly-rich
HNRNPA3	P51991	184	214	211	378	Compositional bias	Note=Gly-rich
HNRNPA3	P51991	214	246	211	378	Compositional bias	Note=Gly-rich
HNRNPA3	P51991	273	320	211	378	Compositional bias	Note=Gly-rich
HNRNPA3	P51991	65	114	76	76	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	65	114	76	76	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	65	114	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPA3	P51991	65	114	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HNRNPA3	P51991	184	214	214	214	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	214	246	214	214	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	184	214	214	214	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	214	246	214	214	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	184	214	214	214	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	214	214	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	184	214	214	214	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	214	214	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	216	216	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	214	246	216	216	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	214	246	216	216	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	216	216	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	226	226	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BG05
HNRNPA3	P51991	214	246	226	226	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BG05
HNRNPA3	P51991	214	246	226	226	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	226	226	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	239	239	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	239	239	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	239	239	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BG05
HNRNPA3	P51991	214	246	239	239	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BG05
HNRNPA3	P51991	214	246	246	246	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.6;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	246	246	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24129315,ECO:0000269|Ref.6;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	246	246	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	214	246	246	246	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
HNRNPA3	P51991	273	320	286	286	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
HNRNPA3	P51991	273	320	286	286	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6URK4
ROGDI	Q9GZN7	144	177	2	287	Chain	ID=PRO_0000315664;Note=Protein rogdi homolog
ROGDI	Q9GZN7	144	177	140	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XQH
ROGDI	Q9GZN7	144	177	168	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XQH
ROGDI	Q9GZN7	144	177	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XQH
RPL13	P26373	140	159	1	211	Chain	ID=PRO_0000192919;Note=60S ribosomal protein L13
RPL13	P26373	140	159	1	211	Chain	ID=PRO_0000192919;Note=60S ribosomal protein L13
RPL13	P26373	140	159	1	211	Chain	ID=PRO_0000192919;Note=60S ribosomal protein L13
RPL13	P26373	140	159	145	145	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL13	P26373	140	159	145	145	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL13	P26373	140	159	145	145	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RHBDD3	Q9Y3P4	49	177	1	386	Chain	ID=PRO_0000079569;Note=Rhomboid domain-containing protein 3
RHBDD3	Q9Y3P4	49	177	58	78	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD3	Q9Y3P4	49	177	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD3	Q9Y3P4	49	177	141	161	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD3	Q9Y3P4	49	177	163	183	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RHBDD3	Q9Y3P4	49	177	86	86	Natural variant	ID=VAR_021952;Note=T->M;Dbxref=dbSNP:rs2272902
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	376	432	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	319	375	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	205	261	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	2	461	Chain	ID=PRO_0000097343;Note=Ribonuclease inhibitor
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	77	105	Repeat	Note=LRR 3
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	106	133	Repeat	Note=LRR 4
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	91	147	134	162	Repeat	Note=LRR 5
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	191	219	Repeat	Note=LRR 7
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	220	247	Repeat	Note=LRR 8
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	205	261	248	276	Repeat	Note=LRR 9
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	305	333	Repeat	Note=LRR 11
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	319	375	334	361	Repeat	Note=LRR 12
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	362	390	Repeat	Note=LRR 13
RNH1	P13489	319	375	362	390	Repeat	Note=LRR 13
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	391	418	Repeat	Note=LRR 14
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	376	432	419	447	Repeat	Note=LRR 15
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	91	147	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	319	375	319	319	Mutagenesis	Note=Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2%3B when associated with A-262 and A-264. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12578357;Dbxref=PMID:12578357
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	376	432	376	376	Mutagenesis	Note=40-fold reduction in binding affinity for RNASE2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15755456;Dbxref=PMID:15755456
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	359	359	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	319	375	365	365	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	376	432	423	424	Sequence conflict	Note=RQ->SE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	117	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	126	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	91	147	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	205	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	327	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	345	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	354	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	319	375	374	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	384	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	407	409	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	412	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RNH1	P13489	376	432	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z7X
RRM1	P23921	129	149	1	792	Chain	ID=PRO_0000187190;Note=Ribonucleoside-diphosphate reductase large subunit
RRM1	P23921	490	564	1	792	Chain	ID=PRO_0000187190;Note=Ribonucleoside-diphosphate reductase large subunit
RRM1	P23921	635	667	1	792	Chain	ID=PRO_0000187190;Note=Ribonucleoside-diphosphate reductase large subunit
RRM1	P23921	129	149	128	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	129	149	137	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	129	149	145	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	490	564	489	498	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	490	564	502	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	490	564	508	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	490	564	519	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HND
RRM1	P23921	490	564	522	550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	490	564	554	556	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNE
RRM1	P23921	490	564	561	563	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	635	667	632	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNC
RRM1	P23921	635	667	639	648	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	635	667	655	661	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WGH
RRM1	P23921	635	667	662	664	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HNC
RRM1	P23921	635	667	666	668	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AUI
PRPF4B	Q13523	471	522	2	1007	Chain	ID=PRO_0000086586;Note=Serine/threonine-protein kinase PRP4 homolog
PRPF4B	Q13523	471	522	39	496	Compositional bias	Note=Arg/Lys-rich (basic)
PRPF4B	Q13523	471	522	518	518	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692
PRPF4B	Q13523	471	522	519	519	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
PRPF4B	Q13523	471	522	520	520	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
PRPF8	Q6P2Q9	1546	1595	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	1341	1400	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	1100	1148	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	573	618	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	90	144	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	1546	1595	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	1341	1400	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	1100	1148	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	573	618	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	90	144	2	2335	Chain	ID=PRO_0000097040;Note=Pre-mRNA-processing-splicing factor 8
PRPF8	Q6P2Q9	1100	1148	812	1303	Region	Note=Reverse transcriptase homology domain
PRPF8	Q6P2Q9	1100	1148	812	1303	Region	Note=Reverse transcriptase homology domain
PRPF8	Q6P2Q9	1546	1595	1304	1577	Region	Note=Linker
PRPF8	Q6P2Q9	1341	1400	1304	1577	Region	Note=Linker
PRPF8	Q6P2Q9	1546	1595	1304	1577	Region	Note=Linker
PRPF8	Q6P2Q9	1341	1400	1304	1577	Region	Note=Linker
PRPF8	Q6P2Q9	1546	1595	1581	1752	Region	Note=Restriction endonuclease homology domain
PRPF8	Q6P2Q9	1546	1595	1581	1752	Region	Note=Restriction endonuclease homology domain
PRPF8	Q6P2Q9	1341	1400	1358	1358	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PRPF8	Q6P2Q9	1341	1400	1358	1358	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PRPF8	Q6P2Q9	573	618	604	604	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRPF8	Q6P2Q9	573	618	604	604	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRPF8	Q6P2Q9	1341	1400	1390	1390	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRPF8	Q6P2Q9	1341	1400	1390	1390	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUCB2	P80303	48	84	25	420	Chain	ID=PRO_0000004165;Note=Nucleobindin-2
NUCB2	P80303	304	334	25	420	Chain	ID=PRO_0000004165;Note=Nucleobindin-2
NUCB2	P80303	334	391	25	420	Chain	ID=PRO_0000004165;Note=Nucleobindin-2
NUCB2	P80303	48	84	25	106	Chain	ID=PRO_0000419819;Note=Nesfatin-1
NUCB2	P80303	304	334	293	328	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NUCB2	P80303	304	334	306	317	Calcium binding	Note=2
NUCB2	P80303	304	334	213	420	Region	Note=Binds to necdin;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUCB2	P80303	334	391	213	420	Region	Note=Binds to necdin;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUCB2	P80303	304	334	332	332	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NUCB2	P80303	334	391	338	338	Natural variant	ID=VAR_024399;Note=Q->E;Dbxref=dbSNP:rs757081
NUF2	Q9BZD4	269	316	1	464	Chain	ID=PRO_0000249813;Note=Kinetochore protein Nuf2
NUF2	Q9BZD4	269	316	1	464	Chain	ID=PRO_0000249813;Note=Kinetochore protein Nuf2
NUF2	Q9BZD4	269	316	1	385	Region	Note=Interaction with the N-terminus of NDC80
NUF2	Q9BZD4	269	316	1	385	Region	Note=Interaction with the N-terminus of NDC80
NUF2	Q9BZD4	269	316	147	345	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUF2	Q9BZD4	269	316	147	345	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NXF1	Q9UBU9	526	586	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	393	428	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	266	302	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	186	213	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	526	586	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	393	428	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	266	302	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	186	213	2	619	Chain	ID=PRO_0000220529;Note=Nuclear RNA export factor 1
NXF1	Q9UBU9	186	213	119	198	Domain	Note=RRM
NXF1	Q9UBU9	186	213	119	198	Domain	Note=RRM
NXF1	Q9UBU9	266	302	266	291	Repeat	Note=LRR 1
NXF1	Q9UBU9	266	302	266	291	Repeat	Note=LRR 1
NXF1	Q9UBU9	266	302	292	315	Repeat	Note=LRR 2
NXF1	Q9UBU9	266	302	292	315	Repeat	Note=LRR 2
NXF1	Q9UBU9	526	586	386	536	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NXF1	Q9UBU9	393	428	386	536	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NXF1	Q9UBU9	526	586	386	536	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NXF1	Q9UBU9	393	428	386	536	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
NXF1	Q9UBU9	526	586	565	619	Domain	Note=TAP-C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00611
NXF1	Q9UBU9	526	586	565	619	Domain	Note=TAP-C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00611
NXF1	Q9UBU9	186	213	2	198	Region	Note=Interaction with ALYREF/THOC4 and LUZP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25662211;Dbxref=PMID:25662211
NXF1	Q9UBU9	186	213	2	198	Region	Note=Interaction with ALYREF/THOC4 and LUZP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25662211;Dbxref=PMID:25662211
NXF1	Q9UBU9	526	586	551	561	Compositional bias	Note=Pro-rich
NXF1	Q9UBU9	526	586	551	561	Compositional bias	Note=Pro-rich
NXF1	Q9UBU9	526	586	357	619	Alternative sequence	ID=VSP_041428;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NXF1	Q9UBU9	393	428	357	619	Alternative sequence	ID=VSP_041428;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NXF1	Q9UBU9	526	586	357	619	Alternative sequence	ID=VSP_041428;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NXF1	Q9UBU9	393	428	357	619	Alternative sequence	ID=VSP_041428;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NXF1	Q9UBU9	393	428	399	399	Mutagenesis	Note=60%25 reduction in mRNA export activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11583626;Dbxref=PMID:11583626
NXF1	Q9UBU9	393	428	399	399	Mutagenesis	Note=60%25 reduction in mRNA export activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11583626;Dbxref=PMID:11583626
NXF1	Q9UBU9	186	213	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	186	213	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	186	213	198	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	186	213	198	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	186	213	206	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	186	213	206	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	269	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	269	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	281	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	281	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	286	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	286	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	295	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	266	302	295	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RW6
NXF1	Q9UBU9	393	428	381	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	393	428	381	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	393	428	403	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	393	428	403	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	393	428	410	419	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	393	428	410	419	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	526	586	525	538	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	526	586	525	538	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	526	586	541	548	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	526	586	541	548	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JKG
NXF1	Q9UBU9	526	586	553	557	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GO5
NXF1	Q9UBU9	526	586	553	557	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GO5
NXF1	Q9UBU9	526	586	565	578	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OAI
NXF1	Q9UBU9	526	586	565	578	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OAI
NXF1	Q9UBU9	526	586	582	591	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OAI
NXF1	Q9UBU9	526	586	582	591	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OAI
NXPE1	Q8N323	298	369	22	547	Chain	ID=PRO_0000307930;Note=NXPE family member 1
NXPE1	Q8N323	298	369	353	353	Natural variant	ID=VAR_036712;Note=G->R;Dbxref=dbSNP:rs10891692
NXPE3	Q969Y0	307	376	31	559	Chain	ID=PRO_0000297594;Note=NXPE family member 3
NXPE3	Q969Y0	307	376	31	559	Chain	ID=PRO_0000297594;Note=NXPE family member 3
NXPE3	Q969Y0	307	376	31	559	Chain	ID=PRO_0000297594;Note=NXPE family member 3
NXPE3	Q969Y0	307	376	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NXPE3	Q969Y0	307	376	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NXPE3	Q969Y0	307	376	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NXPE4	Q6UWF7	297	366	28	544	Chain	ID=PRO_0000019553;Note=NXPE family member 4
NUP107	P57740	243	267	1	925	Chain	ID=PRO_0000204831;Note=Nuclear pore complex protein Nup107
NUP107	P57740	417	437	1	925	Chain	ID=PRO_0000204831;Note=Nuclear pore complex protein Nup107
NUP107	P57740	565	578	1	925	Chain	ID=PRO_0000204831;Note=Nuclear pore complex protein Nup107
NUP107	P57740	796	834	1	925	Chain	ID=PRO_0000204831;Note=Nuclear pore complex protein Nup107
NUP107	P57740	796	834	831	831	Natural variant	ID=VAR_076359;Note=In NPHS11%3B decreased interaction with NUP133%3B changed localization to the nuclear pore with relocalization to the cytoplasm. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26411495;Dbxref=dbSNP:rs864321632,PMID:26411495
NUP107	P57740	796	834	782	821	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUP107	P57740	796	834	824	826	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUBP1	P53384	6	41	1	320	Chain	ID=PRO_0000184943;Note=Cytosolic Fe-S cluster assembly factor NUBP1
NUBP1	P53384	86	109	1	320	Chain	ID=PRO_0000184943;Note=Cytosolic Fe-S cluster assembly factor NUBP1
NUBP1	P53384	109	120	1	320	Chain	ID=PRO_0000184943;Note=Cytosolic Fe-S cluster assembly factor NUBP1
NUBP1	P53384	273	301	1	320	Chain	ID=PRO_0000184943;Note=Cytosolic Fe-S cluster assembly factor NUBP1
NUBP1	P53384	6	41	8	8	Metal binding	Note=Iron-sulfur 1 (4Fe-4S);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03038
NUBP1	P53384	6	41	22	22	Metal binding	Note=Iron-sulfur 1 (4Fe-4S);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03038
NUBP1	P53384	6	41	25	25	Metal binding	Note=Iron-sulfur 1 (4Fe-4S);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03038
NUBP1	P53384	6	41	31	31	Metal binding	Note=Iron-sulfur 1 (4Fe-4S);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03038
NUBP1	P53384	109	120	110	120	Alternative sequence	ID=VSP_029043;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NUBP1	P53384	6	41	39	39	Natural variant	ID=VAR_020359;Note=P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2233531,PMID:15489334
NUDT16	Q96DE0	46	136	1	195	Chain	ID=PRO_0000057117;Note=U8 snoRNA-decapping enzyme
NUDT16	Q96DE0	46	136	18	173	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT16	Q96DE0	46	136	61	82	Motif	Note=Nudix box
NUDT16	Q96DE0	46	136	59	59	Metal binding	Note=Magnesium or manganese 1%3B via carbonyl oxygen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121039;Dbxref=PMID:26121039
NUDT16	Q96DE0	46	136	76	76	Metal binding	Note=Magnesium or manganese 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121039;Dbxref=PMID:26121039
NUDT16	Q96DE0	46	136	76	76	Metal binding	Note=Magnesium or manganese 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6TEC1
NUDT16	Q96DE0	46	136	80	80	Metal binding	Note=Magnesium or manganese 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121039;Dbxref=PMID:26121039
NUDT16	Q96DE0	46	136	80	80	Metal binding	Note=Magnesium or manganese 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6TEC1
NUDT16	Q96DE0	46	136	136	136	Metal binding	Note=Magnesium or manganese 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6TEC1
NUDT16	Q96DE0	46	136	136	136	Metal binding	Note=Magnesium or manganese 4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6TEC1
NUDT16	Q96DE0	46	136	50	50	Binding site	Note=Substrate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26121039;Dbxref=PMID:26121039
NUDT16	Q96DE0	46	136	57	57	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26121039;Dbxref=PMID:26121039
NUDT16	Q96DE0	46	136	1	46	Alternative sequence	ID=VSP_045449;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16344560;Dbxref=PMID:16344560
NUDT16	Q96DE0	46	136	39	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	64	66	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MGM
NUDT16	Q96DE0	46	136	69	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	83	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	92	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	95	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	102	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	117	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
NUDT16	Q96DE0	46	136	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSQ
PSMC6	P62333	299	326	1	389	Chain	ID=PRO_0000084732;Note=26S proteasome regulatory subunit 10B
NUDT17	P0C025	134	165	1	328	Chain	ID=PRO_0000019953;Note=Nucleoside diphosphate-linked moiety X motif 17
NUDT17	P0C025	134	165	90	236	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT17	P0C025	134	165	127	148	Motif	Note=Nudix box
NUDT17	P0C025	134	165	142	142	Metal binding	Note=Magnesium or manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUDT17	P0C025	134	165	146	146	Metal binding	Note=Magnesium or manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUDT17	P0C025	134	165	135	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LF8
NUDT17	P0C025	134	165	155	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LF8
NUMA1	Q14980	1536	1550	1	2115	Chain	ID=PRO_0000057998;Note=Nuclear mitotic apparatus protein 1
NUMA1	Q14980	414	1536	1	2115	Chain	ID=PRO_0000057998;Note=Nuclear mitotic apparatus protein 1
NUMA1	Q14980	97	124	1	2115	Chain	ID=PRO_0000057998;Note=Nuclear mitotic apparatus protein 1
NUMA1	Q14980	97	124	1	212	Region	Note=Head (Globular)
NUMA1	Q14980	1536	1550	213	1699	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUMA1	Q14980	414	1536	213	1699	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
NUMA1	Q14980	414	1536	820	820	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
NUMA1	Q14980	414	1536	891	891	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NUMA1	Q14980	414	1536	1047	1047	Modified residue	Note=Phosphothreonine%3B by PLK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22327364;Dbxref=PMID:22327364
NUMA1	Q14980	414	1536	1187	1187	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NUMA1	Q14980	414	1536	1225	1225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:24275569
NUMA1	Q14980	414	1536	1511	1511	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NUMA1	Q14980	1536	1550	414	1549	Alternative sequence	ID=VSP_054146;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NUMA1	Q14980	414	1536	414	1549	Alternative sequence	ID=VSP_054146;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NUMA1	Q14980	1536	1550	1536	1549	Alternative sequence	ID=VSP_012910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1541636;Dbxref=PMID:1541636
NUMA1	Q14980	414	1536	1536	1549	Alternative sequence	ID=VSP_012910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1541636;Dbxref=PMID:1541636
NUMA1	Q14980	414	1536	794	794	Natural variant	ID=VAR_031680;Note=A->G;Dbxref=dbSNP:rs3750913
NUMA1	Q14980	414	1536	1153	1153	Natural variant	ID=VAR_031681;Note=E->D;Dbxref=dbSNP:rs34311364
NUMA1	Q14980	414	1536	772	772	Sequence conflict	Note=Q->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUMA1	Q14980	414	1536	815	816	Sequence conflict	Note=ER->DG;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUMA1	Q14980	414	1536	873	873	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUMBL	Q9Y6R0	133	180	1	609	Chain	ID=PRO_0000057999;Note=Numb-like protein
NUMBL	Q9Y6R0	133	180	74	223	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
NUMBL	Q9Y6R0	133	180	135	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F0W
NUMBL	Q9Y6R0	133	180	141	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F0W
NUMBL	Q9Y6R0	133	180	144	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F0W
NUMBL	Q9Y6R0	133	180	156	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F0W
NUMBL	Q9Y6R0	133	180	164	167	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F0W
NUMBL	Q9Y6R0	133	180	168	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F0W
NUDT8	Q8WV74	109	135	1	236	Chain	ID=PRO_0000019948;Note=Nucleoside diphosphate-linked moiety X motif 8
NUDT8	Q8WV74	109	135	25	172	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUP85	Q9BW27	199	244	1	656	Chain	ID=PRO_0000324187;Note=Nuclear pore complex protein Nup85
NUP85	Q9BW27	244	285	1	656	Chain	ID=PRO_0000324187;Note=Nuclear pore complex protein Nup85
NUP85	Q9BW27	285	329	1	656	Chain	ID=PRO_0000324187;Note=Nuclear pore complex protein Nup85
NUP85	Q9BW27	365	392	1	656	Chain	ID=PRO_0000324187;Note=Nuclear pore complex protein Nup85
NUP85	Q9BW27	589	623	1	656	Chain	ID=PRO_0000324187;Note=Nuclear pore complex protein Nup85
NUP85	Q9BW27	199	244	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
NUP85	Q9BW27	199	244	32	199	Alternative sequence	ID=VSP_056081;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUP85	Q9BW27	589	623	591	656	Alternative sequence	ID=VSP_056082;Note=In isoform 2. IFSAEQTYELMRCLEDLTSRRPVHGESDTEQLQDDDIETTKVEMLRLSLARNLARAIIREGSLEGS->KVAAAVVFFACQSLLELSCIAVADVRVSSFVVLPVRVYSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUP93	Q8N1F7	99	120	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	120	163	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	163	188	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	188	218	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	594	633	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	712	740	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	740	783	1	819	Chain	ID=PRO_0000124782;Note=Nuclear pore complex protein Nup93
NUP93	Q8N1F7	740	783	767	767	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP93	Q8N1F7	99	120	1	123	Alternative sequence	ID=VSP_043117;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUP93	Q8N1F7	120	163	1	123	Alternative sequence	ID=VSP_043117;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUP93	Q8N1F7	594	633	629	629	Natural variant	ID=VAR_076475;Note=In NPHS12%3B doesnt affect nuclear envelope localization%3B doesn't affect nuclear pore complex assembly%3B doesn't abrogate interaction with NUP205%3B abrogates SMAD4 interaction%3B abrogates IPO7 interaction%3B impairs SMAD4 protein import%3B impairs SMAD4 protein signal transduction into nucleus%3B. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26878725;Dbxref=dbSNP:rs757674160,PMID:26878725
FAM114A1	Q8IWE2	219	264	1	563	Chain	ID=PRO_0000274561;Note=Protein NOXP20
FAM114A1	Q8IWE2	512	530	1	563	Chain	ID=PRO_0000274561;Note=Protein NOXP20
FAM114A1	Q8IWE2	219	264	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SLC25A15	Q9Y619	105	150	1	301	Chain	ID=PRO_0000090650;Note=Mitochondrial ornithine transporter 1
SLC25A15	Q9Y619	105	150	110	130	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A15	Q9Y619	105	150	104	197	Repeat	Note=Solcar 2
SLC25A15	Q9Y619	105	150	113	113	Natural variant	ID=VAR_058951;Note=In HHH syndrome%3B exhibits very low transport activity despite normal insertion in the liposomal membrane. G->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16601889,ECO:0000269|PubMed:19242930;Dbxref=dbSNP:rs199894905,PMID:16601889,PMID:19242930
SLC25A15	Q9Y619	105	150	126	126	Natural variant	ID=VAR_012759;Note=In HHH syndrome. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11814739;Dbxref=PMID:11814739
NSG1	P42857	43	82	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	82	119	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	43	82	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	82	119	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	43	82	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	82	119	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	43	82	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	82	119	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	43	82	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	82	119	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	43	82	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	82	119	1	185	Chain	ID=PRO_0000164363;Note=Neuronal vesicle trafficking-associated protein 1
NSG1	P42857	43	82	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	43	82	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	43	82	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	43	82	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	43	82	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	43	82	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	1	82	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	83	103	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG1	P42857	82	119	83	103	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG1	P42857	82	119	83	103	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG1	P42857	82	119	83	103	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG1	P42857	82	119	83	103	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG1	P42857	82	119	83	103	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG1	P42857	82	119	104	185	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	104	185	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	104	185	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	104	185	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	104	185	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	82	119	104	185	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P02683
NSG1	P42857	43	82	43	81	Alternative sequence	ID=VSP_054333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSG1	P42857	43	82	43	81	Alternative sequence	ID=VSP_054333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSG1	P42857	43	82	43	81	Alternative sequence	ID=VSP_054333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSG1	P42857	43	82	43	81	Alternative sequence	ID=VSP_054333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSG1	P42857	43	82	43	81	Alternative sequence	ID=VSP_054333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSG1	P42857	43	82	43	81	Alternative sequence	ID=VSP_054333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF39	Q86UA1	190	245	1	669	Chain	ID=PRO_0000259648;Note=Pre-mRNA-processing factor 39
PRPF39	Q86UA1	301	337	1	669	Chain	ID=PRO_0000259648;Note=Pre-mRNA-processing factor 39
PRPF39	Q86UA1	190	245	183	218	Repeat	Note=HAT 3
PRPF39	Q86UA1	190	245	220	253	Repeat	Note=HAT 4
PRPF39	Q86UA1	301	337	333	365	Repeat	Note=HAT 5
PRPF39	Q86UA1	190	245	1	396	Alternative sequence	ID=VSP_021496;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF39	Q86UA1	301	337	1	396	Alternative sequence	ID=VSP_021496;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRPF39	Q86UA1	301	337	312	312	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRPF4	O43172	342	382	1	522	Chain	ID=PRO_0000051149;Note=U4/U6 small nuclear ribonucleoprotein Prp4
PRPF4	O43172	342	382	321	360	Repeat	Note=WD 3
PRPF4	O43172	342	382	363	402	Repeat	Note=WD 4
PRRC1	Q96M27	34	164	1	445	Chain	ID=PRO_0000307338;Note=Protein PRRC1
PRRC1	Q96M27	34	164	11	129	Compositional bias	Note=Pro-rich
PRRC1	Q96M27	34	164	70	70	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRRT4	C9JH25	252	292	24	899	Chain	ID=PRO_0000394498;Note=Proline-rich transmembrane protein 4
PRRT4	C9JH25	252	292	24	899	Chain	ID=PRO_0000394498;Note=Proline-rich transmembrane protein 4
NUDCD3	Q8IVD9	214	262	1	361	Chain	ID=PRO_0000057985;Note=NudC domain-containing protein 3
NUDCD3	Q8IVD9	214	262	185	277	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
NUDCD3	Q8IVD9	214	262	235	235	Natural variant	ID=VAR_031709;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11550029,PMID:15489334
NUDCD3	Q8IVD9	214	262	212	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NUDCD3	Q8IVD9	214	262	215	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NUDCD3	Q8IVD9	214	262	221	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NUDCD3	Q8IVD9	214	262	231	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NUDCD3	Q8IVD9	214	262	248	250	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NUDCD3	Q8IVD9	214	262	252	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NUDCD3	Q8IVD9	214	262	259	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGV
NCL	P19338	204	270	2	710	Chain	ID=PRO_0000081691;Note=Nucleolin
NCL	P19338	204	270	185	209	Compositional bias	Note=Asp/Glu-rich (acidic)
NCL	P19338	204	270	234	271	Compositional bias	Note=Asp/Glu-rich (acidic)
NCL	P19338	204	270	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17487921,PMID:18669648,PMID:23186163
NCL	P19338	204	270	214	214	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NUDT7	P0C024	63	116	1	238	Chain	ID=PRO_0000057140;Note=Peroxisomal coenzyme A diphosphatase NUDT7
NUDT7	P0C024	63	116	37	172	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT7	P0C024	63	116	77	98	Motif	Note=Nudix box
NUDT7	P0C024	63	116	92	92	Metal binding	Note=Magnesium or manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUDT7	P0C024	63	116	96	96	Metal binding	Note=Magnesium or manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUDT7	P0C024	63	116	64	116	Alternative sequence	ID=VSP_047605;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
NUDT7	P0C024	63	116	100	100	Natural variant	ID=VAR_050415;Note=R->H;Dbxref=dbSNP:rs308925
NUDT7	P0C024	63	116	64	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T3P
NUDT7	P0C024	63	116	74	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T3P
NUDT7	P0C024	63	116	85	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T3P
NUDT7	P0C024	63	116	101	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T3P
NUDT7	P0C024	63	116	104	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T3P
NUDT7	P0C024	63	116	113	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T3P
NUDT9	Q9BW91	116	147	47	350	Chain	ID=PRO_0000019950;Note=ADP-ribose pyrophosphatase%2C mitochondrial
NUDT9	Q9BW91	148	176	47	350	Chain	ID=PRO_0000019950;Note=ADP-ribose pyrophosphatase%2C mitochondrial
NUDT9	Q9BW91	116	147	121	121	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
NUDT9	Q9BW91	116	147	118	118	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDT9	Q9BW91	116	147	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q33
NUDT9	Q9BW91	148	176	155	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q33
NUDT9	Q9BW91	148	176	163	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q33
NUP54	Q7Z3B4	428	465	1	507	Chain	ID=PRO_0000204874;Note=Nucleoporin p54
NUP54	Q7Z3B4	352	388	1	507	Chain	ID=PRO_0000204874;Note=Nucleoporin p54
NUP54	Q7Z3B4	50	98	1	507	Chain	ID=PRO_0000204874;Note=Nucleoporin p54
NUP54	Q7Z3B4	50	98	53	54	Repeat	Note=4
NUP54	Q7Z3B4	50	98	61	62	Repeat	Note=5
NUP54	Q7Z3B4	50	98	63	64	Repeat	Note=6
NUP54	Q7Z3B4	50	98	67	68	Repeat	Note=7
NUP54	Q7Z3B4	50	98	87	88	Repeat	Note=8
NUP54	Q7Z3B4	428	465	444	445	Repeat	Note=9
NUP54	Q7Z3B4	428	465	5	445	Region	Note=9 X 2 AA repeats of F-G
NUP54	Q7Z3B4	352	388	5	445	Region	Note=9 X 2 AA repeats of F-G
NUP54	Q7Z3B4	50	98	5	445	Region	Note=9 X 2 AA repeats of F-G
NUP54	Q7Z3B4	50	98	6	89	Compositional bias	Note=Gly-rich
NUP54	Q7Z3B4	50	98	30	99	Compositional bias	Note=Thr-rich
NUP54	Q7Z3B4	50	98	93	97	Compositional bias	Note=Poly-Gln
NUP54	Q7Z3B4	50	98	1	180	Alternative sequence	ID=VSP_008740;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NUP54	Q7Z3B4	50	98	51	99	Alternative sequence	ID=VSP_054355;Note=In isoform 3. GLFGGTQNKGFGFGTGFGTTTGTSTGLGTGLGTGLGFGGFNTQQQQQTT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUP54	Q7Z3B4	352	388	353	388	Alternative sequence	ID=VSP_008741;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NUP54	Q7Z3B4	352	388	363	363	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP54	Q7Z3B4	428	465	433	433	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP54	Q7Z3B4	428	465	454	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JNU
NUP54	Q7Z3B4	428	465	457	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JNU
POFUT2	Q9Y2G5	176	212	22	429	Chain	ID=PRO_0000012154;Note=GDP-fucose protein O-fucosyltransferase 2
POFUT2	Q9Y2G5	176	212	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22588082;Dbxref=PMID:22588082
POFUT2	Q9Y2G5	176	212	209	209	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
POFUT2	Q9Y2G5	176	212	161	192	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22588082;Dbxref=PMID:22588082
POFUT2	Q9Y2G5	176	212	179	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AP5
POFUT2	Q9Y2G5	176	212	186	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AP5
POFUT2	Q9Y2G5	176	212	199	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AP5
POFUT2	Q9Y2G5	176	212	203	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AP5
NSG2	Q9Y328	71	108	1	171	Chain	ID=PRO_0000164366;Note=Neuronal vesicle trafficking-associated protein 2
NSG2	Q9Y328	71	108	1	71	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG2	Q9Y328	71	108	72	92	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSG2	Q9Y328	71	108	93	171	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NSRP1	Q9H0G5	38	57	1	558	Chain	ID=PRO_0000240434;Note=Nuclear speckle splicing regulatory protein 1
NSUN7	Q8NE18	345	393	1	718	Chain	ID=PRO_0000289238;Note=Putative methyltransferase NSUN7
NSUN7	Q8NE18	393	427	1	718	Chain	ID=PRO_0000289238;Note=Putative methyltransferase NSUN7
NSUN7	Q8NE18	345	393	278	718	Alternative sequence	ID=VSP_025977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NSUN7	Q8NE18	393	427	278	718	Alternative sequence	ID=VSP_025977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC40	O60508	329	363	1	579	Chain	ID=PRO_0000051142;Note=Pre-mRNA-processing factor 17
CDC40	O60508	329	363	1	579	Chain	ID=PRO_0000051142;Note=Pre-mRNA-processing factor 17
CDC40	O60508	329	363	330	369	Repeat	Note=WD 2
CDC40	O60508	329	363	330	369	Repeat	Note=WD 2
NUP43	Q8NFH3	81	107	1	380	Chain	ID=PRO_0000051111;Note=Nucleoporin Nup43
NUP43	Q8NFH3	81	107	72	110	Repeat	Note=WD 2
NUP43	Q8NFH3	81	107	77	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I79
NUP43	Q8NFH3	81	107	97	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I79
NUP43	Q8NFH3	81	107	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I79
OGFOD1	Q8N543	219	262	1	542	Chain	ID=PRO_0000288974;Note=Prolyl 3-hydroxylase OGFOD1
OGFOD1	Q8N543	262	300	1	542	Chain	ID=PRO_0000288974;Note=Prolyl 3-hydroxylase OGFOD1
OGFOD1	Q8N543	219	262	134	239	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
OGFOD1	Q8N543	219	262	230	230	Binding site	Note=2-oxoglutarate;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00805,ECO:0000305|PubMed:25728928;Dbxref=PMID:25728928
OGFOD1	Q8N543	219	262	218	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	219	262	230	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	266	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	272	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	277	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
POFUT1	Q9H488	82	143	27	388	Chain	ID=PRO_0000012148;Note=GDP-fucose protein O-fucosyltransferase 1
POFUT1	Q9H488	82	143	126	140	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5UX6,ECO:0000244|PDB:5UXH,ECO:0000269|PubMed:28334865;Dbxref=PMID:28334865
POFUT1	Q9H488	82	143	83	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	87	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	91	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UXH
POFUT1	Q9H488	82	143	94	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	105	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	113	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	119	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	123	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	128	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
POFUT1	Q9H488	82	143	142	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UX6
NSMCE1	Q8WV22	161	200	1	266	Chain	ID=PRO_0000270944;Note=Non-structural maintenance of chromosomes element 1 homolog
NSMCE1	Q8WV22	86	112	1	266	Chain	ID=PRO_0000270944;Note=Non-structural maintenance of chromosomes element 1 homolog
NSMCE1	Q8WV22	161	200	191	232	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
NSMCE1	Q8WV22	86	112	1	102	Region	Note=Interaction with NSMCE3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20864041;Dbxref=PMID:20864041
NSMCE1	Q8WV22	86	112	82	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	86	112	95	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	86	112	103	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	161	200	158	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	161	200	165	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	161	200	170	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	161	200	185	187	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	161	200	189	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HVQ
NSMCE1	Q8WV22	161	200	192	194	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY5
NSMCE1	Q8WV22	161	200	197	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HVQ
NTAN1	Q96AB6	144	162	1	310	Chain	ID=PRO_0000057971;Note=Protein N-terminal asparagine amidohydrolase
NTAN1	Q96AB6	61	83	1	310	Chain	ID=PRO_0000057971;Note=Protein N-terminal asparagine amidohydrolase
NTAN1	Q96AB6	61	83	75	75	Site	Note=Essential for catalytic activity
NTAN1	Q96AB6	61	83	75	75	Mutagenesis	Note=Abolishes catalytic activity. C->A%2CS%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21375249;Dbxref=PMID:21375249
WDYHV1	Q96HA8	61	78	1	205	Chain	ID=PRO_0000279409;Note=Protein N-terminal glutamine amidohydrolase
WDYHV1	Q96HA8	61	78	62	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C9Q
WDYHV1	Q96HA8	61	78	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C9Q
NTPCR	Q9BSD7	98	168	2	190	Chain	ID=PRO_0000146711;Note=Cancer-related nucleoside-triphosphatase
NTPCR	Q9BSD7	98	168	109	116	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
NTPCR	Q9BSD7	98	168	165	165	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NTPCR	Q9BSD7	98	168	106	106	Natural variant	ID=VAR_053071;Note=G->E;Dbxref=dbSNP:rs12123482
NTPCR	Q9BSD7	98	168	114	114	Mutagenesis	Note=Reduced activity%2C especially towards ATP%2C GTP and TTP. E->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17291528;Dbxref=PMID:17291528
NTPCR	Q9BSD7	98	168	116	116	Mutagenesis	Note=Reduced activity%2C especially towards ATP%2C GTP and TTP. G->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17291528;Dbxref=PMID:17291528
NTPCR	Q9BSD7	98	168	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I3B
NTPCR	Q9BSD7	98	168	117	121	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I3B
NTPCR	Q9BSD7	98	168	124	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I3B
NTPCR	Q9BSD7	98	168	140	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I3B
NTPCR	Q9BSD7	98	168	155	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I3B
NTPCR	Q9BSD7	98	168	164	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I3B
NTRK2	Q16620	284	386	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
NTRK2	Q16620	386	398	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
NTRK2	Q16620	284	386	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
NTRK2	Q16620	386	398	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
NTRK2	Q16620	284	386	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK2	Q16620	386	398	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK2	Q16620	284	386	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK2	Q16620	386	398	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK2	Q16620	284	386	295	365	Domain	Note=Ig-like C2-type 2
NTRK2	Q16620	284	386	295	365	Domain	Note=Ig-like C2-type 2
NTRK2	Q16620	284	386	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK2	Q16620	284	386	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NTRK2	Q16620	284	386	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7574684;Dbxref=PMID:7574684
NTRK2	Q16620	284	386	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7574684;Dbxref=PMID:7574684
NTRK2	Q16620	284	386	302	345	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:7574684;Dbxref=PMID:7574684
NTRK2	Q16620	284	386	302	345	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:7574684;Dbxref=PMID:7574684
NTRK2	Q16620	284	386	309	309	Natural variant	ID=VAR_016320;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5
NTRK2	Q16620	284	386	309	309	Natural variant	ID=VAR_016320;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5
NTRK2	Q16620	284	386	338	338	Natural variant	ID=VAR_011973;Note=N->Y;Dbxref=dbSNP:rs1047856
NTRK2	Q16620	284	386	338	338	Natural variant	ID=VAR_011973;Note=N->Y;Dbxref=dbSNP:rs1047856
NTRK2	Q16620	284	386	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MO9
NTRK2	Q16620	284	386	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MO9
NTRK2	Q16620	284	386	300	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	300	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	328	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	328	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	353	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	353	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWB
NTRK2	Q16620	284	386	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MO9
NTRK2	Q16620	284	386	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MO9
NUAK1	O60285	193	233	1	661	Chain	ID=PRO_0000086453;Note=NUAK family SNF1-like kinase 1
NUAK1	O60285	193	233	55	306	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NUAK1	O60285	193	233	211	211	Modified residue	Note=Phosphothreonine%3B by LKB1;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:14976552,ECO:0000269|PubMed:20354225;Dbxref=PMID:19369195,PMID:14976552,PMID:20354225
NUAK1	O60285	193	233	182	208	Alternative sequence	ID=VSP_014236;Note=In isoform 2. ENILLDDNCNIKIADFGLSNLYQKDKF->KKTSRENQVTTLPQSAVSLRSCWTVMM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUAK1	O60285	193	233	209	661	Alternative sequence	ID=VSP_014237;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NUAK1	O60285	193	233	211	211	Mutagenesis	Note=Prevents phosphorylation and activation by STK11/LKB1 complex. Abolishes ability to induce senescence. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14976552,ECO:0000269|PubMed:19927127,ECO:0000269|PubMed:21317932;Dbxref=PMID:14976552,PMID:19927127,PMID:21317932
NUDT12	Q9BQG2	265	321	1	462	Chain	ID=PRO_0000056956;Note=Peroxisomal NADH pyrophosphatase NUDT12
NUDT12	Q9BQG2	265	321	319	453	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT12	Q9BQG2	265	321	292	292	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCN1
PRSS33	Q8NF86	15	26	1	22	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
PRSS33	Q8NF86	15	26	23	280	Chain	ID=PRO_0000299316;Note=Serine protease 33
OPA1	O60313	149	185	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	185	203	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	226	244	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	244	279	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	373	398	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	920	957	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	149	185	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	208	226	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	226	261	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	355	380	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	902	939	88	960	Chain	ID=PRO_0000007397;Note=Dynamin-like 120 kDa protein%2C mitochondrial
OPA1	O60313	185	203	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	226	244	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	244	279	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	373	398	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	920	957	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	208	226	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	226	261	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	355	380	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	902	939	195	960	Chain	ID=PRO_0000253479;Note=Dynamin-like 120 kDa protein%2C form S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	149	185	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	185	203	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	226	244	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	244	279	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	373	398	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	920	957	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	149	185	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	208	226	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	226	261	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	355	380	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	902	939	114	960	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPA1	O60313	373	398	285	561	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
OPA1	O60313	355	380	285	561	Domain	Note=Dynamin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
OPA1	O60313	373	398	398	402	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	373	398	398	401	Region	Note=G3 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01055
OPA1	O60313	226	244	210	254	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	244	279	210	254	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	208	226	210	254	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	226	261	210	254	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	920	957	895	960	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	902	939	895	960	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
OPA1	O60313	185	203	194	195	Site	Note=Cleavage at site S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2TA68
OPA1	O60313	226	244	228	228	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
OPA1	O60313	226	261	228	228	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
OPA1	O60313	149	185	150	185	Alternative sequence	ID=VSP_059072;Note=In isoform 3 and isoform 7. Missing
OPA1	O60313	185	203	150	185	Alternative sequence	ID=VSP_059072;Note=In isoform 3 and isoform 7. Missing
OPA1	O60313	149	185	150	185	Alternative sequence	ID=VSP_059072;Note=In isoform 3 and isoform 7. Missing
OPA1	O60313	185	203	186	186	Alternative sequence	ID=VSP_059073;Note=In isoform 4 and isoform 5. G->GHKLVSEVIGASDLLLLLG
OPA1	O60313	208	226	209	209	Alternative sequence	ID=VSP_021035;Note=In isoform 2. V->GLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKV;Ontology_term=ECO:0000305;evidence=ECO:0000305
OPA1	O60313	149	185	158	158	Natural variant	ID=VAR_022924;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11440988,ECO:0000269|PubMed:11440989,ECO:0000269|PubMed:12036970,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15948788,ECO:0000269|PubMed:16617242,ECO:0000269|PubMed:9628581;Dbxref=dbSNP:rs7624750,PMID:11440988,PMID:11440989,PMID:12036970,PMID:15489334,PMID:15948788,PMID:16617242,PMID:9628581
OPA1	O60313	149	185	158	158	Natural variant	ID=VAR_022924;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11440988,ECO:0000269|PubMed:11440989,ECO:0000269|PubMed:12036970,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15948788,ECO:0000269|PubMed:16617242,ECO:0000269|PubMed:9628581;Dbxref=dbSNP:rs7624750,PMID:11440988,PMID:11440989,PMID:12036970,PMID:15489334,PMID:15948788,PMID:16617242,PMID:9628581
OPA1	O60313	149	185	167	167	Natural variant	ID=VAR_022925;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12036970;Dbxref=PMID:12036970
OPA1	O60313	149	185	167	167	Natural variant	ID=VAR_022925;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12036970;Dbxref=PMID:12036970
OPA1	O60313	185	203	192	192	Natural variant	ID=VAR_022926;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11440988,ECO:0000269|PubMed:12036970,ECO:0000269|PubMed:16617242;Dbxref=dbSNP:rs34307082,PMID:11440988,PMID:12036970,PMID:16617242
OPA1	O60313	244	279	270	270	Natural variant	ID=VAR_060829;Note=In OPA1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11440988;Dbxref=PMID:11440988
OPA1	O60313	244	279	272	272	Natural variant	ID=VAR_060830;Note=In OPA1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14961560;Dbxref=PMID:14961560
OPA1	O60313	244	279	273	273	Natural variant	ID=VAR_060831;Note=In OPA1. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11440988;Dbxref=PMID:11440988
OPA1	O60313	355	380	357	357	Natural variant	ID=VAR_060836;Note=In DOA+ and OPA1. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18158317,ECO:0000269|PubMed:19319978;Dbxref=dbSNP:rs190223702,PMID:18158317,PMID:19319978
OPA1	O60313	373	398	377	377	Natural variant	ID=VAR_072126;Note=In OPA1. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23401657;Dbxref=dbSNP:rs780922750,PMID:23401657
OPA1	O60313	355	380	377	377	Natural variant	ID=VAR_072126;Note=In OPA1. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23401657;Dbxref=dbSNP:rs780922750,PMID:23401657
OPA1	O60313	373	398	382	382	Natural variant	ID=VAR_060837;Note=In OPA1 and BEHRS. I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19319978,ECO:0000269|PubMed:21636302,ECO:0000269|PubMed:25146916;Dbxref=dbSNP:rs143319805,PMID:19319978,PMID:21636302,PMID:25146916
OPA1	O60313	373	398	384	384	Natural variant	ID=VAR_060838;Note=In OPA1. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11440989;Dbxref=PMID:11440989
OPA1	O60313	373	398	396	396	Natural variant	ID=VAR_060839;Note=In OPA1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19319978;Dbxref=PMID:19319978
OPA1	O60313	373	398	396	396	Natural variant	ID=VAR_022927;Note=In OPA1. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12036970;Dbxref=dbSNP:rs727504060,PMID:12036970
OPA1	O60313	902	939	907	907	Natural variant	ID=VAR_060867;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11440989;Dbxref=dbSNP:rs863224138,PMID:11440989
OPA1	O60313	902	939	910	910	Natural variant	ID=VAR_072132;Note=In DOA+%3B impairs protein folding%3B loss of function in promoting mitochondrial fusion. V->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18158317,ECO:0000269|PubMed:20185555;Dbxref=dbSNP:rs387906901,PMID:18158317,PMID:20185555
OPA1	O60313	902	939	910	910	Natural variant	ID=VAR_072133;Note=In OPA1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22857269;Dbxref=PMID:22857269
OPA1	O60313	920	957	932	932	Natural variant	ID=VAR_060868;Note=In OPA1. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19319978,ECO:0000269|PubMed:19325939;Dbxref=dbSNP:rs145710079,PMID:19319978,PMID:19325939
OPA1	O60313	902	939	932	932	Natural variant	ID=VAR_060868;Note=In OPA1. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19319978,ECO:0000269|PubMed:19325939;Dbxref=dbSNP:rs145710079,PMID:19319978,PMID:19325939
OPA1	O60313	920	957	939	939	Natural variant	ID=VAR_028370;Note=In OPA1%3B impairs protein folding%3B loss of function in promoting mitochondrial fusion. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11810270,ECO:0000269|PubMed:20185555;Dbxref=PMID:11810270,PMID:20185555
OPA1	O60313	902	939	939	939	Natural variant	ID=VAR_028370;Note=In OPA1%3B impairs protein folding%3B loss of function in promoting mitochondrial fusion. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11810270,ECO:0000269|PubMed:20185555;Dbxref=PMID:11810270,PMID:20185555
OPA1	O60313	920	957	949	949	Natural variant	ID=VAR_060869;Note=In OPA1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19319978,ECO:0000269|PubMed:19969356;Dbxref=PMID:19319978,PMID:19969356
ORC2	Q13416	236	269	1	577	Chain	ID=PRO_0000127075;Note=Origin recognition complex subunit 2
ORC2	Q13416	109	140	1	577	Chain	ID=PRO_0000127075;Note=Origin recognition complex subunit 2
ORC2	Q13416	79	109	1	577	Chain	ID=PRO_0000127075;Note=Origin recognition complex subunit 2
ORC2	Q13416	79	109	1	100	Repeat	Note=Involved in LRWD1-binding
ORC2	Q13416	109	140	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
ORC2	Q13416	109	140	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ORC2	Q13416	109	140	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ORC2	Q13416	236	269	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ORC2	Q13416	79	109	106	106	Natural variant	ID=VAR_014515;Note=M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs2307361
ORC2	Q13416	109	140	131	131	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ORC2	Q13416	236	269	236	236	Sequence conflict	Note=T->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAFAH1B3	Q15102	95	136	2	231	Chain	ID=PRO_0000058155;Note=Platelet-activating factor acetylhydrolase IB subunit gamma
PAFAH1B3	Q15102	56	95	2	231	Chain	ID=PRO_0000058155;Note=Platelet-activating factor acetylhydrolase IB subunit gamma
PAFAH1B3	Q15102	95	136	2	231	Chain	ID=PRO_0000058155;Note=Platelet-activating factor acetylhydrolase IB subunit gamma
PAFAH1B3	Q15102	56	95	2	231	Chain	ID=PRO_0000058155;Note=Platelet-activating factor acetylhydrolase IB subunit gamma
PAFAH1B3	Q15102	26	56	2	231	Chain	ID=PRO_0000058155;Note=Platelet-activating factor acetylhydrolase IB subunit gamma
PAFAH1B3	Q15102	26	56	47	47	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q29460
NDUFA7	O95182	34	83	2	113	Chain	ID=PRO_0000118834;Note=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
NDUFA7	O95182	34	83	40	40	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1P6
NDUFA7	O95182	34	83	66	66	Natural variant	ID=VAR_050589;Note=P->A;Dbxref=dbSNP:rs2288415
NDUFA7	O95182	34	83	54	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA7	O95182	34	83	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
MFSD2A	Q8NA29	322	350	1	543	Chain	ID=PRO_0000273387;Note=Sodium-dependent lysophosphatidylcholine symporter 1
MFSD2A	Q8NA29	350	378	1	543	Chain	ID=PRO_0000273387;Note=Sodium-dependent lysophosphatidylcholine symporter 1
MFSD2A	Q8NA29	322	350	311	331	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2A	Q8NA29	322	350	332	344	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2A	Q8NA29	322	350	345	365	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2A	Q8NA29	350	378	345	365	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2A	Q8NA29	350	378	366	370	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2A	Q8NA29	350	378	371	391	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MFSD2A	Q8NA29	350	378	352	352	Natural variant	ID=VAR_074626;Note=In MCPH15%3B properly expressed at the plasma membrane%3B decreased LPC transport activity. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26005865;Dbxref=dbSNP:rs1057519087,PMID:26005865
NIPA2	Q8N8Q9	46	65	1	360	Chain	ID=PRO_0000191743;Note=Magnesium transporter NIPA2
NIPA2	Q8N8Q9	46	65	1	360	Chain	ID=PRO_0000191743;Note=Magnesium transporter NIPA2
NIPA2	Q8N8Q9	46	65	1	360	Chain	ID=PRO_0000191743;Note=Magnesium transporter NIPA2
NIPA2	Q8N8Q9	46	65	31	56	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPA2	Q8N8Q9	46	65	31	56	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPA2	Q8N8Q9	46	65	31	56	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPA2	Q8N8Q9	46	65	57	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPA2	Q8N8Q9	46	65	57	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPA2	Q8N8Q9	46	65	57	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NIPA2	Q8N8Q9	46	65	47	66	Alternative sequence	ID=VSP_044587;Note=In isoform 2. GQGGHAYLKEWLWWAGLLSM->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NIPA2	Q8N8Q9	46	65	47	66	Alternative sequence	ID=VSP_044587;Note=In isoform 2. GQGGHAYLKEWLWWAGLLSM->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NIPA2	Q8N8Q9	46	65	47	66	Alternative sequence	ID=VSP_044587;Note=In isoform 2. GQGGHAYLKEWLWWAGLLSM->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NKAIN1	Q4KMZ8	64	91	22	207	Chain	ID=PRO_0000412169;Note=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
NKAIN1	Q4KMZ8	64	91	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKAIN1	Q4KMZ8	64	91	83	146	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NKAIN1	Q4KMZ8	64	91	65	91	Alternative sequence	ID=VSP_056114;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NKAIN1	Q4KMZ8	64	91	88	88	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NMI	Q13287	27	59	1	307	Chain	ID=PRO_0000159702;Note=N-myc-interactor
NMI	Q13287	27	59	41	41	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PMS1	P54277	44	105	1	932	Chain	ID=PRO_0000178004;Note=PMS1 protein homolog 1
PMS1	P54277	194	233	1	932	Chain	ID=PRO_0000178004;Note=PMS1 protein homolog 1
PMS1	P54277	233	274	1	932	Chain	ID=PRO_0000178004;Note=PMS1 protein homolog 1
PMS1	P54277	619	780	1	932	Chain	ID=PRO_0000178004;Note=PMS1 protein homolog 1
PMS1	P54277	619	780	571	639	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
PMS1	P54277	44	105	1	176	Alternative sequence	ID=VSP_047692;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS1	P54277	194	233	195	233	Alternative sequence	ID=VSP_043371;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS1	P54277	233	274	195	233	Alternative sequence	ID=VSP_043371;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS1	P54277	619	780	619	619	Alternative sequence	ID=VSP_042676;Note=In isoform 2 and isoform 4. K->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS1	P54277	619	780	620	781	Alternative sequence	ID=VSP_042677;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PMS1	P54277	194	233	202	202	Natural variant	ID=VAR_014877;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2066459
PMS1	P54277	619	780	632	632	Natural variant	ID=VAR_014878;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2066456
PMS1	P54277	619	780	720	720	Natural variant	ID=VAR_014879;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2066455
PMS1	P54277	619	780	614	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CS1
PMS1	P54277	619	780	626	628	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CS1
PMS1	P54277	619	780	629	638	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CS1
NOMO2	Q5JPE7	1148	1179	32	1267	Chain	ID=PRO_0000021820;Note=Nodal modulator 2
NOMO2	Q5JPE7	1108	1148	32	1267	Chain	ID=PRO_0000021820;Note=Nodal modulator 2
NOMO2	Q5JPE7	653	684	32	1267	Chain	ID=PRO_0000021820;Note=Nodal modulator 2
NOMO2	Q5JPE7	245	291	32	1267	Chain	ID=PRO_0000021820;Note=Nodal modulator 2
NOMO2	Q5JPE7	1148	1179	32	1155	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO2	Q5JPE7	1108	1148	32	1155	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO2	Q5JPE7	653	684	32	1155	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO2	Q5JPE7	245	291	32	1155	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO2	Q5JPE7	1148	1179	1156	1176	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NOMO2	Q5JPE7	1148	1179	1177	1267	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPHS1	O60500	1055	1095	23	1241	Chain	ID=PRO_0000015052;Note=Nephrin
NPHS1	O60500	1036	1055	23	1241	Chain	ID=PRO_0000015052;Note=Nephrin
NPHS1	O60500	1055	1095	23	1055	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPHS1	O60500	1036	1055	23	1055	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPHS1	O60500	1055	1095	1056	1076	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPHS1	O60500	1055	1095	1077	1241	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPHS1	O60500	1036	1055	943	1038	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NPHS1	O60500	1055	1095	1056	1095	Alternative sequence	ID=VSP_002598;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10550324;Dbxref=PMID:10550324
NPHS1	O60500	1055	1095	1077	1077	Natural variant	ID=VAR_013054;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11317351,ECO:0000269|PubMed:26560236,ECO:0000269|PubMed:9915943;Dbxref=dbSNP:rs4806213,PMID:11317351,PMID:26560236,PMID:9915943
NR1H2	P55055	14	60	1	460	Chain	ID=PRO_0000053532;Note=Oxysterols receptor LXR-beta
NR1H2	P55055	60	157	1	460	Chain	ID=PRO_0000053532;Note=Oxysterols receptor LXR-beta
NR1H2	P55055	14	60	1	460	Chain	ID=PRO_0000053532;Note=Oxysterols receptor LXR-beta
NR1H2	P55055	60	157	1	460	Chain	ID=PRO_0000053532;Note=Oxysterols receptor LXR-beta
NR1H2	P55055	60	157	84	161	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H2	P55055	60	157	84	161	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H2	P55055	60	157	87	107	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H2	P55055	60	157	87	107	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H2	P55055	60	157	125	149	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H2	P55055	60	157	125	149	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
NR1H2	P55055	14	60	1	85	Region	Note=Transactivation AF-1%3B required for ligand-independent transactivation function;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H2	P55055	60	157	1	85	Region	Note=Transactivation AF-1%3B required for ligand-independent transactivation function;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H2	P55055	14	60	1	85	Region	Note=Transactivation AF-1%3B required for ligand-independent transactivation function;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H2	P55055	60	157	1	85	Region	Note=Transactivation AF-1%3B required for ligand-independent transactivation function;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25661920;Dbxref=PMID:25661920
NR1H2	P55055	60	157	61	158	Alternative sequence	ID=VSP_053789;Note=In isoform 2. VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQC->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NR1H2	P55055	60	157	61	158	Alternative sequence	ID=VSP_053789;Note=In isoform 2. VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQC->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NR1H2	P55055	60	157	88	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	88	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	99	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	105	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	105	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	142	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NR1H2	P55055	60	157	142	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQA
NRCAM	Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	402	450	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	402	450	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
NRCAM	Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	402	450	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	402	450	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	402	450	361	448	Domain	Note=Ig-like 4
NRCAM	Q92823	402	450	361	448	Domain	Note=Ig-like 4
NRCAM	Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NRCAM	Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NRCAM	Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NRCAM	Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NRCAM	Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NRCAM	Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
NRCAM	Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	402	450	433	433	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	402	450	433	433	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRCAM	Q92823	402	450	382	432	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NRCAM	Q92823	402	450	382	432	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
NRCAM	Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
NRCAM	Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
NRCAM	Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NRCAM	Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
NRCAM	Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
NRCAM	Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
NRCAM	Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
NRCAM	Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
NRCAM	Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
NRCAM	Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
NRCAM	Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NRCAM	Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NRCAM	Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NRCAM	Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NRCAM	Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NRCAM	Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NRCAM	Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NRCAM	Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
NRCAM	Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NRCAM	Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NMRK1	Q9NWW6	106	129	1	199	Chain	ID=PRO_0000215891;Note=Nicotinamide riboside kinase 1
NMRK1	Q9NWW6	106	129	128	128	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2P0E,ECO:0000269|PubMed:17914902;Dbxref=PMID:17914902
NMRK1	Q9NWW6	106	129	129	129	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2P0E,ECO:0000244|PDB:2QL6,ECO:0000244|PDB:2QT0,ECO:0000244|PDB:2QT1,ECO:0000269|PubMed:17914902;Dbxref=PMID:17914902
NMRK1	Q9NWW6	106	129	106	130	Alternative sequence	ID=VSP_012676;Note=In isoform 2. KPLDTIWNRSYFLTIPYEECKRRRS->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NMRK1	Q9NWW6	106	129	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT1
NMRK1	Q9NWW6	106	129	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT1
NMRK1	Q9NWW6	106	129	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT1
NMRK1	Q9NWW6	106	129	122	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT1
NUP153	P49790	1300	1391	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	1181	1300	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	821	886	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	573	615	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	511	544	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	356	405	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	338	356	2	1475	Chain	ID=PRO_0000204842;Note=Nuclear pore complex protein Nup153
NUP153	P49790	821	886	793	822	Zinc finger	Note=RanBP2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00322
NUP153	P49790	821	886	851	880	Zinc finger	Note=RanBP2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00322
NUP153	P49790	821	886	857	857	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBR
NUP153	P49790	821	886	860	860	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBR
NUP153	P49790	821	886	871	871	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBR
NUP153	P49790	821	886	874	874	Metal binding	Note=Zinc 4;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBR
NUP153	P49790	338	356	338	338	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17081983,PMID:18220336,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
NUP153	P49790	338	356	343	343	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NUP153	P49790	356	405	369	369	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NUP153	P49790	356	405	384	384	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NUP153	P49790	356	405	388	388	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP153	P49790	511	544	516	516	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
NUP153	P49790	511	544	518	518	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NUP153	P49790	511	544	522	522	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
NUP153	P49790	511	544	529	529	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NUP153	P49790	573	615	588	588	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
NUP153	P49790	573	615	607	607	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NUP153	P49790	573	615	614	614	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
NUP153	P49790	511	544	534	534	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20068230;Dbxref=PMID:20068230
NUP153	P49790	511	544	544	544	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20068230;Dbxref=PMID:20068230
NUP153	P49790	338	356	353	353	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:28112733
NUP153	P49790	573	615	574	615	Alternative sequence	ID=VSP_054265;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NUP153	P49790	356	405	381	381	Natural variant	ID=VAR_070841;Note=V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857419,PMID:15489334
NUP153	P49790	356	405	402	402	Natural variant	ID=VAR_046556;Note=N->K;Dbxref=dbSNP:rs6906499
NUP153	P49790	821	886	821	821	Natural variant	ID=VAR_046557;Note=P->L;Dbxref=dbSNP:rs6905654
NUP153	P49790	821	886	827	827	Natural variant	ID=VAR_046558;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2274136,PMID:14702039
NUP153	P49790	1300	1391	1388	1388	Natural variant	ID=VAR_046559;Note=T->A;Dbxref=dbSNP:rs2228379
NUP153	P49790	821	886	836	836	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP153	P49790	821	886	858	860	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBR
NUP153	P49790	821	886	872	874	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EBR
NRXN2	Q9P2S2	206	236	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	1252	1282	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	384	399	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	259	283	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	249	259	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	1252	1282	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	384	399	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	259	283	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	249	259	29	1712	Chain	ID=PRO_0000019495;Note=Neurexin-2
NRXN2	Q9P2S2	206	236	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	1252	1282	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	384	399	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	259	283	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	249	259	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	1252	1282	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	384	399	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	259	283	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	249	259	29	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NRXN2	Q9P2S2	206	236	29	206	Domain	Note=Laminin G-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
NRXN2	Q9P2S2	206	236	202	242	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
NRXN2	Q9P2S2	384	399	289	486	Domain	Note=Laminin G-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
NRXN2	Q9P2S2	384	399	289	486	Domain	Note=Laminin G-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
NRXN2	Q9P2S2	1252	1282	1137	1345	Domain	Note=Laminin G-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
NRXN2	Q9P2S2	1252	1282	1137	1345	Domain	Note=Laminin G-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
NRXN2	Q9P2S2	206	236	206	219	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NRXN2	Q9P2S2	206	236	213	229	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NRXN2	Q9P2S2	206	236	231	241	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
NRXN2	Q9P2S2	259	283	260	283	Alternative sequence	ID=VSP_003505;Note=In isoform 2a. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:15489334
NRXN2	Q9P2S2	259	283	260	283	Alternative sequence	ID=VSP_003505;Note=In isoform 2a. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:15489334
NRXN2	Q9P2S2	384	399	393	399	Alternative sequence	ID=VSP_003506;Note=In isoform 2a. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:15489334
NRXN2	Q9P2S2	384	399	393	399	Alternative sequence	ID=VSP_003506;Note=In isoform 2a. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:15489334
NRXN2	Q9P2S2	1252	1282	1253	1282	Alternative sequence	ID=VSP_003508;Note=In isoform 2a. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:15489334
NRXN2	Q9P2S2	1252	1282	1253	1282	Alternative sequence	ID=VSP_003508;Note=In isoform 2a. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:15489334;Dbxref=PMID:10231032,PMID:15489334
NT5DC4	Q86YG4	181	198	1	428	Chain	ID=PRO_0000344218;Note=5'-nucleotidase domain-containing protein 4
NT5DC4	Q86YG4	237	273	1	428	Chain	ID=PRO_0000344218;Note=5'-nucleotidase domain-containing protein 4
NT5DC4	Q86YG4	295	352	1	428	Chain	ID=PRO_0000344218;Note=5'-nucleotidase domain-containing protein 4
NT5DC4	Q86YG4	295	352	317	317	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUP133	Q8WUM0	1033	1060	1	1156	Chain	ID=PRO_0000204838;Note=Nuclear pore complex protein Nup133
NUP133	Q8WUM0	895	948	1	1156	Chain	ID=PRO_0000204838;Note=Nuclear pore complex protein Nup133
NUP133	Q8WUM0	692	733	1	1156	Chain	ID=PRO_0000204838;Note=Nuclear pore complex protein Nup133
NUP133	Q8WUM0	216	273	1	1156	Chain	ID=PRO_0000204838;Note=Nuclear pore complex protein Nup133
NUP133	Q8WUM0	895	948	928	928	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUP133	Q8WUM0	216	273	216	218	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XKS
NUP133	Q8WUM0	216	273	219	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XKS
NUP133	Q8WUM0	216	273	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XKS
NUP133	Q8WUM0	216	273	240	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XKS
NUP133	Q8WUM0	895	948	936	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUP133	Q8WUM0	895	948	946	959	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUP133	Q8WUM0	1033	1060	1028	1034	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUP133	Q8WUM0	1033	1060	1045	1051	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUP133	Q8WUM0	1033	1060	1052	1057	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CQC
NUCB1	Q02818	45	81	27	461	Chain	ID=PRO_0000004162;Note=Nucleobindin-1
NUCB1	Q02818	272	303	27	461	Chain	ID=PRO_0000004162;Note=Nucleobindin-1
NUCB1	Q02818	45	81	27	461	Chain	ID=PRO_0000004162;Note=Nucleobindin-1
NUCB1	Q02818	272	303	27	461	Chain	ID=PRO_0000004162;Note=Nucleobindin-1
NUCB1	Q02818	272	303	240	275	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NUCB1	Q02818	272	303	240	275	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NUCB1	Q02818	272	303	292	327	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NUCB1	Q02818	272	303	292	327	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
NUCB1	Q02818	45	81	42	51	Region	Note=O-glycosylated at one site
NUCB1	Q02818	45	81	42	51	Region	Note=O-glycosylated at one site
NUCB1	Q02818	272	303	228	321	Region	Note=Binds to GNAI2 and GNAI3;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUCB1	Q02818	272	303	228	321	Region	Note=Binds to GNAI2 and GNAI3;Ontology_term=ECO:0000250;evidence=ECO:0000250
NUCB1	Q02818	272	303	299	300	Sequence conflict	Note=HV->QL;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUCB1	Q02818	272	303	299	300	Sequence conflict	Note=HV->QL;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUCB1	Q02818	272	303	262	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SNL
NUCB1	Q02818	272	303	262	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SNL
NUCB1	Q02818	272	303	285	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SNL
NUCB1	Q02818	272	303	285	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SNL
NUCB1	Q02818	272	303	291	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SNL
NUCB1	Q02818	272	303	291	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SNL
NUDT5	Q9UKK9	165	183	1	219	Chain	ID=PRO_0000057048;Note=ADP-sugar pyrophosphatase
NUDT5	Q9UKK9	96	128	1	219	Chain	ID=PRO_0000057048;Note=ADP-sugar pyrophosphatase
NUDT5	Q9UKK9	165	183	1	219	Chain	ID=PRO_0000057048;Note=ADP-sugar pyrophosphatase
NUDT5	Q9UKK9	96	128	1	219	Chain	ID=PRO_0000057048;Note=ADP-sugar pyrophosphatase
NUDT5	Q9UKK9	165	183	57	197	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT5	Q9UKK9	96	128	57	197	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT5	Q9UKK9	165	183	57	197	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT5	Q9UKK9	96	128	57	197	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT5	Q9UKK9	96	128	97	118	Motif	Note=Nudix box
NUDT5	Q9UKK9	96	128	97	118	Motif	Note=Nudix box
NUDT5	Q9UKK9	96	128	96	96	Metal binding	Note=Magnesium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	96	96	Metal binding	Note=Magnesium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	112	112	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	112	112	Metal binding	Note=Magnesium 2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	112	112	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	112	112	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	116	116	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	116	116	Metal binding	Note=Magnesium 1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	116	116	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	116	116	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	165	183	166	166	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	165	183	166	166	Metal binding	Note=Magnesium 3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17052728,ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:21768126;Dbxref=PMID:17052728,PMID:18462755,PMID:21768126
NUDT5	Q9UKK9	96	128	98	98	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17052728;Dbxref=PMID:17052728
NUDT5	Q9UKK9	96	128	98	98	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17052728;Dbxref=PMID:17052728
NUDT5	Q9UKK9	96	128	123	123	Natural variant	ID=VAR_034159;Note=I->T;Dbxref=dbSNP:rs34863826
NUDT5	Q9UKK9	96	128	123	123	Natural variant	ID=VAR_034159;Note=I->T;Dbxref=dbSNP:rs34863826
NUDT5	Q9UKK9	96	128	98	98	Mutagenesis	Note=Reduces affinity for substrate about 6-fold. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18462755;Dbxref=PMID:18462755
NUDT5	Q9UKK9	96	128	98	98	Mutagenesis	Note=Reduces affinity for substrate about 6-fold. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18462755;Dbxref=PMID:18462755
NUDT5	Q9UKK9	96	128	112	112	Mutagenesis	Note=Catalytic inactive mutant for both ADP-sugar pyrophosphatase and nuclear ATP-synthesis activities. Reduces catalytic rate 6300-fold. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:27257257;Dbxref=PMID:18462755,PMID:27257257
NUDT5	Q9UKK9	96	128	112	112	Mutagenesis	Note=Catalytic inactive mutant for both ADP-sugar pyrophosphatase and nuclear ATP-synthesis activities. Reduces catalytic rate 6300-fold. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18462755,ECO:0000269|PubMed:27257257;Dbxref=PMID:18462755,PMID:27257257
NUDT5	Q9UKK9	96	128	116	116	Mutagenesis	Note=Reduces catalytic rate 2000-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18462755;Dbxref=PMID:18462755
NUDT5	Q9UKK9	96	128	116	116	Mutagenesis	Note=Reduces catalytic rate 2000-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18462755;Dbxref=PMID:18462755
NUDT5	Q9UKK9	165	183	166	166	Mutagenesis	Note=Reduces catalytic rate 120-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18462755;Dbxref=PMID:18462755
NUDT5	Q9UKK9	165	183	166	166	Mutagenesis	Note=Reduces catalytic rate 120-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18462755;Dbxref=PMID:18462755
NUDT5	Q9UKK9	96	128	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	96	128	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	96	128	105	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	96	128	105	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	96	128	122	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	96	128	122	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	165	183	164	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AC9
NUDT5	Q9UKK9	165	183	164	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AC9
NUDT5	Q9UKK9	165	183	169	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	165	183	169	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	165	183	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	165	183	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	165	183	178	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
NUDT5	Q9UKK9	165	183	178	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DSC
OSCAR	Q8IYS5	12	23	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
OSCAR	Q8IYS5	12	23	19	282	Chain	ID=PRO_0000310951;Note=Osteoclast-associated immunoglobulin-like receptor
OSCAR	Q8IYS5	12	23	22	116	Domain	Note=Ig-like 1
OSCAR	Q8IYS5	12	23	13	25	Alternative sequence	ID=VSP_029352;Note=In isoform 4 and isoform 6. WPLCHTDITPSVP->FP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11805147;Dbxref=PMID:11805147
OTUD4	Q01804	81	98	1	1114	Chain	ID=PRO_0000083979;Note=OTU domain-containing protein 4
OTUD4	Q01804	53	81	1	1114	Chain	ID=PRO_0000083979;Note=OTU domain-containing protein 4
OTUD4	Q01804	81	98	34	155	Domain	Note=OTU;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00139,ECO:0000269|PubMed:29395066;Dbxref=PMID:29395066
OTUD4	Q01804	53	81	34	155	Domain	Note=OTU;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00139,ECO:0000269|PubMed:29395066;Dbxref=PMID:29395066
OTUD4	Q01804	81	98	94	104	Region	Note=Variable-loop;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5VVQ6
OTUD4	Q01804	53	81	1	65	Alternative sequence	ID=VSP_038830;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1475186,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:1475186,PMID:15489334
NUP210L	Q5VU65	1232	1285	36	1888	Chain	ID=PRO_0000236048;Note=Nuclear pore membrane glycoprotein 210-like
NUP210L	Q5VU65	1080	1101	36	1888	Chain	ID=PRO_0000236048;Note=Nuclear pore membrane glycoprotein 210-like
NUP210L	Q5VU65	916	950	36	1888	Chain	ID=PRO_0000236048;Note=Nuclear pore membrane glycoprotein 210-like
NUP210L	Q5VU65	1080	1101	1082	1154	Domain	Note=BIG2;Ontology_term=ECO:0000255;evidence=ECO:0000255
NUP210L	Q5VU65	916	950	931	931	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PI4K2B	Q8TCG2	404	424	1	481	Chain	ID=PRO_0000285164;Note=Phosphatidylinositol 4-kinase type 2-beta
PI4K2B	Q8TCG2	404	424	129	436	Domain	Note=PI3K/PI4K
PI4K2B	Q8TCG2	404	424	411	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WTV
MRPL3	P09001	123	156	41	348	Chain	ID=PRO_0000077253;Note=39S ribosomal protein L3%2C mitochondrial
MRPL3	P09001	123	156	116	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	126	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	135	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	140	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	154	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL1	Q9BYD6	134	162	51	325	Chain	ID=PRO_0000252440;Note=39S ribosomal protein L1%2C mitochondrial
MRPL1	Q9BYD6	162	186	51	325	Chain	ID=PRO_0000252440;Note=39S ribosomal protein L1%2C mitochondrial
MRPL1	Q9BYD6	162	186	177	177	Natural variant	ID=VAR_027866;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855456,PMID:15489334
RNF157	Q96PX1	566	588	2	679	Chain	ID=PRO_0000261614;Note=E3 ubiquitin ligase RNF157
RNF157	Q96PX1	566	588	568	589	Alternative sequence	ID=VSP_021735;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF180	Q86T96	0	45	1	592	Chain	ID=PRO_0000261617;Note=E3 ubiquitin-protein ligase RNF180
RNF180	Q86T96	77	397	1	592	Chain	ID=PRO_0000261617;Note=E3 ubiquitin-protein ligase RNF180
RNF180	Q86T96	397	409	1	592	Chain	ID=PRO_0000261617;Note=E3 ubiquitin-protein ligase RNF180
RNF180	Q86T96	0	45	1	564	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF180	Q86T96	77	397	1	564	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF180	Q86T96	397	409	1	564	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF180	Q86T96	77	397	281	489	Region	Note=Interaction with ZIC2;Ontology_term=ECO:0000250;evidence=ECO:0000250
RNF180	Q86T96	397	409	281	489	Region	Note=Interaction with ZIC2;Ontology_term=ECO:0000250;evidence=ECO:0000250
RNF180	Q86T96	77	397	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3U827
RNF180	Q86T96	77	397	78	397	Alternative sequence	ID=VSP_021738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RNF180	Q86T96	397	409	78	397	Alternative sequence	ID=VSP_021738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RNF180	Q86T96	0	45	15	15	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF180	Q86T96	0	45	18	22	Sequence conflict	Note=SILRC->GETVFSL;Ontology_term=ECO:0000305;evidence=ECO:0000305
RANBP3L	Q86VV4	89	113	1	465	Chain	ID=PRO_0000312749;Note=Ran-binding protein 3-like
RANBP3L	Q86VV4	89	113	89	89	Alternative sequence	ID=VSP_044463;Note=In isoform 3. G->GVSTLSQKQMRCSSVTNLPTFPHSGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RANBP3L	Q86VV4	89	113	111	111	Natural variant	ID=VAR_037558;Note=A->D;Dbxref=dbSNP:rs35433829
RNF10	Q8N5U6	376	418	1	811	Chain	ID=PRO_0000259585;Note=RING finger protein 10
RNF10	Q8N5U6	594	628	1	811	Chain	ID=PRO_0000259585;Note=RING finger protein 10
RNF10	Q8N5U6	628	680	1	811	Chain	ID=PRO_0000259585;Note=RING finger protein 10
RNF10	Q8N5U6	733	786	1	811	Chain	ID=PRO_0000259585;Note=RING finger protein 10
RNF10	Q8N5U6	376	418	418	418	Alternative sequence	ID=VSP_021478;Note=In isoform 2. K->KSLLQQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
RPL4	P36578	278	305	2	427	Chain	ID=PRO_0000129350;Note=60S ribosomal protein L4
RPL4	P36578	278	305	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P50878
RPL4	P36578	278	305	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:20068231,PMID:23186163
RPL4	P36578	278	305	300	300	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL6	Q02878	79	112	2	288	Chain	ID=PRO_0000171009;Note=60S ribosomal protein L6
RPL6	Q02878	79	112	2	288	Chain	ID=PRO_0000171009;Note=60S ribosomal protein L6
RPL6	Q02878	79	112	94	94	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47911
RPL6	Q02878	79	112	94	94	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47911
RPL6	Q02878	79	112	100	100	Natural variant	ID=VAR_036437;Note=In a colorectal cancer sample%3B somatic mutation. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
RPL6	Q02878	79	112	100	100	Natural variant	ID=VAR_036437;Note=In a colorectal cancer sample%3B somatic mutation. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
MRPL39	Q9NYK5	307	323	1	338	Chain	ID=PRO_0000087684;Note=39S ribosomal protein L39%2C mitochondrial
MRPL39	Q9NYK5	307	323	310	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
UBOX5	O94941	418	472	1	541	Chain	ID=PRO_0000056076;Note=RING finger protein 37
UBOX5	O94941	418	472	451	451	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
UBOX5	O94941	418	472	419	472	Alternative sequence	ID=VSP_042899;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
MST1R	Q04912	1021	1090	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
MST1R	Q04912	987	1021	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
MST1R	Q04912	883	932	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
MST1R	Q04912	728	781	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
MST1R	Q04912	473	516	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
MST1R	Q04912	1021	1090	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	987	1021	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	883	932	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	728	781	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	473	516	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	883	932	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	728	781	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	473	516	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	1021	1090	979	1400	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	987	1021	979	1400	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	473	516	31	522	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
MST1R	Q04912	728	781	684	767	Domain	Note=IPT/TIG 2
MST1R	Q04912	728	781	770	860	Domain	Note=IPT/TIG 3
MST1R	Q04912	1021	1090	1082	1345	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MST1R	Q04912	1021	1090	1088	1096	Nucleotide binding	Note=ATP
MST1R	Q04912	473	516	488	488	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22848655;Dbxref=PMID:22848655
MST1R	Q04912	883	932	897	897	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MST1R	Q04912	473	516	411	516	Alternative sequence	ID=VSP_038919;Note=In isoform RON-2 and isoform RON-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	473	516	475	495	Alternative sequence	ID=VSP_038920;Note=In isoform RON-1. ELVRSLNYLLYVSNFSLGDSG->GPHPHSPLALGPCLHPHFAHI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	1021	1090	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	987	1021	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	883	932	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	728	781	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	473	516	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	1021	1090	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	987	1021	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	883	932	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	728	781	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	883	932	884	932	Alternative sequence	ID=VSP_005007;Note=In isoform Delta-RON. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MST1R	Q04912	883	932	884	907	Alternative sequence	ID=VSP_038924;Note=In isoform RON-3. YIGLGAVADCVGINVTVGGESCQH->VSVRDRGRDSWGSESRGQPTGWSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	1021	1090	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	987	1021	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	883	932	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
MST1R	Q04912	473	516	504	504	Natural variant	ID=VAR_041773;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34350470,PMID:17344846
MST1R	Q04912	883	932	900	900	Natural variant	ID=VAR_041776;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56091918,PMID:17344846
MST1R	Q04912	473	516	469	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FWW
MST1R	Q04912	473	516	485	491	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FWW
MST1R	Q04912	473	516	503	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FWW
MST1R	Q04912	473	516	508	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FWW
MST1R	Q04912	473	516	516	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FWW
MST1R	Q04912	1021	1090	1064	1069	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PLS
MST1R	Q04912	1021	1090	1071	1073	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PLS
MST1R	Q04912	1021	1090	1077	1079	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PLS
MST1R	Q04912	1021	1090	1080	1091	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PLS
RPAP1	Q9BWH6	914	965	1	1393	Chain	ID=PRO_0000284841;Note=RNA polymerase II-associated protein 1
RPAP1	Q9BWH6	692	744	1	1393	Chain	ID=PRO_0000284841;Note=RNA polymerase II-associated protein 1
RPAP1	Q9BWH6	386	420	1	1393	Chain	ID=PRO_0000284841;Note=RNA polymerase II-associated protein 1
RPAP1	Q9BWH6	353	386	1	1393	Chain	ID=PRO_0000284841;Note=RNA polymerase II-associated protein 1
RPAP1	Q9BWH6	254	314	1	1393	Chain	ID=PRO_0000284841;Note=RNA polymerase II-associated protein 1
RPAP1	Q9BWH6	180	254	1	1393	Chain	ID=PRO_0000284841;Note=RNA polymerase II-associated protein 1
RPAP1	Q9BWH6	914	965	827	1286	Compositional bias	Note=Leu-rich
RPAP1	Q9BWH6	386	420	1	621	Alternative sequence	ID=VSP_024679;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPAP1	Q9BWH6	353	386	1	621	Alternative sequence	ID=VSP_024679;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPAP1	Q9BWH6	254	314	1	621	Alternative sequence	ID=VSP_024679;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPAP1	Q9BWH6	180	254	1	621	Alternative sequence	ID=VSP_024679;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MRPL46	Q9H2W6	138	196	140	142	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL46	Q9H2W6	138	196	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J7Y
MRPL46	Q9H2W6	138	196	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL46	Q9H2W6	138	196	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL46	Q9H2W6	138	196	165	167	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J7Y
MRPL46	Q9H2W6	138	196	169	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL46	Q9H2W6	138	196	175	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL46	Q9H2W6	138	196	184	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	182	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	188	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	194	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	206	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
RNF138	Q8WVD3	131	149	2	245	Chain	ID=PRO_0000261607;Note=E3 ubiquitin-protein ligase RNF138
RNF138	Q8WVD3	187	223	2	245	Chain	ID=PRO_0000261607;Note=E3 ubiquitin-protein ligase RNF138
RNF138	Q8WVD3	187	223	187	215	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF138	Q8WVD3	131	149	142	142	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RNF138	Q8WVD3	131	149	38	131	Alternative sequence	ID=VSP_021732;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF138	Q8WVD3	187	223	215	215	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF165	Q6ZSG1	240	272	1	346	Chain	ID=PRO_0000245587;Note=E3 ubiquitin-protein ligase RNF165
RNF165	Q6ZSG1	240	272	266	268	Region	Note=Ubiquitin binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5D0K,ECO:0000269|PubMed:26656854;Dbxref=PMID:26656854
RNF165	Q6ZSG1	240	272	261	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D0I
RNF165	Q6ZSG1	240	272	265	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D0I
RNF112	Q9ULX5	127	196	1	631	Chain	ID=PRO_0000056301;Note=RING finger protein 112
RNF112	Q9ULX5	240	275	1	631	Chain	ID=PRO_0000056301;Note=RING finger protein 112
RNF112	Q9ULX5	127	196	166	397	Domain	Note=GB1/RHD3-type G
RNF112	Q9ULX5	240	275	166	397	Domain	Note=GB1/RHD3-type G
RNF112	Q9ULX5	127	196	131	631	Region	Note=Interaction with ZBTB16;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96DY5
RNF112	Q9ULX5	240	275	131	631	Region	Note=Interaction with ZBTB16;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96DY5
RNF167	Q9H6Y7	28	55	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	55	97	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	223	250	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	28	55	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	55	97	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	223	250	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	28	55	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	55	97	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	223	250	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	28	55	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	55	97	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	223	250	25	350	Chain	ID=PRO_0000245593;Note=E3 ubiquitin-protein ligase RNF167
RNF167	Q9H6Y7	28	55	49	152	Domain	Note=PA
RNF167	Q9H6Y7	55	97	49	152	Domain	Note=PA
RNF167	Q9H6Y7	28	55	49	152	Domain	Note=PA
RNF167	Q9H6Y7	55	97	49	152	Domain	Note=PA
RNF167	Q9H6Y7	28	55	49	152	Domain	Note=PA
RNF167	Q9H6Y7	55	97	49	152	Domain	Note=PA
RNF167	Q9H6Y7	28	55	49	152	Domain	Note=PA
RNF167	Q9H6Y7	55	97	49	152	Domain	Note=PA
RNF167	Q9H6Y7	223	250	230	272	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF167	Q9H6Y7	223	250	230	272	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF167	Q9H6Y7	223	250	230	272	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF167	Q9H6Y7	223	250	230	272	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF167	Q9H6Y7	55	97	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF167	Q9H6Y7	55	97	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF167	Q9H6Y7	55	97	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF167	Q9H6Y7	55	97	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF167	Q9H6Y7	223	250	232	232	Mutagenesis	Note=Drastically increased stability%3B reduction in auto-ubiquitination activity%3B loss of cell delay/arrest in G1. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16314844;Dbxref=PMID:16314844
RNF167	Q9H6Y7	223	250	232	232	Mutagenesis	Note=Drastically increased stability%3B reduction in auto-ubiquitination activity%3B loss of cell delay/arrest in G1. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16314844;Dbxref=PMID:16314844
RNF167	Q9H6Y7	223	250	232	232	Mutagenesis	Note=Drastically increased stability%3B reduction in auto-ubiquitination activity%3B loss of cell delay/arrest in G1. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16314844;Dbxref=PMID:16314844
RNF167	Q9H6Y7	223	250	232	232	Mutagenesis	Note=Drastically increased stability%3B reduction in auto-ubiquitination activity%3B loss of cell delay/arrest in G1. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16314844;Dbxref=PMID:16314844
RNF167	Q9H6Y7	223	250	224	224	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF167	Q9H6Y7	223	250	224	224	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF167	Q9H6Y7	223	250	224	224	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF167	Q9H6Y7	223	250	224	224	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF175	Q8N4F7	255	288	1	328	Chain	ID=PRO_0000245599;Note=RING finger protein 175
RNF175	Q8N4F7	255	288	227	277	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF175	Q8N4F7	255	288	256	309	Alternative sequence	ID=VSP_055435;Note=In isoform 2. FHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQILDWLRYLVA->YPFQRKLFGLHQASFFPPSPPPPPVPISSILLTFHAQTPVLYPPAQSSLPVCPC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DROSHA	Q9NRR4	585	614	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	529	556	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	316	352	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	285	315	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	585	614	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	529	556	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	316	352	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	285	315	1	1374	Chain	ID=PRO_0000180468;Note=Ribonuclease 3
DROSHA	Q9NRR4	585	614	390	1365	Region	Note=Necessary for interaction with DGCR8 and pri-miRNA processing activity;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26027739,ECO:0000269|PubMed:26748718;Dbxref=PMID:26027739,PMID:26748718
DROSHA	Q9NRR4	529	556	390	1365	Region	Note=Necessary for interaction with DGCR8 and pri-miRNA processing activity;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26027739,ECO:0000269|PubMed:26748718;Dbxref=PMID:26027739,PMID:26748718
DROSHA	Q9NRR4	585	614	390	1365	Region	Note=Necessary for interaction with DGCR8 and pri-miRNA processing activity;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26027739,ECO:0000269|PubMed:26748718;Dbxref=PMID:26027739,PMID:26748718
DROSHA	Q9NRR4	529	556	390	1365	Region	Note=Necessary for interaction with DGCR8 and pri-miRNA processing activity;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26027739,ECO:0000269|PubMed:26748718;Dbxref=PMID:26027739,PMID:26748718
DROSHA	Q9NRR4	316	352	219	316	Compositional bias	Note=Arg-rich
DROSHA	Q9NRR4	285	315	219	316	Compositional bias	Note=Arg-rich
DROSHA	Q9NRR4	316	352	219	316	Compositional bias	Note=Arg-rich
DROSHA	Q9NRR4	285	315	219	316	Compositional bias	Note=Arg-rich
DROSHA	Q9NRR4	529	556	536	536	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	536	536	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	538	538	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	538	538	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	549	549	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	549	549	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	585	614	609	609	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	585	614	609	609	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	316	352	285	353	Alternative sequence	ID=VSP_005777;Note=In isoform 2. RERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNH->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10976766;Dbxref=PMID:10976766
DROSHA	Q9NRR4	285	315	285	353	Alternative sequence	ID=VSP_005777;Note=In isoform 2. RERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNH->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10976766;Dbxref=PMID:10976766
DROSHA	Q9NRR4	316	352	285	353	Alternative sequence	ID=VSP_005777;Note=In isoform 2. RERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNH->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10976766;Dbxref=PMID:10976766
DROSHA	Q9NRR4	285	315	285	353	Alternative sequence	ID=VSP_005777;Note=In isoform 2. RERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNH->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10976766;Dbxref=PMID:10976766
DROSHA	Q9NRR4	316	352	316	352	Alternative sequence	ID=VSP_012450;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
DROSHA	Q9NRR4	316	352	316	352	Alternative sequence	ID=VSP_012450;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
DROSHA	Q9NRR4	316	352	321	321	Natural variant	ID=VAR_061778;Note=S->L;Dbxref=dbSNP:rs55656741
DROSHA	Q9NRR4	316	352	321	321	Natural variant	ID=VAR_061778;Note=S->L;Dbxref=dbSNP:rs55656741
DROSHA	Q9NRR4	529	556	536	536	Mutagenesis	Note=Impairs protein folding and stability%3B when associated with A-538. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	536	536	Mutagenesis	Note=Impairs protein folding and stability%3B when associated with A-538. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	538	538	Mutagenesis	Note=Impairs protein folding and stability%3B when associated with A-536. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	529	556	538	538	Mutagenesis	Note=Impairs protein folding and stability%3B when associated with A-536. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26748718;Dbxref=PMID:26748718
DROSHA	Q9NRR4	585	614	612	612	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DROSHA	Q9NRR4	585	614	612	612	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DROSHA	Q9NRR4	529	556	531	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	529	556	531	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	529	556	547	550	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	529	556	547	550	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	585	614	591	593	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	585	614	591	593	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	585	614	595	610	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
DROSHA	Q9NRR4	585	614	595	610	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B16
RNF32	Q9H0A6	228	284	1	362	Chain	ID=PRO_0000245532;Note=RING finger protein 32
RNF32	Q9H0A6	228	284	1	362	Chain	ID=PRO_0000245532;Note=RING finger protein 32
RNF32	Q9H0A6	228	284	1	362	Chain	ID=PRO_0000245532;Note=RING finger protein 32
RNF32	Q9H0A6	228	284	1	362	Chain	ID=PRO_0000245532;Note=RING finger protein 32
RNF32	Q9H0A6	228	284	96	362	Alternative sequence	ID=VSP_019739;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11890671;Dbxref=PMID:11890671
RNF32	Q9H0A6	228	284	96	362	Alternative sequence	ID=VSP_019739;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11890671;Dbxref=PMID:11890671
RNF32	Q9H0A6	228	284	96	362	Alternative sequence	ID=VSP_019739;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11890671;Dbxref=PMID:11890671
RNF32	Q9H0A6	228	284	96	362	Alternative sequence	ID=VSP_019739;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11890671;Dbxref=PMID:11890671
RNF32	Q9H0A6	228	284	170	352	Alternative sequence	ID=VSP_019741;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
RNF32	Q9H0A6	228	284	170	352	Alternative sequence	ID=VSP_019741;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
RNF32	Q9H0A6	228	284	170	352	Alternative sequence	ID=VSP_019741;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
RNF32	Q9H0A6	228	284	170	352	Alternative sequence	ID=VSP_019741;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
RNF32	Q9H0A6	228	284	229	235	Alternative sequence	ID=VSP_019743;Note=In isoform 3. FTEISHR->TQDWKPA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	229	235	Alternative sequence	ID=VSP_019743;Note=In isoform 3. FTEISHR->TQDWKPA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	229	235	Alternative sequence	ID=VSP_019743;Note=In isoform 3. FTEISHR->TQDWKPA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	229	235	Alternative sequence	ID=VSP_019743;Note=In isoform 3. FTEISHR->TQDWKPA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	236	362	Alternative sequence	ID=VSP_019744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	236	362	Alternative sequence	ID=VSP_019744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	236	362	Alternative sequence	ID=VSP_019744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
RNF32	Q9H0A6	228	284	236	362	Alternative sequence	ID=VSP_019744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
ELAC2	Q9BQ52	328	359	17	826	Chain	ID=PRO_0000155828;Note=Zinc phosphodiesterase ELAC protein 2
ELAC2	Q9BQ52	186	226	17	826	Chain	ID=PRO_0000155828;Note=Zinc phosphodiesterase ELAC protein 2
ELAC2	Q9BQ52	186	226	199	199	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ELAC2	Q9BQ52	186	226	208	208	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ELAC2	Q9BQ52	186	226	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ELAC2	Q9BQ52	328	359	1	372	Alternative sequence	ID=VSP_009168;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELAC2	Q9BQ52	186	226	1	372	Alternative sequence	ID=VSP_009168;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELAC2	Q9BQ52	186	226	188	227	Alternative sequence	ID=VSP_043449;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELAC2	Q9BQ52	186	226	211	211	Natural variant	ID=VAR_017425;Note=In HPC2. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11522646;Dbxref=dbSNP:rs148419785,PMID:11522646
ELAC2	Q9BQ52	186	226	217	217	Natural variant	ID=VAR_017426;Note=In HPC2%3B does not affect the enzymatic activity. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10986046,ECO:0000269|PubMed:11175785,ECO:0000269|PubMed:11522646,ECO:0000269|PubMed:12515253,ECO:0000269|PubMed:12522685,ECO:0000269|PubMed:12711671,ECO:0000269|PubMed:12783937,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:18987736,ECO:0000269|Ref.3;Dbxref=dbSNP:rs4792311,PMID:10986046,PMID:11175785,PMID:11522646,PMID:12515253,PMID:12522685,PMID:12711671,PMID:12783937,PMID:15489334,PMID:18987736
TRIM21	P19474	168	245	1	475	Chain	ID=PRO_0000056115;Note=E3 ubiquitin-protein ligase TRIM21
TRIM21	P19474	168	245	128	238	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM21	P19474	168	245	169	245	Alternative sequence	ID=VSP_039627;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIM21	P19474	168	245	231	231	Natural variant	ID=VAR_013751;Note=E->K;Dbxref=dbSNP:rs2554934
TRIM21	P19474	168	245	189	189	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIM21	P19474	168	245	216	216	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ROCK2	O75116	154	241	1	1388	Chain	ID=PRO_0000086625;Note=Rho-associated protein kinase 2
ROCK2	O75116	108	154	1	1388	Chain	ID=PRO_0000086625;Note=Rho-associated protein kinase 2
ROCK2	O75116	154	241	92	354	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK2	O75116	108	154	92	354	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK2	O75116	154	241	214	214	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
ROCK2	O75116	108	154	121	121	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK2	O75116	108	154	102	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	112	114	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	117	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	125	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	138	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	155	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	162	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	177	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	188	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	217	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	220	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	228	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	241	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
RORC	P51449	391	428	1	518	Chain	ID=PRO_0000053517;Note=Nuclear receptor ROR-gamma
RORC	P51449	355	391	1	518	Chain	ID=PRO_0000053517;Note=Nuclear receptor ROR-gamma
RORC	P51449	391	428	269	508	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
RORC	P51449	355	391	269	508	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
RORC	P51449	355	391	378	378	Mutagenesis	Note=Completely abolishes transcriptional activity. F->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20203100;Dbxref=PMID:20203100
RORC	P51449	391	428	397	397	Mutagenesis	Note=Nearly abolishes transcriptional activity. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20203100;Dbxref=PMID:20203100
RORC	P51449	355	391	346	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	355	391	365	368	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	355	391	371	374	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	355	391	375	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	355	391	381	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	391	428	385	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	355	391	385	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	391	428	394	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	391	428	409	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
RORC	P51449	391	428	414	425	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5APH
POLR3F	Q9H1D9	143	191	2	316	Chain	ID=PRO_0000073972;Note=DNA-directed RNA polymerase III subunit RPC6
POLR3F	Q9H1D9	227	291	2	316	Chain	ID=PRO_0000073972;Note=DNA-directed RNA polymerase III subunit RPC6
POLR3F	Q9H1D9	143	191	173	175	Mutagenesis	Note=Strongly impaired dsDNA-binding. No effect on interaction with POLR3C. ESE->KSK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358628;Dbxref=PMID:21358628
POLR3F	Q9H1D9	227	291	255	290	Sequence conflict	Note=AKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLC->CKRRHSWQCRWTHETVQGSQSNHPSHRFGPGHPVDSA;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLR3F	Q9H1D9	143	191	149	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DK5
POLR3GL	Q9BT43	85	108	1	218	Chain	ID=PRO_0000311590;Note=DNA-directed RNA polymerase III subunit RPC7-like
RMDN3	Q96TC7	375	408	1	470	Chain	ID=PRO_0000287510;Note=Regulator of microtubule dynamics protein 3
RMDN3	Q96TC7	127	174	1	470	Chain	ID=PRO_0000287510;Note=Regulator of microtubule dynamics protein 3
RMDN3	Q96TC7	375	408	1	470	Chain	ID=PRO_0000287510;Note=Regulator of microtubule dynamics protein 3
RMDN3	Q96TC7	127	174	1	470	Chain	ID=PRO_0000287510;Note=Regulator of microtubule dynamics protein 3
RMDN3	Q96TC7	127	174	1	129	Alternative sequence	ID=VSP_025531;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RMDN3	Q96TC7	127	174	1	129	Alternative sequence	ID=VSP_025531;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF8	O76064	325	346	1	485	Chain	ID=PRO_0000056048;Note=E3 ubiquitin-protein ligase RNF8
RNF8	O76064	346	376	1	485	Chain	ID=PRO_0000056048;Note=E3 ubiquitin-protein ligase RNF8
RNF8	O76064	376	412	1	485	Chain	ID=PRO_0000056048;Note=E3 ubiquitin-protein ligase RNF8
RNF8	O76064	376	412	403	441	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03067
RNF8	O76064	325	346	276	345	Compositional bias	Note=Gln-rich
RNF8	O76064	325	346	99	485	Alternative sequence	ID=VSP_037831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF8	O76064	346	376	99	485	Alternative sequence	ID=VSP_037831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF8	O76064	376	412	99	485	Alternative sequence	ID=VSP_037831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF8	O76064	376	412	403	403	Mutagenesis	Note=Marked reduction of E2-dependent ubiquitination of histone H2A. Loss of UBE2E2- and UBE2N-binding. Loss of nuclear localization. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11322894,ECO:0000269|PubMed:14981089,ECO:0000269|PubMed:16215985,ECO:0000269|PubMed:18001824;Dbxref=PMID:11322894,PMID:14981089,PMID:16215985,PMID:18001824
RNF8	O76064	376	412	405	405	Mutagenesis	Note=Impairs interaction with UBE2L6/UBCH8 and ability to mediate 'Lys-48'-linked ubiquitination E3 ligase activity%2C while it still catalyzes 'Lys-63'-linked ubiquitination and still interacts with UBE2N/UBC13. I->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21911360,ECO:0000269|PubMed:22373579,ECO:0000269|PubMed:22589545;Dbxref=PMID:21911360,PMID:22373579,PMID:22589545
RNF8	O76064	376	412	406	406	Mutagenesis	Note=Abolishes ubiquitin-ligase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21857671;Dbxref=PMID:21857671
RNF8	O76064	325	346	334	334	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF8	O76064	346	376	351	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AYC
RNF8	O76064	376	412	351	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AYC
RNF8	O76064	376	412	404	406	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AYC
RNF8	O76064	376	412	411	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AYC
ROR2	Q01974	312	394	34	943	Chain	ID=PRO_0000024460;Note=Tyrosine-protein kinase transmembrane receptor ROR2
ROR2	Q01974	207	312	34	943	Chain	ID=PRO_0000024460;Note=Tyrosine-protein kinase transmembrane receptor ROR2
ROR2	Q01974	312	394	34	403	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROR2	Q01974	207	312	34	403	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROR2	Q01974	207	312	169	303	Domain	Note=FZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00090
ROR2	Q01974	312	394	316	394	Domain	Note=Kringle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00121
ROR2	Q01974	312	394	318	318	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ROR2	Q01974	207	312	174	239	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	207	312	182	232	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	207	312	223	264	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	207	312	252	300	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	207	312	256	286	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	312	394	316	394	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	312	394	337	377	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	312	394	365	389	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ROR2	Q01974	207	312	244	244	Natural variant	ID=VAR_041787;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55737262,PMID:17344846
ROR2	Q01974	207	312	245	245	Natural variant	ID=VAR_010912;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10700182,ECO:0000269|PubMed:10986040,ECO:0000269|PubMed:1334494,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.3;Dbxref=dbSNP:rs10820900,PMID:10700182,PMID:10986040,PMID:1334494,PMID:17344846
ROR2	Q01974	312	394	349	349	Natural variant	ID=VAR_041788;Note=H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55983376,PMID:17344846
ROR2	Q01974	312	394	366	366	Natural variant	ID=VAR_010770;Note=In RRS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10932186;Dbxref=PMID:10932186
RPAP3	Q9H6T3	395	429	2	665	Chain	ID=PRO_0000302794;Note=RNA polymerase II-associated protein 3
RPAP3	Q9H6T3	98	139	2	665	Chain	ID=PRO_0000302794;Note=RNA polymerase II-associated protein 3
RPAP3	Q9H6T3	98	139	133	166	Repeat	Note=TPR 2
RPAP3	Q9H6T3	98	139	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
RPAP3	Q9H6T3	98	139	119	119	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:21406692,PMID:24275569
RPAP3	Q9H6T3	98	139	121	121	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
RPAP3	Q9H6T3	98	139	1	159	Alternative sequence	ID=VSP_044882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPAP3	Q9H6T3	395	429	396	429	Alternative sequence	ID=VSP_027957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPAP3	Q9H6T3	98	139	130	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CGV
MRPL2	Q5T653	173	210	61	305	Chain	ID=PRO_0000261640;Note=39S ribosomal protein L2%2C mitochondrial
MRPL2	Q5T653	173	210	181	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL2	Q5T653	173	210	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL2	Q5T653	173	210	192	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL2	Q5T653	173	210	200	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOL
MRPL2	Q5T653	173	210	204	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOL
POLR1C	O15160	47	83	2	346	Chain	ID=PRO_0000132739;Note=DNA-directed RNA polymerases I and III subunit RPAC1
POLR1C	O15160	127	167	2	346	Chain	ID=PRO_0000132739;Note=DNA-directed RNA polymerases I and III subunit RPAC1
POLR1C	O15160	167	218	2	346	Chain	ID=PRO_0000132739;Note=DNA-directed RNA polymerases I and III subunit RPAC1
POLR1C	O15160	218	268	2	346	Chain	ID=PRO_0000132739;Note=DNA-directed RNA polymerases I and III subunit RPAC1
POLR1C	O15160	47	83	65	65	Natural variant	ID=VAR_074657;Note=In HLD11. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26151409;Dbxref=dbSNP:rs141471029,PMID:26151409
POLR1C	O15160	47	83	74	74	Natural variant	ID=VAR_074658;Note=In HLD11%3B decreased localization to the nucleus and retained in the cytoplasm%3B loss of association with RNA polymerase III-transcribed genes%3B decreased association with RNA polymerase III complex%3B probably prevents RNA polymerase III complex assembly and activity. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26151409;Dbxref=dbSNP:rs371802902,PMID:26151409
POLR1C	O15160	127	167	132	132	Natural variant	ID=VAR_074661;Note=In HLD11. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26151409;Dbxref=dbSNP:rs201320592,PMID:26151409
POLR1C	O15160	127	167	146	146	Natural variant	ID=VAR_074662;Note=In HLD11. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26151409;Dbxref=dbSNP:rs796052125,PMID:26151409
POLR1C	O15160	167	218	191	191	Natural variant	ID=VAR_074663;Note=In HLD11. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26151409;Dbxref=dbSNP:rs373046018,PMID:26151409
POLR1C	O15160	218	268	262	262	Natural variant	ID=VAR_074664;Note=In HLD11. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26151409;Dbxref=dbSNP:rs751006626,PMID:26151409
POLR2B	P30876	468	516	1	1174	Chain	ID=PRO_0000048085;Note=DNA-directed RNA polymerase II subunit RPB2
POLR2B	P30876	952	988	1	1174	Chain	ID=PRO_0000048085;Note=DNA-directed RNA polymerase II subunit RPB2
POLR2B	P30876	468	516	1	1174	Chain	ID=PRO_0000048085;Note=DNA-directed RNA polymerase II subunit RPB2
POLR2B	P30876	952	988	1	1174	Chain	ID=PRO_0000048085;Note=DNA-directed RNA polymerase II subunit RPB2
RIOK2	Q9BVS4	260	290	1	552	Chain	ID=PRO_0000213527;Note=Serine/threonine-protein kinase RIO2
RIOK2	Q9BVS4	68	107	1	552	Chain	ID=PRO_0000213527;Note=Serine/threonine-protein kinase RIO2
RIOK2	Q9BVS4	260	290	97	272	Domain	Note=Protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305
RIOK2	Q9BVS4	68	107	97	272	Domain	Note=Protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305
RIOK2	Q9BVS4	68	107	96	96	Natural variant	ID=VAR_042347;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2544773,PMID:17344846
POLR3B	Q9NW08	282	322	1	1133	Chain	ID=PRO_0000048092;Note=DNA-directed RNA polymerase III subunit RPC2
POLR3B	Q9NW08	1033	1090	1	1133	Chain	ID=PRO_0000048092;Note=DNA-directed RNA polymerase III subunit RPC2
POLR3B	Q9NW08	1033	1090	1080	1095	Zinc finger	Note=C4-type
POLR3B	Q9NW08	1033	1090	1080	1080	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR3B	Q9NW08	1033	1090	1083	1083	Metal binding	Note=Zinc;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR3C	Q9BUI4	458	507	1	534	Chain	ID=PRO_0000073963;Note=DNA-directed RNA polymerase III subunit RPC3
POLR3C	Q9BUI4	292	319	1	534	Chain	ID=PRO_0000073963;Note=DNA-directed RNA polymerase III subunit RPC3
POLR3C	Q9BUI4	292	319	312	312	Mutagenesis	Note=Loss of interaction with POLR3G and POLR3GL. No effect on interaction with POLR3F. L->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358628;Dbxref=PMID:21358628
POLR3C	Q9BUI4	458	507	466	470	Mutagenesis	Note=Mild decrease in ssDNA-binding. No effect on interaction with POLR3F%2C POLR3G%2C nor with POLR3GL. RVEAI->EVEAF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358628;Dbxref=PMID:21358628
POLR3C	Q9BUI4	292	319	290	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XUB
POLR3C	Q9BUI4	292	319	305	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XUB
POLR3C	Q9BUI4	458	507	458	472	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XUB
POLR3C	Q9BUI4	458	507	485	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XUB
POLR3C	Q9BUI4	458	507	493	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XUB
RIMS2	Q9UQ26	854	913	1	1411	Chain	ID=PRO_0000190201;Note=Regulating synaptic membrane exocytosis protein 2
RIMS2	Q9UQ26	854	913	807	913	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
RIMS2	Q9UQ26	854	913	1	1126	Alternative sequence	ID=VSP_040864;Note=In isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RIMS2	Q9UQ26	854	913	802	1411	Alternative sequence	ID=VSP_040871;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
RIMS2	Q9UQ26	854	913	825	1411	Alternative sequence	ID=VSP_040870;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
RIMS2	Q9UQ26	854	913	854	857	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V27
RIMS2	Q9UQ26	854	913	885	887	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V27
RIMS2	Q9UQ26	854	913	890	898	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V27
RIMS2	Q9UQ26	854	913	900	903	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V27
RIMS2	Q9UQ26	854	913	910	915	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1V27
RNF2	Q99496	83	154	2	336	Chain	ID=PRO_0000056038;Note=E3 ubiquitin-protein ligase RING2
RNF2	Q99496	155	245	2	336	Chain	ID=PRO_0000056038;Note=E3 ubiquitin-protein ligase RING2
RNF2	Q99496	83	154	51	91	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF2	Q99496	83	154	2	179	Region	Note=Interaction with HIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513855;Dbxref=PMID:11513855
RNF2	Q99496	155	245	2	179	Region	Note=Interaction with HIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11513855;Dbxref=PMID:11513855
RNF2	Q99496	83	154	93	98	Region	Note=Interaction with nucleosomes via an acidic patch on histone H2A and histone H2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355358;Dbxref=PMID:25355358
RNF2	Q99496	83	154	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RNF2	Q99496	155	245	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:25519132;Dbxref=PMID:23186163,PMID:25519132
RNF2	Q99496	83	154	112	112	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CQJ4
RNF2	Q99496	83	154	84	155	Alternative sequence	ID=VSP_055439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF2	Q99496	155	245	84	155	Alternative sequence	ID=VSP_055439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF2	Q99496	83	154	93	93	Mutagenesis	Note=Mildly decreases ubiquitin ligase activity on histone H2A. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355358;Dbxref=PMID:25355358
RNF2	Q99496	83	154	97	98	Mutagenesis	Note=Loss of ubiquitin ligase activity on histone H2A. KR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21772249;Dbxref=PMID:21772249
RNF2	Q99496	83	154	97	97	Mutagenesis	Note=Strongly decreases ubiquitin ligase activity on histone H2A. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355358;Dbxref=PMID:25355358
RNF2	Q99496	83	154	98	98	Mutagenesis	Note=Nearly abolishes ubiquitin ligase activity on histone H2A. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355358;Dbxref=PMID:25355358
RNF2	Q99496	155	245	168	168	Mutagenesis	Note=Decreases ubiquitin ligase activity on histone H2A. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25519132;Dbxref=PMID:25519132
RNF2	Q99496	83	154	88	90	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4S3O
RNF2	Q99496	83	154	97	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4S3O
RNF2	Q99496	83	154	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4S3O
RNF2	Q99496	83	154	104	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4S3O
RNF2	Q99496	155	245	225	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GS2
RNF2	Q99496	155	245	234	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GS2
POC1A	Q8NBT0	327	375	1	407	Chain	ID=PRO_0000231522;Note=POC1 centriolar protein homolog A
POC1A	Q8NBT0	294	327	1	407	Chain	ID=PRO_0000231522;Note=POC1 centriolar protein homolog A
POC1A	Q8NBT0	294	327	269	308	Repeat	Note=WD 7
POC1A	Q8NBT0	327	375	369	397	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
POC1A	Q8NBT0	327	375	328	375	Alternative sequence	ID=VSP_017836;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
POC1A	Q8NBT0	327	375	348	348	Natural variant	ID=VAR_057628;Note=Q->H;Dbxref=dbSNP:rs35898691
POMT2	Q9UKY4	630	677	1	750	Chain	ID=PRO_0000121488;Note=Protein O-mannosyl-transferase 2
POMT2	Q9UKY4	575	595	1	750	Chain	ID=PRO_0000121488;Note=Protein O-mannosyl-transferase 2
POMT2	Q9UKY4	630	677	643	663	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
POMT2	Q9UKY4	630	677	665	685	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
POMT2	Q9UKY4	575	595	583	583	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
POMT2	Q9UKY4	630	677	83	750	Alternative sequence	ID=VSP_041457;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
POMT2	Q9UKY4	575	595	83	750	Alternative sequence	ID=VSP_041457;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
POMT2	Q9UKY4	630	677	666	666	Natural variant	ID=VAR_065045;Note=In MDDGB2 and MDDGA2. Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17634419,ECO:0000269|PubMed:17878207,ECO:0000269|PubMed:19138766,ECO:0000269|PubMed:19299310;Dbxref=dbSNP:rs200198778,PMID:17634419,PMID:17878207,PMID:19138766,PMID:19299310
PPP1R12C	Q9BZL4	737	754	2	782	Chain	ID=PRO_0000315863;Note=Protein phosphatase 1 regulatory subunit 12C
PPP1R12C	Q9BZL4	737	754	681	782	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RERE	Q9P2R6	482	513	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	401	428	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	368	401	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	242	276	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	132	174	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	482	513	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	401	428	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	368	401	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	242	276	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	132	174	1	1566	Chain	ID=PRO_0000083504;Note=Arginine-glutamic acid dipeptide repeats protein
RERE	Q9P2R6	242	276	103	283	Domain	Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
RERE	Q9P2R6	132	174	103	283	Domain	Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
RERE	Q9P2R6	242	276	103	283	Domain	Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
RERE	Q9P2R6	132	174	103	283	Domain	Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
RERE	Q9P2R6	368	401	284	387	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
RERE	Q9P2R6	368	401	284	387	Domain	Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512
RERE	Q9P2R6	401	428	391	443	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
RERE	Q9P2R6	368	401	391	443	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
RERE	Q9P2R6	401	428	391	443	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
RERE	Q9P2R6	368	401	391	443	Domain	Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
RERE	Q9P2R6	482	513	507	532	Zinc finger	Note=GATA-type
RERE	Q9P2R6	482	513	507	532	Zinc finger	Note=GATA-type
RERE	Q9P2R6	132	174	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80TZ9
RERE	Q9P2R6	132	174	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80TZ9
RERE	Q9P2R6	482	513	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	401	428	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	368	401	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	242	276	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	132	174	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	482	513	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	401	428	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	368	401	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	242	276	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	132	174	1	554	Alternative sequence	ID=VSP_016878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
RERE	Q9P2R6	401	428	398	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	368	401	398	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	401	428	398	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	368	401	398	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	401	428	415	421	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	401	428	415	421	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	401	428	428	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
RERE	Q9P2R6	401	428	428	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YQK
PPP1CB	P62140	61	138	2	327	Chain	ID=PRO_0000058779;Note=Serine/threonine-protein phosphatase PP1-beta catalytic subunit
PPP1CB	P62140	61	138	2	327	Chain	ID=PRO_0000058779;Note=Serine/threonine-protein phosphatase PP1-beta catalytic subunit
PPP1CB	P62140	61	138	2	327	Chain	ID=PRO_0000058779;Note=Serine/threonine-protein phosphatase PP1-beta catalytic subunit
PPP1CB	P62140	61	138	124	124	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	124	124	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	124	124	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	63	63	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	63	63	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	63	63	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	65	65	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	65	65	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	65	65	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	91	91	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	91	91	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	91	91	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	91	91	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	91	91	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	91	91	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	123	123	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	123	123	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CB	P62140	61	138	123	123	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
RBP5	P82980	84	118	1	135	Chain	ID=PRO_0000067400;Note=Retinol-binding protein 5
RBP5	P82980	84	118	115	115	Natural variant	ID=VAR_034446;Note=M->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2290237,PMID:14702039
RBP5	P82980	84	118	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GGL
RBP5	P82980	84	118	91	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GGL
RBP5	P82980	84	118	106	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GGL
RBP5	P82980	84	118	115	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GGL
RBP7	Q96R05	84	118	1	134	Chain	ID=PRO_0000067403;Note=Retinoid-binding protein 7
RBP7	Q96R05	84	118	83	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AT8
RBP7	Q96R05	84	118	93	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AT8
RBP7	Q96R05	84	118	106	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AT8
RBP7	Q96R05	84	118	115	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AT8
RNF17	Q9BXT8	413	466	1	1623	Chain	ID=PRO_0000183165;Note=RING finger protein 17
RNF17	Q9BXT8	413	466	414	449	Alternative sequence	ID=VSP_005753;Note=In isoform 3. SSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVN->TCGTDDLGETPRYPKKPLQKNSSVPFGSKADTVTTV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11279525;Dbxref=PMID:11279525
RNF17	Q9BXT8	413	466	450	1623	Alternative sequence	ID=VSP_005754;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11279525;Dbxref=PMID:11279525
RPH3A	Q9Y2J0	28	76	1	694	Chain	ID=PRO_0000190227;Note=Rabphilin-3A
RPH3A	Q9Y2J0	28	76	1	694	Chain	ID=PRO_0000190227;Note=Rabphilin-3A
RPH3A	Q9Y2J0	28	76	1	694	Chain	ID=PRO_0000190227;Note=Rabphilin-3A
RPH3A	Q9Y2J0	28	76	44	160	Domain	Note=RabBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00234
RPH3A	Q9Y2J0	28	76	44	160	Domain	Note=RabBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00234
RPH3A	Q9Y2J0	28	76	44	160	Domain	Note=RabBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00234
RPH3A	Q9Y2J0	28	76	24	28	Alternative sequence	ID=VSP_021016;Note=In isoform 2. NDKEQ->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPH3A	Q9Y2J0	28	76	24	28	Alternative sequence	ID=VSP_021016;Note=In isoform 2. NDKEQ->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPH3A	Q9Y2J0	28	76	24	28	Alternative sequence	ID=VSP_021016;Note=In isoform 2. NDKEQ->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLR2E	P19388	116	143	1	210	Chain	ID=PRO_0000146075;Note=DNA-directed RNA polymerases I%2C II%2C and III subunit RPABC1
POLR2E	P19388	116	143	132	132	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLR2E	P19388	116	143	132	132	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLR1A	O95602	1191	1246	1	1720	Chain	ID=PRO_0000073923;Note=DNA-directed RNA polymerase I subunit RPA1
POLR1A	O95602	911	962	1	1720	Chain	ID=PRO_0000073923;Note=DNA-directed RNA polymerase I subunit RPA1
POLR1A	O95602	460	537	1	1720	Chain	ID=PRO_0000073923;Note=DNA-directed RNA polymerase I subunit RPA1
POLR1A	O95602	243	272	1	1720	Chain	ID=PRO_0000073923;Note=DNA-directed RNA polymerase I subunit RPA1
POLR1A	O95602	911	962	961	973	Region	Note=Bridging helix;Ontology_term=ECO:0000250;evidence=ECO:0000250
POLR1A	O95602	911	962	925	926	Sequence conflict	Note=RP->ST;Ontology_term=ECO:0000305;evidence=ECO:0000305
RORA	P35398	174	306	1	523	Chain	ID=PRO_0000053512;Note=Nuclear receptor ROR-alpha
RORA	P35398	174	306	272	510	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
RORA	P35398	174	306	139	271	Region	Note=Hinge
RORA	P35398	174	306	183	183	Modified residue	Note=Phosphothreonine%3B by MAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512500;Dbxref=PMID:17512500
RORA	P35398	174	306	240	240	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19041634;Dbxref=PMID:19041634
RORA	P35398	174	306	183	183	Mutagenesis	Note=Greatly increased transcriptional activity. Decrease in repression by NR1D1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512500;Dbxref=PMID:17512500
RORA	P35398	174	306	183	183	Mutagenesis	Note=Some increase in transcriptional activity. No change in repression by NR1D1. T->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512500;Dbxref=PMID:17512500
RORA	P35398	174	306	183	183	Mutagenesis	Note=Attenuates transcriptional activity. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512500;Dbxref=PMID:17512500
RORA	P35398	174	306	183	183	Mutagenesis	Note=Some increase in transcriptional activity. T->V%2CI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17512500;Dbxref=PMID:17512500
RORA	P35398	174	306	240	240	Mutagenesis	Note=Loss of sumoylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19041634;Dbxref=PMID:19041634
RORA	P35398	174	306	288	288	Mutagenesis	Note=Less effect on transcriptional activity with cholesterol sulfate as substrate as compared to cholesterol as substrate. C->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722075;Dbxref=PMID:14722075
RORA	P35398	174	306	271	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N83
RORA	P35398	174	306	292	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N83
RORA	P35398	174	306	298	300	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N83
RORA	P35398	174	306	305	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N83
SLIT2	O94813	132	155	31	1529	Chain	ID=PRO_0000007725;Note=Slit homolog 2 protein
SLIT2	O94813	353	376	31	1529	Chain	ID=PRO_0000007725;Note=Slit homolog 2 protein
SLIT2	O94813	782	805	31	1529	Chain	ID=PRO_0000007725;Note=Slit homolog 2 protein
SLIT2	O94813	132	155	31	1121	Chain	ID=PRO_0000007726;Note=Slit homolog 2 protein N-product
SLIT2	O94813	353	376	31	1121	Chain	ID=PRO_0000007726;Note=Slit homolog 2 protein N-product
SLIT2	O94813	782	805	31	1121	Chain	ID=PRO_0000007726;Note=Slit homolog 2 protein N-product
SLIT2	O94813	132	155	128	149	Repeat	Note=LRR 4
SLIT2	O94813	132	155	152	173	Repeat	Note=LRR 5
SLIT2	O94813	353	376	349	370	Repeat	Note=LRR 9
SLIT2	O94813	353	376	373	394	Repeat	Note=LRR 10
SLIT2	O94813	782	805	778	799	Repeat	Note=LRR 18
SLIT2	O94813	782	805	802	823	Repeat	Note=LRR 19
SLIT2	O94813	782	805	794	794	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLIT2	O94813	782	805	799	799	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLIT2	O94813	353	376	352	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9T
SLIT2	O94813	353	376	365	370	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9T
SLIT2	O94813	353	376	376	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9T
SLIT2	O94813	782	805	781	783	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFH
SLIT2	O94813	782	805	794	799	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFH
SLIT2	O94813	782	805	805	807	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFH
ROCK1	Q13464	92	138	2	1354	Chain	ID=PRO_0000086619;Note=Rho-associated protein kinase 1
ROCK1	Q13464	92	138	76	338	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK1	Q13464	92	138	105	105	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK1	Q13464	92	138	108	108	Natural variant	ID=VAR_041055;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55811609,PMID:17344846
ROCK1	Q13464	92	138	86	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	96	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	101	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	121	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
POLR1D	P0DPB6	9	33	1	133	Chain	ID=PRO_0000149316;Note=DNA-directed RNA polymerases I and III subunit RPAC2
RPL35A	P18077	4	54	1	110	Chain	ID=PRO_0000192796;Note=60S ribosomal protein L35a
RPL35A	P18077	4	54	1	110	Chain	ID=PRO_0000192796;Note=60S ribosomal protein L35a
RPL35A	P18077	4	54	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL35A	P18077	4	54	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL35A	P18077	4	54	27	27	Natural variant	ID=VAR_055446;Note=In DBA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=PMID:18535205
RPL35A	P18077	4	54	27	27	Natural variant	ID=VAR_055446;Note=In DBA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=PMID:18535205
RPL35A	P18077	4	54	33	33	Natural variant	ID=VAR_055447;Note=In DBA5%3B may result in aberrant splicing. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=dbSNP:rs116840808,PMID:18535205
RPL35A	P18077	4	54	33	33	Natural variant	ID=VAR_055447;Note=In DBA5%3B may result in aberrant splicing. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=dbSNP:rs116840808,PMID:18535205
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL5	P46777	63	108	2	297	Chain	ID=PRO_0000131431;Note=60S ribosomal protein L5
RPL5	P46777	63	108	78	78	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL8	P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
RPL8	P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
RPL8	P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
RPL8	P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
RPL8	P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
RPL8	P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
MRPL37	Q9BZE1	215	277	30	423	Chain	ID=PRO_0000045905;Note=39S ribosomal protein L37%2C mitochondrial
MRPL37	Q9BZE1	215	277	206	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	218	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	242	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	257	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	261	264	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	265	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
RNF145	Q96MT1	313	373	1	663	Chain	ID=PRO_0000294024;Note=RING finger protein 145
RNF145	Q96MT1	313	373	1	663	Chain	ID=PRO_0000294024;Note=RING finger protein 145
RNF145	Q96MT1	313	373	316	336	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF145	Q96MT1	313	373	316	336	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF145	Q96MT1	313	373	340	360	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF145	Q96MT1	313	373	340	360	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RND1	Q92730	106	151	1	229	Chain	ID=PRO_0000198874;Note=Rho-related GTP-binding protein Rho6
RND1	Q92730	106	151	125	128	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2CLS,ECO:0000269|PubMed:19843518;Dbxref=PMID:19843518
RND1	Q92730	106	151	106	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q3J
RND1	Q92730	106	151	118	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q3J
RND1	Q92730	106	151	127	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q3J
RND1	Q92730	106	151	133	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q3J
RND1	Q92730	106	151	149	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q3J
RNF13	O43567	65	107	35	381	Chain	ID=PRO_0000056054;Note=E3 ubiquitin-protein ligase RNF13
RNF13	O43567	233	260	35	381	Chain	ID=PRO_0000056054;Note=E3 ubiquitin-protein ligase RNF13
RNF13	O43567	65	107	35	381	Chain	ID=PRO_0000056054;Note=E3 ubiquitin-protein ligase RNF13
RNF13	O43567	233	260	35	381	Chain	ID=PRO_0000056054;Note=E3 ubiquitin-protein ligase RNF13
RNF13	O43567	65	107	35	182	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF13	O43567	65	107	35	182	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF13	O43567	233	260	204	381	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF13	O43567	233	260	204	381	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF13	O43567	65	107	65	160	Domain	Note=PA
RNF13	O43567	65	107	65	160	Domain	Note=PA
RNF13	O43567	233	260	240	282	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF13	O43567	233	260	240	282	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
RNF13	O43567	65	107	88	88	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	65	107	88	88	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	65	107	19	137	Alternative sequence	ID=VSP_055431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF13	O43567	65	107	19	137	Alternative sequence	ID=VSP_055431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF13	O43567	65	107	88	88	Mutagenesis	Note=Loss of glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	65	107	88	88	Mutagenesis	Note=Loss of glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	233	260	258	258	Mutagenesis	Note=Complete loss of E3 ligase activity%3B when associated with A-260. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	233	260	258	258	Mutagenesis	Note=Complete loss of E3 ligase activity%3B when associated with A-260. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	233	260	260	260	Mutagenesis	Note=Complete loss of E3 ligase activity%3B when associated with A-258. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF13	O43567	233	260	260	260	Mutagenesis	Note=Complete loss of E3 ligase activity%3B when associated with A-258. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794910;Dbxref=PMID:18794910
RNF24	Q9Y225	62	76	1	148	Chain	ID=PRO_0000056063;Note=RING finger protein 24
RNF24	Q9Y225	62	76	1	148	Chain	ID=PRO_0000056063;Note=RING finger protein 24
VAC14	Q08AM6	141	162	1	782	Chain	ID=PRO_0000300485;Note=Protein VAC14 homolog
VAC14	Q08AM6	141	162	1	568	Alternative sequence	ID=VSP_056097;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VAT1L	Q9HCJ6	294	359	1	419	Chain	ID=PRO_0000160922;Note=Synaptic vesicle membrane protein VAT-1 homolog-like
VAT1L	Q9HCJ6	294	359	303	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A27
VAT1L	Q9HCJ6	294	359	312	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A27
VAT1L	Q9HCJ6	294	359	318	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A27
VAT1L	Q9HCJ6	294	359	328	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A27
VAT1L	Q9HCJ6	294	359	351	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A27
VAT1L	Q9HCJ6	294	359	357	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A27
VPS13C	Q709C8	3408	3446	1	3753	Chain	ID=PRO_0000262949;Note=Vacuolar protein sorting-associated protein 13C
VPS13C	Q709C8	2354	2404	1	3753	Chain	ID=PRO_0000262949;Note=Vacuolar protein sorting-associated protein 13C
VPS13C	Q709C8	2172	2203	1	3753	Chain	ID=PRO_0000262949;Note=Vacuolar protein sorting-associated protein 13C
VPS13C	Q709C8	1512	1532	1	3753	Chain	ID=PRO_0000262949;Note=Vacuolar protein sorting-associated protein 13C
VPS13C	Q709C8	149	171	1	3753	Chain	ID=PRO_0000262949;Note=Vacuolar protein sorting-associated protein 13C
VPS13C	Q709C8	128	149	1	3753	Chain	ID=PRO_0000262949;Note=Vacuolar protein sorting-associated protein 13C
VPS13C	Q709C8	149	171	145	179	Compositional bias	Note=Lys-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
VPS13C	Q709C8	128	149	145	179	Compositional bias	Note=Lys-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
VPS13C	Q709C8	128	149	132	132	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BX70
VPS13C	Q709C8	149	171	129	171	Alternative sequence	ID=VSP_052243;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498460;Dbxref=PMID:15498460
VPS13C	Q709C8	128	149	129	171	Alternative sequence	ID=VSP_052243;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498460;Dbxref=PMID:15498460
VPS13C	Q709C8	149	171	153	153	Natural variant	ID=VAR_029548;Note=R->H;Dbxref=dbSNP:rs12595158
VPS26B	Q4G0F5	127	181	1	336	Chain	ID=PRO_0000247089;Note=Vacuolar protein sorting-associated protein 26B
VPS26B	Q4G0F5	127	181	1	336	Chain	ID=PRO_0000247089;Note=Vacuolar protein sorting-associated protein 26B
VPS9D1	Q9Y2B5	566	600	1	631	Chain	ID=PRO_0000079279;Note=VPS9 domain-containing protein 1
VPS9D1	Q9Y2B5	181	202	1	631	Chain	ID=PRO_0000079279;Note=VPS9 domain-containing protein 1
VPS9D1	Q9Y2B5	58	89	1	631	Chain	ID=PRO_0000079279;Note=VPS9 domain-containing protein 1
VPS9D1	Q9Y2B5	566	600	467	630	Domain	Note=VPS9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00550
VPS9D1	Q9Y2B5	181	202	187	221	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
VSTM5	A8MXK1	139	186	29	200	Chain	ID=PRO_0000340693;Note=V-set and transmembrane domain-containing protein 5
VSTM5	A8MXK1	139	186	29	147	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSTM5	A8MXK1	139	186	148	168	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSTM5	A8MXK1	139	186	169	200	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSTM5	A8MXK1	139	186	37	139	Domain	Note=Ig-like C2-type
VSTM5	A8MXK1	139	186	170	186	Region	Note=Important for CDC42-dependent filopodia induction;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D806
WBP4	O75554	25	46	1	376	Chain	ID=PRO_0000076065;Note=WW domain-binding protein 4
WBP4	O75554	25	46	11	42	Zinc finger	Note=Matrin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00130
WBP4	O75554	25	46	26	46	Alternative sequence	ID=VSP_056413;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR17	Q8IZU2	534	588	1	1322	Chain	ID=PRO_0000051364;Note=WD repeat-containing protein 17
WDR17	Q8IZU2	534	588	519	559	Repeat	Note=WD 9
WDR17	Q8IZU2	534	588	564	604	Repeat	Note=WD 10
WDR36	Q8NI36	655	690	1	951	Chain	ID=PRO_0000051386;Note=WD repeat-containing protein 36
WDR36	Q8NI36	655	690	620	661	Repeat	Note=WD 13
WDR36	Q8NI36	655	690	663	701	Repeat	Note=WD 14
WDR36	Q8NI36	655	690	658	658	Natural variant	ID=VAR_025969;Note=D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15677485,ECO:0000269|PubMed:18172102;Dbxref=dbSNP:rs34595252,PMID:15677485,PMID:18172102
WDR36	Q8NI36	655	690	671	671	Natural variant	ID=VAR_025970;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15677485;Dbxref=dbSNP:rs11956837,PMID:15677485
WDR36	Q8NI36	655	690	686	686	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR3	Q9UNX4	193	225	1	943	Chain	ID=PRO_0000051347;Note=WD repeat-containing protein 3
WDR3	Q9UNX4	787	803	1	943	Chain	ID=PRO_0000051347;Note=WD repeat-containing protein 3
WDR3	Q9UNX4	818	860	1	943	Chain	ID=PRO_0000051347;Note=WD repeat-containing protein 3
WDR3	Q9UNX4	193	225	189	228	Repeat	Note=WD 5
WDR43	Q15061	479	508	1	677	Chain	ID=PRO_0000051392;Note=WD repeat-containing protein 43
WDR43	Q15061	540	578	1	677	Chain	ID=PRO_0000051392;Note=WD repeat-containing protein 43
WDR78	Q5VTH9	671	704	1	848	Chain	ID=PRO_0000262773;Note=WD repeat-containing protein 78
WDR78	Q5VTH9	498	527	1	848	Chain	ID=PRO_0000262773;Note=WD repeat-containing protein 78
WDR78	Q5VTH9	365	430	1	848	Chain	ID=PRO_0000262773;Note=WD repeat-containing protein 78
WDR78	Q5VTH9	313	365	1	848	Chain	ID=PRO_0000262773;Note=WD repeat-containing protein 78
WDR78	Q5VTH9	671	704	658	698	Repeat	Note=WD 3
WDR78	Q5VTH9	671	704	702	742	Repeat	Note=WD 4
WDR78	Q5VTH9	671	704	546	848	Alternative sequence	ID=VSP_021817;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR78	Q5VTH9	671	704	672	704	Alternative sequence	ID=VSP_021815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR63	Q8IWG1	21	34	1	891	Chain	ID=PRO_0000233162;Note=WD repeat-containing protein 63
WDR63	Q8IWG1	95	130	1	891	Chain	ID=PRO_0000233162;Note=WD repeat-containing protein 63
WDR63	Q8IWG1	247	285	1	891	Chain	ID=PRO_0000233162;Note=WD repeat-containing protein 63
WDR63	Q8IWG1	247	285	247	286	Alternative sequence	ID=VSP_018080;Note=In isoform 2. WTYPKNATTQYYPREFSEEEKETLKQSKPLVDFLNNASIS->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR63	Q8IWG1	95	130	108	108	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR45B	Q5MNZ6	235	268	1	344	Chain	ID=PRO_0000051445;Note=WD repeat domain phosphoinositide-interacting protein 3
WDR45B	Q5MNZ6	47	81	1	344	Chain	ID=PRO_0000051445;Note=WD repeat domain phosphoinositide-interacting protein 3
WDR45B	Q5MNZ6	47	81	44	87	Repeat	Note=WD 2
WDR45B	Q5MNZ6	235	268	220	259	Repeat	Note=WD 6
WDR45B	Q5MNZ6	235	268	265	314	Repeat	Note=WD 7
WDR45B	Q5MNZ6	47	81	56	57	Sequence conflict	Note=HV->TR;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR45B	Q5MNZ6	47	81	69	69	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR45B	Q5MNZ6	235	268	254	254	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFYVE9	O95405	759	818	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	915	956	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	956	1008	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	1111	1146	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	1196	1223	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	759	818	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	915	956	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	956	1008	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	1111	1146	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	1196	1223	1	1425	Chain	ID=PRO_0000098715;Note=Zinc finger FYVE domain-containing protein 9
ZFYVE9	O95405	759	818	767	823	Region	Note=SBD
ZFYVE9	O95405	759	818	767	823	Region	Note=SBD
ZFYVE9	O95405	759	818	760	818	Alternative sequence	ID=VSP_004315;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	759	818	760	818	Alternative sequence	ID=VSP_004315;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	759	818	760	762	Alternative sequence	ID=VSP_004316;Note=In isoform 3. AQA->GKY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	759	818	760	762	Alternative sequence	ID=VSP_004316;Note=In isoform 3. AQA->GKY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	759	818	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	915	956	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	956	1008	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	1111	1146	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	1196	1223	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	759	818	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	915	956	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	956	1008	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	1111	1146	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	1196	1223	763	1425	Alternative sequence	ID=VSP_004317;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9582421;Dbxref=PMID:9582421
ZFYVE9	O95405	759	818	782	782	Mutagenesis	Note=Diminishes complex formation with SMAD2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	782	782	Mutagenesis	Note=Diminishes complex formation with SMAD2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	782	782	Mutagenesis	Note=Diminishes complex formation with SMAD2. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	782	782	Mutagenesis	Note=Diminishes complex formation with SMAD2. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	783	783	Mutagenesis	Note=Diminishes complex formation with SMAD2. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	783	783	Mutagenesis	Note=Diminishes complex formation with SMAD2. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	783	783	Mutagenesis	Note=Diminishes complex formation with SMAD2. C->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	783	783	Mutagenesis	Note=Diminishes complex formation with SMAD2. C->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	788	788	Mutagenesis	Note=Diminishes complex formation with SMAD2. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	788	788	Mutagenesis	Note=Diminishes complex formation with SMAD2. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	788	788	Mutagenesis	Note=Diminishes complex formation with SMAD2. P->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	788	788	Mutagenesis	Note=Diminishes complex formation with SMAD2. P->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	790	790	Mutagenesis	Note=No effect on complex formation with SMAD2. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	790	790	Mutagenesis	Note=No effect on complex formation with SMAD2. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	793	793	Mutagenesis	Note=No effect on complex formation with SMAD2. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	793	793	Mutagenesis	Note=No effect on complex formation with SMAD2. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	805	805	Mutagenesis	Note=Diminishes complex formation with SMAD2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	805	805	Mutagenesis	Note=Diminishes complex formation with SMAD2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	805	805	Mutagenesis	Note=Diminishes complex formation with SMAD2. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	805	805	Mutagenesis	Note=Diminishes complex formation with SMAD2. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10615055;Dbxref=PMID:10615055
ZFYVE9	O95405	759	818	779	781	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	779	781	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	788	792	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	788	792	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	793	795	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	793	795	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	797	800	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MK2
ZFYVE9	O95405	759	818	797	800	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MK2
ZFYVE9	O95405	759	818	804	807	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	759	818	804	807	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEV
ZFYVE9	O95405	915	956	918	922	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	918	922	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	925	932	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	925	932	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	940	945	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	940	945	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	948	957	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	948	957	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	915	956	948	957	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	948	957	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	960	970	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	960	970	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	971	973	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	971	973	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	977	983	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	977	983	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	994	1007	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	956	1008	994	1007	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1113	1115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1113	1115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1127	1131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1127	1131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1134	1140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1134	1140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1141	1143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1141	1143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1144	1152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1111	1146	1144	1152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1196	1223	1196	1199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1196	1223	1196	1199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1196	1223	1201	1207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1196	1223	1201	1207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1196	1223	1218	1222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZFYVE9	O95405	1196	1223	1218	1222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKW
ZNF549	Q6P9A3	11	24	1	640	Chain	ID=PRO_0000234583;Note=Zinc finger protein 549
ZNF549	Q6P9A3	11	24	12	24	Alternative sequence	ID=VSP_018379;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF692	Q9BU19	294	319	1	519	Chain	ID=PRO_0000234014;Note=Zinc finger protein 692
ZNF692	Q9BU19	175	219	1	519	Chain	ID=PRO_0000234014;Note=Zinc finger protein 692
ZNF692	Q9BU19	175	219	88	259	Alternative sequence	ID=VSP_018186;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF692	Q9BU19	294	319	97	519	Alternative sequence	ID=VSP_018187;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF692	Q9BU19	175	219	97	519	Alternative sequence	ID=VSP_018187;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF692	Q9BU19	175	219	175	220	Alternative sequence	ID=VSP_018188;Note=In isoform 2. RRVGPPPETFPPPGEEEGEEEEDNDEDEEEMLSDASLWTYSSSPDD->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF521	Q96K83	13	73	1	1311	Chain	ID=PRO_0000306871;Note=Zinc finger protein 521
ZNF521	Q96K83	13	73	1	1311	Chain	ID=PRO_0000306871;Note=Zinc finger protein 521
ZNF521	Q96K83	13	73	47	67	Zinc finger	Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF521	Q96K83	13	73	47	67	Zinc finger	Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF521	Q96K83	13	73	72	73	Site	Note=Breakpoint for translocation to form PAX5-ZNF521
ZNF521	Q96K83	13	73	72	73	Site	Note=Breakpoint for translocation to form PAX5-ZNF521
ZNF485	Q8NCK3	50	82	1	441	Chain	ID=PRO_0000223953;Note=Zinc finger protein 485
ZNF485	Q8NCK3	50	82	1	441	Chain	ID=PRO_0000223953;Note=Zinc finger protein 485
ZNF485	Q8NCK3	50	82	11	82	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF485	Q8NCK3	50	82	11	82	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF485	Q8NCK3	50	82	1	91	Alternative sequence	ID=VSP_055957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF485	Q8NCK3	50	82	1	91	Alternative sequence	ID=VSP_055957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF85	Q03923	43	76	1	595	Chain	ID=PRO_0000047398;Note=Zinc finger protein 85
ZNF85	Q03923	43	76	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF85	Q03923	43	76	44	76	Alternative sequence	ID=VSP_035771;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2023909;Dbxref=PMID:2023909
ZNF85	Q03923	43	76	60	60	Natural variant	ID=VAR_033552;Note=K->T;Dbxref=dbSNP:rs7254311
ZNF792	Q3KQV3	53	94	1	632	Chain	ID=PRO_0000293698;Note=Zinc finger protein 792
ZNF792	Q3KQV3	53	94	14	85	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF227	Q86WZ6	62	90	1	799	Chain	ID=PRO_0000047468;Note=Zinc finger protein 227
ZNF227	Q86WZ6	62	90	23	94	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF334	Q9HCZ1	49	80	1	680	Chain	ID=PRO_0000047537;Note=Zinc finger protein 334
ZNF334	Q9HCZ1	49	80	10	81	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF335	Q9H4Z2	1223	1251	1	1342	Chain	ID=PRO_0000047538;Note=Zinc finger protein 335
ZNF335	Q9H4Z2	318	367	1	1342	Chain	ID=PRO_0000047538;Note=Zinc finger protein 335
ZNF335	Q9H4Z2	1223	1251	1178	1330	Compositional bias	Note=Gln-rich
ZNF711	Q9Y462	26	207	1	761	Chain	ID=PRO_0000047329;Note=Zinc finger protein 711
ZNF711	Q9Y462	26	207	1	761	Chain	ID=PRO_0000047329;Note=Zinc finger protein 711
ZNF711	Q9Y462	26	207	139	139	Natural variant	ID=VAR_062990;Note=In MRX97%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19377476;Dbxref=dbSNP:rs367654949,PMID:19377476
ZNF711	Q9Y462	26	207	139	139	Natural variant	ID=VAR_062990;Note=In MRX97%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19377476;Dbxref=dbSNP:rs367654949,PMID:19377476
ZNF620	Q6ZNG0	50	88	1	422	Chain	ID=PRO_0000047691;Note=Zinc finger protein 620
ZNF620	Q6ZNG0	50	88	11	82	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF620	Q6ZNG0	50	88	1	114	Alternative sequence	ID=VSP_016040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF532	Q9HCE3	843	901	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	956	1050	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	843	901	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	956	1050	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	843	901	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	956	1050	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	843	901	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	956	1050	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	843	901	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	956	1050	1	1301	Chain	ID=PRO_0000299552;Note=Zinc finger protein 532
ZNF532	Q9HCE3	843	901	842	865	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	842	865	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	842	865	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	842	865	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	842	865	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	870	893	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	870	893	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	870	893	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	870	893	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	843	901	870	893	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	936	959	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	936	959	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	936	959	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	936	959	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	936	959	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	1025	1048	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	1025	1048	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	1025	1048	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	1025	1048	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	1025	1048	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF532	Q9HCE3	956	1050	980	980	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF532	Q9HCE3	956	1050	980	980	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF532	Q9HCE3	956	1050	980	980	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF532	Q9HCE3	956	1050	980	980	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF532	Q9HCE3	956	1050	980	980	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF532	Q9HCE3	956	1050	972	972	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF532	Q9HCE3	956	1050	972	972	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF532	Q9HCE3	956	1050	972	972	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF532	Q9HCE3	956	1050	972	972	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF532	Q9HCE3	956	1050	972	972	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZSCAN32	Q9NX65	250	411	1	697	Chain	ID=PRO_0000047582;Note=Zinc finger and SCAN domain-containing protein 32
ZSCAN32	Q9NX65	250	411	1	697	Chain	ID=PRO_0000047582;Note=Zinc finger and SCAN domain-containing protein 32
ZSCAN32	Q9NX65	250	411	212	296	Domain	Note=KRAB
ZSCAN32	Q9NX65	250	411	212	296	Domain	Note=KRAB
ZSCAN32	Q9NX65	250	411	400	400	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZSCAN32	Q9NX65	250	411	400	400	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZSCAN32	Q9NX65	250	411	1	289	Alternative sequence	ID=VSP_055988;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZSCAN32	Q9NX65	250	411	1	289	Alternative sequence	ID=VSP_055988;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZSCAN32	Q9NX65	250	411	266	266	Natural variant	ID=VAR_052826;Note=A->V;Dbxref=dbSNP:rs17136369
ZSCAN32	Q9NX65	250	411	266	266	Natural variant	ID=VAR_052826;Note=A->V;Dbxref=dbSNP:rs17136369
ZSCAN32	Q9NX65	250	411	332	332	Natural variant	ID=VAR_024215;Note=Y->H;Dbxref=dbSNP:rs27230
ZSCAN32	Q9NX65	250	411	332	332	Natural variant	ID=VAR_024215;Note=Y->H;Dbxref=dbSNP:rs27230
ZZEF1	O43149	2547	2667	2	2961	Chain	ID=PRO_0000289000;Note=Zinc finger ZZ-type and EF-hand domain-containing protein 1
ZZEF1	O43149	1573	1627	2	2961	Chain	ID=PRO_0000289000;Note=Zinc finger ZZ-type and EF-hand domain-containing protein 1
ZZEF1	O43149	524	557	2	2961	Chain	ID=PRO_0000289000;Note=Zinc finger ZZ-type and EF-hand domain-containing protein 1
ZZEF1	O43149	166	231	2	2961	Chain	ID=PRO_0000289000;Note=Zinc finger ZZ-type and EF-hand domain-containing protein 1
ZZEF1	O43149	166	231	226	405	Domain	Note=DOC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00614
ZZEF1	O43149	2547	2667	2667	2667	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ZZEF1	O43149	1573	1627	1	1613	Alternative sequence	ID=VSP_042268;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZZEF1	O43149	524	557	1	1613	Alternative sequence	ID=VSP_042268;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZZEF1	O43149	166	231	1	1613	Alternative sequence	ID=VSP_042268;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZZEF1	O43149	2547	2667	1085	2961	Alternative sequence	ID=VSP_025871;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZZEF1	O43149	1573	1627	1085	2961	Alternative sequence	ID=VSP_025871;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZZEF1	O43149	2547	2667	2425	2961	Alternative sequence	ID=VSP_042270;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZSWIM5	Q9P217	536	585	1	1185	Chain	ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5
ZSWIM5	Q9P217	477	536	1	1185	Chain	ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5
ZSWIM5	Q9P217	417	477	1	1185	Chain	ID=PRO_0000223103;Note=Zinc finger SWIM domain-containing protein 5
ZSWIM7	Q19AV6	67	102	1	140	Chain	ID=PRO_0000307403;Note=Zinc finger SWIM domain-containing protein 7
ZSWIM7	Q19AV6	67	102	1	140	Chain	ID=PRO_0000307403;Note=Zinc finger SWIM domain-containing protein 7
ZSWIM7	Q19AV6	67	102	66	114	Zinc finger	Note=SWIM-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00325
ZSWIM7	Q19AV6	67	102	66	114	Zinc finger	Note=SWIM-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00325
YBEY	P58557	70	113	1	167	Chain	ID=PRO_0000102578;Note=Endoribonuclease YbeY
YBEY	P58557	70	113	1	167	Chain	ID=PRO_0000102578;Note=Endoribonuclease YbeY
YBEY	P58557	70	113	1	167	Chain	ID=PRO_0000102578;Note=Endoribonuclease YbeY
YBEY	P58557	70	113	26	113	Alternative sequence	ID=VSP_006722;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	26	113	Alternative sequence	ID=VSP_006722;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	26	113	Alternative sequence	ID=VSP_006722;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	26	70	Alternative sequence	ID=VSP_006721;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	26	70	Alternative sequence	ID=VSP_006721;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	26	70	Alternative sequence	ID=VSP_006721;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	71	113	Alternative sequence	ID=VSP_006723;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	71	113	Alternative sequence	ID=VSP_006723;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	71	113	Alternative sequence	ID=VSP_006723;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707072;Dbxref=PMID:11707072
YBEY	P58557	70	113	90	90	Mutagenesis	Note=No endonuclease activity. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28153719;Dbxref=PMID:28153719
YBEY	P58557	70	113	90	90	Mutagenesis	Note=No endonuclease activity. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28153719;Dbxref=PMID:28153719
YBEY	P58557	70	113	90	90	Mutagenesis	Note=No endonuclease activity. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28153719;Dbxref=PMID:28153719
YEATS2	Q9ULM3	97	179	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	217	270	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	308	323	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	383	463	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	463	517	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	552	588	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	859	912	1	1422	Chain	ID=PRO_0000076366;Note=YEATS domain-containing protein 2
YEATS2	Q9ULM3	217	270	207	317	Domain	Note=YEATS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00376
YEATS2	Q9ULM3	308	323	207	317	Domain	Note=YEATS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00376
YEATS2	Q9ULM3	217	270	259	261	Region	Note=Histone H3K27cr binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IQL,ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431
YEATS2	Q9ULM3	97	179	118	118	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
YEATS2	Q9ULM3	97	179	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TUF7
YEATS2	Q9ULM3	97	179	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YEATS2	Q9ULM3	383	463	407	407	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YEATS2	Q9ULM3	383	463	447	447	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
YEATS2	Q9ULM3	383	463	463	463	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YEATS2	Q9ULM3	463	517	463	463	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YEATS2	Q9ULM3	463	517	465	465	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
YEATS2	Q9ULM3	463	517	471	471	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YEATS2	Q9ULM3	463	517	473	473	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
YEATS2	Q9ULM3	463	517	478	478	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
YEATS2	Q9ULM3	552	588	575	575	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
YEATS2	Q9ULM3	97	179	113	113	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
YEATS2	Q9ULM3	463	517	487	487	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
YEATS2	Q9ULM3	552	588	552	552	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
YEATS2	Q9ULM3	217	270	259	259	Mutagenesis	Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431
YEATS2	Q9ULM3	217	270	261	261	Mutagenesis	Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431
YEATS2	Q9ULM3	217	270	262	262	Mutagenesis	Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431
YEATS2	Q9ULM3	308	323	313	313	Mutagenesis	Note=Reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431
YEATS2	Q9ULM3	217	270	205	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	217	270	221	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	217	270	232	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	217	270	247	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	217	270	251	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	217	270	260	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	217	270	267	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
YEATS2	Q9ULM3	308	323	314	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQL
ZNF639	Q9UID6	19	56	1	485	Chain	ID=PRO_0000047696;Note=Zinc finger protein 639
ZNF639	Q9UID6	19	56	1	485	Chain	ID=PRO_0000047696;Note=Zinc finger protein 639
ZNF639	Q9UID6	19	56	1	485	Chain	ID=PRO_0000047696;Note=Zinc finger protein 639
ZNF141	Q15928	43	75	1	474	Chain	ID=PRO_0000047424;Note=Zinc finger protein 141
ZNF141	Q15928	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF462	Q96JM2	2078	2142	1	2506	Chain	ID=PRO_0000047601;Note=Zinc finger protein 462
ZNF462	Q96JM2	2078	2142	2083	2106	Zinc finger	Note=C2H2-type 21;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF462	Q96JM2	2078	2142	2104	2104	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF410	Q86VK4	56	129	1	478	Chain	ID=PRO_0000047571;Note=Zinc finger protein 410
ZNF410	Q86VK4	334	376	1	478	Chain	ID=PRO_0000047571;Note=Zinc finger protein 410
ZNF410	Q86VK4	376	423	1	478	Chain	ID=PRO_0000047571;Note=Zinc finger protein 410
ZNF410	Q86VK4	334	376	339	362	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF410	Q86VK4	56	129	57	129	Alternative sequence	ID=VSP_042424;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF410	Q86VK4	56	129	57	57	Alternative sequence	ID=VSP_043417;Note=In isoform 5. D->EPVPWREEDGKSGCSDLN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF410	Q86VK4	334	376	273	478	Alternative sequence	ID=VSP_008486;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF410	Q86VK4	376	423	273	478	Alternative sequence	ID=VSP_008486;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF410	Q86VK4	376	423	377	423	Alternative sequence	ID=VSP_008487;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF720	Q7Z2F6	43	75	1	126	Chain	ID=PRO_0000330293;Note=Putative protein ZNF720
ZNF720	Q7Z2F6	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF720	Q7Z2F6	43	75	1	70	Alternative sequence	ID=VSP_033024;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF720	Q7Z2F6	43	75	71	74	Alternative sequence	ID=VSP_033025;Note=In isoform 2. VAIQ->MVNV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC30A7	Q8NEW0	61	98	1	376	Chain	ID=PRO_0000314299;Note=Zinc transporter 7
SLC30A7	Q8NEW0	61	98	1	376	Chain	ID=PRO_0000314299;Note=Zinc transporter 7
SLC30A7	Q8NEW0	61	98	59	67	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A7	Q8NEW0	61	98	59	67	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A7	Q8NEW0	61	98	68	88	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A7	Q8NEW0	61	98	68	88	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A7	Q8NEW0	61	98	89	102	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A7	Q8NEW0	61	98	89	102	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A7	Q8NEW0	61	98	91	91	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC30A7	Q8NEW0	61	98	91	91	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZYG11B	Q9C0D3	317	364	1	744	Chain	ID=PRO_0000305087;Note=Protein zyg-11 homolog B
ZYG11B	Q9C0D3	317	364	1	578	Alternative sequence	ID=VSP_028224;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	2	559	Chain	ID=PRO_0000223073;Note=YTH domain-containing family protein 1
YTHDF1	Q9BYJ9	44	551	389	523	Domain	Note=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
YTHDF1	Q9BYJ9	44	551	395	397	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	411	412	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	241	331	Compositional bias	Note=Gln/Pro-rich
YTHDF1	Q9BYJ9	44	551	401	401	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	441	441	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y5A9
YTHDF1	Q9BYJ9	44	551	465	465	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	470	470	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	182	182	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YTHDF1	Q9BYJ9	44	551	1	190	Alternative sequence	ID=VSP_006815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	191	260	Alternative sequence	ID=VSP_006816;Note=In isoform 2. KIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGL->MLFLGSLGAWGTTSISTGSIFSLKTLRSQHGGQVGLKVSRPRAPRMGAATPTPRAPWVARWLMGSQAFTATPSAR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	383	559	Alternative sequence	ID=VSP_006817;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	397	397	Mutagenesis	Note=Strongly reduced binding to N6-methyladenosine (m6A)-containing RNAs. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	401	401	Mutagenesis	Note=Increased binding to N6-methyladenosine (m6A)-containing RNAs. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	411	411	Mutagenesis	Note=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	465	465	Mutagenesis	Note=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	470	470	Mutagenesis	Note=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	506	506	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	123	124	Sequence conflict	Note=FP->AR;Ontology_term=ECO:0000305;evidence=ECO:0000305
YTHDF1	Q9BYJ9	44	551	283	284	Sequence conflict	Note=AP->PH;Ontology_term=ECO:0000305;evidence=ECO:0000305
YTHDF1	Q9BYJ9	44	551	366	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	390	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	399	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	415	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	434	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	443	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	457	459	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	465	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	473	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	486	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	489	491	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	495	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	502	504	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	513	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	532	535	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	536	550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
ZNF280C	Q8ND82	416	465	1	737	Chain	ID=PRO_0000227975;Note=Zinc finger protein 280C
ZNF280C	Q8ND82	416	465	413	436	Zinc finger	Note=C2H2-type 4
ZBTB11	O95625	600	682	1	1053	Chain	ID=PRO_0000047727;Note=Zinc finger and BTB domain-containing protein 11
ZBTB11	O95625	600	682	597	619	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB11	O95625	600	682	651	673	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB11	O95625	600	682	679	701	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZC3H8	Q8N5P1	168	207	1	291	Chain	ID=PRO_0000213903;Note=Zinc finger CCCH domain-containing protein 8
ZC3H8	Q8N5P1	168	207	1	291	Chain	ID=PRO_0000213903;Note=Zinc finger CCCH domain-containing protein 8
ZC3H8	Q8N5P1	168	207	191	218	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H8	Q8N5P1	168	207	191	218	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZEB2	O60315	134	197	1	1214	Chain	ID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
ZEB2	O60315	110	134	1	1214	Chain	ID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
ZEB2	O60315	134	197	1	1214	Chain	ID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
ZEB2	O60315	110	134	1	1214	Chain	ID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
ZEB2	O60315	134	197	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZEB2	O60315	134	197	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZEB2	O60315	134	197	111	134	Alternative sequence	ID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZEB2	O60315	110	134	111	134	Alternative sequence	ID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZEB2	O60315	134	197	111	134	Alternative sequence	ID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZEB2	O60315	110	134	111	134	Alternative sequence	ID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFHX2	Q9C0A1	933	958	1	2572	Chain	ID=PRO_0000047243;Note=Zinc finger homeobox protein 2
ZFHX2	Q9C0A1	933	958	863	2572	Alternative sequence	ID=VSP_039497;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214970;Dbxref=PMID:11214970
ZFHX3	Q15911	1322	3142	1	3703	Chain	ID=PRO_0000046930;Note=Zinc finger homeobox protein 3
ZFHX3	Q15911	1221	1288	1	3703	Chain	ID=PRO_0000046930;Note=Zinc finger homeobox protein 3
ZFHX3	Q15911	1221	1288	1223	1246	Zinc finger	Note=C2H2-type 11%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1221	1288	1252	1275	Zinc finger	Note=C2H2-type 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	1360	1385	Zinc finger	Note=C2H2-type 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	1401	1423	Zinc finger	Note=C2H2-type 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	1429	1452	Zinc finger	Note=C2H2-type 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	1545	1569	Zinc finger	Note=C2H2-type 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	1596	1620	Zinc finger	Note=C2H2-type 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	1983	2006	Zinc finger	Note=C2H2-type 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	2145	2204	DNA binding	Note=Homeobox 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
ZFHX3	Q15911	1322	3142	2242	2301	DNA binding	Note=Homeobox 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
ZFHX3	Q15911	1322	3142	2328	2351	Zinc finger	Note=C2H2-type 19%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	2530	2552	Zinc finger	Note=C2H2-type 20;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	2641	2700	DNA binding	Note=Homeobox 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
ZFHX3	Q15911	1322	3142	2711	2734	Zinc finger	Note=C2H2-type 21;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	2944	3003	DNA binding	Note=Homeobox 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
ZFHX3	Q15911	1322	3142	3024	3048	Zinc finger	Note=C2H2-type 22;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFHX3	Q15911	1322	3142	2615	2617	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24651376;Dbxref=PMID:24651376
ZFHX3	Q15911	1322	3142	1723	1743	Compositional bias	Note=Poly-Gln
ZFHX3	Q15911	1322	3142	1789	1794	Compositional bias	Note=Poly-Gln
ZFHX3	Q15911	1322	3142	1852	1857	Compositional bias	Note=Poly-Gln
ZFHX3	Q15911	1322	3142	2037	2052	Compositional bias	Note=Poly-Pro
ZFHX3	Q15911	1322	3142	1590	1590	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61329
ZFHX3	Q15911	1322	3142	2625	2625	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61329
ZFHX3	Q15911	1322	3142	2786	2786	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61329
ZFHX3	Q15911	1322	3142	2795	2795	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZFHX3	Q15911	1322	3142	2892	2892	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61329
ZFHX3	Q15911	1322	3142	2896	2896	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZFHX3	Q15911	1322	3142	2349	2349	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24651376;Dbxref=PMID:24651376
ZFHX3	Q15911	1322	3142	2806	2806	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24651376;Dbxref=PMID:24651376
ZFHX3	Q15911	1322	3142	2806	2806	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZFHX3	Q15911	1322	3142	2349	2349	Mutagenesis	Note=Loss of sumoylation. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24651376;Dbxref=PMID:24651376
ZFHX3	Q15911	1322	3142	2615	2617	Mutagenesis	Note=Loss of nuclear localization. KRK->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24651376;Dbxref=PMID:24651376
ZFHX3	Q15911	1322	3142	2806	2806	Mutagenesis	Note=Loss of sumoylation. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24651376;Dbxref=PMID:24651376
ZFHX3	Q15911	1322	3142	2154	2166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA1
ZFHX3	Q15911	1322	3142	2174	2182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA1
ZFHX3	Q15911	1322	3142	2186	2201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA1
ZFHX3	Q15911	1322	3142	2251	2263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA2
ZFHX3	Q15911	1322	3142	2269	2278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA2
ZFHX3	Q15911	1322	3142	2283	2297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA2
ZFHX3	Q15911	1322	3142	2650	2652	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA3
ZFHX3	Q15911	1322	3142	2653	2662	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA3
ZFHX3	Q15911	1322	3142	2668	2678	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA3
ZFHX3	Q15911	1322	3142	2682	2697	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DA3
ZER1	Q7Z7L7	618	680	2	766	Chain	ID=PRO_0000066598;Note=Protein zer-1 homolog
ZER1	Q7Z7L7	525	539	2	766	Chain	ID=PRO_0000066598;Note=Protein zer-1 homolog
ZER1	Q7Z7L7	346	395	2	766	Chain	ID=PRO_0000066598;Note=Protein zer-1 homolog
ZER1	Q7Z7L7	249	307	2	766	Chain	ID=PRO_0000066598;Note=Protein zer-1 homolog
ZER1	Q7Z7L7	249	307	246	268	Repeat	Note=LRR 2
ZER1	Q7Z7L7	249	307	278	302	Repeat	Note=LRR 3
ZER1	Q7Z7L7	525	539	511	556	Repeat	Note=ARM 2
ZER1	Q7Z7L7	618	680	602	643	Repeat	Note=ARM 4
ZER1	Q7Z7L7	525	539	539	539	Natural variant	ID=VAR_060159;Note=T->I;Dbxref=dbSNP:rs13299702
ZER1	Q7Z7L7	249	307	249	249	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZER1	Q7Z7L7	618	680	653	653	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFP69	Q49AA0	115	147	1	526	Chain	ID=PRO_0000252161;Note=Zinc finger protein 69 homolog
ZFP69	Q49AA0	115	147	1	526	Chain	ID=PRO_0000252161;Note=Zinc finger protein 69 homolog
ZFP69	Q49AA0	115	147	76	147	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZFP69	Q49AA0	115	147	76	147	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZFAND2B	Q8WV99	50	94	1	254	Chain	ID=PRO_0000232876;Note=AN1-type zinc finger protein 2B
ZFAND2B	Q8WV99	145	175	1	254	Chain	ID=PRO_0000232876;Note=AN1-type zinc finger protein 2B
ZFAND2B	Q8WV99	50	94	1	254	Chain	ID=PRO_0000232876;Note=AN1-type zinc finger protein 2B
ZFAND2B	Q8WV99	145	175	1	254	Chain	ID=PRO_0000232876;Note=AN1-type zinc finger protein 2B
ZFAND2B	Q8WV99	50	94	1	254	Chain	ID=PRO_0000232876;Note=AN1-type zinc finger protein 2B
ZFAND2B	Q8WV99	145	175	1	254	Chain	ID=PRO_0000232876;Note=AN1-type zinc finger protein 2B
ZFAND2B	Q8WV99	50	94	7	52	Zinc finger	Note=AN1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2B	Q8WV99	50	94	7	52	Zinc finger	Note=AN1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2B	Q8WV99	50	94	7	52	Zinc finger	Note=AN1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2B	Q8WV99	145	175	97	145	Zinc finger	Note=AN1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2B	Q8WV99	145	175	97	145	Zinc finger	Note=AN1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2B	Q8WV99	145	175	97	145	Zinc finger	Note=AN1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2B	Q8WV99	145	175	141	151	Region	Note=VCP/p97-interacting motif (VIM);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21896481;Dbxref=PMID:21896481
ZFAND2B	Q8WV99	145	175	141	151	Region	Note=VCP/p97-interacting motif (VIM);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21896481;Dbxref=PMID:21896481
ZFAND2B	Q8WV99	145	175	141	151	Region	Note=VCP/p97-interacting motif (VIM);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21896481;Dbxref=PMID:21896481
ZFAND2B	Q8WV99	145	175	163	163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91X58
ZFAND2B	Q8WV99	145	175	163	163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91X58
ZFAND2B	Q8WV99	145	175	163	163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91X58
ZFAND2B	Q8WV99	145	175	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91X58
ZFAND2B	Q8WV99	145	175	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91X58
ZFAND2B	Q8WV99	145	175	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91X58
ZFP64	Q9NTW7	95	149	1	645	Chain	ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4
ZFP64	Q9NTW7	170	254	1	645	Chain	ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4
ZFP64	Q9NTW7	95	149	1	645	Chain	ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4
ZFP64	Q9NTW7	170	254	175	197	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFP64	Q9NTW7	170	254	203	225	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFP64	Q9NTW7	170	254	231	253	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFP64	Q9NTW7	95	149	1	219	Alternative sequence	ID=VSP_007285;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFP64	Q9NTW7	170	254	1	219	Alternative sequence	ID=VSP_007285;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFP64	Q9NTW7	95	149	1	219	Alternative sequence	ID=VSP_007285;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFP64	Q9NTW7	170	254	220	254	Alternative sequence	ID=VSP_007286;Note=In isoform 4. KHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHT->MSRRKQAKPQHLNSEEPRPARRECAEVAPQVAGEP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFP64	Q9NTW7	170	254	236	390	Alternative sequence	ID=VSP_046897;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFP64	Q9NTW7	170	254	240	240	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND4	Q86XD8	239	624	1	727	Chain	ID=PRO_0000269892;Note=AN1-type zinc finger protein 4
ZFAND4	Q86XD8	239	624	358	358	Natural variant	ID=VAR_053774;Note=H->Y;Dbxref=dbSNP:rs12267385
ZFAND4	Q86XD8	239	624	523	523	Natural variant	ID=VAR_062163;Note=T->A;Dbxref=dbSNP:rs34082391
ZIK1	Q3SY52	11	24	1	487	Chain	ID=PRO_0000286793;Note=Zinc finger protein interacting with ribonucleoprotein K
ZIK1	Q3SY52	11	24	1	103	Alternative sequence	ID=VSP_025148;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZIK1	Q3SY52	11	24	1	55	Alternative sequence	ID=VSP_025147;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZMYND19	Q96E35	73	119	1	227	Chain	ID=PRO_0000218319;Note=Zinc finger MYND domain-containing protein 19
ZMYM1	Q5SVZ6	320	367	1	1142	Chain	ID=PRO_0000191377;Note=Zinc finger MYM-type protein 1
ZMYM1	Q5SVZ6	320	367	1	1142	Chain	ID=PRO_0000191377;Note=Zinc finger MYM-type protein 1
ZMYM1	Q5SVZ6	320	367	300	331	Zinc finger	Note=MYM-type 4
ZMYM1	Q5SVZ6	320	367	300	331	Zinc finger	Note=MYM-type 4
ZNF234	Q14588	47	78	1	700	Chain	ID=PRO_0000047473;Note=Zinc finger protein 234
ZNF234	Q14588	47	78	1	700	Chain	ID=PRO_0000047473;Note=Zinc finger protein 234
ZNF234	Q14588	47	78	8	90	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF234	Q14588	47	78	8	90	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF506	Q5JVG8	43	75	1	444	Chain	ID=PRO_0000047624;Note=Zinc finger protein 506
ZNF506	Q5JVG8	43	75	1	444	Chain	ID=PRO_0000047624;Note=Zinc finger protein 506
ZNF506	Q5JVG8	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF506	Q5JVG8	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF506	Q5JVG8	43	75	44	75	Alternative sequence	ID=VSP_040653;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF506	Q5JVG8	43	75	44	75	Alternative sequence	ID=VSP_040653;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF398	Q8TD17	8	140	1	642	Chain	ID=PRO_0000047565;Note=Zinc finger protein 398
ZNF398	Q8TD17	220	258	1	642	Chain	ID=PRO_0000047565;Note=Zinc finger protein 398
ZNF398	Q8TD17	8	140	1	171	Alternative sequence	ID=VSP_006926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11779858,ECO:0000303|PubMed:14702039;Dbxref=PMID:11779858,PMID:14702039
ZNF398	Q8TD17	8	140	87	87	Natural variant	ID=VAR_052817;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3801979,PMID:14702039
ZNF407	Q9C0G0	1601	1625	1	2248	Chain	ID=PRO_0000047568;Note=Zinc finger protein 407
ZNF407	Q9C0G0	1601	1625	1595	1618	Zinc finger	Note=C2H2-type 16;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF407	Q9C0G0	1601	1625	1625	1660	Alternative sequence	ID=VSP_028843;Note=In isoform 3. ERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTW->ERVKVAYRKIGTLPGIQNNRNASSASEAQSLCEHFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF75A	Q96N20	33	70	1	296	Chain	ID=PRO_0000047385;Note=Zinc finger protein 75A
ZNF75A	Q96N20	33	70	1	66	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF480	Q8WV37	66	109	1	535	Chain	ID=PRO_0000047607;Note=Zinc finger protein 480
ZNF480	Q8WV37	66	109	27	98	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF480	Q8WV37	66	109	1	169	Alternative sequence	ID=VSP_016215;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF480	Q8WV37	66	109	1	77	Alternative sequence	ID=VSP_016214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF217	O75362	455	494	1	1048	Chain	ID=PRO_0000047460;Note=Zinc finger protein 217
ZNF217	O75362	455	494	1	1048	Chain	ID=PRO_0000047460;Note=Zinc finger protein 217
ZNF217	O75362	455	494	471	493	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF217	O75362	455	494	471	493	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF217	O75362	455	494	474	476	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UK3
ZNF217	O75362	455	494	474	476	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UK3
ZNF217	O75362	455	494	483	494	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UK3
ZNF217	O75362	455	494	483	494	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UK3
ZNF90	Q03938	43	75	1	601	Chain	ID=PRO_0000047399;Note=Zinc finger protein 90
ZNF90	Q03938	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
SLC7A7	Q9UM01	365	415	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	166	208	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	365	415	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	166	208	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	365	415	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	166	208	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	365	415	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	166	208	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	365	415	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	166	208	1	511	Chain	ID=PRO_0000054281;Note=Y+L amino acid transporter 1
SLC7A7	Q9UM01	166	208	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	365	415	383	403	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	365	415	383	403	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	365	415	383	403	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	365	415	383	403	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	365	415	383	403	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A7	Q9UM01	166	208	188	188	Natural variant	ID=VAR_030596;Note=In LPI%3B failed to induce cationic amino acid transport activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833819,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	166	208	188	188	Natural variant	ID=VAR_030596;Note=In LPI%3B failed to induce cationic amino acid transport activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833819,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	166	208	188	188	Natural variant	ID=VAR_030596;Note=In LPI%3B failed to induce cationic amino acid transport activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833819,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	166	208	188	188	Natural variant	ID=VAR_030596;Note=In LPI%3B failed to induce cationic amino acid transport activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833819,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	166	208	188	188	Natural variant	ID=VAR_030596;Note=In LPI%3B failed to induce cationic amino acid transport activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833819,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	166	208	191	191	Natural variant	ID=VAR_039100;Note=In LPI. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833820,PMID:17764084
SLC7A7	Q9UM01	166	208	191	191	Natural variant	ID=VAR_039100;Note=In LPI. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833820,PMID:17764084
SLC7A7	Q9UM01	166	208	191	191	Natural variant	ID=VAR_039100;Note=In LPI. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833820,PMID:17764084
SLC7A7	Q9UM01	166	208	191	191	Natural variant	ID=VAR_039100;Note=In LPI. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833820,PMID:17764084
SLC7A7	Q9UM01	166	208	191	191	Natural variant	ID=VAR_039100;Note=In LPI. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833820,PMID:17764084
SLC7A7	Q9UM01	365	415	365	365	Natural variant	ID=VAR_039103;Note=In LPI. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833797,PMID:17764084
SLC7A7	Q9UM01	365	415	365	365	Natural variant	ID=VAR_039103;Note=In LPI. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833797,PMID:17764084
SLC7A7	Q9UM01	365	415	365	365	Natural variant	ID=VAR_039103;Note=In LPI. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833797,PMID:17764084
SLC7A7	Q9UM01	365	415	365	365	Natural variant	ID=VAR_039103;Note=In LPI. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833797,PMID:17764084
SLC7A7	Q9UM01	365	415	365	365	Natural variant	ID=VAR_039103;Note=In LPI. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833797,PMID:17764084
SLC7A7	Q9UM01	365	415	386	386	Natural variant	ID=VAR_011000;Note=In LPI%3B failed to induce cationic amino acid transport activity. S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10631139,ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833799,PMID:10631139,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	365	415	386	386	Natural variant	ID=VAR_011000;Note=In LPI%3B failed to induce cationic amino acid transport activity. S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10631139,ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833799,PMID:10631139,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	365	415	386	386	Natural variant	ID=VAR_011000;Note=In LPI%3B failed to induce cationic amino acid transport activity. S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10631139,ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833799,PMID:10631139,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	365	415	386	386	Natural variant	ID=VAR_011000;Note=In LPI%3B failed to induce cationic amino acid transport activity. S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10631139,ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833799,PMID:10631139,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	365	415	386	386	Natural variant	ID=VAR_011000;Note=In LPI%3B failed to induce cationic amino acid transport activity. S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10631139,ECO:0000269|PubMed:15776427,ECO:0000269|PubMed:17764084;Dbxref=dbSNP:rs386833799,PMID:10631139,PMID:15776427,PMID:17764084
SLC7A7	Q9UM01	365	415	413	413	Natural variant	ID=VAR_036609;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SLC7A7	Q9UM01	365	415	413	413	Natural variant	ID=VAR_036609;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SLC7A7	Q9UM01	365	415	413	413	Natural variant	ID=VAR_036609;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SLC7A7	Q9UM01	365	415	413	413	Natural variant	ID=VAR_036609;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SLC7A7	Q9UM01	365	415	413	413	Natural variant	ID=VAR_036609;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ZNF318	Q5VUA4	1024	1092	1	2279	Chain	ID=PRO_0000191807;Note=Zinc finger protein 318
ZNF318	Q5VUA4	1024	1092	1063	1097	Zinc finger	Note=Matrin-type 1
ZNF318	Q5VUA4	1024	1092	1	1092	Region	Note=Interaction with AR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99PP2
ZNF318	Q5VUA4	1024	1092	1037	1037	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
ZNF318	Q5VUA4	1024	1092	1034	1035	Sequence conflict	Note=RT->CI;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF318	Q5VUA4	1024	1092	1034	1035	Sequence conflict	Note=RT->CI;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF273	Q14593	76	108	1	569	Chain	ID=PRO_0000047500;Note=Zinc finger protein 273
ZNF273	Q14593	11	43	1	569	Chain	ID=PRO_0000047500;Note=Zinc finger protein 273
ZNF273	Q14593	76	108	66	108	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF273	Q14593	11	43	1	65	Alternative sequence	ID=VSP_038180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZNF573	Q86YE8	67	98	1	665	Chain	ID=PRO_0000274877;Note=Zinc finger protein 573
ZNF573	Q86YE8	67	98	28	100	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF573	Q86YE8	67	98	1	97	Alternative sequence	ID=VSP_022894;Note=In isoform 3. MFPVLEPHQVGLIRSYNSKTMTCFQELVTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLGGHSISKPVVVDLLERGKEPWMILREETQF->MESCSVAQAGVQWPDLSSLQPPPPRFKQFSCHSLQVAGI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF573	Q86YE8	67	98	1	88	Alternative sequence	ID=VSP_022895;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF573	Q86YE8	67	98	68	98	Alternative sequence	ID=VSP_022897;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF624	Q9P2J8	29	51	1	865	Chain	ID=PRO_0000047695;Note=Zinc finger protein 624
ZNF624	Q9P2J8	29	51	1	126	Alternative sequence	ID=VSP_037538;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15489334;Dbxref=PMID:10718198,PMID:15489334
ZNRF3	Q9ULT6	142	167	56	936	Chain	ID=PRO_0000277806;Note=E3 ubiquitin-protein ligase ZNRF3
ZNRF3	Q9ULT6	211	248	56	936	Chain	ID=PRO_0000277806;Note=E3 ubiquitin-protein ligase ZNRF3
ZNRF3	Q9ULT6	248	304	56	936	Chain	ID=PRO_0000277806;Note=E3 ubiquitin-protein ligase ZNRF3
ZNRF3	Q9ULT6	142	167	56	219	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNRF3	Q9ULT6	211	248	56	219	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNRF3	Q9ULT6	211	248	220	240	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNRF3	Q9ULT6	211	248	241	936	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNRF3	Q9ULT6	248	304	241	936	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNRF3	Q9ULT6	248	304	293	334	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
ZYG11A	Q6WRX3	383	442	1	759	Chain	ID=PRO_0000305085;Note=Protein zyg-11 homolog A
ZYG11A	Q6WRX3	568	583	1	759	Chain	ID=PRO_0000305085;Note=Protein zyg-11 homolog A
ZYG11A	Q6WRX3	583	648	1	759	Chain	ID=PRO_0000305085;Note=Protein zyg-11 homolog A
ZWINT	O95229	141	160	1	277	Chain	ID=PRO_0000066594;Note=ZW10 interactor
ZWINT	O95229	141	160	1	277	Chain	ID=PRO_0000066594;Note=ZW10 interactor
ZWINT	O95229	141	160	80	155	Region	Note=Interaction with NDC80 and ZW10
ZWINT	O95229	141	160	80	155	Region	Note=Interaction with NDC80 and ZW10
ZWINT	O95229	141	160	104	217	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZWINT	O95229	141	160	104	217	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZSWIM4	Q9H7M6	337	393	1	989	Chain	ID=PRO_0000223101;Note=Zinc finger SWIM domain-containing protein 4
ZNF385D	Q9H6B1	55	92	1	395	Chain	ID=PRO_0000191819;Note=Zinc finger protein 385D
ZNF385D	Q9H6B1	55	92	80	110	Zinc finger	Note=Matrin-type 1
ZBTB10	Q96DT7	620	653	1	871	Chain	ID=PRO_0000047725;Note=Zinc finger and BTB domain-containing protein 10
ZBTB10	Q96DT7	620	653	1	871	Chain	ID=PRO_0000047725;Note=Zinc finger and BTB domain-containing protein 10
ZC3H6	P61129	617	695	1	1189	Chain	ID=PRO_0000213901;Note=Zinc finger CCCH domain-containing protein 6
ZC3H6	P61129	617	695	1	1189	Chain	ID=PRO_0000213901;Note=Zinc finger CCCH domain-containing protein 6
ZDHHC11	Q9H8X9	209	261	1	412	Chain	ID=PRO_0000212883;Note=Probable palmitoyltransferase ZDHHC11
ZDHHC11	Q9H8X9	209	261	231	251	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC11	Q9H8X9	209	261	1	213	Alternative sequence	ID=VSP_055997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ZBTB32	Q9Y2Y4	318	341	1	487	Chain	ID=PRO_0000273417;Note=Zinc finger and BTB domain-containing protein 32
ZBTB32	Q9Y2Y4	318	341	1	487	Chain	ID=PRO_0000273417;Note=Zinc finger and BTB domain-containing protein 32
ZDHHC2	Q9UIJ5	148	158	1	367	Chain	ID=PRO_0000212859;Note=Palmitoyltransferase ZDHHC2
ZDHHC2	Q9UIJ5	286	316	1	367	Chain	ID=PRO_0000212859;Note=Palmitoyltransferase ZDHHC2
ZDHHC2	Q9UIJ5	148	158	127	177	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC2	Q9UIJ5	286	316	306	306	Natural variant	ID=VAR_015229;Note=In a hepatocellular carcinoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10918388;Dbxref=PMID:10918388
ZCWPW1	Q9H0M4	490	541	1	648	Chain	ID=PRO_0000066567;Note=Zinc finger CW-type PWWP domain protein 1
ZCWPW1	Q9H0M4	390	417	1	648	Chain	ID=PRO_0000066567;Note=Zinc finger CW-type PWWP domain protein 1
ZCWPW1	Q9H0M4	490	541	467	648	Alternative sequence	ID=VSP_035590;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZCWPW1	Q9H0M4	490	541	471	523	Alternative sequence	ID=VSP_011436;Note=In isoform 3 and isoform 5. DPILPIRKRVKIQTQKTKPRGLGGDAGTADGRGRTLQRKIMKRSLGRKSTAPP->ALRKNLKLPRARPWQPAFQREKKLEQCQRTWAYQRVRGPAPHLRKKSPDTGNP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZCWPW1	Q9H0M4	490	541	491	541	Alternative sequence	ID=VSP_035591;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZCWPW1	Q9H0M4	490	541	524	648	Alternative sequence	ID=VSP_035592;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFAND2A	Q8N6M9	50	94	1	145	Chain	ID=PRO_0000269888;Note=AN1-type zinc finger protein 2A
ZFAND2A	Q8N6M9	50	94	7	52	Zinc finger	Note=AN1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND2A	Q8N6M9	50	94	53	53	Natural variant	ID=VAR_055295;Note=H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855544,PMID:15489334
ZFX	P17010	19	215	1	805	Chain	ID=PRO_0000047258;Note=Zinc finger X-chromosomal protein
ZFX	P17010	313	364	1	805	Chain	ID=PRO_0000047258;Note=Zinc finger X-chromosomal protein
ZFX	P17010	364	411	1	805	Chain	ID=PRO_0000047258;Note=Zinc finger X-chromosomal protein
ZFX	P17010	19	215	1	805	Chain	ID=PRO_0000047258;Note=Zinc finger X-chromosomal protein
ZFX	P17010	313	364	1	805	Chain	ID=PRO_0000047258;Note=Zinc finger X-chromosomal protein
ZFX	P17010	364	411	1	805	Chain	ID=PRO_0000047258;Note=Zinc finger X-chromosomal protein
ZFX	P17010	19	215	1	229	Alternative sequence	ID=VSP_014371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2512506;Dbxref=PMID:2512506
ZFX	P17010	19	215	1	229	Alternative sequence	ID=VSP_014371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2512506;Dbxref=PMID:2512506
ZFX	P17010	19	215	19	19	Alternative sequence	ID=VSP_054512;Note=In isoform 3. T->TDRVSFCHPGWSTVAPSGSTATSASQAQVICSASRVTGAT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFX	P17010	19	215	19	19	Alternative sequence	ID=VSP_054512;Note=In isoform 3. T->TDRVSFCHPGWSTVAPSGSTATSASQAQVICSASRVTGAT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFX	P17010	313	364	337	341	Sequence conflict	Note=AAAAA->GHAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFX	P17010	313	364	337	341	Sequence conflict	Note=AAAAA->GHAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFX	P17010	313	364	337	341	Sequence conflict	Note=AAAAA->GHAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFX	P17010	313	364	337	341	Sequence conflict	Note=AAAAA->GHAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFX	P17010	313	364	337	337	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFX	P17010	313	364	337	337	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFP37	Q9Y6Q3	71	116	1	630	Chain	ID=PRO_0000047293;Note=Zinc finger protein 37 homolog
ZFP37	Q9Y6Q3	71	116	32	103	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF431	Q8TF32	1	32	1	576	Chain	ID=PRO_0000047579;Note=Zinc finger protein 431
ZNF431	Q8TF32	1	32	3	3	Natural variant	ID=VAR_052825;Note=D->G;Dbxref=dbSNP:rs17445374
ZNF263	O14978	256	295	1	683	Chain	ID=PRO_0000047491;Note=Zinc finger protein 263
ZNF263	O14978	256	295	217	289	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF263	O14978	256	295	285	285	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF330	Q9Y3S2	139	174	1	320	Chain	ID=PRO_0000066590;Note=Zinc finger protein 330
ZNF330	Q9Y3S2	139	174	129	149	Zinc finger	Note=C4-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNF267	Q14586	43	75	1	743	Chain	ID=PRO_0000047494;Note=Zinc finger protein 267
ZNF267	Q14586	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF267	Q14586	43	75	66	66	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
ZNF268	Q14587	11	78	1	947	Chain	ID=PRO_0000047495;Note=Zinc finger protein 268
ZNF268	Q14587	11	78	1	947	Chain	ID=PRO_0000047495;Note=Zinc finger protein 268
ZNF268	Q14587	11	78	1	161	Alternative sequence	ID=VSP_006909;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11311945,ECO:0000303|PubMed:12200376;Dbxref=PMID:11311945,PMID:12200376
ZNF268	Q14587	11	78	1	161	Alternative sequence	ID=VSP_006909;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11311945,ECO:0000303|PubMed:12200376;Dbxref=PMID:11311945,PMID:12200376
ZNF268	Q14587	11	78	1	140	Alternative sequence	ID=VSP_053461;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	1	140	Alternative sequence	ID=VSP_053461;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	12	99	Alternative sequence	ID=VSP_053462;Note=In isoform 4. VPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLD->GTNTPNLISSSSWNKEKSCVWCRPKFQIRPVQTQSGKLMILWIGIRKIKTSWEVWQKALNALHLENYVFLVQSIFQDKNLINVARMERV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	12	99	Alternative sequence	ID=VSP_053462;Note=In isoform 4. VPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLD->GTNTPNLISSSSWNKEKSCVWCRPKFQIRPVQTQSGKLMILWIGIRKIKTSWEVWQKALNALHLENYVFLVQSIFQDKNLINVARMERV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	12	78	Alternative sequence	ID=VSP_053463;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	12	78	Alternative sequence	ID=VSP_053463;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	12	44	Alternative sequence	ID=VSP_053464;Note=In isoform 6. VPPLQERNSSWDRIRKLQGQESILGQGTPGLQP->GTNTPNLISSSSWNKEKSCVWCRPKFQIRPVQF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	12	44	Alternative sequence	ID=VSP_053464;Note=In isoform 6. VPPLQERNSSWDRIRKLQGQESILGQGTPGLQP->GTNTPNLISSSSWNKEKSCVWCRPKFQIRPVQF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	45	947	Alternative sequence	ID=VSP_053465;Note=In isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF268	Q14587	11	78	45	947	Alternative sequence	ID=VSP_053465;Note=In isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16865230,ECO:0000303|PubMed:18949428;Dbxref=PMID:16865230,PMID:18949428
ZNF805	Q5CZA5	52	84	1	627	Chain	ID=PRO_0000304624;Note=Zinc finger protein 805
ZNF805	Q5CZA5	52	84	13	84	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF805	Q5CZA5	52	84	1	133	Alternative sequence	ID=VSP_040823;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF805	Q5CZA5	52	84	68	68	Natural variant	ID=VAR_057454;Note=G->E;Dbxref=dbSNP:rs2014572
ZNF527	Q8NB42	53	85	1	609	Chain	ID=PRO_0000047639;Note=Zinc finger protein 527
ZNF527	Q8NB42	53	85	14	123	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF527	Q8NB42	53	85	54	85	Alternative sequence	ID=VSP_040341;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF527	Q8NB42	53	85	57	57	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF527	Q8NB42	53	85	57	57	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF205	O95201	161	198	1	554	Chain	ID=PRO_0000047451;Note=Zinc finger protein 205
ZNF205	O95201	161	198	1	554	Chain	ID=PRO_0000047451;Note=Zinc finger protein 205
ZNF205	O95201	161	198	124	193	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF205	O95201	161	198	124	193	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF850	A8MQ14	46	78	1	1090	Chain	ID=PRO_0000332269;Note=Zinc finger protein 850
ZNF850	A8MQ14	46	78	7	78	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF34	Q8IZ26	74	114	1	560	Chain	ID=PRO_0000047365;Note=Zinc finger protein 34
ZNF34	Q8IZ26	74	114	35	108	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF34	Q8IZ26	74	114	113	113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SLC30A4	O14863	130	179	1	429	Chain	ID=PRO_0000206099;Note=Zinc transporter 4
SLC30A4	O14863	130	179	114	134	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A4	O14863	130	179	135	143	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A4	O14863	130	179	144	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A4	O14863	130	179	165	178	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A4	O14863	130	179	179	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNF44	P15621	1	49	1	663	Chain	ID=PRO_0000047377;Note=Zinc finger protein 44
ZNF44	P15621	1	49	1	48	Alternative sequence	ID=VSP_035757;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ZNF44	P15621	1	49	49	49	Alternative sequence	ID=VSP_035758;Note=In isoform 2. Q->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ZDHHC21	Q8IVQ6	168	207	1	265	Chain	ID=PRO_0000212908;Note=Palmitoyltransferase ZDHHC21
ZDHHC21	Q8IVQ6	168	207	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC1	Q8WTX9	218	271	1	485	Chain	ID=PRO_0000212857;Note=Probable palmitoyltransferase ZDHHC1
ZDHHC1	Q8WTX9	143	176	1	485	Chain	ID=PRO_0000212857;Note=Probable palmitoyltransferase ZDHHC1
ZDHHC1	Q8WTX9	218	271	242	262	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC1	Q8WTX9	143	176	134	184	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC17	Q8IUH5	107	132	1	632	Chain	ID=PRO_0000212900;Note=Palmitoyltransferase ZDHHC17
ZDHHC17	Q8IUH5	257	299	1	632	Chain	ID=PRO_0000212900;Note=Palmitoyltransferase ZDHHC17
ZDHHC17	Q8IUH5	422	443	1	632	Chain	ID=PRO_0000212900;Note=Palmitoyltransferase ZDHHC17
ZDHHC17	Q8IUH5	107	132	1	304	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC17	Q8IUH5	257	299	1	304	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC17	Q8IUH5	422	443	403	480	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC17	Q8IUH5	107	132	89	118	Repeat	Note=ANK 2;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255,ECO:0000305|PubMed:28757145;Dbxref=PMID:28757145
ZDHHC17	Q8IUH5	107	132	123	152	Repeat	Note=ANK 3;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255,ECO:0000305|PubMed:28757145;Dbxref=PMID:28757145
ZDHHC17	Q8IUH5	257	299	257	286	Repeat	Note=ANK 7;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255,ECO:0000305|PubMed:28757145;Dbxref=PMID:28757145
ZDHHC17	Q8IUH5	422	443	437	487	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC17	Q8IUH5	107	132	11	305	Region	Note=Necessary and sufficient for interaction with DNAJC5 and SNAP25;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80TN5
ZDHHC17	Q8IUH5	257	299	11	305	Region	Note=Necessary and sufficient for interaction with DNAJC5 and SNAP25;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80TN5
ZDHHC17	Q8IUH5	257	299	204	632	Alternative sequence	ID=VSP_010023;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
ZDHHC17	Q8IUH5	422	443	204	632	Alternative sequence	ID=VSP_010023;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
ZDHHC17	Q8IUH5	257	299	258	266	Alternative sequence	ID=VSP_010024;Note=In isoform 2. GESALDLAK->AILRCHMAL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZDHHC17	Q8IUH5	257	299	267	632	Alternative sequence	ID=VSP_010025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZDHHC17	Q8IUH5	422	443	267	632	Alternative sequence	ID=VSP_010025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZDHHC17	Q8IUH5	107	132	122	122	Mutagenesis	Note=Mildly decreased binding affinity for SNAP25. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28757145;Dbxref=PMID:28757145
ZDHHC17	Q8IUH5	107	132	130	130	Mutagenesis	Note=Abolishes SNAP25 and HTT binding. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28757145;Dbxref=PMID:28757145
ZDHHC17	Q8IUH5	107	132	103	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU9
ZDHHC17	Q8IUH5	107	132	121	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU9
ZDHHC17	Q8IUH5	107	132	127	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU9
ZDHHC17	Q8IUH5	257	299	261	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU9
ZDHHC17	Q8IUH5	257	299	271	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU9
ZDHHC6	Q9H6R6	301	315	1	413	Chain	ID=PRO_0000212871;Note=Palmitoyltransferase ZDHHC6
ZDHHC6	Q9H6R6	245	301	1	413	Chain	ID=PRO_0000212871;Note=Palmitoyltransferase ZDHHC6
ZDHHC6	Q9H6R6	173	227	1	413	Chain	ID=PRO_0000212871;Note=Palmitoyltransferase ZDHHC6
ZDHHC6	Q9H6R6	173	227	206	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC6	Q9H6R6	301	315	313	398	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ZFAND3	Q9H8U3	37	98	1	227	Chain	ID=PRO_0000076370;Note=AN1-type zinc finger protein 3
ZFAND3	Q9H8U3	98	120	1	227	Chain	ID=PRO_0000076370;Note=AN1-type zinc finger protein 3
ZFAND3	Q9H8U3	120	176	1	227	Chain	ID=PRO_0000076370;Note=AN1-type zinc finger protein 3
ZFAND3	Q9H8U3	37	98	12	44	Zinc finger	Note=A20-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00451
ZFAND3	Q9H8U3	120	176	154	200	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND3	Q9H8U3	98	120	120	120	Sequence conflict	Note=T->TA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND3	Q9H8U3	120	176	120	120	Sequence conflict	Note=T->TA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND3	Q9H8U3	98	120	120	120	Sequence conflict	Note=T->TA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND3	Q9H8U3	120	176	120	120	Sequence conflict	Note=T->TA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND3	Q9H8U3	98	120	120	120	Sequence conflict	Note=T->TA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND3	Q9H8U3	120	176	120	120	Sequence conflict	Note=T->TA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND3	Q9H8U3	120	176	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X4W
ZFAND3	Q9H8U3	120	176	166	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X4W
ZFAND3	Q9H8U3	120	176	175	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X4W
ZFP28	Q8NHY6	267	299	1	868	Chain	ID=PRO_0000047289;Note=Zinc finger protein 28 homolog
ZFP28	Q8NHY6	267	299	232	299	Domain	Note=KRAB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZMYM4	Q5VZL5	223	280	2	1548	Chain	ID=PRO_0000299017;Note=Zinc finger MYM-type protein 4
ZMYM4	Q5VZL5	452	523	2	1548	Chain	ID=PRO_0000299017;Note=Zinc finger MYM-type protein 4
ZMYM4	Q5VZL5	862	909	2	1548	Chain	ID=PRO_0000299017;Note=Zinc finger MYM-type protein 4
ZMYM4	Q5VZL5	452	523	414	457	Zinc finger	Note=MYM-type 2
ZMYM4	Q5VZL5	452	523	464	499	Zinc finger	Note=MYM-type 3
ZMYM4	Q5VZL5	452	523	510	544	Zinc finger	Note=MYM-type 4
ZMYM4	Q5VZL5	223	280	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZMYM4	Q5VZL5	223	280	232	232	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZMYM4	Q5VZL5	223	280	250	250	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
ZMYM4	Q5VZL5	223	280	250	250	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
ZMYM4	Q5VZL5	223	280	260	260	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZMYM4	Q5VZL5	223	280	271	271	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZMYM4	Q5VZL5	223	280	273	273	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
ZMYM4	Q5VZL5	223	280	1	324	Alternative sequence	ID=VSP_027512;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZMYM4	Q5VZL5	452	523	452	452	Natural variant	ID=VAR_034764;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9455477;Dbxref=dbSNP:rs34924462,PMID:9455477
ZMYM4	Q5VZL5	223	280	279	280	Sequence conflict	Note=AQ->RT;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZMIZ1	Q9ULJ6	20	58	1	1067	Chain	ID=PRO_0000218987;Note=Zinc finger MIZ domain-containing protein 1
ZMIZ1	Q9ULJ6	471	497	1	1067	Chain	ID=PRO_0000218987;Note=Zinc finger MIZ domain-containing protein 1
ZMIZ1	Q9ULJ6	785	807	1	1067	Chain	ID=PRO_0000218987;Note=Zinc finger MIZ domain-containing protein 1
ZMIZ1	Q9ULJ6	945	1032	1	1067	Chain	ID=PRO_0000218987;Note=Zinc finger MIZ domain-containing protein 1
ZMIZ1	Q9ULJ6	785	807	727	804	Zinc finger	Note=SP-RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00452
ZMIZ1	Q9ULJ6	20	58	1	120	Region	Note=Sufficient for transactivation activity%3B sufficient for interaction with NOTCH1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522984;Dbxref=PMID:26522984
ZMIZ1	Q9ULJ6	945	1032	837	1067	Region	Note=Transactivation domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522984;Dbxref=PMID:26522984
ZMIZ1	Q9ULJ6	471	497	334	555	Compositional bias	Note=Pro-rich
ZMIZ1	Q9ULJ6	945	1032	867	1002	Compositional bias	Note=Pro-rich
ZMIZ1	Q9ULJ6	20	58	1	70	Alternative sequence	ID=VSP_012185;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574462;Dbxref=PMID:10574462
ZMIZ1	Q9ULJ6	20	58	8	21	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AIZ
ZMIZ1	Q9ULJ6	20	58	25	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AIZ
ZMIZ1	Q9ULJ6	20	58	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AIZ
ZMIZ1	Q9ULJ6	20	58	47	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AIZ
ZNF236	Q9UL36	1636	1702	1	1845	Chain	ID=PRO_0000047476;Note=Zinc finger protein 236
ZNF236	Q9UL36	1636	1702	1657	1680	Zinc finger	Note=C2H2-type 26;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF236	Q9UL36	1636	1702	1686	1708	Zinc finger	Note=C2H2-type 27;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF236	Q9UL36	1636	1702	1559	1845	Alternative sequence	ID=VSP_006908;Note=In isoform A. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10458916;Dbxref=PMID:10458916
ZNF180	Q9UJW8	44	69	1	692	Chain	ID=PRO_0000047442;Note=Zinc finger protein 180
ZNF180	Q9UJW8	44	69	41	69	Alternative sequence	ID=VSP_056707;Note=In isoform 3. ACAQDSFLPQEIIIKVEGEDTGSLTIPSQ->ACAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF250	P15622	99	120	1	560	Chain	ID=PRO_0000047483;Note=Zinc finger protein 250
ZNF250	P15622	61	99	1	560	Chain	ID=PRO_0000047483;Note=Zinc finger protein 250
ZNF250	P15622	99	120	1	560	Chain	ID=PRO_0000047483;Note=Zinc finger protein 250
ZNF250	P15622	61	99	1	560	Chain	ID=PRO_0000047483;Note=Zinc finger protein 250
ZNF250	P15622	61	99	22	93	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF250	P15622	61	99	22	93	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF143	P52747	37	68	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	96	124	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	215	255	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	280	322	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	322	382	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	508	562	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	562	611	1	638	Chain	ID=PRO_0000047426;Note=Zinc finger protein 143
ZNF143	P52747	215	255	237	261	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF143	P52747	280	322	267	291	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF143	P52747	280	322	297	321	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF143	P52747	322	382	327	351	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF143	P52747	322	382	357	381	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF143	P52747	322	382	352	352	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF143	P52747	37	68	39	69	Alternative sequence	ID=VSP_036978;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF143	P52747	96	124	97	98	Alternative sequence	ID=VSP_055109;Note=In isoform 3. TG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF143	P52747	508	562	561	561	Natural variant	ID=VAR_027254;Note=E->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9776743;Dbxref=dbSNP:rs10743108,PMID:14702039,PMID:15489334,PMID:9776743
ZNF143	P52747	562	611	590	590	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF566	Q969W8	45	77	1	418	Chain	ID=PRO_0000047656;Note=Zinc finger protein 566
ZNF566	Q969W8	45	77	1	418	Chain	ID=PRO_0000047656;Note=Zinc finger protein 566
ZNF566	Q969W8	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF566	Q969W8	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF566	Q969W8	45	77	45	45	Alternative sequence	ID=VSP_043419;Note=In isoform 2. M->MA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF566	Q969W8	45	77	45	45	Alternative sequence	ID=VSP_043419;Note=In isoform 2. M->MA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF341	Q9BYN7	10	47	1	854	Chain	ID=PRO_0000047541;Note=Zinc finger protein 341
ZNF341	Q9BYN7	113	163	1	854	Chain	ID=PRO_0000047541;Note=Zinc finger protein 341
ZNF341	Q9BYN7	113	163	143	186	Compositional bias	Note=Pro-rich
ZNF710	Q8N1W2	486	550	1	664	Chain	ID=PRO_0000233708;Note=Zinc finger protein 710
ZNF710	Q8N1W2	486	550	491	513	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF710	Q8N1W2	486	550	519	541	Zinc finger	Note=C2H2-type 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF710	Q8N1W2	486	550	547	569	Zinc finger	Note=C2H2-type 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF827	Q17R98	794	840	1	1081	Chain	ID=PRO_0000325889;Note=Zinc finger protein 827
ZNF827	Q17R98	582	660	1	1081	Chain	ID=PRO_0000325889;Note=Zinc finger protein 827
ZNF827	Q17R98	794	840	817	839	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF827	Q17R98	582	660	587	587	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF827	Q17R98	582	660	597	597	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25755297;Dbxref=PMID:25755297
ZNF827	Q17R98	582	660	634	634	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF827	Q17R98	582	660	639	639	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF827	Q17R98	582	660	658	658	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF827	Q17R98	794	840	798	798	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF207	O43670	260	291	1	478	Chain	ID=PRO_0000047453;Note=BUB3-interacting and GLEBS motif-containing protein ZNF207
ZNF207	O43670	260	291	261	291	Alternative sequence	ID=VSP_006905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF678	Q5SXM1	10	41	1	525	Chain	ID=PRO_0000233998;Note=Zinc finger protein 678
ZNF789	Q5FWF6	50	88	1	425	Chain	ID=PRO_0000293697;Note=Zinc finger protein 789
ZNF789	Q5FWF6	50	88	11	82	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF789	Q5FWF6	50	88	1	95	Alternative sequence	ID=VSP_026561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF789	Q5FWF6	50	88	51	62	Alternative sequence	ID=VSP_046816;Note=In isoform 3. GFQFPKPEMICQ->VYFQFDAAIPLC;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF789	Q5FWF6	50	88	63	425	Alternative sequence	ID=VSP_046817;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF789	Q5FWF6	50	88	77	77	Natural variant	ID=VAR_052903;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6962772,PMID:15489334
ZNF790	Q6PG37	44	76	1	636	Chain	ID=PRO_0000261336;Note=Zinc finger protein 790
ZNF790	Q6PG37	44	76	5	76	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF800	Q2TB10	20	52	1	664	Chain	ID=PRO_0000304410;Note=Zinc finger protein 800
ZNF800	Q2TB10	20	52	1	664	Chain	ID=PRO_0000304410;Note=Zinc finger protein 800
ZNF800	Q2TB10	20	52	1	664	Chain	ID=PRO_0000304410;Note=Zinc finger protein 800
ZPBP	Q9BS86	69	111	45	351	Chain	ID=PRO_0000041598;Note=Zona pellucida-binding protein 1
ZNRF1	Q8ND25	141	173	2	227	Chain	ID=PRO_0000277799;Note=E3 ubiquitin-protein ligase ZNRF1
ZNRF1	Q8ND25	141	173	173	173	Alternative sequence	ID=VSP_023088;Note=In isoform 2. N->NGRIQRSLRGAQPEKTWLSGRTLQEQPWRTECSWAPMAQMQSYPHCPVENRE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
ZNRF1	Q8ND25	141	173	146	148	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YWR
ZNRF1	Q8ND25	141	173	154	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YWR
ZNRF1	Q8ND25	141	173	157	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YWR
ZNRF1	Q8ND25	141	173	173	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YWR
ZSCAN29	Q8IWY8	407	563	1	852	Chain	ID=PRO_0000234011;Note=Zinc finger and SCAN domain-containing protein 29
ZSCAN29	Q8IWY8	407	563	561	561	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZSCAN29	Q8IWY8	407	563	176	564	Alternative sequence	ID=VSP_018180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZSCAN29	Q8IWY8	407	563	495	557	Alternative sequence	ID=VSP_018181;Note=In isoform 3. SVRVAAPPNDGQEETASCPVQGTSEAEAQKQAEEADEATEEDSDDDEEDTEIPPGAVITRAPV->LKLDLRMKIIQNGIFLRKYNCIGHYLQDLKGKFPGIFIRVKAMRVTVDQEDSGQRPQGRKEEN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZSCAN29	Q8IWY8	407	563	558	852	Alternative sequence	ID=VSP_018182;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZW10	O43264	628	672	2	779	Chain	ID=PRO_0000184957;Note=Centromere/kinetochore protein zw10 homolog
ZW10	O43264	244	308	2	779	Chain	ID=PRO_0000184957;Note=Centromere/kinetochore protein zw10 homolog
ZW10	O43264	244	308	2	317	Region	Note=Interaction with RINT1
ZSCAN20	P17040	481	624	1	1043	Chain	ID=PRO_0000047360;Note=Zinc finger and SCAN domain-containing protein 20
ZSCAN20	P17040	481	624	1	1043	Chain	ID=PRO_0000047360;Note=Zinc finger and SCAN domain-containing protein 20
ZSCAN20	P17040	481	624	482	487	Alternative sequence	ID=VSP_036737;Note=In isoform 4. AGVHWG->GKNMGV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZSCAN20	P17040	481	624	482	487	Alternative sequence	ID=VSP_036737;Note=In isoform 4. AGVHWG->GKNMGV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZSCAN20	P17040	481	624	482	482	Alternative sequence	ID=VSP_036738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZSCAN20	P17040	481	624	482	482	Alternative sequence	ID=VSP_036738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZSCAN20	P17040	481	624	488	1043	Alternative sequence	ID=VSP_036739;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZSCAN20	P17040	481	624	488	1043	Alternative sequence	ID=VSP_036739;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF257	Q9Y2Q1	43	75	1	563	Chain	ID=PRO_0000047490;Note=Zinc finger protein 257
ZNF257	Q9Y2Q1	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF257	Q9Y2Q1	43	75	51	83	Alternative sequence	ID=VSP_040859;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF384	Q8TF68	391	444	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	304	364	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	229	303	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	101	117	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	391	444	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	304	364	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	229	303	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	101	117	1	577	Chain	ID=PRO_0000047552;Note=Zinc finger protein 384
ZNF384	Q8TF68	229	303	228	250	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	229	303	228	250	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	229	303	256	278	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	229	303	256	278	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	304	364	284	306	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	229	303	284	306	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	304	364	284	306	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	229	303	284	306	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	304	364	317	339	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	304	364	317	339	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	304	364	345	367	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	304	364	345	367	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	391	444	373	397	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	391	444	373	397	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	391	444	403	425	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	391	444	403	425	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	391	444	433	455	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	391	444	433	455	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF384	Q8TF68	101	117	102	156	Alternative sequence	ID=VSP_040314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF384	Q8TF68	101	117	102	156	Alternative sequence	ID=VSP_040314;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF384	Q8TF68	304	364	293	353	Alternative sequence	ID=VSP_040315;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF384	Q8TF68	229	303	293	353	Alternative sequence	ID=VSP_040315;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF384	Q8TF68	304	364	293	353	Alternative sequence	ID=VSP_040315;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF384	Q8TF68	229	303	293	353	Alternative sequence	ID=VSP_040315;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF384	Q8TF68	304	364	300	360	Alternative sequence	ID=VSP_006920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF384	Q8TF68	229	303	300	360	Alternative sequence	ID=VSP_006920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF384	Q8TF68	304	364	300	360	Alternative sequence	ID=VSP_006920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF384	Q8TF68	229	303	300	360	Alternative sequence	ID=VSP_006920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF451	Q9Y4E5	7	35	1	1061	Chain	ID=PRO_0000047598;Note=E3 SUMO-protein ligase ZNF451
ZNF451	Q9Y4E5	62	104	1	1061	Chain	ID=PRO_0000047598;Note=E3 SUMO-protein ligase ZNF451
ZNF451	Q9Y4E5	869	917	1	1061	Chain	ID=PRO_0000047598;Note=E3 SUMO-protein ligase ZNF451
ZNF451	Q9Y4E5	1023	1046	1	1061	Chain	ID=PRO_0000047598;Note=E3 SUMO-protein ligase ZNF451
ZNF451	Q9Y4E5	7	35	1	344	Region	Note=Important for interaction with SUMO1 and SUMO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18656483;Dbxref=PMID:18656483
ZNF451	Q9Y4E5	62	104	1	344	Region	Note=Important for interaction with SUMO1 and SUMO2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18656483;Dbxref=PMID:18656483
ZNF451	Q9Y4E5	7	35	1	246	Region	Note=Sufficient for E3 SUMO-protein ligase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26524493;Dbxref=PMID:26524493
ZNF451	Q9Y4E5	62	104	1	246	Region	Note=Sufficient for E3 SUMO-protein ligase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26524493;Dbxref=PMID:26524493
ZNF451	Q9Y4E5	7	35	30	37	Region	Note=Interaction with SUMO2 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26524494;Dbxref=PMID:26524494
ZNF451	Q9Y4E5	62	104	75	75	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
ZNF451	Q9Y4E5	62	104	77	77	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
ZNF451	Q9Y4E5	62	104	63	1061	Alternative sequence	ID=VSP_035312;Note=In isoform 3. ENIKRKDHIDYQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIRGHSDTEAARLCVDQWLKMPGLKTGTINCGTKSSFRRGGHTWVSGKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQQYRDHLFDKEATDDGHNNNLLPQIIQCFACPNCFLLFSRKEECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKTLRSHMELTAHFRVHCRNAGPVAVAEKSITQVAEKFILRGYCPDCNQVFVDETSTQNHKQNSGHKVRVINSVEESVLLYCHSSEGNKDPSSDLHLLLDQSKFSSLKRTMSIKESSSLECIAIPKKKMNLKDKSHEGVACVQKEKSVVKTWFCECNQRFPSEDAVEKHVFSANTMGYKCVVCGKVCDDSGVIRLHMSRIHGGAHLNNFLFWCRTCKKELTRKDTIMAHVTEFHNGHRYFYEMDEVEGETLPSSSTTLDNLTANKPSSAITVIDHSPANSSPRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEIKIKYFCGLCDLIFNVEEAFLSHYEEHHSIDYVFVSEKTETSIKTEDDFPVIETSNQLTCGCRESYICKVNRKEDYSRCLQIMLDKGKLWFRCSLCSATAQNLTDMNTHIHQVHKEKSDEEEQQYVIKCGTCTKAFHDPESAQQHFHRKHCFLQKPSVAHFGSEKSNLYKFTASASHTERKLKQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVELEEAIRRSLEEM->RMPESKVPSSENHRPEMCSSCNVPLPIGDSSSFSGSCSSSPERIVSQTSSVENPLENQKNDQNNSDTKISETETLKSSQNFQTLPSSPLLVPQESLASSEVKENLRIDSSSASQHGRDAILYLQTQVAEMSRVIRDLQSRSCFRFHHSRPSENSSVPWDISTSKEENLSTVEEETDYKSPSADDKGQPSDPSQSSFTGLLKRMEQRGVIKRVTLQSEAESCEGKPDCVTSKKRLVPPLHPLLRIATTEVFKDPADCHPSSFMGHRVYPVAKDTSPFQPNPPAEGPIVEALEHSKRGNTTSPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQYQRKLWEDMEDLVHDPEFDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVAEDNNIKENDYKDHKYYNQHRYFYSHDQKAHYHNRGYSKGDWYKPRNHPYRYRKKGDSPERHGYKN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334
ZNF451	Q9Y4E5	869	917	63	1061	Alternative sequence	ID=VSP_035312;Note=In isoform 3. ENIKRKDHIDYQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIRGHSDTEAARLCVDQWLKMPGLKTGTINCGTKSSFRRGGHTWVSGKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQQYRDHLFDKEATDDGHNNNLLPQIIQCFACPNCFLLFSRKEECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKTLRSHMELTAHFRVHCRNAGPVAVAEKSITQVAEKFILRGYCPDCNQVFVDETSTQNHKQNSGHKVRVINSVEESVLLYCHSSEGNKDPSSDLHLLLDQSKFSSLKRTMSIKESSSLECIAIPKKKMNLKDKSHEGVACVQKEKSVVKTWFCECNQRFPSEDAVEKHVFSANTMGYKCVVCGKVCDDSGVIRLHMSRIHGGAHLNNFLFWCRTCKKELTRKDTIMAHVTEFHNGHRYFYEMDEVEGETLPSSSTTLDNLTANKPSSAITVIDHSPANSSPRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEIKIKYFCGLCDLIFNVEEAFLSHYEEHHSIDYVFVSEKTETSIKTEDDFPVIETSNQLTCGCRESYICKVNRKEDYSRCLQIMLDKGKLWFRCSLCSATAQNLTDMNTHIHQVHKEKSDEEEQQYVIKCGTCTKAFHDPESAQQHFHRKHCFLQKPSVAHFGSEKSNLYKFTASASHTERKLKQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVELEEAIRRSLEEM->RMPESKVPSSENHRPEMCSSCNVPLPIGDSSSFSGSCSSSPERIVSQTSSVENPLENQKNDQNNSDTKISETETLKSSQNFQTLPSSPLLVPQESLASSEVKENLRIDSSSASQHGRDAILYLQTQVAEMSRVIRDLQSRSCFRFHHSRPSENSSVPWDISTSKEENLSTVEEETDYKSPSADDKGQPSDPSQSSFTGLLKRMEQRGVIKRVTLQSEAESCEGKPDCVTSKKRLVPPLHPLLRIATTEVFKDPADCHPSSFMGHRVYPVAKDTSPFQPNPPAEGPIVEALEHSKRGNTTSPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQYQRKLWEDMEDLVHDPEFDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVAEDNNIKENDYKDHKYYNQHRYFYSHDQKAHYHNRGYSKGDWYKPRNHPYRYRKKGDSPERHGYKN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334
ZNF451	Q9Y4E5	1023	1046	63	1061	Alternative sequence	ID=VSP_035312;Note=In isoform 3. ENIKRKDHIDYQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIRGHSDTEAARLCVDQWLKMPGLKTGTINCGTKSSFRRGGHTWVSGKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQQYRDHLFDKEATDDGHNNNLLPQIIQCFACPNCFLLFSRKEECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKTLRSHMELTAHFRVHCRNAGPVAVAEKSITQVAEKFILRGYCPDCNQVFVDETSTQNHKQNSGHKVRVINSVEESVLLYCHSSEGNKDPSSDLHLLLDQSKFSSLKRTMSIKESSSLECIAIPKKKMNLKDKSHEGVACVQKEKSVVKTWFCECNQRFPSEDAVEKHVFSANTMGYKCVVCGKVCDDSGVIRLHMSRIHGGAHLNNFLFWCRTCKKELTRKDTIMAHVTEFHNGHRYFYEMDEVEGETLPSSSTTLDNLTANKPSSAITVIDHSPANSSPRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEIKIKYFCGLCDLIFNVEEAFLSHYEEHHSIDYVFVSEKTETSIKTEDDFPVIETSNQLTCGCRESYICKVNRKEDYSRCLQIMLDKGKLWFRCSLCSATAQNLTDMNTHIHQVHKEKSDEEEQQYVIKCGTCTKAFHDPESAQQHFHRKHCFLQKPSVAHFGSEKSNLYKFTASASHTERKLKQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVELEEAIRRSLEEM->RMPESKVPSSENHRPEMCSSCNVPLPIGDSSSFSGSCSSSPERIVSQTSSVENPLENQKNDQNNSDTKISETETLKSSQNFQTLPSSPLLVPQESLASSEVKENLRIDSSSASQHGRDAILYLQTQVAEMSRVIRDLQSRSCFRFHHSRPSENSSVPWDISTSKEENLSTVEEETDYKSPSADDKGQPSDPSQSSFTGLLKRMEQRGVIKRVTLQSEAESCEGKPDCVTSKKRLVPPLHPLLRIATTEVFKDPADCHPSSFMGHRVYPVAKDTSPFQPNPPAEGPIVEALEHSKRGNTTSPLDSTSKEMEVMGCRFYHAASIAARAASYMAYMTQYQRKLWEDMEDLVHDPEFDRGKARCIISDGMDAGLWQLCTTRDIMDSVVRVMAMAIDYRRQAWLRLTSLTKKTQEKISHLPFDGTSLFGQDVKAVVAEDNNIKENDYKDHKYYNQHRYFYSHDQKAHYHNRGYSKGDWYKPRNHPYRYRKKGDSPERHGYKN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334
ZNF451	Q9Y4E5	869	917	870	917	Alternative sequence	ID=VSP_008624;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ZNF451	Q9Y4E5	7	35	31	34	Mutagenesis	Note=Nearly abolishes E3 SUMO-protein ligase activity (in vitro). IQFV->AQAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26524493;Dbxref=PMID:26524493
ZNF451	Q9Y4E5	7	35	32	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D2M
ZNF461	Q8TAF7	77	100	1	563	Chain	ID=PRO_0000047196;Note=Zinc finger protein 461
ZNF461	Q8TAF7	77	100	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF461	Q8TAF7	77	100	1	127	Alternative sequence	ID=VSP_011396;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF461	Q8TAF7	77	100	87	87	Natural variant	ID=VAR_052834;Note=N->S;Dbxref=dbSNP:rs10419469
ZNF839	A8K0R7	281	356	1	811	Chain	ID=PRO_0000328721;Note=Zinc finger protein 839
ZNF839	A8K0R7	387	437	1	811	Chain	ID=PRO_0000328721;Note=Zinc finger protein 839
ZNF839	A8K0R7	281	356	1	811	Chain	ID=PRO_0000328721;Note=Zinc finger protein 839
ZNF839	A8K0R7	387	437	1	811	Chain	ID=PRO_0000328721;Note=Zinc finger protein 839
ZNF839	A8K0R7	281	356	314	314	Natural variant	ID=VAR_057456;Note=A->T;Dbxref=dbSNP:rs1543540
ZNF839	A8K0R7	281	356	314	314	Natural variant	ID=VAR_057456;Note=A->T;Dbxref=dbSNP:rs1543540
ZNF839	A8K0R7	387	437	411	411	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF839	A8K0R7	387	437	411	411	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF839	A8K0R7	387	437	418	418	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF839	A8K0R7	387	437	418	418	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF862	O60290	407	1111	1	1169	Chain	ID=PRO_0000320644;Note=Zinc finger protein 862
ZNF862	O60290	407	1111	461	544	Zinc finger	Note=TTF-type 2
ZNF862	O60290	407	1111	1	915	Alternative sequence	ID=VSP_031702;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF862	O60290	407	1111	916	923	Alternative sequence	ID=VSP_031703;Note=In isoform 2. RFQADRER->MGRRWCEW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC30A6	Q6NXT4	1	30	1	461	Chain	ID=PRO_0000312573;Note=Zinc transporter 6
SLC30A6	Q6NXT4	73	94	1	461	Chain	ID=PRO_0000312573;Note=Zinc transporter 6
SLC30A6	Q6NXT4	95	121	1	461	Chain	ID=PRO_0000312573;Note=Zinc transporter 6
SLC30A6	Q6NXT4	256	272	1	461	Chain	ID=PRO_0000312573;Note=Zinc transporter 6
SLC30A6	Q6NXT4	272	295	1	461	Chain	ID=PRO_0000312573;Note=Zinc transporter 6
SLC30A6	Q6NXT4	1	30	1	33	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	73	94	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	73	94	86	98	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	95	121	86	98	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	95	121	99	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	95	121	120	134	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	256	272	245	461	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	272	295	245	461	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A6	Q6NXT4	1	30	1	30	Alternative sequence	ID=VSP_045198;Note=In isoform 4. MGTIHLFRKPQRSFFGKLLREFRLVAADRR->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC30A6	Q6NXT4	272	295	273	295	Alternative sequence	ID=VSP_029862;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC30A9	Q6PML9	91	111	1	568	Chain	ID=PRO_0000295805;Note=Zinc transporter 9
SLC30A9	Q6PML9	516	554	1	568	Chain	ID=PRO_0000295805;Note=Zinc transporter 9
SLC30A9	Q6PML9	91	111	97	97	Natural variant	ID=VAR_052004;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10409434,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2581423,PMID:10409434,PMID:15489334
ZSCAN18	Q8TBC5	134	184	1	510	Chain	ID=PRO_0000243921;Note=Zinc finger and SCAN domain-containing protein 18
ZSCAN18	Q8TBC5	134	184	1	510	Chain	ID=PRO_0000243921;Note=Zinc finger and SCAN domain-containing protein 18
ZSCAN18	Q8TBC5	134	184	1	135	Alternative sequence	ID=VSP_047060;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZSCAN18	Q8TBC5	134	184	1	135	Alternative sequence	ID=VSP_047060;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZWILCH	Q9H900	35	67	1	591	Chain	ID=PRO_0000314800;Note=Protein zwilch homolog
ZWILCH	Q9H900	249	273	1	591	Chain	ID=PRO_0000314800;Note=Protein zwilch homolog
ZWILCH	Q9H900	35	67	1	114	Alternative sequence	ID=VSP_030365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
ZWILCH	Q9H900	35	67	32	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IF8
ZWILCH	Q9H900	35	67	50	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IF8
ZWILCH	Q9H900	35	67	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IF8
ZWILCH	Q9H900	249	273	245	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IF8
ZWILCH	Q9H900	249	273	267	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IF8
ZXDC	Q2QGD7	423	480	1	858	Chain	ID=PRO_0000292803;Note=Zinc finger protein ZXDC
ZXDC	Q2QGD7	423	480	418	442	Zinc finger	Note=C2H2-type 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZXDC	Q2QGD7	423	480	451	476	Zinc finger	Note=C2H2-type 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZDHHC14	Q8IZN3	135	188	1	488	Chain	ID=PRO_0000212891;Note=Probable palmitoyltransferase ZDHHC14
ZDHHC14	Q8IZN3	188	234	1	488	Chain	ID=PRO_0000212891;Note=Probable palmitoyltransferase ZDHHC14
ZDHHC14	Q8IZN3	188	234	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC14	Q8IZN3	135	188	165	215	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC14	Q8IZN3	188	234	165	215	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC14	Q8IZN3	188	234	195	195	Active site	Note=S-palmitoyl cysteine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZC3H15	Q8WU90	239	288	1	426	Chain	ID=PRO_0000324642;Note=Zinc finger CCCH domain-containing protein 15
ZC3H15	Q8WU90	239	288	236	260	Region	Note=Required for interaction with DRG1;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZC3H15	Q8WU90	239	288	218	285	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC4	Q9NPG8	123	165	1	344	Chain	ID=PRO_0000212865;Note=Probable palmitoyltransferase ZDHHC4
ZDHHC4	Q9NPG8	123	165	1	344	Chain	ID=PRO_0000212865;Note=Probable palmitoyltransferase ZDHHC4
ZDHHC4	Q9NPG8	123	165	1	344	Chain	ID=PRO_0000212865;Note=Probable palmitoyltransferase ZDHHC4
ZDHHC4	Q9NPG8	123	165	1	344	Chain	ID=PRO_0000212865;Note=Probable palmitoyltransferase ZDHHC4
ZDHHC4	Q9NPG8	123	165	1	344	Chain	ID=PRO_0000212865;Note=Probable palmitoyltransferase ZDHHC4
ZDHHC4	Q9NPG8	123	165	1	344	Chain	ID=PRO_0000212865;Note=Probable palmitoyltransferase ZDHHC4
ZDHHC4	Q9NPG8	123	165	149	199	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC4	Q9NPG8	123	165	149	199	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC4	Q9NPG8	123	165	149	199	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC4	Q9NPG8	123	165	149	199	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC4	Q9NPG8	123	165	149	199	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC4	Q9NPG8	123	165	149	199	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC18	Q9NUE0	215	261	1	388	Chain	ID=PRO_0000212902;Note=Palmitoyltransferase ZDHHC18
ZDHHC18	Q9NUE0	215	261	236	256	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC18	Q9NUE0	215	261	192	242	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC18	Q9NUE0	215	261	222	222	Active site	Note=S-palmitoyl cysteine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZCCHC9	Q8N567	209	232	1	271	Chain	ID=PRO_0000150965;Note=Zinc finger CCHC domain-containing protein 9
ZCCHC9	Q8N567	209	232	1	271	Chain	ID=PRO_0000150965;Note=Zinc finger CCHC domain-containing protein 9
ZCCHC9	Q8N567	209	232	1	271	Chain	ID=PRO_0000150965;Note=Zinc finger CCHC domain-containing protein 9
ZCCHC9	Q8N567	209	232	1	271	Chain	ID=PRO_0000150965;Note=Zinc finger CCHC domain-containing protein 9
ZCCHC9	Q8N567	209	232	211	228	Zinc finger	Note=CCHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047
ZCCHC9	Q8N567	209	232	211	228	Zinc finger	Note=CCHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047
ZCCHC9	Q8N567	209	232	211	228	Zinc finger	Note=CCHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047
ZCCHC9	Q8N567	209	232	211	228	Zinc finger	Note=CCHC-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047
ZFAND5	O76080	122	164	1	213	Chain	ID=PRO_0000066557;Note=AN1-type zinc finger protein 5
ZFAND5	O76080	122	164	1	213	Chain	ID=PRO_0000066557;Note=AN1-type zinc finger protein 5
ZFAND5	O76080	122	164	1	213	Chain	ID=PRO_0000066557;Note=AN1-type zinc finger protein 5
ZFAND5	O76080	122	164	1	213	Chain	ID=PRO_0000066557;Note=AN1-type zinc finger protein 5
ZFAND5	O76080	122	164	151	194	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND5	O76080	122	164	151	194	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND5	O76080	122	164	151	194	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND5	O76080	122	164	151	194	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZMYND15	Q9H091	276	327	1	742	Chain	ID=PRO_0000218317;Note=Zinc finger MYND domain-containing protein 15
ZMYND15	Q9H091	459	498	1	742	Chain	ID=PRO_0000218317;Note=Zinc finger MYND domain-containing protein 15
ZMYND15	Q9H091	276	327	313	359	Zinc finger	Note=MYND-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134
ZMYND15	Q9H091	459	498	460	499	Alternative sequence	ID=VSP_042144;Note=In isoform 2. GSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSF->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
ZMAT3	Q9HA38	90	130	1	289	Chain	ID=PRO_0000310779;Note=Zinc finger matrin-type protein 3
ZMAT3	Q9HA38	90	130	70	100	Zinc finger	Note=Matrin-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNF160	Q9HCG1	47	90	1	818	Chain	ID=PRO_0000047433;Note=Zinc finger protein 160
ZNF160	Q9HCG1	47	90	1	818	Chain	ID=PRO_0000047433;Note=Zinc finger protein 160
ZNF160	Q9HCG1	47	90	1	818	Chain	ID=PRO_0000047433;Note=Zinc finger protein 160
ZNF160	Q9HCG1	47	90	8	79	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF160	Q9HCG1	47	90	8	79	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF160	Q9HCG1	47	90	8	79	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF160	Q9HCG1	47	90	82	82	Natural variant	ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164
ZNF160	Q9HCG1	47	90	82	82	Natural variant	ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164
ZNF160	Q9HCG1	47	90	82	82	Natural variant	ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164
ZNF429	Q86V71	43	75	1	674	Chain	ID=PRO_0000047577;Note=Zinc finger protein 429
ZNF429	Q86V71	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF135	P52742	53	85	1	658	Chain	ID=PRO_0000047419;Note=Zinc finger protein 135
ZNF135	P52742	53	85	14	85	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF135	P52742	53	85	85	85	Alternative sequence	ID=VSP_046706;Note=In isoform 3 and isoform 4. P->PEIKGHFQFLLLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF467	Q7Z7K2	50	87	1	595	Chain	ID=PRO_0000247517;Note=Zinc finger protein 467
ZNF467	Q7Z7K2	11	50	1	595	Chain	ID=PRO_0000247517;Note=Zinc finger protein 467
ZNF18	P17022	250	287	1	549	Chain	ID=PRO_0000047340;Note=Zinc finger protein 18
ZNF18	P17022	250	287	1	549	Chain	ID=PRO_0000047340;Note=Zinc finger protein 18
ZNF18	P17022	250	287	211	283	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF18	P17022	250	287	211	283	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF18	P17022	250	287	251	251	Alternative sequence	ID=VSP_016947;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16120570;Dbxref=PMID:16120570
ZNF18	P17022	250	287	251	251	Alternative sequence	ID=VSP_016947;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16120570;Dbxref=PMID:16120570
ZNF26	P17031	53	85	1	533	Chain	ID=PRO_0000047355;Note=Zinc finger protein 26
ZNF26	P17031	53	85	14	85	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF683	Q8IZ20	381	401	1	524	Chain	ID=PRO_0000234002;Note=Tissue-resident T-cell transcription regulator protein ZNF683
ZNF683	Q8IZ20	381	401	1	524	Chain	ID=PRO_0000234002;Note=Tissue-resident T-cell transcription regulator protein ZNF683
ZNF683	Q8IZ20	381	401	398	420	Zinc finger	Note=C2H2-type 3%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF683	Q8IZ20	381	401	398	420	Zinc finger	Note=C2H2-type 3%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF683	Q8IZ20	381	401	382	401	Alternative sequence	ID=VSP_018167;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF683	Q8IZ20	381	401	382	401	Alternative sequence	ID=VSP_018167;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TJP1	Q07157	1689	1717	1	1748	Chain	ID=PRO_0000094540;Note=Tight junction protein ZO-1
TJP1	Q07157	921	1001	1	1748	Chain	ID=PRO_0000094540;Note=Tight junction protein ZO-1
TJP1	Q07157	640	672	1	1748	Chain	ID=PRO_0000094540;Note=Tight junction protein ZO-1
TJP1	Q07157	640	672	598	779	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
TJP1	Q07157	1689	1717	1634	1748	Domain	Note=ZU5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00485
TJP1	Q07157	640	672	633	876	Region	Note=Occludin (OCLN)-binding region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9792688;Dbxref=PMID:9792688
TJP1	Q07157	921	1001	968	968	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
TJP1	Q07157	921	1001	922	1001	Alternative sequence	ID=VSP_003148;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TJP1	Q07157	921	1001	930	930	Natural variant	ID=VAR_025155;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs45529137
TJP1	Q07157	1689	1717	1699	1700	Mutagenesis	Note=Abolishes interaction with CDC42BPB. MC->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21240187;Dbxref=PMID:21240187
TJP1	Q07157	640	672	632	640	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TSZ
TJP1	Q07157	640	672	647	651	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TSZ
TJP1	Q07157	640	672	654	664	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TSZ
TJP1	Q07157	640	672	666	668	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TSZ
TJP1	Q07157	640	672	669	671	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TSZ
TJP1	Q07157	1689	1717	1687	1689	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KXR
TJP1	Q07157	1689	1717	1701	1703	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KXR
TJP1	Q07157	1689	1717	1706	1715	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KXR
SLC30A3	Q99726	294	339	1	388	Chain	ID=PRO_0000206096;Note=Zinc transporter 3
SLC30A3	Q99726	294	339	286	388	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A3	Q99726	294	339	298	298	Natural variant	ID=VAR_077209;Note=Rare polymorphism%3B may be associated with increased risk for febrile seizures%3B the mutant has decreased localization to synaptic vesicles. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26647834;Dbxref=dbSNP:rs146572471,PMID:26647834
ZNF91	Q05481	52	84	1	1191	Chain	ID=PRO_0000047400;Note=Zinc finger protein 91
ZNF91	Q05481	52	84	13	84	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF91	Q05481	52	84	55	86	Alternative sequence	ID=VSP_040288;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HDLBP	Q00341	1125	1164	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	1015	1063	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	935	970	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	690	764	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	544	573	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	506	544	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	363	398	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	114	186	2	1268	Chain	ID=PRO_0000050131;Note=Vigilin
HDLBP	Q00341	114	186	158	229	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	363	398	303	371	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	363	398	372	442	Domain	Note=KH 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	506	544	443	514	Domain	Note=KH 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	544	573	515	588	Domain	Note=KH 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	506	544	515	588	Domain	Note=KH 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	690	764	661	734	Domain	Note=KH 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	690	764	735	807	Domain	Note=KH 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	935	970	881	979	Domain	Note=KH 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	1015	1063	980	1059	Domain	Note=KH 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	1125	1164	1060	1134	Domain	Note=KH 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	1015	1063	1060	1134	Domain	Note=KH 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	1125	1164	1135	1209	Domain	Note=KH 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
HDLBP	Q00341	544	573	568	568	Natural variant	ID=VAR_036052;Note=In a breast cancer sample%3B somatic mutation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
HDLBP	Q00341	935	970	939	939	Natural variant	ID=VAR_036053;Note=In a breast cancer sample%3B somatic mutation. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
HDLBP	Q00341	114	186	151	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTE
HDLBP	Q00341	114	186	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTE
HDLBP	Q00341	114	186	162	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTE
HDLBP	Q00341	114	186	168	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTE
HDLBP	Q00341	114	186	172	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTE
HDLBP	Q00341	363	398	365	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTF
HDLBP	Q00341	363	398	376	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTF
HDLBP	Q00341	363	398	381	384	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTF
HDLBP	Q00341	363	398	386	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTF
HDLBP	Q00341	363	398	395	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTF
HDLBP	Q00341	690	764	693	696	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTJ
HDLBP	Q00341	690	764	699	704	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTJ
HDLBP	Q00341	690	764	706	723	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTJ
HDLBP	Q00341	1015	1063	1017	1022	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTK
HDLBP	Q00341	1015	1063	1024	1050	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTK
HDLBP	Q00341	1015	1063	1054	1058	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTL
HDLBP	Q00341	1015	1063	1061	1063	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTL
HDLBP	Q00341	1125	1164	1107	1126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTL
HDLBP	Q00341	1125	1164	1130	1133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTM
HDLBP	Q00341	1125	1164	1136	1138	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTM
HDLBP	Q00341	1125	1164	1139	1143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTM
HDLBP	Q00341	1125	1164	1145	1147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTM
HDLBP	Q00341	1125	1164	1149	1157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTM
HDLBP	Q00341	1125	1164	1160	1162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTM
TCIRG1	Q13488	269	340	1	830	Chain	ID=PRO_0000119218;Note=V-type proton ATPase 116 kDa subunit a isoform 3
TCIRG1	Q13488	269	340	1	385	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG4	Q9Y279	278	313	20	399	Chain	ID=PRO_0000015006;Note=V-set and immunoglobulin domain-containing protein 4
VSIG4	Q9Y279	137	231	20	399	Chain	ID=PRO_0000015006;Note=V-set and immunoglobulin domain-containing protein 4
VSIG4	Q9Y279	278	313	20	283	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG4	Q9Y279	137	231	20	283	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG4	Q9Y279	278	313	284	304	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG4	Q9Y279	278	313	305	399	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG4	Q9Y279	137	231	143	226	Domain	Note=Ig-like 2
VSIG4	Q9Y279	137	231	165	211	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VSIG4	Q9Y279	137	231	138	232	Alternative sequence	ID=VSP_041213;Note=In isoform 3. LSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKD->H;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
VSIG4	Q9Y279	278	313	279	279	Natural variant	ID=VAR_049958;Note=G->E;Dbxref=dbSNP:rs17315645
VWF	P04275	18	73	1	22	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3495266;Dbxref=PMID:3495266
VWF	P04275	18	73	23	763	Chain	ID=PRO_0000022682;Note=von Willebrand antigen 2
VWF	P04275	2629	2662	764	2813	Chain	ID=PRO_0000022683;Note=von Willebrand factor
VWF	P04275	2300	2325	764	2813	Chain	ID=PRO_0000022683;Note=von Willebrand factor
VWF	P04275	1126	1179	764	2813	Chain	ID=PRO_0000022683;Note=von Willebrand factor
VWF	P04275	989	1036	764	2813	Chain	ID=PRO_0000022683;Note=von Willebrand factor
VWF	P04275	895	940	764	2813	Chain	ID=PRO_0000022683;Note=von Willebrand factor
VWF	P04275	18	73	34	240	Domain	Note=VWFD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00580
VWF	P04275	989	1036	866	1074	Domain	Note=VWFD 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00580
VWF	P04275	895	940	866	1074	Domain	Note=VWFD 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00580
VWF	P04275	1126	1179	1146	1196	Domain	Note=TIL 4
VWF	P04275	2300	2325	2255	2328	Domain	Note=VWFC 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
VWF	P04275	2629	2662	2580	2645	Domain	Note=VWFC 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
VWF	P04275	1126	1179	1147	1147	Glycosylation	Note=N-linked (GlcNAc...) asparagine%3B atypical
VWF	P04275	989	1036	867	996	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	895	940	867	996	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	989	1036	889	1031	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	895	940	889	1031	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	989	1036	898	993	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	895	940	898	993	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	895	940	914	921	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	1126	1179	1126	1130	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	1126	1179	1149	1169	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	1126	1179	1153	1165	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3502076;Dbxref=PMID:3502076
VWF	P04275	18	73	1	18	Alternative sequence	ID=VSP_056527;Note=In isoform 2. MIPARFAGVLLALALILP->MGAQDEEEGIQDLDGLLVFDKIVEVTLLNLPWYNEETEGQRGEMTAPKSPRAKIR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWF	P04275	2629	2662	315	2813	Alternative sequence	ID=VSP_056529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWF	P04275	2300	2325	315	2813	Alternative sequence	ID=VSP_056529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWF	P04275	1126	1179	315	2813	Alternative sequence	ID=VSP_056529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWF	P04275	989	1036	315	2813	Alternative sequence	ID=VSP_056529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWF	P04275	895	940	315	2813	Alternative sequence	ID=VSP_056529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWF	P04275	1126	1179	1149	1149	Natural variant	ID=VAR_064925;Note=In VWD1%3B reduced secretion of homodimers and heterodimers with wild type VWD and increased degradation by the proteasome. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11698279;Dbxref=dbSNP:rs61748511,PMID:11698279
VWF	P04275	1126	1179	1149	1149	Mutagenesis	Note=Reduced secretion and increased intracellular retention. Similar phenotype%3B when associated with S-1169. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11698279;Dbxref=PMID:11698279
VWF	P04275	1126	1179	1169	1169	Mutagenesis	Note=Reduced secretion and increased intracellular retention. Similar phenotype%3B when associated with R-1149. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11698279;Dbxref=PMID:11698279
WDR72	Q3MJ13	367	449	1	1102	Chain	ID=PRO_0000241447;Note=WD repeat-containing protein 72
WDR72	Q3MJ13	197	237	1	1102	Chain	ID=PRO_0000241447;Note=WD repeat-containing protein 72
WDR72	Q3MJ13	367	449	1	1102	Chain	ID=PRO_0000241447;Note=WD repeat-containing protein 72
WDR72	Q3MJ13	197	237	1	1102	Chain	ID=PRO_0000241447;Note=WD repeat-containing protein 72
WDR72	Q3MJ13	197	237	160	197	Repeat	Note=WD 3
WDR72	Q3MJ13	197	237	160	197	Repeat	Note=WD 3
WDR72	Q3MJ13	367	449	402	441	Repeat	Note=WD 5
WDR72	Q3MJ13	367	449	402	441	Repeat	Note=WD 5
WDR72	Q3MJ13	367	449	399	399	Natural variant	ID=VAR_057633;Note=K->Q;Dbxref=dbSNP:rs35258188
WDR72	Q3MJ13	367	449	399	399	Natural variant	ID=VAR_057633;Note=K->Q;Dbxref=dbSNP:rs35258188
WSB1	Q9Y6I7	159	203	1	421	Chain	ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1
WSB1	Q9Y6I7	295	332	1	421	Chain	ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1
WSB1	Q9Y6I7	333	368	1	421	Chain	ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1
WSB1	Q9Y6I7	159	203	124	165	Repeat	Note=WD 2
WSB1	Q9Y6I7	159	203	168	208	Repeat	Note=WD 3
WSB1	Q9Y6I7	295	332	309	346	Repeat	Note=WD 6
WSB1	Q9Y6I7	333	368	309	346	Repeat	Note=WD 6
WSB1	Q9Y6I7	159	203	14	159	Alternative sequence	ID=VSP_006792;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
WSB1	Q9Y6I7	159	203	36	237	Alternative sequence	ID=VSP_053403;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
WSB1	Q9Y6I7	295	332	245	421	Alternative sequence	ID=VSP_039112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WSB1	Q9Y6I7	333	368	245	421	Alternative sequence	ID=VSP_039112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WSB1	Q9Y6I7	159	203	171	171	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
WSB1	Q9Y6I7	159	203	178	178	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
WSB1	Q9Y6I7	159	203	201	201	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC7A11	Q9UPY5	173	215	1	501	Chain	ID=PRO_0000054279;Note=Cystine/glutamate transporter
SLC7A11	Q9UPY5	173	215	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A11	Q9UPY5	173	215	180	189	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A11	Q9UPY5	173	215	190	210	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A11	Q9UPY5	173	215	211	234	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XDH	P47989	1258	1317	1	1333	Chain	ID=PRO_0000166084;Note=Xanthine dehydrogenase/oxidase
XDH	P47989	1049	1092	1	1333	Chain	ID=PRO_0000166084;Note=Xanthine dehydrogenase/oxidase
XDH	P47989	1258	1317	1262	1262	Active site	Note=Proton acceptor
XDH	P47989	1049	1092	1080	1080	Metal binding	Note=Molybdenum%3B via amide nitrogen
XDH	P47989	1049	1092	1074	1074	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
XDH	P47989	1258	1317	509	1318	Disulfide bond	Note=In oxidase form;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12
XDH	P47989	1049	1092	509	1318	Disulfide bond	Note=In oxidase form;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.12
XDH	P47989	1049	1092	1091	1091	Natural variant	ID=VAR_023988;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs45619033
XDH	P47989	1258	1317	1296	1296	Natural variant	ID=VAR_023991;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs45564939
XDH	P47989	1049	1092	1043	1055	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1049	1092	1059	1061	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1049	1092	1069	1071	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1049	1092	1083	1108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1258	1317	1263	1268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1258	1317	1269	1286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1258	1317	1303	1309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
XDH	P47989	1258	1317	1315	1317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E1Q
VPS4B	O75351	364	411	1	444	Chain	ID=PRO_0000084767;Note=Vacuolar protein sorting-associated protein 4B
VPS4B	O75351	364	411	410	410	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
VPS4B	O75351	364	411	390	396	Mutagenesis	Note=Abolishes interaction with VTA1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18385515;Dbxref=PMID:18385515
VPS4B	O75351	364	411	360	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VPS4B	O75351	364	411	375	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VPS4B	O75351	364	411	386	388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VPS4B	O75351	364	411	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VPS4B	O75351	364	411	396	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VPS4B	O75351	364	411	401	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VPS4B	O75351	364	411	411	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XWI
VWA1	Q6PCB0	24	210	23	445	Chain	ID=PRO_0000307156;Note=von Willebrand factor A domain-containing protein 1
VWA1	Q6PCB0	24	210	34	213	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
VWA1	Q6PCB0	24	210	74	74	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
VWA1	Q6PCB0	24	210	80	80	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
VWA1	Q6PCB0	24	210	83	83	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
VWA1	Q6PCB0	24	210	93	93	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
VWA1	Q6PCB0	24	210	1	212	Alternative sequence	ID=VSP_028617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VWA1	Q6PCB0	24	210	26	64	Alternative sequence	ID=VSP_046651;Note=In isoform 3. PPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPL->AQGPGRHRVHCQHRPRQLPGAVSRCLSPCREAPALCGRG;Ontology_term=ECO:0000305;evidence=ECO:0000305
VWA1	Q6PCB0	24	210	65	445	Alternative sequence	ID=VSP_046652;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
VWA2	Q5GFL6	296	332	24	755	Chain	ID=PRO_0000307362;Note=von Willebrand factor A domain-containing protein 2
VWA2	Q5GFL6	332	523	24	755	Chain	ID=PRO_0000307362;Note=von Willebrand factor A domain-containing protein 2
VWA2	Q5GFL6	707	749	24	755	Chain	ID=PRO_0000307362;Note=von Willebrand factor A domain-containing protein 2
VWA2	Q5GFL6	296	332	296	333	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	332	523	296	333	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	332	523	343	517	Domain	Note=VWFA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
VWA2	Q5GFL6	707	749	712	748	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	296	332	299	310	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	296	332	304	320	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	296	332	322	332	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	332	523	322	332	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	707	749	716	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	707	749	721	736	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	707	749	738	747	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWA2	Q5GFL6	296	332	1	304	Alternative sequence	ID=VSP_028737;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWA2	Q5GFL6	296	332	305	332	Alternative sequence	ID=VSP_028738;Note=In isoform 3. QNGGTCVPEGLDGYQCLCPLAFGGEANC->MEAHVFQKDWTATSASARWPLEGRLTVV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWA2	Q5GFL6	332	523	305	332	Alternative sequence	ID=VSP_028738;Note=In isoform 3. QNGGTCVPEGLDGYQCLCPLAFGGEANC->MEAHVFQKDWTATSASARWPLEGRLTVV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWA2	Q5GFL6	707	749	708	755	Alternative sequence	ID=VSP_028739;Note=In isoform 2 and isoform 3. EAKQPVNLCKPSPCMNEGSCVLQNGSYRCKCRDGWEGPHCENRFLRRP->GEWGNPHPQGCPHGRPSA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
VWA2	Q5GFL6	332	523	428	428	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR47	O94967	799	872	1	919	Chain	ID=PRO_0000051397;Note=WD repeat-containing protein 47
WDR47	O94967	755	799	1	919	Chain	ID=PRO_0000051397;Note=WD repeat-containing protein 47
WDR47	O94967	698	755	1	919	Chain	ID=PRO_0000051397;Note=WD repeat-containing protein 47
WDR47	O94967	53	80	1	919	Chain	ID=PRO_0000051397;Note=WD repeat-containing protein 47
WDR47	O94967	53	80	45	102	Domain	Note=CTLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00058
WDR47	O94967	698	755	659	698	Repeat	Note=WD 2
WDR47	O94967	698	755	706	748	Repeat	Note=WD 3
WDR47	O94967	755	799	753	791	Repeat	Note=WD 4
WDR47	O94967	698	755	753	791	Repeat	Note=WD 4
WDR47	O94967	799	872	798	837	Repeat	Note=WD 5
WDR47	O94967	755	799	798	837	Repeat	Note=WD 5
WDR47	O94967	799	872	840	879	Repeat	Note=WD 6
WDR47	O94967	53	80	54	81	Alternative sequence	ID=VSP_012093;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR47	O94967	698	755	698	698	Sequence conflict	Note=T->TVS;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR47	O94967	755	799	779	779	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR47	O94967	755	799	789	789	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR25	Q64LD2	424	471	1	544	Chain	ID=PRO_0000256227;Note=WD repeat-containing protein 25
WDR25	Q64LD2	424	471	1	544	Chain	ID=PRO_0000256227;Note=WD repeat-containing protein 25
WDR25	Q64LD2	424	471	1	544	Chain	ID=PRO_0000256227;Note=WD repeat-containing protein 25
WDR25	Q64LD2	424	471	424	463	Repeat	Note=WD 5
WDR25	Q64LD2	424	471	424	463	Repeat	Note=WD 5
WDR25	Q64LD2	424	471	424	463	Repeat	Note=WD 5
WDR25	Q64LD2	424	471	469	510	Repeat	Note=WD 6
WDR25	Q64LD2	424	471	469	510	Repeat	Note=WD 6
WDR25	Q64LD2	424	471	469	510	Repeat	Note=WD 6
WDR25	Q64LD2	424	471	462	462	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR25	Q64LD2	424	471	462	462	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR25	Q64LD2	424	471	462	462	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR31	Q8NA23	83	108	1	367	Chain	ID=PRO_0000051380;Note=WD repeat-containing protein 31
WDR31	Q8NA23	83	108	53	90	Repeat	Note=WD 1
WDR31	Q8NA23	83	108	94	132	Repeat	Note=WD 2
WDR5	P61964	247	272	2	334	Chain	ID=PRO_0000051350;Note=WD repeat-containing protein 5
WDR5	P61964	247	272	212	253	Repeat	Note=WD 5
WDR5	P61964	247	272	256	296	Repeat	Note=WD 6
WDR5	P61964	247	272	263	263	Site	Note=Important for interaction with histone H3
WDR5	P61964	247	272	263	263	Mutagenesis	Note=Strongly reduced affinity for histone H3. F->A%2CW;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16829960;Dbxref=PMID:16829960
WDR5	P61964	247	272	247	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ERY
WDR5	P61964	247	272	258	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ERY
WDR5	P61964	247	272	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ERY
WDR5	P61964	247	272	269	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ERY
WRN	Q14191	168	218	2	1432	Chain	ID=PRO_0000205045;Note=Werner syndrome ATP-dependent helicase
WRN	Q14191	911	941	2	1432	Chain	ID=PRO_0000205045;Note=Werner syndrome ATP-dependent helicase
WRN	Q14191	168	218	60	228	Domain	Note=3'-5' exonuclease
WRN	Q14191	168	218	2	277	Region	Note=Interaction with WRNIP1;Ontology_term=ECO:0000250;evidence=ECO:0000250
WRN	Q14191	168	218	216	216	Metal binding	Note=Magnesium 1%3B catalytic;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2FBV,ECO:0000244|PDB:2FBX,ECO:0000244|PDB:2FC0,ECO:0000269|PubMed:16622405;Dbxref=PMID:16622405
WRN	Q14191	168	218	172	172	Natural variant	ID=VAR_017455;Note=Polymorphism%3B no effect on exonuclease activity. T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11161804,ECO:0000269|PubMed:16622405;Dbxref=dbSNP:rs367991517,PMID:11161804,PMID:16622405
WRN	Q14191	911	941	912	912	Natural variant	ID=VAR_018945;Note=I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs11574323
WRN	Q14191	168	218	212	212	Mutagenesis	Note=Strongly reduces exonuclease activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16622405;Dbxref=PMID:16622405
WRN	Q14191	168	218	161	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FBY
WRN	Q14191	168	218	177	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FBY
WRN	Q14191	168	218	193	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FBY
WRN	Q14191	168	218	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FBY
WRN	Q14191	168	218	207	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FBY
WRAP73	Q9P2S5	307	349	1	460	Chain	ID=PRO_0000051356;Note=WD repeat-containing protein WRAP73
WRAP73	Q9P2S5	201	246	1	460	Chain	ID=PRO_0000051356;Note=WD repeat-containing protein WRAP73
WRAP73	Q9P2S5	172	201	1	460	Chain	ID=PRO_0000051356;Note=WD repeat-containing protein WRAP73
WRAP73	Q9P2S5	23	74	1	460	Chain	ID=PRO_0000051356;Note=WD repeat-containing protein WRAP73
WRAP73	Q9P2S5	23	74	46	86	Repeat	Note=WD 1
WRAP73	Q9P2S5	201	246	176	210	Repeat	Note=WD 3
WRAP73	Q9P2S5	172	201	176	210	Repeat	Note=WD 3
WRAP73	Q9P2S5	201	246	221	260	Repeat	Note=WD 4
WRAP73	Q9P2S5	307	349	328	369	Repeat	Note=WD 5
WRAP73	Q9P2S5	307	349	331	331	Natural variant	ID=VAR_057624;Note=I->M;Dbxref=dbSNP:rs2760320
WWP1	Q9H0M0	111	157	1	922	Chain	ID=PRO_0000120336;Note=NEDD4-like E3 ubiquitin-protein ligase WWP1
WWP1	Q9H0M0	559	583	1	922	Chain	ID=PRO_0000120336;Note=NEDD4-like E3 ubiquitin-protein ligase WWP1
WWP1	Q9H0M0	111	157	1	922	Chain	ID=PRO_0000120336;Note=NEDD4-like E3 ubiquitin-protein ligase WWP1
WWP1	Q9H0M0	559	583	1	922	Chain	ID=PRO_0000120336;Note=NEDD4-like E3 ubiquitin-protein ligase WWP1
WWP1	Q9H0M0	111	157	23	240	Alternative sequence	ID=VSP_007600;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	23	240	Alternative sequence	ID=VSP_007600;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	112	242	Alternative sequence	ID=VSP_007602;Note=In isoform 3. LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTV->F;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	112	242	Alternative sequence	ID=VSP_007602;Note=In isoform 3. LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTV->F;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	112	120	Alternative sequence	ID=VSP_007601;Note=In isoform 2. LERVKEQLK->CWLLKARME;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	112	120	Alternative sequence	ID=VSP_007601;Note=In isoform 2. LERVKEQLK->CWLLKARME;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	121	922	Alternative sequence	ID=VSP_007603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	559	583	121	922	Alternative sequence	ID=VSP_007603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	111	157	121	922	Alternative sequence	ID=VSP_007603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	559	583	121	922	Alternative sequence	ID=VSP_007603;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11779188;Dbxref=PMID:11779188
WWP1	Q9H0M0	559	583	547	559	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HPS
WWP1	Q9H0M0	559	583	547	559	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HPS
WWP1	Q9H0M0	559	583	564	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HPS
WWP1	Q9H0M0	559	583	564	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HPS
WWP1	Q9H0M0	559	583	573	575	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND7
WWP1	Q9H0M0	559	583	573	575	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ND7
WWP1	Q9H0M0	559	583	576	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HPS
WWP1	Q9H0M0	559	583	576	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HPS
XRCC1	P18887	48	85	1	633	Chain	ID=PRO_0000066044;Note=DNA repair protein XRCC1
XRCC1	P18887	48	85	72	72	Natural variant	ID=VAR_016168;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs25496
XRCC1	P18887	48	85	41	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LQC
XRCC1	P18887	48	85	57	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LQC
XRCC1	P18887	48	85	66	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LQC
XRCC1	P18887	48	85	75	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XNA
XRCC1	P18887	48	85	81	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LQC
XRCC1	P18887	48	85	85	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LQC
XRCC5	P13010	7	45	2	732	Chain	ID=PRO_0000084340;Note=X-ray repair cross-complementing protein 5
XRCC5	P13010	164	227	2	732	Chain	ID=PRO_0000084340;Note=X-ray repair cross-complementing protein 5
XRCC5	P13010	7	45	2	732	Chain	ID=PRO_0000084340;Note=X-ray repair cross-complementing protein 5
XRCC5	P13010	164	227	2	732	Chain	ID=PRO_0000084340;Note=X-ray repair cross-complementing protein 5
XRCC5	P13010	164	227	138	165	Region	Note=Leucine-zipper
XRCC5	P13010	164	227	138	165	Region	Note=Leucine-zipper
XRCC5	P13010	164	227	195	195	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
XRCC5	P13010	164	227	195	195	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
XRCC5	P13010	7	45	14	16	Sequence conflict	Note=MDV->YSY;Ontology_term=ECO:0000305;evidence=ECO:0000305
XRCC5	P13010	7	45	14	16	Sequence conflict	Note=MDV->YSY;Ontology_term=ECO:0000305;evidence=ECO:0000305
XRCC5	P13010	164	227	178	178	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
XRCC5	P13010	164	227	178	178	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
XRCC5	P13010	7	45	8	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	7	45	8	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	7	45	18	21	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	7	45	18	21	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	7	45	30	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	7	45	30	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	159	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	159	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	194	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	194	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	199	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	199	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	218	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	218	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	224	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	224	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	227	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC5	P13010	164	227	227	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRN2	Q9H0D6	286	311	1	950	Chain	ID=PRO_0000071396;Note=5'-3' exoribonuclease 2
XRN2	Q9H0D6	375	411	1	950	Chain	ID=PRO_0000071396;Note=5'-3' exoribonuclease 2
XRN2	Q9H0D6	591	621	1	950	Chain	ID=PRO_0000071396;Note=5'-3' exoribonuclease 2
XRN2	Q9H0D6	733	751	1	950	Chain	ID=PRO_0000071396;Note=5'-3' exoribonuclease 2
XRN2	Q9H0D6	286	311	286	286	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBR1
XRN2	Q9H0D6	733	751	743	743	Natural variant	ID=VAR_027516;Note=R->M;Dbxref=dbSNP:rs6137324
XRN2	Q9H0D6	733	751	737	737	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
XRRA1	Q6P2D8	340	382	1	792	Chain	ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1
XRRA1	Q6P2D8	93	109	1	792	Chain	ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1
XRRA1	Q6P2D8	93	109	104	125	Repeat	Note=LRR 1
XRRA1	Q6P2D8	93	109	1	233	Alternative sequence	ID=VSP_044988;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRRA1	Q6P2D8	340	382	327	413	Alternative sequence	ID=VSP_052670;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRRA1	Q6P2D8	340	382	327	382	Alternative sequence	ID=VSP_052671;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
XRRA1	Q6P2D8	340	382	327	340	Alternative sequence	ID=VSP_052672;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12908878;Dbxref=PMID:12908878
XRRA1	Q6P2D8	340	382	341	382	Alternative sequence	ID=VSP_044989;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRRA1	Q6P2D8	340	382	356	356	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAM20B	O75063	126	154	1	409	Chain	ID=PRO_0000008745;Note=Glycosaminoglycan xylosylkinase
FAM20B	O75063	313	332	1	409	Chain	ID=PRO_0000008745;Note=Glycosaminoglycan xylosylkinase
FAM20B	O75063	126	154	26	409	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM20B	O75063	313	332	26	409	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM20B	O75063	126	154	142	142	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9XTW2
FAM20B	O75063	313	332	257	331	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9XTW2
FAM20B	O75063	313	332	332	389	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9XTW2
VPS54	Q9P1Q0	848	875	1	977	Chain	ID=PRO_0000148731;Note=Vacuolar protein sorting-associated protein 54
VPS54	Q9P1Q0	379	415	1	977	Chain	ID=PRO_0000148731;Note=Vacuolar protein sorting-associated protein 54
VPS54	Q9P1Q0	164	208	1	977	Chain	ID=PRO_0000148731;Note=Vacuolar protein sorting-associated protein 54
VPS54	Q9P1Q0	379	415	1	838	Alternative sequence	ID=VSP_013751;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
VPS54	Q9P1Q0	164	208	1	838	Alternative sequence	ID=VSP_013751;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
VPS54	Q9P1Q0	379	415	380	415	Alternative sequence	ID=VSP_013755;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR73	Q6P4I2	172	294	1	378	Chain	ID=PRO_0000307280;Note=WD repeat-containing protein 73
WDR73	Q6P4I2	172	294	167	205	Repeat	Note=WD 3
WDR73	Q6P4I2	172	294	214	255	Repeat	Note=WD 4
WDR73	Q6P4I2	172	294	266	305	Repeat	Note=WD 5
WDR73	Q6P4I2	172	294	249	249	Natural variant	ID=VAR_035399;Note=R->H;Dbxref=dbSNP:rs11073619
WDR73	Q6P4I2	172	294	224	224	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
WAS	P42768	91	120	2	502	Chain	ID=PRO_0000188990;Note=Wiskott-Aldrich syndrome protein
WAS	P42768	91	120	39	148	Domain	Note=WH1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00410
WAS	P42768	91	120	97	97	Natural variant	ID=VAR_005833;Note=In WAS%3B attenuated form. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8528198;Dbxref=PMID:8528198
WDR75	Q8IWA0	574	606	1	830	Chain	ID=PRO_0000051430;Note=WD repeat-containing protein 75
WDR75	Q8IWA0	574	606	574	611	Repeat	Note=WD 13
WDFY4	Q6ZS81	1835	1903	1	3184	Chain	ID=PRO_0000251254;Note=WD repeat- and FYVE domain-containing protein 4
WDFY4	Q6ZS81	2113	2175	1	3184	Chain	ID=PRO_0000251254;Note=WD repeat- and FYVE domain-containing protein 4
WDFY4	Q6ZS81	2508	2528	1	3184	Chain	ID=PRO_0000251254;Note=WD repeat- and FYVE domain-containing protein 4
WDFY4	Q6ZS81	2508	2528	2385	2510	Domain	Note=BEACH-type PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01119
WDFY4	Q6ZS81	2508	2528	2527	2821	Domain	Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026
WDFY4	Q6ZS81	1835	1903	655	3184	Alternative sequence	ID=VSP_020751;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDFY4	Q6ZS81	2113	2175	655	3184	Alternative sequence	ID=VSP_020751;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDFY4	Q6ZS81	2508	2528	655	3184	Alternative sequence	ID=VSP_020751;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDFY4	Q6ZS81	1835	1903	1043	3184	Alternative sequence	ID=VSP_035684;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDFY4	Q6ZS81	2113	2175	1043	3184	Alternative sequence	ID=VSP_035684;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDFY4	Q6ZS81	2508	2528	1043	3184	Alternative sequence	ID=VSP_035684;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDFY4	Q6ZS81	2508	2528	2527	2527	Natural variant	ID=VAR_047261;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2663046,PMID:10997877,PMID:15489334
WFDC1	Q9HC57	112	140	32	220	Chain	ID=PRO_0000041365;Note=WAP four-disulfide core domain protein 1
WFDC1	Q9HC57	187	201	32	220	Chain	ID=PRO_0000041365;Note=WAP four-disulfide core domain protein 1
WFDC1	Q9HC57	112	140	32	220	Chain	ID=PRO_0000041365;Note=WAP four-disulfide core domain protein 1
WFDC1	Q9HC57	187	201	32	220	Chain	ID=PRO_0000041365;Note=WAP four-disulfide core domain protein 1
WFDC1	Q9HC57	112	140	109	112	Compositional bias	Note=Poly-Pro
WFDC1	Q9HC57	112	140	109	112	Compositional bias	Note=Poly-Pro
WFDC1	Q9HC57	112	140	138	138	Natural variant	ID=VAR_036489;Note=In a breast cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs11643870,PMID:16959974
WFDC1	Q9HC57	112	140	138	138	Natural variant	ID=VAR_036489;Note=In a breast cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs11643870,PMID:16959974
WFDC1	Q9HC57	187	201	196	196	Natural variant	ID=VAR_052948;Note=L->V;Dbxref=dbSNP:rs35504166
WFDC1	Q9HC57	187	201	196	196	Natural variant	ID=VAR_052948;Note=L->V;Dbxref=dbSNP:rs35504166
WIF1	Q9Y5W5	307	339	29	379	Chain	ID=PRO_0000007775;Note=Wnt inhibitory factor 1
WIF1	Q9Y5W5	275	307	29	379	Chain	ID=PRO_0000007775;Note=Wnt inhibitory factor 1
WIF1	Q9Y5W5	243	275	29	379	Chain	ID=PRO_0000007775;Note=Wnt inhibitory factor 1
WIF1	Q9Y5W5	211	243	29	379	Chain	ID=PRO_0000007775;Note=Wnt inhibitory factor 1
WIF1	Q9Y5W5	211	243	211	242	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	243	275	243	271	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	211	243	243	271	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	275	307	274	306	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	243	275	274	306	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	307	339	307	338	Domain	Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	275	307	307	338	Domain	Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
WIF1	Q9Y5W5	243	275	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
WIF1	Q9Y5W5	211	243	214	224	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	211	243	218	230	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	211	243	232	241	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	243	275	246	256	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	243	275	250	262	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	275	307	278	288	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	275	307	282	294	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	275	307	296	305	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	307	339	310	320	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	307	339	314	326	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WIF1	Q9Y5W5	307	339	328	337	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WWC3	Q9ULE0	244	324	1	1092	Chain	ID=PRO_0000244494;Note=Protein WWC3
WWC3	Q9ULE0	702	760	1	1092	Chain	ID=PRO_0000244494;Note=Protein WWC3
WWC3	Q9ULE0	702	760	617	706	Domain	Note=C2
WWC3	Q9ULE0	244	324	230	344	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
WWC3	Q9ULE0	702	760	583	1092	Alternative sequence	ID=VSP_029221;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
XYLB	O75191	70	97	1	536	Chain	ID=PRO_0000230985;Note=Xylulose kinase
XYLB	O75191	169	191	1	536	Chain	ID=PRO_0000230985;Note=Xylulose kinase
XYLB	O75191	169	191	170	170	Binding site	Note=Substrate
XYLB	O75191	70	97	1	137	Alternative sequence	ID=VSP_055522;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
XYLB	O75191	70	97	85	85	Natural variant	ID=VAR_055151;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9763671,ECO:0000269|Ref.3;Dbxref=dbSNP:rs17118,PMID:14702039,PMID:9763671
XYLB	O75191	70	97	65	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BC3
XYLB	O75191	70	97	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BC3
XYLB	O75191	70	97	89	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BC3
XYLB	O75191	169	191	172	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BC3
XYLB	O75191	169	191	184	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BC3
XYLB	O75191	169	191	190	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BC3
YAF2	Q8IY57	9	50	1	180	Chain	ID=PRO_0000066113;Note=YY1-associated factor 2
YAF2	Q8IY57	9	50	19	48	Zinc finger	Note=RanBP2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00322
YAF2	Q8IY57	9	50	8	49	Alternative sequence	ID=VSP_043415;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YAF2	Q8IY57	9	50	50	50	Alternative sequence	ID=VSP_055659;Note=In isoform 2. T->TRSTLFEVIVSASRTKEPLKFPISG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
YAF2	Q8IY57	9	50	13	14	Sequence conflict	Note=QP->HA;Ontology_term=ECO:0000305;evidence=ECO:0000305
YAF2	Q8IY57	9	50	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9G
YAF2	Q8IY57	9	50	40	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9G
YBX1	P67809	88	118	2	324	Chain	ID=PRO_0000100219;Note=Nuclease-sensitive element-binding protein 1
YBX1	P67809	118	219	2	324	Chain	ID=PRO_0000100219;Note=Nuclease-sensitive element-binding protein 1
YBX1	P67809	88	118	61	125	Domain	Note=CSD
YBX1	P67809	118	219	61	125	Domain	Note=CSD
YBX1	P67809	118	219	219	220	Site	Note=Cleavage%3B by 20S proteasomal protease
YBX1	P67809	88	118	102	102	Modified residue	Note=Phosphoserine%3B by PKB/AKT1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:15806160;Dbxref=PMID:19690332,PMID:15806160
YBX1	P67809	118	219	162	162	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
YBX1	P67809	118	219	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.6;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
YBX1	P67809	118	219	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
YBX1	P67809	118	219	174	174	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
YBX1	P67809	118	219	176	176	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
YBX1	P67809	118	219	137	137	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18851979;Dbxref=PMID:18851979
YBX1	P67809	88	118	102	102	Mutagenesis	Note=Loss of phosphorylation by PKB/AKT1. Inhibits translocation to the nucleus and tumor cell growth. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15806160;Dbxref=PMID:15806160
YBX1	P67809	118	219	120	120	Sequence conflict	Note=A->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
YBX1	P67809	88	118	88	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX1	P67809	88	118	108	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX1	P67809	88	118	117	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX1	P67809	118	219	117	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YKT6	O15498	96	131	1	195	Chain	ID=PRO_0000280709;Note=Synaptobrevin homolog YKT6
YKT6	O15498	131	153	1	195	Chain	ID=PRO_0000280709;Note=Synaptobrevin homolog YKT6
YKT6	O15498	153	187	1	195	Chain	ID=PRO_0000280709;Note=Synaptobrevin homolog YKT6
YKT6	O15498	96	131	8	126	Domain	Note=Longin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00231
YKT6	O15498	131	153	138	198	Domain	Note=v-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00290
YKT6	O15498	153	187	138	198	Domain	Note=v-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00290
YKT6	O15498	153	187	159	159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YKT6	O15498	153	187	154	187	Alternative sequence	ID=VSP_056071;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YKT6	O15498	131	153	138	138	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF2	Q9BWQ6	122	161	2	316	Chain	ID=PRO_0000241454;Note=Protein YIPF2
YIPF2	Q9BWQ6	64	93	2	316	Chain	ID=PRO_0000241454;Note=Protein YIPF2
YIPF2	Q9BWQ6	122	161	2	316	Chain	ID=PRO_0000241454;Note=Protein YIPF2
YIPF2	Q9BWQ6	64	93	2	316	Chain	ID=PRO_0000241454;Note=Protein YIPF2
YIPF2	Q9BWQ6	122	161	2	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27999994;Dbxref=PMID:27999994
YIPF2	Q9BWQ6	64	93	2	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27999994;Dbxref=PMID:27999994
YIPF2	Q9BWQ6	122	161	2	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27999994;Dbxref=PMID:27999994
YIPF2	Q9BWQ6	64	93	2	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27999994;Dbxref=PMID:27999994
YIPF2	Q9BWQ6	122	161	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF2	Q9BWQ6	122	161	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF2	Q9BWQ6	122	161	146	163	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF2	Q9BWQ6	122	161	146	163	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF3	Q9GZM5	222	260	2	350	Chain	ID=PRO_0000244446;Note=Protein YIPF3
YIPF3	Q9GZM5	178	222	2	350	Chain	ID=PRO_0000244446;Note=Protein YIPF3
YIPF3	Q9GZM5	147	178	2	350	Chain	ID=PRO_0000244446;Note=Protein YIPF3
YIPF3	Q9GZM5	147	178	2	148	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27999994;Dbxref=PMID:27999994
YIPF3	Q9GZM5	147	178	149	169	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF3	Q9GZM5	178	222	170	187	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF3	Q9GZM5	147	178	170	187	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF3	Q9GZM5	178	222	188	208	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF3	Q9GZM5	178	222	209	214	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF3	Q9GZM5	222	260	215	237	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF3	Q9GZM5	178	222	215	237	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF3	Q9GZM5	222	260	238	240	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF3	Q9GZM5	222	260	241	263	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF3	Q9GZM5	147	178	161	161	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF4	Q9BSR8	135	161	1	244	Chain	ID=PRO_0000242632;Note=Protein YIPF4
YIPF4	Q9BSR8	161	199	1	244	Chain	ID=PRO_0000242632;Note=Protein YIPF4
YIPF4	Q9BSR8	135	161	135	138	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF4	Q9BSR8	135	161	139	159	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF4	Q9BSR8	135	161	160	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF4	Q9BSR8	161	199	160	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF4	Q9BSR8	161	199	167	187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF4	Q9BSR8	161	199	188	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIPF4	Q9BSR8	161	199	196	216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YME1L1	Q96TA2	697	726	1	773	Chain	ID=PRO_0000084667;Note=ATP-dependent zinc metalloprotease YME1L1
YME1L1	Q96TA2	527	579	1	773	Chain	ID=PRO_0000084667;Note=ATP-dependent zinc metalloprotease YME1L1
YME1L1	Q96TA2	469	489	1	773	Chain	ID=PRO_0000084667;Note=ATP-dependent zinc metalloprotease YME1L1
YME1L1	Q96TA2	167	200	1	773	Chain	ID=PRO_0000084667;Note=ATP-dependent zinc metalloprotease YME1L1
YME1L1	Q96TA2	56	113	1	773	Chain	ID=PRO_0000084667;Note=ATP-dependent zinc metalloprotease YME1L1
YME1L1	Q96TA2	167	200	1	295	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
YME1L1	Q96TA2	56	113	1	295	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
YME1L1	Q96TA2	697	726	317	773	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27786171;Dbxref=PMID:27786171
YME1L1	Q96TA2	527	579	317	773	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27786171;Dbxref=PMID:27786171
YME1L1	Q96TA2	469	489	317	773	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27786171;Dbxref=PMID:27786171
YME1L1	Q96TA2	56	113	57	113	Alternative sequence	ID=VSP_010017;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10843804,ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10843804,PMID:12975309,PMID:14702039,PMID:15489334
YME1L1	Q96TA2	167	200	168	200	Alternative sequence	ID=VSP_045336;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AZGP1	P25311	112	204	21	298	Chain	ID=PRO_0000019012;Note=Zinc-alpha-2-glycoprotein
AZGP1	P25311	25	112	21	298	Chain	ID=PRO_0000019012;Note=Zinc-alpha-2-glycoprotein
AZGP1	P25311	25	112	109	109	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206894,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218;Dbxref=PMID:10206894,PMID:16740002,PMID:18780401,PMID:19139490,PMID:19159218
AZGP1	P25311	112	204	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218;Dbxref=PMID:14760718,PMID:16335952,PMID:16740002,PMID:18780401,PMID:19159218
AZGP1	P25311	25	112	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218;Dbxref=PMID:14760718,PMID:16335952,PMID:16740002,PMID:18780401,PMID:19159218
AZGP1	P25311	112	204	128	128	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10206894,ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:15477100,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:22171320;Dbxref=PMID:10206894,PMID:14760718,PMID:15084671,PMID:15477100,PMID:16740002,PMID:18780401,PMID:19139490,PMID:19159218,PMID:22171320
AZGP1	P25311	112	204	123	186	Disulfide bond	.
AZGP1	P25311	25	112	33	33	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AZGP1	P25311	25	112	85	85	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
AZGP1	P25311	25	112	96	97	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
AZGP1	P25311	25	112	27	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	25	112	42	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZAG
AZGP1	P25311	25	112	46	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	25	112	56	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	25	112	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	25	112	72	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	25	112	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ES6
AZGP1	P25311	25	112	83	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	116	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	129	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	142	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	149	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	153	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	159	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	173	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	185	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
AZGP1	P25311	112	204	198	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T7V
ZBP1	Q9H171	223	291	1	429	Chain	ID=PRO_0000066564;Note=Z-DNA-binding protein 1
ZBP1	Q9H171	223	291	253	277	Motif	Note=RIP homotypic interaction motif (RHIM) 2
ZBP1	Q9H171	223	291	150	429	Alternative sequence	ID=VSP_004080;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZBP1	Q9H171	223	291	225	248	Alternative sequence	ID=VSP_045405;Note=In isoform 6. SAGPRHLPSMAPGDSSTWGTLVDP->KSPKRAQGGDLGGEPPDPLGGGKG;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
ZBP1	Q9H171	223	291	249	429	Alternative sequence	ID=VSP_045406;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
ZBP1	Q9H171	223	291	258	258	Natural variant	ID=VAR_069138;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11842111,ECO:0000269|PubMed:14702039,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2865394,PMID:11842111,PMID:14702039
ZBTB46	Q86UZ6	312	407	1	589	Chain	ID=PRO_0000047746;Note=Zinc finger and BTB domain-containing protein 46
ZBTB46	Q86UZ6	312	407	1	589	Chain	ID=PRO_0000047746;Note=Zinc finger and BTB domain-containing protein 46
ZBTB46	Q86UZ6	312	407	1	589	Chain	ID=PRO_0000047746;Note=Zinc finger and BTB domain-containing protein 46
ZDHHC13	Q8IUH4	249	291	1	622	Chain	ID=PRO_0000212887;Note=Palmitoyltransferase ZDHHC13
ZDHHC13	Q8IUH4	463	491	1	622	Chain	ID=PRO_0000212887;Note=Palmitoyltransferase ZDHHC13
ZDHHC13	Q8IUH4	463	491	471	491	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC13	Q8IUH4	249	291	249	277	Repeat	Note=ANK 7;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC13	Q8IUH4	463	491	426	476	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC13	Q8IUH4	463	491	467	467	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZDHHC23	Q8IYP9	291	346	1	409	Chain	ID=PRO_0000212912;Note=Palmitoyltransferase ZDHHC23
ZDHHC23	Q8IYP9	291	346	303	323	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZDHHC23	Q8IYP9	291	346	259	309	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZC3H11A	O75152	18	58	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	206	233	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	233	270	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	270	291	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	291	324	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	324	347	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	347	515	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	18	58	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	206	233	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	233	270	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	270	291	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	291	324	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	324	347	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	347	515	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	18	58	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	206	233	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	233	270	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	270	291	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	291	324	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	324	347	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	347	515	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	18	58	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	206	233	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	233	270	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	270	291	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	291	324	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	324	347	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	347	515	1	810	Chain	ID=PRO_0000213905;Note=Zinc finger CCCH domain-containing protein 11A
ZC3H11A	O75152	18	58	2	29	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	2	29	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	2	29	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	2	29	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	31	57	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	31	57	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	31	57	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	18	58	31	57	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZC3H11A	O75152	347	515	362	423	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZC3H11A	O75152	347	515	362	423	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZC3H11A	O75152	347	515	362	423	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZC3H11A	O75152	347	515	362	423	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZC3H11A	O75152	270	291	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
ZC3H11A	O75152	270	291	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
ZC3H11A	O75152	270	291	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
ZC3H11A	O75152	270	291	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
ZC3H11A	O75152	291	324	321	321	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ZC3H11A	O75152	291	324	321	321	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ZC3H11A	O75152	291	324	321	321	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ZC3H11A	O75152	291	324	321	321	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ZC3H11A	O75152	347	515	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3H11A	O75152	347	515	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3H11A	O75152	347	515	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3H11A	O75152	347	515	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3H11A	O75152	347	515	478	478	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
ZC3H11A	O75152	347	515	478	478	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
ZC3H11A	O75152	347	515	478	478	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
ZC3H11A	O75152	347	515	478	478	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
ZC3H11A	O75152	233	270	246	246	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	246	246	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	246	246	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	246	246	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	266	266	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	266	266	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	266	266	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	233	270	266	266	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	270	291	277	277	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	270	291	277	277	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	270	291	277	277	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	270	291	277	277	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	409	409	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	409	409	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	409	409	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	409	409	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	412	412	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	412	412	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	412	412	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H11A	O75152	347	515	412	412	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZCCHC2	Q9C0B9	376	400	1	1178	Chain	ID=PRO_0000150949;Note=Zinc finger CCHC domain-containing protein 2
ZCCHC2	Q9C0B9	469	497	1	1178	Chain	ID=PRO_0000150949;Note=Zinc finger CCHC domain-containing protein 2
ZCCHC2	Q9C0B9	615	658	1	1178	Chain	ID=PRO_0000150949;Note=Zinc finger CCHC domain-containing protein 2
HIVEP1	P15822	13	31	1	2718	Chain	ID=PRO_0000047369;Note=Zinc finger protein 40
HIVEP1	P15822	2128	2162	1	2718	Chain	ID=PRO_0000047369;Note=Zinc finger protein 40
HIVEP1	P15822	2128	2162	2116	2140	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
HIVEP1	P15822	13	31	1	2017	Alternative sequence	ID=VSP_037714;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HIVEP1	P15822	13	31	1	2002	Alternative sequence	ID=VSP_037715;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
HIVEP1	P15822	2128	2162	2149	2149	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
HIVEP1	P15822	2128	2162	2128	2136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BBO
HIVEP1	P15822	2128	2162	2137	2140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BBO
ZFYVE16	Q7Z3T8	1230	1265	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1314	1341	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1431	1487	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1230	1265	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1314	1341	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1431	1487	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1230	1265	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1314	1341	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1431	1487	1	1539	Chain	ID=PRO_0000098716;Note=Zinc finger FYVE domain-containing protein 16
ZFYVE16	Q7Z3T8	1230	1265	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1314	1341	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1431	1487	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1230	1265	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1314	1341	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1431	1487	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1230	1265	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1314	1341	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE16	Q7Z3T8	1431	1487	810	1539	Alternative sequence	ID=VSP_011020;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFAND6	Q6FIF0	121	159	1	208	Chain	ID=PRO_0000245235;Note=AN1-type zinc finger protein 6
ZFAND6	Q6FIF0	121	159	1	208	Chain	ID=PRO_0000245235;Note=AN1-type zinc finger protein 6
ZFAND6	Q6FIF0	121	159	1	208	Chain	ID=PRO_0000245235;Note=AN1-type zinc finger protein 6
ZFAND6	Q6FIF0	121	159	1	208	Chain	ID=PRO_0000245235;Note=AN1-type zinc finger protein 6
ZFAND6	Q6FIF0	121	159	1	208	Chain	ID=PRO_0000245235;Note=AN1-type zinc finger protein 6
ZFAND6	Q6FIF0	121	159	1	208	Chain	ID=PRO_0000245235;Note=AN1-type zinc finger protein 6
ZFAND6	Q6FIF0	121	159	146	189	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND6	Q6FIF0	121	159	146	189	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND6	Q6FIF0	121	159	146	189	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND6	Q6FIF0	121	159	146	189	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND6	Q6FIF0	121	159	146	189	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND6	Q6FIF0	121	159	146	189	Zinc finger	Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	138	138	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	140	140	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	140	140	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	140	140	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	140	140	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	140	140	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZFAND6	Q6FIF0	121	159	140	140	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
YES1	P07947	430	474	2	543	Chain	ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes
YES1	P07947	124	156	2	543	Chain	ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes
YES1	P07947	430	474	2	543	Chain	ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes
YES1	P07947	124	156	2	543	Chain	ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes
YES1	P07947	124	156	91	152	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
YES1	P07947	124	156	91	152	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
YES1	P07947	430	474	277	530	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
YES1	P07947	430	474	277	530	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
YES1	P07947	430	474	446	446	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305
YES1	P07947	430	474	446	446	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305
YES1	P07947	124	156	126	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	126	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	134	136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	139	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	139	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	147	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YES1	P07947	124	156	147	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA
YTHDC1	Q96MU7	587	608	1	727	Chain	ID=PRO_0000223076;Note=YTH domain-containing protein 1
YTHDC1	Q96MU7	324	342	1	727	Chain	ID=PRO_0000223076;Note=YTH domain-containing protein 1
YTHDC1	Q96MU7	587	608	601	643	Compositional bias	Note=Pro-rich
YTHDC1	Q96MU7	324	342	325	342	Alternative sequence	ID=VSP_006818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
YTHDC2	Q9H6S0	774	814	1	1430	Chain	ID=PRO_0000249340;Note=3'-5' RNA helicase YTHDC2
YTHDC2	Q9H6S0	774	814	612	784	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
YIPF1	Q9Y548	216	277	1	306	Chain	ID=PRO_0000240868;Note=Protein YIPF1
YIPF1	Q9Y548	121	160	1	306	Chain	ID=PRO_0000240868;Note=Protein YIPF1
YIPF1	Q9Y548	121	160	120	140	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF1	Q9Y548	121	160	141	162	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27999994;Dbxref=PMID:27999994
YIPF1	Q9Y548	216	277	201	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF1	Q9Y548	216	277	222	227	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27999994;Dbxref=PMID:27999994
YIPF1	Q9Y548	216	277	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF1	Q9Y548	216	277	249	256	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27999994;Dbxref=PMID:27999994
YIPF1	Q9Y548	216	277	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIPF1	Q9Y548	121	160	1	183	Alternative sequence	ID=VSP_019437;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZC3HAV1	Q7Z2W4	232	490	2	902	Chain	ID=PRO_0000211343;Note=Zinc finger CCCH-type antiviral protein 1
ZC3HAV1	Q7Z2W4	232	490	2	254	Region	Note=N-terminal domain
ZC3HAV1	Q7Z2W4	232	490	224	254	Region	Note=Binding to EXOSC5;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZC3HAV1	Q7Z2W4	232	490	285	292	Motif	Note=Nuclear export signal;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZC3HAV1	Q7Z2W4	232	490	257	257	Modified residue	Note=Phosphoserine%3B by GSK3-beta;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	263	263	Modified residue	Note=Phosphoserine%3B by GSK3-beta;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K3Y6
ZC3HAV1	Q7Z2W4	232	490	267	267	Modified residue	Note=Phosphoserine%3B by GSK3-beta;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K3Y6
ZC3HAV1	Q7Z2W4	232	490	271	271	Modified residue	Note=Phosphoserine%3B by GSK3-beta;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ZC3HAV1	Q7Z2W4	232	490	273	273	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	275	275	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
ZC3HAV1	Q7Z2W4	232	490	284	284	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17081983,PMID:18220336,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
ZC3HAV1	Q7Z2W4	232	490	302	302	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	327	327	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UPF5
ZC3HAV1	Q7Z2W4	232	490	335	335	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	355	355	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	378	378	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	387	387	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
ZC3HAV1	Q7Z2W4	232	490	393	393	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	469	469	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZC3HAV1	Q7Z2W4	232	490	1	539	Alternative sequence	ID=VSP_010268;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
ZC3HAV1	Q7Z2W4	232	490	485	485	Natural variant	ID=VAR_018454;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2236426,PMID:14702039
ZC3HAV1	Q7Z2W4	232	490	245	245	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZC3H4	Q9UPT8	715	799	1	1303	Chain	ID=PRO_0000234068;Note=Zinc finger CCCH domain-containing protein 4
ZC3H4	Q9UPT8	127	164	1	1303	Chain	ID=PRO_0000234068;Note=Zinc finger CCCH domain-containing protein 4
ZC3H4	Q9UPT8	127	164	95	128	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZC3H4	Q9UPT8	715	799	767	800	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZC3H4	Q9UPT8	127	164	155	155	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ZC3H18	Q86VM9	598	632	1	953	Chain	ID=PRO_0000311242;Note=Zinc finger CCCH domain-containing protein 18
ZC3H18	Q86VM9	681	702	1	953	Chain	ID=PRO_0000311242;Note=Zinc finger CCCH domain-containing protein 18
ZC3H18	Q86VM9	598	632	532	746	Compositional bias	Note=Ser-rich
ZC3H18	Q86VM9	681	702	532	746	Compositional bias	Note=Ser-rich
ZC3H18	Q86VM9	598	632	622	622	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
ZC3H18	Q86VM9	681	702	683	953	Alternative sequence	ID=VSP_029455;Note=In isoform 2. TLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLSPQSKSSSKVTSVPGKASDPGAASTKSGKASTLSRREELLKQLKAVEDAIARKRAKIPGKA->LIKEAGSAMNHQTRTGRALLQPSGPTHPQTEVLGTGSQVGDWAPRSQSGREARTPKPLQPRLTGSASCHPSPRAPARSRACPAKPRIPAPPAPNQGRPARCLGGRSC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZCCHC24	Q8N2G6	149	204	1	241	Chain	ID=PRO_0000274289;Note=Zinc finger CCHC domain-containing protein 24
ZCCHC24	Q8N2G6	149	204	132	149	Zinc finger	Note=CCHC-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047
ZCCHC24	Q8N2G6	149	204	152	152	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZMAT4	Q9H898	116	192	1	229	Chain	ID=PRO_0000298916;Note=Zinc finger matrin-type protein 4
ZMAT4	Q9H898	116	192	145	175	Zinc finger	Note=Matrin-type 3
ZMAT4	Q9H898	116	192	117	192	Alternative sequence	ID=VSP_027476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF317	Q96PQ6	96	128	1	595	Chain	ID=PRO_0000047526;Note=Zinc finger protein 317
ZNF317	Q96PQ6	96	128	57	128	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF317	Q96PQ6	96	128	97	128	Alternative sequence	ID=VSP_006916;Note=In isoform 1 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11688974,ECO:0000303|PubMed:15489334;Dbxref=PMID:10997877,PMID:11688974,PMID:15489334
ZNF202	O95125	277	317	1	648	Chain	ID=PRO_0000047450;Note=Zinc finger protein 202
ZNF202	O95125	277	317	1	648	Chain	ID=PRO_0000047450;Note=Zinc finger protein 202
ZNF202	O95125	277	317	1	648	Chain	ID=PRO_0000047450;Note=Zinc finger protein 202
ZNF202	O95125	277	317	237	308	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF202	O95125	277	317	237	308	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF202	O95125	277	317	237	308	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF202	O95125	277	317	278	278	Sequence conflict	Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF202	O95125	277	317	278	278	Sequence conflict	Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF202	O95125	277	317	278	278	Sequence conflict	Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC7A6	Q92536	174	216	1	515	Chain	ID=PRO_0000341477;Note=Y+L amino acid transporter 2
SLC7A6	Q92536	174	216	1	515	Chain	ID=PRO_0000341477;Note=Y+L amino acid transporter 2
SLC7A6	Q92536	174	216	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	189	194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	189	194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	195	215	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	195	215	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	216	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC7A6	Q92536	174	216	216	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNF385A	Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
ZNF385A	Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
ZNF385A	Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
ZNF385A	Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
ZNF385A	Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
ZNF385A	Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
ZNF385A	Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF385A	Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF385A	Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF385A	Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
ZNF385A	Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
ZNF385A	Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
ZBBX	A8MT70	176	229	1	800	Chain	ID=PRO_0000325813;Note=Zinc finger B-box domain-containing protein 1
ZBBX	A8MT70	176	229	178	178	Natural variant	ID=VAR_048402;Note=K->R;Dbxref=dbSNP:rs11923054
ZFC3H1	O60293	1752	1786	2	1989	Chain	ID=PRO_0000286103;Note=Zinc finger C3H1 domain-containing protein
ZFC3H1	O60293	1752	1786	1745	1778	Repeat	Note=TPR 7
ZFC3H1	O60293	1752	1786	347	1989	Alternative sequence	ID=VSP_024993;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZBTB16	Q05516	455	484	1	673	Chain	ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16
ZBTB16	Q05516	455	484	1	673	Chain	ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16
ZBTB16	Q05516	455	484	461	483	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB16	Q05516	455	484	461	483	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB17	Q13105	609	679	1	803	Chain	ID=PRO_0000047730;Note=Zinc finger and BTB domain-containing protein 17
ZBTB17	Q13105	68	131	1	803	Chain	ID=PRO_0000047730;Note=Zinc finger and BTB domain-containing protein 17
ZBTB17	Q13105	68	131	1	104	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ZBTB17	Q13105	609	679	614	637	Zinc finger	Note=C2H2-type 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB17	Q13105	609	679	637	803	Region	Note=Interaction with HCFC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244100;Dbxref=PMID:12244100
ZBTB17	Q13105	609	679	637	718	Region	Note=Interaction with MYC
ZBTB17	Q13105	68	131	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZBTB17	Q13105	68	131	1	131	Alternative sequence	ID=VSP_044564;Note=In isoform 3. MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATE->MMCWPWPLSSKCRTSSRPAMPSSHLLSRLPALGEMRRPWPQKVCPVPSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZBTB17	Q13105	609	679	679	679	Alternative sequence	ID=VSP_013424;Note=In isoform 2. T->TGPATLPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZBTB17	Q13105	68	131	73	73	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB17	Q13105	68	131	67	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q81
ZBTB17	Q13105	68	131	80	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U2M
ZBTB17	Q13105	68	131	86	88	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q81
ZBTB17	Q13105	68	131	89	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q81
ZBTB17	Q13105	68	131	102	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q81
ZCCHC14	Q8WYQ9	397	444	1	949	Chain	ID=PRO_0000150975;Note=Zinc finger CCHC domain-containing protein 14
ZCCHC14	Q8WYQ9	397	444	420	425	Compositional bias	Note=Poly-Ser
ZDHHC20	Q5W0Z9	147	157	1	365	Chain	ID=PRO_0000212906;Note=Palmitoyltransferase ZDHHC20
ZDHHC20	Q5W0Z9	147	157	1	365	Chain	ID=PRO_0000212906;Note=Palmitoyltransferase ZDHHC20
ZDHHC20	Q5W0Z9	147	157	75	169	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	75	169	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	126	176	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC20	Q5W0Z9	147	157	126	176	Domain	Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067
ZDHHC20	Q5W0Z9	147	157	156	156	Active site	Note=S-palmitoyl cysteine intermediate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	156	156	Active site	Note=S-palmitoyl cysteine intermediate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	148	148	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BMN,ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	148	148	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BMN,ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	155	155	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BMN,ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	155	155	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BMN,ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	131	365	Alternative sequence	ID=VSP_016277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZDHHC20	Q5W0Z9	147	157	131	365	Alternative sequence	ID=VSP_016277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZDHHC20	Q5W0Z9	147	157	153	153	Mutagenesis	Note=Loss of catalytic activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	153	153	Mutagenesis	Note=Loss of catalytic activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	154	154	Mutagenesis	Note=Loss of catalytic activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	154	154	Mutagenesis	Note=Loss of catalytic activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	156	156	Mutagenesis	Note=Loss of catalytic activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	156	156	Mutagenesis	Note=Loss of catalytic activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29326245;Dbxref=PMID:29326245
ZDHHC20	Q5W0Z9	147	157	147	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BMN
ZDHHC20	Q5W0Z9	147	157	147	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BMN
ZDHHC20	Q5W0Z9	147	157	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BMN
ZDHHC20	Q5W0Z9	147	157	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BMN
ZDHHC20	Q5W0Z9	147	157	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BMN
ZDHHC20	Q5W0Z9	147	157	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BMN
ZBTB20	Q9HC78	66	601	1	741	Chain	ID=PRO_0000047733;Note=Zinc finger and BTB domain-containing protein 20
ZBTB20	Q9HC78	66	601	104	167	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ZBTB20	Q9HC78	66	601	578	600	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB20	Q9HC78	66	601	211	211	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ZBTB20	Q9HC78	66	601	353	353	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ZBTB20	Q9HC78	66	601	357	357	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K0L9
ZBTB20	Q9HC78	66	601	330	330	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
ZBTB20	Q9HC78	66	601	330	330	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
ZBTB20	Q9HC78	66	601	371	371	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZBTB20	Q9HC78	66	601	1	73	Alternative sequence	ID=VSP_032503;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:11230166,PMID:15489334,PMID:17974005
ZBTB20	Q9HC78	66	601	590	590	Natural variant	ID=VAR_072583;Note=In PRIMS%3B does not affect subcellular location%3B strongly reduced DNA binding%3B reduced ability to repress transcription%3B dominant-negative effect of the mutant on the wild-type allele. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25017102;Dbxref=dbSNP:rs483353064,PMID:25017102
ZBTB20	Q9HC78	66	601	596	596	Natural variant	ID=VAR_072584;Note=In PRIMS%3B strongly reduced DNA binding%3B strongly reduced ability to repress transcription%3B dominant-negative effect of the mutant on the wild-type allele. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25017102;Dbxref=dbSNP:rs483353066,PMID:25017102
ZBTB20	Q9HC78	66	601	224	224	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB20	Q9HC78	66	601	266	266	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB20	Q9HC78	66	601	332	332	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB20	Q9HC78	66	601	337	337	Sequence conflict	Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB20	Q9HC78	66	601	465	465	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB20	Q9HC78	66	601	517	517	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB20	Q9HC78	66	601	543	543	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZBTB40	Q9NUA8	889	944	1	1239	Chain	ID=PRO_0000047745;Note=Zinc finger and BTB domain-containing protein 40
ZBTB40	Q9NUA8	1070	1099	1	1239	Chain	ID=PRO_0000047745;Note=Zinc finger and BTB domain-containing protein 40
ZBTB40	Q9NUA8	889	944	1	1239	Chain	ID=PRO_0000047745;Note=Zinc finger and BTB domain-containing protein 40
ZBTB40	Q9NUA8	1070	1099	1	1239	Chain	ID=PRO_0000047745;Note=Zinc finger and BTB domain-containing protein 40
ZBTB40	Q9NUA8	889	944	893	915	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB40	Q9NUA8	889	944	893	915	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB40	Q9NUA8	889	944	921	944	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB40	Q9NUA8	889	944	921	944	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB40	Q9NUA8	1070	1099	1075	1098	Zinc finger	Note=C2H2-type 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB40	Q9NUA8	1070	1099	1075	1098	Zinc finger	Note=C2H2-type 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB40	Q9NUA8	889	944	282	1239	Alternative sequence	ID=VSP_007759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZBTB40	Q9NUA8	1070	1099	282	1239	Alternative sequence	ID=VSP_007759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZBTB40	Q9NUA8	889	944	282	1239	Alternative sequence	ID=VSP_007759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZBTB40	Q9NUA8	1070	1099	282	1239	Alternative sequence	ID=VSP_007759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFP82	Q8N141	45	76	1	532	Chain	ID=PRO_0000233164;Note=Zinc finger protein 82 homolog
ZFP82	Q8N141	45	76	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZFY	P08048	127	318	1	801	Chain	ID=PRO_0000047261;Note=Zinc finger Y-chromosomal protein
ZFY	P08048	416	467	1	801	Chain	ID=PRO_0000047261;Note=Zinc finger Y-chromosomal protein
ZFY	P08048	85	276	1	801	Chain	ID=PRO_0000047261;Note=Zinc finger Y-chromosomal protein
ZFY	P08048	374	425	1	801	Chain	ID=PRO_0000047261;Note=Zinc finger Y-chromosomal protein
ZFY	P08048	416	467	421	443	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFY	P08048	374	425	421	443	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFY	P08048	416	467	452	474	Zinc finger	Note=C2H2-type 2%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZFY	P08048	127	318	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17012
ZFY	P08048	85	276	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17012
ZFY	P08048	127	318	22	212	Alternative sequence	ID=VSP_042775;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFY	P08048	85	276	22	212	Alternative sequence	ID=VSP_042775;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFY	P08048	127	318	310	310	Alternative sequence	ID=VSP_042825;Note=In isoform 3. N->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFY	P08048	127	318	311	361	Alternative sequence	ID=VSP_042826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFY	P08048	374	425	398	407	Sequence conflict	Note=RRPDSRQYQT->ALILLSFPFL;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZMYM3	Q14202	1182	1267	1	1370	Chain	ID=PRO_0000191378;Note=Zinc finger MYM-type protein 3
ZMYM3	Q14202	1182	1267	496	1370	Alternative sequence	ID=VSP_043263;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
ZMAT5	Q9UDW3	63	90	1	170	Chain	ID=PRO_0000254114;Note=Zinc finger matrin-type protein 5
ZMAT5	Q9UDW3	42	63	1	170	Chain	ID=PRO_0000254114;Note=Zinc finger matrin-type protein 5
ZMAT5	Q9UDW3	63	90	51	79	Zinc finger	Note=C3H1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZMAT5	Q9UDW3	42	63	51	79	Zinc finger	Note=C3H1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
ZNF618	Q5T7W0	112	144	1	954	Chain	ID=PRO_0000286811;Note=Zinc finger protein 618
ZNF618	Q5T7W0	213	225	1	954	Chain	ID=PRO_0000286811;Note=Zinc finger protein 618
ZNF618	Q5T7W0	281	361	1	954	Chain	ID=PRO_0000286811;Note=Zinc finger protein 618
ZNF618	Q5T7W0	112	144	113	144	Alternative sequence	ID=VSP_025179;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZNF618	Q5T7W0	281	361	282	363	Alternative sequence	ID=VSP_025181;Note=In isoform 2. STAPGWEPPDDPDTGSECSHPEVSPSPRFVAAKTQTNQSGKKAPASVVRCATLLHRTPPATQTQTFRTPNSGSPASKATAAE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF618	Q5T7W0	281	361	283	313	Alternative sequence	ID=VSP_025182;Note=In isoform 3. TAPGWEPPDDPDTGSECSHPEVSPSPRFVAA->EYLLPVGMGVGGPGTGWASRWPGLWNLARKW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF618	Q5T7W0	281	361	314	954	Alternative sequence	ID=VSP_025183;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF618	Q5T7W0	281	361	361	361	Alternative sequence	ID=VSP_055968;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF766	Q5HY98	48	91	1	468	Chain	ID=PRO_0000280435;Note=Zinc finger protein 766
ZNF766	Q5HY98	48	91	9	80	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF766	Q5HY98	48	91	75	75	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
YIF1A	O95070	162	213	2	293	Chain	ID=PRO_0000233275;Note=Protein YIF1A
YIF1A	O95070	81	116	2	293	Chain	ID=PRO_0000233275;Note=Protein YIF1A
YIF1A	O95070	81	116	2	138	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1A	O95070	162	213	160	174	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIF1A	O95070	162	213	175	195	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1A	O95070	162	213	196	203	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
YIF1A	O95070	162	213	204	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1B	Q5BJH7	180	231	1	314	Chain	ID=PRO_0000307258;Note=Protein YIF1B
YIF1B	Q5BJH7	99	134	1	314	Chain	ID=PRO_0000307258;Note=Protein YIF1B
YIF1B	Q5BJH7	99	134	1	156	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1B	Q5BJH7	180	231	178	192	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1B	Q5BJH7	180	231	193	213	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1B	Q5BJH7	180	231	214	219	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
YIF1B	Q5BJH7	180	231	220	240	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
YTHDF2	Q9Y5A9	44	572	2	579	Chain	ID=PRO_0000223075;Note=YTH domain-containing family protein 2
YTHDF2	Q9Y5A9	44	572	2	579	Chain	ID=PRO_0000223075;Note=YTH domain-containing family protein 2
YTHDF2	Q9Y5A9	44	572	410	544	Domain	Note=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
YTHDF2	Q9Y5A9	44	572	410	544	Domain	Note=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
YTHDF2	Q9Y5A9	44	572	2	384	Region	Note=Localization to mRNA processing bodies (P-bodies);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	2	384	Region	Note=Localization to mRNA processing bodies (P-bodies);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	385	579	Region	Note=Interaction with m6A-containing mRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	385	579	Region	Note=Interaction with m6A-containing mRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	416	418	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	416	418	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	432	433	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	432	433	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	422	422	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	422	422	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	462	462	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	462	462	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	486	486	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	486	486	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	491	491	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	491	491	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YTHDF2	Q9Y5A9	44	572	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YTHDF2	Q9Y5A9	44	572	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YTHDF2	Q9Y5A9	44	572	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YTHDF2	Q9Y5A9	44	572	394	394	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
YTHDF2	Q9Y5A9	44	572	394	394	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
YTHDF2	Q9Y5A9	44	572	1	50	Alternative sequence	ID=VSP_009297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
YTHDF2	Q9Y5A9	44	572	1	50	Alternative sequence	ID=VSP_009297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
YTHDF2	Q9Y5A9	44	572	217	217	Natural variant	ID=VAR_053744;Note=T->S;Dbxref=dbSNP:rs16838382
YTHDF2	Q9Y5A9	44	572	217	217	Natural variant	ID=VAR_053744;Note=T->S;Dbxref=dbSNP:rs16838382
YTHDF2	Q9Y5A9	44	572	454	454	Natural variant	ID=VAR_053745;Note=P->S;Dbxref=dbSNP:rs35288745
YTHDF2	Q9Y5A9	44	572	454	454	Natural variant	ID=VAR_053745;Note=P->S;Dbxref=dbSNP:rs35288745
YTHDF2	Q9Y5A9	44	572	411	411	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	411	411	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	416	416	Mutagenesis	Note=Decreased binding to RNAs. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	416	416	Mutagenesis	Note=Decreased binding to RNAs. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	432	432	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	432	432	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	441	441	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	441	441	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	486	486	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	486	486	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	491	491	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	491	491	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	527	527	Mutagenesis	Note=Decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	527	527	Mutagenesis	Note=Decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	411	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	411	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	420	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	420	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	430	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WQN
YTHDF2	Q9Y5A9	44	572	430	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WQN
YTHDF2	Q9Y5A9	44	572	436	449	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	436	449	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	455	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	455	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	464	473	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	464	473	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDO
YTHDF2	Q9Y5A9	44	572	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDO
YTHDF2	Q9Y5A9	44	572	486	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	486	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	494	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	494	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	507	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	507	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	510	512	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	510	512	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	516	520	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	516	520	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	523	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	523	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	534	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	534	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
ZC3H7A	Q8IWR0	182	195	1	971	Chain	ID=PRO_0000106321;Note=Zinc finger CCCH domain-containing protein 7A
ZC3H7A	Q8IWR0	102	155	1	971	Chain	ID=PRO_0000106321;Note=Zinc finger CCCH domain-containing protein 7A
ZC3H7A	Q8IWR0	36	102	1	971	Chain	ID=PRO_0000106321;Note=Zinc finger CCCH domain-containing protein 7A
ZC3H7A	Q8IWR0	182	195	1	971	Chain	ID=PRO_0000106321;Note=Zinc finger CCCH domain-containing protein 7A
ZC3H7A	Q8IWR0	102	155	1	971	Chain	ID=PRO_0000106321;Note=Zinc finger CCCH domain-containing protein 7A
ZC3H7A	Q8IWR0	36	102	1	971	Chain	ID=PRO_0000106321;Note=Zinc finger CCCH domain-containing protein 7A
ZC3H7A	Q8IWR0	36	102	43	76	Repeat	Note=TPR 1
ZC3H7A	Q8IWR0	36	102	43	76	Repeat	Note=TPR 1
ZC3H7A	Q8IWR0	102	155	89	122	Repeat	Note=TPR 2
ZC3H7A	Q8IWR0	36	102	89	122	Repeat	Note=TPR 2
ZC3H7A	Q8IWR0	102	155	89	122	Repeat	Note=TPR 2
ZC3H7A	Q8IWR0	36	102	89	122	Repeat	Note=TPR 2
ZC3H7A	Q8IWR0	102	155	124	156	Repeat	Note=TPR 3
ZC3H7A	Q8IWR0	102	155	124	156	Repeat	Note=TPR 3
ZC3H7A	Q8IWR0	182	195	1	804	Alternative sequence	ID=VSP_014383;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
ZC3H7A	Q8IWR0	102	155	1	804	Alternative sequence	ID=VSP_014383;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
ZC3H7A	Q8IWR0	36	102	1	804	Alternative sequence	ID=VSP_014383;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
ZC3H7A	Q8IWR0	182	195	1	804	Alternative sequence	ID=VSP_014383;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
ZC3H7A	Q8IWR0	102	155	1	804	Alternative sequence	ID=VSP_014383;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
ZC3H7A	Q8IWR0	36	102	1	804	Alternative sequence	ID=VSP_014383;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11042152,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11042152,PMID:14702039,PMID:15489334
ZC3H7A	Q8IWR0	36	102	57	57	Natural variant	ID=VAR_052633;Note=H->R;Dbxref=dbSNP:rs16958654
ZC3H7A	Q8IWR0	36	102	57	57	Natural variant	ID=VAR_052633;Note=H->R;Dbxref=dbSNP:rs16958654
ZNF512B	Q96KM6	776	809	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	721	755	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	599	656	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	566	599	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	535	566	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	420	444	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	88	131	1	892	Chain	ID=PRO_0000047779;Note=Zinc finger protein 512B
ZNF512B	Q96KM6	88	131	105	129	Zinc finger	Note=C2H2-type 1%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	535	566	540	563	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	599	656	594	618	Zinc finger	Note=C2H2-type 4%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	566	599	594	618	Zinc finger	Note=C2H2-type 4%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	599	656	630	653	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	721	755	750	774	Zinc finger	Note=C2H2-type 6%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	776	809	784	807	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512B	Q96KM6	535	566	524	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GQJ
ZNF512B	Q96KM6	535	566	543	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GQJ
ZNF512B	Q96KM6	535	566	552	562	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GQJ
ZACN	Q401N2	293	349	26	412	Chain	ID=PRO_0000317165;Note=Zinc-activated ligand-gated ion channel
ZACN	Q401N2	293	349	287	298	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZACN	Q401N2	293	349	299	319	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZACN	Q401N2	293	349	320	368	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ZACN	Q401N2	293	349	224	318	Compositional bias	Note=Leu-rich
ZACN	Q401N2	293	349	127	412	Alternative sequence	ID=VSP_030910;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZACN	Q401N2	293	349	267	412	Alternative sequence	ID=VSP_030912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZCCHC10	Q8TBK6	90	103	1	192	Chain	ID=PRO_0000150967;Note=Zinc finger CCHC domain-containing protein 10
ZCCHC10	Q8TBK6	36	89	1	192	Chain	ID=PRO_0000150967;Note=Zinc finger CCHC domain-containing protein 10
ZCCHC10	Q8TBK6	14	35	1	192	Chain	ID=PRO_0000150967;Note=Zinc finger CCHC domain-containing protein 10
ZCCHC10	Q8TBK6	36	89	43	60	Zinc finger	Note=CCHC-type
ZCCHC10	Q8TBK6	36	89	15	36	Alternative sequence	ID=VSP_013718;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZCCHC10	Q8TBK6	14	35	15	36	Alternative sequence	ID=VSP_013718;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ZC3H13	Q5T200	1490	1557	1	1668	Chain	ID=PRO_0000050778;Note=Zinc finger CCCH domain-containing protein 13
WBP2NL	Q6ICG8	135	171	1	309	Chain	ID=PRO_0000289127;Note=Postacrosomal sheath WW domain-binding protein
WBP2NL	Q6ICG8	135	171	170	170	Natural variant	ID=VAR_032580;Note=C->F;Dbxref=dbSNP:rs17002802
WBP2NL	Q6ICG8	135	171	136	136	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR49	Q8IV35	450	516	1	697	Chain	ID=PRO_0000252428;Note=WD repeat-containing protein 49
WDR49	Q8IV35	84	162	1	697	Chain	ID=PRO_0000252428;Note=WD repeat-containing protein 49
WDR49	Q8IV35	84	162	60	99	Repeat	Note=WD 2
WDR49	Q8IV35	84	162	146	187	Repeat	Note=WD 3
WDR49	Q8IV35	450	516	417	457	Repeat	Note=WD 7
WDR49	Q8IV35	450	516	473	514	Repeat	Note=WD 8
WDR49	Q8IV35	84	162	1	175	Alternative sequence	ID=VSP_020962;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR4	P57081	209	242	2	412	Chain	ID=PRO_0000051348;Note=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
WDR4	P57081	52	98	2	412	Chain	ID=PRO_0000051348;Note=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
WDR4	P57081	209	242	2	412	Chain	ID=PRO_0000051348;Note=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
WDR4	P57081	52	98	2	412	Chain	ID=PRO_0000051348;Note=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
WDR4	P57081	30	51	2	412	Chain	ID=PRO_0000051348;Note=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
WDR4	P57081	30	51	3	40	Repeat	Note=WD 1
WDR4	P57081	52	98	50	90	Repeat	Note=WD 2
WDR4	P57081	52	98	50	90	Repeat	Note=WD 2
WDR4	P57081	30	51	50	90	Repeat	Note=WD 2
WDR4	P57081	52	98	94	131	Repeat	Note=WD 3
WDR4	P57081	52	98	94	131	Repeat	Note=WD 3
WDR4	P57081	209	242	180	218	Repeat	Note=WD 5
WDR4	P57081	209	242	180	218	Repeat	Note=WD 5
WDR4	P57081	209	242	230	273	Repeat	Note=WD 6
WDR4	P57081	209	242	230	273	Repeat	Note=WD 6
WDR4	P57081	52	98	1	146	Alternative sequence	ID=VSP_036935;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
WDR4	P57081	52	98	1	146	Alternative sequence	ID=VSP_036935;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
WDR4	P57081	30	51	1	146	Alternative sequence	ID=VSP_036935;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
WDR4	P57081	52	98	71	71	Natural variant	ID=VAR_020120;Note=K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2248490,PMID:14702039
WDR4	P57081	52	98	71	71	Natural variant	ID=VAR_020120;Note=K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2248490,PMID:14702039
WDR4	P57081	209	242	236	236	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR4	P57081	209	242	236	236	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR37	Q9Y2I8	201	216	1	494	Chain	ID=PRO_0000051387;Note=WD repeat-containing protein 37
WDR37	Q9Y2I8	201	216	1	494	Chain	ID=PRO_0000051387;Note=WD repeat-containing protein 37
WDR37	Q9Y2I8	201	216	197	236	Repeat	Note=WD 2
WDR37	Q9Y2I8	201	216	197	236	Repeat	Note=WD 2
WDR76	Q9H967	154	184	1	626	Chain	ID=PRO_0000242691;Note=WD repeat-containing protein 76
WDR76	Q9H967	244	278	1	626	Chain	ID=PRO_0000242691;Note=WD repeat-containing protein 76
WDR76	Q9H967	344	397	1	626	Chain	ID=PRO_0000242691;Note=WD repeat-containing protein 76
WDR76	Q9H967	470	520	1	626	Chain	ID=PRO_0000242691;Note=WD repeat-containing protein 76
WDR76	Q9H967	344	397	311	352	Repeat	Note=WD 1
WDR76	Q9H967	344	397	358	400	Repeat	Note=WD 2
WDR76	Q9H967	470	520	446	485	Repeat	Note=WD 4
WDR76	Q9H967	470	520	493	533	Repeat	Note=WD 5
WDR7	Q9Y4E6	949	982	1	1490	Chain	ID=PRO_0000051353;Note=WD repeat-containing protein 7
WDR7	Q9Y4E6	1063	1101	1	1490	Chain	ID=PRO_0000051353;Note=WD repeat-containing protein 7
WDR7	Q9Y4E6	1101	1175	1	1490	Chain	ID=PRO_0000051353;Note=WD repeat-containing protein 7
WDR7	Q9Y4E6	1277	1327	1	1490	Chain	ID=PRO_0000051353;Note=WD repeat-containing protein 7
WDR7	Q9Y4E6	949	982	950	982	Alternative sequence	ID=VSP_015274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
WIPF2	Q8TF74	65	104	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	104	323	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	323	393	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	65	104	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	104	323	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	323	393	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	65	104	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	104	323	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	323	393	1	440	Chain	ID=PRO_0000065975;Note=WAS/WASL-interacting protein family member 2
WIPF2	Q8TF74	104	323	177	182	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	177	182	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	177	182	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	250	254	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	250	254	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	250	254	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	296	299	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	296	299	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	296	299	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	311	314	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	311	314	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	104	323	311	314	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	325	330	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	325	330	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	325	330	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	340	345	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	340	345	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	340	345	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	359	363	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	359	363	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	359	363	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	370	377	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	370	377	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	323	393	370	377	Compositional bias	Note=Poly-Pro
WIPF2	Q8TF74	65	104	1	150	Alternative sequence	ID=VSP_012967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WIPF2	Q8TF74	104	323	1	150	Alternative sequence	ID=VSP_012967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WIPF2	Q8TF74	65	104	1	150	Alternative sequence	ID=VSP_012967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WIPF2	Q8TF74	104	323	1	150	Alternative sequence	ID=VSP_012967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WIPF2	Q8TF74	65	104	1	150	Alternative sequence	ID=VSP_012967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WIPF2	Q8TF74	104	323	1	150	Alternative sequence	ID=VSP_012967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WIPF2	Q8TF74	65	104	82	82	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
WIPF2	Q8TF74	65	104	82	82	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
WIPF2	Q8TF74	65	104	82	82	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
WSCD2	Q2TBF2	381	448	1	565	Chain	ID=PRO_0000305065;Note=WSC domain-containing protein 2
WSCD2	Q2TBF2	381	448	1	565	Chain	ID=PRO_0000305065;Note=WSC domain-containing protein 2
WSCD2	Q2TBF2	381	448	448	448	Alternative sequence	ID=VSP_028211;Note=In isoform 2. K->KGAVPGSLQILFRSICTASVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WSCD2	Q2TBF2	381	448	448	448	Alternative sequence	ID=VSP_028211;Note=In isoform 2. K->KGAVPGSLQILFRSICTASVG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDSUB1	Q8N9V3	285	332	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	225	285	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	194	225	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	377	424	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	194	225	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	377	424	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	194	225	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	377	424	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	194	225	1	476	Chain	ID=PRO_0000278608;Note=WD repeat%2C SAM and U-box domain-containing protein 1
WDSUB1	Q8N9V3	225	285	178	228	Repeat	Note=WD 5
WDSUB1	Q8N9V3	194	225	178	228	Repeat	Note=WD 5
WDSUB1	Q8N9V3	194	225	178	228	Repeat	Note=WD 5
WDSUB1	Q8N9V3	194	225	178	228	Repeat	Note=WD 5
WDSUB1	Q8N9V3	194	225	178	228	Repeat	Note=WD 5
WDSUB1	Q8N9V3	225	285	237	276	Repeat	Note=WD 6
WDSUB1	Q8N9V3	285	332	279	318	Repeat	Note=WD 7
WDSUB1	Q8N9V3	225	285	279	318	Repeat	Note=WD 7
WDSUB1	Q8N9V3	285	332	332	396	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
WDSUB1	Q8N9V3	377	424	332	396	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
WDSUB1	Q8N9V3	377	424	332	396	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
WDSUB1	Q8N9V3	377	424	332	396	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
WDSUB1	Q8N9V3	377	424	403	476	Domain	Note=U-box
WDSUB1	Q8N9V3	377	424	403	476	Domain	Note=U-box
WDSUB1	Q8N9V3	377	424	403	476	Domain	Note=U-box
WDSUB1	Q8N9V3	285	332	226	317	Alternative sequence	ID=VSP_023337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDSUB1	Q8N9V3	225	285	226	317	Alternative sequence	ID=VSP_023337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDSUB1	Q8N9V3	194	225	215	215	Natural variant	ID=VAR_030791;Note=K->T;Dbxref=dbSNP:rs16843852
WDSUB1	Q8N9V3	194	225	215	215	Natural variant	ID=VAR_030791;Note=K->T;Dbxref=dbSNP:rs16843852
WDSUB1	Q8N9V3	194	225	215	215	Natural variant	ID=VAR_030791;Note=K->T;Dbxref=dbSNP:rs16843852
WDSUB1	Q8N9V3	194	225	215	215	Natural variant	ID=VAR_030791;Note=K->T;Dbxref=dbSNP:rs16843852
WDSUB1	Q8N9V3	194	225	223	223	Natural variant	ID=VAR_030792;Note=H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852677,PMID:15489334
WDSUB1	Q8N9V3	194	225	223	223	Natural variant	ID=VAR_030792;Note=H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852677,PMID:15489334
WDSUB1	Q8N9V3	194	225	223	223	Natural variant	ID=VAR_030792;Note=H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852677,PMID:15489334
WDSUB1	Q8N9V3	194	225	223	223	Natural variant	ID=VAR_030792;Note=H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852677,PMID:15489334
WDSUB1	Q8N9V3	285	332	320	320	Natural variant	ID=VAR_030793;Note=R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs7591849,PMID:14702039
VRK3	Q8IV63	290	321	1	474	Chain	ID=PRO_0000086808;Note=Inactive serine/threonine-protein kinase VRK3
VRK3	Q8IV63	46	96	1	474	Chain	ID=PRO_0000086808;Note=Inactive serine/threonine-protein kinase VRK3
VRK3	Q8IV63	290	321	1	474	Chain	ID=PRO_0000086808;Note=Inactive serine/threonine-protein kinase VRK3
VRK3	Q8IV63	46	96	1	474	Chain	ID=PRO_0000086808;Note=Inactive serine/threonine-protein kinase VRK3
VRK3	Q8IV63	290	321	1	474	Chain	ID=PRO_0000086808;Note=Inactive serine/threonine-protein kinase VRK3
VRK3	Q8IV63	46	96	1	474	Chain	ID=PRO_0000086808;Note=Inactive serine/threonine-protein kinase VRK3
VRK3	Q8IV63	290	321	166	457	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
VRK3	Q8IV63	290	321	166	457	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
VRK3	Q8IV63	290	321	166	457	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
VRK3	Q8IV63	46	96	49	64	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14645249;Dbxref=PMID:14645249
VRK3	Q8IV63	46	96	49	64	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14645249;Dbxref=PMID:14645249
VRK3	Q8IV63	46	96	49	64	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14645249;Dbxref=PMID:14645249
VRK3	Q8IV63	46	96	54	54	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VRK3	Q8IV63	46	96	54	54	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VRK3	Q8IV63	46	96	54	54	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VRK3	Q8IV63	46	96	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
VRK3	Q8IV63	46	96	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
VRK3	Q8IV63	46	96	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
VRK3	Q8IV63	46	96	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
VRK3	Q8IV63	46	96	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
VRK3	Q8IV63	46	96	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
VRK3	Q8IV63	46	96	82	82	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692
VRK3	Q8IV63	46	96	82	82	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692
VRK3	Q8IV63	46	96	82	82	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692
VRK3	Q8IV63	46	96	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
VRK3	Q8IV63	46	96	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
VRK3	Q8IV63	46	96	83	83	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
VRK3	Q8IV63	46	96	90	90	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
VRK3	Q8IV63	46	96	90	90	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
VRK3	Q8IV63	46	96	90	90	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
VRK3	Q8IV63	46	96	47	96	Alternative sequence	ID=VSP_043409;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VRK3	Q8IV63	46	96	47	96	Alternative sequence	ID=VSP_043409;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VRK3	Q8IV63	46	96	47	96	Alternative sequence	ID=VSP_043409;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VRK3	Q8IV63	46	96	59	59	Natural variant	ID=VAR_041295;Note=S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2033262,PMID:17344846
VRK3	Q8IV63	46	96	59	59	Natural variant	ID=VAR_041295;Note=S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2033262,PMID:17344846
VRK3	Q8IV63	46	96	59	59	Natural variant	ID=VAR_041295;Note=S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2033262,PMID:17344846
VRK3	Q8IV63	290	321	304	304	Natural variant	ID=VAR_051684;Note=H->L;Dbxref=dbSNP:rs35261919
VRK3	Q8IV63	290	321	304	304	Natural variant	ID=VAR_051684;Note=H->L;Dbxref=dbSNP:rs35261919
VRK3	Q8IV63	290	321	304	304	Natural variant	ID=VAR_051684;Note=H->L;Dbxref=dbSNP:rs35261919
VRK3	Q8IV63	290	321	280	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	280	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	280	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	311	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	311	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	311	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	318	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	318	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VRK3	Q8IV63	290	321	318	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JII
VSTM2L	Q96N03	97	114	25	204	Chain	ID=PRO_0000015164;Note=V-set and transmembrane domain-containing protein 2-like protein
VSTM2L	Q96N03	97	114	41	158	Domain	Note=Ig-like
VSTM2L	Q96N03	97	114	62	142	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VSTM2L	Q96N03	97	114	41	132	Alternative sequence	ID=VSP_026512;Note=In isoform 3. ALFTETPHDMTARTGEDVEMACSFRGSGSPSYSLEIQWWYVRSHRDWTDKQAWASNQLKASQQEDAGKEATKISVVKVVGSNISHKLRLSRV->GGQGGGQQHLPQAAPVPGEAHGRRHLRVPRHRLQRRQGPAPQGQGLPAGAARGELRPASARSPSRRARPAAPQARQGAEEALGGPGGLQPLD;Ontology_term=ECO:0000305;evidence=ECO:0000305
VSTM2L	Q96N03	97	114	98	114	Alternative sequence	ID=VSP_013380;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
VWDE	Q8N2E2	1519	1551	21	1590	Chain	ID=PRO_0000329441;Note=von Willebrand factor D and EGF domain-containing protein
VWDE	Q8N2E2	1391	1423	21	1590	Chain	ID=PRO_0000329441;Note=von Willebrand factor D and EGF domain-containing protein
VWDE	Q8N2E2	1391	1423	1422	1454	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWDE	Q8N2E2	1519	1551	1518	1550	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWDE	Q8N2E2	1519	1551	1551	1582	Domain	Note=EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWDE	Q8N2E2	1519	1551	1522	1532	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VWDE	Q8N2E2	1519	1551	1526	1538	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VWDE	Q8N2E2	1519	1551	1540	1549	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
WBP2	Q969T9	132	177	1	261	Chain	ID=PRO_0000065950;Note=WW domain-binding protein 2
WBP2	Q969T9	101	132	1	261	Chain	ID=PRO_0000065950;Note=WW domain-binding protein 2
WBP2	Q969T9	132	177	1	261	Chain	ID=PRO_0000065950;Note=WW domain-binding protein 2
WBP2	Q969T9	101	132	1	261	Chain	ID=PRO_0000065950;Note=WW domain-binding protein 2
WBP2	Q969T9	132	177	146	255	Compositional bias	Note=Pro-rich
WBP2	Q969T9	132	177	146	255	Compositional bias	Note=Pro-rich
WBP2	Q969T9	132	177	133	177	Alternative sequence	ID=VSP_059233;Note=In isoform 2. Missing
WBP2	Q969T9	132	177	133	177	Alternative sequence	ID=VSP_059233;Note=In isoform 2. Missing
WBP2	Q969T9	132	177	160	160	Natural variant	ID=VAR_079500;Note=In DFNB107. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26881968;Dbxref=dbSNP:rs202022024,PMID:26881968
WBP2	Q969T9	132	177	160	160	Natural variant	ID=VAR_079500;Note=In DFNB107. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26881968;Dbxref=dbSNP:rs202022024,PMID:26881968
WBP2	Q969T9	132	177	163	163	Natural variant	ID=VAR_079501;Note=In DFNB107%3B unknown pathological significance. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26881968;Dbxref=PMID:26881968
WBP2	Q969T9	132	177	163	163	Natural variant	ID=VAR_079501;Note=In DFNB107%3B unknown pathological significance. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26881968;Dbxref=PMID:26881968
WBP2	Q969T9	132	177	143	143	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	143	143	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	145	145	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	145	145	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	153	153	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	153	153	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	164	164	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	164	164	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	170	170	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	170	170	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	172	172	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WBP2	Q969T9	132	177	172	172	Mutagenesis	Note=No effect on phosphorylation induced by EGF. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21642474;Dbxref=PMID:21642474
WDR19	Q8NEZ3	33	54	1	1342	Chain	ID=PRO_0000233156;Note=WD repeat-containing protein 19
WDR19	Q8NEZ3	493	543	1	1342	Chain	ID=PRO_0000233156;Note=WD repeat-containing protein 19
WDR19	Q8NEZ3	1061	1087	1	1342	Chain	ID=PRO_0000233156;Note=WD repeat-containing protein 19
WDR19	Q8NEZ3	33	54	11	51	Repeat	Note=WD 1
WDR19	Q8NEZ3	33	54	52	92	Repeat	Note=WD 2
WDR19	Q8NEZ3	493	543	475	1342	Alternative sequence	ID=VSP_018074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
WDR19	Q8NEZ3	1061	1087	475	1342	Alternative sequence	ID=VSP_018074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
WDR19	Q8NEZ3	493	543	493	493	Natural variant	ID=VAR_073677;Note=In SLSN8. D->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23559409,ECO:0000269|PubMed:23683095;Dbxref=dbSNP:rs587777349,PMID:23559409,PMID:23683095
WDR19	Q8NEZ3	1061	1087	1084	1084	Natural variant	ID=VAR_053424;Note=G->S;Dbxref=dbSNP:rs16995209
WDR54	Q9H977	117	135	1	334	Chain	ID=PRO_0000051415;Note=WD repeat-containing protein 54
WDR54	Q9H977	117	135	105	147	Repeat	Note=WD 3
WDR38	Q5JTN6	135	162	1	314	Chain	ID=PRO_0000294440;Note=WD repeat-containing protein 38
WDR38	Q5JTN6	135	162	103	142	Repeat	Note=WD 3
WDR38	Q5JTN6	135	162	145	184	Repeat	Note=WD 4
WDR60	Q8WVS4	882	926	1	1066	Chain	ID=PRO_0000242142;Note=WD repeat-containing protein 60
WDR60	Q8WVS4	882	926	849	898	Repeat	Note=WD 5
WDR60	Q8WVS4	882	926	899	944	Repeat	Note=WD 6
WDR60	Q8WVS4	882	926	642	1066	Natural variant	ID=VAR_079178;Note=In SRTD8. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25492405;Dbxref=PMID:25492405
WDTC1	Q8N5D0	16	44	1	677	Chain	ID=PRO_0000051434;Note=WD and tetratricopeptide repeats protein 1
WDTC1	Q8N5D0	160	220	1	677	Chain	ID=PRO_0000051434;Note=WD and tetratricopeptide repeats protein 1
WDTC1	Q8N5D0	160	220	132	172	Repeat	Note=WD 3
WDTC1	Q8N5D0	160	220	182	222	Repeat	Note=WD 4
WDFY1	Q8IWB7	277	311	1	410	Chain	ID=PRO_0000051335;Note=WD repeat and FYVE domain-containing protein 1
WDFY1	Q8IWB7	277	311	240	279	Repeat	Note=WD 6
WDFY1	Q8IWB7	277	311	281	352	Zinc finger	Note=FYVE-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091
WEE1	P30291	380	429	1	646	Chain	ID=PRO_0000086810;Note=Wee1-like protein kinase
WEE1	P30291	380	429	299	569	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
WEE1	P30291	380	429	426	426	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
WEE1	P30291	380	429	384	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B
WEE1	P30291	380	429	400	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B
WEE1	P30291	380	429	429	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B
ZNF254	O75437	52	84	1	659	Chain	ID=PRO_0000047487;Note=Zinc finger protein 254
ZNF254	O75437	52	84	13	84	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF550	Q7Z398	51	83	1	422	Chain	ID=PRO_0000234585;Note=Zinc finger protein 550
ZNF550	Q7Z398	51	83	12	83	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF550	Q7Z398	51	83	53	84	Alternative sequence	ID=VSP_018380;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF264	O43296	53	85	1	627	Chain	ID=PRO_0000047492;Note=Zinc finger protein 264
ZNF264	O43296	53	85	1	627	Chain	ID=PRO_0000047492;Note=Zinc finger protein 264
ZNF264	O43296	53	85	14	85	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF264	O43296	53	85	14	85	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF264	O43296	53	85	80	80	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
ZNF264	O43296	53	85	80	80	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
ZNF596	Q8TC21	46	74	1	504	Chain	ID=PRO_0000245849;Note=Zinc finger protein 596
ZNF596	Q8TC21	46	74	1	504	Chain	ID=PRO_0000245849;Note=Zinc finger protein 596
ZNF596	Q8TC21	46	74	7	78	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF596	Q8TC21	46	74	7	78	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF596	Q8TC21	46	74	1	101	Alternative sequence	ID=VSP_019801;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF596	Q8TC21	46	74	1	101	Alternative sequence	ID=VSP_019801;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF596	Q8TC21	46	74	48	117	Alternative sequence	ID=VSP_019802;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF596	Q8TC21	46	74	48	117	Alternative sequence	ID=VSP_019802;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF337	Q9Y3M9	51	83	1	751	Chain	ID=PRO_0000047540;Note=Zinc finger protein 337
ZNF337	Q9Y3M9	51	83	1	751	Chain	ID=PRO_0000047540;Note=Zinc finger protein 337
ZNF337	Q9Y3M9	51	83	12	83	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF337	Q9Y3M9	51	83	12	83	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF337	Q9Y3M9	51	83	52	83	Alternative sequence	ID=VSP_055949;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF337	Q9Y3M9	51	83	52	83	Alternative sequence	ID=VSP_055949;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF346	Q9UL40	93	124	1	294	Chain	ID=PRO_0000191809;Note=Zinc finger protein 346
ZNF346	Q9UL40	172	234	1	294	Chain	ID=PRO_0000191809;Note=Zinc finger protein 346
ZNF346	Q9UL40	93	124	70	104	Zinc finger	Note=Matrin-type 1
ZNF346	Q9UL40	172	234	182	216	Zinc finger	Note=Matrin-type 3
ZNF346	Q9UL40	93	124	97	97	Metal binding	Note=Zinc 1%3B via pros nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF346	Q9UL40	93	124	114	114	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF346	Q9UL40	93	124	94	125	Alternative sequence	ID=VSP_055098;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF346	Q9UL40	172	234	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MKD
ZNF346	Q9UL40	172	234	185	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MKD
ZNF346	Q9UL40	172	234	188	191	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MKD
ZNF346	Q9UL40	172	234	192	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MKD
ZNF346	Q9UL40	172	234	197	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MKD
ZNF346	Q9UL40	172	234	207	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MKD
ZNF610	Q8N9Z0	63	106	1	462	Chain	ID=PRO_0000234595;Note=Zinc finger protein 610
ZNF610	Q8N9Z0	63	106	1	462	Chain	ID=PRO_0000234595;Note=Zinc finger protein 610
ZNF610	Q8N9Z0	63	106	1	462	Chain	ID=PRO_0000234595;Note=Zinc finger protein 610
ZNF610	Q8N9Z0	63	106	24	95	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF610	Q8N9Z0	63	106	24	95	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF610	Q8N9Z0	63	106	24	95	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF610	Q8N9Z0	63	106	65	107	Alternative sequence	ID=VSP_018387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF610	Q8N9Z0	63	106	65	107	Alternative sequence	ID=VSP_018387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF610	Q8N9Z0	63	106	65	107	Alternative sequence	ID=VSP_018387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF610	Q8N9Z0	63	106	104	104	Natural variant	ID=VAR_052873;Note=V->M;Dbxref=dbSNP:rs3815905
ZNF610	Q8N9Z0	63	106	104	104	Natural variant	ID=VAR_052873;Note=V->M;Dbxref=dbSNP:rs3815905
ZNF610	Q8N9Z0	63	106	104	104	Natural variant	ID=VAR_052873;Note=V->M;Dbxref=dbSNP:rs3815905
ZNF534	Q76KX8	60	103	1	674	Chain	ID=PRO_0000394145;Note=Zinc finger protein 534
ZNF534	Q76KX8	60	103	8	92	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF534	Q76KX8	60	103	48	60	Alternative sequence	ID=VSP_039177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ZNF680	Q8NEM1	52	84	1	530	Chain	ID=PRO_0000234000;Note=Zinc finger protein 680
ZNF680	Q8NEM1	52	84	13	84	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF92	Q03936	43	75	1	586	Chain	ID=PRO_0000047401;Note=Zinc finger protein 92
ZNF92	Q03936	43	75	4	75	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF92	Q03936	43	75	1	69	Alternative sequence	ID=VSP_016964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZNF92	Q03936	43	75	44	75	Alternative sequence	ID=VSP_016965;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2023909;Dbxref=PMID:2023909
SLC30A5	Q8TAD4	666	709	1	765	Chain	ID=PRO_0000314293;Note=Zinc transporter 5
SLC30A5	Q8TAD4	666	709	639	765	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC30A5	Q8TAD4	666	709	119	765	Alternative sequence	ID=VSP_043674;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC30A5	Q8TAD4	666	709	667	694	Alternative sequence	ID=VSP_030255;Note=In isoform 2. IQKIEGLISYRDPHFWRHSASIVAGTIH->VLYVISSLLSSLKITFLKSLLEVKQTTK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11937503;Dbxref=PMID:11937503
SLC30A5	Q8TAD4	666	709	695	765	Alternative sequence	ID=VSP_030256;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11937503;Dbxref=PMID:11937503
ZNFX1	Q9P2E3	1072	1104	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	1035	1072	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	717	767	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	623	667	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	20	623	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	1072	1104	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	1035	1072	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	717	767	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	623	667	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	20	623	1	1918	Chain	ID=PRO_0000050795;Note=NFX1-type zinc finger-containing protein 1
ZNFX1	Q9P2E3	20	623	286	313	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNFX1	Q9P2E3	20	623	286	313	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNFX1	Q9P2E3	1072	1104	904	1918	Alternative sequence	ID=VSP_002435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNFX1	Q9P2E3	1035	1072	904	1918	Alternative sequence	ID=VSP_002435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNFX1	Q9P2E3	1072	1104	904	1918	Alternative sequence	ID=VSP_002435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNFX1	Q9P2E3	1035	1072	904	1918	Alternative sequence	ID=VSP_002435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNFX1	Q9P2E3	717	767	738	738	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNFX1	Q9P2E3	717	767	738	738	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNFX1	Q9P2E3	717	767	755	755	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNFX1	Q9P2E3	717	767	755	755	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF425	Q6IV72	48	101	1	752	Chain	ID=PRO_0000234577;Note=Zinc finger protein 425
ZNF425	Q6IV72	48	101	9	80	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZMYND10	O75800	291	333	1	440	Chain	ID=PRO_0000218314;Note=Zinc finger MYND domain-containing protein 10
ZMYND10	O75800	124	170	1	440	Chain	ID=PRO_0000218314;Note=Zinc finger MYND domain-containing protein 10
ZMYND10	O75800	291	333	323	440	Natural variant	ID=VAR_080482;Note=In CILD22%3B loss of interaction with LRRC6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23891469;Dbxref=PMID:23891469
ZMYND10	O75800	124	170	134	134	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF512	Q96ME7	124	152	1	567	Chain	ID=PRO_0000047630;Note=Zinc finger protein 512
ZNF512	Q96ME7	194	223	1	567	Chain	ID=PRO_0000047630;Note=Zinc finger protein 512
ZNF512	Q96ME7	312	377	1	567	Chain	ID=PRO_0000047630;Note=Zinc finger protein 512
ZNF512	Q96ME7	194	223	197	220	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF512	Q96ME7	312	377	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
ZNF512	Q96ME7	124	152	126	153	Alternative sequence	ID=VSP_046935;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNF512	Q96ME7	194	223	200	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTD
ZNF512	Q96ME7	194	223	209	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CTD
ZNF740	Q8NDX6	3	53	1	193	Chain	ID=PRO_0000251401;Note=Zinc finger protein 740
ZNF740	Q8NDX6	53	83	1	193	Chain	ID=PRO_0000251401;Note=Zinc finger protein 740
ZNF740	Q8NDX6	3	53	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
ZNF740	Q8NDX6	3	53	34	34	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ZNF606	Q8WXB4	10	29	1	792	Chain	ID=PRO_0000047688;Note=Zinc finger protein 606
ZNF821	O75541	13	55	1	412	Chain	ID=PRO_0000317289;Note=Zinc finger protein 821
ZNF821	O75541	13	55	1	412	Chain	ID=PRO_0000317289;Note=Zinc finger protein 821
ZNF821	O75541	13	55	16	57	Alternative sequence	ID=VSP_030933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
ZNF821	O75541	13	55	16	57	Alternative sequence	ID=VSP_030933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
ZNF423	Q2M1K9	25	92	1	1284	Chain	ID=PRO_0000308595;Note=Zinc finger protein 423
ZNF423	Q2M1K9	25	92	1	1284	Chain	ID=PRO_0000308595;Note=Zinc finger protein 423
ZNF423	Q2M1K9	25	92	67	93	Zinc finger	Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF423	Q2M1K9	25	92	67	93	Zinc finger	Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF423	Q2M1K9	25	92	47	47	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
ZNF423	Q2M1K9	25	92	47	47	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
ZNF423	Q2M1K9	25	92	50	50	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
ZNF423	Q2M1K9	25	92	50	50	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
ZNF423	Q2M1K9	25	92	1	60	Alternative sequence	ID=VSP_057595;Note=In isoform 2. Missing
ZNF423	Q2M1K9	25	92	1	60	Alternative sequence	ID=VSP_057595;Note=In isoform 2. Missing
ZNF536	O15090	723	774	1	1300	Chain	ID=PRO_0000271041;Note=Zinc finger protein 536
ZNF536	O15090	723	774	751	773	Zinc finger	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF540	Q8NDQ6	45	77	1	660	Chain	ID=PRO_0000047641;Note=Zinc finger protein 540
ZNF540	Q8NDQ6	45	77	1	660	Chain	ID=PRO_0000047641;Note=Zinc finger protein 540
ZNF540	Q8NDQ6	45	77	1	660	Chain	ID=PRO_0000047641;Note=Zinc finger protein 540
ZNF540	Q8NDQ6	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF540	Q8NDQ6	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF540	Q8NDQ6	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF540	Q8NDQ6	45	77	1	77	Alternative sequence	ID=VSP_016036;Note=In isoform 4. MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP->MLPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQENNFCLLLCFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	1	77	Alternative sequence	ID=VSP_016036;Note=In isoform 4. MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP->MLPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQENNFCLLLCFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	1	77	Alternative sequence	ID=VSP_016036;Note=In isoform 4. MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP->MLPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQENNFCLLLCFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	46	77	Alternative sequence	ID=VSP_016037;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF540	Q8NDQ6	45	77	46	77	Alternative sequence	ID=VSP_016037;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF540	Q8NDQ6	45	77	46	77	Alternative sequence	ID=VSP_016037;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF540	Q8NDQ6	45	77	53	53	Natural variant	ID=VAR_033575;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1975937,PMID:14702039
ZNF540	Q8NDQ6	45	77	53	53	Natural variant	ID=VAR_033575;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1975937,PMID:14702039
ZNF540	Q8NDQ6	45	77	53	53	Natural variant	ID=VAR_033575;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1975937,PMID:14702039
ZNF76	P36508	51	77	1	570	Chain	ID=PRO_0000047386;Note=Zinc finger protein 76
ZNF76	P36508	144	183	1	570	Chain	ID=PRO_0000047386;Note=Zinc finger protein 76
ZNF76	P36508	250	310	1	570	Chain	ID=PRO_0000047386;Note=Zinc finger protein 76
ZNF76	P36508	443	498	1	570	Chain	ID=PRO_0000047386;Note=Zinc finger protein 76
ZNF76	P36508	51	77	62	73	Repeat	Note=2
ZNF76	P36508	144	183	165	189	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF76	P36508	250	310	255	279	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF76	P36508	250	310	285	309	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZNF76	P36508	51	77	34	99	Region	Note=3 X 12 AA approximate repeats
ZNF76	P36508	443	498	444	498	Alternative sequence	ID=VSP_006894;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1427894;Dbxref=PMID:1427894
ZNF76	P36508	250	310	272	272	Natural variant	ID=VAR_033547;Note=R->C;Dbxref=dbSNP:rs33959228
TRPM2	O94759	1291	1324	1	1503	Chain	ID=PRO_0000215326;Note=Transient receptor potential cation channel subfamily M member 2
TRPM2	O94759	1291	1324	1	1503	Chain	ID=PRO_0000215326;Note=Transient receptor potential cation channel subfamily M member 2
TRPM2	O94759	1291	1324	1047	1503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM2	O94759	1291	1324	1047	1503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM2	O94759	1291	1324	847	1503	Alternative sequence	ID=VSP_013018;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12594222;Dbxref=PMID:12594222
TRPM2	O94759	1291	1324	847	1503	Alternative sequence	ID=VSP_013018;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12594222;Dbxref=PMID:12594222
TRPM2	O94759	1291	1324	1291	1325	Alternative sequence	ID=VSP_006575;Note=In isoform 2. DTLEPLSTIQYNVVDGLRDRRSFHGPYTVQAGLPL->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11960981;Dbxref=PMID:11960981
TRPM2	O94759	1291	1324	1291	1325	Alternative sequence	ID=VSP_006575;Note=In isoform 2. DTLEPLSTIQYNVVDGLRDRRSFHGPYTVQAGLPL->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11960981;Dbxref=PMID:11960981
TRUB2	O95900	80	105	11	331	Chain	ID=PRO_0000252090;Note=Mitochondrial mRNA pseudouridine synthase TRUB2
TRUB2	O95900	80	105	98	98	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRUB2	O95900	80	105	93	93	Natural variant	ID=VAR_027749;Note=V->L;Dbxref=dbSNP:rs2072394
TSACC	Q96A04	11	54	1	125	Chain	ID=PRO_0000271073;Note=TSSK6-activating co-chaperone protein
TSACC	Q96A04	11	54	1	125	Chain	ID=PRO_0000271073;Note=TSSK6-activating co-chaperone protein
TSACC	Q96A04	11	54	1	125	Chain	ID=PRO_0000271073;Note=TSSK6-activating co-chaperone protein
TSACC	Q96A04	11	54	1	125	Chain	ID=PRO_0000271073;Note=TSSK6-activating co-chaperone protein
TSACC	Q96A04	11	54	1	125	Chain	ID=PRO_0000271073;Note=TSSK6-activating co-chaperone protein
TSACC	Q96A04	11	54	54	54	Natural variant	ID=VAR_061567;Note=S->L;Dbxref=dbSNP:rs41265043
TSACC	Q96A04	11	54	54	54	Natural variant	ID=VAR_061567;Note=S->L;Dbxref=dbSNP:rs41265043
TSACC	Q96A04	11	54	54	54	Natural variant	ID=VAR_061567;Note=S->L;Dbxref=dbSNP:rs41265043
TSACC	Q96A04	11	54	54	54	Natural variant	ID=VAR_061567;Note=S->L;Dbxref=dbSNP:rs41265043
TSACC	Q96A04	11	54	54	54	Natural variant	ID=VAR_061567;Note=S->L;Dbxref=dbSNP:rs41265043
TSPAN11	A1L157	28	92	1	253	Chain	ID=PRO_0000311905;Note=Tetraspanin-11
TSPAN11	A1L157	92	117	1	253	Chain	ID=PRO_0000311905;Note=Tetraspanin-11
TSPAN11	A1L157	152	205	1	253	Chain	ID=PRO_0000311905;Note=Tetraspanin-11
TSPAN11	A1L157	28	92	1	253	Chain	ID=PRO_0000311905;Note=Tetraspanin-11
TSPAN11	A1L157	92	117	1	253	Chain	ID=PRO_0000311905;Note=Tetraspanin-11
TSPAN11	A1L157	152	205	1	253	Chain	ID=PRO_0000311905;Note=Tetraspanin-11
TSPAN11	A1L157	28	92	19	39	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN11	A1L157	28	92	19	39	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN11	A1L157	28	92	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN11	A1L157	28	92	63	83	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN11	A1L157	92	117	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN11	A1L157	92	117	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN11	A1L157	152	205	190	190	Natural variant	ID=VAR_037337;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2075333,PMID:15489334
TSPAN11	A1L157	152	205	190	190	Natural variant	ID=VAR_037337;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2075333,PMID:15489334
THBS2	P35442	492	550	19	1172	Chain	ID=PRO_0000035846;Note=Thrombospondin-2
THBS2	P35442	376	433	19	1172	Chain	ID=PRO_0000035846;Note=Thrombospondin-2
THBS2	P35442	297	344	19	1172	Chain	ID=PRO_0000035846;Note=Thrombospondin-2
THBS2	P35442	297	344	318	375	Domain	Note=VWFC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
THBS2	P35442	376	433	381	431	Domain	Note=TSP type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS2	P35442	492	550	437	492	Domain	Note=TSP type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS2	P35442	492	550	494	549	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS2	P35442	492	550	549	589	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS2	P35442	297	344	316	316	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THBS2	P35442	297	344	330	330	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THBS2	P35442	376	433	393	425	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
THBS2	P35442	376	433	397	430	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
THBS2	P35442	376	433	408	415	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
THBS2	P35442	492	550	506	543	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
THBS2	P35442	492	550	510	548	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
THBS2	P35442	492	550	521	533	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TSR1	Q2NL82	140	185	1	804	Chain	ID=PRO_0000311274;Note=Pre-rRNA-processing protein TSR1 homolog
TSR1	Q2NL82	140	185	81	248	Domain	Note=Bms1-type G
TTC37	Q6PGP7	1114	1187	2	1564	Chain	ID=PRO_0000251722;Note=Tetratricopeptide repeat protein 37
TTC37	Q6PGP7	859	878	2	1564	Chain	ID=PRO_0000251722;Note=Tetratricopeptide repeat protein 37
TTC37	Q6PGP7	30	78	2	1564	Chain	ID=PRO_0000251722;Note=Tetratricopeptide repeat protein 37
TTC37	Q6PGP7	30	78	6	39	Repeat	Note=TPR 1
TTC37	Q6PGP7	30	78	40	73	Repeat	Note=TPR 2
TTC37	Q6PGP7	859	878	826	860	Repeat	Note=TPR 14
TTC37	Q6PGP7	859	878	861	894	Repeat	Note=TPR 15
TTC37	Q6PGP7	859	878	860	878	Natural variant	ID=VAR_065297;Note=Found in a THES1 patient. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120949;Dbxref=PMID:21120949
TSPAN9	O75954	21	85	1	239	Chain	ID=PRO_0000219253;Note=Tetraspanin-9
TSPAN9	O75954	85	110	1	239	Chain	ID=PRO_0000219253;Note=Tetraspanin-9
TSPAN9	O75954	188	216	1	239	Chain	ID=PRO_0000219253;Note=Tetraspanin-9
TSPAN9	O75954	21	85	1	239	Chain	ID=PRO_0000219253;Note=Tetraspanin-9
TSPAN9	O75954	85	110	1	239	Chain	ID=PRO_0000219253;Note=Tetraspanin-9
TSPAN9	O75954	188	216	1	239	Chain	ID=PRO_0000219253;Note=Tetraspanin-9
TSPAN9	O75954	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	85	110	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	85	110	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	85	110	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	85	110	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	85	110	107	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	188	216	107	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	85	110	107	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	188	216	107	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	188	216	204	224	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	188	216	204	224	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN9	O75954	188	216	216	216	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN9	O75954	188	216	216	216	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTC27	Q6P3X3	132	179	1	843	Chain	ID=PRO_0000295096;Note=Tetratricopeptide repeat protein 27
TTC27	Q6P3X3	373	411	1	843	Chain	ID=PRO_0000295096;Note=Tetratricopeptide repeat protein 27
TTC27	Q6P3X3	443	484	1	843	Chain	ID=PRO_0000295096;Note=Tetratricopeptide repeat protein 27
TTC27	Q6P3X3	484	560	1	843	Chain	ID=PRO_0000295096;Note=Tetratricopeptide repeat protein 27
TTC27	Q6P3X3	560	593	1	843	Chain	ID=PRO_0000295096;Note=Tetratricopeptide repeat protein 27
TTC27	Q6P3X3	666	732	1	843	Chain	ID=PRO_0000295096;Note=Tetratricopeptide repeat protein 27
TTC27	Q6P3X3	443	484	453	486	Repeat	Note=TPR 1
TTC27	Q6P3X3	484	560	453	486	Repeat	Note=TPR 1
TTC27	Q6P3X3	484	560	492	525	Repeat	Note=TPR 2
TTC27	Q6P3X3	484	560	527	560	Repeat	Note=TPR 3
TTC27	Q6P3X3	560	593	527	560	Repeat	Note=TPR 3
TTC27	Q6P3X3	560	593	561	594	Repeat	Note=TPR 4
TTC27	Q6P3X3	443	484	476	476	Natural variant	ID=VAR_033207;Note=Y->C;Dbxref=dbSNP:rs2273660
TTC27	Q6P3X3	484	560	498	498	Natural variant	ID=VAR_061905;Note=T->M;Dbxref=dbSNP:rs34188947
TTC27	Q6P3X3	484	560	525	525	Natural variant	ID=VAR_033208;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2273664,PMID:14702039
TTC27	Q6P3X3	560	593	586	586	Natural variant	ID=VAR_052628;Note=R->H;Dbxref=dbSNP:rs17012268
TTC27	Q6P3X3	560	593	563	563	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TULP3	O75386	308	341	1	442	Chain	ID=PRO_0000186470;Note=Tubby-related protein 3
TULP3	O75386	308	341	190	442	Alternative sequence	ID=VSP_055763;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTBK2	Q6IQ55	232	274	1	1244	Chain	ID=PRO_0000234342;Note=Tau-tubulin kinase 2
TTBK2	Q6IQ55	179	201	1	1244	Chain	ID=PRO_0000234342;Note=Tau-tubulin kinase 2
TTBK2	Q6IQ55	144	179	1	1244	Chain	ID=PRO_0000234342;Note=Tau-tubulin kinase 2
TTBK2	Q6IQ55	232	274	21	284	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TTBK2	Q6IQ55	179	201	21	284	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TTBK2	Q6IQ55	144	179	21	284	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TTBK2	Q6IQ55	144	179	163	163	Mutagenesis	Note=Abolishes serine/threonine-protein kinase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21548880;Dbxref=PMID:21548880
TTBK2	Q6IQ55	179	201	181	181	Mutagenesis	Note=Impaired serine/threonine-protein kinase activity. R->E%2CA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21548880;Dbxref=PMID:21548880
TTBK2	Q6IQ55	179	201	184	184	Mutagenesis	Note=Impaired serine/threonine-protein kinase activity. A->E%2CG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21548880;Dbxref=PMID:21548880
TAF4B	Q92750	163	199	1	862	Chain	ID=PRO_0000118872;Note=Transcription initiation factor TFIID subunit 4B
TAF4B	Q92750	324	530	1	862	Chain	ID=PRO_0000118872;Note=Transcription initiation factor TFIID subunit 4B
TAF4B	Q92750	711	753	1	862	Chain	ID=PRO_0000118872;Note=Transcription initiation factor TFIID subunit 4B
TAF4B	Q92750	753	772	1	862	Chain	ID=PRO_0000118872;Note=Transcription initiation factor TFIID subunit 4B
TAF4B	Q92750	324	530	256	353	Domain	Note=TAFH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00440
TAF4B	Q92750	324	530	511	533	Region	Note=Required for interaction with P65/RELA
TAF4B	Q92750	711	753	722	787	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF4B	Q92750	753	772	722	787	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF4B	Q92750	324	530	516	556	Motif	Note=Nuclear export signal
TAF4B	Q92750	711	753	619	862	Alternative sequence	ID=VSP_022026;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16088961;Dbxref=PMID:16088961
TAF4B	Q92750	753	772	619	862	Alternative sequence	ID=VSP_022026;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16088961;Dbxref=PMID:16088961
TAF4B	Q92750	324	530	490	496	Sequence conflict	Note=SAGTTSD->FCWDHIC;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAF4B	Q92750	324	530	523	530	Sequence conflict	Note=QAVQVKQL->TGSSSKQLFSLFH;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAPT1	Q6NXT6	305	332	2	567	Chain	ID=PRO_0000328872;Note=Transmembrane anterior posterior transformation protein 1 homolog
TIMMDC1	Q9NPL8	199	235	1	285	Chain	ID=PRO_0000252478;Note=Complex I assembly factor TIMMDC1%2C mitochondrial
TIMMDC1	Q9NPL8	199	235	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMMDC1	Q9NPL8	199	235	217	217	Natural variant	ID=VAR_061572;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11092749,ECO:0000269|Ref.5;Dbxref=dbSNP:rs57168946,PMID:11092749
TIMMDC1	Q9NPL8	199	235	213	213	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TREH	O43280	175	205	24	556	Chain	ID=PRO_0000012051;Note=Trehalase
TREH	O43280	175	205	175	176	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P13482
TREH	O43280	175	205	175	206	Alternative sequence	ID=VSP_035440;Note=In isoform 2. WDSYWVMEGLLLSEMAETVKGMLQNFLDLVKT->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRIM4	Q9C037	189	266	1	500	Chain	ID=PRO_0000056200;Note=E3 ubiquitin-protein ligase TRIM4
TRIM4	Q9C037	131	157	1	500	Chain	ID=PRO_0000056200;Note=E3 ubiquitin-protein ligase TRIM4
TRIM4	Q9C037	189	266	212	253	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM4	Q9C037	131	157	132	157	Alternative sequence	ID=VSP_010197;Note=In isoform Beta and isoform Gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11331580,ECO:0000303|PubMed:15489334;Dbxref=PMID:11331580,PMID:15489334
TRIM4	Q9C037	131	157	154	154	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRANK1	O15050	1585	1634	1	2925	Chain	ID=PRO_0000348238;Note=TPR and ankyrin repeat-containing protein 1
TRANK1	O15050	513	1472	1	2925	Chain	ID=PRO_0000348238;Note=TPR and ankyrin repeat-containing protein 1
TRANK1	O15050	315	369	1	2925	Chain	ID=PRO_0000348238;Note=TPR and ankyrin repeat-containing protein 1
TRANK1	O15050	258	315	1	2925	Chain	ID=PRO_0000348238;Note=TPR and ankyrin repeat-containing protein 1
TRANK1	O15050	140	168	1	2925	Chain	ID=PRO_0000348238;Note=TPR and ankyrin repeat-containing protein 1
TRANK1	O15050	140	168	168	198	Repeat	Note=ANK 1
TRANK1	O15050	258	315	240	276	Repeat	Note=ANK 3
TRANK1	O15050	513	1472	497	518	Repeat	Note=ANK 5
TRANK1	O15050	513	1472	546	575	Repeat	Note=ANK 6
TRANK1	O15050	513	1472	1076	1115	Compositional bias	Note=Glu-rich
TRANK1	O15050	140	168	153	153	Natural variant	ID=VAR_061021;Note=P->L;Dbxref=dbSNP:rs17201603
TRANK1	O15050	513	1472	703	703	Natural variant	ID=VAR_046117;Note=P->L;Dbxref=dbSNP:rs17201603
TRANK1	O15050	513	1472	1090	1090	Natural variant	ID=VAR_046118;Note=E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9205841;Dbxref=dbSNP:rs11712950,PMID:14702039,PMID:9205841
TRANK1	O15050	513	1472	1286	1286	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRPC7	Q9HCX4	321	376	1	862	Chain	ID=PRO_0000215324;Note=Short transient receptor potential channel 7
TRPC7	Q9HCX4	260	321	1	862	Chain	ID=PRO_0000215324;Note=Short transient receptor potential channel 7
TRPC7	Q9HCX4	321	376	1	351	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC7	Q9HCX4	260	321	1	351	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC7	Q9HCX4	321	376	352	372	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC7	Q9HCX4	321	376	373	383	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC7	Q9HCX4	321	376	260	375	Alternative sequence	ID=VSP_043035;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TRPC7	Q9HCX4	260	321	260	375	Alternative sequence	ID=VSP_043035;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TRPC7	Q9HCX4	260	321	260	320	Alternative sequence	ID=VSP_044897;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TRPV2	Q9Y5S1	308	365	1	764	Chain	ID=PRO_0000215342;Note=Transient receptor potential cation channel subfamily V member 2
TRPV2	Q9Y5S1	308	365	1	390	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPV2	Q9Y5S1	308	365	293	319	Repeat	Note=ANK 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00023,ECO:0000269|PubMed:16882997;Dbxref=PMID:16882997
TRPV2	Q9Y5S1	308	365	1	388	Region	Note=Required for interaction with SLC50A1;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRPV2	Q9Y5S1	308	365	307	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F37
WDR1	O75083	465	523	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	428	465	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	212	239	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	186	212	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	465	523	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	428	465	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	212	239	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	186	212	1	606	Chain	ID=PRO_0000051341;Note=WD repeat-containing protein 1
WDR1	O75083	212	239	180	218	Repeat	Note=WD 5
WDR1	O75083	186	212	180	218	Repeat	Note=WD 5
WDR1	O75083	212	239	180	218	Repeat	Note=WD 5
WDR1	O75083	186	212	180	218	Repeat	Note=WD 5
WDR1	O75083	212	239	224	263	Repeat	Note=WD 6
WDR1	O75083	212	239	224	263	Repeat	Note=WD 6
WDR1	O75083	465	523	432	474	Repeat	Note=WD 10
WDR1	O75083	428	465	432	474	Repeat	Note=WD 10
WDR1	O75083	465	523	432	474	Repeat	Note=WD 10
WDR1	O75083	428	465	432	474	Repeat	Note=WD 10
WDR1	O75083	465	523	480	518	Repeat	Note=WD 11
WDR1	O75083	465	523	480	518	Repeat	Note=WD 11
WDR1	O75083	465	523	523	561	Repeat	Note=WD 12
WDR1	O75083	465	523	523	561	Repeat	Note=WD 12
WDR1	O75083	212	239	238	238	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:15592455,ECO:0000244|PubMed:19690332;Dbxref=PMID:15592455,PMID:19690332
WDR1	O75083	212	239	238	238	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:15592455,ECO:0000244|PubMed:19690332;Dbxref=PMID:15592455,PMID:19690332
WDR1	O75083	465	523	480	480	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
WDR1	O75083	465	523	480	480	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
WDR1	O75083	186	212	47	186	Alternative sequence	ID=VSP_012926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR1	O75083	186	212	47	186	Alternative sequence	ID=VSP_012926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLAU	P00749	28	64	21	431	Chain	ID=PRO_0000028318;Note=Urokinase-type plasminogen activator
PLAU	P00749	276	323	21	431	Chain	ID=PRO_0000028318;Note=Urokinase-type plasminogen activator
PLAU	P00749	28	64	21	177	Chain	ID=PRO_0000028319;Note=Urokinase-type plasminogen activator long chain A
PLAU	P00749	276	323	179	431	Chain	ID=PRO_0000028321;Note=Urokinase-type plasminogen activator chain B
PLAU	P00749	28	64	27	63	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
PLAU	P00749	276	323	179	424	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
PLAU	P00749	28	64	34	57	Region	Note=Binds urokinase plasminogen activator surface receptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PLAU	P00749	276	323	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9151681;Dbxref=PMID:9151681
PLAU	P00749	28	64	38	38	Glycosylation	Note=O-linked (Fuc) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2023947;Dbxref=PMID:2023947
PLAU	P00749	276	323	322	322	Glycosylation	ID=CAR_000026;Note=N-linked (GlcNAc...) asparagine
PLAU	P00749	28	64	31	39	Disulfide bond	.
PLAU	P00749	28	64	33	51	Disulfide bond	.
PLAU	P00749	28	64	53	62	Disulfide bond	.
PLAU	P00749	276	323	168	299	Disulfide bond	Note=Interchain (between A and B chains)
PLAU	P00749	276	323	217	288	Disulfide bond	.
PLAU	P00749	276	323	313	382	Disulfide bond	.
PLAU	P00749	28	64	1	29	Alternative sequence	ID=VSP_038368;Note=In isoform 2. MRALLARLLLCVLVVSDSKGSNELHQVPS->MVFHLRTRYEQA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLAU	P00749	276	323	323	323	Mutagenesis	Note=Abolishes phosphorylation%2C proadhesive function and ability to induce chemotactic response%3B when associated with E-158. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9151681;Dbxref=PMID:9151681
PLAU	P00749	28	64	34	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1URK
PLAU	P00749	28	64	38	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FD6
PLAU	P00749	28	64	43	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FD6
PLAU	P00749	28	64	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FD6
PLAU	P00749	28	64	57	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FD6
PLAU	P00749	28	64	64	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FD6
PLAU	P00749	276	323	277	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JNI
PLAU	P00749	276	323	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LMW
PLAU	P00749	276	323	312	318	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JNI
USP9X	Q93008	145	218	1	2570	Chain	ID=PRO_0000080689;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-X
USP9X	Q93008	387	438	1	2570	Chain	ID=PRO_0000080689;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-X
USP9X	Q93008	1186	1228	1	2570	Chain	ID=PRO_0000080689;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-X
USP9X	Q93008	1362	1411	1	2570	Chain	ID=PRO_0000080689;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-X
USP9X	Q93008	1672	1729	1	2570	Chain	ID=PRO_0000080689;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-X
USP9X	Q93008	2188	2250	1	2570	Chain	ID=PRO_0000080689;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-X
USP9X	Q93008	1672	1729	1557	1956	Domain	Note=USP
USP9X	Q93008	145	218	148	154	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP9X	Q93008	1362	1411	1400	1400	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
UMODL1	Q5DID0	263	310	22	1318	Chain	ID=PRO_0000228127;Note=Uromodulin-like 1
UMODL1	Q5DID0	263	310	22	1272	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UMODL1	Q5DID0	263	310	264	313	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
UMODL1	Q5DID0	263	310	274	274	Natural variant	ID=VAR_025669;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16026467;Dbxref=dbSNP:rs17114359,PMID:16026467
UMODL1	Q5DID0	263	310	274	274	Natural variant	ID=VAR_025670;Note=N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16026467;Dbxref=dbSNP:rs17114359,PMID:16026467
USHBP1	Q8N6Y0	349	406	1	703	Chain	ID=PRO_0000252109;Note=Usher syndrome type-1C protein-binding protein 1
USHBP1	Q8N6Y0	349	406	69	703	Alternative sequence	ID=VSP_052080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11311560;Dbxref=PMID:11311560
USHBP1	Q8N6Y0	349	406	400	400	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
USF1	P22415	58	92	1	310	Chain	ID=PRO_0000127496;Note=Upstream stimulatory factor 1
USF1	P22415	58	92	1	310	Chain	ID=PRO_0000127496;Note=Upstream stimulatory factor 1
USF1	P22415	58	92	1	59	Alternative sequence	ID=VSP_047740;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
USF1	P22415	58	92	1	59	Alternative sequence	ID=VSP_047740;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
UTP14A	Q9BVJ6	127	179	1	771	Chain	ID=PRO_0000065733;Note=U3 small nucleolar RNA-associated protein 14 homolog A
UTP14A	Q9BVJ6	127	179	13	180	Alternative sequence	ID=VSP_014476;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
UTP14A	Q9BVJ6	127	179	128	179	Alternative sequence	ID=VSP_046389;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UVRAG	Q9P2Y5	90	144	1	699	Chain	ID=PRO_0000065750;Note=UV radiation resistance-associated gene protein
UVRAG	Q9P2Y5	144	169	1	699	Chain	ID=PRO_0000065750;Note=UV radiation resistance-associated gene protein
UVRAG	Q9P2Y5	90	144	44	128	Domain	Note=C2
UVRAG	Q9P2Y5	90	144	1	372	Alternative sequence	ID=VSP_056176;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UVRAG	Q9P2Y5	144	169	1	372	Alternative sequence	ID=VSP_056176;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP6V1A	P38606	142	188	1	617	Chain	ID=PRO_0000144560;Note=V-type proton ATPase catalytic subunit A
WDR11	Q9BZH6	117	175	1	1224	Chain	ID=PRO_0000050889;Note=WD repeat-containing protein 11
WDR11	Q9BZH6	117	175	111	154	Repeat	Note=WD 2
TSPAN6	O43657	195	223	1	245	Chain	ID=PRO_0000219246;Note=Tetraspanin-6
TSPAN6	O43657	150	195	1	245	Chain	ID=PRO_0000219246;Note=Tetraspanin-6
TSPAN6	O43657	195	223	115	208	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN6	O43657	150	195	115	208	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN6	O43657	195	223	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
THBS3	P49746	480	516	23	956	Chain	ID=PRO_0000035849;Note=Thrombospondin-3
THBS3	P49746	443	480	23	956	Chain	ID=PRO_0000035849;Note=Thrombospondin-3
THBS3	P49746	26	95	23	956	Chain	ID=PRO_0000035849;Note=Thrombospondin-3
THBS3	P49746	26	95	23	193	Domain	Note=Laminin G-like
THBS3	P49746	443	480	414	456	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS3	P49746	480	516	457	491	Repeat	Note=TSP type-3 1
THBS3	P49746	443	480	457	491	Repeat	Note=TSP type-3 1
THBS3	P49746	480	516	492	527	Repeat	Note=TSP type-3 2
THBS3	P49746	443	480	444	455	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS3	P49746	443	480	471	478	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS3	P49746	480	516	483	503	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TSPAN15	O95858	94	119	1	294	Chain	ID=PRO_0000219263;Note=Tetraspanin-15
TSPAN15	O95858	119	151	1	294	Chain	ID=PRO_0000219263;Note=Tetraspanin-15
TSPAN15	O95858	151	190	1	294	Chain	ID=PRO_0000219263;Note=Tetraspanin-15
TSPAN15	O95858	190	206	1	294	Chain	ID=PRO_0000219263;Note=Tetraspanin-15
TSPAN15	O95858	206	245	1	294	Chain	ID=PRO_0000219263;Note=Tetraspanin-15
TSPAN15	O95858	94	119	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	94	119	115	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	119	151	115	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	151	190	115	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	190	206	115	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	206	245	115	235	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	206	245	236	256	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	94	119	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	151	190	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	206	245	230	230	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN15	O95858	206	245	236	236	Sequence conflict	Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRSS16	Q9NQE7	239	336	25	514	Chain	ID=PRO_0000027320;Note=Thymus-specific serine protease
PRSS16	Q9NQE7	383	443	25	514	Chain	ID=PRO_0000027320;Note=Thymus-specific serine protease
PRSS16	Q9NQE7	239	336	321	321	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUB	P50607	84	132	1	506	Chain	ID=PRO_0000186463;Note=Tubby protein homolog
TUB	P50607	132	188	1	506	Chain	ID=PRO_0000186463;Note=Tubby protein homolog
TTLL1	O95922	297	326	1	423	Chain	ID=PRO_0000212438;Note=Probable tubulin polyglutamylase TTLL1
TTLL1	O95922	249	297	1	423	Chain	ID=PRO_0000212438;Note=Probable tubulin polyglutamylase TTLL1
TTLL1	O95922	168	212	1	423	Chain	ID=PRO_0000212438;Note=Probable tubulin polyglutamylase TTLL1
TTLL1	O95922	297	326	1	367	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL1	O95922	249	297	1	367	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL1	O95922	168	212	1	367	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL1	O95922	168	212	181	184	Nucleotide binding	Note=ATP binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZT98
TTLL1	O95922	168	212	194	194	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZT98
TTLL1	O95922	168	212	196	196	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZT98
TTLL1	O95922	297	326	60	423	Alternative sequence	ID=VSP_006672;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11054573,ECO:0000303|PubMed:12529303;Dbxref=PMID:11054573,PMID:12529303
TTLL1	O95922	249	297	60	423	Alternative sequence	ID=VSP_006672;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11054573,ECO:0000303|PubMed:12529303;Dbxref=PMID:11054573,PMID:12529303
TTLL1	O95922	168	212	60	423	Alternative sequence	ID=VSP_006672;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11054573,ECO:0000303|PubMed:12529303;Dbxref=PMID:11054573,PMID:12529303
TTLL1	O95922	297	326	298	326	Alternative sequence	ID=VSP_011825;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
TTLL1	O95922	168	212	168	168	Natural variant	ID=VAR_052409;Note=S->L;Dbxref=dbSNP:rs6003030
TVP23B	Q9NYZ1	154	197	1	205	Chain	ID=PRO_0000212828;Note=Golgi apparatus membrane protein TVP23 homolog B
TVP23B	Q9NYZ1	154	197	152	172	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYMP	P19971	139	172	11	482	Chain	ID=PRO_0000035875;Note=Thymidine phosphorylase
TYMP	P19971	139	172	11	482	Chain	ID=PRO_0000035875;Note=Thymidine phosphorylase
TYMP	P19971	139	172	11	482	Chain	ID=PRO_0000035875;Note=Thymidine phosphorylase
TYMP	P19971	139	172	145	145	Natural variant	ID=VAR_007643;Note=In MTDPS1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9924029;Dbxref=dbSNP:rs121913037,PMID:9924029
TYMP	P19971	139	172	145	145	Natural variant	ID=VAR_007643;Note=In MTDPS1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9924029;Dbxref=dbSNP:rs121913037,PMID:9924029
TYMP	P19971	139	172	145	145	Natural variant	ID=VAR_007643;Note=In MTDPS1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9924029;Dbxref=dbSNP:rs121913037,PMID:9924029
TYMP	P19971	139	172	153	153	Natural variant	ID=VAR_007644;Note=In MTDPS1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9924029;Dbxref=dbSNP:rs121913038,PMID:9924029
TYMP	P19971	139	172	153	153	Natural variant	ID=VAR_007644;Note=In MTDPS1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9924029;Dbxref=dbSNP:rs121913038,PMID:9924029
TYMP	P19971	139	172	153	153	Natural variant	ID=VAR_007644;Note=In MTDPS1. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9924029;Dbxref=dbSNP:rs121913038,PMID:9924029
TYMP	P19971	139	172	139	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	139	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	139	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	154	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	154	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	154	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	170	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	170	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
TYMP	P19971	139	172	170	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOU
DCT	P40126	288	347	24	519	Chain	ID=PRO_0000035892;Note=L-dopachrome tautomerase
DCT	P40126	288	347	24	472	Topological domain	Note=Lumenal%2C melanosome;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCT	P40126	288	347	300	300	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCT	P40126	288	347	342	342	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
U2AF1	Q01081	161	191	2	240	Chain	ID=PRO_0000081994;Note=Splicing factor U2AF 35 kDa subunit
U2AF1	Q01081	83	116	2	240	Chain	ID=PRO_0000081994;Note=Splicing factor U2AF 35 kDa subunit
U2AF1	Q01081	83	116	65	147	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
U2AF1	Q01081	161	191	149	176	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
U2AF1	Q01081	161	191	178	240	Compositional bias	Note=Arg/Gly/Ser-rich (RS domain)
U2AF1	Q01081	161	191	165	165	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
U2AF1	Q01081	161	191	76	240	Alternative sequence	ID=VSP_042667;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
U2AF1	Q01081	83	116	76	240	Alternative sequence	ID=VSP_042667;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
U2AF1	Q01081	83	116	64	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JMT
U2AF1	Q01081	83	116	96	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JMT
U2AF1	Q01081	83	116	104	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JMT
U2AF2	P26368	62	76	2	475	Chain	ID=PRO_0000081988;Note=Splicing factor U2AF 65 kDa subunit
U2AF2	P26368	162	201	2	475	Chain	ID=PRO_0000081988;Note=Splicing factor U2AF 65 kDa subunit
U2AF2	P26368	315	348	2	475	Chain	ID=PRO_0000081988;Note=Splicing factor U2AF 65 kDa subunit
U2AF2	P26368	162	201	149	231	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
U2AF2	P26368	315	348	259	337	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
U2AF2	P26368	62	76	2	93	Region	Note=Required for interaction with PRPF19;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21536736;Dbxref=PMID:21536736
U2AF2	P26368	62	76	27	62	Compositional bias	Note=Arg/Ser-rich (RS domain)
U2AF2	P26368	62	76	70	70	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
U2AF2	P26368	62	76	70	70	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
U2AF2	P26368	315	348	345	348	Alternative sequence	ID=VSP_035414;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
U2AF2	P26368	162	201	162	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5W0G
U2AF2	P26368	162	201	180	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5W0G
U2AF2	P26368	162	201	185	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5W0G
U2AF2	P26368	162	201	193	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EV3
U2AF2	P26368	162	201	197	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5W0G
U2AF2	P26368	315	348	310	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5W0H
U2AF2	P26368	315	348	326	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2U2F
U2AF2	P26368	315	348	331	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5W0H
U2AF2	P26368	315	348	335	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EV3
UBE2N	P61088	92	139	1	152	Chain	ID=PRO_0000082502;Note=Ubiquitin-conjugating enzyme E2 N
UBE2N	P61088	92	139	92	92	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16112642,ECO:0000269|PubMed:16122702;Dbxref=PMID:16112642,PMID:16122702
UBE2N	P61088	92	139	92	92	Mutagenesis	Note=No ISGylation. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16112642,ECO:0000269|PubMed:16122702;Dbxref=PMID:16112642,PMID:16122702
UBE2N	P61088	92	139	94	94	Mutagenesis	Note=No effect on ISGylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16112642;Dbxref=PMID:16112642
UBE2N	P61088	92	139	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONM
UBE2N	P61088	92	139	101	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2N	P61088	92	139	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2N	P61088	92	139	124	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2N	P61088	92	139	133	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
RARRES1	P49788	224	245	1	294	Chain	ID=PRO_0000191346;Note=Retinoic acid receptor responder protein 1
RARRES1	P49788	224	245	43	294	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RARRES1	P49788	224	245	225	228	Alternative sequence	ID=VSP_010697;Note=In isoform 1. KTND->VRKT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8601727;Dbxref=PMID:8601727
RARRES1	P49788	224	245	229	294	Alternative sequence	ID=VSP_010698;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8601727;Dbxref=PMID:8601727
TLE3	Q04726	255	306	1	772	Chain	ID=PRO_0000051280;Note=Transducin-like enhancer protein 3
TLE3	Q04726	255	306	200	268	Region	Note=CcN domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04724
TLE3	Q04726	255	306	269	452	Region	Note=SP domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04724
TLE3	Q04726	255	306	259	259	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692
TLE3	Q04726	255	306	263	263	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
TLE3	Q04726	255	306	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
TLE3	Q04726	255	306	275	275	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04727
TLE3	Q04726	255	306	286	286	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
TLL2	Q9Y6L7	121	173	26	149	Propeptide	ID=PRO_0000046036;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10479448;Dbxref=PMID:10479448
TLL2	Q9Y6L7	95	121	26	149	Propeptide	ID=PRO_0000046036;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10479448;Dbxref=PMID:10479448
TLL2	Q9Y6L7	121	173	150	1015	Chain	ID=PRO_0000046037;Note=Tolloid-like protein 2
TLL2	Q9Y6L7	121	173	149	349	Domain	Note=Peptidase M12A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01211
TLL2	Q9Y6L7	121	173	171	171	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45A	Q9NWC5	63	134	1	275	Chain	ID=PRO_0000072569;Note=Transmembrane protein 45A
TMEM45A	Q9NWC5	63	134	51	71	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45A	Q9NWC5	63	134	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	1	275	Chain	ID=PRO_0000271199;Note=Transmembrane protein 45B
TMEM45B	Q96B21	59	128	1	275	Chain	ID=PRO_0000271199;Note=Transmembrane protein 45B
TMEM45B	Q96B21	59	128	47	67	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	47	67	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	94	114	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM45B	Q96B21	59	128	59	59	Natural variant	ID=VAR_029866;Note=T->I;Dbxref=dbSNP:rs558813
TMEM45B	Q96B21	59	128	59	59	Natural variant	ID=VAR_029866;Note=T->I;Dbxref=dbSNP:rs558813
TMEM116	Q8NCL8	30	57	1	245	Chain	ID=PRO_0000251195;Note=Transmembrane protein 116
TMEM116	Q8NCL8	30	57	24	44	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS11D	O60235	158	171	1	186	Chain	ID=PRO_0000027885;Note=Transmembrane protease serine 11D non-catalytic chain
TMPRSS11D	O60235	158	171	42	418	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS11D	O60235	158	171	46	163	Domain	Note=SEA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
TNFAIP3	P21580	211	268	2	790	Chain	ID=PRO_0000188791;Note=Tumor necrosis factor alpha-induced protein 3
TNFAIP3	P21580	211	268	2	439	Chain	ID=PRO_0000418127;Note=A20p50
TNFAIP3	P21580	211	268	92	263	Domain	Note=OTU;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00139
TNFAIP3	P21580	211	268	58	300	Region	Note=TRAF-binding
TNFAIP3	P21580	211	268	224	227	Region	Note=Interaction with ubiquitin;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNFAIP3	P21580	211	268	256	256	Active site	Note=Proton acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:18164316;Dbxref=PMID:18164316
TNFAIP3	P21580	211	268	243	243	Natural variant	ID=VAR_076302;Note=In AISBL%3B increases inflammatory cytokine secretion%3B increases NF-kappaB signaling. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27175295;Dbxref=PMID:27175295
TNFAIP3	P21580	211	268	224	224	Mutagenesis	Note=Strongly reduced 'Lys-48' deubiquitinase activity. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18164316;Dbxref=PMID:18164316
TNFAIP3	P21580	211	268	227	227	Mutagenesis	Note=Strongly reduced 'Lys-48' deubiquitinase activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18164316;Dbxref=PMID:18164316
TNFAIP3	P21580	211	268	256	256	Mutagenesis	Note=Loss of deubiquitinase activity. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17961127,ECO:0000269|PubMed:27732584;Dbxref=PMID:17961127,PMID:27732584
TNFAIP3	P21580	211	268	207	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZJE
TNFAIP3	P21580	211	268	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LRX
TNFAIP3	P21580	211	268	218	220	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LRX
TNFAIP3	P21580	211	268	221	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LRX
TNFAIP3	P21580	211	268	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZJE
TNFAIP3	P21580	211	268	240	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZJE
TNFAIP3	P21580	211	268	248	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZJE
TNFAIP3	P21580	211	268	256	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZJE
TNFAIP3	P21580	211	268	267	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZJG
TNFRSF12A	Q9NP84	31	66	28	129	Chain	ID=PRO_0000034611;Note=Tumor necrosis factor receptor superfamily member 12A
TNFRSF12A	Q9NP84	31	66	28	80	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF12A	Q9NP84	31	66	36	67	Repeat	Note=TNFR-Cys%3B atypical
TNFRSF12A	Q9NP84	31	66	36	49	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19241374;Dbxref=PMID:19241374
TNFRSF12A	Q9NP84	31	66	52	67	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19241374;Dbxref=PMID:19241374
TNFRSF12A	Q9NP84	31	66	55	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19241374;Dbxref=PMID:19241374
TNFRSF12A	Q9NP84	31	66	33	67	Alternative sequence	ID=VSP_006519;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TNFRSF12A	Q9NP84	31	66	30	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQP
TNFRSF12A	Q9NP84	31	66	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQP
TNFRSF12A	Q9NP84	31	66	44	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQP
TNFRSF12A	Q9NP84	31	66	48	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQP
TNFRSF12A	Q9NP84	31	66	52	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQP
TNFRSF12A	Q9NP84	31	66	62	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EQP
TNFSF13	O75888	112	128	105	250	Chain	ID=PRO_0000034525;Note=Tumor necrosis factor ligand superfamily member 13
TNFSF13	O75888	112	128	124	124	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFSF13	O75888	112	128	86	113	Alternative sequence	ID=VSP_043154;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNFSF13	O75888	112	128	87	114	Alternative sequence	ID=VSP_046726;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNFSF13	O75888	112	128	113	129	Alternative sequence	ID=VSP_006450;Note=In isoform Beta. KQHSVLHLVPINATSKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10706119;Dbxref=PMID:10706119
TNFSF13	O75888	112	128	117	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZCH
TNPO1	Q92973	68	118	1	898	Chain	ID=PRO_0000120765;Note=Transportin-1
TNPO1	Q92973	226	267	1	898	Chain	ID=PRO_0000120765;Note=Transportin-1
TNPO1	Q92973	383	434	1	898	Chain	ID=PRO_0000120765;Note=Transportin-1
TNPO1	Q92973	567	596	1	898	Chain	ID=PRO_0000120765;Note=Transportin-1
TNPO1	Q92973	714	747	1	898	Chain	ID=PRO_0000120765;Note=Transportin-1
TNPO1	Q92973	747	779	1	898	Chain	ID=PRO_0000120765;Note=Transportin-1
TNPO1	Q92973	68	118	41	109	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
TNPO1	Q92973	68	118	51	89	Repeat	Note=HEAT 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	68	118	98	131	Repeat	Note=HEAT 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	226	267	224	251	Repeat	Note=HEAT 6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	226	267	263	290	Repeat	Note=HEAT 7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	383	434	306	397	Repeat	Note=HEAT 8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	383	434	405	433	Repeat	Note=HEAT 9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	567	596	568	606	Repeat	Note=HEAT 13;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	714	747	715	748	Repeat	Note=HEAT 16;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	747	779	715	748	Repeat	Note=HEAT 16;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	747	779	756	791	Repeat	Note=HEAT 17;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10353245;Dbxref=PMID:10353245
TNPO1	Q92973	714	747	738	738	Site	Note=Important for interaction with cargo nuclear localization signals;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571
TNPO1	Q92973	68	118	69	118	Alternative sequence	ID=VSP_038029;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNPO1	Q92973	714	747	738	738	Mutagenesis	Note=Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571
TNPO1	Q92973	68	118	104	104	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNPO1	Q92973	68	118	70	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	68	118	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	68	118	88	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	68	118	93	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	68	118	105	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	68	118	112	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	226	267	221	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	226	267	237	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	226	267	256	258	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	226	267	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	226	267	262	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	383	434	383	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	383	434	399	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5K
TNPO1	Q92973	383	434	403	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5N
TNPO1	Q92973	383	434	406	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	383	434	416	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QBK
TNPO1	Q92973	383	434	419	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	567	596	567	569	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	567	596	570	578	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	567	596	588	594	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	714	747	713	720	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	714	747	727	729	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO6
TNPO1	Q92973	714	747	730	747	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	747	779	730	747	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	747	779	748	755	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	747	779	756	767	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO1	Q92973	747	779	768	770	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YVH
TNPO1	Q92973	747	779	772	787	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDD
TNPO2	O14787	585	621	1	897	Chain	ID=PRO_0000120767;Note=Transportin-2
TNPO2	O14787	556	585	1	897	Chain	ID=PRO_0000120767;Note=Transportin-2
TNPO2	O14787	372	423	1	897	Chain	ID=PRO_0000120767;Note=Transportin-2
TNPO2	O14787	585	621	1	897	Chain	ID=PRO_0000120767;Note=Transportin-2
TNPO2	O14787	556	585	1	897	Chain	ID=PRO_0000120767;Note=Transportin-2
TNPO2	O14787	372	423	1	897	Chain	ID=PRO_0000120767;Note=Transportin-2
TNPO2	O14787	372	423	296	386	Repeat	Note=HEAT 8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	372	423	296	386	Repeat	Note=HEAT 8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	372	423	394	422	Repeat	Note=HEAT 9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	372	423	394	422	Repeat	Note=HEAT 9;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	585	621	557	595	Repeat	Note=HEAT 13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	556	585	557	595	Repeat	Note=HEAT 13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	585	621	557	595	Repeat	Note=HEAT 13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	556	585	557	595	Repeat	Note=HEAT 13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	585	621	603	654	Repeat	Note=HEAT 14;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	585	621	603	654	Repeat	Note=HEAT 14;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q92973
TNPO2	O14787	372	423	398	401	Sequence conflict	Note=LLKG->YQS;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNPO2	O14787	372	423	398	401	Sequence conflict	Note=LLKG->YQS;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNPO2	O14787	585	621	608	608	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNPO2	O14787	585	621	608	608	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNFRSF11A	Q9Y6Q6	94	142	30	616	Chain	ID=PRO_0000034585;Note=Tumor necrosis factor receptor superfamily member 11A
TNFRSF11A	Q9Y6Q6	205	243	30	616	Chain	ID=PRO_0000034585;Note=Tumor necrosis factor receptor superfamily member 11A
TNFRSF11A	Q9Y6Q6	94	142	30	212	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11A	Q9Y6Q6	205	243	30	212	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11A	Q9Y6Q6	205	243	213	233	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11A	Q9Y6Q6	205	243	234	616	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11A	Q9Y6Q6	94	142	71	112	Repeat	Note=TNFR-Cys 2
TNFRSF11A	Q9Y6Q6	94	142	114	151	Repeat	Note=TNFR-Cys 3
TNFRSF11A	Q9Y6Q6	94	142	133	133	Metal binding	Note=Sodium%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF11A	Q9Y6Q6	94	142	134	134	Metal binding	Note=Sodium%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF11A	Q9Y6Q6	94	142	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11A	Q9Y6Q6	94	142	92	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF11A	Q9Y6Q6	94	142	114	127	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF11A	Q9Y6Q6	94	142	124	126	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF11A	Q9Y6Q6	94	142	133	151	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF11A	Q9Y6Q6	205	243	206	522	Alternative sequence	ID=VSP_046901;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.3,ECO:0000303|Ref.4
TNFRSF11A	Q9Y6Q6	94	142	129	129	Natural variant	ID=VAR_046789;Note=In OPTB7%3B a patient with osteoclast-poor osteopetrosis. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18606301;Dbxref=dbSNP:rs121908657,PMID:18606301
TNFRSF11A	Q9Y6Q6	94	142	141	141	Natural variant	ID=VAR_046790;Note=H->Y;Dbxref=dbSNP:rs35211496
TOM1	O60784	122	167	1	492	Chain	ID=PRO_0000072628;Note=Target of Myb protein 1
TOM1	O60784	122	167	20	152	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
TOM1	O60784	122	167	160	160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
TOM1	O60784	122	167	164	164	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
TOM1	O60784	122	167	123	167	Alternative sequence	ID=VSP_038365;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1	O60784	122	167	111	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ELK
TOM1	O60784	122	167	135	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ELK
TOP3B	O95985	551	601	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	450	508	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	246	284	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	103	128	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	551	601	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	450	508	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	246	284	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	103	128	1	862	Chain	ID=PRO_0000145192;Note=DNA topoisomerase 3-beta-1
TOP3B	O95985	103	128	3	153	Domain	Note=Toprim;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995
TOP3B	O95985	103	128	3	153	Domain	Note=Toprim;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995
TOP3B	O95985	103	128	98	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	103	128	98	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	103	128	110	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	103	128	110	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	103	128	120	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	103	128	120	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	239	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	239	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	254	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	254	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	267	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	267	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	276	279	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	276	279	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	282	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	246	284	282	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	451	454	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	451	454	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	457	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	457	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	475	487	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	475	487	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	496	505	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	450	508	496	505	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	539	551	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	539	551	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	553	555	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	553	555	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	559	572	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	559	572	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	578	598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	578	598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	601	610	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TOP3B	O95985	551	601	601	610	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVC
TSPAN19	P0C672	198	226	1	248	Chain	ID=PRO_0000317254;Note=Putative tetraspanin-19
TSPAN19	P0C672	113	150	1	248	Chain	ID=PRO_0000317254;Note=Putative tetraspanin-19
TSPAN12	O95859	156	204	1	305	Chain	ID=PRO_0000219257;Note=Tetraspanin-12
TSPAN12	O95859	95	120	1	305	Chain	ID=PRO_0000219257;Note=Tetraspanin-12
TSPAN12	O95859	156	204	1	305	Chain	ID=PRO_0000219257;Note=Tetraspanin-12
TSPAN12	O95859	95	120	1	305	Chain	ID=PRO_0000219257;Note=Tetraspanin-12
TSPAN12	O95859	95	120	90	110	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN12	O95859	95	120	90	110	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN12	O95859	156	204	111	224	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN12	O95859	95	120	111	224	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN12	O95859	156	204	111	224	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN12	O95859	95	120	111	224	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN12	O95859	95	120	1	120	Alternative sequence	ID=VSP_038525;Note=In isoform 2. MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGSLLVIFCVELACGVWTYEQELM->MAHKLLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN12	O95859	95	120	1	120	Alternative sequence	ID=VSP_038525;Note=In isoform 2. MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGSLLVIFCVELACGVWTYEQELM->MAHKLLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN12	O95859	95	120	101	101	Natural variant	ID=VAR_063576;Note=In EVR5. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20159112;Dbxref=dbSNP:rs267607152,PMID:20159112
TSPAN12	O95859	95	120	101	101	Natural variant	ID=VAR_063576;Note=In EVR5. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20159112;Dbxref=dbSNP:rs267607152,PMID:20159112
TSPAN12	O95859	156	204	188	188	Natural variant	ID=VAR_063577;Note=In EVR5. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20159111;Dbxref=dbSNP:rs267607151,PMID:20159111
TSPAN12	O95859	156	204	188	188	Natural variant	ID=VAR_063577;Note=In EVR5. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20159111;Dbxref=dbSNP:rs267607151,PMID:20159111
TTC38	Q5R3I4	122	179	2	469	Chain	ID=PRO_0000321530;Note=Tetratricopeptide repeat protein 38
TTC38	Q5R3I4	205	245	2	469	Chain	ID=PRO_0000321530;Note=Tetratricopeptide repeat protein 38
TTC38	Q5R3I4	122	179	108	141	Repeat	Note=TPR 1
TTC38	Q5R3I4	205	245	180	213	Repeat	Note=TPR 2
TTC38	Q5R3I4	205	245	243	243	Natural variant	ID=VAR_039344;Note=F->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs130642,PMID:14702039,PMID:15489334
TULP1	O00294	200	239	1	542	Chain	ID=PRO_0000186466;Note=Tubby-related protein 1
TULP1	O00294	116	166	1	542	Chain	ID=PRO_0000186466;Note=Tubby-related protein 1
TULP1	O00294	63	116	1	542	Chain	ID=PRO_0000186466;Note=Tubby-related protein 1
TULP1	O00294	116	166	115	131	Compositional bias	Note=Poly-Glu
TULP1	O00294	63	116	115	131	Compositional bias	Note=Poly-Glu
TULP1	O00294	116	166	64	116	Alternative sequence	ID=VSP_023031;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TULP1	O00294	63	116	64	116	Alternative sequence	ID=VSP_023031;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TULP1	O00294	63	116	67	67	Natural variant	ID=VAR_008274;Note=T->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9096357,ECO:0000269|PubMed:9462751;Dbxref=dbSNP:rs7764472,PMID:9096357,PMID:9462751
TULP1	O00294	116	166	120	127	Natural variant	ID=VAR_013310;Note=In RP14. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9660588;Dbxref=PMID:9660588
TVP23A	A6NH52	194	214	1	213	Chain	ID=PRO_0000327940;Note=Golgi apparatus membrane protein TVP23 homolog A
TVP23A	A6NH52	151	194	1	213	Chain	ID=PRO_0000327940;Note=Golgi apparatus membrane protein TVP23 homolog A
TVP23A	A6NH52	151	194	150	170	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UAP1	Q16222	390	452	1	522	Chain	ID=PRO_0000185767;Note=UDP-N-acetylhexosamine pyrophosphorylase
UAP1	Q16222	453	469	1	522	Chain	ID=PRO_0000185767;Note=UDP-N-acetylhexosamine pyrophosphorylase
UAP1	Q16222	390	452	1	522	Chain	ID=PRO_0000185767;Note=UDP-N-acetylhexosamine pyrophosphorylase
UAP1	Q16222	453	469	1	522	Chain	ID=PRO_0000185767;Note=UDP-N-acetylhexosamine pyrophosphorylase
UAP1	Q16222	390	452	407	407	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11707391;Dbxref=PMID:11707391
UAP1	Q16222	390	452	407	407	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11707391;Dbxref=PMID:11707391
UAP1	Q16222	453	469	454	470	Alternative sequence	ID=VSP_004483;Note=In isoform AGX1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8025165,ECO:0000303|PubMed:9603950;Dbxref=PMID:14702039,PMID:15489334,PMID:8025165,PMID:9603950
UAP1	Q16222	453	469	454	470	Alternative sequence	ID=VSP_004483;Note=In isoform AGX1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8025165,ECO:0000303|PubMed:9603950;Dbxref=PMID:14702039,PMID:15489334,PMID:8025165,PMID:9603950
UAP1	Q16222	453	469	454	454	Alternative sequence	ID=VSP_014523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8025165;Dbxref=PMID:8025165
UAP1	Q16222	453	469	454	454	Alternative sequence	ID=VSP_014523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8025165;Dbxref=PMID:8025165
UAP1	Q16222	390	452	418	418	Natural variant	ID=VAR_014935;Note=P->H;Dbxref=dbSNP:rs1128539
UAP1	Q16222	390	452	418	418	Natural variant	ID=VAR_014935;Note=P->H;Dbxref=dbSNP:rs1128539
UAP1	Q16222	390	452	445	445	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	390	452	445	445	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	390	452	445	445	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	390	452	445	445	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	453	469	454	454	Sequence conflict	Note=S->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	453	469	454	454	Sequence conflict	Note=S->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	453	469	454	454	Sequence conflict	Note=S->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	453	469	454	454	Sequence conflict	Note=S->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
UAP1	Q16222	390	452	390	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	390	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	399	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	399	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	412	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	412	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	418	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	418	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	439	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UAP1	Q16222	390	452	439	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JV1
UBA1	P22314	473	525	2	1058	Chain	ID=PRO_0000194934;Note=Ubiquitin-like modifier-activating enzyme 1
UBA1	P22314	882	946	2	1058	Chain	ID=PRO_0000194934;Note=Ubiquitin-like modifier-activating enzyme 1
UBA1	P22314	473	525	2	1058	Chain	ID=PRO_0000194934;Note=Ubiquitin-like modifier-activating enzyme 1
UBA1	P22314	882	946	2	1058	Chain	ID=PRO_0000194934;Note=Ubiquitin-like modifier-activating enzyme 1
UBA1	P22314	473	525	459	611	Repeat	Note=1-2
UBA1	P22314	473	525	459	611	Repeat	Note=1-2
UBA1	P22314	473	525	63	611	Region	Note=2 approximate repeats
UBA1	P22314	473	525	63	611	Region	Note=2 approximate repeats
UBA1	P22314	473	525	478	478	Binding site	Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22515
UBA1	P22314	473	525	478	478	Binding site	Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22515
UBA1	P22314	473	525	504	504	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22515
UBA1	P22314	473	525	504	504	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22515
UBA1	P22314	473	525	515	515	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22515
UBA1	P22314	473	525	515	515	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22515
TSPAN32	Q96QS1	93	118	1	320	Chain	ID=PRO_0000219278;Note=Tetraspanin-32
TSPAN32	Q96QS1	181	209	1	320	Chain	ID=PRO_0000219278;Note=Tetraspanin-32
TSPAN32	Q96QS1	93	118	90	110	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN32	Q96QS1	181	209	203	223	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN32	Q96QS1	181	209	155	320	Alternative sequence	ID=VSP_003934;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10950922;Dbxref=PMID:10950922
TTC16	Q8NEE8	94	142	1	873	Chain	ID=PRO_0000106403;Note=Tetratricopeptide repeat protein 16
TTC16	Q8NEE8	94	142	61	94	Repeat	Note=TPR 1
TTC16	Q8NEE8	94	142	96	128	Repeat	Note=TPR 2
TTC16	Q8NEE8	94	142	136	169	Repeat	Note=TPR 3
TTC16	Q8NEE8	94	142	1	176	Alternative sequence	ID=VSP_056854;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC7B	Q86TV6	655	702	1	843	Chain	ID=PRO_0000106387;Note=Tetratricopeptide repeat protein 7B
TTC7B	Q86TV6	584	622	1	843	Chain	ID=PRO_0000106387;Note=Tetratricopeptide repeat protein 7B
TTC7B	Q86TV6	655	702	696	729	Repeat	Note=TPR 8
TTC7B	Q86TV6	655	702	673	673	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
TTC7B	Q86TV6	655	702	677	677	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TTC7B	Q86TV6	655	702	678	678	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
TTC7B	Q86TV6	655	702	681	681	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TTC7B	Q86TV6	655	702	656	656	Alternative sequence	ID=VSP_008061;Note=In isoform 2. G->GNSPEAYFHGFPSLFSVS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TTC7B	Q86TV6	584	622	583	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DSE
TTC7B	Q86TV6	584	622	599	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DSE
TTC7B	Q86TV6	655	702	692	709	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DSE
TTC12	Q9H892	148	168	1	705	Chain	ID=PRO_0000106395;Note=Tetratricopeptide repeat protein 12
TTC12	Q9H892	436	482	1	705	Chain	ID=PRO_0000106395;Note=Tetratricopeptide repeat protein 12
TTC12	Q9H892	515	538	1	705	Chain	ID=PRO_0000106395;Note=Tetratricopeptide repeat protein 12
TTC12	Q9H892	148	168	140	173	Repeat	Note=TPR 2
TTC12	Q9H892	436	482	468	468	Natural variant	ID=VAR_031432;Note=M->L;Dbxref=dbSNP:rs35852218
SNRNP200	O75643	1870	1918	1	2136	Chain	ID=PRO_0000102087;Note=U5 small nuclear ribonucleoprotein 200 kDa helicase
SNRNP200	O75643	1388	1464	1	2136	Chain	ID=PRO_0000102087;Note=U5 small nuclear ribonucleoprotein 200 kDa helicase
SNRNP200	O75643	1388	1464	1337	1512	Domain	Note=Helicase ATP-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SNRNP200	O75643	1870	1918	1812	2124	Domain	Note=SEC63 2
SNRNP200	O75643	1388	1464	1454	1457	Motif	Note=DEVH box
SNRNP200	O75643	1388	1464	1428	1428	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SNRNP200	O75643	1870	1918	561	2071	Alternative sequence	ID=VSP_026622;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRNP200	O75643	1388	1464	561	2071	Alternative sequence	ID=VSP_026622;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRNP200	O75643	1388	1464	1383	1397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1398	1400	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1405	1407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1412	1421	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1423	1427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1429	1436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1437	1441	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1443	1446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1449	1453	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1456	1460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1388	1464	1464	1479	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F92
SNRNP200	O75643	1870	1918	1865	1874	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q0Z
SNRNP200	O75643	1870	1918	1875	1877	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q0Z
SNRNP200	O75643	1870	1918	1887	1899	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q0Z
SNRNP200	O75643	1870	1918	1906	1932	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q0Z
UBE2D4	Q9Y2X8	40	66	1	147	Chain	ID=PRO_0000270202;Note=Ubiquitin-conjugating enzyme E2 D4
UBE2M	P61081	68	81	1	183	Chain	ID=PRO_0000082488;Note=NEDD8-conjugating enzyme Ubc12
UBE2M	P61081	68	81	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8X
UBE2M	P61081	68	81	70	73	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8X
UBE2M	P61081	68	81	76	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8X
UBE4A	Q14139	766	804	1	1066	Chain	ID=PRO_0000194990;Note=Ubiquitin conjugation factor E4 A
C5orf63	A6NC05	38	57	1	138	Chain	ID=PRO_0000328756;Note=Glutaredoxin-like protein C5orf63
C5orf63	A6NC05	38	57	1	138	Chain	ID=PRO_0000328756;Note=Glutaredoxin-like protein C5orf63
C5orf63	A6NC05	38	57	41	44	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000250;evidence=ECO:0000250
C5orf63	A6NC05	38	57	41	44	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000250;evidence=ECO:0000250
YBX2	Q9Y2T7	123	153	1	364	Chain	ID=PRO_0000100225;Note=Y-box-binding protein 2
YBX2	Q9Y2T7	123	153	93	163	Domain	Note=CSD
YBX2	Q9Y2T7	123	153	87	169	Region	Note=Required for cytoplasmic retention;Ontology_term=ECO:0000250;evidence=ECO:0000250
YBX3	P16989	191	260	2	372	Chain	ID=PRO_0000100214;Note=Y-box-binding protein 3
YBX3	P16989	191	260	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
YBX3	P16989	191	260	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
YBX3	P16989	191	260	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
YBX3	P16989	191	260	251	251	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
YBX3	P16989	191	260	192	260	Alternative sequence	ID=VSP_001135;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRPT1	Q86TN4	186	223	1	253	Chain	ID=PRO_0000273363;Note=tRNA 2'-phosphotransferase 1
TRPT1	Q86TN4	186	223	187	224	Alternative sequence	ID=VSP_045273;Note=In isoform 3. DGIPFFRSANGVILTPGNTDGFLLPKYFKEALQLRPTR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRPT1	Q86TN4	186	223	221	221	Natural variant	ID=VAR_030136;Note=R->C;Dbxref=dbSNP:rs11549690
TRNAU1AP	Q9NX07	137	176	1	287	Chain	ID=PRO_0000304917;Note=tRNA selenocysteine 1-associated protein 1
TRNAU1AP	Q9NX07	137	176	96	175	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
TRNAU1AP	Q9NX07	137	176	136	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRNAU1AP	Q9NX07	137	176	147	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRNAU1AP	Q9NX07	137	176	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRNAU1AP	Q9NX07	137	176	162	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TSPAN1	O60635	19	88	1	241	Chain	ID=PRO_0000219234;Note=Tetraspanin-1
TSPAN1	O60635	88	113	1	241	Chain	ID=PRO_0000219234;Note=Tetraspanin-1
TSPAN1	O60635	113	146	1	241	Chain	ID=PRO_0000219234;Note=Tetraspanin-1
TSPAN1	O60635	146	198	1	241	Chain	ID=PRO_0000219234;Note=Tetraspanin-1
TSPAN1	O60635	19	88	12	32	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	19	88	33	52	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	19	88	53	73	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	19	88	74	88	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	88	113	74	88	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	88	113	89	109	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	88	113	110	211	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	113	146	110	211	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	146	198	110	211	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN1	O60635	113	146	141	141	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	154	154	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	178	178	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	184	184	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	19	88	38	38	Natural variant	ID=VAR_052327;Note=S->F;Dbxref=dbSNP:rs2234267
TSPAN1	O60635	19	88	87	87	Natural variant	ID=VAR_034573;Note=V->M;Dbxref=dbSNP:rs2234268
TSPAN1	O60635	113	146	141	141	Mutagenesis	Note=Loss of glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	154	154	Mutagenesis	Note=Loss of glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	178	178	Mutagenesis	Note=Loss of glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	184	184	Mutagenesis	Note=Loss of glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19508227;Dbxref=PMID:19508227
TSPAN1	O60635	146	198	189	189	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSNARE1	Q96NA8	29	79	1	513	Chain	ID=PRO_0000065668;Note=t-SNARE domain-containing protein 1
TSNARE1	Q96NA8	29	79	55	55	Natural variant	ID=VAR_051461;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs33970858,PMID:14702039
TSKS	Q9UJT2	331	395	1	592	Chain	ID=PRO_0000065665;Note=Testis-specific serine kinase substrate
TSKS	Q9UJT2	331	395	382	382	Natural variant	ID=VAR_051460;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15044604;Dbxref=dbSNP:rs2304202,PMID:15044604
TSPAN13	O95857	104	142	1	204	Chain	ID=PRO_0000219258;Note=Tetraspanin-13
TSPAN13	O95857	142	180	1	204	Chain	ID=PRO_0000219258;Note=Tetraspanin-13
TSPAN13	O95857	104	142	94	167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN13	O95857	142	180	94	167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN13	O95857	142	180	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN13	O95857	142	180	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D8C2
TSPAN13	O95857	104	142	113	113	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN13	O95857	104	142	137	137	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTC22	Q5TAA0	340	391	1	569	Chain	ID=PRO_0000263098;Note=Tetratricopeptide repeat protein 22
TTC22	Q5TAA0	286	340	1	569	Chain	ID=PRO_0000263098;Note=Tetratricopeptide repeat protein 22
TTC22	Q5TAA0	286	340	260	294	Repeat	Note=TPR 4
TTC22	Q5TAA0	286	340	295	328	Repeat	Note=TPR 5
TTC22	Q5TAA0	340	391	383	418	Repeat	Note=TPR 6
TTC22	Q5TAA0	340	391	341	372	Alternative sequence	ID=VSP_021859;Note=In isoform 2. IHIRAYLHDLKRAKMGLGGMPDRNHLACAKAD->RRGLTMLPRLVSNSWAQAVLPPRPPKVLEFQV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC22	Q5TAA0	340	391	373	569	Alternative sequence	ID=VSP_021860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC22	Q5TAA0	286	340	324	324	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTC24	A2A3L6	485	523	1	582	Chain	ID=PRO_0000307771;Note=Tetratricopeptide repeat protein 24
TTC24	A2A3L6	485	523	1	582	Chain	ID=PRO_0000307771;Note=Tetratricopeptide repeat protein 24
TTLL10	Q6ZVT0	39	66	1	673	Chain	ID=PRO_0000324520;Note=Inactive polyglycylase TTLL10
TTLL10	Q6ZVT0	39	66	1	673	Chain	ID=PRO_0000324520;Note=Inactive polyglycylase TTLL10
TTLL10	Q6ZVT0	39	66	1	73	Alternative sequence	ID=VSP_032262;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TTLL10	Q6ZVT0	39	66	1	73	Alternative sequence	ID=VSP_032262;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TTC29	Q8NA56	195	266	1	475	Chain	ID=PRO_0000294435;Note=Tetratricopeptide repeat protein 29
TTC29	Q8NA56	195	266	182	215	Repeat	Note=TPR 1
TTC29	Q8NA56	195	266	234	267	Repeat	Note=TPR 2
TTC29	Q8NA56	195	266	239	239	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTC33	Q6PID6	101	145	1	262	Chain	ID=PRO_0000287515;Note=Tetratricopeptide repeat protein 33
TTC33	Q6PID6	101	145	93	126	Repeat	Note=TPR 2
TTC33	Q6PID6	101	145	127	160	Repeat	Note=TPR 3
TULP2	O00295	392	425	1	520	Chain	ID=PRO_0000186468;Note=Tubby-related protein 2
TULP2	O00295	212	316	1	520	Chain	ID=PRO_0000186468;Note=Tubby-related protein 2
TULP2	O00295	70	116	1	520	Chain	ID=PRO_0000186468;Note=Tubby-related protein 2
TULP2	O00295	212	316	245	245	Natural variant	ID=VAR_022136;Note=E->K;Dbxref=dbSNP:rs2270945
TULP2	O00295	212	316	251	251	Natural variant	ID=VAR_024679;Note=D->N;Dbxref=dbSNP:rs8112811
TTBK1	Q5TCY1	157	192	1	1321	Chain	ID=PRO_0000234341;Note=Tau-tubulin kinase 1
TTBK1	Q5TCY1	157	192	34	297	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TTBK1	Q5TCY1	157	192	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NFN
TTBK1	Q5TCY1	157	192	160	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NFN
TTBK1	Q5TCY1	157	192	166	170	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NFN
TTBK1	Q5TCY1	157	192	172	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NFN
TTBK1	Q5TCY1	157	192	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTM
TTYH2	Q9BSA4	310	341	1	534	Chain	ID=PRO_0000312246;Note=Protein tweety homolog 2
TTYH2	Q9BSA4	341	372	1	534	Chain	ID=PRO_0000312246;Note=Protein tweety homolog 2
TTYH2	Q9BSA4	420	481	1	534	Chain	ID=PRO_0000312246;Note=Protein tweety homolog 2
TTYH2	Q9BSA4	310	341	262	388	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH2	Q9BSA4	341	372	262	388	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH2	Q9BSA4	420	481	410	534	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH2	Q9BSA4	420	481	423	431	Compositional bias	Note=Poly-Asp
TTYH2	Q9BSA4	310	341	1	321	Alternative sequence	ID=VSP_040567;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTYH2	Q9BSA4	420	481	423	423	Natural variant	ID=VAR_037465;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs9899862,PMID:14702039,PMID:15489334
TUFT1	Q9NNX1	45	79	1	390	Chain	ID=PRO_0000183186;Note=Tuftelin
TUFT1	Q9NNX1	108	138	1	390	Chain	ID=PRO_0000183186;Note=Tuftelin
TUFT1	Q9NNX1	160	198	1	390	Chain	ID=PRO_0000183186;Note=Tuftelin
TUFT1	Q9NNX1	108	138	88	126	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TUFT1	Q9NNX1	160	198	162	351	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TUFT1	Q9NNX1	45	79	21	79	Alternative sequence	ID=VSP_006686;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11733143;Dbxref=PMID:11733143
TUFT1	Q9NNX1	45	79	21	45	Alternative sequence	ID=VSP_006685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11733143,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11733143,PMID:14702039,PMID:15489334
TXNDC8	Q6A555	43	63	1	127	Chain	ID=PRO_0000120162;Note=Thioredoxin domain-containing protein 8
TXNDC8	Q6A555	43	63	1	92	Domain	Note=Thioredoxin
TXNDC8	Q6A555	43	63	60	60	Natural variant	ID=VAR_057353;Note=N->H;Dbxref=dbSNP:rs7041938
TEX264	Q9Y6I9	86	160	33	313	Chain	ID=PRO_0000022601;Note=Testis-expressed protein 264
TEX264	Q9Y6I9	86	160	33	313	Chain	ID=PRO_0000022601;Note=Testis-expressed protein 264
TEX264	Q9Y6I9	86	160	33	313	Chain	ID=PRO_0000022601;Note=Testis-expressed protein 264
TEX264	Q9Y6I9	86	160	33	313	Chain	ID=PRO_0000022601;Note=Testis-expressed protein 264
TEX264	Q9Y6I9	86	160	33	313	Chain	ID=PRO_0000022601;Note=Testis-expressed protein 264
TYRP1	P17643	420	469	25	537	Chain	ID=PRO_0000035889;Note=5%2C6-dihydroxyindole-2-carboxylic acid oxidase
TYRP1	P17643	420	469	25	477	Topological domain	Note=Lumenal%2C melanosome;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYRP1	P17643	420	469	418	420	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M8S
TYRP1	P17643	420	469	422	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M8L
TYRP1	P17643	420	469	427	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M8S
TYRP1	P17643	420	469	449	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M8S
TYRP1	P17643	420	469	456	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M8S
TYRP1	P17643	420	469	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M8S
TRRAP	Q9Y4A5	50	87	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	1491	1509	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	2070	2107	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	2227	2269	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	2269	2318	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	2497	2557	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	2871	2935	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	3201	3256	2	3859	Chain	ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein
TRRAP	Q9Y4A5	2871	2935	2704	3275	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
TRRAP	Q9Y4A5	3201	3256	2704	3275	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
TRRAP	Q9Y4A5	2070	2107	2010	2388	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177
TRRAP	Q9Y4A5	2227	2269	2010	2388	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177
TRRAP	Q9Y4A5	2269	2318	2010	2388	Region	Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177
TRRAP	Q9Y4A5	2070	2107	2077	2077	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TRRAP	Q9Y4A5	2497	2557	2543	2543	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TRRAP	Q9Y4A5	1491	1509	1492	1509	Alternative sequence	ID=VSP_009102;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9708738;Dbxref=PMID:9708738
TRRAP	Q9Y4A5	2269	2318	2302	2302	Natural variant	ID=VAR_041666;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs528967912,PMID:17344846
TRRAP	Q9Y4A5	2871	2935	2931	2931	Natural variant	ID=VAR_041671;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
TSPAN4	O14817	21	85	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	110	144	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	21	85	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	110	144	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	21	85	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	110	144	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	21	85	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	110	144	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	21	85	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	110	144	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	21	85	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	110	144	1	238	Chain	ID=PRO_0000219241;Note=Tetraspanin-4
TSPAN4	O14817	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	35	55	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	77	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	110	144	107	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	110	144	107	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	110	144	107	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	110	144	107	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	110	144	107	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	110	144	107	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN4	O14817	21	85	67	67	Natural variant	ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TSPAN4	O14817	21	85	67	67	Natural variant	ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TSPAN4	O14817	21	85	67	67	Natural variant	ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TSPAN4	O14817	21	85	67	67	Natural variant	ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TSPAN4	O14817	21	85	67	67	Natural variant	ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TSPAN4	O14817	21	85	67	67	Natural variant	ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TSPAN18	Q96SJ8	21	86	1	248	Chain	ID=PRO_0000219268;Note=Tetraspanin-18
TSPAN18	Q96SJ8	21	86	1	248	Chain	ID=PRO_0000219268;Note=Tetraspanin-18
TSPAN18	Q96SJ8	21	86	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	14	34	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	35	49	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	35	49	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	50	70	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	50	70	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	71	83	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	71	83	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	84	104	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN18	Q96SJ8	21	86	84	104	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSTD2	Q5T7W7	201	243	1	516	Chain	ID=PRO_0000230673;Note=Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
TSTD2	Q5T7W7	201	243	1	260	Alternative sequence	ID=VSP_017825;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
TTC9C	Q8N5M4	79	140	1	171	Chain	ID=PRO_0000294465;Note=Tetratricopeptide repeat protein 9C
TTC9C	Q8N5M4	79	140	1	171	Chain	ID=PRO_0000294465;Note=Tetratricopeptide repeat protein 9C
TTC9C	Q8N5M4	79	140	72	107	Repeat	Note=TPR 2
TTC9C	Q8N5M4	79	140	72	107	Repeat	Note=TPR 2
TTC9C	Q8N5M4	79	140	108	141	Repeat	Note=TPR 3
TTC9C	Q8N5M4	79	140	108	141	Repeat	Note=TPR 3
TTC9C	Q8N5M4	79	140	80	171	Alternative sequence	ID=VSP_056611;Note=In isoform 2. ACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG->VVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TTC9C	Q8N5M4	79	140	80	171	Alternative sequence	ID=VSP_056611;Note=In isoform 2. ACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG->VVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TXNL1	O43396	245	280	2	289	Chain	ID=PRO_0000120016;Note=Thioredoxin-like protein 1
TXNL1	O43396	65	123	2	289	Chain	ID=PRO_0000120016;Note=Thioredoxin-like protein 1
TXNL1	O43396	245	280	2	289	Chain	ID=PRO_0000120016;Note=Thioredoxin-like protein 1
TXNL1	O43396	65	123	2	289	Chain	ID=PRO_0000120016;Note=Thioredoxin-like protein 1
TXNL1	O43396	65	123	2	109	Domain	Note=Thioredoxin
TXNL1	O43396	65	123	2	109	Domain	Note=Thioredoxin
TXNL1	O43396	245	280	115	285	Domain	Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864
TXNL1	O43396	65	123	115	285	Domain	Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864
TXNL1	O43396	245	280	115	285	Domain	Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864
TXNL1	O43396	65	123	115	285	Domain	Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864
TXNL1	O43396	65	123	113	113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TXNL1	O43396	65	123	113	113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TXNL1	O43396	65	123	65	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	65	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	75	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	96	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	65	123	96	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GH2
TXNL1	O43396	245	280	241	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY
TXNL1	O43396	245	280	241	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY
TXNL1	O43396	245	280	263	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY
TXNL1	O43396	245	280	263	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY
RXFP2	Q8WXD0	286	309	1	754	Chain	ID=PRO_0000069702;Note=Relaxin receptor 2
RXFP2	Q8WXD0	286	309	1	416	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP2	Q8WXD0	286	309	282	303	Repeat	Note=LRR 7
RXFP2	Q8WXD0	286	309	306	327	Repeat	Note=LRR 8
RXFP2	Q8WXD0	286	309	286	309	Alternative sequence	ID=VSP_042831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16051677;Dbxref=PMID:16051677
TERT	O14746	885	947	1	1132	Chain	ID=PRO_0000054925;Note=Telomerase reverse transcriptase
TERT	O14746	885	947	605	935	Domain	Note=Reverse transcriptase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00405
TERT	O14746	885	947	914	928	Region	Note=Required for oligomerization
TERT	O14746	885	947	930	934	Region	Note=Primer grip sequence
TERT	O14746	885	947	936	1132	Region	Note=CTE
TERT	O14746	885	947	808	1132	Alternative sequence	ID=VSP_019588;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12869302,ECO:0000303|PubMed:14654914;Dbxref=PMID:12869302,PMID:14654914
TERT	O14746	885	947	885	947	Alternative sequence	ID=VSP_021727;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14654914;Dbxref=PMID:14654914
TERT	O14746	885	947	901	901	Natural variant	ID=VAR_062541;Note=In DKCB4%3B severe phenotype overlapping with Hoyeraal-Hreidarsson syndrome%3B very short telomeres and greatly reduced telomerase activity. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17785587;Dbxref=dbSNP:rs199422304,PMID:17785587
TERT	O14746	885	947	902	902	Natural variant	ID=VAR_036869;Note=In DKCA2%3B abolishes telomerase catalytic activity but no effect on binding to TERC. K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16247010,ECO:0000269|PubMed:16990594;Dbxref=dbSNP:rs121918665,PMID:16247010,PMID:16990594
TERT	O14746	885	947	902	902	Natural variant	ID=VAR_068798;Note=In PFBMFT1. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21436073;Dbxref=dbSNP:rs387907250,PMID:21436073
TERT	O14746	885	947	923	923	Natural variant	ID=VAR_068799;Note=In PFBMFT1. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22512499;Dbxref=dbSNP:rs387907251,PMID:22512499
TERT	O14746	885	947	930	934	Mutagenesis	Note=Completely abolishes telomerase-mediated primer extension and reduced binding to short telomeric primers. Complete loss of catalytic activity but no further loss of binding to telomeric primers%3B when associated with 137-A--A-141. WCGLL->AAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17296728;Dbxref=PMID:17296728
STK11IP	Q8N1F8	146	182	1	1088	Chain	ID=PRO_0000317462;Note=Serine/threonine-protein kinase 11-interacting protein
STK11IP	Q8N1F8	283	315	1	1088	Chain	ID=PRO_0000317462;Note=Serine/threonine-protein kinase 11-interacting protein
STK11IP	Q8N1F8	315	329	1	1088	Chain	ID=PRO_0000317462;Note=Serine/threonine-protein kinase 11-interacting protein
STK11IP	Q8N1F8	603	642	1	1088	Chain	ID=PRO_0000317462;Note=Serine/threonine-protein kinase 11-interacting protein
STK11IP	Q8N1F8	701	778	1	1088	Chain	ID=PRO_0000317462;Note=Serine/threonine-protein kinase 11-interacting protein
STK11IP	Q8N1F8	146	182	132	152	Repeat	Note=LRR 2
STK11IP	Q8N1F8	146	182	164	185	Repeat	Note=LRR 3
STK11IP	Q8N1F8	283	315	280	301	Repeat	Note=LRR 8
STK11IP	Q8N1F8	701	778	761	761	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
STK11IP	Q8N1F8	701	778	773	773	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
STK11IP	Q8N1F8	701	778	777	777	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
STK11IP	Q8N1F8	701	778	741	741	Natural variant	ID=VAR_038532;Note=S->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11572484,ECO:0000269|PubMed:11741830,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs627530,PMID:11572484,PMID:11741830,PMID:15489334
SLC12A3	P55017	522	556	1	1021	Chain	ID=PRO_0000178026;Note=Solute carrier family 12 member 3
SLC12A3	P55017	556	608	1	1021	Chain	ID=PRO_0000178026;Note=Solute carrier family 12 member 3
SLC12A3	P55017	522	556	512	532	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A3	P55017	522	556	535	555	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A3	P55017	522	556	556	577	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A3	P55017	556	608	556	577	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A3	P55017	556	608	578	598	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A3	P55017	522	556	523	523	Natural variant	ID=VAR_075956;Note=In GTLMNS. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22009145;Dbxref=dbSNP:rs781137708,PMID:22009145
SLC12A3	P55017	522	556	534	534	Natural variant	ID=VAR_075957;Note=In GTLMNS. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22009145;Dbxref=dbSNP:rs780433336,PMID:22009145
SLC12A3	P55017	522	556	536	536	Natural variant	ID=VAR_075958;Note=In GTLMNS. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22009145;Dbxref=dbSNP:rs748650798,PMID:22009145
SLC12A3	P55017	522	556	542	542	Natural variant	ID=VAR_039509;Note=In GTLMNS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8900229;Dbxref=dbSNP:rs574357286,PMID:8900229
SLC12A3	P55017	522	556	546	546	Natural variant	ID=VAR_075959;Note=In GTLMNS. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22009145;Dbxref=PMID:22009145
SLC12A3	P55017	522	556	555	555	Natural variant	ID=VAR_039510;Note=In GTLMNS. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11168953,ECO:0000269|PubMed:22009145;Dbxref=dbSNP:rs148038173,PMID:11168953,PMID:22009145
SLC12A3	P55017	556	608	560	560	Natural variant	ID=VAR_039511;Note=In GTLMNS. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9734597;Dbxref=PMID:9734597
SLC12A3	P55017	556	608	560	560	Natural variant	ID=VAR_075960;Note=In GTLMNS. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22009145;Dbxref=PMID:22009145
SLC12A3	P55017	556	608	561	561	Natural variant	ID=VAR_007118;Note=In GTLMNS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8528245;Dbxref=PMID:8528245
SLC12A3	P55017	556	608	566	566	Natural variant	ID=VAR_075961;Note=In GTLMNS%3B associated with T-192. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22009145;Dbxref=PMID:22009145
SLC12A3	P55017	556	608	569	569	Natural variant	ID=VAR_039512;Note=In GTLMNS. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10616841;Dbxref=PMID:10616841
SLC12A3	P55017	556	608	569	569	Natural variant	ID=VAR_039513;Note=In GTLMNS. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15069170;Dbxref=dbSNP:rs79351185,PMID:15069170
SLC12A3	P55017	556	608	578	578	Natural variant	ID=VAR_039514;Note=In GTLMNS. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10616841;Dbxref=dbSNP:rs139329616,PMID:10616841
SLC12A3	P55017	556	608	588	588	Natural variant	ID=VAR_007119;Note=In GTLMNS. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8528245,ECO:0000269|PubMed:8900229;Dbxref=dbSNP:rs121909382,PMID:8528245,PMID:8900229
SLC12A3	P55017	522	556	539	539	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TESK2	Q96S53	264	293	1	571	Chain	ID=PRO_0000086749;Note=Dual specificity testis-specific protein kinase 2
TESK2	Q96S53	236	264	1	571	Chain	ID=PRO_0000086749;Note=Dual specificity testis-specific protein kinase 2
TESK2	Q96S53	131	180	1	571	Chain	ID=PRO_0000086749;Note=Dual specificity testis-specific protein kinase 2
TESK2	Q96S53	264	293	58	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TESK2	Q96S53	236	264	58	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TESK2	Q96S53	131	180	58	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TESK2	Q96S53	131	180	176	176	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
TESK2	Q96S53	131	180	116	131	Alternative sequence	ID=VSP_004930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10512679;Dbxref=PMID:10512679
TESK2	Q96S53	264	293	265	293	Alternative sequence	ID=VSP_004931;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC23A2	Q9UGH3	69	108	1	650	Chain	ID=PRO_0000165978;Note=Solute carrier family 23 member 2
SLC23A2	Q9UGH3	36	69	1	650	Chain	ID=PRO_0000165978;Note=Solute carrier family 23 member 2
SLC23A2	Q9UGH3	69	108	1	650	Chain	ID=PRO_0000165978;Note=Solute carrier family 23 member 2
SLC23A2	Q9UGH3	36	69	1	650	Chain	ID=PRO_0000165978;Note=Solute carrier family 23 member 2
SLC23A2	Q9UGH3	69	108	9	110	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A2	Q9UGH3	36	69	9	110	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A2	Q9UGH3	69	108	9	110	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A2	Q9UGH3	36	69	9	110	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A2	Q9UGH3	69	108	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EPR4
SLC23A2	Q9UGH3	69	108	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EPR4
SLC23A2	Q9UGH3	69	108	75	75	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTW8
SLC23A2	Q9UGH3	69	108	75	75	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTW8
SLC23A2	Q9UGH3	69	108	78	78	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EPR4
SLC23A2	Q9UGH3	69	108	78	78	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EPR4
SLC23A2	Q9UGH3	69	108	79	79	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EPR4
SLC23A2	Q9UGH3	69	108	79	79	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EPR4
SLC23A2	Q9UGH3	69	108	81	81	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
SLC23A2	Q9UGH3	69	108	81	81	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
SLC22A9	Q8IVM8	466	533	1	553	Chain	ID=PRO_0000233715;Note=Solute carrier family 22 member 9
SLC22A9	Q8IVM8	466	533	458	469	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A9	Q8IVM8	466	533	470	490	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A9	Q8IVM8	466	533	491	495	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A9	Q8IVM8	466	533	496	516	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A9	Q8IVM8	466	533	517	553	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A9	Q8IVM8	466	533	347	553	Alternative sequence	ID=VSP_036711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC22A9	Q8IVM8	466	533	487	487	Natural variant	ID=VAR_036404;Note=In a breast cancer sample%3B somatic mutation. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SLC22A9	Q8IVM8	466	533	521	521	Natural variant	ID=VAR_036405;Note=In a colorectal cancer sample%3B somatic mutation. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs770073076,PMID:16959974
SLC22A9	Q8IVM8	466	533	518	518	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC22A11	Q9NSA0	461	529	1	550	Chain	ID=PRO_0000234435;Note=Solute carrier family 22 member 11
SLC22A11	Q9NSA0	461	529	452	463	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A11	Q9NSA0	461	529	464	484	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A11	Q9NSA0	461	529	485	490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A11	Q9NSA0	461	529	491	511	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A11	Q9NSA0	461	529	512	550	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A11	Q9NSA0	461	529	353	461	Alternative sequence	ID=VSP_018319;Note=In isoform 2. NFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVR->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC22A11	Q9NSA0	461	529	469	469	Mutagenesis	Note=Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport%3B when associated with A-47%3B A-52%3B A-83 and A-305. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15291761;Dbxref=PMID:15291761
SLC25A39	Q9BZJ4	294	321	1	359	Chain	ID=PRO_0000090596;Note=Solute carrier family 25 member 39
SLC25A39	Q9BZJ4	172	230	1	359	Chain	ID=PRO_0000090596;Note=Solute carrier family 25 member 39
SLC25A39	Q9BZJ4	48	63	1	359	Chain	ID=PRO_0000090596;Note=Solute carrier family 25 member 39
SLC25A39	Q9BZJ4	172	230	161	181	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A39	Q9BZJ4	172	230	215	235	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A39	Q9BZJ4	294	321	318	338	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A39	Q9BZJ4	48	63	9	151	Repeat	Note=Solcar 1
SLC25A39	Q9BZJ4	172	230	159	243	Repeat	Note=Solcar 2
SLC25A39	Q9BZJ4	294	321	253	347	Repeat	Note=Solcar 3
SLC25A36	Q96CQ1	14	68	1	311	Chain	ID=PRO_0000291797;Note=Solute carrier family 25 member 36
SLC25A36	Q96CQ1	69	94	1	311	Chain	ID=PRO_0000291797;Note=Solute carrier family 25 member 36
SLC25A36	Q96CQ1	14	68	7	27	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A36	Q96CQ1	14	68	41	57	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A36	Q96CQ1	14	68	4	108	Repeat	Note=Solcar 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00282
SLC25A36	Q96CQ1	69	94	4	108	Repeat	Note=Solcar 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00282
SLC25A36	Q96CQ1	14	68	1	157	Alternative sequence	ID=VSP_035517;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC25A36	Q96CQ1	69	94	1	157	Alternative sequence	ID=VSP_035517;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC23A1	Q9UHI7	484	516	1	598	Chain	ID=PRO_0000165975;Note=Solute carrier family 23 member 1
SLC23A1	Q9UHI7	488	520	1	598	Chain	ID=PRO_0000165975;Note=Solute carrier family 23 member 1
SLC23A1	Q9UHI7	484	516	479	490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A1	Q9UHI7	488	520	479	490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A1	Q9UHI7	484	516	491	511	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A1	Q9UHI7	488	520	491	511	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A1	Q9UHI7	484	516	512	598	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A1	Q9UHI7	488	520	512	598	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A48	Q6ZT89	86	172	1	311	Chain	ID=PRO_0000325768;Note=Solute carrier family 25 member 48
SLC25A48	Q6ZT89	86	172	107	127	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A48	Q6ZT89	86	172	3	86	Repeat	Note=Solcar 1
SLC25A48	Q6ZT89	86	172	101	205	Repeat	Note=Solcar 2
SLC25A48	Q6ZT89	86	172	141	157	Alternative sequence	ID=VSP_032397;Note=In isoform 3. ANLGLKSRAVAPAEQPA->GGEHRMTTVFPGPHLCM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A48	Q6ZT89	86	172	158	311	Alternative sequence	ID=VSP_032398;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC28A1	O00337	239	265	1	649	Chain	ID=PRO_0000070446;Note=Sodium/nucleoside cotransporter 1
SLC28A1	O00337	239	265	1	649	Chain	ID=PRO_0000070446;Note=Sodium/nucleoside cotransporter 1
SLC28A1	O00337	239	265	223	261	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A1	O00337	239	265	223	261	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A1	O00337	239	265	262	283	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A1	O00337	239	265	262	283	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A1	O00337	239	265	176	649	Alternative sequence	ID=VSP_037222;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC28A1	O00337	239	265	176	649	Alternative sequence	ID=VSP_037222;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC28A2	O43868	549	582	1	658	Chain	ID=PRO_0000070450;Note=Sodium/nucleoside cotransporter 2
SLC28A2	O43868	549	582	529	549	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A2	O43868	549	582	567	587	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEX2	Q8IWB9	808	857	1	1127	Chain	ID=PRO_0000244479;Note=Testis-expressed protein 2
TEX2	Q8IWB9	808	857	1	1127	Chain	ID=PRO_0000244479;Note=Testis-expressed protein 2
TEX2	Q8IWB9	808	857	816	1101	Domain	Note=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
TEX2	Q8IWB9	808	857	816	1101	Domain	Note=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
TEX2	Q8IWB9	808	857	816	821	Compositional bias	Note=Poly-Glu
TEX2	Q8IWB9	808	857	816	821	Compositional bias	Note=Poly-Glu
TEX2	Q8IWB9	808	857	815	815	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPJ0
TEX2	Q8IWB9	808	857	815	815	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPJ0
TEX2	Q8IWB9	808	857	835	835	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEX2	Q8IWB9	808	857	835	835	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEX30	Q5JUR7	5	82	1	227	Chain	ID=PRO_0000274312;Note=Testis-expressed protein 30
SLC29A1	Q99808	151	196	2	456	Chain	ID=PRO_0000209337;Note=Equilibrative nucleoside transporter 1
SLC29A1	Q99808	151	196	2	456	Chain	ID=PRO_0000209337;Note=Equilibrative nucleoside transporter 1
SLC29A1	Q99808	151	196	2	456	Chain	ID=PRO_0000209337;Note=Equilibrative nucleoside transporter 1
SLC29A1	Q99808	151	196	2	456	Chain	ID=PRO_0000209337;Note=Equilibrative nucleoside transporter 1
SLC29A1	Q99808	151	196	2	456	Chain	ID=PRO_0000209337;Note=Equilibrative nucleoside transporter 1
SLC29A1	Q99808	151	196	2	456	Chain	ID=PRO_0000209337;Note=Equilibrative nucleoside transporter 1
SLC29A1	Q99808	151	196	139	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	139	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	139	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	139	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	139	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	139	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	158	174	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	158	174	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	158	174	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	158	174	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	158	174	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	158	174	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	175	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	175	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	175	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	175	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	175	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A1	Q99808	151	196	175	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	1	456	Chain	ID=PRO_0000209340;Note=Equilibrative nucleoside transporter 2
SLC29A2	Q14542	138	183	1	456	Chain	ID=PRO_0000209340;Note=Equilibrative nucleoside transporter 2
SLC29A2	Q14542	138	183	1	456	Chain	ID=PRO_0000209340;Note=Equilibrative nucleoside transporter 2
SLC29A2	Q14542	138	183	124	144	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	124	144	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	124	144	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A2	Q14542	138	183	93	202	Alternative sequence	ID=VSP_040728;Note=In isoform 2. VPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVG->AGQGGHEPRTLLLHHHGLRLLHQLLQCSPTGQPLRAAGHHALHLQHPLPQRPGPGWDLCCPCHAPVHGQWRGRRDLCPGVLYHALCGHPHVHRVLPEPASPEVCPLLPGQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7639753;Dbxref=PMID:7639753
SLC29A2	Q14542	138	183	93	202	Alternative sequence	ID=VSP_040728;Note=In isoform 2. VPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVG->AGQGGHEPRTLLLHHHGLRLLHQLLQCSPTGQPLRAAGHHALHLQHPLPQRPGPGWDLCCPCHAPVHGQWRGRRDLCPGVLYHALCGHPHVHRVLPEPASPEVCPLLPGQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7639753;Dbxref=PMID:7639753
SLC29A2	Q14542	138	183	93	202	Alternative sequence	ID=VSP_040728;Note=In isoform 2. VPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVG->AGQGGHEPRTLLLHHHGLRLLHQLLQCSPTGQPLRAAGHHALHLQHPLPQRPGPGWDLCCPCHAPVHGQWRGRRDLCPGVLYHALCGHPHVHRVLPEPASPEVCPLLPGQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7639753;Dbxref=PMID:7639753
SLC29A4	Q7RTT9	100	138	1	530	Chain	ID=PRO_0000326251;Note=Equilibrative nucleoside transporter 4
SLC29A4	Q7RTT9	181	206	1	530	Chain	ID=PRO_0000326251;Note=Equilibrative nucleoside transporter 4
SLC29A4	Q7RTT9	100	138	1	530	Chain	ID=PRO_0000326251;Note=Equilibrative nucleoside transporter 4
SLC29A4	Q7RTT9	181	206	1	530	Chain	ID=PRO_0000326251;Note=Equilibrative nucleoside transporter 4
SLC29A4	Q7RTT9	100	138	90	101	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	100	138	90	101	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	100	138	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	100	138	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	100	138	123	139	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	100	138	123	139	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	181	206	167	187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	181	206	167	187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	181	206	188	231	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	181	206	188	231	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC29A4	Q7RTT9	181	206	139	182	Alternative sequence	ID=VSP_032647;Note=In isoform 2. GYLLALGPLLFISICDVWLQLFSRDQAYAINLAAVGTVAFGCTV->ASATCGCSSSLGTRPTPSTWPLWAPWPSAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC29A4	Q7RTT9	181	206	139	182	Alternative sequence	ID=VSP_032647;Note=In isoform 2. GYLLALGPLLFISICDVWLQLFSRDQAYAINLAAVGTVAFGCTV->ASATCGCSSSLGTRPTPSTWPLWAPWPSAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC29A4	Q7RTT9	100	138	124	124	Natural variant	ID=VAR_040045;Note=N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855675,PMID:15489334
SLC29A4	Q7RTT9	100	138	124	124	Natural variant	ID=VAR_040045;Note=N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855675,PMID:15489334
SLC29A4	Q7RTT9	100	138	107	107	Mutagenesis	Note=Loss of cationic transport activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17121826;Dbxref=PMID:17121826
SLC29A4	Q7RTT9	100	138	107	107	Mutagenesis	Note=Loss of cationic transport activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17121826;Dbxref=PMID:17121826
SLC29A4	Q7RTT9	100	138	128	128	Mutagenesis	Note=No significant change in cationic transport activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17121826;Dbxref=PMID:17121826
SLC29A4	Q7RTT9	100	138	128	128	Mutagenesis	Note=No significant change in cationic transport activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17121826;Dbxref=PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=Loss of cationic transport activity. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=Loss of cationic transport activity. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=No loss of cationic transporter activity%3B no activity towards uridine. E->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=No loss of cationic transporter activity%3B no activity towards uridine. E->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=Loss of cationic transporter activity%3B increase in uridine uptake. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=Loss of cationic transporter activity%3B increase in uridine uptake. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=Loss of cationic transporter activity. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	206	206	Mutagenesis	Note=Loss of cationic transporter activity. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16873718,ECO:0000269|PubMed:17121826;Dbxref=PMID:16873718,PMID:17121826
SLC29A4	Q7RTT9	181	206	196	196	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC29A4	Q7RTT9	181	206	196	196	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC36A4	Q6YBV0	180	256	1	504	Chain	ID=PRO_0000308318;Note=Proton-coupled amino acid transporter 4
SLC36A4	Q6YBV0	180	256	206	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC36A4	Q6YBV0	180	256	231	251	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC36A4	Q6YBV0	180	256	209	209	Natural variant	ID=VAR_036791;Note=L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854446,PMID:15489334
SLC35F3	Q8IY50	313	343	1	421	Chain	ID=PRO_0000307879;Note=Putative thiamine transporter SLC35F3
SLC35F3	Q8IY50	313	343	305	325	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35F3	Q8IY50	313	343	326	346	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35F5	Q8WV83	139	160	1	523	Chain	ID=PRO_0000311956;Note=Solute carrier family 35 member F5
SLC35F5	Q8WV83	91	139	1	523	Chain	ID=PRO_0000311956;Note=Solute carrier family 35 member F5
SLC35F5	Q8WV83	91	139	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A13	Q96H72	179	215	1	371	Chain	ID=PRO_0000312309;Note=Zinc transporter ZIP13
SLC39A13	Q96H72	215	245	1	371	Chain	ID=PRO_0000312309;Note=Zinc transporter ZIP13
SLC39A13	Q96H72	179	215	171	235	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A13	Q96H72	215	245	171	235	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A13	Q96H72	215	245	236	256	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A13	Q96H72	179	215	187	191	Compositional bias	Note=Poly-Ala
SLC45A3	Q96JT2	57	319	1	553	Chain	ID=PRO_0000122519;Note=Solute carrier family 45 member 3
SLC45A3	Q96JT2	57	319	52	72	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC45A3	Q96JT2	57	319	88	108	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC45A3	Q96JT2	57	319	120	140	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC45A3	Q96JT2	57	319	161	181	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC45A3	Q96JT2	57	319	198	218	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC45A3	Q96JT2	57	319	275	295	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC36A2	Q495M3	248	281	1	483	Chain	ID=PRO_0000324819;Note=Proton-coupled amino acid transporter 2
SLC36A2	Q495M3	248	281	244	264	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC36A2	Q495M3	248	281	265	285	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC36A2	Q495M3	248	281	1	276	Alternative sequence	ID=VSP_032371;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC36A2	Q495M3	248	281	277	281	Alternative sequence	ID=VSP_032373;Note=In isoform 3. ESIGV->MNDTA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC38A8	A6NNN8	177	210	1	435	Chain	ID=PRO_0000319593;Note=Putative sodium-coupled neutral amino acid transporter 8
SLC38A8	A6NNN8	177	210	178	198	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A6	Q9Y2P4	160	228	1	619	Chain	ID=PRO_0000193216;Note=Long-chain fatty acid transport protein 6
SLC27A6	Q9Y2P4	160	228	1	619	Chain	ID=PRO_0000193216;Note=Long-chain fatty acid transport protein 6
SLC27A6	Q9Y2P4	160	228	1	619	Chain	ID=PRO_0000193216;Note=Long-chain fatty acid transport protein 6
SLC27A6	Q9Y2P4	160	228	221	232	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A6	Q9Y2P4	160	228	221	232	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A6	Q9Y2P4	160	228	221	232	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A6	Q9Y2P4	160	228	207	207	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC27A6	Q9Y2P4	160	228	207	207	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC27A6	Q9Y2P4	160	228	207	207	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC27A6	Q9Y2P4	160	228	215	215	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC27A6	Q9Y2P4	160	228	215	215	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC27A6	Q9Y2P4	160	228	215	215	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCF7L1	Q9HCS4	147	175	1	588	Chain	ID=PRO_0000048614;Note=Transcription factor 7-like 1
TCF7L1	Q9HCS4	383	419	1	588	Chain	ID=PRO_0000048614;Note=Transcription factor 7-like 1
TCF7L1	Q9HCS4	383	419	346	414	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
TCF7L1	Q9HCS4	147	175	117	326	Compositional bias	Note=Pro-rich
TCF7L1	Q9HCS4	147	175	147	147	Natural variant	ID=VAR_035938;Note=In a breast cancer sample%3B somatic mutation. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TFAM	Q00059	147	179	43	246	Chain	ID=PRO_0000013470;Note=Transcription factor A%2C mitochondrial
TFAM	Q00059	147	179	155	219	DNA binding	Note=HMG box 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
TFAM	Q00059	147	179	160	160	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23201127;Dbxref=PMID:23201127
TFAM	Q00059	147	179	148	179	Alternative sequence	ID=VSP_047019;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFAM	Q00059	147	179	178	178	Natural variant	ID=VAR_077842;Note=In MTDPS15. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27448789;Dbxref=dbSNP:rs757075712,PMID:27448789
TFAM	Q00059	147	179	162	162	Mutagenesis	Note=Moderate reduction in DNA bending. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22037171;Dbxref=PMID:22037171
TFAM	Q00059	147	179	123	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TQ6
TFAM	Q00059	147	179	161	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FGH
TFAM	Q00059	147	179	175	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FGH
TFAM	Q00059	147	179	178	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FGH
SAMM50	Q9Y512	216	259	1	469	Chain	ID=PRO_0000215939;Note=Sorting and assembly machinery component 50 homolog
SAMM50	Q9Y512	259	283	1	469	Chain	ID=PRO_0000215939;Note=Sorting and assembly machinery component 50 homolog
SAMM50	Q9Y512	216	259	255	255	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TFPI	P10646	209	269	29	304	Chain	ID=PRO_0000016871;Note=Tissue factor pathway inhibitor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2452157;Dbxref=PMID:2452157
TFPI	P10646	106	119	29	304	Chain	ID=PRO_0000016871;Note=Tissue factor pathway inhibitor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2452157;Dbxref=PMID:2452157
TFPI	P10646	209	269	29	304	Chain	ID=PRO_0000016871;Note=Tissue factor pathway inhibitor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2452157;Dbxref=PMID:2452157
TFPI	P10646	106	119	29	304	Chain	ID=PRO_0000016871;Note=Tissue factor pathway inhibitor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2452157;Dbxref=PMID:2452157
TFPI	P10646	209	269	217	267	Domain	Note=BPTI/Kunitz inhibitor 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI	P10646	209	269	217	267	Domain	Note=BPTI/Kunitz inhibitor 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI	P10646	209	269	227	228	Site	Note=Reactive bond
TFPI	P10646	209	269	227	228	Site	Note=Reactive bond
TFPI	P10646	209	269	256	256	Site	Note=Not glycosylated
TFPI	P10646	209	269	256	256	Site	Note=Not glycosylated
TFPI	P10646	209	269	217	267	Disulfide bond	.
TFPI	P10646	209	269	217	267	Disulfide bond	.
TFPI	P10646	209	269	226	250	Disulfide bond	.
TFPI	P10646	209	269	226	250	Disulfide bond	.
TFPI	P10646	209	269	242	263	Disulfide bond	.
TFPI	P10646	209	269	242	263	Disulfide bond	.
TFPI	P10646	209	269	210	251	Alternative sequence	ID=VSP_003030;Note=In isoform Beta. EFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCG->VTKEGTNDGWKNAAHIYQVFLNAFCIHASMFFLGLDSISCLC;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
TFPI	P10646	209	269	210	251	Alternative sequence	ID=VSP_003030;Note=In isoform Beta. EFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCG->VTKEGTNDGWKNAAHIYQVFLNAFCIHASMFFLGLDSISCLC;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
TFPI	P10646	209	269	252	304	Alternative sequence	ID=VSP_003031;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
TFPI	P10646	209	269	252	304	Alternative sequence	ID=VSP_003031;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
TFPI	P10646	209	269	227	227	Mutagenesis	Note=Abolishes inhibition of VII(a)/TF. R->L
TFPI	P10646	209	269	227	227	Mutagenesis	Note=Abolishes inhibition of VII(a)/TF. R->L
TFPI	P10646	106	119	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ADZ
TFPI	P10646	106	119	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ADZ
TFPI	P10646	209	269	215	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	215	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	224	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	224	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	241	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	241	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	257	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	257	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	261	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI	P10646	209	269	261	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IRH
TFPI2	P48307	153	210	23	235	Chain	ID=PRO_0000016876;Note=Tissue factor pathway inhibitor 2
TFPI2	P48307	90	153	23	235	Chain	ID=PRO_0000016876;Note=Tissue factor pathway inhibitor 2
TFPI2	P48307	90	153	96	149	Domain	Note=BPTI/Kunitz inhibitor 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	153	210	158	208	Domain	Note=BPTI/Kunitz inhibitor 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	90	153	107	108	Site	Note=Reactive bond;Ontology_term=ECO:0000250;evidence=ECO:0000250
TFPI2	P48307	153	210	168	169	Site	Note=Reactive bond;Ontology_term=ECO:0000250;evidence=ECO:0000250
TFPI2	P48307	90	153	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFPI2	P48307	153	210	170	170	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFPI2	P48307	90	153	96	149	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	90	153	106	130	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	90	153	122	145	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	153	210	158	208	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	153	210	167	191	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	153	210	183	204	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
TFPI2	P48307	90	153	102	102	Natural variant	ID=VAR_012005;Note=V->A;Dbxref=dbSNP:rs1804202
SART3	Q15020	400	436	2	963	Chain	ID=PRO_0000223313;Note=Squamous cell carcinoma antigen recognized by T-cells 3
SART3	Q15020	302	354	2	963	Chain	ID=PRO_0000223313;Note=Squamous cell carcinoma antigen recognized by T-cells 3
SART3	Q15020	302	354	324	356	Repeat	Note=HAT 5
SART3	Q15020	400	436	394	430	Repeat	Note=HAT 7
SART3	Q15020	302	354	2	351	Region	Note=Mediates interaction with PRPF3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15314151;Dbxref=PMID:15314151
SART3	Q15020	400	436	130	963	Alternative sequence	ID=VSP_017249;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SART3	Q15020	302	354	130	963	Alternative sequence	ID=VSP_017249;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SART3	Q15020	302	354	351	364	Alternative sequence	ID=VSP_017250;Note=In isoform 2. SQYLDRQLKVKDLV->RSTTESKGFGFICT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11959860;Dbxref=PMID:11959860
SART3	Q15020	400	436	365	963	Alternative sequence	ID=VSP_017251;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11959860;Dbxref=PMID:11959860
SART3	Q15020	400	436	401	436	Alternative sequence	ID=VSP_057284;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SART3	Q15020	302	354	279	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJX
SART3	Q15020	302	354	310	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJX
SART3	Q15020	302	354	326	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJX
SART3	Q15020	302	354	344	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJX
SART3	Q15020	400	436	396	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CTQ
SART3	Q15020	400	436	414	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CTQ
SART3	Q15020	400	436	436	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJW
SASH1	O94885	95	112	1	1247	Chain	ID=PRO_0000097597;Note=SAM and SH3 domain-containing protein 1
SASH1	O94885	142	171	1	1247	Chain	ID=PRO_0000097597;Note=SAM and SH3 domain-containing protein 1
SASH1	O94885	209	243	1	1247	Chain	ID=PRO_0000097597;Note=SAM and SH3 domain-containing protein 1
TFR2	Q9UP52	589	665	1	801	Chain	ID=PRO_0000174136;Note=Transferrin receptor protein 2
TFR2	Q9UP52	423	463	1	801	Chain	ID=PRO_0000174136;Note=Transferrin receptor protein 2
TFR2	Q9UP52	283	322	1	801	Chain	ID=PRO_0000174136;Note=Transferrin receptor protein 2
TFR2	Q9UP52	589	665	1	801	Chain	ID=PRO_0000174136;Note=Transferrin receptor protein 2
TFR2	Q9UP52	423	463	1	801	Chain	ID=PRO_0000174136;Note=Transferrin receptor protein 2
TFR2	Q9UP52	283	322	1	801	Chain	ID=PRO_0000174136;Note=Transferrin receptor protein 2
TFR2	Q9UP52	589	665	105	801	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFR2	Q9UP52	423	463	105	801	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFR2	Q9UP52	283	322	105	801	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFR2	Q9UP52	589	665	105	801	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFR2	Q9UP52	423	463	105	801	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFR2	Q9UP52	283	322	105	801	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFR2	Q9UP52	423	463	455	455	Natural variant	ID=VAR_042516;Note=Hereditary hemochromatosis modifier. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12150153;Dbxref=dbSNP:rs41303501,PMID:12150153
TFR2	Q9UP52	423	463	455	455	Natural variant	ID=VAR_042516;Note=Hereditary hemochromatosis modifier. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12150153;Dbxref=dbSNP:rs41303501,PMID:12150153
SELENBP1	Q13228	348	379	2	472	Chain	ID=PRO_0000174633;Note=Methanethiol oxidase
SELENBP1	Q13228	160	221	2	472	Chain	ID=PRO_0000174633;Note=Methanethiol oxidase
SELENBP1	Q13228	58	120	2	472	Chain	ID=PRO_0000174633;Note=Methanethiol oxidase
SELENBP1	Q13228	58	120	111	111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SELENBP1	Q13228	348	379	371	371	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SELENBP1	Q13228	58	120	1	64	Alternative sequence	ID=VSP_038440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SELENBP1	Q13228	58	120	59	120	Alternative sequence	ID=VSP_045425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SELENBP1	Q13228	348	379	347	472	Natural variant	ID=VAR_080209;Note=Probable disease-associated mutation found in a family with extraoral halitosis%3B loss of methanethiol oxidation in patient cells. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29255262;Dbxref=PMID:29255262
SELENBP1	Q13228	58	120	80	80	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SELENBP1	Q13228	58	120	92	92	Sequence conflict	Note=T->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SELENBP1	Q13228	58	120	114	116	Sequence conflict	Note=RAP->GPQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SECISBP2L	Q93073	417	473	1	1101	Chain	ID=PRO_0000050739;Note=Selenocysteine insertion sequence-binding protein 2-like
SECISBP2L	Q93073	345	390	1	1101	Chain	ID=PRO_0000050739;Note=Selenocysteine insertion sequence-binding protein 2-like
SECISBP2L	Q93073	345	390	346	390	Alternative sequence	ID=VSP_016342;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9039502;Dbxref=PMID:9039502
SLC5A2	P31639	191	218	1	672	Chain	ID=PRO_0000105372;Note=Sodium/glucose cotransporter 2
SLC5A2	P31639	191	218	189	205	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A2	P31639	191	218	206	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A5	Q92911	233	279	1	643	Chain	ID=PRO_0000105383;Note=Sodium/iodide cotransporter
SLC5A5	Q92911	233	279	208	241	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A5	Q92911	233	279	242	262	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A5	Q92911	233	279	263	286	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A5	Q92911	233	279	267	267	Natural variant	ID=VAR_010265;Note=In TDH1. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9486973;Dbxref=dbSNP:rs121909176,PMID:9486973
SEC24C	P53992	536	599	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	631	670	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	670	727	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	954	1018	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	536	599	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	631	670	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	670	727	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	954	1018	1	1094	Chain	ID=PRO_0000205156;Note=Protein transport protein Sec24C
SEC24C	P53992	954	1018	962	1034	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC24C	P53992	954	1018	962	1034	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC24C	P53992	536	599	1	752	Alternative sequence	ID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC24C	P53992	631	670	1	752	Alternative sequence	ID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC24C	P53992	670	727	1	752	Alternative sequence	ID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC24C	P53992	536	599	1	752	Alternative sequence	ID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC24C	P53992	631	670	1	752	Alternative sequence	ID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC24C	P53992	670	727	1	752	Alternative sequence	ID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC24C	P53992	536	599	546	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	546	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	569	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	569	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	576	578	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	576	578	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	587	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	587	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	591	594	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	591	594	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	595	609	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	536	599	595	609	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	620	632	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	620	632	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	637	643	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	637	643	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	649	651	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	649	651	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	661	663	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	661	663	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	669	672	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	669	672	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	631	670	669	672	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	669	672	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	679	689	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	679	689	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	692	698	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	692	698	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	706	709	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	706	709	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	711	715	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	711	715	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	720	722	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	670	727	720	722	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	980	984	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	980	984	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	986	993	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	986	993	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	999	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	999	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	1011	1013	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24C	P53992	954	1018	1011	1013	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
SEC24D	O94855	608	665	1	1032	Chain	ID=PRO_0000205157;Note=Protein transport protein Sec24D
SEC24D	O94855	569	608	1	1032	Chain	ID=PRO_0000205157;Note=Protein transport protein Sec24D
SEC24D	O94855	132	224	1	1032	Chain	ID=PRO_0000205157;Note=Protein transport protein Sec24D
SEC24D	O94855	132	224	10	293	Compositional bias	Note=Pro-rich
SEC24D	O94855	132	224	224	224	Alternative sequence	ID=VSP_035761;Note=In isoform 2. Q->QA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24D	O94855	132	224	193	193	Natural variant	ID=VAR_047473;Note=P->L;Dbxref=dbSNP:rs6844109
SEC24D	O94855	569	608	558	571	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	569	608	575	581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	569	608	587	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	607	611	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	569	608	607	611	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	614	616	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	617	627	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	630	636	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	644	647	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	649	653	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC24D	O94855	608	665	658	660	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SLC6A9	P48067	585	642	1	706	Chain	ID=PRO_0000214780;Note=Sodium- and chloride-dependent glycine transporter 1
SLC6A9	P48067	29	83	1	706	Chain	ID=PRO_0000214780;Note=Sodium- and chloride-dependent glycine transporter 1
SLC6A9	P48067	29	83	1	108	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A9	P48067	585	642	570	590	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A9	P48067	585	642	610	630	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A9	P48067	585	642	631	706	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A9	P48067	29	83	1	83	Alternative sequence	ID=VSP_006270;Note=In isoform GlyT-1A. MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQ->MVGKGAKGML;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8183239;Dbxref=PMID:8183239
SLC6A9	P48067	29	83	29	82	Alternative sequence	ID=VSP_006271;Note=In isoform GlyT-1B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8183239;Dbxref=PMID:8183239
SLC6A2	P23975	91	135	1	617	Chain	ID=PRO_0000214748;Note=Sodium-dependent noradrenaline transporter
SLC6A2	P23975	261	306	1	617	Chain	ID=PRO_0000214748;Note=Sodium-dependent noradrenaline transporter
SLC6A2	P23975	530	586	1	617	Chain	ID=PRO_0000214748;Note=Sodium-dependent noradrenaline transporter
SLC6A2	P23975	91	135	1	617	Chain	ID=PRO_0000214748;Note=Sodium-dependent noradrenaline transporter
SLC6A2	P23975	261	306	1	617	Chain	ID=PRO_0000214748;Note=Sodium-dependent noradrenaline transporter
SLC6A2	P23975	530	586	1	617	Chain	ID=PRO_0000214748;Note=Sodium-dependent noradrenaline transporter
SLC6A2	P23975	91	135	89	92	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	91	135	89	92	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	91	135	93	116	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	91	135	93	116	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	91	135	117	135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	91	135	117	135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	261	306	258	282	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	261	306	258	282	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	261	306	283	306	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	261	306	283	306	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	523	545	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	523	545	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	546	548	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	546	548	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	549	569	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	549	569	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	570	617	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	530	586	570	617	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6
SLC6A2	P23975	91	135	1	135	Alternative sequence	ID=VSP_054119;Note=In isoform 3. MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFK->MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC6A2	P23975	91	135	1	135	Alternative sequence	ID=VSP_054119;Note=In isoform 3. MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFK->MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC6A2	P23975	91	135	99	99	Natural variant	ID=VAR_011757;Note=T->I;Dbxref=dbSNP:rs1805065
SLC6A2	P23975	91	135	99	99	Natural variant	ID=VAR_011757;Note=T->I;Dbxref=dbSNP:rs1805065
SLC6A2	P23975	261	306	283	283	Natural variant	ID=VAR_020048;Note=T->R;Dbxref=dbSNP:rs45564432
SLC6A2	P23975	261	306	283	283	Natural variant	ID=VAR_020048;Note=T->R;Dbxref=dbSNP:rs45564432
SLC6A2	P23975	261	306	292	292	Natural variant	ID=VAR_011759;Note=N->T;Dbxref=dbSNP:rs5563
SLC6A2	P23975	261	306	292	292	Natural variant	ID=VAR_011759;Note=N->T;Dbxref=dbSNP:rs5563
SLC6A2	P23975	530	586	548	548	Natural variant	ID=VAR_011766;Note=Y->H;Dbxref=dbSNP:rs5559
SLC6A2	P23975	530	586	548	548	Natural variant	ID=VAR_011766;Note=Y->H;Dbxref=dbSNP:rs5559
SLC6A2	P23975	530	586	549	549	Natural variant	ID=VAR_021861;Note=I->T;Dbxref=dbSNP:rs3743788
SLC6A2	P23975	530	586	549	549	Natural variant	ID=VAR_021861;Note=I->T;Dbxref=dbSNP:rs3743788
SLC6A4	P31645	114	159	1	630	Chain	ID=PRO_0000214757;Note=Sodium-dependent serotonin transporter
SLC6A4	P31645	114	159	1	630	Chain	ID=PRO_0000214757;Note=Sodium-dependent serotonin transporter
SLC6A4	P31645	114	159	113	115	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC6A4	P31645	114	159	113	115	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC6A4	P31645	114	159	116	135	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27049939;Dbxref=PMID:27049939
SLC6A4	P31645	114	159	116	135	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27049939;Dbxref=PMID:27049939
SLC6A4	P31645	114	159	136	160	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC6A4	P31645	114	159	136	160	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC6A4	P31645	114	159	142	142	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21992875;Dbxref=PMID:21992875
SLC6A4	P31645	114	159	142	142	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21992875;Dbxref=PMID:21992875
SLC6A4	P31645	114	159	114	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	114	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	118	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	118	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	129	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	129	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	149	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	149	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	156	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SLC6A4	P31645	114	159	156	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X
SCAF11	Q99590	1302	1375	1	1463	Chain	ID=PRO_0000076314;Note=Protein SCAF11
SCAF11	Q99590	280	1186	1	1463	Chain	ID=PRO_0000076314;Note=Protein SCAF11
SCAF11	Q99590	280	1186	841	985	Compositional bias	Note=Arg-rich
SCAF11	Q99590	280	1186	331	331	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF11	Q99590	280	1186	338	338	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SCAF11	Q99590	280	1186	341	341	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SCAF11	Q99590	280	1186	344	344	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SCAF11	Q99590	280	1186	400	400	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF11	Q99590	280	1186	401	401	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF11	Q99590	280	1186	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF11	Q99590	280	1186	405	405	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
SCAF11	Q99590	280	1186	410	410	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SCAF11	Q99590	280	1186	413	413	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
SCAF11	Q99590	280	1186	533	533	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SCAF11	Q99590	280	1186	588	588	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF11	Q99590	280	1186	608	608	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18220336,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
SCAF11	Q99590	280	1186	614	614	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SCAF11	Q99590	280	1186	680	680	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SCAF11	Q99590	280	1186	687	687	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SCAF11	Q99590	280	1186	694	694	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF11	Q99590	280	1186	723	723	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
SCAF11	Q99590	280	1186	726	726	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
SCAF11	Q99590	280	1186	769	769	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF11	Q99590	280	1186	771	771	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SCAF11	Q99590	280	1186	776	776	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
SCAF11	Q99590	280	1186	796	796	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF11	Q99590	280	1186	798	798	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
SCAF11	Q99590	280	1186	802	802	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
SCAF11	Q99590	280	1186	807	807	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SCAF11	Q99590	280	1186	816	816	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SCAF11	Q99590	280	1186	963	963	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SCAF11	Q99590	280	1186	1122	1122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF11	Q99590	280	1186	1127	1127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SCAF11	Q99590	280	1186	1151	1151	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SCAF11	Q99590	280	1186	1153	1153	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF11	Q99590	280	1186	1169	1169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
SCAF11	Q99590	280	1186	1170	1170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF11	Q99590	280	1186	596	596	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SCAF11	Q99590	280	1186	601	601	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
SCAF11	Q99590	280	1186	610	610	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
SCAF11	Q99590	280	1186	676	676	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
SCAF11	Q99590	280	1186	676	676	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
SCAF11	Q99590	280	1186	1126	1126	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SCAF11	Q99590	280	1186	1178	1178	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
SCAF11	Q99590	280	1186	1	315	Alternative sequence	ID=VSP_037665;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224939;Dbxref=PMID:9224939
SCAF11	Q99590	280	1186	657	657	Natural variant	ID=VAR_059722;Note=F->Y;Dbxref=dbSNP:rs7315731
SCAF11	Q99590	280	1186	584	584	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCAF11	Q99590	280	1186	623	623	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCAMP2	O15127	211	244	1	329	Chain	ID=PRO_0000191254;Note=Secretory carrier-associated membrane protein 2
SCAMP2	O15127	211	244	203	218	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCAMP2	O15127	211	244	219	239	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCAMP2	O15127	211	244	240	262	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCAMP2	O15127	211	244	203	218	Region	Note=Interaction with SLC9A7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15840657;Dbxref=PMID:15840657
SCAMP4	Q969E2	98	131	1	229	Chain	ID=PRO_0000191259;Note=Secretory carrier-associated membrane protein 4
SCAMP4	Q969E2	98	131	105	125	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCAMP4	Q969E2	98	131	99	132	Alternative sequence	ID=VSP_026446;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAU2	Q9Y6X3	359	385	1	613	Chain	ID=PRO_0000254548;Note=MAU2 chromatid cohesion factor homolog
MAU2	Q9Y6X3	359	385	379	412	Repeat	Note=TPR 2
MAU2	Q9Y6X3	359	385	1	424	Alternative sequence	ID=VSP_021223;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAU2	Q9Y6X3	359	385	1	394	Alternative sequence	ID=VSP_021224;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
SCFD2	Q8WU76	614	654	1	684	Chain	ID=PRO_0000206290;Note=Sec1 family domain-containing protein 2
SCFD2	Q8WU76	569	614	1	684	Chain	ID=PRO_0000206290;Note=Sec1 family domain-containing protein 2
SCFD2	Q8WU76	614	654	570	614	Alternative sequence	ID=VSP_010710;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCFD2	Q8WU76	569	614	570	614	Alternative sequence	ID=VSP_010710;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCAP	Q12770	1102	1129	1	1279	Chain	ID=PRO_0000051208;Note=Sterol regulatory element-binding protein cleavage-activating protein
SCAP	Q12770	1102	1129	731	1279	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
SCAP	Q12770	1102	1129	1077	1114	Repeat	Note=WD 4
SCAP	Q12770	1102	1129	1117	1155	Repeat	Note=WD 5
SCAP	Q12770	1102	1129	731	1279	Region	Note=Interaction with SREBF2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC25A23	Q9BV35	301	357	1	468	Chain	ID=PRO_0000317609;Note=Calcium-binding mitochondrial carrier protein SCaMC-3
SLC25A23	Q9BV35	265	301	1	468	Chain	ID=PRO_0000317609;Note=Calcium-binding mitochondrial carrier protein SCaMC-3
SLC25A23	Q9BV35	265	301	264	286	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A23	Q9BV35	265	301	287	300	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A23	Q9BV35	301	357	301	336	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A23	Q9BV35	265	301	301	336	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A23	Q9BV35	301	357	337	356	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A23	Q9BV35	301	357	357	379	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A23	Q9BV35	265	301	183	269	Repeat	Note=Solcar 1
SLC25A23	Q9BV35	301	357	277	362	Repeat	Note=Solcar 2
SLC25A23	Q9BV35	265	301	277	362	Repeat	Note=Solcar 2
SCARB2	Q14108	141	204	1	478	Chain	ID=PRO_0000144155;Note=Lysosome membrane protein 2
SCARB2	Q14108	141	204	28	433	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARB2	Q14108	141	204	155	191	Region	Note=Important for interaction with GBA
SCARB2	Q14108	141	204	93	235	Alternative sequence	ID=VSP_044826;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCARB2	Q14108	141	204	138	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCARB2	Q14108	141	204	153	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCARB2	Q14108	141	204	167	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCARB2	Q14108	141	204	173	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCARB2	Q14108	141	204	183	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCARB2	Q14108	141	204	197	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCARB2	Q14108	141	204	201	204	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q4F
SCUBE3	Q8IX30	317	356	21	993	Chain	ID=PRO_0000250616;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	356	398	21	993	Chain	ID=PRO_0000250616;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	636	690	21	993	Chain	ID=PRO_0000250616;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	800	866	21	993	Chain	ID=PRO_0000250616;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	317	356	277	317	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE3	Q8IX30	317	356	318	356	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE3	Q8IX30	356	398	318	356	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE3	Q8IX30	356	398	357	398	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE3	Q8IX30	800	866	804	916	Domain	Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
SCUBE3	Q8IX30	636	690	685	685	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	317	356	322	332	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	317	356	328	341	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	317	356	343	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	356	398	361	372	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	356	398	368	381	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	356	398	383	397	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	800	866	804	830	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	800	866	857	878	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE3	Q8IX30	800	866	856	856	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEL1L3	Q68CR1	862	889	1	1132	Chain	ID=PRO_0000321894;Note=Protein sel-1 homolog 3
SEL1L3	Q68CR1	739	760	1	1132	Chain	ID=PRO_0000321894;Note=Protein sel-1 homolog 3
SEL1L3	Q68CR1	692	739	1	1132	Chain	ID=PRO_0000321894;Note=Protein sel-1 homolog 3
SEL1L3	Q68CR1	592	652	1	1132	Chain	ID=PRO_0000321894;Note=Protein sel-1 homolog 3
SEL1L3	Q68CR1	592	652	575	609	Repeat	Note=Sel1-like 1
SEL1L3	Q68CR1	592	652	611	647	Repeat	Note=Sel1-like 2
SEL1L3	Q68CR1	692	739	694	730	Repeat	Note=Sel1-like 3
SEL1L3	Q68CR1	739	760	732	767	Repeat	Note=Sel1-like 4
SEL1L3	Q68CR1	692	739	732	767	Repeat	Note=Sel1-like 4
SEL1L3	Q68CR1	862	889	840	877	Repeat	Note=Sel1-like 7
SEL1L3	Q68CR1	592	652	608	608	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
VSNL1	P62760	54	126	2	191	Chain	ID=PRO_0000073763;Note=Visinin-like protein 1
VSNL1	P62760	54	126	2	191	Chain	ID=PRO_0000073763;Note=Visinin-like protein 1
VSNL1	P62760	54	126	2	191	Chain	ID=PRO_0000073763;Note=Visinin-like protein 1
VSNL1	P62760	54	126	23	58	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	23	58	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	23	58	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	60	95	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	60	95	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	60	95	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	96	131	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	96	131	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	96	131	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	73	84	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	73	84	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	73	84	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	109	120	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	109	120	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	109	120	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
VSNL1	P62760	54	126	65	65	Natural variant	ID=VAR_047313;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530085;Dbxref=dbSNP:rs1042674,PMID:8530085
VSNL1	P62760	54	126	65	65	Natural variant	ID=VAR_047313;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530085;Dbxref=dbSNP:rs1042674,PMID:8530085
VSNL1	P62760	54	126	65	65	Natural variant	ID=VAR_047313;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530085;Dbxref=dbSNP:rs1042674,PMID:8530085
VSNL1	P62760	54	126	75	75	Sequence conflict	Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
VSNL1	P62760	54	126	75	75	Sequence conflict	Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
VSNL1	P62760	54	126	75	75	Sequence conflict	Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS39	Q96JC1	571	604	1	886	Chain	ID=PRO_0000065901;Note=Vam6/Vps39-like protein
VPS39	Q96JC1	46	57	1	886	Chain	ID=PRO_0000065901;Note=Vam6/Vps39-like protein
VPS39	Q96JC1	46	57	15	294	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
VPS39	Q96JC1	571	604	573	750	Repeat	Note=CHCR
VPS39	Q96JC1	46	57	47	58	Alternative sequence	ID=VSP_004075;Note=In isoform 2. VPADVASPESGS->G;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9872452,ECO:0000303|Ref.2;Dbxref=PMID:15489334,PMID:17974005,PMID:9872452
VSIG10	Q8N0Z9	406	443	31	540	Chain	ID=PRO_0000345115;Note=V-set and immunoglobulin domain-containing protein 10
VSIG10	Q8N0Z9	221	308	31	540	Chain	ID=PRO_0000345115;Note=V-set and immunoglobulin domain-containing protein 10
VSIG10	Q8N0Z9	120	221	31	540	Chain	ID=PRO_0000345115;Note=V-set and immunoglobulin domain-containing protein 10
VSIG10	Q8N0Z9	406	443	31	413	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	221	308	31	413	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	120	221	31	413	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	406	443	414	434	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	406	443	435	540	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	120	221	123	215	Domain	Note=Ig-like C2-type 2
VSIG10	Q8N0Z9	221	308	223	309	Domain	Note=Ig-like C2-type 3
VSIG10	Q8N0Z9	406	443	421	426	Compositional bias	Note=Poly-Leu
VSIG10	Q8N0Z9	120	221	138	138	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	120	221	171	171	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	120	221	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	120	221	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10	Q8N0Z9	120	221	153	201	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VSIG10	Q8N0Z9	221	308	245	290	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VSIG10	Q8N0Z9	406	443	435	435	Natural variant	ID=VAR_045693;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs7307331,PMID:14702039
VTCN1	Q7Z7D3	148	241	25	282	Chain	ID=PRO_0000339237;Note=V-set domain-containing T-cell activation inhibitor 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	32	148	25	282	Chain	ID=PRO_0000339237;Note=V-set domain-containing T-cell activation inhibitor 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	148	241	25	259	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	32	148	25	259	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	32	148	35	146	Domain	Note=Ig-like V-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	148	241	153	241	Domain	Note=Ig-like V-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	148	241	216	216	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTCN1	Q7Z7D3	32	148	56	130	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VTCN1	Q7Z7D3	148	241	168	225	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VTCN1	Q7Z7D3	32	148	1	95	Alternative sequence	ID=VSP_045423;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
VTCN1	Q7Z7D3	148	241	33	148	Alternative sequence	ID=VSP_052841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16782226;Dbxref=PMID:16782226
VTCN1	Q7Z7D3	32	148	33	148	Alternative sequence	ID=VSP_052841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16782226;Dbxref=PMID:16782226
VTCN1	Q7Z7D3	32	148	33	87	Alternative sequence	ID=VSP_052842;Note=In isoform 3. GRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGK->EVSVWLSAMKGWCRSSKASLSIDLCFLNFRETLHHSHYCRLSWEHWGGWNPELHF;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
VTCN1	Q7Z7D3	148	241	88	282	Alternative sequence	ID=VSP_052843;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
VTCN1	Q7Z7D3	32	148	88	282	Alternative sequence	ID=VSP_052843;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
VTCN1	Q7Z7D3	32	148	54	54	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
VTCN1	Q7Z7D3	32	148	39	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	44	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	52	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	64	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	77	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	115	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	122	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	126	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	148	241	137	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
VTCN1	Q7Z7D3	32	148	137	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GOS
WSB2	Q9NYS7	315	350	1	404	Chain	ID=PRO_0000051460;Note=WD repeat and SOCS box-containing protein 2
WSB2	Q9NYS7	278	314	1	404	Chain	ID=PRO_0000051460;Note=WD repeat and SOCS box-containing protein 2
WSB2	Q9NYS7	142	186	1	404	Chain	ID=PRO_0000051460;Note=WD repeat and SOCS box-containing protein 2
WSB2	Q9NYS7	142	186	144	183	Repeat	Note=WD 3
WSB2	Q9NYS7	315	350	283	322	Repeat	Note=WD 6
WSB2	Q9NYS7	278	314	283	322	Repeat	Note=WD 6
WSB2	Q9NYS7	315	350	325	362	Repeat	Note=WD 7
WSB2	Q9NYS7	142	186	1	210	Alternative sequence	ID=VSP_054576;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
XG	P55808	42	63	22	180	Chain	ID=PRO_0000022693;Note=Glycoprotein Xg
XG	P55808	63	84	22	180	Chain	ID=PRO_0000022693;Note=Glycoprotein Xg
XG	P55808	107	124	22	180	Chain	ID=PRO_0000022693;Note=Glycoprotein Xg
XG	P55808	124	136	22	180	Chain	ID=PRO_0000022693;Note=Glycoprotein Xg
XG	P55808	136	175	22	180	Chain	ID=PRO_0000022693;Note=Glycoprotein Xg
XG	P55808	42	63	22	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	63	84	22	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	107	124	22	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	124	136	22	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	136	175	22	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	136	175	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	136	175	164	180	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
XG	P55808	124	136	125	125	Alternative sequence	ID=VSP_037320;Note=In isoform 3. G->GRGGYRLNSRYGNTYG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XG	P55808	42	63	60	60	Natural variant	ID=VAR_054063;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs5939319,PMID:15489334
XIAP	P98170	366	433	1	497	Chain	ID=PRO_0000122352;Note=E3 ubiquitin-protein ligase XIAP
XIAP	P98170	366	433	1	497	Chain	ID=PRO_0000122352;Note=E3 ubiquitin-protein ligase XIAP
XIAP	P98170	366	433	1	497	Chain	ID=PRO_0000122352;Note=E3 ubiquitin-protein ligase XIAP
XIAP	P98170	366	433	423	423	Natural variant	ID=VAR_022285;Note=Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8654366,ECO:0000269|Ref.3;Dbxref=dbSNP:rs5956583,PMID:8654366
XIAP	P98170	366	433	423	423	Natural variant	ID=VAR_022285;Note=Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8654366,ECO:0000269|Ref.3;Dbxref=dbSNP:rs5956583,PMID:8654366
XIAP	P98170	366	433	423	423	Natural variant	ID=VAR_022285;Note=Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8654366,ECO:0000269|Ref.3;Dbxref=dbSNP:rs5956583,PMID:8654366
XIAP	P98170	366	433	368	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	368	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	368	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	375	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	375	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	375	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	386	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	386	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	386	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	407	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	407	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XIAP	P98170	366	433	407	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNA
XPNPEP2	O43895	163	212	22	649	Chain	ID=PRO_0000026829;Note=Xaa-Pro aminopeptidase 2
XPNPEP2	O43895	580	610	22	649	Chain	ID=PRO_0000026829;Note=Xaa-Pro aminopeptidase 2
XPNPEP3	Q9NQH7	21	60	1	31	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255,ECO:0000305|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	21	60	32	507	Chain	ID=PRO_0000255654;Note=Xaa-Pro aminopeptidase 3
XPNPEP3	Q9NQH7	60	196	32	507	Chain	ID=PRO_0000255654;Note=Xaa-Pro aminopeptidase 3
XPNPEP3	Q9NQH7	264	285	32	507	Chain	ID=PRO_0000255654;Note=Xaa-Pro aminopeptidase 3
XPNPEP3	Q9NQH7	285	323	32	507	Chain	ID=PRO_0000255654;Note=Xaa-Pro aminopeptidase 3
XPNPEP3	Q9NQH7	21	60	54	79	Region	Note=Interaction with TNFRSF1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	60	196	54	79	Region	Note=Interaction with TNFRSF1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	285	323	300	300	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5X49,ECO:0000269|PubMed:28476889;Dbxref=PMID:28476889
XPNPEP3	Q9NQH7	21	60	1	79	Alternative sequence	ID=VSP_021296;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
XPNPEP3	Q9NQH7	60	196	1	79	Alternative sequence	ID=VSP_021296;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
XPNPEP3	Q9NQH7	21	60	1	23	Alternative sequence	ID=VSP_040142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
XPNPEP3	Q9NQH7	264	285	265	288	Alternative sequence	ID=VSP_040143;Note=In isoform 5. AFIETMFTSKAPVEEAFLYAKFEF->KSVLLARHGGSRLYSHHFGRPRLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
XPNPEP3	Q9NQH7	285	323	265	288	Alternative sequence	ID=VSP_040143;Note=In isoform 5. AFIETMFTSKAPVEEAFLYAKFEF->KSVLLARHGGSRLYSHHFGRPRLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
XPNPEP3	Q9NQH7	264	285	265	278	Alternative sequence	ID=VSP_021297;Note=In isoform 3. AFIETMFTSKAPVE->RQGFSVLSRLVSNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XPNPEP3	Q9NQH7	264	285	279	507	Alternative sequence	ID=VSP_021298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XPNPEP3	Q9NQH7	285	323	279	507	Alternative sequence	ID=VSP_021298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XPNPEP3	Q9NQH7	285	323	289	507	Alternative sequence	ID=VSP_040144;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
XPNPEP3	Q9NQH7	21	60	29	30	Mutagenesis	Note=Prevents cleavage of N-terminal transit peptide%3B when associated with A-18%3B A-39-40-A and A-44. RR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	21	60	39	40	Mutagenesis	Note=Prevents cleavage of N-terminal transit peptide%3B when associated with A-18%3B A-29-30-A and A-44. RR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	21	60	44	44	Mutagenesis	Note=Prevents cleavage of N-terminal transit peptide%3B when associated with A-18%3B A-29-30-A and A-39-40-A. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	285	323	314	314	Mutagenesis	Note=Impairs catalytic activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25609706;Dbxref=PMID:25609706
XPNPEP3	Q9NQH7	60	196	62	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	69	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	94	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	119	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	133	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	147	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	158	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	170	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	180	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	185	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	60	196	192	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	264	285	249	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	264	285	275	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	264	285	279	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	285	323	279	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	285	323	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	285	323	303	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	285	323	307	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XPNPEP3	Q9NQH7	285	323	320	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5X49
XRCC3	O43542	64	135	1	346	Chain	ID=PRO_0000122951;Note=DNA repair protein XRCC3
XRCC3	O43542	64	135	1	346	Chain	ID=PRO_0000122951;Note=DNA repair protein XRCC3
XRCC3	O43542	64	135	1	346	Chain	ID=PRO_0000122951;Note=DNA repair protein XRCC3
XRCC3	O43542	64	135	1	346	Chain	ID=PRO_0000122951;Note=DNA repair protein XRCC3
XRCC3	O43542	64	135	107	114	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
XRCC3	O43542	64	135	107	114	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
XRCC3	O43542	64	135	107	114	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
XRCC3	O43542	64	135	107	114	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
XRCC3	O43542	64	135	94	94	Natural variant	ID=VAR_020405;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3212057
XRCC3	O43542	64	135	94	94	Natural variant	ID=VAR_020405;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3212057
XRCC3	O43542	64	135	94	94	Natural variant	ID=VAR_020405;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3212057
XRCC3	O43542	64	135	94	94	Natural variant	ID=VAR_020405;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3212057
XRCC6	P12956	376	430	2	609	Chain	ID=PRO_0000210179;Note=X-ray repair cross-complementing protein 6
XRCC6	P12956	507	545	2	609	Chain	ID=PRO_0000210179;Note=X-ray repair cross-complementing protein 6
XRCC6	P12956	376	430	2	609	Chain	ID=PRO_0000210179;Note=X-ray repair cross-complementing protein 6
XRCC6	P12956	507	545	2	609	Chain	ID=PRO_0000210179;Note=X-ray repair cross-complementing protein 6
XRCC6	P12956	376	430	2	609	Chain	ID=PRO_0000210179;Note=X-ray repair cross-complementing protein 6
XRCC6	P12956	507	545	2	609	Chain	ID=PRO_0000210179;Note=X-ray repair cross-complementing protein 6
XRCC6	P12956	376	430	261	468	Domain	Note=Ku
XRCC6	P12956	376	430	261	468	Domain	Note=Ku
XRCC6	P12956	376	430	261	468	Domain	Note=Ku
XRCC6	P12956	507	545	520	520	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
XRCC6	P12956	507	545	520	520	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
XRCC6	P12956	507	545	520	520	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
XRCC6	P12956	376	430	378	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	378	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	378	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	394	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	394	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	394	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	403	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	403	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	403	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	409	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	409	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	409	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	430	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	430	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	376	430	430	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	507	545	511	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	507	545	511	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	507	545	511	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	507	545	521	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	507	545	521	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRCC6	P12956	507	545	521	529	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JEY
XRN1	Q8IZH2	1539	1552	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	1467	1505	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	1068	1087	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	834	872	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	531	571	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	449	478	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	449	478	449	459	Alternative sequence	ID=VSP_016692;Note=In isoform 3. DDFLADQAACY->EYVFANAFILK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1539	1552	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1467	1505	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1068	1087	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	834	872	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	531	571	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	449	478	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1539	1552	1540	1552	Alternative sequence	ID=VSP_016695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
XRN1	Q8IZH2	834	872	834	834	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FDPS	P14324	113	160	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	160	187	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	187	228	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	308	353	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	113	160	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	160	187	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	187	228	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	308	353	1	419	Chain	ID=PRO_0000123944;Note=Farnesyl pyrophosphate synthase
FDPS	P14324	160	187	169	169	Metal binding	Note=Magnesium 1
FDPS	P14324	160	187	169	169	Metal binding	Note=Magnesium 1
FDPS	P14324	160	187	169	169	Metal binding	Note=Magnesium 2
FDPS	P14324	160	187	169	169	Metal binding	Note=Magnesium 2
FDPS	P14324	160	187	173	173	Metal binding	Note=Magnesium 1
FDPS	P14324	160	187	173	173	Metal binding	Note=Magnesium 1
FDPS	P14324	160	187	173	173	Metal binding	Note=Magnesium 2
FDPS	P14324	160	187	173	173	Metal binding	Note=Magnesium 2
FDPS	P14324	308	353	309	309	Metal binding	Note=Magnesium 3
FDPS	P14324	308	353	309	309	Metal binding	Note=Magnesium 3
FDPS	P14324	113	160	123	123	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	113	160	123	123	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	113	160	126	126	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	113	160	126	126	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	160	187	162	162	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	160	187	162	162	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	160	187	178	178	Binding site	Note=Dimethylallyl diphosphate
FDPS	P14324	160	187	178	178	Binding site	Note=Dimethylallyl diphosphate
FDPS	P14324	160	187	179	179	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	160	187	179	179	Binding site	Note=Isopentenyl diphosphate
FDPS	P14324	308	353	323	323	Binding site	Note=Dimethylallyl diphosphate
FDPS	P14324	308	353	323	323	Binding site	Note=Dimethylallyl diphosphate
FDPS	P14324	308	353	332	332	Binding site	Note=Dimethylallyl diphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250
FDPS	P14324	308	353	332	332	Binding site	Note=Dimethylallyl diphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250
FDPS	P14324	160	187	164	164	Site	Note=Important for determining product chain length;Ontology_term=ECO:0000250;evidence=ECO:0000250
FDPS	P14324	160	187	164	164	Site	Note=Important for determining product chain length;Ontology_term=ECO:0000250;evidence=ECO:0000250
FDPS	P14324	160	187	165	165	Site	Note=Important for determining product chain length;Ontology_term=ECO:0000250;evidence=ECO:0000250
FDPS	P14324	160	187	165	165	Site	Note=Important for determining product chain length;Ontology_term=ECO:0000250;evidence=ECO:0000250
FDPS	P14324	113	160	123	123	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FDPS	P14324	113	160	123	123	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FDPS	P14324	308	353	353	353	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FDPS	P14324	308	353	353	353	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
FDPS	P14324	160	187	179	179	Natural variant	ID=VAR_075062;Note=In POROK9. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26202976;Dbxref=dbSNP:rs863225241,PMID:26202976
FDPS	P14324	160	187	179	179	Natural variant	ID=VAR_075062;Note=In POROK9. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26202976;Dbxref=dbSNP:rs863225241,PMID:26202976
FDPS	P14324	113	160	141	141	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
FDPS	P14324	113	160	141	141	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
FDPS	P14324	160	187	182	182	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FDPS	P14324	160	187	182	182	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FDPS	P14324	113	160	105	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	105	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	119	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	119	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	125	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	125	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	140	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	140	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	145	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	160	187	145	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	113	160	145	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	160	187	145	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	160	187	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXS
FDPS	P14324	160	187	176	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QXS
FDPS	P14324	160	187	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	160	187	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	194	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	194	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	219	243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	187	228	219	243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	288	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	288	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	318	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	318	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	327	331	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	327	331	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	335	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	335	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	346	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FDPS	P14324	308	353	346	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NUA
FSD1L	Q9BXM9	5	37	1	530	Chain	ID=PRO_0000089405;Note=FSD1-like protein
FSD1L	Q9BXM9	375	459	1	530	Chain	ID=PRO_0000089405;Note=FSD1-like protein
FSD1L	Q9BXM9	375	459	300	506	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
FSD1L	Q9BXM9	5	37	6	37	Alternative sequence	ID=VSP_039645;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11267680,ECO:0000303|PubMed:14702039;Dbxref=PMID:11267680,PMID:14702039
FSD1L	Q9BXM9	375	459	178	530	Alternative sequence	ID=VSP_039647;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11267680;Dbxref=PMID:11267680
FSD2	A1L4K1	422	467	1	749	Chain	ID=PRO_0000317362;Note=Fibronectin type III and SPRY domain-containing protein 2
FSD2	A1L4K1	245	322	1	749	Chain	ID=PRO_0000317362;Note=Fibronectin type III and SPRY domain-containing protein 2
FSD2	A1L4K1	422	467	375	470	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
FSD2	A1L4K1	245	322	205	317	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FSD2	A1L4K1	422	467	423	467	Alternative sequence	ID=VSP_054600;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FRY	Q5TBA9	82	132	1	3013	Chain	ID=PRO_0000281674;Note=Protein furry homolog
FRY	Q5TBA9	193	230	1	3013	Chain	ID=PRO_0000281674;Note=Protein furry homolog
FRY	Q5TBA9	193	230	213	213	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
FSIP1	Q8NA03	297	350	1	581	Chain	ID=PRO_0000314918;Note=Fibrous sheath-interacting protein 1
RPGRIP1L	Q68CZ1	1098	1144	1	1315	Chain	ID=PRO_0000291267;Note=Protein fantom
RPGRIP1L	Q68CZ1	986	1020	1	1315	Chain	ID=PRO_0000291267;Note=Protein fantom
RPGRIP1L	Q68CZ1	986	1020	987	1020	Alternative sequence	ID=VSP_026161;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
RPGRIP1L	Q68CZ1	1098	1144	1099	1144	Alternative sequence	ID=VSP_026162;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
RPGRIP1L	Q68CZ1	986	1020	992	992	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPGRIP1L	Q68CZ1	1098	1144	1143	1143	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FUNDC1	Q8IVP5	87	130	1	155	Chain	ID=PRO_0000271345;Note=FUN14 domain-containing protein 1
FUNDC1	Q8IVP5	87	130	75	95	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FUNDC1	Q8IVP5	87	130	96	133	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FURIN	P09958	280	351	108	794	Chain	ID=PRO_0000027029;Note=Furin
FURIN	P09958	459	518	108	794	Chain	ID=PRO_0000027029;Note=Furin
FURIN	P09958	280	351	108	715	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
FURIN	P09958	459	518	108	715	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
FURIN	P09958	280	351	144	427	Domain	Note=Peptidase S8;Ontology_term=ECO:0000255;evidence=ECO:0000255
FURIN	P09958	459	518	444	576	Domain	Note=P/Homo B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01173
FURIN	P09958	280	351	292	295	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4OMC,ECO:0000244|PDB:4OMD,ECO:0000244|PDB:4RYD,ECO:0000305|PubMed:24666235,ECO:0000305|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	459	518	498	500	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
FURIN	P09958	280	351	301	301	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:4OMC,ECO:0000244|PDB:4OMD,ECO:0000244|PDB:4RYD,ECO:0000269|PubMed:24666235,ECO:0000269|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	280	351	331	331	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:4OMC,ECO:0000244|PDB:4OMD,ECO:0000244|PDB:4RYD,ECO:0000269|PubMed:24666235,ECO:0000269|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	280	351	306	306	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4OMC,ECO:0000244|PDB:4OMD,ECO:0000244|PDB:4RYD,ECO:0000305|PubMed:24666235,ECO:0000305|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	280	351	308	308	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000305,ECO:0000305;evidence=ECO:0000244|PDB:4OMC,ECO:0000244|PDB:4OMD,ECO:0000244|PDB:4RYD,ECO:0000305|PubMed:24666235,ECO:0000305|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	280	351	211	360	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24666235,ECO:0000269|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	280	351	303	333	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24666235,ECO:0000269|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	459	518	450	474	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24666235,ECO:0000269|PubMed:25974265;Dbxref=PMID:24666235,PMID:25974265
FURIN	P09958	280	351	268	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	282	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	288	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	297	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	307	310	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	338	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	280	351	351	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	459	518	464	471	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	459	518	482	496	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	459	518	498	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	459	518	501	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FURIN	P09958	459	518	512	516	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JXG
FXR1	P51114	210	267	2	621	Chain	ID=PRO_0000050106;Note=Fragile X mental retardation syndrome-related protein 1
FXR1	P51114	467	534	2	621	Chain	ID=PRO_0000050106;Note=Fragile X mental retardation syndrome-related protein 1
FXR1	P51114	210	267	222	251	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
FXR1	P51114	467	534	502	510	Compositional bias	Note=Poly-Arg
FXR1	P51114	467	534	483	483	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61584
FXR1	P51114	467	534	485	485	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
FXR1	P51114	467	534	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51116
FXR1	P51114	210	267	233	233	Natural variant	ID=VAR_036050;Note=In a breast cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
FXR1	P51114	210	267	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	227	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	239	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	250	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	257	260	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FOXRED1	Q96CU9	102	139	1	486	Chain	ID=PRO_0000274142;Note=FAD-dependent oxidoreductase domain-containing protein 1
FOXRED1	Q96CU9	210	244	1	486	Chain	ID=PRO_0000274142;Note=FAD-dependent oxidoreductase domain-containing protein 1
FOXRED1	Q96CU9	102	139	1	211	Alternative sequence	ID=VSP_022629;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
FOXRED1	Q96CU9	210	244	1	211	Alternative sequence	ID=VSP_022629;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CPOX	P36551	391	425	111	454	Chain	ID=PRO_0000006029;Note=Oxygen-dependent coproporphyrinogen-III oxidase%2C mitochondrial
CPOX	P36551	233	270	111	454	Chain	ID=PRO_0000006029;Note=Oxygen-dependent coproporphyrinogen-III oxidase%2C mitochondrial
CPOX	P36551	233	270	260	262	Region	Note=Substrate binding
CPOX	P36551	391	425	392	428	Region	Note=Important for dimerization
CPOX	P36551	391	425	411	413	Region	Note=Substrate binding
CPOX	P36551	233	270	258	258	Active site	Note=Proton donor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16176984;Dbxref=PMID:16176984
CPOX	P36551	233	270	244	244	Binding site	Note=Substrate;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPOX	P36551	391	425	404	404	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P36552
CPOX	P36551	391	425	404	404	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P36552
CPOX	P36551	391	425	288	454	Alternative sequence	ID=VSP_057183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPOX	P36551	233	270	249	249	Natural variant	ID=VAR_023446;Note=In HCP. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15896662;Dbxref=PMID:15896662
CPOX	P36551	233	270	249	249	Natural variant	ID=VAR_002155;Note=In HCP. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9298818;Dbxref=PMID:9298818
CPOX	P36551	391	425	404	404	Natural variant	ID=VAR_002162;Note=In HCP%3B harderoporphyria form. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7757079;Dbxref=dbSNP:rs121917868,PMID:7757079
CPOX	P36551	391	425	392	418	Mutagenesis	Note=Loss for dimerization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16176984;Dbxref=PMID:16176984
CPOX	P36551	233	270	247	247	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPOX	P36551	233	270	237	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEX
CPOX	P36551	233	270	256	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEX
CPOX	P36551	391	425	379	399	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEX
CPOX	P36551	391	425	406	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEX
CPOX	P36551	391	425	409	411	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEX
CPOX	P36551	391	425	414	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEX
GAL	P22466	0	27	1	19	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
GAL	P22466	0	27	20	30	Propeptide	ID=PRO_0000010448
GAL	P22466	74	100	65	123	Peptide	ID=PRO_0000010450;Note=Galanin message-associated peptide
GAL	P22466	0	27	16	16	Natural variant	ID=VAR_049121;Note=A->V;Dbxref=dbSNP:rs34725707
GALNS	P34059	141	188	27	522	Chain	ID=PRO_0000033411;Note=N-acetylgalactosamine-6-sulfatase
GALNS	P34059	141	188	27	379	Region	Note=Catalytic domain
GALNS	P34059	141	188	142	142	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
GALNS	P34059	141	188	141	141	Natural variant	ID=VAR_024888;Note=In MPS4A. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=PMID:16287098
GALNS	P34059	141	188	141	141	Natural variant	ID=VAR_007190;Note=In MPS4A%3B severe form. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=dbSNP:rs794727625,PMID:24726177
GALNS	P34059	141	188	145	145	Natural variant	ID=VAR_071580;Note=In MPS4A%3B reduced enzymatic activity. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=dbSNP:rs577334837,PMID:24726177
GALNS	P34059	141	188	150	150	Natural variant	ID=VAR_024889;Note=In MPS4A. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=dbSNP:rs1168278189,PMID:16287098
GALNS	P34059	141	188	151	151	Natural variant	ID=VAR_007191;Note=In MPS4A%3B severe form. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24726177,ECO:0000269|PubMed:7633425,ECO:0000269|PubMed:7668283,ECO:0000269|PubMed:8651279;Dbxref=dbSNP:rs559063128,PMID:24726177,PMID:7633425,PMID:7668283,PMID:8651279
GALNS	P34059	141	188	151	151	Natural variant	ID=VAR_007192;Note=In MPS4A%3B severe form. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8651279;Dbxref=PMID:8651279
GALNS	P34059	141	188	155	155	Natural variant	ID=VAR_024890;Note=In MPS4A. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=PMID:16287098
GALNS	P34059	141	188	155	155	Natural variant	ID=VAR_007193;Note=In MPS4A%3B severe form. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=dbSNP:rs398123438,PMID:24726177
GALNS	P34059	141	188	156	156	Natural variant	ID=VAR_007194;Note=In MPS4A%3B severe form. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9521421;Dbxref=dbSNP:rs1301146300,PMID:9521421
GALNS	P34059	141	188	156	156	Natural variant	ID=VAR_071581;Note=In MPS4A%3B reduced enzymatic activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=PMID:24726177
GALNS	P34059	141	188	156	156	Natural variant	ID=VAR_007195;Note=In MPS4A%3B mild form. F->S
GALNS	P34059	141	188	159	159	Natural variant	ID=VAR_071582;Note=W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=PMID:24726177
GALNS	P34059	141	188	162	162	Natural variant	ID=VAR_024891;Note=In MPS4A. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=dbSNP:rs118204444,PMID:16287098
GALNS	P34059	141	188	164	164	Natural variant	ID=VAR_024892;Note=In MPS4A. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=dbSNP:rs761725425,PMID:16287098
GALNS	P34059	141	188	165	165	Natural variant	ID=VAR_071583;Note=C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=dbSNP:rs768757999,PMID:24726177
GALNS	P34059	141	188	166	166	Natural variant	ID=VAR_007196;Note=In MPS4A%3B severe form. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9375852;Dbxref=PMID:9375852
GALNS	P34059	141	188	166	166	Natural variant	ID=VAR_071584;Note=In MPS4A%3B reduced enzymatic activity. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24726177;Dbxref=PMID:24726177
GALNS	P34059	141	188	167	167	Natural variant	ID=VAR_024893;Note=In MPS4A. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=dbSNP:rs148565559,PMID:16287098
GALNS	P34059	141	188	168	168	Natural variant	ID=VAR_007197;Note=In MPS4A. G->R;Dbxref=dbSNP:rs775732598
GALNS	P34059	141	188	171	171	Natural variant	ID=VAR_024894;Note=In MPS4A. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=PMID:16287098
GALNS	P34059	141	188	178	178	Natural variant	ID=VAR_007198;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16287098;Dbxref=PMID:16287098
GALNS	P34059	141	188	179	179	Natural variant	ID=VAR_007199;Note=In MPS4A%3B severe form. P->H
GALNS	P34059	141	188	179	179	Natural variant	ID=VAR_007200;Note=In MPS4A%3B severe form. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9521421;Dbxref=PMID:9521421
GALNS	P34059	141	188	179	179	Natural variant	ID=VAR_024895;Note=In MPS4A. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16287098,ECO:0000269|PubMed:24726177;Dbxref=PMID:16287098,PMID:24726177
GALNS	P34059	141	188	185	185	Natural variant	ID=VAR_007201;Note=In MPS4A%3B severe form. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9375852;Dbxref=PMID:9375852
GALNS	P34059	141	188	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDI
GALNS	P34059	141	188	151	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDI
GALNS	P34059	141	188	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDI
GALNS	P34059	141	188	172	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDI
GALNS	P34059	141	188	179	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDI
GALNS	P34059	141	188	185	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FDI
GANAB	Q14697	531	579	29	944	Chain	ID=PRO_0000018571;Note=Neutral alpha-glucosidase AB
GANAB	Q14697	531	579	542	542	Active site	Note=Nucleophile;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10929008;Dbxref=PMID:10929008
GANAB	Q14697	531	579	53	944	Alternative sequence	ID=VSP_039977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GANAB	Q14697	531	579	542	542	Mutagenesis	Note=Loss of activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10929008;Dbxref=PMID:10929008
GALNT3	Q14435	508	542	1	633	Chain	ID=PRO_0000059106;Note=Polypeptide N-acetylgalactosaminyltransferase 3
GALNT3	Q14435	397	464	1	633	Chain	ID=PRO_0000059106;Note=Polypeptide N-acetylgalactosaminyltransferase 3
GALNT3	Q14435	508	542	38	633	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT3	Q14435	397	464	38	633	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT3	Q14435	508	542	504	630	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT3	Q14435	397	464	356	418	Region	Note=Catalytic subdomain B
GALNT3	Q14435	397	464	415	415	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT3	Q14435	397	464	418	418	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT3	Q14435	397	464	173	410	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT3	Q14435	397	464	401	482	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT3	Q14435	508	542	517	535	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT3	Q14435	508	542	193	633	Alternative sequence	ID=VSP_011203;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT3	Q14435	397	464	193	633	Alternative sequence	ID=VSP_011203;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GALNT3	Q14435	508	542	162	633	Natural variant	ID=VAR_080832;Note=In HFTC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15133511;Dbxref=PMID:15133511
GALNT3	Q14435	397	464	162	633	Natural variant	ID=VAR_080832;Note=In HFTC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15133511;Dbxref=PMID:15133511
GLIPR2	Q9H4G4	75	101	2	154	Chain	ID=PRO_0000211524;Note=Golgi-associated plant pathogenesis-related protein 1
GLIPR2	Q9H4G4	75	101	14	132	Domain	Note=SCP
GLIPR2	Q9H4G4	75	101	91	98	Region	Note=Interaction with CAV1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11865038;Dbxref=PMID:11865038
GLIPR2	Q9H4G4	75	101	87	90	Sequence conflict	Note=IKNY->VHFM;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLIPR2	Q9H4G4	75	101	101	154	Sequence conflict	Note=TGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVNEGFFEENVLPPKK->IRFFFFNFLLFLSKPLLYFSYF;Ontology_term=ECO:0000305;evidence=ECO:0000305
GLIPR2	Q9H4G4	75	101	76	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VHG
GLIPR2	Q9H4G4	75	101	85	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VHG
GLIPR2	Q9H4G4	75	101	99	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VHG
HERC1	Q15751	4138	4190	1	4861	Chain	ID=PRO_0000328871;Note=Probable E3 ubiquitin-protein ligase HERC1
HERC1	Q15751	3074	3141	1	4861	Chain	ID=PRO_0000328871;Note=Probable E3 ubiquitin-protein ligase HERC1
HERC1	Q15751	407	511	1	4861	Chain	ID=PRO_0000328871;Note=Probable E3 ubiquitin-protein ligase HERC1
HERC1	Q15751	342	407	1	4861	Chain	ID=PRO_0000328871;Note=Probable E3 ubiquitin-protein ligase HERC1
HERC1	Q15751	407	511	371	420	Repeat	Note=RCC1 1
HERC1	Q15751	342	407	371	420	Repeat	Note=RCC1 1
HERC1	Q15751	407	511	421	475	Repeat	Note=RCC1 2
HERC1	Q15751	407	511	476	528	Repeat	Note=RCC1 3
HERC1	Q15751	4138	4190	4101	4151	Repeat	Note=RCC1 10
HERC1	Q15751	4138	4190	4153	4203	Repeat	Note=RCC1 11
HERC1	Q15751	4138	4190	4136	4141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4143	4150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4155	4159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4162	4164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4168	4170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4174	4179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4181	4183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HERC1	Q15751	4138	4190	4188	4193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O2W
HES4	Q9HCC6	36	68	1	221	Chain	ID=PRO_0000127211;Note=Transcription factor HES-4
HES4	Q9HCC6	36	68	34	91	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
HESX1	Q9UBX0	119	153	1	185	Chain	ID=PRO_0000048922;Note=Homeobox expressed in ES cells 1
HESX1	Q9UBX0	119	153	108	167	DNA binding	Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108
HESX1	Q9UBX0	119	153	125	125	Natural variant	ID=VAR_010400;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9620767;Dbxref=dbSNP:rs9878928,PMID:9620767
HESX1	Q9UBX0	119	153	149	149	Natural variant	ID=VAR_063232;Note=In GHDPA%3B unable to repress PROP1-mediated activation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17148560;Dbxref=dbSNP:rs104893742,PMID:17148560
HESX1	Q9UBX0	119	153	117	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K40
HESX1	Q9UBX0	119	153	135	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K40
HESX1	Q9UBX0	119	153	149	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K40
GSTO1	P78417	122	155	2	241	Chain	ID=PRO_0000185884;Note=Glutathione S-transferase omega-1
GSTO1	P78417	122	155	106	230	Domain	Note=GST C-terminal
GSTO1	P78417	122	155	129	129	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GSTO1	P78417	122	155	143	143	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GSTO1	P78417	122	155	148	148	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GSTO1	P78417	122	155	152	152	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GSTO1	P78417	122	155	123	155	Alternative sequence	ID=VSP_045820;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GSTO1	P78417	122	155	140	140	Natural variant	ID=VAR_016811;Note=In allele GSTO1*C%3B no effect on protein stability. A->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12618591,ECO:0000269|PubMed:12928150,ECO:0000269|PubMed:21106529;Dbxref=dbSNP:rs4925,PMID:12618591,PMID:12928150,PMID:21106529
GSTO1	P78417	122	155	155	155	Natural variant	ID=VAR_016813;Note=In allele GSTO1*B%3B decreased protein stability. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12618591,ECO:0000269|PubMed:12928150,ECO:0000269|PubMed:21106529;Dbxref=PMID:12618591,PMID:12928150,PMID:21106529
GSTO1	P78417	122	155	123	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VLN
GSTO1	P78417	122	155	136	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VLN
GSTO2	Q9H4Y5	122	156	1	243	Chain	ID=PRO_0000185888;Note=Glutathione S-transferase omega-2
GSTO2	Q9H4Y5	122	156	106	231	Domain	Note=GST C-terminal
GSTO2	Q9H4Y5	122	156	123	156	Alternative sequence	ID=VSP_042567;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GSTO2	Q9H4Y5	122	156	130	130	Natural variant	ID=VAR_049492;Note=C->Y;Dbxref=dbSNP:rs45582439
GSTO2	Q9H4Y5	122	156	142	142	Natural variant	ID=VAR_016812;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12618591;Dbxref=dbSNP:rs156697,PMID:12618591
GSTO2	Q9H4Y5	122	156	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q18
GSTO2	Q9H4Y5	122	156	123	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q18
GSTO2	Q9H4Y5	122	156	141	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q18
GSTP1	P09211	112	148	2	210	Chain	ID=PRO_0000185900;Note=Glutathione S-transferase P
GSTP1	P09211	112	148	83	204	Domain	Note=GST C-terminal
GSTP1	P09211	112	148	116	116	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19157
GSTP1	P09211	112	148	128	128	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GSTP1	P09211	112	148	114	114	Natural variant	ID=VAR_014500;Note=In allele GSTP1*C. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9092542,ECO:0000269|Ref.9;Dbxref=dbSNP:rs1138272,PMID:9092542
GSTP1	P09211	112	148	112	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J41
GSTP1	P09211	112	148	138	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J41
GSTP1	P09211	112	148	144	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCW
ENPP1	P22413	424	468	1	925	Chain	ID=PRO_0000188564;Note=Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
ENPP1	P22413	424	468	98	925	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENPP1	P22413	424	468	191	591	Region	Note=Phosphodiesterase
ENPP1	P22413	424	468	424	424	Metal binding	Note=Zinc 1%3B via tele nitrogen%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06802
ENPP1	P22413	424	468	431	530	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
ENPP1	P22413	424	468	456	456	Natural variant	ID=VAR_077268;Note=In GACI1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20016754;Dbxref=dbSNP:rs765071179,PMID:20016754
TMPRSS15	P98073	165	177	2	784	Chain	ID=PRO_0000027719;Note=Enteropeptidase non-catalytic heavy chain
TMPRSS15	P98073	165	177	48	1019	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS15	P98073	165	177	54	169	Domain	Note=SEA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
ENTPD7	Q9NQZ7	3	63	1	604	Chain	ID=PRO_0000274419;Note=Ectonucleoside triphosphate diphosphohydrolase 7
ENTPD7	Q9NQZ7	3	63	1	28	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD7	Q9NQZ7	3	63	29	49	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENTPD7	Q9NQZ7	3	63	50	546	Topological domain	Note=Vesicular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ENY2	Q9NPA8	51	76	1	101	Chain	ID=PRO_0000314130;Note=Transcription and mRNA export factor ENY2
ENY2	Q9NPA8	51	76	74	74	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ENY2	Q9NPA8	51	76	42	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DHX
ENY2	Q9NPA8	51	76	59	61	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DHX
ENY2	Q9NPA8	51	76	64	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DHX
EPHA10	Q5JZY3	804	854	34	1008	Chain	ID=PRO_0000042157;Note=Ephrin type-A receptor 10
EPHA10	Q5JZY3	736	804	34	1008	Chain	ID=PRO_0000042157;Note=Ephrin type-A receptor 10
EPHA10	Q5JZY3	804	854	587	1008	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA10	Q5JZY3	736	804	587	1008	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHA10	Q5JZY3	804	854	645	900	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA10	Q5JZY3	736	804	645	900	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHA10	Q5JZY3	804	854	296	1008	Alternative sequence	ID=VSP_015773;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15777695;Dbxref=PMID:15489334,PMID:15777695
EPHA10	Q5JZY3	736	804	296	1008	Alternative sequence	ID=VSP_015773;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15777695;Dbxref=PMID:15489334,PMID:15777695
EPHA10	Q5JZY3	736	804	749	749	Natural variant	ID=VAR_055995;Note=G->E;Dbxref=dbSNP:rs6671088
EPHA10	Q5JZY3	736	804	775	775	Natural variant	ID=VAR_042163;Note=In a breast infiltrating ductal carcinoma sample%3B somatic mutation. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EPHA10	Q5JZY3	804	854	807	807	Natural variant	ID=VAR_055996;Note=R->Q;Dbxref=dbSNP:rs6670599
EPHB1	P54762	268	320	18	984	Chain	ID=PRO_0000016824;Note=Ephrin type-B receptor 1
EPHB1	P54762	586	627	18	984	Chain	ID=PRO_0000016824;Note=Ephrin type-B receptor 1
EPHB1	P54762	710	782	18	984	Chain	ID=PRO_0000016824;Note=Ephrin type-B receptor 1
EPHB1	P54762	782	832	18	984	Chain	ID=PRO_0000016824;Note=Ephrin type-B receptor 1
EPHB1	P54762	897	948	18	984	Chain	ID=PRO_0000016824;Note=Ephrin type-B receptor 1
EPHB1	P54762	268	320	18	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB1	P54762	586	627	564	984	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB1	P54762	710	782	564	984	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB1	P54762	782	832	564	984	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB1	P54762	897	948	564	984	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EPHB1	P54762	586	627	619	882	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB1	P54762	710	782	619	882	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB1	P54762	782	832	619	882	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB1	P54762	897	948	911	975	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
EPHB1	P54762	586	627	625	633	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EPHB1	P54762	268	320	183	319	Compositional bias	Note=Cys-rich
EPHB1	P54762	710	782	744	744	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
EPHB1	P54762	586	627	600	600	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54753
EPHB1	P54762	897	948	928	928	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
EPHB1	P54762	268	320	1	439	Alternative sequence	ID=VSP_056017;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EPHB1	P54762	268	320	243	984	Alternative sequence	ID=VSP_056019;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB1	P54762	586	627	243	984	Alternative sequence	ID=VSP_056019;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB1	P54762	710	782	243	984	Alternative sequence	ID=VSP_056019;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB1	P54762	782	832	243	984	Alternative sequence	ID=VSP_056019;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB1	P54762	897	948	243	984	Alternative sequence	ID=VSP_056019;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
EPHB1	P54762	710	782	719	719	Natural variant	ID=VAR_042168;Note=In a gastric adenocarcinoma sample%3B somatic mutation. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EPHB1	P54762	710	782	743	743	Natural variant	ID=VAR_042169;Note=In a gastric adenocarcinoma sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EPHB1	P54762	897	948	912	912	Natural variant	ID=VAR_042170;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56345346,PMID:17344846
EPHB1	P54762	586	627	594	594	Mutagenesis	Note=Loss of interaction with NCK1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9430661;Dbxref=PMID:9430661
EPHB1	P54762	586	627	600	600	Mutagenesis	Note=Loss of interaction with SHC1 and SRC. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12925710;Dbxref=PMID:12925710
EPHB1	P54762	710	782	778	778	Mutagenesis	Note=Loss of interaction with SHC1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12925710;Dbxref=PMID:12925710
EPHB1	P54762	897	948	928	928	Mutagenesis	Note=Disrupts binding with the GRB10 SH2 domain%2C providing evidence for phosphorylation. Disrupts interaction with GRB7 and ACP1. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12223469,ECO:0000269|PubMed:8798570,ECO:0000269|PubMed:9499402;Dbxref=PMID:12223469,PMID:8798570,PMID:9499402
EPHB1	P54762	268	320	274	274	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	268	320	274	274	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	268	320	274	274	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	268	320	274	274	Sequence conflict	Note=T->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	710	782	752	752	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	782	832	813	813	Sequence conflict	Note=V->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	782	832	813	813	Sequence conflict	Note=V->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	782	832	819	819	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	782	832	819	819	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	897	948	903	903	Sequence conflict	Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
EPHB1	P54762	586	627	616	618	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	586	627	619	627	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	710	782	705	710	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	710	782	711	714	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	710	782	718	737	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	710	782	747	749	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	710	782	750	752	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	710	782	758	760	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	782	832	783	786	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJB
EPHB1	P54762	782	832	788	790	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	782	832	793	798	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	782	832	803	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	782	832	824	827	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	782	832	830	838	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MJA
EPHB1	P54762	897	948	916	921	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EAO
EPHB1	P54762	897	948	922	924	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EAO
EPHB1	P54762	897	948	926	928	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EAO
EPHB1	P54762	897	948	929	935	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EAO
EPHB1	P54762	897	948	940	943	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EAO
EPHB1	P54762	897	948	948	954	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EAO
SLC2A11	Q9BYW1	328	362	1	496	Chain	ID=PRO_0000050380;Note=Solute carrier family 2%2C facilitated glucose transporter member 11
SLC2A11	Q9BYW1	328	362	312	332	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A11	Q9BYW1	328	362	333	338	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A11	Q9BYW1	328	362	339	359	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A11	Q9BYW1	328	362	360	364	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC2A11	Q9BYW1	328	362	246	496	Alternative sequence	ID=VSP_006295;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	146	191	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	633	648	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	736	769	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	769	831	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	831	883	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	908	957	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	146	191	23	652	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	633	648	23	652	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	736	769	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	769	831	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	831	883	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	908	957	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	736	769	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	769	831	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	831	883	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	908	957	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	831	883	845	845	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
ERBB2	P04626	736	769	753	753	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	146	191	182	182	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ERBB2	P04626	146	191	187	187	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255;evidence=ECO:0000244|PDB:1N8Z,ECO:0000244|PDB:1S78,ECO:0000244|PDB:2A91,ECO:0000244|PDB:3N85,ECO:0000255
ERBB2	P04626	146	191	162	192	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:1N8Z,ECO:0000244|PDB:1S78,ECO:0000244|PDB:2A91,ECO:0000244|PDB:3BE1,ECO:0000244|PDB:3H3B,ECO:0000244|PDB:3MZW,ECO:0000244|PDB:3N85,ECO:0000244|PDB:3WLW,ECO:0000244|PDB:3WSQ,ECO:0000244|PDB:4HRL,ECO:0000244|PDB:4HRM
ERBB2	P04626	633	648	626	634	Disulfide bond	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N85
ERBB2	P04626	633	648	630	642	Disulfide bond	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N85
ERBB2	P04626	146	191	1	686	Alternative sequence	ID=VSP_039250;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	633	648	1	686	Alternative sequence	ID=VSP_039250;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	146	191	1	610	Alternative sequence	ID=VSP_039249;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	633	648	633	648	Alternative sequence	ID=VSP_055902;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	769	831	771	883	Alternative sequence	ID=VSP_055903;Note=In isoform 6. AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK->TISNLFSNFAPRGPSACCEPTCWCHSGKGQDSLPREEWGRQRRFCLWGCRGEPRVLDTPGRSCPSAPPSSCLQPSLRQPLLLGPGPTRAGGSTQHLQRDTYGREPRVPGSGRASVNQKAKSAEALMCPQGAGKA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	831	883	771	883	Alternative sequence	ID=VSP_055903;Note=In isoform 6. AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK->TISNLFSNFAPRGPSACCEPTCWCHSGKGQDSLPREEWGRQRRFCLWGCRGEPRVLDTPGRSCPSAPPSSCLQPSLRQPLLLGPGPTRAGGSTQHLQRDTYGREPRVPGSGRASVNQKAKSAEALMCPQGAGKA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	908	957	884	1255	Alternative sequence	ID=VSP_055904;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	736	769	755	755	Natural variant	ID=VAR_055432;Note=In LNCR%3B somatic mutation%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=dbSNP:rs121913469,PMID:15457249
ERBB2	P04626	736	769	768	768	Natural variant	ID=VAR_042097;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56366519,PMID:17344846
ERBB2	P04626	769	831	774	774	Natural variant	ID=VAR_055433;Note=In LNCR%3B somatic mutation%3B unknown pathological significance. M->MAYVM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=PMID:15457249
ERBB2	P04626	769	831	776	776	Natural variant	ID=VAR_042098;Note=In GASC%3B somatic mutation%3B unknown pathological significance. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15457249,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs28933369,PMID:15457249,PMID:17344846
ERBB2	P04626	769	831	779	779	Natural variant	ID=VAR_055434;Note=In LNCR%3B somatic mutation%3B unknown pathological significance. S->SVGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=PMID:15457249
ERBB2	P04626	831	883	857	857	Natural variant	ID=VAR_042099;Note=In OC%3B somatic mutation%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15457249,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs28933370,PMID:15457249,PMID:17344846
ERBB2	P04626	908	957	914	914	Natural variant	ID=VAR_055435;Note=In GLM%3B somatic mutation%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=dbSNP:rs28933368,PMID:15457249
ERBB2	P04626	146	191	147	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A91
ERBB2	P04626	146	191	152	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MY6
ERBB2	P04626	146	191	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H3B
ERBB2	P04626	146	191	169	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MY6
ERBB2	P04626	146	191	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N8Z
ERBB2	P04626	146	191	182	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H3B
ERBB2	P04626	633	648	635	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N85
ERBB2	P04626	736	769	730	739	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	736	769	748	755	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	736	769	761	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	761	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	785	799	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	806	812	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	814	816	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	819	838	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	819	838	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	848	850	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	851	855	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	858	861	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	901	916	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	922	925	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	931	936	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	949	958	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERCC1	P07992	258	281	1	297	Chain	ID=PRO_0000087006;Note=DNA excision repair protein ERCC-1
ERCC1	P07992	234	258	1	297	Chain	ID=PRO_0000087006;Note=DNA excision repair protein ERCC-1
ERCC1	P07992	35	107	1	297	Chain	ID=PRO_0000087006;Note=DNA excision repair protein ERCC-1
ERCC1	P07992	258	281	1	297	Chain	ID=PRO_0000087006;Note=DNA excision repair protein ERCC-1
ERCC1	P07992	234	258	1	297	Chain	ID=PRO_0000087006;Note=DNA excision repair protein ERCC-1
ERCC1	P07992	35	107	1	297	Chain	ID=PRO_0000087006;Note=DNA excision repair protein ERCC-1
ERCC1	P07992	258	281	220	297	Region	Note=HhH2%2C dimerization with ERCC4
ERCC1	P07992	234	258	220	297	Region	Note=HhH2%2C dimerization with ERCC4
ERCC1	P07992	258	281	220	297	Region	Note=HhH2%2C dimerization with ERCC4
ERCC1	P07992	234	258	220	297	Region	Note=HhH2%2C dimerization with ERCC4
ERCC1	P07992	35	107	37	37	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ERCC1	P07992	35	107	37	37	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ERCC1	P07992	234	258	243	243	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ERCC1	P07992	234	258	243	243	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ERCC1	P07992	35	107	36	107	Alternative sequence	ID=VSP_053474;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERCC1	P07992	35	107	36	107	Alternative sequence	ID=VSP_053474;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ERCC1	P07992	258	281	235	258	Alternative sequence	ID=VSP_042727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
ERCC1	P07992	234	258	235	258	Alternative sequence	ID=VSP_042727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
ERCC1	P07992	258	281	235	258	Alternative sequence	ID=VSP_042727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
ERCC1	P07992	234	258	235	258	Alternative sequence	ID=VSP_042727;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
ERCC1	P07992	258	281	266	266	Natural variant	ID=VAR_019167;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3212977
ERCC1	P07992	258	281	266	266	Natural variant	ID=VAR_019167;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3212977
ERCC1	P07992	35	107	53	53	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERCC1	P07992	35	107	53	53	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERCC1	P07992	35	107	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1I
ERCC1	P07992	35	107	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1I
ERCC1	P07992	35	107	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1I
ERCC1	P07992	35	107	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1I
ERCC1	P07992	234	258	242	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z00
ERCC1	P07992	234	258	242	244	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z00
ERCC1	P07992	234	258	247	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	234	258	247	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	260	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	260	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	268	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	268	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	274	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	274	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	280	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC1	P07992	258	281	280	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1J
ERCC8	Q13216	347	374	1	396	Chain	ID=PRO_0000050970;Note=DNA excision repair protein ERCC-8
ERCC8	Q13216	281	347	1	396	Chain	ID=PRO_0000050970;Note=DNA excision repair protein ERCC-8
ERCC8	Q13216	58	91	1	396	Chain	ID=PRO_0000050970;Note=DNA excision repair protein ERCC-8
ERCC8	Q13216	26	57	1	396	Chain	ID=PRO_0000050970;Note=DNA excision repair protein ERCC-8
ERCC8	Q13216	58	91	33	73	Repeat	Note=WD 1
ERCC8	Q13216	26	57	33	73	Repeat	Note=WD 1
ERCC8	Q13216	58	91	88	129	Repeat	Note=WD 2
ERCC8	Q13216	281	347	281	321	Repeat	Note=WD 6
ERCC8	Q13216	347	374	325	363	Repeat	Note=WD 7
ERCC8	Q13216	281	347	325	363	Repeat	Note=WD 7
ERCC8	Q13216	347	374	206	396	Alternative sequence	ID=VSP_013915;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERCC8	Q13216	281	347	206	396	Alternative sequence	ID=VSP_013915;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ERCC8	Q13216	347	374	361	361	Natural variant	ID=VAR_068177;Note=In UVSS2. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19329487;Dbxref=dbSNP:rs281875221,PMID:19329487
ERCC8	Q13216	26	57	15	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	26	57	30	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	26	57	36	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	26	57	46	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	26	57	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	58	91	58	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	58	91	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	58	91	77	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	58	91	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	58	91	86	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	302	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	307	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	315	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	326	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	337	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	347	374	344	347	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	281	347	344	347	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	347	374	348	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
ERCC8	Q13216	347	374	358	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A11
KDELR3	O43731	64	117	1	214	Chain	ID=PRO_0000194158;Note=ER lumen protein-retaining receptor 3
KDELR3	O43731	64	117	62	80	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDELR3	O43731	64	117	81	96	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDELR3	O43731	64	117	97	110	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDELR3	O43731	64	117	111	117	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ETF1	P62495	287	339	2	437	Chain	ID=PRO_0000143138;Note=Eukaryotic peptide chain release factor subunit 1
ETF1	P62495	287	339	278	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	301	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	305	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	318	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KTU
ETF1	P62495	287	339	336	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KTU
ERMP1	Q7Z2K6	371	442	1	904	Chain	ID=PRO_0000259492;Note=Endoplasmic reticulum metallopeptidase 1
ERMP1	Q7Z2K6	340	371	1	904	Chain	ID=PRO_0000259492;Note=Endoplasmic reticulum metallopeptidase 1
ERMP1	Q7Z2K6	291	340	1	904	Chain	ID=PRO_0000259492;Note=Endoplasmic reticulum metallopeptidase 1
ERMP1	Q7Z2K6	371	442	85	399	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERMP1	Q7Z2K6	340	371	85	399	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERMP1	Q7Z2K6	291	340	85	399	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERMP1	Q7Z2K6	371	442	400	420	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERMP1	Q7Z2K6	371	442	421	457	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERMP1	Q7Z2K6	340	371	354	354	Metal binding	Note=Zinc 2%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80561
ERMP1	Q7Z2K6	340	371	353	353	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80561
ESRRA	P11474	108	147	1	423	Chain	ID=PRO_0000053660;Note=Steroid hormone receptor ERR1
ESRRA	P11474	190	247	1	423	Chain	ID=PRO_0000053660;Note=Steroid hormone receptor ERR1
ESRRA	P11474	247	337	1	423	Chain	ID=PRO_0000053660;Note=Steroid hormone receptor ERR1
ESRRA	P11474	108	147	1	423	Chain	ID=PRO_0000053660;Note=Steroid hormone receptor ERR1
ESRRA	P11474	190	247	1	423	Chain	ID=PRO_0000053660;Note=Steroid hormone receptor ERR1
ESRRA	P11474	247	337	1	423	Chain	ID=PRO_0000053660;Note=Steroid hormone receptor ERR1
ESRRA	P11474	190	247	193	421	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESRRA	P11474	247	337	193	421	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESRRA	P11474	190	247	193	421	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESRRA	P11474	247	337	193	421	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
ESRRA	P11474	108	147	76	151	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRA	P11474	108	147	76	151	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRA	P11474	108	147	115	134	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRA	P11474	108	147	115	134	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRA	P11474	108	147	124	124	Site	Note=Required for DNA-dependent dimerization
ESRRA	P11474	108	147	124	124	Site	Note=Required for DNA-dependent dimerization
ESRRA	P11474	108	147	129	129	Modified residue	Note=N6-acetyllysine%3B by PCAF/KAT2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	108	147	129	129	Modified residue	Note=N6-acetyllysine%3B by PCAF/KAT2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	108	147	138	138	Modified residue	Note=N6-acetyllysine%3B by PCAF/KAT2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	108	147	138	138	Modified residue	Note=N6-acetyllysine%3B by PCAF/KAT2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	190	247	191	191	Alternative sequence	ID=VSP_035756;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8621448;Dbxref=PMID:8621448
ESRRA	P11474	190	247	191	191	Alternative sequence	ID=VSP_035756;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8621448;Dbxref=PMID:8621448
ESRRA	P11474	108	147	118	118	Mutagenesis	Note=Binds DNA as a monomer or as a dimer as for wild type. No effect on interaction with PPARGC1A. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16150865;Dbxref=PMID:16150865
ESRRA	P11474	108	147	118	118	Mutagenesis	Note=Binds DNA as a monomer or as a dimer as for wild type. No effect on interaction with PPARGC1A. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16150865;Dbxref=PMID:16150865
ESRRA	P11474	108	147	124	124	Mutagenesis	Note=Binds DNA predominantly as a monomer. Loss of interaction with PPARGC1A. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16150865;Dbxref=PMID:16150865
ESRRA	P11474	108	147	124	124	Mutagenesis	Note=Binds DNA predominantly as a monomer. Loss of interaction with PPARGC1A. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16150865;Dbxref=PMID:16150865
ESRRA	P11474	108	147	129	129	Mutagenesis	Note=Abolishes acetylation by PCAF/KAT2B%3B when associated with R-138%2C R-160 and R-162. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	108	147	129	129	Mutagenesis	Note=Abolishes acetylation by PCAF/KAT2B%3B when associated with R-138%2C R-160 and R-162. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	108	147	138	138	Mutagenesis	Note=Abolishes acetylation by PCAF/KAT2B%3B when associated with R-129%2C R-160 and R-162. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	108	147	138	138	Mutagenesis	Note=Abolishes acetylation by PCAF/KAT2B%3B when associated with R-129%2C R-160 and R-162. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484414;Dbxref=PMID:20484414
ESRRA	P11474	247	337	258	262	Mutagenesis	Note=Almost complete loss of interaction to L2 or to L3 of PPARGC1A. MSVLQ->VSVLE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18441008;Dbxref=PMID:18441008
ESRRA	P11474	247	337	258	262	Mutagenesis	Note=Almost complete loss of interaction to L2 or to L3 of PPARGC1A. MSVLQ->VSVLE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18441008;Dbxref=PMID:18441008
ESRRA	P11474	247	337	259	259	Mutagenesis	Note=Little effect on binding L2 of PPARGC1A. Greatly reduced binding to L3 of PPARGC1A. S->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18441008;Dbxref=PMID:18441008
ESRRA	P11474	247	337	259	259	Mutagenesis	Note=Little effect on binding L2 of PPARGC1A. Greatly reduced binding to L3 of PPARGC1A. S->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18441008;Dbxref=PMID:18441008
ESRRA	P11474	247	337	315	315	Mutagenesis	Note=Almost complete loss of interaction to L2 or to L3 of PPARGC1A. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18441008;Dbxref=PMID:18441008
ESRRA	P11474	247	337	315	315	Mutagenesis	Note=Almost complete loss of interaction to L2 or to L3 of PPARGC1A. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18441008;Dbxref=PMID:18441008
ESRRA	P11474	190	247	195	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	190	247	195	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	190	247	224	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	190	247	224	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	249	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	249	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	254	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	254	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	284	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	284	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	290	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	290	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	294	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	294	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	300	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	300	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	305	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	305	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	318	320	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	318	320	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	323	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRA	P11474	247	337	323	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K6P
ESRRB	O95718	132	171	1	433	Chain	ID=PRO_0000053662;Note=Steroid hormone receptor ERR2
ESRRB	O95718	132	171	1	433	Chain	ID=PRO_0000053662;Note=Steroid hormone receptor ERR2
ESRRB	O95718	132	171	100	186	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRB	O95718	132	171	100	186	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRB	O95718	132	171	139	163	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRB	O95718	132	171	139	163	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
ESRRB	O95718	132	171	93	211	Region	Note=Interaction with NANOG;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61539
ESRRB	O95718	132	171	93	211	Region	Note=Interaction with NANOG;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61539
ESRRB	O95718	132	171	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	149	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	149	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	156	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	156	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
ESRRB	O95718	132	171	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LO1
EXOSC1	Q9Y3B2	115	132	1	195	Chain	ID=PRO_0000087127;Note=Exosome complex component CSL4
EXOSC1	Q9Y3B2	49	74	1	195	Chain	ID=PRO_0000087127;Note=Exosome complex component CSL4
EXOSC1	Q9Y3B2	115	132	66	147	Domain	Note=S1 motif
EXOSC1	Q9Y3B2	49	74	66	147	Domain	Note=S1 motif
EXOSC1	Q9Y3B2	49	74	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC1	Q9Y3B2	49	74	70	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC1	Q9Y3B2	115	132	118	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC1	Q9Y3B2	115	132	124	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
FAM168B	A1KXE4	23	51	1	195	Chain	ID=PRO_0000325978;Note=Myelin-associated neurite-outgrowth inhibitor
FAM168B	A1KXE4	23	51	1	195	Chain	ID=PRO_0000325978;Note=Myelin-associated neurite-outgrowth inhibitor
FAM168B	A1KXE4	23	51	19	42	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM168B	A1KXE4	23	51	19	42	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM168B	A1KXE4	23	51	43	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM168B	A1KXE4	23	51	43	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM168B	A1KXE4	23	51	46	46	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM168B	A1KXE4	23	51	46	46	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FAM162A	Q96A26	11	52	1	154	Chain	ID=PRO_0000254635;Note=Protein FAM162A
FAM162A	Q96A26	11	52	50	50	Natural variant	ID=VAR_028849;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17850692,PMID:15489334
FBXL20	Q96IG2	133	164	1	436	Chain	ID=PRO_0000119870;Note=F-box/LRR-repeat protein 20
FBXL20	Q96IG2	110	132	1	436	Chain	ID=PRO_0000119870;Note=F-box/LRR-repeat protein 20
FBXL20	Q96IG2	53	78	1	436	Chain	ID=PRO_0000119870;Note=F-box/LRR-repeat protein 20
FBXL20	Q96IG2	133	164	1	436	Chain	ID=PRO_0000119870;Note=F-box/LRR-repeat protein 20
FBXL20	Q96IG2	110	132	1	436	Chain	ID=PRO_0000119870;Note=F-box/LRR-repeat protein 20
FBXL20	Q96IG2	53	78	1	436	Chain	ID=PRO_0000119870;Note=F-box/LRR-repeat protein 20
FBXL20	Q96IG2	53	78	22	68	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXL20	Q96IG2	53	78	22	68	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
FBXL20	Q96IG2	53	78	74	100	Repeat	Note=LRR 1
FBXL20	Q96IG2	53	78	74	100	Repeat	Note=LRR 1
FBXL20	Q96IG2	110	132	101	126	Repeat	Note=LRR 2
FBXL20	Q96IG2	110	132	101	126	Repeat	Note=LRR 2
FBXL20	Q96IG2	133	164	127	152	Repeat	Note=LRR 3
FBXL20	Q96IG2	110	132	127	152	Repeat	Note=LRR 3
FBXL20	Q96IG2	133	164	127	152	Repeat	Note=LRR 3
FBXL20	Q96IG2	110	132	127	152	Repeat	Note=LRR 3
FBXL20	Q96IG2	133	164	153	178	Repeat	Note=LRR 4
FBXL20	Q96IG2	133	164	153	178	Repeat	Note=LRR 4
FBXL20	Q96IG2	133	164	134	165	Alternative sequence	ID=VSP_030769;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
FBXL20	Q96IG2	133	164	134	165	Alternative sequence	ID=VSP_030769;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
GPR137C	Q8N3F9	239	289	1	429	Chain	ID=PRO_0000304803;Note=Integral membrane protein GPR137C
GPR137C	Q8N3F9	239	289	227	246	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137C	Q8N3F9	239	289	247	267	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137C	Q8N3F9	239	289	268	300	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137C	Q8N3F9	239	289	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GPR137C	Q8N3F9	239	289	248	248	Natural variant	ID=VAR_053880;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs762063,PMID:17974005
GPR137C	Q8N3F9	239	289	239	239	Sequence conflict	Note=K->KITGSHSFLWLNSTPLC;Ontology_term=ECO:0000305;evidence=ECO:0000305
FLYWCH1	Q4VC44	416	504	1	716	Chain	ID=PRO_0000314460;Note=FLYWCH-type zinc finger-containing protein 1
FLYWCH1	Q4VC44	416	504	1	716	Chain	ID=PRO_0000314460;Note=FLYWCH-type zinc finger-containing protein 1
FLYWCH1	Q4VC44	504	592	1	716	Chain	ID=PRO_0000314460;Note=FLYWCH-type zinc finger-containing protein 1
FLYWCH1	Q4VC44	504	592	1	716	Chain	ID=PRO_0000314460;Note=FLYWCH-type zinc finger-containing protein 1
FLYWCH1	Q4VC44	592	683	1	716	Chain	ID=PRO_0000314460;Note=FLYWCH-type zinc finger-containing protein 1
FLYWCH1	Q4VC44	416	504	421	479	Zinc finger	Note=FLYWCH-type 3
FLYWCH1	Q4VC44	416	504	421	479	Zinc finger	Note=FLYWCH-type 3
FLYWCH1	Q4VC44	504	592	509	567	Zinc finger	Note=FLYWCH-type 4
FLYWCH1	Q4VC44	504	592	509	567	Zinc finger	Note=FLYWCH-type 4
FLYWCH1	Q4VC44	592	683	600	658	Zinc finger	Note=FLYWCH-type 5
FLYWCH1	Q4VC44	416	504	503	503	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
FLYWCH1	Q4VC44	416	504	503	503	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
FLYWCH1	Q4VC44	504	592	591	591	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
FLYWCH1	Q4VC44	504	592	591	591	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
FLYWCH1	Q4VC44	416	504	389	504	Alternative sequence	ID=VSP_030280;Note=In isoform 5. RKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSP->MPQATSPPLWPLSLHGGKGILWARHSHPPGPPSHHIQDSGRCSLPLPQSPGVTPLPARLSGATPLSPIRLLSSFVPRGPRVIPLTNQARRTLHASLGGCWGRTSDAADTASLKAWQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FLYWCH1	Q4VC44	416	504	389	504	Alternative sequence	ID=VSP_030280;Note=In isoform 5. RKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSP->MPQATSPPLWPLSLHGGKGILWARHSHPPGPPSHHIQDSGRCSLPLPQSPGVTPLPARLSGATPLSPIRLLSSFVPRGPRVIPLTNQARRTLHASLGGCWGRTSDAADTASLKAWQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FLYWCH1	Q4VC44	504	592	389	504	Alternative sequence	ID=VSP_030280;Note=In isoform 5. RKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSP->MPQATSPPLWPLSLHGGKGILWARHSHPPGPPSHHIQDSGRCSLPLPQSPGVTPLPARLSGATPLSPIRLLSSFVPRGPRVIPLTNQARRTLHASLGGCWGRTSDAADTASLKAWQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FLYWCH1	Q4VC44	504	592	389	504	Alternative sequence	ID=VSP_030280;Note=In isoform 5. RKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSP->MPQATSPPLWPLSLHGGKGILWARHSHPPGPPSHHIQDSGRCSLPLPQSPGVTPLPARLSGATPLSPIRLLSSFVPRGPRVIPLTNQARRTLHASLGGCWGRTSDAADTASLKAWQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FLYWCH1	Q4VC44	416	504	504	504	Alternative sequence	ID=VSP_030281;Note=In isoform 3. P->PGAGLSFQWLFRILQLLGHAPVLLCPSGSSCLPSLPAPHGPCPALSIPLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
FLYWCH1	Q4VC44	416	504	504	504	Alternative sequence	ID=VSP_030281;Note=In isoform 3. P->PGAGLSFQWLFRILQLLGHAPVLLCPSGSSCLPSLPAPHGPCPALSIPLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
FLYWCH1	Q4VC44	504	592	504	504	Alternative sequence	ID=VSP_030281;Note=In isoform 3. P->PGAGLSFQWLFRILQLLGHAPVLLCPSGSSCLPSLPAPHGPCPALSIPLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
FLYWCH1	Q4VC44	504	592	504	504	Alternative sequence	ID=VSP_030281;Note=In isoform 3. P->PGAGLSFQWLFRILQLLGHAPVLLCPSGSSCLPSLPAPHGPCPALSIPLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
FLYWCH1	Q4VC44	592	683	666	666	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FLYWCH1	Q4VC44	592	683	599	603	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	604	606	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	607	612	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	615	622	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	627	631	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	632	634	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	642	646	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	649	652	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
FLYWCH1	Q4VC44	592	683	662	670	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RPR
G2E3	Q7L622	212	250	1	706	Chain	ID=PRO_0000248343;Note=G2/M phase-specific E3 ubiquitin-protein ligase
G2E3	Q7L622	212	250	237	286	Zinc finger	Note=PHD-type 3
G2E3	Q7L622	212	250	232	232	Natural variant	ID=VAR_027273;Note=R->H;Dbxref=dbSNP:rs17096934
GAS2L3	Q86XJ1	216	252	1	694	Chain	ID=PRO_0000190446;Note=GAS2-like protein 3
GAS2L3	Q86XJ1	216	252	1	694	Chain	ID=PRO_0000190446;Note=GAS2-like protein 3
GAS2L3	Q86XJ1	216	252	1	694	Chain	ID=PRO_0000190446;Note=GAS2-like protein 3
GAS2L3	Q86XJ1	216	252	208	281	Domain	Note=GAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00792
GAS2L3	Q86XJ1	216	252	208	281	Domain	Note=GAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00792
GAS2L3	Q86XJ1	216	252	208	281	Domain	Note=GAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00792
ABAT	P80404	149	180	29	500	Chain	ID=PRO_0000001249;Note=4-aminobutyrate aminotransferase%2C mitochondrial
ABAT	P80404	180	201	29	500	Chain	ID=PRO_0000001249;Note=4-aminobutyrate aminotransferase%2C mitochondrial
ABAT	P80404	149	180	29	500	Chain	ID=PRO_0000001249;Note=4-aminobutyrate aminotransferase%2C mitochondrial
ABAT	P80404	180	201	29	500	Chain	ID=PRO_0000001249;Note=4-aminobutyrate aminotransferase%2C mitochondrial
ABAT	P80404	149	180	29	500	Chain	ID=PRO_0000001249;Note=4-aminobutyrate aminotransferase%2C mitochondrial
ABAT	P80404	180	201	29	500	Chain	ID=PRO_0000001249;Note=4-aminobutyrate aminotransferase%2C mitochondrial
ABAT	P80404	149	180	164	165	Region	Note=Pyridoxal phosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	164	165	Region	Note=Pyridoxal phosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	164	165	Region	Note=Pyridoxal phosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	163	163	Metal binding	Note=Iron-sulfur (2Fe-2S)%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	163	163	Metal binding	Note=Iron-sulfur (2Fe-2S)%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	163	163	Metal binding	Note=Iron-sulfur (2Fe-2S)%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	166	166	Metal binding	Note=Iron-sulfur (2Fe-2S)%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	166	166	Metal binding	Note=Iron-sulfur (2Fe-2S)%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	166	166	Metal binding	Note=Iron-sulfur (2Fe-2S)%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80147
ABAT	P80404	149	180	155	171	Sequence conflict	Note=MSQLITMACGSCSNENA->CPSSSPWPACPAPMKTT;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABAT	P80404	149	180	155	171	Sequence conflict	Note=MSQLITMACGSCSNENA->CPSSSPWPACPAPMKTT;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABAT	P80404	149	180	155	171	Sequence conflict	Note=MSQLITMACGSCSNENA->CPSSSPWPACPAPMKTT;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABAT	P80404	180	201	191	191	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABAT	P80404	180	201	191	191	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABAT	P80404	180	201	191	191	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
GAK	O14976	1094	1169	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	1055	1094	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	1014	1055	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	749	798	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	554	618	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	217	247	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	175	217	2	1311	Chain	ID=PRO_0000085958;Note=Cyclin-G-associated kinase
GAK	O14976	217	247	40	314	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GAK	O14976	175	217	40	314	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
GAK	O14976	554	618	399	566	Domain	Note=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
GAK	O14976	554	618	572	710	Domain	Note=C2 tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00589
GAK	O14976	749	798	770	770	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GAK	O14976	749	798	776	776	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GAK	O14976	749	798	783	783	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GAK	O14976	749	798	794	794	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GAK	O14976	1094	1169	1096	1096	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GAK	O14976	1094	1169	1123	1123	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KY4
GAK	O14976	554	618	580	580	Natural variant	ID=VAR_040506;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34255232,PMID:17344846
GAK	O14976	749	798	787	787	Natural variant	ID=VAR_040507;Note=D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34585705,PMID:17344846
GAK	O14976	1014	1055	1051	1051	Natural variant	ID=VAR_040510;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35227944,PMID:17344846
GAK	O14976	1094	1169	1120	1120	Natural variant	ID=VAR_040511;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55801437,PMID:17344846
GAK	O14976	1094	1169	1137	1137	Natural variant	ID=VAR_040512;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56169884,PMID:17344846
GAK	O14976	1094	1169	1168	1168	Natural variant	ID=VAR_040513;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56326341,PMID:17344846
GAK	O14976	554	618	607	607	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
GAK	O14976	1094	1169	1113	1113	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
GAK	O14976	175	217	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O38
GAK	O14976	175	217	179	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y8D
GAK	O14976	175	217	187	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O38
GAK	O14976	217	247	208	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C57
GAK	O14976	175	217	208	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C57
GAK	O14976	217	247	224	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C57
GAK	O14976	217	247	229	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C57
GAK	O14976	217	247	242	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O38
HAMP	P81172	30	50	25	54	Propeptide	ID=PRO_0000013378
HAMP	P81172	30	50	25	54	Propeptide	ID=PRO_0000013378
HAMP	P81172	30	50	31	31	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
HAMP	P81172	30	50	31	31	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
HEPH	Q9BQS7	137	208	24	1158	Chain	ID=PRO_0000002915;Note=Hephaestin
HEPH	Q9BQS7	621	692	24	1158	Chain	ID=PRO_0000002915;Note=Hephaestin
HEPH	Q9BQS7	137	208	24	1110	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HEPH	Q9BQS7	621	692	24	1110	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HEPH	Q9BQS7	137	208	24	206	Domain	Note=Plastocyanin-like 1
HEPH	Q9BQS7	621	692	570	718	Domain	Note=Plastocyanin-like 4
HEPH	Q9BQS7	137	208	186	186	Metal binding	Note=Copper 2%3B type 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
HEPH	Q9BQS7	137	208	188	188	Metal binding	Note=Copper 3%3B type 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
HEPH	Q9BQS7	621	692	656	656	Metal binding	Note=Copper 5%3B type 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
HEPH	Q9BQS7	137	208	164	164	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HEPH	Q9BQS7	137	208	180	206	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
HEPH	Q9BQS7	621	692	637	718	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
HEPH	Q9BQS7	137	208	1	267	Alternative sequence	ID=VSP_047332;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HERC3	Q15034	599	637	1	1050	Chain	ID=PRO_0000206651;Note=Probable E3 ubiquitin-protein ligase HERC3
HERC3	Q15034	675	732	1	1050	Chain	ID=PRO_0000206651;Note=Probable E3 ubiquitin-protein ligase HERC3
HERC3	Q15034	599	637	1	1050	Chain	ID=PRO_0000206651;Note=Probable E3 ubiquitin-protein ligase HERC3
HERC3	Q15034	675	732	1	1050	Chain	ID=PRO_0000206651;Note=Probable E3 ubiquitin-protein ligase HERC3
HERC3	Q15034	599	637	369	1050	Alternative sequence	ID=VSP_056344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HERC3	Q15034	675	732	369	1050	Alternative sequence	ID=VSP_056344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HERC3	Q15034	599	637	369	1050	Alternative sequence	ID=VSP_056344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HERC3	Q15034	675	732	369	1050	Alternative sequence	ID=VSP_056344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HERC4	Q5GLZ8	154	228	1	1057	Chain	ID=PRO_0000278216;Note=Probable E3 ubiquitin-protein ligase HERC4
HERC4	Q5GLZ8	154	228	102	154	Repeat	Note=RCC1 3
HERC4	Q5GLZ8	154	228	156	207	Repeat	Note=RCC1 4
HERC4	Q5GLZ8	154	228	208	259	Repeat	Note=RCC1 5
HERC4	Q5GLZ8	154	228	111	1057	Alternative sequence	ID=VSP_023175;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15676274;Dbxref=PMID:15676274
HERC4	Q5GLZ8	154	228	118	1057	Alternative sequence	ID=VSP_023176;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15676274;Dbxref=PMID:15489334,PMID:15676274
HERC5	Q9UII4	155	229	1	1024	Chain	ID=PRO_0000206641;Note=E3 ISG15--protein ligase HERC5
HERC5	Q9UII4	413	432	1	1024	Chain	ID=PRO_0000206641;Note=E3 ISG15--protein ligase HERC5
HERC5	Q9UII4	579	617	1	1024	Chain	ID=PRO_0000206641;Note=E3 ISG15--protein ligase HERC5
HERC5	Q9UII4	617	654	1	1024	Chain	ID=PRO_0000206641;Note=E3 ISG15--protein ligase HERC5
HERC5	Q9UII4	654	711	1	1024	Chain	ID=PRO_0000206641;Note=E3 ISG15--protein ligase HERC5
HERC5	Q9UII4	155	229	96	155	Repeat	Note=RCC1 1
HERC5	Q9UII4	155	229	156	208	Repeat	Note=RCC1 2
HERC5	Q9UII4	155	229	209	260	Repeat	Note=RCC1 3
HERC5	Q9UII4	654	711	702	1024	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
HERC5	Q9UII4	155	229	204	204	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
HERC5	Q9UII4	413	432	419	419	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HERPUD1	Q15011	75	100	1	391	Chain	ID=PRO_0000114920;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
HERPUD1	Q15011	144	184	1	391	Chain	ID=PRO_0000114920;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
HERPUD1	Q15011	185	301	1	391	Chain	ID=PRO_0000114920;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
HERPUD1	Q15011	75	100	1	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD1	Q15011	144	184	1	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD1	Q15011	185	301	1	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD1	Q15011	185	301	264	284	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD1	Q15011	185	301	285	289	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD1	Q15011	185	301	290	310	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD1	Q15011	144	184	115	200	Region	Note=Interaction with UBQLN1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18307982;Dbxref=PMID:18307982
HERPUD1	Q15011	185	301	115	200	Region	Note=Interaction with UBQLN1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18307982;Dbxref=PMID:18307982
HERPUD1	Q15011	75	100	75	99	Alternative sequence	ID=VSP_047333;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HERPUD1	Q15011	75	100	76	76	Alternative sequence	ID=VSP_006708;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
HERPUD1	Q15011	144	184	145	302	Alternative sequence	ID=VSP_006709;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HERPUD1	Q15011	185	301	145	302	Alternative sequence	ID=VSP_006709;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HERPUD1	Q15011	75	100	75	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGD
HERPUD1	Q15011	75	100	79	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WGD
HERPUD2	Q9BSE4	206	313	1	406	Chain	ID=PRO_0000280627;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
HERPUD2	Q9BSE4	75	113	1	406	Chain	ID=PRO_0000280627;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
HERPUD2	Q9BSE4	49	75	1	406	Chain	ID=PRO_0000280627;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
HERPUD2	Q9BSE4	206	313	1	406	Chain	ID=PRO_0000280627;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
HERPUD2	Q9BSE4	75	113	1	406	Chain	ID=PRO_0000280627;Note=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
HERPUD2	Q9BSE4	206	313	302	322	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD2	Q9BSE4	206	313	302	322	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
HERPUD2	Q9BSE4	75	113	10	89	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
HERPUD2	Q9BSE4	49	75	10	89	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
HERPUD2	Q9BSE4	75	113	10	89	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
HERPUD2	Q9BSE4	75	113	93	138	Compositional bias	Note=Ser-rich
HERPUD2	Q9BSE4	75	113	93	138	Compositional bias	Note=Ser-rich
HERPUD2	Q9BSE4	75	113	108	108	Natural variant	ID=VAR_031182;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3779234,PMID:15489334
HERPUD2	Q9BSE4	75	113	108	108	Natural variant	ID=VAR_031182;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3779234,PMID:15489334
HERPUD2	Q9BSE4	49	75	51	53	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	49	75	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	49	75	61	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	49	75	70	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	75	113	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	49	75	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	75	113	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	75	113	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
HERPUD2	Q9BSE4	75	113	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDB
GATM	P50440	347	386	38	423	Chain	ID=PRO_0000001206;Note=Glycine amidinotransferase%2C mitochondrial
GATM	P50440	225	271	38	423	Chain	ID=PRO_0000001206;Note=Glycine amidinotransferase%2C mitochondrial
GATM	P50440	225	271	254	254	Active site	.
GATM	P50440	347	386	385	385	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GATM	P50440	225	271	231	231	Natural variant	ID=VAR_076491;Note=Decreases glycine amidinotransferase activity. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27233232;Dbxref=dbSNP:rs202225656,PMID:27233232
GATM	P50440	225	271	234	234	Natural variant	ID=VAR_076492;Note=Decreases glycine amidinotransferase activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27233232;Dbxref=dbSNP:rs146057680,PMID:27233232
GATM	P50440	225	271	233	233	Mutagenesis	Note=Complete loss of activity%3B when associated with S-407. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9266688;Dbxref=PMID:9266688
GATM	P50440	225	271	254	254	Mutagenesis	Note=Significantly reduced activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9266688;Dbxref=PMID:9266688
GATM	P50440	347	386	355	355	Mutagenesis	Note=Significantly reduced activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9266688;Dbxref=PMID:9266688
GATM	P50440	225	271	246	246	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
GATM	P50440	347	386	384	384	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
GATM	P50440	225	271	232	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	225	271	248	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	225	271	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	225	271	258	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	225	271	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	347	386	352	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	347	386	356	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	347	386	363	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	347	386	369	373	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
GATM	P50440	347	386	377	385	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDW
HID1	Q8IV36	715	767	2	788	Chain	ID=PRO_0000079296;Note=Protein HID1
HID1	Q8IV36	204	242	2	788	Chain	ID=PRO_0000079296;Note=Protein HID1
HID1	Q8IV36	72	129	2	788	Chain	ID=PRO_0000079296;Note=Protein HID1
HID1	Q8IV36	22	72	2	788	Chain	ID=PRO_0000079296;Note=Protein HID1
HID1	Q8IV36	204	242	30	257	Alternative sequence	ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HID1	Q8IV36	72	129	30	257	Alternative sequence	ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HID1	Q8IV36	22	72	30	257	Alternative sequence	ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GNB2	P62879	19	32	2	340	Chain	ID=PRO_0000127695;Note=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
GNB2	P62879	19	32	2	340	Chain	ID=PRO_0000127695;Note=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
GNB2	P62879	19	32	2	340	Chain	ID=PRO_0000127695;Note=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
GNB2	P62879	19	32	1	100	Alternative sequence	ID=VSP_056515;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNB2	P62879	19	32	1	100	Alternative sequence	ID=VSP_056515;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNB2	P62879	19	32	1	100	Alternative sequence	ID=VSP_056515;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GNB4	Q9HAV0	19	32	2	340	Chain	ID=PRO_0000127702;Note=Guanine nucleotide-binding protein subunit beta-4
GNB4	Q9HAV0	19	32	2	340	Chain	ID=PRO_0000127702;Note=Guanine nucleotide-binding protein subunit beta-4
GNB1	P62873	19	32	2	340	Chain	ID=PRO_0000127687;Note=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
GNB1	P62873	19	32	30	30	Natural variant	ID=VAR_078279;Note=In MRD42%3B unknown pathological significance%3B no effect on protein abundance%3B no effect on complex formation with gamma subunit%3B no effect on trimer formation with alpha and gamma subunits%3B no effect on receptor-driven G protein activation. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28087732;Dbxref=dbSNP:rs764997309,PMID:28087732
GNB1	P62873	19	32	3	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UKL
GNB1	P62873	19	32	30	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UKL
GBP4	Q96PP9	223	305	1	640	Chain	ID=PRO_0000190968;Note=Guanylate-binding protein 4
GBP4	Q96PP9	223	305	50	292	Domain	Note=GB1/RHD3-type G
GBP4	Q96PP9	223	305	1	325	Region	Note=GTPase domain (Globular);Ontology_term=ECO:0000250;evidence=ECO:0000250
GBP4	Q96PP9	223	305	298	298	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC25A16	P16260	43	74	1	332	Chain	ID=PRO_0000090616;Note=Graves disease carrier protein
SLC25A16	P16260	43	74	37	57	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A16	P16260	43	74	34	120	Repeat	Note=Solcar 1
SLC25A16	P16260	43	74	44	44	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
GDE1	Q9NZC3	181	212	1	331	Chain	ID=PRO_0000251944;Note=Glycerophosphodiester phosphodiesterase 1
GDE1	Q9NZC3	181	212	25	247	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDE1	Q9NZC3	181	212	65	331	Domain	Note=GP-PDE
GDE1	Q9NZC3	181	212	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EHD1	Q9H4M9	305	360	1	534	Chain	ID=PRO_0000146109;Note=EH domain-containing protein 1
EHD1	Q9H4M9	305	360	1	534	Chain	ID=PRO_0000146109;Note=EH domain-containing protein 1
EHD1	Q9H4M9	305	360	355	355	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EHD1	Q9H4M9	305	360	355	355	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EGF	P01133	313	355	23	1207	Chain	ID=PRO_0000007540;Note=Pro-epidermal growth factor
EGF	P01133	830	869	23	1207	Chain	ID=PRO_0000007540;Note=Pro-epidermal growth factor
EGF	P01133	911	952	23	1207	Chain	ID=PRO_0000007540;Note=Pro-epidermal growth factor
EGF	P01133	1002	1057	23	1207	Chain	ID=PRO_0000007540;Note=Pro-epidermal growth factor
EGF	P01133	1002	1057	971	1023	Chain	ID=PRO_0000007541;Note=Epidermal growth factor
EGF	P01133	313	355	23	1032	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	830	869	23	1032	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	911	952	23	1032	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	1002	1057	23	1032	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	1002	1057	1033	1053	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	1002	1057	1054	1207	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	313	355	314	355	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	830	869	831	869	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	911	952	870	911	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	911	952	912	952	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	1002	1057	972	1013	Domain	Note=EGF-like 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	313	355	324	324	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	911	952	926	926	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EGF	P01133	313	355	318	330	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	313	355	325	339	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	313	355	341	354	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	830	869	835	846	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	830	869	840	855	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	830	869	857	868	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	911	952	916	929	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	911	952	923	938	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	911	952	940	951	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
EGF	P01133	1002	1057	1003	1012	Disulfide bond	.
EGF	P01133	313	355	314	355	Alternative sequence	ID=VSP_041586;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EGF	P01133	911	952	912	952	Alternative sequence	ID=VSP_047190;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EGF	P01133	830	869	842	842	Natural variant	ID=VAR_020165;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569046
EGF	P01133	911	952	920	920	Natural variant	ID=VAR_020970;Note=E->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.2;Dbxref=dbSNP:rs4698803,PMID:14702039
EGF	P01133	1002	1057	1043	1043	Natural variant	ID=VAR_020166;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569098
EGF	P01133	1002	1057	998	1003	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NQL
EGF	P01133	1002	1057	1007	1009	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NQL
EGF	P01133	1002	1057	1018	1021	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P9J
EI24	O14681	147	187	2	340	Chain	ID=PRO_0000086945;Note=Etoposide-induced protein 2.4 homolog
EI24	O14681	147	187	179	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF3A	Q14152	481	543	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	374	409	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	447	509	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	340	375	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	481	543	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	374	409	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	447	509	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	340	375	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	481	543	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
EIF3A	Q14152	447	509	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
EIF3A	Q14152	374	409	386	386	Natural variant	ID=VAR_024438;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs967185,PMID:14702039
EIF3A	Q14152	481	543	520	520	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF3A	Q14152	340	375	336	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	340	375	346	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	340	375	354	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	367	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	340	375	367	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	377	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	385	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	400	416	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	448	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	452	458	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	464	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	481	543	483	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	483	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	481	543	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	481	543	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	388	433	2	445	Chain	ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E
EIF3E	P60228	283	317	2	445	Chain	ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E
EIF3E	P60228	122	157	2	445	Chain	ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E
EIF3E	P60228	388	433	221	398	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3E	P60228	283	317	221	398	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3E	P60228	122	157	4	128	Region	Note=Sufficient for interaction with EPAS1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17324924;Dbxref=PMID:17324924
EIF3E	P60228	122	157	9	195	Region	Note=Sufficient for interaction with TRIM27;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10504338;Dbxref=PMID:10504338
EIF3E	P60228	388	433	351	445	Region	Note=Sufficient for interaction with MCM7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310990;Dbxref=PMID:17310990
EIF3E	P60228	388	433	399	399	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
EIF3E	P60228	283	317	312	312	Mutagenesis	Note=Promotes nuclear accumulation. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17761670;Dbxref=PMID:17761670
EIF3E	P60228	122	157	124	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	122	157	144	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	283	317	281	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	283	317	291	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	283	317	305	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	388	433	386	389	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	388	433	390	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF3G	O75821	100	135	2	320	Chain	ID=PRO_0000123510;Note=Eukaryotic translation initiation factor 3 subunit G
EIF3I	Q13347	1	32	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
EIF3I	Q13347	83	133	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
EIF3I	Q13347	213	243	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
EIF3I	Q13347	1	32	1	39	Repeat	Note=WD 1
EIF3I	Q13347	83	133	87	127	Repeat	Note=WD 3
EIF3I	Q13347	213	243	180	217	Repeat	Note=WD 5
EIF3I	Q13347	213	243	221	267	Repeat	Note=WD 6
EIF3I	Q13347	213	243	219	219	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EIF3J	O75822	136	190	2	258	Chain	ID=PRO_0000123506;Note=Eukaryotic translation initiation factor 3 subunit J
EIF3J	O75822	136	190	137	191	Alternative sequence	ID=VSP_054593;Note=In isoform 2. GVNNAVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISL->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EIF3J	O75822	136	190	141	141	Natural variant	ID=VAR_034007;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2303578,PMID:14702039
EIF3J	O75822	136	190	145	147	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF3J	O75822	136	190	153	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF3J	O75822	136	190	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF3J	O75822	136	190	176	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
ELK1	P19419	218	362	1	428	Chain	ID=PRO_0000204095;Note=ETS domain-containing protein Elk-1
ELK1	P19419	218	362	1	428	Chain	ID=PRO_0000204095;Note=ETS domain-containing protein Elk-1
ELK1	P19419	218	362	349	399	Region	Note=Sufficient for interaction with MAD2L2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17296730;Dbxref=PMID:17296730
ELK1	P19419	218	362	349	399	Region	Note=Sufficient for interaction with MAD2L2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17296730;Dbxref=PMID:17296730
ELK1	P19419	218	362	324	324	Modified residue	Note=Phosphoserine%3B by MAPK1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:7889942;Dbxref=PMID:19690332,PMID:23186163,PMID:7889942
ELK1	P19419	218	362	324	324	Modified residue	Note=Phosphoserine%3B by MAPK1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:7889942;Dbxref=PMID:19690332,PMID:23186163,PMID:7889942
ELK1	P19419	218	362	336	336	Modified residue	Note=Phosphothreonine%3B by MAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	336	336	Modified residue	Note=Phosphothreonine%3B by MAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	353	353	Modified residue	Note=Phosphothreonine%3B by MAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10637505;Dbxref=PMID:10637505
ELK1	P19419	218	362	353	353	Modified residue	Note=Phosphothreonine%3B by MAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10637505;Dbxref=PMID:10637505
ELK1	P19419	218	362	230	230	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210726;Dbxref=PMID:15210726
ELK1	P19419	218	362	230	230	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210726;Dbxref=PMID:15210726
ELK1	P19419	218	362	249	249	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12887893,ECO:0000269|PubMed:15210726;Dbxref=PMID:12887893,PMID:15210726
ELK1	P19419	218	362	249	249	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12887893,ECO:0000269|PubMed:15210726;Dbxref=PMID:12887893,PMID:15210726
ELK1	P19419	218	362	254	254	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210726;Dbxref=PMID:15210726
ELK1	P19419	218	362	254	254	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210726;Dbxref=PMID:15210726
ELK1	P19419	218	362	96	428	Alternative sequence	ID=VSP_001467;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK1	P19419	218	362	96	428	Alternative sequence	ID=VSP_001467;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELK1	P19419	218	362	230	230	Mutagenesis	Note=9-fold increase in transcriptional activator activity%3B when associated with R-249. Reduction in sumoylation. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12887893,ECO:0000269|PubMed:15210726;Dbxref=PMID:12887893,PMID:15210726
ELK1	P19419	218	362	230	230	Mutagenesis	Note=9-fold increase in transcriptional activator activity%3B when associated with R-249. Reduction in sumoylation. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12887893,ECO:0000269|PubMed:15210726;Dbxref=PMID:12887893,PMID:15210726
ELK1	P19419	218	362	249	249	Mutagenesis	Note=9-fold increase in transcriptional activator activity%3B when associated with R-230. Reduction in sumoylation. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12887893,ECO:0000269|PubMed:15210726;Dbxref=PMID:12887893,PMID:15210726
ELK1	P19419	218	362	249	249	Mutagenesis	Note=9-fold increase in transcriptional activator activity%3B when associated with R-230. Reduction in sumoylation. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12887893,ECO:0000269|PubMed:15210726;Dbxref=PMID:12887893,PMID:15210726
ELK1	P19419	218	362	254	254	Mutagenesis	Note=Reduction in sumoylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210726;Dbxref=PMID:15210726
ELK1	P19419	218	362	254	254	Mutagenesis	Note=Reduction in sumoylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210726;Dbxref=PMID:15210726
ELK1	P19419	218	362	324	324	Mutagenesis	Note=No effect on ternary complex formation but loss of transcriptional activity positive regulation by MAD2L2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	324	324	Mutagenesis	Note=No effect on ternary complex formation but loss of transcriptional activity positive regulation by MAD2L2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	336	336	Mutagenesis	Note=No effect on ternary complex formation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	336	336	Mutagenesis	Note=No effect on ternary complex formation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	353	353	Mutagenesis	Note=No effect on ternary complex formation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELK1	P19419	218	362	353	353	Mutagenesis	Note=No effect on ternary complex formation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7889942;Dbxref=PMID:7889942
ELF3	P78545	128	159	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	159	199	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	199	229	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	54	128	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	128	159	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	159	199	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	199	229	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	54	128	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	128	159	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	159	199	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	199	229	1	371	Chain	ID=PRO_0000287681;Note=ETS-related transcription factor Elf-3
ELF3	P78545	128	159	46	132	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF3	P78545	54	128	46	132	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF3	P78545	128	159	46	132	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF3	P78545	54	128	46	132	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF3	P78545	128	159	46	132	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF3	P78545	128	159	137	145	Motif	Note=9aaTAD
ELF3	P78545	128	159	137	145	Motif	Note=9aaTAD
ELF3	P78545	128	159	137	145	Motif	Note=9aaTAD
ELF3	P78545	159	199	173	195	Alternative sequence	ID=VSP_052433;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9234700;Dbxref=PMID:9234700
ELF3	P78545	159	199	173	195	Alternative sequence	ID=VSP_052433;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9234700;Dbxref=PMID:9234700
ELF3	P78545	159	199	173	195	Alternative sequence	ID=VSP_052433;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9234700;Dbxref=PMID:9234700
ELF3	P78545	54	128	55	56	Sequence conflict	Note=EK->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	54	128	55	56	Sequence conflict	Note=EK->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	54	128	68	68	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	54	128	68	68	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	128	159	129	130	Sequence conflict	Note=TS->SA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	128	159	129	130	Sequence conflict	Note=TS->SA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	128	159	129	130	Sequence conflict	Note=TS->SA;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	128	159	134	134	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	128	159	134	134	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	128	159	134	134	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	159	199	160	161	Sequence conflict	Note=DQ->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	159	199	160	161	Sequence conflict	Note=DQ->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	159	199	160	161	Sequence conflict	Note=DQ->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	199	229	201	201	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	199	229	201	201	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	199	229	201	201	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELF3	P78545	54	128	60	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	60	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	64	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	64	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	69	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	69	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	92	94	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	100	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	100	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	107	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	107	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	128	159	118	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	118	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	128	159	118	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	54	128	118	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF3	P78545	128	159	118	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E8P
ELF5	Q9UKW6	145	168	1	265	Chain	ID=PRO_0000204092;Note=ETS-related transcription factor Elf-5
ELF5	Q9UKW6	128	145	1	265	Chain	ID=PRO_0000204092;Note=ETS-related transcription factor Elf-5
ELF5	Q9UKW6	50	128	1	265	Chain	ID=PRO_0000204092;Note=ETS-related transcription factor Elf-5
ELF5	Q9UKW6	128	145	43	129	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF5	Q9UKW6	50	128	43	129	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ELF5	Q9UKW6	145	168	51	146	Alternative sequence	ID=VSP_054662;Note=In isoform 4. ACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYFILQNIRTQGYSFFNDAEESKATIKDY->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9840936;Dbxref=PMID:9840936
ELF5	Q9UKW6	128	145	51	146	Alternative sequence	ID=VSP_054662;Note=In isoform 4. ACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYFILQNIRTQGYSFFNDAEESKATIKDY->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9840936;Dbxref=PMID:9840936
ELF5	Q9UKW6	50	128	51	146	Alternative sequence	ID=VSP_054662;Note=In isoform 4. ACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYFILQNIRTQGYSFFNDAEESKATIKDY->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9840936;Dbxref=PMID:9840936
ELF5	Q9UKW6	145	168	130	148	Alternative sequence	ID=VSP_014511;Note=In isoform 3. YSFFNDAEESKATIKDYAD->QCSEGQTSRGGTRIRTKQL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELF5	Q9UKW6	128	145	130	148	Alternative sequence	ID=VSP_014511;Note=In isoform 3. YSFFNDAEESKATIKDYAD->QCSEGQTSRGGTRIRTKQL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELF5	Q9UKW6	145	168	149	265	Alternative sequence	ID=VSP_014512;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELOVL6	Q9H5J4	30	73	1	265	Chain	ID=PRO_0000282845;Note=Elongation of very long chain fatty acids protein 6
ELOVL6	Q9H5J4	30	73	1	265	Chain	ID=PRO_0000282845;Note=Elongation of very long chain fatty acids protein 6
ELOVL6	Q9H5J4	30	73	34	51	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03206
ELOVL6	Q9H5J4	30	73	34	51	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03206
ELOVL6	Q9H5J4	30	73	70	90	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03206
ELOVL6	Q9H5J4	30	73	70	90	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03206
ELOVL1	Q9BW60	106	125	1	279	Chain	ID=PRO_0000207536;Note=Elongation of very long chain fatty acids protein 1
ELOVL1	Q9BW60	79	106	1	279	Chain	ID=PRO_0000207536;Note=Elongation of very long chain fatty acids protein 1
ELOVL1	Q9BW60	79	106	61	81	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03201
ELOVL1	Q9BW60	106	125	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03201
ELOVL1	Q9BW60	106	125	80	106	Alternative sequence	ID=VSP_045436;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ELOVL1	Q9BW60	79	106	80	106	Alternative sequence	ID=VSP_045436;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GRSF1	Q12849	171	223	118	480	Chain	ID=PRO_0000081597;Note=G-rich sequence factor 1
GRSF1	Q12849	171	223	122	246	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
GRSF1	Q12849	171	223	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	178	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	182	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	192	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	203	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	211	214	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	215	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
GRSF1	Q12849	171	223	220	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QU6
EMC2	Q15006	234	269	2	297	Chain	ID=PRO_0000106353;Note=ER membrane protein complex subunit 2
EMC2	Q15006	234	269	255	255	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
EMC7	Q9NPA0	165	192	24	242	Chain	ID=PRO_0000240860;Note=ER membrane protein complex subunit 7
EMC7	Q9NPA0	165	192	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMC7	Q9NPA0	165	192	181	242	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EME1	Q96AY2	301	330	1	570	Chain	ID=PRO_0000223630;Note=Crossover junction endonuclease EME1
EME1	Q96AY2	301	330	301	303	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P0P
EME1	Q96AY2	301	330	312	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZIU
EME1	Q96AY2	301	330	318	326	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZIU
EMP3	P54852	60	107	1	163	Chain	ID=PRO_0000164660;Note=Epithelial membrane protein 3
EMP3	P54852	60	107	1	163	Chain	ID=PRO_0000164660;Note=Epithelial membrane protein 3
EMP3	P54852	60	107	66	86	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP3	P54852	60	107	66	86	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP3	P54852	60	107	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP3	P54852	60	107	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMP3	P54852	60	107	100	101	Sequence conflict	Note=TG->HR;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMP3	P54852	60	107	100	101	Sequence conflict	Note=TG->HR;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMILIN1	Q9Y6C2	170	813	22	1016	Chain	ID=PRO_0000007815;Note=EMILIN-1
EMILIN1	Q9Y6C2	858	904	22	1016	Chain	ID=PRO_0000007815;Note=EMILIN-1
EMILIN1	Q9Y6C2	858	904	814	864	Domain	Note=Collagen-like
EMILIN1	Q9Y6C2	858	904	866	1013	Domain	Note=C1q;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00368
EMILIN1	Q9Y6C2	170	813	216	256	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN1	Q9Y6C2	170	813	356	420	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN1	Q9Y6C2	170	813	576	603	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN1	Q9Y6C2	170	813	685	752	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN1	Q9Y6C2	170	813	415	415	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
EMILIN1	Q9Y6C2	170	813	455	455	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16263699,ECO:0000269|PubMed:19159218;Dbxref=PMID:16263699,PMID:19159218
EMILIN1	Q9Y6C2	170	813	561	561	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN1	Q9Y6C2	170	813	658	658	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN1	Q9Y6C2	170	813	766	766	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
EMILIN1	Q9Y6C2	170	813	794	794	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
EMILIN1	Q9Y6C2	170	813	1	674	Alternative sequence	ID=VSP_055478;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMILIN1	Q9Y6C2	170	813	675	675	Alternative sequence	ID=VSP_055479;Note=In isoform 2. L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMILIN1	Q9Y6C2	170	813	813	813	Alternative sequence	ID=VSP_055480;Note=In isoform 2. T->TGEGTK;Ontology_term=ECO:0000305;evidence=ECO:0000305
EMILIN1	Q9Y6C2	170	813	536	536	Natural variant	ID=VAR_046096;Note=Q->R;Dbxref=dbSNP:rs36069611
EMILIN1	Q9Y6C2	858	904	903	903	Natural variant	ID=VAR_046097;Note=E->K;Dbxref=dbSNP:rs36045790
EMILIN1	Q9Y6C2	858	904	872	876	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KA3
EMILIN1	Q9Y6C2	858	904	884	886	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KA3
EMILIN1	Q9Y6C2	858	904	891	897	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KA3
EMILIN1	Q9Y6C2	858	904	902	905	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KA3
EMILIN2	Q9BXX0	144	786	31	1053	Chain	ID=PRO_0000007817;Note=EMILIN-2
EMILIN2	Q9BXX0	786	887	31	1053	Chain	ID=PRO_0000007817;Note=EMILIN-2
EMILIN2	Q9BXX0	887	898	31	1053	Chain	ID=PRO_0000007817;Note=EMILIN-2
EMILIN2	Q9BXX0	898	941	31	1053	Chain	ID=PRO_0000007817;Note=EMILIN-2
EMILIN2	Q9BXX0	786	887	840	892	Domain	Note=Collagen-like
EMILIN2	Q9BXX0	887	898	840	892	Domain	Note=Collagen-like
EMILIN2	Q9BXX0	898	941	901	1052	Domain	Note=C1q;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00368
EMILIN2	Q9BXX0	144	786	177	215	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	253	340	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	369	389	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	578	634	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	784	839	Compositional bias	Note=Pro-rich
EMILIN2	Q9BXX0	786	887	784	839	Compositional bias	Note=Pro-rich
EMILIN2	Q9BXX0	887	898	893	901	Compositional bias	Note=Pro-rich
EMILIN2	Q9BXX0	898	941	893	901	Compositional bias	Note=Pro-rich
EMILIN2	Q9BXX0	144	786	275	275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	458	458	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	510	510	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	587	587	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	616	616	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
EMILIN2	Q9BXX0	144	786	745	745	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
EMILIN2	Q9BXX0	144	786	215	215	Natural variant	ID=VAR_057528;Note=A->T;Dbxref=dbSNP:rs16943977
EMILIN2	Q9BXX0	144	786	259	259	Natural variant	ID=VAR_057529;Note=M->V;Dbxref=dbSNP:rs35267664
EMILIN2	Q9BXX0	898	941	903	903	Natural variant	ID=VAR_062003;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278945;Dbxref=dbSNP:rs56288451,PMID:11278945
EMILIN2	Q9BXX0	144	786	545	545	Sequence conflict	Note=K->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ENOX1	Q8TC92	518	537	1	643	Chain	ID=PRO_0000295900;Note=Ecto-NOX disulfide-thiol exchanger 1
ENOX1	Q8TC92	518	537	425	570	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ENOX1	Q8TC92	518	537	423	643	Alternative sequence	ID=VSP_056987;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GSTM2	P28161	152	189	1	218	Chain	ID=PRO_0000185818;Note=Glutathione S-transferase Mu 2
GSTM2	P28161	152	189	90	208	Domain	Note=GST C-terminal
GSTM2	P28161	152	189	173	173	Natural variant	ID=VAR_049486;Note=S->N;Dbxref=dbSNP:rs2229050
GSTM2	P28161	152	189	150	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C4J
GSTM2	P28161	152	189	155	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C4J
GSTM2	P28161	152	189	172	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C4J
GSTM2	P28161	152	189	179	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C4J
HSP90B1	P14625	98	137	22	803	Chain	ID=PRO_0000013598;Note=Endoplasmin
HSP90B1	P14625	325	364	22	803	Chain	ID=PRO_0000013598;Note=Endoplasmin
HSP90B1	P14625	364	410	22	803	Chain	ID=PRO_0000013598;Note=Endoplasmin
HSP90B1	P14625	98	137	107	107	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
HSP90B1	P14625	364	410	403	403	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q66HD0
HSP90B1	P14625	364	410	404	404	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08113
HSP90B1	P14625	98	137	107	107	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16263699,ECO:0000269|PubMed:19159218;Dbxref=PMID:16263699,PMID:19159218
HSP90B1	P14625	98	137	99	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NH9
HSP90B1	P14625	98	137	119	121	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NH9
HSP90B1	P14625	98	137	123	128	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NH9
HSP90B1	P14625	98	137	134	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NH9
HSP90B1	P14625	325	364	331	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NH9
ESD	P10768	167	200	2	282	Chain	ID=PRO_0000210339;Note=S-formylglutathione hydrolase
ESD	P10768	52	85	2	282	Chain	ID=PRO_0000210339;Note=S-formylglutathione hydrolase
ESD	P10768	167	200	200	200	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ESD	P10768	167	200	190	190	Natural variant	ID=VAR_005202;Note=In allele ESD*2. G->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12721789,ECO:0000269|PubMed:7907313;Dbxref=dbSNP:rs9778,PMID:12721789,PMID:7907313
ESD	P10768	52	85	54	54	Mutagenesis	Note=83%25 of wild-type activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19126594;Dbxref=PMID:19126594
ESD	P10768	52	85	59	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESD	P10768	52	85	68	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESD	P10768	52	85	77	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESD	P10768	167	200	169	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESD	P10768	167	200	178	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESD	P10768	167	200	182	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESD	P10768	167	200	199	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCX
ESYT1	Q9BSJ8	130	144	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	491	515	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	544	594	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	646	705	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	779	811	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	835	864	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	864	911	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	963	995	1	1104	Chain	ID=PRO_0000234344;Note=Extended synaptotagmin-1
ESYT1	Q9BSJ8	130	144	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	491	515	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	544	594	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	646	705	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	779	811	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	835	864	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	864	911	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	963	995	84	1104	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ESYT1	Q9BSJ8	130	144	135	313	Domain	Note=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
ESYT1	Q9BSJ8	491	515	465	558	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	544	594	465	558	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	646	705	634	735	Domain	Note=C2 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	779	811	785	877	Domain	Note=C2 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	835	864	785	877	Domain	Note=C2 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	864	911	785	877	Domain	Note=C2 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	963	995	972	1077	Domain	Note=C2 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
ESYT1	Q9BSJ8	963	995	963	963	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
ESYT1	Q9BSJ8	491	515	491	491	Alternative sequence	ID=VSP_018277;Note=In isoform 2. P->PMVTSELYPPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9872452;Dbxref=PMID:9872452
ESYT1	Q9BSJ8	646	705	663	663	Mutagenesis	Note=Abolishes location at the cell membrane%3B when associated with A-675 and 722-A--A-729. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23791178;Dbxref=PMID:23791178
ESYT1	Q9BSJ8	646	705	675	675	Mutagenesis	Note=Abolishes location at the cell membrane%3B when associated with A-675 and 722-A--A-729. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23791178;Dbxref=PMID:23791178
ESYT1	Q9BSJ8	130	144	133	133	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ESYT1	Q9BSJ8	779	811	785	785	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ETFB	P38117	72	125	2	255	Chain	ID=PRO_0000167870;Note=Electron transfer flavoprotein subunit beta
ETFB	P38117	72	125	123	134	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:1T9G,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15159392,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15159392,PMID:15975918,PMID:8962055
ETFB	P38117	72	125	71	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFB	P38117	72	125	84	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFB	P38117	72	125	93	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFB	P38117	72	125	101	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETFB	P38117	72	125	118	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV
ETS1	P14921	243	330	1	441	Chain	ID=PRO_0000204069;Note=Protein C-ets-1
ETS1	P14921	67	134	1	441	Chain	ID=PRO_0000204069;Note=Protein C-ets-1
ETS1	P14921	67	134	51	136	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ETS1	P14921	243	330	130	243	Region	Note=Activation domain%3B required for transcription activation
ETS1	P14921	67	134	130	243	Region	Note=Activation domain%3B required for transcription activation
ETS1	P14921	243	330	251	251	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETS1	P14921	243	330	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27577
ETS1	P14921	243	330	265	265	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETS1	P14921	243	330	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ETS1	P14921	243	330	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
ETS1	P14921	243	330	282	282	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27577
ETS1	P14921	243	330	285	285	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
ETS1	P14921	243	330	305	305	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ETS1	P14921	243	330	28	243	Alternative sequence	ID=VSP_046056;Note=In isoform Ets-1 p27. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19377509;Dbxref=PMID:19377509
ETS1	P14921	67	134	28	243	Alternative sequence	ID=VSP_046056;Note=In isoform Ets-1 p27. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19377509;Dbxref=PMID:19377509
ETS1	P14921	243	330	244	330	Alternative sequence	ID=VSP_001464;Note=In isoform c-ETS-1B. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ETS1	P14921	243	330	262	272	Alternative sequence	ID=VSP_055485;Note=In isoform 5. DRLTQSWSSQS->GQEMGKEEKQT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETS1	P14921	243	330	273	441	Alternative sequence	ID=VSP_055486;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ETS1	P14921	243	330	236	243	Sequence conflict	Note=MCMGRTSR->FLPPPLPP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ETS1	P14921	243	330	255	255	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ETS1	P14921	243	330	304	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GVJ
ETS1	P14921	243	330	323	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GVJ
ETV6	P41212	54	109	1	452	Chain	ID=PRO_0000204121;Note=Transcription factor ETV6
ETV6	P41212	109	154	1	452	Chain	ID=PRO_0000204121;Note=Transcription factor ETV6
ETV6	P41212	154	336	1	452	Chain	ID=PRO_0000204121;Note=Transcription factor ETV6
ETV6	P41212	54	109	40	124	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ETV6	P41212	109	154	40	124	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
ETV6	P41212	54	109	54	55	Site	Note=Breakpoint for translocation to form ETV6-MDS2 in MDS
ETV6	P41212	54	109	55	56	Site	Note=Breakpoint for translocation to form PAX5-ETV6
ETV6	P41212	154	336	336	337	Site	Note=Breakpoint for translocation to form ETV6-AML1 in ALL
ETV6	P41212	154	336	213	213	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
ETV6	P41212	154	336	238	238	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97360
ETV6	P41212	154	336	257	257	Modified residue	Note=Phosphoserine%3B by MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12435397;Dbxref=PMID:12435397
ETV6	P41212	154	336	302	302	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ETV6	P41212	154	336	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97360
ETV6	P41212	154	336	288	288	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
ETV6	P41212	154	336	302	302	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ETV6	P41212	154	336	214	214	Natural variant	ID=VAR_073322;Note=In THC5%3B abrogates DNA binding%3B alters subcellular location%3B decreases transcriptional repression in a dominant-negative fashion. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25581430;Dbxref=dbSNP:rs724159947,PMID:25581430
ETV6	P41212	154	336	213	213	Mutagenesis	Note=No effect. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12435397;Dbxref=PMID:12435397
ETV6	P41212	154	336	238	238	Mutagenesis	Note=No effect. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12435397;Dbxref=PMID:12435397
ETV6	P41212	154	336	257	257	Mutagenesis	Note=No phosphorylation by MAPK14. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12435397;Dbxref=PMID:12435397
ETV6	P41212	54	109	52	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	54	109	58	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	54	109	63	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	54	109	84	87	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	54	109	91	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	54	109	99	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	54	109	107	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	109	154	107	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
ETV6	P41212	109	154	110	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JI7
EVI5L	Q96CN4	184	209	1	794	Chain	ID=PRO_0000263097;Note=EVI5-like protein
EVI5L	Q96CN4	251	299	1	794	Chain	ID=PRO_0000263097;Note=EVI5-like protein
EVI5L	Q96CN4	299	329	1	794	Chain	ID=PRO_0000263097;Note=EVI5-like protein
EVI5L	Q96CN4	184	209	115	300	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
EVI5L	Q96CN4	251	299	115	300	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
EVI5L	Q96CN4	299	329	115	300	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
EVI5L	Q96CN4	184	209	197	197	Site	Note=Glutamine finger;Ontology_term=ECO:0000250;evidence=ECO:0000250
EVL	Q9UI08	342	362	1	416	Chain	ID=PRO_0000087104;Note=Ena/VASP-like protein
EVL	Q9UI08	342	362	222	413	Region	Note=EVH2
EVL	Q9UI08	342	362	342	362	Region	Note=Required for interaction with ZDHHC17;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28882895;Dbxref=PMID:28882895
EVL	Q9UI08	342	362	349	349	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19367720,PMID:24275569
EVL	Q9UI08	342	362	354	354	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
EVL	Q9UI08	342	362	342	362	Alternative sequence	ID=VSP_058778;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.19
EXOSC2	Q13868	90	120	1	293	Chain	ID=PRO_0000087129;Note=Exosome complex component RRP4
EXOSC2	Q13868	90	120	79	159	Domain	Note=S1 motif
EXOSC2	Q13868	90	120	91	120	Alternative sequence	ID=VSP_057568;Note=In isoform 3. Missing
EXOSC2	Q13868	90	120	86	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC2	Q13868	90	120	95	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC2	Q13868	90	120	101	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC2	Q13868	90	120	106	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
FOXJ2	Q9P0K8	111	136	2	574	Chain	ID=PRO_0000091853;Note=Forkhead box protein J2
FOXJ2	Q9P0K8	136	159	2	574	Chain	ID=PRO_0000091853;Note=Forkhead box protein J2
FOXJ2	Q9P0K8	272	408	2	574	Chain	ID=PRO_0000091853;Note=Forkhead box protein J2
FOXJ2	Q9P0K8	442	512	2	574	Chain	ID=PRO_0000091853;Note=Forkhead box protein J2
FOXJ2	Q9P0K8	111	136	66	143	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ2	Q9P0K8	136	159	66	143	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ2	Q9P0K8	272	408	291	294	Compositional bias	Note=Poly-Gln
FOXJ2	Q9P0K8	272	408	295	298	Compositional bias	Note=Poly-Pro
FOXJ2	Q9P0K8	272	408	299	306	Compositional bias	Note=Poly-Gln
FOXJ2	Q9P0K8	272	408	313	321	Compositional bias	Note=Poly-Gln
FOXJ2	Q9P0K8	272	408	390	395	Compositional bias	Note=Poly-Pro
FOXJ2	Q9P0K8	272	408	310	310	Natural variant	ID=VAR_021842;Note=P->S;Dbxref=dbSNP:rs2277415
FOXJ3	Q9UPW0	450	484	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	210	253	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	176	210	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	148	176	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	123	148	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	450	484	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	210	253	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	176	210	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	148	176	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	123	148	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	450	484	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	210	253	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	176	210	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	148	176	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	123	148	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	450	484	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	210	253	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	176	210	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	148	176	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	123	148	1	622	Chain	ID=PRO_0000091855;Note=Forkhead box protein J3
FOXJ3	Q9UPW0	148	176	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	123	148	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	148	176	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	123	148	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	148	176	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	123	148	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	148	176	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	123	148	77	168	DNA binding	Note=Fork-head;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00089
FOXJ3	Q9UPW0	210	253	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
FOXJ3	Q9UPW0	210	253	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
FOXJ3	Q9UPW0	210	253	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
FOXJ3	Q9UPW0	210	253	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
FOXJ3	Q9UPW0	210	253	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	176	210	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	210	253	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	176	210	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	210	253	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	176	210	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	210	253	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	176	210	177	210	Alternative sequence	ID=VSP_010367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FOXJ3	Q9UPW0	148	176	162	162	Natural variant	ID=VAR_039104;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs343376,PMID:10470851,PMID:15489334
FOXJ3	Q9UPW0	148	176	162	162	Natural variant	ID=VAR_039104;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs343376,PMID:10470851,PMID:15489334
FOXJ3	Q9UPW0	148	176	162	162	Natural variant	ID=VAR_039104;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs343376,PMID:10470851,PMID:15489334
FOXJ3	Q9UPW0	148	176	162	162	Natural variant	ID=VAR_039104;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs343376,PMID:10470851,PMID:15489334
HELZ2	Q9BYK8	2132	2176	1	2649	Chain	ID=PRO_0000058561;Note=Helicase with zinc finger domain 2
HELZ2	Q9BYK8	2132	2176	2174	2181	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
HELZ2	Q9BYK8	2132	2176	2135	2649	Region	Note=Interaction with THRAP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23525231;Dbxref=PMID:23525231
HELZ2	Q9BYK8	2132	2176	2170	2170	Natural variant	ID=VAR_047043;Note=T->M;Dbxref=dbSNP:rs3810481
HELZ	P42694	692	725	1	1942	Chain	ID=PRO_0000089185;Note=Probable helicase with zinc finger domain
FRMD4B	Q9Y2L6	571	590	1	1034	Chain	ID=PRO_0000219446;Note=FERM domain-containing protein 4B
FRMD4B	Q9Y2L6	263	292	1	1034	Chain	ID=PRO_0000219446;Note=FERM domain-containing protein 4B
FRMD4B	Q9Y2L6	222	243	1	1034	Chain	ID=PRO_0000219446;Note=FERM domain-containing protein 4B
FRMD4B	Q9Y2L6	108	138	1	1034	Chain	ID=PRO_0000219446;Note=FERM domain-containing protein 4B
FRMD4B	Q9Y2L6	263	292	59	361	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD4B	Q9Y2L6	222	243	59	361	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD4B	Q9Y2L6	108	138	59	361	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMD4B	Q9Y2L6	571	590	542	971	Region	Note=Necessary for adherens junction and tight junction localization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q920B0
FRMPD2	Q68DX3	103	125	1	1309	Chain	ID=PRO_0000306854;Note=FERM and PDZ domain-containing protein 2
FRMPD2	Q68DX3	103	125	15	197	Domain	Note=KIND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00709
FRMPD2	Q68DX3	103	125	1	1048	Alternative sequence	ID=VSP_028521;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
FRMPD2	Q68DX3	103	125	1	989	Alternative sequence	ID=VSP_028522;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FRMPD2	Q68DX3	103	125	103	124	Alternative sequence	ID=VSP_028524;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FRMPD3	Q5JV73	167	203	1	1810	Chain	ID=PRO_0000254650;Note=FERM and PDZ domain-containing protein 3
FRMPD3	Q5JV73	375	405	1	1810	Chain	ID=PRO_0000254650;Note=FERM and PDZ domain-containing protein 3
FRMPD3	Q5JV73	167	203	180	494	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FRMPD3	Q5JV73	375	405	180	494	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
FST	P19883	165	240	30	344	Chain	ID=PRO_0000010103;Note=Follistatin
FST	P19883	165	240	112	166	Domain	Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FST	P19883	165	240	167	190	Domain	Note=Follistatin-like 2
FST	P19883	165	240	186	241	Domain	Note=Kazal-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
FST	P19883	165	240	168	179	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2B0U,ECO:0000244|PDB:2P6A,ECO:0000244|PDB:3HH2,ECO:0000244|PDB:5JHW,ECO:0000269|PubMed:16198295,ECO:0000269|PubMed:17409095,ECO:0000269|PubMed:19644449,ECO:0000269|PubMed:28257634;Dbxref=PMID:16198295,PMID:17409095,PMID:19644449,PMID:28257634
FST	P19883	165	240	173	189	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2B0U,ECO:0000244|PDB:2P6A,ECO:0000244|PDB:3HH2,ECO:0000244|PDB:5JHW,ECO:0000269|PubMed:16198295,ECO:0000269|PubMed:17409095,ECO:0000269|PubMed:19644449,ECO:0000269|PubMed:28257634;Dbxref=PMID:16198295,PMID:17409095,PMID:19644449,PMID:28257634
FST	P19883	165	240	192	225	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2B0U,ECO:0000244|PDB:2P6A,ECO:0000244|PDB:3HH2,ECO:0000244|PDB:5JHW,ECO:0000269|PubMed:16198295,ECO:0000269|PubMed:17409095,ECO:0000269|PubMed:19644449,ECO:0000269|PubMed:28257634;Dbxref=PMID:16198295,PMID:17409095,PMID:19644449,PMID:28257634
FST	P19883	165	240	196	218	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2B0U,ECO:0000244|PDB:2P6A,ECO:0000244|PDB:3HH2,ECO:0000244|PDB:5JHW,ECO:0000269|PubMed:16198295,ECO:0000269|PubMed:17409095,ECO:0000269|PubMed:19644449,ECO:0000269|PubMed:28257634;Dbxref=PMID:16198295,PMID:17409095,PMID:19644449,PMID:28257634
FST	P19883	165	240	207	239	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2B0U,ECO:0000244|PDB:2P6A,ECO:0000244|PDB:3HH2,ECO:0000244|PDB:5JHW,ECO:0000269|PubMed:16198295,ECO:0000269|PubMed:17409095,ECO:0000269|PubMed:19644449,ECO:0000269|PubMed:28257634;Dbxref=PMID:16198295,PMID:17409095,PMID:19644449,PMID:28257634
FST	P19883	165	240	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
FST	P19883	165	240	178	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
FST	P19883	165	240	185	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
FST	P19883	165	240	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B0U
FST	P19883	165	240	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
FST	P19883	165	240	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
FST	P19883	165	240	217	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
FST	P19883	165	240	233	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HH2
ALAD	P13716	132	160	1	330	Chain	ID=PRO_0000140526;Note=Delta-aminolevulinic acid dehydratase
ALAD	P13716	38	54	1	330	Chain	ID=PRO_0000140526;Note=Delta-aminolevulinic acid dehydratase
ALAD	P13716	132	160	132	132	Metal binding	Note=Zinc 1%3B catalytic
ALAD	P13716	38	54	1	38	Alternative sequence	ID=VSP_037866;Note=In isoform 2. MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVT->MPPTSSTPSLSRPGLGQAGKPDTGSHPPPTISTSIFLSCFPTIPLSRPRTTGPSHSYQSISHPRSCR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALAD	P13716	132	160	133	133	Natural variant	ID=VAR_003634;Note=In AHEPP%3B mixture of about 50%25 hexamer and 50%25 octamer%3B about 10%25 residual activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17236137,ECO:0000269|PubMed:2063868;Dbxref=dbSNP:rs121912980,PMID:17236137,PMID:2063868
ALAD	P13716	132	160	153	153	Natural variant	ID=VAR_020974;Note=In AHEPP%3B about 95%25 octamer%3B about 40%25 residual activity. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706561,ECO:0000269|PubMed:17236137;Dbxref=PMID:10706561,PMID:17236137
ALAD	P13716	132	160	132	132	Mutagenesis	Note=Reduces enzyme activity about 1000000-fold%3B when associated with A-122 and A-124. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11032836;Dbxref=PMID:11032836
ALAD	P13716	38	54	44	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PV8
ALAD	P13716	38	54	48	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PV8
ALAD	P13716	38	54	54	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PV8
ALAD	P13716	132	160	131	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HNR
ALAD	P13716	132	160	137	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HMS
ALAD	P13716	132	160	141	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PV8
FUOM	A2VDF0	75	108	1	154	Chain	ID=PRO_0000286553;Note=Fucose mutarotase
FUOM	A2VDF0	75	108	79	79	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
FUOM	A2VDF0	75	108	81	81	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FUBP3	Q96I24	451	477	2	572	Chain	ID=PRO_0000050140;Note=Far upstream element-binding protein 3
FUBP3	Q96I24	503	527	2	572	Chain	ID=PRO_0000050140;Note=Far upstream element-binding protein 3
FUBP3	Q96I24	451	477	298	548	Alternative sequence	ID=VSP_008324;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FUBP3	Q96I24	503	527	298	548	Alternative sequence	ID=VSP_008324;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FUK	Q8N0W3	78	95	1	1084	Chain	ID=PRO_0000156672;Note=L-fucose kinase
FUK	Q8N0W3	194	221	1	1084	Chain	ID=PRO_0000156672;Note=L-fucose kinase
FUK	Q8N0W3	390	447	1	1084	Chain	ID=PRO_0000156672;Note=L-fucose kinase
FUK	Q8N0W3	78	95	78	78	Alternative sequence	ID=VSP_015422;Note=In isoform 2. T->TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FUK	Q8N0W3	390	447	400	400	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HECTD3	Q5T447	615	645	2	861	Chain	ID=PRO_0000241445;Note=E3 ubiquitin-protein ligase HECTD3
HECTD3	Q5T447	615	645	512	857	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
FER1L6	Q2WGJ9	671	711	1	1857	Chain	ID=PRO_0000323674;Note=Fer-1-like protein 6
FER1L6	Q2WGJ9	1407	1463	1	1857	Chain	ID=PRO_0000323674;Note=Fer-1-like protein 6
FER1L6	Q2WGJ9	671	711	1	1824	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FER1L6	Q2WGJ9	1407	1463	1	1824	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FER1L6	Q2WGJ9	1407	1463	1343	1441	Domain	Note=C2 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
FUBP1	Q96AE4	114	138	2	644	Chain	ID=PRO_0000050135;Note=Far upstream element-binding protein 1
FUBP1	Q96AE4	114	138	100	164	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
FUBP1	Q96AE4	114	138	112	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ
FUBP1	Q96AE4	114	138	118	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ
FUBP1	Q96AE4	114	138	121	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ
FUBP1	Q96AE4	114	138	133	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ
FUS	P35637	355	389	1	526	Chain	ID=PRO_0000081591;Note=RNA-binding protein FUS
FUS	P35637	355	389	285	371	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
FUS	P35637	355	389	371	526	Compositional bias	Note=Arg/Gly-rich
FUS	P35637	355	389	377	377	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12964758;Dbxref=PMID:12964758
FUS	P35637	355	389	383	383	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12964758;Dbxref=PMID:12964758
FUS	P35637	355	389	386	386	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12964758;Dbxref=PMID:12964758
FUS	P35637	355	389	388	388	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12964758;Dbxref=PMID:12964758
FUS	P35637	355	389	358	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LA6
FUS	P35637	355	389	365	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LA6
FUS	P35637	355	389	379	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCW
FYN	P06241	424	468	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	232	287	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	182	232	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	115	147	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	424	468	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	232	287	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	182	232	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	115	147	2	537	Chain	ID=PRO_0000088099;Note=Tyrosine-protein kinase Fyn
FYN	P06241	115	147	82	143	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FYN	P06241	115	147	82	143	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
FYN	P06241	232	287	149	246	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
FYN	P06241	182	232	149	246	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
FYN	P06241	232	287	149	246	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
FYN	P06241	182	232	149	246	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
FYN	P06241	424	468	271	524	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FYN	P06241	232	287	271	524	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FYN	P06241	424	468	271	524	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FYN	P06241	232	287	271	524	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FYN	P06241	232	287	277	285	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FYN	P06241	232	287	277	285	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FYN	P06241	182	232	185	185	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39688
FYN	P06241	182	232	185	185	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39688
FYN	P06241	232	287	233	287	Alternative sequence	ID=VSP_024108;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FYN	P06241	232	287	233	287	Alternative sequence	ID=VSP_024108;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FYN	P06241	232	287	234	287	Alternative sequence	ID=VSP_024110;Note=In isoform 2. RAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWM->KADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7822789;Dbxref=PMID:7822789
FYN	P06241	232	287	234	287	Alternative sequence	ID=VSP_024110;Note=In isoform 2. RAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWM->KADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7822789;Dbxref=PMID:7822789
FYN	P06241	232	287	243	243	Natural variant	ID=VAR_041704;Note=In a lung squamous cell carcinoma sample%3B somatic mutation. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
FYN	P06241	232	287	243	243	Natural variant	ID=VAR_041704;Note=In a lung squamous cell carcinoma sample%3B somatic mutation. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
FYN	P06241	424	468	445	445	Natural variant	ID=VAR_014661;Note=I->F;Dbxref=dbSNP:rs1801121
FYN	P06241	424	468	445	445	Natural variant	ID=VAR_014661;Note=I->F;Dbxref=dbSNP:rs1801121
FYN	P06241	182	232	184	184	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FYN	P06241	182	232	184	184	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
FYN	P06241	424	468	437	437	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FYN	P06241	424	468	437	437	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FYN	P06241	424	468	437	437	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FYN	P06241	424	468	437	437	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FYN	P06241	115	147	115	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	115	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	125	127	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	125	127	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	130	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	130	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	135	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	135	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	138	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	138	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UA7
FYN	P06241	115	147	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G83
FYN	P06241	115	147	144	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G83
FYN	P06241	115	147	147	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G83
FYN	P06241	115	147	147	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G83
FYN	P06241	182	232	185	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	185	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	194	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	194	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	197	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	197	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	209	211	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AOT
FYN	P06241	182	232	209	211	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AOT
FYN	P06241	182	232	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	232	287	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	232	287	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	182	232	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	232	287	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	232	287	238	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U1P
FYN	P06241	232	287	263	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	263	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	268	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	268	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	271	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	271	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	285	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	232	287	285	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	424	468	430	432	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	424	468	430	432	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	424	468	435	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	424	468	435	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	424	468	445	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FYN	P06241	424	468	445	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DQ7
FXYD3	Q14802	13	24	1	20	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17077088;Dbxref=PMID:17077088
FXYD3	Q14802	13	24	1	20	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17077088;Dbxref=PMID:17077088
FXYD3	Q14802	13	24	1	20	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17077088;Dbxref=PMID:17077088
FXYD3	Q14802	13	24	21	87	Chain	ID=PRO_0000010362;Note=FXYD domain-containing ion transport regulator 3
FXYD3	Q14802	32	57	21	87	Chain	ID=PRO_0000010362;Note=FXYD domain-containing ion transport regulator 3
FXYD3	Q14802	13	24	21	87	Chain	ID=PRO_0000010362;Note=FXYD domain-containing ion transport regulator 3
FXYD3	Q14802	32	57	21	87	Chain	ID=PRO_0000010362;Note=FXYD domain-containing ion transport regulator 3
FXYD3	Q14802	13	24	21	87	Chain	ID=PRO_0000010362;Note=FXYD domain-containing ion transport regulator 3
FXYD3	Q14802	32	57	21	87	Chain	ID=PRO_0000010362;Note=FXYD domain-containing ion transport regulator 3
FXYD3	Q14802	13	24	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	13	24	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	13	24	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	39	59	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	39	59	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	39	59	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD3	Q14802	32	57	33	87	Alternative sequence	ID=VSP_047286;Note=In isoform 5. DWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS->GESPCPLSPPHNPTYCLVPRVPIQGWGLT;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD3	Q14802	32	57	33	87	Alternative sequence	ID=VSP_047286;Note=In isoform 5. DWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS->GESPCPLSPPHNPTYCLVPRVPIQGWGLT;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD3	Q14802	32	57	33	87	Alternative sequence	ID=VSP_047286;Note=In isoform 5. DWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS->GESPCPLSPPHNPTYCLVPRVPIQGWGLT;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD3	Q14802	32	57	40	40	Natural variant	ID=VAR_049109;Note=G->S;Dbxref=dbSNP:rs35578165
FXYD3	Q14802	32	57	40	40	Natural variant	ID=VAR_049109;Note=G->S;Dbxref=dbSNP:rs35578165
FXYD3	Q14802	32	57	40	40	Natural variant	ID=VAR_049109;Note=G->S;Dbxref=dbSNP:rs35578165
FXYD3	Q14802	32	57	44	44	Mutagenesis	Note=Abolishes glutathionylation but does not affect interaction with ATP1B1%3B when associated with S-49%3B S-61 and S-63. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454534;Dbxref=PMID:21454534
FXYD3	Q14802	32	57	44	44	Mutagenesis	Note=Abolishes glutathionylation but does not affect interaction with ATP1B1%3B when associated with S-49%3B S-61 and S-63. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454534;Dbxref=PMID:21454534
FXYD3	Q14802	32	57	44	44	Mutagenesis	Note=Abolishes glutathionylation but does not affect interaction with ATP1B1%3B when associated with S-49%3B S-61 and S-63. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454534;Dbxref=PMID:21454534
FXYD3	Q14802	32	57	49	49	Mutagenesis	Note=Abolishes glutathionylation but does not affect interaction with ATP1B1%3B when associated with S-43%3B S-61 and S-63. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454534;Dbxref=PMID:21454534
FXYD3	Q14802	32	57	49	49	Mutagenesis	Note=Abolishes glutathionylation but does not affect interaction with ATP1B1%3B when associated with S-43%3B S-61 and S-63. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454534;Dbxref=PMID:21454534
FXYD3	Q14802	32	57	49	49	Mutagenesis	Note=Abolishes glutathionylation but does not affect interaction with ATP1B1%3B when associated with S-43%3B S-61 and S-63. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454534;Dbxref=PMID:21454534
FXYD3	Q14802	32	57	36	37	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD3	Q14802	32	57	36	37	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD3	Q14802	32	57	36	37	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROS	P10746	131	158	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	106	131	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	81	106	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	21	49	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	131	158	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	106	131	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	81	106	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	21	49	1	265	Chain	ID=PRO_0000135251;Note=Uroporphyrinogen-III synthase
UROS	P10746	21	49	47	47	Natural variant	ID=VAR_021616;Note=In CEP%3B severe cutaneous lesions%3B less than 3%25 wild-type activity. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15304101;Dbxref=dbSNP:rs397515527,PMID:15304101
UROS	P10746	21	49	47	47	Natural variant	ID=VAR_021616;Note=In CEP%3B severe cutaneous lesions%3B less than 3%25 wild-type activity. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15304101;Dbxref=dbSNP:rs397515527,PMID:15304101
UROS	P10746	81	106	82	82	Natural variant	ID=VAR_003680;Note=In CEP%3B mild phenotype%3B high residual activity. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7860775;Dbxref=dbSNP:rs121908016,PMID:7860775
UROS	P10746	81	106	82	82	Natural variant	ID=VAR_003680;Note=In CEP%3B mild phenotype%3B high residual activity. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7860775;Dbxref=dbSNP:rs121908016,PMID:7860775
UROS	P10746	81	106	99	99	Natural variant	ID=VAR_003681;Note=In CEP. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7860775;Dbxref=PMID:7860775
UROS	P10746	81	106	99	99	Natural variant	ID=VAR_003681;Note=In CEP. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7860775;Dbxref=PMID:7860775
UROS	P10746	81	106	104	104	Natural variant	ID=VAR_003682;Note=In CEP%3B residual activity. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7860775;Dbxref=dbSNP:rs397515528,PMID:7860775
UROS	P10746	81	106	104	104	Natural variant	ID=VAR_003682;Note=In CEP%3B residual activity. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7860775;Dbxref=dbSNP:rs397515528,PMID:7860775
UROS	P10746	106	131	124	124	Natural variant	ID=VAR_049345;Note=K->R;Dbxref=dbSNP:rs17153561
UROS	P10746	106	131	124	124	Natural variant	ID=VAR_049345;Note=K->R;Dbxref=dbSNP:rs17153561
UROS	P10746	106	131	129	129	Natural variant	ID=VAR_021618;Note=In CEP%3B no residual activity. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11121156;Dbxref=PMID:11121156
UROS	P10746	106	131	129	129	Natural variant	ID=VAR_021618;Note=In CEP%3B no residual activity. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11121156;Dbxref=PMID:11121156
UROS	P10746	81	106	103	103	Mutagenesis	Note=Slightly affects enzymatic activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11689424;Dbxref=PMID:11689424
UROS	P10746	81	106	103	103	Mutagenesis	Note=Slightly affects enzymatic activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11689424;Dbxref=PMID:11689424
UROS	P10746	106	131	127	127	Mutagenesis	Note=Does not affect enzymatic activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11689424;Dbxref=PMID:11689424
UROS	P10746	106	131	127	127	Mutagenesis	Note=Does not affect enzymatic activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11689424;Dbxref=PMID:11689424
UROS	P10746	21	49	18	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	18	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	25	27	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	25	27	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	29	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	29	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	36	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	36	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	43	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	21	49	43	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	80	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	80	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	88	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	88	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	106	131	101	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	101	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	106	131	101	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	81	106	101	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	106	131	122	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	106	131	122	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	146	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	151	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	151	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
UROS	P10746	131	158	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JR2
GALNT2	Q10471	480	520	1	571	Chain	ID=PRO_0000223391;Note=Polypeptide N-acetylgalactosaminyltransferase 2
GALNT2	Q10471	480	520	52	571	Chain	ID=PRO_0000012265;Note=Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
GALNT2	Q10471	480	520	25	571	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT2	Q10471	480	520	443	566	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT2	Q10471	480	520	516	516	Site	Note=Not glycosylated
GALNT2	Q10471	480	520	496	513	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00174,ECO:0000269|PubMed:16434399;Dbxref=PMID:16434399
GALNT2	Q10471	480	520	356	571	Alternative sequence	ID=VSP_056493;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GALNT2	Q10471	480	520	478	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AJO
GALNT2	Q10471	480	520	482	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AJO
GALNT2	Q10471	480	520	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AJO
GALNT2	Q10471	480	520	495	498	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AJO
GALNT2	Q10471	480	520	509	512	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AJO
GALNT2	Q10471	480	520	518	520	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AJO
GABRA2	P47869	234	285	29	451	Chain	ID=PRO_0000000433;Note=Gamma-aminobutyric acid receptor subunit alpha-2
GABRA2	P47869	234	285	29	451	Chain	ID=PRO_0000000433;Note=Gamma-aminobutyric acid receptor subunit alpha-2
GABRA2	P47869	234	285	29	451	Chain	ID=PRO_0000000433;Note=Gamma-aminobutyric acid receptor subunit alpha-2
GABRA2	P47869	234	285	29	451	Chain	ID=PRO_0000000433;Note=Gamma-aminobutyric acid receptor subunit alpha-2
GABRA2	P47869	234	285	29	251	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	29	251	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	29	251	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	29	251	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	252	273	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	252	273	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	252	273	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	252	273	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	279	300	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	279	300	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	279	300	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA2	P47869	234	285	279	300	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA4	P48169	240	291	36	554	Chain	ID=PRO_0000000441;Note=Gamma-aminobutyric acid receptor subunit alpha-4
GABRA4	P48169	240	291	36	258	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA4	P48169	240	291	259	280	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRA4	P48169	240	291	285	306	Transmembrane	Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABRP	O00591	226	277	17	440	Chain	ID=PRO_0000000492;Note=Gamma-aminobutyric acid receptor subunit pi
GABRP	O00591	226	277	17	440	Chain	ID=PRO_0000000492;Note=Gamma-aminobutyric acid receptor subunit pi
GABRP	O00591	226	277	17	242	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	17	242	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	243	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	243	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	270	292	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	270	292	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	228	228	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABRP	O00591	226	277	228	228	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	1	605	Chain	ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5
GDPD5	Q8WTR4	125	158	1	605	Chain	ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5
GDPD5	Q8WTR4	316	389	1	605	Chain	ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5
GDPD5	Q8WTR4	125	158	1	605	Chain	ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5
GDPD5	Q8WTR4	125	158	111	125	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	125	158	111	125	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	125	158	126	146	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	125	158	126	146	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	125	158	147	160	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	125	158	147	160	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	214	496	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	214	496	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	228	485	Domain	Note=GP-PDE
GDPD5	Q8WTR4	316	389	228	485	Domain	Note=GP-PDE
GDPD5	Q8WTR4	316	389	336	336	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	336	336	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	352	352	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	352	352	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	374	374	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	374	374	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GDPD5	Q8WTR4	316	389	25	571	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GDPD5	Q8WTR4	125	158	25	571	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GDPD5	Q8WTR4	316	389	25	571	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GDPD5	Q8WTR4	125	158	25	571	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
GDPD5	Q8WTR4	125	158	1	245	Alternative sequence	ID=VSP_020813;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GDPD5	Q8WTR4	125	158	1	245	Alternative sequence	ID=VSP_020813;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GDPD5	Q8WTR4	125	158	1	218	Alternative sequence	ID=VSP_020814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GDPD5	Q8WTR4	125	158	1	218	Alternative sequence	ID=VSP_020814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GDPD5	Q8WTR4	125	158	1	138	Alternative sequence	ID=VSP_020815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GDPD5	Q8WTR4	125	158	1	138	Alternative sequence	ID=VSP_020815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GDPD5	Q8WTR4	125	158	40	158	Alternative sequence	ID=VSP_020816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
GDPD5	Q8WTR4	125	158	40	158	Alternative sequence	ID=VSP_020816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
GMNN	O75496	119	156	1	209	Chain	ID=PRO_0000148729;Note=Geminin
GMNN	O75496	119	156	1	209	Chain	ID=PRO_0000148729;Note=Geminin
GMNN	O75496	119	156	82	161	Region	Note=Necessary and sufficient for interaction with IDAS and CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21543332;Dbxref=PMID:21543332
GMNN	O75496	119	156	82	161	Region	Note=Necessary and sufficient for interaction with IDAS and CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21543332;Dbxref=PMID:21543332
GMNN	O75496	119	156	94	144	Coiled coil	Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15260975,ECO:0000269|PubMed:15313623,ECO:0000269|PubMed:15378034,ECO:0000269|PubMed:24064211;Dbxref=PMID:15260975,PMID:15313623,PMID:15378034,PMID:24064211
GMNN	O75496	119	156	94	144	Coiled coil	Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15260975,ECO:0000269|PubMed:15313623,ECO:0000269|PubMed:15378034,ECO:0000269|PubMed:24064211;Dbxref=PMID:15260975,PMID:15313623,PMID:15378034,PMID:24064211
GMNN	O75496	119	156	110	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T6F
GMNN	O75496	119	156	110	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T6F
GFRA2	O00451	13	118	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
GFRA2	O00451	406	424	22	444	Chain	ID=PRO_0000010785;Note=GDNF family receptor alpha-2
GFRA2	O00451	13	118	22	444	Chain	ID=PRO_0000010785;Note=GDNF family receptor alpha-2
GFRA2	O00451	406	424	22	444	Chain	ID=PRO_0000010785;Note=GDNF family receptor alpha-2
GFRA2	O00451	13	118	52	52	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GFRA2	O00451	406	424	413	413	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GFRA2	O00451	406	424	413	413	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GFRA2	O00451	13	118	14	146	Alternative sequence	ID=VSP_001661;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9182803,ECO:0000303|Ref.4;Dbxref=PMID:9182803
GFRA2	O00451	13	118	14	118	Alternative sequence	ID=VSP_046112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GFRA2	O00451	13	118	40	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR4
GFRA2	O00451	13	118	51	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR4
GFRA2	O00451	13	118	76	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR4
GFRA2	O00451	13	118	89	92	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR4
GFRA2	O00451	13	118	102	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR4
GFPT1	Q06210	575	631	2	699	Chain	ID=PRO_0000135280;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
GFPT1	Q06210	336	368	2	699	Chain	ID=PRO_0000135280;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
GFPT1	Q06210	228	246	2	699	Chain	ID=PRO_0000135280;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
GFPT1	Q06210	74	116	2	699	Chain	ID=PRO_0000135280;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
GFPT1	Q06210	38	74	2	699	Chain	ID=PRO_0000135280;Note=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
GFPT1	Q06210	228	246	2	305	Domain	Note=Glutamine amidotransferase type-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00609
GFPT1	Q06210	74	116	2	305	Domain	Note=Glutamine amidotransferase type-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00609
GFPT1	Q06210	38	74	2	305	Domain	Note=Glutamine amidotransferase type-2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00609
GFPT1	Q06210	575	631	548	689	Domain	Note=SIS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00797
GFPT1	Q06210	575	631	313	680	Region	Note=Isomerase
GFPT1	Q06210	336	368	313	680	Region	Note=Isomerase
GFPT1	Q06210	575	631	595	595	Binding site	Note=Substrate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2V4M,ECO:0000244|PDB:2ZJ3,ECO:0000244|PDB:2ZJ4,ECO:0000269|PubMed:19059404;Dbxref=PMID:19059404
GFPT1	Q06210	74	116	103	103	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GFPT1	Q06210	228	246	229	246	Alternative sequence	ID=VSP_007497;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1460020,ECO:0000303|PubMed:15489334;Dbxref=PMID:1460020,PMID:15489334
GFPT1	Q06210	38	74	43	43	Natural variant	ID=VAR_065341;Note=In CMS12. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21310273;Dbxref=PMID:21310273
GFPT1	Q06210	74	116	111	111	Natural variant	ID=VAR_065342;Note=In CMS12. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21310273;Dbxref=dbSNP:rs201322234,PMID:21310273
GFPT1	Q06210	336	368	366	366	Natural variant	ID=VAR_065345;Note=In CMS12. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21310273;Dbxref=PMID:21310273
GFPT1	Q06210	336	368	339	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	336	368	342	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	336	368	350	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	336	368	359	361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	336	368	364	367	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	575	631	567	581	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	575	631	584	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	575	631	590	595	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	575	631	597	600	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	575	631	602	605	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4M
GFPT1	Q06210	575	631	607	611	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GFPT1	Q06210	575	631	617	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZJ3
GAB2	Q9UQC2	587	629	1	676	Chain	ID=PRO_0000050285;Note=GRB2-associated-binding protein 2
GAB2	Q9UQC2	587	629	622	622	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738
GAB2	Q9UQC2	587	629	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738
GAB3	Q8WWW8	509	548	1	586	Chain	ID=PRO_0000318939;Note=GRB2-associated-binding protein 3
GAB3	Q8WWW8	509	548	510	548	Alternative sequence	ID=VSP_055259;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GABBR2	O75899	432	459	42	941	Chain	ID=PRO_0000012952;Note=Gamma-aminobutyric acid type B receptor subunit 2
GABBR2	O75899	333	412	42	941	Chain	ID=PRO_0000012952;Note=Gamma-aminobutyric acid type B receptor subunit 2
GABBR2	O75899	266	333	42	941	Chain	ID=PRO_0000012952;Note=Gamma-aminobutyric acid type B receptor subunit 2
GABBR2	O75899	244	266	42	941	Chain	ID=PRO_0000012952;Note=Gamma-aminobutyric acid type B receptor subunit 2
GABBR2	O75899	432	459	42	483	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABBR2	O75899	333	412	42	483	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABBR2	O75899	266	333	42	483	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABBR2	O75899	244	266	42	483	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABBR2	O75899	266	333	298	298	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GABBR2	O75899	333	412	389	389	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22660477;Dbxref=PMID:22660477
GABBR2	O75899	333	412	404	404	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22660477,ECO:0000269|PubMed:24305054;Dbxref=PMID:22660477,PMID:24305054
GABBR2	O75899	432	459	453	453	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22660477;Dbxref=PMID:22660477
GABBR2	O75899	266	333	237	266	Disulfide bond	.
GABBR2	O75899	244	266	237	266	Disulfide bond	.
GABBR2	O75899	266	333	265	302	Disulfide bond	.
GABBR2	O75899	244	266	265	302	Disulfide bond	.
GABBR2	O75899	244	266	237	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	244	266	250	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	266	333	257	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	244	266	257	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	266	333	278	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	266	333	287	290	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	266	333	304	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	266	333	315	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	333	412	335	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	333	412	346	348	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MR7
GABBR2	O75899	333	412	355	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	333	412	378	387	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	333	412	393	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	333	412	407	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	432	459	436	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	432	459	444	447	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	432	459	448	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	432	459	453	455	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GABBR2	O75899	432	459	459	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MS4
GALK2	Q01415	168	201	1	458	Chain	ID=PRO_0000184647;Note=N-acetylgalactosamine kinase
GALK2	Q01415	201	252	1	458	Chain	ID=PRO_0000184647;Note=N-acetylgalactosamine kinase
GALK2	Q01415	168	201	187	190	Region	Note=Substrate binding
GALK2	Q01415	168	201	190	190	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALK2	Q01415	168	201	182	182	Natural variant	ID=VAR_049123;Note=I->V;Dbxref=dbSNP:rs35507772
GALK2	Q01415	168	201	168	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	168	201	180	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	168	201	189	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	168	201	201	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	201	252	201	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	201	252	207	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	201	252	211	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	201	252	221	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	201	252	234	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GALK2	Q01415	201	252	239	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A2C
GARS	P41250	294	343	1	739	Chain	ID=PRO_0000072998;Note=Glycine--tRNA ligase
GARS	P41250	294	343	331	333	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19710017;Dbxref=PMID:19710017
GARS	P41250	294	343	341	346	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19710017;Dbxref=PMID:19710017
GARS	P41250	294	343	299	299	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19710017;Dbxref=PMID:19710017
GARS	P41250	294	343	294	294	Natural variant	ID=VAR_018720;Note=In CMT2D%3B shows a large reduction in aminoacylation activity%3B does not impair transcription or translation or protein stability%3B contrary to the wild-type protein%2C strongly interacts with NRP1. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12690580,ECO:0000269|PubMed:17035524,ECO:0000269|PubMed:25168514,ECO:0000269|PubMed:26503042;Dbxref=dbSNP:rs137852643,PMID:12690580,PMID:17035524,PMID:25168514,PMID:26503042
GARS	P41250	294	343	298	298	Natural variant	ID=VAR_073190;Note=In CMT2D%3B shows a large reduction in aminoacylation activity%3B demonstrates a change in subcellular location pattern%3B does not associate with granules. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20169446,ECO:0000269|PubMed:25168514;Dbxref=dbSNP:rs137852648,PMID:20169446,PMID:25168514
GARS	P41250	294	343	310	310	Natural variant	ID=VAR_079827;Note=Probable disease-associated mutation found in a patient with growth retardation%2C microcephaly%2C thinning of the corpus callosum%2C decreased white matter and brain stem involvement%2C as well as large calvaria%2C cerebellar vermis atrophy%2C dysmorphic features%2C prominent epicanthal folds%2C hypotelorism%2C high-arched palate%2C delayed motor milestones%2C apnea and sparse thin scalp hair%3B reduces to less than 1%25 aminoacylation activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28675565;Dbxref=dbSNP:rs1135401748,PMID:28675565
GARS	P41250	294	343	334	334	Natural variant	ID=VAR_073191;Note=In CMT2D%3B shows a large reduction in aminoacylation activity%3B demonstrates a change in subcellular location pattern%3B does not associate with granules%3B unknown pathological significance. I->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17101916,ECO:0000269|PubMed:24604904,ECO:0000269|PubMed:25168514;Dbxref=PMID:17101916,PMID:24604904,PMID:25168514
GARS	P41250	294	343	287	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZT5
GARS	P41250	294	343	298	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZXF
GARS	P41250	294	343	301	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZT5
GARS	P41250	294	343	308	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZT5
GARS	P41250	294	343	315	317	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZT5
GARS	P41250	294	343	321	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZT5
GARS	P41250	294	343	339	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZT5
GAS7	O60861	180	204	1	476	Chain	ID=PRO_0000076057;Note=Growth arrest-specific protein 7
GAS7	O60861	37	64	1	476	Chain	ID=PRO_0000076057;Note=Growth arrest-specific protein 7
GAS7	O60861	180	204	1	476	Chain	ID=PRO_0000076057;Note=Growth arrest-specific protein 7
GAS7	O60861	37	64	1	476	Chain	ID=PRO_0000076057;Note=Growth arrest-specific protein 7
GAS7	O60861	180	204	1	476	Chain	ID=PRO_0000076057;Note=Growth arrest-specific protein 7
GAS7	O60861	37	64	1	476	Chain	ID=PRO_0000076057;Note=Growth arrest-specific protein 7
GAS7	O60861	37	64	1	62	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
GAS7	O60861	37	64	1	62	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
GAS7	O60861	37	64	1	62	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
GAS7	O60861	180	204	196	456	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
GAS7	O60861	180	204	196	456	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
GAS7	O60861	180	204	196	456	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
GAS7	O60861	37	64	1	140	Alternative sequence	ID=VSP_006802;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
GAS7	O60861	37	64	1	140	Alternative sequence	ID=VSP_006802;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
GAS7	O60861	37	64	1	140	Alternative sequence	ID=VSP_006802;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
GAS7	O60861	37	64	1	64	Alternative sequence	ID=VSP_035988;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455477,ECO:0000303|Ref.4;Dbxref=PMID:15489334,PMID:9455477
GAS7	O60861	37	64	1	64	Alternative sequence	ID=VSP_035988;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455477,ECO:0000303|Ref.4;Dbxref=PMID:15489334,PMID:9455477
GAS7	O60861	37	64	1	64	Alternative sequence	ID=VSP_035988;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455477,ECO:0000303|Ref.4;Dbxref=PMID:15489334,PMID:9455477
GAS7	O60861	37	64	1	60	Alternative sequence	ID=VSP_044294;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455477;Dbxref=PMID:14702039,PMID:9455477
GAS7	O60861	37	64	1	60	Alternative sequence	ID=VSP_044294;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455477;Dbxref=PMID:14702039,PMID:9455477
GAS7	O60861	37	64	1	60	Alternative sequence	ID=VSP_044294;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455477;Dbxref=PMID:14702039,PMID:9455477
GAS7	O60861	37	64	61	61	Alternative sequence	ID=VSP_044295;Note=In isoform 4. E->M;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455477;Dbxref=PMID:14702039,PMID:9455477
GAS7	O60861	37	64	61	61	Alternative sequence	ID=VSP_044295;Note=In isoform 4. E->M;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455477;Dbxref=PMID:14702039,PMID:9455477
GAS7	O60861	37	64	61	61	Alternative sequence	ID=VSP_044295;Note=In isoform 4. E->M;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455477;Dbxref=PMID:14702039,PMID:9455477
GAS7	O60861	37	64	40	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	40	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	40	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	57	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	57	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
GAS7	O60861	37	64	57	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LX7
HEXA	P06865	474	508	89	529	Chain	ID=PRO_0000011994;Note=Beta-hexosaminidase subunit alpha
HEXA	P06865	190	224	89	529	Chain	ID=PRO_0000011994;Note=Beta-hexosaminidase subunit alpha
HEXA	P06865	153	190	89	529	Chain	ID=PRO_0000011994;Note=Beta-hexosaminidase subunit alpha
HEXA	P06865	153	190	157	157	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1533633,ECO:0000269|PubMed:16698036,ECO:0000269|PubMed:19159218;Dbxref=PMID:1533633,PMID:16698036,PMID:19159218
HEXA	P06865	474	508	505	522	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16698036;Dbxref=PMID:16698036
HEXA	P06865	190	224	1	192	Alternative sequence	ID=VSP_056657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HEXA	P06865	153	190	1	192	Alternative sequence	ID=VSP_056657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HEXA	P06865	474	508	361	529	Alternative sequence	ID=VSP_056659;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HEXA	P06865	153	190	166	166	Natural variant	ID=VAR_003205;Note=In GM2G1%3B late infantile. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8581357;Dbxref=PMID:8581357
HEXA	P06865	153	190	170	170	Natural variant	ID=VAR_003206;Note=In GM2G1%3B infantile%3B inactive or unstable protein. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9338583;Dbxref=dbSNP:rs121907957,PMID:9338583
HEXA	P06865	153	190	170	170	Natural variant	ID=VAR_003207;Note=In GM2G1%3B infantile. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1302612,ECO:0000269|PubMed:22723944;Dbxref=dbSNP:rs121907972,PMID:1302612,PMID:22723944
HEXA	P06865	153	190	178	178	Natural variant	ID=VAR_003208;Note=In GM2G1%3B infantile%3B inactive protein. R->C;Dbxref=dbSNP:rs121907953
HEXA	P06865	153	190	178	178	Natural variant	ID=VAR_003209;Note=In GM2G1%3B infantile%3B inactive protein. R->H;Dbxref=dbSNP:rs28941770
HEXA	P06865	153	190	178	178	Natural variant	ID=VAR_003210;Note=In GM2G1%3B infantile. R->L;Dbxref=dbSNP:rs28941770
HEXA	P06865	153	190	180	180	Natural variant	ID=VAR_003211;Note=In GM2G1. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8757036;Dbxref=dbSNP:rs28941771,PMID:8757036
HEXA	P06865	190	224	192	192	Natural variant	ID=VAR_003212;Note=In GM2G1%3B infantile. V->L;Dbxref=dbSNP:rs387906310
HEXA	P06865	190	224	196	196	Natural variant	ID=VAR_003213;Note=In GM2G1. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7717398;Dbxref=dbSNP:rs753862880,PMID:7717398
HEXA	P06865	190	224	197	197	Natural variant	ID=VAR_003214;Note=In GM2G1. K->T;Dbxref=dbSNP:rs121907973
HEXA	P06865	190	224	200	200	Natural variant	ID=VAR_003215;Note=In GM2G1. V->M;Dbxref=dbSNP:rs1800429
HEXA	P06865	190	224	204	204	Natural variant	ID=VAR_003216;Note=In GM2G1%3B infantile. H->R;Dbxref=dbSNP:rs121907976
HEXA	P06865	190	224	210	210	Natural variant	ID=VAR_003217;Note=In GM2G1%3B infantile. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1837283;Dbxref=dbSNP:rs121907961,PMID:1837283
HEXA	P06865	190	224	211	211	Natural variant	ID=VAR_003218;Note=In GM2G1%3B infantile. F->S;Dbxref=dbSNP:rs121907974
HEXA	P06865	474	508	474	474	Natural variant	ID=VAR_003239;Note=In GM2G1%3B subacute. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9603435;Dbxref=dbSNP:rs121907981,PMID:9603435
HEXA	P06865	474	508	478	478	Natural variant	ID=VAR_077502;Note=In GM2G1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22723944;Dbxref=dbSNP:rs1057519467,PMID:22723944
HEXA	P06865	474	508	482	482	Natural variant	ID=VAR_003240;Note=In GM2G1%3B infantile%3B loss of processing to a mature form%3B increased degradation. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27682588,ECO:0000269|PubMed:2970528,ECO:0000269|PubMed:9338583;Dbxref=dbSNP:rs121907952,PMID:27682588,PMID:2970528,PMID:9338583
HEXA	P06865	474	508	484	484	Natural variant	ID=VAR_003241;Note=In GM2G1%3B infantile. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7837766;Dbxref=PMID:7837766
HEXA	P06865	474	508	485	485	Natural variant	ID=VAR_003242;Note=In GM2G1%3B infantile. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1301190;Dbxref=dbSNP:rs121907968,PMID:1301190
HEXA	P06865	474	508	499	499	Natural variant	ID=VAR_003243;Note=In GM2G1%3B infantile. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14566483;Dbxref=dbSNP:rs121907966,PMID:14566483
HEXA	P06865	474	508	499	499	Natural variant	ID=VAR_003244;Note=In GM2G1%3B juvenile. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14566483;Dbxref=dbSNP:rs121907956,PMID:14566483
HEXA	P06865	474	508	504	504	Natural variant	ID=VAR_003245;Note=In GM2G1%3B infantile. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1837283;Dbxref=dbSNP:rs28942071,PMID:1837283
HEXA	P06865	474	508	504	504	Natural variant	ID=VAR_003246;Note=In GM2G1%3B juvenile%3B fails to associate with the beta-subunit to form the enzymatically active heterodimer. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2140574;Dbxref=dbSNP:rs121907955,PMID:2140574
HEXA	P06865	153	190	157	157	Mutagenesis	Note=No change of the catalytic activity associated with the alpha-chain. No catalytic activity associated with the alpha-chain%3B when associated with Q-115 and Q-295. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1533633;Dbxref=PMID:1533633
HEXA	P06865	153	190	154	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	153	190	159	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	153	190	168	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	153	190	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	190	224	183	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	153	190	183	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	190	224	200	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	190	224	216	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GK1
HEXA	P06865	190	224	220	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	474	508	476	485	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXA	P06865	474	508	493	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GJX
HEXB	P07686	148	170	122	556	Chain	ID=PRO_0000012003;Note=Beta-hexosaminidase subunit beta
HEXB	P07686	223	257	122	556	Chain	ID=PRO_0000012003;Note=Beta-hexosaminidase subunit beta
HEXB	P07686	361	389	122	556	Chain	ID=PRO_0000012003;Note=Beta-hexosaminidase subunit beta
HEXB	P07686	503	537	122	556	Chain	ID=PRO_0000012003;Note=Beta-hexosaminidase subunit beta
HEXB	P07686	148	170	122	311	Chain	ID=PRO_0000012004;Note=Beta-hexosaminidase subunit beta chain B
HEXB	P07686	223	257	122	311	Chain	ID=PRO_0000012004;Note=Beta-hexosaminidase subunit beta chain B
HEXB	P07686	361	389	315	556	Chain	ID=PRO_0000012005;Note=Beta-hexosaminidase subunit beta chain A
HEXB	P07686	503	537	315	556	Chain	ID=PRO_0000012005;Note=Beta-hexosaminidase subunit beta chain A
HEXB	P07686	503	537	534	551	Disulfide bond	.
HEXB	P07686	223	257	255	255	Natural variant	ID=VAR_011704;Note=In GM2G2. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9856491;Dbxref=PMID:9856491
HEXB	P07686	503	537	504	504	Natural variant	ID=VAR_011705;Note=In GM2G2. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9694901;Dbxref=PMID:9694901
HEXB	P07686	503	537	505	505	Natural variant	ID=VAR_003253;Note=In GM2G2. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8357844,ECO:0000269|PubMed:8950198;Dbxref=PMID:8357844,PMID:8950198
HEXB	P07686	503	537	534	534	Natural variant	ID=VAR_003254;Note=In GM2G2%3B infantile type. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7626071;Dbxref=PMID:7626071
HEXB	P07686	148	170	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	148	170	155	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	148	170	165	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	223	257	216	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	223	257	233	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	223	257	253	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	361	389	359	362	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	361	389	365	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	361	389	380	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	503	537	505	514	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HEXB	P07686	503	537	522	538	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NOW
HIBCH	Q6NVY1	297	337	33	386	Chain	ID=PRO_0000284929;Note=3-hydroxyisobutyryl-CoA hydrolase%2C mitochondrial
HIBCH	Q6NVY1	221	250	33	386	Chain	ID=PRO_0000284929;Note=3-hydroxyisobutyryl-CoA hydrolase%2C mitochondrial
HIBCH	Q6NVY1	101	128	33	386	Chain	ID=PRO_0000284929;Note=3-hydroxyisobutyryl-CoA hydrolase%2C mitochondrial
HIBCH	Q6NVY1	101	128	121	121	Binding site	Note=Substrate
HIBCH	Q6NVY1	221	250	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZS1
HIBCH	Q6NVY1	221	250	221	221	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZS1
HIBCH	Q6NVY1	221	250	234	234	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HIBCH	Q6NVY1	297	337	297	297	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZS1
HIBCH	Q6NVY1	297	337	297	297	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZS1
HIBCH	Q6NVY1	297	337	301	301	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZS1
HIBCH	Q6NVY1	101	128	122	122	Natural variant	ID=VAR_031870;Note=In HIBCHD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17160907;Dbxref=dbSNP:rs121918329,PMID:17160907
HIBCH	Q6NVY1	101	128	111	111	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HIBCH	Q6NVY1	101	128	100	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	101	128	114	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	221	250	219	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	221	250	222	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	221	250	237	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	297	337	290	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	297	337	304	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIBCH	Q6NVY1	297	337	322	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPT
HIF1A	Q16665	512	553	1	826	Chain	ID=PRO_0000127220;Note=Hypoxia-inducible factor 1-alpha
HIF1A	Q16665	512	553	401	603	Region	Note=ODD
HIF1A	Q16665	512	553	531	575	Region	Note=NTAD
HIF1A	Q16665	512	553	532	532	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681946;Dbxref=PMID:24681946
HIF1A	Q16665	512	553	551	551	Modified residue	Note=Phosphoserine%3B by GSK3-beta;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20889502;Dbxref=PMID:20889502
HIF1A	Q16665	512	553	532	532	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16862177;Dbxref=PMID:16862177
HIF1A	Q16665	512	553	538	538	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16862177;Dbxref=PMID:16862177
HIF1A	Q16665	512	553	547	547	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16862177;Dbxref=PMID:16862177
HIF1A	Q16665	512	553	532	532	Mutagenesis	Note=Reduced ubiquitination. No change in sumoylation nor on interaction with ARD1A. No change in HIF1A protein turnover rate but increased transcriptional activity%3B when associated with R-377%3B R-391 and R-477. Complete loss of ubiquitination%2C but no change in VHL binding%3B when associated with K-538 and K-547. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10944113,ECO:0000269|PubMed:15465032,ECO:0000269|PubMed:16288748,ECO:0000269|PubMed:16862177,ECO:0000269|PubMed:17610843;Dbxref=PMID:10944113,PMID:15465032,PMID:16288748,PMID:16862177,PMID:17610843
HIF1A	Q16665	512	553	538	538	Mutagenesis	Note=No change in sumoylation%2C but reduced ubiquitination. Complete loss of ubiquitination%2C but no change in VHL binding%3B when associated with K-532 and K-547. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10944113,ECO:0000269|PubMed:15465032,ECO:0000269|PubMed:16862177;Dbxref=PMID:10944113,PMID:15465032,PMID:16862177
HIF1A	Q16665	512	553	547	547	Mutagenesis	Note=No change in sumoylation%2C but reduced ubiquitination. Complete loss of ubiquitination%2C but no change in VHL binding%3B when associated with K-532 and K-538. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10944113,ECO:0000269|PubMed:15465032,ECO:0000269|PubMed:16862177;Dbxref=PMID:10944113,PMID:15465032,PMID:16862177
HIF1A	Q16665	512	553	551	551	Mutagenesis	Note=Constitutive expression under nonhypoxic conditions by decreasing ubiquitination. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10758161;Dbxref=PMID:10758161
HIF1A	Q16665	512	553	552	552	Mutagenesis	Note=Constitutive expression under nonhypoxic conditions by decreasing ubiquitination. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10758161;Dbxref=PMID:10758161
HIPK3	Q9H422	407	447	1	1215	Chain	ID=PRO_0000085998;Note=Homeodomain-interacting protein kinase 3
HIPK3	Q9H422	769	789	1	1215	Chain	ID=PRO_0000085998;Note=Homeodomain-interacting protein kinase 3
HIPK3	Q9H422	790	888	1	1215	Chain	ID=PRO_0000085998;Note=Homeodomain-interacting protein kinase 3
HIPK3	Q9H422	889	935	1	1215	Chain	ID=PRO_0000085998;Note=Homeodomain-interacting protein kinase 3
HIPK3	Q9H422	407	447	197	525	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HIPK3	Q9H422	769	789	767	944	Region	Note=Interaction with AR;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	790	888	767	944	Region	Note=Interaction with AR;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	889	935	767	944	Region	Note=Interaction with AR;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	790	888	796	891	Region	Note=Interaction with FAS;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	889	935	796	891	Region	Note=Interaction with FAS;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	790	888	855	1011	Region	Note=Required for localization to nuclear speckles;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	889	935	855	1011	Region	Note=Required for localization to nuclear speckles;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	790	888	866	918	Region	Note=SUMO interaction motifs (SIM)%3B required for nuclear localization and kinase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	889	935	866	918	Region	Note=SUMO interaction motifs (SIM)%3B required for nuclear localization and kinase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
HIPK3	Q9H422	790	888	870	880	Region	Note=Interaction with UBL1;Ontology_term=ECO:0000305;evidence=ECO:0000305
HIPK3	Q9H422	889	935	910	962	Compositional bias	Note=Ser-rich
HIPK3	Q9H422	769	789	770	790	Alternative sequence	ID=VSP_013140;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11034606;Dbxref=PMID:11034606
HIPK3	Q9H422	790	888	770	790	Alternative sequence	ID=VSP_013140;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11034606;Dbxref=PMID:11034606
FN3K	Q9H479	156	197	1	309	Chain	ID=PRO_0000216337;Note=Fructosamine-3-kinase
FOCAD	Q5VW36	19	44	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	96	130	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	233	302	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	485	520	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	875	906	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	936	950	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	1377	1420	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	1546	1576	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	19	44	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	96	130	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	233	302	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	485	520	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	875	906	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	936	950	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	1377	1420	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	1546	1576	1	1801	Chain	ID=PRO_0000314457;Note=Focadhesin
FOCAD	Q5VW36	233	302	234	234	Natural variant	ID=VAR_037878;Note=V->I;Dbxref=dbSNP:rs10441706
FOCAD	Q5VW36	233	302	234	234	Natural variant	ID=VAR_037878;Note=V->I;Dbxref=dbSNP:rs10441706
ZFPM2	Q8WW38	177	246	1	1151	Chain	ID=PRO_0000221043;Note=Zinc finger protein ZFPM2
ZFPM2	Q8WW38	177	246	244	277	Zinc finger	Note=CCHC FOG-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01153
ZFPM2	Q8WW38	177	246	227	227	Natural variant	ID=VAR_072074;Note=In CTHM. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20807224;Dbxref=dbSNP:rs202204708,PMID:20807224
ZFPM2	Q8WW38	177	246	198	198	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
FNIP2	Q9P278	383	431	1	1114	Chain	ID=PRO_0000320553;Note=Folliculin-interacting protein 2
FNIP2	Q9P278	983	1050	1	1114	Chain	ID=PRO_0000320553;Note=Folliculin-interacting protein 2
FNIP2	Q9P278	383	431	42	460	Domain	Note=uDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180
FNIP2	Q9P278	983	1050	468	1040	Domain	Note=cDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180
FNIP2	Q9P278	983	1050	1050	1105	Domain	Note=dDENN FNIP1/2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01180
HDAC5	Q9UQL6	257	306	1	1122	Chain	ID=PRO_0000114701;Note=Histone deacetylase 5
HDAC5	Q9UQL6	7	31	1	1122	Chain	ID=PRO_0000114701;Note=Histone deacetylase 5
HDAC5	Q9UQL6	257	306	259	259	Modified residue	Note=Phosphoserine%3B by AMPK%2C CaMK1%2C SIK1 and PKD/PRKD1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11114197,ECO:0000269|PubMed:18184930,ECO:0000269|PubMed:18332134;Dbxref=PMID:11114197,PMID:18184930,PMID:18332134
HDAC5	Q9UQL6	257	306	292	292	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20188095;Dbxref=PMID:20188095
HDAC5	Q9UQL6	7	31	7	7	Alternative sequence	ID=VSP_039180;Note=In isoform 3. S->SA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
HDAC5	Q9UQL6	257	306	259	259	Mutagenesis	Note=Reduces AMPK- and caMK-dependent phosphorylation and the subsequent nuclear export. Abolishes nuclear export%3B when associated with A-498. Does not affect phosphorylation by PKN1 and PKN2. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11081517,ECO:0000269|PubMed:18184930,ECO:0000269|PubMed:20188095;Dbxref=PMID:11081517,PMID:18184930,PMID:20188095
HDAC5	Q9UQL6	257	306	279	279	Mutagenesis	Note=No effect. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11081517;Dbxref=PMID:11081517
HDAC5	Q9UQL6	257	306	291	291	Mutagenesis	Note=Does not affect phosphorylation by PKC. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20188095;Dbxref=PMID:20188095
HDAC5	Q9UQL6	257	306	292	292	Mutagenesis	Note=Abolishes phosphorylation by PKC. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20188095;Dbxref=PMID:20188095
FOS	P01100	131	167	1	380	Chain	ID=PRO_0000076465;Note=Proto-oncogene c-Fos
FOS	P01100	131	167	137	200	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
FOS	P01100	131	167	139	159	Region	Note=Basic motif%3B required for the activation of phospholipid synthesis%2C but not for CDS1-binding
FOS	P01100	131	167	165	193	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
FOS	P01100	131	167	132	167	Alternative sequence	ID=VSP_055561;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FOS	P01100	131	167	133	144	Sequence conflict	Note=SPEEEEKRRIRR->ISRRRREKENPK;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOS	P01100	131	167	141	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A02
FOXN1	O15353	41	196	1	648	Chain	ID=PRO_0000091866;Note=Forkhead box protein N1
FOXN1	O15353	378	542	1	648	Chain	ID=PRO_0000091866;Note=Forkhead box protein N1
FOXN1	O15353	41	196	1	648	Chain	ID=PRO_0000091866;Note=Forkhead box protein N1
FOXN1	O15353	378	542	1	648	Chain	ID=PRO_0000091866;Note=Forkhead box protein N1
FOXN1	O15353	41	196	69	69	Natural variant	ID=VAR_020025;Note=R->C;Dbxref=dbSNP:rs2071587
FOXN1	O15353	41	196	69	69	Natural variant	ID=VAR_020025;Note=R->C;Dbxref=dbSNP:rs2071587
FOXN1	O15353	378	542	411	411	Natural variant	ID=VAR_021843;Note=R->W;Dbxref=dbSNP:rs2286520
FOXN1	O15353	378	542	411	411	Natural variant	ID=VAR_021843;Note=R->W;Dbxref=dbSNP:rs2286520
PTGFRN	Q9P2B2	139	277	26	879	Chain	ID=PRO_0000014762;Note=Prostaglandin F2 receptor negative regulator
PTGFRN	Q9P2B2	546	686	26	879	Chain	ID=PRO_0000014762;Note=Prostaglandin F2 receptor negative regulator
PTGFRN	Q9P2B2	686	722	26	879	Chain	ID=PRO_0000014762;Note=Prostaglandin F2 receptor negative regulator
PTGFRN	Q9P2B2	139	277	26	832	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTGFRN	Q9P2B2	546	686	26	832	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTGFRN	Q9P2B2	686	722	26	832	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTGFRN	Q9P2B2	139	277	149	268	Domain	Note=Ig-like C2-type 2
PTGFRN	Q9P2B2	139	277	276	394	Domain	Note=Ig-like C2-type 3
PTGFRN	Q9P2B2	546	686	544	662	Domain	Note=Ig-like C2-type 5
PTGFRN	Q9P2B2	686	722	688	813	Domain	Note=Ig-like C2-type 6
PTGFRN	Q9P2B2	686	722	703	705	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTGFRN	Q9P2B2	139	277	271	271	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62786
PTGFRN	Q9P2B2	546	686	600	600	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17960739;Dbxref=PMID:17960739
PTGFRN	Q9P2B2	546	686	618	618	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17960739;Dbxref=PMID:17960739
PTGFRN	Q9P2B2	686	722	691	691	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17960739;Dbxref=PMID:17960739
PTGFRN	Q9P2B2	139	277	169	247	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PTGFRN	Q9P2B2	546	686	571	655	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PTGFRN	Q9P2B2	686	722	711	793	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PTGFRN	Q9P2B2	139	277	277	277	Natural variant	ID=VAR_059388;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs4546904,PMID:14702039
FTH1	P02794	87	129	1	183	Chain	ID=PRO_0000201048;Note=Ferritin heavy chain
FTH1	P02794	38	87	1	183	Chain	ID=PRO_0000201048;Note=Ferritin heavy chain
FTH1	P02794	87	129	2	183	Chain	ID=PRO_0000424472;Note=Ferritin heavy chain%2C N-terminally processed
FTH1	P02794	38	87	2	183	Chain	ID=PRO_0000424472;Note=Ferritin heavy chain%2C N-terminally processed
FTH1	P02794	87	129	11	160	Domain	Note=Ferritin-like diiron;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00085
FTH1	P02794	38	87	11	160	Domain	Note=Ferritin-like diiron;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00085
FTH1	P02794	38	87	63	63	Metal binding	Note=Iron 1
FTH1	P02794	38	87	63	63	Metal binding	Note=Iron 2
FTH1	P02794	38	87	66	66	Metal binding	Note=Iron 1
FTH1	P02794	87	129	108	108	Metal binding	Note=Iron 2
FTH1	P02794	38	87	15	42	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B8F
FTH1	P02794	38	87	45	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B8F
FTH1	P02794	38	87	50	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B8F
FTH1	P02794	87	129	97	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B8F
FTH1	P02794	87	129	128	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B8F
WDPCP	O95876	478	541	1	746	Chain	ID=PRO_0000325802;Note=WD repeat-containing and planar cell polarity effector protein fritz homolog
WDPCP	O95876	211	275	1	746	Chain	ID=PRO_0000325802;Note=WD repeat-containing and planar cell polarity effector protein fritz homolog
WDPCP	O95876	69	84	1	746	Chain	ID=PRO_0000325802;Note=WD repeat-containing and planar cell polarity effector protein fritz homolog
WDPCP	O95876	69	84	1	166	Alternative sequence	ID=VSP_032408;Note=In isoform 3. MRREFCWDAYSKAAGSRASSPLPRQDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIYQYYDKKDPPATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISD->MFSSLHS;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
WDPCP	O95876	211	275	268	268	Natural variant	ID=VAR_039919;Note=G->S;Dbxref=dbSNP:rs17617459
FSD1	Q9BTV5	81	115	1	496	Chain	ID=PRO_0000316537;Note=Fibronectin type III and SPRY domain-containing protein 1
FSD1	Q9BTV5	81	115	105	162	Domain	Note=COS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00586
FSD1	Q9BTV5	81	115	4	99	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
FYCO1	Q9BQS8	132	179	2	1478	Chain	ID=PRO_0000245837;Note=FYVE and coiled-coil domain-containing protein 1
FYCO1	Q9BQS8	132	179	36	169	Domain	Note=RUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00178
FYCO1	Q9BQS8	132	179	155	155	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD4	P59646	32	57	21	89	Chain	ID=PRO_0000010366;Note=FXYD domain-containing ion transport regulator 4
FXYD4	P59646	32	57	21	38	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD4	P59646	32	57	39	59	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
G3BP2	Q9UN86	242	275	2	482	Chain	ID=PRO_0000194800;Note=Ras GTPase-activating protein-binding protein 2
G3BP2	Q9UN86	59	117	2	482	Chain	ID=PRO_0000194800;Note=Ras GTPase-activating protein-binding protein 2
G3BP2	Q9UN86	242	275	2	482	Chain	ID=PRO_0000194800;Note=Ras GTPase-activating protein-binding protein 2
G3BP2	Q9UN86	59	117	2	482	Chain	ID=PRO_0000194800;Note=Ras GTPase-activating protein-binding protein 2
G3BP2	Q9UN86	59	117	11	133	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
G3BP2	Q9UN86	59	117	11	133	Domain	Note=NTF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00137
G3BP2	Q9UN86	242	275	243	275	Alternative sequence	ID=VSP_003605;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1,ECO:0000303|Ref.3,ECO:0000303|Ref.4;Dbxref=PMID:15489334
G3BP2	Q9UN86	242	275	243	275	Alternative sequence	ID=VSP_003605;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1,ECO:0000303|Ref.3,ECO:0000303|Ref.4;Dbxref=PMID:15489334
G3BP2	Q9UN86	242	275	267	267	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
G3BP2	Q9UN86	242	275	267	267	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
G3BP2	Q9UN86	59	117	58	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	58	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	74	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	74	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	90	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	90	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	106	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
G3BP2	Q9UN86	59	117	106	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DRV
SLC37A1	P57057	283	327	1	533	Chain	ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1
SLC37A1	P57057	283	327	1	533	Chain	ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1
SLC37A1	P57057	283	327	304	324	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A1	P57057	283	327	304	324	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A1	P57057	283	327	303	303	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC37A1	P57057	283	327	303	303	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
GABPB2	Q8TAK5	36	92	1	448	Chain	ID=PRO_0000325908;Note=GA-binding protein subunit beta-2
GABPB2	Q8TAK5	92	157	1	448	Chain	ID=PRO_0000325908;Note=GA-binding protein subunit beta-2
GABPB2	Q8TAK5	207	245	1	448	Chain	ID=PRO_0000325908;Note=GA-binding protein subunit beta-2
GABPB2	Q8TAK5	245	307	1	448	Chain	ID=PRO_0000325908;Note=GA-binding protein subunit beta-2
GABPB2	Q8TAK5	36	92	37	66	Repeat	Note=ANK 2
GABPB2	Q8TAK5	36	92	70	99	Repeat	Note=ANK 3
GABPB2	Q8TAK5	92	157	70	99	Repeat	Note=ANK 3
GABPB2	Q8TAK5	92	157	103	132	Repeat	Note=ANK 4
GABPB2	Q8TAK5	92	157	136	166	Repeat	Note=ANK 5
GABPB2	Q8TAK5	245	307	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P81069
GABPB2	Q8TAK5	36	92	62	62	Natural variant	ID=VAR_039950;Note=V->I;Dbxref=dbSNP:rs11204774
GABPB2	Q8TAK5	92	157	144	144	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
GALE	Q14376	265	291	1	348	Chain	ID=PRO_0000183189;Note=UDP-glucose 4-epimerase
GALE	Q14376	176	214	1	348	Chain	ID=PRO_0000183189;Note=UDP-glucose 4-epimerase
GALE	Q14376	79	117	1	348	Chain	ID=PRO_0000183189;Note=UDP-glucose 4-epimerase
GALE	Q14376	176	214	185	187	Region	Note=Substrate binding;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11279032,ECO:0000269|PubMed:11279193;Dbxref=PMID:11279032,PMID:11279193
GALE	Q14376	176	214	206	208	Region	Note=Substrate binding;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10801319,ECO:0000269|PubMed:11279032,ECO:0000269|PubMed:11279193;Dbxref=PMID:10801319,PMID:11279032,PMID:11279193
GALE	Q14376	79	117	88	88	Binding site	Note=NAD%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10801319,ECO:0000269|PubMed:11279032,ECO:0000269|PubMed:11279193;Dbxref=PMID:10801319,PMID:11279032,PMID:11279193
GALE	Q14376	79	117	92	92	Binding site	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10801319,ECO:0000269|PubMed:11279032,ECO:0000269|PubMed:11279193;Dbxref=PMID:10801319,PMID:11279032,PMID:11279193
GALE	Q14376	176	214	185	185	Binding site	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10801319;Dbxref=PMID:10801319
GALE	Q14376	79	117	1	79	Alternative sequence	ID=VSP_056822;Note=In isoform 2. MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKK->MSPLQ
GALE	Q14376	79	117	90	90	Natural variant	ID=VAR_002540;Note=In EDG%3B 800-fold decrease in UDP-galactose epimerization activity. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11903335,ECO:0000269|PubMed:16302980,ECO:0000269|PubMed:9538513,ECO:0000269|PubMed:9973283;Dbxref=dbSNP:rs28940882,PMID:11903335,PMID:16302980,PMID:9538513,PMID:9973283
GALE	Q14376	79	117	94	94	Natural variant	ID=VAR_010058;Note=In EDG%3B generalized%3B 30-fold decrease in UDP-galactose epimerization activity%3B 2-fold decrease in affinity for UDP-galactose%3B 24%25 of normal activity with respect to UDP-N-acetylgalactosamine. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11117433,ECO:0000269|PubMed:11903335,ECO:0000269|PubMed:16302980,ECO:0000269|PubMed:9973283;Dbxref=dbSNP:rs121908047,PMID:11117433,PMID:11903335,PMID:16302980,PMID:9973283
GALE	Q14376	79	117	103	103	Natural variant	ID=VAR_002541;Note=In EDG%3B 7-fold decrease in UDP-galactose epimerization activity%3B very mild decrease in activity towards UDP-N-acetylgalactosamine. D->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11903335,ECO:0000269|PubMed:16302980,ECO:0000269|PubMed:9538513,ECO:0000269|PubMed:9973283;Dbxref=dbSNP:rs28940883,PMID:11903335,PMID:16302980,PMID:9538513,PMID:9973283
GALE	Q14376	176	214	180	180	Natural variant	ID=VAR_002542;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8593531,ECO:0000269|PubMed:9326324;Dbxref=dbSNP:rs3204468,PMID:8593531,PMID:9326324
GALE	Q14376	176	214	183	183	Natural variant	ID=VAR_002543;Note=In EDG%3B peripheral%3B 3-fold decrease in UDP-galactose epimerization activity. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11903335,ECO:0000269|PubMed:16302980,ECO:0000269|PubMed:9326324;Dbxref=dbSNP:rs121908045,PMID:11903335,PMID:16302980,PMID:9326324
GALE	Q14376	79	117	70	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	79	117	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	79	117	94	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	79	117	101	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	176	214	179	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	176	214	187	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	176	214	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK5
GALE	Q14376	176	214	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	176	214	208	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	265	291	264	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GALE	Q14376	265	291	277	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EK6
GANC	Q8TET4	500	548	1	914	Chain	ID=PRO_0000185364;Note=Neutral alpha-glucosidase C
GANC	Q8TET4	500	548	511	511	Active site	Note=Nucleophile;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10066
GANC	Q8TET4	500	548	514	514	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
MCM3AP	O60318	1334	1378	1	1980	Chain	ID=PRO_0000096284;Note=Germinal-center associated nuclear protein
MCM3AP	O60318	1194	1244	1	1980	Chain	ID=PRO_0000096284;Note=Germinal-center associated nuclear protein
MCM3AP	O60318	666	732	1	1980	Chain	ID=PRO_0000096284;Note=Germinal-center associated nuclear protein
MCM3AP	O60318	1334	1378	1	1980	Chain	ID=PRO_0000096284;Note=Germinal-center associated nuclear protein
MCM3AP	O60318	1194	1244	1	1980	Chain	ID=PRO_0000096284;Note=Germinal-center associated nuclear protein
MCM3AP	O60318	666	732	1	1980	Chain	ID=PRO_0000096284;Note=Germinal-center associated nuclear protein
MCM3AP	O60318	1194	1244	1162	1256	Region	Note=CID
MCM3AP	O60318	1194	1244	1162	1256	Region	Note=CID
MCM3AP	O60318	1194	1244	1	1259	Alternative sequence	ID=VSP_053438;Note=In isoform MCM3AP. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM3AP	O60318	666	732	1	1259	Alternative sequence	ID=VSP_053438;Note=In isoform MCM3AP. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM3AP	O60318	1194	1244	1	1259	Alternative sequence	ID=VSP_053438;Note=In isoform MCM3AP. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM3AP	O60318	666	732	1	1259	Alternative sequence	ID=VSP_053438;Note=In isoform MCM3AP. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCM3AP	O60318	1194	1244	1168	1232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DHX
MCM3AP	O60318	1194	1244	1168	1232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DHX
GALNT6	Q8NCL4	534	585	1	622	Chain	ID=PRO_0000059114;Note=Polypeptide N-acetylgalactosaminyltransferase 6
GALNT6	Q8NCL4	456	500	1	622	Chain	ID=PRO_0000059114;Note=Polypeptide N-acetylgalactosaminyltransferase 6
GALNT6	Q8NCL4	221	271	1	622	Chain	ID=PRO_0000059114;Note=Polypeptide N-acetylgalactosaminyltransferase 6
GALNT6	Q8NCL4	534	585	1	622	Chain	ID=PRO_0000059114;Note=Polypeptide N-acetylgalactosaminyltransferase 6
GALNT6	Q8NCL4	456	500	1	622	Chain	ID=PRO_0000059114;Note=Polypeptide N-acetylgalactosaminyltransferase 6
GALNT6	Q8NCL4	221	271	1	622	Chain	ID=PRO_0000059114;Note=Polypeptide N-acetylgalactosaminyltransferase 6
GALNT6	Q8NCL4	534	585	29	622	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	456	500	29	622	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	221	271	29	622	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	534	585	29	622	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	456	500	29	622	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	221	271	29	622	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	534	585	496	622	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	456	500	496	622	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	534	585	496	622	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	456	500	496	622	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	221	271	176	285	Region	Note=Catalytic subdomain A
GALNT6	Q8NCL4	221	271	176	285	Region	Note=Catalytic subdomain A
GALNT6	Q8NCL4	221	271	269	269	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT6	Q8NCL4	221	271	269	269	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT6	Q8NCL4	221	271	271	271	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT6	Q8NCL4	221	271	271	271	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT6	Q8NCL4	221	271	246	246	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT6	Q8NCL4	221	271	246	246	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GALNT6	Q8NCL4	456	500	476	476	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	456	500	476	476	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT6	Q8NCL4	221	271	165	402	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	221	271	165	402	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	456	500	393	474	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	456	500	393	474	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	534	585	553	566	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	534	585	553	566	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT6	Q8NCL4	534	585	551	551	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GALNT6	Q8NCL4	534	585	551	551	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GALNT7	Q86SF2	463	536	1	657	Chain	ID=PRO_0000059116;Note=N-acetylgalactosaminyltransferase 7
GALNT7	Q86SF2	463	536	30	657	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
GALNT7	Q86SF2	463	536	532	652	Domain	Note=Ricin B-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT7	Q86SF2	463	536	426	507	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00174
GALNT7	Q86SF2	463	536	508	508	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
FECH	P22830	359	379	55	423	Chain	ID=PRO_0000008873;Note=Ferrochelatase%2C mitochondrial
FECH	P22830	304	359	55	423	Chain	ID=PRO_0000008873;Note=Ferrochelatase%2C mitochondrial
FECH	P22830	235	268	55	423	Chain	ID=PRO_0000008873;Note=Ferrochelatase%2C mitochondrial
FECH	P22830	154	199	55	423	Chain	ID=PRO_0000008873;Note=Ferrochelatase%2C mitochondrial
FECH	P22830	65	104	55	423	Chain	ID=PRO_0000008873;Note=Ferrochelatase%2C mitochondrial
FECH	P22830	154	199	196	196	Metal binding	Note=Iron-sulfur (2Fe-2S)
FECH	P22830	65	104	71	71	Natural variant	ID=VAR_030554;Note=In EPP1%3B enzyme totally inactive. I->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9585598;Dbxref=PMID:9585598
FECH	P22830	65	104	96	96	Natural variant	ID=VAR_012028;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2260980,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1041951,PMID:2260980
FECH	P22830	154	199	178	178	Natural variant	ID=VAR_030557;Note=In EPP1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12601550;Dbxref=PMID:12601550
FECH	P22830	154	199	182	182	Natural variant	ID=VAR_030558;Note=In EPP1%3B enzyme totally inactive. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11375302;Dbxref=PMID:11375302
FECH	P22830	154	199	186	186	Natural variant	ID=VAR_002384;Note=In EPP1. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8757534;Dbxref=PMID:8757534
FECH	P22830	154	199	191	191	Natural variant	ID=VAR_030559;Note=In EPP1%3B enzyme retains 72%25 of activity. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9585598;Dbxref=dbSNP:rs1055019947,PMID:9585598
FECH	P22830	154	199	192	192	Natural variant	ID=VAR_030560;Note=In EPP1%3B enzyme totally inactive. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9585598;Dbxref=PMID:9585598
FECH	P22830	235	268	236	236	Natural variant	ID=VAR_030561;Note=In EPP1%3B enzyme retains 12%25 of activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15286165;Dbxref=dbSNP:rs761962617,PMID:15286165
FECH	P22830	235	268	260	260	Natural variant	ID=VAR_030562;Note=In EPP1%3B enzyme retains 52%25 of activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15286165;Dbxref=PMID:15286165
FECH	P22830	235	268	264	264	Natural variant	ID=VAR_054629;Note=In EPP1. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17196862;Dbxref=PMID:17196862
FECH	P22830	235	268	267	267	Natural variant	ID=VAR_002385;Note=In EPP1%3B unchanged activity%3B but increased thermolability. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1755842;Dbxref=dbSNP:rs118204037,PMID:1755842
FECH	P22830	304	359	334	334	Natural variant	ID=VAR_030565;Note=In EPP1%3B enzyme retains 19%25 of activity. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12601550,ECO:0000269|PubMed:9585598;Dbxref=dbSNP:rs150146721,PMID:12601550,PMID:9585598
FECH	P22830	359	379	362	362	Natural variant	ID=VAR_030566;Note=In EPP1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7910885;Dbxref=dbSNP:rs118204040,PMID:7910885
FECH	P22830	359	379	379	379	Natural variant	ID=VAR_030567;Note=In EPP1%3B enzyme retains 37%25 of activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15286165;Dbxref=PMID:15286165
FECH	P22830	154	199	196	196	Mutagenesis	Note=Loss of activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276824;Dbxref=PMID:8276824
FECH	P22830	359	379	360	360	Mutagenesis	Note=No loss of activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276824;Dbxref=PMID:8276824
FECH	P22830	65	104	69	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	65	104	82	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	65	104	85	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	65	104	96	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	65	104	104	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	154	199	152	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	154	199	156	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	154	199	170	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	154	199	183	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	154	199	196	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	154	199	199	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	235	268	231	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	235	268	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	235	268	253	255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	235	268	257	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	235	268	267	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	304	359	306	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HRC
FECH	P22830	304	359	310	314	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	304	359	315	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	304	359	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	304	359	345	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	359	379	350	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	304	359	350	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	359	379	364	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
FECH	P22830	359	379	371	373	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KLR
FECH	P22830	359	379	375	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCN
GARNL3	Q5VVW2	48	73	1	1013	Chain	ID=PRO_0000312215;Note=GTPase-activating Rap/Ran-GAP domain-like protein 3
GARNL3	Q5VVW2	645	698	1	1013	Chain	ID=PRO_0000312215;Note=GTPase-activating Rap/Ran-GAP domain-like protein 3
GARNL3	Q5VVW2	645	698	489	800	Domain	Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795
GARNL3	Q5VVW2	48	73	1	770	Alternative sequence	ID=VSP_029745;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GARNL3	Q5VVW2	645	698	1	770	Alternative sequence	ID=VSP_029745;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GARNL3	Q5VVW2	645	698	466	1013	Alternative sequence	ID=VSP_029742;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HEMK1	Q9Y5R4	138	183	1	338	Chain	ID=PRO_0000157178;Note=HemK methyltransferase family member 1
HEMK1	Q9Y5R4	138	183	1	338	Chain	ID=PRO_0000157178;Note=HemK methyltransferase family member 1
HEMK1	Q9Y5R4	138	183	1	338	Chain	ID=PRO_0000157178;Note=HemK methyltransferase family member 1
HEMK1	Q9Y5R4	138	183	167	171	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
HEMK1	Q9Y5R4	138	183	167	171	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
HEMK1	Q9Y5R4	138	183	167	171	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
HPX	P02790	234	278	24	462	Chain	ID=PRO_0000021406;Note=Hemopexin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	163	234	24	462	Chain	ID=PRO_0000021406;Note=Hemopexin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	47	71	24	462	Chain	ID=PRO_0000021406;Note=Hemopexin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	47	71	53	93	Repeat	Note=Hemopexin 1
HPX	P02790	163	234	140	184	Repeat	Note=Hemopexin 3
HPX	P02790	163	234	185	231	Repeat	Note=Hemopexin 4
HPX	P02790	234	278	259	304	Repeat	Note=Hemopexin 5
HPX	P02790	234	278	236	236	Metal binding	Note=Iron (heme 2 axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250
HPX	P02790	47	71	64	64	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19838169,ECO:0000269|PubMed:6371807;Dbxref=PMID:16335952,PMID:19838169,PMID:6371807
HPX	P02790	163	234	187	187	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19838169,ECO:0000269|PubMed:6371807;Dbxref=PMID:14760718,PMID:15084671,PMID:16335952,PMID:16740002,PMID:19139490,PMID:19159218,PMID:19838169,PMID:6371807
HPX	P02790	234	278	240	240	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:6371807,ECO:0000269|PubMed:6510521;Dbxref=PMID:14760718,PMID:6371807,PMID:6510521
HPX	P02790	234	278	246	246	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:6371807,ECO:0000269|PubMed:6510521;Dbxref=PMID:14760718,PMID:6371807,PMID:6510521
HPX	P02790	163	234	50	231	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	47	71	50	231	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	163	234	188	200	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	234	278	257	460	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3855550;Dbxref=PMID:3855550
HPX	P02790	47	71	52	52	Natural variant	ID=VAR_047137;Note=D->N;Dbxref=dbSNP:rs10839564
HPN	P05981	5	39	1	162	Chain	ID=PRO_0000027841;Note=Serine protease hepsin non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	39	53	1	162	Chain	ID=PRO_0000027841;Note=Serine protease hepsin non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	97	137	1	162	Chain	ID=PRO_0000027841;Note=Serine protease hepsin non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	5	39	1	162	Chain	ID=PRO_0000027841;Note=Serine protease hepsin non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	39	53	1	162	Chain	ID=PRO_0000027841;Note=Serine protease hepsin non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	97	137	1	162	Chain	ID=PRO_0000027841;Note=Serine protease hepsin non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	5	39	1	23	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	5	39	1	23	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	5	39	24	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	39	53	24	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	5	39	24	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	39	53	24	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	39	53	45	417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	97	137	45	417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	39	53	45	417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	97	137	45	417	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
HPN	P05981	97	137	54	151	Domain	Note=SRCR
HPN	P05981	97	137	54	151	Domain	Note=SRCR
HPN	P05981	97	137	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
HPN	P05981	97	137	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
HPN	P05981	97	137	77	140	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1O5E,ECO:0000244|PDB:1O5F,ECO:0000244|PDB:1P57,ECO:0000244|PDB:1Z8G,ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:12962630,ECO:0000269|PubMed:15839837;Dbxref=PMID:12962630,PMID:15839837
HPN	P05981	97	137	77	140	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1O5E,ECO:0000244|PDB:1O5F,ECO:0000244|PDB:1P57,ECO:0000244|PDB:1Z8G,ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:12962630,ECO:0000269|PubMed:15839837;Dbxref=PMID:12962630,PMID:15839837
HPN	P05981	97	137	90	150	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1O5E,ECO:0000244|PDB:1O5F,ECO:0000244|PDB:1P57,ECO:0000244|PDB:1Z8G,ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:12962630,ECO:0000269|PubMed:15839837;Dbxref=PMID:12962630,PMID:15839837
HPN	P05981	97	137	90	150	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1O5E,ECO:0000244|PDB:1O5F,ECO:0000244|PDB:1P57,ECO:0000244|PDB:1Z8G,ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:12962630,ECO:0000269|PubMed:15839837;Dbxref=PMID:12962630,PMID:15839837
HPN	P05981	97	137	119	138	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1O5E,ECO:0000244|PDB:1O5F,ECO:0000244|PDB:1P57,ECO:0000244|PDB:1Z8G,ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:12962630,ECO:0000269|PubMed:15839837;Dbxref=PMID:12962630,PMID:15839837
HPN	P05981	97	137	119	138	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1O5E,ECO:0000244|PDB:1O5F,ECO:0000244|PDB:1P57,ECO:0000244|PDB:1Z8G,ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:12962630,ECO:0000269|PubMed:15839837;Dbxref=PMID:12962630,PMID:15839837
HPN	P05981	39	53	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	39	53	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	98	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	98	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	106	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	106	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	122	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	122	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	125	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	125	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	131	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	131	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	135	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
HPN	P05981	97	137	135	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8G
GBA2	Q9HCG7	189	262	1	927	Chain	ID=PRO_0000283758;Note=Non-lysosomal glucosylceramidase
GBA2	Q9HCG7	189	262	1	287	Alternative sequence	ID=VSP_024383;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
GBA2	Q9HCG7	189	262	222	222	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
HIP1R	O75146	984	1053	1	1068	Chain	ID=PRO_0000083984;Note=Huntingtin-interacting protein 1-related protein
HIP1R	O75146	984	1053	771	1012	Domain	Note=I/LWEQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00292
HIP1R	O75146	984	1053	1017	1017	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
HIP1R	O75146	984	1053	616	1068	Alternative sequence	ID=VSP_054239;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HIP1	O00291	201	248	1	1037	Chain	ID=PRO_0000083986;Note=Huntingtin-interacting protein 1
HIP1	O00291	201	248	245	251	Sequence conflict	Note=KLHSCLP->EFAAAST;Ontology_term=ECO:0000305;evidence=ECO:0000305
GCC2	Q8IWJ2	107	929	1	1684	Chain	ID=PRO_0000190074;Note=GRIP and coiled-coil domain-containing protein 2
GCC2	Q8IWJ2	1060	1115	1	1684	Chain	ID=PRO_0000190074;Note=GRIP and coiled-coil domain-containing protein 2
GCC2	Q8IWJ2	1115	1150	1	1684	Chain	ID=PRO_0000190074;Note=GRIP and coiled-coil domain-containing protein 2
GCC2	Q8IWJ2	1264	1310	1	1684	Chain	ID=PRO_0000190074;Note=GRIP and coiled-coil domain-containing protein 2
GCC2	Q8IWJ2	107	929	110	1618	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GCC2	Q8IWJ2	1060	1115	110	1618	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GCC2	Q8IWJ2	1115	1150	110	1618	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GCC2	Q8IWJ2	1264	1310	110	1618	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
GCC2	Q8IWJ2	107	929	236	236	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
GCC2	Q8IWJ2	107	929	46	1684	Alternative sequence	ID=VSP_040107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
GCC2	Q8IWJ2	1060	1115	46	1684	Alternative sequence	ID=VSP_040107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
GCC2	Q8IWJ2	1115	1150	46	1684	Alternative sequence	ID=VSP_040107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
GCC2	Q8IWJ2	1264	1310	46	1684	Alternative sequence	ID=VSP_040107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
GCC2	Q8IWJ2	1115	1150	1134	1134	Natural variant	ID=VAR_046635;Note=Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2718698
GCC2	Q8IWJ2	1264	1310	1298	1298	Natural variant	ID=VAR_016101;Note=R->G;Dbxref=dbSNP:rs1061202
CFHR2	P36980	19	84	19	270	Chain	ID=PRO_0000005897;Note=Complement factor H-related protein 2
CFHR2	P36980	84	143	19	270	Chain	ID=PRO_0000005897;Note=Complement factor H-related protein 2
CFHR2	P36980	19	84	22	84	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	84	143	22	84	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	84	143	85	142	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	84	143	126	126	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1533657,ECO:0000269|PubMed:19159218;Dbxref=PMID:1533657,PMID:19159218
CFHR2	P36980	19	84	23	72	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	19	84	55	83	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	84	143	87	129	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	84	143	114	140	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CFHR2	P36980	84	143	85	85	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
FKBP6	O75344	58	88	1	327	Chain	ID=PRO_0000075329;Note=Inactive peptidyl-prolyl cis-trans isomerase FKBP6
FKBP6	O75344	156	196	1	327	Chain	ID=PRO_0000075329;Note=Inactive peptidyl-prolyl cis-trans isomerase FKBP6
FKBP6	O75344	58	88	54	143	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
FKBP6	O75344	156	196	171	204	Repeat	Note=TPR 1
FKBP6	O75344	58	88	59	88	Alternative sequence	ID=VSP_054251;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
FKBP6	O75344	156	196	183	183	Natural variant	ID=VAR_070840;Note=Probable polymorphism. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16227348;Dbxref=dbSNP:rs147213094,PMID:16227348
FKBP6	O75344	58	88	56	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B7X
FKBP6	O75344	58	88	72	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B7X
FLVCR2	Q9UPI3	270	317	1	526	Chain	ID=PRO_0000084846;Note=Feline leukemia virus subgroup C receptor-related protein 2
FLVCR2	Q9UPI3	270	317	252	272	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR2	Q9UPI3	270	317	310	330	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLVCR2	Q9UPI3	270	317	280	280	Natural variant	ID=VAR_064043;Note=In PVHH. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20206334;Dbxref=dbSNP:rs267606823,PMID:20206334
FMO5	P49326	45	108	1	533	Chain	ID=PRO_0000147665;Note=Dimethylaniline monooxygenase [N-oxide-forming] 5
FMO5	P49326	45	108	62	63	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HFE4
FMO5	P49326	45	108	54	54	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
FMO5	P49326	45	108	56	56	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
FMO5	P49326	45	108	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
HDAC6	Q9UBN7	246	268	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	311	333	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	729	779	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	1101	1150	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	1150	1193	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	246	268	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	311	333	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	729	779	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	1101	1150	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	1150	1193	1	1215	Chain	ID=PRO_0000114703;Note=Histone deacetylase 6
HDAC6	Q9UBN7	1101	1150	1131	1192	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
HDAC6	Q9UBN7	1150	1193	1131	1192	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
HDAC6	Q9UBN7	1101	1150	1131	1192	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
HDAC6	Q9UBN7	1150	1193	1131	1192	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
HDAC6	Q9UBN7	246	268	87	404	Region	Note=Histone deacetylase 1
HDAC6	Q9UBN7	311	333	87	404	Region	Note=Histone deacetylase 1
HDAC6	Q9UBN7	246	268	87	404	Region	Note=Histone deacetylase 1
HDAC6	Q9UBN7	311	333	87	404	Region	Note=Histone deacetylase 1
HDAC6	Q9UBN7	729	779	482	800	Region	Note=Histone deacetylase 2
HDAC6	Q9UBN7	729	779	482	800	Region	Note=Histone deacetylase 2
HDAC6	Q9UBN7	1150	1193	1154	1156	Region	Note=Ubiquitin binding
HDAC6	Q9UBN7	1150	1193	1154	1156	Region	Note=Ubiquitin binding
HDAC6	Q9UBN7	1150	1193	1182	1189	Region	Note=Ubiquitin binding
HDAC6	Q9UBN7	1150	1193	1182	1189	Region	Note=Ubiquitin binding
HDAC6	Q9UBN7	1101	1150	1113	1113	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1101	1150	1113	1113	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1101	1150	1115	1115	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1101	1150	1115	1115	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1101	1150	1133	1133	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1101	1150	1133	1133	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1101	1150	1136	1136	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1101	1150	1136	1136	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1101	1150	1145	1145	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1101	1150	1145	1145	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1101	1150	1148	1148	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1101	1150	1148	1148	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1150	1193	1153	1153	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1150	1193	1153	1153	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1150	1193	1160	1160	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1150	1193	1160	1160	Metal binding	Note=Zinc 3
HDAC6	Q9UBN7	1150	1193	1164	1164	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1150	1193	1164	1164	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1150	1193	1170	1170	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1150	1193	1170	1170	Metal binding	Note=Zinc 2
HDAC6	Q9UBN7	1150	1193	1183	1183	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1150	1193	1183	1183	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1150	1193	1186	1186	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	1150	1193	1186	1186	Metal binding	Note=Zinc 1
HDAC6	Q9UBN7	729	779	723	730	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	723	730	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	733	739	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	733	739	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	742	744	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	742	744	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	748	750	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	748	750	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	756	766	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	756	766	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	770	772	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	770	772	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	774	778	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	729	779	774	778	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EDU
HDAC6	Q9UBN7	1101	1150	1116	1118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1116	1118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1134	1136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1134	1136	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1140	1145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1140	1145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1146	1148	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1101	1150	1146	1148	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1151	1153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1151	1153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1155	1158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1155	1158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1160	1168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1160	1168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1172	1175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1172	1175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1176	1178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1176	1178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1181	1183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1181	1183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1184	1187	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1184	1187	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1188	1190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1188	1190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1193	1195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
HDAC6	Q9UBN7	1150	1193	1193	1195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B8D
FOSL2	P15408	34	118	1	326	Chain	ID=PRO_0000076483;Note=Fos-related antigen 2
FOSL2	P15408	34	118	104	104	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47930
FOSL2	P15408	34	118	35	35	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FOSL2	P15408	34	118	104	104	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
FOSL2	P15408	34	118	1	39	Alternative sequence	ID=VSP_042083;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FOSL2	P15408	34	118	26	34	Alternative sequence	ID=VSP_039128;Note=In isoform 2. YSSGGGGQQ->MVQGWRIKS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2107490;Dbxref=PMID:2107490
FOSL2	P15408	34	118	89	89	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOSL2	P15408	34	118	111	111	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOXK1	P85037	187	248	2	733	Chain	ID=PRO_0000261667;Note=Forkhead box protein K1
FOXK1	P85037	470	565	2	733	Chain	ID=PRO_0000261667;Note=Forkhead box protein K1
FOXK1	P85037	187	248	95	420	Region	Note=Required for interaction with FOXO4 and MEF2C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42128
FOXK1	P85037	187	248	191	191	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
FOXK1	P85037	187	248	213	213	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:21406692,PMID:23186163,PMID:24275569
FOXK1	P85037	187	248	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:21406692,PMID:23186163
FOXK1	P85037	187	248	239	239	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
FOXK1	P85037	187	248	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
FOXK1	P85037	187	248	245	245	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42128
FOXK1	P85037	187	248	247	247	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42128
FOXK1	P85037	187	248	164	187	Alternative sequence	ID=VSP_052240;Note=In isoform 2. GKNGVFVDGAFQRRGAPALQLPKQ->MAYCLGVNFVPSRFCYQLHRLLLR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15289879,ECO:0000303|PubMed:15489334;Dbxref=PMID:15289879,PMID:15489334
FOXK1	P85037	187	248	217	217	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
FOXK1	P85037	187	248	232	232	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
FGFR1OP	O95684	173	193	1	399	Chain	ID=PRO_0000233293;Note=FGFR1 oncogene partner
FGFR1OP	O95684	306	329	1	399	Chain	ID=PRO_0000233293;Note=FGFR1 oncogene partner
FGFR1OP	O95684	173	193	173	174	Site	Note=Breakpoint for translocation to form FGFR1OP-FGFR1 or FGFR1-FGFR1OP fusion proteins
FGFR1OP	O95684	306	329	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FGFR1OP	O95684	173	193	1	249	Alternative sequence	ID=VSP_018119;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FGFR1OP	O95684	173	193	174	193	Alternative sequence	ID=VSP_018120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
FGFR1OP	O95684	173	193	190	190	Natural variant	ID=VAR_061651;Note=A->G;Dbxref=dbSNP:rs34617108
KHSRP	Q92945	158	182	2	711	Chain	ID=PRO_0000050137;Note=Far upstream element-binding protein 2
KHSRP	Q92945	115	128	2	711	Chain	ID=PRO_0000050137;Note=Far upstream element-binding protein 2
KHSRP	Q92945	158	182	144	208	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
KHSRP	Q92945	158	182	68	496	Compositional bias	Note=Gly-rich
KHSRP	Q92945	115	128	68	496	Compositional bias	Note=Gly-rich
KHSRP	Q92945	115	128	125	125	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KHSRP	Q92945	158	182	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
KHSRP	Q92945	115	128	121	121	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
KHSRP	Q92945	115	128	121	121	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KHSRP	Q92945	158	182	153	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
KHSRP	Q92945	158	182	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
KHSRP	Q92945	158	182	165	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
KHSRP	Q92945	158	182	179	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
FUNDC2	Q9BWH2	120	164	1	189	Chain	ID=PRO_0000314615;Note=FUN14 domain-containing protein 2
FUNDC2	Q9BWH2	120	164	151	151	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
FXYD5	Q96DB9	20	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	47	66	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	66	97	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	97	127	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	127	137	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	137	162	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	20	47	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	47	66	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	66	97	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	97	127	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	127	137	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	137	162	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	20	47	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	47	66	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	66	97	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	97	127	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	127	137	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	137	162	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	20	47	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	47	66	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	66	97	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	97	127	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	127	137	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	137	162	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	20	47	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	47	66	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	66	97	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	97	127	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	127	137	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	137	162	22	178	Chain	ID=PRO_0000010369;Note=FXYD domain-containing ion transport regulator 5
FXYD5	Q96DB9	20	47	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	47	66	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	66	97	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	97	127	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	127	137	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	47	66	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	66	97	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	97	127	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	127	137	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	47	66	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	66	97	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	97	127	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	127	137	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	47	66	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	66	97	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	97	127	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	127	137	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	47	66	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	66	97	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	97	127	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	127	137	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	22	145	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	146	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	146	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	146	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	146	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	137	162	146	164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXYD5	Q96DB9	20	47	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	47	66	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	66	97	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	97	127	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	20	47	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	47	66	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	66	97	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	97	127	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	20	47	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	47	66	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	66	97	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	97	127	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	20	47	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	47	66	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	66	97	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	97	127	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	20	47	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	47	66	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	66	97	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	97	127	1	97	Alternative sequence	ID=VSP_001584;Note=In isoform 2. MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKA->MQTLSNIPCFCLHGSLLPSTDLATLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11342114;Dbxref=PMID:11342114
FXYD5	Q96DB9	20	47	35	35	Natural variant	ID=VAR_012349;Note=S->A;Dbxref=dbSNP:rs1688005
FXYD5	Q96DB9	20	47	35	35	Natural variant	ID=VAR_012349;Note=S->A;Dbxref=dbSNP:rs1688005
FXYD5	Q96DB9	20	47	35	35	Natural variant	ID=VAR_012349;Note=S->A;Dbxref=dbSNP:rs1688005
FXYD5	Q96DB9	20	47	35	35	Natural variant	ID=VAR_012349;Note=S->A;Dbxref=dbSNP:rs1688005
FXYD5	Q96DB9	20	47	35	35	Natural variant	ID=VAR_012349;Note=S->A;Dbxref=dbSNP:rs1688005
FXYD5	Q96DB9	137	162	140	141	Sequence conflict	Note=HT->SH;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD5	Q96DB9	137	162	140	141	Sequence conflict	Note=HT->SH;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD5	Q96DB9	137	162	140	141	Sequence conflict	Note=HT->SH;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD5	Q96DB9	137	162	140	141	Sequence conflict	Note=HT->SH;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD5	Q96DB9	137	162	140	141	Sequence conflict	Note=HT->SH;Ontology_term=ECO:0000305;evidence=ECO:0000305
FXYD7	P58549	20	45	1	80	Chain	ID=PRO_0000148190;Note=FXYD domain-containing ion transport regulator 7
FXYD7	P58549	20	45	24	46	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
FXR2	P51116	220	277	1	673	Chain	ID=PRO_0000050110;Note=Fragile X mental retardation syndrome-related protein 2
FXR2	P51116	181	220	1	673	Chain	ID=PRO_0000050110;Note=Fragile X mental retardation syndrome-related protein 2
FXR2	P51116	220	277	232	261	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
FXR2	P51116	181	220	192	192	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FXR2	P51116	220	277	252	252	Natural variant	ID=VAR_067039;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854734,PMID:15489334
OTOGL	Q3ZCN5	967	1012	23	2332	Chain	ID=PRO_0000316765;Note=Otogelin-like protein
OTOGL	Q3ZCN5	967	1012	938	1141	Domain	Note=VWFD 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00580
OXSR1	O95747	200	234	2	527	Chain	ID=PRO_0000086456;Note=Serine/threonine-protein kinase OSR1
OXSR1	O95747	317	358	2	527	Chain	ID=PRO_0000086456;Note=Serine/threonine-protein kinase OSR1
OXSR1	O95747	358	370	2	527	Chain	ID=PRO_0000086456;Note=Serine/threonine-protein kinase OSR1
OXSR1	O95747	458	481	2	527	Chain	ID=PRO_0000086456;Note=Serine/threonine-protein kinase OSR1
OXSR1	O95747	200	234	17	291	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
OXSR1	O95747	317	358	324	324	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
OXSR1	O95747	317	358	325	325	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
OXSR1	O95747	317	358	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18318008,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
OXSR1	O95747	317	358	347	347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
OXSR1	O95747	358	370	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
OXSR1	O95747	317	358	325	325	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
OXSR1	O95747	358	370	363	363	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
OXSR1	O95747	200	234	195	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWI
OXSR1	O95747	200	234	207	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWI
OXSR1	O95747	200	234	226	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWI
OXSR1	O95747	200	234	232	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VWI
OXSR1	O95747	458	481	456	458	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V3S
OXSR1	O95747	458	481	461	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V3S
OXSR1	O95747	458	481	476	478	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V3S
OXSR1	O95747	458	481	479	491	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V3S
P4HA1	P13674	434	456	18	534	Chain	ID=PRO_0000022723;Note=Prolyl 4-hydroxylase subunit alpha-1
P4HA1	P13674	108	154	18	534	Chain	ID=PRO_0000022723;Note=Prolyl 4-hydroxylase subunit alpha-1
P4HA1	P13674	434	456	18	534	Chain	ID=PRO_0000022723;Note=Prolyl 4-hydroxylase subunit alpha-1
P4HA1	P13674	108	154	18	534	Chain	ID=PRO_0000022723;Note=Prolyl 4-hydroxylase subunit alpha-1
P4HA1	P13674	434	456	411	519	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HA1	P13674	434	456	411	519	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HA1	P13674	108	154	113	113	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P4HA1	P13674	108	154	113	113	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P4HA1	P13674	434	456	417	434	Alternative sequence	ID=VSP_044578;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15028279;Dbxref=PMID:15028279
P4HA1	P13674	434	456	417	434	Alternative sequence	ID=VSP_044578;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15028279;Dbxref=PMID:15028279
P4HA1	P13674	108	154	119	122	Sequence conflict	Note=QYFP->PVLS;Ontology_term=ECO:0000305;evidence=ECO:0000305
P4HA1	P13674	108	154	119	122	Sequence conflict	Note=QYFP->PVLS;Ontology_term=ECO:0000305;evidence=ECO:0000305
P4HA1	P13674	108	154	119	122	Sequence conflict	Note=QYFP->PVLS;Ontology_term=ECO:0000305;evidence=ECO:0000305
P4HA1	P13674	108	154	119	122	Sequence conflict	Note=QYFP->PVLS;Ontology_term=ECO:0000305;evidence=ECO:0000305
P4HA1	P13674	108	154	108	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	108	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	145	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	145	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	153	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
P4HA1	P13674	108	154	153	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BTB
PYCR1	P32322	180	211	2	319	Chain	ID=PRO_0000187314;Note=Pyrroline-5-carboxylate reductase 1%2C mitochondrial
PYCR1	P32322	46	106	2	319	Chain	ID=PRO_0000187314;Note=Pyrroline-5-carboxylate reductase 1%2C mitochondrial
PYCR1	P32322	46	106	69	72	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.18
PYCR1	P32322	46	106	95	97	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.18
PYCR1	P32322	46	106	56	56	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.18
PYCR1	P32322	180	211	189	189	Natural variant	ID=VAR_059071;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19648921;Dbxref=PMID:19648921
PYCR1	P32322	180	211	206	206	Natural variant	ID=VAR_059072;Note=In ARCL2B. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19648921;Dbxref=dbSNP:rs121918375,PMID:19648921
PYCR1	P32322	180	211	206	206	Natural variant	ID=VAR_059073;Note=In ARCL2B. G->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19648921;Dbxref=dbSNP:rs121918375,PMID:19648921
PYCR1	P32322	46	106	40	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	51	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	56	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	64	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	72	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	75	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	91	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	46	106	101	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	180	211	177	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
PYCR1	P32322	180	211	199	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UAV
ADCYAP1	P18509	81	113	82	129	Peptide	ID=PRO_0000011487;Note=PACAP-related peptide
ADCYAP1	P18509	81	113	82	129	Peptide	ID=PRO_0000011487;Note=PACAP-related peptide
SCYL3	Q8IZE3	437	491	2	742	Chain	ID=PRO_0000058167;Note=Protein-associating with the carboxyl-terminal domain of ezrin
SCYL3	Q8IZE3	155	174	2	742	Chain	ID=PRO_0000058167;Note=Protein-associating with the carboxyl-terminal domain of ezrin
SCYL3	Q8IZE3	437	491	2	742	Chain	ID=PRO_0000058167;Note=Protein-associating with the carboxyl-terminal domain of ezrin
SCYL3	Q8IZE3	155	174	2	742	Chain	ID=PRO_0000058167;Note=Protein-associating with the carboxyl-terminal domain of ezrin
SCYL3	Q8IZE3	155	174	2	245	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SCYL3	Q8IZE3	155	174	2	245	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SCYL3	Q8IZE3	437	491	439	439	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBQ7
SCYL3	Q8IZE3	437	491	439	439	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DBQ7
SCYL3	Q8IZE3	437	491	438	491	Alternative sequence	ID=VSP_013125;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12651155,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:12651155,PMID:15489334
SCYL3	Q8IZE3	437	491	438	491	Alternative sequence	ID=VSP_013125;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12651155,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:12651155,PMID:15489334
PAEP	P09466	103	140	19	180	Chain	ID=PRO_0000017953;Note=Glycodelin
PAEP	P09466	103	140	19	180	Chain	ID=PRO_0000017953;Note=Glycodelin
PAEP	P09466	103	140	19	180	Chain	ID=PRO_0000017953;Note=Glycodelin
PAEP	P09466	103	140	84	178	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4R0B,ECO:0000269|PubMed:25422905;Dbxref=PMID:25422905
PAEP	P09466	103	140	84	178	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4R0B,ECO:0000269|PubMed:25422905;Dbxref=PMID:25422905
PAEP	P09466	103	140	84	178	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4R0B,ECO:0000269|PubMed:25422905;Dbxref=PMID:25422905
PAEP	P09466	103	140	124	137	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4R0B,ECO:0000269|PubMed:25422905;Dbxref=PMID:25422905
PAEP	P09466	103	140	124	137	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4R0B,ECO:0000269|PubMed:25422905;Dbxref=PMID:25422905
PAEP	P09466	103	140	124	137	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4R0B,ECO:0000269|PubMed:25422905;Dbxref=PMID:25422905
PAEP	P09466	103	140	33	126	Alternative sequence	ID=VSP_003141;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAEP	P09466	103	140	33	126	Alternative sequence	ID=VSP_003141;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAEP	P09466	103	140	33	126	Alternative sequence	ID=VSP_003141;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAEP	P09466	103	140	126	126	Natural variant	ID=VAR_034355;Note=Q->K;Dbxref=dbSNP:rs3748210
PAEP	P09466	103	140	126	126	Natural variant	ID=VAR_034355;Note=Q->K;Dbxref=dbSNP:rs3748210
PAEP	P09466	103	140	126	126	Natural variant	ID=VAR_034355;Note=Q->K;Dbxref=dbSNP:rs3748210
PAEP	P09466	103	140	99	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	99	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	99	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	107	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	107	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	107	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	117	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	117	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	117	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	134	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	134	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAEP	P09466	103	140	134	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R0B
PAF1	Q8N7H5	286	328	1	531	Chain	ID=PRO_0000326400;Note=RNA polymerase II-associated factor 1 homolog
PAF1	Q8N7H5	189	212	1	531	Chain	ID=PRO_0000326400;Note=RNA polymerase II-associated factor 1 homolog
PAF1	Q8N7H5	26	56	1	531	Chain	ID=PRO_0000326400;Note=RNA polymerase II-associated factor 1 homolog
PAF1	Q8N7H5	26	56	17	26	Alternative sequence	ID=VSP_032650;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PAF1	Q8N7H5	189	212	190	212	Alternative sequence	ID=VSP_032651;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAF1	Q8N7H5	189	212	201	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M6T
PAF1	Q8N7H5	189	212	211	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M6T
PAFAH2	Q99487	184	222	2	392	Chain	ID=PRO_0000090383;Note=Platelet-activating factor acetylhydrolase 2%2C cytoplasmic
PAFAH2	Q99487	114	136	2	392	Chain	ID=PRO_0000090383;Note=Platelet-activating factor acetylhydrolase 2%2C cytoplasmic
PAFAH2	Q99487	184	222	2	392	Chain	ID=PRO_0000090383;Note=Platelet-activating factor acetylhydrolase 2%2C cytoplasmic
PAFAH2	Q99487	114	136	2	392	Chain	ID=PRO_0000090383;Note=Platelet-activating factor acetylhydrolase 2%2C cytoplasmic
PAFAH2	Q99487	184	222	212	212	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAFAH2	Q99487	184	222	212	212	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHYH	O14832	276	321	31	338	Chain	ID=PRO_0000024053;Note=Phytanoyl-CoA dioxygenase%2C peroxisomal
PHYH	O14832	45	81	31	338	Chain	ID=PRO_0000024053;Note=Phytanoyl-CoA dioxygenase%2C peroxisomal
PHYH	O14832	45	81	59	59	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35386
PHYH	O14832	276	321	317	317	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PHYH	O14832	45	81	1	100	Alternative sequence	ID=VSP_046289;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHYH	O14832	45	81	57	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1X
PHYH	O14832	45	81	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1X
PHYH	O14832	45	81	75	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1X
PHYH	O14832	276	321	275	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1X
PHYH	O14832	276	321	296	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1X
PHYH	O14832	276	321	320	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1X
SERPINE1	P05121	90	168	24	402	Chain	ID=PRO_0000032499;Note=Plasminogen activator inhibitor 1
SERPINE1	P05121	168	233	24	402	Chain	ID=PRO_0000032499;Note=Plasminogen activator inhibitor 1
SERPINE1	P05121	168	233	232	232	Glycosylation	Note=N-linked (GlcNAc...) asparagine
SERPINE1	P05121	168	233	209	209	Natural variant	ID=VAR_013087;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs2227669
SERPINE1	P05121	168	233	197	197	Mutagenesis	Note=Increased half-life of the active form when associated with C-355. Q->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17912461;Dbxref=PMID:17912461
SERPINE1	P05121	90	168	138	138	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINE1	P05121	168	233	226	226	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINE1	P05121	90	168	94	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	90	168	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	90	168	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	90	168	132	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	90	168	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	90	168	149	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UT3
SERPINE1	P05121	90	168	152	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	90	168	166	169	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	168	233	166	169	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	168	233	170	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:9PAI
SERPINE1	P05121	168	233	176	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G8R
SERPINE1	P05121	168	233	186	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	168	233	204	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CVM
SERPINE1	P05121	168	233	209	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
SERPINE1	P05121	168	233	216	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C5G
SERPINE1	P05121	168	233	219	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LJ5
PAIP2B	Q9ULR5	46	105	1	123	Chain	ID=PRO_0000317294;Note=Polyadenylate-binding protein-interacting protein 2B
PAIP2	Q9BPZ3	46	106	1	127	Chain	ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2
PAIP2	Q9BPZ3	46	106	1	127	Chain	ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2
PAIP2	Q9BPZ3	46	106	1	127	Chain	ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2
PAIP2	Q9BPZ3	46	106	22	75	Region	Note=PABPC1-interacting motif-1 (PAM1)
PAIP2	Q9BPZ3	46	106	22	75	Region	Note=PABPC1-interacting motif-1 (PAM1)
PAIP2	Q9BPZ3	46	106	22	75	Region	Note=PABPC1-interacting motif-1 (PAM1)
PAIP2	Q9BPZ3	46	106	105	120	Region	Note=PABPC1-interacting motif-2 (PAM2)
PAIP2	Q9BPZ3	46	106	105	120	Region	Note=PABPC1-interacting motif-2 (PAM2)
PAIP2	Q9BPZ3	46	106	105	120	Region	Note=PABPC1-interacting motif-2 (PAM2)
PAIP2	Q9BPZ3	46	106	33	72	Compositional bias	Note=Glu-rich
PAIP2	Q9BPZ3	46	106	33	72	Compositional bias	Note=Glu-rich
PAIP2	Q9BPZ3	46	106	33	72	Compositional bias	Note=Glu-rich
PAIP2	Q9BPZ3	46	106	98	98	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAIP2	Q9BPZ3	46	106	98	98	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAIP2	Q9BPZ3	46	106	98	98	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAK6	Q9NQU5	581	626	1	681	Chain	ID=PRO_0000086476;Note=Serine/threonine-protein kinase PAK 6
PAK6	Q9NQU5	581	626	1	681	Chain	ID=PRO_0000086476;Note=Serine/threonine-protein kinase PAK 6
PAK6	Q9NQU5	581	626	1	681	Chain	ID=PRO_0000086476;Note=Serine/threonine-protein kinase PAK 6
PAK6	Q9NQU5	581	626	407	658	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PAK6	Q9NQU5	581	626	407	658	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PAK6	Q9NQU5	581	626	407	658	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PAK6	Q9NQU5	581	626	583	627	Alternative sequence	ID=VSP_056733;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PAK6	Q9NQU5	581	626	583	627	Alternative sequence	ID=VSP_056733;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PAK6	Q9NQU5	581	626	583	627	Alternative sequence	ID=VSP_056733;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PAK6	Q9NQU5	581	626	581	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	581	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	581	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	600	603	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	600	603	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	600	603	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	606	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	606	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	606	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	624	626	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	624	626	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK6	Q9NQU5	581	626	624	626	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KS7
PAK2	Q13177	450	496	2	524	Chain	ID=PRO_0000086465;Note=Serine/threonine-protein kinase PAK 2
PAK2	Q13177	450	496	213	524	Chain	ID=PRO_0000304923;Note=PAK-2p34
PAK2	Q13177	450	496	249	499	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
OPCML	Q14982	133	175	28	322	Chain	ID=PRO_0000015118;Note=Opioid-binding protein/cell adhesion molecule
OPCML	Q14982	133	175	136	219	Domain	Note=Ig-like C2-type 2
OPCML	Q14982	133	175	140	140	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
OPCML	Q14982	133	175	157	202	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
OPCML	Q14982	133	175	127	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6
OPCML	Q14982	133	175	145	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6
OPCML	Q14982	133	175	153	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6
OPCML	Q14982	133	175	166	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6
OSER1	Q9NX31	26	63	1	292	Chain	ID=PRO_0000079453;Note=Oxidative stress-responsive serine-rich protein 1
OSER1	Q9NX31	26	63	1	292	Chain	ID=PRO_0000079453;Note=Oxidative stress-responsive serine-rich protein 1
OSMR	Q99650	588	623	28	979	Chain	ID=PRO_0000259759;Note=Oncostatin-M-specific receptor subunit beta
OSMR	Q99650	588	623	28	740	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSMR	Q99650	588	623	529	623	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
OSMR	Q99650	588	623	343	979	Alternative sequence	ID=VSP_021528;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OSMR	Q99650	588	623	618	618	Natural variant	ID=VAR_043513;Note=In PLCA1. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18179886;Dbxref=dbSNP:rs63750560,PMID:18179886
OSBPL5	Q9H0X9	573	603	1	879	Chain	ID=PRO_0000100373;Note=Oxysterol-binding protein-related protein 5
OSBPL5	Q9H0X9	134	202	1	879	Chain	ID=PRO_0000100373;Note=Oxysterol-binding protein-related protein 5
OSBPL5	Q9H0X9	134	202	126	243	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
OSBPL5	Q9H0X9	134	202	134	201	Alternative sequence	ID=VSP_043071;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OSBPL5	Q9H0X9	134	202	161	201	Alternative sequence	ID=VSP_057409;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OSBPL8	Q9BZF1	609	639	1	889	Chain	ID=PRO_0000100378;Note=Oxysterol-binding protein-related protein 8
PACSIN2	Q9UNF0	343	383	1	486	Chain	ID=PRO_0000161795;Note=Protein kinase C and casein kinase substrate in neurons protein 2
PACSIN2	Q9UNF0	343	383	1	486	Chain	ID=PRO_0000161795;Note=Protein kinase C and casein kinase substrate in neurons protein 2
PACSIN2	Q9UNF0	343	383	1	486	Chain	ID=PRO_0000161795;Note=Protein kinase C and casein kinase substrate in neurons protein 2
PACSIN2	Q9UNF0	343	383	362	364	Motif	Note=NPF1
PACSIN2	Q9UNF0	343	383	362	364	Motif	Note=NPF1
PACSIN2	Q9UNF0	343	383	362	364	Motif	Note=NPF1
PACSIN2	Q9UNF0	343	383	344	384	Alternative sequence	ID=VSP_004517;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.6;Dbxref=PMID:11230166
PACSIN2	Q9UNF0	343	383	344	384	Alternative sequence	ID=VSP_004517;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.6;Dbxref=PMID:11230166
PACSIN2	Q9UNF0	343	383	344	384	Alternative sequence	ID=VSP_004517;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.6;Dbxref=PMID:11230166
PACSIN2	Q9UNF0	343	383	378	380	Sequence conflict	Note=DDT->EDI;Ontology_term=ECO:0000305;evidence=ECO:0000305
PACSIN2	Q9UNF0	343	383	378	380	Sequence conflict	Note=DDT->EDI;Ontology_term=ECO:0000305;evidence=ECO:0000305
PACSIN2	Q9UNF0	343	383	378	380	Sequence conflict	Note=DDT->EDI;Ontology_term=ECO:0000305;evidence=ECO:0000305
PACS2	Q86VP3	69	99	1	889	Chain	ID=PRO_0000259511;Note=Phosphofurin acidic cluster sorting protein 2
PACS2	Q86VP3	247	267	1	889	Chain	ID=PRO_0000259511;Note=Phosphofurin acidic cluster sorting protein 2
PACS2	Q86VP3	467	502	1	889	Chain	ID=PRO_0000259511;Note=Phosphofurin acidic cluster sorting protein 2
PACS2	Q86VP3	812	850	1	889	Chain	ID=PRO_0000259511;Note=Phosphofurin acidic cluster sorting protein 2
PACS2	Q86VP3	247	267	240	247	Alternative sequence	ID=VSP_030294;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PACS2	Q86VP3	467	502	467	467	Alternative sequence	ID=VSP_021409;Note=In isoform 2. Q->QVQLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9628581;Dbxref=PMID:9628581
PACS2	Q86VP3	467	502	493	493	Natural variant	ID=VAR_053798;Note=L->S;Dbxref=dbSNP:rs4076933
PACS2	Q86VP3	247	267	266	266	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PACS2	Q86VP3	467	502	469	469	Sequence conflict	Note=P->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAK1	Q13153	471	517	2	545	Chain	ID=PRO_0000086460;Note=Serine/threonine-protein kinase PAK 1
PAK1	Q13153	471	517	270	521	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PAK1	Q13153	471	517	515	515	Natural variant	ID=VAR_051654;Note=L->V;Dbxref=dbSNP:rs35345144
PAK1	Q13153	471	517	503	503	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAK1	Q13153	471	517	469	479	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FXZ
PAK1	Q13153	471	517	487	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FXZ
PAK1	Q13153	471	517	492	501	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FXZ
PAK1	Q13153	471	517	506	508	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FXZ
PAK1	Q13153	471	517	512	515	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FXZ
PDZRN3	Q9UPQ7	472	506	1	1066	Chain	ID=PRO_0000055917;Note=E3 ubiquitin-protein ligase PDZRN3
PDZRN3	Q9UPQ7	241	270	1	1066	Chain	ID=PRO_0000055917;Note=E3 ubiquitin-protein ligase PDZRN3
PDZRN3	Q9UPQ7	241	270	249	339	Domain	Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PDZRN3	Q9UPQ7	472	506	419	503	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PDZRN3	Q9UPQ7	472	506	361	1066	Alternative sequence	ID=VSP_012607;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDZRN3	Q9UPQ7	241	270	245	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UHP
PDZRN3	Q9UPQ7	241	270	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UHP
PDZRN3	Q9UPQ7	241	270	260	264	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UHP
PDZRN3	Q9UPQ7	472	506	469	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WH1
PDZRN3	Q9UPQ7	472	506	481	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WH1
PDZRN3	Q9UPQ7	472	506	498	502	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WH1
CRYZ	Q08257	210	244	2	329	Chain	ID=PRO_0000160906;Note=Quinone oxidoreductase
CRYZ	Q08257	160	210	2	329	Chain	ID=PRO_0000160906;Note=Quinone oxidoreductase
CRYZ	Q08257	210	244	2	329	Chain	ID=PRO_0000160906;Note=Quinone oxidoreductase
CRYZ	Q08257	160	210	2	329	Chain	ID=PRO_0000160906;Note=Quinone oxidoreductase
CRYZ	Q08257	160	210	158	161	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	160	210	158	161	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	160	210	181	181	Binding site	Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	160	210	181	181	Binding site	Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	160	210	200	200	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	160	210	200	200	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	210	244	229	229	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	210	244	229	229	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17
CRYZ	Q08257	210	244	211	244	Alternative sequence	ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CRYZ	Q08257	210	244	211	244	Alternative sequence	ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CRYZ	Q08257	160	210	176	176	Natural variant	ID=VAR_022914;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3819946
CRYZ	Q08257	160	210	176	176	Natural variant	ID=VAR_022914;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3819946
CRYZ	Q08257	160	210	183	183	Natural variant	ID=VAR_048200;Note=E->K;Dbxref=dbSNP:rs17095822
CRYZ	Q08257	160	210	183	183	Natural variant	ID=VAR_048200;Note=E->K;Dbxref=dbSNP:rs17095822
CRYZ	Q08257	160	210	160	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	160	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	183	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	183	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	195	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	195	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	205	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	205	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	205	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	160	210	205	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	226	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	226	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	237	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
CRYZ	Q08257	210	244	237	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5
QRICH1	Q2TAL8	103	446	1	776	Chain	ID=PRO_0000269853;Note=Glutamine-rich protein 1
QRICH1	Q2TAL8	103	446	1	776	Chain	ID=PRO_0000269853;Note=Glutamine-rich protein 1
QRICH1	Q2TAL8	103	446	1	776	Chain	ID=PRO_0000269853;Note=Glutamine-rich protein 1
QRICH1	Q2TAL8	103	446	85	462	Compositional bias	Note=Gln-rich
QRICH1	Q2TAL8	103	446	85	462	Compositional bias	Note=Gln-rich
QRICH1	Q2TAL8	103	446	85	462	Compositional bias	Note=Gln-rich
QRICH1	Q2TAL8	103	446	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
QRICH1	Q2TAL8	103	446	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
QRICH1	Q2TAL8	103	446	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
QRICH1	Q2TAL8	103	446	353	353	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
QRICH1	Q2TAL8	103	446	353	353	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
QRICH1	Q2TAL8	103	446	353	353	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
QRICH1	Q2TAL8	103	446	358	358	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
QRICH1	Q2TAL8	103	446	358	358	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
QRICH1	Q2TAL8	103	446	358	358	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
QRICH1	Q2TAL8	103	446	251	251	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
QRICH1	Q2TAL8	103	446	251	251	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
QRICH1	Q2TAL8	103	446	251	251	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
QRICH2	Q9H0J4	1439	1472	1	1663	Chain	ID=PRO_0000295814;Note=Glutamine-rich protein 2
QRICH2	Q9H0J4	1439	1472	1376	1609	Alternative sequence	ID=VSP_027103;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PANK1	Q8TE04	437	495	1	598	Chain	ID=PRO_0000161802;Note=Pantothenate kinase 1
PANK1	Q8TE04	437	495	438	496	Alternative sequence	ID=VSP_004521;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11809413;Dbxref=PMID:11809413
PANK1	Q8TE04	437	495	429	437	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	440	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	456	465	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	468	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	472	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	475	479	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	484	486	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
PANK1	Q8TE04	437	495	492	495	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7N
QSOX1	O00391	251	295	30	747	Chain	ID=PRO_0000249533;Note=Sulfhydryl oxidase 1
QSOX1	O00391	339	380	30	747	Chain	ID=PRO_0000249533;Note=Sulfhydryl oxidase 1
QSOX1	O00391	429	489	30	747	Chain	ID=PRO_0000249533;Note=Sulfhydryl oxidase 1
QSOX1	O00391	429	489	396	503	Domain	Note=ERV/ALR sulfhydryl oxidase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00654
QSOX1	O00391	429	489	478	485	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20211621;Dbxref=PMID:20211621
QSOX1	O00391	429	489	451	451	Binding site	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20211621;Dbxref=PMID:20211621
QSOX1	O00391	429	489	455	455	Binding site	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20211621;Dbxref=PMID:20211621
QSOX1	O00391	429	489	449	452	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00654,ECO:0000269|PubMed:20211621;Dbxref=PMID:20211621
QSOX1	O00391	251	295	256	256	Natural variant	ID=VAR_027431;Note=R->M;Dbxref=dbSNP:rs4360492
QSOX1	O00391	251	295	294	294	Natural variant	ID=VAR_027432;Note=A->S;Dbxref=dbSNP:rs2278943
QSOX1	O00391	429	489	444	444	Natural variant	ID=VAR_027433;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16806532;Dbxref=dbSNP:rs12371,PMID:16806532
QSOX1	O00391	429	489	449	449	Mutagenesis	Note=Reduces activity by 96%25. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18393449;Dbxref=PMID:18393449
QSOX1	O00391	429	489	452	452	Mutagenesis	Note=Loss of activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18393449;Dbxref=PMID:18393449
QSOX1	O00391	251	295	252	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q6O
QSOX1	O00391	251	295	256	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q6O
QSOX1	O00391	339	380	324	340	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	339	380	345	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	339	380	363	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	339	380	368	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	339	380	380	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	429	489	426	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLI
QSOX1	O00391	429	489	432	434	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	429	489	435	446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	429	489	450	463	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	429	489	464	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
QSOX1	O00391	429	489	470	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLK
PANK3	Q9H999	312	354	1	370	Chain	ID=PRO_0000161804;Note=Pantothenate kinase 3
PANK3	Q9H999	212	270	1	370	Chain	ID=PRO_0000161804;Note=Pantothenate kinase 3
PANK3	Q9H999	312	354	335	335	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PANK3	Q9H999	212	270	204	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	215	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	231	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	243	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	247	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	250	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	259	262	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	212	270	267	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	286	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	316	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	322	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	328	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	342	344	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	347	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PANK3	Q9H999	312	354	352	355	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KPR
PARP6	Q2NL67	375	397	1	630	Chain	ID=PRO_0000252430;Note=Poly [ADP-ribose] polymerase 6
PARP6	Q2NL67	333	375	1	630	Chain	ID=PRO_0000252430;Note=Poly [ADP-ribose] polymerase 6
PARP6	Q2NL67	375	397	1	630	Chain	ID=PRO_0000252430;Note=Poly [ADP-ribose] polymerase 6
PARP6	Q2NL67	333	375	1	630	Chain	ID=PRO_0000252430;Note=Poly [ADP-ribose] polymerase 6
PARP6	Q2NL67	375	397	394	620	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP6	Q2NL67	375	397	394	620	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP6	Q2NL67	375	397	373	388	Alternative sequence	ID=VSP_020963;Note=In isoform 3. NPKKKNYERLQKALDS->MVELDPRTTPHSDGPD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARP6	Q2NL67	333	375	373	388	Alternative sequence	ID=VSP_020963;Note=In isoform 3. NPKKKNYERLQKALDS->MVELDPRTTPHSDGPD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARP6	Q2NL67	375	397	373	388	Alternative sequence	ID=VSP_020963;Note=In isoform 3. NPKKKNYERLQKALDS->MVELDPRTTPHSDGPD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARP6	Q2NL67	333	375	373	388	Alternative sequence	ID=VSP_020963;Note=In isoform 3. NPKKKNYERLQKALDS->MVELDPRTTPHSDGPD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARP6	Q2NL67	375	397	389	630	Alternative sequence	ID=VSP_020964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARP6	Q2NL67	375	397	389	630	Alternative sequence	ID=VSP_020964;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARP6	Q2NL67	375	397	388	388	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP6	Q2NL67	375	397	388	388	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
DGCR2	P98153	386	465	21	550	Chain	ID=PRO_0000021484;Note=Integral membrane protein DGCR2/IDD
DGCR2	P98153	267	335	21	550	Chain	ID=PRO_0000021484;Note=Integral membrane protein DGCR2/IDD
DGCR2	P98153	208	267	21	550	Chain	ID=PRO_0000021484;Note=Integral membrane protein DGCR2/IDD
DGCR2	P98153	26	67	21	550	Chain	ID=PRO_0000021484;Note=Integral membrane protein DGCR2/IDD
DGCR2	P98153	267	335	21	349	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGCR2	P98153	208	267	21	349	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGCR2	P98153	26	67	21	349	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGCR2	P98153	386	465	369	550	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGCR2	P98153	26	67	28	68	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
DGCR2	P98153	208	267	115	241	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
DGCR2	P98153	267	335	270	333	Domain	Note=VWFC
DGCR2	P98153	26	67	30	44	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DGCR2	P98153	26	67	37	57	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DGCR2	P98153	26	67	51	66	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DGCR2	P98153	208	267	145	265	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DGCR2	P98153	208	267	233	257	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DGCR2	P98153	26	67	26	66	Alternative sequence	ID=VSP_042886;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DGCR2	P98153	267	335	315	327	Alternative sequence	ID=VSP_057188;Note=In isoform 3. QGCQQYRKDPKEC->HGCSPLSCTARAT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19906316;Dbxref=PMID:19906316
DGCR2	P98153	386	465	328	550	Alternative sequence	ID=VSP_057189;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19906316;Dbxref=PMID:19906316
DGCR2	P98153	267	335	328	550	Alternative sequence	ID=VSP_057189;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19906316;Dbxref=PMID:19906316
HSPB11	Q9Y547	68	91	1	144	Chain	ID=PRO_0000058531;Note=Intraflagellar transport protein 25 homolog
HSPB11	Q9Y547	68	91	45	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TVG
HSPB11	Q9Y547	68	91	79	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TVG
HSPB11	Q9Y547	68	91	86	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TVG
IFT52	Q9Y366	138	161	1	437	Chain	ID=PRO_0000084167;Note=Intraflagellar transport protein 52 homolog
IFT52	Q9Y366	204	233	1	437	Chain	ID=PRO_0000084167;Note=Intraflagellar transport protein 52 homolog
IFT52	Q9Y366	233	256	1	437	Chain	ID=PRO_0000084167;Note=Intraflagellar transport protein 52 homolog
IFT52	Q9Y366	138	161	1	437	Chain	ID=PRO_0000084167;Note=Intraflagellar transport protein 52 homolog
IFT52	Q9Y366	204	233	1	437	Chain	ID=PRO_0000084167;Note=Intraflagellar transport protein 52 homolog
IFT52	Q9Y366	233	256	1	437	Chain	ID=PRO_0000084167;Note=Intraflagellar transport protein 52 homolog
IFT52	Q9Y366	138	161	149	150	Sequence conflict	Note=PG->LA;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFT52	Q9Y366	138	161	149	150	Sequence conflict	Note=PG->LA;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFT52	Q9Y366	233	256	235	235	Sequence conflict	Note=V->VV;Ontology_term=ECO:0000305;evidence=ECO:0000305
IFT52	Q9Y366	233	256	235	235	Sequence conflict	Note=V->VV;Ontology_term=ECO:0000305;evidence=ECO:0000305
INTS6	Q9UL03	298	349	1	887	Chain	ID=PRO_0000259543;Note=Integrator complex subunit 6
INTS6	Q9UL03	204	246	1	887	Chain	ID=PRO_0000259543;Note=Integrator complex subunit 6
INTS6	Q9UL03	113	143	1	887	Chain	ID=PRO_0000259543;Note=Integrator complex subunit 6
INTS6	Q9UL03	63	113	1	887	Chain	ID=PRO_0000259543;Note=Integrator complex subunit 6
INTS6	Q9UL03	204	246	3	227	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
INTS6	Q9UL03	113	143	3	227	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
INTS6	Q9UL03	63	113	3	227	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
INTS6	Q9UL03	113	143	114	115	Alternative sequence	ID=VSP_021457;Note=In isoform 2. GR->VG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS6	Q9UL03	298	349	116	887	Alternative sequence	ID=VSP_021458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS6	Q9UL03	204	246	116	887	Alternative sequence	ID=VSP_021458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
INTS6	Q9UL03	113	143	116	887	Alternative sequence	ID=VSP_021458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IQUB	Q8NA54	586	669	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	470	527	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	289	341	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	132	177	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	586	669	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	470	527	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	289	341	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	132	177	1	791	Chain	ID=PRO_0000274601;Note=IQ and ubiquitin-like domain-containing protein
IQUB	Q8NA54	132	177	131	207	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
IQUB	Q8NA54	132	177	131	207	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
IQUB	Q8NA54	289	341	338	367	Domain	Note=IQ
IQUB	Q8NA54	289	341	338	367	Domain	Note=IQ
IQUB	Q8NA54	586	669	587	680	Alternative sequence	ID=VSP_022830;Note=In isoform 2. VPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKRESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENI->MGGEYLSMAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IQUB	Q8NA54	586	669	587	680	Alternative sequence	ID=VSP_022830;Note=In isoform 2. VPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKRESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENI->MGGEYLSMAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IQUB	Q8NA54	132	177	131	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	131	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	138	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	138	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	150	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	150	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	154	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	154	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	169	171	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	169	171	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	172	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQUB	Q8NA54	132	177	172	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DAF
IQGAP1	P46940	726	783	2	1657	Chain	ID=PRO_0000056648;Note=Ras GTPase-activating-like protein IQGAP1
IQGAP1	P46940	1416	1487	2	1657	Chain	ID=PRO_0000056648;Note=Ras GTPase-activating-like protein IQGAP1
IQGAP1	P46940	1543	1583	2	1657	Chain	ID=PRO_0000056648;Note=Ras GTPase-activating-like protein IQGAP1
IQGAP1	P46940	726	783	745	774	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP1	P46940	726	783	775	804	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
IQGAP1	P46940	1416	1487	1276	1657	Region	Note=C2
IQGAP1	P46940	1543	1583	1276	1657	Region	Note=C2
IQGAP1	P46940	1416	1487	1441	1441	Modified residue	Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15695813;Dbxref=PMID:15695813
IQGAP1	P46940	1416	1487	1443	1443	Modified residue	Note=Phosphoserine%3B by PKC/PRKCE;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15355962,ECO:0000269|PubMed:15695813;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:15355962,PMID:15695813
IQGAP1	P46940	1416	1487	1441	1441	Mutagenesis	Note=Abolishes neurite outgrowth promoting activity%3B when associated with A-1443. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15695813;Dbxref=PMID:15695813
IQGAP1	P46940	1416	1487	1441	1441	Mutagenesis	Note=Strongly enhances neurite outgrowth promoting activity%3B when associated with A-1443. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15695813;Dbxref=PMID:15695813
IQGAP1	P46940	1416	1487	1443	1443	Mutagenesis	Note=Abolishes neurite outgrowth promoting activity%3B when associated with A-1441. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15695813;Dbxref=PMID:15695813
IQGAP1	P46940	1416	1487	1443	1443	Mutagenesis	Note=Strongly enhances neurite outgrowth promoting activity%3B when associated with A-1441. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15695813;Dbxref=PMID:15695813
IQGAP1	P46940	1543	1583	1561	1564	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0H
IQGAP1	P46940	1543	1583	1565	1571	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0H
IQGAP1	P46940	1543	1583	1572	1577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0H
IQGAP1	P46940	1543	1583	1583	1587	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X0H
ITGA2	P17301	976	1013	30	1181	Chain	ID=PRO_0000016233;Note=Integrin alpha-2
ITGA2	P17301	1086	1116	30	1181	Chain	ID=PRO_0000016233;Note=Integrin alpha-2
ITGA2	P17301	976	1013	30	1132	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2	P17301	1086	1116	30	1132	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITIH2	P19823	53	64	19	54	Propeptide	ID=PRO_0000016517
ITIH2	P19823	53	64	55	702	Chain	ID=PRO_0000016518;Note=Inter-alpha-trypsin inhibitor heavy chain H2
ITIH2	P19823	121	155	55	702	Chain	ID=PRO_0000016518;Note=Inter-alpha-trypsin inhibitor heavy chain H2
ITIH2	P19823	210	246	55	702	Chain	ID=PRO_0000016518;Note=Inter-alpha-trypsin inhibitor heavy chain H2
ITIH2	P19823	487	549	55	702	Chain	ID=PRO_0000016518;Note=Inter-alpha-trypsin inhibitor heavy chain H2
ITIH2	P19823	652	698	55	702	Chain	ID=PRO_0000016518;Note=Inter-alpha-trypsin inhibitor heavy chain H2
ITIH2	P19823	698	736	55	702	Chain	ID=PRO_0000016518;Note=Inter-alpha-trypsin inhibitor heavy chain H2
ITIH2	P19823	698	736	703	946	Propeptide	ID=PRO_0000016519
ITIH2	P19823	53	64	56	185	Domain	Note=VIT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00801
ITIH2	P19823	121	155	56	185	Domain	Note=VIT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00801
ITIH2	P19823	652	698	665	679	Region	Note=O-glycosylated at three sites
ITIH2	P19823	53	64	60	60	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:26091039;Dbxref=PMID:24275569,PMID:26091039
ITIH2	P19823	698	736	702	702	Modified residue	Note=Aspartate 1-(chondroitin 4-sulfate)-ester
ITIH2	P19823	652	698	666	666	Glycosylation	ID=CAR_000214;Note=O-linked (GalNAc...) threonine%3B partial;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9425062,ECO:0000269|PubMed:9677337;Dbxref=PMID:9425062,PMID:9677337
ITIH2	P19823	652	698	673	673	Glycosylation	ID=CAR_000215;Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9425062,ECO:0000269|PubMed:9677337;Dbxref=PMID:9425062,PMID:9677337
ITIH2	P19823	652	698	675	675	Glycosylation	ID=CAR_000216;Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9425062,ECO:0000269|PubMed:9677337;Dbxref=PMID:9425062,PMID:9677337
ITIH2	P19823	652	698	691	691	Glycosylation	ID=CAR_000217;Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7682553,ECO:0000269|PubMed:9425062,ECO:0000269|PubMed:9677337;Dbxref=PMID:7682553,PMID:9425062,PMID:9677337
ITIH2	P19823	652	698	674	674	Natural variant	ID=VAR_055250;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2462430;Dbxref=dbSNP:rs3740217,PMID:2462430
ITIH2	P19823	698	736	705	705	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH2	P19823	698	736	705	705	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH2	P19823	698	736	729	729	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH2	P19823	698	736	729	729	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH2	P19823	698	736	731	731	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH2	P19823	698	736	731	731	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH3	Q06033	358	400	35	651	Chain	ID=PRO_0000016530;Note=Inter-alpha-trypsin inhibitor heavy chain H3
ITIH3	Q06033	461	523	35	651	Chain	ID=PRO_0000016530;Note=Inter-alpha-trypsin inhibitor heavy chain H3
ITIH3	Q06033	624	635	35	651	Chain	ID=PRO_0000016530;Note=Inter-alpha-trypsin inhibitor heavy chain H3
ITIH3	Q06033	358	400	284	467	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
ITIH3	Q06033	461	523	284	467	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
ITIH3	Q06033	358	400	361	361	Sequence conflict	Note=N->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITIH3	Q06033	461	523	515	515	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGA5	P08648	981	1022	42	1049	Chain	ID=PRO_0000016249;Note=Integrin alpha-5
ITGA5	P08648	947	981	42	1049	Chain	ID=PRO_0000016249;Note=Integrin alpha-5
ITGA5	P08648	909	947	42	1049	Chain	ID=PRO_0000016249;Note=Integrin alpha-5
ITGA5	P08648	881	909	42	1049	Chain	ID=PRO_0000016249;Note=Integrin alpha-5
ITGA5	P08648	769	795	42	1049	Chain	ID=PRO_0000016249;Note=Integrin alpha-5
ITGA5	P08648	488	521	42	1049	Chain	ID=PRO_0000016249;Note=Integrin alpha-5
ITGA5	P08648	881	909	42	894	Chain	ID=PRO_0000016250;Note=Integrin alpha-5 heavy chain
ITGA5	P08648	769	795	42	894	Chain	ID=PRO_0000016250;Note=Integrin alpha-5 heavy chain
ITGA5	P08648	488	521	42	894	Chain	ID=PRO_0000016250;Note=Integrin alpha-5 heavy chain
ITGA5	P08648	981	1022	895	1049	Chain	ID=PRO_0000016251;Note=Integrin alpha-5 light chain
ITGA5	P08648	947	981	895	1049	Chain	ID=PRO_0000016251;Note=Integrin alpha-5 light chain
ITGA5	P08648	909	947	895	1049	Chain	ID=PRO_0000016251;Note=Integrin alpha-5 light chain
ITGA5	P08648	881	909	895	1049	Chain	ID=PRO_0000016251;Note=Integrin alpha-5 light chain
ITGA5	P08648	981	1022	42	995	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	947	981	42	995	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	909	947	42	995	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	881	909	42	995	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	769	795	42	995	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	488	521	42	995	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	981	1022	996	1021	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	981	1022	1022	1049	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA5	P08648	488	521	441	504	Repeat	Note=FG-GAP 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGA5	P08648	981	1022	1021	1028	Region	Note=Interaction with HPS5
ITGA5	P08648	769	795	773	773	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:19159218,PMID:19349973
ITGA5	P08648	488	521	513	522	Disulfide bond	.
ITGA5	P08648	909	947	869	921	Disulfide bond	Note=Interchain (between heavy and light chains)
ITGA5	P08648	881	909	869	921	Disulfide bond	Note=Interchain (between heavy and light chains)
ITGA5	P08648	909	947	911	916	Disulfide bond	.
ITGA5	P08648	488	521	492	503	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VI3
ITGA5	P08648	488	521	513	520	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VI3
ITGB2	P05107	109	166	23	769	Chain	ID=PRO_0000016341;Note=Integrin beta-2
ITGB2	P05107	109	166	23	769	Chain	ID=PRO_0000016341;Note=Integrin beta-2
ITGB2	P05107	109	166	23	769	Chain	ID=PRO_0000016341;Note=Integrin beta-2
ITGB2	P05107	109	166	23	769	Chain	ID=PRO_0000016341;Note=Integrin beta-2
ITGB2	P05107	109	166	23	769	Chain	ID=PRO_0000016341;Note=Integrin beta-2
ITGB2	P05107	109	166	23	700	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB2	P05107	109	166	23	700	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB2	P05107	109	166	23	700	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB2	P05107	109	166	23	700	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB2	P05107	109	166	23	700	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB2	P05107	109	166	124	363	Domain	Note=VWFA
ITGB2	P05107	109	166	124	363	Domain	Note=VWFA
ITGB2	P05107	109	166	124	363	Domain	Note=VWFA
ITGB2	P05107	109	166	124	363	Domain	Note=VWFA
ITGB2	P05107	109	166	124	363	Domain	Note=VWFA
ITGB2	P05107	109	166	138	138	Metal binding	Note=Calcium%3B via carbonyl oxygen
ITGB2	P05107	109	166	138	138	Metal binding	Note=Calcium%3B via carbonyl oxygen
ITGB2	P05107	109	166	138	138	Metal binding	Note=Calcium%3B via carbonyl oxygen
ITGB2	P05107	109	166	138	138	Metal binding	Note=Calcium%3B via carbonyl oxygen
ITGB2	P05107	109	166	138	138	Metal binding	Note=Calcium%3B via carbonyl oxygen
ITGB2	P05107	109	166	141	141	Metal binding	Note=Calcium
ITGB2	P05107	109	166	141	141	Metal binding	Note=Calcium
ITGB2	P05107	109	166	141	141	Metal binding	Note=Calcium
ITGB2	P05107	109	166	141	141	Metal binding	Note=Calcium
ITGB2	P05107	109	166	141	141	Metal binding	Note=Calcium
ITGB2	P05107	109	166	142	142	Metal binding	Note=Calcium
ITGB2	P05107	109	166	142	142	Metal binding	Note=Calcium
ITGB2	P05107	109	166	142	142	Metal binding	Note=Calcium
ITGB2	P05107	109	166	142	142	Metal binding	Note=Calcium
ITGB2	P05107	109	166	142	142	Metal binding	Note=Calcium
ITGB2	P05107	109	166	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20033057;Dbxref=PMID:19349973,PMID:20033057
ITGB2	P05107	109	166	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20033057;Dbxref=PMID:19349973,PMID:20033057
ITGB2	P05107	109	166	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20033057;Dbxref=PMID:19349973,PMID:20033057
ITGB2	P05107	109	166	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20033057;Dbxref=PMID:19349973,PMID:20033057
ITGB2	P05107	109	166	116	116	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19349973,ECO:0000269|PubMed:20033057;Dbxref=PMID:19349973,PMID:20033057
ITGB2	P05107	109	166	33	447	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGB2	P05107	109	166	33	447	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGB2	P05107	109	166	33	447	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGB2	P05107	109	166	33	447	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGB2	P05107	109	166	33	447	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20033057;Dbxref=PMID:20033057
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_003984;Note=In LAD1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1590804;Dbxref=dbSNP:rs137852615,PMID:1590804
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_003984;Note=In LAD1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1590804;Dbxref=dbSNP:rs137852615,PMID:1590804
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_003984;Note=In LAD1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1590804;Dbxref=dbSNP:rs137852615,PMID:1590804
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_003984;Note=In LAD1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1590804;Dbxref=dbSNP:rs137852615,PMID:1590804
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_003984;Note=In LAD1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1590804;Dbxref=dbSNP:rs137852615,PMID:1590804
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_065661;Note=In LAD1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20549317;Dbxref=dbSNP:rs137852615,PMID:20549317
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_065661;Note=In LAD1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20549317;Dbxref=dbSNP:rs137852615,PMID:20549317
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_065661;Note=In LAD1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20549317;Dbxref=dbSNP:rs137852615,PMID:20549317
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_065661;Note=In LAD1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20549317;Dbxref=dbSNP:rs137852615,PMID:20549317
ITGB2	P05107	109	166	128	128	Natural variant	ID=VAR_065661;Note=In LAD1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20549317;Dbxref=dbSNP:rs137852615,PMID:20549317
ITGB2	P05107	109	166	138	138	Natural variant	ID=VAR_013402;Note=In LAD1. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9884339;Dbxref=dbSNP:rs137852617,PMID:9884339
ITGB2	P05107	109	166	138	138	Natural variant	ID=VAR_013402;Note=In LAD1. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9884339;Dbxref=dbSNP:rs137852617,PMID:9884339
ITGB2	P05107	109	166	138	138	Natural variant	ID=VAR_013402;Note=In LAD1. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9884339;Dbxref=dbSNP:rs137852617,PMID:9884339
ITGB2	P05107	109	166	138	138	Natural variant	ID=VAR_013402;Note=In LAD1. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9884339;Dbxref=dbSNP:rs137852617,PMID:9884339
ITGB2	P05107	109	166	138	138	Natural variant	ID=VAR_013402;Note=In LAD1. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9884339;Dbxref=dbSNP:rs137852617,PMID:9884339
ITGB2	P05107	109	166	149	149	Natural variant	ID=VAR_003985;Note=In LAD1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1694220;Dbxref=dbSNP:rs137852611,PMID:1694220
ITGB2	P05107	109	166	149	149	Natural variant	ID=VAR_003985;Note=In LAD1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1694220;Dbxref=dbSNP:rs137852611,PMID:1694220
ITGB2	P05107	109	166	149	149	Natural variant	ID=VAR_003985;Note=In LAD1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1694220;Dbxref=dbSNP:rs137852611,PMID:1694220
ITGB2	P05107	109	166	149	149	Natural variant	ID=VAR_003985;Note=In LAD1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1694220;Dbxref=dbSNP:rs137852611,PMID:1694220
ITGB2	P05107	109	166	149	149	Natural variant	ID=VAR_003985;Note=In LAD1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1694220;Dbxref=dbSNP:rs137852611,PMID:1694220
ITGB2	P05107	109	166	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	113	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P26
ITGB2	P05107	109	166	127	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	127	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	127	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	127	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	127	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	140	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	140	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	140	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	140	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	140	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	150	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	150	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	150	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	150	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	150	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	165	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	165	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	165	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	165	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGB2	P05107	109	166	165	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGA8	P53708	960	994	39	1063	Chain	ID=PRO_0000016310;Note=Integrin alpha-8
ITGA8	P53708	922	960	39	1063	Chain	ID=PRO_0000016310;Note=Integrin alpha-8
ITGA8	P53708	826	879	39	1063	Chain	ID=PRO_0000016310;Note=Integrin alpha-8
ITGA8	P53708	764	790	39	1063	Chain	ID=PRO_0000016310;Note=Integrin alpha-8
ITGA8	P53708	706	737	39	1063	Chain	ID=PRO_0000016310;Note=Integrin alpha-8
ITGA8	P53708	267	282	39	1063	Chain	ID=PRO_0000016310;Note=Integrin alpha-8
ITGA8	P53708	826	879	39	906	Chain	ID=PRO_0000016311;Note=Integrin alpha-8 heavy chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	764	790	39	906	Chain	ID=PRO_0000016311;Note=Integrin alpha-8 heavy chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	706	737	39	906	Chain	ID=PRO_0000016311;Note=Integrin alpha-8 heavy chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	267	282	39	906	Chain	ID=PRO_0000016311;Note=Integrin alpha-8 heavy chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	960	994	907	1063	Chain	ID=PRO_0000016312;Note=Integrin alpha-8 light chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	922	960	907	1063	Chain	ID=PRO_0000016312;Note=Integrin alpha-8 light chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	960	994	39	1012	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	922	960	39	1012	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	826	879	39	1012	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	764	790	39	1012	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	706	737	39	1012	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	267	282	39	1012	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	267	282	253	306	Repeat	Note=FG-GAP 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGA8	P53708	706	737	719	719	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	706	737	737	737	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	764	790	780	780	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	922	960	923	923	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA8	P53708	706	737	713	726	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA8	P53708	922	960	867	924	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA8	P53708	826	879	867	924	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA8	P53708	922	960	929	934	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA8	P53708	960	994	993	993	Natural variant	ID=VAR_018677;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15579315,ECO:0000269|Ref.1;Dbxref=dbSNP:rs9333241,PMID:15579315
ITGA8	P53708	960	994	994	994	Natural variant	ID=VAR_018678;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15579315,ECO:0000269|PubMed:7768999,ECO:0000269|Ref.1;Dbxref=dbSNP:rs1041135,PMID:15579315,PMID:7768999
ITGAE	P38570	1111	1148	19	1179	Chain	ID=PRO_0000016283;Note=Integrin alpha-E
ITGAE	P38570	1079	1111	19	1179	Chain	ID=PRO_0000016283;Note=Integrin alpha-E
ITGAE	P38570	1047	1079	19	1179	Chain	ID=PRO_0000016283;Note=Integrin alpha-E
ITGAE	P38570	945	970	19	1179	Chain	ID=PRO_0000016283;Note=Integrin alpha-E
ITGAE	P38570	885	918	19	1179	Chain	ID=PRO_0000016283;Note=Integrin alpha-E
ITGAE	P38570	1111	1148	179	1177	Chain	ID=PRO_0000016285;Note=Integrin alpha-E heavy chain
ITGAE	P38570	1079	1111	179	1177	Chain	ID=PRO_0000016285;Note=Integrin alpha-E heavy chain
ITGAE	P38570	1047	1079	179	1177	Chain	ID=PRO_0000016285;Note=Integrin alpha-E heavy chain
ITGAE	P38570	945	970	179	1177	Chain	ID=PRO_0000016285;Note=Integrin alpha-E heavy chain
ITGAE	P38570	885	918	179	1177	Chain	ID=PRO_0000016285;Note=Integrin alpha-E heavy chain
ITGAE	P38570	1111	1148	19	1124	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	1079	1111	19	1124	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	1047	1079	19	1124	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	945	970	19	1124	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	885	918	19	1124	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	1111	1148	1125	1147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	1111	1148	1148	1179	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	945	970	954	954	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	1047	1079	1065	1065	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	1079	1111	1096	1096	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAE	P38570	885	918	893	907	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGAE	P38570	1047	1079	1041	1057	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGAE	P38570	885	918	892	892	Natural variant	ID=VAR_020037;Note=Q->H;Dbxref=dbSNP:rs3744679
ITGAE	P38570	945	970	950	950	Natural variant	ID=VAR_034025;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10673275;Dbxref=dbSNP:rs1716,PMID:10673275
ITGB6	P18564	660	700	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	369	414	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	339	369	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	307	339	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	660	700	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	369	414	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	339	369	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	307	339	22	788	Chain	ID=PRO_0000016350;Note=Integrin beta-6
ITGB6	P18564	660	700	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	339	369	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	307	339	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	660	700	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	339	369	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	307	339	22	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	131	371	Domain	Note=VWFA
ITGB6	P18564	339	369	131	371	Domain	Note=VWFA
ITGB6	P18564	307	339	131	371	Domain	Note=VWFA
ITGB6	P18564	369	414	131	371	Domain	Note=VWFA
ITGB6	P18564	339	369	131	371	Domain	Note=VWFA
ITGB6	P18564	307	339	131	371	Domain	Note=VWFA
ITGB6	P18564	369	414	387	387	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	387	387	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	396	396	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	396	396	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB6	P18564	369	414	23	454	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	339	369	23	454	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	307	339	23	454	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	369	414	23	454	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	339	369	23	454	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	307	339	23	454	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	369	414	394	406	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	369	414	394	406	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	426	670	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	426	670	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	630	702	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	630	702	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	649	678	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	649	678	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB6	P18564	660	700	554	660	Alternative sequence	ID=VSP_055189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGB6	P18564	660	700	554	660	Alternative sequence	ID=VSP_055189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGB6	P18564	307	339	312	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	307	339	312	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	307	339	324	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	307	339	324	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	339	369	332	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	307	339	332	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	339	369	332	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	307	339	332	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	339	369	349	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	339	369	349	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	369	414	360	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	339	369	360	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	369	414	360	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	339	369	360	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
ITGB6	P18564	369	414	375	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	375	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	387	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	387	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	395	397	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM8
ITGB6	P18564	369	414	395	397	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM8
ITGB6	P18564	369	414	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	414	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITGB6	P18564	369	414	414	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
ITSN2	Q9NZM3	621	648	1	1697	Chain	ID=PRO_0000080961;Note=Intersectin-2
ITSN2	Q9NZM3	621	648	361	756	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ITSN2	Q9NZM3	621	648	622	648	Alternative sequence	ID=VSP_003892;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10574462,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:10574462,PMID:14702039
JAM2	P57087	22	44	1	28	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10779521,ECO:0000269|PubMed:15340161;Dbxref=PMID:10779521,PMID:15340161
JAM2	P57087	22	44	29	298	Chain	ID=PRO_0000015069;Note=Junctional adhesion molecule B
JAM2	P57087	44	80	29	298	Chain	ID=PRO_0000015069;Note=Junctional adhesion molecule B
JAM2	P57087	80	131	29	298	Chain	ID=PRO_0000015069;Note=Junctional adhesion molecule B
JAM2	P57087	232	268	29	298	Chain	ID=PRO_0000015069;Note=Junctional adhesion molecule B
JAM2	P57087	22	44	29	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	44	80	29	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	80	131	29	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	232	268	29	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	232	268	239	259	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	232	268	260	298	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	22	44	32	127	Domain	Note=Ig-like V-type
JAM2	P57087	44	80	32	127	Domain	Note=Ig-like V-type
JAM2	P57087	80	131	32	127	Domain	Note=Ig-like V-type
JAM2	P57087	232	268	134	238	Domain	Note=Ig-like C2-type
JAM2	P57087	80	131	98	98	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
JAM2	P57087	232	268	236	236	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
JAM2	P57087	44	80	50	109	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
JAM2	P57087	80	131	50	109	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
JAM2	P57087	22	44	44	79	Alternative sequence	ID=VSP_045153;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
JAM2	P57087	44	80	44	79	Alternative sequence	ID=VSP_045153;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
JAKMIP2	Q96AA8	714	782	1	810	Chain	ID=PRO_0000050762;Note=Janus kinase and microtubule-interacting protein 2
JAKMIP2	Q96AA8	688	714	1	810	Chain	ID=PRO_0000050762;Note=Janus kinase and microtubule-interacting protein 2
JAKMIP2	Q96AA8	538	559	1	810	Chain	ID=PRO_0000050762;Note=Janus kinase and microtubule-interacting protein 2
JAKMIP2	Q96AA8	427	467	1	810	Chain	ID=PRO_0000050762;Note=Janus kinase and microtubule-interacting protein 2
JAKMIP2	Q96AA8	312	361	1	810	Chain	ID=PRO_0000050762;Note=Janus kinase and microtubule-interacting protein 2
JAKMIP2	Q96AA8	209	279	1	810	Chain	ID=PRO_0000050762;Note=Janus kinase and microtubule-interacting protein 2
JAKMIP2	Q96AA8	209	279	207	244	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP2	Q96AA8	312	361	280	419	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP2	Q96AA8	538	559	468	597	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP2	Q96AA8	714	782	664	808	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP2	Q96AA8	688	714	664	808	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
JAKMIP2	Q96AA8	538	559	539	559	Alternative sequence	ID=VSP_002430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9628581;Dbxref=PMID:9628581
JAKMIP2	Q96AA8	312	361	315	315	Natural variant	ID=VAR_035930;Note=In a colorectal cancer sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs761359853,PMID:16959974
MAPK8IP1	Q9UQF2	69	174	1	711	Chain	ID=PRO_0000220628;Note=C-Jun-amino-terminal kinase-interacting protein 1
MAPK8IP1	Q9UQF2	655	687	1	711	Chain	ID=PRO_0000220628;Note=C-Jun-amino-terminal kinase-interacting protein 1
MAPK8IP1	Q9UQF2	655	687	561	700	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
MAPK8IP1	Q9UQF2	69	174	127	285	Region	Note=JNK-binding domain (JBD)
MAPK8IP1	Q9UQF2	69	174	157	176	Region	Note=Minimal inhibitory domain (MID)
MAPK8IP1	Q9UQF2	655	687	471	660	Region	Note=Interaction with VRK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18286207;Dbxref=PMID:18286207
MAPK8IP1	Q9UQF2	69	174	79	84	Compositional bias	Note=Poly-Gly
MAPK8IP1	Q9UQF2	69	174	107	116	Compositional bias	Note=Asp/Glu-rich (acidic)
MAPK8IP1	Q9UQF2	69	174	103	103	Modified residue	Note=Phosphothreonine%3B by MAPK8%2C MAPK9 and MAPK10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12756254;Dbxref=PMID:12756254
MAPK8IP1	Q9UQF2	69	174	152	152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16195223;Dbxref=PMID:16195223
MAPK8IP1	Q9UQF2	69	174	160	160	Mutagenesis	Note=Abolishes MAPK9 interaction. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12756254;Dbxref=PMID:12756254
MAPK8IP1	Q9UQF2	69	174	161	161	Mutagenesis	Note=Abolishes MAPK9 interaction. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12756254;Dbxref=PMID:12756254
JOSD2	Q8TAC2	49	90	1	188	Chain	ID=PRO_0000053843;Note=Josephin-2
JOSD2	Q8TAC2	49	90	1	188	Chain	ID=PRO_0000053843;Note=Josephin-2
JOSD2	Q8TAC2	49	90	11	188	Domain	Note=Josephin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00331
JOSD2	Q8TAC2	49	90	11	188	Domain	Note=Josephin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00331
JOSD2	Q8TAC2	49	90	49	90	Alternative sequence	ID=VSP_047537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
JOSD2	Q8TAC2	49	90	49	90	Alternative sequence	ID=VSP_047537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MMRN1	Q13201	283	318	20	1228	Chain	ID=PRO_0000007821;Note=Multimerin-1
MMRN1	Q13201	376	1039	20	1228	Chain	ID=PRO_0000007821;Note=Multimerin-1
MMRN1	Q13201	283	318	20	1228	Chain	ID=PRO_0000007821;Note=Multimerin-1
MMRN1	Q13201	376	1039	20	1228	Chain	ID=PRO_0000007821;Note=Multimerin-1
MMRN1	Q13201	283	318	184	1228	Chain	ID=PRO_0000367047;Note=Platelet glycoprotein Ia*
MMRN1	Q13201	376	1039	184	1228	Chain	ID=PRO_0000367047;Note=Platelet glycoprotein Ia*
MMRN1	Q13201	283	318	184	1228	Chain	ID=PRO_0000367047;Note=Platelet glycoprotein Ia*
MMRN1	Q13201	376	1039	184	1228	Chain	ID=PRO_0000367047;Note=Platelet glycoprotein Ia*
MMRN1	Q13201	283	318	318	1228	Chain	ID=PRO_0000367048;Note=155 kDa platelet multimerin
MMRN1	Q13201	376	1039	318	1228	Chain	ID=PRO_0000367048;Note=155 kDa platelet multimerin
MMRN1	Q13201	283	318	318	1228	Chain	ID=PRO_0000367048;Note=155 kDa platelet multimerin
MMRN1	Q13201	376	1039	318	1228	Chain	ID=PRO_0000367048;Note=155 kDa platelet multimerin
MMRN1	Q13201	376	1039	400	430	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	400	430	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	503	523	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	503	523	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	580	650	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	580	650	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	675	726	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	675	726	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	819	869	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	819	869	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	283	318	309	313	Compositional bias	Note=Poly-Gln
MMRN1	Q13201	283	318	309	313	Compositional bias	Note=Poly-Gln
MMRN1	Q13201	376	1039	431	431	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	431	431	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	507	507	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	507	507	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	541	541	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	541	541	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	576	576	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	576	576	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	618	618	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
MMRN1	Q13201	376	1039	618	618	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
MMRN1	Q13201	376	1039	680	680	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	680	680	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	729	729	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
MMRN1	Q13201	376	1039	729	729	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
MMRN1	Q13201	376	1039	783	783	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	783	783	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	816	816	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	816	816	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	828	828	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	828	828	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	840	840	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	840	840	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	921	921	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	921	921	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	933	933	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	933	933	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	942	942	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
MMRN1	Q13201	376	1039	942	942	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
MMRN1	Q13201	376	1039	981	981	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	981	981	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN1	Q13201	376	1039	1020	1020	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
MMRN1	Q13201	376	1039	1020	1020	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
MMRN1	Q13201	376	1039	377	1039	Alternative sequence	ID=VSP_036611;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MMRN1	Q13201	376	1039	377	1039	Alternative sequence	ID=VSP_036611;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MMRN1	Q13201	376	1039	805	805	Natural variant	ID=VAR_031472;Note=T->A;Dbxref=dbSNP:rs3756065
MMRN1	Q13201	376	1039	805	805	Natural variant	ID=VAR_031472;Note=T->A;Dbxref=dbSNP:rs3756065
MMRN1	Q13201	376	1039	883	883	Natural variant	ID=VAR_031473;Note=G->D;Dbxref=dbSNP:rs12646270
MMRN1	Q13201	376	1039	883	883	Natural variant	ID=VAR_031473;Note=G->D;Dbxref=dbSNP:rs12646270
MMRN1	Q13201	376	1039	964	964	Natural variant	ID=VAR_031474;Note=T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855885,PMID:15489334
MMRN1	Q13201	376	1039	964	964	Natural variant	ID=VAR_031474;Note=T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855885,PMID:15489334
MMRN1	Q13201	376	1039	982	982	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMRN1	Q13201	376	1039	982	982	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH6A1	Q02252	408	468	34	535	Chain	ID=PRO_0000007189;Note=Methylmalonate-semialdehyde dehydrogenase [acylating]%2C mitochondrial
ALDH6A1	Q02252	142	243	34	535	Chain	ID=PRO_0000007189;Note=Methylmalonate-semialdehyde dehydrogenase [acylating]%2C mitochondrial
ALDH6A1	Q02252	37	62	34	535	Chain	ID=PRO_0000007189;Note=Methylmalonate-semialdehyde dehydrogenase [acylating]%2C mitochondrial
ALDH6A1	Q02252	142	243	209	213	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALDH6A1	Q02252	408	468	417	417	Binding site	Note=NAD;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALDH6A1	Q02252	37	62	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQ20
ALDH6A1	Q02252	37	62	47	47	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQ20
ALDH6A1	Q02252	37	62	52	52	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQ20
ALDH6A1	Q02252	37	62	52	52	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQ20
ALDH6A1	Q02252	37	62	55	55	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQ20
ALDH6A1	Q02252	37	62	55	55	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQ20
ALDH6A1	Q02252	408	468	446	446	Natural variant	ID=VAR_010244;Note=In MMSDHD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10947204;Dbxref=dbSNP:rs72552258,PMID:10947204
ALDH6A1	Q02252	142	243	212	212	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH6A1	Q02252	408	468	460	460	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
AK8	Q96MA6	374	400	1	479	Chain	ID=PRO_0000279383;Note=Adenylate kinase 8
AK8	Q96MA6	296	326	1	479	Chain	ID=PRO_0000279383;Note=Adenylate kinase 8
AK8	Q96MA6	296	326	325	327	Nucleotide binding	Note=AMP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK8	Q96MA6	374	400	269	471	Region	Note=Adenylate kinase 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21080915;Dbxref=PMID:21080915
AK8	Q96MA6	296	326	269	471	Region	Note=Adenylate kinase 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21080915;Dbxref=PMID:21080915
AK8	Q96MA6	296	326	298	327	Region	Note=NMPbind 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK8	Q96MA6	374	400	391	424	Region	Note=LID 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK8	Q96MA6	374	400	392	392	Binding site	Note=ATP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK5	Q9Y6K8	82	138	1	562	Chain	ID=PRO_0000158930;Note=Adenylate kinase isoenzyme 5
AK5	Q9Y6K8	233	297	1	562	Chain	ID=PRO_0000158930;Note=Adenylate kinase isoenzyme 5
AK5	Q9Y6K8	367	382	1	562	Chain	ID=PRO_0000158930;Note=Adenylate kinase isoenzyme 5
AK5	Q9Y6K8	437	476	1	562	Chain	ID=PRO_0000158930;Note=Adenylate kinase isoenzyme 5
AK5	Q9Y6K8	476	540	1	562	Chain	ID=PRO_0000158930;Note=Adenylate kinase isoenzyme 5
AK5	Q9Y6K8	437	476	462	465	Nucleotide binding	Note=AMP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	82	138	133	316	Region	Note=Adenylate kinase 1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19647735;Dbxref=PMID:19647735
AK5	Q9Y6K8	233	297	133	316	Region	Note=Adenylate kinase 1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19647735;Dbxref=PMID:19647735
AK5	Q9Y6K8	233	297	256	266	Region	Note=LID 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	367	382	377	559	Region	Note=Adenylate kinase 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19647735;Dbxref=PMID:19647735
AK5	Q9Y6K8	437	476	377	559	Region	Note=Adenylate kinase 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19647735;Dbxref=PMID:19647735
AK5	Q9Y6K8	476	540	377	559	Region	Note=Adenylate kinase 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19647735;Dbxref=PMID:19647735
AK5	Q9Y6K8	476	540	499	509	Region	Note=LID 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8
AK5	Q9Y6K8	233	297	257	257	Binding site	Note=ATP 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	233	297	263	263	Binding site	Note=AMP 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	233	297	274	274	Binding site	Note=AMP 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	437	476	469	469	Binding site	Note=AMP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	476	540	500	500	Binding site	Note=ATP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	476	540	517	517	Binding site	Note=AMP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00568
AK5	Q9Y6K8	82	138	1	365	Alternative sequence	ID=VSP_037878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10215863,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:10215863,PMID:15489334
AK5	Q9Y6K8	233	297	1	365	Alternative sequence	ID=VSP_037878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10215863,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:10215863,PMID:15489334
AK5	Q9Y6K8	437	476	465	465	Natural variant	ID=VAR_059435;Note=R->Q;Dbxref=dbSNP:rs2803140
AK5	Q9Y6K8	82	138	86	86	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AK5	Q9Y6K8	367	382	369	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	367	382	378	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	437	476	437	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	437	476	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	437	476	467	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	476	540	467	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	476	540	481	487	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	476	540	490	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	476	540	507	535	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
AK5	Q9Y6K8	476	540	536	542	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BWJ
ITGA1	P56199	924	953	29	1179	Chain	ID=PRO_0000174215;Note=Integrin alpha-1
ITGA1	P56199	1060	1095	29	1179	Chain	ID=PRO_0000174215;Note=Integrin alpha-1
ITGA1	P56199	1095	1126	29	1179	Chain	ID=PRO_0000174215;Note=Integrin alpha-1
ITGA1	P56199	924	953	29	1141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1060	1095	29	1141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1095	1126	29	1141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	924	953	939	939	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1060	1095	1073	1073	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1060	1095	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1095	1126	1102	1102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1095	1126	1113	1113	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA1	P56199	1060	1095	1030	1062	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA1	P56199	1060	1095	1065	1072	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA1	P56199	1095	1126	1108	1108	Natural variant	ID=VAR_034024;Note=E->G;Dbxref=dbSNP:rs988574
ITGA2B	P08514	981	1020	32	1039	Chain	ID=PRO_0000016275;Note=Integrin alpha-IIb
ITGA2B	P08514	947	981	32	1039	Chain	ID=PRO_0000016275;Note=Integrin alpha-IIb
ITGA2B	P08514	867	909	32	1039	Chain	ID=PRO_0000016275;Note=Integrin alpha-IIb
ITGA2B	P08514	584	626	32	1039	Chain	ID=PRO_0000016275;Note=Integrin alpha-IIb
ITGA2B	P08514	223	266	32	1039	Chain	ID=PRO_0000016275;Note=Integrin alpha-IIb
ITGA2B	P08514	867	909	32	887	Chain	ID=PRO_0000016276;Note=Integrin alpha-IIb heavy chain
ITGA2B	P08514	584	626	32	887	Chain	ID=PRO_0000016276;Note=Integrin alpha-IIb heavy chain
ITGA2B	P08514	223	266	32	887	Chain	ID=PRO_0000016276;Note=Integrin alpha-IIb heavy chain
ITGA2B	P08514	981	1020	891	1039	Chain	ID=PRO_0000292348;Note=Integrin alpha-IIb light chain%2C form 1
ITGA2B	P08514	947	981	891	1039	Chain	ID=PRO_0000292348;Note=Integrin alpha-IIb light chain%2C form 1
ITGA2B	P08514	867	909	891	1039	Chain	ID=PRO_0000292348;Note=Integrin alpha-IIb light chain%2C form 1
ITGA2B	P08514	981	1020	903	1039	Chain	ID=PRO_0000016277;Note=Integrin alpha-IIb light chain%2C form 2
ITGA2B	P08514	947	981	903	1039	Chain	ID=PRO_0000016277;Note=Integrin alpha-IIb light chain%2C form 2
ITGA2B	P08514	867	909	903	1039	Chain	ID=PRO_0000016277;Note=Integrin alpha-IIb light chain%2C form 2
ITGA2B	P08514	981	1020	32	993	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	947	981	32	993	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	867	909	32	993	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	584	626	32	993	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	223	266	32	993	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	981	1020	994	1019	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	981	1020	1020	1039	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2B	P08514	223	266	187	238	Repeat	Note=FG-GAP 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGA2B	P08514	223	266	251	305	Repeat	Note=FG-GAP 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGA2B	P08514	867	909	891	891	Modified residue	Note=Pyrrolidone carboxylic acid%3B in light chain form 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2226834;Dbxref=PMID:2226834
ITGA2B	P08514	584	626	601	601	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:2775232;Dbxref=PMID:16335952,PMID:2775232
ITGA2B	P08514	867	909	874	874	Glycosylation	Note=O-linked (GalNAc...) serine%3B in variant S-874
ITGA2B	P08514	867	909	878	878	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7688323;Dbxref=PMID:7688323
ITGA2B	P08514	947	981	962	962	Glycosylation	Note=N-linked (GlcNAc...) asparagine
ITGA2B	P08514	867	909	857	911	Disulfide bond	Note=Interchain (between heavy and light chains);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2775232;Dbxref=PMID:2775232
ITGA2B	P08514	981	1020	910	1039	Alternative sequence	ID=VSP_002736;Note=In isoform 3. SCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE->VSRLSGLWPGLPGTHGAEGMGGGRGVRVCCGPLWATLGPWEHFK;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGA2B	P08514	947	981	910	1039	Alternative sequence	ID=VSP_002736;Note=In isoform 3. SCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE->VSRLSGLWPGLPGTHGAEGMGGGRGVRVCCGPLWATLGPWEHFK;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGA2B	P08514	981	1020	948	981	Alternative sequence	ID=VSP_002737;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGA2B	P08514	947	981	948	981	Alternative sequence	ID=VSP_002737;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGA2B	P08514	584	626	596	596	Natural variant	ID=VAR_030460;Note=In GT%3B type I. I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20020534,ECO:0000269|PubMed:9215749,ECO:0000269|PubMed:9734640;Dbxref=dbSNP:rs76811038,PMID:20020534,PMID:9215749,PMID:9734640
ITGA2B	P08514	867	909	874	874	Natural variant	ID=VAR_003983;Note=Alloantigen HPA-3B. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs5911,PMID:10391209
ITGA2B	P08514	947	981	957	957	Natural variant	ID=VAR_069918;Note=In GT%3B severe type 1 phenotype%3B the mutation prevented normal ITGA2B/ITGB3 complex expression on the cell surface%3B the mutation may interfere with correct folding of the protein. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20020534;Dbxref=dbSNP:rs80002943,PMID:20020534
ITGA2B	P08514	947	981	968	968	Natural variant	ID=VAR_014177;Note=Y->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs5914,PMID:10391209
ITGA2B	P08514	981	1020	982	982	Natural variant	ID=VAR_030466;Note=In GT%3B much reduced surface expression of alpha-IIb/beta-3 and a block in the maturation of pro-alpha-IIb. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15099289,ECO:0000269|PubMed:20020534;Dbxref=dbSNP:rs78657866,PMID:15099289,PMID:20020534
ITGA2B	P08514	981	1020	989	989	Natural variant	ID=VAR_030467;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15099289,ECO:0000269|PubMed:20020534;Dbxref=dbSNP:rs78165611,PMID:15099289,PMID:20020534
ITGA2B	P08514	947	981	971	971	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGA2B	P08514	223	266	225	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T3P
ITGA2B	P08514	223	266	231	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T3P
ITGA2B	P08514	223	266	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T3P
ITGA2B	P08514	584	626	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	584	626	596	603	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	584	626	616	619	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	584	626	622	627	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	867	909	906	909	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	947	981	952	965	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	947	981	967	969	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	981	1020	977	988	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	947	981	977	988	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCS
ITGA2B	P08514	981	1020	991	994	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KNC
ITGA2B	P08514	981	1020	997	1020	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K1A
MKLN1	Q9UL63	391	465	2	735	Chain	ID=PRO_0000119138;Note=Muskelin
MKLN1	Q9UL63	391	465	339	391	Repeat	Note=Kelch 2
MKLN1	Q9UL63	391	465	408	458	Repeat	Note=Kelch 3
MKLN1	Q9UL63	391	465	408	408	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKLN1	Q9UL63	391	465	414	414	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKLN1	Q9UL63	391	465	436	436	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKNK1	Q9BUB5	256	321	1	465	Chain	ID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1	Q9BUB5	164	205	1	465	Chain	ID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1	Q9BUB5	256	321	49	374	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK1	Q9BUB5	164	205	49	374	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK1	Q9BUB5	164	205	165	205	Alternative sequence	ID=VSP_007352;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15350534,ECO:0000303|PubMed:9155018;Dbxref=PMID:15350534,PMID:9155018
MKNK1	Q9BUB5	256	321	308	308	Natural variant	ID=VAR_040803;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55791614,PMID:17344846
MKNK1	Q9BUB5	256	321	271	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW6
MKNK1	Q9BUB5	256	321	277	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW6
ITIH6	Q6UXX5	1117	1243	24	1313	Chain	ID=PRO_0000285680;Note=Inter-alpha-trypsin inhibitor heavy chain H6
ITIH6	Q6UXX5	262	301	24	1313	Chain	ID=PRO_0000285680;Note=Inter-alpha-trypsin inhibitor heavy chain H6
ITIH6	Q6UXX5	262	301	283	469	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
ITIH6	Q6UXX5	1117	1243	1192	1195	Compositional bias	Note=Poly-Ala
ITIH6	Q6UXX5	1117	1243	1231	1231	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITIH6	Q6UXX5	1117	1243	1170	1170	Natural variant	ID=VAR_032045;Note=G->A;Dbxref=dbSNP:rs35355718
MKNK2	Q9HBH9	250	315	1	465	Chain	ID=PRO_0000086336;Note=MAP kinase-interacting serine/threonine-protein kinase 2
MKNK2	Q9HBH9	250	315	1	465	Chain	ID=PRO_0000086336;Note=MAP kinase-interacting serine/threonine-protein kinase 2
MKNK2	Q9HBH9	250	315	84	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK2	Q9HBH9	250	315	84	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK2	Q9HBH9	250	315	299	299	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	299	299	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	311	311	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	311	311	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	314	314	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	314	314	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	261	261	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKNK2	Q9HBH9	250	315	261	261	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKNK2	Q9HBH9	250	315	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	259	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	259	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	267	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	267	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	273	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	273	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	276	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	276	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
ITGA9	Q13797	299	345	30	1035	Chain	ID=PRO_0000016316;Note=Integrin alpha-9
ITGA9	Q13797	563	613	30	1035	Chain	ID=PRO_0000016316;Note=Integrin alpha-9
ITGA9	Q13797	811	847	30	1035	Chain	ID=PRO_0000016316;Note=Integrin alpha-9
ITGA9	Q13797	847	889	30	1035	Chain	ID=PRO_0000016316;Note=Integrin alpha-9
ITGA9	Q13797	889	929	30	1035	Chain	ID=PRO_0000016316;Note=Integrin alpha-9
ITGA9	Q13797	963	1003	30	1035	Chain	ID=PRO_0000016316;Note=Integrin alpha-9
ITGA9	Q13797	299	345	30	981	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	563	613	30	981	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	811	847	30	981	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	847	889	30	981	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	889	929	30	981	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	963	1003	30	981	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	963	1003	982	1002	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	963	1003	1003	1035	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	299	345	290	349	Repeat	Note=FG-GAP 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGA9	Q13797	299	345	312	320	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	563	613	565	566	Site	Note=Cleavage;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	563	613	612	612	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	847	889	854	854	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	889	929	904	904	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA9	Q13797	847	889	855	891	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA9	Q13797	889	929	855	891	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGA9	Q13797	889	929	898	903	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGAD	Q13349	989	1015	18	1161	Chain	ID=PRO_0000016296;Note=Integrin alpha-D
ITGAD	Q13349	1087	1124	18	1161	Chain	ID=PRO_0000016296;Note=Integrin alpha-D
ITGAD	Q13349	989	1015	18	1099	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAD	Q13349	1087	1124	18	1099	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAD	Q13349	1087	1124	1100	1120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAD	Q13349	1087	1124	1121	1161	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAD	Q13349	989	1015	993	1017	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGAM	P11215	499	569	17	1152	Chain	ID=PRO_0000016289;Note=Integrin alpha-M
ITGAM	P11215	956	992	17	1152	Chain	ID=PRO_0000016289;Note=Integrin alpha-M
ITGAM	P11215	499	569	17	1104	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAM	P11215	956	992	17	1104	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAM	P11215	499	569	443	503	Repeat	Note=FG-GAP 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGAM	P11215	499	569	506	564	Repeat	Note=FG-GAP 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGAM	P11215	499	569	569	629	Repeat	Note=FG-GAP 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGAM	P11215	499	569	529	537	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAM	P11215	956	992	978	978	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAM	P11215	499	569	499	499	Alternative sequence	ID=VSP_047365;Note=In isoform 2. G->GQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:2457584,ECO:0000303|PubMed:2563162;Dbxref=PMID:2457584,PMID:2563162
ITGAM	P11215	956	992	965	965	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGB8	P26012	267	320	43	769	Chain	ID=PRO_0000016354;Note=Integrin beta-8
ITGB8	P26012	382	427	43	769	Chain	ID=PRO_0000016354;Note=Integrin beta-8
ITGB8	P26012	267	320	43	684	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB8	P26012	382	427	43	684	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB8	P26012	267	320	146	384	Domain	Note=VWFA
ITGB8	P26012	382	427	146	384	Domain	Note=VWFA
ITGB8	P26012	382	427	402	402	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB8	P26012	382	427	421	421	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB8	P26012	267	320	47	469	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PIRSR:PIRSR002512-1
ITGB8	P26012	382	427	47	469	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PIRSR:PIRSR002512-1
ITGB8	P26012	267	320	266	307	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PIRSR:PIRSR002512-1
ITGB8	P26012	382	427	407	419	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PIRSR:PIRSR002512-1
KRT80	Q6KB66	277	319	1	452	Chain	ID=PRO_0000314896;Note=Keratin%2C type II cytoskeletal 80
KRT80	Q6KB66	190	222	1	452	Chain	ID=PRO_0000314896;Note=Keratin%2C type II cytoskeletal 80
KRT80	Q6KB66	277	319	83	394	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT80	Q6KB66	190	222	83	394	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT80	Q6KB66	190	222	136	227	Region	Note=Coil 1B
KRT80	Q6KB66	277	319	252	390	Region	Note=Coil 2
KRT80	Q6KB66	190	222	190	190	Alternative sequence	ID=VSP_030422;Note=In isoform 3. K->KVACPACPRGSFLMGPGPSFPPDILLSFMPNQSPQRLKSQDQQTDRGIPPSPSSSFFEALSQISSGITPTLTQEAAPQPTPALGPSIPSPTTHHCCQPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
MND1	Q9BWT6	92	117	2	205	Chain	ID=PRO_0000318081;Note=Meiotic nuclear division protein 1 homolog
MND1	Q9BWT6	155	170	2	205	Chain	ID=PRO_0000318081;Note=Meiotic nuclear division protein 1 homolog
MND1	Q9BWT6	92	117	84	173	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MND1	Q9BWT6	155	170	84	173	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
KAT2B	Q92831	583	620	1	832	Chain	ID=PRO_0000211208;Note=Histone acetyltransferase KAT2B
KAT2B	Q92831	583	620	503	651	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q92830,ECO:0000255|PROSITE-ProRule:PRU00532
KAT2B	Q92831	583	620	581	587	Region	Note=Acetyl-CoA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10393169;Dbxref=PMID:10393169
KAT2B	Q92831	583	620	612	615	Region	Note=Acetyl-CoA binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10393169;Dbxref=PMID:10393169
KAT2B	Q92831	583	620	582	584	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM0
KAT2B	Q92831	583	620	585	599	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM0
KAT2B	Q92831	583	620	604	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM0
KAT2B	Q92831	583	620	611	613	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM0
KAT2B	Q92831	583	620	614	618	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM0
KAT2B	Q92831	583	620	619	621	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CM0
KCNAB3	O43448	179	208	1	404	Chain	ID=PRO_0000148750;Note=Voltage-gated potassium channel subunit beta-3
CSNK1G3	Q9Y6M4	362	394	1	447	Chain	ID=PRO_0000192846;Note=Casein kinase I isoform gamma-3
CSNK1G3	Q9Y6M4	362	394	363	394	Alternative sequence	ID=VSP_010256;Note=In isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
KCTD20	Q7Z5Y7	219	285	1	419	Chain	ID=PRO_0000255248;Note=BTB/POZ domain-containing protein KCTD20
KCTD20	Q7Z5Y7	285	322	1	419	Chain	ID=PRO_0000255248;Note=BTB/POZ domain-containing protein KCTD20
KCTD20	Q7Z5Y7	219	285	55	220	Alternative sequence	ID=VSP_021278;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KCNN4	O15554	53	85	1	427	Chain	ID=PRO_0000155017;Note=Intermediate conductance calcium-activated potassium channel protein 4
KCNN4	O15554	53	85	59	79	Transmembrane	Note=Helical%3B Name%3DSegment S2;Ontology_term=ECO:0000255;evidence=ECO:0000255
KCNN4	O15554	53	85	66	66	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCNN4	O15554	53	85	51	56	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CNM
KCNN4	O15554	53	85	57	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CNM
ORC5	O43913	346	383	1	435	Chain	ID=PRO_0000127092;Note=Origin recognition complex subunit 5
ORC5	O43913	330	346	1	435	Chain	ID=PRO_0000127092;Note=Origin recognition complex subunit 5
ORC5	O43913	55	122	1	435	Chain	ID=PRO_0000127092;Note=Origin recognition complex subunit 5
ORC5	O43913	346	383	294	435	Alternative sequence	ID=VSP_042037;Note=In isoform 2. LSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYDFL->IRGSIETVTGDTSSANYQDTKVNTKEHSVRK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9765232;Dbxref=PMID:9765232
ORC5	O43913	330	346	294	435	Alternative sequence	ID=VSP_042037;Note=In isoform 2. LSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYDFL->IRGSIETVTGDTSSANYQDTKVNTKEHSVRK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9765232;Dbxref=PMID:9765232
ORC5	O43913	55	122	58	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC5	O43913	55	122	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC5	O43913	55	122	69	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC5	O43913	55	122	100	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC5	O43913	55	122	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC5	O43913	55	122	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC5	O43913	55	122	120	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
OSBPL1A	Q9BXW6	698	733	1	950	Chain	ID=PRO_0000100367;Note=Oxysterol-binding protein-related protein 1
OSBPL1A	Q9BXW6	637	697	1	950	Chain	ID=PRO_0000100367;Note=Oxysterol-binding protein-related protein 1
OSBPL1A	Q9BXW6	559	604	1	950	Chain	ID=PRO_0000100367;Note=Oxysterol-binding protein-related protein 1
OSBPL1A	Q9BXW6	69	94	1	950	Chain	ID=PRO_0000100367;Note=Oxysterol-binding protein-related protein 1
OSBPL1A	Q9BXW6	69	94	47	76	Repeat	Note=ANK 1
OSBPL1A	Q9BXW6	69	94	80	109	Repeat	Note=ANK 2
OSBPL1A	Q9BXW6	69	94	1	237	Region	Note=Interaction with RAB7A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16176980;Dbxref=PMID:16176980
OSBPL1A	Q9BXW6	69	94	1	513	Alternative sequence	ID=VSP_003779;Note=In isoform A. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11279184,ECO:0000303|PubMed:11735225,ECO:0000303|PubMed:14702039;Dbxref=PMID:11279184,PMID:11735225,PMID:14702039
OSBPL1A	Q9BXW6	69	94	1	382	Alternative sequence	ID=VSP_045443;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PALMD	Q9NP74	171	537	1	551	Chain	ID=PRO_0000262528;Note=Palmdelphin
PALMD	Q9NP74	171	537	450	459	Compositional bias	Note=Poly-Glu
PALMD	Q9NP74	171	537	271	271	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHU2
PALMD	Q9NP74	171	537	321	321	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PALMD	Q9NP74	171	537	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHU2
PALMD	Q9NP74	171	537	384	384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PALMD	Q9NP74	171	537	385	385	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JHU2
PALMD	Q9NP74	171	537	498	498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PALMD	Q9NP74	171	537	515	515	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18220336;Dbxref=PMID:18220336
PALMD	Q9NP74	171	537	520	520	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PALMD	Q9NP74	171	537	179	179	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
PALMD	Q9NP74	171	537	179	179	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PALMD	Q9NP74	171	537	1	175	Alternative sequence	ID=VSP_021786;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PALMD	Q9NP74	171	537	229	229	Natural variant	ID=VAR_053806;Note=N->S;Dbxref=dbSNP:rs35258980
PALMD	Q9NP74	171	537	459	459	Natural variant	ID=VAR_053807;Note=E->D;Dbxref=dbSNP:rs35317701
PALMD	Q9NP74	171	537	248	248	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PALMD	Q9NP74	171	537	385	385	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PALM	O75781	167	211	1	384	Chain	ID=PRO_0000058218;Note=Paralemmin-1
PALM	O75781	167	211	168	211	Alternative sequence	ID=VSP_003918;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9615234,ECO:0000303|PubMed:9813098;Dbxref=PMID:9615234,PMID:9813098
PAN2	Q504Q3	1125	1191	1	1202	Chain	ID=PRO_0000280521;Note=PAN2-PAN3 deadenylation complex catalytic subunit PAN2
PAN2	Q504Q3	1125	1191	1	1202	Chain	ID=PRO_0000280521;Note=PAN2-PAN3 deadenylation complex catalytic subunit PAN2
PAN2	Q504Q3	1125	1191	975	1147	Domain	Note=Exonuclease;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03182
PAN2	Q504Q3	1125	1191	975	1147	Domain	Note=Exonuclease;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03182
PAN2	Q504Q3	1125	1191	1139	1139	Metal binding	Note=Divalent metal cation%3B catalytic;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:O95453,ECO:0000255|HAMAP-Rule:MF_03182
PAN2	Q504Q3	1125	1191	1139	1139	Metal binding	Note=Divalent metal cation%3B catalytic;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:O95453,ECO:0000255|HAMAP-Rule:MF_03182
PAN2	Q504Q3	1125	1191	1189	1189	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:23186163
PAN2	Q504Q3	1125	1191	1189	1189	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:23186163
QPCTL	Q9NXS2	117	211	1	382	Chain	ID=PRO_0000302002;Note=Glutaminyl-peptide cyclotransferase-like protein
QPCTL	Q9NXS2	295	334	1	382	Chain	ID=PRO_0000302002;Note=Glutaminyl-peptide cyclotransferase-like protein
QPCTL	Q9NXS2	117	211	186	186	Metal binding	Note=Zinc%3B catalytic
QPCTL	Q9NXS2	117	211	118	211	Alternative sequence	ID=VSP_054066;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
QPCTL	Q9NXS2	295	334	295	295	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
QPCTL	Q9NXS2	295	334	321	321	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
QPCTL	Q9NXS2	295	334	321	321	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
QPCTL	Q9NXS2	295	334	334	334	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
QPCTL	Q9NXS2	117	211	110	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	117	211	131	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	117	211	144	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	117	211	159	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	117	211	176	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB9
QPCTL	Q9NXS2	117	211	184	187	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	117	211	188	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	117	211	202	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	295	334	286	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	295	334	313	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	295	334	329	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCTL	Q9NXS2	295	334	333	335	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PB6
QPCT	Q16769	89	182	29	361	Chain	ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase
QPCT	Q16769	182	241	29	361	Chain	ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase
QPCT	Q16769	274	313	29	361	Chain	ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase
QPCT	Q16769	182	241	201	201	Active site	Note=Proton acceptor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18072935;Dbxref=PMID:18072935
QPCT	Q16769	89	182	159	159	Metal binding	Note=Zinc%3B catalytic
QPCT	Q16769	182	241	202	202	Metal binding	Note=Zinc%3B catalytic
QPCT	Q16769	274	313	296	296	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
QPCT	Q16769	89	182	139	164	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21671571;Dbxref=PMID:21671571
QPCT	Q16769	89	182	41	89	Alternative sequence	ID=VSP_038487;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
QPCT	Q16769	89	182	144	144	Mutagenesis	Note=Lowers activity by approximately 40%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=PMID:16135565
QPCT	Q16769	89	182	146	146	Mutagenesis	Note=Lowers activity by approximately 30%25. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=PMID:16135565
QPCT	Q16769	89	182	160	160	Mutagenesis	Note=Reduces activity by about 50%25. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18072935;Dbxref=PMID:18072935
QPCT	Q16769	89	182	160	160	Mutagenesis	Note=Reduces activity by 96%25. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18072935;Dbxref=PMID:18072935
QPCT	Q16769	182	241	201	201	Mutagenesis	Note=Reduces activity by about 98%25. E->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16135565,ECO:0000269|PubMed:18072935;Dbxref=PMID:16135565,PMID:18072935
QPCT	Q16769	182	241	201	201	Mutagenesis	Note=Abolishes activity. E->L%2CQ;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16135565,ECO:0000269|PubMed:18072935;Dbxref=PMID:16135565,PMID:18072935
QPCT	Q16769	182	241	207	207	Mutagenesis	Note=Greatly lowers activity. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=PMID:16135565
QPCT	Q16769	274	313	304	304	Mutagenesis	Note=Lowers activity by approximately 35%25. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=PMID:16135565
QPCT	Q16769	274	313	305	305	Mutagenesis	Note=Abolishes activity. D->A%2CE%2CL;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16135565,ECO:0000269|PubMed:18072935;Dbxref=PMID:16135565,PMID:18072935
QPCT	Q16769	274	313	305	305	Mutagenesis	Note=Reduces activity by 99%25. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16135565,ECO:0000269|PubMed:18072935;Dbxref=PMID:16135565,PMID:18072935
QPCT	Q16769	89	182	82	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	98	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	103	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	116	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	131	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	149	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PBB
QPCT	Q16769	89	182	157	160	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	161	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	175	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	89	182	180	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YWY
QPCT	Q16769	182	241	180	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YWY
QPCT	Q16769	182	241	191	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	182	241	204	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	182	241	209	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	182	241	214	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	182	241	226	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	182	241	237	240	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	182	241	241	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	274	313	265	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	274	313	284	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	274	313	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PBB
QPCT	Q16769	274	313	308	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
QPCT	Q16769	274	313	312	314	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW
PATE2	Q6UY27	25	68	1	26	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
PATE2	Q6UY27	25	68	27	113	Chain	ID=PRO_0000263607;Note=Prostate and testis expressed protein 2
PATE2	Q6UY27	25	68	29	110	Domain	Note=UPAR/Ly6;Ontology_term=ECO:0000305;evidence=ECO:0000305
PATE2	Q6UY27	25	68	31	57	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PATE2	Q6UY27	25	68	34	42	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PATE2	Q6UY27	25	68	49	80	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PATE2	Q6UY27	25	68	26	68	Alternative sequence	ID=VSP_035810;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PXN	P49023	277	311	1	591	Chain	ID=PRO_0000075853;Note=Paxillin
PXN	P49023	277	311	303	303	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PXN	P49023	277	311	278	311	Alternative sequence	ID=VSP_003114;Note=In isoform Alpha and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:7534286;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005,PMID:7534286
PXN	P49023	277	311	278	311	Alternative sequence	ID=VSP_003115;Note=In isoform Gamma. IQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGG->GSWPLEEVVLLVSISSSVQEGEKYPHPCAARHRTPSLRSPDQPPPCPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9054445;Dbxref=PMID:9054445
PXN	P49023	277	311	280	280	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP1	P09874	835	886	2	1014	Chain	ID=PRO_0000211320;Note=Poly [ADP-ribose] polymerase 1
PARP1	P09874	802	835	2	1014	Chain	ID=PRO_0000211320;Note=Poly [ADP-ribose] polymerase 1
PARP1	P09874	647	690	2	1014	Chain	ID=PRO_0000211320;Note=Poly [ADP-ribose] polymerase 1
PARP1	P09874	647	690	662	779	Domain	Note=PARP alpha-helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00398
PARP1	P09874	835	886	788	1014	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP1	P09874	802	835	788	1014	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP1	P09874	835	886	868	868	Mutagenesis	Note=4%25 of wild-type activity. N->S
PARP1	P09874	802	835	827	827	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP1	P09874	647	690	667	676	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	647	690	679	688	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	802	835	799	803	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	802	835	806	808	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RCW
PARP1	P09874	802	835	809	820	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	802	835	824	826	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WS1
PARP1	P09874	835	886	829	841	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	802	835	829	841	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	835	886	844	848	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	835	886	849	853	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	835	886	857	864	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	835	886	866	868	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	835	886	869	875	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PARP1	P09874	835	886	882	884	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WOK
PARP1	P09874	835	886	886	888	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZZ
PCF11	O94913	1472	1484	2	1555	Chain	ID=PRO_0000058246;Note=Pre-mRNA cleavage complex 2 protein Pcf11
PCDH19	Q8TAB3	716	762	22	1148	Chain	ID=PRO_0000004003;Note=Protocadherin-19
PCDH19	Q8TAB3	716	762	700	1148	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCDH19	Q8TAB3	716	762	716	762	Alternative sequence	ID=VSP_015081;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:17974005;Dbxref=PMID:10718198,PMID:17974005
PCDH19	Q8TAB3	716	762	158	1148	Natural variant	ID=VAR_078722;Note=In EIEE9. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25818041;Dbxref=PMID:25818041
PCCA	P05165	35	61	1	52	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16023992;Dbxref=PMID:16023992
PCCA	P05165	35	61	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	156	200	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	355	403	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	428	451	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	476	513	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	582	615	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	615	633	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	633	680	53	728	Chain	ID=PRO_0000002837;Note=Propionyl-CoA carboxylase alpha chain%2C mitochondrial
PCCA	P05165	156	200	62	509	Domain	Note=Biotin carboxylation
PCCA	P05165	355	403	62	509	Domain	Note=Biotin carboxylation
PCCA	P05165	428	451	62	509	Domain	Note=Biotin carboxylation
PCCA	P05165	476	513	62	509	Domain	Note=Biotin carboxylation
PCCA	P05165	156	200	181	378	Domain	Note=ATP-grasp;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
PCCA	P05165	355	403	181	378	Domain	Note=ATP-grasp;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
PCCA	P05165	633	680	653	728	Domain	Note=Biotinyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066
PCCA	P05165	156	200	177	177	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PCCA	P05165	156	200	200	200	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	156	200	200	200	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	355	403	385	385	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	476	513	496	496	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	476	513	502	502	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	476	513	513	513	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	633	680	648	648	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91ZA3
PCCA	P05165	35	61	36	61	Alternative sequence	ID=VSP_039857;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCCA	P05165	633	680	634	680	Alternative sequence	ID=VSP_044458;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCCA	P05165	156	200	164	164	Natural variant	ID=VAR_009090;Note=In PA-1. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10101253;Dbxref=dbSNP:rs202247815,PMID:10101253
PCCA	P05165	156	200	197	197	Natural variant	ID=VAR_023843;Note=In PA-1. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15059621;Dbxref=PMID:15059621
PCCA	P05165	355	403	368	368	Natural variant	ID=VAR_009093;Note=In PA-1. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10329019;Dbxref=PMID:10329019
PCCA	P05165	355	403	373	373	Natural variant	ID=VAR_009094;Note=In PA-1%3B unstable protein. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10101253;Dbxref=dbSNP:rs121964958,PMID:10101253
PCCA	P05165	355	403	379	379	Natural variant	ID=VAR_009095;Note=In PA-1. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10329019;Dbxref=dbSNP:rs794727087,PMID:10329019
PCCA	P05165	355	403	398	398	Natural variant	ID=VAR_023844;Note=In PA-1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15059621;Dbxref=PMID:15059621
PCCA	P05165	355	403	399	399	Natural variant	ID=VAR_009096;Note=In PA-1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15059621;Dbxref=dbSNP:rs1301904623,PMID:15059621
PCCA	P05165	615	633	631	631	Natural variant	ID=VAR_009100;Note=In PA-1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10101253;Dbxref=dbSNP:rs796052018,PMID:10101253
PCCA	P05165	633	680	668	668	Natural variant	ID=VAR_009101;Note=In PA-1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10329019;Dbxref=dbSNP:rs771438170,PMID:10329019
PCCA	P05165	35	61	61	61	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCCA	P05165	355	403	373	373	Sequence conflict	Note=M->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCCA	P05165	355	403	378	379	Sequence conflict	Note=KG->RS;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCCA	P05165	582	615	610	610	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCCA	P05165	633	680	679	679	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCCA	P05165	156	200	199	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQY
PCCA	P05165	633	680	665	667	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKU
PCCA	P05165	633	680	669	673	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JKU
PCIF1	Q9H4Z3	83	129	1	704	Chain	ID=PRO_0000076087;Note=Phosphorylated CTD-interacting factor 1
PCIF1	Q9H4Z3	274	301	1	704	Chain	ID=PRO_0000076087;Note=Phosphorylated CTD-interacting factor 1
PCIF1	Q9H4Z3	83	129	109	113	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCIF1	Q9H4Z3	83	129	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163
PCYT1A	P49585	236	299	1	367	Chain	ID=PRO_0000208453;Note=Choline-phosphate cytidylyltransferase A
PCYT1A	P49585	236	299	1	367	Chain	ID=PRO_0000208453;Note=Choline-phosphate cytidylyltransferase A
PCYT1A	P49585	236	299	228	287	Region	Note=Amphipathic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCYT1A	P49585	236	299	228	287	Region	Note=Amphipathic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCYT1A	P49585	236	299	256	288	Region	Note=3 X 11 AA approximate tandem repeats
PCYT1A	P49585	236	299	256	288	Region	Note=3 X 11 AA approximate tandem repeats
PCYT1A	P49585	236	299	251	251	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCYT1A	P49585	236	299	251	251	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
ORC4	O43929	319	351	1	436	Chain	ID=PRO_0000127087;Note=Origin recognition complex subunit 4
ORC4	O43929	196	254	1	436	Chain	ID=PRO_0000127087;Note=Origin recognition complex subunit 4
ORC4	O43929	319	351	1	436	Chain	ID=PRO_0000127087;Note=Origin recognition complex subunit 4
ORC4	O43929	196	254	1	436	Chain	ID=PRO_0000127087;Note=Origin recognition complex subunit 4
ORC4	O43929	319	351	1	436	Chain	ID=PRO_0000127087;Note=Origin recognition complex subunit 4
ORC4	O43929	196	254	1	436	Chain	ID=PRO_0000127087;Note=Origin recognition complex subunit 4
ORC4	O43929	196	254	198	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	198	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	198	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	204	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	204	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	204	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	215	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	215	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	215	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	223	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	223	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	223	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	245	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	245	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	196	254	245	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	313	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	313	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	313	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	323	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	323	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	323	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	346	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	346	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
ORC4	O43929	319	351	346	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJ7
OSGEP	Q9NPF4	137	169	1	335	Chain	ID=PRO_0000096984;Note=Probable tRNA N6-adenosine threonylcarbamoyltransferase
OSGEP	Q9NPF4	38	78	1	335	Chain	ID=PRO_0000096984;Note=Probable tRNA N6-adenosine threonylcarbamoyltransferase
OSGEP	Q9NPF4	137	169	162	162	Binding site	Note=Substrate;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03180
OSGEP	Q9NPF4	38	78	78	78	Natural variant	ID=VAR_080358;Note=In GAMOS3. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28805828;Dbxref=dbSNP:rs200347983,PMID:28805828
OSGEP	Q9NPF4	137	169	139	139	Natural variant	ID=VAR_080362;Note=In GAMOS3. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28805828;Dbxref=PMID:28805828
OVGP1	Q12889	239	301	22	678	Chain	ID=PRO_0000011973;Note=Oviduct-specific glycoprotein
OTUD5	Q96G74	493	531	1	571	Chain	ID=PRO_0000278223;Note=OTU domain-containing protein 5
OTUD5	Q96G74	358	426	1	571	Chain	ID=PRO_0000278223;Note=OTU domain-containing protein 5
OTUD5	Q96G74	493	531	507	507	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22245969;Dbxref=PMID:22245969
DAO	P14920	129	150	1	347	Chain	ID=PRO_0000162761;Note=D-amino-acid oxidase
DAO	P14920	169	204	1	347	Chain	ID=PRO_0000162761;Note=D-amino-acid oxidase
DAO	P14920	169	204	182	182	Binding site	Note=FAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17088322,ECO:0000269|PubMed:18455394;Dbxref=PMID:17088322,PMID:18455394
DAO	P14920	129	150	129	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNN
DAO	P14920	129	150	141	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNN
DAO	P14920	169	204	167	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNN
DAO	P14920	169	204	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNN
DAO	P14920	169	204	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNN
DAO	P14920	169	204	196	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNN
P2RX6	O15547	186	212	1	441	Chain	ID=PRO_0000161557;Note=P2X purinoceptor 6
P2RX6	O15547	328	350	1	441	Chain	ID=PRO_0000161557;Note=P2X purinoceptor 6
P2RX6	O15547	350	376	1	441	Chain	ID=PRO_0000161557;Note=P2X purinoceptor 6
P2RX6	O15547	186	212	61	333	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX6	O15547	328	350	61	333	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX6	O15547	328	350	334	354	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX6	O15547	350	376	334	354	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX6	O15547	350	376	355	441	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX6	O15547	186	212	195	195	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX6	O15547	186	212	210	210	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P4HA2	O15460	435	457	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	301	360	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	110	156	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	435	457	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	301	360	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	110	156	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	435	457	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	301	360	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	110	156	22	535	Chain	ID=PRO_0000022726;Note=Prolyl 4-hydroxylase subunit alpha-2
P4HA2	O15460	435	457	412	520	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HA2	O15460	435	457	412	520	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HA2	O15460	435	457	412	520	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HA2	O15460	110	156	115	115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P4HA2	O15460	110	156	115	115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P4HA2	O15460	110	156	115	115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P4HA2	O15460	435	457	436	451	Alternative sequence	ID=VSP_004506;Note=In isoform IIa. NDERDTFKHLGTGNRV->RPFDSGLKTEGNRL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
P4HA2	O15460	435	457	436	451	Alternative sequence	ID=VSP_004506;Note=In isoform IIa. NDERDTFKHLGTGNRV->RPFDSGLKTEGNRL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
P4HA2	O15460	435	457	436	451	Alternative sequence	ID=VSP_004506;Note=In isoform IIa. NDERDTFKHLGTGNRV->RPFDSGLKTEGNRL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
P4HA2	O15460	110	156	140	140	Natural variant	ID=VAR_074026;Note=In MYP25. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25741866;Dbxref=dbSNP:rs764211125,PMID:25741866
P4HA2	O15460	110	156	140	140	Natural variant	ID=VAR_074026;Note=In MYP25. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25741866;Dbxref=dbSNP:rs764211125,PMID:25741866
P4HA2	O15460	110	156	140	140	Natural variant	ID=VAR_074026;Note=In MYP25. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25741866;Dbxref=dbSNP:rs764211125,PMID:25741866
P4HA2	O15460	110	156	150	150	Natural variant	ID=VAR_074027;Note=In MYP25%3B unknown pathological significance. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25741866;Dbxref=dbSNP:rs771208496,PMID:25741866
P4HA2	O15460	110	156	150	150	Natural variant	ID=VAR_074027;Note=In MYP25%3B unknown pathological significance. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25741866;Dbxref=dbSNP:rs771208496,PMID:25741866
P4HA2	O15460	110	156	150	150	Natural variant	ID=VAR_074027;Note=In MYP25%3B unknown pathological significance. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25741866;Dbxref=dbSNP:rs771208496,PMID:25741866
P4HA3	Q7Z4N8	189	239	20	544	Chain	ID=PRO_0000317766;Note=Prolyl 4-hydroxylase subunit alpha-3
P4HA3	Q7Z4N8	189	239	227	260	Repeat	Note=TPR
P4HA3	Q7Z4N8	189	239	222	222	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
P2RX1	P51575	344	378	1	399	Chain	ID=PRO_0000161545;Note=P2X purinoceptor 1
P2RX1	P51575	175	201	1	399	Chain	ID=PRO_0000161545;Note=P2X purinoceptor 1
P2RX1	P51575	95	119	1	399	Chain	ID=PRO_0000161545;Note=P2X purinoceptor 1
P2RX1	P51575	175	201	51	338	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX1	P51575	95	119	51	338	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX1	P51575	344	378	339	358	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX1	P51575	344	378	359	399	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX1	P51575	344	378	351	354	Compositional bias	Note=Poly-Leu
P2RX1	P51575	175	201	184	184	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P2RX1	P51575	95	119	117	165	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11809854;Dbxref=PMID:11809854
P2RX1	P51575	344	378	351	351	Natural variant	ID=VAR_025382;Note=In one patient presenting with severe bleeding%3B somatic mutation%3B results in a non-functional channel. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10816552;Dbxref=PMID:10816552
P2RX3	P56373	312	334	1	397	Chain	ID=PRO_0000161551;Note=P2X purinoceptor 3
P2RX3	P56373	312	334	44	322	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27626375;Dbxref=PMID:27626375
P2RX3	P56373	312	334	323	341	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27626375;Dbxref=PMID:27626375
P2RX3	P56373	312	334	293	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SVK
P2RX3	P56373	312	334	318	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SVK
P2RX3	P56373	312	334	333	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SVK
TP53I11	O14683	111	145	1	189	Chain	ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11
TP53I11	O14683	111	145	1	189	Chain	ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11
TP53I11	O14683	111	145	1	189	Chain	ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11
TP53I11	O14683	111	145	1	189	Chain	ID=PRO_0000058142;Note=Tumor protein p53-inducible protein 11
TP53I11	O14683	111	145	109	129	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	109	129	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	109	129	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	109	129	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	130	130	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	130	130	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	130	130	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	130	130	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I11	O14683	111	145	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PADI2	Q9Y2J8	176	218	1	665	Chain	ID=PRO_0000220026;Note=Protein-arginine deiminase type-2
PADI2	Q9Y2J8	176	218	177	177	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4N25,ECO:0000244|PDB:4N26,ECO:0000244|PDB:4N28,ECO:0000244|PDB:4N2A,ECO:0000244|PDB:4N2B,ECO:0000244|PDB:4N2E,ECO:0000244|PDB:4N2G,ECO:0000244|PDB:4N2L,ECO:0000244|PDB:4N2N
PADI2	Q9Y2J8	176	218	180	180	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:4N25,ECO:0000244|PDB:4N26,ECO:0000244|PDB:4N28,ECO:0000244|PDB:4N2A,ECO:0000244|PDB:4N2B,ECO:0000244|PDB:4N2E,ECO:0000244|PDB:4N2G,ECO:0000244|PDB:4N2I,ECO:0000244|PDB:4N2L,ECO:0000244|PDB:4N2N
PADI2	Q9Y2J8	176	218	180	180	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4N25,ECO:0000244|PDB:4N26,ECO:0000244|PDB:4N28,ECO:0000244|PDB:4N2A,ECO:0000244|PDB:4N2B,ECO:0000244|PDB:4N2C,ECO:0000244|PDB:4N2E,ECO:0000244|PDB:4N2G,ECO:0000244|PDB:4N2I,ECO:0000244|PDB:4N2L,ECO:0000244|PDB:4N2N,ECO:0000269|PubMed:25621824;Dbxref=PMID:25621824
PADI2	Q9Y2J8	176	218	177	177	Mutagenesis	Note=Reduced enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621824;Dbxref=PMID:25621824
PADI2	Q9Y2J8	176	218	175	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N2K
PADI2	Q9Y2J8	176	218	181	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N2K
PADI2	Q9Y2J8	176	218	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N2K
PADI2	Q9Y2J8	176	218	207	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N2K
PADI2	Q9Y2J8	176	218	212	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N2K
PLA2G7	Q13093	221	259	22	441	Chain	ID=PRO_0000017833;Note=Platelet-activating factor acetylhydrolase
PLA2G7	Q13093	221	259	22	441	Chain	ID=PRO_0000017833;Note=Platelet-activating factor acetylhydrolase
PLA2G7	Q13093	221	259	214	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D59
PLA2G7	Q13093	221	259	214	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D59
PLA2G7	Q13093	221	259	255	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D59
PLA2G7	Q13093	221	259	255	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D59
PLA2G15	Q8NCC3	134	167	34	412	Chain	ID=PRO_0000017808;Note=Group XV phospholipase A2
PLA2G15	Q8NCC3	167	242	34	412	Chain	ID=PRO_0000017808;Note=Group XV phospholipase A2
PLA2G15	Q8NCC3	167	242	198	198	Active site	Note=Acyl-ester intermediate;Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:4X97,ECO:0000255,ECO:0000269|PubMed:25727495;Dbxref=PMID:25727495
PLA2G15	Q8NCC3	167	242	199	199	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:4X95,ECO:0000305|PubMed:25727495;Dbxref=PMID:25727495
PLA2G15	Q8NCC3	134	167	115	208	Alternative sequence	ID=VSP_056690;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLA2G15	Q8NCC3	167	242	115	208	Alternative sequence	ID=VSP_056690;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLA2G15	Q8NCC3	167	242	198	198	Mutagenesis	Note=Abolishes phospholipase and transacetylase activity. Abolishes association with membranes. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25727495;Dbxref=PMID:25727495
PLA2G15	Q8NCC3	167	242	235	235	Mutagenesis	Note=No effect on phospholipase activity. Abolishes transacetylase activity. Has no effect on association with membranes. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25727495;Dbxref=PMID:25727495
PLA2G15	Q8NCC3	134	167	133	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	134	167	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	134	167	139	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	134	167	153	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	134	167	156	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	134	167	167	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	167	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	171	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	192	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	200	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	213	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
PLA2G15	Q8NCC3	167	242	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X90
QSER1	Q2KHR3	1527	1573	1	1735	Chain	ID=PRO_0000288933;Note=Glutamine and serine-rich protein 1
QSER1	Q2KHR3	1606	1657	1	1735	Chain	ID=PRO_0000288933;Note=Glutamine and serine-rich protein 1
QSER1	Q2KHR3	1657	1689	1	1735	Chain	ID=PRO_0000288933;Note=Glutamine and serine-rich protein 1
PABPC1L	Q4VXU2	246	292	1	614	Chain	ID=PRO_0000277879;Note=Polyadenylate-binding protein 1-like
PABPC1L	Q4VXU2	246	292	1	614	Chain	ID=PRO_0000277879;Note=Polyadenylate-binding protein 1-like
PABPC1L	Q4VXU2	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC1L	Q4VXU2	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PAPOLA	P51003	3	60	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	147	165	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	202	232	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	372	389	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	390	429	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	668	689	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	689	714	2	745	Chain	ID=PRO_0000051612;Note=Poly(A) polymerase alpha
PAPOLA	P51003	668	689	677	745	Region	Note=Required for interaction with NUDT21
PAPOLA	P51003	689	714	677	745	Region	Note=Required for interaction with NUDT21
PAPOLA	P51003	3	60	53	57	Compositional bias	Note=Poly-Glu
PAPOLA	P51003	202	232	228	228	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PAPOLA	P51003	147	165	153	153	Site	Note=Interaction with RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
PAPOLA	P51003	147	165	158	158	Site	Note=Interaction with RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
PAPOLA	P51003	390	429	399	399	Site	Note=Interaction with RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
PAPOLA	P51003	3	60	10	10	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PAPOLA	P51003	3	60	24	24	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
PAPOLA	P51003	372	389	286	745	Alternative sequence	ID=VSP_012896;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
PAPOLA	P51003	390	429	286	745	Alternative sequence	ID=VSP_012896;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
PAPOLA	P51003	668	689	286	745	Alternative sequence	ID=VSP_012896;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
PAPOLA	P51003	689	714	286	745	Alternative sequence	ID=VSP_012896;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
PAPOLA	P51003	3	60	2	3	Sequence conflict	Note=PF->GTSNSPGHSSFSAPSTKKIKTTRKQNIAWC;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAPOLA	P51003	202	232	204	238	Sequence conflict	Note=CRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYS->MRKPTSFCVLQFLSDISCFYTSFVLKLFIAILLTQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAPOLG	Q9BWT3	663	685	1	736	Chain	ID=PRO_0000051624;Note=Poly(A) polymerase gamma
PAPOLG	Q9BWT3	685	704	1	736	Chain	ID=PRO_0000051624;Note=Poly(A) polymerase gamma
PAPOLG	Q9BWT3	663	685	684	684	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
PAPOLG	Q9BWT3	663	685	664	685	Alternative sequence	ID=VSP_054379;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
PAPOLG	Q9BWT3	685	704	664	685	Alternative sequence	ID=VSP_054379;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8
PAPPA	Q13219	541	639	81	1627	Chain	ID=PRO_0000029246;Note=Pappalysin-1
PAPPA	Q13219	1049	1087	81	1627	Chain	ID=PRO_0000029246;Note=Pappalysin-1
PAPPA	Q13219	541	639	272	583	Region	Note=Metalloprotease
PAPPA	Q13219	541	639	563	563	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
PAPPA	Q13219	541	639	562	562	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
PAPPA	Q13219	541	639	566	566	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
PAPPA	Q13219	541	639	572	572	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10095
PAPPA	Q13219	541	639	601	601	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	541	639	619	619	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	541	639	327	622	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00302,ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	541	639	332	657	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00302,ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	541	639	583	600	Disulfide bond	Note=Or C-583 with C-612;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00302,ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	541	639	587	612	Disulfide bond	Note=Or C-587 with C-600;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00302,ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	1049	1087	1036	1070	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00302,ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PAPPA	Q13219	1049	1087	1051	1139	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00302,ECO:0000269|PubMed:12421832;Dbxref=PMID:12421832
PARP9	Q8IXQ6	496	623	1	854	Chain	ID=PRO_0000211339;Note=Poly [ADP-ribose] polymerase 9
PARP9	Q8IXQ6	496	623	517	517	Natural variant	ID=VAR_056655;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs28365795,PMID:15489334
PARP9	Q8IXQ6	496	623	528	528	Natural variant	ID=VAR_056656;Note=Y->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11110709,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs9851180,PMID:11110709,PMID:14702039,PMID:15489334
PARN	O95453	439	468	1	639	Chain	ID=PRO_0000212851;Note=Poly(A)-specific ribonuclease PARN
PARN	O95453	280	306	1	639	Chain	ID=PRO_0000212851;Note=Poly(A)-specific ribonuclease PARN
PARN	O95453	261	280	1	639	Chain	ID=PRO_0000212851;Note=Poly(A)-specific ribonuclease PARN
PARN	O95453	234	261	1	639	Chain	ID=PRO_0000212851;Note=Poly(A)-specific ribonuclease PARN
PARN	O95453	234	261	178	245	Domain	Note=R3H;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00382
PARN	O95453	280	306	292	292	Metal binding	Note=Divalent metal cation%3B catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARN	O95453	280	306	292	292	Mutagenesis	Note=Loss of function but does not abolish ability to bind RNA. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11742007,ECO:0000269|PubMed:15358788;Dbxref=PMID:11742007,PMID:15358788
PARN	O95453	280	306	292	292	Mutagenesis	Note=Loss of function in the presence of Mg(2+) but not in the presence of Mn(2+)%2C Zn(2+)%2C Co(2+) or Cd(2+). D->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11742007,ECO:0000269|PubMed:15358788;Dbxref=PMID:11742007,PMID:15358788
PARN	O95453	234	261	237	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1S
PARN	O95453	234	261	245	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1S
PARN	O95453	234	261	249	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1S
PARN	O95453	261	280	260	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1R
PARN	O95453	234	261	260	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1R
PARN	O95453	280	306	271	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1R
PARN	O95453	261	280	271	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1R
PARN	O95453	280	306	283	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1R
PARN	O95453	280	306	290	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A1R
PARN	O95453	439	468	445	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CTR
PARN	O95453	439	468	458	464	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CTR
PARN	O95453	439	468	465	467	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CTR
PARN	O95453	439	468	468	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CTR
PCGF1	Q9BSM1	117	141	2	259	Chain	ID=PRO_0000277855;Note=Polycomb group RING finger protein 1
PCGF1	Q9BSM1	117	141	86	247	Region	Note=Required for repressor activity
OPALIN	Q96PE5	13	24	1	141	Chain	ID=PRO_0000072591;Note=Opalin
OPALIN	Q96PE5	13	24	1	29	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
OPALIN	Q96PE5	13	24	14	14	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
OPALIN	Q96PE5	13	24	1	24	Alternative sequence	ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
OPALIN	Q96PE5	13	24	1	13	Alternative sequence	ID=VSP_042943;Note=In isoform 2. MSFSLNFTLPANT->MRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OPALIN	Q96PE5	13	24	13	23	Alternative sequence	ID=VSP_054892;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OPHN1	O60890	611	719	1	802	Chain	ID=PRO_0000056760;Note=Oligophrenin-1
OPHN1	O60890	199	234	1	802	Chain	ID=PRO_0000056760;Note=Oligophrenin-1
OPHN1	O60890	104	128	1	802	Chain	ID=PRO_0000056760;Note=Oligophrenin-1
OPHN1	O60890	51	83	1	802	Chain	ID=PRO_0000056760;Note=Oligophrenin-1
OPHN1	O60890	611	719	629	761	Compositional bias	Note=Pro-rich
OPHN1	O60890	611	719	312	802	Alternative sequence	ID=VSP_055337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
OPHN1	O60890	199	234	199	199	Natural variant	ID=VAR_066746;Note=In MRXSO. P->PEFSLLMNGLKIFIKCL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21796728;Dbxref=PMID:21796728
OPHN1	O60890	611	719	693	693	Natural variant	ID=VAR_033452;Note=M->I;Dbxref=dbSNP:rs36095561
PDHB	P11177	68	89	31	359	Chain	ID=PRO_0000020457;Note=Pyruvate dehydrogenase E1 component subunit beta%2C mitochondrial
PDHB	P11177	68	89	89	89	Binding site	Note=Thiamine pyrophosphate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12651851;Dbxref=PMID:12651851
PDHB	P11177	68	89	69	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZL
PDHB	P11177	68	89	73	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZL
PDHB	P11177	68	89	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZL
PDHB	P11177	68	89	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZL
PDHB	P11177	68	89	89	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OZL
OSGEPL1	Q9H4B0	365	388	30	414	Chain	ID=PRO_0000307778;Note=Probable tRNA N6-adenosine threonylcarbamoyltransferase%2C mitochondrial
OSGEPL1	Q9H4B0	365	388	30	414	Chain	ID=PRO_0000307778;Note=Probable tRNA N6-adenosine threonylcarbamoyltransferase%2C mitochondrial
OSGEPL1	Q9H4B0	365	388	299	414	Alternative sequence	ID=VSP_028829;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
OSGEPL1	Q9H4B0	365	388	299	414	Alternative sequence	ID=VSP_028829;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
OSGEPL1	Q9H4B0	365	388	365	414	Alternative sequence	ID=VSP_028830;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OSGEPL1	Q9H4B0	365	388	365	414	Alternative sequence	ID=VSP_028830;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PM20D1	Q6GTS8	348	372	26	502	Chain	ID=PRO_0000321928;Note=N-fatty-acyl-amino acid synthase/hydrolase PM20D1
PM20D1	Q6GTS8	348	372	302	361	Alternative sequence	ID=VSP_031826;Note=In isoform 2. FPFPVNIILSNPWLFEPLISRFMERNPLTNAIIRTTTALTIFKAGVKFNVIPPVAQATVN->VYGEKSLNQCNNQDHHGTHHIQSRGQVQCHPPSGPGHSQLPDSPWTDSPRGPRTHEEHCG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PM20D1	Q6GTS8	348	372	362	502	Alternative sequence	ID=VSP_031827;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3C2G	O75747	542	585	1	1445	Chain	ID=PRO_0000088799;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PIK3C2G	O75747	668	730	1	1445	Chain	ID=PRO_0000088799;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PIK3C2G	O75747	542	585	1	1445	Chain	ID=PRO_0000088799;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PIK3C2G	O75747	668	730	1	1445	Chain	ID=PRO_0000088799;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PIK3C2G	O75747	542	585	453	628	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00880
PIK3C2G	O75747	542	585	453	628	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00880
PIK3C2G	O75747	668	730	643	819	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3C2G	O75747	668	730	643	819	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3C2B	O00750	1016	1052	1	1634	Chain	ID=PRO_0000088798;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
PIK3C2B	O00750	689	744	1	1634	Chain	ID=PRO_0000088798;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
PIK3C2B	O00750	648	688	1	1634	Chain	ID=PRO_0000088798;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
PIK3C2B	O00750	522	571	1	1634	Chain	ID=PRO_0000088798;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
PIK3C2B	O00750	689	744	635	786	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041,ECO:0000255|PROSITE-ProRule:PRU00880
PIK3C2B	O00750	648	688	635	786	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041,ECO:0000255|PROSITE-ProRule:PRU00880
PIK3C2B	O00750	522	571	567	567	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIK3C2B	O00750	648	688	664	665	Sequence conflict	Note=EL->DM;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP2R3A	Q06190	665	754	1	1150	Chain	ID=PRO_0000071443;Note=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
PPP2R3A	Q06190	848	877	1	1150	Chain	ID=PRO_0000071443;Note=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
PPP2R3A	Q06190	665	754	670	695	Compositional bias	Note=Pro-rich
PPP2R3A	Q06190	665	754	1	736	Alternative sequence	ID=VSP_045203;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PPP2R3A	Q06190	665	754	622	665	Alternative sequence	ID=VSP_005108;Note=In isoform PR72. MQILQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQTPEVIK->MMIKETSLRRDPDLRGELAFLARGCDFVLPSRFKKRLKSFQQTQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8392071;Dbxref=PMID:14702039,PMID:8392071
PPP2R3A	Q06190	665	754	695	695	Natural variant	ID=VAR_051744;Note=P->L;Dbxref=dbSNP:rs9826032
PPP2R3A	Q06190	665	754	745	745	Natural variant	ID=VAR_022095;Note=D->N;Dbxref=dbSNP:rs16843645
PPP2R3A	Q06190	848	877	839	857	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I5J
PPP2R3A	Q06190	848	877	861	863	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I5K
PPP2R3A	Q06190	848	877	867	871	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I5J
PPP2R3A	Q06190	848	877	875	882	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I5J
P4HTM	Q9NXG6	296	357	1	502	Chain	ID=PRO_0000206668;Note=Transmembrane prolyl 4-hydroxylase
P4HTM	Q9NXG6	296	357	82	502	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P4HTM	Q9NXG6	296	357	310	460	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HTM	Q9NXG6	296	357	328	328	Metal binding	Note=Iron;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HTM	Q9NXG6	296	357	330	330	Metal binding	Note=Iron;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
P4HTM	Q9NXG6	296	357	348	348	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIK3R3	Q92569	339	395	1	461	Chain	ID=PRO_0000080767;Note=Phosphatidylinositol 3-kinase regulatory subunit gamma
PIK3R3	Q92569	255	313	1	461	Chain	ID=PRO_0000080767;Note=Phosphatidylinositol 3-kinase regulatory subunit gamma
PIK3R3	Q92569	339	395	1	461	Chain	ID=PRO_0000080767;Note=Phosphatidylinositol 3-kinase regulatory subunit gamma
PIK3R3	Q92569	255	313	1	461	Chain	ID=PRO_0000080767;Note=Phosphatidylinositol 3-kinase regulatory subunit gamma
PIK3R3	Q92569	339	395	1	461	Chain	ID=PRO_0000080767;Note=Phosphatidylinositol 3-kinase regulatory subunit gamma
PIK3R3	Q92569	255	313	1	461	Chain	ID=PRO_0000080767;Note=Phosphatidylinositol 3-kinase regulatory subunit gamma
PIK3R3	Q92569	339	395	358	452	Domain	Note=SH2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PIK3R3	Q92569	339	395	358	452	Domain	Note=SH2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PIK3R3	Q92569	339	395	358	452	Domain	Note=SH2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PIK3R3	Q92569	339	395	341	341	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64143
PIK3R3	Q92569	339	395	341	341	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64143
PIK3R3	Q92569	339	395	341	341	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64143
PIK3R3	Q92569	255	313	256	314	Alternative sequence	ID=VSP_004714;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9524259;Dbxref=PMID:9524259
PIK3R3	Q92569	255	313	256	314	Alternative sequence	ID=VSP_004714;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9524259;Dbxref=PMID:9524259
PIK3R3	Q92569	255	313	256	314	Alternative sequence	ID=VSP_004714;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9524259;Dbxref=PMID:9524259
PIK3R3	Q92569	255	313	283	283	Natural variant	ID=VAR_047153;Note=N->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9524259,ECO:0000269|Ref.2,ECO:0000269|Ref.5;Dbxref=dbSNP:rs785467,PMID:14702039,PMID:9524259
PIK3R3	Q92569	255	313	283	283	Natural variant	ID=VAR_047153;Note=N->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9524259,ECO:0000269|Ref.2,ECO:0000269|Ref.5;Dbxref=dbSNP:rs785467,PMID:14702039,PMID:9524259
PIK3R3	Q92569	255	313	283	283	Natural variant	ID=VAR_047153;Note=N->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9524259,ECO:0000269|Ref.2,ECO:0000269|Ref.5;Dbxref=dbSNP:rs785467,PMID:14702039,PMID:9524259
PLA2G4D	Q86XP0	560	625	1	818	Chain	ID=PRO_0000247023;Note=Cytosolic phospholipase A2 delta
PLA2G4D	Q86XP0	85	129	1	818	Chain	ID=PRO_0000247023;Note=Cytosolic phospholipase A2 delta
PLA2G4D	Q86XP0	85	129	9	120	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
PLA2G4D	Q86XP0	560	625	273	818	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4D	Q86XP0	560	625	573	573	Natural variant	ID=VAR_027049;Note=R->W;Dbxref=dbSNP:rs17747505
PLA2G4D	Q86XP0	85	129	87	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	85	129	97	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	85	129	102	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	85	129	111	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	85	129	120	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	577	579	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IXC
PLA2G4D	Q86XP0	560	625	581	583	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	584	590	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	605	608	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	610	612	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	613	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	618	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
PLA2G4D	Q86XP0	560	625	623	625	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IZ5
UQCRC1	P31930	23	70	1	34	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:8313870;Dbxref=PMID:25944712,PMID:8313870
UQCRC1	P31930	274	322	35	480	Chain	ID=PRO_0000026786;Note=Cytochrome b-c1 complex subunit 1%2C mitochondrial
UQCRC1	P31930	70	99	35	480	Chain	ID=PRO_0000026786;Note=Cytochrome b-c1 complex subunit 1%2C mitochondrial
UQCRC1	P31930	23	70	35	480	Chain	ID=PRO_0000026786;Note=Cytochrome b-c1 complex subunit 1%2C mitochondrial
UQCRC1	P31930	274	322	301	301	Natural variant	ID=VAR_013629;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10453733,ECO:0000269|PubMed:8407948;Dbxref=dbSNP:rs144710790,PMID:10453733,PMID:8407948
UQCRC1	P31930	23	70	38	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRC1	P31930	23	70	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRC1	P31930	70	99	84	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRC1	P31930	70	99	89	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRC1	P31930	70	99	96	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRC1	P31930	274	322	285	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRC1	P31930	274	322	300	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRH	P07919	27	81	14	91	Chain	ID=PRO_0000035990;Note=Cytochrome b-c1 complex subunit 6%2C mitochondrial
UQCRH	P07919	27	81	42	42	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P99028
UQCRH	P07919	27	81	37	81	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00126
UQCRH	P07919	27	81	53	67	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00126
UQCRH	P07919	27	81	51	51	Natural variant	ID=VAR_034579;Note=E->Q;Dbxref=dbSNP:rs34813470
UQCRH	P07919	27	81	57	57	Sequence conflict	Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
UQCRH	P07919	27	81	57	57	Sequence conflict	Note=V->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
UQCRH	P07919	27	81	29	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRH	P07919	27	81	41	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
UQCRH	P07919	27	81	68	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTE
CRYZL1	O95825	72	87	1	349	Chain	ID=PRO_0000160913;Note=Quinone oxidoreductase-like protein 1
CRYZL1	O95825	72	87	78	78	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TP53I3	Q53FA7	135	206	1	332	Chain	ID=PRO_0000160917;Note=Quinone oxidoreductase PIG3
TP53I3	Q53FA7	135	206	1	332	Chain	ID=PRO_0000160917;Note=Quinone oxidoreductase PIG3
TP53I3	Q53FA7	135	206	148	154	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	148	154	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	173	177	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	173	177	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	192	192	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	192	192	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	180	180	Natural variant	ID=VAR_033032;Note=In a breast cancer sample%3B somatic mutation. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=dbSNP:rs899619458,PMID:17224074
TP53I3	Q53FA7	135	206	180	180	Natural variant	ID=VAR_033032;Note=In a breast cancer sample%3B somatic mutation. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=dbSNP:rs899619458,PMID:17224074
TP53I3	Q53FA7	135	206	151	151	Mutagenesis	Note=Loss of enzyme activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	151	151	Mutagenesis	Note=Loss of enzyme activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
TP53I3	Q53FA7	135	206	133	135	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	133	135	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	152	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	152	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	167	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	167	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	175	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	175	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	187	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	187	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	192	194	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	192	194	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	197	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	197	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	205	207	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
TP53I3	Q53FA7	135	206	205	207	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
ADIPOR1	Q96A54	47	86	1	375	Chain	ID=PRO_0000218827;Note=Adiponectin receptor protein 1
ADIPOR1	Q96A54	47	86	1	136	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25855295;Dbxref=PMID:25855295
TIPARP	Q7Z3E1	416	508	1	657	Chain	ID=PRO_0000247835;Note=TCDD-inducible poly [ADP-ribose] polymerase
TIPARP	Q7Z3E1	416	508	1	657	Chain	ID=PRO_0000247835;Note=TCDD-inducible poly [ADP-ribose] polymerase
TIPARP	Q7Z3E1	416	508	1	657	Chain	ID=PRO_0000247835;Note=TCDD-inducible poly [ADP-ribose] polymerase
TIPARP	Q7Z3E1	416	508	1	657	Chain	ID=PRO_0000247835;Note=TCDD-inducible poly [ADP-ribose] polymerase
TIPARP	Q7Z3E1	416	508	449	657	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
TIPARP	Q7Z3E1	416	508	449	657	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
TIPARP	Q7Z3E1	416	508	449	657	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
TIPARP	Q7Z3E1	416	508	449	657	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARM1	Q6UWI2	14	256	1	20	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
PARM1	Q6UWI2	14	256	21	310	Chain	ID=PRO_0000045498;Note=Prostate androgen-regulated mucin-like protein 1
PARM1	Q6UWI2	14	256	21	258	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARM1	Q6UWI2	14	256	58	58	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARM1	Q6UWI2	14	256	62	62	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARM1	Q6UWI2	14	256	80	80	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19139490;Dbxref=PMID:19139490
PARM1	Q6UWI2	14	256	176	176	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARM1	Q6UWI2	14	256	127	127	Natural variant	ID=VAR_062257;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11230166;Dbxref=dbSNP:rs3822109,PMID:11230166
PARM1	Q6UWI2	14	256	82	82	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARM1	Q6UWI2	14	256	123	123	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
OGDHL	Q9ULD0	68	125	1	73	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
OGDHL	Q9ULD0	432	492	74	1010	Chain	ID=PRO_0000310983;Note=2-oxoglutarate dehydrogenase-like%2C mitochondrial
OGDHL	Q9ULD0	68	125	74	1010	Chain	ID=PRO_0000310983;Note=2-oxoglutarate dehydrogenase-like%2C mitochondrial
OGDHL	Q9ULD0	68	125	1	209	Alternative sequence	ID=VSP_041351;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OGDHL	Q9ULD0	68	125	69	125	Alternative sequence	ID=VSP_041350;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OGDHL	Q9ULD0	68	125	97	97	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
OSBPL10	Q9BXB5	638	698	1	764	Chain	ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10
OSBPL10	Q9BXB5	365	415	1	764	Chain	ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10
OSBPL10	Q9BXB5	179	243	1	764	Chain	ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10
OSBPL10	Q9BXB5	365	415	413	418	Region	Note=Phosphatidylinositol 4-phosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02201
OSBPL10	Q9BXB5	365	415	413	418	Region	Note=Phosphatidylserine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02201
OSBPL10	Q9BXB5	179	243	196	196	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
OSBPL10	Q9BXB5	179	243	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
OSBPL10	Q9BXB5	179	243	209	209	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
OSBPL10	Q9BXB5	179	243	223	223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
OSBPL10	Q9BXB5	179	243	180	243	Alternative sequence	ID=VSP_042930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC51A	Q86UW1	211	260	1	340	Chain	ID=PRO_0000331543;Note=Organic solute transporter subunit alpha
SLC51A	Q86UW1	211	260	203	218	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC51A	Q86UW1	211	260	219	239	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC51A	Q86UW1	211	260	240	255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC51A	Q86UW1	211	260	256	276	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTC	Q9NRP0	78	143	1	149	Chain	ID=PRO_0000320602;Note=Oligosaccharyltransferase complex subunit OSTC
OSTC	Q9NRP0	78	143	54	83	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTC	Q9NRP0	78	143	84	104	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTC	Q9NRP0	78	143	105	117	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTC	Q9NRP0	78	143	118	138	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTC	Q9NRP0	78	143	139	149	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
OSTC	Q9NRP0	78	143	119	119	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
OXA1L	Q15070	130	178	114	134	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
OXA1L	Q15070	130	178	135	139	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
OXA1L	Q15070	130	178	140	160	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
OXA1L	Q15070	130	178	161	212	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
OXA1L	Q15070	351	378	321	435	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
OXA1L	Q15070	351	378	364	364	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
OXA1L	Q15070	130	178	147	149	Alternative sequence	ID=VSP_008943;Note=In isoform 3. CTV->F;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
OXA1L	Q15070	351	378	266	435	Alternative sequence	ID=VSP_008945;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
OXA1L	Q15070	351	378	372	372	Mutagenesis	Note=Increases strongly homooligomer formation in presence of magnesium%2C but weakly in absence of magnesium. A->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739282;Dbxref=PMID:20739282
PIK3C2A	O00443	1107	1138	2	1686	Chain	ID=PRO_0000088795;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
PIK3C2A	O00443	1072	1107	2	1686	Chain	ID=PRO_0000088795;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
PIK3C2A	O00443	744	799	2	1686	Chain	ID=PRO_0000088795;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
PIK3C2A	O00443	703	743	2	1686	Chain	ID=PRO_0000088795;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
PIK3C2A	O00443	568	616	2	1686	Chain	ID=PRO_0000088795;Note=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
PIK3C2A	O00443	744	799	682	841	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041,ECO:0000255|PROSITE-ProRule:PRU00880
PIK3C2A	O00443	703	743	682	841	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041,ECO:0000255|PROSITE-ProRule:PRU00880
PIK3C2A	O00443	1107	1138	1133	1397	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PIK3C2A	O00443	1107	1138	484	1686	Alternative sequence	ID=VSP_056158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3C2A	O00443	1072	1107	484	1686	Alternative sequence	ID=VSP_056158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3C2A	O00443	744	799	484	1686	Alternative sequence	ID=VSP_056158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3C2A	O00443	703	743	484	1686	Alternative sequence	ID=VSP_056158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3C2A	O00443	568	616	484	1686	Alternative sequence	ID=VSP_056158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3C2A	O00443	744	799	796	796	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIK3C2A	O00443	744	799	799	799	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIK3C2A	O00443	1107	1138	1129	1129	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GATAD2A	Q86YP4	178	208	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	208	252	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	252	308	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	500	525	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	178	208	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	208	252	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	252	308	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	500	525	1	633	Chain	ID=PRO_0000083500;Note=Transcriptional repressor p66-alpha
GATAD2A	Q86YP4	178	208	144	178	Region	Note=CR1%3B MBD2-binding
GATAD2A	Q86YP4	178	208	144	178	Region	Note=CR1%3B MBD2-binding
GATAD2A	Q86YP4	178	208	189	189	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:23186163,PMID:24275569
GATAD2A	Q86YP4	178	208	189	189	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:23186163,PMID:24275569
GATAD2A	Q86YP4	208	252	225	225	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CHY6
GATAD2A	Q86YP4	208	252	225	225	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CHY6
GATAD2A	Q86YP4	208	252	249	249	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	208	252	249	249	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	252	308	258	258	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	252	308	258	258	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	252	308	273	273	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	252	308	273	273	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	252	308	275	275	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GATAD2A	Q86YP4	252	308	275	275	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GATAD2A	Q86YP4	252	308	285	285	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	252	308	285	285	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
GATAD2A	Q86YP4	500	525	512	512	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GATAD2A	Q86YP4	500	525	512	512	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GATAD2A	Q86YP4	178	208	178	178	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GATAD2A	Q86YP4	178	208	178	178	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GATAD2A	Q86YP4	178	208	204	204	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GATAD2A	Q86YP4	178	208	204	204	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GATAD2A	Q86YP4	208	252	233	233	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GATAD2A	Q86YP4	208	252	233	233	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GATAD2A	Q86YP4	500	525	500	524	Alternative sequence	ID=VSP_010929;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GATAD2A	Q86YP4	500	525	500	524	Alternative sequence	ID=VSP_010929;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
GATAD2A	Q86YP4	252	308	296	296	Natural variant	ID=VAR_059309;Note=N->S;Dbxref=dbSNP:rs2288851
GATAD2A	Q86YP4	252	308	296	296	Natural variant	ID=VAR_059309;Note=N->S;Dbxref=dbSNP:rs2288851
PLA2G4A	P47712	445	526	1	749	Chain	ID=PRO_0000187262;Note=Cytosolic phospholipase A2
PLA2G4A	P47712	445	526	140	740	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4A	P47712	445	526	505	505	Modified residue	Note=Phosphoserine%3B by MAPK;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8381049,ECO:0000269|PubMed:9468497;Dbxref=PMID:8381049,PMID:9468497
PLA2G4A	P47712	445	526	515	515	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P50393
PLA2G4A	P47712	445	526	485	485	Natural variant	ID=VAR_070779;Note=Probable disease-associated mutation found in a compound heterozygote affected by phospholipase A2 deficiency also carrying P-111. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18451993;Dbxref=dbSNP:rs121434635,PMID:18451993
PLA2G4A	P47712	445	526	505	505	Mutagenesis	Note=Decreases agonist-stimulated release of arachidonic acid. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8381049;Dbxref=PMID:8381049
PLA2G4A	P47712	445	526	463	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CJY
PLA2G4A	P47712	445	526	488	490	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CJY
PLA2G4A	P47712	445	526	492	495	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CJY
PLA2G4C	Q9UP65	335	367	1	538	Chain	ID=PRO_0000022995;Note=Cytosolic phospholipase A2 gamma
PLA2G4C	Q9UP65	299	335	1	538	Chain	ID=PRO_0000022995;Note=Cytosolic phospholipase A2 gamma
PLA2G4C	Q9UP65	281	299	1	538	Chain	ID=PRO_0000022995;Note=Cytosolic phospholipase A2 gamma
PLA2G4C	Q9UP65	263	281	1	538	Chain	ID=PRO_0000022995;Note=Cytosolic phospholipase A2 gamma
PLA2G4C	Q9UP65	236	254	1	538	Chain	ID=PRO_0000022995;Note=Cytosolic phospholipase A2 gamma
PLA2G4C	Q9UP65	189	236	1	538	Chain	ID=PRO_0000022995;Note=Cytosolic phospholipase A2 gamma
PLA2G4C	Q9UP65	335	367	1	541	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4C	Q9UP65	299	335	1	541	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4C	Q9UP65	281	299	1	541	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4C	Q9UP65	263	281	1	541	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4C	Q9UP65	236	254	1	541	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4C	Q9UP65	189	236	1	541	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4C	Q9UP65	335	367	337	337	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PLA2G4C	Q9UP65	189	236	203	203	Natural variant	ID=VAR_018422;Note=S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10085124,ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3,ECO:0000269|Ref.5;Dbxref=dbSNP:rs156631,PMID:10085124,PMID:14702039
PLA2G4C	Q9UP65	189	236	226	226	Natural variant	ID=VAR_018766;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs11564541
PLA2G4C	Q9UP65	335	367	360	360	Natural variant	ID=VAR_018767;Note=T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs11564620
PLA2G4F	Q68DD2	513	559	1	849	Chain	ID=PRO_0000247027;Note=Cytosolic phospholipase A2 zeta
PLA2G4F	Q68DD2	513	559	306	849	Domain	Note=PLA2c;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00555
PLA2G4F	Q68DD2	513	559	455	849	Alternative sequence	ID=VSP_019889;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PABPC4	Q13310	468	497	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	324	415	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	292	324	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	246	292	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC4	Q13310	324	415	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC4	Q13310	292	324	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC4	Q13310	292	324	304	304	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PABPC4	Q13310	292	324	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
PABPC4	Q13310	292	324	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PABPC4	Q13310	324	415	361	361	Modified residue	Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6
PABPC4	Q13310	324	415	364	364	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PABPC4	Q13310	324	415	361	361	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PABPC4	Q13310	324	415	375	375	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PABPC4	Q13310	468	497	468	468	Alternative sequence	ID=VSP_043357;Note=In isoform 3. T->TGNAPASRGLPTTTQRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PABPC4	Q13310	468	497	470	497	Alternative sequence	ID=VSP_013335;Note=In isoform 2. SECPDRLAMDFGGAGAAQQGLTDSCQSG->NAPASRGLPTTTQRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PABPC4	Q13310	324	415	382	382	Natural variant	ID=VAR_054048;Note=Y->F;Dbxref=dbSNP:rs9820
PABPC1	P11940	445	482	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
PABPC1	P11940	324	415	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
PABPC1	P11940	246	292	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
PABPC1	P11940	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC1	P11940	324	415	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC1	P11940	246	292	166	289	Region	Note=CSDE1-binding
PABPC1	P11940	324	415	385	385	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PABPC1	P11940	445	482	455	455	Modified residue	Note=Omega-N-methylated arginine%3B by CARM1%3B partial;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	445	482	460	460	Modified residue	Note=Omega-N-methylated arginine%3B by CARM1%3B partial;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	445	482	475	475	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29341
PABPC1	P11940	445	482	481	481	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PABPC1	P11940	445	482	447	535	Alternative sequence	ID=VSP_009846;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
PABPC1	P11940	445	482	455	455	Mutagenesis	Note=Greatly reduces methylation by CARM1 (in vitro)%3B when associated with A-460. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	445	482	460	460	Mutagenesis	Note=Greatly reduces methylation by CARM1 (in vitro)%3B when associated with A-455. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	324	415	410	410	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PACRG	Q96M98	204	243	1	296	Chain	ID=PRO_0000058169;Note=Parkin coregulated gene protein
PACRG	Q96M98	204	243	205	243	Alternative sequence	ID=VSP_010033;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12547187,ECO:0000303|PubMed:15489334;Dbxref=PMID:12547187,PMID:15489334
PACRGL	Q8N7B6	122	167	1	248	Chain	ID=PRO_0000278243;Note=PACRG-like protein
PACRGL	Q8N7B6	203	230	1	248	Chain	ID=PRO_0000278243;Note=PACRG-like protein
PACRGL	Q8N7B6	122	167	70	167	Alternative sequence	ID=VSP_043351;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PACRGL	Q8N7B6	122	167	70	122	Alternative sequence	ID=VSP_045095;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PACRGL	Q8N7B6	203	230	203	229	Alternative sequence	ID=VSP_023206;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PACRGL	Q8N7B6	203	230	204	248	Alternative sequence	ID=VSP_045096;Note=In isoform 4. LSKRLMDKKFKEPITSALQKLEQHGGSGSLSIIKSKIPTYCSICC->DPVQLMRFPRPLLGLMICQKDPWNSGKLLLAVMVSYNTQKIKIKISKGEP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADCYAP1R1	P41586	95	109	21	468	Chain	ID=PRO_0000012841;Note=Pituitary adenylate cyclase-activating polypeptide type I receptor
ADCYAP1R1	P41586	392	406	21	468	Chain	ID=PRO_0000012841;Note=Pituitary adenylate cyclase-activating polypeptide type I receptor
ADCYAP1R1	P41586	95	109	21	155	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCYAP1R1	P41586	392	406	386	405	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCYAP1R1	P41586	392	406	406	468	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCYAP1R1	P41586	95	109	54	118	Disulfide bond	.
ADCYAP1R1	P41586	95	109	77	134	Disulfide bond	.
ADCYAP1R1	P41586	95	109	89	109	Alternative sequence	ID=VSP_042670;Note=In isoform S%2C isoform S-HOP1 and isoform VS. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRADC1	Q9BSG0	93	148	22	188	Chain	ID=PRO_0000022001;Note=Protease-associated domain-containing protein 1
PRADC1	Q9BSG0	93	148	83	163	Domain	Note=PA
PRADC1	Q9BSG0	93	148	121	121	Site	Note=Not glycosylated;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRADC1	Q9BSG0	93	148	121	121	Mutagenesis	Note=Does not affect glycosylation state. Abolishes N-glycosylation%3B when associated with Q-171. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15498570;Dbxref=PMID:15498570
PAIP1	Q9H074	282	324	1	479	Chain	ID=PRO_0000058177;Note=Polyadenylate-binding protein-interacting protein 1
PAIP1	Q9H074	145	207	1	479	Chain	ID=PRO_0000058177;Note=Polyadenylate-binding protein-interacting protein 1
PAIP1	Q9H074	282	324	159	376	Domain	Note=MIF4G
PAIP1	Q9H074	145	207	159	376	Domain	Note=MIF4G
PAIP1	Q9H074	145	207	158	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	145	207	173	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	145	207	176	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	145	207	194	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	282	324	288	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	282	324	294	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	282	324	313	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAK4	O96013	68	221	1	591	Chain	ID=PRO_0000086474;Note=Serine/threonine-protein kinase PAK 4
PAK4	O96013	68	221	1	591	Chain	ID=PRO_0000086474;Note=Serine/threonine-protein kinase PAK 4
PAK4	O96013	68	221	1	591	Chain	ID=PRO_0000086474;Note=Serine/threonine-protein kinase PAK 4
PAK4	O96013	68	221	25	320	Region	Note=Linker
PAK4	O96013	68	221	25	320	Region	Note=Linker
PAK4	O96013	68	221	25	320	Region	Note=Linker
PAK4	O96013	68	221	105	108	Compositional bias	Note=Poly-Pro
PAK4	O96013	68	221	105	108	Compositional bias	Note=Poly-Pro
PAK4	O96013	68	221	105	108	Compositional bias	Note=Poly-Pro
PAK4	O96013	68	221	78	78	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PAK4	O96013	68	221	78	78	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PAK4	O96013	68	221	78	78	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PAK4	O96013	68	221	104	104	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	104	104	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	104	104	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PAK4	O96013	68	221	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
PAK4	O96013	68	221	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
PAK4	O96013	68	221	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569
PAK4	O96013	68	221	187	187	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PAK4	O96013	68	221	187	187	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PAK4	O96013	68	221	187	187	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PAK4	O96013	68	221	195	195	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PAK4	O96013	68	221	195	195	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PAK4	O96013	68	221	195	195	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PAK4	O96013	68	221	207	207	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PAK4	O96013	68	221	207	207	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PAK4	O96013	68	221	207	207	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PAK4	O96013	68	221	69	221	Alternative sequence	ID=VSP_017572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10574461,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:10574461,PMID:14702039,PMID:17974005
PAK4	O96013	68	221	69	221	Alternative sequence	ID=VSP_017572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10574461,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:10574461,PMID:14702039,PMID:17974005
PAK4	O96013	68	221	69	221	Alternative sequence	ID=VSP_017572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10574461,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:10574461,PMID:14702039,PMID:17974005
PAK4	O96013	68	221	120	120	Alternative sequence	ID=VSP_004892;Note=In isoform 2. E->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	120	120	Alternative sequence	ID=VSP_004892;Note=In isoform 2. E->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	120	120	Alternative sequence	ID=VSP_004892;Note=In isoform 2. E->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	121	285	Alternative sequence	ID=VSP_004893;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	121	285	Alternative sequence	ID=VSP_004893;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	121	285	Alternative sequence	ID=VSP_004893;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	132	221	Alternative sequence	ID=VSP_017573;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	132	221	Alternative sequence	ID=VSP_017573;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	132	221	Alternative sequence	ID=VSP_017573;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PAK4	O96013	68	221	135	135	Natural variant	ID=VAR_040970;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56099436,PMID:17344846
PAK4	O96013	68	221	135	135	Natural variant	ID=VAR_040970;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56099436,PMID:17344846
PAK4	O96013	68	221	135	135	Natural variant	ID=VAR_040970;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56099436,PMID:17344846
PAK4	O96013	68	221	139	139	Natural variant	ID=VAR_040971;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35655056,PMID:17344846
PAK4	O96013	68	221	139	139	Natural variant	ID=VAR_040971;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35655056,PMID:17344846
PAK4	O96013	68	221	139	139	Natural variant	ID=VAR_040971;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35655056,PMID:17344846
PALB2	Q86YC2	999	1037	1	1186	Chain	ID=PRO_0000252391;Note=Partner and localizer of BRCA2
PALB2	Q86YC2	945	998	1	1186	Chain	ID=PRO_0000252391;Note=Partner and localizer of BRCA2
PALB2	Q86YC2	862	916	1	1186	Chain	ID=PRO_0000252391;Note=Partner and localizer of BRCA2
PALB2	Q86YC2	838	862	1	1186	Chain	ID=PRO_0000252391;Note=Partner and localizer of BRCA2
PALB2	Q86YC2	862	916	854	915	Repeat	Note=WD 1
PALB2	Q86YC2	838	862	854	915	Repeat	Note=WD 1
PALB2	Q86YC2	945	998	917	961	Repeat	Note=WD 2
PALB2	Q86YC2	999	1037	962	1009	Repeat	Note=WD 3
PALB2	Q86YC2	945	998	962	1009	Repeat	Note=WD 3
PALB2	Q86YC2	999	1037	1010	1052	Repeat	Note=WD 4
PALB2	Q86YC2	999	1037	775	1186	Region	Note=Required for interaction with POLH and POLH DNA synthesis stimulation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	945	998	775	1186	Region	Note=Required for interaction with POLH and POLH DNA synthesis stimulation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	862	916	775	1186	Region	Note=Required for interaction with POLH and POLH DNA synthesis stimulation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	838	862	775	1186	Region	Note=Required for interaction with POLH and POLH DNA synthesis stimulation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	999	1037	853	1186	Region	Note=Interaction with RAD51%2C BRCA2 and POLH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	945	998	853	1186	Region	Note=Interaction with RAD51%2C BRCA2 and POLH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	862	916	853	1186	Region	Note=Interaction with RAD51%2C BRCA2 and POLH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	838	862	853	1186	Region	Note=Interaction with RAD51%2C BRCA2 and POLH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656
PALB2	Q86YC2	862	916	864	864	Natural variant	ID=VAR_054150;Note=P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18987736,ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45568339,PMID:18987736,PMID:21618343
PALB2	Q86YC2	945	998	966	966	Natural variant	ID=VAR_066376;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs786204248,PMID:21618343
PALB2	Q86YC2	945	998	998	998	Natural variant	ID=VAR_066377;Note=May be associated with breast cancer susceptibility. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45551636,PMID:21618343
PALB2	Q86YC2	999	1037	1025	1025	Natural variant	ID=VAR_066378;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs746872839,PMID:21618343
PALB2	Q86YC2	999	1037	1030	1030	Mutagenesis	Note=Unstable and promotes protein degradation%3B reduces interaction with RAD51C and RAD51. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24141787;Dbxref=PMID:24141787
PALB2	Q86YC2	838	862	855	861	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	862	916	869	877	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	862	916	884	913	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	945	998	938	947	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	945	998	958	972	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	945	998	973	975	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	945	998	976	984	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	945	998	988	994	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	999	1037	1000	1006	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	999	1037	1013	1020	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	999	1037	1025	1030	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PALB2	Q86YC2	999	1037	1033	1039	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W18
PAWR	Q96IZ0	277	312	1	340	Chain	ID=PRO_0000058236;Note=PRKC apoptosis WT1 regulator protein
PAWR	Q96IZ0	172	216	1	340	Chain	ID=PRO_0000058236;Note=PRKC apoptosis WT1 regulator protein
PAWR	Q96IZ0	172	216	145	203	Region	Note=Selective for apoptosis induction in cancer cells (SAC)
PAWR	Q96IZ0	277	312	300	340	Region	Note=Leucine-zipper
PAWR	Q96IZ0	172	216	186	206	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PAWR	Q96IZ0	172	216	202	202	Natural variant	ID=VAR_022468;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs8176870
PAWR	Q96IZ0	172	216	199	199	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAWR	Q96IZ0	277	312	281	281	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PBLD	P30039	230	251	1	288	Chain	ID=PRO_0000162383;Note=Phenazine biosynthesis-like domain-containing protein
PBLD	P30039	131	141	1	288	Chain	ID=PRO_0000162383;Note=Phenazine biosynthesis-like domain-containing protein
PBLD	P30039	61	94	1	288	Chain	ID=PRO_0000162383;Note=Phenazine biosynthesis-like domain-containing protein
PBLD	P30039	230	251	1	288	Chain	ID=PRO_0000162383;Note=Phenazine biosynthesis-like domain-containing protein
PBLD	P30039	131	141	1	288	Chain	ID=PRO_0000162383;Note=Phenazine biosynthesis-like domain-containing protein
PBLD	P30039	61	94	1	288	Chain	ID=PRO_0000162383;Note=Phenazine biosynthesis-like domain-containing protein
PBLD	P30039	61	94	62	62	Natural variant	ID=VAR_072403;Note=S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22068589;Dbxref=dbSNP:rs756247151,PMID:22068589
PBLD	P30039	61	94	62	62	Natural variant	ID=VAR_072403;Note=S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22068589;Dbxref=dbSNP:rs756247151,PMID:22068589
PCGF5	Q86SE9	88	108	1	256	Chain	ID=PRO_0000277868;Note=Polycomb group RING finger protein 5
PCGF5	Q86SE9	221	241	1	256	Chain	ID=PRO_0000277868;Note=Polycomb group RING finger protein 5
PCGF5	Q86SE9	88	108	1	256	Chain	ID=PRO_0000277868;Note=Polycomb group RING finger protein 5
PCGF5	Q86SE9	221	241	1	256	Chain	ID=PRO_0000277868;Note=Polycomb group RING finger protein 5
PCGF5	Q86SE9	88	108	50	256	Alternative sequence	ID=VSP_023119;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCGF5	Q86SE9	221	241	50	256	Alternative sequence	ID=VSP_023119;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCGF5	Q86SE9	88	108	50	256	Alternative sequence	ID=VSP_023119;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCGF5	Q86SE9	221	241	50	256	Alternative sequence	ID=VSP_023119;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCGF5	Q86SE9	88	108	86	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4S3O
PCGF5	Q86SE9	88	108	86	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4S3O
PAX8	Q06710	336	370	1	450	Chain	ID=PRO_0000050197;Note=Paired box protein Pax-8
PAX8	Q06710	64	129	1	450	Chain	ID=PRO_0000050197;Note=Paired box protein Pax-8
PAX8	Q06710	396	425	1	450	Chain	ID=PRO_0000050197;Note=Paired box protein Pax-8
PAX8	Q06710	362	396	1	450	Chain	ID=PRO_0000050197;Note=Paired box protein Pax-8
PAX8	Q06710	299	362	1	450	Chain	ID=PRO_0000050197;Note=Paired box protein Pax-8
PAX8	Q06710	64	129	1	450	Chain	ID=PRO_0000050197;Note=Paired box protein Pax-8
PAX8	Q06710	64	129	9	135	Domain	Note=Paired;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00381
PAX8	Q06710	64	129	9	135	Domain	Note=Paired;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00381
PAX8	Q06710	299	362	315	327	Compositional bias	Note=Ser-rich
PAX8	Q06710	299	362	303	303	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00288
PAX8	Q06710	336	370	260	450	Alternative sequence	ID=VSP_002374;Note=In isoform 4. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->GERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	396	425	260	450	Alternative sequence	ID=VSP_002374;Note=In isoform 4. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->GERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	362	396	260	450	Alternative sequence	ID=VSP_002374;Note=In isoform 4. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->GERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	299	362	260	450	Alternative sequence	ID=VSP_002374;Note=In isoform 4. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->GERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	336	370	260	450	Alternative sequence	ID=VSP_002375;Note=In isoform 5. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->EVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	396	425	260	450	Alternative sequence	ID=VSP_002375;Note=In isoform 5. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->EVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	362	396	260	450	Alternative sequence	ID=VSP_002375;Note=In isoform 5. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->EVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	299	362	260	450	Alternative sequence	ID=VSP_002375;Note=In isoform 5. GLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->EVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	336	370	300	450	Alternative sequence	ID=VSP_002373;Note=In isoform 3. DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->APPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	396	425	300	450	Alternative sequence	ID=VSP_002373;Note=In isoform 3. DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->APPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	362	396	300	450	Alternative sequence	ID=VSP_002373;Note=In isoform 3. DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->APPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	299	362	300	450	Alternative sequence	ID=VSP_002373;Note=In isoform 3. DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL->APPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7737192;Dbxref=PMID:7737192
PAX8	Q06710	336	370	300	362	Alternative sequence	ID=VSP_002372;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1337742;Dbxref=PMID:1337742
PAX8	Q06710	362	396	300	362	Alternative sequence	ID=VSP_002372;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1337742;Dbxref=PMID:1337742
PAX8	Q06710	299	362	300	362	Alternative sequence	ID=VSP_002372;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1337742;Dbxref=PMID:1337742
PAX8	Q06710	299	362	329	329	Natural variant	ID=VAR_012773;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1337742;Dbxref=dbSNP:rs3188996,PMID:1337742
PAX8	Q06710	299	362	305	305	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAX8	Q06710	299	362	322	322	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAX8	Q06710	396	425	418	418	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAX8	Q06710	64	129	88	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	88	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	104	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	104	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	119	121	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	119	121	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	125	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PAX8	Q06710	64	129	125	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K27
PCNT	O95613	1055	1104	1	3336	Chain	ID=PRO_0000058257;Note=Pericentrin
PCNT	O95613	1597	1654	1	3336	Chain	ID=PRO_0000058257;Note=Pericentrin
PCNT	O95613	1705	1998	1	3336	Chain	ID=PRO_0000058257;Note=Pericentrin
PCNT	O95613	2393	2440	1	3336	Chain	ID=PRO_0000058257;Note=Pericentrin
PCNT	O95613	1055	1104	1010	1146	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PCNT	O95613	1597	1654	1299	1949	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PCNT	O95613	1705	1998	1299	1949	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PCNT	O95613	1597	1654	1653	1653	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PCNT	O95613	1705	1998	1712	1712	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48725
PCNT	O95613	1597	1654	1639	1639	Natural variant	ID=VAR_043884;Note=I->V;Dbxref=dbSNP:rs6518291
PCNT	O95613	1705	1998	1841	1841	Natural variant	ID=VAR_043885;Note=N->S;Dbxref=dbSNP:rs35940413
PCNT	O95613	1705	1998	1953	1953	Natural variant	ID=VAR_043886;Note=R->H;Dbxref=dbSNP:rs34268261
PCNT	O95613	1705	1998	1960	1960	Natural variant	ID=VAR_043887;Note=R->Q;Dbxref=dbSNP:rs34813667
PCNT	O95613	2393	2440	2424	2424	Natural variant	ID=VAR_069421;Note=Found in a patient with mental retardation%2C no speech%2C facial and limbs dysmorphisms. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs371893416,PMID:23033978
PCSK5	Q92824	99	137	33	114	Propeptide	ID=PRO_0000027102;Ontology_term=ECO:0000250;evidence=ECO:0000250
PCSK5	Q92824	99	137	115	1860	Chain	ID=PRO_0000027103;Note=Proprotein convertase subtilisin/kexin type 5
PCSK5	Q92824	298	369	115	1860	Chain	ID=PRO_0000027103;Note=Proprotein convertase subtilisin/kexin type 5
PCSK5	Q92824	99	137	115	1743	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCSK5	Q92824	298	369	115	1743	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCSK5	Q92824	298	369	166	453	Domain	Note=Peptidase S8
PCSK5	Q92824	99	137	114	115	Site	Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250
PCSK5	Q92824	99	137	118	118	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCSK5	Q92824	99	137	121	121	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCYOX1L	Q8NBM8	227	274	23	494	Chain	ID=PRO_0000280286;Note=Prenylcysteine oxidase-like
PCYOX1L	Q8NBM8	227	274	83	494	Alternative sequence	ID=VSP_039272;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
CD274	Q9NZQ7	17	131	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD274	Q9NZQ7	17	131	19	290	Chain	ID=PRO_0000014553;Note=Programmed cell death 1 ligand 1
CD274	Q9NZQ7	263	283	19	290	Chain	ID=PRO_0000014553;Note=Programmed cell death 1 ligand 1
CD274	Q9NZQ7	17	131	19	238	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD274	Q9NZQ7	263	283	260	290	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD274	Q9NZQ7	17	131	19	127	Domain	Note=Ig-like V-type
CD274	Q9NZQ7	17	131	35	35	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD274	Q9NZQ7	17	131	40	114	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:18287011;Dbxref=PMID:18287011
CD274	Q9NZQ7	17	131	19	132	Alternative sequence	ID=VSP_013735;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15780196,ECO:0000303|Ref.4;Dbxref=PMID:15780196
CD274	Q9NZQ7	263	283	179	290	Alternative sequence	ID=VSP_013737;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15780196;Dbxref=PMID:14702039,PMID:15780196
CD274	Q9NZQ7	17	131	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	36	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5C3T
CD274	Q9NZQ7	17	131	50	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	54	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	62	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	74	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	82	84	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	89	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
CD274	Q9NZQ7	17	131	110	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O45
PDCD1LG2	Q9BQ51	120	210	20	273	Chain	ID=PRO_0000014555;Note=Programmed cell death 1 ligand 2
PDCD1LG2	Q9BQ51	210	255	20	273	Chain	ID=PRO_0000014555;Note=Programmed cell death 1 ligand 2
PDCD1LG2	Q9BQ51	120	210	20	220	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	210	255	20	220	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	210	255	221	241	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	210	255	242	273	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	120	210	122	203	Domain	Note=Ig-like C2-type
PDCD1LG2	Q9BQ51	120	210	157	157	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	120	210	163	163	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	120	210	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDCD1LG2	Q9BQ51	120	210	143	192	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PDCD1LG2	Q9BQ51	120	210	121	211	Alternative sequence	ID=VSP_013740;Note=In isoform 2. ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQS->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15253154;Dbxref=PMID:15253154
PDCD1LG2	Q9BQ51	210	255	121	211	Alternative sequence	ID=VSP_013740;Note=In isoform 2. ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQS->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15253154;Dbxref=PMID:15253154
PDCD1LG2	Q9BQ51	120	210	121	182	Alternative sequence	ID=VSP_013738;Note=In isoform 3. ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRL->DGTQDPSNLAASHFHPLLHHCFHFHSHSDSPKKTTLSKAVFFKRHNKKTCHHNKEGSEQCYL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15253154;Dbxref=PMID:15253154
PDCD1LG2	Q9BQ51	120	210	183	273	Alternative sequence	ID=VSP_013739;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15253154;Dbxref=PMID:15253154
PDCD1LG2	Q9BQ51	210	255	183	273	Alternative sequence	ID=VSP_013739;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15253154;Dbxref=PMID:15253154
PDCD1LG2	Q9BQ51	210	255	229	229	Natural variant	ID=VAR_022449;Note=F->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11224527,ECO:0000269|PubMed:11283156,ECO:0000269|PubMed:15253154,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs7854303,PMID:11224527,PMID:11283156,PMID:15253154,PMID:15489334
PDCD1LG2	Q9BQ51	210	255	241	241	Natural variant	ID=VAR_049843;Note=I->T;Dbxref=dbSNP:rs7854413
PDCD5	O14737	86	110	2	125	Chain	ID=PRO_0000121545;Note=Programmed cell death protein 5
PDCD5	O14737	86	110	89	125	Alternative sequence	ID=VSP_056203;Note=In isoform 2. EQGLIEILKKVSQQTEKTTTVKFNRRKVMDSDEDDDY->LDSLEELYCYLLYQNMASKGQLHLHWITEFLLTLRRNCWRE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PDCD5	O14737	86	110	104	104	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDCD5	O14737	86	110	89	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRU
PDCD5	O14737	86	110	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K6B
RNF144B	Q7Z419	55	90	1	303	Chain	ID=PRO_0000055911;Note=E3 ubiquitin-protein ligase RNF144B
RNF144B	Q7Z419	55	90	30	80	Zinc finger	Note=RING-type 1%3B atypical
RNF144B	Q7Z419	55	90	22	110	Alternative sequence	ID=VSP_055854;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OSTF1	Q92882	27	44	2	214	Chain	ID=PRO_0000067035;Note=Osteoclast-stimulating factor 1
OSTF1	Q92882	83	119	2	214	Chain	ID=PRO_0000067035;Note=Osteoclast-stimulating factor 1
OSTF1	Q92882	162	195	2	214	Chain	ID=PRO_0000067035;Note=Osteoclast-stimulating factor 1
OSTF1	Q92882	27	44	12	71	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
OSTF1	Q92882	83	119	72	101	Repeat	Note=ANK 1
OSTF1	Q92882	83	119	105	135	Repeat	Note=ANK 2
OSTF1	Q92882	162	195	139	168	Repeat	Note=ANK 3
OSTF1	Q92882	27	44	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZLM
OSTF1	Q92882	83	119	76	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
OSTF1	Q92882	83	119	86	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
OSTF1	Q92882	83	119	109	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
OSTF1	Q92882	83	119	119	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
OSTF1	Q92882	162	195	153	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
OSTF1	Q92882	162	195	176	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
OSTF1	Q92882	162	195	183	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHR
DDOST	P39656	105	134	43	456	Chain	ID=PRO_0000021957;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
DDOST	P39656	68	105	43	456	Chain	ID=PRO_0000021957;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
DDOST	P39656	105	134	43	427	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DDOST	P39656	68	105	43	427	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DDOST	P39656	105	134	69	105	Alternative sequence	ID=VSP_055498;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDOST	P39656	68	105	69	105	Alternative sequence	ID=VSP_055498;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDOST	P39656	105	134	124	141	Alternative sequence	ID=VSP_055499;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TP53I13	Q8NBR0	24	47	1	27	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I13	Q8NBR0	24	47	28	393	Chain	ID=PRO_0000333824;Note=Tumor protein p53-inducible protein 13
TP53I13	Q8NBR0	47	61	28	393	Chain	ID=PRO_0000333824;Note=Tumor protein p53-inducible protein 13
TP53I13	Q8NBR0	61	104	28	393	Chain	ID=PRO_0000333824;Note=Tumor protein p53-inducible protein 13
TP53I13	Q8NBR0	24	47	28	309	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I13	Q8NBR0	47	61	28	309	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TP53I13	Q8NBR0	61	104	28	309	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARP4	Q9UKK3	1222	1582	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	1149	1181	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	808	854	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	682	711	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	405	450	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	293	351	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	197	247	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	159	197	1	1724	Chain	ID=PRO_0000211330;Note=Poly [ADP-ribose] polymerase 4
PARP4	Q9UKK3	293	351	242	370	Domain	Note=PARP alpha-helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00398
PARP4	Q9UKK3	197	247	242	370	Domain	Note=PARP alpha-helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00398
PARP4	Q9UKK3	405	450	369	573	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP4	Q9UKK3	682	711	607	735	Domain	Note=VIT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00801
PARP4	Q9UKK3	1222	1582	1562	1724	Region	Note=Interaction with the major vault protein
PARP4	Q9UKK3	1222	1582	1237	1249	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PARP4	Q9UKK3	293	351	333	333	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PARP4	Q9UKK3	1222	1582	1236	1236	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
PARP4	Q9UKK3	1222	1582	1335	1335	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
PARP4	Q9UKK3	1222	1582	1476	1476	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PARP4	Q9UKK3	1222	1582	1504	1504	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PARP4	Q9UKK3	197	247	215	215	Natural variant	ID=VAR_056647;Note=F->Y;Dbxref=dbSNP:rs9318600
PARP4	Q9UKK3	1222	1582	1253	1253	Natural variant	ID=VAR_056653;Note=S->T;Dbxref=dbSNP:rs4986822
PARP4	Q9UKK3	1222	1582	1265	1265	Natural variant	ID=VAR_016090;Note=G->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10644454,ECO:0000269|PubMed:8724849;Dbxref=dbSNP:rs1050110,PMID:10644454,PMID:8724849
PARP4	Q9UKK3	1222	1582	1280	1280	Natural variant	ID=VAR_016091;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10644454,ECO:0000269|PubMed:8724849;Dbxref=dbSNP:rs13428,PMID:10644454,PMID:8724849
PARP4	Q9UKK3	1222	1582	1328	1328	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1328	1328	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1328	1328	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1331	1331	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1331	1331	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1331	1331	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1394	1394	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1394	1394	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1394	1394	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1459	1459	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1459	1459	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1459	1459	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1550	1550	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1550	1550	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1550	1550	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1555	1555	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1564	1564	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1564	1564	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PARP4	Q9UKK3	1222	1582	1564	1564	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
MMD	Q15546	115	148	1	238	Chain	ID=PRO_0000218854;Note=Monocyte to macrophage differentiation factor
MMD	Q15546	90	114	1	238	Chain	ID=PRO_0000218854;Note=Monocyte to macrophage differentiation factor
MMD	Q15546	90	114	83	101	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMD	Q15546	115	148	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMD	Q15546	90	114	102	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMD	Q15546	115	148	123	124	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMD	Q15546	115	148	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMD	Q15546	115	148	146	151	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMD	Q15546	90	114	92	92	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PATL1	Q86TB9	241	271	1	770	Chain	ID=PRO_0000320963;Note=Protein PAT1 homolog 1
PATL1	Q86TB9	142	207	1	770	Chain	ID=PRO_0000320963;Note=Protein PAT1 homolog 1
PATL1	Q86TB9	241	271	1	397	Region	Note=Involved in nuclear foci localization
PATL1	Q86TB9	142	207	1	397	Region	Note=Involved in nuclear foci localization
PATL1	Q86TB9	241	271	85	388	Region	Note=Region N%3B interaction with decapping machinery
PATL1	Q86TB9	142	207	85	388	Region	Note=Region N%3B interaction with decapping machinery
PATL1	Q86TB9	241	271	223	397	Region	Note=Involved in RNA-binding
PATL1	Q86TB9	241	271	155	338	Compositional bias	Note=Pro-rich
PATL1	Q86TB9	142	207	155	338	Compositional bias	Note=Pro-rich
PATL1	Q86TB9	142	207	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PATL1	Q86TB9	142	207	178	178	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TC46
PATL1	Q86TB9	142	207	179	179	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:21406692,PMID:23186163
PATL1	Q86TB9	142	207	184	184	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:21406692,PMID:23186163
PATL1	Q86TB9	142	207	194	194	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PATL1	Q86TB9	241	271	263	263	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PATL1	Q86TB9	241	271	1	659	Alternative sequence	ID=VSP_031777;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PATL1	Q86TB9	142	207	1	659	Alternative sequence	ID=VSP_031777;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PATL1	Q86TB9	142	207	1	143	Alternative sequence	ID=VSP_031778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PATL1	Q86TB9	241	271	242	271	Alternative sequence	ID=VSP_040576;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PATL1	Q86TB9	142	207	160	160	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASD1	Q8IV76	39	69	1	773	Chain	ID=PRO_0000299445;Note=Circadian clock protein PASD1
PASD1	Q8IV76	39	69	30	102	Domain	Note=PAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
PASD1	Q8IV76	39	69	45	45	Mutagenesis	Note=Reduces inhibition of CLOCK-ARNTL/BMAL1 heterodimer activity%3B when associated with E-36. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25936801;Dbxref=PMID:25936801
PCCB	P05166	101	124	29	539	Chain	ID=PRO_0000000293;Note=Propionyl-CoA carboxylase beta chain%2C mitochondrial
PCCB	P05166	124	143	29	539	Chain	ID=PRO_0000000293;Note=Propionyl-CoA carboxylase beta chain%2C mitochondrial
PCCB	P05166	181	218	29	539	Chain	ID=PRO_0000000293;Note=Propionyl-CoA carboxylase beta chain%2C mitochondrial
PCCB	P05166	363	399	29	539	Chain	ID=PRO_0000000293;Note=Propionyl-CoA carboxylase beta chain%2C mitochondrial
PCCB	P05166	101	124	32	290	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
PCCB	P05166	124	143	32	290	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
PCCB	P05166	181	218	32	290	Domain	Note=CoA carboxyltransferase N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01136
PCCB	P05166	363	399	294	533	Domain	Note=CoA carboxyltransferase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01137
PCCB	P05166	101	124	32	533	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
PCCB	P05166	124	143	32	533	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
PCCB	P05166	181	218	32	533	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
PCCB	P05166	363	399	32	533	Region	Note=Carboxyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01138
PCCB	P05166	101	124	124	124	Alternative sequence	ID=VSP_042568;Note=In isoform 2. Q->QQIIGWAQWLPLVISALWEAE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCCB	P05166	124	143	124	124	Alternative sequence	ID=VSP_042568;Note=In isoform 2. Q->QQIIGWAQWLPLVISALWEAE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PCCB	P05166	101	124	106	106	Natural variant	ID=VAR_000272;Note=In PA-2. S->R
PCCB	P05166	101	124	107	107	Natural variant	ID=VAR_023848;Note=In PA-2. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559849;Dbxref=PMID:12559849
PCCB	P05166	101	124	112	112	Natural variant	ID=VAR_023849;Note=In PA-2. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559849;Dbxref=dbSNP:rs202247818,PMID:12559849
PCCB	P05166	124	143	131	131	Natural variant	ID=VAR_000273;Note=In PA-2. G->R
PCCB	P05166	124	143	140	140	Natural variant	ID=VAR_009081;Note=In PA-2. K->KICK
PCCB	P05166	181	218	188	188	Natural variant	ID=VAR_023852;Note=In PA-2. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559849;Dbxref=dbSNP:rs746102997,PMID:12559849
PCCB	P05166	181	218	198	198	Natural variant	ID=VAR_000276;Note=In PA-2. G->D;Dbxref=dbSNP:rs762354873
PCCB	P05166	181	218	205	205	Natural variant	ID=VAR_009082;Note=In PA-2. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10447268;Dbxref=PMID:10447268
LPCAT2	Q7L5N7	312	353	1	544	Chain	ID=PRO_0000247058;Note=Lysophosphatidylcholine acyltransferase 2
LPCAT2	Q7L5N7	312	353	79	544	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDS5A	Q29RF7	1113	1134	1	1337	Chain	ID=PRO_0000296341;Note=Sister chromatid cohesion protein PDS5 homolog A
PDS5A	Q29RF7	1073	1113	1	1337	Chain	ID=PRO_0000296341;Note=Sister chromatid cohesion protein PDS5 homolog A
PDS5A	Q29RF7	812	835	1	1337	Chain	ID=PRO_0000296341;Note=Sister chromatid cohesion protein PDS5 homolog A
PDS5A	Q29RF7	759	812	1	1337	Chain	ID=PRO_0000296341;Note=Sister chromatid cohesion protein PDS5 homolog A
PDS5A	Q29RF7	462	499	1	1337	Chain	ID=PRO_0000296341;Note=Sister chromatid cohesion protein PDS5 homolog A
PDS5A	Q29RF7	114	143	1	1337	Chain	ID=PRO_0000296341;Note=Sister chromatid cohesion protein PDS5 homolog A
PDS5A	Q29RF7	1073	1113	1097	1097	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PDS5A	Q29RF7	1113	1134	601	1337	Alternative sequence	ID=VSP_052492;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PDS5A	Q29RF7	1073	1113	601	1337	Alternative sequence	ID=VSP_052492;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PDS5A	Q29RF7	812	835	601	1337	Alternative sequence	ID=VSP_052492;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PDS5A	Q29RF7	759	812	601	1337	Alternative sequence	ID=VSP_052492;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PDS5A	Q29RF7	462	499	471	471	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RNF144A	P50876	219	249	1	292	Chain	ID=PRO_0000056298;Note=E3 ubiquitin-protein ligase RNF144A
PARP10	Q53GL7	592	807	1	1025	Chain	ID=PRO_0000252435;Note=Poly [ADP-ribose] polymerase 10
PARP10	Q53GL7	145	224	1	1025	Chain	ID=PRO_0000252435;Note=Poly [ADP-ribose] polymerase 10
PARP10	Q53GL7	60	145	1	1025	Chain	ID=PRO_0000252435;Note=Poly [ADP-ribose] polymerase 10
PARP10	Q53GL7	592	807	806	1025	Domain	Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397
PARP10	Q53GL7	592	807	700	907	Region	Note=Myc binding
PARP10	Q53GL7	592	807	650	667	Motif	Note=Ubiquitin-interacting
PARP10	Q53GL7	592	807	673	690	Motif	Note=Ubiquitin-interacting
PARP10	Q53GL7	145	224	186	193	Compositional bias	Note=Poly-Leu
PARP10	Q53GL7	592	807	588	697	Compositional bias	Note=Glu-rich
PARP10	Q53GL7	60	145	101	101	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16455663;Dbxref=PMID:16455663
PARP10	Q53GL7	592	807	663	663	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
PARP10	Q53GL7	592	807	630	630	Natural variant	ID=VAR_027861;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs11544989,PMID:14702039
PARP10	Q53GL7	60	145	59	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHX
PARP10	Q53GL7	60	145	72	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHX
PARP10	Q53GL7	60	145	79	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHX
PARVA	Q9NVD7	173	220	2	372	Chain	ID=PRO_0000121580;Note=Alpha-parvin
PARVA	Q9NVD7	306	329	2	372	Chain	ID=PRO_0000121580;Note=Alpha-parvin
PARVA	Q9NVD7	173	220	95	202	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
PARVA	Q9NVD7	306	329	262	369	Domain	Note=Calponin-homology (CH) 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
PARVA	Q9NVD7	173	220	134	182	Alternative sequence	ID=VSP_008884;Note=In isoform 2. EKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSV->GRRVECCNGCVFNCRWLDHLLVARRSYSQFTVAYLEMDYKCVEHGITAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARVA	Q9NVD7	173	220	183	372	Alternative sequence	ID=VSP_008885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARVA	Q9NVD7	306	329	183	372	Alternative sequence	ID=VSP_008885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PARVA	Q9NVD7	306	329	310	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZG
PARVA	Q9NVD7	306	329	320	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VZC
PDCD6	O75340	69	122	2	191	Chain	ID=PRO_0000073729;Note=Programmed cell death protein 6
PDCD6	O75340	69	122	59	89	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PDCD6	O75340	69	122	90	125	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PDCD6	O75340	69	122	73	84	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
PDCD6	O75340	69	122	103	114	Calcium binding	Note=3;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18940611,ECO:0000269|PubMed:18997320,ECO:0000269|PubMed:20691033,ECO:0000269|PubMed:25667979;Dbxref=PMID:18940611,PMID:18997320,PMID:20691033,PMID:25667979
PDCD6	O75340	69	122	103	103	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18940611,ECO:0000269|PubMed:18997320,ECO:0000269|PubMed:20691033,ECO:0000269|PubMed:25667979;Dbxref=PMID:18940611,PMID:18997320,PMID:20691033,PMID:25667979
PDCD6	O75340	69	122	105	105	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18940611,ECO:0000269|PubMed:18997320,ECO:0000269|PubMed:20691033,ECO:0000269|PubMed:25667979;Dbxref=PMID:18940611,PMID:18997320,PMID:20691033,PMID:25667979
PDCD6	O75340	69	122	107	107	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18940611,ECO:0000269|PubMed:18997320,ECO:0000269|PubMed:20691033,ECO:0000269|PubMed:25667979;Dbxref=PMID:18940611,PMID:18997320,PMID:20691033,PMID:25667979
PDCD6	O75340	69	122	109	109	Metal binding	Note=Calcium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18940611,ECO:0000269|PubMed:18997320,ECO:0000269|PubMed:20691033,ECO:0000269|PubMed:25667979;Dbxref=PMID:18940611,PMID:18997320,PMID:20691033,PMID:25667979
PDCD6	O75340	69	122	114	114	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18940611,ECO:0000269|PubMed:18997320,ECO:0000269|PubMed:20691033,ECO:0000269|PubMed:25667979;Dbxref=PMID:18940611,PMID:18997320,PMID:20691033,PMID:25667979
PDCD6	O75340	69	122	70	191	Alternative sequence	ID=VSP_045542;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDCD6	O75340	69	122	121	122	Alternative sequence	ID=VSP_045113;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDCD6	O75340	69	122	85	85	Mutagenesis	Note=Stronly impaired interaction with SEC31A and TFG. Does not affect interaction with PDCD6IP. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25667979,ECO:0000269|PubMed:27813252;Dbxref=PMID:25667979,PMID:27813252
PDCD6	O75340	69	122	89	89	Mutagenesis	Note=Does not affect interaction with SEC31A. Does not affect interaction with PDCD6IP. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25667979;Dbxref=PMID:25667979
PDCD6	O75340	69	122	91	91	Mutagenesis	Note=Abolishes the interaction with PDCD6IP%2C ANXA7 and ANXA11. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18256029;Dbxref=PMID:18256029
PDCD6	O75340	69	122	92	92	Mutagenesis	Note=Does not affect interaction with SEC31A. Does not affect interaction with PDCD6IP. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25667979;Dbxref=PMID:25667979
PDCD6	O75340	69	122	95	95	Mutagenesis	Note=Abolishes the interaction with PDCD6IP%2C ANXA7 and ANXA11. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18256029;Dbxref=PMID:18256029
PDCD6	O75340	69	122	114	114	Mutagenesis	Note=Loss of interaction with SEC31A and PLSCR3%2C and loss of localization to the endoplasmic reticulum%3B when associated with A-47. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16957052,ECO:0000269|PubMed:18256029;Dbxref=PMID:16957052,PMID:18256029
PDCD6	O75340	69	122	122	122	Mutagenesis	Note=Increases interaction with PDCD6IP and ANXA7. Impairs interaction with ANXA11. Augments stauroporine-induced cell death. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691033;Dbxref=PMID:20691033
PDCD6	O75340	69	122	122	122	Mutagenesis	Note=Increases interaction with PDCD6IP. Impairs interaction with ANXA11. F->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691033;Dbxref=PMID:20691033
PDCD6	O75340	69	122	122	122	Mutagenesis	Note=Increases interaction with PDCD6IP. Impairs interaction with ANAX7 and ANXA11. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691033;Dbxref=PMID:20691033
PDCD6	O75340	69	122	122	122	Mutagenesis	Note=Impairs interaction with ANXA11. F->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691033;Dbxref=PMID:20691033
PDCD6	O75340	69	122	62	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZND
PDCD6	O75340	69	122	74	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZND
PDCD6	O75340	69	122	82	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZND
PDCD6	O75340	69	122	107	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZND
PDCD6	O75340	69	122	112	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZND
PDE7A	Q13946	232	276	1	482	Chain	ID=PRO_0000198833;Note=High affinity cAMP-specific 3'%2C5'-cyclic phosphodiesterase 7A
PDE7A	Q13946	66	94	1	482	Chain	ID=PRO_0000198833;Note=High affinity cAMP-specific 3'%2C5'-cyclic phosphodiesterase 7A
PDE7A	Q13946	232	276	136	458	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE7A	Q13946	232	276	252	252	Metal binding	Note=Divalent metal cation 1
PDE7A	Q13946	232	276	253	253	Metal binding	Note=Divalent metal cation 1
PDE7A	Q13946	232	276	253	253	Metal binding	Note=Divalent metal cation 2
PDE7A	Q13946	66	94	84	84	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDE7A	Q13946	66	94	76	76	Natural variant	ID=VAR_056661;Note=G->E;Dbxref=dbSNP:rs11557049
PDE7A	Q13946	232	276	231	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKL
PDE7A	Q13946	232	276	239	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKL
PDE7A	Q13946	232	276	252	255	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKL
PDE7A	Q13946	232	276	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKL
PDE7A	Q13946	232	276	270	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKL
PDE7A	Q13946	232	276	275	277	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZKL
PDE8B	O95263	113	133	1	885	Chain	ID=PRO_0000198840;Note=High affinity cAMP-specific and IBMX-insensitive 3'%2C5'-cyclic phosphodiesterase 8B
PDE8B	O95263	292	339	1	885	Chain	ID=PRO_0000198840;Note=High affinity cAMP-specific and IBMX-insensitive 3'%2C5'-cyclic phosphodiesterase 8B
PDE8B	O95263	455	510	1	885	Chain	ID=PRO_0000198840;Note=High affinity cAMP-specific and IBMX-insensitive 3'%2C5'-cyclic phosphodiesterase 8B
PDE8B	O95263	750	806	1	885	Chain	ID=PRO_0000198840;Note=High affinity cAMP-specific and IBMX-insensitive 3'%2C5'-cyclic phosphodiesterase 8B
PDE8B	O95263	292	339	267	338	Domain	Note=PAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
PDE8B	O95263	750	806	539	875	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE8B	O95263	750	806	781	781	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60658
PDE8B	O95263	750	806	754	754	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9Q4S1
PDE8B	O95263	113	133	1	535	Alternative sequence	ID=VSP_008081;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PDE8B	O95263	292	339	1	535	Alternative sequence	ID=VSP_008081;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PDE8B	O95263	455	510	1	535	Alternative sequence	ID=VSP_008081;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PDE8B	O95263	113	133	114	133	Alternative sequence	ID=VSP_008082;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12681444;Dbxref=PMID:12681444
PDE8B	O95263	292	339	293	389	Alternative sequence	ID=VSP_008084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12372422,ECO:0000303|PubMed:12681444;Dbxref=PMID:12372422,PMID:12681444
PDE8B	O95263	292	339	293	339	Alternative sequence	ID=VSP_008083;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12372422;Dbxref=PMID:12372422
PDE8B	O95263	455	510	456	510	Alternative sequence	ID=VSP_008085;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12681444;Dbxref=PMID:12681444
PDE8B	O95263	292	339	305	305	Natural variant	ID=VAR_066503;Note=In PPNAD3%3B shows significantly higher cyclic AMP levels after transfection with the mutant protein than after transfection with the wild-type%2C indicating an impaired ability of the mutant protein to degrade cAMP. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18431404;Dbxref=dbSNP:rs121918360,PMID:18431404
P4HB	P07237	453	482	18	508	Chain	ID=PRO_0000034195;Note=Protein disulfide-isomerase
P4HB	P07237	243	285	18	508	Chain	ID=PRO_0000034195;Note=Protein disulfide-isomerase
P4HB	P07237	208	243	18	508	Chain	ID=PRO_0000034195;Note=Protein disulfide-isomerase
P4HB	P07237	453	482	349	475	Domain	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
P4HB	P07237	453	482	461	461	Site	Note=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250
P4HB	P07237	208	243	222	222	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103
P4HB	P07237	243	285	271	271	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103
P4HB	P07237	453	482	460	460	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P4HB	P07237	453	482	481	481	Sequence conflict	Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
P4HB	P07237	208	243	199	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P4HB	P07237	208	243	212	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P4HB	P07237	208	243	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P4HB	P07237	208	243	237	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	242	244	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	208	243	242	244	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	245	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	250	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	255	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	265	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	268	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	243	285	281	285	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P4HB	P07237	453	482	463	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UEM
P4HB	P07237	453	482	471	473	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UEM
PDE6B	P35913	353	369	2	851	Chain	ID=PRO_0000023348;Note=Rod cGMP-specific 3'%2C5'-cyclic phosphodiesterase subunit beta
PDE6B	P35913	489	538	2	851	Chain	ID=PRO_0000023348;Note=Rod cGMP-specific 3'%2C5'-cyclic phosphodiesterase subunit beta
PDE6B	P35913	731	756	2	851	Chain	ID=PRO_0000023348;Note=Rod cGMP-specific 3'%2C5'-cyclic phosphodiesterase subunit beta
PDE6B	P35913	353	369	252	429	Domain	Note=GAF 2
PDE6B	P35913	489	538	481	814	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE6B	P35913	731	756	481	814	Domain	Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192
PDE6B	P35913	489	538	527	527	Natural variant	ID=VAR_009290;Note=In RP40%3B autosomal recessive. L->P;Dbxref=dbSNP:rs760766981
PDE6B	P35913	489	538	535	535	Natural variant	ID=VAR_009291;Note=In RP40%3B autosomal recessive. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9543643;Dbxref=dbSNP:rs527236088,PMID:9543643
PDE6B	P35913	353	369	360	360	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
POLDIP2	Q9Y2S7	261	303	1	368	Chain	ID=PRO_0000197975;Note=Polymerase delta-interacting protein 2
POLDIP2	Q9Y2S7	261	303	235	360	Domain	Note=ApaG;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00412
POLDIP2	Q9Y2S7	261	303	292	292	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PDK1	Q15118	113	136	29	436	Chain	ID=PRO_0000023437;Note=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1%2C mitochondrial
PDK1	Q15118	230	256	29	436	Chain	ID=PRO_0000023437;Note=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1%2C mitochondrial
PDK1	Q15118	315	352	29	436	Chain	ID=PRO_0000023437;Note=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1%2C mitochondrial
PDK1	Q15118	113	136	29	436	Chain	ID=PRO_0000023437;Note=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1%2C mitochondrial
PDK1	Q15118	230	256	29	436	Chain	ID=PRO_0000023437;Note=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1%2C mitochondrial
PDK1	Q15118	315	352	29	436	Chain	ID=PRO_0000023437;Note=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1%2C mitochondrial
PDK1	Q15118	230	256	163	393	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK1	Q15118	315	352	163	393	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK1	Q15118	230	256	163	393	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK1	Q15118	315	352	163	393	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
PDK1	Q15118	315	352	337	338	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDK1	Q15118	315	352	337	338	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDK1	Q15118	315	352	318	318	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDK1	Q15118	315	352	318	318	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDK1	Q15118	113	136	136	136	Modified residue	Note=Phosphotyrosine%3B by FGFR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22195962;Dbxref=PMID:22195962
PDK1	Q15118	113	136	136	136	Modified residue	Note=Phosphotyrosine%3B by FGFR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22195962;Dbxref=PMID:22195962
PDK1	Q15118	230	256	243	243	Modified residue	Note=Phosphotyrosine%3B by FGFR1%2C ABL1%2C FLT3 and JAK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22195962;Dbxref=PMID:22195962
PDK1	Q15118	230	256	243	243	Modified residue	Note=Phosphotyrosine%3B by FGFR1%2C ABL1%2C FLT3 and JAK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22195962;Dbxref=PMID:22195962
PDK1	Q15118	230	256	244	244	Modified residue	Note=Phosphotyrosine%3B by FGFR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22195962;Dbxref=PMID:22195962
PDK1	Q15118	230	256	244	244	Modified residue	Note=Phosphotyrosine%3B by FGFR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22195962;Dbxref=PMID:22195962
PDK1	Q15118	113	136	134	134	Natural variant	ID=VAR_050477;Note=A->T;Dbxref=dbSNP:rs35661499
PDK1	Q15118	113	136	134	134	Natural variant	ID=VAR_050477;Note=A->T;Dbxref=dbSNP:rs35661499
PDK1	Q15118	113	136	105	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	113	136	105	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	113	136	125	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	113	136	125	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	113	136	132	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	113	136	132	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	230	256	225	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	230	256	225	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	230	256	250	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	230	256	250	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	309	318	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	309	318	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	325	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	325	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	329	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	329	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	334	337	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	334	337	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8G
PDK1	Q15118	315	352	352	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8H
PDK1	Q15118	315	352	352	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q8H
PEAR1	Q5VY43	34	68	21	1037	Chain	ID=PRO_0000309737;Note=Platelet endothelial aggregation receptor 1
PEAR1	Q5VY43	608	650	21	1037	Chain	ID=PRO_0000309737;Note=Platelet endothelial aggregation receptor 1
PEAR1	Q5VY43	34	68	21	1037	Chain	ID=PRO_0000309737;Note=Platelet endothelial aggregation receptor 1
PEAR1	Q5VY43	608	650	21	1037	Chain	ID=PRO_0000309737;Note=Platelet endothelial aggregation receptor 1
PEAR1	Q5VY43	34	68	21	755	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	608	650	21	755	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	34	68	21	755	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	608	650	21	755	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	34	68	25	103	Domain	Note=EMI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00384
PEAR1	Q5VY43	34	68	25	103	Domain	Note=EMI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00384
PEAR1	Q5VY43	608	650	615	649	Domain	Note=EGF-like 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
PEAR1	Q5VY43	608	650	615	649	Domain	Note=EGF-like 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
PEAR1	Q5VY43	608	650	634	634	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	608	650	634	634	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	34	68	29	91	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	34	68	29	91	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	34	68	55	65	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	34	68	55	65	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
PEAR1	Q5VY43	608	650	619	630	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PEAR1	Q5VY43	608	650	619	630	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PEAR1	Q5VY43	608	650	624	637	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PEAR1	Q5VY43	608	650	624	637	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PEAR1	Q5VY43	608	650	639	648	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PEAR1	Q5VY43	608	650	639	648	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PDZD2	O15018	418	469	1	2839	Chain	ID=PRO_0000058294;Note=PDZ domain-containing protein 2
PDZD2	O15018	2615	2649	1	2839	Chain	ID=PRO_0000058294;Note=PDZ domain-containing protein 2
PDZD2	O15018	2615	2649	2493	2839	Chain	ID=PRO_0000302756;Note=Processed PDZ domain-containing protein 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PDZD2	O15018	418	469	334	419	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PDZD2	O15018	2615	2649	2622	2706	Domain	Note=PDZ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PDZD2	O15018	418	469	375	555	Alternative sequence	ID=VSP_012369;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11289102;Dbxref=PMID:11289102
PDZD4	Q76G19	217	254	1	769	Chain	ID=PRO_0000055921;Note=PDZ domain-containing protein 4
PDZD4	Q76G19	217	254	236	236	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
RAC2	P15153	75	96	1	189	Chain	ID=PRO_0000042046;Note=Ras-related C3 botulinum toxin substrate 2
RAC2	P15153	75	96	77	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W2T
RAC2	P15153	75	96	87	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W2T
PGAP1	Q75T13	842	876	1	922	Chain	ID=PRO_0000277623;Note=GPI inositol-deacylase
PGAP1	Q75T13	842	876	839	853	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP1	Q75T13	842	876	854	874	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP1	Q75T13	842	876	875	893	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP1	Q75T13	842	876	593	922	Alternative sequence	ID=VSP_023043;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PGAP1	Q75T13	842	876	652	922	Alternative sequence	ID=VSP_023044;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BCAN	Q96GW7	432	647	23	911	Chain	ID=PRO_0000017511;Note=Brevican core protein
BCAN	Q96GW7	647	683	23	911	Chain	ID=PRO_0000017511;Note=Brevican core protein
BCAN	Q96GW7	683	736	23	911	Chain	ID=PRO_0000017511;Note=Brevican core protein
BCAN	Q96GW7	432	647	646	682	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
BCAN	Q96GW7	647	683	646	682	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
BCAN	Q96GW7	683	736	695	809	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
BCAN	Q96GW7	432	647	520	530	Region	Note=O-glycosylated at two sites
BCAN	Q96GW7	432	647	540	545	Region	Note=O-glycosylated at two sites
BCAN	Q96GW7	432	647	569	575	Region	Note=O-glycosylated at one site
BCAN	Q96GW7	432	647	385	477	Compositional bias	Note=Glu-rich
BCAN	Q96GW7	647	683	650	661	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BCAN	Q96GW7	647	683	655	670	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BCAN	Q96GW7	647	683	672	681	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BCAN	Q96GW7	683	736	688	699	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BCAN	Q96GW7	683	736	716	808	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BCAN	Q96GW7	647	683	649	671	Alternative sequence	ID=VSP_011184;Note=In isoform 2. DCVPSPCHNGGTCLEEEEGVRCL->NSAQGSTALSILLLFFPLQLWVT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11054543;Dbxref=PMID:11054543
BCAN	Q96GW7	647	683	672	911	Alternative sequence	ID=VSP_011185;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11054543;Dbxref=PMID:11054543
BCAN	Q96GW7	683	736	672	911	Alternative sequence	ID=VSP_011185;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11054543;Dbxref=PMID:11054543
BCAN	Q96GW7	432	647	504	504	Natural variant	ID=VAR_019551;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs1056695,PMID:12975309
RAD21	O60216	540	568	1	631	Chain	ID=PRO_0000097872;Note=Double-strand-break repair protein rad21 homolog
RAD21	O60216	229	271	1	631	Chain	ID=PRO_0000097872;Note=Double-strand-break repair protein rad21 homolog
RAD21	O60216	229	271	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RAD21	O60216	540	568	545	545	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RAF1	P04049	556	601	1	648	Chain	ID=PRO_0000086596;Note=RAF proto-oncogene serine/threonine-protein kinase
RAF1	P04049	398	456	1	648	Chain	ID=PRO_0000086596;Note=RAF proto-oncogene serine/threonine-protein kinase
RAF1	P04049	194	226	1	648	Chain	ID=PRO_0000086596;Note=RAF proto-oncogene serine/threonine-protein kinase
RAF1	P04049	556	601	349	609	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RAF1	P04049	398	456	349	609	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RAF1	P04049	556	601	563	563	Modified residue	Note=Symmetric dimethylarginine%3B by PRMT5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21917714;Dbxref=PMID:21917714
RAF1	P04049	556	601	563	563	Mutagenesis	Note=Loss of methylation. Increased stability and catalytic activity in response to EGF treatment. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21917714;Dbxref=PMID:21917714
PGS1	Q32NB8	111	137	29	556	Chain	ID=PRO_0000337105;Note=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase%2C mitochondrial
PGS1	Q32NB8	293	467	29	556	Chain	ID=PRO_0000337105;Note=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase%2C mitochondrial
PGS1	Q32NB8	293	467	460	493	Domain	Note=PLD phosphodiesterase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00153
PGS1	Q32NB8	111	137	124	131	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGS1	Q32NB8	111	137	51	556	Alternative sequence	ID=VSP_033898;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PGS1	Q32NB8	293	467	51	556	Alternative sequence	ID=VSP_033898;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PGS1	Q32NB8	111	137	112	137	Alternative sequence	ID=VSP_033899;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PGS1	Q32NB8	293	467	328	330	Alternative sequence	ID=VSP_033900;Note=In isoform 3. SNS->RTL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PGS1	Q32NB8	293	467	331	556	Alternative sequence	ID=VSP_033901;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHAX	Q9H814	277	305	2	394	Chain	ID=PRO_0000239775;Note=Phosphorylated adapter RNA export protein
PHAX	Q9H814	277	305	2	329	Region	Note=Necessary for interaction with CBP80;Ontology_term=ECO:0000250;evidence=ECO:0000250
PHAX	Q9H814	277	305	228	328	Region	Note=Sufficient for poly U RNA-binding
PHAX	Q9H814	277	305	279	287	Region	Note=Necessary for poly U RNA-binding and snRNA export;Ontology_term=ECO:0000250;evidence=ECO:0000250
PHAX	Q9H814	277	305	296	296	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PHAX	Q9H814	277	305	277	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XC7
PHAX	Q9H814	277	305	285	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XC7
PHAX	Q9H814	277	305	301	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XC7
PHF10	Q8WUB8	407	470	2	498	Chain	ID=PRO_0000059297;Note=PHD finger protein 10
PHF10	Q8WUB8	319	371	2	498	Chain	ID=PRO_0000059297;Note=PHD finger protein 10
PHF10	Q8WUB8	181	231	2	498	Chain	ID=PRO_0000059297;Note=PHD finger protein 10
PHF10	Q8WUB8	108	136	2	498	Chain	ID=PRO_0000059297;Note=PHD finger protein 10
PHF10	Q8WUB8	407	470	379	436	Zinc finger	Note=PHD-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
PHF10	Q8WUB8	407	470	438	481	Zinc finger	Note=PHD-type 2%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
PHF10	Q8WUB8	181	231	89	295	Region	Note=SAY
PHF10	Q8WUB8	108	136	89	295	Region	Note=SAY
PHF10	Q8WUB8	181	231	89	185	Region	Note=Essential to induce neural progenitor proliferation;Ontology_term=ECO:0000250;evidence=ECO:0000250
PHF10	Q8WUB8	108	136	89	185	Region	Note=Essential to induce neural progenitor proliferation;Ontology_term=ECO:0000250;evidence=ECO:0000250
PHF10	Q8WUB8	319	371	292	334	Region	Note=Essential to induce neural progenitor proliferation;Ontology_term=ECO:0000250;evidence=ECO:0000250
PHF10	Q8WUB8	319	371	327	327	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163
PHF10	Q8WUB8	319	371	331	331	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D8M7
PHF10	Q8WUB8	108	136	109	110	Alternative sequence	ID=VSP_013440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHF10	Q8WUB8	108	136	126	126	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF10	Q8WUB8	319	371	325	325	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF10	Q8WUB8	319	371	332	332	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF10	Q8WUB8	319	371	357	357	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF10	Q8WUB8	319	371	365	365	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF10	Q8WUB8	407	470	422	422	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF1	O43189	80	112	1	567	Chain	ID=PRO_0000059288;Note=PHD finger protein 1
PHF1	O43189	196	227	1	567	Chain	ID=PRO_0000059288;Note=PHD finger protein 1
PHF1	O43189	445	471	1	567	Chain	ID=PRO_0000059288;Note=PHD finger protein 1
PHF1	O43189	80	112	29	86	Domain	Note=Tudor
PHF1	O43189	80	112	87	142	Zinc finger	Note=PHD-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
PHF1	O43189	196	227	186	240	Zinc finger	Note=PHD-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
PHF1	O43189	445	471	350	457	Alternative sequence	ID=VSP_004694;Note=In isoform 1. SFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPS->RAGPWGRGLTSPGEAPEAGARAPEEEAEGESGGAGATLSSAQSARAPGAEGAGSSAEGTAAAPSGCLLPSTLLPAPQGPLGTVDPQTGHPWNFTLVSPQTSLKVPPTR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9545646;Dbxref=PMID:9545646
PHF1	O43189	445	471	458	567	Alternative sequence	ID=VSP_004695;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9545646;Dbxref=PMID:9545646
PHF1	O43189	80	112	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HCZ
PHF1	O43189	80	112	87	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFO
PHF1	O43189	80	112	91	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	80	112	104	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	80	112	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	196	227	197	200	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	196	227	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	196	227	205	207	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	196	227	210	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
PHF1	O43189	196	227	213	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XFN
RASSF2	P50749	179	213	1	326	Chain	ID=PRO_0000097172;Note=Ras association domain-containing protein 2
RASSF2	P50749	179	213	1	326	Chain	ID=PRO_0000097172;Note=Ras association domain-containing protein 2
RASSF2	P50749	179	213	176	264	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
RASSF2	P50749	179	213	176	264	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
PHLDB2	Q86SQ0	667	710	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	799	829	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	829	877	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	877	924	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	1056	1105	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	667	710	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	799	829	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	829	877	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	877	924	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	1056	1105	1	1253	Chain	ID=PRO_0000053894;Note=Pleckstrin homology-like domain family B member 2
PHLDB2	Q86SQ0	667	710	584	696	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB2	Q86SQ0	667	710	584	696	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB2	Q86SQ0	799	829	722	807	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB2	Q86SQ0	799	829	722	807	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB2	Q86SQ0	1056	1105	1032	1098	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB2	Q86SQ0	1056	1105	1032	1098	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB2	Q86SQ0	877	924	898	898	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
PHLDB2	Q86SQ0	877	924	898	898	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
PHLDB2	Q86SQ0	667	710	668	710	Alternative sequence	ID=VSP_016745;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PHLDB2	Q86SQ0	667	710	668	710	Alternative sequence	ID=VSP_016745;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
PHLDB3	Q6NSJ2	317	345	1	640	Chain	ID=PRO_0000053896;Note=Pleckstrin homology-like domain family B member 3
PHLDB3	Q6NSJ2	178	221	1	640	Chain	ID=PRO_0000053896;Note=Pleckstrin homology-like domain family B member 3
PHLDB3	Q6NSJ2	132	178	1	640	Chain	ID=PRO_0000053896;Note=Pleckstrin homology-like domain family B member 3
PHLDB3	Q6NSJ2	317	345	104	327	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB3	Q6NSJ2	178	221	104	327	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB3	Q6NSJ2	132	178	104	327	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHLDB3	Q6NSJ2	317	345	280	640	Alternative sequence	ID=VSP_039924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PHLPP1	O60346	591	633	1	1717	Chain	ID=PRO_0000057781;Note=PH domain leucine-rich repeat-containing protein phosphatase 1
PHLPP1	O60346	987	1053	1	1717	Chain	ID=PRO_0000057781;Note=PH domain leucine-rich repeat-containing protein phosphatase 1
PHLPP1	O60346	1187	1251	1	1717	Chain	ID=PRO_0000057781;Note=PH domain leucine-rich repeat-containing protein phosphatase 1
PHLPP1	O60346	591	633	536	636	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PHLPP1	O60346	987	1053	987	1008	Repeat	Note=LRR 15
PHLPP1	O60346	987	1053	1013	1033	Repeat	Note=LRR 16
PHLPP1	O60346	987	1053	1037	1058	Repeat	Note=LRR 17
PHLPP1	O60346	1187	1251	1175	1422	Domain	Note=PPM-type phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01082
PHLPP1	O60346	1187	1251	1076	1205	Region	Note=Interaction with SLC9A3R1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21804599;Dbxref=PMID:21804599
PHLPP1	O60346	1187	1251	1210	1210	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813
PHLPP1	O60346	1187	1251	1210	1210	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813
PHLPP1	O60346	1187	1251	1211	1211	Metal binding	Note=Manganese 1%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813
PHLPP1	O60346	1187	1251	1227	1227	Sequence conflict	Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHLPP2	Q6ZVD8	595	661	1	1323	Chain	ID=PRO_0000057784;Note=PH domain leucine-rich repeat-containing protein phosphatase 2
PHLPP2	Q6ZVD8	203	245	1	1323	Chain	ID=PRO_0000057784;Note=PH domain leucine-rich repeat-containing protein phosphatase 2
PHLPP2	Q6ZVD8	203	245	150	248	Domain	Note=PH
PHLPP2	Q6ZVD8	595	661	595	616	Repeat	Note=LRR 16
PHLPP2	Q6ZVD8	595	661	621	644	Repeat	Note=LRR 17
PHLPP2	Q6ZVD8	595	661	645	666	Repeat	Note=LRR 18
PHLPP2	Q6ZVD8	595	661	596	662	Alternative sequence	ID=VSP_017265;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
RAVER2	Q9HCJ3	397	432	2	691	Chain	ID=PRO_0000081490;Note=Ribonucleoprotein PTB-binding 2
RAVER2	Q9HCJ3	397	432	397	409	Alternative sequence	ID=VSP_013676;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
RAB11A	P62491	143	170	2	213	Chain	ID=PRO_0000121151;Note=Ras-related protein Rab-11A
RAB11A	P62491	143	170	154	156	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16905101,ECO:0000269|PubMed:17007872,ECO:0000269|PubMed:17030804;Dbxref=PMID:16905101,PMID:17007872,PMID:17030804
RAB11A	P62491	143	170	147	216	Alternative sequence	ID=VSP_046755;Note=In isoform 2. GLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI->EANVRQTRK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB11A	P62491	143	170	136	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OIX
RAB11A	P62491	143	170	149	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OIX
RAB11A	P62491	143	170	155	157	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OIX
RAB11A	P62491	143	170	161	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OIX
RAB1B	Q9H0U4	61	93	1	201	Chain	ID=PRO_0000121061;Note=Ras-related protein Rab-1B
RAB1B	Q9H0U4	61	93	63	67	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3NKV,ECO:0000244|PDB:5SZH,ECO:0000244|PDB:5SZK,ECO:0000269|PubMed:20651120,ECO:0000269|PubMed:27552051;Dbxref=PMID:20651120,PMID:27552051
RAB1B	Q9H0U4	61	93	64	83	Region	Note=Switch 2 region%3B required for interaction with REP1/CHM
RAB1B	Q9H0U4	61	93	76	76	Modified residue	Note=O-(2-cholinephosphoryl)serine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21822290,ECO:0000269|PubMed:22158903,ECO:0000269|PubMed:22307087;Dbxref=PMID:21822290,PMID:22158903,PMID:22307087
RAB1B	Q9H0U4	61	93	77	77	Modified residue	Note=O-AMP-tyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20651120;Dbxref=PMID:20651120
RAB1B	Q9H0U4	61	93	67	67	Mutagenesis	Note=No effect on GDI1 binding. Reduces prenylation in vitro%2C but not in vivo. No effect on interaction with REP1/CHM%3B 100-fold refunction in intrinsic GTPase activity. Q->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23236136,ECO:0000269|PubMed:8836150,ECO:0000269|PubMed:9437002;Dbxref=PMID:23236136,PMID:8836150,PMID:9437002
RAB1B	Q9H0U4	61	93	73	73	Mutagenesis	Note=Abolishes interaction with REP1/CHM. No prenylation. Much lower GDP/GTP ratio. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9437002;Dbxref=PMID:9437002
RAB1B	Q9H0U4	61	93	76	76	Mutagenesis	Note=Abolishes phosphocholination by Legionella AnkX. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21822290;Dbxref=PMID:21822290
RAB1B	Q9H0U4	61	93	77	77	Mutagenesis	Note=Abolishes AMPylation by Legionella DrrA. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20651120;Dbxref=PMID:20651120
RAB1B	Q9H0U4	61	93	78	78	Mutagenesis	Note=Abolishes interaction with REP1/CHM and GDI1. No prenylation. Much lower GDP/GTP ratio. No membrane association. Y->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11389151,ECO:0000269|PubMed:9437002;Dbxref=PMID:11389151,PMID:9437002
RAB1B	Q9H0U4	61	93	81	81	Mutagenesis	Note=Abolishes interaction with REP1/CHM. No prenylation. Lowers GDP/GTP ratio by half. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9437002;Dbxref=PMID:9437002
RAB1B	Q9H0U4	61	93	55	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKV
RAB1B	Q9H0U4	61	93	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKV
RAB1B	Q9H0U4	61	93	71	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKV
RAB1B	Q9H0U4	61	93	76	80	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKV
RAB1B	Q9H0U4	61	93	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKV
RAB1B	Q9H0U4	61	93	93	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NKV
RAB26	Q9ULW5	65	102	1	256	Chain	ID=PRO_0000121218;Note=Ras-related protein Rab-26
RAB26	Q9ULW5	65	102	70	78	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10
RAB26	Q9ULW5	65	102	93	101	Motif	Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB26	Q9ULW5	65	102	1	66	Alternative sequence	ID=VSP_056879;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB26	Q9ULW5	65	102	77	77	Mutagenesis	Note=Inactive%2C constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. T->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20038531,ECO:0000269|PubMed:23105096;Dbxref=PMID:20038531,PMID:23105096
RAB26	Q9ULW5	65	102	61	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B
RAB26	Q9ULW5	65	102	76	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B
RAB26	Q9ULW5	65	102	100	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B
RAB30	Q15771	31	59	1	200	Chain	ID=PRO_0000121230;Note=Ras-related protein Rab-30
RAB30	Q15771	31	59	1	200	Chain	ID=PRO_0000121230;Note=Ras-related protein Rab-30
RAB30	Q15771	31	59	1	200	Chain	ID=PRO_0000121230;Note=Ras-related protein Rab-30
RAB30	Q15771	31	59	38	46	Motif	Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB30	Q15771	31	59	38	46	Motif	Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB30	Q15771	31	59	38	46	Motif	Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB30	Q15771	31	59	45	45	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB30	Q15771	31	59	45	45	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB30	Q15771	31	59	45	45	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB30	Q15771	31	59	22	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	22	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	22	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	43	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	43	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	43	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	56	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	56	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB30	Q15771	31	59	56	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EW1
RAB37	Q96AX2	31	68	2	220	Chain	ID=PRO_0000121249;Note=Ras-related protein Rab-37
RAB37	Q96AX2	68	82	2	220	Chain	ID=PRO_0000121249;Note=Ras-related protein Rab-37
RAB37	Q96AX2	31	68	36	43	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB37	Q96AX2	31	68	59	67	Motif	Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB37	Q96AX2	31	68	1	68	Alternative sequence	ID=VSP_041268;Note=In isoform 2. MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFR->MDLQRPDSYQGGAGPDFNDHVLHKTILVGDSGVGKTSLLVQFDQGKFIPGSFSATVGIGFT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RAB37	Q96AX2	68	82	1	68	Alternative sequence	ID=VSP_041268;Note=In isoform 2. MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFR->MDLQRPDSYQGGAGPDFNDHVLHKTILVGDSGVGKTSLLVQFDQGKFIPGSFSATVGIGFT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RAB37	Q96AX2	31	68	32	68	Alternative sequence	ID=VSP_043156;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB37	Q96AX2	68	82	32	68	Alternative sequence	ID=VSP_043156;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PEX13	Q92968	262	304	1	403	Chain	ID=PRO_0000058323;Note=Peroxisomal membrane protein PEX13
PEX13	Q92968	262	304	252	403	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX13	Q92968	262	304	272	336	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
PEX6	Q13608	863	888	1	980	Chain	ID=PRO_0000084607;Note=Peroxisome assembly factor 2
PEX6	Q13608	349	376	1	980	Chain	ID=PRO_0000084607;Note=Peroxisome assembly factor 2
PEX6	Q13608	863	888	739	980	Alternative sequence	ID=VSP_057139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11355018;Dbxref=PMID:11355018
PEX6	Q13608	863	888	882	882	Natural variant	ID=VAR_048115;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19105186;Dbxref=dbSNP:rs2274516,PMID:19105186
RAB5A	P20339	105	146	1	215	Chain	ID=PRO_0000121104;Note=Ras-related protein Rab-5A
RAB5A	P20339	105	146	133	136	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1N6H,ECO:0000244|PDB:1N6L,ECO:0000244|PDB:1N6N,ECO:0000244|PDB:1N6O,ECO:0000244|PDB:1N6P,ECO:0000244|PDB:1N6R,ECO:0000244|PDB:1R2Q,ECO:0000244|PDB:1TU3,ECO:0000244|PDB:3MJH,ECO:0000269|PubMed:12433916,ECO:0000269|PubMed:14684892,ECO:0000269|PubMed:15378032,ECO:0000269|PubMed:20534488;Dbxref=PMID:12433916,PMID:14684892,PMID:15378032,PMID:20534488
RAB5A	P20339	105	146	116	116	Mutagenesis	Note=No effect on RABEP1 binding affinity. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15378032;Dbxref=PMID:15378032
RAB5A	P20339	105	146	120	120	Mutagenesis	Note=No effect on RABEP1 binding affinity. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15378032;Dbxref=PMID:15378032
RAB5A	P20339	105	146	105	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R2Q
RAB5A	P20339	105	146	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R2Q
RAB5A	P20339	105	146	135	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R2Q
RAB5A	P20339	105	146	145	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R2Q
RAB5B	P61020	105	146	2	215	Chain	ID=PRO_0000121107;Note=Ras-related protein Rab-5B
RAB5B	P61020	105	146	2	215	Chain	ID=PRO_0000121107;Note=Ras-related protein Rab-5B
RAB5B	P61020	105	146	133	136	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2HEI,ECO:0000269|Ref.14
RAB5B	P61020	105	146	133	136	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2HEI,ECO:0000269|Ref.14
RAB5B	P61020	105	146	106	146	Alternative sequence	ID=VSP_045301;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB5B	P61020	105	146	106	146	Alternative sequence	ID=VSP_045301;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB5B	P61020	105	146	105	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	105	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	135	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	135	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	145	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
RAB5B	P61020	105	146	145	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HEI
PFDN5	Q99471	69	94	2	154	Chain	ID=PRO_0000153661;Note=Prefoldin subunit 5
PFDN5	Q99471	69	94	2	154	Chain	ID=PRO_0000153661;Note=Prefoldin subunit 5
PFDN5	Q99471	69	94	25	69	Alternative sequence	ID=VSP_043103;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16173081;Dbxref=PMID:16173081
PFDN5	Q99471	69	94	25	69	Alternative sequence	ID=VSP_043103;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16173081;Dbxref=PMID:16173081
PFDN5	Q99471	69	94	59	154	Alternative sequence	ID=VSP_043104;Note=In isoform 2. GKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTALGAAQATAKA->DVCPWEAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16173081;Dbxref=PMID:16173081
PFDN5	Q99471	69	94	59	154	Alternative sequence	ID=VSP_043104;Note=In isoform 2. GKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTALGAAQATAKA->DVCPWEAA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16173081;Dbxref=PMID:16173081
PIGH	Q14442	130	158	1	188	Chain	ID=PRO_0000058435;Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
PIGH	Q14442	60	130	1	188	Chain	ID=PRO_0000058435;Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
PIGA	P37287	327	396	1	484	Chain	ID=PRO_0000080326;Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
PIGA	P37287	93	162	1	484	Chain	ID=PRO_0000080326;Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
PIGA	P37287	327	396	1	421	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGA	P37287	93	162	1	421	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGA	P37287	93	162	5	238	Alternative sequence	ID=VSP_043367;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIGA	P37287	93	162	115	283	Alternative sequence	ID=VSP_001802;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8081230;Dbxref=PMID:8081230
PIGA	P37287	93	162	93	93	Natural variant	ID=VAR_071070;Note=In MCAHS2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24259184;Dbxref=dbSNP:rs587777400,PMID:24259184
PIGA	P37287	93	162	119	119	Natural variant	ID=VAR_071071;Note=In MCAHS2. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24706016;Dbxref=dbSNP:rs587777396,PMID:24706016
PIGA	P37287	93	162	128	128	Natural variant	ID=VAR_015440;Note=In PNH1. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10087994;Dbxref=PMID:10087994
PIGA	P37287	93	162	135	135	Natural variant	ID=VAR_078230;Note=Probable disease-associated mutation found in a patient with infantile onset epileptic encephalopathy with dyskinesia and microcephaly. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27864847;Dbxref=PMID:27864847
PIGA	P37287	93	162	155	155	Natural variant	ID=VAR_005531;Note=In PNH1. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8306954;Dbxref=PMID:8306954
PIGA	P37287	327	396	344	344	Natural variant	ID=VAR_071073;Note=In MCAHS2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24259288;Dbxref=PMID:24259288
PIGA	P37287	327	396	355	355	Natural variant	ID=VAR_078721;Note=In MCAHS2%3B unknown pathological significance. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
PIAS4	Q8N2W9	180	193	2	510	Chain	ID=PRO_0000218982;Note=E3 SUMO-protein ligase PIAS4
PIAS4	Q8N2W9	180	193	119	279	Domain	Note=PINIT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00799
PIAS4	Q8N2W9	180	193	179	182	Sequence conflict	Note=SREL->FQGM;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIAS4	Q8N2W9	180	193	179	182	Sequence conflict	Note=SREL->FQGM;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIBF1	Q8WXW3	408	440	1	757	Chain	ID=PRO_0000058426;Note=Progesterone-induced-blocking factor 1
PIBF1	Q8WXW3	683	741	1	757	Chain	ID=PRO_0000058426;Note=Progesterone-induced-blocking factor 1
PIBF1	Q8WXW3	408	440	1	419	Region	Note=Mediates modulation of Th2 dominant cytokine production;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14634107;Dbxref=PMID:14634107
PIBF1	Q8WXW3	408	440	1	541	Alternative sequence	ID=VSP_015302;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15305375;Dbxref=PMID:15305375
PIBF1	Q8WXW3	408	440	104	757	Alternative sequence	ID=VSP_015304;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15305375;Dbxref=PMID:15305375
PIBF1	Q8WXW3	683	741	104	757	Alternative sequence	ID=VSP_015304;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15305375;Dbxref=PMID:15305375
PIBF1	Q8WXW3	408	440	225	683	Alternative sequence	ID=VSP_057956;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15305375;Dbxref=PMID:15305375
PIBF1	Q8WXW3	683	741	225	683	Alternative sequence	ID=VSP_057956;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15305375;Dbxref=PMID:15305375
PIN1	Q13526	19	90	1	163	Chain	ID=PRO_0000193435;Note=Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
PIN1	Q13526	19	90	1	163	Chain	ID=PRO_0000193435;Note=Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
PIN1	Q13526	19	90	5	39	Domain	Note=WW;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
PIN1	Q13526	19	90	5	39	Domain	Note=WW;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
PIN1	Q13526	19	90	52	163	Domain	Note=PpiC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00278
PIN1	Q13526	19	90	52	163	Domain	Note=PpiC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00278
PIN1	Q13526	19	90	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PIN1	Q13526	19	90	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PIN1	Q13526	19	90	46	46	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PIN1	Q13526	19	90	46	46	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PIN1	Q13526	19	90	71	71	Modified residue	Note=Phosphoserine%3B by DAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21497122;Dbxref=PMID:21497122
PIN1	Q13526	19	90	71	71	Modified residue	Note=Phosphoserine%3B by DAPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21497122;Dbxref=PMID:21497122
PIN1	Q13526	19	90	23	23	Mutagenesis	Note=Reduced affinity for KIF20B. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11470801;Dbxref=PMID:11470801
PIN1	Q13526	19	90	23	23	Mutagenesis	Note=Reduced affinity for KIF20B. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11470801;Dbxref=PMID:11470801
PIN1	Q13526	19	90	34	34	Mutagenesis	Note=Loss of binding to phosphorylated target proteins%2C including to phosphorylated RBBP8/CtIP%3B decrease in DNA repair of double-strand breaks by homologous recombination less efficient than that observed with wild-type protein. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22608923,ECO:0000269|PubMed:23623683;Dbxref=PMID:22608923,PMID:23623683
PIN1	Q13526	19	90	34	34	Mutagenesis	Note=Loss of binding to phosphorylated target proteins%2C including to phosphorylated RBBP8/CtIP%3B decrease in DNA repair of double-strand breaks by homologous recombination less efficient than that observed with wild-type protein. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22608923,ECO:0000269|PubMed:23623683;Dbxref=PMID:22608923,PMID:23623683
PIN1	Q13526	19	90	63	63	Mutagenesis	Note=Loss of peptidyl-prolyl cis/trans isomerase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22608923;Dbxref=PMID:22608923
PIN1	Q13526	19	90	63	63	Mutagenesis	Note=Loss of peptidyl-prolyl cis/trans isomerase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22608923;Dbxref=PMID:22608923
PIN1	Q13526	19	90	71	71	Mutagenesis	Note=Loss of peptidyl-prolyl cis/trans isomerase activity%2C nuclear localization and cellular function. S->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21497122;Dbxref=PMID:21497122
PIN1	Q13526	19	90	71	71	Mutagenesis	Note=Loss of peptidyl-prolyl cis/trans isomerase activity%2C nuclear localization and cellular function. S->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21497122;Dbxref=PMID:21497122
PIN1	Q13526	19	90	17	19	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TC5
PIN1	Q13526	19	90	17	19	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TC5
PIN1	Q13526	19	90	22	26	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PIN
PIN1	Q13526	19	90	22	26	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PIN
PIN1	Q13526	19	90	27	29	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PIN
PIN1	Q13526	19	90	27	29	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PIN
PIN1	Q13526	19	90	32	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PIN
PIN1	Q13526	19	90	32	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PIN
PIN1	Q13526	19	90	39	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I6C
PIN1	Q13526	19	90	39	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I6C
PIN1	Q13526	19	90	53	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	53	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	75	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	75	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	82	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PIN1	Q13526	19	90	82	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I6C
PITPNB	P48739	152	178	1	271	Chain	ID=PRO_0000191643;Note=Phosphatidylinositol transfer protein beta isoform
PITPNB	P48739	124	152	1	271	Chain	ID=PRO_0000191643;Note=Phosphatidylinositol transfer protein beta isoform
PINK1	Q9BXM7	259	319	78	581	Chain	ID=PRO_0000024369;Note=Serine/threonine-protein kinase PINK1%2C mitochondrial
PINK1	Q9BXM7	417	496	78	581	Chain	ID=PRO_0000024369;Note=Serine/threonine-protein kinase PINK1%2C mitochondrial
PINK1	Q9BXM7	259	319	111	581	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PINK1	Q9BXM7	417	496	111	581	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PINK1	Q9BXM7	259	319	156	511	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000305
PINK1	Q9BXM7	417	496	156	511	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000305
PINK1	Q9BXM7	259	319	1	307	Alternative sequence	ID=VSP_050754;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PINK1	Q9BXM7	259	319	308	320	Alternative sequence	ID=VSP_050755;Note=In isoform 2. LGHGRTLFLVMKN->MCGSQRPSPLSTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PINK1	Q9BXM7	259	319	263	263	Natural variant	ID=VAR_046583;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=PMID:15596610
PINK1	Q9BXM7	259	319	268	268	Natural variant	ID=VAR_046584;Note=In PARK6. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16207217,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs372280083,PMID:16207217,PMID:18330912
PINK1	Q9BXM7	259	319	271	271	Natural variant	ID=VAR_046585;Note=In PARK6. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15349870;Dbxref=dbSNP:rs28940284,PMID:15349870
PINK1	Q9BXM7	259	319	276	276	Natural variant	ID=VAR_046586;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs548506734,PMID:18330912
PINK1	Q9BXM7	259	319	279	279	Natural variant	ID=VAR_046587;Note=In PARK6. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15970950;Dbxref=dbSNP:rs74315358,PMID:15970950
PINK1	Q9BXM7	259	319	280	280	Natural variant	ID=VAR_062774;Note=In PARK6%3B early-onset. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16482571;Dbxref=dbSNP:rs772510148,PMID:16482571
PINK1	Q9BXM7	259	319	296	296	Natural variant	ID=VAR_046588;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15349860,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs779060308,PMID:15349860,PMID:18330912
PINK1	Q9BXM7	259	319	305	305	Natural variant	ID=VAR_018993;Note=P->L;Dbxref=dbSNP:rs7349186
PINK1	Q9BXM7	259	319	309	309	Natural variant	ID=VAR_018994;Note=In PARK6%3B fails to maintain mitochondrial membrane potential%3B full-length mutant has no effect on autophosphorylation%3B strongly reduces interaction with PRKN%3B decreases PRKN and SNCAIP ubiquitination and degradation. G->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15087508,ECO:0000269|PubMed:16207731,ECO:0000269|PubMed:19229105,ECO:0000269|PubMed:20798600;Dbxref=dbSNP:rs74315355,PMID:15087508,PMID:16207731,PMID:19229105,PMID:20798600
PINK1	Q9BXM7	259	319	313	313	Natural variant	ID=VAR_046589;Note=In PARK6%3B decreases PRKN and SNCAIP ubiquitination and degradation. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17030667,ECO:0000269|PubMed:19229105;Dbxref=dbSNP:rs74315359,PMID:17030667,PMID:19229105
PINK1	Q9BXM7	259	319	317	317	Natural variant	ID=VAR_046590;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16969854,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs200949139,PMID:16969854,PMID:18330912
PINK1	Q9BXM7	259	319	318	318	Natural variant	ID=VAR_046591;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=dbSNP:rs139226733,PMID:15596610
PINK1	Q9BXM7	417	496	417	417	Natural variant	ID=VAR_046599;Note=In PARK6. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15349870;Dbxref=PMID:15349870
PINK1	Q9BXM7	417	496	425	425	Natural variant	ID=VAR_046600;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=dbSNP:rs554114655,PMID:15596610
PINK1	Q9BXM7	417	496	431	431	Natural variant	ID=VAR_046601;Note=May predispose to Parkinson disease development%3B shows decreased mitochondrial membrane potential under stress conditions. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16969854;Dbxref=dbSNP:rs74315361,PMID:16969854
PINK1	Q9BXM7	417	496	442	442	Natural variant	ID=VAR_046602;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15349860,ECO:0000269|PubMed:18330912;Dbxref=PMID:15349860,PMID:18330912
PINK1	Q9BXM7	417	496	451	451	Natural variant	ID=VAR_046603;Note=May predispose to Parkinson disease development%3B shows decreased mitochondrial membrane potential under stress conditions. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16969854;Dbxref=dbSNP:rs747400197,PMID:16969854
PINK1	Q9BXM7	417	496	456	581	Natural variant	ID=VAR_078935;Note=In PARK6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24652937;Dbxref=PMID:24652937
PINK1	Q9BXM7	417	496	461	461	Natural variant	ID=VAR_046604;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16969854;Dbxref=PMID:16969854
PINK1	Q9BXM7	417	496	464	464	Natural variant	ID=VAR_046605;Note=In PARK6. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15349860;Dbxref=dbSNP:rs764328076,PMID:15349860
PINK1	Q9BXM7	417	496	476	476	Natural variant	ID=VAR_046606;Note=May predispose to Parkinson disease development%3B shows decreased mitochondrial membrane potential under stress conditions. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15349860,ECO:0000269|PubMed:15596610,ECO:0000269|PubMed:16009891,ECO:0000269|PubMed:16969854,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs115477764,PMID:15349860,PMID:15596610,PMID:16009891,PMID:16969854,PMID:18330912
PINK1	Q9BXM7	417	496	477	477	Natural variant	ID=VAR_041017;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34416410,PMID:17344846
PINK1	Q9BXM7	417	496	489	489	Natural variant	ID=VAR_046607;Note=In PARK6. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=PMID:15596610
PINK1	Q9BXM7	417	496	419	419	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLEKHG6	Q3KR16	98	153	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	153	185	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	252	289	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	557	787	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	98	153	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	153	185	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	252	289	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	557	787	1	790	Chain	ID=PRO_0000307912;Note=Pleckstrin homology domain-containing family G member 6
PLEKHG6	Q3KR16	153	185	161	353	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG6	Q3KR16	252	289	161	353	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG6	Q3KR16	153	185	161	353	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG6	Q3KR16	252	289	161	353	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
PLEKHG6	Q3KR16	557	787	714	718	Compositional bias	Note=Poly-Glu
PLEKHG6	Q3KR16	557	787	714	718	Compositional bias	Note=Poly-Glu
PLEKHG6	Q3KR16	98	153	1	470	Alternative sequence	ID=VSP_028856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PLEKHG6	Q3KR16	153	185	1	470	Alternative sequence	ID=VSP_028856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PLEKHG6	Q3KR16	252	289	1	470	Alternative sequence	ID=VSP_028856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PLEKHG6	Q3KR16	98	153	1	470	Alternative sequence	ID=VSP_028856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PLEKHG6	Q3KR16	153	185	1	470	Alternative sequence	ID=VSP_028856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PLEKHG6	Q3KR16	252	289	1	470	Alternative sequence	ID=VSP_028856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PIK3CB	P42338	527	590	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	510	527	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	267	324	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	207	267	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	527	590	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	510	527	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	267	324	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	207	267	1	1070	Chain	ID=PRO_0000088787;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit beta isoform
PIK3CB	P42338	267	324	194	285	Domain	Note=PI3K-RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00879
PIK3CB	P42338	207	267	194	285	Domain	Note=PI3K-RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00879
PIK3CB	P42338	267	324	194	285	Domain	Note=PI3K-RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00879
PIK3CB	P42338	207	267	194	285	Domain	Note=PI3K-RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00879
PIK3CB	P42338	527	590	524	701	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3CB	P42338	510	527	524	701	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3CB	P42338	527	590	524	701	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3CB	P42338	510	527	524	701	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PIK3CB	P42338	267	324	324	324	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTI9
PIK3CB	P42338	267	324	324	324	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BTI9
PIR	O00625	188	203	1	290	Chain	ID=PRO_0000214051;Note=Pirin
PIR	O00625	63	91	1	290	Chain	ID=PRO_0000214051;Note=Pirin
PIR	O00625	188	203	1	290	Chain	ID=PRO_0000214051;Note=Pirin
PIR	O00625	63	91	1	290	Chain	ID=PRO_0000214051;Note=Pirin
PIR	O00625	63	91	52	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	52	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GUL
PIR	O00625	63	91	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GUL
PIR	O00625	63	91	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	90	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	63	91	90	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	188	203	191	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	188	203	191	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	188	203	201	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PIR	O00625	188	203	201	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EWE
PLAA	Q9Y263	552	607	1	795	Chain	ID=PRO_0000051130;Note=Phospholipase A-2-activating protein
PLAA	Q9Y263	518	552	1	795	Chain	ID=PRO_0000051130;Note=Phospholipase A-2-activating protein
PLAA	Q9Y263	495	518	1	795	Chain	ID=PRO_0000051130;Note=Phospholipase A-2-activating protein
PLAA	Q9Y263	472	495	1	795	Chain	ID=PRO_0000051130;Note=Phospholipase A-2-activating protein
PLAA	Q9Y263	552	607	533	794	Domain	Note=PUL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00729
PLAA	Q9Y263	518	552	533	794	Domain	Note=PUL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00729
PLAA	Q9Y263	552	607	546	588	Repeat	Note=ARM 1
PLAA	Q9Y263	518	552	546	588	Repeat	Note=ARM 1
PLAA	Q9Y263	552	607	589	620	Repeat	Note=ARM 2
PLAA	Q9Y263	518	552	529	529	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PLAA	Q9Y263	518	552	520	520	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLAA	Q9Y263	518	552	531	531	Sequence conflict	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLAA	Q9Y263	518	552	541	541	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLAA	Q9Y263	552	607	548	559	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EBB
PLAA	Q9Y263	518	552	548	559	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EBB
PLAA	Q9Y263	552	607	564	566	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EBB
PLAA	Q9Y263	552	607	571	584	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EBB
PLAA	Q9Y263	552	607	593	603	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EBB
PLAA	Q9Y263	552	607	607	609	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EBB
PLIN3	O60664	278	320	2	434	Chain	ID=PRO_0000099890;Note=Perilipin-3
PLLP	Q9Y342	103	144	1	182	Chain	ID=PRO_0000156813;Note=Plasmolipin
PLLP	Q9Y342	103	144	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLLP	Q9Y342	103	144	121	141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLLP	Q9Y342	103	144	142	162	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLLP	Q9Y342	103	144	32	166	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
PLK1	P53350	397	423	2	603	Chain	ID=PRO_0000086556;Note=Serine/threonine-protein kinase PLK1
PLK1	P53350	397	423	417	480	Domain	Note=POLO box 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00154
PLK1	P53350	397	423	414	414	Mutagenesis	Note=Abolishes interaction with CDC25C and reduces centrosomal localization. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17307877;Dbxref=PMID:17307877
PLK1	P53350	397	423	414	414	Mutagenesis	Note=No effect on centrosomal localization%2C nor on S-phase progression%3B when asscociated with A-427. Loss of centrosomal localization and of S-phase progression%3B when associated with A- 415 and A-427. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24018379;Dbxref=PMID:24018379
PLK1	P53350	397	423	415	415	Mutagenesis	Note=Loss of centrosomal localization and of S-phase progression%3B when associated with A- 414 and A-427. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24018379;Dbxref=PMID:24018379
PLK1	P53350	397	423	397	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X9R
PLK1	P53350	397	423	403	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X9R
PLK1	P53350	397	423	411	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X9R
PLK1	P53350	397	423	418	421	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X9R
PLK1	P53350	397	423	422	427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X9R
PNPLA1	Q8N8W4	258	461	1	532	Chain	ID=PRO_0000292019;Note=Patatin-like phospholipase domain-containing protein 1
PNPLA1	Q8N8W4	258	461	326	451	Compositional bias	Note=Pro-rich
PNPLA1	Q8N8W4	258	461	423	423	Natural variant	ID=VAR_032929;Note=P->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12199580,PMID:14702039,PMID:15489334
PLA2G6	O60733	395	449	1	806	Chain	ID=PRO_0000067037;Note=85/88 kDa calcium-independent phospholipase A2
PLA2G6	O60733	298	359	1	806	Chain	ID=PRO_0000067037;Note=85/88 kDa calcium-independent phospholipase A2
PLA2G6	O60733	70	141	1	806	Chain	ID=PRO_0000067037;Note=85/88 kDa calcium-independent phospholipase A2
PLA2G6	O60733	298	359	286	312	Repeat	Note=ANK 5
PLA2G6	O60733	298	359	316	345	Repeat	Note=ANK 6
PLA2G6	O60733	298	359	349	378	Repeat	Note=ANK 7
PLA2G6	O60733	70	141	71	142	Alternative sequence	ID=VSP_000277;Note=In isoform Ankyrin-iPLA2-2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9417066;Dbxref=PMID:9417066
PLA2G6	O60733	395	449	396	450	Alternative sequence	ID=VSP_000278;Note=In isoform SH-iPLA2. LVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLE->Q;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10092647,ECO:0000303|PubMed:15489334;Dbxref=PMID:10092647,PMID:15489334
PLA2G6	O60733	70	141	70	70	Natural variant	ID=VAR_018963;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs11570607
PLA2G6	O60733	298	359	310	310	Natural variant	ID=VAR_029371;Note=In NBIA2A. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16783378;Dbxref=dbSNP:rs121908682,PMID:16783378
PLA2G6	O60733	298	359	343	343	Natural variant	ID=VAR_018965;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs11570680
PTPN14	Q15678	969	1012	1	1187	Chain	ID=PRO_0000219437;Note=Tyrosine-protein phosphatase non-receptor type 14
PTPN14	Q15678	848	896	1	1187	Chain	ID=PRO_0000219437;Note=Tyrosine-protein phosphatase non-receptor type 14
PTPN14	Q15678	969	1012	909	1180	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN14	Q15678	848	896	896	903	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN14	Q15678	969	1012	964	972	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN14	Q15678	969	1012	975	982	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN14	Q15678	969	1012	987	989	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN14	Q15678	969	1012	990	999	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN14	Q15678	969	1012	1004	1007	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN14	Q15678	969	1012	1011	1013	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BZL
PTPN18	Q99952	93	125	1	460	Chain	ID=PRO_0000094773;Note=Tyrosine-protein phosphatase non-receptor type 18
PTPN18	Q99952	125	138	1	460	Chain	ID=PRO_0000094773;Note=Tyrosine-protein phosphatase non-receptor type 18
PTPN18	Q99952	252	278	1	460	Chain	ID=PRO_0000094773;Note=Tyrosine-protein phosphatase non-receptor type 18
PTPN18	Q99952	413	438	1	460	Chain	ID=PRO_0000094773;Note=Tyrosine-protein phosphatase non-receptor type 18
PTPN18	Q99952	93	125	26	291	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN18	Q99952	125	138	26	291	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN18	Q99952	252	278	26	291	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN18	Q99952	252	278	276	276	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTPN18	Q99952	413	438	426	426	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61152
PTPN18	Q99952	93	125	32	138	Alternative sequence	ID=VSP_043073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTPN18	Q99952	125	138	32	138	Alternative sequence	ID=VSP_043073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTPN18	Q99952	93	125	85	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	93	125	97	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	93	125	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	93	125	112	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	125	138	126	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	125	138	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	252	278	260	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN18	Q99952	252	278	278	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OC3
PTPN23	Q9H3S7	28	53	1	1636	Chain	ID=PRO_0000094777;Note=Tyrosine-protein phosphatase non-receptor type 23
PTPN23	Q9H3S7	253	269	1	1636	Chain	ID=PRO_0000094777;Note=Tyrosine-protein phosphatase non-receptor type 23
PTPN23	Q9H3S7	269	288	1	1636	Chain	ID=PRO_0000094777;Note=Tyrosine-protein phosphatase non-receptor type 23
PTPN23	Q9H3S7	373	394	1	1636	Chain	ID=PRO_0000094777;Note=Tyrosine-protein phosphatase non-receptor type 23
PTPN23	Q9H3S7	1358	1392	1	1636	Chain	ID=PRO_0000094777;Note=Tyrosine-protein phosphatase non-receptor type 23
PTPN23	Q9H3S7	28	53	8	394	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
PTPN23	Q9H3S7	253	269	8	394	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
PTPN23	Q9H3S7	269	288	8	394	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
PTPN23	Q9H3S7	373	394	8	394	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
PTPN23	Q9H3S7	253	269	250	283	Repeat	Note=TPR 1
PTPN23	Q9H3S7	269	288	250	283	Repeat	Note=TPR 1
PTPN23	Q9H3S7	373	394	374	407	Repeat	Note=TPR 2
PTPN23	Q9H3S7	1358	1392	1192	1452	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN23	Q9H3S7	1358	1392	1392	1392	Active site	Note=Phosphocysteine intermediate;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160,ECO:0000255|PROSITE-ProRule:PRU10044
PTPN23	Q9H3S7	28	53	22	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	28	53	38	41	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	28	53	42	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	253	269	232	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	253	269	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	269	288	266	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	269	288	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MK2
PTPN23	Q9H3S7	373	394	373	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LM2
PTPN2	P17706	165	235	1	415	Chain	ID=PRO_0000094752;Note=Tyrosine-protein phosphatase non-receptor type 2
PTPN2	P17706	120	165	1	415	Chain	ID=PRO_0000094752;Note=Tyrosine-protein phosphatase non-receptor type 2
PTPN2	P17706	87	120	1	415	Chain	ID=PRO_0000094752;Note=Tyrosine-protein phosphatase non-receptor type 2
PTPN2	P17706	165	235	5	275	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN2	P17706	120	165	5	275	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN2	P17706	87	120	5	275	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN2	P17706	165	235	216	222	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTPN2	P17706	165	235	216	216	Active site	Note=Phosphocysteine intermediate;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160,ECO:0000255|PROSITE-ProRule:PRU10044
PTPN2	P17706	165	235	182	182	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTPN2	P17706	165	235	216	216	Modified residue	Note=S-nitrosocysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18031
PTPN2	P17706	165	235	165	165	Alternative sequence	ID=VSP_054821;Note=In isoform 4. N->NYIENLWITLYLKLLMLDVKRSLK;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPN2	P17706	120	165	165	165	Alternative sequence	ID=VSP_054821;Note=In isoform 4. N->NYIENLWITLYLKLLMLDVKRSLK;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPN2	P17706	165	235	182	182	Mutagenesis	Note=Substrate-trapping mutant%3B catalytically inactive it forms a stable complex with physiological substrates including INSR and EGFR. Accumulates in the cytoplasm upon stimulation by insulin or EGF%3B isoform 2. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12612081,ECO:0000269|PubMed:9488479;Dbxref=PMID:12612081,PMID:9488479
PTPN2	P17706	165	235	222	222	Mutagenesis	Note=Impairs phosphatase activity. R->M
PTPN2	P17706	87	120	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	87	120	91	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	87	120	94	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	87	120	108	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	120	165	129	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	120	165	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	120	165	137	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	120	165	141	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	120	165	152	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	120	165	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	169	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	182	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	190	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	202	205	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	212	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN2	P17706	165	235	222	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8K
PTPN6	P29350	3	43	1	595	Chain	ID=PRO_0000094758;Note=Tyrosine-protein phosphatase non-receptor type 6
PTPN6	P29350	44	108	1	595	Chain	ID=PRO_0000094758;Note=Tyrosine-protein phosphatase non-receptor type 6
PTPN6	P29350	172	211	1	595	Chain	ID=PRO_0000094758;Note=Tyrosine-protein phosphatase non-receptor type 6
PTPN6	P29350	3	43	4	100	Domain	Note=SH2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PTPN6	P29350	44	108	4	100	Domain	Note=SH2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PTPN6	P29350	172	211	110	213	Domain	Note=SH2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PTPN6	P29350	3	43	10	10	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P81718
PTPN6	P29350	44	108	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29351
PTPN6	P29350	44	108	64	64	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PTPN6	P29350	3	43	1	39	Alternative sequence	ID=VSP_005129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1652101;Dbxref=PMID:1652101
PTPN6	P29350	3	43	1	3	Alternative sequence	ID=VSP_007775;Note=In isoform 2. MVR->MLSRG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPN6	P29350	3	43	40	44	Alternative sequence	ID=VSP_005130;Note=In isoform 3. SLSVR->MLSRG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1652101;Dbxref=PMID:1652101
PTPN6	P29350	44	108	40	44	Alternative sequence	ID=VSP_005130;Note=In isoform 3. SLSVR->MLSRG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1652101;Dbxref=PMID:1652101
PTPN6	P29350	3	43	6	6	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPN6	P29350	44	108	86	86	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPN6	P29350	44	108	86	86	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPN6	P29350	3	43	11	21	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	3	43	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	3	43	33	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	33	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	48	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	57	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	61	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	72	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	89	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	44	108	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	172	211	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PS5
PTPN6	P29350	172	211	175	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	172	211	184	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	172	211	187	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	172	211	199	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RMX
PTPN6	P29350	172	211	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3O
PTPN6	P29350	172	211	205	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RMX
PTPRZ1	P23471	41	101	25	2315	Chain	ID=PRO_0000025468;Note=Receptor-type tyrosine-protein phosphatase zeta
PTPRZ1	P23471	1789	1834	25	2315	Chain	ID=PRO_0000025468;Note=Receptor-type tyrosine-protein phosphatase zeta
PTPRZ1	P23471	41	101	25	1636	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRZ1	P23471	1789	1834	1663	2315	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRZ1	P23471	41	101	36	300	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
PTPRZ1	P23471	1789	1834	1717	1992	Domain	Note=Tyrosine-protein phosphatase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRZ1	P23471	41	101	56	240	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20133774;Dbxref=PMID:20133774
PTPRZ1	P23471	41	101	40	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	46	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	49	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	54	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	58	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	71	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	41	101	94	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXF
PTPRZ1	P23471	1789	1834	1781	1790	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AWX
PTPRZ1	P23471	1789	1834	1793	1800	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AWX
PTPRZ1	P23471	1789	1834	1805	1807	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AWX
PTPRZ1	P23471	1789	1834	1808	1817	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AWX
PTPRZ1	P23471	1789	1834	1822	1825	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AWX
PTPRZ1	P23471	1789	1834	1829	1831	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AWX
PTPRE	P23469	241	281	20	700	Chain	ID=PRO_0000025439;Note=Receptor-type tyrosine-protein phosphatase epsilon
PTPRE	P23469	533	575	20	700	Chain	ID=PRO_0000025439;Note=Receptor-type tyrosine-protein phosphatase epsilon
PTPRE	P23469	241	281	70	700	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRE	P23469	533	575	70	700	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRE	P23469	241	281	135	394	Domain	Note=Tyrosine-protein phosphatase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRE	P23469	533	575	426	689	Domain	Note=Tyrosine-protein phosphatase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRE	P23469	241	281	250	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJD
PTPRE	P23469	241	281	259	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJD
PTPRE	P23469	241	281	270	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJD
PTPRE	P23469	533	575	542	548	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJD
PTPRE	P23469	533	575	551	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJD
PTPRE	P23469	533	575	562	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJD
RAB2B	Q8WUD1	158	181	1	216	Chain	ID=PRO_0000121071;Note=Ras-related protein Rab-2B
RAB2B	Q8WUD1	158	181	168	168	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB2B	Q8WUD1	158	181	156	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A5J
PEX14	O75381	12	28	2	377	Chain	ID=PRO_0000058325;Note=Peroxisomal membrane protein PEX14
PEX14	O75381	56	99	2	377	Chain	ID=PRO_0000058325;Note=Peroxisomal membrane protein PEX14
PEX14	O75381	56	99	58	100	Alternative sequence	ID=VSP_037021;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PEX14	O75381	56	99	56	56	Mutagenesis	Note=Reduced interaction with PEX19%2C minor effect on interaction with PEX5. K->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19197237;Dbxref=PMID:19197237
PEX14	O75381	12	28	19	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXU
PEX14	O75381	12	28	26	36	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W84
PEX14	O75381	56	99	60	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W84
RAB4A	P20338	10	37	1	218	Chain	ID=PRO_0000121093;Note=Ras-related protein Rab-4A
RAB4A	P20338	76	96	1	218	Chain	ID=PRO_0000121093;Note=Ras-related protein Rab-4A
RAB4A	P20338	10	37	20	28	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16034420;Dbxref=PMID:16034420
RAB4A	P20338	10	37	11	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BME
RAB4A	P20338	10	37	26	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BME
RAB4A	P20338	76	96	76	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BME
RAB4A	P20338	76	96	87	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BME
RAB4B	P61018	71	91	2	213	Chain	ID=PRO_0000121099;Note=Ras-related protein Rab-4B
RAB4B	P61018	71	91	2	213	Chain	ID=PRO_0000121099;Note=Ras-related protein Rab-4B
RAB4B	P61018	71	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O52
RAB4B	P61018	71	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O52
RAB4B	P61018	71	91	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O52
RAB4B	P61018	71	91	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O52
PEX7	O00628	211	249	1	323	Chain	ID=PRO_0000051116;Note=Peroxisomal targeting signal 2 receptor
PEX7	O00628	211	249	196	227	Repeat	Note=WD 4
PEX7	O00628	211	249	240	271	Repeat	Note=WD 5
PEX7	O00628	211	249	217	217	Natural variant	ID=VAR_007725;Note=In RCDP1%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9090381;Dbxref=dbSNP:rs121909152,PMID:9090381
PEX7	O00628	211	249	218	218	Natural variant	ID=VAR_007726;Note=In RCDP1. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9090381;Dbxref=dbSNP:rs121909151,PMID:9090381
RAB7A	P51149	60	133	2	207	Chain	ID=PRO_0000121121;Note=Ras-related protein Rab-7a
RAB7A	P51149	133	176	2	207	Chain	ID=PRO_0000121121;Note=Ras-related protein Rab-7a
RAB7A	P51149	60	133	63	67	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15933719,ECO:0000269|PubMed:20028791;Dbxref=PMID:15933719,PMID:20028791
RAB7A	P51149	60	133	125	128	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15933719,ECO:0000269|PubMed:20028791;Dbxref=PMID:15933719,PMID:20028791
RAB7A	P51149	133	176	156	157	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15933719,ECO:0000269|PubMed:20028791;Dbxref=PMID:15933719,PMID:20028791
RAB7A	P51149	60	133	72	72	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
RAB7A	P51149	60	133	129	129	Natural variant	ID=VAR_018722;Note=In CMT2B%3B increases GTP hydrolysis%3B decreases affinity for GTP and GDP%3B does not affect interaction with NTRK1%3B results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling. L->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12545426,ECO:0000269|PubMed:20028791,ECO:0000269|PubMed:21151572;Dbxref=dbSNP:rs121909078,PMID:12545426,PMID:20028791,PMID:21151572
RAB7A	P51149	133	176	157	157	Natural variant	ID=VAR_037887;Note=In CMT2B%3B does not affect interaction with NTRK1%3B results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling. K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17060578,ECO:0000269|PubMed:21151572;Dbxref=dbSNP:rs121909081,PMID:17060578,PMID:21151572
RAB7A	P51149	133	176	161	161	Natural variant	ID=VAR_037888;Note=In CMT2B%3B does not affect interaction with NTRK1%3B results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling. N->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15455439,ECO:0000269|PubMed:21151572;Dbxref=dbSNP:rs121909080,PMID:15455439,PMID:21151572
RAB7A	P51149	133	176	162	162	Natural variant	ID=VAR_018723;Note=In CMT2B%3B increases GTP hydrolysis%3B decreases affinity for GTP and GDP%3B does not affect interaction with NTRK1%3B results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12545426,ECO:0000269|PubMed:20028791,ECO:0000269|PubMed:21151572;Dbxref=dbSNP:rs121909079,PMID:12545426,PMID:20028791,PMID:21151572
RAB7A	P51149	60	133	67	67	Mutagenesis	Note=Does not abolish localization on late endosomes%2C lysosomes and phagosomes and does not reduce phagosomal fusions. No loss of interaction with CLN5. Q->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12944476,ECO:0000269|PubMed:22431521;Dbxref=PMID:12944476,PMID:22431521
RAB7A	P51149	60	133	108	108	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB7A	P51149	60	133	127	127	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB7A	P51149	60	133	56	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	60	133	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	60	133	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	60	133	93	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	60	133	99	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	60	133	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	60	133	120	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	133	176	136	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	133	176	151	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	133	176	156	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
RAB7A	P51149	133	176	162	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T91
PFKL	P17858	53	79	2	780	Chain	ID=PRO_0000112021;Note=ATP-dependent 6-phosphofructokinase%2C liver type
PFKL	P17858	550	605	2	780	Chain	ID=PRO_0000112021;Note=ATP-dependent 6-phosphofructokinase%2C liver type
PFKL	P17858	53	79	2	390	Region	Note=N-terminal catalytic PFK domain 1
PFKL	P17858	550	605	401	780	Region	Note=C-terminal regulatory PFK domain 2
PFKL	P17858	550	605	572	574	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKL	P17858	550	605	565	565	Binding site	Note=Allosteric activator fructose 2%2C6-bisphosphate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
CWH43	Q9H720	267	353	1	699	Chain	ID=PRO_0000320615;Note=PGAP2-interacting protein
CWH43	Q9H720	503	552	1	699	Chain	ID=PRO_0000320615;Note=PGAP2-interacting protein
CWH43	Q9H720	267	353	273	293	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CWH43	Q9H720	267	353	316	336	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CWH43	Q9H720	267	353	349	369	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	144	165	21	320	Chain	ID=PRO_0000339356;Note=Post-GPI attachment to proteins factor 3
PGAP3	Q96FM1	93	144	21	320	Chain	ID=PRO_0000339356;Note=Post-GPI attachment to proteins factor 3
PGAP3	Q96FM1	93	144	21	98	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	93	144	99	119	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	93	144	120	135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	144	165	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	93	144	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	144	165	157	169	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PGAP3	Q96FM1	144	165	94	144	Alternative sequence	ID=VSP_034158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
PGAP3	Q96FM1	93	144	94	144	Alternative sequence	ID=VSP_034158;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
PGAP3	Q96FM1	144	165	145	165	Alternative sequence	ID=VSP_057229;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PGAP3	Q96FM1	93	144	105	105	Natural variant	ID=VAR_071156;Note=In HPMRS4%3B results in partial functional impairment%3B the mutant does not localize to the Golgi apparatus but is retained in the endoplasmic reticulum. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24439110;Dbxref=dbSNP:rs371549948,PMID:24439110
PGAP3	Q96FM1	144	165	153	153	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDGFRA	P16234	16	122	1	23	Signal peptide	.
PDGFRA	P16234	16	122	24	1089	Chain	ID=PRO_0000016760;Note=Platelet-derived growth factor receptor alpha
PDGFRA	P16234	16	122	24	528	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRA	P16234	16	122	24	113	Domain	Note=Ig-like C2-type 1
PDGFRA	P16234	16	122	117	201	Domain	Note=Ig-like C2-type 2
PDGFRA	P16234	16	122	42	42	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRA	P16234	16	122	76	76	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRA	P16234	16	122	103	103	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRA	P16234	16	122	49	100	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PDGFRA	P16234	16	122	79	79	Natural variant	ID=VAR_042032;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36035373,PMID:17344846
RAD18	Q9NS91	441	461	1	495	Chain	ID=PRO_0000056149;Note=E3 ubiquitin-protein ligase RAD18
RAD18	Q9NS91	342	389	1	495	Chain	ID=PRO_0000056149;Note=E3 ubiquitin-protein ligase RAD18
RAD18	Q9NS91	342	389	376	376	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
RAD18	Q9NS91	441	461	442	442	Mutagenesis	Note=Does not interact with SLF1 and is defective in restoring cell survival after DNA damage%3B when associated with A-444. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22036607,ECO:0000269|PubMed:25931565;Dbxref=PMID:22036607,PMID:25931565
RAD18	Q9NS91	441	461	444	444	Mutagenesis	Note=Does not interact with SLF1 and is defective in restoring cell survival after DNA damage%3B when associated with A-442. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22036607,ECO:0000269|PubMed:25931565;Dbxref=PMID:22036607,PMID:25931565
RAD18	Q9NS91	342	389	342	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBF
RAD18	Q9NS91	342	389	347	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YBF
RAD1	O60671	189	221	1	282	Chain	ID=PRO_0000225005;Note=Cell cycle checkpoint protein RAD1
RAD1	O60671	189	221	1	282	Chain	ID=PRO_0000225005;Note=Cell cycle checkpoint protein RAD1
RAD1	O60671	189	221	69	282	Alternative sequence	ID=VSP_017336;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9878245;Dbxref=PMID:9878245
RAD1	O60671	189	221	69	282	Alternative sequence	ID=VSP_017336;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9878245;Dbxref=PMID:9878245
RAD1	O60671	189	221	183	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	183	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	197	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	197	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	205	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGR
RAD1	O60671	189	221	205	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GGR
RAD1	O60671	189	221	208	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	208	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	219	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
RAD1	O60671	189	221	219	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A1J
PGK1	P00558	39	90	2	417	Chain	ID=PRO_0000145831;Note=Phosphoglycerate kinase 1
PGK1	P00558	174	213	2	417	Chain	ID=PRO_0000145831;Note=Phosphoglycerate kinase 1
PGK1	P00558	252	312	2	417	Chain	ID=PRO_0000145831;Note=Phosphoglycerate kinase 1
PGK1	P00558	39	90	63	66	Region	Note=Substrate binding
PGK1	P00558	39	90	39	39	Binding site	Note=Substrate
PGK1	P00558	39	90	48	48	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGK1	P00558	39	90	48	48	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09411
PGK1	P00558	39	90	75	75	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGK1	P00558	39	90	76	76	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09411
PGK1	P00558	39	90	86	86	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGK1	P00558	174	213	191	191	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09411
PGK1	P00558	174	213	196	196	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
PGK1	P00558	174	213	199	199	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGK1	P00558	174	213	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PGK1	P00558	252	312	267	267	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGK1	P00558	252	312	291	291	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PGK1	P00558	39	90	88	88	Natural variant	ID=VAR_006076;Note=In PGK1D%3B with congenital non-spherocytic anemia%3B variant Matsue. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2001457;Dbxref=dbSNP:rs137852531,PMID:2001457
PGK1	P00558	174	213	191	191	Natural variant	ID=VAR_006079;Note=In PGK1D%3B with chronic hemolytic anemia%3B variant Alabama. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8673469;Dbxref=PMID:8673469
PGK1	P00558	174	213	206	206	Natural variant	ID=VAR_006080;Note=In PGK1D%3B with chronic hemolytic anemia%3B variant Uppsala. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6933565;Dbxref=dbSNP:rs137852529,PMID:6933565
PGK1	P00558	252	312	252	252	Natural variant	ID=VAR_006081;Note=In PGK1D%3B with chronic hemolytic anemia%3B variant Antwerp. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8615693;Dbxref=PMID:8615693
PGK1	P00558	252	312	266	266	Natural variant	ID=VAR_006082;Note=In PGK1D%3B with chronic non-spherocytic hemolytic anemia%3B variant Tokyo. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6941312;Dbxref=dbSNP:rs431905501,PMID:6941312
PGK1	P00558	252	312	268	268	Natural variant	ID=VAR_006083;Note=In Munchen%3B 21%25 of activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7391028,ECO:0000269|PubMed:7440217;Dbxref=dbSNP:rs137852528,PMID:7391028,PMID:7440217
PGK1	P00558	252	312	285	285	Natural variant	ID=VAR_006084;Note=In PGK1D%3B with chronic hemolytic anemia%3B variant Herlev%3B 50%25 of activity. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9744480;Dbxref=dbSNP:rs137852535,PMID:9744480
PGK1	P00558	39	90	39	39	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PGK1	P00558	39	90	38	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	39	90	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	39	90	73	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	39	90	79	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	174	213	174	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	174	213	184	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	174	213	188	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	174	213	206	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	260	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	266	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	279	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	285	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	298	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	303	305	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PGK1	P00558	252	312	312	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WZB
PDGFRB	P09619	602	637	33	1106	Chain	ID=PRO_0000016757;Note=Platelet-derived growth factor receptor beta
PDGFRB	P09619	602	637	554	1106	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRB	P09619	602	637	600	962	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PDGFRB	P09619	602	637	606	614	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PDGFRB	P09619	602	637	634	634	Binding site	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDGFRB	P09619	602	637	337	1106	Alternative sequence	ID=VSP_056009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
PDGFRB	P09619	602	637	634	634	Mutagenesis	Note=Loss of kinase activity. Abolishes interaction with RASA1. No effect on phosphatidylinositol 3-kinase activity. K->A%2CR;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1314164,ECO:0000269|PubMed:1846866,ECO:0000269|PubMed:20494825;Dbxref=PMID:1314164,PMID:1846866,PMID:20494825
PGPEP1	Q9NXJ5	29	68	1	209	Chain	ID=PRO_0000184761;Note=Pyroglutamyl-peptidase 1
PGPEP1	Q9NXJ5	29	68	1	77	Alternative sequence	ID=VSP_056472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PGLYRP2	Q96PD5	20	377	1	21	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15340161,ECO:0000269|PubMed:7663175;Dbxref=PMID:15340161,PMID:7663175
PGLYRP2	Q96PD5	20	377	22	576	Chain	ID=PRO_0000023920;Note=N-acetylmuramoyl-L-alanine amidase
PGLYRP2	Q96PD5	20	377	239	239	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16054449;Dbxref=PMID:16054449
PGLYRP2	Q96PD5	20	377	274	274	Modified residue	Note=Deamidated asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16054449;Dbxref=PMID:16054449
PGLYRP2	Q96PD5	20	377	322	322	Modified residue	Note=Deamidated asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16054449;Dbxref=PMID:16054449
PGLYRP2	Q96PD5	20	377	77	77	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
PGLYRP2	Q96PD5	20	377	367	367	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
PGLYRP2	Q96PD5	20	377	46	46	Natural variant	ID=VAR_050498;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs3813135,PMID:12975309
PGLYRP2	Q96PD5	20	377	99	99	Natural variant	ID=VAR_050499;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs733731,PMID:12975309
PGLYRP2	Q96PD5	20	377	257	257	Natural variant	ID=VAR_050500;Note=T->N;Dbxref=dbSNP:rs28404490
PGLYRP2	Q96PD5	20	377	270	270	Natural variant	ID=VAR_050501;Note=M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs892145,PMID:12975309
PGLYRP2	Q96PD5	20	377	124	124	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAI14	Q9P0K7	255	284	1	980	Chain	ID=PRO_0000239630;Note=Ankycorbin
RAI14	Q9P0K7	883	933	1	980	Chain	ID=PRO_0000239630;Note=Ankycorbin
RAI14	Q9P0K7	255	284	1	980	Chain	ID=PRO_0000239630;Note=Ankycorbin
RAI14	Q9P0K7	883	933	1	980	Chain	ID=PRO_0000239630;Note=Ankycorbin
RAI14	Q9P0K7	255	284	1	980	Chain	ID=PRO_0000239630;Note=Ankycorbin
RAI14	Q9P0K7	883	933	1	980	Chain	ID=PRO_0000239630;Note=Ankycorbin
RAI14	Q9P0K7	883	933	425	947	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAI14	Q9P0K7	883	933	425	947	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAI14	Q9P0K7	883	933	425	947	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAI14	Q9P0K7	255	284	270	276	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16729964;Dbxref=PMID:16729964
RAI14	Q9P0K7	255	284	270	276	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16729964;Dbxref=PMID:16729964
RAI14	Q9P0K7	255	284	270	276	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16729964;Dbxref=PMID:16729964
RAI14	Q9P0K7	255	284	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RAI14	Q9P0K7	255	284	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RAI14	Q9P0K7	255	284	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RAI14	Q9P0K7	883	933	915	915	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EP71
RAI14	Q9P0K7	883	933	915	915	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EP71
RAI14	Q9P0K7	883	933	915	915	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EP71
RAI14	Q9P0K7	255	284	255	283	Alternative sequence	ID=VSP_045814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAI14	Q9P0K7	255	284	255	283	Alternative sequence	ID=VSP_045814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAI14	Q9P0K7	255	284	255	283	Alternative sequence	ID=VSP_045814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAI14	Q9P0K7	255	284	272	272	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAI14	Q9P0K7	255	284	272	272	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAI14	Q9P0K7	255	284	272	272	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAI14	Q9P0K7	255	284	272	272	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAI14	Q9P0K7	255	284	272	272	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAI14	Q9P0K7	255	284	272	272	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RANBP3	Q9H6Z4	231	271	2	567	Chain	ID=PRO_0000097165;Note=Ran-binding protein 3
RANBP3	Q9H6Z4	157	188	2	567	Chain	ID=PRO_0000097165;Note=Ran-binding protein 3
RANBP3	Q9H6Z4	135	157	2	567	Chain	ID=PRO_0000097165;Note=Ran-binding protein 3
RANBP3	Q9H6Z4	26	94	2	567	Chain	ID=PRO_0000097165;Note=Ran-binding protein 3
RANBP3	Q9H6Z4	26	94	76	81	Compositional bias	Note=Poly-Pro
RANBP3	Q9H6Z4	26	94	75	75	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RANBP3	Q9H6Z4	26	94	27	94	Alternative sequence	ID=VSP_011163;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9637251;Dbxref=PMID:14702039,PMID:15489334,PMID:9637251
RAP1A	P62834	108	156	1	181	Chain	ID=PRO_0000030199;Note=Ras-related protein Rap-1A
RAP1A	P62834	108	156	1	181	Chain	ID=PRO_0000030199;Note=Ras-related protein Rap-1A
RAP1A	P62834	108	156	116	119	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7791872,ECO:0000269|PubMed:8756332;Dbxref=PMID:7791872,PMID:8756332
RAP1A	P62834	108	156	116	119	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7791872,ECO:0000269|PubMed:8756332;Dbxref=PMID:7791872,PMID:8756332
RAP1A	P62834	108	156	111	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	111	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	121	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	121	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	128	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	128	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	138	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GUA
RAP1A	P62834	108	156	138	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GUA
RAP1A	P62834	108	156	142	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	142	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	148	150	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	148	150	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	154	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
RAP1A	P62834	108	156	154	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KVG
PHF11	Q9UIL8	212	256	1	331	Chain	ID=PRO_0000059301;Note=PHD finger protein 11
PHF11	Q9UIL8	256	280	1	331	Chain	ID=PRO_0000059301;Note=PHD finger protein 11
PHF12	Q96QT6	786	819	1	1004	Chain	ID=PRO_0000059302;Note=PHD finger protein 12
PHF12	Q96QT6	696	738	1	1004	Chain	ID=PRO_0000059302;Note=PHD finger protein 12
PHF12	Q96QT6	786	819	815	869	Domain	Note=FHA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00086
PHF12	Q96QT6	696	738	300	704	Region	Note=Interaction with SIN3A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11390640;Dbxref=PMID:11390640
PHF12	Q96QT6	696	738	697	704	Alternative sequence	ID=VSP_051769;Note=In isoform 2. DGKVSPGT->GECCSALG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11390640,ECO:0000303|PubMed:15489334;Dbxref=PMID:11390640,PMID:15489334
PHF12	Q96QT6	786	819	705	1004	Alternative sequence	ID=VSP_051770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11390640,ECO:0000303|PubMed:15489334;Dbxref=PMID:11390640,PMID:15489334
PHF12	Q96QT6	696	738	705	1004	Alternative sequence	ID=VSP_051770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11390640,ECO:0000303|PubMed:15489334;Dbxref=PMID:11390640,PMID:15489334
PHF12	Q96QT6	786	819	787	849	Alternative sequence	ID=VSP_051771;Note=In isoform 3 and isoform 5. VQRKEVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENT->GAHVHTCHHIIRSPLYVCEWSPCLHGESELPVSQTSLCAFHGLNKAPWFFSEESRNKMATTAF;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PHF14	O94880	439	485	1	888	Chain	ID=PRO_0000059306;Note=PHD finger protein 14
PHF14	O94880	485	534	1	888	Chain	ID=PRO_0000059306;Note=PHD finger protein 14
PHF14	O94880	660	692	1	888	Chain	ID=PRO_0000059306;Note=PHD finger protein 14
PHF14	O94880	827	844	1	888	Chain	ID=PRO_0000059306;Note=PHD finger protein 14
PHF14	O94880	439	485	439	499	Zinc finger	Note=PHD-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01146
PHF14	O94880	485	534	439	499	Zinc finger	Note=PHD-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01146
PHF14	O94880	485	534	530	530	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
PHF14	O94880	827	844	835	835	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHF19	Q5T6S3	435	466	1	580	Chain	ID=PRO_0000318570;Note=PHD finger protein 19
PHF19	Q5T6S3	237	259	1	580	Chain	ID=PRO_0000318570;Note=PHD finger protein 19
PHF19	Q5T6S3	237	259	195	249	Zinc finger	Note=PHD-type 2
PHF19	Q5T6S3	435	466	131	580	Alternative sequence	ID=VSP_031223;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHF19	Q5T6S3	237	259	131	580	Alternative sequence	ID=VSP_031223;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHF19	Q5T6S3	435	466	208	580	Alternative sequence	ID=VSP_031225;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHF19	Q5T6S3	237	259	208	580	Alternative sequence	ID=VSP_031225;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PHF2	O75151	413	443	1	1096	Chain	ID=PRO_0000059290;Note=Lysine-specific demethylase PHF2
PHF2	O75151	566	606	1	1096	Chain	ID=PRO_0000059290;Note=Lysine-specific demethylase PHF2
PHF2	O75151	875	907	1	1096	Chain	ID=PRO_0000059290;Note=Lysine-specific demethylase PHF2
PHF2	O75151	566	606	487	648	Compositional bias	Note=Lys-rich
PHF2	O75151	875	907	879	879	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0
PHF2	O75151	875	907	882	882	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
PHF2	O75151	875	907	899	899	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
PHF2	O75151	875	907	899	899	Mutagenesis	Note=Abolishes phosphorylation by PKA and activation of demethylase activity%3B when associated with A-757%3B A-954 and A-1056. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585
PHF2	O75151	875	907	888	888	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PHF2	O75151	413	443	412	414	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PU8
PHF2	O75151	413	443	415	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PU8
PHF2	O75151	413	443	419	421	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUA
PHF2	O75151	413	443	428	443	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PUA
PHF3	Q92576	81	135	1	2039	Chain	ID=PRO_0000059292;Note=PHD finger protein 3
PHF3	Q92576	81	135	1	2039	Chain	ID=PRO_0000059292;Note=PHD finger protein 3
PHF3	Q92576	81	135	97	97	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHF3	Q92576	81	135	97	97	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHF3	Q92576	81	135	125	125	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHF3	Q92576	81	135	125	125	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PHF3	Q92576	81	135	1	88	Alternative sequence	ID=VSP_026434;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PHF3	Q92576	81	135	1	88	Alternative sequence	ID=VSP_026434;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PHF7	Q9BWX1	227	265	1	381	Chain	ID=PRO_0000055996;Note=PHD finger protein 7
PHF7	Q9BWX1	227	265	228	266	Alternative sequence	ID=VSP_046255;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PELI2	Q9HAT8	69	103	1	420	Chain	ID=PRO_0000194174;Note=E3 ubiquitin-protein ligase pellino homolog 2
PELI2	Q9HAT8	69	103	15	202	Domain	Note=FHA%3B atypical
PELI2	Q9HAT8	69	103	76	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EGA
PELI2	Q9HAT8	69	103	84	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EGA
PELI2	Q9HAT8	69	103	99	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EGA
RAB1A	P62820	96	140	2	205	Chain	ID=PRO_0000121056;Note=Ras-related protein Rab-1A
RAB1A	P62820	64	96	2	205	Chain	ID=PRO_0000121056;Note=Ras-related protein Rab-1A
RAB1A	P62820	32	64	2	205	Chain	ID=PRO_0000121056;Note=Ras-related protein Rab-1A
RAB1A	P62820	32	64	36	43	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2FOL,ECO:0000244|PDB:3SFV,ECO:0000244|PDB:3TKL,ECO:0000244|PDB:4FMC,ECO:0000244|PDB:4FME,ECO:0000244|PDB:4IRU,ECO:0000244|PDB:4JVS,ECO:0000269|PubMed:22416225,ECO:0000269|PubMed:22939626,ECO:0000269|PubMed:23588383,ECO:0000269|PubMed:23821544;Dbxref=PMID:22416225,PMID:22939626,PMID:23588383,PMID:23821544
RAB1A	P62820	64	96	66	70	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3TKL,ECO:0000269|PubMed:22416225;Dbxref=PMID:22416225
RAB1A	P62820	96	140	124	127	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2FOL,ECO:0000244|PDB:3SFV,ECO:0000244|PDB:3TKL,ECO:0000244|PDB:4FMB,ECO:0000244|PDB:4FMC,ECO:0000244|PDB:4FMD,ECO:0000244|PDB:4FME,ECO:0000244|PDB:4IRU,ECO:0000244|PDB:4JVS,ECO:0000269|PubMed:22416225,ECO:0000269|PubMed:22939626,ECO:0000269|PubMed:23588383,ECO:0000269|PubMed:23821544;Dbxref=PMID:22416225,PMID:22939626,PMID:23588383,PMID:23821544
RAB1A	P62820	32	64	40	48	Motif	Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250
RAB1A	P62820	64	96	79	79	Modified residue	Note=O-(2-cholinephosphoryl)serine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21822290,ECO:0000269|PubMed:22158903;Dbxref=PMID:21822290,PMID:22158903
RAB1A	P62820	96	140	33	96	Alternative sequence	ID=VSP_005525;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB1A	P62820	64	96	33	96	Alternative sequence	ID=VSP_005525;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB1A	P62820	32	64	33	96	Alternative sequence	ID=VSP_005525;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB1A	P62820	96	140	65	140	Alternative sequence	ID=VSP_005526;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.6;Dbxref=PMID:11230166
RAB1A	P62820	64	96	65	140	Alternative sequence	ID=VSP_005526;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.6;Dbxref=PMID:11230166
RAB1A	P62820	96	140	124	124	Mutagenesis	Note=Dominant negative mutant. Strongly reduces the levels of CASR present at the cell-surface. N->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20861236;Dbxref=PMID:20861236
RAB1A	P62820	32	64	30	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L0I
RAB1A	P62820	32	64	39	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	32	64	47	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	64	96	58	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	32	64	58	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	64	96	70	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	64	96	78	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	64	96	81	83	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SFV
RAB1A	P62820	64	96	85	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	96	140	96	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	64	96	96	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	96	140	117	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB1A	P62820	96	140	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SFV
RAB1A	P62820	96	140	136	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WWX
RAB8A	P61006	108	138	1	204	Chain	ID=PRO_0000121130;Note=Ras-related protein Rab-8A
RAB8A	P61006	160	177	1	204	Chain	ID=PRO_0000121130;Note=Ras-related protein Rab-8A
RAB8A	P61006	108	138	121	124	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5SZI,ECO:0000269|PubMed:27552051;Dbxref=PMID:27552051
RAB8A	P61006	160	177	161	205	Alternative sequence	ID=VSP_056399;Note=In isoform 2. AFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRSSFFRCV->RYQSKNGQKIGRQQPPGEQPGSQNHTGPAEEEQLFPMCSSVRNTA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAB8A	P61006	160	177	177	183	Sequence conflict	Note=LEGNSPQ->WKATAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAB8A	P61006	108	138	99	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LHW
RAB8A	P61006	108	138	115	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LHW
RAB8A	P61006	108	138	122	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LHX
RAB8A	P61006	108	138	126	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LHW
RAB8A	P61006	108	138	133	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LHW
RAB8A	P61006	160	177	158	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LHW
CRABP1	P29762	83	121	1	137	Chain	ID=PRO_0000067406;Note=Cellular retinoic acid-binding protein 1
CRABP1	P29762	83	121	112	112	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRABP2	P29373	83	122	1	138	Chain	ID=PRO_0000067415;Note=Cellular retinoic acid-binding protein 2
CRABP2	P29373	83	122	1	138	Chain	ID=PRO_0000067415;Note=Cellular retinoic acid-binding protein 2
CRABP2	P29373	83	122	102	102	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21998312;Dbxref=PMID:21998312
CRABP2	P29373	83	122	102	102	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21998312;Dbxref=PMID:21998312
CRABP2	P29373	83	122	81	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	81	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	93	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	93	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	108	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	108	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M7M
CRABP2	P29373	83	122	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M7M
CRABP2	P29373	83	122	120	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
CRABP2	P29373	83	122	120	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G7B
PFKP	Q01813	207	221	1	784	Chain	ID=PRO_0000112024;Note=ATP-dependent 6-phosphofructokinase%2C platelet type
PFKP	Q01813	321	363	1	784	Chain	ID=PRO_0000112024;Note=ATP-dependent 6-phosphofructokinase%2C platelet type
PFKP	Q01813	510	561	1	784	Chain	ID=PRO_0000112024;Note=ATP-dependent 6-phosphofructokinase%2C platelet type
PFKP	Q01813	207	221	1	399	Region	Note=N-terminal catalytic PFK domain 1
PFKP	Q01813	321	363	1	399	Region	Note=N-terminal catalytic PFK domain 1
PFKP	Q01813	207	221	217	219	Region	Note=Substrate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKP	Q01813	510	561	412	784	Region	Note=C-terminal regulatory PFK domain 2
PFKP	Q01813	510	561	538	542	Region	Note=Allosteric activator fructose 2%2C6-bisphosphate binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKP	Q01813	207	221	210	210	Binding site	Note=Substrate%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03184
PFKP	Q01813	510	561	540	540	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
PFKP	Q01813	207	221	187	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	207	221	210	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	321	363	316	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	321	363	338	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	321	363	343	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	321	363	351	356	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	321	363	357	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	510	561	509	520	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	510	561	521	524	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	510	561	526	528	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	510	561	532	540	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
PFKP	Q01813	510	561	552	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XZ2
RAC3	P60763	75	96	1	189	Chain	ID=PRO_0000198889;Note=Ras-related C3 botulinum toxin substrate 3
RAC3	P60763	75	96	76	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QME
RAC3	P60763	75	96	87	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QME
PDGFRL	Q15198	168	266	22	375	Chain	ID=PRO_0000233090;Note=Platelet-derived growth factor receptor-like protein
PDGFRL	Q15198	168	266	22	375	Chain	ID=PRO_0000233090;Note=Platelet-derived growth factor receptor-like protein
PDGFRL	Q15198	168	266	219	219	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRL	Q15198	168	266	219	219	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PDGFRL	Q15198	168	266	227	227	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PDGFRL	Q15198	168	266	227	227	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PGM5	Q15124	141	190	1	567	Chain	ID=PRO_0000147787;Note=Phosphoglucomutase-like protein 5
PGM5	Q15124	493	538	1	567	Chain	ID=PRO_0000147787;Note=Phosphoglucomutase-like protein 5
PGM5	Q15124	493	538	510	513	Compositional bias	Note=Poly-Ser
PGM5	Q15124	493	538	520	520	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00949
PGM5	Q15124	493	538	388	567	Alternative sequence	ID=VSP_030015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RASIP1	Q5U651	393	611	1	963	Chain	ID=PRO_0000097163;Note=Ras-interacting protein 1
RASIP1	Q5U651	393	611	600	897	Domain	Note=Dilute;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00503
RASIP1	Q5U651	393	611	419	419	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RASIP1	Q5U651	393	611	601	601	Natural variant	ID=VAR_051302;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15031288;Dbxref=dbSNP:rs2287922,PMID:15031288
RASIP1	Q5U651	393	611	500	500	Sequence conflict	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RASIP1	Q5U651	393	611	511	517	Sequence conflict	Note=PPGPGWA->RQPWLG;Ontology_term=ECO:0000305;evidence=ECO:0000305
DCN	P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
DCN	P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
DCN	P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
DCN	P07585	179	217	163	186	Repeat	Note=LRR 5
DCN	P07585	179	217	163	186	Repeat	Note=LRR 5
DCN	P07585	179	217	163	186	Repeat	Note=LRR 5
DCN	P07585	179	217	187	212	Repeat	Note=LRR 6
DCN	P07585	179	217	187	212	Repeat	Note=LRR 6
DCN	P07585	179	217	187	212	Repeat	Note=LRR 6
DCN	P07585	179	217	213	233	Repeat	Note=LRR 7
DCN	P07585	179	217	213	233	Repeat	Note=LRR 7
DCN	P07585	179	217	213	233	Repeat	Note=LRR 7
DCN	P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
DCN	P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
DCN	P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
DCN	P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCN	P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
RALYL	Q86SE5	111	121	1	291	Chain	ID=PRO_0000299525;Note=RNA-binding Raly-like protein
RALYL	Q86SE5	122	137	1	291	Chain	ID=PRO_0000299525;Note=RNA-binding Raly-like protein
RALYL	Q86SE5	111	121	1	291	Chain	ID=PRO_0000299525;Note=RNA-binding Raly-like protein
RALYL	Q86SE5	122	137	1	291	Chain	ID=PRO_0000299525;Note=RNA-binding Raly-like protein
RALYL	Q86SE5	111	121	1	291	Chain	ID=PRO_0000299525;Note=RNA-binding Raly-like protein
RALYL	Q86SE5	122	137	1	291	Chain	ID=PRO_0000299525;Note=RNA-binding Raly-like protein
PHACTR3	Q96KR7	93	119	1	559	Chain	ID=PRO_0000126638;Note=Phosphatase and actin regulator 3
PHACTR3	Q96KR7	119	180	1	559	Chain	ID=PRO_0000126638;Note=Phosphatase and actin regulator 3
PHACTR3	Q96KR7	180	250	1	559	Chain	ID=PRO_0000126638;Note=Phosphatase and actin regulator 3
PHACTR3	Q96KR7	482	529	1	559	Chain	ID=PRO_0000126638;Note=Phosphatase and actin regulator 3
PHACTR3	Q96KR7	93	119	93	118	Repeat	Note=RPEL 1
PHACTR3	Q96KR7	482	529	477	502	Repeat	Note=RPEL 4
PHACTR3	Q96KR7	482	529	438	518	Region	Note=Required for PP1CA binding and inhibition of PP1 activity
PHACTR3	Q96KR7	482	529	450	486	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PHACTR3	Q96KR7	180	250	217	239	Compositional bias	Note=Pro-rich
PHACTR3	Q96KR7	180	250	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BYK5
PHACTR3	Q96KR7	180	250	236	236	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BYK5
PHACTR3	Q96KR7	180	250	181	250	Alternative sequence	ID=VSP_009092;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12925532;Dbxref=PMID:12925532
PHACTR3	Q96KR7	119	180	154	154	Natural variant	ID=VAR_021969;Note=P->L;Dbxref=dbSNP:rs2277759
PHACTR3	Q96KR7	93	119	118	118	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RASSF6	Q6ZTQ3	221	255	1	369	Chain	ID=PRO_0000240404;Note=Ras association domain-containing protein 6
RASSF6	Q6ZTQ3	221	255	218	306	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
RASSF6	Q6ZTQ3	221	255	222	255	Alternative sequence	ID=VSP_019372;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PCBD2	Q9H0N5	28	72	1	130	Chain	ID=PRO_0000063057;Note=Pterin-4-alpha-carbinolamine dehydratase 2
PCBD2	Q9H0N5	28	72	36	36	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PCBD2	Q9H0N5	28	72	37	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C45
PCBD2	Q9H0N5	28	72	56	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C45
PCBD2	Q9H0N5	28	72	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C45
PCBD2	Q9H0N5	28	72	70	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C45
PIK3R4	Q99570	1033	1087	2	1358	Chain	ID=PRO_0000086524;Note=Phosphoinositide 3-kinase regulatory subunit 4
PIK3R4	Q99570	528	602	2	1358	Chain	ID=PRO_0000086524;Note=Phosphoinositide 3-kinase regulatory subunit 4
PIK3R4	Q99570	528	602	572	610	Repeat	Note=HEAT 3
PIK3R4	Q99570	1033	1087	1040	1079	Repeat	Note=WD 2
PIK3R4	Q99570	1033	1087	1043	1043	Natural variant	ID=VAR_041003;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56160735,PMID:17344846
PIK3R4	Q99570	528	602	553	554	Sequence conflict	Note=KQ->FK;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIEZO1	Q92508	2220	2251	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	1592	1651	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	1387	1411	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	1323	1352	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	1065	1100	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	53	94	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	21	53	1	2521	Chain	ID=PRO_0000186817;Note=Piezo-type mechanosensitive ion channel component 1
PIEZO1	Q92508	21	53	5	25	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO1	Q92508	21	53	27	47	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO1	Q92508	53	94	64	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO1	Q92508	2220	2251	2198	2431	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E2JF22
PIEZO1	Q92508	1323	1352	1339	1368	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO1	Q92508	53	94	6	91	Compositional bias	Note=Leu-rich
PIEZO1	Q92508	21	53	6	91	Compositional bias	Note=Leu-rich
PIEZO1	Q92508	1387	1411	1391	1391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
PIEZO1	Q92508	1387	1411	1396	1396	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PIEZO1	Q92508	1592	1651	1636	1636	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PIEZO1	Q92508	1592	1651	1646	1646	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
PIEZO1	Q92508	2220	2251	2225	2225	Natural variant	ID=VAR_069832;Note=In DHS1%3B gives rise to mechanically activated currents that inactivate more slowly than wild-type currents. M->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22529292,ECO:0000269|PubMed:23487776,ECO:0000269|PubMed:23695678;Dbxref=dbSNP:rs587776987,PMID:22529292,PMID:23487776,PMID:23695678
PIEZO2	Q9H5I5	2386	2449	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	1973	2034	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	1520	1544	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	1193	1227	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	957	1016	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	400	413	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	21	53	1	2752	Chain	ID=PRO_0000186818;Note=Piezo-type mechanosensitive ion channel component 2
PIEZO2	Q9H5I5	21	53	5	25	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	21	53	27	47	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	957	1016	958	978	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	957	1016	985	1005	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	1193	1227	1217	1237	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	1973	2034	1967	1987	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	2386	2449	2406	2426	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	1520	1544	1458	1529	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	957	1016	1013	1013	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIEZO2	Q9H5I5	1973	2034	1	2043	Alternative sequence	ID=VSP_040471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	1520	1544	1	2043	Alternative sequence	ID=VSP_040471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	1193	1227	1	2043	Alternative sequence	ID=VSP_040471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	957	1016	1	2043	Alternative sequence	ID=VSP_040471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	400	413	1	2043	Alternative sequence	ID=VSP_040471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	21	53	1	2043	Alternative sequence	ID=VSP_040471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	2386	2449	2387	2449	Alternative sequence	ID=VSP_040472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIEZO2	Q9H5I5	957	1016	980	980	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIEZO2	Q9H5I5	957	1016	999	999	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGB	Q92521	139	174	1	554	Chain	ID=PRO_0000246251;Note=GPI mannosyltransferase 3
PIGB	Q92521	218	264	1	554	Chain	ID=PRO_0000246251;Note=GPI mannosyltransferase 3
PIGB	Q92521	139	174	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGB	Q92521	218	264	224	244	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGB	Q92521	218	264	255	275	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGB	Q92521	139	174	162	162	Natural variant	ID=VAR_027028;Note=M->T;Dbxref=dbSNP:rs2290344
PIGO	Q8TEQ8	313	373	1	1089	Chain	ID=PRO_0000058438;Note=GPI ethanolamine phosphate transferase 3
PIGO	Q8TEQ8	313	373	344	344	Natural variant	ID=VAR_079412;Note=In HPMRS2%3B decrease in mannose-ethanolamine phosphotransferase activity%3B decreased protein expression%3B unknown pathological significance. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28337824;Dbxref=dbSNP:rs779525065,PMID:28337824
PIGO	Q8TEQ8	313	373	370	370	Natural variant	ID=VAR_079413;Note=In HPMRS2%3B decrease in mannose-ethanolamine phosphotransferase activity%3B decreased protein expression. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28337824;Dbxref=dbSNP:rs1214104267,PMID:28337824
PIGO	Q8TEQ8	313	373	350	350	Sequence conflict	Note=G->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGO	Q8TEQ8	313	373	353	353	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PI4KA	P42356	2028	2057	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1892	1934	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1857	1892	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1647	1665	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1591	1647	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1429	1469	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1247	1300	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1121	1152	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1051	1081	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	575	606	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	335	357	1	2102	Chain	ID=PRO_0000088827;Note=Phosphatidylinositol 4-kinase alpha
PI4KA	P42356	1647	1665	1530	1718	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PI4KA	P42356	1591	1647	1530	1718	Domain	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878
PI4KA	P42356	2028	2057	1846	2079	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PI4KA	P42356	1892	1934	1846	2079	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PI4KA	P42356	1857	1892	1846	2079	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PI4KA	P42356	1429	1469	1436	1436	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:23186163,PMID:24275569
PI4KA	P42356	1247	1300	1	1248	Alternative sequence	ID=VSP_008805;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7961848;Dbxref=PMID:7961848
PI4KA	P42356	1121	1152	1	1248	Alternative sequence	ID=VSP_008805;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7961848;Dbxref=PMID:7961848
PI4KA	P42356	1051	1081	1	1248	Alternative sequence	ID=VSP_008805;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7961848;Dbxref=PMID:7961848
PI4KA	P42356	575	606	1	1248	Alternative sequence	ID=VSP_008805;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7961848;Dbxref=PMID:7961848
PI4KA	P42356	335	357	1	1248	Alternative sequence	ID=VSP_008805;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7961848;Dbxref=PMID:7961848
RAD51AP1	Q96B01	70	86	1	352	Chain	ID=PRO_0000097140;Note=RAD51-associated protein 1
RAD51AP1	Q96B01	257	307	1	352	Chain	ID=PRO_0000097140;Note=RAD51-associated protein 1
RAD51AP1	Q96B01	257	307	280	280	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
RAD51AP1	Q96B01	70	86	71	87	Alternative sequence	ID=VSP_051739;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9396801;Dbxref=PMID:14702039,PMID:15489334,PMID:9396801
RAD51AP1	Q96B01	257	307	258	307	Alternative sequence	ID=VSP_051740;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9396801;Dbxref=PMID:9396801
PEBP4	Q96S96	86	119	23	227	Chain	ID=PRO_0000023279;Note=Phosphatidylethanolamine-binding protein 4
PELP1	Q8IZL8	214	234	2	1130	Chain	ID=PRO_0000252135;Note=Proline-%2C glutamic acid- and leucine-rich protein 1
PGA3	P0DJD8	219	257	63	388	Chain	ID=PRO_0000026014;Note=Pepsin A-3
PGA3	P0DJD8	219	257	76	385	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
HSPG2	P98160	4272	4299	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	4177	4196	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	4136	4177	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	3923	3997	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	3890	3923	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	3064	3109	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	1900	1951	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	1671	1727	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	1542	1580	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	1343	1407	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	1219	1247	22	4391	Chain	ID=PRO_0000026696;Note=Basement membrane-specific heparan sulfate proteoglycan core protein
HSPG2	P98160	4272	4299	3687	4391	Chain	ID=PRO_0000391621;Note=Endorepellin
HSPG2	P98160	4177	4196	3687	4391	Chain	ID=PRO_0000391621;Note=Endorepellin
HSPG2	P98160	4136	4177	3687	4391	Chain	ID=PRO_0000391621;Note=Endorepellin
HSPG2	P98160	3923	3997	3687	4391	Chain	ID=PRO_0000391621;Note=Endorepellin
HSPG2	P98160	3890	3923	3687	4391	Chain	ID=PRO_0000391621;Note=Endorepellin
HSPG2	P98160	4272	4299	4197	4391	Chain	ID=PRO_0000391622;Note=LG3 peptide
HSPG2	P98160	1219	1247	1209	1265	Domain	Note=Laminin EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
HSPG2	P98160	1343	1407	1344	1529	Domain	Note=Laminin IV type A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00458
HSPG2	P98160	1542	1580	1530	1562	Domain	Note=Laminin EGF-like 9%3B second part;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
HSPG2	P98160	1542	1580	1563	1612	Domain	Note=Laminin EGF-like 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
HSPG2	P98160	1671	1727	1677	1771	Domain	Note=Ig-like C2-type 2
HSPG2	P98160	1900	1951	1866	1955	Domain	Note=Ig-like C2-type 4
HSPG2	P98160	3064	3109	3022	3112	Domain	Note=Ig-like C2-type 16
HSPG2	P98160	3890	3923	3884	3922	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HSPG2	P98160	3923	3997	3928	4103	Domain	Note=Laminin G-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
HSPG2	P98160	4136	4177	4104	4141	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HSPG2	P98160	4136	4177	4143	4176	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
HSPG2	P98160	4272	4299	4201	4389	Domain	Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
HSPG2	P98160	4136	4177	4149	4151	Region	Note=Mediates motor neuron attachment;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSPG2	P98160	4272	4299	4299	4301	Region	Note=Mediates motor neuron attachment;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSPG2	P98160	4272	4299	4275	4275	Metal binding	Note=Calcium%3B via carbonyl oxygen
HSPG2	P98160	4177	4196	4196	4197	Site	Note=Cleavage%3B by BMP1
HSPG2	P98160	3064	3109	3072	3072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
HSPG2	P98160	3064	3109	3105	3105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSPG2	P98160	3923	3997	3933	3933	Glycosylation	Note=O-linked (Xyl...) (chondroitin sulfate) serine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSPG2	P98160	4177	4196	4179	4179	Glycosylation	Note=O-linked (Xyl...) (chondroitin sulfate) serine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSPG2	P98160	1219	1247	1209	1224	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	1219	1247	1211	1234	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	1219	1247	1237	1246	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	1542	1580	1563	1572	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	1542	1580	1565	1579	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	3890	3923	3888	3899	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	3890	3923	3893	3910	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	3890	3923	3912	3921	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	4136	4177	4131	4140	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	4136	4177	4147	4159	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	4136	4177	4153	4164	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	4136	4177	4166	4175	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
HSPG2	P98160	1900	1951	1919	1919	Natural variant	ID=VAR_047985;Note=R->C;Dbxref=dbSNP:rs2229474
HSPG2	P98160	1219	1247	1222	1222	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPG2	P98160	1343	1407	1406	1406	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPG2	P98160	1671	1727	1703	1704	Sequence conflict	Note=SP->RG;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPG2	P98160	4272	4299	4268	4274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SH4
HSPG2	P98160	4272	4299	4279	4283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SH4
HSPG2	P98160	4272	4299	4290	4292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SH4
HSPG2	P98160	4272	4299	4294	4301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SH4
RAD50	Q92878	345	406	1	1312	Chain	ID=PRO_0000138641;Note=DNA repair protein RAD50
RAD50	Q92878	804	835	1	1312	Chain	ID=PRO_0000138641;Note=DNA repair protein RAD50
RAD50	Q92878	345	406	228	359	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAD50	Q92878	345	406	401	598	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAD50	Q92878	804	835	789	1079	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
POGLUT1	Q8NBL1	59	106	24	392	Chain	ID=PRO_0000246685;Note=Protein O-glucosyltransferase 1
POGLUT1	Q8NBL1	59	106	103	107	Region	Note=Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28775322;Dbxref=PMID:28775322
POGLUT1	Q8NBL1	59	106	54	357	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5L0R,ECO:0000244|PDB:5L0S,ECO:0000244|PDB:5L0T,ECO:0000244|PDB:5L0U,ECO:0000244|PDB:5L0V,ECO:0000244|PDB:5UB5,ECO:0000269|PubMed:28775322;Dbxref=PMID:28775322
POGLUT1	Q8NBL1	59	106	102	108	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5L0R,ECO:0000244|PDB:5L0S,ECO:0000244|PDB:5L0T,ECO:0000244|PDB:5L0U,ECO:0000244|PDB:5L0V,ECO:0000244|PDB:5UB5,ECO:0000269|PubMed:28775322;Dbxref=PMID:28775322
POGLUT1	Q8NBL1	59	106	75	75	Natural variant	ID=VAR_027041;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11556605,PMID:15489334
POGLUT1	Q8NBL1	59	106	58	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0V
POGLUT1	Q8NBL1	59	106	66	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0V
POGLUT1	Q8NBL1	59	106	74	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0V
POGLUT1	Q8NBL1	59	106	85	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0V
POGLUT1	Q8NBL1	59	106	95	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0V
POGLUT1	Q8NBL1	59	106	105	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5L0V
RANBP9	Q96S59	245	301	1	729	Chain	ID=PRO_0000097169;Note=Ran-binding protein 9
RANBP9	Q96S59	245	301	147	334	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
RANBP9	Q96S59	245	301	1	341	Alternative sequence	ID=VSP_013175;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RANBP9	Q96S59	245	301	251	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RANBP9	Q96S59	245	301	256	258	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RANBP9	Q96S59	245	301	260	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RANBP9	Q96S59	245	301	280	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RANBP9	Q96S59	245	301	287	290	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RANBP9	Q96S59	245	301	291	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RANBP9	Q96S59	245	301	299	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7
RAB22A	Q9UL26	66	90	1	194	Chain	ID=PRO_0000121209;Note=Ras-related protein Rab-22A
PHTF1	Q9UMS5	557	601	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	423	466	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	163	207	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	57	110	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	557	601	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	423	466	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	163	207	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PHTF1	Q9UMS5	57	110	1	762	Chain	ID=PRO_0000127423;Note=Putative homeodomain transcription factor 1
PICALM	Q13492	613	648	2	652	Chain	ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein
PICALM	Q13492	593	613	2	652	Chain	ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein
PICALM	Q13492	469	505	2	652	Chain	ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein
PICALM	Q13492	419	469	2	652	Chain	ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein
PICALM	Q13492	255	269	2	652	Chain	ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein
PICALM	Q13492	255	269	221	294	Region	Note=Interaction with PIMREG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16491119;Dbxref=PMID:16491119
PICALM	Q13492	613	648	648	649	Site	Note=Breakpoint for translocation to form CALM/MLLT10 fusion protein
PICALM	Q13492	469	505	420	469	Alternative sequence	ID=VSP_009607;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PICALM	Q13492	419	469	420	469	Alternative sequence	ID=VSP_009607;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
PICALM	Q13492	419	469	420	426	Alternative sequence	ID=VSP_044568;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PICALM	Q13492	593	613	593	593	Alternative sequence	ID=VSP_009608;Note=In isoform 3. M->MNGMHFPQY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PICALM	Q13492	613	648	594	613	Alternative sequence	ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689
PICALM	Q13492	593	613	594	613	Alternative sequence	ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689
PICALM	Q13492	613	648	641	641	Natural variant	ID=VAR_028195;Note=F->L;Dbxref=dbSNP:rs556337
PICK1	Q9NRD5	51	94	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	146	164	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	164	185	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	261	278	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	51	94	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	146	164	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	164	185	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	261	278	1	415	Chain	ID=PRO_0000058427;Note=PRKCA-binding protein
PICK1	Q9NRD5	51	94	22	105	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PICK1	Q9NRD5	51	94	22	105	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PICK1	Q9NRD5	146	164	144	357	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
PICK1	Q9NRD5	164	185	144	357	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
PICK1	Q9NRD5	261	278	144	357	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
PICK1	Q9NRD5	146	164	144	357	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
PICK1	Q9NRD5	164	185	144	357	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
PICK1	Q9NRD5	261	278	144	357	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
PICK1	Q9NRD5	51	94	82	82	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20403402;Dbxref=PMID:20403402
PICK1	Q9NRD5	51	94	82	82	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20403402;Dbxref=PMID:20403402
PICK1	Q9NRD5	51	94	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	57	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	57	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	69	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	69	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	83	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PICK1	Q9NRD5	51	94	83	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GZV
PIFO	Q8TCI5	53	86	1	191	Chain	ID=PRO_0000284526;Note=Protein pitchfork
PIFO	Q8TCI5	53	86	54	86	Alternative sequence	ID=VSP_042040;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIFO	Q8TCI5	53	86	80	80	Natural variant	ID=VAR_066484;Note=Found in patients with severe ciliopathies and left-right asymmetry defects%3B inhibits AURKA activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20643351;Dbxref=dbSNP:rs150508940,PMID:20643351
PIFO	Q8TCI5	53	86	63	63	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIGN	O95427	417	478	1	931	Chain	ID=PRO_0000246198;Note=GPI ethanolamine phosphate transferase 1
PIGN	O95427	321	341	1	931	Chain	ID=PRO_0000246198;Note=GPI ethanolamine phosphate transferase 1
PIGN	O95427	417	478	1	931	Chain	ID=PRO_0000246198;Note=GPI ethanolamine phosphate transferase 1
PIGN	O95427	321	341	1	931	Chain	ID=PRO_0000246198;Note=GPI ethanolamine phosphate transferase 1
PIGN	O95427	417	478	25	442	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	321	341	25	442	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	417	478	25	442	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	321	341	25	442	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	417	478	443	463	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	417	478	443	463	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	417	478	464	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	417	478	464	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PIGN	O95427	417	478	469	469	Natural variant	ID=VAR_053575;Note=L->F;Dbxref=dbSNP:rs3862712
PIGN	O95427	417	478	469	469	Natural variant	ID=VAR_053575;Note=L->F;Dbxref=dbSNP:rs3862712
PIGN	O95427	417	478	470	470	Natural variant	ID=VAR_053576;Note=I->L;Dbxref=dbSNP:rs3862712
PIGN	O95427	417	478	470	470	Natural variant	ID=VAR_053576;Note=I->L;Dbxref=dbSNP:rs3862712
PINLYP	A6NC86	113	160	27	204	Chain	ID=PRO_0000332737;Note=phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
PINLYP	A6NC86	113	160	27	117	Domain	Note=UPAR/Ly6
PINLYP	A6NC86	113	160	126	151	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PINLYP	A6NC86	113	160	144	172	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PINLYP	A6NC86	113	160	63	204	Alternative sequence	ID=VSP_044190;Note=In isoform 3. KGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQSDGCNSAFLSVPLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVLFLHHIECTHSP->SKRMWPGTWWGGGVYLQGGRDYHAEGGSSRFSRRERGKKSVESRKEGKTIMRWREQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIK3CA	P42336	468	513	1	1068	Chain	ID=PRO_0000088785;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit alpha isoform
PIK3CA	P42336	468	513	330	487	Domain	Note=C2 PI3K-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00880
PIK3CA	P42336	468	513	468	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JPS
PIK3CA	P42336	468	513	472	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JPS
PIK3CA	P42336	468	513	481	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXT
PIK3CA	P42336	468	513	489	492	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JPS
PIK3CA	P42336	468	513	495	498	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RD0
PIK3CA	P42336	468	513	504	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SWP
PIK3CA	P42336	468	513	508	512	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DXT
PIK3CA	P42336	468	513	513	515	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5SXB
PLEKHH1	Q9ULM0	42	63	1	1364	Chain	ID=PRO_0000310948;Note=Pleckstrin homology domain-containing family H member 1
PLEKHH1	Q9ULM0	63	113	1	1364	Chain	ID=PRO_0000310948;Note=Pleckstrin homology domain-containing family H member 1
PLEKHH1	Q9ULM0	113	141	1	1364	Chain	ID=PRO_0000310948;Note=Pleckstrin homology domain-containing family H member 1
PLEKHH1	Q9ULM0	696	723	1	1364	Chain	ID=PRO_0000310948;Note=Pleckstrin homology domain-containing family H member 1
PLEKHH1	Q9ULM0	696	723	687	796	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
PLEKHH1	Q9ULM0	42	63	28	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PLEKHH1	Q9ULM0	63	113	28	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PLEKHH1	Q9ULM0	113	141	28	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PLEKHH1	Q9ULM0	42	63	1	485	Alternative sequence	ID=VSP_029347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHH1	Q9ULM0	63	113	1	485	Alternative sequence	ID=VSP_029347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHH1	Q9ULM0	113	141	1	485	Alternative sequence	ID=VSP_029347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLEKHH1	Q9ULM0	63	113	75	75	Natural variant	ID=VAR_037094;Note=N->S;Dbxref=dbSNP:rs7150973
PLEKHH1	Q9ULM0	63	113	113	113	Natural variant	ID=VAR_037095;Note=Q->L;Dbxref=dbSNP:rs3825723
PLEKHH1	Q9ULM0	113	141	113	113	Natural variant	ID=VAR_037095;Note=Q->L;Dbxref=dbSNP:rs3825723
PKD2L1	Q9P0L9	244	318	1	805	Chain	ID=PRO_0000164360;Note=Polycystic kidney disease 2-like 1 protein
PKD2L1	Q9P0L9	244	318	125	313	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKD2L1	Q9P0L9	244	318	314	334	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PKD2L1	Q9P0L9	244	318	225	344	Alternative sequence	ID=VSP_004728;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10602361;Dbxref=PMID:10602361
PKD2L1	Q9P0L9	244	318	245	319	Alternative sequence	ID=VSP_004729;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PKD2L1	Q9P0L9	244	318	278	278	Natural variant	ID=VAR_050555;Note=R->Q;Dbxref=dbSNP:rs17112895
PIK3CG	P48736	797	846	1	1102	Chain	ID=PRO_0000088792;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit gamma isoform
PIK3CG	P48736	797	846	1	1102	Chain	ID=PRO_0000088792;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit gamma isoform
PIK3CG	P48736	797	846	1	1102	Chain	ID=PRO_0000088792;Note=Phosphatidylinositol 4%2C5-bisphosphate 3-kinase catalytic subunit gamma isoform
PIK3CG	P48736	797	846	828	1073	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PIK3CG	P48736	797	846	828	1073	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PIK3CG	P48736	797	846	828	1073	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
PIK3CG	P48736	797	846	829	838	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PIK3CG	P48736	797	846	829	838	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PIK3CG	P48736	797	846	829	838	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
PIK3CG	P48736	797	846	833	833	Mutagenesis	Note=Reduced inflammatory reactions but no alterations in cardiac contractility. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15294162;Dbxref=PMID:15294162
PIK3CG	P48736	797	846	833	833	Mutagenesis	Note=Reduced inflammatory reactions but no alterations in cardiac contractility. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15294162;Dbxref=PMID:15294162
PIK3CG	P48736	797	846	833	833	Mutagenesis	Note=Reduced inflammatory reactions but no alterations in cardiac contractility. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15294162;Dbxref=PMID:15294162
PIK3CG	P48736	797	846	798	800	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	798	800	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	798	800	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	806	808	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	806	808	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	806	808	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	811	818	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	811	818	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	811	818	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	828	836	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	828	836	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	828	836	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	838	856	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	838	856	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PIK3CG	P48736	797	846	838	856	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1E8Y
PSMD10	O75832	71	120	1	226	Chain	ID=PRO_0000067045;Note=26S proteasome non-ATPase regulatory subunit 10
PSMD10	O75832	71	120	70	102	Repeat	Note=ANK 3
PSMD10	O75832	71	120	103	135	Repeat	Note=ANK 4
PSMD10	O75832	71	120	1	71	Region	Note=Interaction with RB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10613832;Dbxref=PMID:10613832
PSMD10	O75832	71	120	39	226	Region	Note=Interaction with RELA
PSMD10	O75832	71	120	71	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TR4
PSMD10	O75832	71	120	76	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH
PSMD10	O75832	71	120	86	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH
PSMD10	O75832	71	120	109	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH
PSMD10	O75832	71	120	119	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UOH
PSMD11	O00231	149	214	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	283	304	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	304	346	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	346	358	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	149	214	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	283	304	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	304	346	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	346	358	2	422	Chain	ID=PRO_0000173857;Note=26S proteasome non-ATPase regulatory subunit 11
PSMD11	O00231	283	304	224	392	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD11	O00231	304	346	224	392	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD11	O00231	346	358	224	392	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD11	O00231	283	304	224	392	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD11	O00231	304	346	224	392	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD11	O00231	346	358	224	392	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD14	O00487	40	80	1	310	Chain	ID=PRO_0000213952;Note=26S proteasome non-ATPase regulatory subunit 14
PSMD14	O00487	190	215	1	310	Chain	ID=PRO_0000213952;Note=26S proteasome non-ATPase regulatory subunit 14
PSMD14	O00487	215	257	1	310	Chain	ID=PRO_0000213952;Note=26S proteasome non-ATPase regulatory subunit 14
PSMD14	O00487	257	278	1	310	Chain	ID=PRO_0000213952;Note=26S proteasome non-ATPase regulatory subunit 14
PSMD14	O00487	40	80	31	166	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
PSMD14	O00487	215	257	224	224	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17323924;Dbxref=PMID:17323924
PSMD14	O00487	257	278	266	266	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSMG2	Q969U7	136	193	1	264	Chain	ID=PRO_0000322552;Note=Proteasome assembly chaperone 2
PSMG2	Q969U7	136	193	137	137	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSMG2	Q969U7	136	193	164	164	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMD3	O43242	137	183	1	534	Chain	ID=PRO_0000173816;Note=26S proteasome non-ATPase regulatory subunit 3
PSMD3	O43242	365	405	1	534	Chain	ID=PRO_0000173816;Note=26S proteasome non-ATPase regulatory subunit 3
PSMD3	O43242	440	492	1	534	Chain	ID=PRO_0000173816;Note=26S proteasome non-ATPase regulatory subunit 3
PSMD3	O43242	492	509	1	534	Chain	ID=PRO_0000173816;Note=26S proteasome non-ATPase regulatory subunit 3
PSMD3	O43242	365	405	286	465	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD3	O43242	440	492	286	465	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD3	O43242	137	183	1	138	Alternative sequence	ID=VSP_056362;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PSMD3	O43242	492	509	493	534	Alternative sequence	ID=VSP_056363;Note=In isoform 2. AMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP->GW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PSMD3	O43242	137	183	157	158	Sequence conflict	Note=TP->NT;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMD5	Q16401	271	335	2	504	Chain	ID=PRO_0000173835;Note=26S proteasome non-ATPase regulatory subunit 5
PSMD5	Q16401	144	187	2	504	Chain	ID=PRO_0000173835;Note=26S proteasome non-ATPase regulatory subunit 5
PSMD5	Q16401	144	187	145	187	Alternative sequence	ID=VSP_045176;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	365	382	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
PTCD3	Q96EY7	382	412	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
PTCD3	Q96EY7	607	659	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
PTCD3	Q96EY7	365	382	331	367	Repeat	Note=PPR 5
PTCD3	Q96EY7	365	382	368	409	Repeat	Note=PPR 6
PTCD3	Q96EY7	382	412	368	409	Repeat	Note=PPR 6
PTCD3	Q96EY7	382	412	412	446	Repeat	Note=PPR 7
PTCD3	Q96EY7	365	382	1	409	Alternative sequence	ID=VSP_028191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	382	412	1	409	Alternative sequence	ID=VSP_028191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	382	412	410	413	Alternative sequence	ID=VSP_028192;Note=In isoform 2. PDDD->MMAY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	382	412	400	400	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTS	Q03393	62	81	1	145	Chain	ID=PRO_0000057914;Note=6-pyruvoyl tetrahydrobiopterin synthase
PTS	Q03393	62	81	67	67	Natural variant	ID=VAR_006824;Note=In HPABH4A. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11388593,ECO:0000269|PubMed:9222757;Dbxref=dbSNP:rs370340361,PMID:11388593,PMID:9222757
PTS	Q03393	62	81	70	70	Natural variant	ID=VAR_006825;Note=In HPABH4A. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9450907;Dbxref=PMID:9450907
PTS	Q03393	62	81	49	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I2B
PTS	Q03393	62	81	65	67	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I2B
PTS	Q03393	62	81	73	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I2B
PTPRS	Q13332	1349	1365	30	1948	Chain	ID=PRO_0000025462;Note=Receptor-type tyrosine-protein phosphatase S
PTPRS	Q13332	329	523	30	1948	Chain	ID=PRO_0000025462;Note=Receptor-type tyrosine-protein phosphatase S
PTPRS	Q13332	329	523	30	1282	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRS	Q13332	1349	1365	1304	1948	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRS	Q13332	329	523	334	424	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRS	Q13332	329	523	429	523	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRS	Q13332	1349	1365	1350	1365	Alternative sequence	ID=VSP_050026;Note=In isoform PTPS-MEB%2C isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8992885;Dbxref=PMID:15489334,PMID:8992885
PTPRS	Q13332	329	523	428	429	Sequence conflict	Note=SA->RP;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRS	Q13332	329	523	339	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	348	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	361	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	377	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	384	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	397	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	410	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	417	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	431	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	443	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	457	466	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	472	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	475	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	482	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	496	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PTPRS	Q13332	329	523	516	524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBX
PSG5	Q15238	236	321	35	335	Chain	ID=PRO_0000014912;Note=Pregnancy-specific beta-1-glycoprotein 5
PSG5	Q15238	236	321	35	335	Chain	ID=PRO_0000014912;Note=Pregnancy-specific beta-1-glycoprotein 5
PSG5	Q15238	236	321	35	335	Chain	ID=PRO_0000014912;Note=Pregnancy-specific beta-1-glycoprotein 5
PSG5	Q15238	236	321	239	317	Domain	Note=Ig-like C2-type 2
PSG5	Q15238	236	321	239	317	Domain	Note=Ig-like C2-type 2
PSG5	Q15238	236	321	239	317	Domain	Note=Ig-like C2-type 2
PSG5	Q15238	236	321	261	301	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	261	301	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	261	301	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	240	240	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	240	240	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	240	240	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	288	288	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	288	288	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG5	Q15238	236	321	288	288	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFTPB	P07988	143	206	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	101	143	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	77	101	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	194	224	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	131	194	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	89	131	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	65	89	25	200	Propeptide	ID=PRO_0000031647
SFTPB	P07988	206	236	201	279	Chain	ID=PRO_0000031648;Note=Pulmonary surfactant-associated protein B
SFTPB	P07988	143	206	201	279	Chain	ID=PRO_0000031648;Note=Pulmonary surfactant-associated protein B
SFTPB	P07988	194	224	201	279	Chain	ID=PRO_0000031648;Note=Pulmonary surfactant-associated protein B
SFTPB	P07988	346	373	280	381	Propeptide	ID=PRO_0000031649
SFTPB	P07988	334	361	280	381	Propeptide	ID=PRO_0000031649
SFTPB	P07988	65	89	25	65	Domain	Note=Saposin A-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00414
SFTPB	P07988	143	206	65	147	Domain	Note=Saposin B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	101	143	65	147	Domain	Note=Saposin B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	77	101	65	147	Domain	Note=Saposin B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	131	194	65	147	Domain	Note=Saposin B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	89	131	65	147	Domain	Note=Saposin B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	65	89	65	147	Domain	Note=Saposin B-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	206	236	204	281	Domain	Note=Saposin B-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	143	206	204	281	Domain	Note=Saposin B-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	194	224	204	281	Domain	Note=Saposin B-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	346	373	295	370	Domain	Note=Saposin B-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	334	361	295	370	Domain	Note=Saposin B-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	101	143	129	129	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	89	131	129	129	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	143	206	69	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	101	143	69	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	77	101	69	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	131	194	69	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	89	131	69	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	65	89	69	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	101	143	72	137	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	77	101	72	137	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	131	194	72	137	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	89	131	72	137	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	65	89	72	137	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	101	143	100	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	77	101	100	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	89	131	100	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	206	236	208	277	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00415,ECO:0000269|PubMed:1568474;Dbxref=PMID:1568474
SFTPB	P07988	194	224	208	277	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00415,ECO:0000269|PubMed:1568474;Dbxref=PMID:1568474
SFTPB	P07988	206	236	211	271	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00415,ECO:0000269|PubMed:1568474;Dbxref=PMID:1568474
SFTPB	P07988	194	224	211	271	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00415,ECO:0000269|PubMed:1568474;Dbxref=PMID:1568474
SFTPB	P07988	206	236	235	246	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00415,ECO:0000269|PubMed:1568474;Dbxref=PMID:1568474
SFTPB	P07988	346	373	299	366	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	334	361	299	366	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	346	373	302	360	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	334	361	302	360	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	334	361	325	335	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00415
SFTPB	P07988	101	143	131	131	Natural variant	ID=VAR_006948;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11076040,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1130866,PMID:11076040
SFTPB	P07988	131	194	131	131	Natural variant	ID=VAR_006948;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11076040,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1130866,PMID:11076040
SFTPB	P07988	89	131	131	131	Natural variant	ID=VAR_006948;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11076040,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1130866,PMID:11076040
SFTPB	P07988	143	206	176	176	Natural variant	ID=VAR_013099;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs3024801
SFTPB	P07988	131	194	176	176	Natural variant	ID=VAR_013099;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs3024801
SFTPB	P07988	206	236	228	228	Natural variant	ID=VAR_006950;Note=Requires 2 nucleotide substitutions. A->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1568474;Dbxref=PMID:1568474
SFTPB	P07988	206	236	228	228	Natural variant	ID=VAR_006949;Note=Requires 2 nucleotide substitutions. A->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2924687,ECO:0000269|PubMed:3035561;Dbxref=PMID:2924687,PMID:3035561
SFTPB	P07988	206	236	236	236	Natural variant	ID=VAR_036856;Note=In SMDP1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7491219;Dbxref=dbSNP:rs137853202,PMID:7491219
SFTPB	P07988	143	206	178	178	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFTPB	P07988	131	194	178	178	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFTPB	P07988	206	236	213	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMR
SFTPB	P07988	194	224	213	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KMR
RPL13A	P40429	29	51	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	51	85	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	114	134	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	134	175	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	51	85	59	59	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL13A	P40429	51	85	77	77	Modified residue	Note=Phosphoserine%3B by ZIPK/DAPK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18995835;Dbxref=PMID:18995835
RPL13A	P40429	134	175	140	140	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL13A	P40429	51	85	77	77	Mutagenesis	Note=Loss of interferon-gamma induced phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18995835;Dbxref=PMID:18995835
PTGDS	P41222	149	183	23	190	Chain	ID=PRO_0000017945;Note=Prostaglandin-H2 D-isomerase
PTGDS	P41222	149	183	89	186	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PTGDS	P41222	149	183	149	149	Mutagenesis	Note=Increases enzyme activity about two-fold. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20667974;Dbxref=PMID:20667974
PTGDS	P41222	149	183	144	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O22
PTGDS	P41222	149	183	157	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O22
PTGDS	P41222	149	183	174	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O22
PTGDS	P41222	149	183	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O22
PTK6	Q13882	122	176	1	451	Chain	ID=PRO_0000088133;Note=Protein-tyrosine kinase 6
PTK6	Q13882	122	176	78	170	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
PTK6	Q13882	122	176	171	190	Region	Note=Linker
PTK6	Q13882	122	176	78	134	Alternative sequence	ID=VSP_042066;Note=In isoform 2. WFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAG->AGHAGCAALQDLAACRGPAAPERGGVLPQPARACELPQGPEPVPRPAAGRALPEARA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9333026;Dbxref=PMID:14702039,PMID:9333026
PTK6	Q13882	122	176	135	451	Alternative sequence	ID=VSP_042067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9333026;Dbxref=PMID:14702039,PMID:9333026
PTK6	Q13882	122	176	125	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJA
PTK6	Q13882	122	176	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJA
PTK6	Q13882	122	176	137	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJA
PTK6	Q13882	122	176	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJA
PTK6	Q13882	122	176	148	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJA
PTK6	Q13882	122	176	162	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJA
PTPN1	P18031	164	234	1	435	Chain	ID=PRO_0000094748;Note=Tyrosine-protein phosphatase non-receptor type 1
PTPN1	P18031	164	234	3	277	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN1	P18031	164	234	215	221	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTPN1	P18031	164	234	215	215	Active site	Note=Phosphocysteine intermediate
PTPN1	P18031	164	234	181	181	Binding site	Note=Substrate
PTPN1	P18031	164	234	215	215	Modified residue	Note=Cysteine persulfide%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22169477;Dbxref=PMID:22169477
PTPN1	P18031	164	234	215	215	Modified residue	Note=Cysteine sulfenic acid (-SOH)%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12802338,ECO:0000269|PubMed:12802339;Dbxref=PMID:12802338,PMID:12802339
PTPN1	P18031	164	234	215	215	Modified residue	Note=Cysteine sulfinic acid (-SO2H)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12802339;Dbxref=PMID:12802339
PTPN1	P18031	164	234	215	215	Modified residue	Note=S-nitrosocysteine%3B in reversibly inhibited form;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22169477;Dbxref=PMID:22169477
PTPN1	P18031	164	234	215	216	Cross-link	Note=N%2CN-(cysteine-1%2CS-diyl)serine (Cys-Ser)%3B in inhibited form;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12802338,ECO:0000269|PubMed:12802339;Dbxref=PMID:12802338,PMID:12802339
PTPN1	P18031	164	234	181	181	Mutagenesis	Note=Substrate-trapping mutant. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22169477;Dbxref=PMID:22169477
PTPN1	P18031	164	234	215	215	Mutagenesis	Note=Catalytically inactive mutant%3B abolishes sulfhydration. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22169477;Dbxref=PMID:22169477
PTPN1	P18031	164	234	163	165	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	168	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	181	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	186	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	189	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	201	204	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	211	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN1	P18031	164	234	221	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CM2
PTPN4	P29074	123	137	1	926	Chain	ID=PRO_0000219434;Note=Tyrosine-protein phosphatase non-receptor type 4
PTPN4	P29074	334	356	1	926	Chain	ID=PRO_0000219434;Note=Tyrosine-protein phosphatase non-receptor type 4
PTPN4	P29074	399	451	1	926	Chain	ID=PRO_0000219434;Note=Tyrosine-protein phosphatase non-receptor type 4
PTPN4	P29074	505	533	1	926	Chain	ID=PRO_0000219434;Note=Tyrosine-protein phosphatase non-receptor type 4
PTPN4	P29074	123	137	29	312	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTPN4	P29074	505	533	517	589	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PTPN4	P29074	123	137	131	131	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPN4	P29074	505	533	516	520	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NFK
PTPN4	P29074	505	533	524	526	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CS5
PTPN4	P29074	505	533	530	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NFK
PTPRN2	Q92932	806	832	22	1015	Chain	ID=PRO_0000025454;Note=Receptor-type tyrosine-protein phosphatase N2
PTPRN2	Q92932	596	667	22	1015	Chain	ID=PRO_0000025454;Note=Receptor-type tyrosine-protein phosphatase N2
PTPRN2	Q92932	519	547	22	1015	Chain	ID=PRO_0000025454;Note=Receptor-type tyrosine-protein phosphatase N2
PTPRN2	Q92932	303	377	22	1015	Chain	ID=PRO_0000025454;Note=Receptor-type tyrosine-protein phosphatase N2
PTPRN2	Q92932	54	92	22	1015	Chain	ID=PRO_0000025454;Note=Receptor-type tyrosine-protein phosphatase N2
PTPRN2	Q92932	37	54	22	1015	Chain	ID=PRO_0000025454;Note=Receptor-type tyrosine-protein phosphatase N2
PTPRN2	Q92932	806	832	502	1015	Chain	ID=PRO_0000438088;Note=IA-2beta60;Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560,ECO:0000250|UniProtKB:Q63475
PTPRN2	Q92932	596	667	502	1015	Chain	ID=PRO_0000438088;Note=IA-2beta60;Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560,ECO:0000250|UniProtKB:Q63475
PTPRN2	Q92932	519	547	502	1015	Chain	ID=PRO_0000438088;Note=IA-2beta60;Ontology_term=ECO:0000250,ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560,ECO:0000250|UniProtKB:Q63475
PTPRN2	Q92932	596	667	22	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	519	547	22	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	303	377	22	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	54	92	22	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	37	54	22	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	596	667	616	636	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	806	832	637	1015	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	596	667	637	1015	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN2	Q92932	806	832	745	1005	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRN2	Q92932	303	377	1	421	Region	Note=Involved in localization to secretory granules%3B interaction with CPE;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560
PTPRN2	Q92932	54	92	1	421	Region	Note=Involved in localization to secretory granules%3B interaction with CPE;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560
PTPRN2	Q92932	37	54	1	421	Region	Note=Involved in localization to secretory granules%3B interaction with CPE;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560
PTPRN2	Q92932	596	667	666	675	Motif	Note=Tyrosine-based internalization motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63475
PTPRN2	Q92932	37	54	1	37	Alternative sequence	ID=VSP_035264;Note=In isoform 3. MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRL->MAVESEYSLLRTEASFPTMKMFCVSHTLPRVEVMFVSGPQTRERTEPVDPRWQCLVQMWA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
PTPRN2	Q92932	54	92	38	54	Alternative sequence	ID=VSP_045032;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
PTPRN2	Q92932	37	54	38	54	Alternative sequence	ID=VSP_045032;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
PTPRN2	Q92932	519	547	519	547	Alternative sequence	ID=VSP_007779;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRN2	Q92932	303	377	325	325	Natural variant	ID=VAR_020302;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8954911,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1130499,PMID:8954911
PTPRN2	Q92932	303	377	343	343	Natural variant	ID=VAR_022015;Note=V->M;Dbxref=dbSNP:rs3752368
PTPRN2	Q92932	303	377	323	323	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRN2	Q92932	519	547	523	536	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HTI
PTPRN2	Q92932	519	547	541	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HTI
PTPRN2	Q92932	519	547	544	550	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HTI
PTPRN2	Q92932	806	832	802	806	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QEP
PTPRN2	Q92932	806	832	811	813	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QEP
PTPRN2	Q92932	806	832	815	819	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QEP
PTPRN2	Q92932	806	832	824	826	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QEP
PTPRN2	Q92932	806	832	827	836	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QEP
PTPRM	P28827	24	65	21	1452	Chain	ID=PRO_0000025448;Note=Receptor-type tyrosine-protein phosphatase mu
PTPRM	P28827	377	480	21	1452	Chain	ID=PRO_0000025448;Note=Receptor-type tyrosine-protein phosphatase mu
PTPRM	P28827	817	842	21	1452	Chain	ID=PRO_0000025448;Note=Receptor-type tyrosine-protein phosphatase mu
PTPRM	P28827	1005	1044	21	1452	Chain	ID=PRO_0000025448;Note=Receptor-type tyrosine-protein phosphatase mu
PTPRM	P28827	1249	1293	21	1452	Chain	ID=PRO_0000025448;Note=Receptor-type tyrosine-protein phosphatase mu
PTPRM	P28827	24	65	21	742	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	377	480	21	742	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	817	842	765	1452	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	1005	1044	765	1452	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	1249	1293	765	1452	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	24	65	22	184	Domain	Note=MAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00128
PTPRM	P28827	377	480	284	379	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRM	P28827	377	480	382	480	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRM	P28827	1005	1044	900	1154	Domain	Note=Tyrosine-protein phosphatase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRM	P28827	1249	1293	1186	1448	Domain	Note=Tyrosine-protein phosphatase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRM	P28827	817	842	821	821	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PTPRM	P28827	377	480	406	406	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	377	480	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	377	480	454	454	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRM	P28827	24	65	27	36	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16456543;Dbxref=PMID:16456543
PTPRM	P28827	817	842	842	842	Alternative sequence	ID=VSP_046677;Note=In isoform 2. P->PDPFVPTAILVPIN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRM	P28827	24	65	39	39	Natural variant	ID=VAR_046634;Note=S->R;Dbxref=dbSNP:rs35224276
PTPRM	P28827	24	65	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C9A
PTPRM	P28827	24	65	33	36	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C9A
PTPRM	P28827	24	65	42	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C9A
PTPRM	P28827	24	65	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C9A
PTPRM	P28827	24	65	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C9A
PTPRM	P28827	377	480	384	391	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	396	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	405	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	410	412	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	414	434	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	454	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	467	469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	377	480	473	476	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V5Y
PTPRM	P28827	1005	1044	1014	1019	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RPM
PTPRM	P28827	1005	1044	1022	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RPM
PTPRM	P28827	1005	1044	1035	1044	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RPM
PSMA3	P25788	159	181	2	255	Chain	ID=PRO_0000124091;Note=Proteasome subunit alpha type-3
PSMA3	P25788	159	181	158	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA3	P25788	159	181	170	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSD	A5PKW4	667	697	1	1024	Chain	ID=PRO_0000318298;Note=PH and SEC7 domain-containing protein 1
PSD	A5PKW4	518	582	1	1024	Chain	ID=PRO_0000318298;Note=PH and SEC7 domain-containing protein 1
PSD	A5PKW4	667	697	1	1024	Chain	ID=PRO_0000318298;Note=PH and SEC7 domain-containing protein 1
PSD	A5PKW4	518	582	1	1024	Chain	ID=PRO_0000318298;Note=PH and SEC7 domain-containing protein 1
PSD	A5PKW4	667	697	512	706	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
PSD	A5PKW4	518	582	512	706	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
PSD	A5PKW4	667	697	512	706	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
PSD	A5PKW4	518	582	512	706	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
PSD	A5PKW4	518	582	537	537	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSD	A5PKW4	518	582	537	537	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSD4	Q8NDX1	352	391	1	1056	Chain	ID=PRO_0000251731;Note=PH and SEC7 domain-containing protein 4
PSD4	Q8NDX1	543	612	1	1056	Chain	ID=PRO_0000251731;Note=PH and SEC7 domain-containing protein 4
PSD4	Q8NDX1	613	639	1	1056	Chain	ID=PRO_0000251731;Note=PH and SEC7 domain-containing protein 4
PSD4	Q8NDX1	543	612	544	736	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
PSD4	Q8NDX1	613	639	544	736	Domain	Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189
PSD4	Q8NDX1	613	639	637	637	Natural variant	ID=VAR_051923;Note=R->Q;Dbxref=dbSNP:rs45487591
RPL12	P30050	97	126	1	165	Chain	ID=PRO_0000104456;Note=60S ribosomal protein L12
RPL12	P30050	37	70	1	165	Chain	ID=PRO_0000104456;Note=60S ribosomal protein L12
RPL12	P30050	37	70	38	38	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163
RPL12	P30050	37	70	54	54	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL12	P30050	37	70	40	40	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL12	P30050	37	70	38	70	Alternative sequence	ID=VSP_034695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTER	Q96BW5	233	279	1	349	Chain	ID=PRO_0000205364;Note=Phosphotriesterase-related protein
PTER	Q96BW5	233	279	1	349	Chain	ID=PRO_0000205364;Note=Phosphotriesterase-related protein
PTER	Q96BW5	233	279	234	280	Alternative sequence	ID=VSP_038342;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTER	Q96BW5	233	279	234	280	Alternative sequence	ID=VSP_038342;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTER	Q96BW5	233	279	234	234	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTER	Q96BW5	233	279	234	234	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTER	Q96BW5	233	279	259	259	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTER	Q96BW5	233	279	259	259	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTH1R	Q03431	59	104	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	451	465	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	59	104	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	451	465	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	59	104	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	451	465	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	59	104	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	451	465	27	593	Chain	ID=PRO_0000012845;Note=Parathyroid hormone/parathyroid hormone-related peptide receptor
PTH1R	Q03431	59	104	27	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	59	104	27	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	59	104	27	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	59	104	27	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	441	463	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	441	463	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	441	463	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	441	463	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	464	593	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	464	593	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	464	593	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	451	465	464	593	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH1R	Q03431	59	104	48	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3C4M,ECO:0000244|PDB:3H3G,ECO:0000244|PDB:3L2J,ECO:0000269|PubMed:10913300,ECO:0000269|PubMed:18375760,ECO:0000269|PubMed:19674967;Dbxref=PMID:10913300,PMID:18375760,PMID:19674967
PTH1R	Q03431	59	104	48	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3C4M,ECO:0000244|PDB:3H3G,ECO:0000244|PDB:3L2J,ECO:0000269|PubMed:10913300,ECO:0000269|PubMed:18375760,ECO:0000269|PubMed:19674967;Dbxref=PMID:10913300,PMID:18375760,PMID:19674967
PTH1R	Q03431	59	104	48	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3C4M,ECO:0000244|PDB:3H3G,ECO:0000244|PDB:3L2J,ECO:0000269|PubMed:10913300,ECO:0000269|PubMed:18375760,ECO:0000269|PubMed:19674967;Dbxref=PMID:10913300,PMID:18375760,PMID:19674967
PTH1R	Q03431	59	104	48	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3C4M,ECO:0000244|PDB:3H3G,ECO:0000244|PDB:3L2J,ECO:0000269|PubMed:10913300,ECO:0000269|PubMed:18375760,ECO:0000269|PubMed:19674967;Dbxref=PMID:10913300,PMID:18375760,PMID:19674967
PTH1R	Q03431	451	465	458	458	Natural variant	ID=VAR_016064;Note=In JMC. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10487664;Dbxref=dbSNP:rs121434600,PMID:10487664
PTH1R	Q03431	451	465	458	458	Natural variant	ID=VAR_016064;Note=In JMC. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10487664;Dbxref=dbSNP:rs121434600,PMID:10487664
PTH1R	Q03431	451	465	458	458	Natural variant	ID=VAR_016064;Note=In JMC. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10487664;Dbxref=dbSNP:rs121434600,PMID:10487664
PTH1R	Q03431	451	465	458	458	Natural variant	ID=VAR_016064;Note=In JMC. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10487664;Dbxref=dbSNP:rs121434600,PMID:10487664
PTPRB	P23467	993	1083	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
PTPRB	P23467	641	729	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
PTPRB	P23467	465	552	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
PTPRB	P23467	375	465	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
PTPRB	P23467	287	375	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
PTPRB	P23467	993	1083	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	641	729	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	465	552	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	375	465	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	287	375	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	287	375	203	288	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	375	465	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	287	375	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	465	552	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	375	465	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	465	552	467	552	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	641	729	556	641	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	641	729	642	729	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	993	1083	909	1001	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	993	1083	995	1083	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRB	P23467	287	375	321	321	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	375	465	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	375	465	421	421	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	465	552	479	479	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	465	552	544	544	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	641	729	652	652	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	641	729	721	721	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	993	1083	1040	1040	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRB	P23467	465	552	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRB	P23467	375	465	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRB	P23467	993	1083	997	1086	Alternative sequence	ID=VSP_053944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRB	P23467	375	465	395	395	Natural variant	ID=VAR_057135;Note=V->A;Dbxref=dbSNP:rs36027530
PTPRB	P23467	375	465	415	415	Natural variant	ID=VAR_057136;Note=D->E;Dbxref=dbSNP:rs2165627
PTPRB	P23467	993	1083	1032	1032	Natural variant	ID=VAR_057138;Note=T->I;Dbxref=dbSNP:rs34902691
PTPRB	P23467	641	729	666	666	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTDSS1	P48651	90	105	2	473	Chain	ID=PRO_0000056829;Note=Phosphatidylserine synthase 1
PTDSS1	P48651	336	357	2	473	Chain	ID=PRO_0000056829;Note=Phosphatidylserine synthase 1
PTDSS1	P48651	391	414	2	473	Chain	ID=PRO_0000056829;Note=Phosphatidylserine synthase 1
PTDSS1	P48651	90	105	73	93	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	90	105	94	102	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	90	105	103	123	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	336	357	320	342	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	336	357	343	355	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	336	357	356	376	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	391	414	384	404	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	391	414	405	473	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTDSS1	P48651	90	105	1	203	Alternative sequence	ID=VSP_057421;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTDSS1	P48651	90	105	1	146	Alternative sequence	ID=VSP_055980;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTDSS1	P48651	336	357	353	353	Natural variant	ID=VAR_070989;Note=In LMHD%3B does not affect protein levels%3B increases the rate of phosphatidylserine synthesis%3B profoundly impairs negative feedback enzyme regulation by phosphatidylserine. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24241535;Dbxref=dbSNP:rs587777088,PMID:24241535
PTPRF	P10586	126	189	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	226	316	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	316	510	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	604	706	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	819	1012	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	1457	1497	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	1746	1788	30	1907	Chain	ID=PRO_0000025432;Note=Receptor-type tyrosine-protein phosphatase F
PTPRF	P10586	126	189	30	1263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	226	316	30	1263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	316	510	30	1263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	604	706	30	1263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	819	1012	30	1263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	1457	1497	1285	1907	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	1746	1788	1285	1907	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	126	189	135	224	Domain	Note=Ig-like C2-type 2
PTPRF	P10586	226	316	232	314	Domain	Note=Ig-like C2-type 3
PTPRF	P10586	316	510	321	411	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	316	510	416	510	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	604	706	514	604	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	604	706	609	706	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	819	1012	711	819	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	819	1012	820	914	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	819	1012	918	1010	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRF	P10586	1457	1497	1352	1607	Domain	Note=Tyrosine-protein phosphatase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRF	P10586	1746	1788	1639	1898	Domain	Note=Tyrosine-protein phosphatase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRF	P10586	226	316	250	250	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	226	316	295	295	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRF	P10586	819	1012	966	966	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19349973;Dbxref=PMID:16335952,PMID:19349973
PTPRF	P10586	126	189	156	207	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PTPRF	P10586	226	316	253	298	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
PTPRF	P10586	316	510	412	412	Natural variant	ID=VAR_054766;Note=A->V;Dbxref=dbSNP:rs1065775
PTPRF	P10586	316	510	450	450	Natural variant	ID=VAR_020299;Note=Y->C;Dbxref=dbSNP:rs3748796
PTPRF	P10586	604	706	646	646	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRF	P10586	126	189	127	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	136	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	144	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	152	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	157	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	165	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	126	189	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	226	316	221	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YD8
PTPRF	P10586	316	510	323	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJU
PTPRF	P10586	316	510	334	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJU
PTPRF	P10586	316	510	348	356	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJU
PTPRF	P10586	316	510	371	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJU
PTPRF	P10586	316	510	384	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJU
PTPRF	P10586	316	510	404	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJU
PTPRF	P10586	604	706	611	619	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	622	628	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	632	634	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	639	652	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	657	663	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	667	671	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	679	690	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	692	695	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	604	706	699	702	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N5U
PTPRF	P10586	819	1012	825	830	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	835	841	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	852	859	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	866	871	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	876	880	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	887	896	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	899	909	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN7
PTPRF	P10586	819	1012	920	923	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDY
PTPRF	P10586	819	1012	925	927	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDY
PTPRF	P10586	819	1012	935	937	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDY
PTPRF	P10586	819	1012	950	957	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDY
PTPRF	P10586	819	1012	963	971	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDY
PTPRF	P10586	819	1012	984	987	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDY
PTPRF	P10586	1457	1497	1466	1472	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1457	1497	1475	1484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1457	1497	1486	1497	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1746	1788	1746	1749	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1746	1788	1755	1757	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1746	1788	1759	1761	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1746	1788	1764	1773	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1746	1788	1775	1786	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRF	P10586	1746	1788	1787	1789	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LAR
PTPRO	Q16827	220	368	30	1216	Chain	ID=PRO_0000025458;Note=Receptor-type tyrosine-protein phosphatase O
PTPRO	Q16827	876	903	30	1216	Chain	ID=PRO_0000025458;Note=Receptor-type tyrosine-protein phosphatase O
PTPRO	Q16827	220	368	30	822	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	876	903	844	1216	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	220	368	246	306	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRO	Q16827	220	368	329	425	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRO	Q16827	220	368	227	227	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	220	368	278	278	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	220	368	287	287	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	220	368	323	323	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	220	368	324	324	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRO	Q16827	220	368	1	811	Alternative sequence	ID=VSP_043136;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10498613,ECO:0000303|PubMed:14702039;Dbxref=PMID:10498613,PMID:14702039
PTPRO	Q16827	876	903	598	1216	Alternative sequence	ID=VSP_054482;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRO	Q16827	876	903	876	903	Alternative sequence	ID=VSP_035586;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10498613,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7665166;Dbxref=PMID:10498613,PMID:14702039,PMID:7665166
PTPRO	Q16827	220	368	314	314	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRO	Q16827	876	903	876	876	Sequence conflict	Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRO	Q16827	876	903	876	876	Sequence conflict	Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRO	Q16827	876	903	896	896	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRO	Q16827	876	903	896	896	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAICS	P22234	5	71	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	191	229	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	229	257	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	317	370	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	5	71	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	191	229	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	229	257	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	317	370	2	425	Chain	ID=PRO_0000075030;Note=Multifunctional protein ADE2
PAICS	P22234	5	71	2	260	Region	Note=SAICAR synthetase
PAICS	P22234	191	229	2	260	Region	Note=SAICAR synthetase
PAICS	P22234	229	257	2	260	Region	Note=SAICAR synthetase
PAICS	P22234	5	71	2	260	Region	Note=SAICAR synthetase
PAICS	P22234	191	229	2	260	Region	Note=SAICAR synthetase
PAICS	P22234	229	257	2	260	Region	Note=SAICAR synthetase
PAICS	P22234	317	370	267	425	Region	Note=AIR carboxylase
PAICS	P22234	317	370	267	425	Region	Note=AIR carboxylase
PAICS	P22234	191	229	215	215	Active site	Note=For SAICAR synthetase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	191	229	215	215	Active site	Note=For SAICAR synthetase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	317	370	332	332	Active site	Note=For AIR carboxylase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	317	370	332	332	Active site	Note=For AIR carboxylase activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	317	370	334	334	Site	Note=Essential for AIR carboxylase activity
PAICS	P22234	317	370	334	334	Site	Note=Essential for AIR carboxylase activity
PAICS	P22234	5	71	22	22	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCL9
PAICS	P22234	5	71	22	22	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCL9
PAICS	P22234	5	71	27	27	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17924679,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PAICS	P22234	5	71	27	27	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17924679,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PAICS	P22234	5	71	36	36	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCL9
PAICS	P22234	5	71	36	36	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCL9
PAICS	P22234	229	257	238	238	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:23186163
PAICS	P22234	229	257	238	238	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:23186163
PAICS	P22234	229	257	247	247	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PAICS	P22234	229	257	247	247	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PAICS	P22234	191	229	201	201	Natural variant	ID=VAR_051884;Note=K->N;Dbxref=dbSNP:rs11549976
PAICS	P22234	191	229	201	201	Natural variant	ID=VAR_051884;Note=K->N;Dbxref=dbSNP:rs11549976
PAICS	P22234	317	370	332	332	Mutagenesis	Note=Loss of AIR carboxylase activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	317	370	332	332	Mutagenesis	Note=Loss of AIR carboxylase activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	317	370	334	334	Mutagenesis	Note=Loss of AIR carboxylase activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	317	370	334	334	Mutagenesis	Note=Loss of AIR carboxylase activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224163;Dbxref=PMID:17224163
PAICS	P22234	191	229	217	217	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAICS	P22234	191	229	217	217	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAICS	P22234	317	370	340	340	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAICS	P22234	317	370	340	340	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAICS	P22234	5	71	20	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	5	71	20	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	5	71	32	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	5	71	32	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	5	71	54	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	5	71	54	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	186	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	186	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	194	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	194	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	198	200	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	198	200	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	213	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	191	229	213	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	229	257	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	229	257	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	229	257	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	229	257	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	229	257	256	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	229	257	256	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	306	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	306	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	323	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	323	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	335	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	335	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	347	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	347	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	355	357	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	355	357	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	358	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	358	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	362	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PAICS	P22234	317	370	362	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H31
PSMB4	P28070	192	231	46	264	Chain	ID=PRO_0000026580;Note=Proteasome subunit beta type-4
PSMB4	P28070	192	231	212	214	Natural variant	ID=VAR_075255;Note=Found in a patient with Nakajo syndrome%3B unknown pathological significance%3B patients' cells show proteasome assembly defects. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26524591;Dbxref=PMID:26524591
PSMB4	P28070	192	231	192	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMB4	P28070	192	231	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A0Q
PSMB4	P28070	192	231	207	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSCA	O43653	8	44	1	11	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
PSCA	O43653	8	44	12	86	Chain	ID=PRO_0000036162;Note=Prostate stem cell antigen
PSCA	O43653	8	44	12	86	Domain	Note=UPAR/Ly6
PSCA	O43653	8	44	31	31	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSCA	O43653	8	44	14	39	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57
PSCA	O43653	8	44	17	26	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57
PSCA	O43653	8	44	32	57	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0DP57
PSCA	O43653	8	44	30	30	Natural variant	ID=VAR_020173;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18488030;Dbxref=dbSNP:rs3736001,PMID:18488030
GINS1	Q14691	110	149	1	196	Chain	ID=PRO_0000219035;Note=DNA replication complex GINS protein PSF1
GINS1	Q14691	110	149	108	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS1	Q14691	110	149	128	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
PSPC1	Q8WXF1	225	256	1	523	Chain	ID=PRO_0000297540;Note=Paraspeckle component 1
PSPC1	Q8WXF1	225	256	156	237	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PSPC1	Q8WXF1	225	256	125	358	Region	Note=Sufficient for paraspeckles localization
PSPC1	Q8WXF1	225	256	231	358	Region	Note=Sufficient for perinucleolar caps localization and interaction with NONO;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16148043;Dbxref=PMID:16148043
PSPC1	Q8WXF1	225	256	221	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SDE
PSPC1	Q8WXF1	225	256	231	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SDE
PSPC1	Q8WXF1	225	256	238	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SDE
PSPC1	Q8WXF1	225	256	246	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SDE
PSPC1	Q8WXF1	225	256	253	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SDE
PSMD7	P51665	55	86	1	324	Chain	ID=PRO_0000213943;Note=26S proteasome non-ATPase regulatory subunit 7
PSMD7	P51665	55	86	9	144	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
PSMD7	P51665	55	86	36	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O95
PSMD7	P51665	55	86	58	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O95
PSMD7	P51665	55	86	67	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O95
PSMD7	P51665	55	86	72	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O95
PSMD7	P51665	55	86	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O95
PTBP2	Q9UKA9	463	488	1	531	Chain	ID=PRO_0000232928;Note=Polypyrimidine tract-binding protein 2
PTBP2	Q9UKA9	463	488	455	529	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PTBP2	Q9UKA9	463	488	357	531	Alternative sequence	ID=VSP_018017;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11694331,ECO:0000303|PubMed:12213192;Dbxref=PMID:11694331,PMID:12213192
PTBP2	Q9UKA9	463	488	468	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQ1
PTBP2	Q9UKA9	463	488	477	479	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQ1
PTBP2	Q9UKA9	463	488	482	487	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQ1
PTCD2	Q8WV60	276	314	1	388	Chain	ID=PRO_0000344050;Note=Pentatricopeptide repeat-containing protein 2%2C mitochondrial
PTH2R	P49190	405	419	25	550	Chain	ID=PRO_0000012849;Note=Parathyroid hormone 2 receptor
PTH2R	P49190	405	419	395	417	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTH2R	P49190	405	419	418	550	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAG1	Q8WVM7	1149	1185	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	979	1021	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	895	929	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	759	790	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	732	759	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	611	679	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	402	437	1	1258	Chain	ID=PRO_0000120182;Note=Cohesin subunit SA-1
STAG1	Q8WVM7	732	759	756	756	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
STAG1	Q8WVM7	1149	1185	1161	1161	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
STAG1	Q8WVM7	1149	1185	1150	1186	Alternative sequence	ID=VSP_054496;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STAG1	Q8WVM7	979	1021	979	979	Natural variant	ID=VAR_079494;Note=In MRD47. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28119487;Dbxref=PMID:28119487
STAG1	Q8WVM7	611	679	645	645	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAG2	Q8N3U4	399	434	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	891	925	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	975	1017	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	399	434	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	891	925	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	975	1017	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	399	434	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	891	925	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	975	1017	1	1231	Chain	ID=PRO_0000120185;Note=Cohesin subunit SA-2
STAG2	Q8N3U4	975	1017	992	992	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAG2	Q8N3U4	975	1017	992	992	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAG2	Q8N3U4	975	1017	992	992	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAG2	Q8N3U4	399	434	384	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	384	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	384	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	402	404	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	407	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	407	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	407	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	416	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	416	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	416	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	419	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	419	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	419	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	422	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	422	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	399	434	422	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	887	892	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	887	892	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	887	892	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	893	908	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	893	908	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	893	908	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	912	934	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	912	934	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	891	925	912	934	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	968	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	968	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	968	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	982	984	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJU
STAG2	Q8N3U4	975	1017	982	984	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJU
STAG2	Q8N3U4	975	1017	982	984	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJU
STAG2	Q8N3U4	975	1017	987	989	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	987	989	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	987	989	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	995	998	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PK7
STAG2	Q8N3U4	975	1017	995	998	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PK7
STAG2	Q8N3U4	975	1017	995	998	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PK7
STAG2	Q8N3U4	975	1017	999	1003	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	999	1003	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	999	1003	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	1004	1009	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	1004	1009	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	1004	1009	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	1012	1022	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	1012	1022	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAG2	Q8N3U4	975	1017	1012	1022	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJW
STAM	Q92783	67	99	2	540	Chain	ID=PRO_0000190145;Note=Signal transducing adapter molecule 1
STAM	Q92783	67	99	16	143	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
STAM	Q92783	67	99	59	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LDZ
STAM	Q92783	67	99	78	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LDZ
STAM	Q92783	67	99	87	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LDZ
TMEM173	Q86WV6	0	75	1	379	Chain	ID=PRO_0000271116;Note=Stimulator of interferon genes protein
TMEM173	Q86WV6	0	75	1	20	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM173	Q86WV6	0	75	21	41	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM173	Q86WV6	0	75	42	46	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM173	Q86WV6	0	75	47	67	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM173	Q86WV6	0	75	68	86	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM173	Q86WV6	0	75	71	71	Natural variant	ID=VAR_029863;Note=R->H;Dbxref=dbSNP:rs11554776
TMEM173	Q86WV6	0	75	20	20	Mutagenesis	Note=Does not affect amount of ubiquitination. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21074459;Dbxref=PMID:21074459
NR5A1	Q13285	290	330	1	461	Chain	ID=PRO_0000053729;Note=Steroidogenic factor 1
NR5A1	Q13285	290	330	222	459	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
NR5A1	Q13285	290	330	230	461	Region	Note=Important for dimerization
NR5A1	Q13285	290	330	293	293	Natural variant	ID=VAR_062970;Note=In POF7%3B without adrenal failure%3B partial loss of activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19246354;Dbxref=dbSNP:rs121918655,PMID:19246354
NR5A1	Q13285	290	330	291	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZDT
NR5A1	Q13285	290	330	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZDT
NR5A1	Q13285	290	330	326	328	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YOW
NR5A1	Q13285	290	330	330	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZDT
STAT4	Q14765	402	417	1	748	Chain	ID=PRO_0000182420;Note=Signal transducer and activator of transcription 4
STAT4	Q14765	314	344	1	748	Chain	ID=PRO_0000182420;Note=Signal transducer and activator of transcription 4
STAT4	Q14765	402	417	1	748	Chain	ID=PRO_0000182420;Note=Signal transducer and activator of transcription 4
STAT4	Q14765	314	344	1	748	Chain	ID=PRO_0000182420;Note=Signal transducer and activator of transcription 4
STK38	Q15208	102	130	2	465	Chain	ID=PRO_0000086718;Note=Serine/threonine-protein kinase 38
STK38	Q15208	102	130	89	382	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000312;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000312|EMBL:CAA84485.1
STK38	Q15208	102	130	95	103	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:O95835,ECO:0000255|PROSITE-ProRule:PRU00159
STK38	Q15208	102	130	118	118	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:12493777,ECO:0000269|PubMed:7761441;Dbxref=PMID:12493777,PMID:7761441
STK38	Q15208	102	130	118	118	Mutagenesis	Note=Loss of autophosphorylation and kinase activity. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12493777,ECO:0000269|PubMed:7761441;Dbxref=PMID:12493777,PMID:7761441
SUV39H1	O43463	276	325	1	412	Chain	ID=PRO_0000186057;Note=Histone-lysine N-methyltransferase SUV39H1
SUV39H1	O43463	276	325	243	366	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SUV39H1	O43463	276	325	255	377	Region	Note=Mediates interaction with MECOM;Ontology_term=ECO:0000250;evidence=ECO:0000250
SUV39H1	O43463	276	325	323	324	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
SUV39H1	O43463	276	325	297	297	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SUV39H1	O43463	276	325	320	320	Mutagenesis	Note=Strongly increases methylation of histone H3. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10949293;Dbxref=PMID:10949293
SUV39H1	O43463	276	325	324	324	Mutagenesis	Note=Abolishes methylation of histone H3. H->L%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10949293;Dbxref=PMID:10949293
SLC50A1	Q9BRV3	27	52	1	221	Chain	ID=PRO_0000345116;Note=Sugar transporter SWEET1
SLC50A1	Q9BRV3	94	148	1	221	Chain	ID=PRO_0000345116;Note=Sugar transporter SWEET1
SLC50A1	Q9BRV3	27	52	42	62	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC50A1	Q9BRV3	94	148	96	116	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC50A1	Q9BRV3	94	148	129	149	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC50A1	Q9BRV3	27	52	10	94	Domain	Note=MtN3/slv 1
SLC50A1	Q9BRV3	94	148	10	94	Domain	Note=MtN3/slv 1
SLC50A1	Q9BRV3	94	148	127	212	Domain	Note=MtN3/slv 2
SLC50A1	Q9BRV3	27	52	1	55	Alternative sequence	ID=VSP_034916;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10931946;Dbxref=PMID:10931946
SLC50A1	Q9BRV3	94	148	56	94	Alternative sequence	ID=VSP_034917;Note=In isoform 2. GWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRK->MRGLHPWHVLRRPLGPQAHANDPECGQRPVPALSHHGSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10931946;Dbxref=PMID:10931946
SLC50A1	Q9BRV3	94	148	95	148	Alternative sequence	ID=VSP_034918;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC50A1	Q9BRV3	27	52	43	43	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC50A1	Q9BRV3	94	148	130	130	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SWAP70	Q9UH65	80	138	1	585	Chain	ID=PRO_0000240280;Note=Switch-associated protein 70
SWAP70	Q9UH65	138	214	1	585	Chain	ID=PRO_0000240280;Note=Switch-associated protein 70
SWAP70	Q9UH65	360	396	1	585	Chain	ID=PRO_0000240280;Note=Switch-associated protein 70
SWAP70	Q9UH65	138	214	210	306	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SWAP70	Q9UH65	360	396	316	539	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SWAP70	Q9UH65	360	396	385	385	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SWAP70	Q9UH65	138	214	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DN6
SWT1	Q5T5J6	322	342	1	900	Chain	ID=PRO_0000251184;Note=Transcriptional protein SWT1
SWT1	Q5T5J6	379	413	1	900	Chain	ID=PRO_0000251184;Note=Transcriptional protein SWT1
SWT1	Q5T5J6	770	813	1	900	Chain	ID=PRO_0000251184;Note=Transcriptional protein SWT1
SWT1	Q5T5J6	322	342	1	900	Chain	ID=PRO_0000251184;Note=Transcriptional protein SWT1
SWT1	Q5T5J6	379	413	1	900	Chain	ID=PRO_0000251184;Note=Transcriptional protein SWT1
SWT1	Q5T5J6	770	813	1	900	Chain	ID=PRO_0000251184;Note=Transcriptional protein SWT1
SWT1	Q5T5J6	379	413	388	515	Domain	Note=PINc
SWT1	Q5T5J6	379	413	388	515	Domain	Note=PINc
PTP4A3	O75365	110	134	1	170	Chain	ID=PRO_0000094788;Note=Protein tyrosine phosphatase type IVA 3
PTP4A3	O75365	110	134	1	170	Chain	ID=PRO_0000094788;Note=Protein tyrosine phosphatase type IVA 3
PTP4A3	O75365	110	134	82	148	Domain	Note=Tyrosine-protein phosphatase
PTP4A3	O75365	110	134	82	148	Domain	Note=Tyrosine-protein phosphatase
PTP4A3	O75365	110	134	110	110	Binding site	Note=Substrate
PTP4A3	O75365	110	134	110	110	Binding site	Note=Substrate
PTP4A3	O75365	110	134	39	124	Alternative sequence	ID=VSP_014406;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PTP4A3	O75365	110	134	39	124	Alternative sequence	ID=VSP_014406;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
PTP4A3	O75365	110	134	111	135	Alternative sequence	ID=VSP_014407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PTP4A3	O75365	110	134	111	135	Alternative sequence	ID=VSP_014407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
PTP4A3	O75365	110	134	111	111	Mutagenesis	Note=Enhances catalytic activity. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14704153;Dbxref=PMID:14704153
PTP4A3	O75365	110	134	111	111	Mutagenesis	Note=Enhances catalytic activity. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14704153;Dbxref=PMID:14704153
PTP4A3	O75365	110	134	110	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TSR
PTP4A3	O75365	110	134	110	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TSR
PTP4A3	O75365	110	134	126	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TSR
PTP4A3	O75365	110	134	126	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TSR
SYCP2L	Q5T4T6	651	685	1	812	Chain	ID=PRO_0000333809;Note=Synaptonemal complex protein 2-like
SYCP2L	Q5T4T6	651	685	292	812	Alternative sequence	ID=VSP_033545;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SYCP2L	Q5T4T6	651	685	626	812	Natural variant	ID=VAR_079007;Note=Rare polymorphism%3B abolishes localization to centromeres. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26362258;Dbxref=PMID:26362258
SYCP2L	Q5T4T6	651	685	642	812	Natural variant	ID=VAR_079008;Note=Rare polymorphism%3B abolishes localization to centromeres. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26362258;Dbxref=PMID:26362258
SYCP2L	Q5T4T6	651	685	672	672	Natural variant	ID=VAR_043171;Note=Common polymorphism%3B does not affect localization to centromeres. P->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17374641,ECO:0000269|PubMed:26362258;Dbxref=dbSNP:rs1225746,PMID:15489334,PMID:17374641,PMID:26362258
TP53BP1	Q12888	1691	1763	1	1972	Chain	ID=PRO_0000072643;Note=TP53-binding protein 1
TP53BP1	Q12888	1362	1411	1	1972	Chain	ID=PRO_0000072643;Note=TP53-binding protein 1
TP53BP1	Q12888	1028	1058	1	1972	Chain	ID=PRO_0000072643;Note=TP53-binding protein 1
TP53BP1	Q12888	900	940	1	1972	Chain	ID=PRO_0000072643;Note=TP53-binding protein 1
TP53BP1	Q12888	1691	1763	1724	1848	Domain	Note=BRCT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033
TP53BP1	Q12888	1362	1411	1396	1403	Motif	Note=GAR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16294045;Dbxref=PMID:16294045
TP53BP1	Q12888	1691	1763	1760	1764	Compositional bias	Note=Poly-Glu
TP53BP1	Q12888	900	940	922	922	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TP53BP1	Q12888	1028	1058	1028	1028	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:17553757;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:17553757
TP53BP1	Q12888	1028	1058	1056	1056	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TP53BP1	Q12888	1362	1411	1362	1362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TP53BP1	Q12888	1362	1411	1368	1368	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TP53BP1	Q12888	1362	1411	1372	1372	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TP53BP1	Q12888	1691	1763	1701	1701	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TP53BP1	Q12888	1691	1763	1759	1759	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TP53BP1	Q12888	900	940	930	930	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
TP53BP1	Q12888	1362	1411	1365	1365	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TP53BP1	Q12888	1691	1763	1692	1693	Alternative sequence	ID=VSP_055062;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TP53BP1	Q12888	1362	1411	1396	1396	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). Loss of methylation%3B when associated with A-1398%3B A-1400%3B A-1401 and A-1403. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1396	1396	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1398	1401	Mutagenesis	Note=No effect on in class-switch recombination (CSR). RGRR->AGAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23345425;Dbxref=PMID:23345425
TP53BP1	Q12888	1362	1411	1398	1398	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). Loss of methylation%3B when associated with A-1396%3B A-1400%3B A-1401 and A-1403. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1398	1398	Mutagenesis	Note=Reduced methylation by PRMT1 (in vitro). Strongly reduced methylation%3B when associated with K-1400. Strongly reduced methylation%3B when associated with K-1401. R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1400	1400	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). Loss of methylation%3B when associated with A-1396%3B A-1398%3B A-1401 and A-1403. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1400	1400	Mutagenesis	Note=Reduced methylation by PRMT1 (in vitro). Strongly reduced methylation%3B when associated with K-1398. Strongly reduced methylation%3B when associated with K-1401. R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1401	1401	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). Loss of methylation%3B when associated with A-1396%3B A-1398%3B A-1400 and A-1403. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1401	1401	Mutagenesis	Note=Reduced methylation by PRMT1 (in vitro). Strongly reduced methylation%3B when associated with K-1398. Strongly reduced methylation%3B when associated with K-1400. R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1403	1403	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). Loss of methylation%3B when associated with A-1396%3B A-1398%3B A-1400 and A-1401. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1362	1411	1403	1403	Mutagenesis	Note=No detectable effect on methylation by PRMT1 (in vitro). R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16294045,ECO:0000269|PubMed:16294047;Dbxref=PMID:16294045,PMID:16294047
TP53BP1	Q12888	1691	1763	1715	1719	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KZY
TP53BP1	Q12888	1691	1763	1726	1731	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KZY
TP53BP1	Q12888	1691	1763	1732	1736	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KZY
TP53BP1	Q12888	1691	1763	1741	1745	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GZH
DARS2	Q6PI48	98	132	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	132	164	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	340	376	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	376	397	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	397	448	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	521	558	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	521	558	535	535	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
DARS2	Q6PI48	521	558	542	542	Binding site	Note=Aspartate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DARS2	Q6PI48	376	397	382	382	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DARS2	Q6PI48	132	164	152	152	Natural variant	ID=VAR_037016;Note=In LBSL. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17384640;Dbxref=dbSNP:rs121918208,PMID:17384640
TPCN2	Q8NHX9	381	410	1	752	Chain	ID=PRO_0000276856;Note=Two pore calcium channel protein 2
TPCN2	Q8NHX9	563	587	1	752	Chain	ID=PRO_0000276856;Note=Two pore calcium channel protein 2
TPCN2	Q8NHX9	381	410	311	436	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN2	Q8NHX9	563	587	555	575	Transmembrane	Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN2	Q8NHX9	563	587	576	580	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN2	Q8NHX9	563	587	581	601	Transmembrane	Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN2	Q8NHX9	563	587	564	564	Natural variant	ID=VAR_030493;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:19387438;Dbxref=dbSNP:rs2376558,PMID:15489334,PMID:17974005,PMID:19387438
SLC25A19	Q9HC21	96	153	1	320	Chain	ID=PRO_0000090611;Note=Mitochondrial thiamine pyrophosphate carrier
SLC25A19	Q9HC21	96	153	1	320	Chain	ID=PRO_0000090611;Note=Mitochondrial thiamine pyrophosphate carrier
SLC25A19	Q9HC21	96	153	1	320	Chain	ID=PRO_0000090611;Note=Mitochondrial thiamine pyrophosphate carrier
SLC25A19	Q9HC21	96	153	1	320	Chain	ID=PRO_0000090611;Note=Mitochondrial thiamine pyrophosphate carrier
SLC25A19	Q9HC21	96	153	1	320	Chain	ID=PRO_0000090611;Note=Mitochondrial thiamine pyrophosphate carrier
SLC25A19	Q9HC21	96	153	87	107	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	87	107	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	87	107	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	87	107	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	87	107	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	122	142	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	122	142	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	122	142	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	122	142	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	122	142	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A19	Q9HC21	96	153	13	106	Repeat	Note=Solcar 1
SLC25A19	Q9HC21	96	153	13	106	Repeat	Note=Solcar 1
SLC25A19	Q9HC21	96	153	13	106	Repeat	Note=Solcar 1
SLC25A19	Q9HC21	96	153	13	106	Repeat	Note=Solcar 1
SLC25A19	Q9HC21	96	153	13	106	Repeat	Note=Solcar 1
SLC25A19	Q9HC21	96	153	116	202	Repeat	Note=Solcar 2
SLC25A19	Q9HC21	96	153	116	202	Repeat	Note=Solcar 2
SLC25A19	Q9HC21	96	153	116	202	Repeat	Note=Solcar 2
SLC25A19	Q9HC21	96	153	116	202	Repeat	Note=Solcar 2
SLC25A19	Q9HC21	96	153	116	202	Repeat	Note=Solcar 2
SLC25A19	Q9HC21	96	153	97	153	Alternative sequence	ID=VSP_053908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SLC25A19	Q9HC21	96	153	97	153	Alternative sequence	ID=VSP_053908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SLC25A19	Q9HC21	96	153	97	153	Alternative sequence	ID=VSP_053908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SLC25A19	Q9HC21	96	153	97	153	Alternative sequence	ID=VSP_053908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SLC25A19	Q9HC21	96	153	97	153	Alternative sequence	ID=VSP_053908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SLC25A19	Q9HC21	96	153	125	125	Natural variant	ID=VAR_065125;Note=In THMD4%3B affects function as shown by complementation studies in yeast. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19798730;Dbxref=dbSNP:rs387906944,PMID:19798730
SLC25A19	Q9HC21	96	153	125	125	Natural variant	ID=VAR_065125;Note=In THMD4%3B affects function as shown by complementation studies in yeast. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19798730;Dbxref=dbSNP:rs387906944,PMID:19798730
SLC25A19	Q9HC21	96	153	125	125	Natural variant	ID=VAR_065125;Note=In THMD4%3B affects function as shown by complementation studies in yeast. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19798730;Dbxref=dbSNP:rs387906944,PMID:19798730
SLC25A19	Q9HC21	96	153	125	125	Natural variant	ID=VAR_065125;Note=In THMD4%3B affects function as shown by complementation studies in yeast. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19798730;Dbxref=dbSNP:rs387906944,PMID:19798730
SLC25A19	Q9HC21	96	153	125	125	Natural variant	ID=VAR_065125;Note=In THMD4%3B affects function as shown by complementation studies in yeast. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19798730;Dbxref=dbSNP:rs387906944,PMID:19798730
HARS	P12081	437	486	2	509	Chain	ID=PRO_0000136332;Note=Histidine--tRNA ligase%2C cytoplasmic
HARS	P12081	210	243	2	509	Chain	ID=PRO_0000136332;Note=Histidine--tRNA ligase%2C cytoplasmic
HARS	P12081	174	210	2	509	Chain	ID=PRO_0000136332;Note=Histidine--tRNA ligase%2C cytoplasmic
HARS	P12081	60	100	2	509	Chain	ID=PRO_0000136332;Note=Histidine--tRNA ligase%2C cytoplasmic
HARS	P12081	174	210	177	177	Binding site	Note=L-histidine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4PHC,ECO:0000269|PubMed:25151410;Dbxref=PMID:25151410
HARS	P12081	60	100	66	66	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KK9
HARS	P12081	60	100	60	99	Alternative sequence	ID=VSP_045118;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HARS	P12081	174	210	155	174	Alternative sequence	ID=VSP_046662;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
HARS	P12081	174	210	175	175	Natural variant	ID=VAR_075066;Note=In CMT2W%3B hypomorphic mutation. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26072516;Dbxref=dbSNP:rs863225123,PMID:26072516
HARS	P12081	174	210	205	205	Natural variant	ID=VAR_069023;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22930593;Dbxref=dbSNP:rs147288996,PMID:22930593
HARS	P12081	210	243	238	238	Natural variant	ID=VAR_069024;Note=In CMT2W%3B unknown pathological significance. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22930593;Dbxref=dbSNP:rs536175170,PMID:22930593
HARS	P12081	437	486	454	454	Natural variant	ID=VAR_067918;Note=In USH3B. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22279524;Dbxref=dbSNP:rs387906639,PMID:22279524
HARS	P12081	174	210	181	181	Sequence conflict	Note=N->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS	P12081	174	210	186	186	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS	P12081	174	210	191	191	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS	P12081	174	210	206	206	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS	P12081	210	243	223	223	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS	P12081	210	243	227	227	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS	P12081	60	100	67	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	60	100	96	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	60	100	100	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	174	210	169	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	174	210	186	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	210	243	207	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	174	210	207	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	210	243	214	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	210	243	228	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	210	243	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	437	486	438	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G85
HARS	P12081	437	486	442	445	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X5O
HARS	P12081	437	486	448	458	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	437	486	462	465	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	437	486	468	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	437	486	475	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	437	486	481	483	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
HARS	P12081	437	486	486	490	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G84
TRABD	Q9H4I3	93	140	1	376	Chain	ID=PRO_0000050825;Note=TraB domain-containing protein
TRABD	Q9H4I3	140	177	1	376	Chain	ID=PRO_0000050825;Note=TraB domain-containing protein
TRABD	Q9H4I3	93	140	1	376	Chain	ID=PRO_0000050825;Note=TraB domain-containing protein
TRABD	Q9H4I3	140	177	1	376	Chain	ID=PRO_0000050825;Note=TraB domain-containing protein
TRABD	Q9H4I3	93	140	1	376	Chain	ID=PRO_0000050825;Note=TraB domain-containing protein
TRABD	Q9H4I3	140	177	1	376	Chain	ID=PRO_0000050825;Note=TraB domain-containing protein
TRAF2	Q12933	89	122	2	501	Chain	ID=PRO_0000056399;Note=TNF receptor-associated factor 2
TRAF2	Q12933	122	176	2	501	Chain	ID=PRO_0000056399;Note=TNF receptor-associated factor 2
TRAF2	Q12933	176	201	2	501	Chain	ID=PRO_0000056399;Note=TNF receptor-associated factor 2
TRAF2	Q12933	201	226	2	501	Chain	ID=PRO_0000056399;Note=TNF receptor-associated factor 2
TRAF2	Q12933	122	176	124	180	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF2	Q12933	176	201	124	180	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF2	Q12933	176	201	177	233	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF2	Q12933	201	226	177	233	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF2	Q12933	89	122	117	117	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19150425;Dbxref=PMID:19150425
TRAF2	Q12933	89	122	122	122	Alternative sequence	ID=VSP_007401;Note=In isoform 2. E->EVKMPACGMVTEAPAVGSRPRSPSSYDLVLHVPLTGAEACLMSVEEETELLLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF2	Q12933	122	176	122	122	Alternative sequence	ID=VSP_007401;Note=In isoform 2. E->EVKMPACGMVTEAPAVGSRPRSPSSYDLVLHVPLTGAEACLMSVEEETELLLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF2	Q12933	122	176	176	200	Alternative sequence	ID=VSP_039688;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TRAF2	Q12933	176	201	176	200	Alternative sequence	ID=VSP_039688;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TRAF2	Q12933	89	122	117	117	Mutagenesis	Note=Loss of phosphorylation site. Abolishes activation of NF-kappa-B. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19150425;Dbxref=PMID:19150425
TRAF2	Q12933	201	226	205	310	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAF2	Q12933	89	122	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	89	122	94	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	89	122	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	89	122	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	89	122	118	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	122	176	118	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	122	176	125	127	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAF2	Q12933	122	176	130	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KNV
TRAM1	Q15629	249	296	1	374	Chain	ID=PRO_0000185530;Note=Translocating chain-associated membrane protein 1
TRAM1	Q15629	214	248	1	374	Chain	ID=PRO_0000185530;Note=Translocating chain-associated membrane protein 1
TRAM1	Q15629	103	142	1	374	Chain	ID=PRO_0000185530;Note=Translocating chain-associated membrane protein 1
TRAM1	Q15629	103	142	98	121	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91V04
TRAM1	Q15629	103	142	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAM1	Q15629	214	248	214	217	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91V04
TRAM1	Q15629	214	248	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAM1	Q15629	249	296	239	251	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91V04
TRAM1	Q15629	214	248	239	251	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91V04
TRAM1	Q15629	249	296	252	272	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAM1	Q15629	249	296	273	297	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91V04
TRAM1	Q15629	249	296	117	326	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
TRAM1	Q15629	214	248	117	326	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
TRAM1	Q15629	103	142	117	326	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
SYNPR	Q8TBG9	116	180	1	265	Chain	ID=PRO_0000179157;Note=Synaptoporin
SYNPR	Q8TBG9	116	180	115	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNPR	Q8TBG9	116	180	136	177	Topological domain	Note=Vesicular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNPR	Q8TBG9	116	180	178	198	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNPR	Q8TBG9	116	180	1	202	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
SYVN1	Q86TM6	411	469	23	617	Chain	ID=PRO_0000280548;Note=E3 ubiquitin-protein ligase synoviolin
SYVN1	Q86TM6	253	274	23	617	Chain	ID=PRO_0000280548;Note=E3 ubiquitin-protein ligase synoviolin
SYVN1	Q86TM6	44	75	23	617	Chain	ID=PRO_0000280548;Note=E3 ubiquitin-protein ligase synoviolin
SYVN1	Q86TM6	44	75	42	62	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYVN1	Q86TM6	44	75	63	98	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYVN1	Q86TM6	411	469	246	617	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYVN1	Q86TM6	253	274	246	617	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYVN1	Q86TM6	253	274	236	270	Region	Note=Interaction with p53/TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17170702;Dbxref=PMID:17170702
SYVN1	Q86TM6	411	469	339	478	Compositional bias	Note=Pro-rich
SYVN1	Q86TM6	411	469	411	411	Alternative sequence	ID=VSP_023778;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11347906,ECO:0000303|PubMed:12459480,ECO:0000303|PubMed:14593114,ECO:0000303|PubMed:17974005;Dbxref=PMID:11347906,PMID:12459480,PMID:14593114,PMID:17974005
WARS2	Q9UGM6	30	116	19	360	Chain	ID=PRO_0000035828;Note=Tryptophan--tRNA ligase%2C mitochondrial
WARS2	Q9UGM6	30	116	48	51	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	42	42	Binding site	Note=ATP;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	45	45	Natural variant	ID=VAR_079734;Note=In NEMMLAS. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28905505;Dbxref=PMID:28905505
WARS2	Q9UGM6	30	116	50	50	Natural variant	ID=VAR_028848;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11552864,PMID:15489334
WARS2	Q9UGM6	30	116	77	77	Natural variant	ID=VAR_079735;Note=In NEMMLAS%3B unknown pathological significance. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28905505;Dbxref=dbSNP:rs766501807,PMID:28905505
WARS2	Q9UGM6	30	116	100	100	Natural variant	ID=VAR_079736;Note=In NEMMLAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28650581;Dbxref=PMID:28650581
WARS2	Q9UGM6	30	116	37	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	43	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	49	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	56	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	69	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	85	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	109	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	114	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
TMEM106A	Q96A25	143	190	1	262	Chain	ID=PRO_0000242137;Note=Transmembrane protein 106A
TMEM106A	Q96A25	205	222	1	262	Chain	ID=PRO_0000242137;Note=Transmembrane protein 106A
TMEM161A	Q9NX61	267	304	29	479	Chain	ID=PRO_0000288084;Note=Transmembrane protein 161A
TMEM161A	Q9NX61	36	62	29	479	Chain	ID=PRO_0000288084;Note=Transmembrane protein 161A
TMEM161A	Q9NX61	36	62	29	98	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM161A	Q9NX61	267	304	264	284	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM161A	Q9NX61	267	304	285	304	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM161B	Q8NDZ6	220	266	1	487	Chain	ID=PRO_0000288089;Note=Transmembrane protein 161B
TMEM161B	Q8NDZ6	220	266	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM161B	Q8NDZ6	220	266	265	285	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM170B	Q5T4T1	32	89	1	132	Chain	ID=PRO_0000342267;Note=Transmembrane protein 170B
TMEM170B	Q5T4T1	32	89	1	37	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM170B	Q5T4T1	32	89	38	58	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM170B	Q5T4T1	32	89	59	68	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM170B	Q5T4T1	32	89	69	89	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132D	Q14C87	323	371	31	1099	Chain	ID=PRO_0000287100;Note=Transmembrane protein 132D
TMEM132D	Q14C87	323	371	31	915	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132D	Q14C87	323	371	1	462	Alternative sequence	ID=VSP_025307;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11853319;Dbxref=PMID:11853319
TMEM150A	Q86TG1	22	37	1	271	Chain	ID=PRO_0000274775;Note=Transmembrane protein 150A
TMEM150A	Q86TG1	22	37	1	271	Chain	ID=PRO_0000274775;Note=Transmembrane protein 150A
TMEM150A	Q86TG1	22	37	3	23	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM150A	Q86TG1	22	37	3	23	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM150A	Q86TG1	22	37	24	75	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM150A	Q86TG1	22	37	24	75	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM150A	Q86TG1	22	37	37	37	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM150A	Q86TG1	22	37	37	37	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM150A	Q86TG1	22	37	1	60	Alternative sequence	ID=VSP_022874;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM150A	Q86TG1	22	37	1	60	Alternative sequence	ID=VSP_022874;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GTF2E2	P29084	122	183	1	291	Chain	ID=PRO_0000211226;Note=Transcription initiation factor IIE subunit beta
GTF2E2	P29084	86	122	1	291	Chain	ID=PRO_0000211226;Note=Transcription initiation factor IIE subunit beta
GTF2E2	P29084	122	183	66	146	DNA binding	Note=TFIIE beta;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00682
GTF2E2	P29084	86	122	66	146	DNA binding	Note=TFIIE beta;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00682
GTF2E2	P29084	122	183	133	133	Natural variant	ID=VAR_052281;Note=I->T;Dbxref=dbSNP:rs2229299
GTF2E2	P29084	122	183	150	150	Natural variant	ID=VAR_076893;Note=In TTD6%3B reduction in the levels of both TFIIE-alpha and TFIIE-beta subunits of the TFIIE complex in patient cells%3B reduced phosphorylation of TFIIE-alpha observed in patient cells. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26996949;Dbxref=dbSNP:rs875989846,PMID:26996949
GTF2E2	P29084	122	183	183	183	Natural variant	ID=VAR_039003;Note=K->R;Dbxref=dbSNP:rs2978277
GTF2E2	P29084	86	122	75	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	86	122	99	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	86	122	109	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8K
GTF2E2	P29084	86	122	113	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	122	183	123	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	122	183	130	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	122	183	134	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	122	183	142	144	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D8J
GTF2E2	P29084	122	183	148	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GPY
GTF2E2	P29084	122	183	168	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GPY
GTF2E2	P29084	122	183	178	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GPY
GTF2F2	P13984	162	210	2	249	Chain	ID=PRO_0000211235;Note=General transcription factor IIF subunit 2
GTF2F2	P13984	162	210	177	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BBY
GTF2F2	P13984	162	210	199	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BBY
GTF2F2	P13984	162	210	210	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BBY
L3HYPDH	Q96EM0	226	267	1	354	Chain	ID=PRO_0000288949;Note=Trans-3-hydroxy-L-proline dehydratase
TRAF3IP3	Q9Y228	234	258	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	396	417	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	417	437	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	483	521	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	234	258	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	396	417	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	417	437	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	483	521	1	551	Chain	ID=PRO_0000072403;Note=TRAF3-interacting JNK-activating modulator
TRAF3IP3	Q9Y228	234	258	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	396	417	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	417	437	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	483	521	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	234	258	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	396	417	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	417	437	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	483	521	1	526	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	234	258	240	436	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	396	417	240	436	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	417	437	240	436	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	234	258	240	436	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	396	417	240	436	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	417	437	240	436	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	483	521	464	506	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	483	521	464	506	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3IP3	Q9Y228	396	417	354	551	Alternative sequence	ID=VSP_017273;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAF3IP3	Q9Y228	417	437	354	551	Alternative sequence	ID=VSP_017273;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAF3IP3	Q9Y228	483	521	354	551	Alternative sequence	ID=VSP_017273;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAF3IP3	Q9Y228	396	417	354	551	Alternative sequence	ID=VSP_017273;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAF3IP3	Q9Y228	417	437	354	551	Alternative sequence	ID=VSP_017273;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAF3IP3	Q9Y228	483	521	354	551	Alternative sequence	ID=VSP_017273;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TADA3	O75528	307	368	1	432	Chain	ID=PRO_0000072416;Note=Transcriptional adapter 3
TADA3	O75528	307	368	1	432	Chain	ID=PRO_0000072416;Note=Transcriptional adapter 3
TADA3	O75528	307	368	367	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TADA3	O75528	307	368	367	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF1C	Q15572	520	566	1	869	Chain	ID=PRO_0000118863;Note=TATA box-binding protein-associated factor RNA polymerase I subunit C
TAF1C	Q15572	345	368	1	869	Chain	ID=PRO_0000118863;Note=TATA box-binding protein-associated factor RNA polymerase I subunit C
TAF1C	Q15572	345	368	1	409	Alternative sequence	ID=VSP_038086;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAF1C	Q15572	520	566	521	521	Alternative sequence	ID=VSP_015156;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TAF1C	Q15572	345	368	357	357	Natural variant	ID=VAR_023246;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs4150147
TAF1C	Q15572	520	566	523	523	Natural variant	ID=VAR_057261;Note=G->R;Dbxref=dbSNP:rs4150167
STK17B	O94768	41	111	1	372	Chain	ID=PRO_0000086706;Note=Serine/threonine-protein kinase 17B
STK17B	O94768	41	111	1	372	Chain	ID=PRO_0000086706;Note=Serine/threonine-protein kinase 17B
STK17B	O94768	41	111	33	293	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK17B	O94768	41	111	33	293	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK17B	O94768	41	111	39	47	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK17B	O94768	41	111	39	47	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK17B	O94768	41	111	62	62	Binding site	Note=ATP
STK17B	O94768	41	111	62	62	Binding site	Note=ATP
STK17B	O94768	41	111	62	62	Mutagenesis	Note=Loss of activity and of apoptotic function. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786912;Dbxref=PMID:9786912
STK17B	O94768	41	111	62	62	Mutagenesis	Note=Loss of activity and of apoptotic function. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786912;Dbxref=PMID:9786912
STK17B	O94768	41	111	32	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	32	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	45	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	45	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	58	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	58	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	74	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	74	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	96	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	96	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	103	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STK17B	O94768	41	111	103	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5
STEAP1B	Q6NZ63	28	180	1	245	Chain	ID=PRO_0000321512;Note=STEAP family member 1B
STEAP1B	Q6NZ63	28	180	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP1B	Q6NZ63	28	180	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP1B	Q6NZ63	28	180	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP1B	Q6NZ63	28	180	28	28	Alternative sequence	ID=VSP_054116;Note=In isoform 2. L->LHEDTGETSMLKRPVLLHLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STEAP1B	Q6NZ63	28	180	29	29	Natural variant	ID=VAR_039340;Note=Q->R;Dbxref=dbSNP:rs16881810
STEAP1B	Q6NZ63	28	180	166	166	Natural variant	ID=VAR_039341;Note=R->M;Dbxref=dbSNP:rs16881812
STK16	O75716	187	219	2	305	Chain	ID=PRO_0000086701;Note=Serine/threonine-protein kinase 16
STK16	O75716	187	219	2	305	Chain	ID=PRO_0000086701;Note=Serine/threonine-protein kinase 16
STK16	O75716	187	219	20	293	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK16	O75716	187	219	20	293	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK16	O75716	187	219	166	202	Region	Note=Activation loop
STK16	O75716	187	219	166	202	Region	Note=Activation loop
STK16	O75716	187	219	197	197	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184589;Dbxref=PMID:18184589
STK16	O75716	187	219	197	197	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184589;Dbxref=PMID:18184589
STK16	O75716	187	219	198	198	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184589;Dbxref=PMID:18184589
STK16	O75716	187	219	198	198	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18184589;Dbxref=PMID:18184589
STK16	O75716	187	219	213	213	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK16	O75716	187	219	213	213	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK16	O75716	187	219	213	213	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK16	O75716	187	219	213	213	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK16	O75716	187	219	180	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	180	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	208	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	208	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	215	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STK16	O75716	187	219	215	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BUJ
STOX2	Q9P2F5	55	106	1	926	Chain	ID=PRO_0000313629;Note=Storkhead-box protein 2
STMN4	Q9H169	106	170	1	189	Chain	ID=PRO_0000182406;Note=Stathmin-4
STMN4	Q9H169	4	36	1	189	Chain	ID=PRO_0000182406;Note=Stathmin-4
STMN4	Q9H169	106	170	48	189	Domain	Note=SLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00998
STMN4	Q9H169	106	170	90	188	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STMN4	Q9H169	4	36	20	20	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q93045
STMN4	Q9H169	4	36	22	22	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q93045
STMN4	Q9H169	4	36	1	9	Alternative sequence	ID=VSP_055279;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STMN4	Q9H169	4	36	36	36	Alternative sequence	ID=VSP_006279;Note=In isoform 2 and isoform 4. E->EGWCGRQCRRKDESQRKDSADWRERRAQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
STMN4	Q9H169	4	36	11	11	Sequence conflict	Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
STMN4	Q9H169	106	170	91	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BR1
STRN4	Q9NRL3	668	697	1	753	Chain	ID=PRO_0000051239;Note=Striatin-4
STRN4	Q9NRL3	588	635	1	753	Chain	ID=PRO_0000051239;Note=Striatin-4
STRN4	Q9NRL3	531	588	1	753	Chain	ID=PRO_0000051239;Note=Striatin-4
STRN4	Q9NRL3	475	490	1	753	Chain	ID=PRO_0000051239;Note=Striatin-4
STRN4	Q9NRL3	180	245	1	753	Chain	ID=PRO_0000051239;Note=Striatin-4
STRN4	Q9NRL3	475	490	436	475	Repeat	Note=WD 1
STRN4	Q9NRL3	475	490	489	528	Repeat	Note=WD 2
STRN4	Q9NRL3	531	588	542	581	Repeat	Note=WD 3
STRN4	Q9NRL3	588	635	587	628	Repeat	Note=WD 4
STRN4	Q9NRL3	531	588	587	628	Repeat	Note=WD 4
STRN4	Q9NRL3	668	697	635	674	Repeat	Note=WD 5
STRN4	Q9NRL3	588	635	635	674	Repeat	Note=WD 5
STRN4	Q9NRL3	668	697	677	716	Repeat	Note=WD 6
STRN4	Q9NRL3	180	245	165	182	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
STRN4	Q9NRL3	180	245	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
STRN4	Q9NRL3	668	697	377	753	Alternative sequence	ID=VSP_056172;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STRN4	Q9NRL3	588	635	377	753	Alternative sequence	ID=VSP_056172;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STRN4	Q9NRL3	531	588	377	753	Alternative sequence	ID=VSP_056172;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STRN4	Q9NRL3	475	490	377	753	Alternative sequence	ID=VSP_056172;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STRN4	Q9NRL3	531	588	568	568	Natural variant	ID=VAR_053419;Note=V->I;Dbxref=dbSNP:rs10409124
STPG1	Q5TH74	63	97	1	334	Chain	ID=PRO_0000305170;Note=O(6)-methylguanine-induced apoptosis 2
STPG1	Q5TH74	63	97	1	334	Chain	ID=PRO_0000305170;Note=O(6)-methylguanine-induced apoptosis 2
STPG1	Q5TH74	63	97	67	74	Repeat	Note=STPGR 1
STPG1	Q5TH74	63	97	67	74	Repeat	Note=STPGR 1
STPG1	Q5TH74	63	97	72	72	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
STPG1	Q5TH74	63	97	72	72	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
STPG1	Q5TH74	63	97	1	92	Alternative sequence	ID=VSP_028252;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STPG1	Q5TH74	63	97	1	92	Alternative sequence	ID=VSP_028252;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STPG1	Q5TH74	63	97	93	93	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
STPG1	Q5TH74	63	97	93	93	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
STRIP1	Q5VSL9	194	216	1	837	Chain	ID=PRO_0000187017;Note=Striatin-interacting protein 1
STRIP1	Q5VSL9	472	496	1	837	Chain	ID=PRO_0000187017;Note=Striatin-interacting protein 1
STRIP1	Q5VSL9	496	521	1	837	Chain	ID=PRO_0000187017;Note=Striatin-interacting protein 1
STRIP1	Q5VSL9	194	216	1	264	Alternative sequence	ID=VSP_014856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STRIP1	Q5VSL9	194	216	194	212	Alternative sequence	ID=VSP_014858;Note=In isoform 4. DNSAACSSAVRKPAISLAD->EHCCVRPAVSALAGGQAQD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STRIP1	Q5VSL9	194	216	213	837	Alternative sequence	ID=VSP_014859;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STRIP1	Q5VSL9	472	496	213	837	Alternative sequence	ID=VSP_014859;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STRIP1	Q5VSL9	496	521	213	837	Alternative sequence	ID=VSP_014859;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STRIP2	Q9ULQ0	66	91	1	834	Chain	ID=PRO_0000187022;Note=Striatin-interacting protein 2
STRIP2	Q9ULQ0	425	446	1	834	Chain	ID=PRO_0000187022;Note=Striatin-interacting protein 2
STX4	Q12846	77	102	1	297	Chain	ID=PRO_0000210202;Note=Syntaxin-4
STX4	Q12846	77	102	1	275	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX4	Q12846	77	102	43	163	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SI	P14410	340	382	2	1827	Chain	ID=PRO_0000018551;Note=Sucrase-isomaltase%2C intestinal
SI	P14410	340	382	2	1007	Chain	ID=PRO_0000018552;Note=Isomaltase
SI	P14410	340	382	33	1827	Topological domain	Note=Lumenal
SI	P14410	340	382	110	1007	Region	Note=Isomaltase
SI	P14410	340	382	341	341	Natural variant	ID=VAR_025370;Note=In CSID%3B causes loss of anchored SI from the membrane. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10903344;Dbxref=dbSNP:rs267607049,PMID:10903344
SI	P14410	340	382	331	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LPP
SI	P14410	340	382	350	353	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LPP
SI	P14410	340	382	365	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LPP
SUN5	Q8TC36	45	70	1	379	Chain	ID=PRO_0000218919;Note=SUN domain-containing protein 5
SUN5	Q8TC36	45	70	1	105	Topological domain	Note=Nuclear;Ontology_term=ECO:0000255;evidence=ECO:0000255
SUN2	Q9UH99	649	680	1	717	Chain	ID=PRO_0000218913;Note=SUN domain-containing protein 2
SUN2	Q9UH99	452	526	1	717	Chain	ID=PRO_0000218913;Note=SUN domain-containing protein 2
SUN2	Q9UH99	95	141	1	717	Chain	ID=PRO_0000218913;Note=SUN domain-containing protein 2
SUN2	Q9UH99	649	680	1	717	Chain	ID=PRO_0000218913;Note=SUN domain-containing protein 2
SUN2	Q9UH99	452	526	1	717	Chain	ID=PRO_0000218913;Note=SUN domain-containing protein 2
SUN2	Q9UH99	95	141	1	717	Chain	ID=PRO_0000218913;Note=SUN domain-containing protein 2
SUN2	Q9UH99	95	141	1	212	Topological domain	Note=Nuclear;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709
SUN2	Q9UH99	95	141	1	212	Topological domain	Note=Nuclear;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709
SUN2	Q9UH99	649	680	234	717	Topological domain	Note=Perinuclear space;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709
SUN2	Q9UH99	452	526	234	717	Topological domain	Note=Perinuclear space;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709
SUN2	Q9UH99	649	680	234	717	Topological domain	Note=Perinuclear space;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709
SUN2	Q9UH99	452	526	234	717	Topological domain	Note=Perinuclear space;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709
SUN2	Q9UH99	649	680	555	716	Domain	Note=SUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00802
SUN2	Q9UH99	649	680	555	716	Domain	Note=SUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00802
SUN2	Q9UH99	95	141	1	139	Region	Note=LMNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
SUN2	Q9UH99	95	141	1	139	Region	Note=LMNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
SUN2	Q9UH99	649	680	507	717	Region	Note=Sufficient for interaction with SYNE1 and SYNE2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968
SUN2	Q9UH99	452	526	507	717	Region	Note=Sufficient for interaction with SYNE1 and SYNE2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968
SUN2	Q9UH99	649	680	507	717	Region	Note=Sufficient for interaction with SYNE1 and SYNE2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968
SUN2	Q9UH99	452	526	507	717	Region	Note=Sufficient for interaction with SYNE1 and SYNE2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968
SUN2	Q9UH99	452	526	475	506	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SUN2	Q9UH99	452	526	475	506	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SUN2	Q9UH99	95	141	2	164	Compositional bias	Note=Ser-rich
SUN2	Q9UH99	95	141	2	164	Compositional bias	Note=Ser-rich
SUN2	Q9UH99	95	141	100	105	Compositional bias	Note=Poly-Arg
SUN2	Q9UH99	95	141	100	105	Compositional bias	Note=Poly-Arg
SUN2	Q9UH99	452	526	468	471	Compositional bias	Note=Poly-Gly
SUN2	Q9UH99	452	526	468	471	Compositional bias	Note=Poly-Gly
SUN2	Q9UH99	95	141	107	107	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	107	107	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	113	113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	113	113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12239280;Dbxref=PMID:12239280
SUN2	Q9UH99	95	141	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12239280;Dbxref=PMID:12239280
SUN2	Q9UH99	95	141	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	95	141	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4
SUN2	Q9UH99	649	680	601	705	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22632968,ECO:0000269|PubMed:22945352;Dbxref=PMID:22632968,PMID:22945352
SUN2	Q9UH99	649	680	601	705	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22632968,ECO:0000269|PubMed:22945352;Dbxref=PMID:22632968,PMID:22945352
SUN2	Q9UH99	95	141	141	141	Alternative sequence	ID=VSP_045882;Note=In isoform 2. V->VEDSEGRGSKVTETEPVSSFPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SUN2	Q9UH99	95	141	141	141	Alternative sequence	ID=VSP_045882;Note=In isoform 2. V->VEDSEGRGSKVTETEPVSSFPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SUN2	Q9UH99	649	680	671	671	Natural variant	ID=VAR_024624;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2072797,PMID:15489334
SUN2	Q9UH99	649	680	671	671	Natural variant	ID=VAR_024624;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2072797,PMID:15489334
SUN2	Q9UH99	452	526	525	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	452	526	525	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	649	680	645	655	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	649	680	645	655	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	649	680	660	666	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	649	680	660	666	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	649	680	669	671	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UNP
SUN2	Q9UH99	649	680	669	671	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UNP
SUN2	Q9UH99	649	680	673	678	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUN2	Q9UH99	649	680	673	678	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DXT
SUSD3	Q96L08	142	185	1	255	Chain	ID=PRO_0000251973;Note=Sushi domain-containing protein 3
SUSD3	Q96L08	142	185	125	255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SUSD5	O60279	136	199	36	629	Chain	ID=PRO_0000274247;Note=Sushi domain-containing protein 5
SUSD5	O60279	136	199	36	574	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SUSD5	O60279	136	199	138	199	Domain	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SUSD5	O60279	136	199	140	184	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SUSD5	O60279	136	199	167	197	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SUV39H2	Q9H5I1	59	283	1	410	Chain	ID=PRO_0000186059;Note=Histone-lysine N-methyltransferase SUV39H2
SUV39H2	Q9H5I1	59	283	47	105	Domain	Note=Chromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
SUV39H2	Q9H5I1	59	283	189	247	Domain	Note=Pre-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00157
SUV39H2	Q9H5I1	59	283	250	373	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SUV39H2	Q9H5I1	59	283	261	263	Region	Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	191	191	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	191	191	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	193	193	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	196	196	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	196	196	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	201	201	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	202	202	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	229	229	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	229	229	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	233	233	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	235	235	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	239	239	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2R3A,ECO:0000269|PubMed:20084102;Dbxref=PMID:20084102
SUV39H2	Q9H5I1	59	283	1	60	Alternative sequence	ID=VSP_002209;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
SUV39H2	Q9H5I1	59	283	104	283	Alternative sequence	ID=VSP_002210;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SUV39H2	Q9H5I1	59	283	125	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	150	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	154	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	196	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	202	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	252	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	258	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	263	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	276	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SUV39H2	Q9H5I1	59	283	283	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R3A
SVOPL	Q8N434	421	451	1	492	Chain	ID=PRO_0000294461;Note=Putative transporter SVOPL
SVOPL	Q8N434	91	115	1	492	Chain	ID=PRO_0000294461;Note=Putative transporter SVOPL
SVOPL	Q8N434	91	115	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SVOPL	Q8N434	421	451	429	449	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SVOPL	Q8N434	91	115	1	152	Alternative sequence	ID=VSP_026651;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AARS2	Q5JTZ9	894	931	24	985	Chain	ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial
AARS2	Q5JTZ9	788	829	24	985	Chain	ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial
AARS2	Q5JTZ9	383	396	24	985	Chain	ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial
SYCE2	Q6PIF2	165	204	1	218	Chain	ID=PRO_0000262562;Note=Synaptonemal complex central element protein 2
TPGS2	Q68CL5	84	122	1	300	Chain	ID=PRO_0000079304;Note=Tubulin polyglutamylase complex subunit 2
TPGS2	Q68CL5	84	122	85	127	Alternative sequence	ID=VSP_020113;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15221005,ECO:0000303|PubMed:15489334;Dbxref=PMID:15221005,PMID:15489334
TPGS2	Q68CL5	84	122	85	119	Alternative sequence	ID=VSP_054525;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EARS2	Q5JPH6	46	98	42	523	Chain	ID=PRO_0000254560;Note=Probable glutamate--tRNA ligase%2C mitochondrial
EARS2	Q5JPH6	46	98	45	53	Motif	Note="HIGH" region
EARS2	Q5JPH6	46	98	50	50	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EARS2	Q5JPH6	46	98	76	76	Binding site	Note=Glutamate;Ontology_term=ECO:0000250;evidence=ECO:0000250
EARS2	Q5JPH6	46	98	55	55	Natural variant	ID=VAR_069235;Note=In COXPD12. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22492562;Dbxref=dbSNP:rs770862902,PMID:22492562
EARS2	Q5JPH6	46	98	65	65	Natural variant	ID=VAR_069236;Note=In COXPD12. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23008233;Dbxref=dbSNP:rs397514595,PMID:23008233
EARS2	Q5JPH6	46	98	96	96	Natural variant	ID=VAR_069237;Note=In COXPD12. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22492562;Dbxref=dbSNP:rs397514593,PMID:22492562
SULT1A1	P50225	49	91	1	295	Chain	ID=PRO_0000085127;Note=Sulfotransferase 1A1
SULT1A1	P50225	49	91	1	295	Chain	ID=PRO_0000085127;Note=Sulfotransferase 1A1
SULT1A1	P50225	49	91	1	295	Chain	ID=PRO_0000085127;Note=Sulfotransferase 1A1
SULT1A1	P50225	49	91	1	295	Chain	ID=PRO_0000085127;Note=Sulfotransferase 1A1
SULT1A1	P50225	49	91	48	53	Nucleotide binding	Note=PAPS
SULT1A1	P50225	49	91	48	53	Nucleotide binding	Note=PAPS
SULT1A1	P50225	49	91	48	53	Nucleotide binding	Note=PAPS
SULT1A1	P50225	49	91	48	53	Nucleotide binding	Note=PAPS
SULT1A1	P50225	49	91	1	124	Alternative sequence	ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.14
SULT1A1	P50225	49	91	1	124	Alternative sequence	ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.14
SULT1A1	P50225	49	91	1	124	Alternative sequence	ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.14
SULT1A1	P50225	49	91	1	124	Alternative sequence	ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.14
SULT1A1	P50225	49	91	70	70	Mutagenesis	Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270
SULT1A1	P50225	49	91	70	70	Mutagenesis	Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270
SULT1A1	P50225	49	91	70	70	Mutagenesis	Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270
SULT1A1	P50225	49	91	70	70	Mutagenesis	Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270
SULT1A1	P50225	49	91	90	90	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SULT1A1	P50225	49	91	90	90	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SULT1A1	P50225	49	91	90	90	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SULT1A1	P50225	49	91	90	90	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SULT1A1	P50225	49	91	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	67	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	67	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	67	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	67	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6
SULT1A1	P50225	49	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA
SULT1A1	P50225	49	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA
SULT1A1	P50225	49	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA
SULT1A1	P50225	49	91	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA
STAP2	Q9UGK3	357	382	1	403	Chain	ID=PRO_0000072239;Note=Signal-transducing adaptor protein 2
STAP2	Q9UGK3	276	326	1	403	Chain	ID=PRO_0000072239;Note=Signal-transducing adaptor protein 2
STAP2	Q9UGK3	254	276	1	403	Chain	ID=PRO_0000072239;Note=Signal-transducing adaptor protein 2
STAP2	Q9UGK3	152	196	1	403	Chain	ID=PRO_0000072239;Note=Signal-transducing adaptor protein 2
STAP2	Q9UGK3	34	58	1	403	Chain	ID=PRO_0000072239;Note=Signal-transducing adaptor protein 2
STAP2	Q9UGK3	34	58	18	130	Domain	Note=PH
STAP2	Q9UGK3	152	196	133	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAP2	Q9UGK3	357	382	382	402	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STAP2	Q9UGK3	357	382	271	359	Compositional bias	Note=Pro-rich
STAP2	Q9UGK3	276	326	271	359	Compositional bias	Note=Pro-rich
STAP2	Q9UGK3	254	276	271	359	Compositional bias	Note=Pro-rich
STAP2	Q9UGK3	276	326	310	310	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12540842;Dbxref=PMID:12540842
STAP2	Q9UGK3	276	326	322	322	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12540842;Dbxref=PMID:12540842
STAP2	Q9UGK3	276	326	310	310	Mutagenesis	Note=Decrease in tyrosine phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12540842;Dbxref=PMID:12540842
STAP2	Q9UGK3	276	326	322	322	Mutagenesis	Note=Decrease in tyrosine phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12540842;Dbxref=PMID:12540842
STAP2	Q9UGK3	152	196	159	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EL8
STAP2	Q9UGK3	152	196	174	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EL8
STAP2	Q9UGK3	152	196	182	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EL8
STX3	Q13277	71	96	1	289	Chain	ID=PRO_0000210199;Note=Syntaxin-3
STX3	Q13277	225	262	1	289	Chain	ID=PRO_0000210199;Note=Syntaxin-3
STX3	Q13277	71	96	1	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX3	Q13277	225	262	1	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX3	Q13277	225	262	191	253	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
STX3	Q13277	71	96	32	111	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STX3	Q13277	225	262	226	262	Alternative sequence	ID=VSP_006340;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10080545;Dbxref=PMID:10080545
STX3	Q13277	71	96	83	83	Natural variant	ID=VAR_028189;Note=E->D;Dbxref=dbSNP:rs12282741
STX3	Q13277	71	96	81	81	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STX3	Q13277	225	262	250	250	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STX3	Q13277	225	262	250	250	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP1	P61764	265	300	1	594	Chain	ID=PRO_0000206277;Note=Syntaxin-binding protein 1
STXBP1	P61764	343	370	1	594	Chain	ID=PRO_0000206277;Note=Syntaxin-binding protein 1
STXBP1	P61764	265	300	122	594	Natural variant	ID=VAR_078757;Note=In EIEE4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25818041;Dbxref=PMID:25818041
STXBP1	P61764	343	370	122	594	Natural variant	ID=VAR_078757;Note=In EIEE4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25818041;Dbxref=PMID:25818041
STXBP1	P61764	265	300	281	281	Natural variant	ID=VAR_078758;Note=In EIEE4. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
STXBP1	P61764	265	300	283	283	Natural variant	ID=VAR_071814;Note=In EIEE4. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24623842;Dbxref=dbSNP:rs587777310,PMID:24623842
STXBP1	P61764	265	300	285	285	Natural variant	ID=VAR_071815;Note=In EIEE4. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24623842;Dbxref=PMID:24623842
STXBP1	P61764	265	300	292	292	Natural variant	ID=VAR_078759;Note=In EIEE4. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=dbSNP:rs796053361,PMID:26993267
STXBP1	P61764	343	370	354	354	Natural variant	ID=VAR_078634;Note=In EIEE4. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=dbSNP:rs886041337,PMID:23708187
STYX	Q8WUJ0	19	30	1	223	Chain	ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein
STYX	Q8WUJ0	30	48	1	223	Chain	ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein
STYX	Q8WUJ0	127	143	1	223	Chain	ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein
STYX	Q8WUJ0	19	30	1	223	Chain	ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein
STYX	Q8WUJ0	30	48	1	223	Chain	ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein
STYX	Q8WUJ0	127	143	1	223	Chain	ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein
STYX	Q8WUJ0	127	143	96	167	Domain	Note=Tyrosine-protein phosphatase
STYX	Q8WUJ0	127	143	96	167	Domain	Note=Tyrosine-protein phosphatase
STYX	Q8WUJ0	127	143	142	144	Mutagenesis	Note=Increases interaction with FBXW7. KYR->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28007894;Dbxref=PMID:28007894
STYX	Q8WUJ0	127	143	142	144	Mutagenesis	Note=Increases interaction with FBXW7. KYR->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28007894;Dbxref=PMID:28007894
STYX	Q8WUJ0	19	30	30	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	30	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	19	30	30	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	30	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	46	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	30	48	46	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	127	143	126	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	127	143	126	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	127	143	143	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
STYX	Q8WUJ0	127	143	143	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B
SUCLG2	Q96I99	252	306	38	432	Chain	ID=PRO_0000033356;Note=Succinate--CoA ligase [GDP-forming] subunit beta%2C mitochondrial
SUCLG2	Q96I99	252	306	46	274	Domain	Note=ATP-grasp;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03221
SUCLG2	Q96I99	252	306	257	257	Metal binding	Note=Magnesium;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03221
SUCLG2	Q96I99	252	306	271	271	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2I8
SUCLG2	Q96I99	252	306	291	291	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TRAPPC6A	O75865	90	118	1	159	Chain	ID=PRO_0000244539;Note=Trafficking protein particle complex subunit 6A
TRAPPC6A	O75865	90	118	29	159	Alternative sequence	ID=VSP_047016;Note=In isoform 3. GQKMSLSVLEGMGFRVGQALGERLPRETLAFREELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPLLLPMASGLQYLEEAPKFLAFTCGLLRGALYTLGIESVVTASVAALPVCKFQVVIPKS->AAPGDAGLQGGAGCPQVLVQRPVGGGVPEADGQPAHQSPGDLRPARQQLPPPPPDGLWPAVSGGSTQVPGLHLRPPARRPLYPGH;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAPPC6A	O75865	90	118	29	159	Alternative sequence	ID=VSP_047017;Note=In isoform 4. GQKMSLSVLEGMGFRVGQALGERLPRETLAFREELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPLLLPMASGLQYLEEAPKFLAFTCGLLRGALYTLGIESVVTASVAALPVCKFQVVIPKS->VSAGLRGEEAGATKAAPGDAGLQGGAGCPQVLVQRPVGGGVPEADGQPAHQSPGDLRPARQQLPPPPPDGLWPAVSGGSTQVPGLHLRPPARRPLYPGH;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAPPC6A	O75865	90	118	99	123	Sequence conflict	Note=SFPLLLPMASGLQYLEEAPKFLAFT->KLSPPPPDGLWPAVSGGSTQVPGLH;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAPPC6A	O75865	90	118	89	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0J
TRAPPC6A	O75865	90	118	101	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0J
TRAPPC6A	O75865	90	118	110	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0J
TRAPPC6A	O75865	90	118	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0J
TRAPPC6A	O75865	90	118	116	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0J
FARSA	Q9Y285	398	424	2	508	Chain	ID=PRO_0000126824;Note=Phenylalanine--tRNA ligase alpha subunit
FARSA	Q9Y285	168	198	2	508	Chain	ID=PRO_0000126824;Note=Phenylalanine--tRNA ligase alpha subunit
FARSA	Q9Y285	95	128	2	508	Chain	ID=PRO_0000126824;Note=Phenylalanine--tRNA ligase alpha subunit
FARSA	Q9Y285	168	198	190	190	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FARSA	Q9Y285	168	198	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
FARSA	Q9Y285	168	198	169	199	Alternative sequence	ID=VSP_056196;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FARSA	Q9Y285	168	198	179	179	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FARSA	Q9Y285	95	128	98	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	112	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	168	198	167	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	168	198	194	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	398	424	397	399	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	398	424	404	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	398	424	414	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
TNFRSF10A	O00220	234	266	24	468	Chain	ID=PRO_0000034579;Note=Tumor necrosis factor receptor superfamily member 10A
TNFRSF10A	O00220	234	266	24	239	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF10A	O00220	234	266	240	262	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF10A	O00220	234	266	263	468	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM74	Q86UV6	133	165	1	250	Chain	ID=PRO_0000056279;Note=Tripartite motif-containing protein 74
TRIM74	Q86UV6	133	165	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM74	Q86UV6	133	165	159	159	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIO	O75962	456	500	1	3097	Chain	ID=PRO_0000080978;Note=Triple functional domain protein
TRIO	O75962	577	618	1	3097	Chain	ID=PRO_0000080978;Note=Triple functional domain protein
TRIO	O75962	1889	1921	1	3097	Chain	ID=PRO_0000080978;Note=Triple functional domain protein
TRIO	O75962	2051	2081	1	3097	Chain	ID=PRO_0000080978;Note=Triple functional domain protein
TRIO	O75962	2129	2155	1	3097	Chain	ID=PRO_0000080978;Note=Triple functional domain protein
TRIO	O75962	2804	2870	1	3097	Chain	ID=PRO_0000080978;Note=Triple functional domain protein
TRIO	O75962	577	618	538	644	Repeat	Note=Spectrin 2
TRIO	O75962	2051	2081	1969	2145	Domain	Note=DH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
TRIO	O75962	2129	2155	1969	2145	Domain	Note=DH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
TRIO	O75962	2804	2870	2796	3052	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TRIO	O75962	2804	2870	2802	2810	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TRIO	O75962	2804	2870	2825	2825	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TRIO	O75962	456	500	1	2501	Alternative sequence	ID=VSP_023306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRIO	O75962	577	618	1	2501	Alternative sequence	ID=VSP_023306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRIO	O75962	1889	1921	1	2501	Alternative sequence	ID=VSP_023306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRIO	O75962	2051	2081	1	2501	Alternative sequence	ID=VSP_023306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRIO	O75962	2129	2155	1	2501	Alternative sequence	ID=VSP_023306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRIO	O75962	2804	2870	2564	3097	Alternative sequence	ID=VSP_037862;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
TRIP12	Q14669	1823	1861	2	1992	Chain	ID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
TRIP12	Q14669	1768	1823	2	1992	Chain	ID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
TRIP12	Q14669	1713	1768	2	1992	Chain	ID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
TRIP12	Q14669	1133	1197	2	1992	Chain	ID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
TRIP12	Q14669	560	614	2	1992	Chain	ID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
TRIP12	Q14669	381	403	2	1992	Chain	ID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
TRIP12	Q14669	1823	1861	338	1992	Natural variant	ID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1768	1823	338	1992	Natural variant	ID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1713	1768	338	1992	Natural variant	ID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1133	1197	338	1992	Natural variant	ID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	560	614	338	1992	Natural variant	ID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	381	403	338	1992	Natural variant	ID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1823	1861	352	1992	Natural variant	ID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1768	1823	352	1992	Natural variant	ID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1713	1768	352	1992	Natural variant	ID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1133	1197	352	1992	Natural variant	ID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	560	614	352	1992	Natural variant	ID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	381	403	352	1992	Natural variant	ID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRIP12	Q14669	1823	1861	1449	1992	Natural variant	ID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
TRIP12	Q14669	1768	1823	1449	1992	Natural variant	ID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
TRIP12	Q14669	1713	1768	1449	1992	Natural variant	ID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
TRIP12	Q14669	1823	1861	1840	1840	Natural variant	ID=VAR_080438;Note=In MRD49. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
TRMT11	Q7Z4G4	226	253	2	463	Chain	ID=PRO_0000230288;Note=tRNA (guanine(10)-N2)-methyltransferase homolog
TRMT11	Q7Z4G4	226	253	230	230	Natural variant	ID=VAR_025786;Note=L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854915,PMID:15489334
TRMT1L	Q7Z2T5	586	607	1	733	Chain	ID=PRO_0000317568;Note=TRMT1-like protein
TRMT1L	Q7Z2T5	370	440	1	733	Chain	ID=PRO_0000317568;Note=TRMT1-like protein
TRMT1L	Q7Z2T5	78	115	1	733	Chain	ID=PRO_0000317568;Note=TRMT1-like protein
TRMT1L	Q7Z2T5	586	607	227	688	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1L	Q7Z2T5	370	440	227	688	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1L	Q7Z2T5	78	115	1	156	Alternative sequence	ID=VSP_031042;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRMT1L	Q7Z2T5	586	607	505	733	Alternative sequence	ID=VSP_031043;Note=In isoform 2. ENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW->DYSANFVISYTGFPFVNRQDIRKTHIDSCLVTVMEACLERQQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TARS2	Q9BW92	258	307	211	340	Alternative sequence	ID=VSP_054537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TARS2	Q9BW92	307	340	211	340	Alternative sequence	ID=VSP_054537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TARS2	Q9BW92	258	307	282	282	Natural variant	ID=VAR_071853;Note=In COXPD21%3B decreased expression at mRNA and protein levels%3B decreased threonine-tRNA ligase activity%3B affects both Thr activation and transfer%3B decreased aminoacyl-tRNA editing activity%3B decreased protein stability%3B loss of homodimerization. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24827421,ECO:0000269|PubMed:26811336;Dbxref=dbSNP:rs587777593,PMID:24827421,PMID:26811336
TARS2	Q9BW92	258	307	269	269	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TARS2	Q9BW92	573	606	579	579	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FTSJ1	Q9UET6	190	218	1	329	Chain	ID=PRO_0000155575;Note=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
FTSJ1	Q9UET6	253	319	1	329	Chain	ID=PRO_0000155575;Note=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
FTSJ1	Q9UET6	253	319	271	271	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YARS	P54577	197	228	1	528	Chain	ID=PRO_0000423285;Note=Tyrosine--tRNA ligase%2C cytoplasmic
YARS	P54577	170	197	1	528	Chain	ID=PRO_0000423285;Note=Tyrosine--tRNA ligase%2C cytoplasmic
YARS	P54577	19	68	1	528	Chain	ID=PRO_0000423285;Note=Tyrosine--tRNA ligase%2C cytoplasmic
YARS	P54577	197	228	2	528	Chain	ID=PRO_0000055673;Note=Tyrosine--tRNA ligase%2C cytoplasmic%2C N-terminally processed
YARS	P54577	170	197	2	528	Chain	ID=PRO_0000055673;Note=Tyrosine--tRNA ligase%2C cytoplasmic%2C N-terminally processed
YARS	P54577	19	68	2	528	Chain	ID=PRO_0000055673;Note=Tyrosine--tRNA ligase%2C cytoplasmic%2C N-terminally processed
YARS	P54577	19	68	44	52	Motif	Note="HIGH" region
YARS	P54577	197	228	222	226	Motif	Note="KMSKS" region
YARS	P54577	19	68	39	39	Binding site	Note=Tyrosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4QBT,ECO:0000269|PubMed:14671330;Dbxref=PMID:14671330
YARS	P54577	170	197	170	170	Binding site	Note=Tyrosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4QBT,ECO:0000269|PubMed:14671330;Dbxref=PMID:14671330
YARS	P54577	170	197	173	173	Binding site	Note=Tyrosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4QBT,ECO:0000269|PubMed:14671330;Dbxref=PMID:14671330
YARS	P54577	170	197	188	188	Binding site	Note=Tyrosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4QBT,ECO:0000269|PubMed:14671330;Dbxref=PMID:14671330
YARS	P54577	197	228	197	197	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
YARS	P54577	170	197	197	197	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
YARS	P54577	197	228	205	205	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YARS	P54577	197	228	206	206	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
YARS	P54577	19	68	41	41	Natural variant	ID=VAR_026681;Note=In CMTDIC%3B partial loss of activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16429158;Dbxref=dbSNP:rs121908833,PMID:16429158
YARS	P54577	170	197	170	170	Natural variant	ID=VAR_026683;Note=Q->H;Dbxref=dbSNP:rs2128600
YARS	P54577	170	197	196	196	Natural variant	ID=VAR_026684;Note=In CMTDIC%3B partial loss of activity. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16429158;Dbxref=dbSNP:rs121908834,PMID:16429158
YARS	P54577	19	68	19	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	19	68	24	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	19	68	37	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	19	68	50	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	19	68	53	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	19	68	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	170	197	161	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	170	197	180	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	170	197	186	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	197	228	189	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	170	197	189	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	197	228	199	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS	P54577	197	228	208	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N3L
YARS2	Q9Y2Z4	368	424	17	477	Chain	ID=PRO_0000035830;Note=Tyrosine--tRNA ligase%2C mitochondrial
YARS2	Q9Y2Z4	260	315	17	477	Chain	ID=PRO_0000035830;Note=Tyrosine--tRNA ligase%2C mitochondrial
YARS2	Q9Y2Z4	260	315	281	285	Motif	Note="KMSKS" region;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	260	315	274	274	Binding site	Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2PID,ECO:0000244|PDB:3ZXI,ECO:0000269|PubMed:17997975;Dbxref=PMID:17997975
YARS2	Q9Y2Z4	260	315	284	284	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
YARS2	Q9Y2Z4	260	315	272	272	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	260	315	311	311	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	260	315	248	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	267	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	291	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	294	296	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	299	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	311	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	368	424	344	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
TMEM132E	Q6IEE7	569	633	26	984	Chain	ID=PRO_0000287103;Note=Transmembrane protein 132E
TMEM132E	Q6IEE7	569	633	26	803	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	133	171	26	297	Chain	ID=PRO_0000287280;Note=Transmembrane protein 178A
TMEM178A	Q8NBL3	171	217	26	297	Chain	ID=PRO_0000287280;Note=Transmembrane protein 178A
TMEM178A	Q8NBL3	133	171	26	179	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	171	217	26	179	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	171	217	180	200	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	171	217	201	208	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	171	217	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	133	171	158	158	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178A	Q8NBL3	133	171	112	297	Alternative sequence	ID=VSP_025429;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
TMEM178A	Q8NBL3	171	217	112	297	Alternative sequence	ID=VSP_025429;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
TMEM150C	B9EJG8	27	44	1	249	Chain	ID=PRO_0000395032;Note=Transmembrane protein 150C
TMEM150C	B9EJG8	27	44	1	249	Chain	ID=PRO_0000395032;Note=Transmembrane protein 150C
TMEM150C	B9EJG8	27	44	10	30	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM150C	B9EJG8	27	44	10	30	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM150C	B9EJG8	27	44	31	64	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM150C	B9EJG8	27	44	31	64	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
GTF2A2	P52657	24	59	1	109	Chain	ID=PRO_0000194042;Note=Transcription initiation factor IIA subunit 2
GTF2A2	P52657	24	59	1	109	Chain	ID=PRO_0000194042;Note=Transcription initiation factor IIA subunit 2
GTF2A2	P52657	24	59	1	109	Chain	ID=PRO_0000194042;Note=Transcription initiation factor IIA subunit 2
GTF2A2	P52657	24	59	10	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	10	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	10	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	30	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	30	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	30	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	55	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	55	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A2	P52657	24	59	55	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2F1	P35269	109	165	2	517	Chain	ID=PRO_0000211231;Note=General transcription factor IIF subunit 1
GTF2F1	P35269	109	165	156	156	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
GTF2F1	P35269	109	165	109	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F3U
GTF2F1	P35269	109	165	120	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F3U
GTF2F1	P35269	109	165	135	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F3U
GTF2F1	P35269	109	165	149	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F3U
GTF2F1	P35269	109	165	157	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F3U
TM4SF5	O14894	59	86	1	197	Chain	ID=PRO_0000219303;Note=Transmembrane 4 L6 family member 5
TM4SF5	O14894	59	86	47	67	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM4SF5	O14894	59	86	68	90	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAB3	Q8N5C8	629	663	2	712	Chain	ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
TAB3	Q8N5C8	601	629	2	712	Chain	ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
TAB3	Q8N5C8	629	663	2	712	Chain	ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
TAB3	Q8N5C8	601	629	2	712	Chain	ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
TAB3	Q8N5C8	629	663	659	662	Compositional bias	Note=Poly-Ala
TAB3	Q8N5C8	629	663	659	662	Compositional bias	Note=Poly-Ala
TAB3	Q8N5C8	629	663	602	629	Alternative sequence	ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965
TAB3	Q8N5C8	601	629	602	629	Alternative sequence	ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965
TAB3	Q8N5C8	629	663	602	629	Alternative sequence	ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965
TAB3	Q8N5C8	601	629	602	629	Alternative sequence	ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965
CD96	P40200	181	197	22	585	Chain	ID=PRO_0000014970;Note=T-cell surface protein tactile
CD96	P40200	315	378	22	585	Chain	ID=PRO_0000014970;Note=T-cell surface protein tactile
CD96	P40200	378	409	22	585	Chain	ID=PRO_0000014970;Note=T-cell surface protein tactile
CD96	P40200	478	508	22	585	Chain	ID=PRO_0000014970;Note=T-cell surface protein tactile
CD96	P40200	181	197	22	519	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	315	378	22	519	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	378	409	22	519	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	478	508	22	519	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	181	197	156	238	Domain	Note=Ig-like V-type 2
CD96	P40200	315	378	269	375	Domain	Note=Ig-like C2-type
CD96	P40200	315	378	370	502	Compositional bias	Note=Pro/Ser/Thr-rich
CD96	P40200	378	409	370	502	Compositional bias	Note=Pro/Ser/Thr-rich
CD96	P40200	478	508	370	502	Compositional bias	Note=Pro/Ser/Thr-rich
CD96	P40200	315	378	350	350	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	315	378	368	368	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	478	508	497	497	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD96	P40200	181	197	163	247	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
CD96	P40200	315	378	290	355	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
CD96	P40200	181	197	182	197	Alternative sequence	ID=VSP_029908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1313846;Dbxref=PMID:1313846
CARS2	Q9HA77	190	218	191	218	Natural variant	ID=VAR_075667;Note=In COXPD27. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25361775;Dbxref=PMID:25361775
CARS2	Q9HA77	190	218	217	217	Natural variant	ID=VAR_075668;Note=In COXPD27. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25787132;Dbxref=PMID:25787132
CARS2	Q9HA77	439	472	440	440	Natural variant	ID=VAR_034523;Note=E->K;Dbxref=dbSNP:rs965189
CARS2	Q9HA77	190	218	182	202	Sequence conflict	Note=RGNAYSTAKGNVYFDLKSRGD->SWERLFNGKRQCLLRSESLEET;Ontology_term=ECO:0000305;evidence=ECO:0000305
CARS2	Q9HA77	190	218	207	223	Sequence conflict	Note=LVGVVPGPVGEPADSDK->IGRRGPWSSPETSGLLTS;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAPPC10	P48553	346	395	1	1259	Chain	ID=PRO_0000193509;Note=Trafficking protein particle complex subunit 10
TRAPPC10	P48553	490	536	1	1259	Chain	ID=PRO_0000193509;Note=Trafficking protein particle complex subunit 10
TRAPPC10	P48553	793	846	1	1259	Chain	ID=PRO_0000193509;Note=Trafficking protein particle complex subunit 10
TRAPPC10	P48553	999	1056	1	1259	Chain	ID=PRO_0000193509;Note=Trafficking protein particle complex subunit 10
TRAPPC10	P48553	1115	1180	1	1259	Chain	ID=PRO_0000193509;Note=Trafficking protein particle complex subunit 10
TRAPPC10	P48553	346	395	277	1259	Alternative sequence	ID=VSP_056590;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAPPC10	P48553	490	536	277	1259	Alternative sequence	ID=VSP_056590;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAPPC10	P48553	793	846	277	1259	Alternative sequence	ID=VSP_056590;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAPPC10	P48553	999	1056	277	1259	Alternative sequence	ID=VSP_056590;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAPPC10	P48553	1115	1180	277	1259	Alternative sequence	ID=VSP_056590;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRAPPC10	P48553	793	846	813	813	Sequence conflict	Note=Y->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
TPCN1	Q9ULQ1	79	138	1	816	Chain	ID=PRO_0000276853;Note=Two pore calcium channel protein 1
TPCN1	Q9ULQ1	314	353	1	816	Chain	ID=PRO_0000276853;Note=Two pore calcium channel protein 1
TPCN1	Q9ULQ1	432	447	1	816	Chain	ID=PRO_0000276853;Note=Two pore calcium channel protein 1
TPCN1	Q9ULQ1	447	466	1	816	Chain	ID=PRO_0000276853;Note=Two pore calcium channel protein 1
TPCN1	Q9ULQ1	466	484	1	816	Chain	ID=PRO_0000276853;Note=Two pore calcium channel protein 1
TPCN1	Q9ULQ1	653	676	1	816	Chain	ID=PRO_0000276853;Note=Two pore calcium channel protein 1
TPCN1	Q9ULQ1	79	138	1	112	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	79	138	113	133	Transmembrane	Note=Helical%3B Name%3DS1 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	79	138	134	134	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	79	138	135	155	Transmembrane	Note=Helical%3B Name%3DS2 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	314	353	295	315	Transmembrane	Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	314	353	316	444	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	432	447	316	444	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	432	447	445	465	Transmembrane	Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	447	466	445	465	Transmembrane	Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	447	466	466	479	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	466	484	466	479	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	466	484	480	500	Transmembrane	Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	653	676	630	653	Intramembrane	Note=Helical%3B Pore-forming;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	653	676	654	670	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	653	676	671	691	Transmembrane	Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPCN1	Q9ULQ1	79	138	1	366	Alternative sequence	ID=VSP_023003;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TPCN1	Q9ULQ1	314	353	1	366	Alternative sequence	ID=VSP_023003;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TPCN1	Q9ULQ1	653	676	619	816	Alternative sequence	ID=VSP_023005;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SYF2	O95926	156	188	2	243	Chain	ID=PRO_0000250376;Note=Pre-mRNA-splicing factor SYF2
SYF2	O95926	44	86	2	243	Chain	ID=PRO_0000250376;Note=Pre-mRNA-splicing factor SYF2
SYF2	O95926	44	86	66	91	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SYF2	O95926	44	86	45	86	Alternative sequence	ID=VSP_054802;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS2	P49590	61	101	34	506	Chain	ID=PRO_0000136336;Note=Probable histidine--tRNA ligase%2C mitochondrial
HARS2	P49590	211	244	34	506	Chain	ID=PRO_0000136336;Note=Probable histidine--tRNA ligase%2C mitochondrial
HARS2	P49590	61	101	67	67	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:23186163,PMID:24275569
HARS2	P49590	61	101	37	61	Alternative sequence	ID=VSP_055133;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRDMT1	O14717	153	181	1	391	Chain	ID=PRO_0000088040;Note=tRNA (cytosine(38)-C(5))-methyltransferase
TRDMT1	O14717	108	129	1	391	Chain	ID=PRO_0000088040;Note=tRNA (cytosine(38)-C(5))-methyltransferase
TRDMT1	O14717	84	107	1	391	Chain	ID=PRO_0000088040;Note=tRNA (cytosine(38)-C(5))-methyltransferase
TRDMT1	O14717	153	181	4	391	Domain	Note=SAM-dependent MTase C5-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01016
TRDMT1	O14717	108	129	4	391	Domain	Note=SAM-dependent MTase C5-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01016
TRDMT1	O14717	84	107	4	391	Domain	Note=SAM-dependent MTase C5-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01016
TRDMT1	O14717	84	107	59	107	Alternative sequence	ID=VSP_005634;Note=In isoform F. GITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILP->RPLDTNNRKLWLSVPRVYIISNLSWHSKFKATIFSYCKASVRAITLSSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	153	181	64	391	Alternative sequence	ID=VSP_005631;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	108	129	64	391	Alternative sequence	ID=VSP_005631;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	84	107	64	391	Alternative sequence	ID=VSP_005631;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	153	181	72	391	Alternative sequence	ID=VSP_005633;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	108	129	72	391	Alternative sequence	ID=VSP_005633;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	84	107	72	391	Alternative sequence	ID=VSP_005633;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	108	129	84	129	Alternative sequence	ID=VSP_005629;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	84	107	84	129	Alternative sequence	ID=VSP_005629;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	84	107	84	107	Alternative sequence	ID=VSP_005628;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	153	181	108	391	Alternative sequence	ID=VSP_005635;Note=In isoform F. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	108	129	108	391	Alternative sequence	ID=VSP_005635;Note=In isoform F. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11551826;Dbxref=PMID:11551826
TRDMT1	O14717	84	107	101	101	Natural variant	ID=VAR_051961;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11254413,PMID:15489334
TRDMT1	O14717	84	107	98	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	108	129	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	84	107	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	108	129	114	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	108	129	124	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	108	129	128	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	153	181	151	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRDMT1	O14717	153	181	162	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G55
TRIM11	Q96F44	168	245	1	468	Chain	ID=PRO_0000056215;Note=E3 ubiquitin-protein ligase TRIM11
TRIM11	Q96F44	168	245	129	208	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM11	Q96F44	168	245	169	169	Alternative sequence	ID=VSP_039628;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRIM11	Q96F44	168	245	234	234	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
RARS	P54136	60	123	1	660	Chain	ID=PRO_0000035797;Note=Arginine--tRNA ligase%2C cytoplasmic
RARS	P54136	317	352	1	660	Chain	ID=PRO_0000035797;Note=Arginine--tRNA ligase%2C cytoplasmic
RARS	P54136	60	123	1	72	Region	Note=Could be involved in the assembly of the multisynthetase complex
RARS	P54136	60	123	1	72	Alternative sequence	ID=VSP_018905;Note=In isoform Monomeric. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RARS	P54136	317	352	341	341	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
RARS	P54136	60	123	76	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	60	123	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	60	123	108	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	60	123	112	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	60	123	117	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	317	352	305	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	317	352	335	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
RARS	P54136	317	352	342	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZAJ
TRIM22	Q8IYM9	141	173	1	498	Chain	ID=PRO_0000056232;Note=E3 ubiquitin-protein ligase TRIM22
TRIM22	Q8IYM9	141	173	132	248	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM22	Q8IYM9	141	173	155	155	Natural variant	ID=VAR_052134;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs7935564,PMID:15489334
TRIM25	Q14258	393	421	1	630	Chain	ID=PRO_0000056233;Note=E3 ubiquitin/ISG15 ligase TRIM25
TRIM25	Q14258	393	421	1	630	Chain	ID=PRO_0000056233;Note=E3 ubiquitin/ISG15 ligase TRIM25
TRIM25	Q14258	199	231	1	630	Chain	ID=PRO_0000056233;Note=E3 ubiquitin/ISG15 ligase TRIM25
TRIM25	Q14258	393	421	180	450	Region	Note=Interaction with influenza A virus NS1
TRIM25	Q14258	393	421	180	450	Region	Note=Interaction with influenza A virus NS1
TRIM25	Q14258	199	231	180	450	Region	Note=Interaction with influenza A virus NS1
TRIM25	Q14258	199	231	217	307	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM25	Q14258	199	231	191	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LTB
TRIM26	Q12899	178	255	1	539	Chain	ID=PRO_0000056235;Note=Tripartite motif-containing protein 26
TRIM26	Q12899	178	255	1	539	Chain	ID=PRO_0000056235;Note=Tripartite motif-containing protein 26
TRIM26	Q12899	178	255	1	539	Chain	ID=PRO_0000056235;Note=Tripartite motif-containing protein 26
TRIM26	Q12899	178	255	188	227	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM26	Q12899	178	255	188	227	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM26	Q12899	178	255	188	227	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM26	Q12899	178	255	197	197	Natural variant	ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565
TRIM26	Q12899	178	255	197	197	Natural variant	ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565
TRIM26	Q12899	178	255	197	197	Natural variant	ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565
TRIM49	P0CI25	169	246	1	452	Chain	ID=PRO_0000056273;Note=Tripartite motif-containing protein 49
TRIM54	Q9BYV2	171	203	1	358	Chain	ID=PRO_0000056282;Note=Tripartite motif-containing protein 54
TRIM54	Q9BYV2	171	203	168	211	Region	Note=Mediates microtubule-binding and homooligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRIM54	Q9BYV2	171	203	171	171	Alternative sequence	ID=VSP_016061;Note=In isoform 2. K->KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11243782;Dbxref=PMID:11243782
TRIM54	Q9BYV2	171	203	172	172	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP4	Q15650	135	206	2	581	Chain	ID=PRO_0000065631;Note=Activating signal cointegrator 1
TRIP4	Q15650	276	347	2	581	Chain	ID=PRO_0000065631;Note=Activating signal cointegrator 1
TRIP4	Q15650	135	206	171	187	Zinc finger	Note=C4-type
TRIP4	Q15650	135	206	200	300	Region	Note=Mediates interaction with DDRGK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	200	300	Region	Note=Mediates interaction with DDRGK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	300	400	Region	Note=Mediates interaction with UFL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	276	276	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRIP4	Q15650	276	347	289	289	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXN3
TRIP4	Q15650	276	347	341	341	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRIP4	Q15650	276	347	324	324	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	325	325	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	334	334	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	135	206	157	157	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP4	Q15650	135	206	157	157	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP4	Q15650	135	206	164	164	Sequence conflict	Note=L->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM178B	H3BS89	165	211	24	294	Chain	ID=PRO_0000419261;Note=Transmembrane protein 178B
TMEM178B	H3BS89	165	211	172	192	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM178B	H3BS89	165	211	206	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULT1A2	P50226	49	91	1	295	Chain	ID=PRO_0000085128;Note=Sulfotransferase 1A2
SULT1A2	P50226	49	91	1	295	Chain	ID=PRO_0000085128;Note=Sulfotransferase 1A2
SULT1A2	P50226	49	91	48	53	Nucleotide binding	Note=PAPS
SULT1A2	P50226	49	91	48	53	Nucleotide binding	Note=PAPS
SULT1A2	P50226	49	91	62	62	Natural variant	ID=VAR_057341;Note=Y->F;Dbxref=dbSNP:rs4987024
SULT1A2	P50226	49	91	62	62	Natural variant	ID=VAR_057341;Note=Y->F;Dbxref=dbSNP:rs4987024
SULT1A2	P50226	49	91	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z29
SULT1A2	P50226	49	91	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z29
SULT1A2	P50226	49	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z29
SULT1A2	P50226	49	91	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z29
STEAP1	Q9UHE8	28	199	1	339	Chain	ID=PRO_0000191694;Note=Metalloreductase STEAP1
STEAP1	Q9UHE8	28	199	71	91	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP1	Q9UHE8	28	199	119	139	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP1	Q9UHE8	28	199	164	184	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP1	Q9UHE8	28	199	118	265	Domain	Note=Ferric oxidoreductase
STEAP1	Q9UHE8	28	199	175	175	Metal binding	Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250
STEAP1	Q9UHE8	28	199	47	47	Natural variant	ID=VAR_053696;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12690205;Dbxref=dbSNP:rs4015375,PMID:12690205
STEAP1	Q9UHE8	28	199	169	169	Natural variant	ID=VAR_053697;Note=F->L;Dbxref=dbSNP:rs2888782
STIL	Q15468	262	290	1	1287	Chain	ID=PRO_0000271332;Note=SCL-interrupting locus protein
STIL	Q15468	234	261	1	1287	Chain	ID=PRO_0000271332;Note=SCL-interrupting locus protein
STIL	Q15468	262	290	1	1018	Region	Note=Interaction with RBM14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25385835;Dbxref=PMID:25385835
STIL	Q15468	234	261	1	1018	Region	Note=Interaction with RBM14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25385835;Dbxref=PMID:25385835
STIL	Q15468	262	290	231	781	Region	Note=Interaction with CENPJ;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22020124,ECO:0000269|PubMed:25385835;Dbxref=PMID:22020124,PMID:25385835
STIL	Q15468	234	261	231	781	Region	Note=Interaction with CENPJ;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22020124,ECO:0000269|PubMed:25385835;Dbxref=PMID:22020124,PMID:25385835
STK10	O94804	779	842	1	968	Chain	ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10
STK10	O94804	335	518	1	968	Chain	ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10
STK10	O94804	290	335	1	968	Chain	ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10
STK10	O94804	198	262	1	968	Chain	ID=PRO_0000086697;Note=Serine/threonine-protein kinase 10
STK10	O94804	290	335	36	294	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK10	O94804	198	262	36	294	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK10	O94804	198	262	175	224	Region	Note=Activation segment
STK10	O94804	779	842	573	947	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STK10	O94804	779	842	750	884	Compositional bias	Note=Gln-rich
STK10	O94804	335	518	438	438	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18088087,PMID:18691976,PMID:19367720,PMID:19369195,PMID:20068231,PMID:23186163
STK10	O94804	335	518	450	450	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
STK10	O94804	335	518	454	454	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
STK10	O94804	335	518	485	485	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
STK10	O94804	335	518	514	514	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
STK10	O94804	290	335	322	322	Natural variant	ID=VAR_041132;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56214442,PMID:17344846
STK10	O94804	335	518	336	336	Natural variant	ID=VAR_041133;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55972616,PMID:17344846
STK10	O94804	335	518	467	467	Natural variant	ID=VAR_041134;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56063773,PMID:17344846
STK10	O94804	335	518	480	480	Natural variant	ID=VAR_051671;Note=P->L;Dbxref=dbSNP:rs34505340
STK10	O94804	290	335	317	317	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK10	O94804	198	262	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	201	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	208	211	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	213	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	217	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	236	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	242	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	198	262	260	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	290	335	292	296	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STK10	O94804	290	335	301	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EIM
STRC	Q7RTU9	1046	1102	23	1775	Chain	ID=PRO_0000022426;Note=Stereocilin
STRC	Q7RTU9	711	732	23	1775	Chain	ID=PRO_0000022426;Note=Stereocilin
SUCLA2	Q9P2R7	178	221	53	463	Chain	ID=PRO_0000033352;Note=Succinate--CoA ligase [ADP-forming] subunit beta%2C mitochondrial;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03220
SUCLA2	Q9P2R7	178	221	61	288	Domain	Note=ATP-grasp;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03220
SUCLA2	Q9P2R7	178	221	216	216	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2I9
SUCLA2	Q9P2R7	178	221	199	199	Natural variant	ID=VAR_013459;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9765291,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7320366,PMID:14702039,PMID:9765291
SUCLA2	Q9P2R7	178	221	203	203	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUCLA2	Q9P2R7	178	221	175	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLA2	Q9P2R7	178	221	179	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLA2	Q9P2R7	178	221	192	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLA2	Q9P2R7	178	221	200	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLA2	Q9P2R7	178	221	203	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLA2	Q9P2R7	178	221	210	212	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLA2	Q9P2R7	178	221	216	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
TOX4	O94842	247	274	1	621	Chain	ID=PRO_0000048568;Note=TOX high mobility group box family member 4
TOX4	O94842	247	274	223	291	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
TOX4	O94842	247	274	271	271	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYCP2	Q9BX26	1277	1329	1	1530	Chain	ID=PRO_0000072366;Note=Synaptonemal complex protein 2
SYCP2	Q9BX26	993	1050	1	1530	Chain	ID=PRO_0000072366;Note=Synaptonemal complex protein 2
SYCP2	Q9BX26	8	56	1	1530	Chain	ID=PRO_0000072366;Note=Synaptonemal complex protein 2
SYCP2	Q9BX26	1277	1329	1	1530	Chain	ID=PRO_0000072366;Note=Synaptonemal complex protein 2
SYCP2	Q9BX26	993	1050	1	1530	Chain	ID=PRO_0000072366;Note=Synaptonemal complex protein 2
SYCP2	Q9BX26	8	56	1	1530	Chain	ID=PRO_0000072366;Note=Synaptonemal complex protein 2
SYCP2	Q9BX26	1277	1329	1295	1295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CUU3
SYCP2	Q9BX26	1277	1329	1295	1295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CUU3
SYCP2	Q9BX26	1277	1329	1297	1297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CUU3
SYCP2	Q9BX26	1277	1329	1297	1297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CUU3
SYPL1	Q16563	152	215	1	259	Chain	ID=PRO_0000179164;Note=Synaptophysin-like protein 1
SYPL1	Q16563	152	215	151	171	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL1	Q16563	152	215	172	212	Topological domain	Note=Vesicular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL1	Q16563	152	215	213	233	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL1	Q16563	152	215	28	237	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
SYPL1	Q16563	152	215	212	212	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL1	Q16563	152	215	163	165	Sequence conflict	Note=LWL->CGW;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYPL2	Q5VXT5	152	216	1	272	Chain	ID=PRO_0000179166;Note=Synaptophysin-like protein 2
SYPL2	Q5VXT5	152	216	151	171	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL2	Q5VXT5	152	216	172	213	Topological domain	Note=Vesicular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL2	Q5VXT5	152	216	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYPL2	Q5VXT5	152	216	30	238	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
SYPL2	Q5VXT5	152	216	213	213	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM65	Q6PJ69	306	328	2	517	Chain	ID=PRO_0000249191;Note=Tripartite motif-containing protein 65
TRIM65	Q6PJ69	138	170	2	517	Chain	ID=PRO_0000249191;Note=Tripartite motif-containing protein 65
TRIM65	Q6PJ69	306	328	313	506	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
TRIM65	Q6PJ69	138	170	139	227	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM66	O15016	1124	1197	1	1216	Chain	ID=PRO_0000220375;Note=Tripartite motif-containing protein 66
TRIM66	O15016	1124	1197	1056	1128	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
TRIM69	Q86WT6	2	161	1	500	Chain	ID=PRO_0000278236;Note=E3 ubiquitin-protein ligase TRIM69
TRIM69	Q86WT6	193	271	1	500	Chain	ID=PRO_0000278236;Note=E3 ubiquitin-protein ligase TRIM69
TRIM69	Q86WT6	2	161	1	500	Chain	ID=PRO_0000278236;Note=E3 ubiquitin-protein ligase TRIM69
TRIM69	Q86WT6	193	271	1	500	Chain	ID=PRO_0000278236;Note=E3 ubiquitin-protein ligase TRIM69
TRIM69	Q86WT6	2	161	41	82	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
TRIM69	Q86WT6	2	161	41	82	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
TRIM69	Q86WT6	2	161	1	152	Region	Note=Necessary for nuclear localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRIM69	Q86WT6	2	161	1	152	Region	Note=Necessary for nuclear localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRIM69	Q86WT6	2	161	161	255	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM69	Q86WT6	193	271	161	255	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM69	Q86WT6	2	161	161	255	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM69	Q86WT6	193	271	161	255	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM69	Q86WT6	2	161	1	204	Alternative sequence	ID=VSP_023200;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TRIM69	Q86WT6	193	271	1	204	Alternative sequence	ID=VSP_023200;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TRIM69	Q86WT6	2	161	1	204	Alternative sequence	ID=VSP_023200;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TRIM69	Q86WT6	193	271	1	204	Alternative sequence	ID=VSP_023200;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TRIM69	Q86WT6	2	161	3	161	Alternative sequence	ID=VSP_023201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRIM69	Q86WT6	2	161	3	161	Alternative sequence	ID=VSP_023201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRIM69	Q86WT6	193	271	255	271	Alternative sequence	ID=VSP_023202;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TRIM69	Q86WT6	193	271	255	271	Alternative sequence	ID=VSP_023202;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TRIM69	Q86WT6	2	161	12	12	Natural variant	ID=VAR_057226;Note=D->N;Dbxref=dbSNP:rs2444007
TRIM69	Q86WT6	2	161	12	12	Natural variant	ID=VAR_057226;Note=D->N;Dbxref=dbSNP:rs2444007
TRIM69	Q86WT6	2	161	15	15	Natural variant	ID=VAR_057227;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2470911,PMID:15489334
TRIM69	Q86WT6	2	161	15	15	Natural variant	ID=VAR_057227;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2470911,PMID:15489334
TRIM69	Q86WT6	2	161	31	31	Natural variant	ID=VAR_030704;Note=V->A;Dbxref=dbSNP:rs3759880
TRIM69	Q86WT6	2	161	31	31	Natural variant	ID=VAR_030704;Note=V->A;Dbxref=dbSNP:rs3759880
TRIM69	Q86WT6	2	161	104	104	Natural variant	ID=VAR_057228;Note=K->R;Dbxref=dbSNP:rs17588988
TRIM69	Q86WT6	2	161	104	104	Natural variant	ID=VAR_057228;Note=K->R;Dbxref=dbSNP:rs17588988
TRIM69	Q86WT6	2	161	161	161	Natural variant	ID=VAR_057229;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3100139,PMID:15489334
TRIM69	Q86WT6	2	161	161	161	Natural variant	ID=VAR_057229;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3100139,PMID:15489334
TRIM69	Q86WT6	2	161	61	61	Mutagenesis	Note=Loss of E3 ubiquitin-protein ligase activity%3B when associated with A-64. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23131556;Dbxref=PMID:23131556
TRIM69	Q86WT6	2	161	61	61	Mutagenesis	Note=Loss of E3 ubiquitin-protein ligase activity%3B when associated with A-64. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23131556;Dbxref=PMID:23131556
TRIM69	Q86WT6	2	161	64	64	Mutagenesis	Note=Loss of E3 ubiquitin-protein ligase activity%3B when associated with A-61. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23131556;Dbxref=PMID:23131556
TRIM69	Q86WT6	2	161	64	64	Mutagenesis	Note=Loss of E3 ubiquitin-protein ligase activity%3B when associated with A-61. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23131556;Dbxref=PMID:23131556
TRIM69	Q86WT6	2	161	144	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	2	161	144	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	2	161	153	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	193	271	153	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	2	161	153	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	193	271	153	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	193	271	266	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM69	Q86WT6	193	271	266	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NQJ
TRIM73	Q86UV7	133	165	1	250	Chain	ID=PRO_0000056278;Note=Tripartite motif-containing protein 73
TRIM73	Q86UV7	133	165	1	250	Chain	ID=PRO_0000056278;Note=Tripartite motif-containing protein 73
TRIM73	Q86UV7	133	165	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM73	Q86UV7	133	165	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIP11	Q15643	1819	1858	2	1979	Chain	ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11
TRIP11	Q15643	509	1519	2	1979	Chain	ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11
TRIP11	Q15643	409	438	2	1979	Chain	ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11
TRIP11	Q15643	104	196	2	1979	Chain	ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11
TRIP11	Q15643	1819	1858	1774	1823	Domain	Note=GRIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00250
TRIP11	Q15643	509	1519	52	1773	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIP11	Q15643	409	438	52	1773	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIP11	Q15643	104	196	52	1773	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIP11	Q15643	1819	1858	1842	1842	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
TRIP11	Q15643	1819	1858	1846	1846	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
TRIP11	Q15643	509	1519	559	559	Natural variant	ID=VAR_079175;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27717682;Dbxref=PMID:27717682
TRIP11	Q15643	509	1519	795	795	Natural variant	ID=VAR_055863;Note=V->L;Dbxref=dbSNP:rs34699762
TRIP11	Q15643	509	1519	884	884	Natural variant	ID=VAR_055864;Note=D->G;Dbxref=dbSNP:rs34967261
TRIP11	Q15643	509	1519	1040	1040	Natural variant	ID=VAR_055865;Note=I->V;Dbxref=dbSNP:rs34805848
TRIP11	Q15643	509	1519	1107	1107	Natural variant	ID=VAR_060344;Note=E->D;Dbxref=dbSNP:rs4619320
TRIP11	Q15643	509	1519	1413	1413	Natural variant	ID=VAR_060345;Note=D->A;Dbxref=dbSNP:rs12884523
TRIP11	Q15643	509	1519	1503	1503	Natural variant	ID=VAR_055866;Note=M->V;Dbxref=dbSNP:rs34839498
TRIP11	Q15643	1819	1858	1827	1827	Natural variant	ID=VAR_060346;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10189370,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7776974,ECO:0000269|PubMed:9373237;Dbxref=dbSNP:rs1051340,PMID:10189370,PMID:15489334,PMID:7776974,PMID:9373237
TRIP11	Q15643	1819	1858	1846	1846	Natural variant	ID=VAR_054151;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18987736;Dbxref=dbSNP:rs141259390,PMID:18987736
TRIP11	Q15643	104	196	121	121	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP11	Q15643	509	1519	516	516	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP11	Q15643	509	1519	561	563	Sequence conflict	Note=KEK->FVL;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP11	Q15643	509	1519	1202	1202	Sequence conflict	Note=N->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP11	Q15643	509	1519	1237	1237	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP11	Q15643	509	1519	1346	1347	Sequence conflict	Note=QQ->HE;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRMT112	Q9UI30	26	60	1	125	Chain	ID=PRO_0000215797;Note=Multifunctional methyltransferase subunit TRM112-like protein
TRMT112	Q9UI30	26	60	2	119	Domain	Note=TRM112
TNFRSF11B	O00300	197	272	22	401	Chain	ID=PRO_0000034587;Note=Tumor necrosis factor receptor superfamily member 11B
TNFRSF11B	O00300	133	197	22	401	Chain	ID=PRO_0000034587;Note=Tumor necrosis factor receptor superfamily member 11B
TNFRSF11B	O00300	133	197	107	142	Repeat	Note=TNFR-Cys 3
TNFRSF11B	O00300	133	197	145	185	Repeat	Note=TNFR-Cys 4
TNFRSF11B	O00300	197	272	198	269	Domain	Note=Death 1
TNFRSF11B	O00300	197	272	270	365	Domain	Note=Death 2
TNFRSF11B	O00300	133	197	152	152	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11B	O00300	133	197	165	165	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF11B	O00300	133	197	178	178	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22664871;Dbxref=PMID:22664871
TNFRSF11B	O00300	133	197	124	142	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00206,ECO:0000269|PubMed:22664871;Dbxref=PMID:22664871
TNFRSF11B	O00300	133	197	145	160	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00206,ECO:0000269|PubMed:22664871;Dbxref=PMID:22664871
TNFRSF11B	O00300	133	197	166	185	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00206,ECO:0000269|PubMed:22664871;Dbxref=PMID:22664871
TNFRSF11B	O00300	133	197	182	182	Natural variant	ID=VAR_019413;Note=In PDB5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12189164;Dbxref=PMID:12189164
TNFRSF11B	O00300	197	272	263	263	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNFRSF11B	O00300	133	197	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3URF
TNFRSF11B	O00300	133	197	141	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3URF
TNFRSF11B	O00300	133	197	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3URF
TNFRSF11B	O00300	133	197	167	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3URF
RELT	Q969Z4	122	208	26	430	Chain	ID=PRO_0000034599;Note=Tumor necrosis factor receptor superfamily member 19L
RELT	Q969Z4	263	348	26	430	Chain	ID=PRO_0000034599;Note=Tumor necrosis factor receptor superfamily member 19L
RELT	Q969Z4	122	208	26	430	Chain	ID=PRO_0000034599;Note=Tumor necrosis factor receptor superfamily member 19L
RELT	Q969Z4	263	348	26	430	Chain	ID=PRO_0000034599;Note=Tumor necrosis factor receptor superfamily member 19L
RELT	Q969Z4	122	208	26	162	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	26	162	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	163	183	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	163	183	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	184	430	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	263	348	184	430	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	184	430	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	263	348	184	430	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	149	149	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	122	208	149	149	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RELT	Q969Z4	263	348	332	332	Natural variant	ID=VAR_022614;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12362779,PMID:15489334
RELT	Q969Z4	263	348	332	332	Natural variant	ID=VAR_022614;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12362779,PMID:15489334
RELT	Q969Z4	122	208	122	122	Sequence conflict	Note=D->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RELT	Q969Z4	122	208	122	122	Sequence conflict	Note=D->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RELT	Q969Z4	122	208	187	187	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RELT	Q969Z4	122	208	187	187	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RELT	Q969Z4	263	348	273	273	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RELT	Q969Z4	263	348	273	273	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRA2A	Q13595	214	256	2	282	Chain	ID=PRO_0000081981;Note=Transformer-2 protein homolog alpha
TRA2A	Q13595	112	175	2	282	Chain	ID=PRO_0000081981;Note=Transformer-2 protein homolog alpha
TRA2A	Q13595	112	175	119	197	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
TRA2A	Q13595	214	256	198	225	Region	Note=Linker
TRA2A	Q13595	112	175	30	112	Compositional bias	Note=Arg/Ser-rich (RS1 domain)
TRA2A	Q13595	214	256	226	282	Compositional bias	Note=Arg/Ser-rich (RS2 domain)
TRA2A	Q13595	214	256	232	232	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6PFR5
TRA2A	Q13595	214	256	236	236	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRA2A	Q13595	214	256	214	214	Alternative sequence	ID=VSP_005894;Note=In isoform Short. H->Q;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8799144;Dbxref=PMID:8799144
TRA2A	Q13595	214	256	215	282	Alternative sequence	ID=VSP_005895;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8799144;Dbxref=PMID:8799144
SYNE4	Q8N205	206	289	1	404	Chain	ID=PRO_0000306264;Note=Nesprin-4
SYNE4	Q8N205	141	206	1	404	Chain	ID=PRO_0000306264;Note=Nesprin-4
SYNE4	Q8N205	93	141	1	404	Chain	ID=PRO_0000306264;Note=Nesprin-4
SYNE4	Q8N205	206	289	1	355	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00385
SYNE4	Q8N205	141	206	1	355	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00385
SYNE4	Q8N205	93	141	1	355	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00385
SYNE4	Q8N205	206	289	94	206	Alternative sequence	ID=VSP_028444;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SYNE4	Q8N205	141	206	94	206	Alternative sequence	ID=VSP_028444;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SYNE4	Q8N205	93	141	94	206	Alternative sequence	ID=VSP_028444;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SYNE4	Q8N205	206	289	224	224	Natural variant	ID=VAR_035284;Note=S->L;Dbxref=dbSNP:rs34818970
SYNE4	Q8N205	206	289	278	278	Natural variant	ID=VAR_035285;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2285422,PMID:15489334
SYNDIG1	Q9H7V2	160	206	1	258	Chain	ID=PRO_0000135696;Note=Synapse differentiation-inducing gene protein 1
SYNDIG1	Q9H7V2	160	206	1	181	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNDIG1	Q9H7V2	160	206	182	202	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNDIG1	Q9H7V2	160	206	203	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM44	Q96DX7	249	329	1	344	Chain	ID=PRO_0000220372;Note=Tripartite motif-containing protein 44
TRIM44	Q96DX7	249	329	290	325	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM50	Q86XT4	133	165	1	487	Chain	ID=PRO_0000056274;Note=E3 ubiquitin-protein ligase TRIM50
TRIM50	Q86XT4	133	165	1	487	Chain	ID=PRO_0000056274;Note=E3 ubiquitin-protein ligase TRIM50
TRIM50	Q86XT4	133	165	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM50	Q86XT4	133	165	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SARS	P49591	149	197	1	514	Chain	ID=PRO_0000122191;Note=Serine--tRNA ligase%2C cytoplasmic
SARS	P49591	149	197	172	172	Natural variant	ID=VAR_078434;Note=In NEDMAS%3B impaired serine-activation of enzyme resulting in a significant decrease in the first step of the aminoacylation reaction%3B reduced protein stability%3B reduced protein expression. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28236339;Dbxref=PMID:28236339
SARS	P49591	149	197	149	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VBB
SARS	P49591	149	197	154	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VBB
SARS	P49591	149	197	170	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VBB
SARS	P49591	149	197	183	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VBB
SARS	P49591	149	197	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VBB
TRMT1	Q9NXH9	392	437	1	659	Chain	ID=PRO_0000147671;Note=tRNA (guanine(26)-N(2))-dimethyltransferase
TRMT1	Q9NXH9	340	368	1	659	Chain	ID=PRO_0000147671;Note=tRNA (guanine(26)-N(2))-dimethyltransferase
TRMT1	Q9NXH9	392	437	1	659	Chain	ID=PRO_0000147671;Note=tRNA (guanine(26)-N(2))-dimethyltransferase
TRMT1	Q9NXH9	340	368	1	659	Chain	ID=PRO_0000147671;Note=tRNA (guanine(26)-N(2))-dimethyltransferase
TRMT1	Q9NXH9	392	437	1	659	Chain	ID=PRO_0000147671;Note=tRNA (guanine(26)-N(2))-dimethyltransferase
TRMT1	Q9NXH9	340	368	1	659	Chain	ID=PRO_0000147671;Note=tRNA (guanine(26)-N(2))-dimethyltransferase
TRMT1	Q9NXH9	392	437	55	499	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1	Q9NXH9	340	368	55	499	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1	Q9NXH9	392	437	55	499	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1	Q9NXH9	340	368	55	499	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1	Q9NXH9	392	437	55	499	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1	Q9NXH9	340	368	55	499	Domain	Note=Trm1 methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00958
TRMT1	Q9NXH9	340	368	340	368	Alternative sequence	ID=VSP_016720;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRMT1	Q9NXH9	340	368	340	368	Alternative sequence	ID=VSP_016720;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRMT1	Q9NXH9	340	368	340	368	Alternative sequence	ID=VSP_016720;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SYTL1	Q8IYJ3	211	249	1	562	Chain	ID=PRO_0000190211;Note=Synaptotagmin-like protein 1
SYTL1	Q8IYJ3	335	388	1	562	Chain	ID=PRO_0000190211;Note=Synaptotagmin-like protein 1
SYTL1	Q8IYJ3	335	388	268	368	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYTL1	Q8IYJ3	211	249	237	258	Compositional bias	Note=Ser-rich
SYTL1	Q8IYJ3	211	249	216	216	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SYTL4	Q96C24	429	483	1	671	Chain	ID=PRO_0000190216;Note=Synaptotagmin-like protein 4
SYTL4	Q96C24	180	213	1	671	Chain	ID=PRO_0000190216;Note=Synaptotagmin-like protein 4
SYTL4	Q96C24	429	483	1	671	Chain	ID=PRO_0000190216;Note=Synaptotagmin-like protein 4
SYTL4	Q96C24	180	213	1	671	Chain	ID=PRO_0000190216;Note=Synaptotagmin-like protein 4
SYTL4	Q96C24	429	483	1	671	Chain	ID=PRO_0000190216;Note=Synaptotagmin-like protein 4
SYTL4	Q96C24	180	213	1	671	Chain	ID=PRO_0000190216;Note=Synaptotagmin-like protein 4
SYTL4	Q96C24	429	483	358	462	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYTL4	Q96C24	429	483	358	462	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYTL4	Q96C24	429	483	358	462	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYTL4	Q96C24	180	213	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R0Q1
SYTL4	Q96C24	180	213	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R0Q1
SYTL4	Q96C24	180	213	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R0Q1
SYTL4	Q96C24	180	213	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SYTL4	Q96C24	180	213	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SYTL4	Q96C24	180	213	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SYTL4	Q96C24	429	483	336	657	Alternative sequence	ID=VSP_015237;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SYTL4	Q96C24	429	483	336	657	Alternative sequence	ID=VSP_015237;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SYTL4	Q96C24	429	483	336	657	Alternative sequence	ID=VSP_015237;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SYTL4	Q96C24	429	483	423	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	423	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	423	431	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	437	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	437	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	437	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	441	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	441	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	441	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	451	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	451	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	451	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	455	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	455	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	455	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	465	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	465	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	465	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	469	471	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	469	471	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	469	471	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	474	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	474	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SYTL4	Q96C24	429	483	474	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FDW
SOAT1	P35610	130	165	1	550	Chain	ID=PRO_0000207640;Note=Sterol O-acyltransferase 1
SOAT1	P35610	130	165	1	140	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SOAT1	P35610	130	165	141	159	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SOAT1	P35610	130	165	160	181	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SOS1	Q07889	1115	1130	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	797	836	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	288	325	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	240	288	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	71	115	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	29	71	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	1115	1130	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	797	836	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	288	325	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	240	288	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	71	115	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	29	71	1	1333	Chain	ID=PRO_0000068894;Note=Son of sevenless homolog 1
SOS1	Q07889	288	325	200	390	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS1	Q07889	240	288	200	390	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS1	Q07889	288	325	200	390	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS1	Q07889	240	288	200	390	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS1	Q07889	797	836	780	1019	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
SOS1	Q07889	797	836	780	1019	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
SOS1	Q07889	29	71	1	57	Alternative sequence	ID=VSP_056463;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SOS1	Q07889	29	71	1	57	Alternative sequence	ID=VSP_056463;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SOS1	Q07889	1115	1130	372	1333	Alternative sequence	ID=VSP_056465;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SOS1	Q07889	797	836	372	1333	Alternative sequence	ID=VSP_056465;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SOS1	Q07889	1115	1130	372	1333	Alternative sequence	ID=VSP_056465;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SOS1	Q07889	797	836	372	1333	Alternative sequence	ID=VSP_056465;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SOS1	Q07889	29	71	37	37	Natural variant	ID=VAR_066031;Note=In a patient with Noonan syndrome. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs150565592,PMID:21387466
SOS1	Q07889	29	71	37	37	Natural variant	ID=VAR_066031;Note=In a patient with Noonan syndrome. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs150565592,PMID:21387466
SOS1	Q07889	71	115	102	102	Natural variant	ID=VAR_066032;Note=In NS4. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953625;Dbxref=PMID:19953625
SOS1	Q07889	71	115	102	102	Natural variant	ID=VAR_066032;Note=In NS4. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953625;Dbxref=PMID:19953625
SOS1	Q07889	71	115	108	108	Natural variant	ID=VAR_030423;Note=In NS4. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17143282,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs397517164,PMID:17143282,PMID:21387466
SOS1	Q07889	71	115	108	108	Natural variant	ID=VAR_030423;Note=In NS4. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17143282,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs397517164,PMID:17143282,PMID:21387466
SOS1	Q07889	71	115	112	112	Natural variant	ID=VAR_066033;Note=In NS4. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs397517166,PMID:21387466
SOS1	Q07889	71	115	112	112	Natural variant	ID=VAR_066033;Note=In NS4. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs397517166,PMID:21387466
SOS1	Q07889	240	288	252	252	Natural variant	ID=VAR_066035;Note=In NS4. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs142094234,PMID:21387466
SOS1	Q07889	240	288	252	252	Natural variant	ID=VAR_066035;Note=In NS4. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs142094234,PMID:21387466
SOS1	Q07889	240	288	266	266	Natural variant	ID=VAR_030424;Note=In NS4. T->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17143285,ECO:0000269|PubMed:19953625,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs137852812,PMID:17143285,PMID:19953625,PMID:21387466
SOS1	Q07889	240	288	266	266	Natural variant	ID=VAR_030424;Note=In NS4. T->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17143285,ECO:0000269|PubMed:19953625,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs137852812,PMID:17143285,PMID:19953625,PMID:21387466
SOS1	Q07889	240	288	269	269	Natural variant	ID=VAR_030425;Note=In NS4. M->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17143282,ECO:0000269|PubMed:17143285,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs137852813,PMID:17143282,PMID:17143285,PMID:21387466
SOS1	Q07889	240	288	269	269	Natural variant	ID=VAR_030425;Note=In NS4. M->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17143282,ECO:0000269|PubMed:17143285,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs137852813,PMID:17143282,PMID:17143285,PMID:21387466
SOS1	Q07889	240	288	269	269	Natural variant	ID=VAR_064504;Note=In NS4. M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19953625,ECO:0000269|PubMed:20683980,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs137852813,PMID:19953625,PMID:20683980,PMID:21387466
SOS1	Q07889	240	288	269	269	Natural variant	ID=VAR_064504;Note=In NS4. M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19953625,ECO:0000269|PubMed:20683980,ECO:0000269|PubMed:21387466;Dbxref=dbSNP:rs137852813,PMID:19953625,PMID:20683980,PMID:21387466
SOS1	Q07889	288	325	309	309	Natural variant	ID=VAR_030426;Note=In NS4. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17143285;Dbxref=dbSNP:rs397517180,PMID:17143285
SOS1	Q07889	288	325	309	309	Natural variant	ID=VAR_030426;Note=In NS4. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17143285;Dbxref=dbSNP:rs397517180,PMID:17143285
SOS1	Q07889	240	288	282	282	Mutagenesis	Note=Increases MAPK3 phosphorylation in response to EGF stimulation. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17339331;Dbxref=PMID:17339331
SOS1	Q07889	240	288	282	282	Mutagenesis	Note=Increases MAPK3 phosphorylation in response to EGF stimulation. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17339331;Dbxref=PMID:17339331
SOS1	Q07889	29	71	24	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	29	71	24	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	29	71	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q9C
SOS1	Q07889	29	71	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q9C
SOS1	Q07889	29	71	42	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	29	71	42	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	67	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	29	71	67	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	67	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	29	71	67	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	82	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	82	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	71	115	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KSY
SOS1	Q07889	240	288	239	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	239	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	249	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	249	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	274	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	274	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	280	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	280	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	280	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	240	288	280	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	289	292	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	289	292	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	293	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	293	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	307	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	307	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	320	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	288	325	320	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DBH
SOS1	Q07889	797	836	781	797	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	781	797	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	801	803	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	801	803	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	805	807	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	805	807	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	808	810	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NYJ
SOS1	Q07889	797	836	808	810	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NYJ
SOS1	Q07889	797	836	814	817	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	814	817	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	819	840	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SOS1	Q07889	797	836	819	840	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WFO
SNX1	Q13596	407	455	1	522	Chain	ID=PRO_0000213835;Note=Sorting nexin-1
SNX1	Q13596	455	482	1	522	Chain	ID=PRO_0000213835;Note=Sorting nexin-1
SNX1	Q13596	407	455	302	522	Domain	Note=BAR
SNX1	Q13596	455	482	302	522	Domain	Note=BAR
SNX1	Q13596	455	482	466	466	Natural variant	ID=VAR_034507;Note=D->N;Dbxref=dbSNP:rs1802376
SNX1	Q13596	407	455	429	431	Mutagenesis	Note=Loss of endosomal location. KKR->EEE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15498486;Dbxref=PMID:15498486
SNX1	Q13596	407	455	442	442	Mutagenesis	Note=No effect on membrane remodeling and membrane binding%3B when associated with A-445. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23085988;Dbxref=PMID:23085988
SNX1	Q13596	407	455	445	445	Mutagenesis	Note=No effect on membrane remodeling and membrane binding%3B when associated with A-442. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23085988;Dbxref=PMID:23085988
SNX1	Q13596	407	455	388	440	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FZS
SNX1	Q13596	407	455	443	483	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FZS
SNX1	Q13596	455	482	443	483	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FZS
SRM	P19623	255	296	1	302	Chain	ID=PRO_0000156445;Note=Spermidine synthase
SRM	P19623	255	296	259	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O07
SRM	P19623	255	296	268	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O07
SRM	P19623	255	296	281	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O07
SRM	P19623	255	296	292	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O07
TMEM145	Q8NBT3	65	91	1	493	Chain	ID=PRO_0000280355;Note=Transmembrane protein 145
TMEM147	Q9BVK8	49	69	1	224	Chain	ID=PRO_0000271701;Note=Transmembrane protein 147
TMEM147	Q9BVK8	49	69	38	58	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM147	Q9BVK8	49	69	1	49	Alternative sequence	ID=VSP_047210;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPAG17	Q6Q759	1957	2001	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	1874	1889	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	1726	1787	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	1106	1144	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	757	795	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	337	391	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	211	276	1	2223	Chain	ID=PRO_0000331445;Note=Sperm-associated antigen 17
SPAG17	Q6Q759	211	276	266	295	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPAG17	Q6Q759	1874	1889	1874	1907	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPAG17	Q6Q759	211	276	211	211	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM209	Q96SK2	373	415	1	561	Chain	ID=PRO_0000331632;Note=Transmembrane protein 209
TMEM209	Q96SK2	66	110	1	561	Chain	ID=PRO_0000331632;Note=Transmembrane protein 209
TMEM209	Q96SK2	66	110	60	80	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM209	Q96SK2	66	110	98	98	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231;Dbxref=PMID:18691976,PMID:20068231
TMEM209	Q96SK2	373	415	204	561	Alternative sequence	ID=VSP_033282;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM209	Q96SK2	373	415	375	416	Alternative sequence	ID=VSP_033283;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM209	Q96SK2	373	415	379	379	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM209	Q96SK2	373	415	395	395	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPINT2	O43291	35	92	28	252	Chain	ID=PRO_0000016885;Note=Kunitz-type protease inhibitor 2
SPINT2	O43291	92	112	28	252	Chain	ID=PRO_0000016885;Note=Kunitz-type protease inhibitor 2
SPINT2	O43291	35	92	28	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPINT2	O43291	92	112	28	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPINT2	O43291	35	92	38	88	Domain	Note=BPTI/Kunitz inhibitor 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
SPINT2	O43291	35	92	48	49	Site	Note=Reactive bond;Ontology_term=ECO:0000250;evidence=ECO:0000250
SPINT2	O43291	35	92	57	57	Glycosylation	Note=N-linked (GlcNAc...) asparagine
SPINT2	O43291	92	112	94	94	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPINT2	O43291	35	92	38	88	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
SPINT2	O43291	35	92	47	71	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
SPINT2	O43291	35	92	63	84	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
SPINT2	O43291	35	92	36	92	Alternative sequence	ID=VSP_043680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPINT2	O43291	92	112	36	92	Alternative sequence	ID=VSP_043680;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPINT2	O43291	35	92	53	53	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPINT2	O43291	35	92	36	38	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
SPINT2	O43291	35	92	51	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
SPINT2	O43291	35	92	58	61	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
SPINT2	O43291	35	92	62	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
SPINT2	O43291	35	92	70	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
SPINT2	O43291	35	92	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
SPINT2	O43291	35	92	81	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U32
TMEM242	Q9NWH2	63	109	1	141	Chain	ID=PRO_0000295848;Note=Transmembrane protein 242
TMEM242	Q9NWH2	63	109	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SNUPN	O95149	226	253	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	200	226	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	101	136	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	226	253	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	200	226	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	101	136	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	226	253	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	200	226	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	101	136	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	226	253	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	200	226	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	101	136	1	360	Chain	ID=PRO_0000191071;Note=Snurportin-1
SNUPN	O95149	101	136	1	159	Region	Note=Necessary for interaction with XPO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10209022;Dbxref=PMID:10209022
SNUPN	O95149	101	136	1	159	Region	Note=Necessary for interaction with XPO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10209022;Dbxref=PMID:10209022
SNUPN	O95149	101	136	1	159	Region	Note=Necessary for interaction with XPO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10209022;Dbxref=PMID:10209022
SNUPN	O95149	101	136	1	159	Region	Note=Necessary for interaction with XPO1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10209022;Dbxref=PMID:10209022
SNUPN	O95149	101	136	127	129	Region	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	127	129	Region	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	127	129	Region	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	127	129	Region	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	226	253	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	200	226	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	226	253	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	200	226	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	226	253	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	200	226	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	226	253	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	200	226	208	328	Region	Note=Necessary for binding to the m3G-cap structure;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670026;Dbxref=PMID:9670026
SNUPN	O95149	101	136	105	105	Site	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	105	105	Site	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	105	105	Site	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	105	105	Site	Note=Interaction with m3G-cap structure;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XK5,ECO:0000269|PubMed:15920472;Dbxref=PMID:15920472
SNUPN	O95149	101	136	107	107	Mutagenesis	Note=Reduces binding to m3G-cap structure%2C interaction with XPO1 and snRNP import receptor activity. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15920472,ECO:0000269|PubMed:16030253;Dbxref=PMID:15920472,PMID:16030253
SNUPN	O95149	101	136	107	107	Mutagenesis	Note=Reduces binding to m3G-cap structure%2C interaction with XPO1 and snRNP import receptor activity. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15920472,ECO:0000269|PubMed:16030253;Dbxref=PMID:15920472,PMID:16030253
SNUPN	O95149	101	136	107	107	Mutagenesis	Note=Reduces binding to m3G-cap structure%2C interaction with XPO1 and snRNP import receptor activity. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15920472,ECO:0000269|PubMed:16030253;Dbxref=PMID:15920472,PMID:16030253
SNUPN	O95149	101	136	107	107	Mutagenesis	Note=Reduces binding to m3G-cap structure%2C interaction with XPO1 and snRNP import receptor activity. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15920472,ECO:0000269|PubMed:16030253;Dbxref=PMID:15920472,PMID:16030253
SNUPN	O95149	200	226	203	207	Mutagenesis	Note=Reduces binding to m3G-cap structure. FRFYW->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16030253;Dbxref=PMID:16030253
SNUPN	O95149	200	226	203	207	Mutagenesis	Note=Reduces binding to m3G-cap structure. FRFYW->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16030253;Dbxref=PMID:16030253
SNUPN	O95149	200	226	203	207	Mutagenesis	Note=Reduces binding to m3G-cap structure. FRFYW->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16030253;Dbxref=PMID:16030253
SNUPN	O95149	200	226	203	207	Mutagenesis	Note=Reduces binding to m3G-cap structure. FRFYW->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16030253;Dbxref=PMID:16030253
SNUPN	O95149	101	136	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	115	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	115	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	115	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	115	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	119	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	119	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	119	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	101	136	119	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	201	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	212	214	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	212	214	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	212	214	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	212	214	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	216	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	216	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	216	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	216	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	200	226	225	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	234	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	234	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	234	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	234	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	239	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	239	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	239	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
SNUPN	O95149	226	253	239	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XK5
NCKIPSD	Q9NZQ3	523	566	1	722	Chain	ID=PRO_0000072130;Note=NCK-interacting protein with SH3 domain
NCKIPSD	Q9NZQ3	496	523	1	722	Chain	ID=PRO_0000072130;Note=NCK-interacting protein with SH3 domain
NCKIPSD	Q9NZQ3	523	566	534	601	Compositional bias	Note=Leu-rich
TM6SF2	Q9BZW4	268	308	1	377	Chain	ID=PRO_0000181835;Note=Transmembrane 6 superfamily member 2
TM6SF2	Q9BZW4	268	308	269	289	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM6SF2	Q9BZW4	268	308	217	351	Domain	Note=EXPERA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01087
TMEM87B	Q96K49	106	150	43	555	Chain	ID=PRO_0000291753;Note=Transmembrane protein 87B
TMEM87B	Q96K49	150	167	43	555	Chain	ID=PRO_0000291753;Note=Transmembrane protein 87B
TMEM87B	Q96K49	106	150	43	214	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM87B	Q96K49	150	167	43	214	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM87B	Q96K49	150	167	167	167	Alternative sequence	ID=VSP_026219;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TM9SF2	Q99805	383	423	29	663	Chain	ID=PRO_0000034365;Note=Transmembrane 9 superfamily member 2
TM9SF2	Q99805	383	423	375	395	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF2	Q99805	383	423	396	398	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF2	Q99805	383	423	399	419	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF2	Q99805	383	423	420	437	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF4	Q92544	415	443	24	642	Chain	ID=PRO_0000210178;Note=Transmembrane 9 superfamily member 4
TM9SF4	Q92544	523	563	24	642	Chain	ID=PRO_0000210178;Note=Transmembrane 9 superfamily member 4
TM9SF4	Q92544	415	443	398	416	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF4	Q92544	415	443	417	437	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF4	Q92544	415	443	438	449	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF4	Q92544	523	563	523	535	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF4	Q92544	523	563	536	556	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF4	Q92544	523	563	557	570	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPRED1	Q7Z699	141	194	2	444	Chain	ID=PRO_0000076907;Note=Sprouty-related%2C EVH1 domain-containing protein 1
SPRED1	Q7Z699	141	194	147	150	Compositional bias	Note=Poly-Ser
SPRED2	Q7Z698	146	196	1	418	Chain	ID=PRO_0000076910;Note=Sprouty-related%2C EVH1 domain-containing protein 2
TMC5	Q6UXY8	594	646	1	1006	Chain	ID=PRO_0000289966;Note=Transmembrane channel-like protein 5
TMC5	Q6UXY8	858	915	1	1006	Chain	ID=PRO_0000289966;Note=Transmembrane channel-like protein 5
TMC5	Q6UXY8	942	977	1	1006	Chain	ID=PRO_0000289966;Note=Transmembrane channel-like protein 5
TMC5	Q6UXY8	594	646	1	1006	Chain	ID=PRO_0000289966;Note=Transmembrane channel-like protein 5
TMC5	Q6UXY8	858	915	1	1006	Chain	ID=PRO_0000289966;Note=Transmembrane channel-like protein 5
TMC5	Q6UXY8	942	977	1	1006	Chain	ID=PRO_0000289966;Note=Transmembrane channel-like protein 5
TMC5	Q6UXY8	594	646	547	619	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	594	646	547	619	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	594	646	620	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	594	646	620	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	594	646	641	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	594	646	641	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	858	915	857	900	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	858	915	857	900	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	858	915	901	921	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	858	915	901	921	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	942	977	922	1006	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	942	977	922	1006	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC5	Q6UXY8	858	915	859	916	Alternative sequence	ID=VSP_026046;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
TMC5	Q6UXY8	858	915	859	916	Alternative sequence	ID=VSP_026046;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SPATA22	Q8NHS9	78	109	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	14	57	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	78	109	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	14	57	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	78	109	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	14	57	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	78	109	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	14	57	1	363	Chain	ID=PRO_0000251605;Note=Spermatogenesis-associated protein 22
SPATA22	Q8NHS9	14	57	15	57	Alternative sequence	ID=VSP_020763;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15713825;Dbxref=PMID:15713825
SPATA22	Q8NHS9	14	57	15	57	Alternative sequence	ID=VSP_020763;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15713825;Dbxref=PMID:15713825
SPATA22	Q8NHS9	14	57	15	57	Alternative sequence	ID=VSP_020763;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15713825;Dbxref=PMID:15713825
SPATA22	Q8NHS9	14	57	15	57	Alternative sequence	ID=VSP_020763;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15713825;Dbxref=PMID:15713825
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	84	84	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	106	106	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	106	106	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	106	106	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA22	Q8NHS9	78	109	106	106	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMF1	P82094	1004	1046	1	1093	Chain	ID=PRO_0000072589;Note=TATA element modulatory factor
TMF1	P82094	953	1004	1	1093	Chain	ID=PRO_0000072589;Note=TATA element modulatory factor
TMF1	P82094	919	953	1	1093	Chain	ID=PRO_0000072589;Note=TATA element modulatory factor
TMF1	P82094	888	919	1	1093	Chain	ID=PRO_0000072589;Note=TATA element modulatory factor
TMF1	P82094	919	953	439	922	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMF1	P82094	888	919	439	922	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMF1	P82094	1004	1046	984	1092	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMF1	P82094	953	1004	984	1092	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMF1	P82094	919	953	925	925	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TMF1	P82094	919	953	928	928	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9EKI3
TMF1	P82094	919	953	929	929	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9EKI3
TMF1	P82094	919	953	933	933	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUPT5H	O00267	208	292	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	510	559	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	678	718	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	1008	1040	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	208	292	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	510	559	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	678	718	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	1008	1040	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	208	292	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	510	559	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	678	718	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	1008	1040	1	1087	Chain	ID=PRO_0000208468;Note=Transcription elongation factor SPT5
SUPT5H	O00267	208	292	273	306	Domain	Note=KOW 1
SUPT5H	O00267	208	292	273	306	Domain	Note=KOW 1
SUPT5H	O00267	208	292	273	306	Domain	Note=KOW 1
SUPT5H	O00267	678	718	704	737	Domain	Note=KOW 5
SUPT5H	O00267	678	718	704	737	Domain	Note=KOW 5
SUPT5H	O00267	678	718	704	737	Domain	Note=KOW 5
SUPT5H	O00267	208	292	176	270	Region	Note=Interaction with SUPT4H1
SUPT5H	O00267	208	292	176	270	Region	Note=Interaction with SUPT4H1
SUPT5H	O00267	208	292	176	270	Region	Note=Interaction with SUPT4H1
SUPT5H	O00267	678	718	681	681	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	686	686	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUPT5H	O00267	678	718	686	686	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUPT5H	O00267	678	718	686	686	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUPT5H	O00267	678	718	696	696	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1 and PRMT5%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1 and PRMT5%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Omega-N-methylarginine%3B by PRMT1 and PRMT5%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Symmetric dimethylarginine%3B by PRMT5%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Symmetric dimethylarginine%3B by PRMT5%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Modified residue	Note=Symmetric dimethylarginine%3B by PRMT5%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	718	718	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55201
SUPT5H	O00267	678	718	718	718	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55201
SUPT5H	O00267	678	718	718	718	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55201
SUPT5H	O00267	1008	1040	1034	1034	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SUPT5H	O00267	1008	1040	1034	1034	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SUPT5H	O00267	1008	1040	1034	1034	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SUPT5H	O00267	1008	1040	1037	1037	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUPT5H	O00267	1008	1040	1037	1037	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUPT5H	O00267	1008	1040	1037	1037	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUPT5H	O00267	678	718	681	681	Mutagenesis	Note=Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-696 and A-698. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Mutagenesis	Note=Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-696 and A-698. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Mutagenesis	Note=Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-696 and A-698. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-696 and K-698. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-696 and K-698. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	681	681	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-696 and K-698. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Mutagenesis	Note=Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-681 and A-698. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Mutagenesis	Note=Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-681 and A-698. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Mutagenesis	Note=Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-681 and A-698. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-681 and K-698. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-681 and K-698. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	696	696	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-681 and K-698. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Mutagenesis	Note=Enhances transcriptional elongation. Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-681 and A-696. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Mutagenesis	Note=Enhances transcriptional elongation. Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-681 and A-696. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Mutagenesis	Note=Enhances transcriptional elongation. Enhances interactions with CDK9 and RNA polymerase II and enhances transcriptional elongation%3B when associated with A-681 and A-696. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-681 and K-696. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-681 and K-696. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	678	718	698	698	Mutagenesis	Note=Increases promoter association and enhances transcriptional elongation%3B when associated with K-681 and K-696. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12718890;Dbxref=PMID:12718890
SUPT5H	O00267	208	292	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	223	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	223	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	223	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	232	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	232	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	232	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	243	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	243	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	243	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	257	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	257	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	257	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	208	292	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT5H	O00267	510	559	509	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DO3
SUPT5H	O00267	510	559	509	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DO3
SUPT5H	O00267	510	559	509	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DO3
SUPT5H	O00267	510	559	517	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DO3
SUPT5H	O00267	510	559	517	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DO3
SUPT5H	O00267	510	559	517	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DO3
SUPT5H	O00267	510	559	539	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	539	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	539	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	543	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	543	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	543	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	547	553	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	547	553	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	547	553	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	555	562	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	555	562	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	510	559	555	562	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHO
SUPT5H	O00267	678	718	708	712	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E70
SUPT5H	O00267	678	718	708	712	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E70
SUPT5H	O00267	678	718	708	712	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E70
SUPT5H	O00267	678	718	716	719	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E70
SUPT5H	O00267	678	718	716	719	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E70
SUPT5H	O00267	678	718	716	719	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E70
SUPT5H	O00267	1008	1040	1001	1008	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1001	1008	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1001	1008	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1011	1016	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1011	1016	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1011	1016	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1017	1020	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1017	1020	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1017	1020	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1021	1026	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1021	1026	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1021	1026	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1027	1029	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1027	1029	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1027	1029	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1030	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1030	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1030	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1040	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1040	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SUPT5H	O00267	1008	1040	1040	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHQ
SLC37A3	Q8NCC5	442	464	1	494	Chain	ID=PRO_0000309278;Note=Sugar phosphate exchanger 3
SLC37A3	Q8NCC5	375	391	1	494	Chain	ID=PRO_0000309278;Note=Sugar phosphate exchanger 3
SLC37A3	Q8NCC5	341	375	1	494	Chain	ID=PRO_0000309278;Note=Sugar phosphate exchanger 3
SLC37A3	Q8NCC5	97	125	1	494	Chain	ID=PRO_0000309278;Note=Sugar phosphate exchanger 3
SLC37A3	Q8NCC5	66	97	1	494	Chain	ID=PRO_0000309278;Note=Sugar phosphate exchanger 3
SLC37A3	Q8NCC5	97	125	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	66	97	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	97	125	113	133	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	341	375	333	353	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	375	391	357	377	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	341	375	357	377	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	375	391	386	406	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	442	464	428	448	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	442	464	452	472	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC37A3	Q8NCC5	442	464	342	443	Alternative sequence	ID=VSP_029113;Note=In isoform 3. GGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQY->VFSVSDPGQARMDVGFLLFHSHDKLYNCVYLAINSEGNILSRAKETGSHIEGVTGARETERTMSATSGPLGLRVCPNLGLSRSSSLILDCQASLNTASHLRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
SLC37A3	Q8NCC5	375	391	342	443	Alternative sequence	ID=VSP_029113;Note=In isoform 3. GGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQY->VFSVSDPGQARMDVGFLLFHSHDKLYNCVYLAINSEGNILSRAKETGSHIEGVTGARETERTMSATSGPLGLRVCPNLGLSRSSSLILDCQASLNTASHLRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
SLC37A3	Q8NCC5	341	375	342	443	Alternative sequence	ID=VSP_029113;Note=In isoform 3. GGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQY->VFSVSDPGQARMDVGFLLFHSHDKLYNCVYLAINSEGNILSRAKETGSHIEGVTGARETERTMSATSGPLGLRVCPNLGLSRSSSLILDCQASLNTASHLRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
SLC37A3	Q8NCC5	375	391	377	392	Alternative sequence	ID=VSP_029114;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC37A3	Q8NCC5	442	464	444	494	Alternative sequence	ID=VSP_029115;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
SPTBN5	Q9NRC6	3483	3528	1	3674	Chain	ID=PRO_0000073466;Note=Spectrin beta chain%2C non-erythrocytic 5
SPTBN5	Q9NRC6	2516	2579	1	3674	Chain	ID=PRO_0000073466;Note=Spectrin beta chain%2C non-erythrocytic 5
SPTBN5	Q9NRC6	1951	2019	1	3674	Chain	ID=PRO_0000073466;Note=Spectrin beta chain%2C non-erythrocytic 5
SPTBN5	Q9NRC6	1563	1630	1	3674	Chain	ID=PRO_0000073466;Note=Spectrin beta chain%2C non-erythrocytic 5
SPTBN5	Q9NRC6	886	937	1	3674	Chain	ID=PRO_0000073466;Note=Spectrin beta chain%2C non-erythrocytic 5
SPTBN5	Q9NRC6	886	937	900	996	Repeat	Note=Spectrin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN5	Q9NRC6	1563	1630	1521	1624	Repeat	Note=Spectrin 9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN5	Q9NRC6	1563	1630	1628	1727	Repeat	Note=Spectrin 10;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN5	Q9NRC6	1951	2019	1944	2046	Repeat	Note=Spectrin 13;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN5	Q9NRC6	2516	2579	2471	2574	Repeat	Note=Spectrin 18;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN5	Q9NRC6	2516	2579	2577	2680	Repeat	Note=Spectrin 19;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN5	Q9NRC6	3483	3528	3422	3488	Repeat	Note=Spectrin 27;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN1	Q01082	100	158	2	2364	Chain	ID=PRO_0000073461;Note=Spectrin beta chain%2C non-erythrocytic 1
SPTBN1	Q01082	394	447	2	2364	Chain	ID=PRO_0000073461;Note=Spectrin beta chain%2C non-erythrocytic 1
SPTBN1	Q01082	1286	1335	2	2364	Chain	ID=PRO_0000073461;Note=Spectrin beta chain%2C non-erythrocytic 1
SPTBN1	Q01082	100	158	54	158	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
SPTBN1	Q01082	394	447	303	411	Repeat	Note=Spectrin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN1	Q01082	394	447	423	525	Repeat	Note=Spectrin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN1	Q01082	1286	1335	1276	1376	Repeat	Note=Spectrin 10;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN1	Q01082	100	158	2	275	Region	Note=Actin-binding
SREBF2	Q12772	240	289	1	1141	Chain	ID=PRO_0000127452;Note=Sterol regulatory element-binding protein 2
SREBF2	Q12772	289	363	1	1141	Chain	ID=PRO_0000127452;Note=Sterol regulatory element-binding protein 2
SREBF2	Q12772	969	1031	1	1141	Chain	ID=PRO_0000127452;Note=Sterol regulatory element-binding protein 2
SREBF2	Q12772	240	289	1	484	Chain	ID=PRO_0000314033;Note=Processed sterol regulatory element-binding protein 2
SREBF2	Q12772	289	363	1	484	Chain	ID=PRO_0000314033;Note=Processed sterol regulatory element-binding protein 2
SREBF2	Q12772	240	289	1	479	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SREBF2	Q12772	289	363	1	479	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SREBF2	Q12772	969	1031	555	1139	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SREBF2	Q12772	289	363	330	380	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
SREBF2	Q12772	240	289	237	491	Region	Note=Interaction with LMNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
SREBF2	Q12772	289	363	237	491	Region	Note=Interaction with LMNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
SREBF2	Q12772	240	289	125	244	Compositional bias	Note=Gln-rich
SREBF2	Q12772	240	289	273	275	Alternative sequence	ID=VSP_054283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SREBF2	Q12772	969	1031	685	1141	Alternative sequence	ID=VSP_054285;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SREBF2	Q12772	240	289	273	273	Natural variant	ID=VAR_036394;Note=In a breast cancer sample%3B somatic mutation. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SREBF2	Q12772	289	363	347	347	Natural variant	ID=VAR_036395;Note=In a breast cancer sample%3B somatic mutation. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SREBF2	Q12772	289	363	346	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UKL
SRGAP1	Q7Z6B7	224	267	1	1085	Chain	ID=PRO_0000056765;Note=SLIT-ROBO Rho GTPase-activating protein 1
SRGAP1	Q7Z6B7	224	267	19	314	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
CTTN	Q14247	0	29	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	152	189	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	189	226	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	226	263	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	263	300	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	392	422	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	481	505	1	550	Chain	ID=PRO_0000072189;Note=Src substrate cortactin
CTTN	Q14247	152	189	117	153	Repeat	Note=Cortactin 2
CTTN	Q14247	152	189	154	190	Repeat	Note=Cortactin 3
CTTN	Q14247	189	226	154	190	Repeat	Note=Cortactin 3
CTTN	Q14247	189	226	191	227	Repeat	Note=Cortactin 4
CTTN	Q14247	226	263	191	227	Repeat	Note=Cortactin 4
CTTN	Q14247	226	263	228	264	Repeat	Note=Cortactin 5
CTTN	Q14247	263	300	228	264	Repeat	Note=Cortactin 5
CTTN	Q14247	263	300	265	301	Repeat	Note=Cortactin 6
CTTN	Q14247	481	505	492	550	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
CTTN	Q14247	392	422	348	401	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CTTN	Q14247	152	189	161	161	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60598
CTTN	Q14247	152	189	181	181	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60598
CTTN	Q14247	189	226	198	198	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CTTN	Q14247	226	263	235	235	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CTTN	Q14247	226	263	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
CTTN	Q14247	263	300	272	272	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CTTN	Q14247	263	300	295	295	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60598
CTTN	Q14247	392	422	399	399	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
CTTN	Q14247	392	422	401	401	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
CTTN	Q14247	392	422	405	405	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:15144186,ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:15144186,PMID:16964243,PMID:17081983,PMID:18088087,PMID:18220336,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
CTTN	Q14247	392	422	411	411	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CTTN	Q14247	392	422	417	417	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CTTN	Q14247	392	422	418	418	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
CTTN	Q14247	392	422	421	421	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:19690332;Dbxref=PMID:18088087,PMID:19690332
CTTN	Q14247	481	505	486	486	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15561106,ECO:0000269|PubMed:17959782;Dbxref=PMID:15561106,PMID:17959782
CTTN	Q14247	481	505	489	489	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60598
CTTN	Q14247	152	189	181	181	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
CTTN	Q14247	152	189	181	181	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CTTN	Q14247	189	226	218	218	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
CTTN	Q14247	263	300	295	295	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CTTN	Q14247	263	300	264	300	Alternative sequence	ID=VSP_043120;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CTTN	Q14247	481	505	495	495	Sequence conflict	Note=I->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTTN	Q14247	481	505	497	499	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D1X
SRP72	O76094	275	319	2	671	Chain	ID=PRO_0000135234;Note=Signal recognition particle subunit SRP72
SRP72	O76094	319	362	2	671	Chain	ID=PRO_0000135234;Note=Signal recognition particle subunit SRP72
SRP72	O76094	275	319	215	275	Alternative sequence	ID=VSP_045576;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SREK1IP1	Q8N9Q2	20	68	1	155	Chain	ID=PRO_0000311922;Note=Protein SREK1IP1
SREK1IP1	Q8N9Q2	20	68	13	30	Zinc finger	Note=CCHC-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047
SREK1IP1	Q8N9Q2	20	68	52	52	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
SRPX2	O60687	118	177	24	465	Chain	ID=PRO_0000274525;Note=Sushi repeat-containing protein SRPX2
SRPX2	O60687	118	177	69	119	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SRPX2	O60687	118	177	120	178	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SRPX2	O60687	118	177	177	261	Domain	Note=HYR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00113
SRPX2	O60687	118	177	122	163	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SRPX2	O60687	118	177	149	176	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
STAMBPL1	Q96FJ0	301	347	1	436	Chain	ID=PRO_0000194874;Note=AMSH-like protease
STAMBPL1	Q96FJ0	301	347	1	436	Chain	ID=PRO_0000194874;Note=AMSH-like protease
STAMBPL1	Q96FJ0	301	347	269	397	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
STAMBPL1	Q96FJ0	301	347	269	397	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
STAMBPL1	Q96FJ0	301	347	347	360	Motif	Note=JAMM motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
STAMBPL1	Q96FJ0	301	347	347	360	Motif	Note=JAMM motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
STAMBPL1	Q96FJ0	301	347	347	347	Metal binding	Note=Zinc 1%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
STAMBPL1	Q96FJ0	301	347	347	347	Metal binding	Note=Zinc 1%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
STAMBPL1	Q96FJ0	301	347	329	329	Mutagenesis	Note=3-fold decrease in substrate affinity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18758443;Dbxref=PMID:18758443
STAMBPL1	Q96FJ0	301	347	329	329	Mutagenesis	Note=3-fold decrease in substrate affinity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18758443;Dbxref=PMID:18758443
STAMBPL1	Q96FJ0	301	347	332	332	Mutagenesis	Note=12-fold decrease in substrate affinity%2C little effect on catalytic activity. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18758443;Dbxref=PMID:18758443
STAMBPL1	Q96FJ0	301	347	332	332	Mutagenesis	Note=12-fold decrease in substrate affinity%2C little effect on catalytic activity. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18758443;Dbxref=PMID:18758443
STAMBPL1	Q96FJ0	301	347	294	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	294	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	305	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	305	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	316	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	316	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	322	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	322	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	328	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	328	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	341	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STAMBPL1	Q96FJ0	301	347	341	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZNR
STK24	Q9Y6E0	363	386	1	443	Chain	ID=PRO_0000086711;Note=Serine/threonine-protein kinase 24
STK24	Q9Y6E0	211	273	1	443	Chain	ID=PRO_0000086711;Note=Serine/threonine-protein kinase 24
STK24	Q9Y6E0	103	122	1	443	Chain	ID=PRO_0000086711;Note=Serine/threonine-protein kinase 24
STK24	Q9Y6E0	211	273	1	325	Chain	ID=PRO_0000413618;Note=Serine/threonine-protein kinase 24 36 kDa subunit
STK24	Q9Y6E0	103	122	1	325	Chain	ID=PRO_0000413618;Note=Serine/threonine-protein kinase 24 36 kDa subunit
STK24	Q9Y6E0	363	386	326	443	Chain	ID=PRO_0000413619;Note=Serine/threonine-protein kinase 24 12 kDa subunit
STK24	Q9Y6E0	211	273	36	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK24	Q9Y6E0	103	122	36	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK24	Q9Y6E0	103	122	112	114	Nucleotide binding	Note=ATP
STK24	Q9Y6E0	363	386	335	386	Motif	Note=Nuclear export signal (NES)
STK24	Q9Y6E0	103	122	97	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	103	122	106	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	103	122	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7J
STK24	Q9Y6E0	103	122	119	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	211	273	211	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	211	273	230	233	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	211	273	236	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	211	273	253	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QML
STK24	Q9Y6E0	211	273	257	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STK24	Q9Y6E0	211	273	271	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A7I
STAP1	Q9ULZ2	102	121	1	295	Chain	ID=PRO_0000072237;Note=Signal-transducing adaptor protein 1
STAP1	Q9ULZ2	177	219	1	295	Chain	ID=PRO_0000072237;Note=Signal-transducing adaptor protein 1
STAP1	Q9ULZ2	102	121	1	295	Chain	ID=PRO_0000072237;Note=Signal-transducing adaptor protein 1
STAP1	Q9ULZ2	177	219	1	295	Chain	ID=PRO_0000072237;Note=Signal-transducing adaptor protein 1
STAP1	Q9ULZ2	102	121	25	121	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
STAP1	Q9ULZ2	102	121	25	121	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
STAP1	Q9ULZ2	177	219	177	280	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAP1	Q9ULZ2	177	219	177	280	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAP1	Q9ULZ2	102	121	99	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1F
STAP1	Q9ULZ2	102	121	99	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1F
STAP1	Q9ULZ2	102	121	106	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1F
STAP1	Q9ULZ2	102	121	106	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X1F
STAP1	Q9ULZ2	177	219	184	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	184	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	199	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	199	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	208	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	208	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	219	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STAP1	Q9ULZ2	177	219	219	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MAZ
STK25	O00506	195	257	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	87	106	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	10	87	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	195	257	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	87	106	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	10	87	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	195	257	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	87	106	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	10	87	1	426	Chain	ID=PRO_0000086713;Note=Serine/threonine-protein kinase 25
STK25	O00506	195	257	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	87	106	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	195	257	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	87	106	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	195	257	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	87	106	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	20	270	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	26	34	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	26	34	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	26	34	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	49	49	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	49	49	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	10	87	49	49	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK25	O00506	87	106	1	94	Alternative sequence	ID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	1	94	Alternative sequence	ID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	87	106	1	94	Alternative sequence	ID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	1	94	Alternative sequence	ID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	87	106	1	94	Alternative sequence	ID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	1	94	Alternative sequence	ID=VSP_054683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	87	106	11	87	Alternative sequence	ID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	11	87	Alternative sequence	ID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	87	106	11	87	Alternative sequence	ID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	11	87	Alternative sequence	ID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	87	106	11	87	Alternative sequence	ID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	11	87	Alternative sequence	ID=VSP_054397;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK25	O00506	10	87	64	64	Natural variant	ID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
STK25	O00506	10	87	64	64	Natural variant	ID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
STK25	O00506	10	87	64	64	Natural variant	ID=VAR_051674;Note=Q->H;Dbxref=dbSNP:rs34341643
STK25	O00506	10	87	49	49	Mutagenesis	Note=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
STK25	O00506	10	87	49	49	Mutagenesis	Note=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
STK25	O00506	10	87	49	49	Mutagenesis	Note=Loss of kinase activity and autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037601;Dbxref=PMID:15037601
STK25	O00506	10	87	8	10	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	8	10	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	8	10	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	16	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	16	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	16	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	20	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	20	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	20	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	30	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	30	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	30	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	40	42	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	40	42	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	40	42	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	45	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	45	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	45	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	53	56	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	53	56	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	53	56	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	60	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	10	87	81	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	90	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	90	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	90	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	103	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	103	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	87	106	103	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	195	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	195	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	195	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	214	217	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	214	217	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	214	217	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	241	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	241	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	241	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STK25	O00506	195	257	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIK
STAT3	P40763	629	700	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	455	488	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	427	455	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	350	369	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	124	156	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	91	124	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	629	700	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	455	488	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	427	455	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	350	369	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	124	156	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	91	124	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	629	700	580	670	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT3	P40763	629	700	580	670	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT3	P40763	124	156	150	162	Motif	Note=Essential for nuclear import
STAT3	P40763	124	156	150	162	Motif	Note=Essential for nuclear import
STAT3	P40763	629	700	631	631	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	631	631	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	631	631	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	631	631	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	124	156	143	143	Natural variant	ID=VAR_018679;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878478
STAT3	P40763	124	156	143	143	Natural variant	ID=VAR_018679;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878478
STAT3	P40763	427	455	437	437	Natural variant	ID=VAR_037372;Note=In AD-HIES%3B loss of function. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17676033;Dbxref=PMID:17676033
STAT3	P40763	427	455	437	437	Natural variant	ID=VAR_037372;Note=In AD-HIES%3B loss of function. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17676033;Dbxref=PMID:17676033
STAT3	P40763	455	488	463	463	Natural variant	ID=VAR_037373;Note=In AD-HIES%3B loss of function. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17676033,ECO:0000269|PubMed:17881745;Dbxref=PMID:17676033,PMID:17881745
STAT3	P40763	455	488	463	463	Natural variant	ID=VAR_037373;Note=In AD-HIES%3B loss of function. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17676033,ECO:0000269|PubMed:17881745;Dbxref=PMID:17676033,PMID:17881745
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037378;Note=In AD-HIES. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037378;Note=In AD-HIES. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037379;Note=In AD-HIES%3B reduced DNA-binding ability. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs113994139,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037379;Note=In AD-HIES%3B reduced DNA-binding ability. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs113994139,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	644	644	Natural variant	ID=VAR_037380;Note=In AD-HIES. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	644	644	Natural variant	ID=VAR_037380;Note=In AD-HIES. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	646	646	Natural variant	ID=VAR_071886;Note=In ADMIO1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777649,PMID:25038750
STAT3	P40763	629	700	646	646	Natural variant	ID=VAR_071886;Note=In ADMIO1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777649,PMID:25038750
STAT3	P40763	629	700	657	657	Natural variant	ID=VAR_037381;Note=In AD-HIES%3B reduced DNA-binding ability. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs193922721,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	657	657	Natural variant	ID=VAR_037381;Note=In AD-HIES%3B reduced DNA-binding ability. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs193922721,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	658	658	Natural variant	ID=VAR_071887;Note=In ADMIO1. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777650,PMID:25038750
STAT3	P40763	629	700	658	658	Natural variant	ID=VAR_071887;Note=In ADMIO1. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777650,PMID:25038750
STAT3	P40763	427	455	434	435	Mutagenesis	Note=Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. EE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344214,ECO:0000269|PubMed:25476455;Dbxref=PMID:17344214,PMID:25476455
STAT3	P40763	427	455	434	435	Mutagenesis	Note=Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. EE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344214,ECO:0000269|PubMed:25476455;Dbxref=PMID:17344214,PMID:25476455
STAT3	P40763	124	156	133	133	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	124	156	133	133	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	455	488	460	460	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	455	488	460	460	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	652	652	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	652	652	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	667	667	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	667	667	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK39	Q9UEW8	414	435	1	545	Chain	ID=PRO_0000086722;Note=STE20/SPS1-related proline-alanine-rich protein kinase
STK39	Q9UEW8	246	280	1	545	Chain	ID=PRO_0000086722;Note=STE20/SPS1-related proline-alanine-rich protein kinase
STK39	Q9UEW8	246	280	63	337	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK39	Q9UEW8	414	435	310	536	Region	Note=Interaction with RELT;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1W9
STK39	Q9UEW8	414	435	416	416	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK4	Q13043	120	175	1	487	Chain	ID=PRO_0000086691;Note=Serine/threonine-protein kinase 4
STK4	Q13043	231	277	1	487	Chain	ID=PRO_0000086691;Note=Serine/threonine-protein kinase 4
STK4	Q13043	120	175	1	326	Chain	ID=PRO_0000413735;Note=Serine/threonine-protein kinase 4 37kDa subunit
STK4	Q13043	231	277	1	326	Chain	ID=PRO_0000413735;Note=Serine/threonine-protein kinase 4 37kDa subunit
STK4	Q13043	120	175	30	281	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK4	Q13043	231	277	30	281	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK4	Q13043	120	175	149	149	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK4	Q13043	231	277	265	265	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
STK4	Q13043	120	175	162	162	Natural variant	ID=VAR_041123;Note=H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55850759,PMID:17344846
STK4	Q13043	120	175	175	175	Mutagenesis	Note=No effect on activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15109305;Dbxref=PMID:15109305
STK4	Q13043	120	175	123	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	120	175	152	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	120	175	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	120	175	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	231	277	229	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	231	277	247	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	231	277	252	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	231	277	266	268	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STK4	Q13043	231	277	272	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COM
STX1A	Q16623	226	263	1	288	Chain	ID=PRO_0000210186;Note=Syntaxin-1A
STX1A	Q16623	226	263	1	265	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX1A	Q16623	226	263	192	254	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
STX1A	Q16623	226	263	227	288	Alternative sequence	ID=VSP_006338;Note=In isoform 2. GEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA->PQGAFLKSCPEPQPNREEGALWSSGAPGPAGRDD;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12586365,ECO:0000303|PubMed:9003414;Dbxref=PMID:12586365,PMID:9003414
STX1A	Q16623	226	263	227	288	Alternative sequence	ID=VSP_006339;Note=In isoform 3. GEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA->TMWRGPCLTPRRPSSTRARRAGRKS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STX8	Q9UNK0	180	214	1	236	Chain	ID=PRO_0000210217;Note=Syntaxin-8
STX8	Q9UNK0	149	180	1	236	Chain	ID=PRO_0000210217;Note=Syntaxin-8
STX8	Q9UNK0	180	214	1	215	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX8	Q9UNK0	149	180	1	215	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX8	Q9UNK0	180	214	145	207	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
STX8	Q9UNK0	149	180	145	207	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
STX8	Q9UNK0	149	180	160	160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88983
STX10	O60499	121	157	2	249	Chain	ID=PRO_0000210220;Note=Syntaxin-10
STX10	O60499	100	121	2	249	Chain	ID=PRO_0000210220;Note=Syntaxin-10
STX10	O60499	121	157	2	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX10	O60499	100	121	2	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX10	O60499	121	157	157	219	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
STX10	O60499	100	121	108	108	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
STX10	O60499	100	121	110	110	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
STX10	O60499	121	157	134	134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
STX10	O60499	121	157	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
STX10	O60499	121	157	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
STX10	O60499	121	157	76	124	Alternative sequence	ID=VSP_006347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STX10	O60499	100	121	76	124	Alternative sequence	ID=VSP_006347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STX10	O60499	100	121	82	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DND
FARSB	Q9NSD9	487	539	1	589	Chain	ID=PRO_0000127016;Note=Phenylalanine--tRNA ligase beta subunit
FARSB	Q9NSD9	417	448	1	589	Chain	ID=PRO_0000127016;Note=Phenylalanine--tRNA ligase beta subunit
FARSB	Q9NSD9	417	448	416	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	420	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	425	427	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	438	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	445	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	448	450	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	490	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	508	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	528	531	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	532	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
IARS	P41252	1136	1184	1	1262	Chain	ID=PRO_0000098597;Note=Isoleucine--tRNA ligase%2C cytoplasmic
IARS	P41252	1094	1136	1	1262	Chain	ID=PRO_0000098597;Note=Isoleucine--tRNA ligase%2C cytoplasmic
IARS	P41252	502	566	1	1262	Chain	ID=PRO_0000098597;Note=Isoleucine--tRNA ligase%2C cytoplasmic
IARS	P41252	1136	1184	1174	1174	Natural variant	ID=VAR_077058;Note=In GRIDHH. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27426735;Dbxref=dbSNP:rs886037873,PMID:27426735
IARS	P41252	1136	1184	1182	1182	Natural variant	ID=VAR_057952;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs556155,PMID:17974005
SYNJ2BP	P57105	67	99	1	145	Chain	ID=PRO_0000072383;Note=Synaptojanin-2-binding protein
SYNJ2BP	P57105	67	99	1	117	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNJ2BP	P57105	67	99	13	100	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SYNJ2BP	P57105	67	99	68	68	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYNJ2BP	P57105	67	99	64	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIK
SYNJ2BP	P57105	67	99	78	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIK
SYNJ2BP	P57105	67	99	90	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JIK
KARS	Q15046	265	305	2	597	Chain	ID=PRO_0000152765;Note=Lysine--tRNA ligase
KARS	Q15046	265	305	277	277	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18272479,ECO:0000269|PubMed:26074468;Dbxref=PMID:18272479,PMID:26074468
KARS	Q15046	265	305	301	301	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18272479,ECO:0000269|PubMed:23159739,ECO:0000269|PubMed:26074468;Dbxref=PMID:18272479,PMID:23159739,PMID:26074468
KARS	Q15046	265	305	274	274	Natural variant	ID=VAR_064912;Note=In CMTRIB. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20920668;Dbxref=dbSNP:rs146955132,PMID:20920668
KARS	Q15046	265	305	270	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YCU
KARS	Q15046	265	305	277	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJU
KARS	Q15046	265	305	284	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YCU
KARS	Q15046	265	305	288	291	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YCU
KARS	Q15046	265	305	292	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YCU
KARS	Q15046	265	305	301	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YCU
TNFRSF13B	O14836	20	66	1	293	Chain	ID=PRO_0000058931;Note=Tumor necrosis factor receptor superfamily member 13B
TNFRSF13B	O14836	20	66	1	165	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF13B	O14836	20	66	33	67	Repeat	Note=TNFR-Cys 1
TNFRSF13B	O14836	20	66	34	47	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF13B	O14836	20	66	50	62	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF13B	O14836	20	66	54	66	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF13B	O14836	20	66	21	67	Alternative sequence	ID=VSP_013798;Note=In isoform 2. FPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCR->W;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
TNFRSF13B	O14836	20	66	56	56	Natural variant	ID=VAR_064758;Note=Found in a renal cell carcinoma sample%3B somatic mutation. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752
THRAP3	Q9Y2W1	46	346	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
THRAP3	Q9Y2W1	834	882	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
THRAP3	Q9Y2W1	46	346	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
THRAP3	Q9Y2W1	834	882	2	955	Chain	ID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
THRAP3	Q9Y2W1	46	346	2	190	Region	Note=Required for mRNA splicing activation
THRAP3	Q9Y2W1	46	346	2	190	Region	Note=Required for mRNA splicing activation
THRAP3	Q9Y2W1	834	882	359	955	Region	Note=Required for mRNA decay activity
THRAP3	Q9Y2W1	834	882	359	955	Region	Note=Required for mRNA decay activity
THRAP3	Q9Y2W1	46	346	7	339	Compositional bias	Note=Ser-rich
THRAP3	Q9Y2W1	46	346	7	339	Compositional bias	Note=Ser-rich
THRAP3	Q9Y2W1	46	346	12	161	Compositional bias	Note=Arg-rich
THRAP3	Q9Y2W1	46	346	12	161	Compositional bias	Note=Arg-rich
THRAP3	Q9Y2W1	46	346	66	66	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	66	66	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	101	101	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	101	101	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	108	108	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	108	108	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THRAP3	Q9Y2W1	46	346	220	220	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THRAP3	Q9Y2W1	46	346	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
THRAP3	Q9Y2W1	46	346	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
THRAP3	Q9Y2W1	46	346	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
THRAP3	Q9Y2W1	46	346	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
THRAP3	Q9Y2W1	46	346	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
THRAP3	Q9Y2W1	46	346	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
THRAP3	Q9Y2W1	46	346	240	240	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
THRAP3	Q9Y2W1	46	346	240	240	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
THRAP3	Q9Y2W1	46	346	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.5;Dbxref=PMID:16964243,PMID:17081983,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19367720,PMID:20068231,PMID:21406692,PMID:23186163
THRAP3	Q9Y2W1	46	346	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.5;Dbxref=PMID:16964243,PMID:17081983,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19367720,PMID:20068231,PMID:21406692,PMID:23186163
THRAP3	Q9Y2W1	46	346	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18220336,PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18220336,PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	252	252	Modified residue	Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	252	252	Modified residue	Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
THRAP3	Q9Y2W1	46	346	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18220336,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18220336,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163
THRAP3	Q9Y2W1	46	346	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163
THRAP3	Q9Y2W1	46	346	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|Ref.5;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|Ref.5;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
THRAP3	Q9Y2W1	46	346	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THRAP3	Q9Y2W1	46	346	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THRAP3	Q9Y2W1	46	346	324	324	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	46	346	324	324	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	46	346	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THRAP3	Q9Y2W1	46	346	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THRAP3	Q9Y2W1	46	346	328	328	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	46	346	328	328	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	46	346	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
THRAP3	Q9Y2W1	46	346	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
THRAP3	Q9Y2W1	46	346	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	46	346	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	834	882	845	845	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	834	882	845	845	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
THRAP3	Q9Y2W1	834	882	874	874	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
THRAP3	Q9Y2W1	834	882	874	874	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
THRAP3	Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
THRAP3	Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
THRAP3	Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	202	202	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	215	215	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	215	215	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	221	221	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	221	221	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	252	252	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	333	333	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	346	346	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	346	346	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	834	882	876	876	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	834	882	876	876	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	834	882	879	879	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	834	882	879	879	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
THRAP3	Q9Y2W1	46	346	201	201	Natural variant	ID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
THRAP3	Q9Y2W1	46	346	201	201	Natural variant	ID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
TRA2B	P62995	241	260	2	288	Chain	ID=PRO_0000081983;Note=Transformer-2 protein homolog beta
TRA2B	P62995	213	240	2	288	Chain	ID=PRO_0000081983;Note=Transformer-2 protein homolog beta
TRA2B	P62995	111	174	2	288	Chain	ID=PRO_0000081983;Note=Transformer-2 protein homolog beta
TRA2B	P62995	111	174	118	196	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
TRA2B	P62995	213	240	193	230	Region	Note=Linker
TRA2B	P62995	111	174	31	113	Compositional bias	Note=Arg/Ser-rich (RS1 domain)
TRA2B	P62995	241	260	231	287	Compositional bias	Note=Arg/Ser-rich (RS2 domain)
TRA2B	P62995	213	240	231	287	Compositional bias	Note=Arg/Ser-rich (RS2 domain)
TRA2B	P62995	213	240	215	215	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRA2B	P62995	213	240	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRA2B	P62995	241	260	241	241	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TRA2B	P62995	241	260	241	241	Modified residue	Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:15782174,ECO:0000269|Ref.7;Dbxref=PMID:15782174
TRA2B	P62995	241	260	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TRA2B	P62995	241	260	39	288	Alternative sequence	ID=VSP_005899;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9212162;Dbxref=PMID:9212162
TRA2B	P62995	213	240	39	288	Alternative sequence	ID=VSP_005899;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9212162;Dbxref=PMID:9212162
TRA2B	P62995	111	174	39	288	Alternative sequence	ID=VSP_005899;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9212162;Dbxref=PMID:9212162
TRA2B	P62995	111	174	116	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQC
TRA2B	P62995	111	174	120	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQC
TRA2B	P62995	111	174	131	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQC
TRA2B	P62995	111	174	144	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQC
TRA2B	P62995	111	174	153	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQC
TRA2B	P62995	111	174	169	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQC
TRAF3	Q13114	190	217	1	568	Chain	ID=PRO_0000056401;Note=TNF receptor-associated factor 3
TRAF3	Q13114	217	242	1	568	Chain	ID=PRO_0000056401;Note=TNF receptor-associated factor 3
TRAF3	Q13114	273	320	1	568	Chain	ID=PRO_0000056401;Note=TNF receptor-associated factor 3
TRAF3	Q13114	190	217	1	568	Chain	ID=PRO_0000056401;Note=TNF receptor-associated factor 3
TRAF3	Q13114	217	242	1	568	Chain	ID=PRO_0000056401;Note=TNF receptor-associated factor 3
TRAF3	Q13114	273	320	1	568	Chain	ID=PRO_0000056401;Note=TNF receptor-associated factor 3
TRAF3	Q13114	190	217	135	190	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF3	Q13114	190	217	135	190	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF3	Q13114	190	217	191	249	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF3	Q13114	217	242	191	249	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF3	Q13114	190	217	191	249	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF3	Q13114	217	242	191	249	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF3	Q13114	273	320	267	338	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3	Q13114	273	320	267	338	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF3	Q13114	190	217	191	273	Alternative sequence	ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF3	Q13114	217	242	191	273	Alternative sequence	ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF3	Q13114	273	320	191	273	Alternative sequence	ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF3	Q13114	190	217	191	273	Alternative sequence	ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF3	Q13114	217	242	191	273	Alternative sequence	ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF3	Q13114	273	320	191	273	Alternative sequence	ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF3	Q13114	217	242	218	242	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAF3	Q13114	217	242	218	242	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAF7	Q6Q0C0	77	116	1	670	Chain	ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7
TRAF7	Q6Q0C0	116	147	1	670	Chain	ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7
TRAF7	Q6Q0C0	501	542	1	670	Chain	ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7
TRAF7	Q6Q0C0	582	626	1	670	Chain	ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7
TRAF7	Q6Q0C0	501	542	477	513	Repeat	Note=WD 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF7	Q6Q0C0	501	542	515	554	Repeat	Note=WD 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF7	Q6Q0C0	582	626	557	594	Repeat	Note=WD 5;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF7	Q6Q0C0	582	626	597	638	Repeat	Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF7	Q6Q0C0	116	147	131	165	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
TRAF7	Q6Q0C0	77	116	88	88	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TRAF7	Q6Q0C0	77	116	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NARS	O43776	461	505	1	548	Chain	ID=PRO_0000176496;Note=Asparagine--tRNA ligase%2C cytoplasmic
NARS	O43776	164	193	1	548	Chain	ID=PRO_0000176496;Note=Asparagine--tRNA ligase%2C cytoplasmic
NARS	O43776	84	114	1	548	Chain	ID=PRO_0000176496;Note=Asparagine--tRNA ligase%2C cytoplasmic
NARS	O43776	461	505	482	482	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BP47
NARS	O43776	461	505	490	490	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BP47
NARS	O43776	164	193	141	173	Alternative sequence	ID=VSP_056201;Note=In isoform 2. GKNLMFLVLRDGTGYLQCVLADELCQCYNGVLL->VSVLQWSSLVHGEQCCSVWNAKSYPKGQAGSRW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NARS	O43776	461	505	174	547	Alternative sequence	ID=VSP_056202;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NARS	O43776	164	193	174	547	Alternative sequence	ID=VSP_056202;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NARS	O43776	164	193	163	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	164	193	168	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	164	193	178	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	455	466	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	467	469	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	470	478	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	482	492	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	497	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	500	503	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
NARS	O43776	461	505	504	506	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XIX
TRAP1	Q12931	29	82	1	59	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
TRAP1	Q12931	110	157	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
TRAP1	Q12931	29	82	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
TRAP1	Q12931	110	157	119	119	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	158	158	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	171	171	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5XHZ0
TRAP1	Q12931	157	181	174	174	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5XHZ0
TRAP1	Q12931	29	82	30	82	Alternative sequence	ID=VSP_055061;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAP1	Q12931	29	82	53	53	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAP1	Q12931	110	157	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	111	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	149	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	157	181	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	157	181	165	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	157	181	179	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRDN	Q13061	663	675	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	623	635	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	557	573	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	522	532	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	490	503	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	456	473	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	368	378	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	284	310	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	264	284	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	141	161	1	729	Chain	ID=PRO_0000065626;Note=Triadin
TRDN	Q13061	663	675	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	623	635	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	557	573	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	522	532	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	490	503	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	456	473	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	368	378	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	284	310	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	264	284	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	141	161	69	729	Topological domain	Note=Lumenal
TRDN	Q13061	264	284	270	270	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q28820
TRDN	Q13061	663	675	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	623	635	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	557	573	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	522	532	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	490	503	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	456	473	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	368	378	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	284	310	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	264	284	168	729	Alternative sequence	ID=VSP_045562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	284	310	265	284	Alternative sequence	ID=VSP_045563;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	264	284	265	284	Alternative sequence	ID=VSP_045563;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	663	675	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	623	635	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	557	573	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	522	532	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	490	503	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	456	473	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	368	378	318	729	Alternative sequence	ID=VSP_045565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRDN	Q13061	456	473	470	470	Natural variant	ID=VAR_057012;Note=L->M;Dbxref=dbSNP:rs6569336
TREM2	Q9NZC2	13	130	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TREM2	Q9NZC2	13	130	19	230	Chain	ID=PRO_0000014987;Note=Triggering receptor expressed on myeloid cells 2
TREM2	Q9NZC2	13	130	19	174	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TREM2	Q9NZC2	13	130	29	112	Domain	Note=Ig-like V-type
TREM2	Q9NZC2	13	130	20	20	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TREM2	Q9NZC2	13	130	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5ELI,ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	36	110	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5ELI,ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	51	60	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5ELI,ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	96	96	Natural variant	ID=VAR_061329;Note=Does not change protein structure%3B changes protein stability%3B increases binding to THP-1 cells. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=dbSNP:rs2234253,PMID:27995897
TREM2	Q9NZC2	13	130	96	96	Natural variant	ID=VAR_061330;Note=T->R;Dbxref=dbSNP:rs2234253
TREM2	Q9NZC2	13	130	38	38	Mutagenesis	Note=Increases protein aggregation%3B decreases cell membrane localization%3B protein is secreted. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	47	47	Mutagenesis	Note=Decreases binding to NA2 and THP-1 cells%3B induces small conformational change%3B no change in thermal stability%3B no effect on cell membrane localization. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	62	62	Mutagenesis	Note=Does not change protein structure%3B no change in thermal stability%3B no effect on cell membrane localization. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	66	66	Mutagenesis	Note=Increases protein aggregation%3B decreases cell membrane localization%3B protein is secreted. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	68	68	Mutagenesis	Note=No effect on cell membrane localization. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	76	76	Mutagenesis	Note=Decreases binding to THP-1 cells. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	77	77	Mutagenesis	Note=Decreases binding to THP-1 cells. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	87	87	Mutagenesis	Note=No effect on cell membrane localization. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	126	126	Mutagenesis	Note=Increases protein aggregation%3B decreases cell membrane localization%3B protein is secreted. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995897;Dbxref=PMID:27995897
TREM2	Q9NZC2	13	130	21	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	40	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	48	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	55	57	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	60	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	69	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	77	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD7
TREM2	Q9NZC2	13	130	83	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	88	91	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	92	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	106	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
TREM2	Q9NZC2	13	130	117	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UD8
QARS	P47897	717	759	2	775	Chain	ID=PRO_0000195860;Note=Glutamine--tRNA ligase
QARS	P47897	621	652	2	775	Chain	ID=PRO_0000195860;Note=Glutamine--tRNA ligase
QARS	P47897	463	508	2	775	Chain	ID=PRO_0000195860;Note=Glutamine--tRNA ligase
QARS	P47897	432	462	2	775	Chain	ID=PRO_0000195860;Note=Glutamine--tRNA ligase
QARS	P47897	210	234	2	775	Chain	ID=PRO_0000195860;Note=Glutamine--tRNA ligase
QARS	P47897	463	508	486	487	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00962
QARS	P47897	463	508	494	496	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00962
QARS	P47897	463	508	493	497	Motif	Note="KMSKS" region;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26869582;Dbxref=PMID:26869582
QARS	P47897	432	462	438	438	Binding site	Note=L-glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00962
QARS	P47897	432	462	457	457	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00962
QARS	P47897	463	508	495	495	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
QARS	P47897	210	234	220	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	210	234	226	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	432	462	433	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	432	462	438	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	432	462	452	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	463	508	464	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	463	508	480	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	463	508	487	489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	463	508	496	504	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	463	508	507	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	621	652	647	650	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	720	722	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	725	728	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	732	734	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	740	743	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	744	746	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	747	751	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
QARS	P47897	717	759	757	759	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YE6
TRHDE	Q9UKU6	483	529	1	1024	Chain	ID=PRO_0000095118;Note=Thyrotropin-releasing hormone-degrading ectoenzyme
TRHDE	Q9UKU6	551	573	1	1024	Chain	ID=PRO_0000095118;Note=Thyrotropin-releasing hormone-degrading ectoenzyme
TRHDE	Q9UKU6	483	529	62	1024	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRHDE	Q9UKU6	551	573	62	1024	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRHDE	Q9UKU6	483	529	527	527	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
RARS2	Q5T160	504	528	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	472	503	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	293	324	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	204	257	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	150	178	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	71	99	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	293	324	322	322	Binding site	Note=L-arginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54136
MID1	O15344	428	482	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	252	288	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	220	252	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	428	482	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	252	288	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	220	252	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	428	482	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	252	288	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	220	252	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	428	482	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	252	288	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	220	252	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	428	482	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	252	288	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	220	252	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	428	482	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	252	288	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	220	252	1	667	Chain	ID=PRO_0000056227;Note=E3 ubiquitin-protein ligase Midline-1
MID1	O15344	428	482	381	484	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MID1	O15344	428	482	381	484	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MID1	O15344	428	482	381	484	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MID1	O15344	428	482	381	484	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MID1	O15344	428	482	381	484	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MID1	O15344	428	482	381	484	Domain	Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
MID1	O15344	428	482	482	659	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
MID1	O15344	428	482	482	659	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
MID1	O15344	428	482	482	659	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
MID1	O15344	428	482	482	659	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
MID1	O15344	428	482	482	659	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
MID1	O15344	428	482	482	659	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
MID1	O15344	252	288	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	220	252	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	252	288	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	220	252	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	252	288	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	220	252	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	252	288	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	220	252	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	252	288	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	220	252	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	252	288	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	220	252	205	264	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID1	O15344	252	288	266	266	Natural variant	ID=VAR_013758;Note=In GBBB1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718340;Dbxref=PMID:9718340
MID1	O15344	252	288	266	266	Natural variant	ID=VAR_013758;Note=In GBBB1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718340;Dbxref=PMID:9718340
MID1	O15344	252	288	266	266	Natural variant	ID=VAR_013758;Note=In GBBB1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718340;Dbxref=PMID:9718340
MID1	O15344	252	288	266	266	Natural variant	ID=VAR_013758;Note=In GBBB1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718340;Dbxref=PMID:9718340
MID1	O15344	252	288	266	266	Natural variant	ID=VAR_013758;Note=In GBBB1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718340;Dbxref=PMID:9718340
MID1	O15344	252	288	266	266	Natural variant	ID=VAR_013758;Note=In GBBB1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9718340;Dbxref=PMID:9718340
MID1	O15344	428	482	438	438	Natural variant	ID=VAR_013759;Note=In GBBB1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9354791;Dbxref=PMID:9354791
MID1	O15344	428	482	438	438	Natural variant	ID=VAR_013759;Note=In GBBB1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9354791;Dbxref=PMID:9354791
MID1	O15344	428	482	438	438	Natural variant	ID=VAR_013759;Note=In GBBB1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9354791;Dbxref=PMID:9354791
MID1	O15344	428	482	438	438	Natural variant	ID=VAR_013759;Note=In GBBB1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9354791;Dbxref=PMID:9354791
MID1	O15344	428	482	438	438	Natural variant	ID=VAR_013759;Note=In GBBB1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9354791;Dbxref=PMID:9354791
MID1	O15344	428	482	438	438	Natural variant	ID=VAR_013759;Note=In GBBB1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9354791;Dbxref=PMID:9354791
MID1	O15344	220	252	228	228	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MID1	O15344	220	252	228	228	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MID1	O15344	220	252	228	228	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MID1	O15344	220	252	228	228	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MID1	O15344	220	252	228	228	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MID1	O15344	220	252	228	228	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIM29	Q14134	509	542	1	588	Chain	ID=PRO_0000056242;Note=Tripartite motif-containing protein 29
TRIM29	Q14134	509	542	514	514	Natural variant	ID=VAR_035962;Note=In a breast cancer sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs112973609,PMID:16959974
TRIM33	Q9UPN9	1040	1057	1	1127	Chain	ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33
TRIM33	Q9UPN9	964	989	1	1127	Chain	ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33
TRIM33	Q9UPN9	620	687	1	1127	Chain	ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33
TRIM33	Q9UPN9	565	620	1	1127	Chain	ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33
TRIM33	Q9UPN9	1040	1057	974	1046	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
TRIM33	Q9UPN9	964	989	974	1046	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
TRIM33	Q9UPN9	964	989	964	965	Site	Note=Breakpoint for translocation to form TRIM33-RET oncogene
TRIM33	Q9UPN9	565	620	577	577	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TRIM33	Q9UPN9	565	620	591	591	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99PP7
TRIM33	Q9UPN9	565	620	591	591	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TRIM33	Q9UPN9	565	620	598	598	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TRIM33	Q9UPN9	565	620	604	604	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TRIM33	Q9UPN9	1040	1057	1051	1051	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRIM33	Q9UPN9	1040	1057	1043	1043	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TRIM33	Q9UPN9	1040	1057	1057	1057	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
TRIM33	Q9UPN9	1040	1057	1041	1057	Alternative sequence	ID=VSP_005774;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10439047,ECO:0000303|PubMed:11331580;Dbxref=PMID:10439047,PMID:11331580
TRIM33	Q9UPN9	565	620	580	580	Natural variant	ID=VAR_042376;Note=In a glioblastoma multiforme sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
TRIM33	Q9UPN9	964	989	960	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR8
TRIM33	Q9UPN9	964	989	980	982	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR8
TUBA3D	P0DPH8	125	352	1	450	Chain	ID=PRO_0000444671;Note=Tubulin alpha-3D chain
TUBA3D	P0DPH8	125	352	1	449	Chain	ID=PRO_0000444672;Note=Detyrosinated tubulin alpha-3D chain;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:25908662,ECO:0000305|PubMed:29146869;Dbxref=PMID:25908662,PMID:29146869
TUBA3D	P0DPH8	125	352	142	148	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUBA3D	P0DPH8	125	352	282	282	Modified residue	Note=Nitrated tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68373
TUBA3D	P0DPH8	125	352	11	450	Natural variant	ID=VAR_080471;Note=In KTCN9%3B loss of protein. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29051577;Dbxref=PMID:29051577
TUBA3D	P0DPH8	125	352	305	305	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
TUBB4B	P68371	55	92	1	445	Chain	ID=PRO_0000048248;Note=Tubulin beta-4B chain
TUBB4B	P68371	55	92	55	55	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TUBB4B	P68371	55	92	58	58	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TUBB6	Q9BUF5	55	92	1	446	Chain	ID=PRO_0000048255;Note=Tubulin beta-6 chain
TUBB6	Q9BUF5	55	92	91	91	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RSPO2	Q6UXX9	31	94	22	243	Chain	ID=PRO_0000234439;Note=R-spondin-2
RSPO2	Q6UXX9	31	94	90	134	Repeat	Note=FU
RSPO2	Q6UXX9	31	94	40	46	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO2	Q6UXX9	31	94	43	52	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO2	Q6UXX9	31	94	55	74	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO2	Q6UXX9	31	94	78	93	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO2	Q6UXX9	31	94	1	67	Alternative sequence	ID=VSP_018321;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RSPO2	Q6UXX9	31	94	32	95	Alternative sequence	ID=VSP_018322;Note=In isoform 3. ASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCAR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCEA1	P23193	275	299	1	301	Chain	ID=PRO_0000121446;Note=Transcription elongation factor A protein 1
TCEA1	P23193	226	275	1	301	Chain	ID=PRO_0000121446;Note=Transcription elongation factor A protein 1
TCEA1	P23193	21	42	1	301	Chain	ID=PRO_0000121446;Note=Transcription elongation factor A protein 1
TCEA1	P23193	21	42	3	80	Domain	Note=TFIIS N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00649
TCEA1	P23193	226	275	140	256	Domain	Note=TFIIS central;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00651
TCEA1	P23193	275	299	259	299	Zinc finger	Note=TFIIS-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00472
TCEA1	P23193	226	275	259	299	Zinc finger	Note=TFIIS-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00472
TCEA1	P23193	21	42	22	42	Alternative sequence	ID=VSP_006409;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1708494;Dbxref=PMID:1708494
TCEA1	P23193	226	275	237	237	Sequence conflict	Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCEA1	P23193	275	299	285	285	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCEA1	P23193	226	275	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NDQ
TCEA1	P23193	226	275	264	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TFI
TCEA1	P23193	275	299	271	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TFI
TCEA1	P23193	226	275	271	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TFI
TCEA1	P23193	275	299	278	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TFI
TCEA1	P23193	275	299	286	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TFI
TCEA1	P23193	275	299	297	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TFI
TCF25	Q9BQ70	64	118	1	676	Chain	ID=PRO_0000087265;Note=Transcription factor 25
TCF25	Q9BQ70	183	204	1	676	Chain	ID=PRO_0000087265;Note=Transcription factor 25
TCF25	Q9BQ70	490	542	1	676	Chain	ID=PRO_0000087265;Note=Transcription factor 25
TCP1	P17987	50	93	1	556	Chain	ID=PRO_0000128302;Note=T-complex protein 1 subunit alpha
CCT3	P49368	467	511	1	545	Chain	ID=PRO_0000128321;Note=T-complex protein 1 subunit gamma
CCT3	P49368	385	467	1	545	Chain	ID=PRO_0000128321;Note=T-complex protein 1 subunit gamma
CCT3	P49368	203	253	1	545	Chain	ID=PRO_0000128321;Note=T-complex protein 1 subunit gamma
CCT3	P49368	48	69	1	545	Chain	ID=PRO_0000128321;Note=T-complex protein 1 subunit gamma
CCT3	P49368	31	48	1	545	Chain	ID=PRO_0000128321;Note=T-complex protein 1 subunit gamma
CCT3	P49368	203	253	222	222	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CCT3	P49368	203	253	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCT3	P49368	203	253	244	244	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
CCT3	P49368	203	253	247	247	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCT3	P49368	203	253	252	252	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:23186163,PMID:24275569
CCT3	P49368	385	467	430	430	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCT3	P49368	385	467	459	459	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCT3	P49368	203	253	248	248	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CCT3	P49368	203	253	249	249	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CCT3	P49368	48	69	32	69	Alternative sequence	ID=VSP_042026;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT3	P49368	31	48	32	69	Alternative sequence	ID=VSP_042026;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT3	P49368	385	467	391	391	Natural variant	ID=VAR_052265;Note=L->F;Dbxref=dbSNP:rs2230194
CCT3	P49368	203	253	251	251	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT8	P50990	483	523	2	548	Chain	ID=PRO_0000128373;Note=T-complex protein 1 subunit theta
CCT8	P50990	404	428	2	548	Chain	ID=PRO_0000128373;Note=T-complex protein 1 subunit theta
CCT8	P50990	208	254	2	548	Chain	ID=PRO_0000128373;Note=T-complex protein 1 subunit theta
CCT8	P50990	208	254	213	213	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCT8	P50990	483	523	505	505	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
CCT8	P50990	208	254	224	224	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CCT8	P50990	208	254	254	254	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CCT8	P50990	404	428	409	409	Natural variant	ID=VAR_052271;Note=V->I;Dbxref=dbSNP:rs8129954
TECPR2	O15040	116	160	1	1411	Chain	ID=PRO_0000050747;Note=Tectonin beta-propeller repeat-containing protein 2
TECPR2	O15040	361	472	1	1411	Chain	ID=PRO_0000050747;Note=Tectonin beta-propeller repeat-containing protein 2
TECPR2	O15040	1135	1213	1	1411	Chain	ID=PRO_0000050747;Note=Tectonin beta-propeller repeat-containing protein 2
TECPR2	O15040	1310	1360	1	1411	Chain	ID=PRO_0000050747;Note=Tectonin beta-propeller repeat-containing protein 2
TECPR2	O15040	116	160	115	161	Repeat	Note=WD 3
TECPR2	O15040	1135	1213	1179	1209	Repeat	Note=TECPR 3
TECPR2	O15040	1310	1360	1279	1310	Repeat	Note=TECPR 5
TECPR2	O15040	1310	1360	1322	1353	Repeat	Note=TECPR 6
TECPR2	O15040	361	472	462	471	Compositional bias	Note=Poly-Lys
TECPR2	O15040	1310	1360	1268	1411	Alternative sequence	ID=VSP_044794;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TECPR2	O15040	361	472	386	386	Natural variant	ID=VAR_046530;Note=A->T;Dbxref=dbSNP:rs11845676
TECPR2	O15040	361	472	439	439	Natural variant	ID=VAR_046531;Note=P->S;Dbxref=dbSNP:rs2273906
TDRD3	Q9H7E2	72	96	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	146	193	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	571	613	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	72	96	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	146	193	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	571	613	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	72	96	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	146	193	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	571	613	1	651	Chain	ID=PRO_0000183163;Note=Tudor domain-containing protein 3
TDRD3	Q9H7E2	146	193	193	233	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TDRD3	Q9H7E2	146	193	193	233	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TDRD3	Q9H7E2	146	193	193	233	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TDRD3	Q9H7E2	571	613	555	615	Domain	Note=Tudor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00211
TDRD3	Q9H7E2	571	613	555	615	Domain	Note=Tudor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00211
TDRD3	Q9H7E2	571	613	555	615	Domain	Note=Tudor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00211
TDRD3	Q9H7E2	571	613	598	598	Mutagenesis	Note=Abolishes interaction with dimethylarginine-containing protein motifs and reduces association with mRNA stress granules. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18632687;Dbxref=PMID:18632687
TDRD3	Q9H7E2	571	613	598	598	Mutagenesis	Note=Abolishes interaction with dimethylarginine-containing protein motifs and reduces association with mRNA stress granules. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18632687;Dbxref=PMID:18632687
TDRD3	Q9H7E2	571	613	598	598	Mutagenesis	Note=Abolishes interaction with dimethylarginine-containing protein motifs and reduces association with mRNA stress granules. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18632687;Dbxref=PMID:18632687
TDRD3	Q9H7E2	571	613	572	581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	572	581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	572	581	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	582	585	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	582	585	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	582	585	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	586	591	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	586	591	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	586	591	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	592	594	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	592	594	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	592	594	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	597	601	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	597	601	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	597	601	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	602	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	602	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	602	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	605	607	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	605	607	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD3	Q9H7E2	571	613	605	607	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YJ8
TDRD6	O60522	2057	2087	1	2096	Chain	ID=PRO_0000183167;Note=Tudor domain-containing protein 6
TDRD6	O60522	2057	2087	2026	2084	Domain	Note=Tudor 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00211
TDRD6	O60522	2057	2087	2062	2062	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61407
TDRD6	O60522	2057	2087	2058	2087	Alternative sequence	ID=VSP_044801;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNTT	P04053	126	169	1	509	Chain	ID=PRO_0000218791;Note=DNA nucleotidylexotransferase
DNTT	P04053	126	169	151	509	Region	Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12786946;Dbxref=PMID:12786946
DNTT	P04053	126	169	134	134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09838
RXFP1	Q9HBX9	62	95	1	757	Chain	ID=PRO_0000069700;Note=Relaxin receptor 1
RXFP1	Q9HBX9	131	154	1	757	Chain	ID=PRO_0000069700;Note=Relaxin receptor 1
RXFP1	Q9HBX9	203	226	1	757	Chain	ID=PRO_0000069700;Note=Relaxin receptor 1
RXFP1	Q9HBX9	252	275	1	757	Chain	ID=PRO_0000069700;Note=Relaxin receptor 1
RXFP1	Q9HBX9	585	658	1	757	Chain	ID=PRO_0000069700;Note=Relaxin receptor 1
RXFP1	Q9HBX9	62	95	1	409	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	131	154	1	409	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	203	226	1	409	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	252	275	1	409	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	585	658	578	598	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	585	658	599	629	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	585	658	630	650	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	585	658	651	651	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	585	658	652	672	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
RXFP1	Q9HBX9	62	95	26	63	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
RXFP1	Q9HBX9	62	95	91	127	Domain	Note=LRRNT
RXFP1	Q9HBX9	131	154	151	172	Repeat	Note=LRR 1
RXFP1	Q9HBX9	203	226	199	220	Repeat	Note=LRR 3
RXFP1	Q9HBX9	203	226	223	244	Repeat	Note=LRR 4
RXFP1	Q9HBX9	252	275	248	269	Repeat	Note=LRR 5
RXFP1	Q9HBX9	252	275	272	293	Repeat	Note=LRR 6
RXFP1	Q9HBX9	252	275	264	264	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18533687;Dbxref=PMID:18533687
RXFP1	Q9HBX9	252	275	272	272	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18533687;Dbxref=PMID:18533687
RXFP1	Q9HBX9	62	95	47	62	Disulfide bond	.
RXFP1	Q9HBX9	62	95	1	81	Alternative sequence	ID=VSP_054375;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RXFP1	Q9HBX9	62	95	63	96	Alternative sequence	ID=VSP_001984;Note=In isoform 2. GDNNGWSLQFDKYFASYYKMTSQYPFEAETPECL->V;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10935549,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16051677;Dbxref=PMID:10935549,PMID:14702039,PMID:16051677
RXFP1	Q9HBX9	203	226	190	757	Alternative sequence	ID=VSP_029878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16051677;Dbxref=PMID:16051677
RXFP1	Q9HBX9	252	275	190	757	Alternative sequence	ID=VSP_029878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16051677;Dbxref=PMID:16051677
RXFP1	Q9HBX9	585	658	190	757	Alternative sequence	ID=VSP_029878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16051677;Dbxref=PMID:16051677
RXFP1	Q9HBX9	252	275	252	275	Alternative sequence	ID=VSP_054376;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RXFP1	Q9HBX9	585	658	637	637	Mutagenesis	Note=Leads to constitutive increase of basal cAMP. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10935549;Dbxref=PMID:10935549
RXFP1	Q9HBX9	62	95	70	70	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
S100A14	Q9HCY8	10	59	1	104	Chain	ID=PRO_0000144021;Note=Protein S100-A14
S100A14	Q9HCY8	10	59	1	104	Chain	ID=PRO_0000144021;Note=Protein S100-A14
S100A14	Q9HCY8	10	59	1	104	Chain	ID=PRO_0000144021;Note=Protein S100-A14
S100A14	Q9HCY8	10	59	27	61	Domain	Note=EF-hand
S100A14	Q9HCY8	10	59	27	61	Domain	Note=EF-hand
S100A14	Q9HCY8	10	59	27	61	Domain	Note=EF-hand
S100A14	Q9HCY8	10	59	8	11	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	8	11	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	8	11	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	19	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	19	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	19	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	34	39	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	34	39	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	34	39	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	43	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	43	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	43	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	55	57	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	55	57	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
S100A14	Q9HCY8	10	59	55	57	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2M0R
SEC14L1	Q92503	115	158	1	715	Chain	ID=PRO_0000210753;Note=SEC14-like protein 1
SEC14L1	Q92503	115	158	1	715	Chain	ID=PRO_0000210753;Note=SEC14-like protein 1
SEC14L1	Q92503	115	158	1	715	Chain	ID=PRO_0000210753;Note=SEC14-like protein 1
SEC14L1	Q92503	115	158	1	175	Domain	Note=PRELI/MSF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00158
SEC14L1	Q92503	115	158	1	175	Domain	Note=PRELI/MSF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00158
SEC14L1	Q92503	115	158	1	175	Domain	Note=PRELI/MSF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00158
SEC14L1	Q92503	115	158	1	510	Region	Note=Required for interaction and inhibitory function toward DDX58;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23843640;Dbxref=PMID:23843640
SEC14L1	Q92503	115	158	1	510	Region	Note=Required for interaction and inhibitory function toward DDX58;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23843640;Dbxref=PMID:23843640
SEC14L1	Q92503	115	158	1	510	Region	Note=Required for interaction and inhibitory function toward DDX58;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23843640;Dbxref=PMID:23843640
SEC14L1	Q92503	115	158	127	127	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC14L1	Q92503	115	158	127	127	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC14L1	Q92503	115	158	127	127	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC12A2	P55011	591	627	1	1212	Chain	ID=PRO_0000178023;Note=Solute carrier family 12 member 2
SLC12A2	P55011	934	976	1	1212	Chain	ID=PRO_0000178023;Note=Solute carrier family 12 member 2
SLC12A2	P55011	976	992	1	1212	Chain	ID=PRO_0000178023;Note=Solute carrier family 12 member 2
SLC12A2	P55011	591	627	542	591	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A2	P55011	591	627	592	612	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A2	P55011	591	627	613	654	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A2	P55011	934	976	921	1212	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A2	P55011	976	992	921	1212	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A2	P55011	934	976	940	940	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLC12A2	P55011	934	976	944	944	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P55012
SLC12A2	P55011	934	976	976	991	Alternative sequence	ID=VSP_006105;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11700976;Dbxref=PMID:11700976
SLC12A2	P55011	976	992	976	991	Alternative sequence	ID=VSP_006105;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11700976;Dbxref=PMID:11700976
SLC20A2	Q08357	243	311	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	204	243	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	96	143	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	243	311	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	204	243	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	96	143	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	243	311	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	204	243	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	96	143	1	652	Chain	ID=PRO_0000341268;Note=Sodium-dependent phosphate transporter 2
SLC20A2	Q08357	96	143	87	107	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	87	107	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	87	107	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	108	109	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	108	109	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	108	109	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	131	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	131	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	131	142	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	96	143	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	191	211	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	191	211	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	191	211	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	212	213	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	212	213	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	212	213	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	243	311	235	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	235	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	243	311	235	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	235	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	243	311	235	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	204	243	235	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A2	Q08357	243	311	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63488
SLC20A2	Q08357	243	311	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63488
SLC20A2	Q08357	243	311	253	253	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63488
SLC20A2	Q08357	243	311	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLC20A2	Q08357	243	311	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLC20A2	Q08357	243	311	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLC20A2	Q08357	243	311	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SLC20A2	Q08357	243	311	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SLC20A2	Q08357	243	311	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SLC20A2	Q08357	243	311	268	268	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SLC20A2	Q08357	243	311	268	268	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SLC20A2	Q08357	243	311	268	268	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SLC20A2	Q08357	96	143	115	115	Natural variant	ID=VAR_072260;Note=In IBGC1. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24463626;Dbxref=dbSNP:rs775911275,PMID:24463626
SLC20A2	Q08357	96	143	115	115	Natural variant	ID=VAR_072260;Note=In IBGC1. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24463626;Dbxref=dbSNP:rs775911275,PMID:24463626
SLC20A2	Q08357	96	143	115	115	Natural variant	ID=VAR_072260;Note=In IBGC1. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24463626;Dbxref=dbSNP:rs775911275,PMID:24463626
SLC15A2	Q16348	112	142	1	729	Chain	ID=PRO_0000064308;Note=Solute carrier family 15 member 2
SLC15A2	Q16348	260	289	1	729	Chain	ID=PRO_0000064308;Note=Solute carrier family 15 member 2
SLC15A2	Q16348	636	671	1	729	Chain	ID=PRO_0000064308;Note=Solute carrier family 15 member 2
SLC15A2	Q16348	112	142	105	113	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC15A2	Q16348	112	142	114	134	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A2	Q16348	112	142	135	139	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC15A2	Q16348	112	142	140	160	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A2	Q16348	260	289	239	295	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC15A2	Q16348	636	671	633	643	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC15A2	Q16348	636	671	644	664	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A2	Q16348	636	671	665	674	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC15A2	Q16348	112	142	113	143	Alternative sequence	ID=VSP_043084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC15A2	Q16348	260	289	278	279	Sequence conflict	Note=QH->HD;Ontology_term=ECO:0000305;evidence=ECO:0000305
TESK1	Q15569	130	179	1	626	Chain	ID=PRO_0000086746;Note=Dual specificity testis-specific protein kinase 1
TESK1	Q15569	237	265	1	626	Chain	ID=PRO_0000086746;Note=Dual specificity testis-specific protein kinase 1
TESK1	Q15569	130	179	57	314	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TESK1	Q15569	237	265	57	314	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TESK1	Q15569	130	179	175	175	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
SLC22A10	Q63ZE4	465	532	1	541	Chain	ID=PRO_0000233716;Note=Solute carrier family 22 member 10
SLC22A10	Q63ZE4	465	532	458	472	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A10	Q63ZE4	465	532	473	493	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A10	Q63ZE4	465	532	494	495	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A10	Q63ZE4	465	532	496	516	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A10	Q63ZE4	465	532	517	541	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A10	Q63ZE4	465	532	425	541	Alternative sequence	ID=VSP_056647;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15221005;Dbxref=PMID:15221005
SLC23A3	Q6PIS1	424	480	1	610	Chain	ID=PRO_0000337203;Note=Solute carrier family 23 member 3
SLC23A3	Q6PIS1	424	480	424	446	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A3	Q6PIS1	424	480	447	452	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A3	Q6PIS1	424	480	453	472	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC23A3	Q6PIS1	424	480	473	486	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23IP	Q9Y6Y8	367	397	1	1000	Chain	ID=PRO_0000097554;Note=SEC23-interacting protein
SEC23IP	Q9Y6Y8	437	467	1	1000	Chain	ID=PRO_0000097554;Note=SEC23-interacting protein
SEC23IP	Q9Y6Y8	624	675	1	1000	Chain	ID=PRO_0000097554;Note=SEC23-interacting protein
SEC23IP	Q9Y6Y8	771	823	1	1000	Chain	ID=PRO_0000097554;Note=SEC23-interacting protein
SEC23IP	Q9Y6Y8	624	675	644	707	Domain	Note=SAM
SEC23IP	Q9Y6Y8	771	823	779	989	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
SEC23IP	Q9Y6Y8	367	397	1	367	Region	Note=Interaction with SEC23A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10400679;Dbxref=PMID:10400679
SEC23IP	Q9Y6Y8	624	675	644	644	Natural variant	ID=VAR_019806;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|Ref.2,ECO:0000269|Ref.3;Dbxref=dbSNP:rs2475298
SLC25A34	Q6PIV7	148	199	1	304	Chain	ID=PRO_0000291789;Note=Solute carrier family 25 member 34
SLC25A34	Q6PIV7	199	244	1	304	Chain	ID=PRO_0000291789;Note=Solute carrier family 25 member 34
SLC25A34	Q6PIV7	148	199	170	191	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A34	Q6PIV7	199	244	206	226	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A34	Q6PIV7	148	199	101	194	Repeat	Note=Solcar 2
SLC25A34	Q6PIV7	199	244	204	295	Repeat	Note=Solcar 3
SLC25A34	Q6PIV7	148	199	198	198	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC25A40	Q8TBP6	274	301	1	338	Chain	ID=PRO_0000291809;Note=Solute carrier family 25 member 40
SLC25A40	Q8TBP6	274	301	298	318	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A40	Q8TBP6	274	301	233	327	Repeat	Note=Solcar 3
SLC25A38	Q96DW6	92	152	1	304	Chain	ID=PRO_0000291802;Note=Mitochondrial glycine transporter
SLC25A38	Q96DW6	92	152	89	115	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03064
SLC25A38	Q96DW6	92	152	127	152	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03064
SLC25A38	Q96DW6	92	152	25	114	Repeat	Note=Solcar 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03064
SLC25A38	Q96DW6	92	152	121	205	Repeat	Note=Solcar 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03064
SLC25A38	Q96DW6	92	152	130	130	Natural variant	ID=VAR_058093;Note=In SIDBA2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19412178;Dbxref=dbSNP:rs762562272,PMID:19412178
SLC25A38	Q96DW6	92	152	134	134	Natural variant	ID=VAR_058094;Note=In SIDBA2. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19412178;Dbxref=PMID:19412178
SLC25A47	Q6Q0C1	48	109	1	308	Chain	ID=PRO_0000291779;Note=Solute carrier family 25 member 47
SLC25A47	Q6Q0C1	48	109	49	69	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A47	Q6Q0C1	48	109	98	116	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A47	Q6Q0C1	48	109	1	80	Repeat	Note=Solcar 1
SLC25A47	Q6Q0C1	48	109	93	206	Repeat	Note=Solcar 2
SLC25A47	Q6Q0C1	48	109	31	308	Alternative sequence	ID=VSP_026234;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15221005,ECO:0000303|PubMed:15322095;Dbxref=PMID:15221005,PMID:15322095
SAP30BP	Q9UHR5	72	88	1	308	Chain	ID=PRO_0000245791;Note=SAP30-binding protein
SAP30BP	Q9UHR5	72	88	73	88	Alternative sequence	ID=VSP_052091;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A4	O43511	101	138	1	780	Chain	ID=PRO_0000080164;Note=Pendrin
SLC26A4	O43511	200	255	1	780	Chain	ID=PRO_0000080164;Note=Pendrin
SLC26A4	O43511	255	306	1	780	Chain	ID=PRO_0000080164;Note=Pendrin
SLC26A4	O43511	421	447	1	780	Chain	ID=PRO_0000080164;Note=Pendrin
SLC26A4	O43511	569	601	1	780	Chain	ID=PRO_0000080164;Note=Pendrin
SLC26A4	O43511	101	138	88	108	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	101	138	109	109	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	101	138	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	101	138	131	135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	101	138	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	200	255	192	212	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	200	255	213	218	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	200	255	219	239	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	200	255	240	263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	255	306	240	263	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	255	306	264	284	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	255	306	285	295	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	255	306	296	316	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	421	447	406	421	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	421	447	422	442	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	421	447	443	448	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	569	601	508	780	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A4	O43511	569	601	535	729	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A4	O43511	101	138	1	431	Alternative sequence	ID=VSP_056688;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A4	O43511	200	255	1	431	Alternative sequence	ID=VSP_056688;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A4	O43511	255	306	1	431	Alternative sequence	ID=VSP_056688;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A4	O43511	421	447	1	431	Alternative sequence	ID=VSP_056688;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A4	O43511	101	138	102	102	Natural variant	ID=VAR_021643;Note=In PDS%3B fails to localize to cell membrane%3B abolishes iodide transport. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11932316;Dbxref=PMID:11932316
SLC26A4	O43511	101	138	104	104	Natural variant	ID=VAR_021644;Note=In Pendred syndrome/deafness individuals. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14679580;Dbxref=PMID:14679580
SLC26A4	O43511	101	138	105	105	Natural variant	ID=VAR_021645;Note=In PDS. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11317356,ECO:0000269|PubMed:14679580;Dbxref=dbSNP:rs1442599990,PMID:11317356,PMID:14679580
SLC26A4	O43511	101	138	106	106	Natural variant	ID=VAR_021646;Note=In PDS. A->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11317356,ECO:0000269|PubMed:14679580;Dbxref=PMID:11317356,PMID:14679580
SLC26A4	O43511	101	138	117	117	Natural variant	ID=VAR_021647;Note=In DFNB4 and PDS%3B does not affect protein localization to cell membrane%3B does not affect iodide transport. L->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10700480,ECO:0000269|PubMed:11932316;Dbxref=dbSNP:rs145254330,PMID:10700480,PMID:11932316
SLC26A4	O43511	101	138	123	123	Natural variant	ID=VAR_027238;Note=In DFNB4. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14508505;Dbxref=dbSNP:rs984967571,PMID:14508505
SLC26A4	O43511	101	138	132	132	Natural variant	ID=VAR_021648;Note=In DFNB4. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11748854;Dbxref=PMID:11748854
SLC26A4	O43511	101	138	133	133	Natural variant	ID=VAR_021649;Note=In PDS. S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11919333,ECO:0000269|PubMed:12788906;Dbxref=dbSNP:rs121908365,PMID:11919333,PMID:12788906
SLC26A4	O43511	101	138	137	137	Natural variant	ID=VAR_021650;Note=In PDS. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15355436;Dbxref=PMID:15355436
SLC26A4	O43511	101	138	138	138	Natural variant	ID=VAR_021651;Note=In PDS%3B fails to localize to cell membrane%3B abolishes iodide transport. V->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11317356,ECO:0000269|PubMed:11375792,ECO:0000269|PubMed:11932316,ECO:0000269|PubMed:12788906,ECO:0000269|PubMed:14679580,ECO:0000269|PubMed:15355436,ECO:0000269|PubMed:19204907,ECO:0000269|PubMed:9618166,ECO:0000269|PubMed:9618167;Dbxref=dbSNP:rs111033199,PMID:11317356,PMID:11375792,PMID:11932316,PMID:12788906,PMID:14679580,PMID:15355436,PMID:19204907,PMID:9618166,PMID:9618167
SLC26A4	O43511	200	255	209	209	Natural variant	ID=VAR_007440;Note=In DFNB4 and PDS%3B severely reduces iodide transport without affecting protein localization to cell membrane. G->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10190331,ECO:0000269|PubMed:10700480,ECO:0000269|PubMed:11317356,ECO:0000269|PubMed:11932316,ECO:0000269|PubMed:14679580,ECO:0000269|PubMed:15355436,ECO:0000269|PubMed:19204907,ECO:0000269|PubMed:9618166;Dbxref=dbSNP:rs111033303,PMID:10190331,PMID:10700480,PMID:11317356,PMID:11932316,PMID:14679580,PMID:15355436,PMID:19204907,PMID:9618166
SLC26A4	O43511	200	255	227	227	Natural variant	ID=VAR_079503;Note=In DFNB4. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28281779;Dbxref=PMID:28281779
SLC26A4	O43511	200	255	236	236	Natural variant	ID=VAR_007441;Note=In PDS and DFNB4%3B common mutation%3B fails to localize to cell membrane%3B abolishes iodide transport. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10700480,ECO:0000269|PubMed:11317356,ECO:0000269|PubMed:11932316,ECO:0000269|PubMed:14679580,ECO:0000269|PubMed:15355436,ECO:0000269|PubMed:19204907,ECO:0000269|PubMed:9618166,ECO:0000269|PubMed:9618167;Dbxref=dbSNP:rs80338848,PMID:10700480,PMID:11317356,PMID:11932316,PMID:14679580,PMID:15355436,PMID:19204907,PMID:9618166,PMID:9618167
SLC26A4	O43511	200	255	239	239	Natural variant	ID=VAR_021653;Note=In PDS and DFNB4. V->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676893,ECO:0000269|PubMed:12974744;Dbxref=dbSNP:rs111033256,PMID:12676893,PMID:12974744
SLC26A4	O43511	200	255	252	252	Natural variant	ID=VAR_021654;Note=In DFNB4. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12676893;Dbxref=dbSNP:rs1315422549,PMID:12676893
SLC26A4	O43511	255	306	271	271	Natural variant	ID=VAR_021655;Note=In PDS. D->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14679580,ECO:0000269|PubMed:9618166;Dbxref=PMID:14679580,PMID:9618166
SLC26A4	O43511	255	306	281	281	Natural variant	ID=VAR_064992;Note=In DFNB4. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20597900;Dbxref=dbSNP:rs727505080,PMID:20597900
SLC26A4	O43511	255	306	301	301	Natural variant	ID=VAR_053663;Note=P->L;Dbxref=dbSNP:rs34373141
SLC26A4	O43511	421	447	421	421	Natural variant	ID=VAR_021663;Note=In Pendred syndrome/deafness individuals. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14679580;Dbxref=dbSNP:rs201660407,PMID:14679580
SLC26A4	O43511	421	447	429	429	Natural variant	ID=VAR_021664;Note=In Pendred syndrome/deafness individuals. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14679580;Dbxref=PMID:14679580
SLC26A4	O43511	421	447	445	445	Natural variant	ID=VAR_011624;Note=In PDS and DFNB4%3B also found at heterozygosity in a patient with hearing loss and unilateral enlargement of the vestibular aqueduct%3B uncertain pathological significance. L->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10602116,ECO:0000269|PubMed:10700480,ECO:0000269|PubMed:11748854,ECO:0000269|PubMed:14679580,ECO:0000269|PubMed:15355436,ECO:0000269|PubMed:19204907,ECO:0000269|PubMed:24051746,ECO:0000269|PubMed:9618166;Dbxref=dbSNP:rs111033307,PMID:10602116,PMID:10700480,PMID:11748854,PMID:14679580,PMID:15355436,PMID:19204907,PMID:24051746,PMID:9618166
SLC26A4	O43511	421	447	446	446	Natural variant	ID=VAR_021665;Note=In DFNB4 and PDS%3B fails to localize to cell membrane%3B abolishes iodide transport. Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10700480,ECO:0000269|PubMed:11932316;Dbxref=dbSNP:rs768471577,PMID:10700480,PMID:11932316
SLC26A4	O43511	569	601	597	597	Natural variant	ID=VAR_021675;Note=Found at heterozygosity in a patient with hearing loss and unilateral enlargement of the vestibular aqueduct%3B uncertain pathological significance. L->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11317356,ECO:0000269|PubMed:11919333,ECO:0000269|PubMed:14679580,ECO:0000269|PubMed:15355436,ECO:0000269|PubMed:19204907,ECO:0000269|PubMed:20597900,ECO:0000269|PubMed:24051746;Dbxref=dbSNP:rs55638457,PMID:11317356,PMID:11919333,PMID:14679580,PMID:15355436,PMID:19204907,PMID:20597900,PMID:24051746
SLC26A9	Q7LBE3	553	591	1	791	Chain	ID=PRO_0000324492;Note=Solute carrier family 26 member 9
SLC26A9	Q7LBE3	405	431	1	791	Chain	ID=PRO_0000324492;Note=Solute carrier family 26 member 9
SLC26A9	Q7LBE3	239	290	1	791	Chain	ID=PRO_0000324492;Note=Solute carrier family 26 member 9
SLC26A9	Q7LBE3	184	239	1	791	Chain	ID=PRO_0000324492;Note=Solute carrier family 26 member 9
SLC26A9	Q7LBE3	88	125	1	791	Chain	ID=PRO_0000324492;Note=Solute carrier family 26 member 9
SLC26A9	Q7LBE3	88	125	71	91	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	88	125	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	88	125	115	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	184	239	179	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	184	239	200	220	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	239	290	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	184	239	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	239	290	249	269	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	239	290	280	300	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	405	431	406	426	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A9	Q7LBE3	553	591	519	737	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A9	Q7LBE3	239	290	290	293	Compositional bias	Note=Poly-Val
SLC26A9	Q7LBE3	553	591	575	575	Natural variant	ID=VAR_068686;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22544634;Dbxref=dbSNP:rs201823199,PMID:22544634
SAAL1	Q96ER3	284	347	1	474	Chain	ID=PRO_0000279540;Note=Protein SAAL1
SAAL1	Q96ER3	83	111	1	474	Chain	ID=PRO_0000279540;Note=Protein SAAL1
SAAL1	Q96ER3	45	83	1	474	Chain	ID=PRO_0000279540;Note=Protein SAAL1
SAAL1	Q96ER3	284	347	315	315	Natural variant	ID=VAR_053846;Note=I->V;Dbxref=dbSNP:rs35525096
SLC39A9	Q9NUM3	68	134	1	307	Chain	ID=PRO_0000297597;Note=Zinc transporter ZIP9
SLC39A9	Q9NUM3	134	157	1	307	Chain	ID=PRO_0000297597;Note=Zinc transporter ZIP9
SLC39A9	Q9NUM3	68	134	106	126	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A9	Q9NUM3	134	157	146	166	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A9	Q9NUM3	134	157	135	157	Alternative sequence	ID=VSP_027302;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SLC39A9	Q9NUM3	68	134	122	122	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RSU1	Q15404	36	53	2	277	Chain	ID=PRO_0000097499;Note=Ras suppressor protein 1
RSU1	Q15404	36	53	41	63	Repeat	Note=LRR 1
RSU1	Q15404	36	53	1	53	Alternative sequence	ID=VSP_043831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBL2	Q9Y4P3	242	292	1	447	Chain	ID=PRO_0000051270;Note=Transducin beta-like protein 2
TBL2	Q9Y4P3	242	292	228	267	Repeat	Note=WD 4
TBL2	Q9Y4P3	242	292	277	316	Repeat	Note=WD 5
RSRC2	Q7L4I2	345	375	2	434	Chain	ID=PRO_0000314937;Note=Arginine/serine-rich coiled-coil protein 2
RSRC2	Q7L4I2	201	241	2	434	Chain	ID=PRO_0000314937;Note=Arginine/serine-rich coiled-coil protein 2
RSRC2	Q7L4I2	201	241	230	270	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RSRC2	Q7L4I2	345	375	375	375	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
RSRC2	Q7L4I2	345	375	375	375	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RSRC2	Q7L4I2	201	241	224	224	Sequence conflict	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPS14	O60783	15	68	1	128	Chain	ID=PRO_0000131013;Note=28S ribosomal protein S14%2C mitochondrial
RTN2	O75298	271	344	1	545	Chain	ID=PRO_0000030351;Note=Reticulon-2
RTN2	O75298	271	344	1	340	Alternative sequence	ID=VSP_018870;Note=In isoform RTN2-C. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RTN2	O75298	271	344	272	344	Alternative sequence	ID=VSP_005649;Note=In isoform RTN2-B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9530622;Dbxref=PMID:9530622
RUFY3	Q7L099	298	329	1	469	Chain	ID=PRO_0000245833;Note=Protein RUFY3
RUFY3	Q7L099	329	357	1	469	Chain	ID=PRO_0000245833;Note=Protein RUFY3
RUFY3	Q7L099	298	329	267	464	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RUFY3	Q7L099	329	357	267	464	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RUFY3	Q7L099	329	357	357	357	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RUSC2	Q8N2Y8	885	947	1	1516	Chain	ID=PRO_0000097534;Note=Iporin
RUSC2	Q8N2Y8	885	947	866	1516	Natural variant	ID=VAR_080461;Note=In MRT61%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27612186;Dbxref=PMID:27612186
TBX3	O15119	219	239	1	743	Chain	ID=PRO_0000184428;Note=T-box transcription factor TBX3
TBX3	O15119	219	239	107	220	DNA binding	Note=T-box%3B first part;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00201
TBX3	O15119	219	239	221	240	Alternative sequence	ID=VSP_006384;Note=In isoform I. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10468588,ECO:0000303|PubMed:9207801;Dbxref=PMID:10468588,PMID:9207801
TCHP	Q9BT92	152	175	1	498	Chain	ID=PRO_0000292609;Note=Trichoplein keratin filament-binding protein
TCHP	Q9BT92	440	488	1	498	Chain	ID=PRO_0000292609;Note=Trichoplein keratin filament-binding protein
TCHP	Q9BT92	152	175	1	498	Chain	ID=PRO_0000292609;Note=Trichoplein keratin filament-binding protein
TCHP	Q9BT92	440	488	1	498	Chain	ID=PRO_0000292609;Note=Trichoplein keratin filament-binding protein
TCHP	Q9BT92	152	175	73	498	Region	Note=Interaction with keratin proteins;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731013;Dbxref=PMID:15731013
TCHP	Q9BT92	440	488	73	498	Region	Note=Interaction with keratin proteins;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731013;Dbxref=PMID:15731013
TCHP	Q9BT92	152	175	73	498	Region	Note=Interaction with keratin proteins;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731013;Dbxref=PMID:15731013
TCHP	Q9BT92	440	488	73	498	Region	Note=Interaction with keratin proteins;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731013;Dbxref=PMID:15731013
TCHP	Q9BT92	152	175	163	353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	152	175	163	353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	440	488	380	479	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	440	488	380	479	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	152	175	70	482	Compositional bias	Note=Glu-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	440	488	70	482	Compositional bias	Note=Glu-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	152	175	70	482	Compositional bias	Note=Glu-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
TCHP	Q9BT92	440	488	70	482	Compositional bias	Note=Glu-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
RUVBL2	Q9Y230	334	373	2	463	Chain	ID=PRO_0000165644;Note=RuvB-like 2
RUVBL2	Q9Y230	334	373	331	334	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6H7X
RUVBL2	Q9Y230	334	373	341	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6H7X
RUVBL2	Q9Y230	334	373	348	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6H7X
RUVBL2	Q9Y230	334	373	354	359	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6H7X
RUVBL2	Q9Y230	334	373	364	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6H7X
TDRD12	Q587J7	107	146	1	1177	Chain	ID=PRO_0000311968;Note=Putative ATP-dependent RNA helicase TDRD12
TDRD12	Q587J7	347	373	1	1177	Chain	ID=PRO_0000311968;Note=Putative ATP-dependent RNA helicase TDRD12
TDRD12	Q587J7	107	146	56	118	Domain	Note=Tudor 1
TDRD12	Q587J7	107	146	107	107	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TDRD5	Q8NAT2	305	324	1	981	Chain	ID=PRO_0000183166;Note=Tudor domain-containing protein 5
TDRD5	Q8NAT2	507	577	1	981	Chain	ID=PRO_0000183166;Note=Tudor domain-containing protein 5
TDRD5	Q8NAT2	600	667	1	981	Chain	ID=PRO_0000183166;Note=Tudor domain-containing protein 5
TDRD5	Q8NAT2	720	774	1	981	Chain	ID=PRO_0000183166;Note=Tudor domain-containing protein 5
TDRD5	Q8NAT2	835	883	1	981	Chain	ID=PRO_0000183166;Note=Tudor domain-containing protein 5
TDRD5	Q8NAT2	305	324	295	369	Domain	Note=HTH OST-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00975
TDRD5	Q8NAT2	507	577	525	584	Domain	Note=Tudor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00211
TDRD5	Q8NAT2	720	774	720	720	Alternative sequence	ID=VSP_023968;Note=In isoform 1. L->LQDINDEKSLSHLKSESKEPLKDSEFESLKTCNKSFEEDPKWSNPEPNDLKEENE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TDRD5	Q8NAT2	720	774	722	722	Natural variant	ID=VAR_036706;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs35448215,PMID:15489334
TDRD9	Q8NDG6	140	214	1	1382	Chain	ID=PRO_0000333813;Note=ATP-dependent RNA helicase TDRD9
TDRD9	Q8NDG6	255	282	1	1382	Chain	ID=PRO_0000333813;Note=ATP-dependent RNA helicase TDRD9
TDRD9	Q8NDG6	459	494	1	1382	Chain	ID=PRO_0000333813;Note=ATP-dependent RNA helicase TDRD9
TDRD9	Q8NDG6	684	702	1	1382	Chain	ID=PRO_0000333813;Note=ATP-dependent RNA helicase TDRD9
TDRD9	Q8NDG6	1094	1146	1	1382	Chain	ID=PRO_0000333813;Note=ATP-dependent RNA helicase TDRD9
TDRD9	Q8NDG6	140	214	142	308	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
TDRD9	Q8NDG6	255	282	142	308	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
TDRD9	Q8NDG6	459	494	377	544	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
TDRD9	Q8NDG6	140	214	155	162	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
TDRD9	Q8NDG6	255	282	254	257	Motif	Note=DEAH box;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14BI7
TDRD9	Q8NDG6	1094	1146	1095	1285	Alternative sequence	ID=VSP_033552;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNR	Q92752	1210	1264	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	684	772	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	325	413	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	166	325	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	1210	1264	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	684	772	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	325	413	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	166	325	32	1358	Chain	ID=PRO_0000007747;Note=Tenascin-R
TNR	Q92752	166	325	188	199	Domain	Note=EGF-like 1
TNR	Q92752	166	325	188	199	Domain	Note=EGF-like 1
TNR	Q92752	166	325	219	230	Domain	Note=EGF-like 2
TNR	Q92752	166	325	219	230	Domain	Note=EGF-like 2
TNR	Q92752	166	325	250	261	Domain	Note=EGF-like 3
TNR	Q92752	166	325	250	261	Domain	Note=EGF-like 3
TNR	Q92752	166	325	281	292	Domain	Note=EGF-like 4
TNR	Q92752	166	325	281	292	Domain	Note=EGF-like 4
TNR	Q92752	166	325	312	323	Domain	Note=EGF-like 5
TNR	Q92752	166	325	312	323	Domain	Note=EGF-like 5
TNR	Q92752	325	413	328	420	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNR	Q92752	325	413	328	420	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNR	Q92752	684	772	596	687	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNR	Q92752	684	772	596	687	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNR	Q92752	684	772	688	777	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNR	Q92752	684	772	688	777	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNR	Q92752	1210	1264	1129	1344	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	1210	1264	1129	1344	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	155	314	Compositional bias	Note=Cys-rich
TNR	Q92752	166	325	155	314	Compositional bias	Note=Cys-rich
TNR	Q92752	684	772	724	724	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05546
TNR	Q92752	684	772	724	724	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05546
TNR	Q92752	166	325	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	166	325	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	166	325	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	166	325	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	166	325	278	278	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	166	325	278	278	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	325	413	392	392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	325	413	392	392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	1210	1264	1261	1261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	1210	1264	1261	1261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNR	Q92752	166	325	292	301	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	292	301	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	297	312	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	297	312	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	314	323	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	314	323	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNR	Q92752	166	325	293	293	Natural variant	ID=VAR_021907;Note=G->S;Dbxref=dbSNP:rs3752516
TNR	Q92752	166	325	293	293	Natural variant	ID=VAR_021907;Note=G->S;Dbxref=dbSNP:rs3752516
TNR	Q92752	166	325	302	302	Natural variant	ID=VAR_055780;Note=S->N;Dbxref=dbSNP:rs35736986
TNR	Q92752	166	325	302	302	Natural variant	ID=VAR_055780;Note=S->N;Dbxref=dbSNP:rs35736986
TNS3	Q68CZ2	1257	1283	1	1445	Chain	ID=PRO_0000295915;Note=Tensin-3
TNS3	Q68CZ2	1152	1181	1	1445	Chain	ID=PRO_0000295915;Note=Tensin-3
TNS3	Q68CZ2	341	760	1	1445	Chain	ID=PRO_0000295915;Note=Tensin-3
TNS3	Q68CZ2	306	341	1	1445	Chain	ID=PRO_0000295915;Note=Tensin-3
TNS3	Q68CZ2	50	67	1	1445	Chain	ID=PRO_0000295915;Note=Tensin-3
TNS3	Q68CZ2	50	67	1	170	Domain	Note=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
TNS3	Q68CZ2	1257	1283	1172	1282	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TNS3	Q68CZ2	1152	1181	1172	1282	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TNS3	Q68CZ2	306	341	332	332	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TNS3	Q68CZ2	341	760	361	361	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS3	Q68CZ2	341	760	440	440	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS3	Q68CZ2	341	760	516	516	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS3	Q68CZ2	341	760	571	571	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SSZ5
TNS3	Q68CZ2	341	760	632	632	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TNS3	Q68CZ2	341	760	649	649	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TNS3	Q68CZ2	341	760	660	660	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TNS3	Q68CZ2	341	760	687	687	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SSZ5
TNS3	Q68CZ2	341	760	690	690	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SSZ5
TNS3	Q68CZ2	341	760	735	735	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TNS3	Q68CZ2	1152	1181	1154	1154	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569
TNS3	Q68CZ2	341	760	241	480	Alternative sequence	ID=VSP_027123;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11559528;Dbxref=PMID:11559528
TNS3	Q68CZ2	306	341	241	480	Alternative sequence	ID=VSP_027123;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11559528;Dbxref=PMID:11559528
TNS3	Q68CZ2	1257	1283	251	1445	Alternative sequence	ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS3	Q68CZ2	1152	1181	251	1445	Alternative sequence	ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS3	Q68CZ2	341	760	251	1445	Alternative sequence	ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS3	Q68CZ2	306	341	251	1445	Alternative sequence	ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS3	Q68CZ2	341	760	381	391	Alternative sequence	ID=VSP_027126;Note=In isoform 3. DHSDHTLSVSS->ANVLFELIGQV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNS3	Q68CZ2	1257	1283	392	1445	Alternative sequence	ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNS3	Q68CZ2	1152	1181	392	1445	Alternative sequence	ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNS3	Q68CZ2	341	760	392	1445	Alternative sequence	ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNS3	Q68CZ2	341	760	600	600	Natural variant	ID=VAR_034593;Note=Q->H;Dbxref=dbSNP:rs2293362
TNS3	Q68CZ2	341	760	679	679	Natural variant	ID=VAR_034594;Note=G->S;Dbxref=dbSNP:rs7808646
TNS3	Q68CZ2	341	760	458	458	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNS3	Q68CZ2	341	760	505	505	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEP1	Q99973	2121	2157	1	2627	Chain	ID=PRO_0000050982;Note=Telomerase protein component 1
TEP1	Q99973	1836	1907	1	2627	Chain	ID=PRO_0000050982;Note=Telomerase protein component 1
TEP1	Q99973	842	894	1	2627	Chain	ID=PRO_0000050982;Note=Telomerase protein component 1
TEP1	Q99973	290	344	1	2627	Chain	ID=PRO_0000050982;Note=Telomerase protein component 1
TEP1	Q99973	189	245	1	2627	Chain	ID=PRO_0000050982;Note=Telomerase protein component 1
TEP1	Q99973	290	344	223	676	Domain	Note=TROVE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00343
TEP1	Q99973	189	245	223	676	Domain	Note=TROVE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00343
TEP1	Q99973	1836	1907	1798	1837	Repeat	Note=WD 5
TEP1	Q99973	1836	1907	1840	1879	Repeat	Note=WD 6
TEP1	Q99973	1836	1907	1882	1921	Repeat	Note=WD 7
TEP1	Q99973	2121	2157	2105	2143	Repeat	Note=WD 12
TEP1	Q99973	2121	2157	2146	2183	Repeat	Note=WD 13
TEP1	Q99973	290	344	307	307	Natural variant	ID=VAR_018491;Note=N->K;Dbxref=dbSNP:rs1760898
SNRPE	P62304	27	48	1	92	Chain	ID=PRO_0000125529;Note=Small nuclear ribonucleoprotein E
SNRPE	P62304	27	48	45	45	Natural variant	ID=VAR_069619;Note=In HYPT11%3B does not affect subcellular localization. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246290;Dbxref=dbSNP:rs587776925,PMID:23246290
SNRPE	P62304	27	48	17	27	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
SNRPE	P62304	27	48	30	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
SNRPE	P62304	27	48	39	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
TERF1	P54274	208	258	2	439	Chain	ID=PRO_0000197129;Note=Telomeric repeat-binding factor 1
TERF1	P54274	296	315	2	439	Chain	ID=PRO_0000197129;Note=Telomeric repeat-binding factor 1
TERF1	P54274	208	258	58	268	Region	Note=TRFH dimerization
TERF1	P54274	296	315	265	378	Region	Note=Interaction with RLIM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19164295;Dbxref=PMID:19164295
TERF1	P54274	208	258	219	219	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11375976;Dbxref=PMID:11375976
TERF1	P54274	208	258	213	213	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TERF1	P54274	296	315	296	315	Alternative sequence	ID=VSP_003303;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9326950,ECO:0000303|PubMed:9391075;Dbxref=PMID:15489334,PMID:9326950,PMID:9391075
TERF1	P54274	208	258	219	219	Mutagenesis	Note=Loss of phosphorylation%3B induction of mitotic entry and apoptosis and increased radiation hypersensitivity of ataxia-telangiectasia cells. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11375976;Dbxref=PMID:11375976
TERF1	P54274	208	258	219	219	Mutagenesis	Note=Fails to induce apoptosis and decreases radiation hypersensitivity of ataxia-telangiectasia cells (phospho-mimicking mutants). S->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11375976;Dbxref=PMID:11375976
TERF1	P54274	208	258	211	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BQO
TERF1	P54274	208	258	226	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BQO
TERF1	P54274	208	258	233	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BQO
TERF1	P54274	208	258	252	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H6O
TERF1	P54274	208	258	255	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BQO
RWDD1	Q9H446	182	203	2	243	Chain	ID=PRO_0000097540;Note=RWD domain-containing protein 1
RWDD1	Q9H446	182	203	142	197	Region	Note=Interaction with DRG2;Ontology_term=ECO:0000250;evidence=ECO:0000250
RYR1	P21817	15	55	1	5038	Chain	ID=PRO_0000219358;Note=Ryanodine receptor 1
RYR1	P21817	3969	4004	1	5038	Chain	ID=PRO_0000219358;Note=Ryanodine receptor 1
RYR1	P21817	4553	4582	1	5038	Chain	ID=PRO_0000219358;Note=Ryanodine receptor 1
RYR1	P21817	4788	4837	1	5038	Chain	ID=PRO_0000219358;Note=Ryanodine receptor 1
RYR1	P21817	15	55	1	4559	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	3969	4004	1	4559	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4553	4582	1	4559	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4553	4582	4560	4580	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4553	4582	4581	4641	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4788	4837	4781	4803	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4788	4837	4804	4804	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4788	4837	4805	4821	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4788	4837	4822	4836	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	4788	4837	4837	4857	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11716
RYR1	P21817	15	55	35	35	Natural variant	ID=VAR_005589;Note=In MHS1%3B increases calcium-induced calcium release activity. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16163667,ECO:0000269|PubMed:26115329,ECO:0000269|PubMed:9066328;Dbxref=dbSNP:rs193922747,PMID:16163667,PMID:26115329,PMID:9066328
RYR1	P21817	15	55	40	40	Natural variant	ID=VAR_071721;Note=In MHS1%3B unknown pathological significance. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23558838;Dbxref=PMID:23558838
RYR1	P21817	15	55	44	44	Natural variant	ID=VAR_045695;Note=In CCD and MHS1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12709367;Dbxref=dbSNP:rs193922748,PMID:12709367
RYR1	P21817	4553	4582	4558	4558	Natural variant	ID=VAR_045739;Note=In CCD%3B autosomal recessive form. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17226826,ECO:0000269|PubMed:18253926;Dbxref=dbSNP:rs118192130,PMID:17226826,PMID:18253926
RYR1	P21817	4788	4837	4793	4793	Natural variant	ID=VAR_045751;Note=In CCD. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11709545;Dbxref=dbSNP:rs118192179,PMID:11709545
RYR1	P21817	4788	4837	4796	4796	Natural variant	ID=VAR_045752;Note=In CCD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11709545;Dbxref=dbSNP:rs118192167,PMID:11709545
RYR1	P21817	4788	4837	4806	4806	Natural variant	ID=VAR_076569;Note=In CCD. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234031;Dbxref=dbSNP:rs886039586,PMID:27234031
RYR1	P21817	4788	4837	4814	4814	Natural variant	ID=VAR_045753;Note=In CCD. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14985404;Dbxref=dbSNP:rs118192142,PMID:14985404
RYR1	P21817	4788	4837	4824	4824	Natural variant	ID=VAR_045754;Note=In MHS1. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14985404,ECO:0000269|PubMed:15448513;Dbxref=dbSNP:rs193922874,PMID:14985404,PMID:15448513
RYR1	P21817	4788	4837	4825	4825	Natural variant	ID=VAR_045755;Note=In CCD. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11709545;Dbxref=dbSNP:rs118192180,PMID:11709545
RYR1	P21817	4788	4837	4826	4826	Natural variant	ID=VAR_045756;Note=In MHS1. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10888602,ECO:0000269|PubMed:16163667;Dbxref=dbSNP:rs121918595,PMID:10888602,PMID:16163667
RYR1	P21817	4788	4837	4837	4837	Natural variant	ID=VAR_071753;Note=In MHS1%3B unknown pathological significance. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23558838;Dbxref=PMID:23558838
SLC20A1	Q8WUM9	111	158	1	679	Chain	ID=PRO_0000080771;Note=Sodium-dependent phosphate transporter 1
SLC20A1	Q8WUM9	219	259	1	679	Chain	ID=PRO_0000080771;Note=Sodium-dependent phosphate transporter 1
SLC20A1	Q8WUM9	111	158	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A1	Q8WUM9	111	158	158	178	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A1	Q8WUM9	219	259	203	223	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC20A1	Q8WUM9	219	259	230	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	583	615	1	1083	Chain	ID=PRO_0000178039;Note=Solute carrier family 12 member 7
SLC12A7	Q9Y666	114	163	1	1083	Chain	ID=PRO_0000178039;Note=Solute carrier family 12 member 7
SLC12A7	Q9Y666	114	163	1	118	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	114	163	119	139	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	114	163	141	161	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	114	163	162	214	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	583	615	578	598	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	583	615	599	624	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A7	Q9Y666	583	615	267	1083	Alternative sequence	ID=VSP_006120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC17A5	Q9NRA2	273	326	1	495	Chain	ID=PRO_0000220947;Note=Sialin
SLC17A5	Q9NRA2	204	233	1	495	Chain	ID=PRO_0000220947;Note=Sialin
SLC17A5	Q9NRA2	97	175	1	495	Chain	ID=PRO_0000220947;Note=Sialin
SLC17A5	Q9NRA2	97	175	63	109	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	97	175	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	97	175	131	136	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	97	175	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	97	175	158	158	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	97	175	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	204	233	201	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	204	233	222	227	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	204	233	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	273	326	249	279	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	273	326	280	300	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	273	326	301	328	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A5	Q9NRA2	273	326	274	276	Alternative sequence	ID=VSP_010482;Note=In isoform 2. LSS->AGV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SLC17A5	Q9NRA2	273	326	278	495	Alternative sequence	ID=VSP_010483;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SLC17A5	Q9NRA2	97	175	136	136	Natural variant	ID=VAR_018685;Note=In SD. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10947946;Dbxref=dbSNP:rs80338795,PMID:10947946
SLC17A5	Q9NRA2	273	326	296	296	Natural variant	ID=VAR_034746;Note=V->I;Dbxref=dbSNP:rs16883930
TBL1X	O60907	535	569	1	577	Chain	ID=PRO_0000051263;Note=F-box-like/WD repeat-containing protein TBL1X
TBL1X	O60907	535	569	1	577	Chain	ID=PRO_0000051263;Note=F-box-like/WD repeat-containing protein TBL1X
TBL1X	O60907	535	569	503	542	Repeat	Note=WD 7
TBL1X	O60907	535	569	503	542	Repeat	Note=WD 7
TBL1X	O60907	535	569	544	576	Repeat	Note=WD 8
TBL1X	O60907	535	569	544	576	Repeat	Note=WD 8
MRPS27	Q92552	279	335	37	414	Chain	ID=PRO_0000087712;Note=28S ribosomal protein S27%2C mitochondrial
MRPS27	Q92552	279	335	284	284	Natural variant	ID=VAR_047026;Note=Polymorphism%3B confirmed at protein level. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17488105,ECO:0000269|PubMed:9039502;Dbxref=dbSNP:rs3209157,PMID:17488105,PMID:9039502
RTN4IP1	Q8WWV3	142	165	41	396	Chain	ID=PRO_0000042114;Note=Reticulon-4-interacting protein 1%2C mitochondrial
RTN4IP1	Q8WWV3	142	165	164	164	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RTN4IP1	Q8WWV3	142	165	142	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VN8
RTN4IP1	Q8WWV3	142	165	154	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VN8
RTN4IP1	Q8WWV3	142	165	163	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VN8
RXRG	P48443	147	207	1	463	Chain	ID=PRO_0000053576;Note=Retinoic acid receptor RXR-gamma
RXRG	P48443	147	207	136	211	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
RXRG	P48443	147	207	139	159	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
RXRG	P48443	147	207	175	199	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
RXRG	P48443	147	207	205	230	Region	Note=Hinge
SLC13A4	Q9UKG4	535	581	1	626	Chain	ID=PRO_0000172495;Note=Solute carrier family 13 member 4
SLC13A4	Q9UKG4	535	581	543	563	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A4	Q9UKG4	535	581	539	539	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC13A5	Q86YT5	479	525	1	568	Chain	ID=PRO_0000260101;Note=Solute carrier family 13 member 5
SLC13A5	Q86YT5	425	479	1	568	Chain	ID=PRO_0000260101;Note=Solute carrier family 13 member 5
SLC13A5	Q86YT5	280	351	1	568	Chain	ID=PRO_0000260101;Note=Solute carrier family 13 member 5
SLC13A5	Q86YT5	239	279	1	568	Chain	ID=PRO_0000260101;Note=Solute carrier family 13 member 5
SLC13A5	Q86YT5	239	279	252	272	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A5	Q86YT5	280	351	311	331	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A5	Q86YT5	425	479	406	426	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A5	Q86YT5	425	479	439	459	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A5	Q86YT5	479	525	487	507	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A5	Q86YT5	479	525	479	524	Alternative sequence	ID=VSP_043098;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC13A5	Q86YT5	425	479	479	524	Alternative sequence	ID=VSP_043098;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC13A5	Q86YT5	479	525	341	568	Natural variant	ID=VAR_078915;Note=In EIEE25%3B loss of localization to plasma membrane%3B loss of function in citrate transport. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26384929;Dbxref=PMID:26384929
SLC13A5	Q86YT5	425	479	341	568	Natural variant	ID=VAR_078915;Note=In EIEE25%3B loss of localization to plasma membrane%3B loss of function in citrate transport. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26384929;Dbxref=PMID:26384929
SLC13A5	Q86YT5	280	351	341	568	Natural variant	ID=VAR_078915;Note=In EIEE25%3B loss of localization to plasma membrane%3B loss of function in citrate transport. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26384929;Dbxref=PMID:26384929
SLC13A5	Q86YT5	425	479	427	427	Natural variant	ID=VAR_078916;Note=In EIEE25%3B loss of localization to plasma membrane%3B loss of function in citrate transport. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26384929;Dbxref=dbSNP:rs548065551,PMID:26384929
SLC13A5	Q86YT5	479	525	488	488	Natural variant	ID=VAR_078917;Note=In EIEE25. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24995870;Dbxref=dbSNP:rs587777578,PMID:24995870
SLC13A5	Q86YT5	479	525	524	524	Natural variant	ID=VAR_078918;Note=In EIEE25%3B loss of function in citrate transport%3B no effect on localization to plasma membrane. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26384929;Dbxref=dbSNP:rs863225448,PMID:26384929
SLC13A5	Q86YT5	239	279	269	269	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC13A5	Q86YT5	280	351	330	330	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC13A5	Q86YT5	425	479	475	475	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RYR2	Q92736	3563	3575	1	4967	Chain	ID=PRO_0000219361;Note=Ryanodine receptor 2
RYR2	Q92736	3882	3925	1	4967	Chain	ID=PRO_0000219361;Note=Ryanodine receptor 2
RYR2	Q92736	4492	4521	1	4967	Chain	ID=PRO_0000219361;Note=Ryanodine receptor 2
RYR2	Q92736	4717	4766	1	4967	Chain	ID=PRO_0000219361;Note=Ryanodine receptor 2
RYR2	Q92736	3563	3575	1	4281	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RYR2	Q92736	3882	3925	1	4281	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
RYR2	Q92736	4492	4521	4504	4524	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RYR2	Q92736	4717	4766	4730	4750	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RYR2	Q92736	4492	4521	4497	4497	Natural variant	ID=VAR_011402;Note=In CPVT1. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11208676,ECO:0000269|PubMed:12093772,ECO:0000269|PubMed:15544015;Dbxref=dbSNP:rs121918600,PMID:11208676,PMID:12093772,PMID:15544015
RYR2	Q92736	4492	4521	4499	4499	Natural variant	ID=VAR_044102;Note=In CPVT1. F->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15466642,ECO:0000269|PubMed:16188589;Dbxref=PMID:15466642,PMID:16188589
RYR2	Q92736	4492	4521	4504	4504	Natural variant	ID=VAR_044103;Note=In CPVT1. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15046072;Dbxref=dbSNP:rs1323621379,PMID:15046072
RYR2	Q92736	4492	4521	4510	4510	Natural variant	ID=VAR_044104;Note=In CPVT1. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15466642,ECO:0000269|PubMed:16188589;Dbxref=dbSNP:rs397516510,PMID:15466642,PMID:16188589
SLC12A1	Q13621	209	241	1	1099	Chain	ID=PRO_0000178018;Note=Solute carrier family 12 member 1
SLC12A1	Q13621	561	595	1	1099	Chain	ID=PRO_0000178018;Note=Solute carrier family 12 member 1
SLC12A1	Q13621	209	241	1	1099	Chain	ID=PRO_0000178018;Note=Solute carrier family 12 member 1
SLC12A1	Q13621	561	595	1	1099	Chain	ID=PRO_0000178018;Note=Solute carrier family 12 member 1
SLC12A1	Q13621	209	241	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	209	241	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	209	241	223	259	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	209	241	223	259	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	561	595	551	571	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	561	595	551	571	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	561	595	572	592	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	561	595	572	592	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	561	595	593	609	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	561	595	593	609	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC12A1	Q13621	209	241	214	238	Alternative sequence	ID=VSP_035701;Note=In isoform F. LIILLSTMVTSITGLSTSAIATNGF->IIIGLSVVVTTLTGISMSAICTNGV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8640224;Dbxref=PMID:8640224
SLC12A1	Q13621	209	241	214	238	Alternative sequence	ID=VSP_035701;Note=In isoform F. LIILLSTMVTSITGLSTSAIATNGF->IIIGLSVVVTTLTGISMSAICTNGV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8640224;Dbxref=PMID:8640224
SEC14L4	Q9UDX3	193	221	1	406	Chain	ID=PRO_0000210760;Note=SEC14-like protein 4
SEC14L4	Q9UDX3	58	78	1	406	Chain	ID=PRO_0000210760;Note=SEC14-like protein 4
SEC14L4	Q9UDX3	193	221	76	249	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
SEC14L4	Q9UDX3	58	78	76	249	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
SEC14L4	Q9UDX3	193	221	200	200	Natural variant	ID=VAR_051915;Note=V->M;Dbxref=dbSNP:rs17738540
SEC14L4	Q9UDX3	193	221	211	211	Natural variant	ID=VAR_051916;Note=E->K;Dbxref=dbSNP:rs17738527
SEC14L4	Q9UDX3	58	78	49	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	58	78	68	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	58	78	78	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	193	221	186	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	193	221	198	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	193	221	206	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	193	221	211	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SEC14L4	Q9UDX3	193	221	217	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TLG
SLC35A1	P78382	191	250	1	337	Chain	ID=PRO_0000213351;Note=CMP-sialic acid transporter
SLC35A1	P78382	191	250	176	196	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A1	P78382	191	250	197	212	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A1	P78382	191	250	213	228	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A1	P78382	191	250	229	243	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A1	P78382	191	250	244	262	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A1	P78382	191	250	192	251	Alternative sequence	ID=VSP_042916;Note=In isoform 2. GVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIF->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15576474;Dbxref=PMID:15576474
SLC26A3	P40879	591	669	1	764	Chain	ID=PRO_0000080161;Note=Chloride anion exchanger
SLC26A3	P40879	559	591	1	764	Chain	ID=PRO_0000080161;Note=Chloride anion exchanger
SLC26A3	P40879	245	296	1	764	Chain	ID=PRO_0000080161;Note=Chloride anion exchanger
SLC26A3	P40879	90	127	1	764	Chain	ID=PRO_0000080161;Note=Chloride anion exchanger
SLC26A3	P40879	90	127	77	97	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A3	P40879	90	127	98	99	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A3	P40879	90	127	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A3	P40879	90	127	121	124	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A3	P40879	90	127	125	145	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A3	P40879	245	296	219	257	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A3	P40879	245	296	258	278	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A3	P40879	245	296	279	342	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A3	P40879	591	669	491	701	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A3	P40879	559	591	491	701	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A3	P40879	591	669	525	720	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A3	P40879	559	591	525	720	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A3	P40879	90	127	120	120	Natural variant	ID=VAR_007428;Note=In DIAR1. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28644346,ECO:0000269|PubMed:9554749,ECO:0000269|PubMed:9718329;Dbxref=dbSNP:rs386833479,PMID:28644346,PMID:9554749,PMID:9718329
SLC26A3	P40879	90	127	124	124	Natural variant	ID=VAR_007429;Note=In DIAR1. H->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8896562,ECO:0000269|PubMed:9718329;Dbxref=dbSNP:rs121913030,PMID:8896562,PMID:9718329
SLC26A3	P40879	591	669	652	652	Natural variant	ID=VAR_066075;Note=In DIAR1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19861545;Dbxref=dbSNP:rs140426439,PMID:19861545
SLC26A3	P40879	591	669	654	654	Natural variant	ID=VAR_077361;Note=In DIAR1. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28644346;Dbxref=PMID:28644346
SLC26A5	P58743	559	595	1	744	Chain	ID=PRO_0000080167;Note=Prestin
SLC26A5	P58743	437	469	1	744	Chain	ID=PRO_0000080167;Note=Prestin
SLC26A5	P58743	411	437	1	744	Chain	ID=PRO_0000080167;Note=Prestin
SLC26A5	P58743	245	296	1	744	Chain	ID=PRO_0000080167;Note=Prestin
SLC26A5	P58743	245	296	233	253	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	245	296	254	274	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	245	296	275	286	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	245	296	287	307	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	411	437	396	411	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	411	437	412	432	Transmembrane	Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	437	469	433	441	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	411	437	433	441	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	437	469	442	462	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	437	469	463	479	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	559	595	501	744	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A5	P58743	559	595	525	713	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A5	P58743	559	595	336	744	Alternative sequence	ID=VSP_010191;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12719379;Dbxref=PMID:12719379
SLC26A5	P58743	437	469	336	744	Alternative sequence	ID=VSP_010191;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12719379;Dbxref=PMID:12719379
SLC26A5	P58743	411	437	336	744	Alternative sequence	ID=VSP_010191;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12719379;Dbxref=PMID:12719379
SLC26A5	P58743	437	469	438	469	Alternative sequence	ID=VSP_043153;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
SLC26A5	P58743	559	595	517	744	Alternative sequence	ID=VSP_010193;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12719379;Dbxref=PMID:12719379
SLC26A5	P58743	559	595	595	595	Alternative sequence	ID=VSP_047640;Note=In isoform 6. A->ATQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SLC47A1	Q96FL8	45	79	1	570	Chain	ID=PRO_0000312845;Note=Multidrug and toxin extrusion protein 1
SLC47A1	Q96FL8	79	102	1	570	Chain	ID=PRO_0000312845;Note=Multidrug and toxin extrusion protein 1
SLC47A1	Q96FL8	166	181	1	570	Chain	ID=PRO_0000312845;Note=Multidrug and toxin extrusion protein 1
SLC47A1	Q96FL8	246	284	1	570	Chain	ID=PRO_0000312845;Note=Multidrug and toxin extrusion protein 1
SLC47A1	Q96FL8	45	79	38	58	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	45	79	59	72	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	45	79	73	93	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	79	102	73	93	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	79	102	94	123	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	166	181	153	173	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	166	181	174	176	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	166	181	177	197	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	246	284	238	256	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	246	284	257	276	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	246	284	277	295	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A1	Q96FL8	246	284	273	273	Mutagenesis	Note=No change in subcellular location and abolition of MATE1-dependent TEA transport activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16330770;Dbxref=PMID:16330770
SLC47A1	Q96FL8	45	79	50	50	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRD5A1	P18405	153	187	1	259	Chain	ID=PRO_0000213674;Note=3-oxo-5-alpha-steroid 4-dehydrogenase 1
SRD5A1	P18405	153	187	151	171	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A11	Q8NBS3	405	443	1	891	Chain	ID=PRO_0000079236;Note=Sodium bicarbonate transporter-like protein 11
SLC4A11	Q8NBS3	405	443	416	436	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A11	Q8NBS3	405	443	376	891	Region	Note=Membrane (bicarbonate transporter)
SLC4A11	Q8NBS3	405	443	1	482	Alternative sequence	ID=VSP_035891;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC4A11	Q8NBS3	405	443	408	408	Natural variant	ID=VAR_015521;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11302728;Dbxref=PMID:11302728
SLC4A11	Q8NBS3	405	443	409	409	Natural variant	ID=VAR_015522;Note=K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11302728;Dbxref=PMID:11302728
SLC4A11	Q8NBS3	405	443	418	418	Natural variant	ID=VAR_064983;Note=In CHED. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17679935,ECO:0000269|PubMed:19369245;Dbxref=PMID:17679935,PMID:19369245
SLC4A11	Q8NBS3	405	443	434	434	Natural variant	ID=VAR_075538;Note=In FECD4%3B decreases cell surface expression%3B highly reduces functional activity. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25007886;Dbxref=PMID:25007886
SLC45A1	Q9Y2W3	132	163	1	782	Chain	ID=PRO_0000122514;Note=Proton-associated sugar transporter A
SLC45A1	Q9Y2W3	132	163	127	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC45A1	Q9Y2W3	132	163	157	177	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SAT2	Q96F10	67	101	1	170	Chain	ID=PRO_0000074598;Note=Diamine acetyltransferase 2
SAT2	Q96F10	67	101	4	168	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
SAT2	Q96F10	67	101	94	96	Region	Note=Acetyl-CoA binding
SAT2	Q96F10	67	101	92	92	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAT2	Q96F10	67	101	70	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BEI
SAT2	Q96F10	67	101	83	85	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BEI
SAT2	Q96F10	67	101	86	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BEI
SAT2	Q96F10	67	101	98	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BEI
SBDS	Q9Y3A5	153	208	2	250	Chain	ID=PRO_0000123762;Note=Ribosome maturation protein SBDS
SBDS	Q9Y3A5	86	153	2	250	Chain	ID=PRO_0000123762;Note=Ribosome maturation protein SBDS
SBDS	Q9Y3A5	86	153	87	87	Natural variant	ID=VAR_015393;Note=In SDS1%3B unknown pathological significance. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12496757;Dbxref=PMID:12496757
SBDS	Q9Y3A5	86	153	126	126	Natural variant	ID=VAR_015394;Note=In SDS1%3B strongly reduced release of EIF6 from pre-60S ribosome subunits. R->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12496757,ECO:0000269|PubMed:21536732;Dbxref=dbSNP:rs113993995,PMID:12496757,PMID:21536732
SBDS	Q9Y3A5	153	208	169	169	Natural variant	ID=VAR_015395;Note=In SDS1%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12496757;Dbxref=dbSNP:rs113993996,PMID:12496757
SBDS	Q9Y3A5	86	153	151	151	Mutagenesis	Note=Strongly reduced release of EIF6 from pre-60S ribosome subunits. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21536732;Dbxref=PMID:21536732
SBDS	Q9Y3A5	86	153	89	89	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBDS	Q9Y3A5	86	153	105	105	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBDS	Q9Y3A5	86	153	114	114	Sequence conflict	Note=I->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBDS	Q9Y3A5	86	153	126	126	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBDS	Q9Y3A5	86	153	143	143	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBDS	Q9Y3A5	86	153	146	146	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBDS	Q9Y3A5	86	153	80	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	91	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	97	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	130	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	150	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	86	153	150	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	170	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	194	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBDS	Q9Y3A5	153	208	207	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5AN9
SBNO1	A3KN83	1210	1256	1	1393	Chain	ID=PRO_0000314555;Note=Protein strawberry notch homolog 1
SBNO1	A3KN83	1073	1098	1	1393	Chain	ID=PRO_0000314555;Note=Protein strawberry notch homolog 1
SBNO1	A3KN83	1210	1256	1	1393	Chain	ID=PRO_0000314555;Note=Protein strawberry notch homolog 1
SBNO1	A3KN83	1073	1098	1	1393	Chain	ID=PRO_0000314555;Note=Protein strawberry notch homolog 1
SBNO1	A3KN83	44	79	1	1393	Chain	ID=PRO_0000314555;Note=Protein strawberry notch homolog 1
SBNO1	A3KN83	0	44	1	1393	Chain	ID=PRO_0000314555;Note=Protein strawberry notch homolog 1
SBNO1	A3KN83	1210	1256	1222	1222	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SBNO1	A3KN83	1210	1256	1222	1222	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SBNO1	A3KN83	44	79	78	79	Alternative sequence	ID=VSP_030295;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SBNO1	A3KN83	1210	1256	734	1393	Alternative sequence	ID=VSP_030298;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16533400;Dbxref=PMID:16533400
SBNO1	A3KN83	1073	1098	734	1393	Alternative sequence	ID=VSP_030298;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16533400;Dbxref=PMID:16533400
SBNO1	A3KN83	1210	1256	734	1393	Alternative sequence	ID=VSP_030298;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16533400;Dbxref=PMID:16533400
SBNO1	A3KN83	1073	1098	734	1393	Alternative sequence	ID=VSP_030298;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16533400;Dbxref=PMID:16533400
SBNO1	A3KN83	0	44	4	4	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SBNO1	A3KN83	0	44	14	14	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC22A	Q96IW7	219	241	2	307	Chain	ID=PRO_0000253043;Note=Vesicle-trafficking protein SEC22a
SEC22A	Q96IW7	219	241	2	307	Chain	ID=PRO_0000253043;Note=Vesicle-trafficking protein SEC22a
SEC22A	Q96IW7	219	241	209	226	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC22A	Q96IW7	219	241	209	226	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC22A	Q96IW7	219	241	227	247	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC22A	Q96IW7	219	241	227	247	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC11A	P67812	104	143	1	179	Chain	ID=PRO_0000109543;Note=Signal peptidase complex catalytic subunit SEC11A
SEC11A	P67812	54	103	1	179	Chain	ID=PRO_0000109543;Note=Signal peptidase complex catalytic subunit SEC11A
SEC11A	P67812	104	143	37	179	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC11A	P67812	54	103	37	179	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC11A	P67812	54	103	56	56	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEC23B	Q15437	122	201	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	411	438	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	438	468	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	635	664	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	716	738	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	122	201	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	411	438	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	438	468	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	635	664	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	716	738	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	122	201	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	411	438	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	438	468	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	635	664	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	716	738	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	122	201	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	411	438	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	438	468	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	635	664	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	716	738	2	767	Chain	ID=PRO_0000205148;Note=Protein transport protein Sec23B
SEC23B	Q15437	635	664	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	716	738	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	635	664	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	716	738	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	635	664	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	716	738	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	635	664	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	716	738	634	720	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23B	Q15437	122	201	164	164	Natural variant	ID=VAR_076424;Note=In CWS7%3B unknown pathological significance. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522472;Dbxref=dbSNP:rs36023150,PMID:26522472
SEC23B	Q15437	122	201	164	164	Natural variant	ID=VAR_076424;Note=In CWS7%3B unknown pathological significance. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522472;Dbxref=dbSNP:rs36023150,PMID:26522472
SEC23B	Q15437	122	201	164	164	Natural variant	ID=VAR_076424;Note=In CWS7%3B unknown pathological significance. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522472;Dbxref=dbSNP:rs36023150,PMID:26522472
SEC23B	Q15437	122	201	164	164	Natural variant	ID=VAR_076424;Note=In CWS7%3B unknown pathological significance. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522472;Dbxref=dbSNP:rs36023150,PMID:26522472
SEC23B	Q15437	411	438	426	426	Natural variant	ID=VAR_062303;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs41309927,PMID:19561605
SEC23B	Q15437	411	438	426	426	Natural variant	ID=VAR_062303;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs41309927,PMID:19561605
SEC23B	Q15437	411	438	426	426	Natural variant	ID=VAR_062303;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs41309927,PMID:19561605
SEC23B	Q15437	411	438	426	426	Natural variant	ID=VAR_062303;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs41309927,PMID:19561605
SEC23B	Q15437	411	438	433	433	Natural variant	ID=VAR_034482;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17807673,PMID:15489334
SEC23B	Q15437	411	438	433	433	Natural variant	ID=VAR_034482;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17807673,PMID:15489334
SEC23B	Q15437	411	438	433	433	Natural variant	ID=VAR_034482;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17807673,PMID:15489334
SEC23B	Q15437	411	438	433	433	Natural variant	ID=VAR_034482;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17807673,PMID:15489334
SEC23B	Q15437	438	468	462	462	Natural variant	ID=VAR_062304;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs780978419,PMID:19561605
SEC23B	Q15437	438	468	462	462	Natural variant	ID=VAR_062304;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs780978419,PMID:19561605
SEC23B	Q15437	438	468	462	462	Natural variant	ID=VAR_062304;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs780978419,PMID:19561605
SEC23B	Q15437	438	468	462	462	Natural variant	ID=VAR_062304;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19561605;Dbxref=dbSNP:rs780978419,PMID:19561605
SLC5A6	Q9Y289	245	291	1	635	Chain	ID=PRO_0000105386;Note=Sodium-dependent multivitamin transporter
SLC5A6	Q9Y289	131	153	1	635	Chain	ID=PRO_0000105386;Note=Sodium-dependent multivitamin transporter
SLC5A6	Q9Y289	245	291	1	635	Chain	ID=PRO_0000105386;Note=Sodium-dependent multivitamin transporter
SLC5A6	Q9Y289	131	153	1	635	Chain	ID=PRO_0000105386;Note=Sodium-dependent multivitamin transporter
SLC5A6	Q9Y289	131	153	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A6	Q9Y289	131	153	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A6	Q9Y289	245	291	256	276	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A6	Q9Y289	245	291	256	276	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A6	Q9Y289	131	153	138	138	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A6	Q9Y289	131	153	138	138	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A8	P48029	259	304	1	635	Chain	ID=PRO_0000214774;Note=Sodium- and chloride-dependent creatine transporter 1
SLC6A8	P48029	418	464	1	635	Chain	ID=PRO_0000214774;Note=Sodium- and chloride-dependent creatine transporter 1
SLC6A8	P48029	259	304	252	269	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A8	P48029	259	304	270	290	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A8	P48029	259	304	291	304	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A8	P48029	418	464	416	444	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A8	P48029	418	464	445	465	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A8	P48029	259	304	1	365	Alternative sequence	ID=VSP_043916;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18515020;Dbxref=PMID:18515020
SLC6A8	P48029	259	304	1	259	Alternative sequence	ID=VSP_043917;Note=In isoform 2. MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGK->MLPTLQIQGPAAFAPGDRGPGRHCPFPVPITPTGALLPVSDSCDSLVDLVWPSVTYLALGTQSRVWPHPLGAPGQAGESPEQRRQCLELWDMASSLGDKVPRAACGKRGQTVWQLHLACLCLAQFHSPPAQPPPLSRRGGGPDPDPISRSLPGPPTPALPTHSYSSHSPRAPRLLSPLRRAPRGSPAPHRHASLQTNEAPRELPHCTWPGLPGRSLAPSFLWREPWLGGQWGPLNIPARKGDRRRWEWGCEGGGATASAEQPGPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7622069;Dbxref=PMID:7622069
SLC6A8	P48029	418	464	464	464	Alternative sequence	ID=VSP_043919;Note=In isoform 2. D->DVSGVGGLPVTSGGRLPSSLTGLCPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7622069;Dbxref=PMID:7622069
SLC6A8	P48029	259	304	270	270	Natural variant	ID=VAR_074263;Note=Polymorphism%3B no effect on creatine transporter activity. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25861866;Dbxref=dbSNP:rs146985734,PMID:25861866
SLC6A8	P48029	259	304	294	294	Natural variant	ID=VAR_074264;Note=Polymorphism%3B no effect on creatine transporter activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25861866;Dbxref=dbSNP:rs376937460,PMID:25861866
SLC6A8	P48029	418	464	448	448	Natural variant	ID=VAR_071793;Note=In CCDS1. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23660394;Dbxref=PMID:23660394
SLC6A8	P48029	259	304	285	285	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC6A8	P48029	418	464	434	434	Sequence conflict	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC6A1	P30531	397	441	1	599	Chain	ID=PRO_0000214743;Note=Sodium- and chloride-dependent GABA transporter 1
SLC6A1	P30531	509	565	1	599	Chain	ID=PRO_0000214743;Note=Sodium- and chloride-dependent GABA transporter 1
SLC6A1	P30531	397	441	422	440	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A1	P30531	509	565	498	517	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A1	P30531	509	565	536	554	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A1	P30531	509	565	555	599	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A1	P30531	509	565	521	521	Natural variant	ID=VAR_055088;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855574,PMID:15489334
SLC6A1	P30531	509	565	558	558	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCEL	O95171	97	119	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	120	132	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	160	181	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	209	230	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	231	250	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	251	265	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	266	285	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	326	345	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	366	385	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	386	405	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	463	483	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	484	503	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	504	523	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	524	542	1	688	Chain	ID=PRO_0000075903;Note=Sciellin
SCEL	O95171	251	265	251	266	Repeat	Note=1
SCEL	O95171	266	285	251	266	Repeat	Note=1
SCEL	O95171	266	285	267	286	Repeat	Note=2
SCEL	O95171	326	345	307	326	Repeat	Note=4
SCEL	O95171	326	345	327	346	Repeat	Note=5
SCEL	O95171	366	385	347	366	Repeat	Note=6
SCEL	O95171	366	385	367	386	Repeat	Note=7
SCEL	O95171	386	405	367	386	Repeat	Note=7
SCEL	O95171	386	405	387	406	Repeat	Note=8
SCEL	O95171	463	483	447	465	Repeat	Note=11
SCEL	O95171	463	483	466	484	Repeat	Note=12
SCEL	O95171	484	503	466	484	Repeat	Note=12
SCEL	O95171	484	503	485	504	Repeat	Note=13
SCEL	O95171	504	523	485	504	Repeat	Note=13
SCEL	O95171	504	523	505	523	Repeat	Note=14
SCEL	O95171	524	542	524	543	Repeat	Note=15
SCEL	O95171	251	265	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	266	285	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	326	345	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	366	385	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	386	405	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	463	483	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	484	503	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	504	523	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	524	542	251	563	Region	Note=16 X approximate tandem repeats
SCEL	O95171	386	405	389	389	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9EQG3
SCEL	O95171	160	181	160	181	Alternative sequence	ID=VSP_045288;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCEL	O95171	231	250	231	251	Alternative sequence	ID=VSP_035980;Note=In isoform 2. RSQDLDNIVKVATSLQRSDKG->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9813070;Dbxref=PMID:15489334,PMID:9813070
SCEL	O95171	251	265	231	251	Alternative sequence	ID=VSP_035980;Note=In isoform 2. RSQDLDNIVKVATSLQRSDKG->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9813070;Dbxref=PMID:15489334,PMID:9813070
SCEL	O95171	366	385	367	386	Alternative sequence	ID=VSP_045289;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCEL	O95171	386	405	367	386	Alternative sequence	ID=VSP_045289;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCEL	O95171	326	345	336	336	Natural variant	ID=VAR_047920;Note=V->L;Dbxref=dbSNP:rs34164479
SCEL	O95171	386	405	386	386	Natural variant	ID=VAR_047921;Note=R->K;Dbxref=dbSNP:rs2274016
SCEL	O95171	463	483	480	480	Natural variant	ID=VAR_047922;Note=K->R;Dbxref=dbSNP:rs8002725
SCEL	O95171	120	132	124	124	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCEL	O95171	326	345	337	337	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCEL	O95171	326	345	340	340	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCAPER	Q9BY12	1235	1285	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	1104	1155	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	882	903	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	575	622	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	65	131	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	1235	1285	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	1104	1155	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	882	903	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	575	622	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	65	131	1	1400	Chain	ID=PRO_0000047513;Note=S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER	Q9BY12	575	622	395	770	Compositional bias	Note=Glu-rich
SCAPER	Q9BY12	575	622	395	770	Compositional bias	Note=Glu-rich
SCAPER	Q9BY12	65	131	1	257	Alternative sequence	ID=VSP_046503;Note=In isoform 3. MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTDAQSRPTSLAWEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWADKVKAHHTGSTASSEITPAQSCPPMTVQKASRKN->MKTKYIFCNIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SCAPER	Q9BY12	65	131	1	257	Alternative sequence	ID=VSP_046503;Note=In isoform 3. MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTDAQSRPTSLAWEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWADKVKAHHTGSTASSEITPAQSCPPMTVQKASRKN->MKTKYIFCNIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SCAPER	Q9BY12	1235	1285	1236	1244	Alternative sequence	ID=VSP_031442;Note=In isoform 2. SIVGAEGLS->VPSIGLYRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
SCAPER	Q9BY12	1235	1285	1236	1244	Alternative sequence	ID=VSP_031442;Note=In isoform 2. SIVGAEGLS->VPSIGLYRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
SCAPER	Q9BY12	1235	1285	1245	1400	Alternative sequence	ID=VSP_031443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
SCAPER	Q9BY12	1235	1285	1245	1400	Alternative sequence	ID=VSP_031443;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
SCAPER	Q9BY12	1104	1155	1139	1139	Natural variant	ID=VAR_059910;Note=A->T;Dbxref=dbSNP:rs3743176
SCAPER	Q9BY12	1104	1155	1139	1139	Natural variant	ID=VAR_059910;Note=A->T;Dbxref=dbSNP:rs3743176
SCAPER	Q9BY12	1104	1155	1140	1140	Natural variant	ID=VAR_052806;Note=A->T;Dbxref=dbSNP:rs3743176
SCAPER	Q9BY12	1104	1155	1140	1140	Natural variant	ID=VAR_052806;Note=A->T;Dbxref=dbSNP:rs3743176
SCAPER	Q9BY12	1235	1285	1262	1262	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCAPER	Q9BY12	1235	1285	1262	1262	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCMH1	Q96GD3	549	571	1	660	Chain	ID=PRO_0000114334;Note=Polycomb protein SCMH1
SCMH1	Q96GD3	425	489	1	660	Chain	ID=PRO_0000114334;Note=Polycomb protein SCMH1
SCMH1	Q96GD3	358	425	1	660	Chain	ID=PRO_0000114334;Note=Polycomb protein SCMH1
SCMH1	Q96GD3	469	529	1	660	Chain	ID=PRO_0000114334;Note=Polycomb protein SCMH1
SCMH1	Q96GD3	405	469	1	660	Chain	ID=PRO_0000114334;Note=Polycomb protein SCMH1
SCMH1	Q96GD3	338	405	1	660	Chain	ID=PRO_0000114334;Note=Polycomb protein SCMH1
SCMH1	Q96GD3	549	571	550	571	Alternative sequence	ID=VSP_051679;Note=In isoform 2%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10524249,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:10524249,PMID:14702039,PMID:17974005
SCMH1	Q96GD3	425	489	463	463	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCMH1	Q96GD3	405	469	463	463	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCML2	Q9UQR0	424	485	1	700	Chain	ID=PRO_0000097628;Note=Sex comb on midleg-like protein 2
SCML2	Q9UQR0	424	485	1	562	Alternative sequence	ID=VSP_010277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SCML2	Q9UQR0	424	485	422	427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MEM
SCML2	Q9UQR0	424	485	430	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MEM
SCML2	Q9UQR0	424	485	442	455	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MEM
SCN1A	P35498	1334	1428	1	2009	Chain	ID=PRO_0000048489;Note=Sodium channel protein type 1 subunit alpha
SCN1A	P35498	1334	1428	1	2009	Chain	ID=PRO_0000048489;Note=Sodium channel protein type 1 subunit alpha
SCN1A	P35498	1334	1428	1330	1346	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN1A	P35498	1334	1428	1330	1346	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN1A	P35498	1334	1428	1347	1366	Transmembrane	Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN1A	P35498	1334	1428	1347	1366	Transmembrane	Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN1A	P35498	1334	1428	1367	1418	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN1A	P35498	1334	1428	1367	1418	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN1A	P35498	1334	1428	1419	1440	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN1A	P35498	1334	1428	1419	1440	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN1A	P35498	1334	1428	1200	1514	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN1A	P35498	1334	1428	1200	1514	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN1A	P35498	1334	1428	1378	1378	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN1A	P35498	1334	1428	1378	1378	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN1A	P35498	1334	1428	1392	1392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN1A	P35498	1334	1428	1392	1392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN1A	P35498	1334	1428	1403	1403	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN1A	P35498	1334	1428	1403	1403	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN1A	P35498	1334	1428	450	2009	Natural variant	ID=VAR_078726;Note=In EIEE6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25818041;Dbxref=PMID:25818041
SCN1A	P35498	1334	1428	450	2009	Natural variant	ID=VAR_078726;Note=In EIEE6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25818041;Dbxref=PMID:25818041
SCN1A	P35498	1334	1428	1284	2009	Natural variant	ID=VAR_078727;Note=In EIEE6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN1A	P35498	1334	1428	1284	2009	Natural variant	ID=VAR_078727;Note=In EIEE6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN1A	P35498	1334	1428	1335	1335	Natural variant	ID=VAR_043362;Note=In EIEE6. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18413471,ECO:0000269|PubMed:20431604;Dbxref=dbSNP:rs121917960,PMID:18413471,PMID:20431604
SCN1A	P35498	1334	1428	1335	1335	Natural variant	ID=VAR_043362;Note=In EIEE6. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18413471,ECO:0000269|PubMed:20431604;Dbxref=dbSNP:rs121917960,PMID:18413471,PMID:20431604
SCN1A	P35498	1334	1428	1339	1339	Natural variant	ID=VAR_073557;Note=In EIEE6. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22092154,ECO:0000269|PubMed:23195492;Dbxref=dbSNP:rs794726789,PMID:22092154,PMID:23195492
SCN1A	P35498	1334	1428	1339	1339	Natural variant	ID=VAR_073557;Note=In EIEE6. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22092154,ECO:0000269|PubMed:23195492;Dbxref=dbSNP:rs794726789,PMID:22092154,PMID:23195492
SCN1A	P35498	1334	1428	1344	1344	Natural variant	ID=VAR_073558;Note=In EIEE6. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1344	1344	Natural variant	ID=VAR_073558;Note=In EIEE6. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1345	1345	Natural variant	ID=VAR_078728;Note=In EIEE6. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN1A	P35498	1334	1428	1345	1345	Natural variant	ID=VAR_078728;Note=In EIEE6. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN1A	P35498	1334	1428	1350	1350	Natural variant	ID=VAR_073559;Note=In EIEE6. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1350	1350	Natural variant	ID=VAR_073559;Note=In EIEE6. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1353	1353	Natural variant	ID=VAR_014272;Note=In GEFS+2%3B complete loss of function. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11254444,ECO:0000269|PubMed:14672992;Dbxref=dbSNP:rs121917954,PMID:11254444,PMID:14672992
SCN1A	P35498	1334	1428	1353	1353	Natural variant	ID=VAR_014272;Note=In GEFS+2%3B complete loss of function. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11254444,ECO:0000269|PubMed:14672992;Dbxref=dbSNP:rs121917954,PMID:11254444,PMID:14672992
SCN1A	P35498	1334	1428	1355	1355	Natural variant	ID=VAR_029697;Note=In EIEE6. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14738421,ECO:0000269|PubMed:23195492;Dbxref=dbSNP:rs121918776,PMID:14738421,PMID:23195492
SCN1A	P35498	1334	1428	1355	1355	Natural variant	ID=VAR_029697;Note=In EIEE6. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14738421,ECO:0000269|PubMed:23195492;Dbxref=dbSNP:rs121918776,PMID:14738421,PMID:23195492
SCN1A	P35498	1334	1428	1357	1357	Natural variant	ID=VAR_073560;Note=In ICEGTC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1357	1357	Natural variant	ID=VAR_073560;Note=In ICEGTC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1358	1358	Natural variant	ID=VAR_073561;Note=In EIEE6. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1358	1358	Natural variant	ID=VAR_073561;Note=In EIEE6. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1358	1358	Natural variant	ID=VAR_043363;Note=In EIEE6. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18413471;Dbxref=dbSNP:rs121917961,PMID:18413471
SCN1A	P35498	1334	1428	1358	1358	Natural variant	ID=VAR_043363;Note=In EIEE6. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18413471;Dbxref=dbSNP:rs121917961,PMID:18413471
SCN1A	P35498	1334	1428	1366	1366	Natural variant	ID=VAR_043364;Note=In GEFS+2 and ICEGTC. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17507202;Dbxref=dbSNP:rs121918805,PMID:17507202
SCN1A	P35498	1334	1428	1366	1366	Natural variant	ID=VAR_043364;Note=In GEFS+2 and ICEGTC. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17507202;Dbxref=dbSNP:rs121918805,PMID:17507202
SCN1A	P35498	1334	1428	1367	1367	Natural variant	ID=VAR_064259;Note=In EIEE6. N->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18930999,ECO:0000269|PubMed:20522430;Dbxref=dbSNP:rs121918760,PMID:18930999,PMID:20522430
SCN1A	P35498	1334	1428	1367	1367	Natural variant	ID=VAR_064259;Note=In EIEE6. N->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18930999,ECO:0000269|PubMed:20522430;Dbxref=dbSNP:rs121918760,PMID:18930999,PMID:20522430
SCN1A	P35498	1334	1428	1370	1370	Natural variant	ID=VAR_073562;Note=In EIEE6%3B borderline phenotype. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1370	1370	Natural variant	ID=VAR_073562;Note=In EIEE6%3B borderline phenotype. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1376	1376	Natural variant	ID=VAR_073563;Note=In ICEGTC. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1376	1376	Natural variant	ID=VAR_073563;Note=In ICEGTC. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1378	1378	Natural variant	ID=VAR_073564;Note=In EIEE6. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1378	1378	Natural variant	ID=VAR_073564;Note=In EIEE6. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1378	1378	Natural variant	ID=VAR_073565;Note=In EIEE6. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=dbSNP:rs1131691775,PMID:21248271
SCN1A	P35498	1334	1428	1378	1378	Natural variant	ID=VAR_073565;Note=In EIEE6. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=dbSNP:rs1131691775,PMID:21248271
SCN1A	P35498	1334	1428	1385	1385	Natural variant	ID=VAR_073566;Note=In EIEE6. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1385	1385	Natural variant	ID=VAR_073566;Note=In EIEE6. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1390	1390	Natural variant	ID=VAR_029699;Note=In EIEE6%3B some patients have a borderline EIEE6 phenotype. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12083760,ECO:0000269|PubMed:17347258,ECO:0000269|PubMed:20431604;Dbxref=dbSNP:rs121917986,PMID:12083760,PMID:17347258,PMID:20431604
SCN1A	P35498	1334	1428	1390	1390	Natural variant	ID=VAR_029699;Note=In EIEE6%3B some patients have a borderline EIEE6 phenotype. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12083760,ECO:0000269|PubMed:17347258,ECO:0000269|PubMed:20431604;Dbxref=dbSNP:rs121917986,PMID:12083760,PMID:17347258,PMID:20431604
SCN1A	P35498	1334	1428	1391	1391	Natural variant	ID=VAR_073567;Note=In EIEE6. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18930999;Dbxref=PMID:18930999
SCN1A	P35498	1334	1428	1391	1391	Natural variant	ID=VAR_073567;Note=In EIEE6. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18930999;Dbxref=PMID:18930999
SCN1A	P35498	1334	1428	1393	1393	Natural variant	ID=VAR_073568;Note=In EIEE6%3B borderline phenotype. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17129991;Dbxref=PMID:17129991
SCN1A	P35498	1334	1428	1393	1393	Natural variant	ID=VAR_073568;Note=In EIEE6%3B borderline phenotype. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17129991;Dbxref=PMID:17129991
SCN1A	P35498	1334	1428	1394	1394	Natural variant	ID=VAR_073569;Note=In EIEE6. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1394	1394	Natural variant	ID=VAR_073569;Note=In EIEE6. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1396	1396	Natural variant	ID=VAR_064260;Note=In EIEE6%3B some patients have a borderline EIEE6 phenotype. C->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16713920,ECO:0000269|PubMed:17347258,ECO:0000269|PubMed:19589774;Dbxref=dbSNP:rs121917987,PMID:16713920,PMID:17347258,PMID:19589774
SCN1A	P35498	1334	1428	1396	1396	Natural variant	ID=VAR_064260;Note=In EIEE6%3B some patients have a borderline EIEE6 phenotype. C->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16713920,ECO:0000269|PubMed:17347258,ECO:0000269|PubMed:19589774;Dbxref=dbSNP:rs121917987,PMID:16713920,PMID:17347258,PMID:19589774
SCN1A	P35498	1334	1428	1396	1396	Natural variant	ID=VAR_073570;Note=In EIEE6. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1396	1396	Natural variant	ID=VAR_073570;Note=In EIEE6. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1414	1414	Natural variant	ID=VAR_073571;Note=In GEFS+2. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1414	1414	Natural variant	ID=VAR_073571;Note=In GEFS+2. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1414	1414	Natural variant	ID=VAR_064312;Note=In EIEE6. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17561957;Dbxref=dbSNP:rs121917925,PMID:17561957
SCN1A	P35498	1334	1428	1414	1414	Natural variant	ID=VAR_064312;Note=In EIEE6. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17561957;Dbxref=dbSNP:rs121917925,PMID:17561957
SCN1A	P35498	1334	1428	1416	1416	Natural variant	ID=VAR_073572;Note=In EIEE6. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18930999;Dbxref=PMID:18930999
SCN1A	P35498	1334	1428	1416	1416	Natural variant	ID=VAR_073572;Note=In EIEE6. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18930999;Dbxref=PMID:18930999
SCN1A	P35498	1334	1428	1417	1417	Natural variant	ID=VAR_073573;Note=In EIEE6. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1417	1417	Natural variant	ID=VAR_073573;Note=In EIEE6. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1418	1418	Natural variant	ID=VAR_073574;Note=In EIEE6. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1418	1418	Natural variant	ID=VAR_073574;Note=In EIEE6. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1422	1422	Natural variant	ID=VAR_064313;Note=In EIEE6. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17054684;Dbxref=dbSNP:rs121917913,PMID:17054684
SCN1A	P35498	1334	1428	1422	1422	Natural variant	ID=VAR_064313;Note=In EIEE6. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17054684;Dbxref=dbSNP:rs121917913,PMID:17054684
SCN1A	P35498	1334	1428	1423	1423	Natural variant	ID=VAR_073575;Note=In EIEE6. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1423	1423	Natural variant	ID=VAR_073575;Note=In EIEE6. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248271;Dbxref=PMID:21248271
SCN1A	P35498	1334	1428	1426	1426	Natural variant	ID=VAR_064314;Note=In EIEE6. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17054684;Dbxref=dbSNP:rs121917944,PMID:17054684
SCN1A	P35498	1334	1428	1426	1426	Natural variant	ID=VAR_064314;Note=In EIEE6. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17054684;Dbxref=dbSNP:rs121917944,PMID:17054684
SCN1A	P35498	1334	1428	1427	1427	Natural variant	ID=VAR_073576;Note=In EIEE6. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1427	1427	Natural variant	ID=VAR_073576;Note=In EIEE6. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23195492;Dbxref=PMID:23195492
SCN1A	P35498	1334	1428	1428	1428	Natural variant	ID=VAR_029700;Note=In GEFS+2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524484;Dbxref=dbSNP:rs121918627,PMID:11524484
SCN1A	P35498	1334	1428	1428	1428	Natural variant	ID=VAR_029700;Note=In GEFS+2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11524484;Dbxref=dbSNP:rs121918627,PMID:11524484
TBK1	Q9UHD2	29	76	1	729	Chain	ID=PRO_0000086743;Note=Serine/threonine-protein kinase TBK1
TBK1	Q9UHD2	447	480	1	729	Chain	ID=PRO_0000086743;Note=Serine/threonine-protein kinase TBK1
TBK1	Q9UHD2	689	712	1	729	Chain	ID=PRO_0000086743;Note=Serine/threonine-protein kinase TBK1
TBK1	Q9UHD2	29	76	9	310	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TBK1	Q9UHD2	447	480	407	657	Coiled coil	.
TBK1	Q9UHD2	689	712	658	713	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TBK1	Q9UHD2	29	76	38	38	Binding site	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBK1	Q9UHD2	29	76	30	30	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453971;Dbxref=PMID:23453971
TBK1	Q9UHD2	29	76	47	47	Natural variant	ID=VAR_073938;Note=In FTDALS4%3B loss of kinase activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25803835;Dbxref=PMID:25803835
TBK1	Q9UHD2	29	76	50	50	Natural variant	ID=VAR_080517;Note=In IIAE8%3B decreased expression levels. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22851595;Dbxref=dbSNP:rs1010930015,PMID:22851595
TBK1	Q9UHD2	447	480	464	464	Natural variant	ID=VAR_041212;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:21447600;Dbxref=dbSNP:rs35635889,PMID:17344846,PMID:21447600
TBK1	Q9UHD2	689	712	696	696	Natural variant	ID=VAR_073948;Note=In FTDALS4%3B loss of kinase activity%3B impairs binding to OPTN. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25803835,ECO:0000269|PubMed:25943890;Dbxref=dbSNP:rs748112833,PMID:25803835,PMID:25943890
TBK1	Q9UHD2	29	76	30	30	Mutagenesis	Note=Decreases ubiquitination. Abolishes ubiquitination%2C phosphorylation and kinase activity%3B when associated with R-401. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453971;Dbxref=PMID:23453971
TBK1	Q9UHD2	29	76	33	33	Mutagenesis	Note=Decreases phosphorylation and kinase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453971;Dbxref=PMID:23453971
TBK1	Q9UHD2	29	76	38	38	Mutagenesis	Note=Loss of kinase activity. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10581243,ECO:0000269|PubMed:22851595,ECO:0000269|PubMed:23453971,ECO:0000269|PubMed:23453972;Dbxref=PMID:10581243,PMID:22851595,PMID:23453971,PMID:23453972
TBK1	Q9UHD2	447	480	448	448	Mutagenesis	Note=Decreases phosphorylation and kinase activity. Abolishes dimerization%3B when associated with R-355. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453972;Dbxref=PMID:23453972
TBK1	Q9UHD2	447	480	459	459	Mutagenesis	Note=Abolishes dimerization and decreases kinase activity but no effect on phosphorylation%3B when associated with E-466 and E-470. H->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453972;Dbxref=PMID:23453972
TBK1	Q9UHD2	447	480	466	466	Mutagenesis	Note=Abolishes dimerization and decreases kinase activity but no effect on phosphorylation%3B when associated with E-459 and E-470. I->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453972;Dbxref=PMID:23453972
TBK1	Q9UHD2	447	480	470	470	Mutagenesis	Note=Abolishes dimerization and decreases kinase activity but no effect on phosphorylation%3B when associated with E-459 and E-466. F->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453972;Dbxref=PMID:23453972
TBK1	Q9UHD2	689	712	690	690	Mutagenesis	Note=Decreases interaction with TANK. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21931631;Dbxref=PMID:21931631
TBK1	Q9UHD2	689	712	693	693	Mutagenesis	Note=Almost abolishes interaction with TANK. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21931631;Dbxref=PMID:21931631
TBK1	Q9UHD2	689	712	694	694	Mutagenesis	Note=Strongly decreases interaction with TANK and TBKBP1. No effect on phosphorylation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21931631;Dbxref=PMID:21931631
TBK1	Q9UHD2	689	712	704	704	Mutagenesis	Note=Strongly decreases interaction with AZI2%2C TANK and TBKBP1. No effect on phosphorylation. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21931631;Dbxref=PMID:21931631
TBK1	Q9UHD2	689	712	708	708	Mutagenesis	Note=Decreases interaction with TANK. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21931631;Dbxref=PMID:21931631
TBK1	Q9UHD2	689	712	711	711	Mutagenesis	Note=Almost abolishes interaction with TANK. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21931631;Dbxref=PMID:21931631
TBK1	Q9UHD2	29	76	29	31	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EUU
TBK1	Q9UHD2	29	76	34	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EUU
TBK1	Q9UHD2	29	76	42	46	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EUU
TBK1	Q9UHD2	29	76	49	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EUU
TBK1	Q9UHD2	29	76	65	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IWO
TBK1	Q9UHD2	29	76	70	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EUU
TBK1	Q9UHD2	447	480	408	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IM0
TBK1	Q9UHD2	689	712	680	714	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EP6
RSPO4	Q2I0M5	136	198	20	234	Chain	ID=PRO_0000234446;Note=R-spondin-4
RSPO4	Q2I0M5	89	136	20	234	Chain	ID=PRO_0000234446;Note=R-spondin-4
RSPO4	Q2I0M5	89	136	85	128	Repeat	Note=FU
RSPO4	Q2I0M5	136	198	138	197	Domain	Note=TSP type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	89	136	91	98	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	89	136	95	104	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	89	136	107	118	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	89	136	122	135	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	136	198	139	181	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	136	198	150	157	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	136	198	190	196	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO4	Q2I0M5	136	198	137	198	Alternative sequence	ID=VSP_018325;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16357527;Dbxref=PMID:16357527
RSPO4	Q2I0M5	89	136	95	95	Natural variant	ID=VAR_030400;Note=In NDNC4. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17041604;Dbxref=dbSNP:rs780506366,PMID:17041604
RSPO4	Q2I0M5	89	136	106	106	Natural variant	ID=VAR_052665;Note=R->Q;Dbxref=dbSNP:rs6140807
RSPO4	Q2I0M5	89	136	107	107	Natural variant	ID=VAR_030401;Note=In NDNC4. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17041604;Dbxref=dbSNP:rs74315421,PMID:17041604
RSPO4	Q2I0M5	89	136	118	118	Natural variant	ID=VAR_030402;Note=In NDNC4. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17041604;Dbxref=dbSNP:rs74315422,PMID:17041604
MRPS11	P82912	61	93	62	94	Alternative sequence	ID=VSP_005720;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MRPS30	Q9NP92	284	343	1	439	Chain	ID=PRO_0000087720;Note=39S ribosomal protein S30%2C mitochondrial
MRPS30	Q9NP92	284	343	283	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS30	Q9NP92	284	343	297	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS30	Q9NP92	284	343	304	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOL
MRPS30	Q9NP92	284	343	308	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS30	Q9NP92	284	343	319	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
RUNX3	Q13761	181	234	1	415	Chain	ID=PRO_0000174662;Note=Runt-related transcription factor 3
RUNX3	Q13761	146	181	1	415	Chain	ID=PRO_0000174662;Note=Runt-related transcription factor 3
RUNX3	Q13761	181	234	54	182	Domain	Note=Runt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00399
RUNX3	Q13761	146	181	54	182	Domain	Note=Runt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00399
RUNX3	Q13761	181	234	191	415	Compositional bias	Note=Pro/Ser/Thr-rich
RUNX3	Q13761	181	234	192	192	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SNRPB2	P08579	126	143	1	225	Chain	ID=PRO_0000081892;Note=U2 small nuclear ribonucleoprotein B''
SNRPB2	P08579	126	143	1	225	Chain	ID=PRO_0000081892;Note=U2 small nuclear ribonucleoprotein B''
C16orf58	Q96GQ5	410	436	2	468	Chain	ID=PRO_0000282930;Note=RUS1 family protein C16orf58
C16orf58	Q96GQ5	362	410	2	468	Chain	ID=PRO_0000282930;Note=RUS1 family protein C16orf58
C16orf58	Q96GQ5	154	164	2	468	Chain	ID=PRO_0000282930;Note=RUS1 family protein C16orf58
C16orf58	Q96GQ5	12	22	2	468	Chain	ID=PRO_0000282930;Note=RUS1 family protein C16orf58
C16orf58	Q96GQ5	154	164	1	262	Alternative sequence	ID=VSP_024255;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C16orf58	Q96GQ5	12	22	1	262	Alternative sequence	ID=VSP_024255;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBX4	P57082	94	133	1	545	Chain	ID=PRO_0000184433;Note=T-box transcription factor TBX4
TBX4	P57082	94	133	71	251	DNA binding	Note=T-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00201
WRAP53	Q9BUR4	144	176	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	423	467	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	144	176	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	423	467	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	144	176	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	423	467	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	144	176	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	423	467	1	548	Chain	ID=PRO_0000242696;Note=Telomerase Cajal body protein 1
WRAP53	Q9BUR4	144	176	167	206	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	144	176	167	206	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	144	176	167	206	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	144	176	167	206	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	423	467	411	450	Repeat	Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	423	467	411	450	Repeat	Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	423	467	411	450	Repeat	Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	423	467	411	450	Repeat	Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255
WRAP53	Q9BUR4	144	176	164	164	Natural variant	ID=VAR_065873;Note=In DKCB3%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21205863;Dbxref=dbSNP:rs281865547,PMID:21205863
WRAP53	Q9BUR4	144	176	164	164	Natural variant	ID=VAR_065873;Note=In DKCB3%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21205863;Dbxref=dbSNP:rs281865547,PMID:21205863
WRAP53	Q9BUR4	144	176	164	164	Natural variant	ID=VAR_065873;Note=In DKCB3%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21205863;Dbxref=dbSNP:rs281865547,PMID:21205863
WRAP53	Q9BUR4	144	176	164	164	Natural variant	ID=VAR_065873;Note=In DKCB3%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21205863;Dbxref=dbSNP:rs281865547,PMID:21205863
WRAP53	Q9BUR4	423	467	435	435	Natural variant	ID=VAR_065876;Note=In DKCB3%3B shortened telomeres%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21205863,ECO:0000269|PubMed:21602826;Dbxref=dbSNP:rs281865550,PMID:21205863,PMID:21602826
WRAP53	Q9BUR4	423	467	435	435	Natural variant	ID=VAR_065876;Note=In DKCB3%3B shortened telomeres%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21205863,ECO:0000269|PubMed:21602826;Dbxref=dbSNP:rs281865550,PMID:21205863,PMID:21602826
WRAP53	Q9BUR4	423	467	435	435	Natural variant	ID=VAR_065876;Note=In DKCB3%3B shortened telomeres%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21205863,ECO:0000269|PubMed:21602826;Dbxref=dbSNP:rs281865550,PMID:21205863,PMID:21602826
WRAP53	Q9BUR4	423	467	435	435	Natural variant	ID=VAR_065876;Note=In DKCB3%3B shortened telomeres%3B disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21205863,ECO:0000269|PubMed:21602826;Dbxref=dbSNP:rs281865550,PMID:21205863,PMID:21602826
TCEA2	Q15560	273	297	1	299	Chain	ID=PRO_0000121449;Note=Transcription elongation factor A protein 2
TCEA2	Q15560	273	297	257	297	Zinc finger	Note=TFIIS-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00472
CCT2	P78371	367	410	2	535	Chain	ID=PRO_0000128316;Note=T-complex protein 1 subunit beta
TPT1	P13693	133	172	1	172	Chain	ID=PRO_0000211268;Note=Translationally-controlled tumor protein
TPT1	P13693	133	172	1	172	Domain	Note=TCTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01133
TPT1	P13693	133	172	146	146	Natural variant	ID=VAR_052273;Note=V->F;Dbxref=dbSNP:rs3087989
TPT1	P13693	133	172	168	168	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
TPT1	P13693	133	172	133	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O9M
TPT1	P13693	133	172	146	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O9M
TPT1	P13693	133	172	158	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O9M
TPT1	P13693	133	172	164	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O9M
TPT1	P13693	133	172	167	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O9M
DNTTIP1	Q9H147	91	124	1	329	Chain	ID=PRO_0000072473;Note=Deoxynucleotidyltransferase terminal-interacting protein 1
DNTTIP1	Q9H147	241	265	1	329	Chain	ID=PRO_0000072473;Note=Deoxynucleotidyltransferase terminal-interacting protein 1
DNTTIP1	Q9H147	91	124	56	147	Region	Note=Important for dimerization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653165;Dbxref=PMID:25653165
DNTTIP1	Q9H147	241	265	197	316	Region	Note=Important for DNA and nucleosome binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653165;Dbxref=PMID:25653165
DNTTIP1	Q9H147	91	124	90	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D6K
DNTTIP1	Q9H147	91	124	110	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D6K
DNTTIP1	Q9H147	241	265	246	248	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MWI
DNTTIP1	Q9H147	241	265	249	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MWI
DNTTIP1	Q9H147	241	265	262	264	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MWI
TEAD2	Q15562	303	359	1	447	Chain	ID=PRO_0000205932;Note=Transcriptional enhancer factor TEF-4
TEAD2	Q15562	120	156	1	447	Chain	ID=PRO_0000205932;Note=Transcriptional enhancer factor TEF-4
TEAD2	Q15562	303	359	172	447	Region	Note=Transcriptional activation;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEAD2	Q15562	120	156	152	216	Compositional bias	Note=Pro-rich
TEAD2	Q15562	120	156	1	131	Alternative sequence	ID=VSP_045126;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TEAD2	Q15562	120	156	120	120	Alternative sequence	ID=VSP_055673;Note=In isoform 4. K->KALNV;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEAD2	Q15562	120	156	155	155	Alternative sequence	ID=VSP_045127;Note=In isoform 2 and isoform 3. P->PQVV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TEAD2	Q15562	120	156	144	144	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEAD2	Q15562	303	359	297	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L15
TEAD2	Q15562	303	359	326	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L15
TEAD2	Q15562	303	359	340	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L15
TEAD2	Q15562	303	359	352	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L15
TEKT4	Q8WW24	190	237	1	435	Chain	ID=PRO_0000261161;Note=Tektin-4
TELO2	Q9Y4R8	551	590	1	837	Chain	ID=PRO_0000318515;Note=Telomere length regulation protein TEL2 homolog
TNC	P24821	2056	2110	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1837	1885	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1797	1837	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1617	1708	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1526	1617	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1435	1526	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1344	1435	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1344	1435	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1253	1344	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1071	1162	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	1071	1162	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	801	891	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	622	710	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
TNC	P24821	622	710	625	715	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	801	891	716	804	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	801	891	805	894	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1071	1162	991	1075	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1071	1162	991	1075	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1071	1162	1076	1165	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1071	1162	1076	1165	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1253	1344	1167	1256	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1344	1435	1258	1350	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1344	1435	1258	1350	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1253	1344	1258	1350	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1435	1526	1351	1439	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1344	1435	1351	1439	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1344	1435	1351	1439	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1526	1617	1440	1531	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1435	1526	1440	1531	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1617	1708	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1526	1617	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1617	1708	1622	1711	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1797	1837	1712	1801	Domain	Note=Fibronectin type-III 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1837	1885	1802	1888	Domain	Note=Fibronectin type-III 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	1797	1837	1802	1888	Domain	Note=Fibronectin type-III 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TNC	P24821	2056	2110	1975	2190	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
TNC	P24821	1071	1162	1079	1079	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
TNC	P24821	1071	1162	1079	1079	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
TNC	P24821	1071	1162	1093	1093	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
TNC	P24821	1071	1162	1093	1093	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
TNC	P24821	1071	1162	1119	1119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1071	1162	1119	1119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1253	1344	1261	1261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
TNC	P24821	1253	1344	1275	1275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
TNC	P24821	1253	1344	1301	1301	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218;Dbxref=PMID:18780401,PMID:19159218
TNC	P24821	1344	1435	1366	1366	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
TNC	P24821	1344	1435	1366	1366	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
TNC	P24821	1344	1435	1392	1392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1344	1435	1392	1392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1435	1526	1445	1445	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1435	1526	1455	1455	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1435	1526	1485	1485	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218;Dbxref=PMID:18780401,PMID:19159218
TNC	P24821	1526	1617	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNC	P24821	1797	1837	1809	1809	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
TNC	P24821	1617	1708	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1526	1617	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1435	1526	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1344	1435	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1344	1435	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1253	1344	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1071	1162	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1071	1162	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
TNC	P24821	1617	1708	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1526	1617	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1435	1526	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1344	1435	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1344	1435	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1253	1344	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1071	1162	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1071	1162	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1435	1526	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1344	1435	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1344	1435	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1253	1344	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1071	1162	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1071	1162	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1617	1708	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	1526	1617	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
TNC	P24821	622	710	680	680	Natural variant	ID=VAR_024268;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1707164;Dbxref=dbSNP:rs1061494,PMID:1707164
TNC	P24821	801	891	850	850	Natural variant	ID=VAR_055779;Note=D->H;Dbxref=dbSNP:rs3748169
TNC	P24821	1617	1708	1677	1677	Natural variant	ID=VAR_060738;Note=I->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1704365,ECO:0000269|PubMed:1719530,ECO:0000269|PubMed:2466295,ECO:0000269|PubMed:7531707;Dbxref=dbSNP:rs2104772,PMID:1704365,PMID:1719530,PMID:2466295,PMID:7531707
TNC	P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNC	P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNC	P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNC	P24821	801	891	807	813	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNC	P24821	801	891	819	824	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNC	P24821	801	891	827	829	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RBL
TNC	P24821	801	891	831	839	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNC	P24821	801	891	842	844	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RBL
TNC	P24821	801	891	847	852	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNC	P24821	801	891	857	860	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNC	P24821	801	891	868	877	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNC	P24821	801	891	885	890	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB8
TNS1	Q9HBL0	1677	1687	1	1735	Chain	ID=PRO_0000215900;Note=Tensin-1
TNS1	Q9HBL0	1516	1547	1	1735	Chain	ID=PRO_0000215900;Note=Tensin-1
TNS1	Q9HBL0	1007	1020	1	1735	Chain	ID=PRO_0000215900;Note=Tensin-1
TNS1	Q9HBL0	351	877	1	1735	Chain	ID=PRO_0000215900;Note=Tensin-1
TNS1	Q9HBL0	312	351	1	1735	Chain	ID=PRO_0000215900;Note=Tensin-1
TNS1	Q9HBL0	73	114	1	1735	Chain	ID=PRO_0000215900;Note=Tensin-1
TNS1	Q9HBL0	73	114	4	176	Domain	Note=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
TNS1	Q9HBL0	1516	1547	1463	1572	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TNS1	Q9HBL0	351	877	651	667	Compositional bias	Note=Gln-rich
TNS1	Q9HBL0	312	351	338	338	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	364	364	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	366	366	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	378	378	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	379	379	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	433	433	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	621	621	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TNS1	Q9HBL0	351	877	701	701	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TNS1	Q9HBL0	351	877	764	764	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	769	769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	794	794	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	860	860	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TNS1	Q9HBL0	351	877	352	385	Alternative sequence	ID=VSP_056336;Note=In isoform 2. EVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNAT->DGNKQNTNSQSIGSISGGLEDQYTWPDTHWPSQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS1	Q9HBL0	1677	1687	386	1735	Alternative sequence	ID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS1	Q9HBL0	1516	1547	386	1735	Alternative sequence	ID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS1	Q9HBL0	1007	1020	386	1735	Alternative sequence	ID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS1	Q9HBL0	351	877	386	1735	Alternative sequence	ID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNS1	Q9HBL0	351	877	466	466	Natural variant	ID=VAR_047067;Note=R->C;Dbxref=dbSNP:rs3815849
TNS1	Q9HBL0	351	877	528	528	Natural variant	ID=VAR_047068;Note=T->I;Dbxref=dbSNP:rs3796033
TNS4	Q8IZW8	557	580	19	715	Chain	ID=PRO_0000248213;Note=Tensin-4
TNS4	Q8IZW8	531	557	19	715	Chain	ID=PRO_0000248213;Note=Tensin-4
TNS4	Q8IZW8	458	500	19	715	Chain	ID=PRO_0000248213;Note=Tensin-4
TNS4	Q8IZW8	531	557	449	556	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TNS4	Q8IZW8	458	500	449	556	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TNS4	Q8IZW8	557	580	548	714	Domain	Note=Phosphatase tensin-type
TNS4	Q8IZW8	531	557	548	714	Domain	Note=Phosphatase tensin-type
TNS4	Q8IZW8	557	580	570	571	Site	Note=Cleavage%3B by caspase-3
TNS4	Q8IZW8	458	500	498	498	Natural variant	ID=VAR_027265;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12154022,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2290207,PMID:12154022,PMID:14702039
TNS4	Q8IZW8	557	580	570	570	Mutagenesis	Note=Abolishes cleavage by caspase-3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15806167;Dbxref=PMID:15806167
SLC35D2	Q76EJ3	197	228	1	337	Chain	ID=PRO_0000313080;Note=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
SLC35D2	Q76EJ3	140	162	1	337	Chain	ID=PRO_0000313080;Note=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
SLC35D2	Q76EJ3	116	139	1	337	Chain	ID=PRO_0000313080;Note=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
SLC35D2	Q76EJ3	64	93	1	337	Chain	ID=PRO_0000313080;Note=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
SLC35D2	Q76EJ3	64	93	54	74	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	140	162	75	146	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	116	139	75	146	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	64	93	75	146	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	140	162	147	167	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	197	228	189	201	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	197	228	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	197	228	223	237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D2	Q76EJ3	197	228	164	251	Alternative sequence	ID=VSP_030006;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC39A5	Q6ZMH5	402	429	21	540	Chain	ID=PRO_0000045795;Note=Zinc transporter ZIP5
SLC39A5	Q6ZMH5	402	429	21	540	Chain	ID=PRO_0000045795;Note=Zinc transporter ZIP5
SLC39A5	Q6ZMH5	402	429	309	444	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A5	Q6ZMH5	402	429	309	444	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A5	Q6ZMH5	402	429	413	413	Natural variant	ID=VAR_074009;Note=In MYP24%3B unknown pathological significance. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25525168;Dbxref=PMID:25525168
SLC39A5	Q6ZMH5	402	429	413	413	Natural variant	ID=VAR_074009;Note=In MYP24%3B unknown pathological significance. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25525168;Dbxref=PMID:25525168
SLC41A2	Q96JW4	418	462	1	573	Chain	ID=PRO_0000295040;Note=Solute carrier family 41 member 2
SLC41A2	Q96JW4	418	462	407	427	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC41A2	Q96JW4	418	462	428	469	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16984228;Dbxref=PMID:16984228
SLC6A20	Q9NP91	194	231	1	592	Chain	ID=PRO_0000214812;Note=Sodium- and chloride-dependent transporter XTRP3
SLC6A20	Q9NP91	40	87	1	592	Chain	ID=PRO_0000214812;Note=Sodium- and chloride-dependent transporter XTRP3
SLC6A20	Q9NP91	40	87	27	42	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	40	87	43	63	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	40	87	64	79	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	40	87	80	100	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	194	231	187	194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	194	231	195	215	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	194	231	216	241	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A20	Q9NP91	194	231	195	231	Alternative sequence	ID=VSP_050002;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11352561,ECO:0000303|PubMed:15489334;Dbxref=PMID:11352561,PMID:15489334
SLC6A20	Q9NP91	194	231	199	199	Natural variant	ID=VAR_052068;Note=Common variant that contributes to hyperglycinuria and iminoglycinuria in patients carrying variants in SLC36A2%2C SLC6A19 or SLC6A18%3B results in SLC6A20 inactivation due to a 8-fold decrease of Vmax. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19033659;Dbxref=dbSNP:rs17279437,PMID:19033659
SLC6A20	Q9NP91	194	231	217	217	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPACA3	Q8IXA5	11	114	1	215	Chain	ID=PRO_0000256219;Note=Sperm acrosome membrane-associated protein 3%2C membrane form
SPACA3	Q8IXA5	11	114	88	215	Chain	ID=PRO_0000256220;Note=Sperm acrosome membrane-associated protein 3%2C processed form
SPACA3	Q8IXA5	11	114	1	63	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPACA3	Q8IXA5	11	114	64	84	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPACA3	Q8IXA5	11	114	85	215	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPACA3	Q8IXA5	11	114	87	88	Site	Note=Cleavage%3B to produce processed form;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPACA3	Q8IXA5	11	114	93	213	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00680
SPACA3	Q8IXA5	11	114	1	69	Alternative sequence	ID=VSP_021329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SPACA3	Q8IXA5	11	114	80	80	Natural variant	ID=VAR_028885;Note=C->Y;Dbxref=dbSNP:rs16967845
SPACA3	Q8IXA5	11	114	100	100	Natural variant	ID=VAR_028886;Note=H->R;Dbxref=dbSNP:rs28963
SLC6A13	Q9NSD5	391	437	1	602	Chain	ID=PRO_0000214792;Note=Sodium- and chloride-dependent GABA transporter 2
SLC6A13	Q9NSD5	232	277	1	602	Chain	ID=PRO_0000214792;Note=Sodium- and chloride-dependent GABA transporter 2
SLC6A13	Q9NSD5	67	112	1	602	Chain	ID=PRO_0000214792;Note=Sodium- and chloride-dependent GABA transporter 2
SLC6A13	Q9NSD5	67	112	68	88	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A13	Q9NSD5	232	277	233	253	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A13	Q9NSD5	391	437	418	438	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A13	Q9NSD5	232	277	269	269	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A13	Q9NSD5	67	112	68	159	Alternative sequence	ID=VSP_043070;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC6A13	Q9NSD5	67	112	69	97	Alternative sequence	ID=VSP_044887;Note=In isoform 3. AFFIPYLVFLFTCGIPVFLLETALGQYTS->EMRALVPPHPLLEGGYFHLLHLRPLWGVP;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SLC6A13	Q9NSD5	391	437	98	602	Alternative sequence	ID=VSP_044888;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SLC6A13	Q9NSD5	232	277	98	602	Alternative sequence	ID=VSP_044888;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SLC6A13	Q9NSD5	67	112	98	602	Alternative sequence	ID=VSP_044888;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SLC6A13	Q9NSD5	391	437	426	426	Natural variant	ID=VAR_011594;Note=V->I;Dbxref=dbSNP:rs577294
SLC6A13	Q9NSD5	391	437	429	429	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFB2M	Q9H5Q4	265	286	20	396	Chain	ID=PRO_0000273179;Note=Dimethyladenosine transferase 2%2C mitochondrial
TFB2M	Q9H5Q4	235	265	20	396	Chain	ID=PRO_0000273179;Note=Dimethyladenosine transferase 2%2C mitochondrial
TFB2M	Q9H5Q4	235	265	264	264	Natural variant	ID=VAR_030098;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19096125;Dbxref=dbSNP:rs12037377,PMID:19096125
SCG3	Q8WXD2	60	132	20	468	Chain	ID=PRO_0000005461;Note=Secretogranin-3
SCG3	Q8WXD2	328	356	20	468	Chain	ID=PRO_0000005461;Note=Secretogranin-3
SCG3	Q8WXD2	402	429	20	468	Chain	ID=PRO_0000005461;Note=Secretogranin-3
SCG3	Q8WXD2	60	132	1	232	Alternative sequence	ID=VSP_042876;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCG3	Q8WXD2	60	132	125	125	Natural variant	ID=VAR_013827;Note=S->N;Dbxref=dbSNP:rs2305710
SCG3	Q8WXD2	60	132	79	79	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCG3	Q8WXD2	402	429	421	421	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCARA3	Q6AZY7	2	35	1	606	Chain	ID=PRO_0000181633;Note=Scavenger receptor class A member 3
SCARA3	Q6AZY7	35	75	1	606	Chain	ID=PRO_0000181633;Note=Scavenger receptor class A member 3
SCARA3	Q6AZY7	108	456	1	606	Chain	ID=PRO_0000181633;Note=Scavenger receptor class A member 3
SCARA3	Q6AZY7	2	35	1	56	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	35	75	1	56	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	35	75	57	77	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	78	606	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	455	513	Domain	Note=Collagen-like 1
SCARA3	Q6AZY7	108	456	115	115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	182	182	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	224	224	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	257	257	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	313	313	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	337	337	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	365	365	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	400	400	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	430	430	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	451	451	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARA3	Q6AZY7	108	456	130	130	Natural variant	ID=VAR_025228;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34791518
SCARA3	Q6AZY7	108	456	325	325	Natural variant	ID=VAR_025229;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs33930667
SCARA3	Q6AZY7	108	456	423	423	Natural variant	ID=VAR_025230;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs3735754
SCARA3	Q6AZY7	108	456	428	428	Natural variant	ID=VAR_025231;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34086286
SCN8A	Q9UQD0	1273	1314	1	1980	Chain	ID=PRO_0000048500;Note=Sodium channel protein type 8 subunit alpha
SCN8A	Q9UQD0	1273	1314	1264	1282	Transmembrane	Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN8A	Q9UQD0	1273	1314	1283	1290	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN8A	Q9UQD0	1273	1314	1291	1309	Transmembrane	Note=Helical%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN8A	Q9UQD0	1273	1314	1310	1326	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN8A	Q9UQD0	1273	1314	1180	1495	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN8A	Q9UQD0	1273	1314	1275	1315	Alternative sequence	ID=VSP_038651;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19136557;Dbxref=PMID:19136557
SCN8A	Q9UQD0	1273	1314	1275	1283	Alternative sequence	ID=VSP_050592;Note=In isoform 4. SLVSLIANA->PLNLSGLI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9295353;Dbxref=PMID:9295353
SCN8A	Q9UQD0	1273	1314	1284	1980	Alternative sequence	ID=VSP_050593;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9295353;Dbxref=PMID:9295353
SCN8A	Q9UQD0	1273	1314	1279	1279	Natural variant	ID=VAR_078613;Note=In EIEE13. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
SCRN2	Q96FV2	0	58	1	425	Chain	ID=PRO_0000262552;Note=Secernin-2
SCRN2	Q96FV2	0	58	12	12	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCRN2	Q96FV2	0	58	52	52	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SUDS3	Q9H7L9	89	113	2	328	Chain	ID=PRO_0000097652;Note=Sin3 histone deacetylase corepressor complex component SDS3
SUDS3	Q9H7L9	89	113	2	170	Region	Note=Mediates interaction with USP17L2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21239494;Dbxref=PMID:21239494
SUDS3	Q9H7L9	89	113	66	171	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	26	70	1	27	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19838169;Dbxref=PMID:19838169
SEZ6L2	Q6UXD5	765	829	28	910	Chain	ID=PRO_0000333888;Note=Seizure 6-like protein 2
SEZ6L2	Q6UXD5	636	701	28	910	Chain	ID=PRO_0000333888;Note=Seizure 6-like protein 2
SEZ6L2	Q6UXD5	457	524	28	910	Chain	ID=PRO_0000333888;Note=Seizure 6-like protein 2
SEZ6L2	Q6UXD5	26	70	28	910	Chain	ID=PRO_0000333888;Note=Seizure 6-like protein 2
SEZ6L2	Q6UXD5	765	829	28	844	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	636	701	28	844	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	457	524	28	844	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	26	70	28	844	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	457	524	349	459	Domain	Note=CUB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
SEZ6L2	Q6UXD5	457	524	462	525	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SEZ6L2	Q6UXD5	636	701	527	638	Domain	Note=CUB 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
SEZ6L2	Q6UXD5	636	701	642	701	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SEZ6L2	Q6UXD5	765	829	703	766	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SEZ6L2	Q6UXD5	765	829	769	830	Domain	Note=Sushi 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SEZ6L2	Q6UXD5	26	70	41	48	Region	Note=O-glycosylated at one site
SEZ6L2	Q6UXD5	26	70	70	146	Compositional bias	Note=Pro-rich
SEZ6L2	Q6UXD5	457	524	473	473	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	457	524	517	517	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	636	701	641	641	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6L2	Q6UXD5	457	524	464	508	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEZ6L2	Q6UXD5	457	524	491	523	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEZ6L2	Q6UXD5	636	701	644	686	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEZ6L2	Q6UXD5	636	701	672	699	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEZ6L2	Q6UXD5	765	829	771	813	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEZ6L2	Q6UXD5	765	829	799	828	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEZ6L2	Q6UXD5	26	70	27	70	Alternative sequence	ID=VSP_044739;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEZ6L2	Q6UXD5	765	829	651	910	Alternative sequence	ID=VSP_033597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SEZ6L2	Q6UXD5	636	701	651	910	Alternative sequence	ID=VSP_033597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SEZ6L2	Q6UXD5	765	829	829	829	Alternative sequence	ID=VSP_045703;Note=In isoform 6. K->KVAYEELLDNRKLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEZ6L2	Q6UXD5	457	524	494	494	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERHL2	Q9H4I8	7	57	1	314	Chain	ID=PRO_0000097692;Note=Serine hydrolase-like protein 2
SERHL2	Q9H4I8	95	109	1	314	Chain	ID=PRO_0000097692;Note=Serine hydrolase-like protein 2
SERHL2	Q9H4I8	116	141	1	314	Chain	ID=PRO_0000097692;Note=Serine hydrolase-like protein 2
SERHL2	Q9H4I8	7	57	33	293	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERHL2	Q9H4I8	95	109	33	293	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERHL2	Q9H4I8	116	141	33	293	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERHL2	Q9H4I8	95	109	108	108	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255
SERHL2	Q9H4I8	7	57	8	57	Alternative sequence	ID=VSP_003968;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
SERHL2	Q9H4I8	7	57	12	191	Alternative sequence	ID=VSP_003970;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
SERHL2	Q9H4I8	95	109	12	191	Alternative sequence	ID=VSP_003970;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
SERHL2	Q9H4I8	116	141	12	191	Alternative sequence	ID=VSP_003970;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
SERHL2	Q9H4I8	95	109	96	109	Alternative sequence	ID=VSP_003969;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12529303;Dbxref=PMID:12529303
SERHL2	Q9H4I8	7	57	46	46	Natural variant	ID=VAR_021962;Note=S->N;Dbxref=dbSNP:rs926333
SEMA6B	Q9H3T3	534	559	26	888	Chain	ID=PRO_0000032341;Note=Semaphorin-6B
SEMA6B	Q9H3T3	534	559	26	603	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6B	Q9H3T3	534	559	526	544	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6B	Q9H3T3	534	559	532	578	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6B	Q9H3T3	534	559	536	552	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SETD1A	O15047	835	894	1	1707	Chain	ID=PRO_0000186056;Note=Histone-lysine N-methyltransferase SETD1A
SETD1A	O15047	1564	1604	1	1707	Chain	ID=PRO_0000186056;Note=Histone-lysine N-methyltransferase SETD1A
SETD1A	O15047	1564	1604	1568	1685	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SETD1B	Q9UPS6	1139	1303	1	1966	Chain	ID=PRO_0000316993;Note=Histone-lysine N-methyltransferase SETD1B
SETD1B	Q9UPS6	1779	1823	1	1966	Chain	ID=PRO_0000316993;Note=Histone-lysine N-methyltransferase SETD1B
SETD1B	Q9UPS6	1139	1303	1173	1204	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SETD1B	Q9UPS6	1139	1303	366	1671	Compositional bias	Note=Pro-rich
SETD1B	Q9UPS6	1139	1303	1040	1175	Compositional bias	Note=Ser-rich
SETD1B	Q9UPS6	1139	1303	1068	1312	Compositional bias	Note=Glu-rich
SETD1B	Q9UPS6	1139	1303	1265	1265	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFT2
SETD1B	Q9UPS6	1139	1303	1283	1283	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CFT2
SESN1	Q9Y6P5	184	265	1	492	Chain	ID=PRO_0000221178;Note=Sestrin-1
SESN1	Q9Y6P5	184	265	71	252	Region	Note=N-terminal domain%3B mediates the alkylhydroperoxide reductase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58004
SLC35D1	Q9NTN3	212	243	1	355	Chain	ID=PRO_0000213394;Note=UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
SLC35D1	Q9NTN3	155	177	1	355	Chain	ID=PRO_0000213394;Note=UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
SLC35D1	Q9NTN3	155	177	158	177	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35D1	Q9NTN3	212	243	217	239	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC41A1	Q8IVJ1	232	281	1	513	Chain	ID=PRO_0000295111;Note=Solute carrier family 41 member 1
SLC41A1	Q8IVJ1	232	281	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC41A1	Q8IVJ1	232	281	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC41A1	Q8IVJ1	232	281	272	275	Sequence conflict	Note=GISW->ASAG;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC27A1	Q6PCB7	332	402	1	646	Chain	ID=PRO_0000193201;Note=Long-chain fatty acid transport protein 1
SLC27A1	Q6PCB7	490	545	1	646	Chain	ID=PRO_0000193201;Note=Long-chain fatty acid transport protein 1
SLC27A1	Q6PCB7	545	594	1	646	Chain	ID=PRO_0000193201;Note=Long-chain fatty acid transport protein 1
SLC27A1	Q6PCB7	332	402	35	646	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60714
SLC27A1	Q6PCB7	490	545	35	646	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60714
SLC27A1	Q6PCB7	545	594	35	646	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60714
SLC27A1	Q6PCB7	332	402	191	475	Region	Note=Sufficient for oligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60714
SEC61A2	Q9H9S3	25	47	1	476	Chain	ID=PRO_0000131795;Note=Protein transport protein Sec61 subunit alpha isoform 2
SEC61A2	Q9H9S3	259	325	1	476	Chain	ID=PRO_0000131795;Note=Protein transport protein Sec61 subunit alpha isoform 2
SEC61A2	Q9H9S3	25	47	1	33	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC61A2	Q9H9S3	25	47	34	53	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC61A2	Q9H9S3	259	325	241	261	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC61A2	Q9H9S3	259	325	262	288	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC61A2	Q9H9S3	259	325	289	309	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC61A2	Q9H9S3	259	325	310	354	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC61A2	Q9H9S3	25	47	26	47	Alternative sequence	ID=VSP_046380;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC6A11	P48066	252	297	1	632	Chain	ID=PRO_0000214784;Note=Sodium- and chloride-dependent GABA transporter 3
SLC6A11	P48066	252	297	253	270	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A11	P48066	252	297	209	632	Alternative sequence	ID=VSP_056539;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC6A11	P48066	252	297	284	284	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
GM2A	P17900	27	81	24	31	Propeptide	ID=PRO_0000031639;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2209618;Dbxref=PMID:2209618
GM2A	P17900	27	81	32	193	Chain	ID=PRO_0000031640;Note=Ganglioside GM2 activator
GM2A	P17900	27	81	34	193	Chain	ID=PRO_0000031641;Note=Ganglioside GM2 activator isoform short
GM2A	P17900	27	81	63	63	Glycosylation	Note=N-linked (GlcNAc...) asparagine
GM2A	P17900	27	81	39	183	Disulfide bond	.
GM2A	P17900	27	81	59	59	Natural variant	ID=VAR_036892;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10364519,ECO:0000269|PubMed:1427911,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1915857,ECO:0000269|PubMed:2059210,ECO:0000269|PubMed:2753159;Dbxref=dbSNP:rs153477,PMID:10364519,PMID:1427911,PMID:15489334,PMID:1915857,PMID:2059210,PMID:2753159
GM2A	P17900	27	81	69	69	Natural variant	ID=VAR_036893;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10364519,ECO:0000269|PubMed:1427911,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1915857,ECO:0000269|PubMed:2059210,ECO:0000269|PubMed:2753159;Dbxref=dbSNP:rs153478,PMID:10364519,PMID:1427911,PMID:14702039,PMID:15489334,PMID:1915857,PMID:2059210,PMID:2753159
GM2A	P17900	27	81	39	39	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
GM2A	P17900	27	81	35	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AG4
GM2A	P17900	27	81	41	43	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AG4
GM2A	P17900	27	81	45	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AG4
GM2A	P17900	27	81	81	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AG4
TFF2	Q03403	76	125	24	129	Chain	ID=PRO_0000023460;Note=Trefoil factor 2
TFF2	Q03403	76	125	79	122	Domain	Note=P-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00779
TFF2	Q03403	76	125	29	127	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00779
TFF2	Q03403	76	125	81	107	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00779
TFF2	Q03403	76	125	91	106	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00779
TFF2	Q03403	76	125	101	118	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00779
TFF2	Q03403	76	125	122	122	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAR1A	Q9NR31	19	59	1	198	Chain	ID=PRO_0000206258;Note=GTP-binding protein SAR1a
SAR1A	Q9NR31	19	59	1	198	Chain	ID=PRO_0000206258;Note=GTP-binding protein SAR1a
SAR1A	Q9NR31	19	59	1	198	Chain	ID=PRO_0000206258;Note=GTP-binding protein SAR1a
SAR1A	Q9NR31	19	59	1	198	Chain	ID=PRO_0000206258;Note=GTP-binding protein SAR1a
SAR1A	Q9NR31	19	59	32	39	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1A	Q9NR31	19	59	32	39	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1A	Q9NR31	19	59	32	39	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1A	Q9NR31	19	59	32	39	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1A	Q9NR31	19	59	1	43	Alternative sequence	ID=VSP_056220;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SAR1A	Q9NR31	19	59	1	43	Alternative sequence	ID=VSP_056220;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SAR1A	Q9NR31	19	59	1	43	Alternative sequence	ID=VSP_056220;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SAR1A	Q9NR31	19	59	1	43	Alternative sequence	ID=VSP_056220;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SAR1A	Q9NR31	19	59	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	26	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	38	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	38	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	38	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SAR1A	Q9NR31	19	59	38	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GAO
SASS6	Q6UVJ0	69	103	1	657	Chain	ID=PRO_0000189972;Note=Spindle assembly abnormal protein 6 homolog
SASS6	Q6UVJ0	69	103	39	91	Domain	Note=PISA
SAT1	P21673	39	67	1	171	Chain	ID=PRO_0000074591;Note=Diamine acetyltransferase 1
SAT1	P21673	67	101	1	171	Chain	ID=PRO_0000074591;Note=Diamine acetyltransferase 1
SAT1	P21673	39	67	4	171	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
SAT1	P21673	67	101	4	171	Domain	Note=N-acetyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00532
SAT1	P21673	67	101	94	96	Region	Note=Acetyl-CoA binding;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:17516632;Dbxref=PMID:17516632
SAT1	P21673	67	101	92	92	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:17516632;Dbxref=PMID:17516632
SAT1	P21673	67	101	69	69	Sequence conflict	Note=H->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAT1	P21673	67	101	84	84	Sequence conflict	Note=W->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAT1	P21673	39	67	38	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	39	67	46	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	39	67	53	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	39	67	61	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	67	101	71	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	67	101	83	85	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	67	101	86	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
SAT1	P21673	67	101	98	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B5G
TFRC	P02786	559	633	1	760	Chain	ID=PRO_0000174132;Note=Transferrin receptor protein 1
TFRC	P02786	267	300	1	760	Chain	ID=PRO_0000174132;Note=Transferrin receptor protein 1
TFRC	P02786	229	267	1	760	Chain	ID=PRO_0000174132;Note=Transferrin receptor protein 1
TFRC	P02786	559	633	1	760	Chain	ID=PRO_0000174132;Note=Transferrin receptor protein 1
TFRC	P02786	267	300	1	760	Chain	ID=PRO_0000174132;Note=Transferrin receptor protein 1
TFRC	P02786	229	267	1	760	Chain	ID=PRO_0000174132;Note=Transferrin receptor protein 1
TFRC	P02786	559	633	101	760	Chain	ID=PRO_0000292265;Note=Transferrin receptor protein 1%2C serum form
TFRC	P02786	267	300	101	760	Chain	ID=PRO_0000292265;Note=Transferrin receptor protein 1%2C serum form
TFRC	P02786	229	267	101	760	Chain	ID=PRO_0000292265;Note=Transferrin receptor protein 1%2C serum form
TFRC	P02786	559	633	101	760	Chain	ID=PRO_0000292265;Note=Transferrin receptor protein 1%2C serum form
TFRC	P02786	267	300	101	760	Chain	ID=PRO_0000292265;Note=Transferrin receptor protein 1%2C serum form
TFRC	P02786	229	267	101	760	Chain	ID=PRO_0000292265;Note=Transferrin receptor protein 1%2C serum form
TFRC	P02786	559	633	89	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFRC	P02786	267	300	89	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFRC	P02786	229	267	89	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFRC	P02786	559	633	89	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFRC	P02786	267	300	89	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFRC	P02786	229	267	89	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFRC	P02786	267	300	223	313	Domain	Note=PA
TFRC	P02786	229	267	223	313	Domain	Note=PA
TFRC	P02786	267	300	223	313	Domain	Note=PA
TFRC	P02786	229	267	223	313	Domain	Note=PA
TFRC	P02786	559	633	569	760	Region	Note=Ligand-binding
TFRC	P02786	559	633	569	760	Region	Note=Ligand-binding
TFRC	P02786	229	267	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1CX8,ECO:0000269|PubMed:10531064,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:10531064,PMID:16335952,PMID:19159218,PMID:19349973
TFRC	P02786	229	267	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1CX8,ECO:0000269|PubMed:10531064,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:10531064,PMID:16335952,PMID:19159218,PMID:19349973
TFRC	P02786	559	633	619	619	Mutagenesis	Note=20-fold reduced affinity for transferrin receptor. No binding to HFE. L->A
TFRC	P02786	559	633	619	619	Mutagenesis	Note=20-fold reduced affinity for transferrin receptor. No binding to HFE. L->A
TFRC	P02786	559	633	622	622	Mutagenesis	Note=No significant effect on binding to transferrin nor HFE. V->A
TFRC	P02786	559	633	622	622	Mutagenesis	Note=No significant effect on binding to transferrin nor HFE. V->A
TFRC	P02786	559	633	623	623	Mutagenesis	Note=No significant effect on binding to transferrin nor HFE. R->A
TFRC	P02786	559	633	623	623	Mutagenesis	Note=No significant effect on binding to transferrin nor HFE. R->A
TFRC	P02786	559	633	629	629	Mutagenesis	Note=>5-fold reduced affinity for transferrin. >10-fold reduced affinity for HFE. R->A
TFRC	P02786	559	633	629	629	Mutagenesis	Note=>5-fold reduced affinity for transferrin. >10-fold reduced affinity for HFE. R->A
TFRC	P02786	229	267	226	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	226	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	232	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	232	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	236	238	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CX8
TFRC	P02786	229	267	236	238	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CX8
TFRC	P02786	229	267	240	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	240	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	245	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CX8
TFRC	P02786	229	267	245	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CX8
TFRC	P02786	229	267	253	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	253	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	264	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	264	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	264	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	229	267	264	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	273	275	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	273	275	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	277	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	277	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	285	287	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	267	300	285	287	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	564	567	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	564	567	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	573	579	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	573	579	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	583	603	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	583	603	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	604	606	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	604	606	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	613	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	613	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	626	628	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	626	628	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	629	636	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
TFRC	P02786	559	633	629	636	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KAS
SAV1	Q9H4B6	269	316	1	383	Chain	ID=PRO_0000076060;Note=Protein salvador homolog 1
SAV1	Q9H4B6	31	178	1	383	Chain	ID=PRO_0000076060;Note=Protein salvador homolog 1
SAV1	Q9H4B6	31	178	94	94	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAV1	Q9H4B6	31	178	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VEB2
SAV1	Q9H4B6	269	316	292	292	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAV1	Q9H4B6	269	316	298	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AO5
SAV1	Q9H4B6	269	316	306	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AO5
SAV1	Q9H4B6	269	316	316	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AO5
SLC5A9	Q2M3M2	78	113	1	681	Chain	ID=PRO_0000333805;Note=Sodium/glucose cotransporter 4
SLC5A9	Q2M3M2	78	113	76	98	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A9	Q2M3M2	78	113	99	114	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A9	Q2M3M2	78	113	113	113	Alternative sequence	ID=VSP_044577;Note=In isoform 2. N->NMRKSRSGGDRGIHPRSHGRTGVRSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC5A9	Q2M3M2	78	113	113	113	Alternative sequence	ID=VSP_057168;Note=In isoform 3. N->NMRKSRSGGDRGIHPRSHGRTG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC16A	O15027	2130	2149	1	2179	Chain	ID=PRO_0000050746;Note=Protein transport protein Sec16A
SEC16A	O15027	2053	2104	1	2179	Chain	ID=PRO_0000050746;Note=Protein transport protein Sec16A
SEC16A	O15027	1952	2025	1	2179	Chain	ID=PRO_0000050746;Note=Protein transport protein Sec16A
SEC16A	O15027	1803	1850	1	2179	Chain	ID=PRO_0000050746;Note=Protein transport protein Sec16A
SEC16A	O15027	1549	1631	1	2179	Chain	ID=PRO_0000050746;Note=Protein transport protein Sec16A
SEC16A	O15027	2130	2149	1928	2179	Region	Note=Required for interaction with SEC23A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17192411;Dbxref=PMID:17192411
SEC16A	O15027	2053	2104	1928	2179	Region	Note=Required for interaction with SEC23A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17192411;Dbxref=PMID:17192411
SEC16A	O15027	1952	2025	1928	2179	Region	Note=Required for interaction with SEC23A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17192411;Dbxref=PMID:17192411
SEC16A	O15027	2053	2104	1753	2107	Compositional bias	Note=Pro-rich
SEC16A	O15027	1952	2025	1753	2107	Compositional bias	Note=Pro-rich
SEC16A	O15027	1803	1850	1753	2107	Compositional bias	Note=Pro-rich
SEC16A	O15027	1803	1850	1844	1844	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231
SEC16A	O15027	2053	2104	2093	2093	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SEC16A	O15027	2053	2104	2053	2053	Alternative sequence	ID=VSP_036029;Note=In isoform 5. T->TPVSSVRPQGRSGRNDGLLALSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC16A	O15027	2130	2149	2087	2131	Alternative sequence	ID=VSP_015252;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC16A	O15027	2053	2104	2087	2131	Alternative sequence	ID=VSP_015252;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC16A	O15027	2053	2104	2087	2111	Alternative sequence	ID=VSP_034370;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17192411;Dbxref=PMID:17192411
SEC16A	O15027	2130	2149	2112	2131	Alternative sequence	ID=VSP_015253;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC16A	O15027	2053	2104	2101	2101	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
OXCT1	P55809	473	507	40	520	Chain	ID=PRO_0000002413;Note=Succinyl-CoA:3-ketoacid coenzyme A transferase 1%2C mitochondrial
OXCT1	P55809	446	473	40	520	Chain	ID=PRO_0000002413;Note=Succinyl-CoA:3-ketoacid coenzyme A transferase 1%2C mitochondrial
OXCT1	P55809	416	446	40	520	Chain	ID=PRO_0000002413;Note=Succinyl-CoA:3-ketoacid coenzyme A transferase 1%2C mitochondrial
OXCT1	P55809	244	280	40	520	Chain	ID=PRO_0000002413;Note=Succinyl-CoA:3-ketoacid coenzyme A transferase 1%2C mitochondrial
OXCT1	P55809	416	446	418	418	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D0K2
OXCT1	P55809	416	446	421	421	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D0K2
OXCT1	P55809	446	473	455	455	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D0K2
OXCT1	P55809	244	280	1	397	Alternative sequence	ID=VSP_056310;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
OXCT1	P55809	446	473	456	456	Natural variant	ID=VAR_000697;Note=In SCOTD. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671268;Dbxref=dbSNP:rs121909300,PMID:9671268
OXCT1	P55809	446	473	468	468	Natural variant	ID=VAR_065569;Note=In SCOTD%3B partial loss of activity%3B the mutant retains half of the activity of the wild-type at 30 degrees. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21296660;Dbxref=dbSNP:rs1327401976,PMID:21296660
OXCT1	P55809	244	280	237	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	244	280	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	244	280	263	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	244	280	268	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	416	446	416	418	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	416	446	426	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	416	446	435	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	446	473	446	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	416	446	446	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	446	473	450	455	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	446	473	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	446	473	468	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	473	507	472	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	446	473	472	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	473	507	480	482	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	473	507	483	489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	473	507	495	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	473	507	502	504	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
OXCT1	P55809	473	507	507	514	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLX
SEL1L	Q9UBV2	395	418	22	794	Chain	ID=PRO_0000022294;Note=Protein sel-1 homolog 1
SEL1L	Q9UBV2	395	418	22	738	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEL1L	Q9UBV2	395	418	373	409	Repeat	Note=Sel1-like 5
SEL1L	Q9UBV2	395	418	410	446	Repeat	Note=Sel1-like 6
SEL1L	Q9UBV2	395	418	22	737	Region	Note=Interaction with ERLEC1%2C OS9 and SYVN1
SEL1L	Q9UBV2	395	418	352	537	Region	Note=Important for homodimerization and oligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2G6
SEL1L	Q9UBV2	395	418	302	794	Alternative sequence	ID=VSP_013323;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SEH1L	Q96EE3	37	54	1	360	Chain	ID=PRO_0000051213;Note=Nucleoporin SEH1
SEH1L	Q96EE3	54	103	1	360	Chain	ID=PRO_0000051213;Note=Nucleoporin SEH1
SEH1L	Q96EE3	174	206	1	360	Chain	ID=PRO_0000051213;Note=Nucleoporin SEH1
SEH1L	Q96EE3	207	253	1	360	Chain	ID=PRO_0000051213;Note=Nucleoporin SEH1
SEH1L	Q96EE3	37	54	10	49	Repeat	Note=WD 1
SEH1L	Q96EE3	54	103	55	96	Repeat	Note=WD 2
SEH1L	Q96EE3	174	206	160	210	Repeat	Note=WD 4
SEH1L	Q96EE3	207	253	160	210	Repeat	Note=WD 4
SEH1L	Q96EE3	207	253	217	258	Repeat	Note=WD 5
SEH1L	Q96EE3	174	206	179	179	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SEH1L	Q96EE3	174	206	190	190	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SEH1L	Q96EE3	54	103	78	78	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEMA3A	Q14563	111	151	21	771	Chain	ID=PRO_0000032303;Note=Semaphorin-3A
SEMA3A	Q14563	111	151	21	771	Chain	ID=PRO_0000032303;Note=Semaphorin-3A
SEMA3A	Q14563	111	151	31	514	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA3A	Q14563	111	151	31	514	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA3A	Q14563	111	151	125	125	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA3A	Q14563	111	151	125	125	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA3A	Q14563	111	151	103	114	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEMA3A	Q14563	111	151	103	114	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEMA3A	Q14563	111	151	132	141	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEMA3A	Q14563	111	151	132	141	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEMA3A	Q14563	111	151	131	131	Natural variant	ID=VAR_036283;Note=In a breast cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs143007146,PMID:16959974
SEMA3A	Q14563	111	151	131	131	Natural variant	ID=VAR_036283;Note=In a breast cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs143007146,PMID:16959974
MRPS2	Q9Y399	14	56	1	296	Chain	ID=PRO_0000134343;Note=28S ribosomal protein S2%2C mitochondrial
MRPS2	Q9Y399	14	56	1	296	Chain	ID=PRO_0000134343;Note=28S ribosomal protein S2%2C mitochondrial
RTKN	Q9BST9	319	362	1	563	Chain	ID=PRO_0000233940;Note=Rhotekin
RTKN	Q9BST9	319	362	309	416	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
RTKN	Q9BST9	319	362	336	336	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RTKN	Q9BST9	319	362	356	356	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
RTF1	Q92541	66	103	1	710	Chain	ID=PRO_0000255936;Note=RNA polymerase-associated protein RTF1 homolog
RTF1	Q92541	606	638	1	710	Chain	ID=PRO_0000255936;Note=RNA polymerase-associated protein RTF1 homolog
RTF1	Q92541	606	638	626	626	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TBX18	O95935	166	199	1	607	Chain	ID=PRO_0000184446;Note=T-box transcription factor TBX18
TBX18	O95935	166	199	143	330	DNA binding	Note=T-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00201
RUNX2	Q13950	228	286	1	521	Chain	ID=PRO_0000174659;Note=Runt-related transcription factor 2
RUNX2	Q13950	340	362	1	521	Chain	ID=PRO_0000174659;Note=Runt-related transcription factor 2
RUNX2	Q13950	228	286	1	521	Chain	ID=PRO_0000174659;Note=Runt-related transcription factor 2
RUNX2	Q13950	340	362	1	521	Chain	ID=PRO_0000174659;Note=Runt-related transcription factor 2
RUNX2	Q13950	228	286	101	229	Domain	Note=Runt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00399
RUNX2	Q13950	228	286	101	229	Domain	Note=Runt;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00399
RUNX2	Q13950	228	286	242	258	Region	Note=Required for interaction with FOXO1;Ontology_term=ECO:0000250;evidence=ECO:0000250
RUNX2	Q13950	228	286	242	258	Region	Note=Required for interaction with FOXO1;Ontology_term=ECO:0000250;evidence=ECO:0000250
RUNX2	Q13950	340	362	336	439	Region	Note=Interaction with KAT6A;Ontology_term=ECO:0000250;evidence=ECO:0000250
RUNX2	Q13950	340	362	336	439	Region	Note=Interaction with KAT6A;Ontology_term=ECO:0000250;evidence=ECO:0000250
RUNX2	Q13950	228	286	237	521	Compositional bias	Note=Pro/Ser/Thr-rich
RUNX2	Q13950	340	362	237	521	Compositional bias	Note=Pro/Ser/Thr-rich
RUNX2	Q13950	228	286	237	521	Compositional bias	Note=Pro/Ser/Thr-rich
RUNX2	Q13950	340	362	237	521	Compositional bias	Note=Pro/Ser/Thr-rich
RUNX2	Q13950	228	286	267	267	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08775
RUNX2	Q13950	228	286	267	267	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08775
RUNX2	Q13950	228	286	238	238	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RUNX2	Q13950	228	286	238	238	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RUNX2	Q13950	340	362	341	362	Alternative sequence	ID=VSP_005938;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9233771;Dbxref=PMID:9233771
RUNX2	Q13950	340	362	341	362	Alternative sequence	ID=VSP_005938;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9233771;Dbxref=PMID:9233771
RUNX2	Q13950	228	286	67	521	Natural variant	ID=VAR_079576;Note=In CLCD%3B decreased subcellular localization in the nucleus%3B decreased transactivation activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28738062;Dbxref=PMID:28738062
RUNX2	Q13950	340	362	67	521	Natural variant	ID=VAR_079576;Note=In CLCD%3B decreased subcellular localization in the nucleus%3B decreased transactivation activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28738062;Dbxref=PMID:28738062
RUNX2	Q13950	228	286	67	521	Natural variant	ID=VAR_079576;Note=In CLCD%3B decreased subcellular localization in the nucleus%3B decreased transactivation activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28738062;Dbxref=PMID:28738062
RUNX2	Q13950	340	362	67	521	Natural variant	ID=VAR_079576;Note=In CLCD%3B decreased subcellular localization in the nucleus%3B decreased transactivation activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28738062;Dbxref=PMID:28738062
RUNX2	Q13950	228	286	228	228	Natural variant	ID=VAR_064103;Note=In CLCD. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20648631;Dbxref=PMID:20648631
RUNX2	Q13950	228	286	228	228	Natural variant	ID=VAR_064103;Note=In CLCD. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20648631;Dbxref=PMID:20648631
RUNX2	Q13950	228	286	233	233	Natural variant	ID=VAR_064104;Note=In CLCD. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20648631;Dbxref=PMID:20648631
RUNX2	Q13950	228	286	233	233	Natural variant	ID=VAR_064104;Note=In CLCD. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20648631;Dbxref=PMID:20648631
RUNX2	Q13950	340	362	362	362	Natural variant	ID=VAR_064106;Note=In CLCD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11857736;Dbxref=PMID:11857736
RUNX2	Q13950	340	362	362	362	Natural variant	ID=VAR_064106;Note=In CLCD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11857736;Dbxref=PMID:11857736
SLC13A2	Q13183	34	77	1	592	Chain	ID=PRO_0000172488;Note=Solute carrier family 13 member 2
SLC13A2	Q13183	293	365	1	592	Chain	ID=PRO_0000172488;Note=Solute carrier family 13 member 2
SLC13A2	Q13183	436	490	1	592	Chain	ID=PRO_0000172488;Note=Solute carrier family 13 member 2
SLC13A2	Q13183	490	536	1	592	Chain	ID=PRO_0000172488;Note=Solute carrier family 13 member 2
SLC13A2	Q13183	34	77	53	73	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	293	365	274	294	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	293	365	324	344	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	436	490	450	470	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	436	490	482	502	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	490	536	482	502	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	490	536	511	531	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC13A2	Q13183	34	77	1	44	Alternative sequence	ID=VSP_046426;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC13A2	Q13183	34	77	77	77	Alternative sequence	ID=VSP_046427;Note=In isoform 2 and isoform 3. E->EIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC13A2	Q13183	34	77	44	44	Natural variant	ID=VAR_029254;Note=L->F;Dbxref=dbSNP:rs45443898
SLC13A2	Q13183	34	77	45	45	Natural variant	ID=VAR_052000;Note=M->L;Dbxref=dbSNP:rs16964363
SLC13A2	Q13183	293	365	310	310	Natural variant	ID=VAR_029256;Note=A->P;Dbxref=dbSNP:rs11568441
SLC13A2	Q13183	436	490	477	477	Natural variant	ID=VAR_029257;Note=V->M;Dbxref=dbSNP:rs11568476
SLC13A2	Q13183	293	365	307	307	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC22A23	A1A5C7	515	526	1	686	Chain	ID=PRO_0000308315;Note=Solute carrier family 22 member 23
SLC22A23	A1A5C7	515	526	362	686	Alternative sequence	ID=VSP_028956;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A45	Q8N413	51	113	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
SLC25A45	Q8N413	27	51	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
SLC25A45	Q8N413	51	113	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
SLC25A45	Q8N413	27	51	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
SLC25A45	Q8N413	51	113	63	83	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A45	Q8N413	51	113	63	83	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A45	Q8N413	51	113	100	120	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A45	Q8N413	51	113	100	120	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A45	Q8N413	51	113	1	83	Repeat	Note=Solcar 1
SLC25A45	Q8N413	27	51	1	83	Repeat	Note=Solcar 1
SLC25A45	Q8N413	51	113	1	83	Repeat	Note=Solcar 1
SLC25A45	Q8N413	27	51	1	83	Repeat	Note=Solcar 1
SLC25A45	Q8N413	51	113	97	191	Repeat	Note=Solcar 2
SLC25A45	Q8N413	51	113	97	191	Repeat	Note=Solcar 2
SLC25A45	Q8N413	27	51	1	42	Alternative sequence	ID=VSP_026246;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
SLC25A45	Q8N413	27	51	1	42	Alternative sequence	ID=VSP_026246;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
SLC25A45	Q8N413	51	113	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A45	Q8N413	27	51	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A45	Q8N413	51	113	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A45	Q8N413	27	51	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A45	Q8N413	51	113	52	113	Alternative sequence	ID=VSP_026248;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SLC25A45	Q8N413	51	113	52	113	Alternative sequence	ID=VSP_026248;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SLC38A11	Q08AI6	173	227	1	406	Chain	ID=PRO_0000326059;Note=Putative sodium-coupled neutral amino acid transporter 11
SLC38A11	Q08AI6	65	87	1	406	Chain	ID=PRO_0000326059;Note=Putative sodium-coupled neutral amino acid transporter 11
SLC38A11	Q08AI6	173	227	1	406	Chain	ID=PRO_0000326059;Note=Putative sodium-coupled neutral amino acid transporter 11
SLC38A11	Q08AI6	65	87	1	406	Chain	ID=PRO_0000326059;Note=Putative sodium-coupled neutral amino acid transporter 11
SLC38A11	Q08AI6	65	87	48	68	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A11	Q08AI6	65	87	48	68	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A11	Q08AI6	173	227	156	176	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A11	Q08AI6	173	227	156	176	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A11	Q08AI6	173	227	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A11	Q08AI6	173	227	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A11	Q08AI6	65	87	66	87	Alternative sequence	ID=VSP_032529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC38A11	Q08AI6	65	87	66	87	Alternative sequence	ID=VSP_032529;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC38A11	Q08AI6	173	227	194	194	Natural variant	ID=VAR_039981;Note=A->T;Dbxref=dbSNP:rs4564790
SLC38A11	Q08AI6	173	227	194	194	Natural variant	ID=VAR_039981;Note=A->T;Dbxref=dbSNP:rs4564790
SLC26A6	Q9BXS9	533	564	1	759	Chain	ID=PRO_0000080171;Note=Solute carrier family 26 member 6
SLC26A6	Q9BXS9	378	416	1	759	Chain	ID=PRO_0000080171;Note=Solute carrier family 26 member 6
SLC26A6	Q9BXS9	195	250	1	759	Chain	ID=PRO_0000080171;Note=Solute carrier family 26 member 6
SLC26A6	Q9BXS9	195	250	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A6	Q9BXS9	195	250	208	263	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A6	Q9BXS9	378	416	369	379	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A6	Q9BXS9	378	416	380	400	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A6	Q9BXS9	378	416	401	416	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A6	Q9BXS9	533	564	506	759	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A6	Q9BXS9	533	564	530	742	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A6	Q9BXS9	195	250	145	216	Alternative sequence	ID=VSP_055273;Note=In isoform 7. GTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVR->ATPGPLPLLTAPGRPTGGAGPDPLRLRGHLPVRTSCPRLYHSCSCAGLRLTAQVCVWPPSEQPLWATVPHLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A6	Q9BXS9	195	250	217	252	Alternative sequence	ID=VSP_055274;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC26A6	Q9BXS9	195	250	206	206	Natural variant	ID=VAR_012776;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11247665;Dbxref=dbSNP:rs13324142,PMID:11247665
SH3TC1	Q8TE82	57	82	1	1336	Chain	ID=PRO_0000106355;Note=SH3 domain and tetratricopeptide repeat-containing protein 1
SH3TC1	Q8TE82	428	983	1	1336	Chain	ID=PRO_0000106355;Note=SH3 domain and tetratricopeptide repeat-containing protein 1
SH3TC1	Q8TE82	428	983	560	593	Repeat	Note=TPR 1
SH3TC1	Q8TE82	428	983	601	634	Repeat	Note=TPR 2
SH3TC1	Q8TE82	428	983	665	698	Repeat	Note=TPR 3
SH3TC1	Q8TE82	428	983	786	819	Repeat	Note=TPR 4
SH3TC1	Q8TE82	428	983	863	896	Repeat	Note=TPR 5
SH3TC1	Q8TE82	428	983	946	979	Repeat	Note=TPR 6
SH3TC1	Q8TE82	428	983	437	437	Natural variant	ID=VAR_034128;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1281145,PMID:14702039
SH3TC1	Q8TE82	428	983	719	719	Natural variant	ID=VAR_035866;Note=In a colorectal cancer sample%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs201295499,PMID:16959974
SH3TC1	Q8TE82	428	983	785	785	Natural variant	ID=VAR_021934;Note=R->C;Dbxref=dbSNP:rs1281149
SLC26A7	Q8TE54	64	101	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	159	214	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	342	380	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	496	542	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	64	101	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	159	214	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	342	380	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	496	542	1	656	Chain	ID=PRO_0000320681;Note=Anion exchange transporter
SLC26A7	Q8TE54	64	101	1	75	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	64	101	1	75	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	64	101	76	96	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	64	101	76	96	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	64	101	97	144	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	64	101	97	144	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	166	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	166	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	167	187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	167	187	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	188	202	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	188	202	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	203	223	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	159	214	203	223	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	342	380	328	343	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	342	380	328	343	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	342	380	344	364	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	342	380	344	364	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	342	380	365	383	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	342	380	365	383	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	496	542	470	656	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	496	542	470	656	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A7	Q8TE54	496	542	492	641	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A7	Q8TE54	496	542	492	641	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A7	Q8TE54	496	542	521	521	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A7	Q8TE54	496	542	521	521	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A10	Q9HBR0	648	688	1	1119	Chain	ID=PRO_0000318975;Note=Putative sodium-coupled neutral amino acid transporter 10
SLC38A10	Q9HBR0	243	304	1	1119	Chain	ID=PRO_0000318975;Note=Putative sodium-coupled neutral amino acid transporter 10
SLC38A10	Q9HBR0	119	167	1	1119	Chain	ID=PRO_0000318975;Note=Putative sodium-coupled neutral amino acid transporter 10
SLC38A10	Q9HBR0	119	167	120	140	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A10	Q9HBR0	119	167	153	173	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A10	Q9HBR0	243	304	229	249	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A10	Q9HBR0	243	304	272	292	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A2	O14975	229	282	1	620	Chain	ID=PRO_0000193204;Note=Very long-chain acyl-CoA synthetase
SLC27A2	O14975	229	282	128	261	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A2	O14975	229	282	262	282	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A2	O14975	229	282	222	233	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC27A2	O14975	229	282	230	282	Alternative sequence	ID=VSP_042726;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC6A12	P48065	510	567	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	396	442	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	510	567	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	396	442	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	510	567	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	396	442	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	510	567	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	396	442	1	614	Chain	ID=PRO_0000214788;Note=Sodium- and chloride-dependent betaine transporter
SLC6A12	P48065	396	442	423	441	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	396	442	423	441	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	396	442	423	441	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	396	442	423	441	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	499	518	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	499	518	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	499	518	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	499	518	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	538	556	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	538	556	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	538	556	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	538	556	Transmembrane	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	557	614	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	557	614	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	557	614	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A12	P48065	510	567	557	614	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SACS	Q9NZJ4	152	201	1	4579	Chain	ID=PRO_0000097563;Note=Sacsin
SACS	Q9NZJ4	152	201	1	750	Alternative sequence	ID=VSP_022325;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SACS	Q9NZJ4	152	201	168	168	Natural variant	ID=VAR_064801;Note=In SACS. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18465152;Dbxref=PMID:18465152
SACS	Q9NZJ4	152	201	201	201	Natural variant	ID=VAR_064802;Note=In SACS. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20876471;Dbxref=PMID:20876471
SACS	Q9NZJ4	152	201	155	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V44
SACS	Q9NZJ4	152	201	166	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V44
SACS	Q9NZJ4	152	201	175	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V46
SACS	Q9NZJ4	152	201	193	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V44
TFAP4	Q01664	222	274	1	338	Chain	ID=PRO_0000127458;Note=Transcription factor AP-4
TFAP4	Q01664	85	118	1	338	Chain	ID=PRO_0000127458;Note=Transcription factor AP-4
TFAP4	Q01664	85	118	48	99	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
TFAP4	Q01664	85	118	100	120	Region	Note=Leucine-zipper 1
TFAP4	Q01664	222	274	193	222	Compositional bias	Note=Gln-rich
TFAP4	Q01664	222	274	225	244	Compositional bias	Note=Pro-rich
TFCP2	Q12800	188	239	1	502	Chain	ID=PRO_0000228001;Note=Alpha-globin transcription factor CP2
TFCP2	Q12800	188	239	133	395	Region	Note=DNA-binding
TFCP2	Q12800	188	239	189	239	Alternative sequence	ID=VSP_017647;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8035790,ECO:0000303|PubMed:8114710;Dbxref=PMID:8035790,PMID:8114710
TFCP2	Q12800	188	239	211	211	Mutagenesis	Note=Does not affect DNA-binding activity. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8035790;Dbxref=PMID:8035790
TFCP2	Q12800	188	239	213	213	Mutagenesis	Note=Does not affect DNA-binding activity. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8035790;Dbxref=PMID:8035790
TFCP2	Q12800	188	239	234	234	Mutagenesis	Note=Significant reduction of DNA-binding activity. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8035790;Dbxref=PMID:8035790
TFCP2	Q12800	188	239	236	236	Mutagenesis	Note=Significant reduction of DNA-binding activity. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8035790;Dbxref=PMID:8035790
SAP18	O00422	61	101	2	153	Chain	ID=PRO_0000220975;Note=Histone deacetylase complex subunit SAP18
SAP18	O00422	61	101	93	153	Region	Note=Involved in splicing regulation activity
SAP18	O00422	61	101	66	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDE
SAP18	O00422	61	101	78	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDE
SAP18	O00422	61	101	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDE
SAP18	O00422	61	101	95	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDE
SATB2	Q9UPW6	56	115	1	733	Chain	ID=PRO_0000202400;Note=DNA-binding protein SATB2
SATB2	Q9UPW6	56	115	1	733	Chain	ID=PRO_0000202400;Note=DNA-binding protein SATB2
SATB2	Q9UPW6	56	115	1	733	Chain	ID=PRO_0000202400;Note=DNA-binding protein SATB2
SLC1A4	P43007	190	211	1	532	Chain	ID=PRO_0000202079;Note=Neutral amino acid transporter A
SLC1A4	P43007	267	344	1	532	Chain	ID=PRO_0000202079;Note=Neutral amino acid transporter A
SLC1A4	P43007	410	454	1	532	Chain	ID=PRO_0000202079;Note=Neutral amino acid transporter A
SLC1A4	P43007	190	211	140	216	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A4	P43007	267	344	257	277	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A4	P43007	267	344	298	318	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A4	P43007	267	344	328	348	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A4	P43007	410	454	418	438	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC1A4	P43007	190	211	201	201	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
SLC1A4	P43007	190	211	206	206	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
SLC1A4	P43007	190	211	1	220	Alternative sequence	ID=VSP_042880;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC1A4	P43007	267	344	267	345	Alternative sequence	ID=VSP_042881;Note=In isoform 2. WYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSS->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SBSN	Q6UWP8	568	583	26	590	Chain	ID=PRO_0000317120;Note=Suprabasin
SEC22C	Q9BRL7	215	237	1	303	Chain	ID=PRO_0000324161;Note=Vesicle-trafficking protein SEC22c
SEC22C	Q9BRL7	215	237	205	223	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC22C	Q9BRL7	215	237	224	244	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC22C	Q9BRL7	215	237	216	228	Alternative sequence	ID=VSP_032161;Note=In isoform 3. VAHEEIGNILAFL->DPRSWFCWLDQTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SEC22C	Q9BRL7	215	237	229	303	Alternative sequence	ID=VSP_032162;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SEC11C	Q9BY50	66	115	1	192	Chain	ID=PRO_0000109548;Note=Signal peptidase complex catalytic subunit SEC11C
SEC11C	Q9BY50	116	155	1	192	Chain	ID=PRO_0000109548;Note=Signal peptidase complex catalytic subunit SEC11C
SEC11C	Q9BY50	66	115	49	192	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC11C	Q9BY50	116	155	49	192	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC11C	Q9BY50	66	115	68	68	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC5A1	P13866	69	104	1	664	Chain	ID=PRO_0000105366;Note=Sodium/glucose cotransporter 1
SLC5A1	P13866	340	376	1	664	Chain	ID=PRO_0000105366;Note=Sodium/glucose cotransporter 1
SLC5A1	P13866	69	104	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A1	P13866	69	104	86	105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A1	P13866	340	376	335	380	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A1	P13866	340	376	255	610	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC5A1	P13866	69	104	1	127	Alternative sequence	ID=VSP_044782;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC5A10	A0PJK1	116	151	1	596	Chain	ID=PRO_0000311211;Note=Sodium/glucose cotransporter 5
SLC5A10	A0PJK1	186	213	1	596	Chain	ID=PRO_0000311211;Note=Sodium/glucose cotransporter 5
SLC5A10	A0PJK1	327	363	1	596	Chain	ID=PRO_0000311211;Note=Sodium/glucose cotransporter 5
SLC5A10	A0PJK1	116	151	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	116	151	121	149	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	116	151	150	170	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	186	213	174	194	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	186	213	195	200	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	186	213	201	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	327	363	322	355	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	327	363	356	376	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A10	A0PJK1	116	151	141	141	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SLC5A10	A0PJK1	116	151	145	145	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SLC5A10	A0PJK1	116	151	148	148	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SLC5A10	A0PJK1	186	213	187	213	Alternative sequence	ID=VSP_029417;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC5A10	A0PJK1	327	363	327	327	Alternative sequence	ID=VSP_029418;Note=In isoform 3 and isoform 4. P->PGAHVYEERHQVSVSRT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SLC5A10	A0PJK1	327	363	328	363	Alternative sequence	ID=VSP_045061;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC5A11	Q8WWX8	69	104	1	675	Chain	ID=PRO_0000331568;Note=Sodium/myo-inositol cotransporter 2
SLC5A11	Q8WWX8	124	159	1	675	Chain	ID=PRO_0000331568;Note=Sodium/myo-inositol cotransporter 2
SLC5A11	Q8WWX8	194	221	1	675	Chain	ID=PRO_0000331568;Note=Sodium/myo-inositol cotransporter 2
SLC5A11	Q8WWX8	69	104	66	88	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	69	104	89	102	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	69	104	103	123	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	124	159	124	135	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	124	159	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	124	159	157	180	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	194	221	181	201	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	194	221	202	208	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	194	221	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A11	Q8WWX8	69	104	70	104	Alternative sequence	ID=VSP_045034;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC5A11	Q8WWX8	124	159	125	159	Alternative sequence	ID=VSP_052790;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12039040,ECO:0000303|PubMed:14702039;Dbxref=PMID:12039040,PMID:14702039
SEC24A	O95486	188	246	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	246	272	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	593	662	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	702	755	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	755	813	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	813	850	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	909	955	1	1093	Chain	ID=PRO_0000205153;Note=Protein transport protein Sec24A
SEC24A	O95486	188	246	89	237	Compositional bias	Note=Pro-rich
SEC24A	O95486	593	662	594	613	Alternative sequence	ID=VSP_029571;Note=In isoform 2. LVQDLLKTLPQMFTKTLETQ->SVIGVSSEETLITCLEIAMR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24A	O95486	593	662	614	1093	Alternative sequence	ID=VSP_029572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24A	O95486	702	755	614	1093	Alternative sequence	ID=VSP_029572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24A	O95486	755	813	614	1093	Alternative sequence	ID=VSP_029572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24A	O95486	813	850	614	1093	Alternative sequence	ID=VSP_029572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24A	O95486	909	955	614	1093	Alternative sequence	ID=VSP_029572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24A	O95486	246	272	261	261	Natural variant	ID=VAR_037253;Note=S->G;Dbxref=dbSNP:rs7718102
SEC24A	O95486	593	662	592	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	593	662	602	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	593	662	605	608	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	593	662	616	627	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	593	662	628	630	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	593	662	632	638	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	593	662	657	659	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUP
SEC24A	O95486	702	755	699	702	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	702	755	704	707	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	702	755	708	710	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	702	755	713	715	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	702	755	721	723	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	702	755	725	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	702	755	744	753	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	755	813	757	768	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	755	813	770	772	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VNL
SEC24A	O95486	755	813	774	779	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	755	813	785	793	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	755	813	799	810	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	813	850	816	828	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	813	850	831	836	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	813	850	840	857	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	909	955	910	912	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	909	955	920	932	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	909	955	935	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	909	955	945	948	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC24A	O95486	909	955	954	956	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC16B	Q96JE7	857	908	1	1060	Chain	ID=PRO_0000341974;Note=Protein transport protein Sec16B
SEC16B	Q96JE7	857	908	858	858	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SEC16B	Q96JE7	857	908	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q75N33
SEC16B	Q96JE7	857	908	871	871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91XT4
SEC16B	Q96JE7	857	908	874	874	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91XT4
SEC16B	Q96JE7	857	908	882	882	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91XT4
SEC16B	Q96JE7	857	908	883	883	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91XT4
SEC16B	Q96JE7	857	908	625	1060	Alternative sequence	ID=VSP_034374;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC16B	Q96JE7	857	908	864	864	Natural variant	ID=VAR_044133;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs591120,PMID:17974005
SEC16B	Q96JE7	857	908	873	873	Natural variant	ID=VAR_044134;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs3813649,PMID:17974005
SEC24B	O95487	44	292	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	292	353	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	353	388	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	388	415	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	767	836	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	988	1025	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	1084	1130	2	1268	Chain	ID=PRO_0000205155;Note=Protein transport protein Sec24B
SEC24B	O95487	353	388	379	387	Compositional bias	Note=Poly-Glu
SEC24B	O95487	292	353	329	329	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SEC24B	O95487	44	292	44	44	Alternative sequence	ID=VSP_054432;Note=In isoform 3. N->NETGFHHVAQASLELLDPSNLPASASQIAGST;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24B	O95487	353	388	354	388	Alternative sequence	ID=VSP_035987;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24B	O95487	388	415	354	388	Alternative sequence	ID=VSP_035987;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC24B	O95487	767	836	766	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	767	836	776	778	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	767	836	790	801	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	767	836	802	804	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	767	836	806	812	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	767	836	831	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	767	836	835	837	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	988	1025	991	1003	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	988	1025	1006	1011	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	988	1025	1015	1032	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	1084	1130	1085	1087	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	1084	1130	1095	1107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	1084	1130	1110	1117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
SEC24B	O95487	1084	1130	1120	1123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH1
RAPGEF3	O95398	559	608	1	923	Chain	ID=PRO_0000068867;Note=Rap guanine nucleotide exchange factor 3
RAPGEF3	O95398	73	91	1	923	Chain	ID=PRO_0000068867;Note=Rap guanine nucleotide exchange factor 3
RAPGEF3	O95398	559	608	1	923	Chain	ID=PRO_0000068867;Note=Rap guanine nucleotide exchange factor 3
RAPGEF3	O95398	73	91	1	923	Chain	ID=PRO_0000068867;Note=Rap guanine nucleotide exchange factor 3
RAPGEF3	O95398	73	91	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCC8
RAPGEF3	O95398	73	91	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCC8
RAPGEF3	O95398	559	608	533	598	Alternative sequence	ID=VSP_007608;Note=In isoform 2. ARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKG->VSAWPQFLSSAPPGLQAPPSPPDPEGLCGRGKLSSHRHTLGSLIGVHGALAACGALGQAVPGGAEA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9856955;Dbxref=PMID:9856955
RAPGEF3	O95398	559	608	533	598	Alternative sequence	ID=VSP_007608;Note=In isoform 2. ARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKG->VSAWPQFLSSAPPGLQAPPSPPDPEGLCGRGKLSSHRHTLGSLIGVHGALAACGALGQAVPGGAEA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9856955;Dbxref=PMID:9856955
RAPGEF3	O95398	559	608	599	923	Alternative sequence	ID=VSP_007609;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9856955;Dbxref=PMID:9856955
RAPGEF3	O95398	559	608	599	923	Alternative sequence	ID=VSP_007609;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9856955;Dbxref=PMID:9856955
RSPH1	Q8WYR4	167	191	1	309	Chain	ID=PRO_0000065662;Note=Radial spoke head 1 homolog
RSPH1	Q8WYR4	18	56	1	309	Chain	ID=PRO_0000065662;Note=Radial spoke head 1 homolog
RSPH1	Q8WYR4	18	56	20	43	Repeat	Note=MORN 1
RSPH1	Q8WYR4	18	56	44	66	Repeat	Note=MORN 2
RSPH1	Q8WYR4	167	191	159	181	Repeat	Note=MORN 6
RSPH1	Q8WYR4	18	56	19	56	Alternative sequence	ID=VSP_055743;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPS23	Q9Y3D9	72	97	2	190	Chain	ID=PRO_0000087705;Note=28S ribosomal protein S23%2C mitochondrial
VCP	P55072	668	720	2	806	Chain	ID=PRO_0000084572;Note=Transitional endoplasmic reticulum ATPase
VCP	P55072	494	565	2	806	Chain	ID=PRO_0000084572;Note=Transitional endoplasmic reticulum ATPase
VCP	P55072	453	494	2	806	Chain	ID=PRO_0000084572;Note=Transitional endoplasmic reticulum ATPase
VCP	P55072	192	236	2	806	Chain	ID=PRO_0000084572;Note=Transitional endoplasmic reticulum ATPase
VCP	P55072	494	565	521	526	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01853
VCP	P55072	453	494	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VCP	P55072	494	565	502	502	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01853
VCP	P55072	494	565	505	505	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01853
VCP	P55072	668	720	668	668	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01853
VCP	P55072	668	720	668	668	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01853
VCP	P55072	668	720	702	702	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VCP	P55072	192	236	198	198	Natural variant	ID=VAR_076468;Note=In IBMPFD1%3B increased ATPase activity%3B impaired autophagic function. L->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17935506,ECO:0000269|PubMed:20335036,ECO:0000269|PubMed:25878907,ECO:0000269|PubMed:27753622;Dbxref=PMID:17935506,PMID:20335036,PMID:25878907,PMID:27753622
VCP	P55072	192	236	232	232	Natural variant	ID=VAR_033022;Note=In IBMPFD1%3B increased ATPase activity%3B no defect in ubiquitin-dependent protein degradation by the proteasome%3B impaired autophagic function%3B defect in maturation of ubiquitin-containing autophagosomes%3B decreased interaction with CAV1 and UBXN6. A->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15034582,ECO:0000269|PubMed:20104022,ECO:0000269|PubMed:21822278,ECO:0000269|PubMed:25125609,ECO:0000269|PubMed:25878907,ECO:0000269|PubMed:27753622;Dbxref=dbSNP:rs121909331,PMID:15034582,PMID:20104022,PMID:21822278,PMID:25125609,PMID:25878907,PMID:27753622
VCP	P55072	494	565	524	524	Mutagenesis	Note=Impairs catalytic activity of RNF19A toward SOD1 mutant. Does not inhibit interaction with RHBDD1%3B when associated with A-251. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15456787,ECO:0000269|PubMed:16168377,ECO:0000269|PubMed:22795130;Dbxref=PMID:15456787,PMID:16168377,PMID:22795130
VCP	P55072	494	565	524	524	Mutagenesis	Note=Impairs ERAD degradation of HMGCR%3B when associated with Q-251. K->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15456787,ECO:0000269|PubMed:16168377,ECO:0000269|PubMed:22795130;Dbxref=PMID:15456787,PMID:16168377,PMID:22795130
VCP	P55072	192	236	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KDL
VCP	P55072	192	236	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	192	236	203	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	192	236	210	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	192	236	221	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	192	236	227	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	453	494	449	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	453	494	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	453	494	462	468	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KO8
VCP	P55072	453	494	476	478	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTK
VCP	P55072	494	565	483	498	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	453	494	483	498	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	494	565	500	505	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	494	565	513	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	494	565	524	534	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	494	565	538	542	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	494	565	544	552	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	494	565	559	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	668	720	672	678	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
VCP	P55072	668	720	684	706	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTJ
SLC18B1	Q6NT16	362	386	1	456	Chain	ID=PRO_0000294450;Note=MFS-type transporter SLC18B1
SLC18B1	Q6NT16	330	361	1	456	Chain	ID=PRO_0000294450;Note=MFS-type transporter SLC18B1
SLC18B1	Q6NT16	265	299	1	456	Chain	ID=PRO_0000294450;Note=MFS-type transporter SLC18B1
SLC18B1	Q6NT16	265	299	252	272	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	265	299	273	293	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	265	299	294	304	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	330	361	326	331	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	330	361	332	352	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	362	386	353	377	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	330	361	353	377	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18B1	Q6NT16	362	386	378	398	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A3	Q8IY34	478	530	1	581	Chain	ID=PRO_0000295912;Note=Solute carrier family 15 member 3
SLC15A3	Q8IY34	332	369	1	581	Chain	ID=PRO_0000295912;Note=Solute carrier family 15 member 3
SLC15A3	Q8IY34	332	369	369	389	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A3	Q8IY34	478	530	458	478	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A3	Q8IY34	478	530	497	517	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A3	Q8IY34	332	369	356	356	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A3	Q8IY34	332	369	349	349	Natural variant	ID=VAR_034592;Note=I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855607,PMID:15489334
SLC15A4	Q8N697	471	524	1	577	Chain	ID=PRO_0000338599;Note=Solute carrier family 15 member 4
SLC15A4	Q8N697	471	524	459	479	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A4	Q8N697	471	524	490	510	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A9	Q9BYT1	372	382	1	436	Chain	ID=PRO_0000084849;Note=Solute carrier family 17 member 9
SLC17A9	Q9BYT1	372	382	369	389	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A9	Q9BYT1	372	382	217	436	Alternative sequence	ID=VSP_010346;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
SLC26A10	Q8NG04	185	236	1	563	Chain	ID=PRO_0000344230;Note=Solute carrier family 26 member 10
SLC26A10	Q8NG04	377	409	1	563	Chain	ID=PRO_0000344230;Note=Solute carrier family 26 member 10
SLC26A10	Q8NG04	377	409	406	541	Domain	Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198
SLC26A10	Q8NG04	185	236	193	193	Natural variant	ID=VAR_045600;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs923828,PMID:14702039
SLC25A43	Q8WUT9	230	275	1	341	Chain	ID=PRO_0000291823;Note=Solute carrier family 25 member 43
SLC25A43	Q8WUT9	230	275	262	282	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A43	Q8WUT9	230	275	200	298	Repeat	Note=Solcar 3
SLC28A3	Q9HAS3	576	609	1	691	Chain	ID=PRO_0000324146;Note=Solute carrier family 28 member 3
SLC28A3	Q9HAS3	261	287	1	691	Chain	ID=PRO_0000324146;Note=Solute carrier family 28 member 3
SLC28A3	Q9HAS3	261	287	245	287	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A3	Q9HAS3	576	609	575	593	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A3	Q9HAS3	576	609	594	614	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC28A3	Q9HAS3	576	609	585	585	Natural variant	ID=VAR_039677;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15738947;Dbxref=dbSNP:rs11568398,PMID:15738947
SLC28A3	Q9HAS3	576	609	602	602	Natural variant	ID=VAR_039678;Note=Lower concentrative capacity and altered sodium binding capacity. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17993510;Dbxref=PMID:17993510
SLC35E1	Q96K37	164	210	1	410	Chain	ID=PRO_0000071941;Note=Solute carrier family 35 member E1
SLC35E1	Q96K37	164	210	165	184	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35E1	Q96K37	164	210	188	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35E1	Q96K37	164	210	1	300	Alternative sequence	ID=VSP_010139;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TEX9	Q8N6V9	276	321	1	391	Chain	ID=PRO_0000244481;Note=Testis-expressed protein 9
TEX9	Q8N6V9	321	366	1	391	Chain	ID=PRO_0000244481;Note=Testis-expressed protein 9
TEX9	Q8N6V9	276	321	188	351	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TEX9	Q8N6V9	321	366	188	351	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A3	Q9Y2D2	114	155	1	325	Chain	ID=PRO_0000213357;Note=UDP-N-acetylglucosamine transporter
SLC35A3	Q9Y2D2	114	155	1	325	Chain	ID=PRO_0000213357;Note=UDP-N-acetylglucosamine transporter
SLC35A3	Q9Y2D2	114	155	138	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35A3	Q9Y2D2	114	155	138	154	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A14	Q15043	209	250	31	492	Chain	ID=PRO_0000312194;Note=Zinc transporter ZIP14
SLC39A14	Q15043	209	250	31	492	Chain	ID=PRO_0000312194;Note=Zinc transporter ZIP14
SLC39A14	Q15043	209	250	208	224	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A14	Q15043	209	250	208	224	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A14	Q15043	209	250	225	245	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A14	Q15043	209	250	225	245	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A14	Q15043	209	250	246	397	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC39A14	Q15043	209	250	246	397	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	477	506	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	317	353	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	252	317	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	175	232	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	477	506	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	317	353	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	252	317	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	175	232	1	561	Chain	ID=PRO_0000328840;Note=Sodium-coupled neutral amino acid transporter 9
SLC38A9	Q8NBW4	175	232	166	198	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	175	232	166	198	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	175	232	199	219	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	175	232	199	219	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	252	317	220	290	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	175	232	220	290	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	252	317	220	290	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	175	232	220	290	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	252	317	291	311	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	252	317	291	311	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	252	317	312	313	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	252	317	312	313	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	317	353	314	334	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	252	317	314	334	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	317	353	314	334	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	252	317	314	334	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	317	353	335	358	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	317	353	335	358	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	477	506	462	477	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	477	506	462	477	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	477	506	478	498	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	477	506	478	498	Transmembrane	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A9	Q8NBW4	477	506	499	509	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	477	506	499	509	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC38A9	Q8NBW4	252	317	266	266	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
SLC38A9	Q8NBW4	252	317	266	266	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
SLC38A9	Q8NBW4	252	317	274	274	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
SLC38A9	Q8NBW4	252	317	274	274	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
SLC38A9	Q8NBW4	317	353	318	353	Alternative sequence	ID=VSP_045112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC38A9	Q8NBW4	317	353	318	353	Alternative sequence	ID=VSP_045112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLC38A9	Q8NBW4	477	506	428	561	Alternative sequence	ID=VSP_032815;Note=In isoform 2. NFLDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLIFHVFIIILGVANLIVQFFM->VRHRVPSLCDCVHFHVFIVGRVIQWQDITSDRPGF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC38A9	Q8NBW4	477	506	428	561	Alternative sequence	ID=VSP_032815;Note=In isoform 2. NFLDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLIFHVFIIILGVANLIVQFFM->VRHRVPSLCDCVHFHVFIVGRVIQWQDITSDRPGF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC38A9	Q8NBW4	175	232	182	182	Natural variant	ID=VAR_042546;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs4865615,PMID:14702039,PMID:15489334,PMID:17974005
SLC38A9	Q8NBW4	175	232	182	182	Natural variant	ID=VAR_042546;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs4865615,PMID:14702039,PMID:15489334,PMID:17974005
SLC4A5	Q9BY07	773	811	1	1137	Chain	ID=PRO_0000328920;Note=Electrogenic sodium bicarbonate cotransporter 4
SLC4A5	Q9BY07	26	90	1	1137	Chain	ID=PRO_0000328920;Note=Electrogenic sodium bicarbonate cotransporter 4
SLC4A5	Q9BY07	972	988	1	1137	Chain	ID=PRO_0000328920;Note=Electrogenic sodium bicarbonate cotransporter 4
SLC4A5	Q9BY07	773	811	1	1137	Chain	ID=PRO_0000328920;Note=Electrogenic sodium bicarbonate cotransporter 4
SLC4A5	Q9BY07	26	90	1	1137	Chain	ID=PRO_0000328920;Note=Electrogenic sodium bicarbonate cotransporter 4
SLC4A5	Q9BY07	26	90	1	521	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	26	90	1	521	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	773	811	763	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	773	811	763	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	773	811	774	795	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	773	811	774	795	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	773	811	796	828	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	773	811	796	828	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	972	988	972	1016	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A5	Q9BY07	26	90	27	91	Alternative sequence	ID=VSP_052770;Note=In isoform 7. ECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC4A5	Q9BY07	26	90	27	91	Alternative sequence	ID=VSP_052770;Note=In isoform 7. ECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC4A5	Q9BY07	26	90	88	91	Alternative sequence	ID=VSP_052771;Note=In isoform 5. SRTR->EHKG;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
SLC4A5	Q9BY07	26	90	88	91	Alternative sequence	ID=VSP_052771;Note=In isoform 5. SRTR->EHKG;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
SLC4A5	Q9BY07	773	811	774	811	Alternative sequence	ID=VSP_052772;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12388414,ECO:0000303|PubMed:15489334;Dbxref=PMID:12388414,PMID:15489334
SLC4A5	Q9BY07	773	811	774	811	Alternative sequence	ID=VSP_052772;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12388414,ECO:0000303|PubMed:15489334;Dbxref=PMID:12388414,PMID:15489334
SLC4A5	Q9BY07	972	988	866	993	Alternative sequence	ID=VSP_052773;Note=In isoform 5. KAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERC->GTESNRHHRLHPDGNLCLPGSHPKVYPPAGAVRSLPLHGRGLPEWHPVLGTLQALPDASQAPAGPCLPAARAAAPDPPLHPGADPLPGGALDPQIHGGCHHLPGHDPGPHHRSKASGFHLFPARPGLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
SLC4A5	Q9BY07	972	988	950	1046	Alternative sequence	ID=VSP_052775;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12063394;Dbxref=PMID:12063394
SLC4A5	Q9BY07	972	988	973	988	Alternative sequence	ID=VSP_052776;Note=In isoform 3%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11788353,ECO:0000303|PubMed:11997242,ECO:0000303|PubMed:12388414,ECO:0000303|PubMed:15489334;Dbxref=PMID:11788353,PMID:11997242,PMID:12388414,PMID:15489334
SLC27A4	Q6P1M0	185	238	1	643	Chain	ID=PRO_0000193209;Note=Long-chain fatty acid transport protein 4
SLC27A4	Q6P1M0	329	399	1	643	Chain	ID=PRO_0000193209;Note=Long-chain fatty acid transport protein 4
SLC27A4	Q6P1M0	542	591	1	643	Chain	ID=PRO_0000193209;Note=Long-chain fatty acid transport protein 4
SLC27A4	Q6P1M0	185	238	77	482	Alternative sequence	ID=VSP_055809;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC27A4	Q6P1M0	329	399	77	482	Alternative sequence	ID=VSP_055809;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC27A4	Q6P1M0	185	238	209	209	Natural variant	ID=VAR_023783;Note=Correlates with lower body mass index%2C triglyceride concentrations%2C systolic blood pressure%2C insulin concentrations and homeostasis model assessment index. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14715877;Dbxref=dbSNP:rs2240953,PMID:14715877
SLC27A4	Q6P1M0	329	399	374	374	Natural variant	ID=VAR_064500;Note=In IPS. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20815031;Dbxref=dbSNP:rs768495407,PMID:20815031
SLC27A4	Q6P1M0	542	591	583	583	Natural variant	ID=VAR_063195;Note=In IPS. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19631310;Dbxref=dbSNP:rs137853135,PMID:19631310
SLC27A4	Q6P1M0	185	238	194	194	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCML4	Q8N228	227	324	1	414	Chain	ID=PRO_0000337171;Note=Sex comb on midleg-like protein 4
SCML4	Q8N228	95	162	1	414	Chain	ID=PRO_0000337171;Note=Sex comb on midleg-like protein 4
SCML4	Q8N228	227	324	288	354	Domain	Note=SAM
SCML4	Q8N228	95	162	126	126	Natural variant	ID=VAR_043669;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs6934505,PMID:14702039
SCNM1	Q9BWG6	133	197	1	230	Chain	ID=PRO_0000259635;Note=Sodium channel modifier 1
SCNM1	Q9BWG6	133	197	188	230	Region	Note=Required for interaction with LUC7L2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SCNM1	Q9BWG6	133	197	144	144	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SCNM1	Q9BWG6	133	197	183	183	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K136
SCNM1	Q9BWG6	133	197	134	162	Alternative sequence	ID=VSP_053982;Note=In isoform 3. PEAPGPSVSLSPMPPSEVKLQSGKISREP->YGTGKPEVGRLRRRQMALKEFSSVYSEEY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCNM1	Q9BWG6	133	197	163	230	Alternative sequence	ID=VSP_053983;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCTR	P47872	64	100	23	440	Chain	ID=PRO_0000012852;Note=Secretin receptor
SCTR	P47872	64	100	23	143	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCTR	P47872	64	100	72	72	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCTR	P47872	64	100	100	100	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE1	Q8IWY4	740	794	24	988	Chain	ID=PRO_0000254648;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 1
SCUBE1	Q8IWY4	116	161	24	988	Chain	ID=PRO_0000254648;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 1
SCUBE1	Q8IWY4	116	161	74	116	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE1	Q8IWY4	116	161	117	153	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE1	Q8IWY4	740	794	750	750	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE1	Q8IWY4	740	794	779	779	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE1	Q8IWY4	740	794	789	789	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE1	Q8IWY4	116	161	121	132	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE1	Q8IWY4	116	161	128	141	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	805	871	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	638	695	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	517	569	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	482	517	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	443	482	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	402	443	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	363	402	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	253	283	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	85	127	32	999	Chain	ID=PRO_0000255580;Note=Signal peptide%2C CUB and EGF-like domain-containing protein 2
SCUBE2	Q9NQ36	85	127	45	85	Domain	Note=EGF-like 1%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	85	127	86	127	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	363	402	323	363	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	402	443	364	402	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	363	402	364	402	Domain	Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	443	482	403	443	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	402	443	403	443	Domain	Note=EGF-like 9%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SCUBE2	Q9NQ36	805	871	809	921	Domain	Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
SCUBE2	Q9NQ36	805	871	847	856	Region	Note=Interaction with the cholesterol-anchor of SHH;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JJS0
SCUBE2	Q9NQ36	638	695	659	659	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCUBE2	Q9NQ36	85	127	90	102	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	85	127	98	111	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	85	127	113	126	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	363	402	368	378	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	363	402	374	387	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	363	402	389	401	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	402	443	407	418	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	402	443	414	427	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	402	443	429	442	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	805	871	809	835	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	805	871	862	883	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SCUBE2	Q9NQ36	517	569	444	569	Alternative sequence	ID=VSP_021293;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCUBE2	Q9NQ36	482	517	444	569	Alternative sequence	ID=VSP_021293;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCUBE2	Q9NQ36	443	482	444	569	Alternative sequence	ID=VSP_021293;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCUBE2	Q9NQ36	482	517	482	482	Alternative sequence	ID=VSP_021294;Note=In isoform 2. S->SGLQGAYSVTCGSSSPLRNKQQKSNDSAFG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCUBE2	Q9NQ36	443	482	482	482	Alternative sequence	ID=VSP_021294;Note=In isoform 2. S->SGLQGAYSVTCGSSSPLRNKQQKSNDSAFG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCUBE2	Q9NQ36	638	695	639	695	Alternative sequence	ID=VSP_039955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SCUBE2	Q9NQ36	805	871	806	872	Alternative sequence	ID=VSP_021295;Note=In isoform 3. NRRCGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTS->T;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCUBE2	Q9NQ36	805	871	843	843	Natural variant	ID=VAR_028874;Note=P->R;Dbxref=dbSNP:rs3751059
THAP6	Q8TBB0	96	138	1	222	Chain	ID=PRO_0000068647;Note=THAP domain-containing protein 6
THAP6	Q8TBB0	96	138	1	222	Chain	ID=PRO_0000068647;Note=THAP domain-containing protein 6
THAP6	Q8TBB0	96	138	97	138	Alternative sequence	ID=VSP_039072;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
THAP6	Q8TBB0	96	138	97	138	Alternative sequence	ID=VSP_039072;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SDAD1	Q9NVU7	237	271	1	687	Chain	ID=PRO_0000287482;Note=Protein SDA1 homolog
SDAD1	Q9NVU7	98	135	1	687	Chain	ID=PRO_0000287482;Note=Protein SDA1 homolog
SDAD1	Q9NVU7	237	271	253	315	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SDAD1	Q9NVU7	237	271	258	258	Natural variant	ID=VAR_032312;Note=K->Q;Dbxref=dbSNP:rs15481
SDHA	P31040	104	152	43	664	Chain	ID=PRO_0000010335;Note=Succinate dehydrogenase [ubiquinone] flavoprotein subunit%2C mitochondrial
SDHA	P31040	598	636	43	664	Chain	ID=PRO_0000010335;Note=Succinate dehydrogenase [ubiquinone] flavoprotein subunit%2C mitochondrial
SDHA	P31040	104	152	91	106	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q0QF01
SDHA	P31040	598	636	598	598	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K2B3
SDHA	P31040	598	636	608	608	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SDHA	P31040	598	636	615	615	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K2B3
SDHA	P31040	598	636	624	624	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K2B3
SDHA	P31040	598	636	636	636	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K2B3
SDHA	P31040	104	152	105	152	Alternative sequence	ID=VSP_055077;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SDHA	P31040	104	152	126	270	Alternative sequence	ID=VSP_055078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SDHA	P31040	598	636	629	629	Natural variant	ID=VAR_071037;Note=Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8142412,ECO:0000269|Ref.5;Dbxref=dbSNP:rs6960,PMID:15489334,PMID:8142412
SDHA	P31040	598	636	600	600	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SDHA	P31040	598	636	618	618	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC13	P55735	1	16	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895,ECO:0000269|PubMed:12665801,ECO:0000269|Ref.7;Dbxref=PMID:19413330,PMID:22223895,PMID:12665801
SEC13	P55735	1	16	2	322	Chain	ID=PRO_0000051203;Note=Protein SEC13 homolog
SEC13	P55735	1	16	11	50	Repeat	Note=WD 1
SEC13	P55735	1	16	2	2	Modified residue	Note=N-acetylvaline;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895,ECO:0000269|Ref.7;Dbxref=PMID:19413330,PMID:22223895
SEC13	P55735	1	16	1	14	Alternative sequence	ID=VSP_046191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9110174;Dbxref=PMID:9110174
SEC13	P55735	1	16	1	1	Alternative sequence	ID=VSP_054695;Note=In isoform 3. M->MREPVLTWCVPLELLCSHPLPLSAFLKSQVKLYTYRACAGKDEMGKM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC13	P55735	1	16	1	1	Alternative sequence	ID=VSP_058966;Note=In isoform 4. M->MGKM
SEC13	P55735	1	16	16	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BG1
SEC62	Q99442	203	243	1	399	Chain	ID=PRO_0000206616;Note=Translocation protein SEC62
SEC62	Q99442	203	243	1	399	Chain	ID=PRO_0000206616;Note=Translocation protein SEC62
SEC62	Q99442	203	243	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC62	Q99442	203	243	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC62	Q99442	203	243	218	234	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC62	Q99442	203	243	218	234	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC62	Q99442	203	243	235	255	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC62	Q99442	203	243	235	255	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACAT2	Q9BWD1	163	211	1	397	Chain	ID=PRO_0000206409;Note=Acetyl-CoA acetyltransferase%2C cytosolic
ACAT2	Q9BWD1	304	341	1	397	Chain	ID=PRO_0000206409;Note=Acetyl-CoA acetyltransferase%2C cytosolic
ACAT2	Q9BWD1	163	211	200	200	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACAT2	Q9BWD1	163	211	211	211	Natural variant	ID=VAR_019686;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs25683,PMID:15489334
ACAT2	Q9BWD1	163	211	169	169	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACAT2	Q9BWD1	163	211	160	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	163	211	175	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	163	211	195	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	163	211	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	304	341	297	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	304	341	312	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	304	341	317	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	304	341	325	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
ACAT2	Q9BWD1	304	341	339	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WL4
SEPT10	Q9P0V9	200	254	1	454	Chain	ID=PRO_0000173538;Note=Septin-10
SEPT10	Q9P0V9	10	33	1	454	Chain	ID=PRO_0000173538;Note=Septin-10
SEPT10	Q9P0V9	200	254	63	329	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT10	Q9P0V9	200	254	209	217	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SEPT10	Q9P0V9	200	254	208	211	Region	Note=G4 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT10	Q9P0V9	10	33	11	33	Alternative sequence	ID=VSP_041479;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN54	Q7Z6J9	19	73	1	526	Chain	ID=PRO_0000194029;Note=tRNA-splicing endonuclease subunit Sen54
TSEN54	Q7Z6J9	438	476	1	526	Chain	ID=PRO_0000194029;Note=tRNA-splicing endonuclease subunit Sen54
TSEN54	Q7Z6J9	438	476	178	526	Alternative sequence	ID=VSP_010989;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN54	Q7Z6J9	19	73	38	38	Natural variant	ID=VAR_019461;Note=H->Q;Dbxref=dbSNP:rs8079373
SENP2	Q9HC62	311	370	1	589	Chain	ID=PRO_0000101718;Note=Sentrin-specific protease 2
SENP2	Q9HC62	370	414	1	589	Chain	ID=PRO_0000101718;Note=Sentrin-specific protease 2
SENP2	Q9HC62	414	482	1	589	Chain	ID=PRO_0000101718;Note=Sentrin-specific protease 2
SENP2	Q9HC62	537	569	1	589	Chain	ID=PRO_0000101718;Note=Sentrin-specific protease 2
SENP2	Q9HC62	370	414	396	560	Region	Note=Protease
SENP2	Q9HC62	414	482	396	560	Region	Note=Protease
SENP2	Q9HC62	537	569	396	560	Region	Note=Protease
SENP2	Q9HC62	311	370	317	332	Motif	Note=Nuclear export signal
SENP2	Q9HC62	414	482	478	478	Active site	.
SENP2	Q9HC62	537	569	548	548	Active site	Note=Nucleophile
SENP2	Q9HC62	311	370	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SENP2	Q9HC62	311	370	344	344	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SENP2	Q9HC62	537	569	548	548	Mutagenesis	Note=Does not desumoylate CEBPB. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20194620;Dbxref=PMID:20194620
SENP2	Q9HC62	370	414	403	403	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SENP2	Q9HC62	311	370	370	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	370	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	381	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	388	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	396	398	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	399	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	403	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	370	414	413	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	413	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	435	437	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	442	454	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	455	458	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	463	465	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	466	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	414	482	479	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	537	569	536	538	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TH0
SENP2	Q9HC62	537	569	543	546	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	537	569	548	560	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP2	Q9HC62	537	569	569	571	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZO5
SENP3	Q9H4L4	405	421	1	574	Chain	ID=PRO_0000101721;Note=Sentrin-specific protease 3
SENP3	Q9H4L4	520	537	1	574	Chain	ID=PRO_0000101721;Note=Sentrin-specific protease 3
SENP3	Q9H4L4	405	421	1	574	Chain	ID=PRO_0000101721;Note=Sentrin-specific protease 3
SENP3	Q9H4L4	521	538	1	574	Chain	ID=PRO_0000101721;Note=Sentrin-specific protease 3
SENP3	Q9H4L4	405	421	386	543	Region	Note=Protease
SENP3	Q9H4L4	520	537	386	543	Region	Note=Protease
SENP3	Q9H4L4	405	421	386	543	Region	Note=Protease
SENP3	Q9H4L4	521	538	386	543	Region	Note=Protease
SENP3	Q9H4L4	520	537	532	532	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
SENP3	Q9H4L4	521	538	532	532	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
SENP3	Q9H4L4	520	537	532	532	Mutagenesis	Note=Loss of enzymatic activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18259216;Dbxref=PMID:18259216
SENP3	Q9H4L4	521	538	532	532	Mutagenesis	Note=Loss of enzymatic activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18259216;Dbxref=PMID:18259216
SEMA7A	O75326	110	124	45	648	Chain	ID=PRO_0000032347;Note=Semaphorin-7A
SEMA7A	O75326	110	124	53	490	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA7A	O75326	110	124	120	126	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20727575;Dbxref=PMID:20727575
SEMA7A	O75326	110	124	111	124	Alternative sequence	ID=VSP_045349;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEMA7A	O75326	110	124	115	115	Natural variant	ID=VAR_029282;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs16968733
SEMA7A	O75326	110	124	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NVQ
SEPT7	Q16181	127	171	2	437	Chain	ID=PRO_0000173528;Note=Septin-7
SEPT7	Q16181	292	333	2	437	Chain	ID=PRO_0000173528;Note=Septin-7
SEPT7	Q16181	127	171	47	316	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT7	Q16181	292	333	47	316	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT7	Q16181	127	171	47	317	Region	Note=Interaction with SEPT12;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25588830;Dbxref=PMID:25588830
SEPT7	Q16181	292	333	47	317	Region	Note=Interaction with SEPT12;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25588830;Dbxref=PMID:25588830
SEPT7	Q16181	292	333	332	437	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SEPT7	Q16181	127	171	124	127	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5D
SEPT7	Q16181	127	171	128	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5D
SEPT7	Q16181	127	171	147	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TW4
SEPT7	Q16181	127	171	160	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5D
SEPT7	Q16181	292	333	291	293	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5D
SEPT7	Q16181	292	333	294	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5D
SEPT7	Q16181	292	333	305	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5D
PSPH	P78330	47	91	1	225	Chain	ID=PRO_0000156879;Note=Phosphoserine phosphatase
PSPH	P78330	47	91	1	225	Chain	ID=PRO_0000156879;Note=Phosphoserine phosphatase
PSPH	P78330	47	91	65	65	Binding site	Note=Substrate
PSPH	P78330	47	91	65	65	Binding site	Note=Substrate
PSPH	P78330	47	91	52	52	Natural variant	ID=VAR_022379;Note=In PSPHD. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14673469;Dbxref=dbSNP:rs104894036,PMID:14673469
PSPH	P78330	47	91	52	52	Natural variant	ID=VAR_022379;Note=In PSPHD. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14673469;Dbxref=dbSNP:rs104894036,PMID:14673469
PSPH	P78330	47	91	65	65	Mutagenesis	Note=Loss of activity. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12213811;Dbxref=PMID:12213811
PSPH	P78330	47	91	65	65	Mutagenesis	Note=Loss of activity. R->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12213811;Dbxref=PMID:12213811
PSPH	P78330	47	91	45	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8L
PSPH	P78330	47	91	45	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8L
PSPH	P78330	47	91	49	52	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8L
PSPH	P78330	47	91	49	52	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L8L
PSPH	P78330	47	91	58	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NNL
PSPH	P78330	47	91	58	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NNL
PSPH	P78330	47	91	73	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NNL
PSPH	P78330	47	91	73	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NNL
PSPH	P78330	47	91	91	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NNL
PSPH	P78330	47	91	91	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NNL
SERINC3	Q13530	158	204	1	473	Chain	ID=PRO_0000218970;Note=Serine incorporator 3
SERINC3	Q13530	13	67	1	473	Chain	ID=PRO_0000218970;Note=Serine incorporator 3
SERINC3	Q13530	158	204	1	473	Chain	ID=PRO_0000218970;Note=Serine incorporator 3
SERINC3	Q13530	13	67	1	473	Chain	ID=PRO_0000218970;Note=Serine incorporator 3
SERINC3	Q13530	13	67	1	96	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	13	67	1	96	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	154	159	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	154	159	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	181	203	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	181	203	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	204	224	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	158	204	204	224	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	13	67	34	34	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	13	67	34	34	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC3	Q13530	13	67	1	55	Alternative sequence	ID=VSP_056833;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERINC3	Q13530	13	67	1	55	Alternative sequence	ID=VSP_056833;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SETD5	Q9C0A6	594	701	1	1442	Chain	ID=PRO_0000281905;Note=SET domain-containing protein 5
SETD5	Q9C0A6	908	1065	1	1442	Chain	ID=PRO_0000281905;Note=SET domain-containing protein 5
SETD5	Q9C0A6	594	701	1	1442	Chain	ID=PRO_0000281905;Note=SET domain-containing protein 5
SETD5	Q9C0A6	908	1065	1	1442	Chain	ID=PRO_0000281905;Note=SET domain-containing protein 5
SETD5	Q9C0A6	594	701	399	1442	Natural variant	ID=VAR_078955;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=dbSNP:rs587777325,PMID:24680889
SETD5	Q9C0A6	908	1065	399	1442	Natural variant	ID=VAR_078955;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=dbSNP:rs587777325,PMID:24680889
SETD5	Q9C0A6	594	701	399	1442	Natural variant	ID=VAR_078955;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=dbSNP:rs587777325,PMID:24680889
SETD5	Q9C0A6	908	1065	399	1442	Natural variant	ID=VAR_078955;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=dbSNP:rs587777325,PMID:24680889
SETD5	Q9C0A6	594	701	445	1442	Natural variant	ID=VAR_078956;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	908	1065	445	1442	Natural variant	ID=VAR_078956;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	594	701	445	1442	Natural variant	ID=VAR_078956;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	908	1065	445	1442	Natural variant	ID=VAR_078956;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	594	701	622	1442	Natural variant	ID=VAR_078957;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	908	1065	622	1442	Natural variant	ID=VAR_078957;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	594	701	622	1442	Natural variant	ID=VAR_078957;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	908	1065	622	1442	Natural variant	ID=VAR_078957;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=PMID:24680889
SETD5	Q9C0A6	908	1065	768	1442	Natural variant	ID=VAR_078958;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25138099;Dbxref=dbSNP:rs864321657,PMID:25138099
SETD5	Q9C0A6	908	1065	768	1442	Natural variant	ID=VAR_078958;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25138099;Dbxref=dbSNP:rs864321657,PMID:25138099
SETD5	Q9C0A6	908	1065	973	1442	Natural variant	ID=VAR_078959;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27375234;Dbxref=PMID:27375234
SETD5	Q9C0A6	908	1065	973	1442	Natural variant	ID=VAR_078959;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27375234;Dbxref=PMID:27375234
SETD5	Q9C0A6	908	1065	1001	1442	Natural variant	ID=VAR_078960;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=dbSNP:rs587777327,PMID:24680889
SETD5	Q9C0A6	908	1065	1001	1442	Natural variant	ID=VAR_078960;Note=In MRD23. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24680889;Dbxref=dbSNP:rs587777327,PMID:24680889
SETD5	Q9C0A6	908	1065	985	985	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SETD5	Q9C0A6	908	1065	985	985	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	1	2005	Chain	ID=PRO_0000048491;Note=Sodium channel protein type 2 subunit alpha
SCN2A	Q99250	1225	1283	1	2005	Chain	ID=PRO_0000048491;Note=Sodium channel protein type 2 subunit alpha
SCN2A	Q99250	796	854	1	2005	Chain	ID=PRO_0000048491;Note=Sodium channel protein type 2 subunit alpha
SCN2A	Q99250	1225	1283	1	2005	Chain	ID=PRO_0000048491;Note=Sodium channel protein type 2 subunit alpha
SCN2A	Q99250	796	854	790	809	Transmembrane	Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	796	854	790	809	Transmembrane	Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	796	854	810	823	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	810	823	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	824	843	Transmembrane	Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	796	854	824	843	Transmembrane	Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	796	854	844	845	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	844	845	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	846	863	Transmembrane	Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	796	854	846	863	Transmembrane	Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	1225	1283	1210	1227	Transmembrane	Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	1225	1283	1210	1227	Transmembrane	Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	1225	1283	1228	1240	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	1225	1283	1228	1240	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	1225	1283	1241	1259	Transmembrane	Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	1225	1283	1241	1259	Transmembrane	Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	1225	1283	1260	1273	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	1225	1283	1260	1273	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	1225	1283	1274	1292	Transmembrane	Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	1225	1283	1274	1292	Transmembrane	Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN2A	Q99250	796	854	741	1013	Repeat	Note=II;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	741	1013	Repeat	Note=II;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	1225	1283	1190	1504	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	1225	1283	1190	1504	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN2A	Q99250	796	854	102	2005	Natural variant	ID=VAR_078450;Note=Probable disease-associated mutation found in a patient with intractable epilepsy and severe mental decline%3B non-conducting%3B loss of voltage-gated sodium channel activity%3B dominant-negatif. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15028761;Dbxref=PMID:15028761
SCN2A	Q99250	1225	1283	102	2005	Natural variant	ID=VAR_078450;Note=Probable disease-associated mutation found in a patient with intractable epilepsy and severe mental decline%3B non-conducting%3B loss of voltage-gated sodium channel activity%3B dominant-negatif. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15028761;Dbxref=PMID:15028761
SCN2A	Q99250	796	854	102	2005	Natural variant	ID=VAR_078450;Note=Probable disease-associated mutation found in a patient with intractable epilepsy and severe mental decline%3B non-conducting%3B loss of voltage-gated sodium channel activity%3B dominant-negatif. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15028761;Dbxref=PMID:15028761
SCN2A	Q99250	1225	1283	102	2005	Natural variant	ID=VAR_078450;Note=Probable disease-associated mutation found in a patient with intractable epilepsy and severe mental decline%3B non-conducting%3B loss of voltage-gated sodium channel activity%3B dominant-negatif. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15028761;Dbxref=PMID:15028761
SCN2A	Q99250	796	854	169	2005	Natural variant	ID=VAR_078453;Note=Found in a patient with schizofrenia%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=PMID:26555645
SCN2A	Q99250	1225	1283	169	2005	Natural variant	ID=VAR_078453;Note=Found in a patient with schizofrenia%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=PMID:26555645
SCN2A	Q99250	796	854	169	2005	Natural variant	ID=VAR_078453;Note=Found in a patient with schizofrenia%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=PMID:26555645
SCN2A	Q99250	1225	1283	169	2005	Natural variant	ID=VAR_078453;Note=Found in a patient with schizofrenia%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=PMID:26555645
SCN2A	Q99250	796	854	583	2005	Natural variant	ID=VAR_078732;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25969726;Dbxref=PMID:25969726
SCN2A	Q99250	1225	1283	583	2005	Natural variant	ID=VAR_078732;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25969726;Dbxref=PMID:25969726
SCN2A	Q99250	796	854	583	2005	Natural variant	ID=VAR_078732;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25969726;Dbxref=PMID:25969726
SCN2A	Q99250	1225	1283	583	2005	Natural variant	ID=VAR_078732;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25969726;Dbxref=PMID:25969726
SCN2A	Q99250	796	854	850	850	Natural variant	ID=VAR_078459;Note=Found in a patient with schizofrenia%3B unknown pathological significance. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=PMID:26555645
SCN2A	Q99250	796	854	850	850	Natural variant	ID=VAR_078459;Note=Found in a patient with schizofrenia%3B unknown pathological significance. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=PMID:26555645
SCN2A	Q99250	796	854	853	853	Natural variant	ID=VAR_070001;Note=In EIEE11%3B phenotype consistent with West syndrome. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23935176;Dbxref=dbSNP:rs794727152,PMID:23935176
SCN2A	Q99250	796	854	853	853	Natural variant	ID=VAR_070001;Note=In EIEE11%3B phenotype consistent with West syndrome. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23935176;Dbxref=dbSNP:rs794727152,PMID:23935176
SCN2A	Q99250	1225	1283	959	2005	Natural variant	ID=VAR_078466;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder%3B loss of voltage-gated sodium channel activity%3B non-conducting. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28256214;Dbxref=PMID:28256214
SCN2A	Q99250	1225	1283	959	2005	Natural variant	ID=VAR_078466;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder%3B loss of voltage-gated sodium channel activity%3B non-conducting. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28256214;Dbxref=PMID:28256214
SCN2A	Q99250	1225	1283	1013	2005	Natural variant	ID=VAR_078469;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder%3B loss of voltage-gated sodium channel activity%3B non-conducting. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28256214;Dbxref=PMID:28256214
SCN2A	Q99250	1225	1283	1013	2005	Natural variant	ID=VAR_078469;Note=Probable disease-associated mutation found in a patient with autism spectrum disorder%3B loss of voltage-gated sodium channel activity%3B non-conducting. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28256214;Dbxref=PMID:28256214
SCN2A	Q99250	1225	1283	1260	1260	Natural variant	ID=VAR_078738;Note=In EIEE11. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN2A	Q99250	1225	1283	1260	1260	Natural variant	ID=VAR_078738;Note=In EIEE11. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN2A	Q99250	1225	1283	1260	1260	Natural variant	ID=VAR_078739;Note=In EIEE11. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN2A	Q99250	1225	1283	1260	1260	Natural variant	ID=VAR_078739;Note=In EIEE11. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26993267;Dbxref=PMID:26993267
SCN2A	Q99250	1225	1283	1282	1282	Natural variant	ID=VAR_078471;Note=Found in a patient with schizofrenia%3B unknown pathological significance. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=dbSNP:rs1184922927,PMID:26555645
SCN2A	Q99250	1225	1283	1282	1282	Natural variant	ID=VAR_078471;Note=Found in a patient with schizofrenia%3B unknown pathological significance. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26555645;Dbxref=dbSNP:rs1184922927,PMID:26555645
SENP5	Q96HI0	586	602	1	755	Chain	ID=PRO_0000101723;Note=Sentrin-specific protease 5
SENP5	Q96HI0	628	674	1	755	Chain	ID=PRO_0000101723;Note=Sentrin-specific protease 5
SENP5	Q96HI0	674	702	1	755	Chain	ID=PRO_0000101723;Note=Sentrin-specific protease 5
SENP5	Q96HI0	586	602	567	724	Region	Note=Protease
SENP5	Q96HI0	628	674	567	724	Region	Note=Protease
SENP5	Q96HI0	674	702	567	724	Region	Note=Protease
SENP5	Q96HI0	628	674	646	646	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
SENP5	Q96HI0	628	674	663	663	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
SENP5	Q96HI0	628	674	629	674	Alternative sequence	ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SENP5	Q96HI0	674	702	629	674	Alternative sequence	ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SENP7	Q9BQF6	786	826	1	1050	Chain	ID=PRO_0000101726;Note=Sentrin-specific protease 7
SENP7	Q9BQF6	161	225	1	1050	Chain	ID=PRO_0000101726;Note=Sentrin-specific protease 7
SENP7	Q9BQF6	95	160	1	1050	Chain	ID=PRO_0000101726;Note=Sentrin-specific protease 7
SENP7	Q9BQF6	786	826	760	1050	Region	Note=Protease
SENP7	Q9BQF6	786	826	1	812	Alternative sequence	ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SENP7	Q9BQF6	161	225	1	812	Alternative sequence	ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SENP7	Q9BQF6	95	160	1	812	Alternative sequence	ID=VSP_039498;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SENP7	Q9BQF6	161	225	95	225	Alternative sequence	ID=VSP_039501;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SENP7	Q9BQF6	95	160	95	225	Alternative sequence	ID=VSP_039501;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SENP7	Q9BQF6	95	160	95	160	Alternative sequence	ID=VSP_039500;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
SENP7	Q9BQF6	786	826	813	827	Alternative sequence	ID=VSP_039502;Note=In isoform 3. TRKENNLTEDNPNLS->MKKFLYIKSVFHTLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SENP7	Q9BQF6	786	826	778	791	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY
SENP7	Q9BQF6	786	826	795	799	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY
SENP7	Q9BQF6	786	826	801	803	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY
SENP7	Q9BQF6	786	826	807	812	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAY
SEMA4C	Q9C0C4	172	211	21	833	Chain	ID=PRO_0000032325;Note=Semaphorin-4C
SEMA4C	Q9C0C4	172	211	21	663	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4C	Q9C0C4	172	211	30	497	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4C	Q9C0C4	172	211	46	489	Region	Note=Dominant negative effect on myogenic differentiation;Ontology_term=ECO:0000250;evidence=ECO:0000250
TSEN2	Q8NCE0	277	303	1	465	Chain	ID=PRO_0000109452;Note=tRNA-splicing endonuclease subunit Sen2
TSEN2	Q8NCE0	303	320	1	465	Chain	ID=PRO_0000109452;Note=tRNA-splicing endonuclease subunit Sen2
TSEN2	Q8NCE0	277	303	1	465	Chain	ID=PRO_0000109452;Note=tRNA-splicing endonuclease subunit Sen2
TSEN2	Q8NCE0	303	320	1	465	Chain	ID=PRO_0000109452;Note=tRNA-splicing endonuclease subunit Sen2
TSEN2	Q8NCE0	277	303	276	301	Alternative sequence	ID=VSP_046193;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN2	Q8NCE0	277	303	276	301	Alternative sequence	ID=VSP_046193;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN2	Q8NCE0	277	303	278	303	Alternative sequence	ID=VSP_010985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN2	Q8NCE0	303	320	278	303	Alternative sequence	ID=VSP_010985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN2	Q8NCE0	277	303	278	303	Alternative sequence	ID=VSP_010985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN2	Q8NCE0	303	320	278	303	Alternative sequence	ID=VSP_010985;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSEN2	Q8NCE0	303	320	304	320	Alternative sequence	ID=VSP_010986;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15109492;Dbxref=PMID:15109492
TSEN2	Q8NCE0	303	320	304	320	Alternative sequence	ID=VSP_010986;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15109492;Dbxref=PMID:15109492
TSEN2	Q8NCE0	303	320	309	309	Natural variant	ID=VAR_054810;Note=In PCH2B. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18711368;Dbxref=dbSNP:rs113994149,PMID:18711368
TSEN2	Q8NCE0	303	320	309	309	Natural variant	ID=VAR_054810;Note=In PCH2B. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18711368;Dbxref=dbSNP:rs113994149,PMID:18711368
SEPT2	Q15019	43	72	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	281	308	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	43	72	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	281	308	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	43	72	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	281	308	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	43	72	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	281	308	1	361	Chain	ID=PRO_0000173515;Note=Septin-2
SEPT2	Q15019	43	72	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	281	308	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	281	308	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	281	308	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	281	308	34	306	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	44	51	Nucleotide binding	Note=GTP
SEPT2	Q15019	43	72	44	51	Nucleotide binding	Note=GTP
SEPT2	Q15019	43	72	44	51	Nucleotide binding	Note=GTP
SEPT2	Q15019	43	72	44	51	Nucleotide binding	Note=GTP
SEPT2	Q15019	43	72	44	51	Region	Note=G1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	44	51	Region	Note=G1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	44	51	Region	Note=G1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	44	51	Region	Note=G1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT2	Q15019	43	72	72	72	Alternative sequence	ID=VSP_055176;Note=In isoform 3. A->AALNTRKTLLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
SEPT2	Q15019	43	72	72	72	Alternative sequence	ID=VSP_055176;Note=In isoform 3. A->AALNTRKTLLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
SEPT2	Q15019	43	72	72	72	Alternative sequence	ID=VSP_055176;Note=In isoform 3. A->AALNTRKTLLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
SEPT2	Q15019	43	72	72	72	Alternative sequence	ID=VSP_055176;Note=In isoform 3. A->AALNTRKTLLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
SEPT2	Q15019	43	72	69	69	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEPT2	Q15019	43	72	69	69	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEPT2	Q15019	43	72	69	69	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEPT2	Q15019	43	72	69	69	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEPT2	Q15019	43	72	38	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	38	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	38	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	38	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	50	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	50	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	50	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	43	72	50	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	273	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	273	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	273	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	273	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	295	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	295	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	295	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SEPT2	Q15019	281	308	295	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QNR
SERINC2	Q96SA4	338	410	1	455	Chain	ID=PRO_0000218968;Note=Serine incorporator 2
SERINC2	Q96SA4	338	410	317	339	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC2	Q96SA4	338	410	385	407	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	368	368	Sequence conflict	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERINC2	Q96SA4	338	410	382	382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SESTD1	Q86VW0	508	549	1	696	Chain	ID=PRO_0000309479;Note=SEC14 domain and spectrin repeat-containing protein 1
SESTD1	Q86VW0	85	123	1	696	Chain	ID=PRO_0000309479;Note=SEC14 domain and spectrin repeat-containing protein 1
SESTD1	Q86VW0	85	123	1	153	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
SESTD1	Q86VW0	508	549	500	602	Repeat	Note=Spectrin 3
SESTD1	Q86VW0	508	549	508	508	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCAF4	O95104	200	259	1	1147	Chain	ID=PRO_0000081943;Note=Splicing factor%2C arginine/serine-rich 15
SCAF4	O95104	38	53	1	1147	Chain	ID=PRO_0000081943;Note=Splicing factor%2C arginine/serine-rich 15
SCAF4	O95104	38	53	1	139	Domain	Note=CID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00724
SCAF4	O95104	38	53	49	49	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SCAF4	O95104	38	53	38	52	Alternative sequence	ID=VSP_047351;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SH2B1	Q9NRF2	436	504	1	756	Chain	ID=PRO_0000323593;Note=SH2B adapter protein 1
SH2B1	Q9NRF2	436	504	1	555	Region	Note=Interaction with JAK2 (low-affinity binding%3B independent of JAK2 phosphorylation);Ontology_term=ECO:0000250;evidence=ECO:0000250
SH2B1	Q9NRF2	436	504	439	439	Modified residue	Note=Phosphotyrosine%3B by JAK1%2C JAK2 and PDGFR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62985
SH2B1	Q9NRF2	436	504	494	494	Modified residue	Note=Phosphotyrosine%3B by JAK1%2C JAK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62985
SH2B1	Q9NRF2	436	504	484	484	Natural variant	ID=VAR_039550;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15767667,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs7498665,PMID:15767667,PMID:17974005
SGPL1	O95470	270	303	1	568	Chain	ID=PRO_0000147012;Note=Sphingosine-1-phosphate lyase 1
SGPL1	O95470	303	353	1	568	Chain	ID=PRO_0000147012;Note=Sphingosine-1-phosphate lyase 1
SGPL1	O95470	270	303	62	568	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGPL1	O95470	303	353	62	568	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGPL1	O95470	303	353	353	353	Modified residue	Note=N6-(pyridoxal phosphate)lysine%3B alternate
SGPL1	O95470	303	353	353	353	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SGPL1	O95470	303	353	346	346	Natural variant	ID=VAR_079215;Note=In NPHS1%3B decreased protein abundance in cells of patients homozygous for the mutation%3B increased aggregation%3B decreased sphinganine-1-phosphate aldolase activity. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28165339;Dbxref=dbSNP:rs1131692256,PMID:28165339
SGPL1	O95470	303	353	317	317	Mutagenesis	Note=Almost no sphinganine-1-phosphate aldolase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11018465;Dbxref=PMID:11018465
SGPL1	O95470	303	353	353	353	Mutagenesis	Note=Loss of sphinganine-1-phosphate aldolase activity. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14570870;Dbxref=PMID:14570870
SGPL1	O95470	270	303	269	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	270	303	280	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	270	303	290	292	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	270	303	298	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	303	353	298	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	303	353	312	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	303	353	317	319	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	303	353	320	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	303	353	324	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SGPL1	O95470	303	353	344	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q6R
SHKBP1	Q8TBC3	388	445	2	707	Chain	ID=PRO_0000307932;Note=SH3KBP1-binding protein 1
SHKBP1	Q8TBC3	445	497	2	707	Chain	ID=PRO_0000307932;Note=SH3KBP1-binding protein 1
SHKBP1	Q8TBC3	388	445	363	420	Repeat	Note=WD 5
SHKBP1	Q8TBC3	388	445	421	466	Repeat	Note=WD 6
SHKBP1	Q8TBC3	445	497	421	466	Repeat	Note=WD 6
SHKBP1	Q8TBC3	445	497	467	518	Repeat	Note=WD 7
SHKBP1	Q8TBC3	388	445	306	707	Alternative sequence	ID=VSP_028874;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SHKBP1	Q8TBC3	445	497	306	707	Alternative sequence	ID=VSP_028874;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SHROOM1	Q2M3G4	414	603	1	852	Chain	ID=PRO_0000286061;Note=Protein Shroom1
SHROOM1	Q2M3G4	345	413	1	852	Chain	ID=PRO_0000286061;Note=Protein Shroom1
SHROOM1	Q2M3G4	414	603	543	825	Domain	Note=ASD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00638
SH3KBP1	Q96B97	498	541	1	665	Chain	ID=PRO_0000097728;Note=SH3 domain-containing kinase-binding protein 1
SH3KBP1	Q96B97	299	335	1	665	Chain	ID=PRO_0000097728;Note=SH3 domain-containing kinase-binding protein 1
SH3KBP1	Q96B97	299	335	267	328	Domain	Note=SH3 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3KBP1	Q96B97	299	335	327	428	Compositional bias	Note=Pro-rich
SH3KBP1	Q96B97	498	541	509	509	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
SH3KBP1	Q96B97	498	541	511	511	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
SH3KBP1	Q96B97	498	541	521	521	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SH3KBP1	Q96B97	299	335	293	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YDL
SH3KBP1	Q96B97	299	335	301	303	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K9G
SH3KBP1	Q96B97	299	335	306	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YDL
SH3KBP1	Q96B97	299	335	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YDL
SH3KBP1	Q96B97	299	335	320	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YDL
SH3KBP1	Q96B97	299	335	323	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YDL
SIPA1L1	O43166	1035	1124	1	1804	Chain	ID=PRO_0000056746;Note=Signal-induced proliferation-associated 1-like protein 1
SIPA1L1	O43166	1125	1173	1	1804	Chain	ID=PRO_0000056746;Note=Signal-induced proliferation-associated 1-like protein 1
SIPA1L1	O43166	1215	1236	1	1804	Chain	ID=PRO_0000056746;Note=Signal-induced proliferation-associated 1-like protein 1
SIPA1L1	O43166	1035	1124	967	1045	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SIPA1L1	O43166	1125	1173	1154	1157	Compositional bias	Note=Poly-Ser
SIPA1L1	O43166	1035	1124	1078	1078	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SIPA1L1	O43166	1035	1124	1087	1087	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SIPA1L1	O43166	1035	1124	1116	1116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SIPA1L1	O43166	1125	1173	1127	1127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C0T5
SIPA1L1	O43166	1125	1173	1149	1149	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SIPA1L1	O43166	1125	1173	1170	1170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SIPA1L1	O43166	1215	1236	1216	1236	Alternative sequence	ID=VSP_010917;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9858596;Dbxref=PMID:14702039,PMID:9858596
SIGLEC11	Q96RL6	454	550	28	698	Chain	ID=PRO_0000014951;Note=Sialic acid-binding Ig-like lectin 11
SIGLEC11	Q96RL6	454	550	28	561	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC11	Q96RL6	454	550	497	497	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC11	Q96RL6	454	550	515	515	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC11	Q96RL6	454	550	455	551	Alternative sequence	ID=VSP_008764;Note=In isoform 2. YPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPG->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
ST8SIA4	Q92187	168	265	1	359	Chain	ID=PRO_0000149293;Note=CMP-N-acetylneuraminate-poly-alpha-2%2C8-sialyltransferase
ST8SIA4	Q92187	82	167	1	359	Chain	ID=PRO_0000149293;Note=CMP-N-acetylneuraminate-poly-alpha-2%2C8-sialyltransferase
ST8SIA4	Q92187	168	265	21	359	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA4	Q92187	82	167	21	359	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA4	Q92187	168	265	191	193	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA4	Q92187	168	265	170	170	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA4	Q92187	82	167	119	119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA4	Q92187	168	265	204	204	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA4	Q92187	168	265	219	219	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA4	Q92187	168	265	142	292	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11279095;Dbxref=PMID:11279095
ST8SIA4	Q92187	82	167	142	292	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11279095;Dbxref=PMID:11279095
ST8SIA4	Q92187	168	265	156	356	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11279095;Dbxref=PMID:11279095
ST8SIA4	Q92187	82	167	156	356	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11279095;Dbxref=PMID:11279095
ST8SIA4	Q92187	168	265	169	359	Alternative sequence	ID=VSP_044867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ST8SIA4	Q92187	82	167	92	92	Natural variant	ID=VAR_036169;Note=In a colorectal cancer sample%3B somatic mutation. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ST8SIA4	Q92187	168	265	260	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y22
LARS	Q9P2J5	626	696	1	1176	Chain	ID=PRO_0000152150;Note=Leucine--tRNA ligase%2C cytoplasmic
LARS	Q9P2J5	475	501	1	1176	Chain	ID=PRO_0000152150;Note=Leucine--tRNA ligase%2C cytoplasmic
LARS	Q9P2J5	410	428	1	1176	Chain	ID=PRO_0000152150;Note=Leucine--tRNA ligase%2C cytoplasmic
LARS	Q9P2J5	144	198	1	1176	Chain	ID=PRO_0000152150;Note=Leucine--tRNA ligase%2C cytoplasmic
LARS	Q9P2J5	98	144	1	1176	Chain	ID=PRO_0000152150;Note=Leucine--tRNA ligase%2C cytoplasmic
LARS	Q9P2J5	71	98	1	1176	Chain	ID=PRO_0000152150;Note=Leucine--tRNA ligase%2C cytoplasmic
LARS	Q9P2J5	475	501	260	509	Region	Note=Editing domain
LARS	Q9P2J5	410	428	260	509	Region	Note=Editing domain
LARS	Q9P2J5	144	198	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LARS	Q9P2J5	626	696	1	691	Alternative sequence	ID=VSP_057204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LARS	Q9P2J5	475	501	1	691	Alternative sequence	ID=VSP_057204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LARS	Q9P2J5	410	428	1	691	Alternative sequence	ID=VSP_057204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LARS	Q9P2J5	144	198	1	691	Alternative sequence	ID=VSP_057204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LARS	Q9P2J5	98	144	1	691	Alternative sequence	ID=VSP_057204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LARS	Q9P2J5	71	98	1	691	Alternative sequence	ID=VSP_057204;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
LARS	Q9P2J5	71	98	82	82	Natural variant	ID=VAR_070437;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22607940;Dbxref=dbSNP:rs112954500,PMID:22607940
LARS	Q9P2J5	410	428	411	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFD
LARS	Q9P2J5	410	428	415	417	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFD
LARS	Q9P2J5	410	428	420	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFD
LARS	Q9P2J5	410	428	423	425	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFD
LARS	Q9P2J5	475	501	487	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WFD
TRERF1	Q96PN7	953	1022	1	1200	Chain	ID=PRO_0000197134;Note=Transcriptional-regulating factor 1
TRERF1	Q96PN7	545	628	1	1200	Chain	ID=PRO_0000197134;Note=Transcriptional-regulating factor 1
TRERF1	Q96PN7	953	1022	1013	1037	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
TRERF1	Q96PN7	953	1022	439	1200	Region	Note=Interaction with CREBBP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349124;Dbxref=PMID:11349124
TRERF1	Q96PN7	545	628	439	1200	Region	Note=Interaction with CREBBP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349124;Dbxref=PMID:11349124
TRERF1	Q96PN7	545	628	553	749	Compositional bias	Note=Pro-rich
TRERF1	Q96PN7	953	1022	956	982	Compositional bias	Note=Glu-rich
TRERF1	Q96PN7	953	1022	954	954	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
TRERF1	Q96PN7	953	1022	955	955	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
TRERF1	Q96PN7	545	628	546	628	Alternative sequence	ID=VSP_015645;Note=In isoform 2%2C isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TRERF1	Q96PN7	953	1022	1022	1022	Alternative sequence	ID=VSP_015646;Note=In isoform 3 and isoform 5. A->ADCRCHVTPFLPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TRERF1	Q96PN7	953	1022	1019	1019	Natural variant	ID=VAR_050199;Note=N->T;Dbxref=dbSNP:rs35978318
TRIM36	Q9NQ86	257	289	1	728	Chain	ID=PRO_0000056252;Note=E3 ubiquitin-protein ligase TRIM36
TRIM36	Q9NQ86	257	289	271	345	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM36	Q9NQ86	257	289	61	728	Alternative sequence	ID=VSP_043512;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRIM36	Q9NQ86	257	289	62	728	Alternative sequence	ID=VSP_045792;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SYTL3	Q4VX76	379	436	1	610	Chain	ID=PRO_0000311116;Note=Synaptotagmin-like protein 3
SYTL3	Q4VX76	311	368	1	610	Chain	ID=PRO_0000311116;Note=Synaptotagmin-like protein 3
SYTL3	Q4VX76	379	436	308	412	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYTL3	Q4VX76	311	368	308	412	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYTL3	Q4VX76	379	436	414	414	Natural variant	ID=VAR_037137;Note=P->S;Dbxref=dbSNP:rs901363
TMEM120B	A0PK00	154	183	1	339	Chain	ID=PRO_0000309529;Note=Transmembrane protein 120B
TMEM120B	A0PK00	226	257	1	339	Chain	ID=PRO_0000309529;Note=Transmembrane protein 120B
TMEM120B	A0PK00	154	183	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	95	114	1	235	Chain	ID=PRO_0000279872;Note=Transmembrane protein 176A
TMEM176A	Q96HP8	185	222	1	235	Chain	ID=PRO_0000279872;Note=Transmembrane protein 176A
TMEM176A	Q96HP8	95	114	1	235	Chain	ID=PRO_0000279872;Note=Transmembrane protein 176A
TMEM176A	Q96HP8	185	222	1	235	Chain	ID=PRO_0000279872;Note=Transmembrane protein 176A
TMEM176A	Q96HP8	95	114	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	95	114	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	95	114	113	133	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	95	114	113	133	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	185	222	193	213	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	185	222	193	213	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176A	Q96HP8	185	222	187	187	Natural variant	ID=VAR_031033;Note=L->F;Dbxref=dbSNP:rs10378
TMEM176A	Q96HP8	185	222	187	187	Natural variant	ID=VAR_031033;Note=L->F;Dbxref=dbSNP:rs10378
TMEM176A	Q96HP8	185	222	208	208	Natural variant	ID=VAR_031034;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12097419;Dbxref=dbSNP:rs9088,PMID:12097419
TMEM176A	Q96HP8	185	222	208	208	Natural variant	ID=VAR_031034;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12097419;Dbxref=dbSNP:rs9088,PMID:12097419
TMEM176B	Q3YBM2	68	105	1	270	Chain	ID=PRO_0000279875;Note=Transmembrane protein 176B
TMEM176B	Q3YBM2	68	105	1	270	Chain	ID=PRO_0000279875;Note=Transmembrane protein 176B
TMEM176B	Q3YBM2	68	105	1	270	Chain	ID=PRO_0000279875;Note=Transmembrane protein 176B
TMEM176B	Q3YBM2	68	105	1	270	Chain	ID=PRO_0000279875;Note=Transmembrane protein 176B
TMEM176B	Q3YBM2	68	105	1	270	Chain	ID=PRO_0000279875;Note=Transmembrane protein 176B
TMEM176B	Q3YBM2	68	105	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM176B	Q3YBM2	68	105	69	105	Alternative sequence	ID=VSP_046283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM176B	Q3YBM2	68	105	69	105	Alternative sequence	ID=VSP_046283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM176B	Q3YBM2	68	105	69	105	Alternative sequence	ID=VSP_046283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM176B	Q3YBM2	68	105	69	105	Alternative sequence	ID=VSP_046283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM176B	Q3YBM2	68	105	69	105	Alternative sequence	ID=VSP_046283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM176B	Q3YBM2	68	105	70	70	Natural variant	ID=VAR_031036;Note=T->A;Dbxref=dbSNP:rs28434777
TMEM176B	Q3YBM2	68	105	70	70	Natural variant	ID=VAR_031036;Note=T->A;Dbxref=dbSNP:rs28434777
TMEM176B	Q3YBM2	68	105	70	70	Natural variant	ID=VAR_031036;Note=T->A;Dbxref=dbSNP:rs28434777
TMEM176B	Q3YBM2	68	105	70	70	Natural variant	ID=VAR_031036;Note=T->A;Dbxref=dbSNP:rs28434777
TMEM176B	Q3YBM2	68	105	70	70	Natural variant	ID=VAR_031036;Note=T->A;Dbxref=dbSNP:rs28434777
TMEM176B	Q3YBM2	68	105	94	94	Natural variant	ID=VAR_031037;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9922225,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3173833,PMID:15489334,PMID:9922225
TMEM176B	Q3YBM2	68	105	94	94	Natural variant	ID=VAR_031037;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9922225,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3173833,PMID:15489334,PMID:9922225
TMEM176B	Q3YBM2	68	105	94	94	Natural variant	ID=VAR_031037;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9922225,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3173833,PMID:15489334,PMID:9922225
TMEM176B	Q3YBM2	68	105	94	94	Natural variant	ID=VAR_031037;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9922225,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3173833,PMID:15489334,PMID:9922225
TMEM176B	Q3YBM2	68	105	94	94	Natural variant	ID=VAR_031037;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9922225,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3173833,PMID:15489334,PMID:9922225
TAF12	Q16514	56	82	1	161	Chain	ID=PRO_0000033580;Note=Transcription initiation factor TFIID subunit 12
TAF12	Q16514	56	82	1	161	Chain	ID=PRO_0000033580;Note=Transcription initiation factor TFIID subunit 12
TAF12	Q16514	56	82	59	126	Domain	Note=Histone-fold;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF12	Q16514	56	82	59	126	Domain	Note=Histone-fold;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF12	Q16514	56	82	59	59	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
TAF12	Q16514	56	82	59	59	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
TAF12	Q16514	56	82	60	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H3O
TAF12	Q16514	56	82	60	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H3O
TAF12	Q16514	56	82	78	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H3O
TAF12	Q16514	56	82	78	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H3O
TAOK3	Q9H2K8	713	784	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	522	565	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	443	522	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	398	443	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	273	329	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	64	98	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	40	64	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	713	784	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	522	565	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	443	522	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	398	443	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	273	329	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	64	98	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	40	64	1	898	Chain	ID=PRO_0000086737;Note=Serine/threonine-protein kinase TAO3
TAOK3	Q9H2K8	273	329	24	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	64	98	24	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	40	64	24	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	273	329	24	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	64	98	24	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	40	64	24	277	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	443	522	452	502	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK3	Q9H2K8	443	522	452	502	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK3	Q9H2K8	522	565	548	649	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK3	Q9H2K8	522	565	548	649	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK3	Q9H2K8	713	784	754	879	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK3	Q9H2K8	713	784	754	879	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK3	Q9H2K8	40	64	53	53	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	40	64	53	53	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK3	Q9H2K8	273	329	324	324	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:17396146;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:20068231,PMID:21406692,PMID:23186163,PMID:17396146
TAOK3	Q9H2K8	273	329	324	324	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:17396146;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:20068231,PMID:21406692,PMID:23186163,PMID:17396146
TAOK3	Q9H2K8	398	443	442	442	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TAOK3	Q9H2K8	398	443	442	442	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TAOK3	Q9H2K8	40	64	47	47	Natural variant	ID=VAR_023691;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:13679851,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.4;Dbxref=dbSNP:rs428073,PMID:13679851,PMID:17344846
TAOK3	Q9H2K8	40	64	47	47	Natural variant	ID=VAR_023691;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:13679851,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.4;Dbxref=dbSNP:rs428073,PMID:13679851,PMID:17344846
TAOK3	Q9H2K8	713	784	727	727	Natural variant	ID=VAR_041207;Note=C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55857273,PMID:17344846
TAOK3	Q9H2K8	713	784	727	727	Natural variant	ID=VAR_041207;Note=C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55857273,PMID:17344846
TAOK3	Q9H2K8	273	329	324	324	Mutagenesis	Note=Inhibits activation of the p38/MAPK14 stress-activated MAPK cascade in response to DNA damage. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17396146;Dbxref=PMID:17396146
TAOK3	Q9H2K8	273	329	324	324	Mutagenesis	Note=Inhibits activation of the p38/MAPK14 stress-activated MAPK cascade in response to DNA damage. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17396146;Dbxref=PMID:17396146
TCN1	P20061	133	185	24	433	Chain	ID=PRO_0000005561;Note=Transcobalamin-1
TCN1	P20061	26	86	24	433	Chain	ID=PRO_0000005561;Note=Transcobalamin-1
TCN1	P20061	133	185	24	310	Region	Note=Globular N-terminal alpha domain
TCN1	P20061	26	86	24	310	Region	Note=Globular N-terminal alpha domain
TCN1	P20061	133	185	142	146	Region	Note=Cobalamin binding
TCN1	P20061	133	185	182	186	Region	Note=Cobalamin binding
TCN1	P20061	133	185	160	160	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TCN1	P20061	133	185	26	265	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23846701;Dbxref=PMID:23846701
TCN1	P20061	26	86	26	265	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23846701;Dbxref=PMID:23846701
TCN1	P20061	133	185	105	308	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23846701;Dbxref=PMID:23846701
TCN1	P20061	133	185	155	197	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23846701;Dbxref=PMID:23846701
TCN1	P20061	26	86	35	35	Natural variant	ID=VAR_031923;Note=R->H;Dbxref=dbSNP:rs34528912
TCN1	P20061	26	86	30	36	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	26	86	37	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	26	86	46	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	26	86	50	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKJ
TCN1	P20061	26	86	55	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	26	86	69	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	133	185	118	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	133	185	136	138	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	133	185	144	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	133	185	163	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	133	185	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCN1	P20061	133	185	185	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KKI
TCERG1L	Q5VWI1	223	285	1	586	Chain	ID=PRO_0000312872;Note=Transcription elongation regulator 1-like protein
TCERG1L	Q5VWI1	223	285	237	247	Compositional bias	Note=Poly-Ala
TENM2	Q9NT68	395	436	1	2774	Chain	ID=PRO_0000259501;Note=Teneurin-2
TENM2	Q9NT68	570	604	1	2774	Chain	ID=PRO_0000259501;Note=Teneurin-2
TENM2	Q9NT68	736	807	1	2774	Chain	ID=PRO_0000259501;Note=Teneurin-2
TENM2	Q9NT68	570	604	529	2774	Chain	ID=PRO_0000421012;Note=Ten-2%2C soluble form;Ontology_term=ECO:0000250;evidence=ECO:0000250
TENM2	Q9NT68	736	807	529	2774	Chain	ID=PRO_0000421012;Note=Ten-2%2C soluble form;Ontology_term=ECO:0000250;evidence=ECO:0000250
TENM2	Q9NT68	395	436	380	400	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM2	Q9NT68	395	436	401	2774	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM2	Q9NT68	570	604	401	2774	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM2	Q9NT68	736	807	401	2774	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM2	Q9NT68	570	604	575	603	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	570	604	598	634	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	738	766	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	769	797	Domain	Note=EGF-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	570	604	576	586	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	570	604	580	591	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	570	604	593	602	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	739	749	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	743	754	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	756	765	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	770	780	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	774	785	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	787	796	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM2	Q9NT68	736	807	799	807	Alternative sequence	ID=VSP_045021;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TENM3	Q9P273	77	170	1	2699	Chain	ID=PRO_0000259505;Note=Teneurin-3
TENM3	Q9P273	546	611	1	2699	Chain	ID=PRO_0000259505;Note=Teneurin-3
TENM3	Q9P273	1768	1867	1	2699	Chain	ID=PRO_0000259505;Note=Teneurin-3
TENM3	Q9P273	77	170	1	310	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM3	Q9P273	546	611	332	2699	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM3	Q9P273	1768	1867	332	2699	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM3	Q9P273	77	170	1	309	Domain	Note=Teneurin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00694
TENM3	Q9P273	546	611	546	576	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	546	611	578	610	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	546	611	611	642	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	1768	1867	1823	1842	Repeat	Note=YD 5
TENM3	Q9P273	1768	1867	1864	1882	Repeat	Note=YD 6
TENM3	Q9P273	1768	1867	1820	1820	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM3	Q9P273	546	611	553	564	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	546	611	566	575	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	546	611	582	593	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	546	611	587	598	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TENM3	Q9P273	546	611	600	609	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
GTF2A1	P52655	311	341	2	376	Chain	ID=PRO_0000022481;Note=Transcription initiation factor IIA subunit 1
GTF2A1	P52655	311	341	275	376	Chain	ID=PRO_0000042594;Note=Transcription initiation factor IIA beta chain
GTF2A1	P52655	311	341	316	316	Modified residue	Note=Phosphoserine%3B by TAF1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000269|PubMed:11278496;Dbxref=PMID:17081983,PMID:11278496
GTF2A1	P52655	311	341	321	321	Modified residue	Note=Phosphoserine%3B by TAF1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000269|PubMed:11278496;Dbxref=PMID:17081983,PMID:11278496
GTF2A1	P52655	311	341	316	316	Mutagenesis	Note=Strongly reduces phosphorylation%3B when associated with A-321. Eliminates phosphorylation%3B when associated with A-280%3B A-281 and A-321. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278496;Dbxref=PMID:11278496
GTF2A1	P52655	311	341	321	321	Mutagenesis	Note=Strongly reduces phosphorylation%3B when associated with A-316. Eliminates phosphorylation%3B when associated with A-280%3B A-281 and A-316. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11278496;Dbxref=PMID:11278496
GTF2A1	P52655	311	341	334	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NVP
GTF2A1L	Q9UNN4	7	41	1	478	Chain	ID=PRO_0000072495;Note=TFIIA-alpha and beta-like factor
GTF2A1L	Q9UNN4	7	41	8	41	Alternative sequence	ID=VSP_040935;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TGFBR3	Q03167	762	776	21	851	Chain	ID=PRO_0000041663;Note=Transforming growth factor beta receptor type 3
TGFBR3	Q03167	569	622	21	851	Chain	ID=PRO_0000041663;Note=Transforming growth factor beta receptor type 3
TGFBR3	Q03167	82	128	21	851	Chain	ID=PRO_0000041663;Note=Transforming growth factor beta receptor type 3
TGFBR3	Q03167	762	776	21	851	Chain	ID=PRO_0000041663;Note=Transforming growth factor beta receptor type 3
TGFBR3	Q03167	569	622	21	851	Chain	ID=PRO_0000041663;Note=Transforming growth factor beta receptor type 3
TGFBR3	Q03167	82	128	21	851	Chain	ID=PRO_0000041663;Note=Transforming growth factor beta receptor type 3
TGFBR3	Q03167	762	776	21	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	569	622	21	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	82	128	21	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	762	776	21	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	569	622	21	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	82	128	21	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	569	622	455	730	Domain	Note=ZP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00375
TGFBR3	Q03167	569	622	455	730	Domain	Note=ZP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00375
TGFBR3	Q03167	569	622	571	571	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	569	622	571	571	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	569	622	590	590	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	569	622	590	590	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR3	Q03167	762	776	765	765	Natural variant	ID=VAR_020894;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs17882828
TGFBR3	Q03167	762	776	765	765	Natural variant	ID=VAR_020894;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs17882828
TGFBR3	Q03167	82	128	89	89	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TGFBR3	Q03167	82	128	89	89	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP5L	Q9Y2K9	703	727	1	1186	Chain	ID=PRO_0000051247;Note=Syntaxin-binding protein 5-like
STXBP5L	Q9Y2K9	703	727	643	705	Repeat	Note=WD 10
STXBP5L	Q9Y2K9	703	727	709	709	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5DQR4
STXBP5L	Q9Y2K9	703	727	75	1186	Alternative sequence	ID=VSP_016294;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STMN1	P16949	62	126	2	149	Chain	ID=PRO_0000182389;Note=Stathmin
STMN1	P16949	62	126	2	149	Chain	ID=PRO_0000182389;Note=Stathmin
STMN1	P16949	62	126	2	149	Chain	ID=PRO_0000182389;Note=Stathmin
STMN1	P16949	62	126	2	149	Chain	ID=PRO_0000182389;Note=Stathmin
STMN1	P16949	62	126	4	145	Domain	Note=SLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00998
STMN1	P16949	62	126	4	145	Domain	Note=SLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00998
STMN1	P16949	62	126	4	145	Domain	Note=SLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00998
STMN1	P16949	62	126	4	145	Domain	Note=SLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00998
STMN1	P16949	62	126	41	140	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STMN1	P16949	62	126	41	140	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STMN1	P16949	62	126	41	140	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STMN1	P16949	62	126	41	140	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STMN1	P16949	62	126	63	63	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:17924679,PMID:20068231,PMID:21406692,PMID:23186163
STMN1	P16949	62	126	63	63	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:17924679,PMID:20068231,PMID:21406692,PMID:23186163
STMN1	P16949	62	126	63	63	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:17924679,PMID:20068231,PMID:21406692,PMID:23186163
STMN1	P16949	62	126	63	63	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:17924679,PMID:20068231,PMID:21406692,PMID:23186163
STMN1	P16949	62	126	100	100	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	100	100	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	100	100	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	100	100	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STMN1	P16949	62	126	119	119	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STRN	O43815	695	724	1	780	Chain	ID=PRO_0000051232;Note=Striatin
STRN	O43815	612	659	1	780	Chain	ID=PRO_0000051232;Note=Striatin
STRN	O43815	500	515	1	780	Chain	ID=PRO_0000051232;Note=Striatin
STRN	O43815	310	347	1	780	Chain	ID=PRO_0000051232;Note=Striatin
STRN	O43815	500	515	461	500	Repeat	Note=WD 1
STRN	O43815	500	515	514	553	Repeat	Note=WD 2
STRN	O43815	695	724	662	701	Repeat	Note=WD 4
STRN	O43815	695	724	704	743	Repeat	Note=WD 5
STRN	O43815	310	347	311	348	Alternative sequence	ID=VSP_023496;Note=In isoform 2. EKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STRAP	Q9Y3F4	167	212	1	350	Chain	ID=PRO_0000051230;Note=Serine-threonine kinase receptor-associated protein
STRAP	Q9Y3F4	308	330	1	350	Chain	ID=PRO_0000051230;Note=Serine-threonine kinase receptor-associated protein
STRAP	Q9Y3F4	167	212	141	179	Repeat	Note=WD 4
STRAP	Q9Y3F4	167	212	180	212	Repeat	Note=WD 5
STRAP	Q9Y3F4	308	330	312	312	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
STOML2	Q9UJZ1	268	311	29	356	Chain	ID=PRO_0000094031;Note=Stomatin-like protein 2%2C mitochondrial
STOML2	Q9UJZ1	148	193	29	356	Chain	ID=PRO_0000094031;Note=Stomatin-like protein 2%2C mitochondrial
STOML2	Q9UJZ1	148	193	149	193	Alternative sequence	ID=VSP_054651;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STX6	O43752	100	121	2	255	Chain	ID=PRO_0000210208;Note=Syntaxin-6
STX6	O43752	100	121	2	234	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX6	O43752	100	121	1	101	Alternative sequence	ID=VSP_054763;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STX6	O43752	100	121	82	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J2C
SUCO	Q9UBS9	59	96	30	1254	Chain	ID=PRO_5000065707;Note=SUN domain-containing ossification factor
SUCO	Q9UBS9	148	193	30	1254	Chain	ID=PRO_5000065707;Note=SUN domain-containing ossification factor
SUCO	Q9UBS9	350	385	30	1254	Chain	ID=PRO_5000065707;Note=SUN domain-containing ossification factor
SUCO	Q9UBS9	499	522	30	1254	Chain	ID=PRO_5000065707;Note=SUN domain-containing ossification factor
SUCO	Q9UBS9	971	1006	30	1254	Chain	ID=PRO_5000065707;Note=SUN domain-containing ossification factor
SUCO	Q9UBS9	350	385	284	453	Domain	Note=SUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00802
SUCO	Q9UBS9	971	1006	909	1009	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SUCO	Q9UBS9	59	96	60	96	Alternative sequence	ID=VSP_027922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SUMO1	P63165	55	79	2	97	Chain	ID=PRO_0000035939;Note=Small ubiquitin-related modifier 1
SUMO1	P63165	29	55	2	97	Chain	ID=PRO_0000035939;Note=Small ubiquitin-related modifier 1
SUMO1	P63165	4	29	2	97	Chain	ID=PRO_0000035939;Note=Small ubiquitin-related modifier 1
SUMO1	P63165	55	79	2	97	Chain	ID=PRO_0000035939;Note=Small ubiquitin-related modifier 1
SUMO1	P63165	29	55	2	97	Chain	ID=PRO_0000035939;Note=Small ubiquitin-related modifier 1
SUMO1	P63165	55	79	20	97	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO1	P63165	29	55	20	97	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO1	P63165	4	29	20	97	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO1	P63165	55	79	20	97	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO1	P63165	29	55	20	97	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO1	P63165	29	55	36	36	Site	Note=Interaction with PIAS2
SUMO1	P63165	29	55	36	36	Site	Note=Interaction with PIAS2
SUMO1	P63165	4	29	9	9	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
SUMO1	P63165	29	55	32	32	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUMO1	P63165	29	55	32	32	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUMO1	P63165	4	29	7	7	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate
SUMO1	P63165	4	29	7	7	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
SUMO1	P63165	4	29	16	16	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
SUMO1	P63165	4	29	17	17	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
SUMO1	P63165	4	29	23	23	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	4	29	25	25	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
SUMO1	P63165	29	55	37	37	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
SUMO1	P63165	29	55	37	37	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
SUMO1	P63165	29	55	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	29	55	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	29	55	45	45	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	29	55	45	45	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	29	55	46	46	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	29	55	46	46	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SUMO1	P63165	4	29	4	28	Alternative sequence	ID=VSP_046756;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUMO1	P63165	29	55	36	36	Mutagenesis	Note=Abolishes binding to PIAS2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16204249;Dbxref=PMID:16204249
SUMO1	P63165	29	55	36	36	Mutagenesis	Note=Abolishes binding to PIAS2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16204249;Dbxref=PMID:16204249
SUMO1	P63165	55	79	75	75	Sequence conflict	Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUMO1	P63165	55	79	75	75	Sequence conflict	Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUMO1	P63165	4	29	2	6	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A5R
SUMO1	P63165	4	29	9	11	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A5R
SUMO1	P63165	4	29	16	18	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KQS
SUMO1	P63165	4	29	22	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	29	55	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z5S
SUMO1	P63165	4	29	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z5S
SUMO1	P63165	29	55	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z5S
SUMO1	P63165	29	55	33	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	29	55	33	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	29	55	40	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
SUMO1	P63165	29	55	40	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
SUMO1	P63165	55	79	45	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	29	55	45	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	45	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	29	55	45	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	59	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	59	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	62	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	62	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B7A
SUMO1	P63165	55	79	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5B7A
SUMO1	P63165	55	79	77	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUMO1	P63165	55	79	77	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJQ
SUPT3H	O75486	267	304	1	317	Chain	ID=PRO_0000072313;Note=Transcription initiation protein SPT3 homolog
SUPT3H	O75486	0	33	1	317	Chain	ID=PRO_0000072313;Note=Transcription initiation protein SPT3 homolog
SUPT3H	O75486	0	33	1	1	Modified residue	Note=N-acetylmethionine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
SUPT3H	O75486	0	33	1	34	Alternative sequence	ID=VSP_059496;Note=In isoform 2. MNNTAASPMSTATSSSGRSTGKSISFATELQSMM->MVVFGTTFFNFDSFIGKTDSIEIIGKSVFPYCYHNILPLLNDSGR
SURF2	Q15527	112	172	1	256	Chain	ID=PRO_0000072319;Note=Surfeit locus protein 2
SURF2	Q15527	112	172	142	143	Sequence conflict	Note=DG->EA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SURF2	Q15527	112	172	160	160	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SVIL	O95425	1251	1280	1	2214	Chain	ID=PRO_0000218740;Note=Supervillin
SVIL	O95425	749	780	1	2214	Chain	ID=PRO_0000218740;Note=Supervillin
SVIL	O95425	613	669	1	2214	Chain	ID=PRO_0000218740;Note=Supervillin
SVIL	O95425	303	612	1	2214	Chain	ID=PRO_0000218740;Note=Supervillin
SVIL	O95425	276	302	1	2214	Chain	ID=PRO_0000218740;Note=Supervillin
SVIL	O95425	303	612	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K4L3
SVIL	O95425	749	780	769	769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SVIL	O95425	613	669	276	669	Alternative sequence	ID=VSP_012425;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9867483;Dbxref=PMID:9867483
SVIL	O95425	303	612	276	669	Alternative sequence	ID=VSP_012425;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9867483;Dbxref=PMID:9867483
SVIL	O95425	276	302	276	669	Alternative sequence	ID=VSP_012425;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9867483;Dbxref=PMID:9867483
SVIL	O95425	276	302	276	302	Alternative sequence	ID=VSP_053768;Note=In isoform SV3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SVIL	O95425	749	780	750	781	Alternative sequence	ID=VSP_012426;Note=In isoform 2 and isoform SV4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:23382381,ECO:0000303|PubMed:9867483;Dbxref=PMID:23382381,PMID:9867483
SVIL	O95425	303	612	422	422	Natural variant	ID=VAR_058308;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12711699,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1247696,PMID:12711699
SV2B	Q7L1I2	502	569	1	683	Chain	ID=PRO_0000239768;Note=Synaptic vesicle glycoprotein 2B
SV2B	Q7L1I2	502	569	1	683	Chain	ID=PRO_0000239768;Note=Synaptic vesicle glycoprotein 2B
SV2B	Q7L1I2	502	569	412	535	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	412	535	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	536	556	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	536	556	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	557	565	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	557	565	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	566	586	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	566	586	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	516	516	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SV2B	Q7L1I2	502	569	516	516	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
XAB2	Q9HCS7	657	698	1	855	Chain	ID=PRO_0000106414;Note=Pre-mRNA-splicing factor SYF1
XAB2	Q9HCS7	174	219	1	855	Chain	ID=PRO_0000106414;Note=Pre-mRNA-splicing factor SYF1
XAB2	Q9HCS7	174	219	160	192	Repeat	Note=HAT 5;Ontology_term=ECO:0000305;evidence=ECO:0000305
XAB2	Q9HCS7	174	219	198	230	Repeat	Note=HAT 6
XAB2	Q9HCS7	657	698	643	677	Repeat	Note=HAT 13
XAB2	Q9HCS7	657	698	679	713	Repeat	Note=HAT 14
XAB2	Q9HCS7	657	698	680	680	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
FARS2	O95363	257	301	287	287	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18611382,ECO:0000269|PubMed:19549855;Dbxref=PMID:18611382,PMID:19549855
FARS2	O95363	257	301	287	287	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18611382,ECO:0000269|PubMed:19549855;Dbxref=PMID:18611382,PMID:19549855
FARS2	O95363	257	301	280	280	Natural variant	ID=VAR_052643;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3,ECO:0000269|Ref.7;Dbxref=dbSNP:rs11243011,PMID:14702039
FARS2	O95363	257	301	280	280	Natural variant	ID=VAR_052643;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3,ECO:0000269|Ref.7;Dbxref=dbSNP:rs11243011,PMID:14702039
FARS2	O95363	257	301	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HFV
FARS2	O95363	257	301	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HFV
FARS2	O95363	257	301	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	271	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	271	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	284	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	284	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	296	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	296	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
MARS	P56192	93	138	1	900	Chain	ID=PRO_0000139262;Note=Methionine--tRNA ligase%2C cytoplasmic
MARS	P56192	257	295	1	900	Chain	ID=PRO_0000139262;Note=Methionine--tRNA ligase%2C cytoplasmic
MARS	P56192	431	456	1	900	Chain	ID=PRO_0000139262;Note=Methionine--tRNA ligase%2C cytoplasmic
MARS	P56192	513	545	1	900	Chain	ID=PRO_0000139262;Note=Methionine--tRNA ligase%2C cytoplasmic
MARS	P56192	656	699	1	900	Chain	ID=PRO_0000139262;Note=Methionine--tRNA ligase%2C cytoplasmic
MARS	P56192	821	852	1	900	Chain	ID=PRO_0000139262;Note=Methionine--tRNA ligase%2C cytoplasmic
MARS	P56192	93	138	74	198	Domain	Note=GST C-terminal
MARS	P56192	821	852	841	897	Domain	Note=WHEP-TRS
MARS	P56192	257	295	273	283	Motif	Note="HIGH" region
MARS	P56192	821	852	825	825	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FL6
MARS	P56192	821	852	835	835	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FL6
MARS	P56192	656	699	547	900	Alternative sequence	ID=VSP_056564;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MARS	P56192	821	852	547	900	Alternative sequence	ID=VSP_056564;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MARS	P56192	513	545	523	523	Natural variant	ID=VAR_070873;Note=In ILLD. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24103465;Dbxref=dbSNP:rs201555303,PMID:24103465
MARS	P56192	656	699	683	683	Natural variant	ID=VAR_020459;Note=A->D;Dbxref=dbSNP:rs1054403
MARS	P56192	93	138	99	99	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARS	P56192	656	699	683	683	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARS	P56192	656	699	683	683	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
MARS	P56192	93	138	92	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BVX
MARS	P56192	93	138	111	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BVX
MARS	P56192	93	138	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BVX
MARS	P56192	93	138	118	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BVX
MARS	P56192	93	138	131	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BVX
MARS	P56192	257	295	265	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	257	295	281	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	257	295	288	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	431	456	431	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	431	456	436	438	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	431	456	443	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	431	456	454	468	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	513	545	517	520	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	513	545	521	523	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	513	545	524	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	513	545	534	536	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	513	545	537	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	513	545	543	545	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	656	699	650	664	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	656	699	676	696	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	656	699	697	699	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GL7
MARS	P56192	821	852	838	861	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJV
TRAFD1	O14545	214	283	2	582	Chain	ID=PRO_0000278457;Note=TRAF-type zinc finger domain-containing protein 1
TRAFD1	O14545	309	386	2	582	Chain	ID=PRO_0000278457;Note=TRAF-type zinc finger domain-containing protein 1
TRAFD1	O14545	214	283	2	582	Chain	ID=PRO_0000278457;Note=TRAF-type zinc finger domain-containing protein 1
TRAFD1	O14545	309	386	2	582	Chain	ID=PRO_0000278457;Note=TRAF-type zinc finger domain-containing protein 1
TRAFD1	O14545	214	283	278	278	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRAFD1	O14545	214	283	278	278	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRAFD1	O14545	309	386	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TRAFD1	O14545	309	386	320	320	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TRAFD1	O14545	309	386	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
TRAFD1	O14545	309	386	326	326	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
TRAFD1	O14545	309	386	327	327	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TRAFD1	O14545	309	386	327	327	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TRAFD1	O14545	214	283	165	582	Alternative sequence	ID=VSP_056086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAFD1	O14545	309	386	165	582	Alternative sequence	ID=VSP_056086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAFD1	O14545	214	283	165	582	Alternative sequence	ID=VSP_056086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAFD1	O14545	309	386	165	582	Alternative sequence	ID=VSP_056086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF4	Q9BUZ4	65	100	1	470	Chain	ID=PRO_0000056403;Note=TNF receptor-associated factor 4
TRAF4	Q9BUZ4	100	154	1	470	Chain	ID=PRO_0000056403;Note=TNF receptor-associated factor 4
TRAF4	Q9BUZ4	100	154	102	154	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF4	Q9BUZ4	100	154	123	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUC
TRAF4	Q9BUZ4	100	154	127	132	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUC
TRAF4	Q9BUZ4	100	154	142	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUC
TRAF4	Q9BUZ4	100	154	150	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUC
TRAF5	O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
TRAF5	O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF5	O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF5	O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF5	O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF5	O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF5	O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF5	O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAF5	O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAF5	O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
TRAF5	O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
TRAF5	O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
TRAF5	O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
TRAF5	O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
TRAF5	O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
TRAF6	Q9Y4K3	226	252	1	522	Chain	ID=PRO_0000056407;Note=TNF receptor-associated factor 6
TRAF6	Q9Y4K3	149	202	1	522	Chain	ID=PRO_0000056407;Note=TNF receptor-associated factor 6
TRAF6	Q9Y4K3	226	252	1	522	Chain	ID=PRO_0000056407;Note=TNF receptor-associated factor 6
TRAF6	Q9Y4K3	149	202	1	522	Chain	ID=PRO_0000056407;Note=TNF receptor-associated factor 6
TRAF6	Q9Y4K3	149	202	150	202	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF6	Q9Y4K3	149	202	150	202	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF6	Q9Y4K3	226	252	203	259	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF6	Q9Y4K3	226	252	203	259	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207
TRAF6	Q9Y4K3	226	252	1	354	Region	Note=Interaction with TAX1BP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10920205;Dbxref=PMID:10920205
TRAF6	Q9Y4K3	149	202	1	354	Region	Note=Interaction with TAX1BP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10920205;Dbxref=PMID:10920205
TRAF6	Q9Y4K3	226	252	1	354	Region	Note=Interaction with TAX1BP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10920205;Dbxref=PMID:10920205
TRAF6	Q9Y4K3	149	202	1	354	Region	Note=Interaction with TAX1BP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10920205;Dbxref=PMID:10920205
TRAF6	Q9Y4K3	149	202	149	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCT
TRAF6	Q9Y4K3	149	202	149	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCT
TRAF6	Q9Y4K3	149	202	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCT
TRAF6	Q9Y4K3	149	202	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCT
TRAF6	Q9Y4K3	149	202	158	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	158	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	163	165	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	163	165	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	168	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	168	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	174	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	174	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	186	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	186	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	190	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	190	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	198	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	198	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
TRAF6	Q9Y4K3	149	202	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HCS
SYN1	P17600	327	351	1	705	Chain	ID=PRO_0000183018;Note=Synapsin-1
SYN1	P17600	327	351	113	420	Region	Note=C%3B actin-binding and synaptic-vesicle binding
SYN3	O14994	306	330	1	580	Chain	ID=PRO_0000183024;Note=Synapsin-3
SYN3	O14994	306	330	91	399	Region	Note=C%3B actin-binding and synaptic-vesicle binding
SYN3	O14994	306	330	301	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0A
SYN3	O14994	306	330	318	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0A
SYN3	O14994	306	330	330	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P0A
TRAIP	Q9BWF2	362	412	1	469	Chain	ID=PRO_0000056191;Note=E3 ubiquitin-protein ligase TRAIP
TRAIP	Q9BWF2	295	345	1	469	Chain	ID=PRO_0000056191;Note=E3 ubiquitin-protein ligase TRAIP
TRAIP	Q9BWF2	235	265	1	469	Chain	ID=PRO_0000056191;Note=E3 ubiquitin-protein ligase TRAIP
TRAIP	Q9BWF2	168	205	1	469	Chain	ID=PRO_0000056191;Note=E3 ubiquitin-protein ligase TRAIP
TRAIP	Q9BWF2	362	412	211	469	Region	Note=Interaction with CYLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14676304;Dbxref=PMID:14676304
TRAIP	Q9BWF2	295	345	211	469	Region	Note=Interaction with CYLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14676304;Dbxref=PMID:14676304
TRAIP	Q9BWF2	235	265	211	469	Region	Note=Interaction with CYLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14676304;Dbxref=PMID:14676304
TRAIP	Q9BWF2	168	205	70	177	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAIP	Q9BWF2	235	265	201	280	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAIP	Q9BWF2	168	205	201	280	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAIP	Q9BWF2	295	345	304	304	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TRAIP	Q9BWF2	168	205	177	177	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAK1	Q9UPV9	121	160	1	953	Chain	ID=PRO_0000058037;Note=Trafficking kinesin-binding protein 1
TRAK1	Q9UPV9	300	325	1	953	Chain	ID=PRO_0000058037;Note=Trafficking kinesin-binding protein 1
TRAK1	Q9UPV9	397	475	1	953	Chain	ID=PRO_0000058037;Note=Trafficking kinesin-binding protein 1
TRAK1	Q9UPV9	121	160	47	354	Domain	Note=HAP1 N-terminal
TRAK1	Q9UPV9	300	325	47	354	Domain	Note=HAP1 N-terminal
TRAK1	Q9UPV9	397	475	359	509	Region	Note=Interaction with HGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18675823;Dbxref=PMID:18675823
TRAK1	Q9UPV9	121	160	104	356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAK1	Q9UPV9	300	325	104	356	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAK1	Q9UPV9	397	475	447	447	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24995978;Dbxref=PMID:24995978
TRAK1	Q9UPV9	397	475	447	447	Mutagenesis	Note=Reduced O-glycosylation of this protein. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24995978;Dbxref=PMID:24995978
TRAK2	O60296	325	371	1	914	Chain	ID=PRO_0000064538;Note=Trafficking kinesin-binding protein 2
TRAK2	O60296	300	325	1	914	Chain	ID=PRO_0000064538;Note=Trafficking kinesin-binding protein 2
TRAK2	O60296	325	371	48	353	Domain	Note=HAP1 N-terminal
TRAK2	O60296	300	325	48	353	Domain	Note=HAP1 N-terminal
TRAK2	O60296	325	371	359	509	Region	Note=Interaction with HGS;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAK2	O60296	325	371	134	354	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAK2	O60296	300	325	134	354	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAK2	O60296	300	325	301	311	Alternative sequence	ID=VSP_053418;Note=In isoform 2. HVIEKEELKLH->VGLFIHSTDIC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAK2	O60296	325	371	312	914	Alternative sequence	ID=VSP_053419;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAK2	O60296	300	325	312	914	Alternative sequence	ID=VSP_053419;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SYNE3	Q6ZMZ3	592	637	1	975	Chain	ID=PRO_0000281120;Note=Nesprin-3
SYNE3	Q6ZMZ3	483	544	1	975	Chain	ID=PRO_0000281120;Note=Nesprin-3
SYNE3	Q6ZMZ3	209	263	1	975	Chain	ID=PRO_0000281120;Note=Nesprin-3
SYNE3	Q6ZMZ3	592	637	1	925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00385
SYNE3	Q6ZMZ3	483	544	1	925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00385
SYNE3	Q6ZMZ3	209	263	1	925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00385
SYNE3	Q6ZMZ3	209	263	220	325	Repeat	Note=Spectrin 1
SYNE3	Q6ZMZ3	592	637	617	645	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SYNE3	Q6ZMZ3	592	637	593	596	Alternative sequence	ID=VSP_023976;Note=In isoform 3. GLQE->VRGL;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SYNE3	Q6ZMZ3	592	637	597	975	Alternative sequence	ID=VSP_023977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SYNJ2	O15056	237	265	1	1496	Chain	ID=PRO_0000209733;Note=Synaptojanin-2
SYNJ2	O15056	1069	1114	1	1496	Chain	ID=PRO_0000209733;Note=Synaptojanin-2
SYNJ2	O15056	237	265	120	444	Domain	Note=SAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00183
SYNJ2	O15056	1069	1114	1099	1114	Compositional bias	Note=Pro-rich
SYNJ2	O15056	1069	1114	1070	1114	Alternative sequence	ID=VSP_012911;Note=In isoform 2B1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TASP1	Q9H6P5	71	94	1	233	Chain	ID=PRO_0000002350;Note=Threonine aspartase subunit alpha
TASP1	Q9H6P5	328	365	234	420	Chain	ID=PRO_0000002351;Note=Threonine aspartase subunit beta
TASP1	Q9H6P5	291	328	234	420	Chain	ID=PRO_0000002351;Note=Threonine aspartase subunit beta
TASP1	Q9H6P5	328	365	130	420	Alternative sequence	ID=VSP_056328;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TASP1	Q9H6P5	291	328	130	420	Alternative sequence	ID=VSP_056328;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TASP1	Q9H6P5	328	365	146	420	Alternative sequence	ID=VSP_056534;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TASP1	Q9H6P5	291	328	146	420	Alternative sequence	ID=VSP_056534;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TASP1	Q9H6P5	328	365	357	357	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TASP1	Q9H6P5	71	94	57	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	71	94	82	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	291	328	282	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	291	328	294	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	291	328	302	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	291	328	315	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	328	365	326	329	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	291	328	326	329	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	328	365	331	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	328	365	341	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
TASP1	Q9H6P5	328	365	365	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A8J
RSPO1	Q2MKA7	145	208	21	263	Chain	ID=PRO_0000234436;Note=R-spondin-1
RSPO1	Q2MKA7	145	208	21	263	Chain	ID=PRO_0000234436;Note=R-spondin-1
RSPO1	Q2MKA7	145	208	147	207	Domain	Note=TSP type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	147	207	Domain	Note=TSP type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	148	190	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	148	190	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	159	166	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	159	166	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	199	206	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	199	206	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
RSPO1	Q2MKA7	145	208	146	208	Alternative sequence	ID=VSP_043265;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17041600;Dbxref=PMID:17041600
RSPO1	Q2MKA7	145	208	146	208	Alternative sequence	ID=VSP_043265;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17041600;Dbxref=PMID:17041600
RSPO1	Q2MKA7	145	208	150	150	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
RSPO1	Q2MKA7	145	208	150	150	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPS10	P82664	144	174	1	201	Chain	ID=PRO_0000146675;Note=28S ribosomal protein S10%2C mitochondrial
MRPS18A	Q9NVS2	48	84	35	196	Chain	ID=PRO_0000030625;Note=39S ribosomal protein S18a%2C mitochondrial
MRPS18A	Q9NVS2	48	84	48	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS18A	Q9NVS2	48	84	73	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS31	Q92665	51	146	1	65	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRPS31	Q92665	147	199	66	395	Chain	ID=PRO_0000030594;Note=28S ribosomal protein S31%2C mitochondrial
MRPS31	Q92665	51	146	66	395	Chain	ID=PRO_0000030594;Note=28S ribosomal protein S31%2C mitochondrial
MRPS31	Q92665	51	146	80	80	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPS31	Q92665	51	146	132	132	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC14L6	B5MCN3	141	173	1	397	Chain	ID=PRO_0000410725;Note=Putative SEC14-like protein 6
SEC14L6	B5MCN3	78	141	1	397	Chain	ID=PRO_0000410725;Note=Putative SEC14-like protein 6
SEC14L6	B5MCN3	141	173	76	249	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
SEC14L6	B5MCN3	78	141	76	249	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
SLC15A1	P46059	609	645	1	708	Chain	ID=PRO_0000064304;Note=Solute carrier family 15 member 1
SLC15A1	P46059	270	300	1	708	Chain	ID=PRO_0000064304;Note=Solute carrier family 15 member 1
SLC15A1	P46059	270	300	220	276	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A1	P46059	270	300	277	297	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A1	P46059	270	300	298	327	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A1	P46059	609	645	606	619	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A1	P46059	609	645	620	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC15A1	P46059	609	645	641	645	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TESPA1	A2RU30	116	148	1	521	Chain	ID=PRO_0000315219;Note=Protein TESPA1
TESPA1	A2RU30	116	148	1	521	Chain	ID=PRO_0000315219;Note=Protein TESPA1
TESPA1	A2RU30	116	148	1	138	Alternative sequence	ID=VSP_030488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9872452;Dbxref=PMID:14702039,PMID:15489334,PMID:9872452
TESPA1	A2RU30	116	148	1	138	Alternative sequence	ID=VSP_030488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9872452;Dbxref=PMID:14702039,PMID:15489334,PMID:9872452
SLC13A1	Q9BZW2	344	377	1	595	Chain	ID=PRO_0000172485;Note=Solute carrier family 13 member 1
SLC13A1	Q9BZW2	344	377	348	368	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	1	542	Chain	ID=PRO_0000273439;Note=Solute carrier family 22 member 8
SLC22A8	Q8TCC7	442	509	1	542	Chain	ID=PRO_0000273439;Note=Solute carrier family 22 member 8
SLC22A8	Q8TCC7	442	509	433	471	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	433	471	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	472	492	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	472	492	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	493	542	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	493	542	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC22A8	Q8TCC7	442	509	406	455	Alternative sequence	ID=VSP_022563;Note=In isoform 3. DLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRV->GERLGLPQNPLEEAARLGARDFTAGSASKSLCYLEQVPALSGAQGLSSRK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SLC22A8	Q8TCC7	442	509	406	455	Alternative sequence	ID=VSP_022563;Note=In isoform 3. DLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRV->GERLGLPQNPLEEAARLGARDFTAGSASKSLCYLEQVPALSGAQGLSSRK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SLC22A8	Q8TCC7	442	509	456	542	Alternative sequence	ID=VSP_022564;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SLC22A8	Q8TCC7	442	509	456	542	Alternative sequence	ID=VSP_022564;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SLC22A8	Q8TCC7	442	509	448	448	Natural variant	ID=VAR_030153;Note=V->I;Dbxref=dbSNP:rs11568486
SLC22A8	Q8TCC7	442	509	448	448	Natural variant	ID=VAR_030153;Note=V->I;Dbxref=dbSNP:rs11568486
SLC22A8	Q8TCC7	442	509	478	480	Sequence conflict	Note=YGI->FTGS;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC22A8	Q8TCC7	442	509	478	480	Sequence conflict	Note=YGI->FTGS;Ontology_term=ECO:0000305;evidence=ECO:0000305
TES	Q9UGI8	234	306	1	421	Chain	ID=PRO_0000075906;Note=Testin
TES	Q9UGI8	306	359	1	421	Chain	ID=PRO_0000075906;Note=Testin
TES	Q9UGI8	234	306	234	297	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
TES	Q9UGI8	234	306	299	359	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
TES	Q9UGI8	306	359	299	359	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
TES	Q9UGI8	306	359	328	328	Mutagenesis	Note=Abolishes interaction with ACTL7A. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21278383;Dbxref=PMID:21278383
TES	Q9UGI8	234	306	302	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	234	306	305	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	305	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	313	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	323	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	329	331	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	338	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	346	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
TES	Q9UGI8	306	359	350	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XQN
SLC25A33	Q9BSK2	79	104	1	321	Chain	ID=PRO_0000291785;Note=Solute carrier family 25 member 33
SLC25A33	Q9BSK2	79	104	9	118	Repeat	Note=Solcar 1
SLC25A35	Q3KQZ1	147	198	1	300	Chain	ID=PRO_0000291794;Note=Solute carrier family 25 member 35
SLC25A35	Q3KQZ1	125	147	1	300	Chain	ID=PRO_0000291794;Note=Solute carrier family 25 member 35
SLC25A35	Q3KQZ1	147	198	169	190	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A35	Q3KQZ1	147	198	100	193	Repeat	Note=Solcar 2
SLC25A35	Q3KQZ1	125	147	100	193	Repeat	Note=Solcar 2
SLC38A2	Q96QD8	235	291	1	506	Chain	ID=PRO_0000311369;Note=Sodium-coupled neutral amino acid transporter 2
SLC38A2	Q96QD8	235	291	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A2	Q96QD8	235	291	239	292	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A2	Q96QD8	235	291	258	258	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A2	Q96QD8	235	291	274	274	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A2	Q96QD8	235	291	245	281	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SLC38A2	Q96QD8	235	291	273	273	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	1	606	Chain	ID=PRO_0000320686;Note=Sodium-independent sulfate anion transporter
SLC26A11	Q86WA9	328	345	1	606	Chain	ID=PRO_0000320686;Note=Sodium-independent sulfate anion transporter
SLC26A11	Q86WA9	328	345	1	606	Chain	ID=PRO_0000320686;Note=Sodium-independent sulfate anion transporter
SLC26A11	Q86WA9	328	345	1	606	Chain	ID=PRO_0000320686;Note=Sodium-independent sulfate anion transporter
SLC26A11	Q86WA9	328	345	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	329	341	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	329	341	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	329	341	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	329	341	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A11	Q86WA9	328	345	328	328	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	328	328	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	328	328	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	328	328	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	332	332	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	332	332	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	332	332	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A11	Q86WA9	328	345	332	332	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC35B3	Q9H1N7	260	291	1	401	Chain	ID=PRO_0000213379;Note=Adenosine 3'-phospho 5'-phosphosulfate transporter 2
SLC35B3	Q9H1N7	260	291	267	287	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC35B3	Q9H1N7	260	291	154	401	Alternative sequence	ID=VSP_016194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC35B3	Q9H1N7	260	291	261	283	Alternative sequence	ID=VSP_016195;Note=In isoform 3. VLYSYSIGFVYILLGLTCTSGLG->NITTSSYSGVFIFPNKLKIPLVL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC35B3	Q9H1N7	260	291	284	401	Alternative sequence	ID=VSP_016196;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLC38A6	Q8IZM9	208	230	1	456	Chain	ID=PRO_0000311421;Note=Probable sodium-coupled neutral amino acid transporter 6
SLC38A6	Q8IZM9	230	248	1	456	Chain	ID=PRO_0000311421;Note=Probable sodium-coupled neutral amino acid transporter 6
SLC38A6	Q8IZM9	208	230	191	211	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A6	Q8IZM9	230	248	233	233	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC38A6	Q8IZM9	208	230	218	238	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SLC38A6	Q8IZM9	230	248	218	238	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SLC6A16	Q9GZN6	292	329	1	736	Chain	ID=PRO_0000214801;Note=Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
SLC6A16	Q9GZN6	292	329	290	310	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC6A16	Q9GZN6	292	329	307	307	Sequence conflict	Note=G->GG;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC26A8	Q96RN1	264	314	1	970	Chain	ID=PRO_0000322586;Note=Testis anion transporter 1
SLC26A8	Q96RN1	264	314	1	970	Chain	ID=PRO_0000322586;Note=Testis anion transporter 1
SLC26A8	Q96RN1	264	314	254	270	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	254	270	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	271	291	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	271	291	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	292	307	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	292	307	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	308	328	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC26A8	Q96RN1	264	314	2	419	Alternative sequence	ID=VSP_052704;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14574404;Dbxref=PMID:14574404
SLC26A8	Q96RN1	264	314	2	419	Alternative sequence	ID=VSP_052704;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14574404;Dbxref=PMID:14574404
SLC26A8	Q96RN1	264	314	210	314	Alternative sequence	ID=VSP_052705;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC26A8	Q96RN1	264	314	210	314	Alternative sequence	ID=VSP_052705;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GTF3C2	Q8WUA4	376	451	1	911	Chain	ID=PRO_0000050985;Note=General transcription factor 3C polypeptide 2
GTF3C2	Q8WUA4	317	342	1	911	Chain	ID=PRO_0000050985;Note=General transcription factor 3C polypeptide 2
GTF3C2	Q8WUA4	376	451	1	911	Chain	ID=PRO_0000050985;Note=General transcription factor 3C polypeptide 2
GTF3C2	Q8WUA4	317	342	1	911	Chain	ID=PRO_0000050985;Note=General transcription factor 3C polypeptide 2
GTF3C2	Q8WUA4	376	451	366	426	Repeat	Note=WD 1
GTF3C2	Q8WUA4	376	451	366	426	Repeat	Note=WD 1
GTF3C2	Q8WUA4	376	451	427	483	Repeat	Note=WD 2
GTF3C2	Q8WUA4	376	451	427	483	Repeat	Note=WD 2
GTF3C3	Q9Y5Q9	795	846	2	886	Chain	ID=PRO_0000106363;Note=General transcription factor 3C polypeptide 3
GTF3C3	Q9Y5Q9	795	846	811	844	Repeat	Note=TPR 11
GTF3C3	Q9Y5Q9	795	846	414	886	Alternative sequence	ID=VSP_010354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
GTF3C6	Q969F1	67	82	2	213	Chain	ID=PRO_0000089507;Note=General transcription factor 3C polypeptide 6
GTF3C6	Q969F1	82	120	2	213	Chain	ID=PRO_0000089507;Note=General transcription factor 3C polypeptide 6
SAE1	Q9UBE0	70	128	1	346	Chain	ID=PRO_0000194966;Note=SUMO-activating enzyme subunit 1
SAE1	Q9UBE0	70	128	2	346	Chain	ID=PRO_0000423290;Note=SUMO-activating enzyme subunit 1%2C N-terminally processed
SAE1	Q9UBE0	70	128	115	115	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAE1	Q9UBE0	70	128	73	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYC
SAE1	Q9UBE0	70	128	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
SAE1	Q9UBE0	70	128	91	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
SAE1	Q9UBE0	70	128	106	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
SAE1	Q9UBE0	70	128	115	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
SAE1	Q9UBE0	70	128	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
SAE1	Q9UBE0	70	128	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
SAFB	Q15424	113	182	2	915	Chain	ID=PRO_0000081905;Note=Scaffold attachment factor B1
SAFB	Q15424	431	481	2	915	Chain	ID=PRO_0000081905;Note=Scaffold attachment factor B1
SAFB	Q15424	621	717	2	915	Chain	ID=PRO_0000081905;Note=Scaffold attachment factor B1
SAFB	Q15424	431	481	406	484	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SAFB	Q15424	621	717	528	792	Region	Note=Interaction with POLR2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671816;Dbxref=PMID:9671816
SAFB	Q15424	621	717	599	915	Region	Note=Interaction with SAFB2
SAFB	Q15424	621	717	612	831	Compositional bias	Note=Arg-rich
SAFB	Q15424	621	717	625	705	Compositional bias	Note=Glu-rich
SAFB	Q15424	113	182	172	172	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
SAFB	Q15424	113	182	114	182	Alternative sequence	ID=VSP_045838;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SAFB	Q15424	621	717	621	621	Alternative sequence	ID=VSP_046902;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334
SAFB	Q15424	431	481	463	463	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAFB	Q15424	621	717	692	692	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AHCYL1	O43865	439	462	2	530	Chain	ID=PRO_0000116908;Note=S-adenosylhomocysteine hydrolase-like protein 1
AHCYL1	O43865	439	462	281	448	Region	Note=NAD binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
AHCYL1	O43865	439	462	438	440	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MTG
AHCYL1	O43865	439	462	444	446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MTG
AHCYL1	O43865	439	462	452	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MTG
TCF3	P15923	389	442	1	654	Chain	ID=PRO_0000127466;Note=Transcription factor E2-alpha
TCF3	P15923	389	442	389	425	Region	Note=Leucine-zipper
TCF3	P15923	389	442	431	431	Natural variant	ID=VAR_049554;Note=G->S;Dbxref=dbSNP:rs1052692
TCF3	P15923	389	442	390	390	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD8	Q96LT4	193	224	1	415	Chain	ID=PRO_0000221080;Note=Sphingomyelin synthase-related protein 1
SAMD8	Q96LT4	193	224	201	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SAMSN1	Q9NSI8	43	93	1	373	Chain	ID=PRO_0000097574;Note=SAM domain-containing protein SAMSN-1
SAMSN1	Q9NSI8	43	93	74	74	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMSN1	Q9NSI8	43	93	76	76	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMSN1	Q9NSI8	43	93	90	90	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMSN1	Q9NSI8	43	93	19	186	Alternative sequence	ID=VSP_008119;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SAMSN1	Q9NSI8	43	93	63	63	Natural variant	ID=VAR_051331;Note=G->A;Dbxref=dbSNP:rs34607574
TFEB	P19484	71	156	1	476	Chain	ID=PRO_0000127473;Note=Transcription factor EB
TFEB	P19484	71	156	1	476	Chain	ID=PRO_0000127473;Note=Transcription factor EB
TFEB	P19484	71	156	1	476	Chain	ID=PRO_0000127473;Note=Transcription factor EB
TFEB	P19484	71	156	156	165	Region	Note=Strong transcription activation domain;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFEB	P19484	71	156	156	165	Region	Note=Strong transcription activation domain;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFEB	P19484	71	156	156	165	Region	Note=Strong transcription activation domain;Ontology_term=ECO:0000255;evidence=ECO:0000255
TFEB	P19484	71	156	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R210
TFEB	P19484	71	156	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R210
TFEB	P19484	71	156	109	109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R210
TFEB	P19484	71	156	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R210
TFEB	P19484	71	156	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R210
TFEB	P19484	71	156	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R210
TFEB	P19484	71	156	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TFEB	P19484	71	156	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TFEB	P19484	71	156	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TFEB	P19484	71	156	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TFEB	P19484	71	156	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TFEB	P19484	71	156	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TFEB	P19484	71	156	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TFEB	P19484	71	156	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TFEB	P19484	71	156	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TFEB	P19484	71	156	72	156	Alternative sequence	ID=VSP_002159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2115126;Dbxref=PMID:15489334,PMID:2115126
TFEB	P19484	71	156	72	156	Alternative sequence	ID=VSP_002159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2115126;Dbxref=PMID:15489334,PMID:2115126
TFEB	P19484	71	156	72	156	Alternative sequence	ID=VSP_002159;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2115126;Dbxref=PMID:15489334,PMID:2115126
TFEB	P19484	71	156	106	106	Sequence conflict	Note=A->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFEB	P19484	71	156	106	106	Sequence conflict	Note=A->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFEB	P19484	71	156	106	106	Sequence conflict	Note=A->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFEB	P19484	71	156	113	141	Sequence conflict	Note=GSPKPPPAASPGVRAGHVLSSSAGNSAPN->ALRNPHQPPPQGCELDTCCPPPLATVLPI;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFEB	P19484	71	156	113	141	Sequence conflict	Note=GSPKPPPAASPGVRAGHVLSSSAGNSAPN->ALRNPHQPPPQGCELDTCCPPPLATVLPI;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFEB	P19484	71	156	113	141	Sequence conflict	Note=GSPKPPPAASPGVRAGHVLSSSAGNSAPN->ALRNPHQPPPQGCELDTCCPPPLATVLPI;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFEC	O14948	127	146	1	347	Chain	ID=PRO_0000313564;Note=Transcription factor EC
TFEC	O14948	60	89	1	347	Chain	ID=PRO_0000313564;Note=Transcription factor EC
TFEC	O14948	127	146	139	192	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
TFEC	O14948	60	89	1	119	Region	Note=Necessary for transcriptional transactivation
TFEC	O14948	60	89	1	67	Alternative sequence	ID=VSP_030022;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15118077;Dbxref=PMID:15118077
TFEC	O14948	60	89	61	89	Alternative sequence	ID=VSP_030023;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
TFEC	O14948	60	89	68	89	Alternative sequence	ID=VSP_030024;Note=In isoform 4. IIGMESSFKEEGADSPLLMQRT->MMKEKEKTIAIVKVIDTSKLKL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15118077;Dbxref=PMID:15118077
TFEC	O14948	127	146	146	146	Natural variant	ID=VAR_037663;Note=In a colorectal cancer sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SAP30	O75446	105	147	1	220	Chain	ID=PRO_0000097582;Note=Histone deacetylase complex subunit SAP30
SAP30	O75446	147	180	1	220	Chain	ID=PRO_0000097582;Note=Histone deacetylase complex subunit SAP30
SAP30	O75446	105	147	67	115	Zinc finger	Note=Atypical
SAP30	O75446	105	147	1	129	Region	Note=Interaction with NCOR1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAP30	O75446	105	147	130	220	Region	Note=Interaction with SIN3A;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAP30	O75446	147	180	130	220	Region	Note=Interaction with SIN3A;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAP30	O75446	105	147	131	131	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692
SAP30	O75446	105	147	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:21406692
SAP30	O75446	105	147	145	145	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SAP30	O75446	105	147	108	108	Mutagenesis	Note=Retains zinc-binding. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19223330;Dbxref=PMID:19223330
SAP30	O75446	105	147	112	112	Mutagenesis	Note=Abolishes zinc-binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19223330;Dbxref=PMID:19223330
SAP30	O75446	105	147	113	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDP
SAP30	O75446	105	147	123	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDP
TFG	Q92734	61	89	1	400	Chain	ID=PRO_0000072500;Note=Protein TFG
TFG	Q92734	61	89	1	400	Chain	ID=PRO_0000072500;Note=Protein TFG
TFG	Q92734	61	89	10	91	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
TFG	Q92734	61	89	10	91	Domain	Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081
SAR1B	Q9Y6B6	59	81	1	198	Chain	ID=PRO_0000206261;Note=GTP-binding protein SAR1b
SAR1B	Q9Y6B6	19	59	1	198	Chain	ID=PRO_0000206261;Note=GTP-binding protein SAR1b
SAR1B	Q9Y6B6	59	81	1	198	Chain	ID=PRO_0000206261;Note=GTP-binding protein SAR1b
SAR1B	Q9Y6B6	19	59	1	198	Chain	ID=PRO_0000206261;Note=GTP-binding protein SAR1b
SAR1B	Q9Y6B6	19	59	32	39	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	19	59	32	39	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	59	81	75	78	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	59	81	75	78	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	19	59	34	34	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	19	59	34	34	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	59	81	75	75	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	59	81	75	75	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAR1B	Q9Y6B6	19	59	37	37	Natural variant	ID=VAR_016806;Note=In CMRD%3B loss of GDP/GTP-binding. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12692552;Dbxref=dbSNP:rs121917846,PMID:12692552
SAR1B	Q9Y6B6	19	59	37	37	Natural variant	ID=VAR_016806;Note=In CMRD%3B loss of GDP/GTP-binding. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12692552;Dbxref=dbSNP:rs121917846,PMID:12692552
SAR1B	Q9Y6B6	59	81	75	75	Natural variant	ID=VAR_059052;Note=In CMRD. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19274794;Dbxref=dbSNP:rs1254114609,PMID:19274794
SAR1B	Q9Y6B6	59	81	75	75	Natural variant	ID=VAR_059052;Note=In CMRD. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19274794;Dbxref=dbSNP:rs1254114609,PMID:19274794
SARDH	Q9UL12	490	518	23	918	Chain	ID=PRO_0000010770;Note=Sarcosine dehydrogenase%2C mitochondrial
SARDH	Q9UL12	490	518	23	918	Chain	ID=PRO_0000010770;Note=Sarcosine dehydrogenase%2C mitochondrial
SASH3	O75995	51	100	1	380	Chain	ID=PRO_0000071962;Note=SAM and SH3 domain-containing protein 3
SASH3	O75995	197	267	1	380	Chain	ID=PRO_0000071962;Note=SAM and SH3 domain-containing protein 3
SASH3	O75995	197	267	173	234	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SASH3	O75995	197	267	252	316	Domain	Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184
SASH3	O75995	51	100	61	61	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SASH3	O75995	51	100	97	97	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SASH3	O75995	51	100	79	79	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
KITLG	P21583	5	43	1	25	Signal peptide	.
KITLG	P21583	173	201	26	273	Chain	ID=PRO_0000031913;Note=Kit ligand
KITLG	P21583	64	121	26	273	Chain	ID=PRO_0000031913;Note=Kit ligand
KITLG	P21583	43	64	26	273	Chain	ID=PRO_0000031913;Note=Kit ligand
KITLG	P21583	5	43	26	273	Chain	ID=PRO_0000031913;Note=Kit ligand
KITLG	P21583	173	201	26	190	Chain	ID=PRO_0000403391;Note=Soluble KIT ligand
KITLG	P21583	64	121	26	190	Chain	ID=PRO_0000403391;Note=Soluble KIT ligand
KITLG	P21583	43	64	26	190	Chain	ID=PRO_0000403391;Note=Soluble KIT ligand
KITLG	P21583	5	43	26	190	Chain	ID=PRO_0000403391;Note=Soluble KIT ligand
KITLG	P21583	173	201	26	214	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KITLG	P21583	64	121	26	214	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KITLG	P21583	43	64	26	214	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KITLG	P21583	5	43	26	214	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KITLG	P21583	64	121	97	97	Site	Note=Not glycosylated
KITLG	P21583	64	121	90	90	Glycosylation	Note=N-linked (GlcNAc...) asparagine%3B partial;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1381905;Dbxref=PMID:1381905
KITLG	P21583	64	121	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine%3B partial;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1381905;Dbxref=PMID:1381905
KITLG	P21583	173	201	180	180	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1381905;Dbxref=PMID:1381905
KITLG	P21583	173	201	195	195	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KITLG	P21583	64	121	29	114	Disulfide bond	.
KITLG	P21583	43	64	29	114	Disulfide bond	.
KITLG	P21583	5	43	29	114	Disulfide bond	.
KITLG	P21583	64	121	68	163	Disulfide bond	.
KITLG	P21583	5	43	1	35	Alternative sequence	ID=VSP_032762;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KITLG	P21583	43	64	36	43	Alternative sequence	ID=VSP_032763;Note=In isoform 3. NVKDVTKL->MPSCLAAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KITLG	P21583	5	43	36	43	Alternative sequence	ID=VSP_032763;Note=In isoform 3. NVKDVTKL->MPSCLAAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
KITLG	P21583	173	201	174	202	Alternative sequence	ID=VSP_006022;Note=In isoform 2. DSRVSVTKPFMLPPVAASSLRNDSSSSNR->G;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10049787,ECO:0000303|PubMed:1379846,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1724381,ECO:0000303|Ref.4;Dbxref=PMID:10049787,PMID:1379846,PMID:14702039,PMID:15489334,PMID:1724381
KITLG	P21583	5	43	36	36	Natural variant	ID=VAR_063237;Note=In FPHH%3B gain-of-function mutation%3B sKITLG reveales that the mutant Ser-36 sKITLG increases the content of the melanin by 109%25 compared with the wild-type sKITLG%3B tyrosinase activity is significantly increased by the mutant sKITLG compared to wild-type control. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19375057;Dbxref=dbSNP:rs121918653,PMID:19375057
KITLG	P21583	43	64	54	54	Natural variant	ID=VAR_042652;Note=T->A;Dbxref=dbSNP:rs3741457
KITLG	P21583	64	121	67	68	Natural variant	ID=VAR_076222;Note=In DCUA%3B loss of cell membrane association. HC->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522471;Dbxref=PMID:26522471
KITLG	P21583	64	121	104	104	Natural variant	ID=VAR_076223;Note=Found in a patient with Waardenburg syndrome type 2 (WS2) and hearing loss%3B unknown pathological significance%3B reduces secretion. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26522471;Dbxref=dbSNP:rs864309655,PMID:26522471
KITLG	P21583	43	64	55	55	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KITLG	P21583	43	64	55	55	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KITLG	P21583	5	43	30	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9W
KITLG	P21583	43	64	37	46	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	5	43	37	46	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	43	64	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	43	64	59	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	64	121	66	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	64	121	70	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	64	121	92	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9W
KITLG	P21583	64	121	97	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SCF
KITLG	P21583	64	121	120	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EXZ
SCAF8	Q9UPN6	38	53	1	1271	Chain	ID=PRO_0000081780;Note=Protein SCAF8
SCAF8	Q9UPN6	53	107	1	1271	Chain	ID=PRO_0000081780;Note=Protein SCAF8
SCAF8	Q9UPN6	202	261	1	1271	Chain	ID=PRO_0000081780;Note=Protein SCAF8
SCAF8	Q9UPN6	507	545	1	1271	Chain	ID=PRO_0000081780;Note=Protein SCAF8
SCAF8	Q9UPN6	38	53	1	139	Domain	Note=CID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00724
SCAF8	Q9UPN6	53	107	1	139	Domain	Note=CID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00724
SCAF8	Q9UPN6	507	545	477	551	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SCAF8	Q9UPN6	202	261	193	371	Compositional bias	Note=Gln-rich
SCAF8	Q9UPN6	38	53	37	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	38	53	40	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	40	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	56	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	59	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	84	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	92	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	104	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCAF8	Q9UPN6	53	107	107	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9J
SCARA5	Q6ZMJ2	384	450	1	495	Chain	ID=PRO_0000279518;Note=Scavenger receptor class A member 5
SCARA5	Q6ZMJ2	365	384	1	495	Chain	ID=PRO_0000279518;Note=Scavenger receptor class A member 5
SCARA5	Q6ZMJ2	305	332	1	495	Chain	ID=PRO_0000279518;Note=Scavenger receptor class A member 5
SCARA5	Q6ZMJ2	80	305	1	495	Chain	ID=PRO_0000279518;Note=Scavenger receptor class A member 5
SCARA5	Q6ZMJ2	37	80	1	495	Chain	ID=PRO_0000279518;Note=Scavenger receptor class A member 5
SCARA5	Q6ZMJ2	37	80	1	60	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	61	81	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	37	80	61	81	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	384	450	82	495	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	365	384	82	495	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	305	332	82	495	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	82	495	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	305	332	305	357	Domain	Note=Collagen-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	305	357	Domain	Note=Collagen-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	384	450	393	493	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	91	111	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	102	102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	134	134	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	193	193	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	231	231	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	254	254	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	384	450	397	397	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	384	450	418	482	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	384	450	431	492	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03070
SCARA5	Q6ZMJ2	80	305	38	80	Alternative sequence	ID=VSP_023472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SCARA5	Q6ZMJ2	37	80	38	80	Alternative sequence	ID=VSP_023472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
SCARA5	Q6ZMJ2	305	332	81	305	Alternative sequence	ID=VSP_023473;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SCARA5	Q6ZMJ2	80	305	81	305	Alternative sequence	ID=VSP_023473;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SCARA5	Q6ZMJ2	384	450	386	400	Alternative sequence	ID=VSP_023474;Note=In isoform 2 and isoform 3. GVEAPMMIRLVNGSG->KDILLGPWDMVLAQG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SCARA5	Q6ZMJ2	384	450	401	495	Alternative sequence	ID=VSP_023475;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
SCARA5	Q6ZMJ2	37	80	45	45	Natural variant	ID=VAR_052062;Note=A->T;Dbxref=dbSNP:rs17058374
SCARA5	Q6ZMJ2	305	332	316	316	Natural variant	ID=VAR_030915;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs17058207
SCARA5	Q6ZMJ2	80	305	93	93	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCARA5	Q6ZMJ2	80	305	95	95	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCARA5	Q6ZMJ2	80	305	108	108	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCARA5	Q6ZMJ2	80	305	246	246	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCARA5	Q6ZMJ2	365	384	377	377	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCLT1	Q96NL6	636	668	2	688	Chain	ID=PRO_0000317127;Note=Sodium channel and clathrin linker 1
SCLT1	Q96NL6	636	668	69	673	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCLT1	Q96NL6	636	668	80	688	Alternative sequence	ID=VSP_030905;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SCN4A	P35499	1240	1258	1	1836	Chain	ID=PRO_0000048495;Note=Sodium channel protein type 4 subunit alpha
SCN4A	P35499	1048	1106	1	1836	Chain	ID=PRO_0000048495;Note=Sodium channel protein type 4 subunit alpha
SCN4A	P35499	1048	1106	1033	1050	Transmembrane	Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN4A	P35499	1048	1106	1051	1063	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN4A	P35499	1048	1106	1064	1082	Transmembrane	Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN4A	P35499	1048	1106	1083	1096	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN4A	P35499	1048	1106	1097	1115	Transmembrane	Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN4A	P35499	1240	1258	1231	1252	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN4A	P35499	1240	1258	1253	1269	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN4A	P35499	1240	1258	1013	1326	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN4A	P35499	1048	1106	1013	1326	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN4A	P35499	1048	1106	1069	1069	Natural variant	ID=VAR_075433;Note=Probable disease-associated mutation found in patients with severe fetal hypokinesia or congenital myopathy%3B impaired sodium channel function. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26700687;Dbxref=dbSNP:rs373150395,PMID:26700687
SCNN1A	P37088	381	414	1	669	Chain	ID=PRO_0000181261;Note=Amiloride-sensitive sodium channel subunit alpha
SCNN1A	P37088	381	414	107	562	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P37089
SCNN1A	P37088	381	414	246	669	Alternative sequence	ID=VSP_007721;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCNN1A	P37088	381	414	402	402	Natural variant	ID=VAR_052035;Note=P->H;Dbxref=dbSNP:rs13306616
SCO1	O75880	121	187	68	301	Chain	ID=PRO_0000031921;Note=Protein SCO1 homolog%2C mitochondrial
SCO1	O75880	121	187	112	301	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15229189;Dbxref=PMID:15229189
SCO1	O75880	121	187	118	131	Region	Note=Important for dimerization
SCO1	O75880	121	187	169	169	Metal binding	Note=Copper
SCO1	O75880	121	187	173	173	Metal binding	Note=Copper
SCO1	O75880	121	187	169	173	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
SCO1	O75880	121	187	174	174	Natural variant	ID=VAR_012109;Note=In MT-C4D%3B no effect on synthesis of cytochrome c oxidase subunit II%3B reduced stability of newly synthesized cytochrome c oxidase subunit II%3B reduced copper-binding. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11013136,ECO:0000269|PubMed:17182746,ECO:0000269|PubMed:17189203,ECO:0000269|PubMed:19336478;Dbxref=dbSNP:rs104894630,PMID:11013136,PMID:17182746,PMID:17189203,PMID:19336478
SCO1	O75880	121	187	141	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GGT
SCO1	O75880	121	187	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GGT
SCO1	O75880	121	187	152	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GGT
SCO1	O75880	121	187	159	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GGT
SCO1	O75880	121	187	172	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GGT
SCARB1	Q8WTV0	210	242	1	552	Chain	ID=PRO_0000144160;Note=Scavenger receptor class B member 1
SCARB1	Q8WTV0	210	242	33	443	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARB1	Q8WTV0	210	242	212	212	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARB1	Q8WTV0	210	242	227	227	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCARB1	Q8WTV0	210	242	229	229	Natural variant	ID=VAR_019507;Note=S->G;Dbxref=dbSNP:rs10396213
SCCPDH	Q8NBX0	101	128	2	429	Chain	ID=PRO_0000212840;Note=Saccharopine dehydrogenase-like oxidoreductase
SCCPDH	Q8NBX0	311	330	2	429	Chain	ID=PRO_0000212840;Note=Saccharopine dehydrogenase-like oxidoreductase
SCRN1	Q12765	181	246	2	414	Chain	ID=PRO_0000221436;Note=Secernin-1
SCRN1	Q12765	181	246	2	414	Chain	ID=PRO_0000221436;Note=Secernin-1
SCRN1	Q12765	181	246	2	414	Chain	ID=PRO_0000221436;Note=Secernin-1
SCRN1	Q12765	181	246	189	189	Natural variant	ID=VAR_057709;Note=S->N;Dbxref=dbSNP:rs35960711
SCRN1	Q12765	181	246	189	189	Natural variant	ID=VAR_057709;Note=S->N;Dbxref=dbSNP:rs35960711
SCRN1	Q12765	181	246	189	189	Natural variant	ID=VAR_057709;Note=S->N;Dbxref=dbSNP:rs35960711
SCRN3	Q0VDG4	180	251	1	424	Chain	ID=PRO_0000262559;Note=Secernin-3
THAP3	Q8WTV1	89	111	1	239	Chain	ID=PRO_0000068644;Note=THAP domain-containing protein 3
THAP3	Q8WTV1	111	146	1	239	Chain	ID=PRO_0000068644;Note=THAP domain-containing protein 3
THAP3	Q8WTV1	111	146	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
THAP3	Q8WTV1	89	111	89	89	Alternative sequence	ID=VSP_015136;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
THAP3	Q8WTV1	89	111	111	111	Alternative sequence	ID=VSP_015137;Note=In isoform 3. K->KTSPCRSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
THAP3	Q8WTV1	111	146	111	111	Alternative sequence	ID=VSP_015137;Note=In isoform 3. K->KTSPCRSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
THAP7	Q9BT49	27	78	1	309	Chain	ID=PRO_0000068648;Note=THAP domain-containing protein 7
THAP7	Q9BT49	27	78	1	309	Chain	ID=PRO_0000068648;Note=THAP domain-containing protein 7
THAP7	Q9BT49	27	78	1	93	Zinc finger	Note=THAP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00309
THAP7	Q9BT49	27	78	1	93	Zinc finger	Note=THAP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00309
SCYL1	Q96KG9	372	410	1	808	Chain	ID=PRO_0000249541;Note=N-terminal kinase-like protein
SCYL1	Q96KG9	410	462	1	808	Chain	ID=PRO_0000249541;Note=N-terminal kinase-like protein
SCYL1	Q96KG9	677	749	1	808	Chain	ID=PRO_0000249541;Note=N-terminal kinase-like protein
SCYL1	Q96KG9	372	410	350	388	Repeat	Note=HEAT 1
SCYL1	Q96KG9	372	410	389	427	Repeat	Note=HEAT 2
SCYL1	Q96KG9	410	462	389	427	Repeat	Note=HEAT 2
SCYL1	Q96KG9	677	749	627	808	Alternative sequence	ID=VSP_020505;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
SCYL1	Q96KG9	677	749	628	711	Alternative sequence	ID=VSP_020506;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12036289;Dbxref=PMID:12036289
SCYL1	Q96KG9	677	749	678	808	Alternative sequence	ID=VSP_020507;Note=In isoform 6. VSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKLD->SPTGAAGKLRAPGNRAGRSQAPRSHLLTVHGWPASITGVAQSPATRATPSLPCLHVPAPSRGQTLGVRTTGRASRLTVDRSRLSWPGRSARSGGGRWRPNAPRGRWPRAP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15504359;Dbxref=PMID:15504359
THRA	P10827	192	241	1	490	Chain	ID=PRO_0000053424;Note=Thyroid hormone receptor alpha
THRA	P10827	192	241	1	490	Chain	ID=PRO_0000053424;Note=Thyroid hormone receptor alpha
THRA	P10827	192	241	163	407	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
THRA	P10827	192	241	163	407	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
THRA	P10827	192	241	228	228	Binding site	Note=Thyroid hormone
THRA	P10827	192	241	228	228	Binding site	Note=Thyroid hormone
THRA	P10827	192	241	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H79
THRA	P10827	192	241	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H79
THRA	P10827	192	241	212	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ILZ
THRA	P10827	192	241	212	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ILZ
THRA	P10827	192	241	237	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ILZ
THRA	P10827	192	241	237	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ILZ
SCYL2	Q6P3W7	284	323	1	929	Chain	ID=PRO_0000252446;Note=SCY1-like protein 2
SCYL2	Q6P3W7	675	715	1	929	Chain	ID=PRO_0000252446;Note=SCY1-like protein 2
SCYL2	Q6P3W7	284	323	32	327	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SCYL2	Q6P3W7	675	715	699	929	Region	Note=Necessary for interaction with AP2 complex and clathrin%2C interaction with clathrin is necessary for its targeting to the TGN and endosomal membranes
SCYL2	Q6P3W7	675	715	661	701	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SCYL2	Q6P3W7	675	715	677	677	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SCYL2	Q6P3W7	675	715	708	708	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SDCBP	O00560	80	134	2	298	Chain	ID=PRO_0000184001;Note=Syntenin-1
SDCBP	O00560	80	134	2	298	Chain	ID=PRO_0000184001;Note=Syntenin-1
SDCBP	O00560	80	134	114	193	Domain	Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SDCBP	O00560	80	134	114	193	Domain	Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SDCBP	O00560	80	134	81	81	Alternative sequence	ID=VSP_038375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SDCBP	O00560	80	134	81	81	Alternative sequence	ID=VSP_038375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SDCBP	O00560	80	134	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9E
SDCBP	O00560	80	134	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9E
SDCBP	O00560	80	134	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9O
SDCBP	O00560	80	134	121	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9O
SDCBP	O00560	80	134	126	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9E
SDCBP	O00560	80	134	126	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9E
SYMPK	Q92797	1086	1118	1	1274	Chain	ID=PRO_0000072385;Note=Symplekin
SYMPK	Q92797	1027	1086	1	1274	Chain	ID=PRO_0000072385;Note=Symplekin
SYMPK	Q92797	282	362	1	1274	Chain	ID=PRO_0000072385;Note=Symplekin
SYMPK	Q92797	225	282	1	1274	Chain	ID=PRO_0000072385;Note=Symplekin
SYMPK	Q92797	225	282	227	266	Repeat	Note=HEAT 5
SYMPK	Q92797	282	362	345	360	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYMPK	Q92797	282	362	361	361	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
SYMPK	Q92797	282	362	361	361	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:28112733
SYMPK	Q92797	1086	1118	673	1274	Alternative sequence	ID=VSP_014843;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SYMPK	Q92797	1027	1086	673	1274	Alternative sequence	ID=VSP_014843;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SYMPK	Q92797	225	282	225	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	225	282	250	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	225	282	268	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	271	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	225	282	271	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	287	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ODS
SYMPK	Q92797	282	362	291	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	294	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	312	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	332	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3O2T
SYMPK	Q92797	282	362	342	345	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ODS
NARS2	Q96I59	171	198	15	477	Chain	ID=PRO_0000250722;Note=Probable asparagine--tRNA ligase%2C mitochondrial
NARS2	Q96I59	171	198	1	227	Alternative sequence	ID=VSP_054120;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYT15	Q9BQS2	314	374	1	421	Chain	ID=PRO_0000183980;Note=Synaptotagmin-15
SYT15	Q9BQS2	314	374	30	421	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYT15	Q9BQS2	314	374	280	383	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SYT15	Q9BQS2	314	374	333	348	Alternative sequence	ID=VSP_008644;Note=In isoform 4. KTSAVLGSINPVYNET->PGPGLGEESRGSLNLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SYT15	Q9BQS2	314	374	349	421	Alternative sequence	ID=VSP_008645;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TARS	P26639	19	46	1	723	Chain	ID=PRO_0000101119;Note=Threonine--tRNA ligase%2C cytoplasmic
TARS	P26639	577	611	1	723	Chain	ID=PRO_0000101119;Note=Threonine--tRNA ligase%2C cytoplasmic
TARS	P26639	19	46	1	723	Chain	ID=PRO_0000101119;Note=Threonine--tRNA ligase%2C cytoplasmic
TARS	P26639	577	611	1	723	Chain	ID=PRO_0000101119;Note=Threonine--tRNA ligase%2C cytoplasmic
TARS	P26639	19	46	39	39	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TARS	P26639	19	46	39	39	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TARS	P26639	19	46	21	21	Natural variant	ID=VAR_034533;Note=G->D;Dbxref=dbSNP:rs34334786
TARS	P26639	19	46	21	21	Natural variant	ID=VAR_034533;Note=G->D;Dbxref=dbSNP:rs34334786
TARS	P26639	577	611	581	581	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TARS	P26639	577	611	581	581	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TARS	P26639	577	611	587	595	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HWT
TARS	P26639	577	611	587	595	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HWT
TARS	P26639	577	611	597	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HWT
TARS	P26639	577	611	597	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HWT
TARS	P26639	577	611	608	610	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HWT
TARS	P26639	577	611	608	610	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HWT
TRMT44	Q8IYL2	318	341	1	757	Chain	ID=PRO_0000249894;Note=Probable tRNA (uracil-O(2)-)-methyltransferase
TRMT44	Q8IYL2	341	377	1	757	Chain	ID=PRO_0000249894;Note=Probable tRNA (uracil-O(2)-)-methyltransferase
TRMT44	Q8IYL2	318	341	1	392	Alternative sequence	ID=VSP_039538;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRMT44	Q8IYL2	341	377	1	392	Alternative sequence	ID=VSP_039538;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRMT44	Q8IYL2	341	377	352	352	Natural variant	ID=VAR_027515;Note=R->G;Dbxref=dbSNP:rs1880024
TMEM179B	Q7Z7N9	95	139	1	219	Chain	ID=PRO_0000328987;Note=Transmembrane protein 179B
TMEM179B	Q7Z7N9	95	139	96	116	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM183A	Q8IXX5	236	263	1	376	Chain	ID=PRO_0000089251;Note=Transmembrane protein 183A
TMEM183A	Q8IXX5	263	315	1	376	Chain	ID=PRO_0000089251;Note=Transmembrane protein 183A
TMEM183A	Q8IXX5	263	315	300	320	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM183A	Q8IXX5	236	263	237	376	Alternative sequence	ID=VSP_015084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM183A	Q8IXX5	263	315	237	376	Alternative sequence	ID=VSP_015084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM255A	Q5JRV8	249	297	1	349	Chain	ID=PRO_0000266037;Note=Transmembrane protein 255A
TMEM255A	Q5JRV8	141	165	1	349	Chain	ID=PRO_0000266037;Note=Transmembrane protein 255A
TMEM255A	Q5JRV8	67	88	1	349	Chain	ID=PRO_0000266037;Note=Transmembrane protein 255A
TMEM255A	Q5JRV8	67	88	57	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM255A	Q5JRV8	249	297	285	349	Compositional bias	Note=Pro-rich
TMEM255A	Q5JRV8	141	165	1	164	Alternative sequence	ID=VSP_021920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM255A	Q5JRV8	67	88	1	164	Alternative sequence	ID=VSP_021920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM255A	Q5JRV8	141	165	141	164	Alternative sequence	ID=VSP_046825;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM255A	Q5JRV8	249	297	142	249	Alternative sequence	ID=VSP_046826;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM255A	Q5JRV8	141	165	142	249	Alternative sequence	ID=VSP_046826;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM255A	Q5JRV8	141	165	165	165	Alternative sequence	ID=VSP_021921;Note=In isoform 2. E->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TM4SF19	Q96DZ7	67	93	1	209	Chain	ID=PRO_0000219305;Note=Transmembrane 4 L6 family member 19
TM4SF19	Q96DZ7	67	93	60	80	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM4SF19	Q96DZ7	67	93	81	93	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM4SF19	Q96DZ7	67	93	72	97	Alternative sequence	ID=VSP_045895;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TACC3	Q9Y6A5	102	461	2	838	Chain	ID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
TACC3	Q9Y6A5	102	461	2	838	Chain	ID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
TACC3	Q9Y6A5	102	461	2	838	Chain	ID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
TACC3	Q9Y6A5	102	461	155	160	Compositional bias	Note=Poly-Ser
TACC3	Q9Y6A5	102	461	155	160	Compositional bias	Note=Poly-Ser
TACC3	Q9Y6A5	102	461	155	160	Compositional bias	Note=Poly-Ser
TACC3	Q9Y6A5	102	461	175	175	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TACC3	Q9Y6A5	102	461	175	175	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TACC3	Q9Y6A5	102	461	175	175	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TACC3	Q9Y6A5	102	461	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TACC3	Q9Y6A5	102	461	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TACC3	Q9Y6A5	102	461	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TACC3	Q9Y6A5	102	461	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TACC3	Q9Y6A5	102	461	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TACC3	Q9Y6A5	102	461	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TACC3	Q9Y6A5	102	461	317	317	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TACC3	Q9Y6A5	102	461	317	317	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TACC3	Q9Y6A5	102	461	317	317	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TACC3	Q9Y6A5	102	461	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TACC3	Q9Y6A5	102	461	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TACC3	Q9Y6A5	102	461	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TACC3	Q9Y6A5	102	461	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
TACC3	Q9Y6A5	102	461	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
TACC3	Q9Y6A5	102	461	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
TACC3	Q9Y6A5	102	461	143	143	Natural variant	ID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
TACC3	Q9Y6A5	102	461	143	143	Natural variant	ID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
TACC3	Q9Y6A5	102	461	143	143	Natural variant	ID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
TACC3	Q9Y6A5	102	461	275	275	Natural variant	ID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
TACC3	Q9Y6A5	102	461	275	275	Natural variant	ID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
TACC3	Q9Y6A5	102	461	275	275	Natural variant	ID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
TACC3	Q9Y6A5	102	461	287	287	Natural variant	ID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
TACC3	Q9Y6A5	102	461	287	287	Natural variant	ID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
TACC3	Q9Y6A5	102	461	287	287	Natural variant	ID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
TACC3	Q9Y6A5	102	461	342	342	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TACC3	Q9Y6A5	102	461	342	342	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TACC3	Q9Y6A5	102	461	342	342	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TACC3	Q9Y6A5	102	461	406	406	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TACC3	Q9Y6A5	102	461	406	406	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TACC3	Q9Y6A5	102	461	406	406	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAF4	O00268	658	741	1	1085	Chain	ID=PRO_0000118869;Note=Transcription initiation factor TFIID subunit 4
TAF4	O00268	658	741	590	687	Domain	Note=TAFH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00440
TAF4	O00268	658	741	682	685	Compositional bias	Note=Poly-Pro
TAF4	O00268	658	741	661	666	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P6V
TAF4	O00268	658	741	671	677	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P6V
TAMM41	Q96BW9	45	106	25	452	Chain	ID=PRO_0000248354;Note=Phosphatidate cytidylyltransferase%2C mitochondrial
TARBP1	Q13395	1235	1264	1	1621	Chain	ID=PRO_0000273201;Note=Probable methyltransferase TARBP1
TARBP1	Q13395	1185	1235	1	1621	Chain	ID=PRO_0000273201;Note=Probable methyltransferase TARBP1
TARBP1	Q13395	1084	1107	1	1621	Chain	ID=PRO_0000273201;Note=Probable methyltransferase TARBP1
TARBP1	Q13395	957	1020	1	1621	Chain	ID=PRO_0000273201;Note=Probable methyltransferase TARBP1
TARBP1	Q13395	744	798	1	1621	Chain	ID=PRO_0000273201;Note=Probable methyltransferase TARBP1
TARBP1	Q13395	544	574	1	1621	Chain	ID=PRO_0000273201;Note=Probable methyltransferase TARBP1
TARBP1	Q13395	957	1020	997	997	Natural variant	ID=VAR_030106;Note=F->L;Dbxref=dbSNP:rs12135427
SUB1	P53999	24	65	2	127	Chain	ID=PRO_0000215944;Note=Activated RNA polymerase II transcriptional coactivator p15
SUB1	P53999	24	65	2	127	Chain	ID=PRO_0000215944;Note=Activated RNA polymerase II transcriptional coactivator p15
SUB1	P53999	24	65	2	127	Chain	ID=PRO_0000215944;Note=Activated RNA polymerase II transcriptional coactivator p15
SUB1	P53999	24	65	2	127	Chain	ID=PRO_0000215944;Note=Activated RNA polymerase II transcriptional coactivator p15
SUB1	P53999	24	65	2	50	Region	Note=Regulatory
SUB1	P53999	24	65	2	50	Region	Note=Regulatory
SUB1	P53999	24	65	2	50	Region	Note=Regulatory
SUB1	P53999	24	65	2	50	Region	Note=Regulatory
SUB1	P53999	24	65	23	53	Compositional bias	Note=Lys-rich
SUB1	P53999	24	65	23	53	Compositional bias	Note=Lys-rich
SUB1	P53999	24	65	23	53	Compositional bias	Note=Lys-rich
SUB1	P53999	24	65	23	53	Compositional bias	Note=Lys-rich
SUB1	P53999	24	65	50	58	Compositional bias	Note=Ser-rich
SUB1	P53999	24	65	50	58	Compositional bias	Note=Ser-rich
SUB1	P53999	24	65	50	58	Compositional bias	Note=Ser-rich
SUB1	P53999	24	65	50	58	Compositional bias	Note=Ser-rich
SUB1	P53999	24	65	50	51	Site	Note=Cleavage
SUB1	P53999	24	65	50	51	Site	Note=Cleavage
SUB1	P53999	24	65	50	51	Site	Note=Cleavage
SUB1	P53999	24	65	50	51	Site	Note=Cleavage
SUB1	P53999	24	65	35	35	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SUB1	P53999	24	65	35	35	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SUB1	P53999	24	65	35	35	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SUB1	P53999	24	65	35	35	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SUB1	P53999	24	65	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11031
SUB1	P53999	24	65	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11031
SUB1	P53999	24	65	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11031
SUB1	P53999	24	65	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11031
SUB1	P53999	24	65	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	55	55	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	57	57	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUB1	P53999	24	65	63	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PCF
SUB1	P53999	24	65	63	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PCF
SUB1	P53999	24	65	63	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PCF
SUB1	P53999	24	65	63	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PCF
TGS1	Q96RS0	427	455	1	853	Chain	ID=PRO_0000204468;Note=Trimethylguanosine synthase
TGS1	Q96RS0	427	455	438	438	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
SNCG	O76070	40	54	1	127	Chain	ID=PRO_0000184038;Note=Gamma-synuclein
SNCG	O76070	40	54	31	41	Repeat	Note=2
SNCG	O76070	40	54	42	56	Repeat	Note=3%3B approximate
SNCG	O76070	40	54	20	67	Region	Note=4 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)
SNCA	P37840	102	130	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	40	54	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	102	130	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	40	54	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	102	130	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	40	54	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	102	130	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	40	54	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	102	130	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	40	54	1	140	Chain	ID=PRO_0000184022;Note=Alpha-synuclein
SNCA	P37840	40	54	31	41	Repeat	Note=2
SNCA	P37840	40	54	31	41	Repeat	Note=2
SNCA	P37840	40	54	31	41	Repeat	Note=2
SNCA	P37840	40	54	31	41	Repeat	Note=2
SNCA	P37840	40	54	31	41	Repeat	Note=2
SNCA	P37840	40	54	42	56	Repeat	Note=3%3B approximate
SNCA	P37840	40	54	42	56	Repeat	Note=3%3B approximate
SNCA	P37840	40	54	42	56	Repeat	Note=3%3B approximate
SNCA	P37840	40	54	42	56	Repeat	Note=3%3B approximate
SNCA	P37840	40	54	42	56	Repeat	Note=3%3B approximate
SNCA	P37840	40	54	20	67	Region	Note=4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
SNCA	P37840	40	54	20	67	Region	Note=4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
SNCA	P37840	40	54	20	67	Region	Note=4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
SNCA	P37840	40	54	20	67	Region	Note=4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
SNCA	P37840	40	54	20	67	Region	Note=4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
SNCA	P37840	40	54	50	50	Metal binding	Note=Copper;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNCA	P37840	40	54	50	50	Metal binding	Note=Copper;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNCA	P37840	40	54	50	50	Metal binding	Note=Copper;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNCA	P37840	40	54	50	50	Metal binding	Note=Copper;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNCA	P37840	40	54	50	50	Metal binding	Note=Copper;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNCA	P37840	102	130	125	125	Modified residue	Note=Phosphotyrosine%3B by FYN;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11162638,ECO:0000269|PubMed:12893833;Dbxref=PMID:11162638,PMID:12893833
SNCA	P37840	102	130	125	125	Modified residue	Note=Phosphotyrosine%3B by FYN;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11162638,ECO:0000269|PubMed:12893833;Dbxref=PMID:11162638,PMID:12893833
SNCA	P37840	102	130	125	125	Modified residue	Note=Phosphotyrosine%3B by FYN;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11162638,ECO:0000269|PubMed:12893833;Dbxref=PMID:11162638,PMID:12893833
SNCA	P37840	102	130	125	125	Modified residue	Note=Phosphotyrosine%3B by FYN;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11162638,ECO:0000269|PubMed:12893833;Dbxref=PMID:11162638,PMID:12893833
SNCA	P37840	102	130	125	125	Modified residue	Note=Phosphotyrosine%3B by FYN;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11162638,ECO:0000269|PubMed:12893833;Dbxref=PMID:11162638,PMID:12893833
SNCA	P37840	102	130	129	129	Modified residue	Note=Phosphoserine%3B by BARK1%2C PLK2%2C CK2%2C CK1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10617630,ECO:0000269|PubMed:11813001,ECO:0000269|PubMed:24936070;Dbxref=PMID:10617630,PMID:11813001,PMID:24936070
SNCA	P37840	102	130	129	129	Modified residue	Note=Phosphoserine%3B by BARK1%2C PLK2%2C CK2%2C CK1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10617630,ECO:0000269|PubMed:11813001,ECO:0000269|PubMed:24936070;Dbxref=PMID:10617630,PMID:11813001,PMID:24936070
SNCA	P37840	102	130	129	129	Modified residue	Note=Phosphoserine%3B by BARK1%2C PLK2%2C CK2%2C CK1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10617630,ECO:0000269|PubMed:11813001,ECO:0000269|PubMed:24936070;Dbxref=PMID:10617630,PMID:11813001,PMID:24936070
SNCA	P37840	102	130	129	129	Modified residue	Note=Phosphoserine%3B by BARK1%2C PLK2%2C CK2%2C CK1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10617630,ECO:0000269|PubMed:11813001,ECO:0000269|PubMed:24936070;Dbxref=PMID:10617630,PMID:11813001,PMID:24936070
SNCA	P37840	102	130	129	129	Modified residue	Note=Phosphoserine%3B by BARK1%2C PLK2%2C CK2%2C CK1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10617630,ECO:0000269|PubMed:11813001,ECO:0000269|PubMed:24936070;Dbxref=PMID:10617630,PMID:11813001,PMID:24936070
SNCA	P37840	40	54	41	54	Alternative sequence	ID=VSP_006363;Note=In isoform 2-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7601450;Dbxref=PMID:7601450
SNCA	P37840	40	54	41	54	Alternative sequence	ID=VSP_006363;Note=In isoform 2-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7601450;Dbxref=PMID:7601450
SNCA	P37840	40	54	41	54	Alternative sequence	ID=VSP_006363;Note=In isoform 2-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7601450;Dbxref=PMID:7601450
SNCA	P37840	40	54	41	54	Alternative sequence	ID=VSP_006363;Note=In isoform 2-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7601450;Dbxref=PMID:7601450
SNCA	P37840	40	54	41	54	Alternative sequence	ID=VSP_006363;Note=In isoform 2-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7601450;Dbxref=PMID:7601450
SNCA	P37840	102	130	103	130	Alternative sequence	ID=VSP_006364;Note=In isoform 2-4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7601450,ECO:0000303|PubMed:7802671;Dbxref=PMID:7601450,PMID:7802671
SNCA	P37840	102	130	103	130	Alternative sequence	ID=VSP_006364;Note=In isoform 2-4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7601450,ECO:0000303|PubMed:7802671;Dbxref=PMID:7601450,PMID:7802671
SNCA	P37840	102	130	103	130	Alternative sequence	ID=VSP_006364;Note=In isoform 2-4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7601450,ECO:0000303|PubMed:7802671;Dbxref=PMID:7601450,PMID:7802671
SNCA	P37840	102	130	103	130	Alternative sequence	ID=VSP_006364;Note=In isoform 2-4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7601450,ECO:0000303|PubMed:7802671;Dbxref=PMID:7601450,PMID:7802671
SNCA	P37840	102	130	103	130	Alternative sequence	ID=VSP_006364;Note=In isoform 2-4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7601450,ECO:0000303|PubMed:7802671;Dbxref=PMID:7601450,PMID:7802671
SNCA	P37840	40	54	46	46	Natural variant	ID=VAR_022703;Note=In PARK1 and DLB%3B significant increase in binding to negatively charged phospholipid liposomes%3B increases oligomerization. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14755719,ECO:0000269|PubMed:15498564,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs104893875,PMID:14755719,PMID:15498564,PMID:25561023
SNCA	P37840	40	54	46	46	Natural variant	ID=VAR_022703;Note=In PARK1 and DLB%3B significant increase in binding to negatively charged phospholipid liposomes%3B increases oligomerization. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14755719,ECO:0000269|PubMed:15498564,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs104893875,PMID:14755719,PMID:15498564,PMID:25561023
SNCA	P37840	40	54	46	46	Natural variant	ID=VAR_022703;Note=In PARK1 and DLB%3B significant increase in binding to negatively charged phospholipid liposomes%3B increases oligomerization. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14755719,ECO:0000269|PubMed:15498564,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs104893875,PMID:14755719,PMID:15498564,PMID:25561023
SNCA	P37840	40	54	46	46	Natural variant	ID=VAR_022703;Note=In PARK1 and DLB%3B significant increase in binding to negatively charged phospholipid liposomes%3B increases oligomerization. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14755719,ECO:0000269|PubMed:15498564,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs104893875,PMID:14755719,PMID:15498564,PMID:25561023
SNCA	P37840	40	54	46	46	Natural variant	ID=VAR_022703;Note=In PARK1 and DLB%3B significant increase in binding to negatively charged phospholipid liposomes%3B increases oligomerization. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14755719,ECO:0000269|PubMed:15498564,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs104893875,PMID:14755719,PMID:15498564,PMID:25561023
SNCA	P37840	40	54	50	50	Natural variant	ID=VAR_070171;Note=In PARK1%3B no effect on protein structure%3B no effect on phosphorylation of the protein%3B no effect on membrane- and lipid-binding%3B increases oligomerization%3B increases fibril formation%3B increases secretion of the protein%3B impairs copper-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23427326,ECO:0000269|PubMed:23457019,ECO:0000269|PubMed:24936070,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs201106962,PMID:23427326,PMID:23457019,PMID:24936070,PMID:25561023
SNCA	P37840	40	54	50	50	Natural variant	ID=VAR_070171;Note=In PARK1%3B no effect on protein structure%3B no effect on phosphorylation of the protein%3B no effect on membrane- and lipid-binding%3B increases oligomerization%3B increases fibril formation%3B increases secretion of the protein%3B impairs copper-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23427326,ECO:0000269|PubMed:23457019,ECO:0000269|PubMed:24936070,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs201106962,PMID:23427326,PMID:23457019,PMID:24936070,PMID:25561023
SNCA	P37840	40	54	50	50	Natural variant	ID=VAR_070171;Note=In PARK1%3B no effect on protein structure%3B no effect on phosphorylation of the protein%3B no effect on membrane- and lipid-binding%3B increases oligomerization%3B increases fibril formation%3B increases secretion of the protein%3B impairs copper-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23427326,ECO:0000269|PubMed:23457019,ECO:0000269|PubMed:24936070,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs201106962,PMID:23427326,PMID:23457019,PMID:24936070,PMID:25561023
SNCA	P37840	40	54	50	50	Natural variant	ID=VAR_070171;Note=In PARK1%3B no effect on protein structure%3B no effect on phosphorylation of the protein%3B no effect on membrane- and lipid-binding%3B increases oligomerization%3B increases fibril formation%3B increases secretion of the protein%3B impairs copper-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23427326,ECO:0000269|PubMed:23457019,ECO:0000269|PubMed:24936070,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs201106962,PMID:23427326,PMID:23457019,PMID:24936070,PMID:25561023
SNCA	P37840	40	54	50	50	Natural variant	ID=VAR_070171;Note=In PARK1%3B no effect on protein structure%3B no effect on phosphorylation of the protein%3B no effect on membrane- and lipid-binding%3B increases oligomerization%3B increases fibril formation%3B increases secretion of the protein%3B impairs copper-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23427326,ECO:0000269|PubMed:23457019,ECO:0000269|PubMed:24936070,ECO:0000269|PubMed:25561023;Dbxref=dbSNP:rs201106962,PMID:23427326,PMID:23457019,PMID:24936070,PMID:25561023
SNCA	P37840	40	54	53	53	Natural variant	ID=VAR_007454;Note=In PARK1%3B no effect on osmotic stress-induced phosphorylation%3B increases oligomerization. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:25561023,ECO:0000269|PubMed:9197268;Dbxref=dbSNP:rs104893877,PMID:12893833,PMID:25561023,PMID:9197268
SNCA	P37840	40	54	53	53	Natural variant	ID=VAR_007454;Note=In PARK1%3B no effect on osmotic stress-induced phosphorylation%3B increases oligomerization. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:25561023,ECO:0000269|PubMed:9197268;Dbxref=dbSNP:rs104893877,PMID:12893833,PMID:25561023,PMID:9197268
SNCA	P37840	40	54	53	53	Natural variant	ID=VAR_007454;Note=In PARK1%3B no effect on osmotic stress-induced phosphorylation%3B increases oligomerization. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:25561023,ECO:0000269|PubMed:9197268;Dbxref=dbSNP:rs104893877,PMID:12893833,PMID:25561023,PMID:9197268
SNCA	P37840	40	54	53	53	Natural variant	ID=VAR_007454;Note=In PARK1%3B no effect on osmotic stress-induced phosphorylation%3B increases oligomerization. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:25561023,ECO:0000269|PubMed:9197268;Dbxref=dbSNP:rs104893877,PMID:12893833,PMID:25561023,PMID:9197268
SNCA	P37840	40	54	53	53	Natural variant	ID=VAR_007454;Note=In PARK1%3B no effect on osmotic stress-induced phosphorylation%3B increases oligomerization. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:25561023,ECO:0000269|PubMed:9197268;Dbxref=dbSNP:rs104893877,PMID:12893833,PMID:25561023,PMID:9197268
SNCA	P37840	40	54	50	50	Mutagenesis	Note=Impairs copper-binding. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21319811;Dbxref=PMID:21319811
SNCA	P37840	40	54	50	50	Mutagenesis	Note=Impairs copper-binding. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21319811;Dbxref=PMID:21319811
SNCA	P37840	40	54	50	50	Mutagenesis	Note=Impairs copper-binding. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21319811;Dbxref=PMID:21319811
SNCA	P37840	40	54	50	50	Mutagenesis	Note=Impairs copper-binding. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21319811;Dbxref=PMID:21319811
SNCA	P37840	40	54	50	50	Mutagenesis	Note=Impairs copper-binding. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21319811;Dbxref=PMID:21319811
SNCA	P37840	102	130	125	125	Mutagenesis	Note=Abolishes osmotic stress-induced phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12893833;Dbxref=PMID:12893833
SNCA	P37840	102	130	125	125	Mutagenesis	Note=Abolishes osmotic stress-induced phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12893833;Dbxref=PMID:12893833
SNCA	P37840	102	130	125	125	Mutagenesis	Note=Abolishes osmotic stress-induced phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12893833;Dbxref=PMID:12893833
SNCA	P37840	102	130	125	125	Mutagenesis	Note=Abolishes osmotic stress-induced phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12893833;Dbxref=PMID:12893833
SNCA	P37840	102	130	125	125	Mutagenesis	Note=Abolishes osmotic stress-induced phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12893833;Dbxref=PMID:12893833
SNCA	P37840	40	54	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXL
SNCA	P37840	40	54	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXL
SNCA	P37840	40	54	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXL
SNCA	P37840	40	54	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXL
SNCA	P37840	40	54	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BXL
SNCA	P37840	40	54	52	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	52	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	52	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	52	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	40	54	52	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q27
SNCA	P37840	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
SNCA	P37840	102	130	124	126	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQ8
WARS	P23381	371	418	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	313	371	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	141	180	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	371	418	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	313	371	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	141	180	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	371	418	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	313	371	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	141	180	2	471	Chain	ID=PRO_0000136738;Note=Tryptophan--tRNA ligase%2C cytoplasmic
WARS	P23381	371	418	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	313	371	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	141	180	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	371	418	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	313	371	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	141	180	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	371	418	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	313	371	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	141	180	71	471	Chain	ID=PRO_0000386461;Note=T1-TrpRS
WARS	P23381	371	418	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	313	371	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	141	180	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	371	418	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	313	371	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	141	180	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	371	418	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	313	371	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	141	180	94	471	Chain	ID=PRO_0000386462;Note=T2-TrpRS
WARS	P23381	141	180	164	173	Motif	Note="HIGH" region
WARS	P23381	141	180	164	173	Motif	Note="HIGH" region
WARS	P23381	141	180	164	173	Motif	Note="HIGH" region
WARS	P23381	313	371	349	353	Motif	Note="KMSKS" region
WARS	P23381	313	371	349	353	Motif	Note="KMSKS" region
WARS	P23381	313	371	349	353	Motif	Note="KMSKS" region
WARS	P23381	141	180	154	154	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32921
WARS	P23381	141	180	154	154	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32921
WARS	P23381	141	180	154	154	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32921
WARS	P23381	313	371	351	351	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
WARS	P23381	313	371	351	351	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
WARS	P23381	313	371	351	351	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
WARS	P23381	141	180	136	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	136	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	136	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	143	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	143	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	143	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	156	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	156	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	156	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJJ
WARS	P23381	141	180	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJJ
WARS	P23381	141	180	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJJ
WARS	P23381	141	180	171	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	171	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	141	180	171	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	311	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	311	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	311	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	314	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	314	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	314	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	324	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	324	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	324	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	333	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	333	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	333	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	345	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	345	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	345	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	354	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	354	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	354	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	360	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AZX
WARS	P23381	313	371	360	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AZX
WARS	P23381	313	371	360	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AZX
WARS	P23381	371	418	365	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	365	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	365	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	365	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	365	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	313	371	365	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	379	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJI
WARS	P23381	371	418	379	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJI
WARS	P23381	371	418	379	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UJI
WARS	P23381	371	418	384	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	384	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	384	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	394	396	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	394	396	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	394	396	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	398	406	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	398	406	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	398	406	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	410	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	410	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
WARS	P23381	371	418	410	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R6U
SZRD1	Q7Z422	34	118	1	152	Chain	ID=PRO_0000303068;Note=SUZ domain-containing protein 1
SZRD1	Q7Z422	34	118	42	107	Domain	Note=SUZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01009
SZRD1	Q7Z422	34	118	37	37	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569
SZRD1	Q7Z422	34	118	39	39	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
SZRD1	Q7Z422	34	118	51	51	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
SZRD1	Q7Z422	34	118	105	105	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
SZRD1	Q7Z422	34	118	107	107	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SZRD1	Q7Z422	34	118	1	35	Alternative sequence	ID=VSP_027995;Note=In isoform 2. MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESR->MRRSLRAGKRRQTAG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12761501,ECO:0000303|PubMed:17974005;Dbxref=PMID:12761501,PMID:17974005
SZRD1	Q7Z422	34	118	1	34	Alternative sequence	ID=VSP_027996;Note=In isoform 4. MEDEEVAESWEEAADSGEIDRRLEKKLKITQKES->MRRSLRAGKRRQTAG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12761501,ECO:0000303|PubMed:15489334;Dbxref=PMID:12761501,PMID:15489334
SZRD1	Q7Z422	34	118	18	35	Alternative sequence	ID=VSP_027997;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SZRD1	Q7Z422	34	118	34	34	Alternative sequence	ID=VSP_055690;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM106B	Q9NUM4	147	194	2	274	Chain	ID=PRO_0000242650;Note=Transmembrane protein 106B
TMEM106B	Q9NUM4	211	228	2	274	Chain	ID=PRO_0000242650;Note=Transmembrane protein 106B
TMEM106B	Q9NUM4	147	194	2	274	Chain	ID=PRO_0000242650;Note=Transmembrane protein 106B
TMEM106B	Q9NUM4	211	228	2	274	Chain	ID=PRO_0000242650;Note=Transmembrane protein 106B
TMEM106B	Q9NUM4	147	194	118	274	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106B	Q9NUM4	211	228	118	274	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106B	Q9NUM4	147	194	118	274	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106B	Q9NUM4	211	228	118	274	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106B	Q9NUM4	147	194	151	151	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511793;Dbxref=PMID:22511793
TMEM106B	Q9NUM4	147	194	151	151	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511793;Dbxref=PMID:22511793
TMEM106B	Q9NUM4	147	194	164	164	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511793;Dbxref=PMID:22511793
TMEM106B	Q9NUM4	147	194	164	164	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511793;Dbxref=PMID:22511793
TMEM106B	Q9NUM4	147	194	183	183	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:22511793,ECO:0000269|PubMed:23742080;Dbxref=PMID:19159218,PMID:22511793,PMID:23742080
TMEM106B	Q9NUM4	147	194	183	183	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:22511793,ECO:0000269|PubMed:23742080;Dbxref=PMID:19159218,PMID:22511793,PMID:23742080
TMEM106B	Q9NUM4	147	194	185	185	Natural variant	ID=VAR_026849;Note=T->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:23742080;Dbxref=dbSNP:rs3173615,PMID:14702039,PMID:23742080
TMEM106B	Q9NUM4	147	194	185	185	Natural variant	ID=VAR_026849;Note=T->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:23742080;Dbxref=dbSNP:rs3173615,PMID:14702039,PMID:23742080
TMEM106C	Q9BVX2	137	184	2	250	Chain	ID=PRO_0000243900;Note=Transmembrane protein 106C
TMEM106C	Q9BVX2	201	218	2	250	Chain	ID=PRO_0000243900;Note=Transmembrane protein 106C
TMEM106C	Q9BVX2	137	184	2	250	Chain	ID=PRO_0000243900;Note=Transmembrane protein 106C
TMEM106C	Q9BVX2	201	218	2	250	Chain	ID=PRO_0000243900;Note=Transmembrane protein 106C
TMEM106C	Q9BVX2	201	218	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106C	Q9BVX2	201	218	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106C	Q9BVX2	137	184	173	173	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106C	Q9BVX2	137	184	173	173	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM106C	Q9BVX2	137	184	166	184	Alternative sequence	ID=VSP_019483;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM106C	Q9BVX2	137	184	166	184	Alternative sequence	ID=VSP_019483;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM106C	Q9BVX2	137	184	175	175	Natural variant	ID=VAR_026868;Note=S->F;Dbxref=dbSNP:rs2286025
TMEM106C	Q9BVX2	137	184	175	175	Natural variant	ID=VAR_026868;Note=S->F;Dbxref=dbSNP:rs2286025
TMEM132A	Q24JP5	105	178	36	1023	Chain	ID=PRO_0000287096;Note=Transmembrane protein 132A
TMEM132A	Q24JP5	404	452	36	1023	Chain	ID=PRO_0000287096;Note=Transmembrane protein 132A
TMEM132A	Q24JP5	612	676	36	1023	Chain	ID=PRO_0000287096;Note=Transmembrane protein 132A
TMEM132A	Q24JP5	105	178	36	852	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132A	Q24JP5	404	452	36	852	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132A	Q24JP5	612	676	36	852	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132A	Q24JP5	612	676	611	916	Region	Note=Binds to HSPA5/GRP78;Ontology_term=ECO:0000250;evidence=ECO:0000250
TMEM132A	Q24JP5	612	676	671	1023	Region	Note=Confers cellular localization similar to full-length form;Ontology_term=ECO:0000250;evidence=ECO:0000250
TMEM132A	Q24JP5	105	178	46	295	Alternative sequence	ID=VSP_025303;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM132A	Q24JP5	404	452	405	423	Alternative sequence	ID=VSP_025305;Note=In isoform 3. AEELVNTAPLTGVPQHVPV->VRRPPSLPGKAGGQVPGAP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
TMEM132A	Q24JP5	404	452	424	1023	Alternative sequence	ID=VSP_025306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
TMEM132A	Q24JP5	612	676	424	1023	Alternative sequence	ID=VSP_025306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
TMEM132B	Q14DG7	315	363	1	1078	Chain	ID=PRO_0000284620;Note=Transmembrane protein 132B
TMEM132B	Q14DG7	315	363	1	903	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132B	Q14DG7	315	363	343	343	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM132B	Q14DG7	315	363	1	488	Alternative sequence	ID=VSP_024576;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM184B	Q9Y519	262	327	1	407	Chain	ID=PRO_0000211555;Note=Transmembrane protein 184B
TMEM184B	Q9Y519	262	327	1	407	Chain	ID=PRO_0000211555;Note=Transmembrane protein 184B
TMEM184B	Q9Y519	262	327	249	269	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM184B	Q9Y519	262	327	249	269	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM184B	Q9Y519	262	327	290	310	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM184B	Q9Y519	262	327	290	310	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TALDO1	P37837	74	109	1	337	Chain	ID=PRO_0000173564;Note=Transaldolase
TALDO1	P37837	110	153	1	337	Chain	ID=PRO_0000173564;Note=Transaldolase
TALDO1	P37837	212	278	1	337	Chain	ID=PRO_0000173564;Note=Transaldolase
TALDO1	P37837	110	153	142	142	Active site	Note=Schiff-base intermediate with substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10869557;Dbxref=PMID:10869557
TALDO1	P37837	110	153	115	115	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q93092
TALDO1	P37837	212	278	219	219	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TALDO1	P37837	212	278	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
TALDO1	P37837	212	278	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TALDO1	P37837	212	278	269	269	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TALDO1	P37837	74	109	76	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	74	109	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	74	109	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	110	153	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	110	153	115	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	110	153	136	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	110	153	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	110	153	147	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	212	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	232	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	241	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	246	249	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	257	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TALDO1	P37837	212	278	276	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1F05
TANC2	Q9HCD6	270	312	1	1990	Chain	ID=PRO_0000333811;Note=Protein TANC2
TANC2	Q9HCD6	1256	1305	1	1990	Chain	ID=PRO_0000333811;Note=Protein TANC2
TANC2	Q9HCD6	1256	1305	1244	1277	Repeat	Note=TPR 1
TANC2	Q9HCD6	1256	1305	1291	1324	Repeat	Note=TPR 2
TANC2	Q9HCD6	270	312	294	294	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TANC2	Q9HCD6	1256	1305	972	1990	Alternative sequence	ID=VSP_033547;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TANC2	Q9HCD6	1256	1305	1011	1990	Alternative sequence	ID=VSP_033549;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TANC2	Q9HCD6	1256	1305	1280	1280	Natural variant	ID=VAR_079853;Note=Found in a patient with isolated coloboma%3B unknown pathological significance. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493397;Dbxref=PMID:28493397
TANC2	Q9HCD6	1256	1305	1285	1285	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAOK1	Q7L7X3	44	68	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	150	187	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	333	401	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	446	525	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	525	568	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	568	636	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	716	787	1	1001	Chain	ID=PRO_0000086728;Note=Serine/threonine-protein kinase TAO1
TAOK1	Q7L7X3	44	68	28	281	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK1	Q7L7X3	150	187	28	281	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TAOK1	Q7L7X3	446	525	458	651	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK1	Q7L7X3	525	568	458	651	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK1	Q7L7X3	568	636	458	651	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK1	Q7L7X3	716	787	754	877	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAOK1	Q7L7X3	333	401	330	334	Compositional bias	Note=Poly-Glu
TAOK1	Q7L7X3	333	401	347	379	Compositional bias	Note=Ser-rich
TAOK1	Q7L7X3	150	187	151	151	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
TAOK1	Q7L7X3	44	68	57	57	Binding site	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAOK1	Q7L7X3	44	68	1	174	Alternative sequence	ID=VSP_015964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAOK1	Q7L7X3	150	187	1	174	Alternative sequence	ID=VSP_015964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAOK1	Q7L7X3	568	636	569	716	Alternative sequence	ID=VSP_043706;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TAOK1	Q7L7X3	716	787	569	716	Alternative sequence	ID=VSP_043706;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TAOK1	Q7L7X3	568	636	569	572	Alternative sequence	ID=VSP_015965;Note=In isoform 2. ELNE->VLMS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAOK1	Q7L7X3	568	636	573	1001	Alternative sequence	ID=VSP_015966;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAOK1	Q7L7X3	716	787	573	1001	Alternative sequence	ID=VSP_015966;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAOK1	Q7L7X3	44	68	57	57	Mutagenesis	Note=Abolishes kinase activity%2C ability to activate the MAPK8/JNK cascade and cleavage by caspase-3 (CASP3). K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16407310;Dbxref=PMID:16407310
TAOK1	Q7L7X3	150	187	169	169	Mutagenesis	Note=Loss of serine/threonine-protein kinase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17396146;Dbxref=PMID:17396146
TAOK1	Q7L7X3	333	401	376	376	Mutagenesis	Note=Does not abolish cleavage by caspase-3 (CASP3). D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16407310;Dbxref=PMID:16407310
TAOK1	Q7L7X3	716	787	785	785	Mutagenesis	Note=Abolishes phosphorylation by ATM%3B when associated with A-643 and A-990. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17396146;Dbxref=PMID:17396146
TBC1D2B	Q9UPU7	490	527	1	963	Chain	ID=PRO_0000315713;Note=TBC1 domain family member 2B
TBC1D2B	Q9UPU7	490	527	337	535	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TBC1D2B	Q9UPU7	490	527	1	548	Alternative sequence	ID=VSP_030666;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TUBE1	Q9UJT0	318	364	1	475	Chain	ID=PRO_0000048486;Note=Tubulin epsilon chain
TUBE1	Q9UJT0	271	317	1	475	Chain	ID=PRO_0000048486;Note=Tubulin epsilon chain
TGFB1	P01137	211	237	30	278	Chain	ID=PRO_0000033762;Note=Latency-associated peptide;Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:2982829,ECO:0000305|PubMed:3162913,ECO:0000305|PubMed:7737999,ECO:0000305|PubMed:8471846;Dbxref=PMID:2982829,PMID:3162913,PMID:7737999,PMID:8471846
TGFB1	P01137	211	237	75	271	Region	Note=Arm domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07200
TGFB1	P01137	211	237	226	252	Region	Note=Bowtie tail;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28117447;Dbxref=PMID:28117447
TGFB1	P01137	211	237	223	223	Disulfide bond	Note=Interchain (with C-225);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5FFO,ECO:0000244|PDB:5VQP,ECO:0000269|PubMed:28117447,ECO:0000269|PubMed:29109152;Dbxref=PMID:28117447,PMID:29109152
TGFB1	P01137	211	237	225	225	Disulfide bond	Note=Interchain (with C-223);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:5FFO,ECO:0000244|PDB:5VQP,ECO:0000269|PubMed:28117447,ECO:0000269|PubMed:29109152;Dbxref=PMID:28117447,PMID:29109152
TGFB1	P01137	211	237	218	218	Natural variant	ID=VAR_017608;Note=In CAEND%3B higher levels of active TGF-beta-1 in the culture medium%3B enhances osteoclast formation in vitro. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10973241,ECO:0000269|PubMed:11062463,ECO:0000269|PubMed:12493741,ECO:0000269|PubMed:12843182;Dbxref=PMID:10973241,PMID:11062463,PMID:12493741,PMID:12843182
TGFB1	P01137	211	237	218	218	Natural variant	ID=VAR_017609;Note=In CAEND. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10973241;Dbxref=PMID:10973241
TGFB1	P01137	211	237	222	222	Natural variant	ID=VAR_017610;Note=In CAEND%3B sporadic case%3B higher levels of active TGF-beta-1 in the culture medium. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12493741;Dbxref=PMID:12493741
TGFB1	P01137	211	237	223	223	Natural variant	ID=VAR_067303;Note=In CAEND. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15103729;Dbxref=PMID:15103729
TGFB1	P01137	211	237	223	223	Natural variant	ID=VAR_067304;Note=In CAEND. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15103729;Dbxref=PMID:15103729
TGFB1	P01137	211	237	225	225	Natural variant	ID=VAR_017611;Note=In CAEND%3B higher levels of active TGF-beta-1 in the culture medium. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10973241,ECO:0000269|PubMed:11062463,ECO:0000269|PubMed:12493741;Dbxref=PMID:10973241,PMID:11062463,PMID:12493741
TGFB1	P01137	211	237	232	236	Mutagenesis	Note=Strongly inhibits integrin-binding and activation of TGF-beta-1. LQVDI->GQGDG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28117447;Dbxref=PMID:28117447
TGFB1	P01137	211	237	234	236	Mutagenesis	Note=Strongly inhibits integrin-binding and activation of TGF-beta-1. VDI->GDG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28117447;Dbxref=PMID:28117447
TGFB1	P01137	211	237	237	237	Mutagenesis	Note=Does not affect integrin-binding or activation of TGF-beta-1. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28117447;Dbxref=PMID:28117447
TGFB1	P01137	211	237	213	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VQP
TGFB1	P01137	211	237	231	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VQP
THG1L	Q9NWX6	209	245	1	298	Chain	ID=PRO_0000284984;Note=Probable tRNA(His) guanylyltransferase
THG1L	Q9NWX6	209	245	232	232	Natural variant	ID=VAR_031871;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.5,ECO:0000269|Ref.6;Dbxref=dbSNP:rs2270812,PMID:14702039,PMID:15489334
THG1L	Q9NWX6	209	245	216	216	Mutagenesis	Note=Reduces activity by 98.5%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21059936;Dbxref=PMID:21059936
THG1L	Q9NWX6	209	245	227	227	Mutagenesis	Note=Loss of enzyme activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21059936;Dbxref=PMID:21059936
THG1L	Q9NWX6	209	245	213	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OTD
THG1L	Q9NWX6	209	245	228	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OTD
THG1L	Q9NWX6	209	245	233	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OTD
THG1L	Q9NWX6	209	245	239	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OTD
TXN	P10599	63	85	2	105	Chain	ID=PRO_0000120005;Note=Thioredoxin
TXN	P10599	43	63	2	105	Chain	ID=PRO_0000120005;Note=Thioredoxin
TXN	P10599	8	43	2	105	Chain	ID=PRO_0000120005;Note=Thioredoxin
TXN	P10599	63	85	2	105	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TXN	P10599	43	63	2	105	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TXN	P10599	8	43	2	105	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TXN	P10599	8	43	32	32	Active site	Note=Nucleophile
TXN	P10599	8	43	35	35	Active site	Note=Nucleophile
TXN	P10599	8	43	26	26	Site	Note=Deprotonates C-terminal active site Cys
TXN	P10599	8	43	33	33	Site	Note=Contributes to redox potential value
TXN	P10599	8	43	34	34	Site	Note=Contributes to redox potential value
TXN	P10599	8	43	8	8	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10639
TXN	P10599	8	43	39	39	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TXN	P10599	43	63	62	62	Modified residue	Note=S-nitrosocysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17260951;Dbxref=PMID:17260951
TXN	P10599	63	85	69	69	Modified residue	Note=S-nitrosocysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17260951;Dbxref=PMID:17260951
TXN	P10599	63	85	73	73	Modified residue	Note=S-nitrosocysteine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16408020,ECO:0000269|PubMed:17606900;Dbxref=PMID:16408020,PMID:17606900
TXN	P10599	8	43	32	35	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00691,ECO:0000269|PubMed:17260951,ECO:0000269|PubMed:2001356;Dbxref=PMID:17260951,PMID:2001356
TXN	P10599	63	85	73	73	Disulfide bond	Note=Interchain%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17260951;Dbxref=PMID:17260951
TXN	P10599	63	85	44	63	Alternative sequence	ID=VSP_045607;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.13
TXN	P10599	43	63	44	63	Alternative sequence	ID=VSP_045607;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.13
TXN	P10599	8	43	32	32	Mutagenesis	Note=Loses its reducing activity%2C interaction with APEX1 and transcription activation%3B when associated with S-35. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9108029;Dbxref=PMID:9108029
TXN	P10599	8	43	35	35	Mutagenesis	Note=Loses its reducing activity%2C interaction with APEX1 and transcription activation%3B when associated with S-32. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9108029;Dbxref=PMID:9108029
TXN	P10599	43	63	60	60	Mutagenesis	Note=Loss of pH-dependence of dimerization. D->N
TXN	P10599	43	63	62	62	Mutagenesis	Note=Retains its reducing activity. Retains interaction with APEX1 and transcription activation%3B when associated with S-69 and S-73. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9108029;Dbxref=PMID:9108029
TXN	P10599	63	85	69	69	Mutagenesis	Note=No effect on reducing activity%2C interaction with APEX1 and on S-nitrosylation of C-73. Retains interaction with APEX1 and transcription activation%3B when associated with S-62 and S-73. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17606900,ECO:0000269|PubMed:9108029;Dbxref=PMID:17606900,PMID:9108029
TXN	P10599	63	85	70	70	Mutagenesis	Note=Strongly reduced interaction with CASP3%3B when associated with A-72. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17606900;Dbxref=PMID:17606900
TXN	P10599	63	85	72	72	Mutagenesis	Note=Strongly reduced interaction with CASP3%3B when associated with A-70. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17606900;Dbxref=PMID:17606900
TXN	P10599	63	85	73	73	Mutagenesis	Note=Strongly reduced S-nitrosylation of CASP3. C->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16408020,ECO:0000269|PubMed:17606900,ECO:0000269|PubMed:9108029;Dbxref=PMID:16408020,PMID:17606900,PMID:9108029
TXN	P10599	63	85	73	73	Mutagenesis	Note=Loss of nitrosylation%2C and loss of S-nitrosylating activity towards CASP3. Retains interaction with APEX1 and transcription activation%3B when associated with S-62 and S-69. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16408020,ECO:0000269|PubMed:17606900,ECO:0000269|PubMed:9108029;Dbxref=PMID:16408020,PMID:17606900,PMID:9108029
TXN	P10599	63	85	73	73	Mutagenesis	Note=Retains its reducing activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16408020,ECO:0000269|PubMed:17606900,ECO:0000269|PubMed:9108029;Dbxref=PMID:16408020,PMID:17606900,PMID:9108029
TXN	P10599	8	43	39	39	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TXN	P10599	8	43	39	39	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TXN	P10599	63	85	74	74	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
TXN	P10599	63	85	74	74	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
TXN	P10599	8	43	8	17	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	8	43	18	20	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	8	43	23	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	8	43	30	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TRX
TXN	P10599	43	63	33	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	8	43	33	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	43	63	49	51	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QFB
TXN	P10599	43	63	52	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	43	63	59	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	63	85	63	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	43	63	63	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	63	85	73	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
TXN	P10599	63	85	84	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OO4
THOC6	Q86W42	233	270	1	341	Chain	ID=PRO_0000233158;Note=THO complex subunit 6 homolog
THOC6	Q86W42	270	315	1	341	Chain	ID=PRO_0000233158;Note=THO complex subunit 6 homolog
THOC6	Q86W42	233	270	215	254	Repeat	Note=WD 5
THOC6	Q86W42	233	270	256	293	Repeat	Note=WD 6
THOC6	Q86W42	270	315	256	293	Repeat	Note=WD 6
THOC6	Q86W42	270	315	295	339	Repeat	Note=WD 7
THOC6	Q86W42	270	315	271	315	Alternative sequence	ID=VSP_018078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
THYN1	Q9P016	128	160	1	225	Chain	ID=PRO_0000262564;Note=Thymocyte nuclear protein 1
THYN1	Q9P016	97	128	1	225	Chain	ID=PRO_0000262564;Note=Thymocyte nuclear protein 1
THYN1	Q9P016	128	160	1	225	Chain	ID=PRO_0000262564;Note=Thymocyte nuclear protein 1
THYN1	Q9P016	97	128	1	225	Chain	ID=PRO_0000262564;Note=Thymocyte nuclear protein 1
THYN1	Q9P016	128	160	1	225	Chain	ID=PRO_0000262564;Note=Thymocyte nuclear protein 1
THYN1	Q9P016	97	128	1	225	Chain	ID=PRO_0000262564;Note=Thymocyte nuclear protein 1
THYN1	Q9P016	97	128	96	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	96	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	96	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	110	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	110	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	110	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	122	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	122	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	122	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	122	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	122	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	97	128	122	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	137	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	159	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	159	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THYN1	Q9P016	128	160	159	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EOP
THOC1	Q96FV9	435	456	1	657	Chain	ID=PRO_0000072520;Note=THO complex subunit 1
THOC1	Q96FV9	362	379	1	657	Chain	ID=PRO_0000072520;Note=THO complex subunit 1
THOC1	Q96FV9	262	306	1	657	Chain	ID=PRO_0000072520;Note=THO complex subunit 1
THOC1	Q96FV9	262	306	300	300	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
THOC1	Q96FV9	362	379	363	377	Alternative sequence	ID=VSP_038073;Note=In isoform 2. LLSENPPDGERFSKM->VSSTRNKPMIEKMEI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15358532;Dbxref=PMID:15358532
THOC1	Q96FV9	435	456	378	657	Alternative sequence	ID=VSP_038074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15358532;Dbxref=PMID:15358532
THOC1	Q96FV9	362	379	378	657	Alternative sequence	ID=VSP_038074;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15358532;Dbxref=PMID:15358532
TUBB2A	Q13885	55	92	1	445	Chain	ID=PRO_0000262648;Note=Tubulin beta-2A chain
TUBB2A	Q13885	55	92	58	58	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07437
TUBB2A	Q13885	55	92	58	58	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P99024
TUBB2A	Q13885	55	92	58	58	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07437
TUBB2A	Q13885	55	92	62	62	Natural variant	ID=VAR_036197;Note=In a colorectal cancer sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs774124807,PMID:16959974
TECTA	O75443	2083	2122	23	2091	Chain	ID=PRO_0000041735;Note=Alpha-tectorin
TECTA	O75443	2083	2122	23	2091	Chain	ID=PRO_0000041735;Note=Alpha-tectorin
TECTA	O75443	2083	2122	2092	2155	Propeptide	ID=PRO_0000041736;Note=Removed in mature form;Ontology_term=ECO:0000255;evidence=ECO:0000255
TECTA	O75443	2083	2122	2092	2155	Propeptide	ID=PRO_0000041736;Note=Removed in mature form;Ontology_term=ECO:0000255;evidence=ECO:0000255
TECTA	O75443	2083	2122	2091	2091	Lipidation	Note=GPI-anchor amidated asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TECTA	O75443	2083	2122	2091	2091	Lipidation	Note=GPI-anchor amidated asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TECTA	O75443	2083	2122	2100	2100	Natural variant	ID=VAR_018978;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10987647;Dbxref=PMID:10987647
TECTA	O75443	2083	2122	2100	2100	Natural variant	ID=VAR_018978;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10987647;Dbxref=PMID:10987647
TEC	P42680	224	245	1	631	Chain	ID=PRO_0000088170;Note=Tyrosine-protein kinase Tec
TEC	P42680	46	81	1	631	Chain	ID=PRO_0000088170;Note=Tyrosine-protein kinase Tec
TEC	P42680	46	81	4	111	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
TEC	P42680	224	245	179	239	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TEC	P42680	224	245	228	228	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
TEC	P42680	46	81	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TEC	P42680	46	81	53	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TEC	P42680	46	81	56	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TEC	P42680	46	81	61	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TEC	P42680	46	81	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TEC	P42680	46	81	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TEC	P42680	46	81	78	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL
TCTN1	Q2MV58	326	368	23	587	Chain	ID=PRO_0000229796;Note=Tectonic-1
TCTN1	Q2MV58	326	368	330	330	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCTN1	Q2MV58	326	368	341	341	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEX11	Q8IYF3	665	704	1	940	Chain	ID=PRO_0000296955;Note=Testis-expressed protein 11
TEX11	Q8IYF3	665	704	1	940	Chain	ID=PRO_0000296955;Note=Testis-expressed protein 11
TEX11	Q8IYF3	665	704	698	698	Natural variant	ID=VAR_073890;Note=In SPGFX2. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25970010;Dbxref=dbSNP:rs140984555,PMID:25970010
TEX11	Q8IYF3	665	704	698	698	Natural variant	ID=VAR_073890;Note=In SPGFX2. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25970010;Dbxref=dbSNP:rs140984555,PMID:25970010
TGM5	O43548	63	145	2	720	Chain	ID=PRO_0000213713;Note=Protein-glutamine gamma-glutamyltransferase 5
TGM5	O43548	63	145	64	145	Alternative sequence	ID=VSP_006415;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9452468;Dbxref=PMID:9452468
TGM5	O43548	63	145	67	67	Natural variant	ID=VAR_013248;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11390390;Dbxref=dbSNP:rs757598618,PMID:11390390
TGM5	O43548	63	145	109	109	Natural variant	ID=VAR_025848;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16380904;Dbxref=dbSNP:rs113463533,PMID:16380904
TGM5	O43548	63	145	113	113	Natural variant	ID=VAR_025849;Note=In PSS2%3B completely abolishes the enzyme activity. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16380904;Dbxref=dbSNP:rs112292549,PMID:16380904
THOP1	P52888	126	162	1	689	Chain	ID=PRO_0000078153;Note=Thimet oligopeptidase
THOP1	P52888	126	162	1	489	Alternative sequence	ID=VSP_056494;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
THOP1	P52888	126	162	116	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O36
THOP1	P52888	126	162	136	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O36
THOP1	P52888	126	162	152	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O36
THOP1	P52888	126	162	158	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O36
TIMM17A	Q99595	63	106	1	171	Chain	ID=PRO_0000210284;Note=Mitochondrial import inner membrane translocase subunit Tim17-A
TIMM17A	Q99595	106	143	1	171	Chain	ID=PRO_0000210284;Note=Mitochondrial import inner membrane translocase subunit Tim17-A
TIMM17A	Q99595	63	106	63	77	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMM17A	Q99595	106	143	113	133	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMM17A	Q99595	63	106	9	78	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39515
TIMM17A	Q99595	106	143	113	113	Natural variant	ID=VAR_052305;Note=V->I;Dbxref=dbSNP:rs4648
TIA1	P31483	92	103	1	386	Chain	ID=PRO_0000031031;Note=Nucleolysin TIA-1 isoform p40
TIA1	P31483	92	103	93	104	Alternative sequence	ID=VSP_005892;Note=In isoform Short. SSTVVSTQRSQD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1934064;Dbxref=PMID:1934064
TIMM9	Q9Y5J7	13	45	2	89	Chain	ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9
TIMM9	Q9Y5J7	13	45	2	89	Chain	ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9
TIMM9	Q9Y5J7	13	45	2	89	Chain	ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9
TIMM9	Q9Y5J7	13	45	2	89	Chain	ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9
TIMM9	Q9Y5J7	13	45	28	52	Motif	Note=Twin CX3C motif
TIMM9	Q9Y5J7	13	45	28	52	Motif	Note=Twin CX3C motif
TIMM9	Q9Y5J7	13	45	28	52	Motif	Note=Twin CX3C motif
TIMM9	Q9Y5J7	13	45	28	52	Motif	Note=Twin CX3C motif
TIMM9	Q9Y5J7	13	45	28	52	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	28	52	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	28	52	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	28	52	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	32	48	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	32	48	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	32	48	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	32	48	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659
TIMM9	Q9Y5J7	13	45	15	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	15	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	15	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	15	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	37	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	37	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	37	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	37	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	43	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	43	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	43	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TIMM9	Q9Y5J7	13	45	43	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK
TAC4	Q86UU9	83	103	82	95	Peptide	ID=PRO_5000063347;Note=Endokinin-C
TAC4	Q86UU9	83	103	98	113	Propeptide	ID=PRO_0000320013;Ontology_term=ECO:0000250;evidence=ECO:0000250
TAC4	Q86UU9	83	103	95	95	Modified residue	Note=Leucine amide;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968
TAC4	Q86UU9	83	103	73	83	Alternative sequence	ID=VSP_052677;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968
TAC4	Q86UU9	83	103	75	105	Alternative sequence	ID=VSP_052680;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968
TAC4	Q86UU9	83	103	84	103	Alternative sequence	ID=VSP_052681;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968
TLK1	Q9UKI8	503	532	1	766	Chain	ID=PRO_0000086752;Note=Serine/threonine-protein kinase tousled-like 1
TLK1	Q9UKI8	327	389	1	766	Chain	ID=PRO_0000086752;Note=Serine/threonine-protein kinase tousled-like 1
TLK1	Q9UKI8	244	281	1	766	Chain	ID=PRO_0000086752;Note=Serine/threonine-protein kinase tousled-like 1
TLK1	Q9UKI8	213	244	1	766	Chain	ID=PRO_0000086752;Note=Serine/threonine-protein kinase tousled-like 1
TLK1	Q9UKI8	86	110	1	766	Chain	ID=PRO_0000086752;Note=Serine/threonine-protein kinase tousled-like 1
TLK1	Q9UKI8	503	532	456	734	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TLK1	Q9UKI8	244	281	230	281	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TLK1	Q9UKI8	213	244	230	281	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TLK1	Q9UKI8	213	244	1	217	Alternative sequence	ID=VSP_050570;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10588641;Dbxref=PMID:10588641
TLK1	Q9UKI8	86	110	1	217	Alternative sequence	ID=VSP_050570;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10588641;Dbxref=PMID:10588641
TLK1	Q9UKI8	86	110	15	110	Alternative sequence	ID=VSP_043506;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TLK1	Q9UKI8	86	110	88	88	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLK1	Q9UKI8	86	110	102	102	Sequence conflict	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLK1	Q9UKI8	213	244	230	230	Sequence conflict	Note=Q->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLK1	Q9UKI8	244	281	261	261	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAF6L	Q9Y6J9	177	202	1	622	Chain	ID=PRO_0000118879;Note=TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
TAF7L	Q5H9L4	316	390	1	462	Chain	ID=PRO_0000307861;Note=Transcription initiation factor TFIID subunit 7-like
TAF7L	Q5H9L4	316	390	342	462	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF7L	Q5H9L4	316	390	336	377	Compositional bias	Note=Glu-rich
TAF7L	Q5H9L4	316	390	317	390	Alternative sequence	ID=VSP_028848;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAF7L	Q5H9L4	316	390	350	351	Natural variant	ID=VAR_036698;Note=Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11279525,ECO:0000269|PubMed:16597641,ECO:0000269|PubMed:17714218;Dbxref=PMID:11279525,PMID:16597641,PMID:17714218
TREML1	Q86YW5	14	125	1	15	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TREML1	Q86YW5	14	125	16	311	Chain	ID=PRO_0000253855;Note=Trem-like transcript 1 protein
TREML1	Q86YW5	14	125	16	162	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TREML1	Q86YW5	14	125	16	121	Domain	Note=Ig-like V-type
TREML1	Q86YW5	14	125	38	104	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478
TREML1	Q86YW5	14	125	52	59	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478
TREML1	Q86YW5	14	125	15	125	Alternative sequence	ID=VSP_021124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TREML1	Q86YW5	14	125	24	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	34	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	42	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	47	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	58	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	70	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	77	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	100	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TREML1	Q86YW5	14	125	111	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG
TANC1	Q9C0D5	20	86	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	86	121	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	227	315	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	315	356	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	873	914	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	993	1055	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	1301	1350	1	1861	Chain	ID=PRO_0000316959;Note=Protein TANC1
TANC1	Q9C0D5	873	914	896	928	Repeat	Note=ANK 1
TANC1	Q9C0D5	993	1055	967	996	Repeat	Note=ANK 3
TANC1	Q9C0D5	993	1055	1000	1029	Repeat	Note=ANK 4
TANC1	Q9C0D5	993	1055	1040	1069	Repeat	Note=ANK 5
TANC1	Q9C0D5	1301	1350	1289	1322	Repeat	Note=TPR 1
TANC1	Q9C0D5	1301	1350	1336	1369	Repeat	Note=TPR 2
TANC1	Q9C0D5	227	315	170	243	Compositional bias	Note=Ser-rich
TANC1	Q9C0D5	20	86	63	63	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TANC1	Q9C0D5	20	86	66	66	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TANC1	Q9C0D5	20	86	67	67	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TANC1	Q9C0D5	227	315	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TANC1	Q9C0D5	227	315	122	227	Alternative sequence	ID=VSP_030828;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TANC1	Q9C0D5	20	86	30	30	Natural variant	ID=VAR_061022;Note=P->S;Dbxref=dbSNP:rs34588551
TANC1	Q9C0D5	227	315	251	251	Natural variant	ID=VAR_038435;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214970,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12466551,PMID:11214970,PMID:15489334
TAF9B	Q9HBM6	160	197	1	251	Chain	ID=PRO_0000118891;Note=Transcription initiation factor TFIID subunit 9B
TAF9B	Q9HBM6	90	135	1	251	Chain	ID=PRO_0000118891;Note=Transcription initiation factor TFIID subunit 9B
TAF9B	Q9HBM6	160	197	174	174	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
TAF9B	Q9HBM6	160	197	177	177	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TCOF1	Q13428	213	290	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	290	361	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	496	568	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	826	886	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1061	1099	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1261	1448	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	213	290	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	290	361	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	496	568	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	826	886	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1061	1099	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1260	1447	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1261	1448	1362	1366	Compositional bias	Note=Poly-Lys
TCOF1	Q13428	1260	1447	1362	1366	Compositional bias	Note=Poly-Lys
TCOF1	Q13428	213	290	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
TCOF1	Q13428	213	290	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
TCOF1	Q13428	213	290	249	249	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:19690332,PMID:20068231,PMID:23186163
TCOF1	Q13428	213	290	249	249	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:19690332,PMID:20068231,PMID:23186163
TCOF1	Q13428	290	361	296	296	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	290	361	296	296	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	290	361	310	310	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	290	361	310	310	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	290	361	313	313	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	290	361	313	313	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	290	361	316	316	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TCOF1	Q13428	290	361	316	316	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TCOF1	Q13428	290	361	322	322	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	290	361	322	322	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	496	568	503	503	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	496	568	503	503	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	496	568	533	533	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	496	568	533	533	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	826	886	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	870	870	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	870	870	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	871	871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	871	871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	875	875	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	875	875	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	877	877	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	877	877	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	1261	1448	1350	1350	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TCOF1	Q13428	1260	1447	1350	1350	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TCOF1	Q13428	1261	1448	1358	1358	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	1260	1447	1358	1358	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	1261	1448	1376	1376	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
TCOF1	Q13428	1260	1447	1376	1376	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
TCOF1	Q13428	1261	1448	1378	1378	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	1260	1447	1378	1378	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	1261	1448	1407	1407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TCOF1	Q13428	1260	1447	1407	1407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TCOF1	Q13428	1261	1448	1410	1410	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TCOF1	Q13428	1260	1447	1410	1410	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TCOF1	Q13428	1261	1448	1414	1414	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	1260	1447	1414	1414	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	496	568	507	507	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TCOF1	Q13428	496	568	507	507	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TCOF1	Q13428	1261	1448	1414	1414	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
TCOF1	Q13428	1260	1447	1414	1414	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
TCOF1	Q13428	213	290	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	290	361	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	213	290	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	290	361	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	1061	1099	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1261	1448	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1061	1099	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1260	1447	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1061	1099	1062	1099	Alternative sequence	ID=VSP_040382;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCOF1	Q13428	1061	1099	1062	1099	Alternative sequence	ID=VSP_040382;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCOF1	Q13428	213	290	221	221	Natural variant	ID=VAR_057002;Note=A->P;Dbxref=dbSNP:rs11541811
TCOF1	Q13428	213	290	221	221	Natural variant	ID=VAR_057002;Note=A->P;Dbxref=dbSNP:rs11541811
TCOF1	Q13428	496	568	516	516	Natural variant	ID=VAR_005631;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs138645438,PMID:9042910
TCOF1	Q13428	496	568	516	516	Natural variant	ID=VAR_005631;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs138645438,PMID:9042910
TCOF1	Q13428	1261	1448	1280	1280	Natural variant	ID=VAR_059730;Note=G->R;Dbxref=dbSNP:rs11541812
TCOF1	Q13428	1260	1447	1280	1280	Natural variant	ID=VAR_059730;Note=G->R;Dbxref=dbSNP:rs11541812
TCOF1	Q13428	1261	1448	1390	1390	Natural variant	ID=VAR_005633;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs15251,PMID:9042910
TCOF1	Q13428	1260	1447	1390	1390	Natural variant	ID=VAR_005633;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs15251,PMID:9042910
TCOF1	Q13428	1261	1448	1431	1431	Natural variant	ID=VAR_061709;Note=G->A;Dbxref=dbSNP:rs45491898
TCOF1	Q13428	1260	1447	1431	1431	Natural variant	ID=VAR_061709;Note=G->A;Dbxref=dbSNP:rs45491898
TCOF1	Q13428	1261	1448	1432	1432	Natural variant	ID=VAR_005634;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs151344580,PMID:9042910
TCOF1	Q13428	1260	1447	1432	1432	Natural variant	ID=VAR_005634;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs151344580,PMID:9042910
TCOF1	Q13428	1261	1448	1271	1271	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	1260	1447	1271	1271	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	1261	1448	1389	1389	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	1260	1447	1389	1389	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCERG1	O14776	378	399	1	1098	Chain	ID=PRO_0000076063;Note=Transcription elongation regulator 1
TCERG1	O14776	849	910	1	1098	Chain	ID=PRO_0000076063;Note=Transcription elongation regulator 1
TCERG1	O14776	849	910	896	952	Domain	Note=FF 4
TCERG1	O14776	849	910	844	906	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCERG1	O14776	378	399	328	378	Compositional bias	Note=Pro-rich
TCERG1	O14776	378	399	379	399	Alternative sequence	ID=VSP_026933;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
TCERG1	O14776	849	910	888	890	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DOF
TCERG1	O14776	849	910	895	910	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FQG
PTGES3	Q15185	125	146	1	160	Chain	ID=PRO_0000218952;Note=Prostaglandin E synthase 3
PTGES3	Q15185	95	125	1	160	Chain	ID=PRO_0000218952;Note=Prostaglandin E synthase 3
PTGES3	Q15185	62	95	1	160	Chain	ID=PRO_0000218952;Note=Prostaglandin E synthase 3
PTGES3	Q15185	62	95	1	90	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
PTGES3	Q15185	125	146	108	160	Compositional bias	Note=Asp/Glu-rich
PTGES3	Q15185	95	125	108	160	Compositional bias	Note=Asp/Glu-rich
PTGES3	Q15185	62	95	85	85	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
PTGES3	Q15185	95	125	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R0Q7
PTGES3	Q15185	95	125	113	113	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16807684,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19367720,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|Ref.6;Dbxref=PMID:16807684,PMID:17081983,PMID:17487921,PMID:18088087,PMID:18318008,PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
PTGES3	Q15185	95	125	118	118	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231;Dbxref=PMID:17081983,PMID:20068231
PTGES3	Q15185	62	95	65	65	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PTGES3	Q15185	95	125	63	95	Alternative sequence	ID=VSP_055363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTGES3	Q15185	62	95	63	95	Alternative sequence	ID=VSP_055363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTGES3	Q15185	125	146	96	125	Alternative sequence	ID=VSP_055364;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTGES3	Q15185	95	125	96	125	Alternative sequence	ID=VSP_055364;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTGES3	Q15185	125	146	126	146	Alternative sequence	ID=VSP_055365;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTGES3	Q15185	62	95	59	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EJF
PTGES3	Q15185	62	95	73	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EJF
PTGES3	Q15185	62	95	87	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EJF
PTGES3	Q15185	95	125	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EJF
PTGES3	Q15185	95	125	103	105	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EJF
TEFM	Q96QE5	165	215	36	360	Chain	ID=PRO_0000406329;Note=Transcription elongation factor%2C mitochondrial
TEFM	Q96QE5	165	215	166	171	Alternative sequence	ID=VSP_040808;Note=In isoform 2. AVNSII->NCLGSP;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TEFM	Q96QE5	165	215	172	360	Alternative sequence	ID=VSP_040809;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TEFM	Q96QE5	165	215	161	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OL8
TEFM	Q96QE5	165	215	169	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OL8
TEFM	Q96QE5	165	215	177	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OL8
TEFM	Q96QE5	165	215	190	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OL8
TEFM	Q96QE5	165	215	202	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OL8
TEFM	Q96QE5	165	215	209	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OL8
TCTN2	Q96GX1	366	411	26	697	Chain	ID=PRO_0000229798;Note=Tectonic-2
TCTN2	Q96GX1	411	437	26	697	Chain	ID=PRO_0000229798;Note=Tectonic-2
TCTN2	Q96GX1	366	411	26	668	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TCTN2	Q96GX1	411	437	26	668	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TCTN2	Q96GX1	366	411	391	391	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM4	Q6N022	361	418	1	2769	Chain	ID=PRO_0000259508;Note=Teneurin-4
TENM4	Q6N022	250	282	1	2769	Chain	ID=PRO_0000259508;Note=Teneurin-4
TENM4	Q6N022	250	282	1	345	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM4	Q6N022	361	418	346	366	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM4	Q6N022	361	418	367	2769	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TENM4	Q6N022	250	282	1	341	Domain	Note=Teneurin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00694
TENM4	Q6N022	361	418	396	396	Natural variant	ID=VAR_060130;Note=V->I;Dbxref=dbSNP:rs3812723
TEX10	Q9NXF1	734	761	1	929	Chain	ID=PRO_0000072491;Note=Testis-expressed protein 10
TEX14	Q8IWB6	1318	1341	1	1497	Chain	ID=PRO_0000246995;Note=Inactive serine/threonine-protein kinase TEX14
TEX14	Q8IWB6	1063	1103	1	1497	Chain	ID=PRO_0000246995;Note=Inactive serine/threonine-protein kinase TEX14
TEX14	Q8IWB6	262	299	1	1497	Chain	ID=PRO_0000246995;Note=Inactive serine/threonine-protein kinase TEX14
TEX14	Q8IWB6	262	299	227	518	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TEX14	Q8IWB6	262	299	273	273	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TEX14	Q8IWB6	1063	1103	1064	1103	Alternative sequence	ID=VSP_019869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11279525,ECO:0000303|PubMed:17974005;Dbxref=PMID:11279525,PMID:17974005
TEX14	Q8IWB6	1318	1341	1326	1326	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TEX26	Q8N6G2	156	215	1	289	Chain	ID=PRO_0000263723;Note=Testis-expressed protein 26
TEX26	Q8N6G2	215	269	1	289	Chain	ID=PRO_0000263723;Note=Testis-expressed protein 26
TEX26	Q8N6G2	215	269	231	231	Natural variant	ID=VAR_029615;Note=K->N;Dbxref=dbSNP:rs9533168
GTF2B	Q00403	178	272	1	316	Chain	ID=PRO_0000119293;Note=Transcription initiation factor IIB
GTF2B	Q00403	178	272	124	200	Repeat	Note=1
GTF2B	Q00403	178	272	218	294	Repeat	Note=2
GTF2B	Q00403	178	272	189	193	Region	Note=Core promoter DNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10619841;Dbxref=PMID:10619841
GTF2B	Q00403	178	272	244	316	Region	Note=Necessary for TATA box-bound TBP complex formation;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8515820,ECO:0000269|PubMed:8516311;Dbxref=PMID:8515820,PMID:8516311
GTF2B	Q00403	178	272	249	252	Region	Note=Core promoter DNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7675079;Dbxref=PMID:7675079
GTF2B	Q00403	178	272	238	238	Modified residue	Note=N6-acetyllysine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12931194;Dbxref=PMID:12931194
GTF2B	Q00403	178	272	185	185	Mutagenesis	Note=Reduces interaction with SSU72%3B when associated with E-193 or E-200. Inhibits interaction with VP16%3B when associated with E-193. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription%3B when associated with E-193. R->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29158257,ECO:0000269|PubMed:8515819;Dbxref=PMID:29158257,PMID:8515819
GTF2B	Q00403	178	272	185	185	Mutagenesis	Note=Reduces interaction with VP16%3B when associated with L-189. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8515819;Dbxref=PMID:8515819
GTF2B	Q00403	178	272	189	189	Mutagenesis	Note=Inhibits interaction with SSU72%3B when associated with E-193. Reduces interaction with SSU72%3B when associated with E-200. Inhibits interaction with VP16%3B when associated with E-200. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription%3B when associated with E-200. K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29158257,ECO:0000269|PubMed:8515819;Dbxref=PMID:29158257,PMID:8515819
GTF2B	Q00403	178	272	189	189	Mutagenesis	Note=Reduces interaction with VP16%3B when associated with L-185. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8515819;Dbxref=PMID:8515819
GTF2B	Q00403	178	272	193	193	Mutagenesis	Note=Inhibits interaction with SSU72%3B when associated with E-185 or E-189. Inhibits interaction with VP16%3B when associated with E-185. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription%3B when associated with E-185. R->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29158257,ECO:0000269|PubMed:8515819;Dbxref=PMID:29158257,PMID:8515819
GTF2B	Q00403	178	272	196	196	Mutagenesis	Note=Reduces interaction with VP16%3B when associated with L-200. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8515819;Dbxref=PMID:8515819
GTF2B	Q00403	178	272	200	208	Mutagenesis	Note=Reduces the formation of the TATA box-bound TBP ternary complex. KALETSVDL->GSGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29158257;Dbxref=PMID:29158257
GTF2B	Q00403	178	272	200	200	Mutagenesis	Note=Reduces interaction with SSU72%3B when associated with E-185 or E-189. Inhibits interaction with VP16%3B when associated with E-189. Inhibits RNA pol II transcription activation induced by VP16 but does not affect basal transcription%3B when associated with E-189. K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29158257,ECO:0000269|PubMed:8515819;Dbxref=PMID:29158257,PMID:8515819
GTF2B	Q00403	178	272	200	200	Mutagenesis	Note=Reduces the formation of the TATA box-bound TBP ternary complex. K->KGSGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29158257;Dbxref=PMID:29158257
GTF2B	Q00403	178	272	200	200	Mutagenesis	Note=Reduces interaction with VP16%3B when associated with L-196. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8515819;Dbxref=PMID:8515819
GTF2B	Q00403	178	272	208	208	Mutagenesis	Note=Does not inhibit the formation of the TATA box-bound TBP ternary complex. L->LGSGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29158257;Dbxref=PMID:29158257
GTF2B	Q00403	178	272	238	238	Mutagenesis	Note=Abolishes autoacetylation%2C represses transcription activity%2C does not inhibit its association with chromatin to promoter-specific regions and decreases the association of GTF2F1 with chromatin to promoter-specific regions. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12931194;Dbxref=PMID:12931194
GTF2B	Q00403	178	272	247	247	Mutagenesis	Note=Inhibits interaction with TBP. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8516312;Dbxref=PMID:8516312
GTF2B	Q00403	178	272	177	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	184	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	188	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	212	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	226	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	250	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	265	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
GTF2B	Q00403	178	272	271	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1C9B
TRABD2A	Q86V40	361	444	20	505	Chain	ID=PRO_0000325807;Note=Metalloprotease TIKI1
TRABD2A	Q86V40	223	272	20	505	Chain	ID=PRO_0000325807;Note=Metalloprotease TIKI1
TRABD2A	Q86V40	361	444	20	477	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRABD2A	Q86V40	223	272	20	477	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRABD2A	Q86V40	223	272	229	229	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRABD2A	Q86V40	223	272	225	273	Alternative sequence	ID=VSP_038837;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRABD2A	Q86V40	361	444	428	428	Natural variant	ID=VAR_039921;Note=R->Q;Dbxref=dbSNP:rs2288352
TRABD2A	Q86V40	361	444	430	430	Natural variant	ID=VAR_039922;Note=P->L;Dbxref=dbSNP:rs1649292
TRIM24	O15164	568	626	1	1050	Chain	ID=PRO_0000056390;Note=Transcription intermediary factor 1-alpha
TRIM24	O15164	568	626	600	600	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIM24	O15164	568	626	608	608	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TAF5	Q15542	555	609	1	800	Chain	ID=PRO_0000051257;Note=Transcription initiation factor TFIID subunit 5
TAF5	Q15542	555	609	541	580	Repeat	Note=WD 2
TAF5	Q15542	555	609	583	624	Repeat	Note=WD 3
TAF5	Q15542	555	609	556	610	Alternative sequence	ID=VSP_006787;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TAF6	P49848	486	552	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	428	486	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	361	386	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	300	361	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	240	266	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	151	191	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	132	151	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	486	552	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	428	486	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	361	386	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	300	361	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	240	266	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	151	191	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	132	151	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	486	552	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	428	486	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	361	386	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	300	361	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	240	266	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	151	191	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	132	151	1	677	Chain	ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6
TAF6	P49848	240	266	248	248	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	248	248	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	248	248	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	253	253	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	253	253	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	253	253	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	240	266	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801
TAF6	P49848	486	552	524	524	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TAF6	P49848	486	552	524	524	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TAF6	P49848	486	552	524	524	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TAF6	P49848	486	552	477	486	Alternative sequence	ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073
TAF6	P49848	428	486	477	486	Alternative sequence	ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073
TAF6	P49848	486	552	477	486	Alternative sequence	ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073
TAF6	P49848	428	486	477	486	Alternative sequence	ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073
TAF6	P49848	486	552	477	486	Alternative sequence	ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073
TAF6	P49848	428	486	477	486	Alternative sequence	ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073
TAF2	Q6P1X5	751	788	1	1199	Chain	ID=PRO_0000252424;Note=Transcription initiation factor TFIID subunit 2
TAF2	Q6P1X5	326	363	1	1199	Chain	ID=PRO_0000252424;Note=Transcription initiation factor TFIID subunit 2
TAF2	Q6P1X5	751	788	785	785	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ABI3BP	Q7Z7G0	799	869	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	776	799	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	629	655	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	602	629	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	582	602	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	433	458	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	386	408	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	361	386	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	336	361	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	33	93	29	1075	Chain	ID=PRO_0000022472;Note=Target of Nesh-SH3
ABI3BP	Q7Z7G0	799	869	840	933	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
ABI3BP	Q7Z7G0	629	655	419	756	Compositional bias	Note=Pro-rich
ABI3BP	Q7Z7G0	602	629	419	756	Compositional bias	Note=Pro-rich
ABI3BP	Q7Z7G0	582	602	419	756	Compositional bias	Note=Pro-rich
ABI3BP	Q7Z7G0	433	458	419	756	Compositional bias	Note=Pro-rich
ABI3BP	Q7Z7G0	33	93	44	44	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ABI3BP	Q7Z7G0	602	629	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	582	602	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	433	458	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	386	408	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	361	386	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	336	361	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	33	93	1	614	Alternative sequence	ID=VSP_010860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11501947,ECO:0000303|PubMed:14702039;Dbxref=PMID:11501947,PMID:14702039
ABI3BP	Q7Z7G0	33	93	1	316	Alternative sequence	ID=VSP_010862;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	433	458	317	530	Alternative sequence	ID=VSP_010865;Note=In isoform 4. ALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHT->MTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKVPQRTHRPHPKPKTTLSPEELQTELVPVTDLGPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	386	408	317	530	Alternative sequence	ID=VSP_010865;Note=In isoform 4. ALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHT->MTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKVPQRTHRPHPKPKTTLSPEELQTELVPVTDLGPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	361	386	317	530	Alternative sequence	ID=VSP_010865;Note=In isoform 4. ALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHT->MTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKVPQRTHRPHPKPKTTLSPEELQTELVPVTDLGPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	336	361	317	530	Alternative sequence	ID=VSP_010865;Note=In isoform 4. ALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHT->MTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKVPQRTHRPHPKPKTTLSPEELQTELVPVTDLGPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	433	458	317	446	Alternative sequence	ID=VSP_010863;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	386	408	317	446	Alternative sequence	ID=VSP_010863;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	361	386	317	446	Alternative sequence	ID=VSP_010863;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	336	361	317	446	Alternative sequence	ID=VSP_010863;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABI3BP	Q7Z7G0	433	458	447	531	Alternative sequence	ID=VSP_010864;Note=In isoform 3. IFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTK->MTESLPVSDVLESVTLSTESPKETIAPAKTDYVYPTAKAPLWPEEPKTEVVESITYVSEPPETTLETSPLPSQSITLPSPDEPQTE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TECRL	Q5HYJ1	95	110	1	363	Chain	ID=PRO_0000317713;Note=Trans-2%2C3-enoyl-CoA reductase-like
TECR	Q9NZ01	5	22	1	308	Chain	ID=PRO_0000213683;Note=Very-long-chain enoyl-CoA reductase
TECR	Q9NZ01	5	22	22	22	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TECR	Q9NZ01	5	22	20	170	Alternative sequence	ID=VSP_005957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9653160;Dbxref=PMID:9653160
TECR	Q9NZ01	5	22	4	13	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DZJ
TECR	Q9NZ01	5	22	18	23	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DZJ
GTF2H1	P32780	489	520	1	548	Chain	ID=PRO_0000119245;Note=General transcription factor IIH subunit 1
GTF2H1	P32780	489	520	1	548	Chain	ID=PRO_0000119245;Note=General transcription factor IIH subunit 1
GTF2H1	P32780	489	520	517	517	Natural variant	ID=VAR_014347;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs4150665
GTF2H1	P32780	489	520	517	517	Natural variant	ID=VAR_014347;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs4150665
GTF2H2	Q13888	216	252	1	395	Chain	ID=PRO_0000119248;Note=General transcription factor IIH subunit 2
GTF2H2	Q13888	86	103	1	395	Chain	ID=PRO_0000119248;Note=General transcription factor IIH subunit 2
GTF2H2	Q13888	216	252	1	395	Chain	ID=PRO_0000119248;Note=General transcription factor IIH subunit 2
GTF2H2	Q13888	86	103	1	395	Chain	ID=PRO_0000119248;Note=General transcription factor IIH subunit 2
GTF2H2	Q13888	216	252	60	236	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
GTF2H2	Q13888	86	103	60	236	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
GTF2H2	Q13888	216	252	60	236	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
GTF2H2	Q13888	86	103	60	236	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
GTF2H2	Q13888	86	103	95	95	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0JN27
GTF2H2	Q13888	86	103	95	95	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A0JN27
GTF2H2	Q13888	216	252	236	236	Natural variant	ID=VAR_011665;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9063743;Dbxref=dbSNP:rs201102513,PMID:9063743
GTF2H2	Q13888	216	252	236	236	Natural variant	ID=VAR_011665;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9063743;Dbxref=dbSNP:rs201102513,PMID:9063743
GTF2H3	Q13889	187	205	1	308	Chain	ID=PRO_0000119251;Note=General transcription factor IIH subunit 3
GTF2H3	Q13889	187	205	190	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O85
GTF2H3	Q13889	187	205	201	210	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O85
TFCP2L1	Q9NZI6	168	219	1	479	Chain	ID=PRO_0000228006;Note=Transcription factor CP2-like protein 1
TFCP2L1	Q9NZI6	168	219	21	260	Region	Note=CP2-like domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26906118;Dbxref=PMID:26906118
TGM2	P21980	63	144	2	687	Chain	ID=PRO_0000213707;Note=Protein-glutamine gamma-glutamyltransferase 2
TGM2	P21980	3	63	2	687	Chain	ID=PRO_0000213707;Note=Protein-glutamine gamma-glutamyltransferase 2
TGM2	P21980	3	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TGM2	P21980	63	144	76	76	Natural variant	ID=VAR_052553;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs41274720
TGM2	P21980	3	63	51	51	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
TGM2	P21980	3	63	7	11	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	14	20	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	24	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	28	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	39	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	55	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	3	63	55	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	69	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	73	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PYG
TGM2	P21980	63	144	89	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	97	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	113	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGM2	P21980	63	144	126	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q3Z
TGDS	O95455	51	74	1	350	Chain	ID=PRO_0000183250;Note=dTDP-D-glucose 4%2C6-dehydratase
TGM3	Q08188	362	444	2	467	Chain	ID=PRO_0000033652;Note=Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain
TGM3	Q08188	444	547	2	467	Chain	ID=PRO_0000033652;Note=Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain
TGM3	Q08188	444	547	468	693	Chain	ID=PRO_0000033653;Note=Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain
TGM3	Q08188	362	444	394	394	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11980702,ECO:0000269|PubMed:12679341;Dbxref=PMID:11980702,PMID:12679341
TGM3	Q08188	362	444	416	416	Metal binding	Note=Calcium 3%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11980702,ECO:0000269|PubMed:12679341;Dbxref=PMID:11980702,PMID:12679341
TGM3	Q08188	362	444	444	444	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11980702,ECO:0000269|PubMed:12679341;Dbxref=PMID:11980702,PMID:12679341
TGM3	Q08188	444	547	444	444	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11980702,ECO:0000269|PubMed:12679341;Dbxref=PMID:11980702,PMID:12679341
TGM3	Q08188	444	547	449	449	Metal binding	Note=Calcium 3;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11980702,ECO:0000269|PubMed:12679341;Dbxref=PMID:11980702,PMID:12679341
TGM3	Q08188	444	547	467	468	Site	Note=Cleavage%3B by CTSL
TGM3	Q08188	362	444	372	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	383	385	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	386	394	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	396	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	404	407	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	408	426	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	433	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	437	440	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	362	444	444	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NUF
TGM3	Q08188	444	547	444	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NUF
TGM3	Q08188	444	547	447	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	444	547	482	489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	444	547	499	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	444	547	509	511	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	444	547	513	524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGM3	Q08188	444	547	530	543	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L9M
TGFBR1	P36897	32	114	1	33	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9661882;Dbxref=PMID:9661882
TGFBR1	P36897	32	114	34	503	Chain	ID=PRO_0000024423;Note=TGF-beta receptor type-1
TGFBR1	P36897	114	191	34	503	Chain	ID=PRO_0000024423;Note=TGF-beta receptor type-1
TGFBR1	P36897	191	268	34	503	Chain	ID=PRO_0000024423;Note=TGF-beta receptor type-1
TGFBR1	P36897	268	324	34	503	Chain	ID=PRO_0000024423;Note=TGF-beta receptor type-1
TGFBR1	P36897	32	114	34	126	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	114	191	34	126	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	114	191	127	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	114	191	148	503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	191	268	148	503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	268	324	148	503	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	114	191	175	204	Domain	Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585
TGFBR1	P36897	191	268	175	204	Domain	Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585
TGFBR1	P36897	191	268	205	495	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TGFBR1	P36897	268	324	205	495	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TGFBR1	P36897	191	268	211	219	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TGFBR1	P36897	191	268	193	194	Motif	Note=FKBP1A-binding
TGFBR1	P36897	191	268	232	232	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TGFBR1	P36897	114	191	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
TGFBR1	P36897	114	191	185	185	Modified residue	Note=Phosphothreonine%3B by TGFBR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	186	186	Modified residue	Note=Phosphothreonine%3B by TGFBR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	187	187	Modified residue	Note=Phosphoserine%3B by TGFBR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	189	189	Modified residue	Note=Phosphoserine%3B by TGFBR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	191	191	Modified residue	Note=Phosphoserine%3B by TGFBR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	191	268	191	191	Modified residue	Note=Phosphoserine%3B by TGFBR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	32	114	45	45	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TGFBR1	P36897	32	114	36	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18243111,ECO:0000269|PubMed:20207738;Dbxref=PMID:18243111,PMID:20207738
TGFBR1	P36897	32	114	38	41	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18243111,ECO:0000269|PubMed:20207738;Dbxref=PMID:18243111,PMID:20207738
TGFBR1	P36897	32	114	48	71	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18243111,ECO:0000269|PubMed:20207738;Dbxref=PMID:18243111,PMID:20207738
TGFBR1	P36897	32	114	86	100	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18243111,ECO:0000269|PubMed:20207738;Dbxref=PMID:18243111,PMID:20207738
TGFBR1	P36897	32	114	101	106	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18243111,ECO:0000269|PubMed:20207738;Dbxref=PMID:18243111,PMID:20207738
TGFBR1	P36897	32	114	114	114	Alternative sequence	ID=VSP_041326;Note=In isoform 2. T->TGPFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17845732;Dbxref=PMID:17845732
TGFBR1	P36897	114	191	114	114	Alternative sequence	ID=VSP_041326;Note=In isoform 2. T->TGPFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17845732;Dbxref=PMID:17845732
TGFBR1	P36897	114	191	115	191	Alternative sequence	ID=VSP_041327;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TGFBR1	P36897	191	268	115	191	Alternative sequence	ID=VSP_041327;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TGFBR1	P36897	32	114	41	41	Natural variant	ID=VAR_065826;Note=In MSSE%3B hypomorphic mutation. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358634;Dbxref=PMID:21358634
TGFBR1	P36897	32	114	45	45	Natural variant	ID=VAR_065827;Note=In MSSE%3B hypomorphic mutation. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358634;Dbxref=dbSNP:rs387906696,PMID:21358634
TGFBR1	P36897	32	114	52	52	Natural variant	ID=VAR_065828;Note=In MSSE%3B hypomorphic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358634;Dbxref=dbSNP:rs587776865,PMID:21358634
TGFBR1	P36897	32	114	83	83	Natural variant	ID=VAR_065829;Note=In MSSE%3B hypomorphic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21358634;Dbxref=dbSNP:rs757374917,PMID:21358634
TGFBR1	P36897	114	191	139	139	Natural variant	ID=VAR_054160;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18987736;Dbxref=dbSNP:rs148176750,PMID:18987736
TGFBR1	P36897	114	191	153	153	Natural variant	ID=VAR_041412;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56014374,PMID:17344846
TGFBR1	P36897	191	268	200	200	Natural variant	ID=VAR_022344;Note=In LDS1. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731757;Dbxref=dbSNP:rs121918712,PMID:15731757
TGFBR1	P36897	191	268	232	232	Natural variant	ID=VAR_029481;Note=In LDS1. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16928994;Dbxref=PMID:16928994
TGFBR1	P36897	191	268	241	241	Natural variant	ID=VAR_029482;Note=In LDS1. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16596670,ECO:0000269|PubMed:16791849;Dbxref=dbSNP:rs111854391,PMID:16596670,PMID:16791849
TGFBR1	P36897	191	268	266	266	Natural variant	ID=VAR_066720;Note=In LDS1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22113417;Dbxref=PMID:22113417
TGFBR1	P36897	191	268	267	267	Natural variant	ID=VAR_029483;Note=In a patient with Marfan syndrome. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16791849;Dbxref=PMID:16791849
TGFBR1	P36897	268	324	291	291	Natural variant	ID=VAR_041413;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35974499,PMID:17344846
TGFBR1	P36897	268	324	318	318	Natural variant	ID=VAR_022345;Note=In LDS1. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731757;Dbxref=dbSNP:rs121918710,PMID:15731757
TGFBR1	P36897	114	191	185	186	Mutagenesis	Note=Loss of phosphorylation on threonine residues. Loss of threonine phosphorylation%2C reduced phosphorylation on serine residues and loss of response to TGF-beta%3B when associated with A-187%3B A-189 and A-191. TT->VV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	187	187	Mutagenesis	Note=Loss of threonine phosphorylation%2C reduced phosphorylation on serine residues and loss of response to TGF-beta%3B when associated with 185-VV-186%3B A-189 and A-191. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	189	189	Mutagenesis	Note=Loss of threonine phosphorylation%2C reduced phosphorylation on serine residues and loss of response to TGF-beta%3B when associated with 185-VV-186%3B A-187 and A-191. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	114	191	191	191	Mutagenesis	Note=Loss of threonine phosphorylation%2C reduced phosphorylation on serine residues and loss of response to TGF-beta%3B when associated with 185-VV-186%3B A-187 and A-189. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	191	268	191	191	Mutagenesis	Note=Loss of threonine phosphorylation%2C reduced phosphorylation on serine residues and loss of response to TGF-beta%3B when associated with 185-VV-186%3B A-187 and A-189. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	191	268	193	193	Mutagenesis	Note=Loss of interaction with FKBP1A. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9233797;Dbxref=PMID:9233797
TGFBR1	P36897	191	268	194	194	Mutagenesis	Note=Loss of interaction with FKBP1A. P->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9233797;Dbxref=PMID:9233797
TGFBR1	P36897	191	268	200	200	Mutagenesis	Note=Loss of response to TGF-beta. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	191	268	200	200	Mutagenesis	Note=Loss of phosphorylation. Loss of response to TGF-beta. T->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	191	268	204	204	Mutagenesis	Note=Constitutive activation. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	191	268	204	204	Mutagenesis	Note=Reduced phosphorylation. Reduced response to TGF-beta. T->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774578;Dbxref=PMID:7774578
TGFBR1	P36897	32	114	35	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	42	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	51	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	61	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PJY
TGFBR1	P36897	32	114	69	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	74	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PJY
TGFBR1	P36897	32	114	84	86	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	89	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PJY
TGFBR1	P36897	32	114	94	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PJY
TGFBR1	P36897	32	114	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KFD
TGFBR1	P36897	32	114	107	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L5S
TGFBR1	P36897	114	191	177	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B6C
TGFBR1	P36897	114	191	187	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KCF
TGFBR1	P36897	114	191	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B6C
TGFBR1	P36897	191	268	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B6C
TGFBR1	P36897	191	268	202	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	191	268	205	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	191	268	215	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	191	268	227	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	191	268	236	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	191	268	239	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	191	268	251	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KCF
TGFBR1	P36897	191	268	262	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	268	324	262	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	268	324	271	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	268	324	288	294	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	268	324	299	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8S
TGFBR1	P36897	268	324	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E8X
ACAA1	P09110	272	332	27	424	Chain	ID=PRO_0000034067;Note=3-ketoacyl-CoA thiolase%2C peroxisomal
ACAA1	P09110	182	208	27	424	Chain	ID=PRO_0000034067;Note=3-ketoacyl-CoA thiolase%2C peroxisomal
ACAA1	P09110	149	181	27	424	Chain	ID=PRO_0000034067;Note=3-ketoacyl-CoA thiolase%2C peroxisomal
ACAA1	P09110	149	181	149	181	Alternative sequence	ID=VSP_046195;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAA1	P09110	272	332	272	331	Alternative sequence	ID=VSP_046196;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAA1	P09110	149	181	172	172	Natural variant	ID=VAR_011904;Note=E->D;Dbxref=dbSNP:rs156265
ACAA1	P09110	149	181	143	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	149	181	153	155	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	149	181	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	149	181	172	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	149	181	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	182	208	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	149	181	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	182	208	196	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	272	332	279	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	272	332	290	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	272	332	302	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	272	332	314	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
ACAA1	P09110	272	332	320	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IIK
THOC5	Q13769	80	118	2	683	Chain	ID=PRO_0000079577;Note=THO complex subunit 5 homolog
THOC5	Q13769	80	118	2	683	Chain	ID=PRO_0000079577;Note=THO complex subunit 5 homolog
THOC5	Q13769	80	118	2	683	Chain	ID=PRO_0000079577;Note=THO complex subunit 5 homolog
THOC5	Q13769	80	118	2	683	Chain	ID=PRO_0000079577;Note=THO complex subunit 5 homolog
THOC5	Q13769	80	118	2	199	Region	Note=Interaction with THOC7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19059247;Dbxref=PMID:19059247
THOC5	Q13769	80	118	2	199	Region	Note=Interaction with THOC7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19059247;Dbxref=PMID:19059247
THOC5	Q13769	80	118	2	199	Region	Note=Interaction with THOC7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19059247;Dbxref=PMID:19059247
THOC5	Q13769	80	118	2	199	Region	Note=Interaction with THOC7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19059247;Dbxref=PMID:19059247
THOC5	Q13769	80	118	2	144	Region	Note=Interaction with CSF1R;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BKT7
THOC5	Q13769	80	118	2	144	Region	Note=Interaction with CSF1R;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BKT7
THOC5	Q13769	80	118	2	144	Region	Note=Interaction with CSF1R;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BKT7
THOC5	Q13769	80	118	2	144	Region	Note=Interaction with CSF1R;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BKT7
TEK	Q02763	17	121	1	22	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
TEK	Q02763	17	121	23	1124	Chain	ID=PRO_0000024474;Note=Angiopoietin-1 receptor
TEK	Q02763	121	158	23	1124	Chain	ID=PRO_0000024474;Note=Angiopoietin-1 receptor
TEK	Q02763	300	343	23	1124	Chain	ID=PRO_0000024474;Note=Angiopoietin-1 receptor
TEK	Q02763	442	496	23	1124	Chain	ID=PRO_0000024474;Note=Angiopoietin-1 receptor
TEK	Q02763	17	121	23	748	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEK	Q02763	121	158	23	748	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEK	Q02763	300	343	23	748	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEK	Q02763	442	496	23	748	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEK	Q02763	17	121	44	123	Domain	Note=Ig-like C2-type 1
TEK	Q02763	121	158	44	123	Domain	Note=Ig-like C2-type 1
TEK	Q02763	300	343	301	341	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TEK	Q02763	442	496	447	541	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TEK	Q02763	121	158	140	140	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
TEK	Q02763	121	158	158	158	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEK	Q02763	442	496	464	464	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TEK	Q02763	17	121	44	102	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
TEK	Q02763	300	343	302	311	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
TEK	Q02763	300	343	315	323	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
TEK	Q02763	300	343	317	329	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
TEK	Q02763	300	343	331	340	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
TEK	Q02763	17	121	18	121	Alternative sequence	ID=VSP_042137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TEK	Q02763	121	158	18	121	Alternative sequence	ID=VSP_042137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TEK	Q02763	300	343	300	342	Alternative sequence	ID=VSP_042138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TEK	Q02763	17	121	19	210	Natural variant	ID=VAR_078045;Note=In GLC3E%3B formation of protein aggregates. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27270174;Dbxref=PMID:27270174
TEK	Q02763	121	158	19	210	Natural variant	ID=VAR_078045;Note=In GLC3E%3B formation of protein aggregates. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27270174;Dbxref=PMID:27270174
TEK	Q02763	17	121	117	117	Natural variant	ID=VAR_035714;Note=In breast cancer samples%3B infiltrating ductal carcinoma%3B somatic mutation. K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:17344846;Dbxref=PMID:16959974,PMID:17344846
TEK	Q02763	121	158	148	148	Natural variant	ID=VAR_041855;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35969327,PMID:17344846
TEK	Q02763	442	496	486	486	Natural variant	ID=VAR_024578;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1334811,PMID:17344846
TEK	Q02763	17	121	26	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	33	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	40	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	56	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	61	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	64	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	80	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	98	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	17	121	109	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	121	158	123	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	121	158	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	121	158	139	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	121	158	153	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	300	343	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	300	343	325	327	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	300	343	328	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
TEK	Q02763	442	496	446	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
TEK	Q02763	442	496	452	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
TEK	Q02763	442	496	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
TEK	Q02763	442	496	469	472	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
TEK	Q02763	442	496	476	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
TEK	Q02763	442	496	493	504	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
THSD4	Q6ZMP0	805	863	26	1018	Chain	ID=PRO_0000313583;Note=Thrombospondin type-1 domain-containing protein 4
THSD4	Q6ZMP0	805	863	793	851	Domain	Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD4	Q6ZMP0	805	863	852	911	Domain	Note=TSP type-1 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD4	Q6ZMP0	805	863	524	1018	Alternative sequence	ID=VSP_030040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
THSD4	Q6ZMP0	805	863	580	1018	Alternative sequence	ID=VSP_030041;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
THSD4	Q6ZMP0	805	863	806	806	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TIGIT	Q495A1	20	130	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	22	244	Chain	ID=PRO_0000299405;Note=T-cell immunoreceptor with Ig and ITIM domains
TIGIT	Q495A1	20	130	22	244	Chain	ID=PRO_0000299405;Note=T-cell immunoreceptor with Ig and ITIM domains
TIGIT	Q495A1	20	130	22	141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	22	141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	22	124	Domain	Note=Ig-like V-type
TIGIT	Q495A1	20	130	22	124	Domain	Note=Ig-like V-type
TIGIT	Q495A1	20	130	32	42	Region	Note=Homodimerization
TIGIT	Q495A1	20	130	32	42	Region	Note=Homodimerization
TIGIT	Q495A1	20	130	32	32	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	32	32	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	101	101	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	101	101	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIGIT	Q495A1	20	130	45	108	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:22421438;Dbxref=PMID:22421438
TIGIT	Q495A1	20	130	45	108	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:22421438;Dbxref=PMID:22421438
TIGIT	Q495A1	20	130	33	33	Natural variant	ID=VAR_056079;Note=I->V;Dbxref=dbSNP:rs13098836
TIGIT	Q495A1	20	130	33	33	Natural variant	ID=VAR_056079;Note=I->V;Dbxref=dbSNP:rs13098836
TIGIT	Q495A1	20	130	42	42	Mutagenesis	Note=Abrogates interaction with PVR%2C cell clustering and PVR signaling. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22421438;Dbxref=PMID:22421438
TIGIT	Q495A1	20	130	42	42	Mutagenesis	Note=Abrogates interaction with PVR%2C cell clustering and PVR signaling. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22421438;Dbxref=PMID:22421438
TIGIT	Q495A1	20	130	42	42	Mutagenesis	Note=Abrogates interaction with PVR%2C cell clustering and PVR signaling. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22421438;Dbxref=PMID:22421438
TIGIT	Q495A1	20	130	42	42	Mutagenesis	Note=Abrogates interaction with PVR%2C cell clustering and PVR signaling. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22421438;Dbxref=PMID:22421438
TIGIT	Q495A1	20	130	103	103	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TIGIT	Q495A1	20	130	103	103	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TIGIT	Q495A1	20	130	117	117	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TIGIT	Q495A1	20	130	117	117	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TIGIT	Q495A1	20	130	26	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	26	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	33	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	33	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	45	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	45	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	53	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	53	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	64	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	64	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	71	73	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	71	73	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	82	84	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	82	84	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	93	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	93	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	104	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	104	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	118	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIGIT	Q495A1	20	130	118	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3Q0H
TIAM2	Q8IVF5	902	933	2	1701	Chain	ID=PRO_0000317467;Note=T-lymphoma invasion and metastasis-inducing protein 2
TIAM2	Q8IVF5	902	933	890	976	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
TIAM2	Q8IVF5	902	933	1	1075	Alternative sequence	ID=VSP_030971;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10512681,ECO:0000303|PubMed:15489334;Dbxref=PMID:10512681,PMID:15489334
TIAM2	Q8IVF5	902	933	913	913	Natural variant	ID=VAR_051995;Note=R->H;Dbxref=dbSNP:rs7770537
TIPRL	O75663	128	172	1	272	Chain	ID=PRO_0000301853;Note=TIP41-like protein
TIPRL	O75663	172	204	1	272	Chain	ID=PRO_0000301853;Note=TIP41-like protein
TIPRL	O75663	172	204	173	272	Region	Note=Interaction with PPP2CA
TIPRL	O75663	172	204	173	178	Alternative sequence	ID=VSP_027883;Note=In isoform 2. RVMPSS->PGGGHL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TIPRL	O75663	172	204	179	272	Alternative sequence	ID=VSP_027884;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TIPRL	O75663	128	172	136	136	Mutagenesis	Note=Abolishes interaction with PPP2CA%2C PPP2CB and PPP4C. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17944932;Dbxref=PMID:17944932
TIPRL	O75663	172	204	196	196	Mutagenesis	Note=Abolishes interaction with PPP2CA%2C PPP2CB and PPP4C. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17944932;Dbxref=PMID:17944932
TIPRL	O75663	172	204	198	198	Mutagenesis	Note=Abolishes interaction with PPP2CA%2C PPP2CB and PPP4C. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17944932;Dbxref=PMID:17944932
TIPRL	O75663	128	172	128	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	128	172	138	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	128	172	148	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	128	172	160	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	128	172	164	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	172	204	164	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	172	204	178	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	172	204	190	192	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TIPRL	O75663	172	204	193	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9G
TLN1	Q9Y490	2220	2256	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1911	1960	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1871	1911	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1787	1837	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1730	1787	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1490	1544	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1371	1401	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	995	1040	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	957	995	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	632	665	1	2541	Chain	ID=PRO_0000219428;Note=Talin-1
TLN1	Q9Y490	1911	1960	1327	1948	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854
TLN1	Q9Y490	1871	1911	1327	1948	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854
TLN1	Q9Y490	1787	1837	1327	1948	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854
TLN1	Q9Y490	1730	1787	1327	1948	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854
TLN1	Q9Y490	1490	1544	1327	1948	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854
TLN1	Q9Y490	1371	1401	1327	1948	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854
TLN1	Q9Y490	1490	1544	1359	1659	Region	Note=Interaction with VCL and F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26039
TLN1	Q9Y490	1371	1401	1359	1659	Region	Note=Interaction with VCL and F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26039
TLN1	Q9Y490	995	1040	1021	1021	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TLN1	Q9Y490	1490	1544	1544	1544	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26039
TLN1	Q9Y490	1871	1911	1878	1878	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26039
TLN1	Q9Y490	1911	1960	1919	1919	Natural variant	ID=VAR_023752;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854239,PMID:15489334
TLN1	Q9Y490	2220	2256	2256	2256	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLN2	Q9Y4G6	371	405	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	959	997	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	997	1042	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	1698	1732	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	1732	1789	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	1789	1838	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	1872	1912	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	2221	2257	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	2397	2458	1	2542	Chain	ID=PRO_0000219431;Note=Talin-2
TLN2	Q9Y4G6	371	405	88	406	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
TLN2	Q9Y4G6	2397	2458	2294	2533	Domain	Note=I/LWEQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00292
TLN2	Q9Y4G6	371	405	312	406	Region	Note=Interaction with PIP5K1C;Ontology_term=ECO:0000250;evidence=ECO:0000250
TLN2	Q9Y4G6	959	997	861	1193	Compositional bias	Note=Ala-rich
TLN2	Q9Y4G6	997	1042	861	1193	Compositional bias	Note=Ala-rich
TLN2	Q9Y4G6	997	1042	1023	1023	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TLN2	Q9Y4G6	1872	1912	1877	1877	Natural variant	ID=VAR_055314;Note=V->I;Dbxref=dbSNP:rs7182971
TMEM253	P0C7T8	36	73	1	217	Chain	ID=PRO_0000343722;Note=Transmembrane protein 253
TMEM253	P0C7T8	92	129	1	217	Chain	ID=PRO_0000343722;Note=Transmembrane protein 253
TMEM253	P0C7T8	129	178	1	217	Chain	ID=PRO_0000343722;Note=Transmembrane protein 253
TMEM253	P0C7T8	36	73	1	217	Chain	ID=PRO_0000343722;Note=Transmembrane protein 253
TMEM253	P0C7T8	92	129	1	217	Chain	ID=PRO_0000343722;Note=Transmembrane protein 253
TMEM253	P0C7T8	129	178	1	217	Chain	ID=PRO_0000343722;Note=Transmembrane protein 253
TMEM253	P0C7T8	36	73	33	53	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	36	73	33	53	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	36	73	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	36	73	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	92	129	96	116	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	92	129	96	116	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	129	178	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM253	P0C7T8	129	178	138	158	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM2D3	Q9BRN9	30	56	30	247	Chain	ID=PRO_0000298989;Note=TM2 domain-containing protein 3
TM2D3	Q9BRN9	30	56	31	56	Alternative sequence	ID=VSP_027496;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11278849,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11278849,PMID:14702039,PMID:15489334
TMEM175	Q9BSA9	51	64	1	504	Chain	ID=PRO_0000282588;Note=Endosomal/lysosomal potassium channel TMEM175
TMEM175	Q9BSA9	114	126	1	504	Chain	ID=PRO_0000282588;Note=Endosomal/lysosomal potassium channel TMEM175
TMEM175	Q9BSA9	126	154	1	504	Chain	ID=PRO_0000282588;Note=Endosomal/lysosomal potassium channel TMEM175
TMEM175	Q9BSA9	51	64	36	56	Transmembrane	Note=Helical%3B Name%3DTM1-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM175	Q9BSA9	51	64	57	72	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM175	Q9BSA9	114	126	111	131	Transmembrane	Note=Helical%3B Name%3DTM3-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM175	Q9BSA9	126	154	111	131	Transmembrane	Note=Helical%3B Name%3DTM3-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM175	Q9BSA9	126	154	132	137	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM175	Q9BSA9	126	154	138	158	Transmembrane	Note=Helical%3B Name%3DTM4-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM175	Q9BSA9	51	64	58	63	Region	Note=Short helix H1-1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:K9UJK2
TMEM175	Q9BSA9	51	64	53	53	Site	Note=Hydrophobic filter residue 3-1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:K9UJK2
TMEM175	Q9BSA9	51	64	1	116	Alternative sequence	ID=VSP_024213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TMEM175	Q9BSA9	114	126	1	116	Alternative sequence	ID=VSP_024213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TMEM175	Q9BSA9	51	64	53	53	Mutagenesis	Note=Does not affect selectivity%3B when associated with A-278. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28723891;Dbxref=PMID:28723891
TMEM50A	O95807	91	122	2	157	Chain	ID=PRO_0000174181;Note=Transmembrane protein 50A
TMEM50A	O95807	91	122	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TOLLIP	Q9H0E2	122	173	2	274	Chain	ID=PRO_0000072625;Note=Toll-interacting protein
TOLLIP	Q9H0E2	61	122	2	274	Chain	ID=PRO_0000072625;Note=Toll-interacting protein
TOLLIP	Q9H0E2	122	173	40	135	Domain	Note=C2
TOLLIP	Q9H0E2	61	122	40	135	Domain	Note=C2
TOLLIP	Q9H0E2	122	173	133	136	Motif	Note=AIM1
TOLLIP	Q9H0E2	122	173	151	154	Motif	Note=AIM2
TOLLIP	Q9H0E2	61	122	1	69	Alternative sequence	ID=VSP_056301;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOLLIP	Q9H0E2	122	173	161	161	Natural variant	ID=VAR_079499;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26282398;Dbxref=dbSNP:rs1037270334,PMID:26282398
TOLLIP	Q9H0E2	122	173	150	150	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TOPBP1	Q92547	1421	1475	1	1522	Chain	ID=PRO_0000072631;Note=DNA topoisomerase 2-binding protein 1
TOPBP1	Q92547	247	307	1	1522	Chain	ID=PRO_0000072631;Note=DNA topoisomerase 2-binding protein 1
TOPBP1	Q92547	247	307	195	284	Domain	Note=BRCT 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033
TOPBP1	Q92547	1421	1475	1389	1486	Domain	Note=BRCT 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033
TOPBP1	Q92547	247	307	298	298	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TOPBP1	Q92547	247	307	301	301	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
TOPBP1	Q92547	247	307	249	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OLC
TOPBP1	Q92547	247	307	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OLC
TOPBP1	Q92547	247	307	264	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OLC
TOPBP1	Q92547	247	307	279	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OLC
TOPBP1	Q92547	247	307	282	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OLC
TOPBP1	Q92547	1421	1475	1428	1433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL2
TOPBP1	Q92547	1421	1475	1435	1439	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL2
TOPBP1	Q92547	1421	1475	1453	1458	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL2
TOPBP1	Q92547	1421	1475	1462	1465	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL2
TOPBP1	Q92547	1421	1475	1467	1474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL2
TPRKB	Q9Y3C4	88	147	1	175	Chain	ID=PRO_0000279220;Note=EKC/KEOPS complex subunit TPRKB
TPRKB	Q9Y3C4	47	88	1	175	Chain	ID=PRO_0000279220;Note=EKC/KEOPS complex subunit TPRKB
TPRKB	Q9Y3C4	47	88	15	47	Alternative sequence	ID=VSP_023414;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12659830;Dbxref=PMID:12659830
TPRKB	Q9Y3C4	47	88	47	47	Alternative sequence	ID=VSP_023415;Note=In isoform 3. V->VFHSCCPGWSAMARSWLTATSASRVQAIVLPQPPELLGLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12659830;Dbxref=PMID:12659830
TPRKB	Q9Y3C4	88	147	136	136	Natural variant	ID=VAR_080355;Note=In GAMOS5. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28805828;Dbxref=PMID:28805828
TPRKB	Q9Y3C4	88	147	147	147	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TPRKB	Q9Y3C4	47	88	45	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	47	88	51	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	47	88	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	47	88	71	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	47	88	75	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	47	88	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	88	147	89	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	88	147	103	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	88	147	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	88	147	126	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	88	147	133	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
TPRKB	Q9Y3C4	88	147	142	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ENP
SLIT3	O75094	1059	1104	34	1523	Chain	ID=PRO_0000007732;Note=Slit homolog 3 protein
SLIT3	O75094	312	335	34	1523	Chain	ID=PRO_0000007732;Note=Slit homolog 3 protein
SLIT3	O75094	186	209	34	1523	Chain	ID=PRO_0000007732;Note=Slit homolog 3 protein
SLIT3	O75094	138	161	34	1523	Chain	ID=PRO_0000007732;Note=Slit homolog 3 protein
SLIT3	O75094	90	113	34	1523	Chain	ID=PRO_0000007732;Note=Slit homolog 3 protein
SLIT3	O75094	90	113	86	107	Repeat	Note=LRR 2
SLIT3	O75094	90	113	110	131	Repeat	Note=LRR 3
SLIT3	O75094	138	161	134	155	Repeat	Note=LRR 4
SLIT3	O75094	138	161	158	179	Repeat	Note=LRR 5
SLIT3	O75094	186	209	182	203	Repeat	Note=LRR 6
SLIT3	O75094	312	335	308	329	Repeat	Note=LRR 7
SLIT3	O75094	312	335	332	353	Repeat	Note=LRR 8
SLIT3	O75094	1059	1104	1034	1072	Domain	Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SLIT3	O75094	1059	1104	1074	1110	Domain	Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
SLIT3	O75094	186	209	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLIT3	O75094	1059	1104	1045	1060	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLIT3	O75094	1059	1104	1062	1071	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLIT3	O75094	1059	1104	1078	1089	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLIT3	O75094	1059	1104	1083	1098	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLIT3	O75094	1059	1104	1100	1109	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SLIT3	O75094	1059	1104	1064	1064	Natural variant	ID=VAR_049006;Note=P->A;Dbxref=dbSNP:rs10072243
SLCO2B1	O94956	27	73	1	709	Chain	ID=PRO_0000191061;Note=Solute carrier organic anion transporter family member 2B1
SLCO2B1	O94956	205	238	1	709	Chain	ID=PRO_0000191061;Note=Solute carrier organic anion transporter family member 2B1
SLCO2B1	O94956	27	73	1	49	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2B1	O94956	27	73	50	69	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2B1	O94956	27	73	70	88	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2B1	O94956	205	238	186	215	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2B1	O94956	205	238	216	234	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2B1	O94956	205	238	235	255	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2B1	O94956	27	73	34	34	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BXB6
SLCO2B1	O94956	27	73	1	116	Alternative sequence	ID=VSP_006147;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLCO2B1	O94956	27	73	6	149	Alternative sequence	ID=VSP_054110;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLCO2B1	O94956	205	238	150	260	Alternative sequence	ID=VSP_006148;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SLCO2B1	O94956	205	238	215	215	Sequence conflict	Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
GH1	P01241	57	97	27	217	Chain	ID=PRO_0000032988;Note=Somatotropin
GH1	P01241	57	97	79	191	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:5144027;Dbxref=PMID:5144027
GH1	P01241	57	97	58	97	Alternative sequence	ID=VSP_045642;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GH1	P01241	57	97	58	72	Alternative sequence	ID=VSP_006200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GH1	P01241	57	97	67	67	Natural variant	ID=VAR_015805;Note=In IGHD1B%3B reduced ability to activate the JAK/STAT pathway. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655557;Dbxref=PMID:12655557
GH1	P01241	57	97	73	73	Natural variant	ID=VAR_015806;Note=In IGHD1B%3B reduced ability to activate the JAK/STAT pathway. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655557;Dbxref=dbSNP:rs71640276,PMID:12655557
GH1	P01241	57	97	79	79	Natural variant	ID=VAR_032702;Note=In short stature%3B idiopathic autosomal%3B affects binding affinity of GH for GHR and the potency of GH to activate the JAK2/STAT5 signaling pathway. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713716;Dbxref=dbSNP:rs137853222,PMID:15713716
GH1	P01241	57	97	97	97	Natural variant	ID=VAR_015807;Note=In IGHD1B%3B reduced ability to activate the JAK/STAT pathway. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12655557;Dbxref=PMID:12655557
GH1	P01241	57	97	32	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HUW
GH1	P01241	57	97	64	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HUW
GH1	P01241	57	97	73	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HGU
GH1	P01241	57	97	80	83	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HUW
GH1	P01241	57	97	90	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HUW
SAP130	Q9H0E3	798	881	1	1048	Chain	ID=PRO_0000283736;Note=Histone deacetylase complex subunit SAP130
SAP130	Q9H0E3	518	619	1	1048	Chain	ID=PRO_0000283736;Note=Histone deacetylase complex subunit SAP130
SAP130	Q9H0E3	395	430	1	1048	Chain	ID=PRO_0000283736;Note=Histone deacetylase complex subunit SAP130
SAP130	Q9H0E3	798	881	836	1047	Region	Note=Interactions with SIN3A and HDAC1
SAP130	Q9H0E3	798	881	709	836	Compositional bias	Note=Pro-rich
SAP130	Q9H0E3	798	881	855	855	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SAP130	Q9H0E3	798	881	856	856	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
SAP130	Q9H0E3	798	881	875	875	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SAP130	Q9H0E3	798	881	864	864	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SAP130	Q9H0E3	798	881	869	869	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
SAP130	Q9H0E3	395	430	1	470	Alternative sequence	ID=VSP_024355;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SP140L	Q9H930	286	321	1	580	Chain	ID=PRO_0000321936;Note=Nuclear body protein SP140-like protein
SP140L	Q9H930	286	321	293	374	Domain	Note=SAND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00185
SP140L	Q9H930	286	321	292	292	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SP140L	Q9H930	286	321	217	580	Alternative sequence	ID=VSP_031832;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SP140L	Q9H930	286	321	287	321	Alternative sequence	ID=VSP_031833;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPAG5	Q96R06	580	620	1	1193	Chain	ID=PRO_0000072093;Note=Sperm-associated antigen 5
SPAG5	Q96R06	580	620	482	850	Region	Note=Interaction with KNSTRN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21402792;Dbxref=PMID:21402792
SPAG5	Q96R06	580	620	545	608	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPAG5	Q96R06	580	620	617	789	Compositional bias	Note=Gln-rich
AGMAT	Q9BSE5	240	300	36	352	Chain	ID=PRO_0000002089;Note=Agmatinase%2C mitochondrial
AGMAT	Q9BSE5	240	300	276	276	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00742
AGMAT	Q9BSE5	240	300	276	276	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00742
AGMAT	Q9BSE5	240	300	278	278	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00742
SRF	P11831	347	387	1	508	Chain	ID=PRO_0000199423;Note=Serum response factor
SRF	P11831	387	451	1	508	Chain	ID=PRO_0000199423;Note=Serum response factor
SRF	P11831	387	451	435	435	Modified residue	Note=Phosphoserine%3B by dsDNA kinase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8407951;Dbxref=PMID:8407951
SRF	P11831	387	451	446	446	Modified residue	Note=Phosphoserine%3B by dsDNA kinase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8407951;Dbxref=PMID:8407951
SRF	P11831	347	387	383	383	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:1512232;Dbxref=PMID:1512232
SRC	P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
SRC	P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
SRC	P12931	234	286	2	536	Chain	ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src
SRC	P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
SRC	P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
SRC	P12931	234	286	151	248	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
SRC	P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SRC	P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SRC	P12931	234	286	270	523	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SRC	P12931	234	286	276	284	Nucleotide binding	Note=ATP
SRC	P12931	234	286	276	284	Nucleotide binding	Note=ATP
SRC	P12931	234	286	276	284	Nucleotide binding	Note=ATP
SRC	P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
SRC	P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
SRC	P12931	234	286	237	237	Natural variant	ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846
SRC	P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	270	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
SRC	P12931	234	286	283	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FMK
TMPRSS2	O15393	108	148	1	255	Chain	ID=PRO_0000027855;Note=Transmembrane protease serine 2 non-catalytic chain
TMPRSS2	O15393	108	148	1	255	Chain	ID=PRO_0000027855;Note=Transmembrane protease serine 2 non-catalytic chain
TMPRSS2	O15393	438	489	256	492	Chain	ID=PRO_0000027856;Note=Transmembrane protease serine 2 catalytic chain
TMPRSS2	O15393	358	390	256	492	Chain	ID=PRO_0000027856;Note=Transmembrane protease serine 2 catalytic chain
TMPRSS2	O15393	438	489	256	492	Chain	ID=PRO_0000027856;Note=Transmembrane protease serine 2 catalytic chain
TMPRSS2	O15393	358	390	256	492	Chain	ID=PRO_0000027856;Note=Transmembrane protease serine 2 catalytic chain
TMPRSS2	O15393	438	489	106	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS2	O15393	358	390	106	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS2	O15393	108	148	106	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS2	O15393	438	489	106	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS2	O15393	358	390	106	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS2	O15393	108	148	106	492	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS2	O15393	108	148	112	149	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
TMPRSS2	O15393	108	148	112	149	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
TMPRSS2	O15393	438	489	256	489	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS2	O15393	358	390	256	489	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS2	O15393	438	489	256	489	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS2	O15393	358	390	256	489	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS2	O15393	438	489	441	441	Active site	Note=Charge relay system
TMPRSS2	O15393	438	489	441	441	Active site	Note=Charge relay system
TMPRSS2	O15393	108	148	113	126	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	108	148	113	126	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	108	148	120	139	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	108	148	120	139	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	108	148	133	148	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	108	148	133	148	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	358	390	244	365	Disulfide bond	Note=Interchain (between non-catalytic and catalytic chains);Ontology_term=ECO:0000255,ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS2	O15393	358	390	244	365	Disulfide bond	Note=Interchain (between non-catalytic and catalytic chains);Ontology_term=ECO:0000255,ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS2	O15393	438	489	437	465	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	438	489	437	465	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS2	O15393	438	489	449	449	Natural variant	ID=VAR_011692;Note=K->N;Dbxref=dbSNP:rs1056602
TMPRSS2	O15393	438	489	449	449	Natural variant	ID=VAR_011692;Note=K->N;Dbxref=dbSNP:rs1056602
TMPRSS2	O15393	438	489	441	441	Mutagenesis	Note=Loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11245484;Dbxref=PMID:11245484
TMPRSS2	O15393	438	489	441	441	Mutagenesis	Note=Loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11245484;Dbxref=PMID:11245484
TMPRSS2	O15393	438	489	489	491	Sequence conflict	Note=RAD->KAN;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMPRSS2	O15393	438	489	489	491	Sequence conflict	Note=RAD->KAN;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRSF5	Q13243	66	98	1	272	Chain	ID=PRO_0000081927;Note=Serine/arginine-rich splicing factor 5
SRSF5	Q13243	147	183	1	272	Chain	ID=PRO_0000081927;Note=Serine/arginine-rich splicing factor 5
SRSF5	Q13243	66	98	1	272	Chain	ID=PRO_0000081927;Note=Serine/arginine-rich splicing factor 5
SRSF5	Q13243	147	183	1	272	Chain	ID=PRO_0000081927;Note=Serine/arginine-rich splicing factor 5
SRSF5	Q13243	66	98	1	272	Chain	ID=PRO_0000081927;Note=Serine/arginine-rich splicing factor 5
SRSF5	Q13243	147	183	1	272	Chain	ID=PRO_0000081927;Note=Serine/arginine-rich splicing factor 5
SRSF5	Q13243	66	98	4	74	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF5	Q13243	66	98	4	74	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF5	Q13243	66	98	4	74	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF5	Q13243	147	183	108	181	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF5	Q13243	147	183	108	181	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF5	Q13243	147	183	108	181	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF5	Q13243	66	98	78	83	Compositional bias	Note=Gly-rich (hinge region)
SRSF5	Q13243	66	98	78	83	Compositional bias	Note=Gly-rich (hinge region)
SRSF5	Q13243	66	98	78	83	Compositional bias	Note=Gly-rich (hinge region)
SRSF5	Q13243	147	183	182	267	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF5	Q13243	147	183	182	267	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF5	Q13243	147	183	182	267	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF5	Q13243	66	98	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRSF5	Q13243	66	98	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRSF5	Q13243	66	98	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRSF5	Q13243	147	183	167	167	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SRSF5	Q13243	147	183	167	167	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SRSF5	Q13243	147	183	167	167	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SRSF5	Q13243	147	183	108	272	Alternative sequence	ID=VSP_005865;Note=In isoform SRP40-2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:7556075,ECO:0000303|Ref.4;Dbxref=PMID:14702039,PMID:17974005,PMID:19054851,PMID:7556075
SRSF5	Q13243	147	183	108	272	Alternative sequence	ID=VSP_005865;Note=In isoform SRP40-2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:7556075,ECO:0000303|Ref.4;Dbxref=PMID:14702039,PMID:17974005,PMID:19054851,PMID:7556075
SRSF5	Q13243	147	183	108	272	Alternative sequence	ID=VSP_005865;Note=In isoform SRP40-2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:7556075,ECO:0000303|Ref.4;Dbxref=PMID:14702039,PMID:17974005,PMID:19054851,PMID:7556075
SRSF5	Q13243	147	183	160	160	Natural variant	ID=VAR_014713;Note=A->S;Dbxref=dbSNP:rs1057683
SRSF5	Q13243	147	183	160	160	Natural variant	ID=VAR_014713;Note=A->S;Dbxref=dbSNP:rs1057683
SRSF5	Q13243	147	183	160	160	Natural variant	ID=VAR_014713;Note=A->S;Dbxref=dbSNP:rs1057683
TMPRSS5	Q9H3S3	402	453	1	457	Chain	ID=PRO_0000088694;Note=Transmembrane protease serine 5
TMPRSS5	Q9H3S3	402	453	71	457	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS5	Q9H3S3	402	453	218	453	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS5	Q9H3S3	402	453	405	405	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS5	Q9H3S3	402	453	342	411	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS5	Q9H3S3	402	453	401	429	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
TMPRSS5	Q9H3S3	402	453	428	428	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMPRSS7	Q7RTY8	230	243	1	843	Chain	ID=PRO_0000027859;Note=Transmembrane protease serine 7
TMPRSS7	Q7RTY8	230	243	98	843	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS7	Q7RTY8	230	243	106	234	Domain	Note=SEA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
TMPRSS7	Q7RTY8	230	243	1	271	Alternative sequence	ID=VSP_040771;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMPRSS7	Q7RTY8	230	243	231	243	Alternative sequence	ID=VSP_040774;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMTC1	Q8IUR5	403	450	1	882	Chain	ID=PRO_0000280288;Note=Transmembrane and TPR repeat-containing protein 1
TMTC1	Q8IUR5	365	402	1	882	Chain	ID=PRO_0000280288;Note=Transmembrane and TPR repeat-containing protein 1
TMTC1	Q8IUR5	309	364	1	882	Chain	ID=PRO_0000280288;Note=Transmembrane and TPR repeat-containing protein 1
TMTC1	Q8IUR5	136	204	1	882	Chain	ID=PRO_0000280288;Note=Transmembrane and TPR repeat-containing protein 1
TMTC1	Q8IUR5	136	204	161	181	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	136	204	198	218	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	309	364	314	334	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	365	402	355	375	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	309	364	355	375	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	365	402	382	402	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	403	450	404	424	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	403	450	439	459	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	136	204	184	184	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMTC1	Q8IUR5	403	450	1	652	Alternative sequence	ID=VSP_023611;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMTC1	Q8IUR5	365	402	1	652	Alternative sequence	ID=VSP_023611;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMTC1	Q8IUR5	309	364	1	652	Alternative sequence	ID=VSP_023611;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMTC1	Q8IUR5	136	204	1	652	Alternative sequence	ID=VSP_023611;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMTC1	Q8IUR5	136	204	1	237	Alternative sequence	ID=VSP_023612;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMTC1	Q8IUR5	309	364	238	312	Alternative sequence	ID=VSP_023613;Note=In isoform 2. SNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMM->MTKQDSASKKKKKRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMTC1	Q8IUR5	309	364	312	312	Alternative sequence	ID=VSP_023614;Note=In isoform 3. M->MRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMX4	Q9H1E5	171	205	24	349	Chain	ID=PRO_0000034191;Note=Thioredoxin-related transmembrane protein 4
TMX4	Q9H1E5	113	155	24	349	Chain	ID=PRO_0000034191;Note=Thioredoxin-related transmembrane protein 4
TMX4	Q9H1E5	171	205	190	210	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMX4	Q9H1E5	113	155	30	137	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TNFSF13B	Q9Y275	141	160	1	285	Chain	ID=PRO_0000034528;Note=Tumor necrosis factor ligand superfamily member 13b%2C membrane form
TNFSF13B	Q9Y275	141	160	134	285	Chain	ID=PRO_0000034529;Note=Tumor necrosis factor ligand superfamily member 13b%2C soluble form
TNFSF13B	Q9Y275	141	160	68	285	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFSF13B	Q9Y275	141	160	142	160	Alternative sequence	ID=VSP_041183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12867412;Dbxref=PMID:12867412
TNFSF13B	Q9Y275	141	160	146	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KXG
TNFSF13B	Q9Y275	141	160	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KXG
ALDH5A1	P51649	242	290	48	535	Chain	ID=PRO_0000007184;Note=Succinate-semialdehyde dehydrogenase%2C mitochondrial
ALDH5A1	P51649	290	338	48	535	Chain	ID=PRO_0000007184;Note=Succinate-semialdehyde dehydrogenase%2C mitochondrial
ALDH5A1	P51649	242	290	284	289	Nucleotide binding	Note=NAD
ALDH5A1	P51649	290	338	306	306	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10007,ECO:0000255|PROSITE-ProRule:PRU10008
ALDH5A1	P51649	290	338	334	334	Binding site	Note=Substrate
ALDH5A1	P51649	242	290	265	265	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWF0
ALDH5A1	P51649	242	290	265	265	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWF0
ALDH5A1	P51649	242	290	242	242	Alternative sequence	ID=VSP_045231;Note=In isoform 2. E->EVNQGFLLDLDPLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12208142;Dbxref=PMID:12208142
ALDH5A1	P51649	242	290	255	255	Natural variant	ID=VAR_026203;Note=In SSADHD%3B 17%25 of activity. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14635103;Dbxref=dbSNP:rs145087265,PMID:14635103
ALDH5A1	P51649	242	290	268	268	Natural variant	ID=VAR_026204;Note=In SSADHD%3B <1%25 of activity. G->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11243727,ECO:0000269|PubMed:14635103;Dbxref=dbSNP:rs375628463,PMID:11243727,PMID:14635103
ALDH5A1	P51649	290	338	335	335	Natural variant	ID=VAR_026205;Note=In SSADHD%3B 1%25 of activity. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14635103;Dbxref=dbSNP:rs72552283,PMID:14635103
ALDH5A1	P51649	290	338	334	334	Mutagenesis	Note=Reduces catalytic activity to less than 15%25 of wild-type. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19300440;Dbxref=PMID:19300440
ALDH5A1	P51649	242	290	235	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	242	290	253	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	242	290	261	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	242	290	277	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	242	290	286	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	290	338	286	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	290	338	298	300	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	290	338	302	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	290	338	309	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	290	338	317	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8O
ALDH5A1	P51649	290	338	321	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8N
ALDH5A1	P51649	290	338	334	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W8P
SSH1	Q8WYL5	383	449	2	1049	Chain	ID=PRO_0000094841;Note=Protein phosphatase Slingshot homolog 1
SSH1	Q8WYL5	157	178	2	1049	Chain	ID=PRO_0000094841;Note=Protein phosphatase Slingshot homolog 1
SSH1	Q8WYL5	134	156	2	1049	Chain	ID=PRO_0000094841;Note=Protein phosphatase Slingshot homolog 1
SSH1	Q8WYL5	383	449	308	448	Domain	Note=Tyrosine-protein phosphatase
SSH1	Q8WYL5	383	449	393	393	Active site	Note=Phosphocysteine intermediate;Ontology_term=ECO:0000305;evidence=ECO:0000305
SSH1	Q8WYL5	157	178	1	312	Alternative sequence	ID=VSP_016311;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10718198;Dbxref=PMID:10718198
SSH1	Q8WYL5	134	156	1	312	Alternative sequence	ID=VSP_016311;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10718198;Dbxref=PMID:10718198
SSH1	Q8WYL5	157	178	135	157	Alternative sequence	ID=VSP_016315;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11832213;Dbxref=PMID:11832213
SSH1	Q8WYL5	134	156	135	157	Alternative sequence	ID=VSP_016315;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11832213;Dbxref=PMID:11832213
SSH1	Q8WYL5	383	449	245	1049	Alternative sequence	ID=VSP_016316;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11832213;Dbxref=PMID:11832213
SSH1	Q8WYL5	383	449	393	393	Mutagenesis	Note=Abrogates phosphatase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11832213,ECO:0000269|PubMed:12684437,ECO:0000269|PubMed:12807904,ECO:0000269|PubMed:15056216,ECO:0000269|PubMed:15159416,ECO:0000269|PubMed:15660133,ECO:0000269|PubMed:15671020,ECO:0000269|PubMed:16230460;Dbxref=PMID:11832213,PMID:12684437,PMID:12807904,PMID:15056216,PMID:15159416,PMID:15660133,PMID:15671020,PMID:16230460
SSH3	Q8TE77	155	178	2	659	Chain	ID=PRO_0000094845;Note=Protein phosphatase Slingshot homolog 3
SSH3	Q8TE77	179	200	2	659	Chain	ID=PRO_0000094845;Note=Protein phosphatase Slingshot homolog 3
SSH3	Q8TE77	201	263	2	659	Chain	ID=PRO_0000094845;Note=Protein phosphatase Slingshot homolog 3
SSH3	Q8TE77	295	338	2	659	Chain	ID=PRO_0000094845;Note=Protein phosphatase Slingshot homolog 3
SSH3	Q8TE77	354	402	2	659	Chain	ID=PRO_0000094845;Note=Protein phosphatase Slingshot homolog 3
SSH3	Q8TE77	295	338	328	468	Domain	Note=Tyrosine-protein phosphatase
SSH3	Q8TE77	354	402	328	468	Domain	Note=Tyrosine-protein phosphatase
SSH3	Q8TE77	155	178	1	330	Alternative sequence	ID=VSP_016330;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	179	200	1	330	Alternative sequence	ID=VSP_016330;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	201	263	1	330	Alternative sequence	ID=VSP_016330;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	295	338	1	330	Alternative sequence	ID=VSP_016330;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	295	338	283	547	Alternative sequence	ID=VSP_016333;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	354	402	283	547	Alternative sequence	ID=VSP_016333;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	295	338	331	360	Alternative sequence	ID=VSP_016334;Note=In isoform 5. RIFPHLYLGSEWNAANLEELQRNRVTHILN->MEGTMMMQQRPVLSQQHPSFILNSSPAHSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	354	402	331	360	Alternative sequence	ID=VSP_016334;Note=In isoform 5. RIFPHLYLGSEWNAANLEELQRNRVTHILN->MEGTMMMQQRPVLSQQHPSFILNSSPAHSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSH3	Q8TE77	201	263	239	239	Natural variant	ID=VAR_057132;Note=E->V;Dbxref=dbSNP:rs7114712
SSPN	Q14714	93	122	1	243	Chain	ID=PRO_0000072226;Note=Sarcospan
SSPN	Q14714	93	122	87	107	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSPN	Q14714	93	122	108	122	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSPN	Q14714	93	122	1	103	Alternative sequence	ID=VSP_046351;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSPN	Q14714	93	122	108	218	Alternative sequence	ID=VSP_004431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:9395445;Dbxref=PMID:11230166,PMID:9395445
SSR3	Q9UNL2	87	119	1	185	Chain	ID=PRO_0000191690;Note=Translocon-associated protein subunit gamma
SSR3	Q9UNL2	87	119	77	135	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSR3	Q9UNL2	87	119	105	105	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9DCF9
SSUH2	Q9Y2M2	153	174	1	353	Chain	ID=PRO_0000260082;Note=Protein SSUH2 homolog
SSUH2	Q9Y2M2	153	174	1	353	Chain	ID=PRO_0000260082;Note=Protein SSUH2 homolog
SSUH2	Q9Y2M2	153	174	155	218	Compositional bias	Note=Cys-rich
SSUH2	Q9Y2M2	153	174	155	218	Compositional bias	Note=Cys-rich
SULT1B1	O43704	49	92	1	296	Chain	ID=PRO_0000085161;Note=Sulfotransferase family cytosolic 1B member 1
SULT1B1	O43704	49	92	48	53	Nucleotide binding	Note=PAPS
SULT1B1	O43704	49	92	51	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL
SULT1B1	O43704	49	92	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL
SULT1B1	O43704	49	92	67	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL
SULT1B1	O43704	49	92	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL
SULT1B1	O43704	49	92	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5F
SUPT7L	O94864	5	139	1	414	Chain	ID=PRO_0000072233;Note=STAGA complex 65 subunit gamma
SUPT7L	O94864	5	139	108	108	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SUPT7L	O94864	5	139	5	140	Alternative sequence	ID=VSP_054839;Note=In isoform 3. RYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSANKPKPPTMLDIPSEPCSLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPLPSCPGSPPLPDDLLPLDCKNPNAPFQIRHSDPESDFYR->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNX8	Q9Y5X2	180	207	1	465	Chain	ID=PRO_0000213851;Note=Sorting nexin-8
SNX8	Q9Y5X2	180	207	73	181	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SLCO6A1	Q86UG4	205	267	1	719	Chain	ID=PRO_0000307642;Note=Solute carrier organic anion transporter family member 6A1
SLCO6A1	Q86UG4	205	267	1	719	Chain	ID=PRO_0000307642;Note=Solute carrier organic anion transporter family member 6A1
SLCO6A1	Q86UG4	205	267	197	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO6A1	Q86UG4	205	267	197	223	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO6A1	Q86UG4	205	267	224	254	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO6A1	Q86UG4	205	267	224	254	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO6A1	Q86UG4	205	267	255	274	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO6A1	Q86UG4	205	267	255	274	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO6A1	Q86UG4	205	267	206	267	Alternative sequence	ID=VSP_028753;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SLCO6A1	Q86UG4	205	267	206	267	Alternative sequence	ID=VSP_028753;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SORT1	Q99523	675	713	78	831	Chain	ID=PRO_0000033163;Note=Sortilin
SORT1	Q99523	675	713	78	755	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORT1	Q99523	675	713	612	756	Region	Note=Interactions with LRPAP1 and NGFB
SORT1	Q99523	675	713	684	684	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORT1	Q99523	675	713	668	723	Disulfide bond	.
SORT1	Q99523	675	713	675	688	Disulfide bond	.
SORT1	Q99523	675	713	702	740	Disulfide bond	.
SORT1	Q99523	675	713	673	675	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F6K
SORT1	Q99523	675	713	683	685	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F6K
SORT1	Q99523	675	713	696	704	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F6K
SORT1	Q99523	675	713	707	710	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F6K
SPAG1	Q07617	100	142	1	926	Chain	ID=PRO_0000106324;Note=Sperm-associated antigen 1
SPAG1	Q07617	512	562	1	926	Chain	ID=PRO_0000106324;Note=Sperm-associated antigen 1
SPAG1	Q07617	705	760	1	926	Chain	ID=PRO_0000106324;Note=Sperm-associated antigen 1
SPAG1	Q07617	100	142	1	926	Chain	ID=PRO_0000106324;Note=Sperm-associated antigen 1
SPAG1	Q07617	512	562	1	926	Chain	ID=PRO_0000106324;Note=Sperm-associated antigen 1
SPAG1	Q07617	705	760	1	926	Chain	ID=PRO_0000106324;Note=Sperm-associated antigen 1
SPAG1	Q07617	512	562	487	520	Repeat	Note=TPR 5
SPAG1	Q07617	512	562	487	520	Repeat	Note=TPR 5
SPAG1	Q07617	512	562	522	554	Repeat	Note=TPR 6
SPAG1	Q07617	512	562	522	554	Repeat	Note=TPR 6
SPAG1	Q07617	705	760	692	724	Repeat	Note=TPR 9
SPAG1	Q07617	705	760	692	724	Repeat	Note=TPR 9
SPAG1	Q07617	512	562	417	926	Alternative sequence	ID=VSP_054291;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPAG1	Q07617	705	760	417	926	Alternative sequence	ID=VSP_054291;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPAG1	Q07617	512	562	417	926	Alternative sequence	ID=VSP_054291;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPAG1	Q07617	705	760	417	926	Alternative sequence	ID=VSP_054291;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPTLC1	O15269	230	260	1	473	Chain	ID=PRO_0000163853;Note=Serine palmitoyltransferase 1
SPTLC1	O15269	230	260	37	473	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTLC1	O15269	230	260	144	473	Alternative sequence	ID=VSP_043128;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPTLC1	O15269	230	260	239	239	Natural variant	ID=VAR_036610;Note=In a breast cancer sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs542876370,PMID:16959974
SPTLC3	Q9NUV7	39	101	1	552	Chain	ID=PRO_0000079426;Note=Serine palmitoyltransferase 3
SPTLC3	Q9NUV7	39	101	59	79	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
U2SURP	O15042	848	885	2	1029	Chain	ID=PRO_0000280070;Note=U2 snRNP-associated SURP motif-containing protein
U2SURP	O15042	925	983	2	1029	Chain	ID=PRO_0000280070;Note=U2 snRNP-associated SURP motif-containing protein
U2SURP	O15042	848	885	837	915	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
U2SURP	O15042	848	885	762	917	Compositional bias	Note=Glu-rich
U2SURP	O15042	925	983	922	1001	Compositional bias	Note=Arg/Ser-rich
U2SURP	O15042	925	983	931	931	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
U2SURP	O15042	925	983	946	946	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
U2SURP	O15042	925	983	948	948	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TMEM8A	Q9HCN3	634	673	35	771	Chain	ID=PRO_0000022539;Note=Post-GPI attachment to proteins factor 6
TMEM8A	Q9HCN3	585	634	35	771	Chain	ID=PRO_0000022539;Note=Post-GPI attachment to proteins factor 6
TMEM8A	Q9HCN3	585	634	569	589	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	585	634	590	605	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	585	634	606	626	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	585	634	627	629	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	634	673	630	650	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	585	634	630	650	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	634	673	651	653	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	634	673	654	674	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8A	Q9HCN3	585	634	588	588	Mutagenesis	Note=Abolishes shedding of TDGF1. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27881714;Dbxref=PMID:27881714
TMEM8A	Q9HCN3	585	634	610	610	Mutagenesis	Note=Abolishes shedding of TDGF1. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27881714;Dbxref=PMID:27881714
TMEM8A	Q9HCN3	634	673	654	654	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM8B	A6NDV4	322	361	1	472	Chain	ID=PRO_0000333039;Note=Transmembrane protein 8B
TMEM8B	A6NDV4	322	361	1	472	Chain	ID=PRO_0000333039;Note=Transmembrane protein 8B
TMEM8B	A6NDV4	322	361	316	336	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8B	A6NDV4	322	361	316	336	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8B	A6NDV4	322	361	337	342	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8B	A6NDV4	322	361	337	342	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8B	A6NDV4	322	361	343	363	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8B	A6NDV4	322	361	343	363	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM8B	A6NDV4	322	361	274	337	Alternative sequence	ID=VSP_033452;Note=In isoform 2 and isoform 3. FYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQ->VCGGVCILSLGACAWWWVTVCISTTFSEGLGMSVPSLCLLQTETAVLPKLSCIDNGHFCKTHWSK;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11565907,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:11565907,PMID:14702039,PMID:15489334
TMEM8B	A6NDV4	322	361	274	337	Alternative sequence	ID=VSP_033452;Note=In isoform 2 and isoform 3. FYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQ->VCGGVCILSLGACAWWWVTVCISTTFSEGLGMSVPSLCLLQTETAVLPKLSCIDNGHFCKTHWSK;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11565907,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:11565907,PMID:14702039,PMID:15489334
TMEM8B	A6NDV4	322	361	338	472	Alternative sequence	ID=VSP_033453;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11565907,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:11565907,PMID:14702039,PMID:15489334
TMEM8B	A6NDV4	322	361	338	472	Alternative sequence	ID=VSP_033453;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11565907,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:11565907,PMID:14702039,PMID:15489334
SSR2	P43308	121	147	18	183	Chain	ID=PRO_0000033290;Note=Translocon-associated protein subunit beta
SSR2	P43308	121	147	18	183	Chain	ID=PRO_0000033290;Note=Translocon-associated protein subunit beta
SSR2	P43308	121	147	18	149	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSR2	P43308	121	147	18	149	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNNI2	P48788	62	92	2	182	Chain	ID=PRO_0000186143;Note=Troponin I%2C fast skeletal muscle
TNNI2	P48788	62	92	2	182	Chain	ID=PRO_0000186143;Note=Troponin I%2C fast skeletal muscle
TNNI2	P48788	62	92	2	182	Chain	ID=PRO_0000186143;Note=Troponin I%2C fast skeletal muscle
TNFRSF9	Q07011	181	226	24	255	Chain	ID=PRO_0000034577;Note=Tumor necrosis factor receptor superfamily member 9
TNFRSF9	Q07011	33	69	24	255	Chain	ID=PRO_0000034577;Note=Tumor necrosis factor receptor superfamily member 9
TNFRSF9	Q07011	181	226	24	186	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF9	Q07011	33	69	24	186	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF9	Q07011	181	226	187	213	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF9	Q07011	181	226	214	255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF9	Q07011	33	69	24	45	Repeat	Note=TNFR-Cys 1
TNFRSF9	Q07011	33	69	47	86	Repeat	Note=TNFR-Cys 2
TNFRSF9	Q07011	181	226	214	255	Region	Note=Interaction with LRR-1
TNFRSF9	Q07011	33	69	28	37	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF9	Q07011	33	69	31	45	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF9	Q07011	33	69	48	62	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF9	Q07011	33	69	65	78	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF9	Q07011	33	69	68	86	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF9	Q07011	33	69	56	56	Natural variant	ID=VAR_018920;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs9657963
TNFRSF9	Q07011	33	69	35	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BWV
TNFRSF9	Q07011	33	69	39	41	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BWV
TNFRSF9	Q07011	33	69	45	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BWV
TNFRSF9	Q07011	33	69	55	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BWV
TNFRSF9	Q07011	33	69	60	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BWV
STK33	Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
STK33	Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
STK33	Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
STK33	Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
STK33	Q9BYT3	382	448	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
STK33	Q9BYT3	75	113	1	514	Chain	ID=PRO_0000232644;Note=Serine/threonine-protein kinase 33
STK33	Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
STK33	Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
STK33	Q9BYT3	382	448	443	446	Compositional bias	Note=Poly-Glu
STK33	Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q924X7
STK33	Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q924X7
STK33	Q9BYT3	382	448	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q924X7
STK33	Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STK33	Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STK33	Q9BYT3	382	448	383	448	Alternative sequence	ID=VSP_017939;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STK33	Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
STK33	Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
STK33	Q9BYT3	75	113	98	98	Natural variant	ID=VAR_041172;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34525052,PMID:17344846
STK33	Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
STK33	Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
STK33	Q9BYT3	382	448	436	436	Natural variant	ID=VAR_041174;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3751096,PMID:17344846
STK33	Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
STK33	Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
STK33	Q9BYT3	382	448	437	437	Natural variant	ID=VAR_041175;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3751095,PMID:17344846
STK33	Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK33	Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK33	Q9BYT3	382	448	436	437	Sequence conflict	Note=DA->ET;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK36	Q9NRP7	800	837	1	1315	Chain	ID=PRO_0000229020;Note=Serine/threonine-protein kinase 36
STK36	Q9NRP7	800	837	1	1315	Chain	ID=PRO_0000229020;Note=Serine/threonine-protein kinase 36
STK36	Q9NRP7	800	837	816	816	Natural variant	ID=VAR_041188;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34271431,PMID:17344846
STK36	Q9NRP7	800	837	816	816	Natural variant	ID=VAR_041188;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34271431,PMID:17344846
STAT6	P42226	720	741	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	581	630	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	363	404	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	720	741	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	581	630	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	363	404	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	720	741	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	581	630	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	363	404	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	720	741	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	581	630	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	363	404	2	847	Chain	ID=PRO_0000182433;Note=Signal transducer and activator of transcription 6
STAT6	P42226	581	630	517	632	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT6	P42226	581	630	517	632	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT6	P42226	581	630	517	632	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT6	P42226	581	630	517	632	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT6	P42226	720	741	733	733	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT6	P42226	720	741	733	733	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT6	P42226	720	741	733	733	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT6	P42226	720	741	733	733	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT6	P42226	363	404	355	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	355	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	355	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	355	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	363	404	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	363	404	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	363	404	379	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	363	404	384	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	384	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	384	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	384	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	401	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	401	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	401	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	363	404	401	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	584	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	584	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	584	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	584	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	594	599	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	594	599	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	594	599	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	594	599	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	602	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	602	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	602	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	602	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	616	618	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	616	618	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	616	618	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	616	618	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	621	624	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	621	624	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	621	624	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	621	624	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5U
STAT6	P42226	581	630	625	628	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	581	630	625	628	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	581	630	625	628	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STAT6	P42226	581	630	625	628	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y5W
STPG2	Q8N412	311	348	1	459	Chain	ID=PRO_0000311960;Note=Sperm-tail PG-rich repeat-containing protein 2
STRBP	Q96SI9	632	647	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	544	591	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	499	544	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	446	499	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	209	241	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	632	647	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	544	591	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	499	544	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	446	499	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	209	241	1	672	Chain	ID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
STRBP	Q96SI9	209	241	5	363	Domain	Note=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
STRBP	Q96SI9	209	241	5	363	Domain	Note=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
STRBP	Q96SI9	446	499	387	453	Domain	Note=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
STRBP	Q96SI9	446	499	387	453	Domain	Note=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
STRBP	Q96SI9	544	591	510	576	Domain	Note=DRBM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
STRBP	Q96SI9	499	544	510	576	Domain	Note=DRBM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
STRBP	Q96SI9	544	591	510	576	Domain	Note=DRBM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
STRBP	Q96SI9	499	544	510	576	Domain	Note=DRBM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
STRBP	Q96SI9	544	591	584	587	Compositional bias	Note=Poly-Lys
STRBP	Q96SI9	544	591	584	587	Compositional bias	Note=Poly-Lys
STRBP	Q96SI9	446	499	436	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
STRBP	Q96SI9	446	499	436	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
STX17	P56962	41	63	2	302	Chain	ID=PRO_0000210228;Note=Syntaxin-17
STX17	P56962	41	63	2	302	Chain	ID=PRO_0000210228;Note=Syntaxin-17
STX17	P56962	41	63	2	302	Chain	ID=PRO_0000210228;Note=Syntaxin-17
STX17	P56962	41	63	2	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX17	P56962	41	63	2	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX17	P56962	41	63	2	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX17	P56962	41	63	53	123	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STX17	P56962	41	63	53	123	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STX17	P56962	41	63	53	123	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STX17	P56962	41	63	41	41	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STX17	P56962	41	63	41	41	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STX17	P56962	41	63	41	41	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
STT3B	Q8TCJ2	141	237	2	826	Chain	ID=PRO_0000246001;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
STT3B	Q8TCJ2	237	259	2	826	Chain	ID=PRO_0000246001;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
STT3B	Q8TCJ2	325	374	2	826	Chain	ID=PRO_0000246001;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
STT3B	Q8TCJ2	691	729	2	826	Chain	ID=PRO_0000246001;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
STT3B	Q8TCJ2	729	800	2	826	Chain	ID=PRO_0000246001;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
STT3B	Q8TCJ2	141	237	87	173	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	141	237	174	192	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	141	237	193	194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	141	237	195	212	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	141	237	213	223	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	141	237	224	243	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	237	259	224	243	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	237	259	244	245	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	237	259	246	260	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	325	374	322	341	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	325	374	342	350	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	325	374	351	371	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STT3B	Q8TCJ2	325	374	372	410	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	691	729	553	826	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	729	800	553	826	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3B	Q8TCJ2	141	237	221	223	Motif	Note=DXD motif 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3B	Q8TCJ2	141	237	221	221	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3B	Q8TCJ2	141	237	223	223	Metal binding	Note=Manganese;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3B	Q8TCJ2	141	237	214	214	Site	Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
RBPJ	Q06330	309	361	1	500	Chain	ID=PRO_0000208567;Note=Recombining binding protein suppressor of hairless
RBPJ	Q06330	309	361	1	500	Chain	ID=PRO_0000208567;Note=Recombining binding protein suppressor of hairless
RBPJ	Q06330	309	361	355	445	Domain	Note=IPT/TIG
RBPJ	Q06330	309	361	355	445	Domain	Note=IPT/TIG
RBPJ	Q06330	309	361	334	334	Natural variant	ID=VAR_028995;Note=D->H;Dbxref=dbSNP:rs1064376
RBPJ	Q06330	309	361	334	334	Natural variant	ID=VAR_028995;Note=D->H;Dbxref=dbSNP:rs1064376
RBPJ	Q06330	309	361	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F8X
RBPJ	Q06330	309	361	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F8X
RBPJ	Q06330	309	361	328	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F8X
RBPJ	Q06330	309	361	328	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F8X
RBPJ	Q06330	309	361	343	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NBN
RBPJ	Q06330	309	361	343	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NBN
RBPJ	Q06330	309	361	356	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F8X
RBPJ	Q06330	309	361	356	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F8X
STK32B	Q9NY57	157	187	1	414	Chain	ID=PRO_0000232413;Note=Serine/threonine-protein kinase 32B
STK32B	Q9NY57	261	303	1	414	Chain	ID=PRO_0000232413;Note=Serine/threonine-protein kinase 32B
STK32B	Q9NY57	157	187	23	283	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK32B	Q9NY57	261	303	23	283	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STAB1	Q9NY15	162	194	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	663	684	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	961	993	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	1149	1182	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	1226	1269	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	1587	1603	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	1804	1833	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	1969	2019	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	2430	2465	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	2465	2514	26	2570	Chain	ID=PRO_0000007710;Note=Stabilin-1
STAB1	Q9NY15	162	194	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	663	684	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	961	993	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1149	1182	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1226	1269	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1587	1603	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1804	1833	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1969	2019	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	2430	2465	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	2465	2514	26	2478	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	2465	2514	2479	2499	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	2465	2514	2500	2570	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	162	194	156	193	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000305
STAB1	Q9NY15	961	993	947	986	Domain	Note=EGF-like 9;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000305
STAB1	Q9NY15	961	993	988	1118	Domain	Note=FAS1 3;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00082,ECO:0000305
STAB1	Q9NY15	1149	1182	1128	1253	Domain	Note=FAS1 4;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00082,ECO:0000305
STAB1	Q9NY15	1226	1269	1128	1253	Domain	Note=FAS1 4;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00082,ECO:0000305
STAB1	Q9NY15	1587	1603	1582	1708	Domain	Note=FAS1 5;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00082,ECO:0000305
STAB1	Q9NY15	1804	1833	1724	1864	Domain	Note=FAS1 6;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00082,ECO:0000305
STAB1	Q9NY15	1969	2019	1966	2031	Domain	Note=Laminin EGF-like 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAB1	Q9NY15	2430	2465	2322	2459	Domain	Note=FAS1 7;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00082,ECO:0000305
STAB1	Q9NY15	663	684	673	673	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1149	1182	1170	1170	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	1149	1182	1178	1178	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
STAB1	Q9NY15	162	194	160	171	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	162	194	164	181	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	162	194	183	192	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	961	993	951	964	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	961	993	958	974	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	1969	2019	1971	1985	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	1969	2019	1979	1995	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	1969	2019	1997	2006	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	1969	2019	2018	2029	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAB1	Q9NY15	961	993	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	1149	1182	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	1226	1269	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	1587	1603	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	1804	1833	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	1969	2019	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	2430	2465	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	2465	2514	804	2570	Alternative sequence	ID=VSP_050765;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12077138;Dbxref=PMID:12077138
STAB1	Q9NY15	663	684	672	672	Natural variant	ID=VAR_060338;Note=L->M;Dbxref=dbSNP:rs12636502
STAB1	Q9NY15	1804	1833	1833	1833	Natural variant	ID=VAR_060340;Note=A->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11829752,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9039502;Dbxref=dbSNP:rs7630214,PMID:11829752,PMID:15489334,PMID:9039502
STAB1	Q9NY15	2465	2514	2506	2506	Natural variant	ID=VAR_019078;Note=M->T;Dbxref=dbSNP:rs13303
STOM	P27105	107	175	1	288	Chain	ID=PRO_0000094027;Note=Erythrocyte band 7 integral membrane protein
STOM	P27105	107	175	55	288	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STOM	P27105	107	175	161	161	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54116
STOM	P27105	107	175	55	219	Alternative sequence	ID=VSP_044669;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STXBP2	Q15833	342	369	1	593	Chain	ID=PRO_0000206281;Note=Syntaxin-binding protein 2
STXBP2	Q15833	452	484	1	593	Chain	ID=PRO_0000206281;Note=Syntaxin-binding protein 2
STXBP2	Q15833	452	484	477	477	Natural variant	ID=VAR_063819;Note=In FHL5%3B leads to a complete loss of the ability to interact with STX11. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19804848,ECO:0000269|PubMed:19884660;Dbxref=dbSNP:rs121918540,PMID:19804848,PMID:19884660
STXBP2	Q15833	342	369	348	348	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP2	Q15833	342	369	333	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCA
STXBP2	Q15833	342	369	360	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCA
STXBP2	Q15833	452	484	478	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CCA
STRN3	Q13033	629	676	1	797	Chain	ID=PRO_0000051236;Note=Striatin-3
STRN3	Q13033	366	413	1	797	Chain	ID=PRO_0000051236;Note=Striatin-3
STRN3	Q13033	329	366	1	797	Chain	ID=PRO_0000051236;Note=Striatin-3
STRN3	Q13033	329	366	335	335	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ERG2
STRN3	Q13033	366	413	330	413	Alternative sequence	ID=VSP_006786;Note=In isoform Alpha. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7864889;Dbxref=PMID:14702039,PMID:15489334,PMID:7864889
STRN3	Q13033	329	366	330	413	Alternative sequence	ID=VSP_006786;Note=In isoform Alpha. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7864889;Dbxref=PMID:14702039,PMID:15489334,PMID:7864889
SUSD4	Q5VX71	49	120	42	490	Chain	ID=PRO_0000251975;Note=Sushi domain-containing protein 4
SUSD4	Q5VX71	49	120	42	319	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SUSD4	Q5VX71	49	120	55	119	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SUSD4	Q5VX71	49	120	120	179	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SUSD4	Q5VX71	49	120	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SUSD4	Q5VX71	49	120	57	99	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SUSD4	Q5VX71	49	120	85	117	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SUZ12	Q15022	129	151	1	739	Chain	ID=PRO_0000047057;Note=Polycomb protein SUZ12
SUZ12	Q15022	129	151	128	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
SUZ12	Q15022	129	151	134	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
SUZ12	Q15022	129	151	137	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
TRPC4AP	Q8TEL6	406	450	2	797	Chain	ID=PRO_0000072641;Note=Short transient receptor potential channel 4-associated protein
TRPC4AP	Q8TEL6	288	350	2	797	Chain	ID=PRO_0000072641;Note=Short transient receptor potential channel 4-associated protein
TRPC4AP	Q8TEL6	176	219	2	797	Chain	ID=PRO_0000072641;Note=Short transient receptor potential channel 4-associated protein
TRPC4AP	Q8TEL6	99	138	2	797	Chain	ID=PRO_0000072641;Note=Short transient receptor potential channel 4-associated protein
TRPC4AP	Q8TEL6	288	350	2	400	Region	Note=Interaction with TNFRSF1A;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRPC4AP	Q8TEL6	176	219	2	400	Region	Note=Interaction with TNFRSF1A;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRPC4AP	Q8TEL6	99	138	2	400	Region	Note=Interaction with TNFRSF1A;Ontology_term=ECO:0000250;evidence=ECO:0000250
SYCP1	Q15431	97	152	1	976	Chain	ID=PRO_0000072362;Note=Synaptonemal complex protein 1
SYCP1	Q15431	853	901	1	976	Chain	ID=PRO_0000072362;Note=Synaptonemal complex protein 1
SYCP1	Q15431	97	152	1	976	Chain	ID=PRO_0000072362;Note=Synaptonemal complex protein 1
SYCP1	Q15431	853	901	1	976	Chain	ID=PRO_0000072362;Note=Synaptonemal complex protein 1
SYCP1	Q15431	97	152	107	798	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SYCP1	Q15431	97	152	107	798	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SYCP1	Q15431	97	152	117	120	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYCP1	Q15431	97	152	117	120	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYCP1	Q15431	853	901	880	883	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYCP1	Q15431	853	901	880	883	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SYCP1	Q15431	97	152	12	100	Compositional bias	Note=Asp/Glu-rich (acidic)
SYCP1	Q15431	97	152	12	100	Compositional bias	Note=Asp/Glu-rich (acidic)
SYCP1	Q15431	97	152	106	106	Sequence conflict	Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYCP1	Q15431	97	152	106	106	Sequence conflict	Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SYCP1	Q15431	97	152	101	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F5X
SYCP1	Q15431	97	152	101	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F5X
TRAPPC6B	Q86SZ2	89	117	1	158	Chain	ID=PRO_0000211587;Note=Trafficking protein particle complex subunit 6B
TRAPPC6B	Q86SZ2	89	117	90	117	Alternative sequence	ID=VSP_009659;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TRAPPC6B	Q86SZ2	89	117	42	158	Natural variant	ID=VAR_080729;Note=In NEDMEBA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838
TRAPPC6B	Q86SZ2	89	117	91	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BJN
TRAPPC6B	Q86SZ2	89	117	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BJN
TRAPPC6B	Q86SZ2	89	117	116	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BJN
SORCS3	Q9UPU3	404	434	34	1222	Chain	ID=PRO_0000033174;Note=VPS10 domain-containing receptor SorCS3
SORCS3	Q9UPU3	404	434	34	1125	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SOBP	A7XYQ1	78	140	1	873	Chain	ID=PRO_0000312232;Note=Sine oculis-binding protein homolog
SOBP	A7XYQ1	191	223	1	873	Chain	ID=PRO_0000312232;Note=Sine oculis-binding protein homolog
SOBP	A7XYQ1	191	223	216	256	Zinc finger	Note=FCS-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SUPT16H	Q9Y5B9	973	999	2	1047	Chain	ID=PRO_0000245169;Note=FACT complex subunit SPT16
SUPT16H	Q9Y5B9	161	210	2	1047	Chain	ID=PRO_0000245169;Note=FACT complex subunit SPT16
SUPT16H	Q9Y5B9	53	110	2	1047	Chain	ID=PRO_0000245169;Note=FACT complex subunit SPT16
SUPT16H	Q9Y5B9	973	999	926	1011	Compositional bias	Note=Glu-rich (acidic)
SUPT16H	Q9Y5B9	161	210	188	188	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
SUPT16H	Q9Y5B9	161	210	196	196	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SUPT16H	Q9Y5B9	973	999	979	979	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692
SUPT16H	Q9Y5B9	973	999	982	982	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163
SUPT16H	Q9Y5B9	973	999	986	986	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SUPT16H	Q9Y5B9	53	110	48	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	53	110	62	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	53	110	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	53	110	79	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	53	110	95	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	53	110	103	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	53	110	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	161	210	160	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	161	210	165	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	161	210	177	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SUPT16H	Q9Y5B9	161	210	198	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B
SPATA7	Q9P0W8	31	63	1	599	Chain	ID=PRO_0000072104;Note=Spermatogenesis-associated protein 7
SPATA7	Q9P0W8	343	360	1	599	Chain	ID=PRO_0000072104;Note=Spermatogenesis-associated protein 7
SPATA7	Q9P0W8	31	63	32	63	Alternative sequence	ID=VSP_008341;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334;Dbxref=PMID:11230166,PMID:15489334
SPATA9	Q9BWV2	50	126	1	254	Chain	ID=PRO_0000278446;Note=Spermatogenesis-associated protein 9
SPATA9	Q9BWV2	50	126	51	126	Alternative sequence	ID=VSP_023282;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPATA9	Q9BWV2	50	126	98	98	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA9	Q9BWV2	50	126	102	102	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM101	Q96IK0	106	155	1	257	Chain	ID=PRO_0000240864;Note=Transmembrane protein 101
TMEM101	Q96IK0	106	155	1	257	Chain	ID=PRO_0000240864;Note=Transmembrane protein 101
TMEM101	Q96IK0	106	155	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM101	Q96IK0	106	155	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM101	Q96IK0	106	155	139	159	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM101	Q96IK0	106	155	139	159	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM108	Q6UXF1	13	483	1	575	Chain	ID=PRO_0000243913;Note=Transmembrane protein 108
TMEM108	Q6UXF1	13	483	1	575	Chain	ID=PRO_0000243913;Note=Transmembrane protein 108
TMEM108	Q6UXF1	13	483	9	29	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM108	Q6UXF1	13	483	9	29	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM108	Q6UXF1	13	483	469	489	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM108	Q6UXF1	13	483	469	489	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM108	Q6UXF1	13	483	31	169	Region	Note=Interaction with SH3GL2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHE4
TMEM108	Q6UXF1	13	483	31	169	Region	Note=Interaction with SH3GL2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHE4
TMEM108	Q6UXF1	13	483	173	407	Region	Note=Interaction with DST (isoform 1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHE4
TMEM108	Q6UXF1	13	483	173	407	Region	Note=Interaction with DST (isoform 1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BHE4
TMEM108	Q6UXF1	13	483	68	187	Compositional bias	Note=Pro-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00015
TMEM108	Q6UXF1	13	483	68	187	Compositional bias	Note=Pro-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00015
TMEM108	Q6UXF1	13	483	84	84	Natural variant	ID=VAR_051427;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214970,ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs34111099,PMID:11214970,PMID:12975309
TMEM108	Q6UXF1	13	483	84	84	Natural variant	ID=VAR_051427;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214970,ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs34111099,PMID:11214970,PMID:12975309
TMEM108	Q6UXF1	13	483	108	108	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM108	Q6UXF1	13	483	108	108	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3PXD2A	Q5TCZ1	436	476	1	1133	Chain	ID=PRO_0000278488;Note=SH3 and PX domain-containing protein 2A
SH3PXD2A	Q5TCZ1	239	267	1	1133	Chain	ID=PRO_0000278488;Note=SH3 and PX domain-containing protein 2A
SH3PXD2A	Q5TCZ1	142	157	1	1133	Chain	ID=PRO_0000278488;Note=SH3 and PX domain-containing protein 2A
SH3PXD2A	Q5TCZ1	24	51	1	1133	Chain	ID=PRO_0000278488;Note=SH3 and PX domain-containing protein 2A
SH3PXD2A	Q5TCZ1	24	51	4	128	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SH3PXD2A	Q5TCZ1	239	267	266	325	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3PXD2A	Q5TCZ1	436	476	448	507	Domain	Note=SH3 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3PXD2A	Q5TCZ1	239	267	256	256	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O89032
SH3PXD2A	Q5TCZ1	142	157	1	165	Alternative sequence	ID=VSP_023312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477
SH3PXD2A	Q5TCZ1	24	51	1	165	Alternative sequence	ID=VSP_023312;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477
SH3PXD2A	Q5TCZ1	239	267	240	267	Alternative sequence	ID=VSP_023313;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477
SH3PXD2A	Q5TCZ1	24	51	42	42	Mutagenesis	Note=Loss of binding to (PtdIns(3)P) and (PtdIns(3%2C4)P2). R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12615925;Dbxref=PMID:12615925
SH3PXD2B	A1X283	187	222	1	911	Chain	ID=PRO_0000312201;Note=SH3 and PX domain-containing protein 2B
SH3PXD2B	A1X283	142	187	1	911	Chain	ID=PRO_0000312201;Note=SH3 and PX domain-containing protein 2B
SH3PXD2B	A1X283	187	222	152	211	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3PXD2B	A1X283	142	187	152	211	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3PXD2B	A1X283	187	222	221	280	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TMEM144	Q7Z5S9	300	318	1	345	Chain	ID=PRO_0000288971;Note=Transmembrane protein 144
TMEM144	Q7Z5S9	300	318	292	312	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM144	Q7Z5S9	300	318	170	345	Alternative sequence	ID=VSP_025851;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TM6SF1	Q9BZW5	236	267	1	370	Chain	ID=PRO_0000181833;Note=Transmembrane 6 superfamily member 1
TM6SF1	Q9BZW5	236	267	218	238	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM6SF1	Q9BZW5	236	267	216	350	Domain	Note=EXPERA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01087
TM6SF1	Q9BZW5	236	267	237	267	Alternative sequence	ID=VSP_045697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SPNS3	Q6ZMD2	257	307	1	512	Chain	ID=PRO_0000305046;Note=Protein spinster homolog 3
SPNS3	Q6ZMD2	393	426	1	512	Chain	ID=PRO_0000305046;Note=Protein spinster homolog 3
SPNS3	Q6ZMD2	257	307	260	280	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPNS3	Q6ZMD2	393	426	377	397	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPNS3	Q6ZMD2	393	426	411	431	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPNS3	Q6ZMD2	257	307	293	293	Natural variant	ID=VAR_035158;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs34457931,PMID:14702039
SPNS3	Q6ZMD2	393	426	417	417	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM87A	Q8NBN3	153	168	22	555	Chain	ID=PRO_0000270751;Note=Transmembrane protein 87A
TMEM87A	Q8NBN3	153	168	22	225	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM87A	Q8NBN3	153	168	157	157	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
TMEM87A	Q8NBN3	153	168	160	160	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
SPATA17	Q96L03	23	52	1	361	Chain	ID=PRO_0000265933;Note=Spermatogenesis-associated protein 17
SPATA17	Q96L03	80	97	1	361	Chain	ID=PRO_0000265933;Note=Spermatogenesis-associated protein 17
SPATA17	Q96L03	173	241	1	361	Chain	ID=PRO_0000265933;Note=Spermatogenesis-associated protein 17
SPATA17	Q96L03	23	52	32	61	Domain	Note=IQ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
SPATA17	Q96L03	80	97	55	84	Domain	Note=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
SPATA17	Q96L03	80	97	91	120	Domain	Note=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
SEPHS1	P49903	250	321	2	392	Chain	ID=PRO_0000127648;Note=Selenide%2C water dikinase 1
SEPHS1	P49903	99	135	2	392	Chain	ID=PRO_0000127648;Note=Selenide%2C water dikinase 1
SEPHS1	P49903	250	321	267	273	Nucleotide binding	Note=ATP
SEPHS1	P49903	99	135	110	110	Binding site	Note=ATP
SEPHS1	P49903	250	321	251	321	Alternative sequence	ID=VSP_046702;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20471958;Dbxref=PMID:20471958
SEPHS1	P49903	250	321	268	268	Mutagenesis	Note=No change in ATP-binding. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7665581;Dbxref=PMID:7665581
SEPHS1	P49903	250	321	270	270	Mutagenesis	Note=No change in ATP-binding. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7665581;Dbxref=PMID:7665581
SEPHS1	P49903	250	321	273	273	Mutagenesis	Note=Loss of ATP-binding. G->A%2CD%2CV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7665581;Dbxref=PMID:7665581
SEPHS1	P49903	250	321	274	274	Mutagenesis	Note=Reduced ATP-binding. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7665581;Dbxref=PMID:7665581
SEPHS1	P49903	250	321	274	274	Mutagenesis	Note=Increased ATP-binding. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7665581;Dbxref=PMID:7665581
SEPHS1	P49903	250	321	260	260	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEPHS1	P49903	99	135	96	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	99	135	120	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	99	135	134	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	249	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	262	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	270	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	283	296	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	299	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	306	308	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SEPHS1	P49903	250	321	312	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FD5
SPTBN4	Q9H254	196	222	1	2564	Chain	ID=PRO_0000073465;Note=Spectrin beta chain%2C non-erythrocytic 4
SPTBN4	Q9H254	2440	2497	1	2564	Chain	ID=PRO_0000073465;Note=Spectrin beta chain%2C non-erythrocytic 4
SPTBN4	Q9H254	196	222	1	2564	Chain	ID=PRO_0000073465;Note=Spectrin beta chain%2C non-erythrocytic 4
SPTBN4	Q9H254	2440	2497	1	2564	Chain	ID=PRO_0000073465;Note=Spectrin beta chain%2C non-erythrocytic 4
SPTBN4	Q9H254	196	222	180	285	Domain	Note=Calponin-homology (CH) 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
SPTBN4	Q9H254	196	222	180	285	Domain	Note=Calponin-homology (CH) 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
SPTBN4	Q9H254	2440	2497	2418	2527	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SPTBN4	Q9H254	2440	2497	2418	2527	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SPTBN4	Q9H254	196	222	1	282	Region	Note=Actin-binding
SPTBN4	Q9H254	196	222	1	282	Region	Note=Actin-binding
SPTBN4	Q9H254	196	222	1	1324	Alternative sequence	ID=VSP_046383;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11294830;Dbxref=PMID:11294830
SPTBN4	Q9H254	196	222	1	1324	Alternative sequence	ID=VSP_046383;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11294830;Dbxref=PMID:11294830
SPTBN4	Q9H254	196	222	1	1257	Alternative sequence	ID=VSP_000723;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086001;Dbxref=PMID:11086001
SPTBN4	Q9H254	196	222	1	1257	Alternative sequence	ID=VSP_000723;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086001;Dbxref=PMID:11086001
SPTBN4	Q9H254	2440	2497	1310	2564	Alternative sequence	ID=VSP_000726;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086001;Dbxref=PMID:11086001
SPTBN4	Q9H254	2440	2497	1310	2564	Alternative sequence	ID=VSP_000726;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086001;Dbxref=PMID:11086001
SPTBN4	Q9H254	2440	2497	2003	2564	Alternative sequence	ID=VSP_046385;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11294830;Dbxref=PMID:11294830
SPTBN4	Q9H254	2440	2497	2003	2564	Alternative sequence	ID=VSP_046385;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11294830;Dbxref=PMID:11294830
SPTBN4	Q9H254	2440	2497	2155	2564	Alternative sequence	ID=VSP_000728;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086001;Dbxref=PMID:11086001
SPTBN4	Q9H254	2440	2497	2155	2564	Alternative sequence	ID=VSP_000728;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086001;Dbxref=PMID:11086001
SPTBN4	Q9H254	2440	2497	533	2564	Natural variant	ID=VAR_079212;Note=In CMND%3B decreased protein abundance in patient cells homozygous for the mutation. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28540413;Dbxref=PMID:28540413
SPTBN4	Q9H254	2440	2497	533	2564	Natural variant	ID=VAR_079212;Note=In CMND%3B decreased protein abundance in patient cells homozygous for the mutation. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28540413;Dbxref=PMID:28540413
SERGEF	Q9UGK8	228	281	1	458	Chain	ID=PRO_0000206649;Note=Secretion-regulating guanine nucleotide exchange factor
SERGEF	Q9UGK8	207	228	1	458	Chain	ID=PRO_0000206649;Note=Secretion-regulating guanine nucleotide exchange factor
SERGEF	Q9UGK8	169	207	1	458	Chain	ID=PRO_0000206649;Note=Secretion-regulating guanine nucleotide exchange factor
SERGEF	Q9UGK8	169	207	120	171	Repeat	Note=RCC1 3
SERGEF	Q9UGK8	228	281	172	230	Repeat	Note=RCC1 4
SERGEF	Q9UGK8	207	228	172	230	Repeat	Note=RCC1 4
SERGEF	Q9UGK8	169	207	172	230	Repeat	Note=RCC1 4
SERGEF	Q9UGK8	228	281	231	283	Repeat	Note=RCC1 5
SERAC1	Q96JX3	246	284	1	654	Chain	ID=PRO_0000274671;Note=Protein SERAC1
SERAC1	Q96JX3	118	162	1	654	Chain	ID=PRO_0000274671;Note=Protein SERAC1
SERAC1	Q96JX3	88	118	1	654	Chain	ID=PRO_0000274671;Note=Protein SERAC1
SERAC1	Q96JX3	246	284	168	654	Alternative sequence	ID=VSP_022858;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM52	Q8NDY8	43	56	33	209	Chain	ID=PRO_0000284057;Note=Transmembrane protein 52
TMEM52	Q8NDY8	43	56	56	76	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM52	Q8NDY8	43	56	2	57	Alternative sequence	ID=VSP_024420;Note=In isoform 2. ARGPLAARGLRLLLPLLPLLPLLPLPQVALGFADGSCDPSDQCPPQARWSSLWHVG->ERHCLLFILLTCLRWLCHDIPQGAGARWPRVSPVVEPCSPR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SRGAP3	O43295	141	162	1	1099	Chain	ID=PRO_0000056769;Note=SLIT-ROBO Rho GTPase-activating protein 3
SRGAP3	O43295	141	162	19	314	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077
SRFBP1	Q8NEF9	66	90	2	429	Chain	ID=PRO_0000320006;Note=Serum response factor-binding protein 1
SRFBP1	Q8NEF9	66	90	42	67	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SSRP1	Q08945	334	407	2	709	Chain	ID=PRO_0000048606;Note=FACT complex subunit SSRP1
SSRP1	Q08945	334	407	364	364	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SSRP1	Q08945	334	407	335	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	339	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	348	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	356	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	367	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	371	373	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	374	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	383	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	388	395	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
SSRP1	Q08945	334	407	400	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UMS
TNFSF8	P32971	79	103	1	234	Chain	ID=PRO_0000185499;Note=Tumor necrosis factor ligand superfamily member 8
TNFSF8	P32971	79	103	63	234	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFSF8	P32971	79	103	81	81	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNNT1	P13805	103	129	1	278	Chain	ID=PRO_0000186168;Note=Troponin T%2C slow skeletal muscle
TNNT1	P13805	64	103	1	278	Chain	ID=PRO_0000186168;Note=Troponin T%2C slow skeletal muscle
TNNT1	P13805	24	35	1	278	Chain	ID=PRO_0000186168;Note=Troponin T%2C slow skeletal muscle
TNNT1	P13805	24	35	25	35	Alternative sequence	ID=VSP_006639;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
TNFRSF8	P28908	418	436	19	595	Chain	ID=PRO_0000034573;Note=Tumor necrosis factor receptor superfamily member 8
TNFRSF8	P28908	418	436	408	595	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF8	P28908	418	436	1	463	Alternative sequence	ID=VSP_018900;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8839832;Dbxref=PMID:15489334,PMID:8839832
SOX6	P35712	577	655	1	828	Chain	ID=PRO_0000048729;Note=Transcription factor SOX-6
SOX6	P35712	326	367	1	828	Chain	ID=PRO_0000048729;Note=Transcription factor SOX-6
SOX6	P35712	148	178	1	828	Chain	ID=PRO_0000048729;Note=Transcription factor SOX-6
SOX6	P35712	577	655	621	689	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
SOX6	P35712	326	367	327	367	Alternative sequence	ID=VSP_039694;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334;Dbxref=PMID:11230166,PMID:15489334
SOX6	P35712	577	655	578	597	Alternative sequence	ID=VSP_039696;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11255018;Dbxref=PMID:11255018
SOX6	P35712	326	367	330	330	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SOX6	P35712	577	655	633	633	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINB4	P48594	204	256	1	390	Chain	ID=PRO_0000094104;Note=Serpin B4
SERPINB4	P48594	74	117	1	390	Chain	ID=PRO_0000094104;Note=Serpin B4
SERPINB5	P36952	56	102	1	375	Chain	ID=PRO_0000032486;Note=Serpin B5
SERPINB5	P36952	189	245	1	375	Chain	ID=PRO_0000032486;Note=Serpin B5
SERPINB5	P36952	56	102	99	99	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SERPINB5	P36952	189	245	190	231	Alternative sequence	ID=VSP_037145;Note=In isoform 2. TDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFIL->VCGAACSSKRSPIIDVKNDRDRVGHKSIPMRNLRARPAKCLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SERPINB5	P36952	189	245	232	375	Alternative sequence	ID=VSP_037146;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SERPINB5	P36952	56	102	66	66	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINB5	P36952	189	245	245	245	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINB5	P36952	56	102	48	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	56	102	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQG
SERPINB5	P36952	56	102	66	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	56	102	81	83	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	56	102	84	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	56	102	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	56	102	102	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	181	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	192	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	210	213	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	214	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	222	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	225	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
SERPINB5	P36952	189	245	239	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZ9
TMEM104	Q8NE00	115	142	1	496	Chain	ID=PRO_0000254178;Note=Transmembrane protein 104
TMEM104	Q8NE00	115	142	1	496	Chain	ID=PRO_0000254178;Note=Transmembrane protein 104
TMEM104	Q8NE00	115	142	58	146	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM104	Q8NE00	115	142	58	146	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VIPAS39	Q9H9C1	452	487	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	393	422	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	304	349	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	168	199	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	65	114	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	452	487	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	393	422	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	304	349	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	168	199	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	65	114	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	452	487	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	393	422	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	304	349	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	168	199	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	65	114	1	493	Chain	ID=PRO_0000089935;Note=Spermatogenesis-defective protein 39 homolog
VIPAS39	Q9H9C1	65	114	67	115	Alternative sequence	ID=VSP_043055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VIPAS39	Q9H9C1	65	114	67	115	Alternative sequence	ID=VSP_043055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VIPAS39	Q9H9C1	65	114	67	115	Alternative sequence	ID=VSP_043055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPEF2	Q9C093	138	195	1	1822	Chain	ID=PRO_0000299029;Note=Sperm flagellar protein 2
SPEF2	Q9C093	946	971	1	1822	Chain	ID=PRO_0000299029;Note=Sperm flagellar protein 2
SPEF2	Q9C093	1316	1359	1	1822	Chain	ID=PRO_0000299029;Note=Sperm flagellar protein 2
SPEF2	Q9C093	1610	1670	1	1822	Chain	ID=PRO_0000299029;Note=Sperm flagellar protein 2
SPEF2	Q9C093	1316	1359	1324	1676	Region	Note=Interaction with IFT20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19889948;Dbxref=PMID:19889948
SPEF2	Q9C093	1610	1670	1324	1676	Region	Note=Interaction with IFT20;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19889948;Dbxref=PMID:19889948
SPEF2	Q9C093	138	195	1	1483	Alternative sequence	ID=VSP_027521;Note=In isoform 4. MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKG->MPSQIGDRKWLHGLQAALQNFLKGYPAIVRQLHSAGRGKSDTSQKKPKELLESLLQADIVKFAHFLLDVMNVLSILSCVNKNRNSSIADIFATLESMLEMLQMYQTRLGPKERMVDSATHFHGNCLRGKENISAVRNIVLTHLIKRLQGCFRDASQNVVRATVIGSFKLWPTKINQEFGEKEVSILTAHYEPVLEAANVKLSEVDTEWSMLKLEIYARFQNIRKLTWDFVNSIYLHKYPNILTLVDLVLTLPASSAEAEHGFSQMKWTKSHMHAKIKAES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPEF2	Q9C093	946	971	1	1483	Alternative sequence	ID=VSP_027521;Note=In isoform 4. MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKG->MPSQIGDRKWLHGLQAALQNFLKGYPAIVRQLHSAGRGKSDTSQKKPKELLESLLQADIVKFAHFLLDVMNVLSILSCVNKNRNSSIADIFATLESMLEMLQMYQTRLGPKERMVDSATHFHGNCLRGKENISAVRNIVLTHLIKRLQGCFRDASQNVVRATVIGSFKLWPTKINQEFGEKEVSILTAHYEPVLEAANVKLSEVDTEWSMLKLEIYARFQNIRKLTWDFVNSIYLHKYPNILTLVDLVLTLPASSAEAEHGFSQMKWTKSHMHAKIKAES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPEF2	Q9C093	1316	1359	1	1483	Alternative sequence	ID=VSP_027521;Note=In isoform 4. MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKG->MPSQIGDRKWLHGLQAALQNFLKGYPAIVRQLHSAGRGKSDTSQKKPKELLESLLQADIVKFAHFLLDVMNVLSILSCVNKNRNSSIADIFATLESMLEMLQMYQTRLGPKERMVDSATHFHGNCLRGKENISAVRNIVLTHLIKRLQGCFRDASQNVVRATVIGSFKLWPTKINQEFGEKEVSILTAHYEPVLEAANVKLSEVDTEWSMLKLEIYARFQNIRKLTWDFVNSIYLHKYPNILTLVDLVLTLPASSAEAEHGFSQMKWTKSHMHAKIKAES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPEF2	Q9C093	946	971	515	1822	Alternative sequence	ID=VSP_027523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SPEF2	Q9C093	1316	1359	515	1822	Alternative sequence	ID=VSP_027523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SPEF2	Q9C093	1610	1670	515	1822	Alternative sequence	ID=VSP_027523;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TOM1L1	O75674	74	124	1	476	Chain	ID=PRO_0000072566;Note=TOM1-like protein 1
TOM1L1	O75674	166	201	1	476	Chain	ID=PRO_0000072566;Note=TOM1-like protein 1
TOM1L1	O75674	74	124	22	154	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
TOM1L1	O75674	166	201	200	288	Domain	Note=GAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00373
TOM1L1	O75674	166	201	171	171	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923U0
TOM1L1	O75674	74	124	1	77	Alternative sequence	ID=VSP_057424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1L1	O75674	74	124	108	108	Natural variant	ID=VAR_047469;Note=R->S;Dbxref=dbSNP:rs16955377
TOM1L1	O75674	74	124	66	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L1	O75674	74	124	85	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L1	O75674	74	124	94	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L1	O75674	74	124	98	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L1	O75674	74	124	102	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L1	O75674	74	124	107	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L1	O75674	74	124	113	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RRU
TOM1L2	Q6ZVM7	426	446	1	507	Chain	ID=PRO_0000278790;Note=TOM1-like protein 2
TOM1L2	Q6ZVM7	167	220	1	507	Chain	ID=PRO_0000278790;Note=TOM1-like protein 2
TOM1L2	Q6ZVM7	122	167	1	507	Chain	ID=PRO_0000278790;Note=TOM1-like protein 2
TOM1L2	Q6ZVM7	72	122	1	507	Chain	ID=PRO_0000278790;Note=TOM1-like protein 2
TOM1L2	Q6ZVM7	122	167	20	152	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
TOM1L2	Q6ZVM7	72	122	20	152	Domain	Note=VHS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00218
TOM1L2	Q6ZVM7	167	220	219	307	Domain	Note=GAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00373
TOM1L2	Q6ZVM7	122	167	160	160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TOM1L2	Q6ZVM7	122	167	164	164	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TOM1L2	Q6ZVM7	167	220	1	267	Alternative sequence	ID=VSP_023390;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1L2	Q6ZVM7	122	167	1	267	Alternative sequence	ID=VSP_023390;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1L2	Q6ZVM7	72	122	1	267	Alternative sequence	ID=VSP_023390;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1L2	Q6ZVM7	122	167	73	122	Alternative sequence	ID=VSP_023391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TOM1L2	Q6ZVM7	72	122	73	122	Alternative sequence	ID=VSP_023391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TOM1L2	Q6ZVM7	167	220	123	167	Alternative sequence	ID=VSP_023392;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11997338,ECO:0000303|PubMed:14702039;Dbxref=PMID:11997338,PMID:14702039
TOM1L2	Q6ZVM7	122	167	123	167	Alternative sequence	ID=VSP_023392;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11997338,ECO:0000303|PubMed:14702039;Dbxref=PMID:11997338,PMID:14702039
TOM1L2	Q6ZVM7	167	220	168	220	Alternative sequence	ID=VSP_057214;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1L2	Q6ZVM7	426	446	426	426	Alternative sequence	ID=VSP_057215;Note=In isoform 5. G->GTFLSSAQKRGRGGESDLEPIDSWLITQGM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOM1L2	Q6ZVM7	167	220	177	177	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM204	Q9BSN7	93	145	1	226	Chain	ID=PRO_0000089865;Note=Transmembrane protein 204
TMEM204	Q9BSN7	93	145	1	226	Chain	ID=PRO_0000089865;Note=Transmembrane protein 204
TMEM204	Q9BSN7	93	145	27	103	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	27	103	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	104	124	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	104	124	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	125	136	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	125	136	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM204	Q9BSN7	93	145	137	157	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN2	O15020	1730	1855	2	2390	Chain	ID=PRO_0000073463;Note=Spectrin beta chain%2C non-erythrocytic 2
SPTBN2	O15020	1730	1855	2	2390	Chain	ID=PRO_0000073463;Note=Spectrin beta chain%2C non-erythrocytic 2
SPTBN2	O15020	1730	1855	1696	1797	Repeat	Note=Spectrin 14;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN2	O15020	1730	1855	1696	1797	Repeat	Note=Spectrin 14;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN2	O15020	1730	1855	1801	1904	Repeat	Note=Spectrin 15;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPTBN2	O15020	1730	1855	1801	1904	Repeat	Note=Spectrin 15;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMLHE	Q9NVH6	253	331	16	421	Chain	ID=PRO_0000002795;Note=Trimethyllysine dioxygenase%2C mitochondrial
TMLHE	Q9NVH6	60	119	16	421	Chain	ID=PRO_0000002795;Note=Trimethyllysine dioxygenase%2C mitochondrial
TMLHE	Q9NVH6	60	119	1	68	Alternative sequence	ID=VSP_042275;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMLHE	Q9NVH6	60	119	61	120	Alternative sequence	ID=VSP_042277;Note=In isoform 6. ELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTW->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMLHE	Q9NVH6	60	119	66	66	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	206	227	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	157	181	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	130	141	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	118	130	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	100	118	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	70	100	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	24	70	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	206	227	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	157	181	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	130	141	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	118	130	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	100	118	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	70	100	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	24	70	1	233	Chain	ID=PRO_0000280358;Note=Transmembrane protein 40
TMEM40	Q8WWA1	157	181	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM40	Q8WWA1	157	181	160	180	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM40	Q8WWA1	206	227	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM40	Q8WWA1	206	227	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM40	Q8WWA1	70	100	50	72	Compositional bias	Note=Ser-rich
TMEM40	Q8WWA1	24	70	50	72	Compositional bias	Note=Ser-rich
TMEM40	Q8WWA1	70	100	50	72	Compositional bias	Note=Ser-rich
TMEM40	Q8WWA1	24	70	50	72	Compositional bias	Note=Ser-rich
TMEM40	Q8WWA1	130	141	137	137	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19367720;Dbxref=PMID:19367720
TMEM40	Q8WWA1	130	141	137	137	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19367720;Dbxref=PMID:19367720
TMEM40	Q8WWA1	100	118	25	101	Alternative sequence	ID=VSP_055682;Note=In isoform 3. YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	70	100	25	101	Alternative sequence	ID=VSP_055682;Note=In isoform 3. YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	24	70	25	101	Alternative sequence	ID=VSP_055682;Note=In isoform 3. YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	100	118	25	101	Alternative sequence	ID=VSP_055682;Note=In isoform 3. YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	70	100	25	101	Alternative sequence	ID=VSP_055682;Note=In isoform 3. YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	24	70	25	101	Alternative sequence	ID=VSP_055682;Note=In isoform 3. YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	100	118	71	100	Alternative sequence	ID=VSP_023643;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM40	Q8WWA1	70	100	71	100	Alternative sequence	ID=VSP_023643;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM40	Q8WWA1	100	118	71	100	Alternative sequence	ID=VSP_023643;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM40	Q8WWA1	70	100	71	100	Alternative sequence	ID=VSP_023643;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM40	Q8WWA1	24	70	55	55	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM40	Q8WWA1	24	70	55	55	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM54	Q969K7	153	198	1	222	Chain	ID=PRO_0000226989;Note=Transmembrane protein 54
TMEM54	Q969K7	90	153	1	222	Chain	ID=PRO_0000226989;Note=Transmembrane protein 54
TMEM54	Q969K7	70	90	1	222	Chain	ID=PRO_0000226989;Note=Transmembrane protein 54
TMEM54	Q969K7	70	90	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM54	Q969K7	90	153	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM54	Q969K7	153	198	155	175	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM54	Q969K7	90	153	71	123	Alternative sequence	ID=VSP_017533;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM54	Q969K7	70	90	71	123	Alternative sequence	ID=VSP_017533;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM54	Q969K7	90	153	71	90	Alternative sequence	ID=VSP_017532;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TMEM54	Q969K7	70	90	71	90	Alternative sequence	ID=VSP_017532;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TMEM54	Q969K7	90	153	110	110	Natural variant	ID=VAR_052342;Note=L->F;Dbxref=dbSNP:rs10914632
TMEM54	Q969K7	90	153	144	144	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM54	Q969K7	153	198	172	172	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRP54	P61011	385	442	1	504	Chain	ID=PRO_0000101192;Note=Signal recognition particle 54 kDa protein
SRP54	P61011	385	442	1	504	Chain	ID=PRO_0000101192;Note=Signal recognition particle 54 kDa protein
SRP54	P61011	385	442	296	504	Region	Note=M-domain
SRP54	P61011	385	442	296	504	Region	Note=M-domain
SRP54	P61011	385	442	384	388	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	384	388	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	390	392	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	390	392	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	393	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	393	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	401	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	401	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	414	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRP54	P61011	385	442	414	430	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QB2
SRPK2	P78362	596	627	1	688	Chain	ID=PRO_0000086677;Note=SRSF protein kinase 2
SRPK2	P78362	596	627	1	688	Chain	ID=PRO_0000086677;Note=SRSF protein kinase 2
SRPK2	P78362	596	627	140	688	Chain	ID=PRO_0000414752;Note=SRSF protein kinase 2 C-terminal
SRPK2	P78362	596	627	140	688	Chain	ID=PRO_0000414752;Note=SRSF protein kinase 2 C-terminal
SRPK2	P78362	596	627	81	684	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SRPK2	P78362	596	627	81	684	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SRPK2	P78362	596	627	608	608	Natural variant	ID=VAR_060390;Note=S->N;Dbxref=dbSNP:rs1050413
SRPK2	P78362	596	627	608	608	Natural variant	ID=VAR_060390;Note=S->N;Dbxref=dbSNP:rs1050413
SRPK2	P78362	596	627	615	615	Natural variant	ID=VAR_057111;Note=L->I;Dbxref=dbSNP:rs1050418
SRPK2	P78362	596	627	615	615	Natural variant	ID=VAR_057111;Note=L->I;Dbxref=dbSNP:rs1050418
SRPK2	P78362	596	627	601	601	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	601	601	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	608	609	Sequence conflict	Note=SI->KV;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	608	609	Sequence conflict	Note=SI->KV;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	612	616	Sequence conflict	Note=HFALS->KYAML;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	612	616	Sequence conflict	Note=HFALS->KYAML;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	621	621	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	621	621	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	625	627	Sequence conflict	Note=NRR->TRK;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	625	627	Sequence conflict	Note=NRR->TRK;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRPK2	P78362	596	627	594	606	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X7G
SRPK2	P78362	596	627	594	606	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X7G
SRPK2	P78362	596	627	611	614	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X7G
SRPK2	P78362	596	627	611	614	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X7G
SRPK2	P78362	596	627	620	623	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X7G
SRPK2	P78362	596	627	620	623	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2X7G
SRP68	Q9UHB9	326	359	1	627	Chain	ID=PRO_0000135227;Note=Signal recognition particle subunit SRP68
SRP68	Q9UHB9	84	121	1	627	Chain	ID=PRO_0000135227;Note=Signal recognition particle subunit SRP68
SRP68	Q9UHB9	326	359	1	339	Alternative sequence	ID=VSP_045132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SRP68	Q9UHB9	84	121	1	339	Alternative sequence	ID=VSP_045132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SRP68	Q9UHB9	84	121	84	121	Alternative sequence	ID=VSP_046944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SRP68	Q9UHB9	84	121	80	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P3F
SRP68	Q9UHB9	84	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P3F
SRP68	Q9UHB9	84	121	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P3F
SRRM4	A7MD48	427	463	1	611	Chain	ID=PRO_0000311911;Note=Serine/arginine repetitive matrix protein 4
SRRM4	A7MD48	427	463	123	608	Compositional bias	Note=Ser-rich
SRRM4	A7MD48	427	463	442	598	Compositional bias	Note=Arg-rich
TMOD1	P28289	132	162	1	359	Chain	ID=PRO_0000186128;Note=Tropomodulin-1
TMOD1	P28289	206	242	1	359	Chain	ID=PRO_0000186128;Note=Tropomodulin-1
TMOD1	P28289	132	162	1	359	Chain	ID=PRO_0000186128;Note=Tropomodulin-1
TMOD1	P28289	206	242	1	359	Chain	ID=PRO_0000186128;Note=Tropomodulin-1
TMOD1	P28289	132	162	39	138	Region	Note=Tropomyosin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMOD1	P28289	132	162	39	138	Region	Note=Tropomyosin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMOD1	P28289	132	162	7	133	Alternative sequence	ID=VSP_056864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMOD1	P28289	132	162	7	133	Alternative sequence	ID=VSP_056864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMOD1	P28289	206	242	210	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z8G
TMOD1	P28289	206	242	210	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z8G
TMOD1	P28289	206	242	228	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PKI
TMOD1	P28289	206	242	228	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PKI
TMOD1	P28289	206	242	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PKI
TMOD1	P28289	206	242	238	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PKI
SRSF3	P84103	69	113	1	164	Chain	ID=PRO_0000081923;Note=Serine/arginine-rich splicing factor 3
SRSF3	P84103	114	126	1	164	Chain	ID=PRO_0000081923;Note=Serine/arginine-rich splicing factor 3
SRSF3	P84103	127	155	1	164	Chain	ID=PRO_0000081923;Note=Serine/arginine-rich splicing factor 3
SRSF3	P84103	69	113	10	83	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SRSF3	P84103	114	126	119	133	Repeat	Note=B-1
SRSF3	P84103	127	155	119	133	Repeat	Note=B-1
SRSF3	P84103	127	155	149	164	Repeat	Note=B-2
SRSF3	P84103	69	113	1	90	Region	Note=Sufficient for interaction with NXF1
SRSF3	P84103	114	126	119	164	Region	Note=2 X approximate repeats%2C basic
SRSF3	P84103	127	155	119	164	Region	Note=2 X approximate repeats%2C basic
SRSF3	P84103	69	113	86	164	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF3	P84103	114	126	86	164	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF3	P84103	127	155	86	164	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF3	P84103	114	126	115	164	Alternative sequence	ID=VSP_056243;Note=In isoform 2. SPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK->VTIMSLLTTL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SRSF3	P84103	127	155	115	164	Alternative sequence	ID=VSP_056243;Note=In isoform 2. SPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK->VTIMSLLTTL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SRSF3	P84103	69	113	86	86	Mutagenesis	Note=Abolishes interaction with NXF1. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17036044;Dbxref=PMID:17036044
SRSF3	P84103	69	113	88	88	Mutagenesis	Note=Abolishes interaction with NXF1. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17036044;Dbxref=PMID:17036044
SRSF3	P84103	69	113	90	90	Mutagenesis	Note=Abolishes interaction with NXF1. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17036044;Dbxref=PMID:17036044
SRSF3	P84103	69	113	67	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I2Y
SRSF3	P84103	69	113	71	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I2Y
SRSF3	P84103	69	113	77	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I2Y
SSBP4	Q9BWG4	93	123	1	385	Chain	ID=PRO_0000123832;Note=Single-stranded DNA-binding protein 4
SSBP4	Q9BWG4	145	165	1	385	Chain	ID=PRO_0000123832;Note=Single-stranded DNA-binding protein 4
SSBP4	Q9BWG4	250	262	1	385	Chain	ID=PRO_0000123832;Note=Single-stranded DNA-binding protein 4
SSBP4	Q9BWG4	145	165	125	279	Compositional bias	Note=Pro-rich
SSBP4	Q9BWG4	250	262	125	279	Compositional bias	Note=Pro-rich
SSBP4	Q9BWG4	93	123	123	144	Alternative sequence	ID=VSP_054113;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMX2	Q9Y320	83	121	49	296	Chain	ID=PRO_0000315752;Note=Thioredoxin-related transmembrane protein 2
TMX2	Q9Y320	83	121	49	102	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMX2	Q9Y320	83	121	103	125	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMX2	Q9Y320	83	121	114	269	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TMX2	Q9Y320	83	121	84	122	Alternative sequence	ID=VSP_030696;Note=In isoform 2. ITVEQHIGNIFMFSKVANTILFFRLDIRMGLLYITLCIV->M;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMX2	Q9Y320	83	121	90	90	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMX3	Q96JJ7	104	130	25	454	Chain	ID=PRO_0000034185;Note=Protein disulfide-isomerase TMX3
TMX3	Q96JJ7	104	130	25	375	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMX3	Q96JJ7	104	130	25	128	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
SSH2	Q76I76	382	448	1	1423	Chain	ID=PRO_0000094843;Note=Protein phosphatase Slingshot homolog 2
SSH2	Q76I76	333	381	1	1423	Chain	ID=PRO_0000094843;Note=Protein phosphatase Slingshot homolog 2
SSH2	Q76I76	382	448	307	447	Domain	Note=Tyrosine-protein phosphatase
SSH2	Q76I76	333	381	307	447	Domain	Note=Tyrosine-protein phosphatase
SSH2	Q76I76	382	448	392	392	Active site	Note=Phosphocysteine intermediate;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10044,ECO:0000269|PubMed:17427953;Dbxref=PMID:17427953
SSH2	Q76I76	382	448	196	1423	Alternative sequence	ID=VSP_016323;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11832213,ECO:0000303|PubMed:15489334;Dbxref=PMID:11832213,PMID:15489334
SSH2	Q76I76	333	381	196	1423	Alternative sequence	ID=VSP_016323;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11832213,ECO:0000303|PubMed:15489334;Dbxref=PMID:11832213,PMID:15489334
SSH2	Q76I76	382	448	392	392	Mutagenesis	Note=Abrogates phosphatase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11832213;Dbxref=PMID:11832213
SSH2	Q76I76	333	381	334	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	333	381	342	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	333	381	352	356	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	333	381	368	370	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	382	448	371	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	333	381	371	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	382	448	387	391	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	382	448	393	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	382	448	398	411	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	382	448	415	425	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
SSH2	Q76I76	382	448	433	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NT2
TANGO6	Q9C0B7	497	555	1	1094	Chain	ID=PRO_0000305059;Note=Transport and Golgi organization protein 6 homolog
TANGO6	Q9C0B7	900	947	1	1094	Chain	ID=PRO_0000305059;Note=Transport and Golgi organization protein 6 homolog
TANGO6	Q9C0B7	998	1036	1	1094	Chain	ID=PRO_0000305059;Note=Transport and Golgi organization protein 6 homolog
TANGO6	Q9C0B7	900	947	873	909	Repeat	Note=HEAT 1
TNIP2	Q8NFZ5	219	302	1	429	Chain	ID=PRO_0000322583;Note=TNFAIP3-interacting protein 2
TNIP2	Q8NFZ5	219	302	289	347	Region	Note=Ubiquitin-binding domain (UBD)
TNIP2	Q8NFZ5	219	302	196	226	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNIP2	Q8NFZ5	219	302	255	340	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNIP2	Q8NFZ5	219	302	249	249	Natural variant	ID=VAR_067969;Note=Found in patients with gastrointestinal diffuse large cell lymphoma%3B impairs inhibitory activity on CARD11-induced NF-kappa-B activation. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs116129895,PMID:21266526
TNIP2	Q8NFZ5	219	302	255	255	Natural variant	ID=VAR_067970;Note=Found in patients with gastrointestinal diffuse large cell lymphoma%3B somatic mutation%3B impairs inhibitory activity on CARD11-induced NF-kappa-B activation and impairs interaction with TNFAIP3. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs116412781,PMID:21266526
TNIP2	Q8NFZ5	219	302	263	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H07
TNIP2	Q8NFZ5	219	302	276	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5H07
SSC5D	A1L4H1	17	120	17	1573	Chain	ID=PRO_0000332985;Note=Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
SSC5D	A1L4H1	120	158	17	1573	Chain	ID=PRO_0000332985;Note=Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
SSC5D	A1L4H1	462	568	17	1573	Chain	ID=PRO_0000332985;Note=Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
SSC5D	A1L4H1	872	928	17	1573	Chain	ID=PRO_0000332985;Note=Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
SSC5D	A1L4H1	928	982	17	1573	Chain	ID=PRO_0000332985;Note=Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
SSC5D	A1L4H1	17	120	20	120	Domain	Note=SRCR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	120	158	20	120	Domain	Note=SRCR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	462	568	467	568	Domain	Note=SRCR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	872	928	772	872	Domain	Note=SRCR 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	928	982	970	1488	Compositional bias	Note=Pro-rich
SSC5D	A1L4H1	17	120	45	109	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	17	120	58	119	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	17	120	89	99	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	462	568	492	557	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	462	568	505	567	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	462	568	537	547	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
SSC5D	A1L4H1	928	982	929	953	Alternative sequence	ID=VSP_040792;Note=In isoform 2. GSKDGYKLPWTWDTPSGRGLAEGTP->EPEAGAPRGDAPRSRTARVAAPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19535143;Dbxref=PMID:19535143
SSC5D	A1L4H1	928	982	954	1573	Alternative sequence	ID=VSP_040793;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19535143;Dbxref=PMID:19535143
SSC5D	A1L4H1	928	982	976	976	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRRM1	Q8IYB3	465	494	1	904	Chain	ID=PRO_0000076326;Note=Serine/arginine repetitive matrix protein 1
SRRM1	Q8IYB3	543	579	1	904	Chain	ID=PRO_0000076326;Note=Serine/arginine repetitive matrix protein 1
SRRM1	Q8IYB3	465	494	300	688	Region	Note=Necessary for speckles and matrix localization
SRRM1	Q8IYB3	543	579	300	688	Region	Note=Necessary for speckles and matrix localization
SRRM1	Q8IYB3	465	494	163	726	Compositional bias	Note=Arg-rich
SRRM1	Q8IYB3	543	579	163	726	Compositional bias	Note=Arg-rich
SRRM1	Q8IYB3	465	494	278	756	Compositional bias	Note=Ser-rich
SRRM1	Q8IYB3	543	579	278	756	Compositional bias	Note=Ser-rich
SRRM1	Q8IYB3	543	579	550	799	Compositional bias	Note=Pro-rich
SRRM1	Q8IYB3	465	494	465	465	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163
SRRM1	Q8IYB3	465	494	478	478	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:20068231;Dbxref=PMID:16964243,PMID:20068231
SRRM1	Q8IYB3	543	579	549	549	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
SRRM1	Q8IYB3	543	579	551	551	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
SRRM1	Q8IYB3	543	579	555	555	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SRRM1	Q8IYB3	543	579	560	560	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17081983,PMID:20068231,PMID:23186163,PMID:24275569
SRRM1	Q8IYB3	543	579	562	562	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17081983,PMID:20068231,PMID:23186163,PMID:24275569
SRRM1	Q8IYB3	543	579	572	572	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SRRM1	Q8IYB3	543	579	574	574	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SRRM1	Q8IYB3	465	494	472	472	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TMEM98	Q9Y2Y6	44	87	1	226	Chain	ID=PRO_0000251711;Note=Transmembrane protein 98
TMEM98	Q9Y2Y6	138	157	1	226	Chain	ID=PRO_0000251711;Note=Transmembrane protein 98
TMEM98	Q9Y2Y6	44	87	1	226	Chain	ID=PRO_0000251711;Note=Transmembrane protein 98
TMEM98	Q9Y2Y6	138	157	1	226	Chain	ID=PRO_0000251711;Note=Transmembrane protein 98
TMEM98	Q9Y2Y6	44	87	83	83	Natural variant	ID=VAR_051451;Note=W->R;Dbxref=dbSNP:rs35124349
TMEM98	Q9Y2Y6	44	87	83	83	Natural variant	ID=VAR_051451;Note=W->R;Dbxref=dbSNP:rs35124349
TMOD2	Q9NZR1	94	135	1	351	Chain	ID=PRO_0000186131;Note=Tropomodulin-2
TMOD2	Q9NZR1	208	244	1	351	Chain	ID=PRO_0000186131;Note=Tropomodulin-2
TMOD2	Q9NZR1	208	244	209	244	Alternative sequence	ID=VSP_041506;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SRR	Q9GZT4	173	198	1	340	Chain	ID=PRO_0000185650;Note=Serine racemase
SRR	Q9GZT4	173	198	157	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L6B
SRR	Q9GZT4	173	198	179	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L6B
SRR	Q9GZT4	173	198	185	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L6B
SRR	Q9GZT4	173	198	188	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L6B
SRSF4	Q08170	193	222	1	494	Chain	ID=PRO_0000081925;Note=Serine/arginine-rich splicing factor 4
SRSF4	Q08170	193	222	179	494	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF7	Q16629	209	220	1	238	Chain	ID=PRO_0000081932;Note=Serine/arginine-rich splicing factor 7
SRSF7	Q16629	154	190	1	238	Chain	ID=PRO_0000081932;Note=Serine/arginine-rich splicing factor 7
SRSF7	Q16629	154	190	153	160	Repeat	Note=1
SRSF7	Q16629	154	190	161	168	Repeat	Note=2
SRSF7	Q16629	154	190	169	176	Repeat	Note=3
SRSF7	Q16629	154	190	177	184	Repeat	Note=4
SRSF7	Q16629	209	220	211	218	Repeat	Note=5%3B approximate
SRSF7	Q16629	209	220	219	226	Repeat	Note=6%3B approximate
SRSF7	Q16629	209	220	153	226	Region	Note=6 X 8 AA repeats of R-R-S-R-S-X-S-X
SRSF7	Q16629	154	190	153	226	Region	Note=6 X 8 AA repeats of R-R-S-R-S-X-S-X
SRSF7	Q16629	209	220	121	238	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF7	Q16629	154	190	121	238	Compositional bias	Note=Arg/Ser-rich (RS domain)
SRSF7	Q16629	154	190	163	163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRSF7	Q16629	154	190	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRSF7	Q16629	154	190	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRSF7	Q16629	154	190	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BL97
SRSF7	Q16629	154	190	183	183	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BL97
SRSF7	Q16629	209	220	133	238	Alternative sequence	ID=VSP_005875;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRSF7	Q16629	154	190	133	238	Alternative sequence	ID=VSP_005875;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRSF7	Q16629	209	220	136	238	Alternative sequence	ID=VSP_005873;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRSF7	Q16629	154	190	136	238	Alternative sequence	ID=VSP_005873;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SRSF7	Q16629	209	220	209	220	Alternative sequence	ID=VSP_045840;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMPRSS9	Q7Z410	151	189	1	1059	Chain	ID=PRO_0000027867;Note=Transmembrane protease serine 9;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS9	Q7Z410	151	189	51	1059	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS9	Q7Z410	151	189	153	190	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
TMPRSS9	Q7Z410	151	189	154	166	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS9	Q7Z410	151	189	161	180	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS9	Q7Z410	151	189	174	189	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SSR4	P51571	62	87	24	173	Chain	ID=PRO_0000033292;Note=Translocon-associated protein subunit delta
SSR4	P51571	62	87	24	173	Chain	ID=PRO_0000033292;Note=Translocon-associated protein subunit delta
SSR4	P51571	62	87	24	173	Chain	ID=PRO_0000033292;Note=Translocon-associated protein subunit delta
SSR4	P51571	62	87	24	144	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSR4	P51571	62	87	24	144	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSR4	P51571	62	87	24	144	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSR4	P51571	62	87	73	73	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
SSR4	P51571	62	87	73	73	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
SSR4	P51571	62	87	73	73	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
SS18	Q15532	293	324	2	418	Chain	ID=PRO_0000181823;Note=Protein SSXT
SS18	Q15532	258	293	2	418	Chain	ID=PRO_0000181823;Note=Protein SSXT
SS18	Q15532	128	202	2	418	Chain	ID=PRO_0000181823;Note=Protein SSXT
SS18	Q15532	128	202	2	186	Region	Note=Transcriptional activation
SS18	Q15532	293	324	175	418	Compositional bias	Note=Gln-rich
SS18	Q15532	258	293	175	418	Compositional bias	Note=Gln-rich
SS18	Q15532	128	202	175	418	Compositional bias	Note=Gln-rich
SS18	Q15532	293	324	295	325	Alternative sequence	ID=VSP_006258;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7951320;Dbxref=PMID:7951320
STK32A	Q8WU08	220	259	2	396	Chain	ID=PRO_0000232411;Note=Serine/threonine-protein kinase 32A
STK32A	Q8WU08	220	259	23	281	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK32A	Q8WU08	220	259	167	396	Alternative sequence	ID=VSP_051993;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STK32A	Q8WU08	220	259	231	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FR4
STK32A	Q8WU08	220	259	251	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FR4
STK38L	Q9Y2H1	62	103	2	464	Chain	ID=PRO_0000086720;Note=Serine/threonine-protein kinase 38-like
STK38L	Q9Y2H1	360	391	2	464	Chain	ID=PRO_0000086720;Note=Serine/threonine-protein kinase 38-like
STK38L	Q9Y2H1	62	103	90	383	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK38L	Q9Y2H1	360	391	90	383	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK38L	Q9Y2H1	360	391	384	453	Domain	Note=AGC-kinase C-terminal
STK38L	Q9Y2H1	62	103	96	104	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:O95835,ECO:0000255|PROSITE-ProRule:PRU00159
STK38L	Q9Y2H1	62	103	63	88	Region	Note=S100B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
STK38L	Q9Y2H1	62	103	75	75	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037617;Dbxref=PMID:15037617
STK38L	Q9Y2H1	62	103	62	102	Alternative sequence	ID=VSP_056234;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STK38L	Q9Y2H1	62	103	99	99	Natural variant	ID=VAR_041199;Note=In a aLL TEL/AML1+ sample%3B somatic mutation. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
STK38L	Q9Y2H1	62	103	75	75	Mutagenesis	Note=Decreased kinase activity. Reduced binding of S100B. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15037617;Dbxref=PMID:15037617
ST18	O60284	602	684	1	1047	Chain	ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein
STAG3	Q9UJ98	73	112	1	1225	Chain	ID=PRO_0000120188;Note=Cohesin subunit SA-3
STAG3	Q9UJ98	900	934	1	1225	Chain	ID=PRO_0000120188;Note=Cohesin subunit SA-3
STAG3	Q9UJ98	1138	1171	1	1225	Chain	ID=PRO_0000120188;Note=Cohesin subunit SA-3
STAG3	Q9UJ98	73	112	1	1225	Chain	ID=PRO_0000120188;Note=Cohesin subunit SA-3
STAG3	Q9UJ98	900	934	1	1225	Chain	ID=PRO_0000120188;Note=Cohesin subunit SA-3
STAG3	Q9UJ98	1138	1171	1	1225	Chain	ID=PRO_0000120188;Note=Cohesin subunit SA-3
STAG3	Q9UJ98	900	934	759	1053	Alternative sequence	ID=VSP_006997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STAG3	Q9UJ98	900	934	759	1053	Alternative sequence	ID=VSP_006997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STAG3	Q9UJ98	1138	1171	1138	1138	Sequence conflict	Note=G->GS;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAG3	Q9UJ98	1138	1171	1138	1138	Sequence conflict	Note=G->GS;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK3	Q13188	274	316	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
STK3	Q13188	228	274	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
STK3	Q13188	36	78	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
STK3	Q13188	9	35	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
STK3	Q13188	274	316	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
STK3	Q13188	228	274	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
STK3	Q13188	36	78	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
STK3	Q13188	9	35	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
STK3	Q13188	274	316	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK3	Q13188	228	274	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK3	Q13188	36	78	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK3	Q13188	9	35	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK3	Q13188	36	78	33	41	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK3	Q13188	9	35	33	41	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK3	Q13188	274	316	287	328	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STK3	Q13188	274	316	308	314	Compositional bias	Note=Poly-Glu
STK3	Q13188	36	78	56	56	Binding site	Note=ATP
STK3	Q13188	9	35	15	15	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
STK3	Q13188	274	316	316	316	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:21406692,PMID:23186163
STK3	Q13188	36	78	60	60	Natural variant	ID=VAR_041122;Note=In an ovarian clear cell carcinoma sample%3B somatic mutation. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
STK3	Q13188	36	78	56	56	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16930133;Dbxref=PMID:16930133
STK3	Q13188	274	316	303	303	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
STK3	Q13188	9	35	17	20	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LGD
STK3	Q13188	9	35	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	9	35	27	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	36	78	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AO5
STK3	Q13188	36	78	40	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	36	78	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	36	78	52	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	36	78	64	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	228	274	226	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	228	274	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	228	274	249	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	228	274	263	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	228	274	269	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	274	316	276	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	274	316	284	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	274	316	288	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4
STK3	Q13188	274	316	308	311	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AO5
STRADB	Q9C0K7	4	31	1	418	Chain	ID=PRO_0000085617;Note=STE20-related kinase adapter protein beta
STRADB	Q9C0K7	4	31	1	138	Alternative sequence	ID=VSP_016625;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12048196,ECO:0000303|Ref.3;Dbxref=PMID:12048196
STX12	Q86Y82	96	142	2	276	Chain	ID=PRO_0000210223;Note=Syntaxin-12
STX12	Q86Y82	96	142	2	248	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
STX12	Q86Y82	96	142	33	131	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STX12	Q86Y82	96	142	139	139	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ER00
STX12	Q86Y82	96	142	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
STX12	Q86Y82	96	142	93	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNX
STT3A	P46977	320	372	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	403	455	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	518	557	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	591	654	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	320	372	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	403	455	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	518	557	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	591	654	1	705	Chain	ID=PRO_0000072290;Note=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
STT3A	P46977	320	372	301	321	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STT3A	P46977	320	372	301	321	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STT3A	P46977	320	372	322	356	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	320	372	322	356	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	320	372	357	379	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	320	372	357	379	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	403	455	403	406	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	403	406	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	407	428	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	403	455	407	428	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	403	455	429	453	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	429	453	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	454	473	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	403	455	454	473	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	518	557	474	705	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	591	654	474	705	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	518	557	474	705	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	591	654	474	705	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	518	557	525	527	Region	Note=Target acceptor peptide binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	518	557	525	527	Region	Note=Target acceptor peptide binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	320	372	348	351	Motif	Note=SVSE motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5HTX9
STT3A	P46977	320	372	348	351	Motif	Note=SVSE motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5HTX9
STT3A	P46977	518	557	525	529	Motif	Note=WWDYG motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	518	557	525	529	Motif	Note=WWDYG motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	591	654	592	599	Motif	Note=DK motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	591	654	592	599	Motif	Note=DK motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39007
STT3A	P46977	320	372	351	351	Binding site	Note=Target acceptor peptide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	320	372	351	351	Binding site	Note=Target acceptor peptide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	403	455	405	405	Binding site	Note=Lipid-linked oligosaccharide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	403	455	405	405	Binding site	Note=Lipid-linked oligosaccharide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	518	557	530	530	Binding site	Note=Lipid-linked oligosaccharide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	518	557	530	530	Binding site	Note=Lipid-linked oligosaccharide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	591	654	595	595	Binding site	Note=Target acceptor peptide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	591	654	595	595	Binding site	Note=Target acceptor peptide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9KDD4
STT3A	P46977	518	557	537	537	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STT3A	P46977	518	557	537	537	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STT3A	P46977	518	557	544	544	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STT3A	P46977	518	557	544	544	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STT3A	P46977	518	557	548	548	Glycosylation	Note=N-linked (GlcNAc...) (high mannose) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STT3A	P46977	518	557	548	548	Glycosylation	Note=N-linked (GlcNAc...) (high mannose) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STT3A	P46977	591	654	626	626	Natural variant	ID=VAR_070944;Note=In CDG1W%3B affects activity resulting in hypoglycosylation of STT3A-specific substrates. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23842455;Dbxref=dbSNP:rs587777216,PMID:23842455
STT3A	P46977	591	654	626	626	Natural variant	ID=VAR_070944;Note=In CDG1W%3B affects activity resulting in hypoglycosylation of STT3A-specific substrates. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23842455;Dbxref=dbSNP:rs587777216,PMID:23842455
STT3A	P46977	403	455	415	415	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	415	415	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	454	454	Sequence conflict	Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
STT3A	P46977	403	455	454	454	Sequence conflict	Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP3	O00186	270	301	1	592	Chain	ID=PRO_0000206285;Note=Syntaxin-binding protein 3
STXBP3	O00186	452	483	1	592	Chain	ID=PRO_0000206285;Note=Syntaxin-binding protein 3
STXBP3	O00186	270	301	295	295	Natural variant	ID=VAR_052470;Note=R->Q;Dbxref=dbSNP:rs2275344
STXBP3	O00186	270	301	277	277	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP3	O00186	270	301	285	285	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP4	Q6ZWJ1	315	337	1	553	Chain	ID=PRO_0000076330;Note=Syntaxin-binding protein 4
STXBP4	Q6ZWJ1	337	396	1	553	Chain	ID=PRO_0000076330;Note=Syntaxin-binding protein 4
STXBP4	Q6ZWJ1	315	337	291	417	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STXBP4	Q6ZWJ1	337	396	291	417	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
STXBP4	Q6ZWJ1	315	337	316	320	Alternative sequence	ID=VSP_017177;Note=In isoform 2. EKLLE->WPGQN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STXBP4	Q6ZWJ1	315	337	321	553	Alternative sequence	ID=VSP_017178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STXBP4	Q6ZWJ1	337	396	321	553	Alternative sequence	ID=VSP_017178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STXBP5	Q5T5C0	735	751	1	1151	Chain	ID=PRO_0000051244;Note=Syntaxin-binding protein 5
STXBP5	Q5T5C0	735	751	716	768	Alternative sequence	ID=VSP_016204;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
STXBP5	Q5T5C0	735	751	716	751	Alternative sequence	ID=VSP_016205;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SUCLG1	P53597	275	338	41	346	Chain	ID=PRO_0000033340;Note=Succinate--CoA ligase [ADP/GDP-forming] subunit alpha%2C mitochondrial
SUCLG1	P53597	196	224	41	346	Chain	ID=PRO_0000033340;Note=Succinate--CoA ligase [ADP/GDP-forming] subunit alpha%2C mitochondrial
SUCLG1	P53597	67	106	41	346	Chain	ID=PRO_0000033340;Note=Succinate--CoA ligase [ADP/GDP-forming] subunit alpha%2C mitochondrial
SUCLG1	P53597	67	106	64	67	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03222
SUCLG1	P53597	275	338	299	299	Active site	Note=Tele-phosphohistidine intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03222
SUCLG1	P53597	67	106	90	90	Binding site	Note=Coenzyme A;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03222
SUCLG1	P53597	196	224	207	207	Binding site	Note=Substrate%3B shared with subunit beta;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03222
SUCLG1	P53597	67	106	81	81	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUM5
SUCLG1	P53597	67	106	105	105	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUM5
SUCLG1	P53597	275	338	338	338	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUM5
SUCLG1	P53597	67	106	85	85	Natural variant	ID=VAR_065157;Note=In MTDPS9. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19526370;Dbxref=dbSNP:rs267607097,PMID:19526370
SUCLG1	P53597	67	106	87	87	Sequence conflict	Note=T->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUCLG1	P53597	67	106	66	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	67	106	81	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	67	106	98	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	67	106	104	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	196	224	193	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	196	224	204	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	196	224	220	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	275	338	282	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	275	338	311	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUCLG1	P53597	275	338	332	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6G4Q
SUFU	Q9UMX1	432	455	1	484	Chain	ID=PRO_0000072302;Note=Suppressor of fused homolog
SUFU	Q9UMX1	432	455	433	484	Alternative sequence	ID=VSP_013280;Note=In isoform 3. ILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH->VRRPFFFSLLPFIDFLAHPSSSPLAALDGTPSWGAGHECLMDSGPGACV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10564661;Dbxref=PMID:10564661
SUFU	Q9UMX1	432	455	433	433	Alternative sequence	ID=VSP_013278;Note=In isoform 2. I->L;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10564661,ECO:0000303|PubMed:12975309;Dbxref=PMID:10564661,PMID:12975309
SUFU	Q9UMX1	432	455	434	484	Alternative sequence	ID=VSP_013279;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10564661,ECO:0000303|PubMed:12975309;Dbxref=PMID:10564661,PMID:12975309
SUFU	Q9UMX1	432	455	299	484	Natural variant	ID=VAR_080424;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=PMID:28965847
SUFU	Q9UMX1	432	455	442	442	Natural variant	ID=VAR_080427;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs772598739,PMID:28965847
SUFU	Q9UMX1	432	455	430	434	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KMD
SUFU	Q9UMX1	432	455	437	446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KMD
SUFU	Q9UMX1	432	455	447	449	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KMD
TOP1MT	Q969P6	518	567	51	601	Chain	ID=PRO_0000034797;Note=DNA topoisomerase I%2C mitochondrial
TOP1MT	Q969P6	382	405	51	601	Chain	ID=PRO_0000034797;Note=DNA topoisomerase I%2C mitochondrial
TOP1MT	Q969P6	518	567	559	559	Active site	Note=O-(3'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10130
TOP1MT	Q969P6	518	567	525	525	Natural variant	ID=VAR_021863;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2293925,PMID:14702039
SUPV3L1	Q8IYB8	284	310	23	786	Chain	ID=PRO_0000310545;Note=ATP-dependent RNA helicase SUPV3L1%2C mitochondrial
SUPV3L1	Q8IYB8	506	533	23	786	Chain	ID=PRO_0000310545;Note=ATP-dependent RNA helicase SUPV3L1%2C mitochondrial
SUPV3L1	Q8IYB8	284	310	194	334	Domain	Note=Helicase ATP-binding
SUPV3L1	Q8IYB8	506	533	353	518	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SUPV3L1	Q8IYB8	284	310	285	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SUPV3L1	Q8IYB8	284	310	293	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SUPV3L1	Q8IYB8	284	310	299	301	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SUPV3L1	Q8IYB8	284	310	302	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SUPV3L1	Q8IYB8	506	533	508	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SUPV3L1	Q8IYB8	506	533	514	523	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SUPV3L1	Q8IYB8	506	533	529	539	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RC3
SFXN4	Q6P4A7	157	179	2	337	Chain	ID=PRO_0000177041;Note=Sideroflexin-4
SFXN4	Q6P4A7	37	59	2	337	Chain	ID=PRO_0000177041;Note=Sideroflexin-4
SFXN4	Q6P4A7	157	179	165	185	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFXN4	Q6P4A7	37	59	1	116	Alternative sequence	ID=VSP_014608;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SFXN5	Q8TD22	34	57	1	340	Chain	ID=PRO_0000177043;Note=Sideroflexin-5
SGCG	Q13326	128	168	1	291	Chain	ID=PRO_0000175248;Note=Gamma-sarcoglycan
SGCG	Q13326	128	168	59	291	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFXN1	Q9H9B4	275	290	2	322	Chain	ID=PRO_0000177032;Note=Sideroflexin-1
SFXN1	Q9H9B4	275	290	267	287	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SH2D3C	Q8N5H7	733	802	1	860	Chain	ID=PRO_0000228833;Note=SH2 domain-containing protein 3C
SH2D3C	Q8N5H7	733	802	586	854	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
SH2D3C	Q8N5H7	733	802	793	793	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QZS8
SH2D3C	Q8N5H7	733	802	738	740	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6G
SH2D3C	Q8N5H7	733	802	747	752	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6G
SH2D3C	Q8N5H7	733	802	773	787	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6G
SH2D3C	Q8N5H7	733	802	790	800	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6G
SH2D3C	Q8N5H7	733	802	801	803	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6G
SGTB	Q96EQ0	125	159	1	304	Chain	ID=PRO_0000106368;Note=Small glutamine-rich tetratricopeptide repeat-containing protein beta
SGTB	Q96EQ0	125	159	119	152	Repeat	Note=TPR 3
SGTB	Q96EQ0	125	159	153	186	Repeat	Note=TPR 4
SGTB	Q96EQ0	125	159	131	131	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43765
SHANK1	Q9Y566	85	153	1	2161	Chain	ID=PRO_0000174671;Note=SH3 and multiple ankyrin repeat domains protein 1
SHANK1	Q9Y566	85	153	1	613	Alternative sequence	ID=VSP_006069;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10551867;Dbxref=PMID:10551867
SH2D2A	Q9NP31	238	334	1	389	Chain	ID=PRO_0000097726;Note=SH2 domain-containing protein 2A
SH2D2A	Q9NP31	238	334	244	250	Motif	Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
SH2D2A	Q9NP31	238	334	272	278	Motif	Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
SH2D2A	Q9NP31	238	334	187	389	Compositional bias	Note=Pro-rich
SH2D2A	Q9NP31	238	334	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SH2D2A	Q9NP31	238	334	272	272	Natural variant	ID=VAR_056986;Note=R->C;Dbxref=dbSNP:rs12072861
SH2D4A	Q9H788	171	198	1	454	Chain	ID=PRO_0000233133;Note=SH2 domain-containing protein 4A
SH2D4A	Q9H788	171	198	1	454	Chain	ID=PRO_0000233133;Note=SH2 domain-containing protein 4A
SH2D4A	Q9H788	171	198	172	177	Compositional bias	Note=Poly-Ser
SH2D4A	Q9H788	171	198	172	177	Compositional bias	Note=Poly-Ser
SH2D4A	Q9H788	171	198	179	179	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH2D4A	Q9H788	171	198	179	179	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHQ1	Q6PI26	69	110	1	577	Chain	ID=PRO_0000302822;Note=Protein SHQ1 homolog
SHQ1	Q6PI26	69	110	1	89	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
SHQ1	Q6PI26	69	110	67	70	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBD
SHQ1	Q6PI26	69	110	71	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBD
SHQ1	Q6PI26	69	110	88	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PBD
SIPA1L2	Q9P2F8	1587	1605	1	1722	Chain	ID=PRO_0000056749;Note=Signal-induced proliferation-associated 1-like protein 2
SIPA1L2	Q9P2F8	1543	1587	1	1722	Chain	ID=PRO_0000056749;Note=Signal-induced proliferation-associated 1-like protein 2
SIPA1L2	Q9P2F8	1032	1117	1	1722	Chain	ID=PRO_0000056749;Note=Signal-induced proliferation-associated 1-like protein 2
SIPA1L2	Q9P2F8	1587	1605	1	1722	Chain	ID=PRO_0000056749;Note=Signal-induced proliferation-associated 1-like protein 2
SIPA1L2	Q9P2F8	1543	1587	1	1722	Chain	ID=PRO_0000056749;Note=Signal-induced proliferation-associated 1-like protein 2
SIPA1L2	Q9P2F8	1032	1117	1	1722	Chain	ID=PRO_0000056749;Note=Signal-induced proliferation-associated 1-like protein 2
SIPA1L2	Q9P2F8	1543	1587	1549	1549	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SIPA1L2	Q9P2F8	1543	1587	1549	1549	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SIPA1L2	Q9P2F8	1543	1587	1552	1552	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SIPA1L2	Q9P2F8	1543	1587	1552	1552	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SIPA1L2	Q9P2F8	1587	1605	1591	1591	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80TE4
SIPA1L2	Q9P2F8	1587	1605	1591	1591	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80TE4
SIPA1L2	Q9P2F8	1587	1605	1588	1605	Alternative sequence	ID=VSP_010922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SIPA1L2	Q9P2F8	1587	1605	1588	1605	Alternative sequence	ID=VSP_010922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ST6GALNAC3	Q8NDV1	208	243	1	305	Chain	ID=PRO_0000149275;Note=Alpha-N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 3
ST6GALNAC3	Q8NDV1	208	243	29	305	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC3	Q8NDV1	208	243	239	239	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC3	Q8NDV1	208	243	80	229	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST6GALNAC3	Q8NDV1	208	243	208	210	Alternative sequence	ID=VSP_013218;Note=In isoform 2. RVQ->STE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ST6GALNAC3	Q8NDV1	208	243	211	305	Alternative sequence	ID=VSP_013219;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ST6GALNAC3	Q8NDV1	208	243	223	223	Natural variant	ID=VAR_055846;Note=L->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1184626,PMID:15489334
ST6GALNAC4	Q9H4F1	204	239	1	302	Chain	ID=PRO_0000149278;Note=Alpha-N-acetyl-neuraminyl-2%2C3-beta-galactosyl-1%2C3-N-acetyl-galactosaminide alpha-2%2C6-sialyltransferase
ST6GALNAC4	Q9H4F1	4	66	1	302	Chain	ID=PRO_0000149278;Note=Alpha-N-acetyl-neuraminyl-2%2C3-beta-galactosyl-1%2C3-N-acetyl-galactosaminide alpha-2%2C6-sialyltransferase
ST6GALNAC4	Q9H4F1	4	66	1	6	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC4	Q9H4F1	4	66	7	27	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC4	Q9H4F1	204	239	28	302	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC4	Q9H4F1	4	66	28	302	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC4	Q9H4F1	204	239	76	225	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST6GALNAC5	Q9BVH7	224	259	1	336	Chain	ID=PRO_0000149280;Note=Alpha-N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 5
ST6GALNAC5	Q9BVH7	224	259	30	336	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC5	Q9BVH7	224	259	96	245	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SIDT1	Q9NXL6	221	249	20	827	Chain	ID=PRO_0000032575;Note=SID1 transmembrane family member 1
SIDT1	Q9NXL6	769	807	20	827	Chain	ID=PRO_0000032575;Note=SID1 transmembrane family member 1
SIDT1	Q9NXL6	221	249	20	309	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIDT1	Q9NXL6	769	807	763	791	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIDT1	Q9NXL6	769	807	792	812	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPG	Q9P1W8	249	360	29	387	Chain	ID=PRO_0000014957;Note=Signal-regulatory protein gamma
SIRPG	Q9P1W8	143	249	29	387	Chain	ID=PRO_0000014957;Note=Signal-regulatory protein gamma
SIRPG	Q9P1W8	249	360	29	360	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPG	Q9P1W8	143	249	29	360	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPG	Q9P1W8	143	249	146	245	Domain	Note=Ig-like C1-type 1
SIRPG	Q9P1W8	249	360	252	340	Domain	Note=Ig-like C1-type 2
SIRPG	Q9P1W8	143	249	243	243	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
SIRPG	Q9P1W8	249	360	268	268	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPG	Q9P1W8	249	360	309	309	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPG	Q9P1W8	249	360	317	317	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPG	Q9P1W8	143	249	168	226	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIRPG	Q9P1W8	249	360	271	329	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIRPG	Q9P1W8	249	360	144	360	Alternative sequence	ID=VSP_007028;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SIRPG	Q9P1W8	143	249	144	360	Alternative sequence	ID=VSP_007028;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SIRPG	Q9P1W8	249	360	250	360	Alternative sequence	ID=VSP_026960;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15383453;Dbxref=PMID:15383453
SIRPG	Q9P1W8	249	360	263	263	Natural variant	ID=VAR_049936;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11185750;Dbxref=dbSNP:rs6043409,PMID:11185750
SIRPG	Q9P1W8	249	360	286	286	Natural variant	ID=VAR_049937;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11185750;Dbxref=dbSNP:rs6034239,PMID:11185750
SIRPG	Q9P1W8	143	249	150	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	163	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	179	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	192	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	205	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	223	229	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	231	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	238	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	143	249	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	253	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	262	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	281	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	297	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	308	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	326	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SIRPG	Q9P1W8	249	360	339	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I2X
SKA3	Q8IX90	305	373	1	412	Chain	ID=PRO_0000089878;Note=Spindle and kinetochore-associated protein 3
SKA3	Q8IX90	305	373	318	318	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SKA3	Q8IX90	305	373	36	412	Alternative sequence	ID=VSP_040528;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SKA3	Q8IX90	305	373	335	335	Natural variant	ID=VAR_057832;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.1;Dbxref=dbSNP:rs17279819
SMARCA2	P51531	564	582	1	1590	Chain	ID=PRO_0000074352;Note=Probable global transcription activator SNF2L2
SMARCA2	P51531	1152	1228	1	1590	Chain	ID=PRO_0000074352;Note=Probable global transcription activator SNF2L2
SMARCA2	P51531	1400	1417	1	1590	Chain	ID=PRO_0000074352;Note=Probable global transcription activator SNF2L2
SMARCA2	P51531	564	582	1	1590	Chain	ID=PRO_0000074352;Note=Probable global transcription activator SNF2L2
SMARCA2	P51531	1152	1228	1	1590	Chain	ID=PRO_0000074352;Note=Probable global transcription activator SNF2L2
SMARCA2	P51531	1400	1417	1	1590	Chain	ID=PRO_0000074352;Note=Probable global transcription activator SNF2L2
SMARCA2	P51531	1152	1228	1054	1216	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SMARCA2	P51531	1152	1228	1054	1216	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SMARCA2	P51531	1400	1417	1400	1417	Alternative sequence	ID=VSP_000577;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8208605;Dbxref=PMID:8208605
SMARCA2	P51531	1400	1417	1400	1417	Alternative sequence	ID=VSP_000577;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8208605;Dbxref=PMID:8208605
SMARCA2	P51531	1152	1228	1158	1158	Natural variant	ID=VAR_068199;Note=In NCBRS. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875240,PMID:22366787
SMARCA2	P51531	1152	1228	1158	1158	Natural variant	ID=VAR_068199;Note=In NCBRS. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875240,PMID:22366787
SMARCA2	P51531	1152	1228	1159	1159	Natural variant	ID=VAR_068200;Note=In NCBRS. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875184,PMID:22366787
SMARCA2	P51531	1152	1228	1159	1159	Natural variant	ID=VAR_068200;Note=In NCBRS. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875184,PMID:22366787
SMARCA2	P51531	1152	1228	1159	1159	Natural variant	ID=VAR_068201;Note=In NCBRS. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875187,PMID:22366787
SMARCA2	P51531	1152	1228	1159	1159	Natural variant	ID=VAR_068201;Note=In NCBRS. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875187,PMID:22366787
SMARCA2	P51531	1152	1228	1159	1159	Natural variant	ID=VAR_068202;Note=In NCBRS. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875187,PMID:22366787
SMARCA2	P51531	1152	1228	1159	1159	Natural variant	ID=VAR_068202;Note=In NCBRS. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875187,PMID:22366787
SMARCA2	P51531	1152	1228	1162	1162	Natural variant	ID=VAR_068203;Note=In NCBRS. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875186,PMID:22366787
SMARCA2	P51531	1152	1228	1162	1162	Natural variant	ID=VAR_068203;Note=In NCBRS. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875186,PMID:22366787
SMARCA2	P51531	1152	1228	1188	1188	Natural variant	ID=VAR_068204;Note=In NCBRS. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875196,PMID:22366787
SMARCA2	P51531	1152	1228	1188	1188	Natural variant	ID=VAR_068204;Note=In NCBRS. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875196,PMID:22366787
SMARCA2	P51531	1152	1228	1201	1201	Natural variant	ID=VAR_068205;Note=In NCBRS. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875189,PMID:22366787
SMARCA2	P51531	1152	1228	1201	1201	Natural variant	ID=VAR_068205;Note=In NCBRS. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875189,PMID:22366787
SMARCA2	P51531	1152	1228	1202	1202	Natural variant	ID=VAR_068206;Note=In NCBRS. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875239,PMID:22366787
SMARCA2	P51531	1152	1228	1202	1202	Natural variant	ID=VAR_068206;Note=In NCBRS. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875239,PMID:22366787
SMARCA2	P51531	1152	1228	1205	1205	Natural variant	ID=VAR_068207;Note=In NCBRS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875201,PMID:22366787
SMARCA2	P51531	1152	1228	1205	1205	Natural variant	ID=VAR_068207;Note=In NCBRS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875201,PMID:22366787
SMARCA2	P51531	1152	1228	1213	1213	Natural variant	ID=VAR_068208;Note=In NCBRS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875238,PMID:22366787
SMARCA2	P51531	1152	1228	1213	1213	Natural variant	ID=VAR_068208;Note=In NCBRS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22366787;Dbxref=dbSNP:rs281875238,PMID:22366787
SMARCA2	P51531	1400	1417	1416	1416	Natural variant	ID=VAR_049501;Note=G->A;Dbxref=dbSNP:rs3793510
SMARCA2	P51531	1400	1417	1416	1416	Natural variant	ID=VAR_049501;Note=G->A;Dbxref=dbSNP:rs3793510
SMARCA2	P51531	1400	1417	1400	1400	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCA2	P51531	1400	1417	1400	1400	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRPD2	P62316	1	60	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:22814378,ECO:0000244|PubMed:25944712,ECO:0000269|Ref.6;Dbxref=PMID:22814378,PMID:25944712
SNRPD2	P62316	1	60	2	118	Chain	ID=PRO_0000122207;Note=Small nuclear ribonucleoprotein Sm D2
SNRPD2	P62316	1	60	2	2	Modified residue	Note=N-acetylserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:22814378,ECO:0000244|PubMed:25944712,ECO:0000269|Ref.6;Dbxref=PMID:22814378,PMID:25944712
SNRPD2	P62316	1	60	9	9	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SNRPD2	P62316	1	60	12	12	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SNRPD2	P62316	1	60	6	6	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SNRPD2	P62316	1	60	8	8	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SNRPD2	P62316	1	60	1	10	Alternative sequence	ID=VSP_045371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNRPD2	P62316	1	60	38	38	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRPD2	P62316	1	60	23	25	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XJL
SNRPD2	P62316	1	60	28	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD2	P62316	1	60	41	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD2	P62316	1	60	51	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SMARCE1	Q969G3	17	52	1	411	Chain	ID=PRO_0000048577;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
SMARCE1	Q969G3	17	52	5	65	Compositional bias	Note=Pro-rich
SMARCE1	Q969G3	17	52	40	40	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SMARCE1	Q969G3	17	52	1	70	Alternative sequence	ID=VSP_047604;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SMARCE1	Q969G3	17	52	17	51	Alternative sequence	ID=VSP_047825;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SMARCE1	Q969G3	17	52	46	46	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCE1	Q969G3	17	52	46	46	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCE1	Q969G3	17	52	46	46	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	121	170	1	343	Chain	ID=PRO_0000340699;Note=Single-pass membrane and coiled-coil domain-containing protein 2
SMCO2	A6NFE2	200	219	1	343	Chain	ID=PRO_0000340699;Note=Single-pass membrane and coiled-coil domain-containing protein 2
SMCO2	A6NFE2	121	170	1	343	Chain	ID=PRO_0000340699;Note=Single-pass membrane and coiled-coil domain-containing protein 2
SMCO2	A6NFE2	200	219	1	343	Chain	ID=PRO_0000340699;Note=Single-pass membrane and coiled-coil domain-containing protein 2
SMCO2	A6NFE2	121	170	152	238	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMCO2	A6NFE2	200	219	152	238	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMCO2	A6NFE2	121	170	152	238	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMCO2	A6NFE2	200	219	152	238	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMCO2	A6NFE2	121	170	129	129	Sequence conflict	Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	121	170	129	129	Sequence conflict	Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	121	170	165	165	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	121	170	165	165	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	200	219	212	212	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	200	219	212	212	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	200	219	216	216	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMCO2	A6NFE2	200	219	216	216	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX25	Q9H3E2	284	328	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	419	474	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	474	518	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	565	603	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	603	658	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	284	328	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	419	474	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	474	518	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	565	603	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	603	658	1	840	Chain	ID=PRO_0000213875;Note=Sorting nexin-25
SNX25	Q9H3E2	284	328	287	401	Domain	Note=RGS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
SNX25	Q9H3E2	284	328	287	401	Domain	Note=RGS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
SNX25	Q9H3E2	474	518	508	628	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX25	Q9H3E2	565	603	508	628	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX25	Q9H3E2	603	658	508	628	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX25	Q9H3E2	474	518	508	628	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX25	Q9H3E2	565	603	508	628	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX25	Q9H3E2	603	658	508	628	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX25	Q9H3E2	419	474	434	499	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SNX25	Q9H3E2	474	518	434	499	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SNX25	Q9H3E2	419	474	434	499	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SNX25	Q9H3E2	474	518	434	499	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SNX25	Q9H3E2	603	658	604	658	Alternative sequence	ID=VSP_057157;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNX25	Q9H3E2	603	658	604	658	Alternative sequence	ID=VSP_057157;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNX25	Q9H3E2	284	328	318	318	Natural variant	ID=VAR_047057;Note=E->K;Dbxref=dbSNP:rs35700132
SNX25	Q9H3E2	284	328	318	318	Natural variant	ID=VAR_047057;Note=E->K;Dbxref=dbSNP:rs35700132
SNX25	Q9H3E2	565	603	586	586	Natural variant	ID=VAR_047058;Note=I->V;Dbxref=dbSNP:rs3756275
SNX25	Q9H3E2	565	603	586	586	Natural variant	ID=VAR_047058;Note=I->V;Dbxref=dbSNP:rs3756275
SH3RF3	Q8TEJ3	191	283	1	882	Chain	ID=PRO_0000284883;Note=E3 ubiquitin-protein ligase SH3RF3
SH3RF3	Q8TEJ3	283	315	1	882	Chain	ID=PRO_0000284883;Note=E3 ubiquitin-protein ligase SH3RF3
SH3RF3	Q8TEJ3	315	433	1	882	Chain	ID=PRO_0000284883;Note=E3 ubiquitin-protein ligase SH3RF3
SH3RF3	Q8TEJ3	191	283	194	253	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF3	Q8TEJ3	191	283	256	319	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF3	Q8TEJ3	283	315	256	319	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF3	Q8TEJ3	315	433	256	319	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF3	Q8TEJ3	315	433	369	439	Region	Note=Interaction with RAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164
SH3RF3	Q8TEJ3	315	433	400	400	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18220336;Dbxref=PMID:18220336
SH3RF3	Q8TEJ3	315	433	403	403	Mutagenesis	Note=Significant loss of interaction with RAC1%3B alone or when associated with P-404 and A-406. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164
SH3RF3	Q8TEJ3	315	433	404	404	Mutagenesis	Note=Reduced JNK activation. Significant loss of interaction with RAC1%3B alone or when associated with N-403 and A-406. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164
SH3RF3	Q8TEJ3	315	433	406	406	Mutagenesis	Note=Significant loss of interaction with RAC1%3B when associated with N-403 and P-404. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164
SHROOM4	Q9ULL8	90	134	1	1493	Chain	ID=PRO_0000287077;Note=Protein Shroom4
SHROOM4	Q9ULL8	90	134	1	1493	Chain	ID=PRO_0000287077;Note=Protein Shroom4
SHROOM4	Q9ULL8	90	134	10	92	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SHROOM4	Q9ULL8	90	134	10	92	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SHROOM4	Q9ULL8	90	134	1	116	Alternative sequence	ID=VSP_025290;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SHROOM4	Q9ULL8	90	134	1	116	Alternative sequence	ID=VSP_025290;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SHROOM4	Q9ULL8	90	134	85	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDP
SHROOM4	Q9ULL8	90	134	85	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDP
SH3GLB2	Q9NR46	187	208	1	395	Chain	ID=PRO_0000146755;Note=Endophilin-B2
SH3GLB2	Q9NR46	156	187	1	395	Chain	ID=PRO_0000146755;Note=Endophilin-B2
SH3GLB2	Q9NR46	68	111	1	395	Chain	ID=PRO_0000146755;Note=Endophilin-B2
SH3GLB2	Q9NR46	187	208	1	395	Chain	ID=PRO_0000146755;Note=Endophilin-B2
SH3GLB2	Q9NR46	156	187	1	395	Chain	ID=PRO_0000146755;Note=Endophilin-B2
SH3GLB2	Q9NR46	68	111	1	395	Chain	ID=PRO_0000146755;Note=Endophilin-B2
SH3GLB2	Q9NR46	187	208	24	287	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB2	Q9NR46	156	187	24	287	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB2	Q9NR46	68	111	24	287	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB2	Q9NR46	187	208	24	287	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB2	Q9NR46	156	187	24	287	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB2	Q9NR46	68	111	24	287	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB2	Q9NR46	187	208	206	240	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SH3GLB2	Q9NR46	187	208	206	240	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SH3GLB2	Q9NR46	187	208	187	187	Alternative sequence	ID=VSP_009278;Note=In isoform 2. T->TCEGD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
SH3GLB2	Q9NR46	156	187	187	187	Alternative sequence	ID=VSP_009278;Note=In isoform 2. T->TCEGD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
SH3GLB2	Q9NR46	187	208	187	187	Alternative sequence	ID=VSP_009278;Note=In isoform 2. T->TCEGD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
SH3GLB2	Q9NR46	156	187	187	187	Alternative sequence	ID=VSP_009278;Note=In isoform 2. T->TCEGD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
SIGLEC6	O43699	235	251	27	453	Chain	ID=PRO_0000014946;Note=Sialic acid-binding Ig-like lectin 6
SIGLEC6	O43699	235	251	27	347	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC6	O43699	235	251	238	333	Domain	Note=Ig-like C2-type 2
SIGLEC6	O43699	235	251	236	252	Alternative sequence	ID=VSP_035812;Note=In isoform 3 and isoform 6. YAPQKVAISIFQGNSAA->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SIGLEC6	O43699	235	251	236	236	Alternative sequence	ID=VSP_045387;Note=In isoform 5. Y->WMLRRPPLSTPD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SIPA1	Q96FS4	769	841	1	1042	Chain	ID=PRO_0000056744;Note=Signal-induced proliferation-associated protein 1
SIPA1	Q96FS4	915	949	1	1042	Chain	ID=PRO_0000056744;Note=Signal-induced proliferation-associated protein 1
SIPA1	Q96FS4	769	841	1	1042	Chain	ID=PRO_0000056744;Note=Signal-induced proliferation-associated protein 1
SIPA1	Q96FS4	915	949	1	1042	Chain	ID=PRO_0000056744;Note=Signal-induced proliferation-associated protein 1
SIPA1	Q96FS4	769	841	817	817	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SIPA1	Q96FS4	769	841	817	817	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SIPA1	Q96FS4	769	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SIPA1	Q96FS4	769	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SIPA1	Q96FS4	769	841	781	782	Sequence conflict	Note=EP->DA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIPA1	Q96FS4	769	841	781	782	Sequence conflict	Note=EP->DA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIPA1	Q96FS4	769	841	796	796	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIPA1	Q96FS4	769	841	796	796	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX17	Q15036	227	258	1	470	Chain	ID=PRO_0000213865;Note=Sorting nexin-17
SNX17	Q15036	394	419	1	470	Chain	ID=PRO_0000213865;Note=Sorting nexin-17
SNX17	Q15036	227	258	115	432	Region	Note=FERM-like
SNX17	Q15036	394	419	115	432	Region	Note=FERM-like
SNX17	Q15036	394	419	270	432	Region	Note=PTB-like F3 module
SNX17	Q15036	394	419	407	407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SNX17	Q15036	394	419	409	409	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SNX17	Q15036	394	419	415	415	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
SNX17	Q15036	227	258	218	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GXB
SNX17	Q15036	227	258	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GXB
SNX17	Q15036	227	258	241	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GXB
SNX17	Q15036	227	258	256	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GXB
SPAG6	O75602	226	284	1	509	Chain	ID=PRO_0000072095;Note=Sperm-associated antigen 6
SPAG6	O75602	226	284	199	238	Repeat	Note=ARM 5
SPAG6	O75602	226	284	241	280	Repeat	Note=ARM 6
SPAG6	O75602	226	284	97	335	Alternative sequence	ID=VSP_013443;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT5A	P42229	95	125	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	278	329	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	460	491	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	705	740	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	95	125	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	278	329	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	460	491	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	705	740	1	794	Chain	ID=PRO_0000182423;Note=Signal transducer and activator of transcription 5A
STAT5A	P42229	95	125	96	125	Alternative sequence	ID=VSP_053332;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
STAT5A	P42229	95	125	96	125	Alternative sequence	ID=VSP_053332;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
STARD9	Q9P2P6	117	128	1	4700	Chain	ID=PRO_0000220678;Note=StAR-related lipid transfer protein 9
STARD9	Q9P2P6	289	359	1	4700	Chain	ID=PRO_0000220678;Note=StAR-related lipid transfer protein 9
STARD9	Q9P2P6	392	418	1	4700	Chain	ID=PRO_0000220678;Note=StAR-related lipid transfer protein 9
STARD9	Q9P2P6	418	439	1	4700	Chain	ID=PRO_0000220678;Note=StAR-related lipid transfer protein 9
STARD9	Q9P2P6	516	562	1	4700	Chain	ID=PRO_0000220678;Note=StAR-related lipid transfer protein 9
STARD9	Q9P2P6	117	128	3	384	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
STARD9	Q9P2P6	289	359	3	384	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
STARD9	Q9P2P6	516	562	498	569	Domain	Note=FHA
STARD9	Q9P2P6	289	359	290	292	Alternative sequence	ID=VSP_029574;Note=In isoform 2. AQN->GIF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STARD9	Q9P2P6	289	359	293	4700	Alternative sequence	ID=VSP_029575;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STARD9	Q9P2P6	392	418	293	4700	Alternative sequence	ID=VSP_029575;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STARD9	Q9P2P6	418	439	293	4700	Alternative sequence	ID=VSP_029575;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STARD9	Q9P2P6	516	562	293	4700	Alternative sequence	ID=VSP_029575;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
STARD9	Q9P2P6	392	418	360	435	Alternative sequence	ID=VSP_029576;Note=In isoform 3. TVSPAHTSYSETMSTLRYASSAKNIINKPRVNEDANLKLIRELREEIERLKALLLSFELRNFSSLSDENLKELVLQ->SEWDARAGPVLGLVLYLRERAMAPVSGMPELDLCWDWYSISEKGPWPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD9	Q9P2P6	418	439	360	435	Alternative sequence	ID=VSP_029576;Note=In isoform 3. TVSPAHTSYSETMSTLRYASSAKNIINKPRVNEDANLKLIRELREEIERLKALLLSFELRNFSSLSDENLKELVLQ->SEWDARAGPVLGLVLYLRERAMAPVSGMPELDLCWDWYSISEKGPWPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD9	Q9P2P6	418	439	436	4700	Alternative sequence	ID=VSP_029577;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD9	Q9P2P6	516	562	436	4700	Alternative sequence	ID=VSP_029577;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ST14	Q9Y5Y6	451	486	1	855	Chain	ID=PRO_0000088712;Note=Suppressor of tumorigenicity 14 protein
ST14	Q9Y5Y6	523	561	1	855	Chain	ID=PRO_0000088712;Note=Suppressor of tumorigenicity 14 protein
ST14	Q9Y5Y6	561	602	1	855	Chain	ID=PRO_0000088712;Note=Suppressor of tumorigenicity 14 protein
ST14	Q9Y5Y6	451	486	77	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST14	Q9Y5Y6	523	561	77	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST14	Q9Y5Y6	561	602	77	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST14	Q9Y5Y6	451	486	452	487	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
ST14	Q9Y5Y6	523	561	487	524	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
ST14	Q9Y5Y6	523	561	524	560	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
ST14	Q9Y5Y6	561	602	566	603	Domain	Note=LDL-receptor class A 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
ST14	Q9Y5Y6	451	486	485	485	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST14	Q9Y5Y6	451	486	453	464	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	451	486	459	477	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	451	486	471	486	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	523	561	508	523	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	523	561	525	537	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	523	561	532	550	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	523	561	544	559	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	561	602	567	579	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	561	602	574	593	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST14	Q9Y5Y6	561	602	587	602	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
STAT5B	P51692	635	692	1	787	Chain	ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B
STAT5B	P51692	460	491	1	787	Chain	ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B
STAT5B	P51692	278	329	1	787	Chain	ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B
STAT5B	P51692	95	125	1	787	Chain	ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B
STAT5B	P51692	635	692	589	686	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT5B	P51692	278	329	232	321	Region	Note=Required for interaction with NMI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9989503;Dbxref=PMID:9989503
STAT5B	P51692	635	692	682	682	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42229
STAT5B	P51692	635	692	646	646	Natural variant	ID=VAR_067368;Note=In GHII%3B transcriptionally inactive. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22419735;Dbxref=PMID:22419735
STAT5B	P51692	635	692	684	684	Mutagenesis	Note=Abolishes interaction with INSR. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9428692;Dbxref=PMID:9428692
STEAP4	Q687X5	152	328	1	459	Chain	ID=PRO_0000285174;Note=Metalloreductase STEAP4
STEAP4	Q687X5	152	328	196	216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP4	Q687X5	152	328	246	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP4	Q687X5	152	328	293	313	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP4	Q687X5	152	328	247	395	Domain	Note=Ferric oxidoreductase;Ontology_term=ECO:0000255;evidence=ECO:0000255
STEAP4	Q687X5	152	328	304	304	Metal binding	Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32791
STEAP4	Q687X5	152	328	171	171	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4V8K1
STEAP4	Q687X5	152	328	323	323	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
STEAP4	Q687X5	152	328	153	328	Alternative sequence	ID=VSP_024833;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
STARD3	Q14849	73	99	1	445	Chain	ID=PRO_0000220653;Note=StAR-related lipid transfer protein 3
STARD3	Q14849	125	143	1	445	Chain	ID=PRO_0000220653;Note=StAR-related lipid transfer protein 3
STARD3	Q14849	182	215	1	445	Chain	ID=PRO_0000220653;Note=StAR-related lipid transfer protein 3
STARD3	Q14849	73	99	73	94	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STARD3	Q14849	73	99	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3	Q14849	125	143	121	141	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3	Q14849	125	143	142	148	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STARD3	Q14849	182	215	170	445	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11053434;Dbxref=PMID:11053434
STARD3	Q14849	73	99	46	217	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3	Q14849	125	143	46	217	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3	Q14849	182	215	46	217	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3	Q14849	182	215	207	212	Motif	Note=FFAT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24105263;Dbxref=PMID:24105263
STARD3	Q14849	182	215	209	209	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61542
STARD3	Q14849	125	143	122	183	Alternative sequence	ID=VSP_045361;Note=In isoform 3. WVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERW->SRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRKLKRSDSAPPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD3	Q14849	182	215	122	183	Alternative sequence	ID=VSP_045361;Note=In isoform 3. WVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERW->SRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRKLKRSDSAPPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD3	Q14849	125	143	126	143	Alternative sequence	ID=VSP_042710;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD3	Q14849	73	99	89	89	Mutagenesis	Note=Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. Y->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11053434;Dbxref=PMID:11053434
STARD3	Q14849	182	215	206	212	Mutagenesis	Note=Abolishes interaction with VAPA and VAPB%2C thereby preventing contact with the endoplasmic reticulum membrane. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24105263;Dbxref=PMID:24105263
STARD3	Q14849	182	215	207	208	Mutagenesis	Note=Abolishes interaction with VAPA and VAPB%2C thereby preventing contact with the endoplasmic reticulum membrane. Abolishes cholesterol accumulation in endosomes. FY->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28377464;Dbxref=PMID:28377464
STK31	Q9BXU1	920	943	1	1019	Chain	ID=PRO_0000086715;Note=Serine/threonine-protein kinase 31
STK31	Q9BXU1	920	943	710	1019	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
STK31	Q9BXU1	920	943	921	943	Alternative sequence	ID=VSP_045210;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
STARD3NL	O95772	127	145	1	234	Chain	ID=PRO_0000021666;Note=STARD3 N-terminal-like protein
STARD3NL	O95772	184	216	1	234	Chain	ID=PRO_0000021666;Note=STARD3 N-terminal-like protein
STARD3NL	O95772	127	145	1	234	Chain	ID=PRO_0000021666;Note=STARD3 N-terminal-like protein
STARD3NL	O95772	184	216	1	234	Chain	ID=PRO_0000021666;Note=STARD3 N-terminal-like protein
STARD3NL	O95772	127	145	123	143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3NL	O95772	127	145	123	143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3NL	O95772	127	145	144	150	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STARD3NL	O95772	127	145	144	150	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
STARD3NL	O95772	184	216	172	234	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12393907;Dbxref=PMID:12393907
STARD3NL	O95772	184	216	172	234	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12393907;Dbxref=PMID:12393907
STARD3NL	O95772	127	145	48	218	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3NL	O95772	184	216	48	218	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3NL	O95772	127	145	48	218	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3NL	O95772	184	216	48	218	Domain	Note=MENTAL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00770
STARD3NL	O95772	184	216	208	213	Motif	Note=FFAT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24105263;Dbxref=PMID:24105263
STARD3NL	O95772	184	216	208	213	Motif	Note=FFAT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24105263;Dbxref=PMID:24105263
STARD3NL	O95772	184	216	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:23186163,PMID:24275569
STARD3NL	O95772	184	216	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:23186163,PMID:24275569
TOMM40	O96008	145	179	1	361	Chain	ID=PRO_0000051523;Note=Mitochondrial import receptor subunit TOM40 homolog
TOMM40	O96008	214	255	1	361	Chain	ID=PRO_0000051523;Note=Mitochondrial import receptor subunit TOM40 homolog
TOMM40	O96008	145	179	1	361	Chain	ID=PRO_0000051523;Note=Mitochondrial import receptor subunit TOM40 homolog
TOMM40	O96008	214	255	1	361	Chain	ID=PRO_0000051523;Note=Mitochondrial import receptor subunit TOM40 homolog
TOMM40	O96008	145	179	1	361	Chain	ID=PRO_0000051523;Note=Mitochondrial import receptor subunit TOM40 homolog
TOMM40	O96008	214	255	1	361	Chain	ID=PRO_0000051523;Note=Mitochondrial import receptor subunit TOM40 homolog
TOMM40	O96008	214	255	219	219	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TOMM40	O96008	214	255	219	219	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TOMM40	O96008	214	255	219	219	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TOMM40	O96008	214	255	220	220	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TOMM40	O96008	214	255	220	220	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TOMM40	O96008	214	255	220	220	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SULF1	Q8IWU6	57	137	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	354	396	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	397	415	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	57	137	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	354	396	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	397	415	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	57	137	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	354	396	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	397	415	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	57	137	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	354	396	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	397	415	23	871	Chain	ID=PRO_0000033434;Note=Extracellular sulfatase Sulf-1
SULF1	Q8IWU6	57	137	87	87	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Metal binding	Note=Calcium%3B via 3-oxoalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SULF1	Q8IWU6	57	137	87	87	Metal binding	Note=Calcium%3B via 3-oxoalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SULF1	Q8IWU6	57	137	87	87	Metal binding	Note=Calcium%3B via 3-oxoalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SULF1	Q8IWU6	57	137	87	87	Metal binding	Note=Calcium%3B via 3-oxoalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SULF1	Q8IWU6	57	137	87	87	Modified residue	Note=3-oxoalanine (Cys);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Modified residue	Note=3-oxoalanine (Cys);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Modified residue	Note=3-oxoalanine (Cys);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	87	87	Modified residue	Note=3-oxoalanine (Cys);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF1	Q8IWU6	57	137	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF1	Q8IWU6	57	137	87	88	Mutagenesis	Note=Loss of arylsulfatase activity and loss of ability to modulate apoptosis. CC->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12368295,ECO:0000269|PubMed:12686563;Dbxref=PMID:12368295,PMID:12686563
SULF1	Q8IWU6	57	137	87	88	Mutagenesis	Note=Loss of arylsulfatase activity and loss of ability to modulate apoptosis. CC->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12368295,ECO:0000269|PubMed:12686563;Dbxref=PMID:12368295,PMID:12686563
SULF1	Q8IWU6	57	137	87	88	Mutagenesis	Note=Loss of arylsulfatase activity and loss of ability to modulate apoptosis. CC->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12368295,ECO:0000269|PubMed:12686563;Dbxref=PMID:12368295,PMID:12686563
SULF1	Q8IWU6	57	137	87	88	Mutagenesis	Note=Loss of arylsulfatase activity and loss of ability to modulate apoptosis. CC->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12368295,ECO:0000269|PubMed:12686563;Dbxref=PMID:12368295,PMID:12686563
SULF2	Q8IWU5	843	860	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	666	685	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	355	397	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	58	138	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	843	860	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	666	685	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	355	397	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	58	138	25	870	Chain	ID=PRO_0000033440;Note=Extracellular sulfatase Sulf-2
SULF2	Q8IWU5	58	138	88	88	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF2	Q8IWU5	58	138	88	88	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF2	Q8IWU5	58	138	88	88	Metal binding	Note=Calcium%3B via 3-oxoalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SULF2	Q8IWU5	58	138	88	88	Metal binding	Note=Calcium%3B via 3-oxoalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SULF2	Q8IWU5	58	138	88	88	Modified residue	Note=3-oxoalanine (Cys);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF2	Q8IWU5	58	138	88	88	Modified residue	Note=3-oxoalanine (Cys);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15289
SULF2	Q8IWU5	58	138	65	65	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF2	Q8IWU5	58	138	65	65	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF2	Q8IWU5	58	138	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF2	Q8IWU5	58	138	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF2	Q8IWU5	58	138	132	132	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF2	Q8IWU5	58	138	132	132	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SULF2	Q8IWU5	58	138	76	76	Natural variant	ID=VAR_061885;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10574462;Dbxref=dbSNP:rs56218501,PMID:10574462
SULF2	Q8IWU5	58	138	76	76	Natural variant	ID=VAR_061885;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10574462;Dbxref=dbSNP:rs56218501,PMID:10574462
SULF2	Q8IWU5	666	685	674	674	Natural variant	ID=VAR_052518;Note=R->H;Dbxref=dbSNP:rs10048853
SULF2	Q8IWU5	666	685	674	674	Natural variant	ID=VAR_052518;Note=R->H;Dbxref=dbSNP:rs10048853
SULF2	Q8IWU5	58	138	88	89	Mutagenesis	Note=Loss of arylsulfatase activity. CC->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12368295;Dbxref=PMID:12368295
SULF2	Q8IWU5	58	138	88	89	Mutagenesis	Note=Loss of arylsulfatase activity. CC->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12368295;Dbxref=PMID:12368295
SUMO3	P55854	50	74	1	92	Chain	ID=PRO_0000035957;Note=Small ubiquitin-related modifier 3
SUMO3	P55854	7	50	1	92	Chain	ID=PRO_0000035957;Note=Small ubiquitin-related modifier 3
SUMO3	P55854	50	74	15	92	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO3	P55854	7	50	15	92	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
SUMO3	P55854	7	50	7	7	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
SUMO3	P55854	7	50	11	11	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate
SUMO3	P55854	7	50	11	11	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
SUMO3	P55854	50	74	50	50	Alternative sequence	ID=VSP_054693;Note=In isoform 2. Q->QVRHLAPPQSLPVCALVLCVPGIPRARASRGWTQMQLPE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SUMO3	P55854	7	50	50	50	Alternative sequence	ID=VSP_054693;Note=In isoform 2. Q->QVRHLAPPQSLPVCALVLCVPGIPRARASRGWTQMQLPE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SUMO3	P55854	7	50	38	38	Natural variant	ID=VAR_052692;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9119407;Dbxref=dbSNP:rs1051311,PMID:9119407
SUMO3	P55854	7	50	11	11	Mutagenesis	Note=Abolishes the formation of poly(SUMO) chains. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11451954;Dbxref=PMID:11451954
SUMO3	P55854	7	50	33	33	Mutagenesis	Note=Impaired interaction with USP25%3B when associated with A-34. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18538659;Dbxref=PMID:18538659
SUMO3	P55854	7	50	34	34	Mutagenesis	Note=Impaired interaction with USP25%3B when associated with A-33. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18538659;Dbxref=PMID:18538659
SUMO3	P55854	7	50	32	32	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUMO3	P55854	7	50	13	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MP2
SUMO3	P55854	7	50	16	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
SUMO3	P55854	7	50	24	26	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U4A
SUMO3	P55854	7	50	28	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
SUMO3	P55854	7	50	35	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U4A
SUMO3	P55854	50	74	40	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
SUMO3	P55854	7	50	40	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
SUMO3	P55854	50	74	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
SUMO3	P55854	50	74	57	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
SUMO3	P55854	50	74	72	76	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IO1
AARS	P49588	762	800	1	968	Chain	ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic
AARS	P49588	595	664	1	968	Chain	ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic
AARS	P49588	557	595	1	968	Chain	ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic
AARS	P49588	595	664	605	605	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133
AARS	P49588	595	664	609	609	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133
AARS	P49588	595	664	608	608	Natural variant	ID=VAR_073293;Note=Found in a patient with distal hereditary motor neuropathy%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=PMID:24627108
AARS	P49588	762	800	763	763	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
AARS	P49588	762	800	759	782	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T76
AARS	P49588	762	800	789	804	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T76
SYCE1L	A8MT33	85	101	1	242	Chain	ID=PRO_0000341221;Note=Synaptonemal complex central element protein 1-like
SYCE1L	A8MT33	85	101	44	181	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TRAPPC12	Q8WVT3	388	426	1	735	Chain	ID=PRO_0000106401;Note=Trafficking protein particle complex subunit 12
TRAPPC12	Q8WVT3	559	592	1	735	Chain	ID=PRO_0000106401;Note=Trafficking protein particle complex subunit 12
TRAPPC12	Q8WVT3	388	426	1	735	Chain	ID=PRO_0000106401;Note=Trafficking protein particle complex subunit 12
TRAPPC12	Q8WVT3	559	592	1	735	Chain	ID=PRO_0000106401;Note=Trafficking protein particle complex subunit 12
TRAPPC12	Q8WVT3	559	592	545	578	Repeat	Note=TPR 1
TRAPPC12	Q8WVT3	559	592	545	578	Repeat	Note=TPR 1
TRAPPC12	Q8WVT3	559	592	580	613	Repeat	Note=TPR 2
TRAPPC12	Q8WVT3	559	592	580	613	Repeat	Note=TPR 2
TRAPPC12	Q8WVT3	559	592	566	566	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAPPC12	Q8WVT3	559	592	566	566	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SOX13	Q9UN79	110	139	1	622	Chain	ID=PRO_0000048756;Note=Transcription factor SOX-13
SPIRE2	Q8WWL2	96	215	1	714	Chain	ID=PRO_0000320023;Note=Protein spire homolog 2
SPIRE2	Q8WWL2	297	326	1	714	Chain	ID=PRO_0000320023;Note=Protein spire homolog 2
SPIRE2	Q8WWL2	96	215	22	203	Domain	Note=KIND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00709
SPIRE2	Q8WWL2	96	215	1	131	Alternative sequence	ID=VSP_031568;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPIRE2	Q8WWL2	297	326	296	297	Alternative sequence	ID=VSP_031571;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPIRE2	Q8WWL2	297	326	307	307	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM241	Q24JQ0	177	188	1	296	Chain	ID=PRO_0000307316;Note=Transmembrane protein 241
TMEM241	Q24JQ0	93	119	1	296	Chain	ID=PRO_0000307316;Note=Transmembrane protein 241
TMEM241	Q24JQ0	40	65	1	296	Chain	ID=PRO_0000307316;Note=Transmembrane protein 241
TMEM241	Q24JQ0	40	65	32	52	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM241	Q24JQ0	93	119	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM241	Q24JQ0	177	188	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM241	Q24JQ0	40	65	41	66	Alternative sequence	ID=VSP_028704;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM241	Q24JQ0	177	188	150	296	Alternative sequence	ID=VSP_028707;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM241	Q24JQ0	177	188	160	296	Alternative sequence	ID=VSP_028708;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TMEM248	Q9NWD8	260	308	1	314	Chain	ID=PRO_0000295126;Note=Transmembrane protein 248
TMEM248	Q9NWD8	260	308	270	290	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM248	Q9NWD8	260	308	204	314	Alternative sequence	ID=VSP_026737;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPNS2	Q8IVW8	312	362	1	549	Chain	ID=PRO_0000305043;Note=Protein spinster homolog 2
SPNS2	Q8IVW8	426	448	1	549	Chain	ID=PRO_0000305043;Note=Protein spinster homolog 2
SPNS2	Q8IVW8	312	362	320	340	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPNS2	Q8IVW8	426	448	422	442	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPOPL	Q6IQ16	327	344	1	392	Chain	ID=PRO_0000274588;Note=Speckle-type POZ protein-like
TMC1	Q8TDI8	79	120	1	760	Chain	ID=PRO_0000185380;Note=Transmembrane channel-like protein 1
TMC1	Q8TDI8	79	120	1	760	Chain	ID=PRO_0000185380;Note=Transmembrane channel-like protein 1
TMC1	Q8TDI8	79	120	1	199	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC1	Q8TDI8	79	120	1	199	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC1	Q8TDI8	79	120	4	178	Compositional bias	Note=Arg/Asp/Glu/Lys-rich (highly charged)
TMC1	Q8TDI8	79	120	4	178	Compositional bias	Note=Arg/Asp/Glu/Lys-rich (highly charged)
TMC1	Q8TDI8	79	120	81	81	Natural variant	ID=VAR_052333;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850618;Dbxref=dbSNP:rs1796993,PMID:11850618
TMC1	Q8TDI8	79	120	81	81	Natural variant	ID=VAR_052333;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850618;Dbxref=dbSNP:rs1796993,PMID:11850618
SPRTN	Q9H040	107	150	1	489	Chain	ID=PRO_0000312748;Note=SprT-like domain-containing protein Spartan
SPRTN	Q9H040	107	150	45	212	Domain	Note=SprT-like
SPRTN	Q9H040	107	150	108	150	Alternative sequence	ID=VSP_046925;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPRTN	Q9H040	107	150	117	117	Natural variant	ID=VAR_072708;Note=In RJALS%3B cells ectopically expressing the mutant are completely unable to restore DNA replication fork progression. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25261934;Dbxref=dbSNP:rs527236213,PMID:25261934
TMC6	Q7Z403	512	571	1	805	Chain	ID=PRO_0000185384;Note=Transmembrane channel-like protein 6
TMC6	Q7Z403	409	461	1	805	Chain	ID=PRO_0000185384;Note=Transmembrane channel-like protein 6
TMC6	Q7Z403	512	571	1	805	Chain	ID=PRO_0000185384;Note=Transmembrane channel-like protein 6
TMC6	Q7Z403	409	461	1	805	Chain	ID=PRO_0000185384;Note=Transmembrane channel-like protein 6
TMC6	Q7Z403	512	571	1	805	Chain	ID=PRO_0000185384;Note=Transmembrane channel-like protein 6
TMC6	Q7Z403	409	461	1	805	Chain	ID=PRO_0000185384;Note=Transmembrane channel-like protein 6
TMC6	Q7Z403	409	461	360	431	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	360	431	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	360	431	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	432	452	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	432	452	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	432	452	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	453	469	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	453	469	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	409	461	453	469	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	506	526	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	506	526	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	506	526	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	527	553	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	527	553	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	527	553	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	554	574	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	554	574	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	554	574	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC6	Q7Z403	512	571	410	760	Alternative sequence	ID=VSP_016439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12426567;Dbxref=PMID:12426567
TMC6	Q7Z403	409	461	410	760	Alternative sequence	ID=VSP_016439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12426567;Dbxref=PMID:12426567
TMC6	Q7Z403	512	571	410	760	Alternative sequence	ID=VSP_016439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12426567;Dbxref=PMID:12426567
TMC6	Q7Z403	409	461	410	760	Alternative sequence	ID=VSP_016439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12426567;Dbxref=PMID:12426567
TMC6	Q7Z403	512	571	410	760	Alternative sequence	ID=VSP_016439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12426567;Dbxref=PMID:12426567
TMC6	Q7Z403	409	461	410	760	Alternative sequence	ID=VSP_016439;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12426567;Dbxref=PMID:12426567
TMC6	Q7Z403	512	571	512	571	Alternative sequence	ID=VSP_016440;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TMC6	Q7Z403	512	571	512	571	Alternative sequence	ID=VSP_016440;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TMC6	Q7Z403	512	571	512	571	Alternative sequence	ID=VSP_016440;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TMC6	Q7Z403	512	571	513	525	Alternative sequence	ID=VSP_016441;Note=In isoform 4. NLILKLAILGTLC->CVAAHENIIWCWS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMC6	Q7Z403	512	571	513	525	Alternative sequence	ID=VSP_016441;Note=In isoform 4. NLILKLAILGTLC->CVAAHENIIWCWS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMC6	Q7Z403	512	571	513	525	Alternative sequence	ID=VSP_016441;Note=In isoform 4. NLILKLAILGTLC->CVAAHENIIWCWS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMC6	Q7Z403	512	571	526	805	Alternative sequence	ID=VSP_016442;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMC6	Q7Z403	512	571	526	805	Alternative sequence	ID=VSP_016442;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMC6	Q7Z403	512	571	526	805	Alternative sequence	ID=VSP_016442;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMC6	Q7Z403	512	571	556	556	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMC6	Q7Z403	512	571	556	556	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMC6	Q7Z403	512	571	556	556	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMED9	Q9BVK6	137	186	38	235	Chain	ID=PRO_0000010396;Note=Transmembrane emp24 domain-containing protein 9
TMED9	Q9BVK6	137	186	38	202	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMED9	Q9BVK6	137	186	47	145	Domain	Note=GOLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00096
TMED9	Q9BVK6	137	186	121	160	Region	Note=Required for interaction with STX17;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21545355;Dbxref=PMID:21545355
TMED9	Q9BVK6	137	186	154	184	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMED9	Q9BVK6	137	186	160	160	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KF1
TMED9	Q9BVK6	137	186	156	156	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SREK1	Q8WXA9	258	378	1	508	Chain	ID=PRO_0000081940;Note=Splicing regulatory glutamine/lysine-rich protein 1
SREK1	Q8WXA9	258	378	190	474	Compositional bias	Note=Arg/Glu/Lys/Ser-rich
SREK1	Q8WXA9	258	378	363	363	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRBD1	Q8N5C6	470	505	1	995	Chain	ID=PRO_0000284357;Note=S1 RNA-binding domain-containing protein 1
TMEM68	Q96MH6	108	164	1	324	Chain	ID=PRO_0000254592;Note=Transmembrane protein 68
TMEM68	Q96MH6	108	164	126	146	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM68	Q96MH6	108	164	110	135	Alternative sequence	ID=VSP_021244;Note=In isoform 3. YEVHGMEKIPEDGPALIIFYHGAIPI->KQGYFHLCVAIHVCCIGTVLPFHFID;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM68	Q96MH6	108	164	136	324	Alternative sequence	ID=VSP_021245;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SRCAP	Q6ZRS2	1084	1180	1	3230	Chain	ID=PRO_0000311236;Note=Helicase SRCAP
SRCAP	Q6ZRS2	1235	1297	1	3230	Chain	ID=PRO_0000311236;Note=Helicase SRCAP
SRCAP	Q6ZRS2	2308	2336	1	3230	Chain	ID=PRO_0000311236;Note=Helicase SRCAP
SRCAP	Q6ZRS2	1084	1180	981	1883	Compositional bias	Note=Pro-rich
SRCAP	Q6ZRS2	1235	1297	981	1883	Compositional bias	Note=Pro-rich
SRCAP	Q6ZRS2	2308	2336	2227	2362	Compositional bias	Note=Glu-rich
SRCAP	Q6ZRS2	1084	1180	1172	1172	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SRCAP	Q6ZRS2	1084	1180	1085	1181	Alternative sequence	ID=VSP_029441;Note=In isoform 3. VLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPS->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
SRCAP	Q6ZRS2	1235	1297	1236	1298	Alternative sequence	ID=VSP_029442;Note=In isoform 2 and isoform 3. RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV->M;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10347196,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9205841;Dbxref=PMID:10347196,PMID:15489334,PMID:9205841
SRCAP	Q6ZRS2	1084	1180	1147	1147	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
HRC	P23327	634	657	29	699	Chain	ID=PRO_0000022414;Note=Sarcoplasmic reticulum histidine-rich calcium-binding protein
HRC	P23327	634	657	627	673	Region	Note=Metal-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM9B	Q9NQ34	102	147	34	198	Chain	ID=PRO_0000034376;Note=Transmembrane protein 9B
TMEM9B	Q9NQ34	102	147	105	125	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM9B	Q9NQ34	102	147	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JJR8
TMOD3	Q9NYL9	209	245	1	352	Chain	ID=PRO_0000186134;Note=Tropomodulin-3
TMPRSS3	P57727	149	190	1	454	Chain	ID=PRO_0000088690;Note=Transmembrane protease serine 3
TMPRSS3	P57727	31	68	1	454	Chain	ID=PRO_0000088690;Note=Transmembrane protease serine 3
TMPRSS3	P57727	149	190	1	454	Chain	ID=PRO_0000088690;Note=Transmembrane protease serine 3
TMPRSS3	P57727	31	68	1	454	Chain	ID=PRO_0000088690;Note=Transmembrane protease serine 3
TMPRSS3	P57727	31	68	1	48	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS3	P57727	31	68	1	48	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS3	P57727	31	68	49	69	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS3	P57727	31	68	49	69	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS3	P57727	149	190	70	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS3	P57727	149	190	70	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS3	P57727	149	190	109	205	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
TMPRSS3	P57727	149	190	109	205	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
TMPRSS3	P57727	149	190	129	194	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS3	P57727	149	190	129	194	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS3	P57727	149	190	142	204	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS3	P57727	149	190	142	204	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS3	P57727	31	68	1	127	Alternative sequence	ID=VSP_005391;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11137999;Dbxref=PMID:11137999
TMPRSS3	P57727	31	68	1	127	Alternative sequence	ID=VSP_005391;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11137999;Dbxref=PMID:11137999
TMPRSS3	P57727	31	68	53	53	Natural variant	ID=VAR_010781;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11137999,ECO:0000269|PubMed:11424922;Dbxref=dbSNP:rs928302,PMID:11137999,PMID:11424922
TMPRSS3	P57727	31	68	53	53	Natural variant	ID=VAR_010781;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11137999,ECO:0000269|PubMed:11424922;Dbxref=dbSNP:rs928302,PMID:11137999,PMID:11424922
TMPRSS3	P57727	149	190	173	173	Natural variant	ID=VAR_013493;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11907649;Dbxref=dbSNP:rs766000719,PMID:11907649
TMPRSS3	P57727	149	190	173	173	Natural variant	ID=VAR_013493;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11907649;Dbxref=dbSNP:rs766000719,PMID:11907649
TMPRSS3	P57727	31	68	46	54	Sequence conflict	Note=LKFFPIIVI->FEVFSQSSSL;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMPRSS3	P57727	31	68	46	54	Sequence conflict	Note=LKFFPIIVI->FEVFSQSSSL;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMPRSS4	Q9NRS4	14	52	1	437	Chain	ID=PRO_0000088692;Note=Transmembrane protease serine 4
TMPRSS4	Q9NRS4	52	103	1	437	Chain	ID=PRO_0000088692;Note=Transmembrane protease serine 4
TMPRSS4	Q9NRS4	14	52	1	32	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS4	Q9NRS4	14	52	33	53	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS4	Q9NRS4	52	103	33	53	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS4	Q9NRS4	52	103	54	437	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS4	Q9NRS4	52	103	61	93	Domain	Note=LDL-receptor class A
TMPRSS4	Q9NRS4	52	103	94	204	Domain	Note=SRCR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
TMPRSS4	Q9NRS4	52	103	64	83	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS4	Q9NRS4	52	103	77	92	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TMPRSS4	Q9NRS4	14	52	14	53	Alternative sequence	ID=VSP_054229;Note=In isoform 4. LDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLI->LV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMPRSS4	Q9NRS4	52	103	14	53	Alternative sequence	ID=VSP_054229;Note=In isoform 4. LDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLI->LV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMTC4	Q5T4D3	228	259	1	741	Chain	ID=PRO_0000280295;Note=Transmembrane and TPR repeat-containing protein 4
TMTC4	Q5T4D3	228	259	225	245	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SSBP3	Q9BWW4	255	267	1	388	Chain	ID=PRO_0000123828;Note=Single-stranded DNA-binding protein 3
SSBP3	Q9BWW4	149	169	1	388	Chain	ID=PRO_0000123828;Note=Single-stranded DNA-binding protein 3
SSBP3	Q9BWW4	122	149	1	388	Chain	ID=PRO_0000123828;Note=Single-stranded DNA-binding protein 3
SSBP3	Q9BWW4	255	267	98	319	Compositional bias	Note=Pro-rich
SSBP3	Q9BWW4	149	169	98	319	Compositional bias	Note=Pro-rich
SSBP3	Q9BWW4	122	149	98	319	Compositional bias	Note=Pro-rich
SSBP3	Q9BWW4	255	267	158	369	Compositional bias	Note=Gly-rich
SSBP3	Q9BWW4	149	169	158	369	Compositional bias	Note=Gly-rich
SSBP3	Q9BWW4	149	169	155	155	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SSBP3	Q9BWW4	149	169	161	161	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SSBP3	Q9BWW4	149	169	165	165	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SSBP3	Q9BWW4	149	169	123	149	Alternative sequence	ID=VSP_006260;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSBP3	Q9BWW4	122	149	123	149	Alternative sequence	ID=VSP_006260;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SSBP3	Q9BWW4	149	169	150	169	Alternative sequence	ID=VSP_006261;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
SHC3	Q92529	243	261	1	594	Chain	ID=PRO_0000097734;Note=SHC-transforming protein 3
SHC3	Q92529	243	261	149	334	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
INPPL1	O15357	173	219	1	1258	Chain	ID=PRO_0000302870;Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate 5-phosphatase 2
INPPL1	O15357	251	281	1	1258	Chain	ID=PRO_0000302870;Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate 5-phosphatase 2
INPPL1	O15357	173	219	1	242	Alternative sequence	ID=VSP_027985;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8530088;Dbxref=PMID:8530088
SNX30	Q5VWJ9	116	153	1	437	Chain	ID=PRO_0000284533;Note=Sorting nexin-30
SNX30	Q5VWJ9	338	367	1	437	Chain	ID=PRO_0000284533;Note=Sorting nexin-30
SNX30	Q5VWJ9	116	153	89	210	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX30	Q5VWJ9	116	153	125	125	Natural variant	ID=VAR_052483;Note=P->A;Dbxref=dbSNP:rs10117709
SLCO3A1	Q9UIG8	215	248	1	710	Chain	ID=PRO_0000191064;Note=Solute carrier organic anion transporter family member 3A1
SLCO3A1	Q9UIG8	248	336	1	710	Chain	ID=PRO_0000191064;Note=Solute carrier organic anion transporter family member 3A1
SLCO3A1	Q9UIG8	215	248	204	222	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO3A1	Q9UIG8	215	248	223	243	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO3A1	Q9UIG8	215	248	244	261	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO3A1	Q9UIG8	248	336	244	261	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO3A1	Q9UIG8	248	336	262	286	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO3A1	Q9UIG8	248	336	287	344	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO3A1	Q9UIG8	215	248	1	281	Alternative sequence	ID=VSP_036833;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLCO3A1	Q9UIG8	248	336	1	281	Alternative sequence	ID=VSP_036833;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLCO3A1	Q9UIG8	248	336	294	294	Natural variant	ID=VAR_054853;Note=E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10873595,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1517618,PMID:10873595,PMID:14702039,PMID:15489334
SOAT2	O75908	92	111	1	522	Chain	ID=PRO_0000207645;Note=Sterol O-acyltransferase 2
SOAT2	O75908	92	111	1	122	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SOAT2	O75908	92	111	93	148	Alternative sequence	ID=VSP_057158;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16331323;Dbxref=PMID:16331323
SOAT2	O75908	92	111	93	112	Alternative sequence	ID=VSP_057159;Note=In isoform 2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16331323;Dbxref=PMID:16331323
NABP2	Q9BQ15	73	96	1	211	Chain	ID=PRO_0000333958;Note=SOSS complex subunit B1
NABP2	Q9BQ15	73	96	1	211	Chain	ID=PRO_0000333958;Note=SOSS complex subunit B1
NABP2	Q9BQ15	73	96	1	211	Chain	ID=PRO_0000333958;Note=SOSS complex subunit B1
NABP2	Q9BQ15	73	96	22	92	DNA binding	Note=OB
NABP2	Q9BQ15	73	96	22	92	DNA binding	Note=OB
NABP2	Q9BQ15	73	96	22	92	DNA binding	Note=OB
NABP2	Q9BQ15	73	96	1	99	Alternative sequence	ID=VSP_033604;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
NABP2	Q9BQ15	73	96	1	99	Alternative sequence	ID=VSP_033604;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
NABP2	Q9BQ15	73	96	1	99	Alternative sequence	ID=VSP_033604;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
NABP2	Q9BQ15	73	96	93	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OWT
NABP2	Q9BQ15	73	96	93	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OWT
NABP2	Q9BQ15	73	96	93	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OWT
SERPINB6	P35237	55	104	1	376	Chain	ID=PRO_0000094106;Note=Serpin B6
SERPINB6	P35237	55	104	1	376	Chain	ID=PRO_0000094106;Note=Serpin B6
SERPINB6	P35237	55	104	1	376	Chain	ID=PRO_0000094106;Note=Serpin B6
SERPINB6	P35237	55	104	1	376	Chain	ID=PRO_0000094106;Note=Serpin B6
SERPINB6	P35237	55	104	1	376	Chain	ID=PRO_0000094106;Note=Serpin B6
SERPINB6	P35237	55	104	90	90	Natural variant	ID=VAR_037295;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:8136380,ECO:0000269|PubMed:8415716;Dbxref=dbSNP:rs2295769,PMID:14702039,PMID:17974005,PMID:8136380,PMID:8415716
SERPINB6	P35237	55	104	90	90	Natural variant	ID=VAR_037295;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:8136380,ECO:0000269|PubMed:8415716;Dbxref=dbSNP:rs2295769,PMID:14702039,PMID:17974005,PMID:8136380,PMID:8415716
SERPINB6	P35237	55	104	90	90	Natural variant	ID=VAR_037295;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:8136380,ECO:0000269|PubMed:8415716;Dbxref=dbSNP:rs2295769,PMID:14702039,PMID:17974005,PMID:8136380,PMID:8415716
SERPINB6	P35237	55	104	90	90	Natural variant	ID=VAR_037295;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:8136380,ECO:0000269|PubMed:8415716;Dbxref=dbSNP:rs2295769,PMID:14702039,PMID:17974005,PMID:8136380,PMID:8415716
SERPINB6	P35237	55	104	90	90	Natural variant	ID=VAR_037295;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:8136380,ECO:0000269|PubMed:8415716;Dbxref=dbSNP:rs2295769,PMID:14702039,PMID:17974005,PMID:8136380,PMID:8415716
SERPINB13	Q9UIV8	75	118	1	391	Chain	ID=PRO_0000094121;Note=Serpin B13
SERPINB13	Q9UIV8	205	257	1	391	Chain	ID=PRO_0000094121;Note=Serpin B13
SERPINB13	Q9UIV8	205	257	206	257	Alternative sequence	ID=VSP_006058;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SERPINB13	Q9UIV8	75	118	75	75	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPDL1	Q96EA4	297	344	1	605	Chain	ID=PRO_0000274516;Note=Protein Spindly
SPDL1	Q96EA4	297	344	2	442	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03041
SPDL1	Q96EA4	297	344	329	329	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM198	Q66K66	55	247	1	360	Chain	ID=PRO_0000326030;Note=Transmembrane protein 198
TMEM198	Q66K66	55	247	1	360	Chain	ID=PRO_0000326030;Note=Transmembrane protein 198
TMEM198	Q66K66	55	247	36	56	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	36	56	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	59	79	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	59	79	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	177	197	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	177	197	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	218	238	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM198	Q66K66	55	247	64	233	Compositional bias	Note=Leu-rich
TMEM198	Q66K66	55	247	64	233	Compositional bias	Note=Leu-rich
TMEM213	A2RRL7	27	51	1	27	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM213	A2RRL7	27	51	28	107	Chain	ID=PRO_0000337054;Note=Transmembrane protein 213
TMEM213	A2RRL7	27	51	28	70	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM213	A2RRL7	27	51	28	52	Alternative sequence	ID=VSP_039555;Note=In isoform 2. EASSSNSSSLTAHHPDPGTLEQCLN->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM213	A2RRL7	27	51	28	28	Alternative sequence	ID=VSP_039556;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SERPINI2	O75830	82	159	19	405	Chain	ID=PRO_0000032525;Note=Serpin I2
SERPINI2	O75830	82	159	19	405	Chain	ID=PRO_0000032525;Note=Serpin I2
SERPINI2	O75830	82	159	19	405	Chain	ID=PRO_0000032525;Note=Serpin I2
SERPINI2	O75830	82	159	19	405	Chain	ID=PRO_0000032525;Note=Serpin I2
SERPINI2	O75830	82	159	148	148	Natural variant	ID=VAR_024357;Note=E->G;Dbxref=dbSNP:rs9841174
SERPINI2	O75830	82	159	148	148	Natural variant	ID=VAR_024357;Note=E->G;Dbxref=dbSNP:rs9841174
SERPINI2	O75830	82	159	148	148	Natural variant	ID=VAR_024357;Note=E->G;Dbxref=dbSNP:rs9841174
SERPINI2	O75830	82	159	148	148	Natural variant	ID=VAR_024357;Note=E->G;Dbxref=dbSNP:rs9841174
TM7SF3	Q9NS93	345	396	22	570	Chain	ID=PRO_0000022537;Note=Transmembrane 7 superfamily member 3
TM7SF3	Q9NS93	318	345	22	570	Chain	ID=PRO_0000022537;Note=Transmembrane 7 superfamily member 3
TM7SF3	Q9NS93	289	318	22	570	Chain	ID=PRO_0000022537;Note=Transmembrane 7 superfamily member 3
TM7SF3	Q9NS93	289	318	296	313	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF3	Q9NS93	318	345	320	342	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF3	Q9NS93	345	396	347	369	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF3	Q9NS93	345	396	371	393	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM7SF3	Q9NS93	318	345	297	332	Compositional bias	Note=Phe-rich
TM7SF3	Q9NS93	289	318	297	332	Compositional bias	Note=Phe-rich
SPPL2A	Q8TCT8	416	442	26	520	Chain	ID=PRO_0000073910;Note=Signal peptide peptidase-like 2A
SPPL2A	Q8TCT8	363	382	26	520	Chain	ID=PRO_0000073910;Note=Signal peptide peptidase-like 2A
SPPL2A	Q8TCT8	338	363	26	520	Chain	ID=PRO_0000073910;Note=Signal peptide peptidase-like 2A
SPPL2A	Q8TCT8	338	363	333	340	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPPL2A	Q8TCT8	338	363	341	361	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPPL2A	Q8TCT8	363	382	362	399	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15385547;Dbxref=PMID:15385547
SPPL2A	Q8TCT8	338	363	362	399	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15385547;Dbxref=PMID:15385547
SPPL2A	Q8TCT8	416	442	400	420	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPPL2A	Q8TCT8	416	442	421	437	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPPL2A	Q8TCT8	416	442	438	458	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPPL2A	Q8TCT8	338	363	351	351	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49810
SPRYD3	Q8NCJ5	300	340	1	442	Chain	ID=PRO_0000240854;Note=SPRY domain-containing protein 3
SPRYD3	Q8NCJ5	169	231	1	442	Chain	ID=PRO_0000240854;Note=SPRY domain-containing protein 3
SPRYD3	Q8NCJ5	169	231	17	204	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
SPRYD3	Q8NCJ5	169	231	168	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YYO
SPRYD3	Q8NCJ5	169	231	179	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YYO
SPRYD3	Q8NCJ5	169	231	183	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YYO
SPRYD3	Q8NCJ5	169	231	193	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YYO
TMED2	Q15363	124	160	21	201	Chain	ID=PRO_0000010381;Note=Transmembrane emp24 domain-containing protein 2
TMED2	Q15363	124	160	21	168	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMED2	Q15363	124	160	1	181	Region	Note=Interaction with F2RL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17693410;Dbxref=PMID:17693410
TMED2	Q15363	124	160	118	157	Region	Note=Required for TMED10 and TMED2 cis-Golgi network localization
TMED2	Q15363	124	160	117	167	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMED4	Q7Z7H5	129	178	30	227	Chain	ID=PRO_0000010387;Note=Transmembrane emp24 domain-containing protein 4
TMED4	Q7Z7H5	129	178	30	194	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMED4	Q7Z7H5	129	178	39	137	Domain	Note=GOLD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00096
TMED4	Q7Z7H5	129	178	147	176	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPATA20	Q8TB22	315	350	23	786	Chain	ID=PRO_0000278450;Note=Spermatogenesis-associated protein 20
SQSTM1	Q13501	224	251	2	440	Chain	ID=PRO_0000072176;Note=Sequestosome-1
SQSTM1	Q13501	224	251	122	224	Region	Note=Interaction with GABRR3;Ontology_term=ECO:0000250;evidence=ECO:0000250
SQSTM1	Q13501	224	251	228	233	Motif	Note=TRAF6-binding
SQSTM1	Q13501	224	251	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SQSTM1	Q13501	224	251	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
SQSTM1	Q13501	224	251	226	226	Natural variant	ID=VAR_073919;Note=In FTDALS3. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24899140;Dbxref=dbSNP:rs765200636,PMID:24899140
SQSTM1	Q13501	224	251	228	228	Natural variant	ID=VAR_073920;Note=In FTDALS3. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22084127,ECO:0000269|PubMed:24899140;Dbxref=dbSNP:rs151191977,PMID:22084127,PMID:24899140
SQSTM1	Q13501	224	251	232	232	Natural variant	ID=VAR_073921;Note=In FTDALS3. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24899140;Dbxref=PMID:24899140
SQSTM1	Q13501	224	251	238	238	Natural variant	ID=VAR_068915;Note=Polymorphism%3B confirmed at protein level. K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17488105,ECO:0000269|PubMed:24899140;Dbxref=dbSNP:rs11548633,PMID:17488105,PMID:24899140
SQSTM1	Q13501	224	251	238	238	Natural variant	ID=VAR_073922;Note=In FTDALS3. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22084127,ECO:0000269|PubMed:24899140,ECO:0000269|PubMed:25114083;Dbxref=PMID:22084127,PMID:24899140,PMID:25114083
SCN11A	Q9UI33	674	801	1	1791	Chain	ID=PRO_0000048510;Note=Sodium channel protein type 11 subunit alpha
SCN11A	Q9UI33	367	433	1	1791	Chain	ID=PRO_0000048510;Note=Sodium channel protein type 11 subunit alpha
SCN11A	Q9UI33	367	433	345	369	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN11A	Q9UI33	367	433	370	376	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	367	433	377	402	Transmembrane	Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250
SCN11A	Q9UI33	367	433	403	572	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	668	687	Transmembrane	Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250
SCN11A	Q9UI33	674	801	688	702	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	703	725	Transmembrane	Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250
SCN11A	Q9UI33	674	801	726	753	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	754	774	Intramembrane	Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN11A	Q9UI33	674	801	775	785	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	786	811	Transmembrane	Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250
SCN11A	Q9UI33	367	433	115	408	Repeat	Note=I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	559	833	Repeat	Note=II;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	781	781	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SCN11A	Q9UI33	674	801	776	787	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2
SCN11A	Q9UI33	367	433	381	381	Natural variant	ID=VAR_076682;Note=In FEPS3%3B causes hyperexcitability of dorsal root ganglion neurons%3B depolarizes resting membrane potential%3B enhances spontaneous firing%3B hyperpolarizes channel activation%3B slows deactivation%3B decreases rates of current decay%3B does not change slow-inactivation. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24776970;Dbxref=dbSNP:rs606231280,PMID:24776970
SCN11A	Q9UI33	367	433	419	419	Natural variant	ID=VAR_076683;Note=K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24776970;Dbxref=dbSNP:rs150269814,PMID:24776970
SCN11A	Q9UI33	674	801	681	681	Natural variant	ID=VAR_076685;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24776970;Dbxref=PMID:24776970
SCN11A	Q9UI33	674	801	699	699	Natural variant	ID=VAR_076686;Note=In FEPS3%3B causes hyperexcitability of dorsal root ganglion neurons%3B hyperpolarizes channel activation%3B slows deactivation%3B depolarizes steady-state fast-inactivation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25791876;Dbxref=dbSNP:rs145734191,PMID:25791876
SCN11A	Q9UI33	674	801	777	777	Natural variant	ID=VAR_030003;Note=M->R;Dbxref=dbSNP:rs4302324
SCN11A	Q9UI33	674	801	703	703	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCN11A	Q9UI33	674	801	703	703	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
THRB	P10828	246	295	1	461	Chain	ID=PRO_0000053446;Note=Thyroid hormone receptor beta
THRB	P10828	7	94	1	461	Chain	ID=PRO_0000053446;Note=Thyroid hormone receptor beta
THRB	P10828	246	295	1	461	Chain	ID=PRO_0000053446;Note=Thyroid hormone receptor beta
THRB	P10828	7	94	1	461	Chain	ID=PRO_0000053446;Note=Thyroid hormone receptor beta
THRB	P10828	246	295	1	461	Chain	ID=PRO_0000053446;Note=Thyroid hormone receptor beta
THRB	P10828	7	94	1	461	Chain	ID=PRO_0000053446;Note=Thyroid hormone receptor beta
THRB	P10828	246	295	217	461	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
THRB	P10828	246	295	217	461	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
THRB	P10828	246	295	217	461	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
THRB	P10828	7	94	1	106	Region	Note=Modulating
THRB	P10828	7	94	1	106	Region	Note=Modulating
THRB	P10828	7	94	1	106	Region	Note=Modulating
THRB	P10828	246	295	244	461	Region	Note=Interaction with NR2F6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10713182;Dbxref=PMID:10713182
THRB	P10828	246	295	244	461	Region	Note=Interaction with NR2F6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10713182;Dbxref=PMID:10713182
THRB	P10828	246	295	244	461	Region	Note=Interaction with NR2F6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10713182;Dbxref=PMID:10713182
THRB	P10828	246	295	282	282	Binding site	Note=Thyroid hormone
THRB	P10828	246	295	282	282	Binding site	Note=Thyroid hormone
THRB	P10828	246	295	282	282	Binding site	Note=Thyroid hormone
THRB	P10828	7	94	1	93	Alternative sequence	ID=VSP_031077;Note=In isoform Beta-2. MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKC->MNYCMQEIYEVHPAAGSNCYMQSTDYYAYFEDSPGYSGCDAQAVPSNNIYMEQAWAVNQPYTCSYPGNMFKSKDSDLDMALNQYSQPEYFTEEKPTFSQVQSPSYSQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
THRB	P10828	7	94	1	93	Alternative sequence	ID=VSP_031077;Note=In isoform Beta-2. MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKC->MNYCMQEIYEVHPAAGSNCYMQSTDYYAYFEDSPGYSGCDAQAVPSNNIYMEQAWAVNQPYTCSYPGNMFKSKDSDLDMALNQYSQPEYFTEEKPTFSQVQSPSYSQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
THRB	P10828	7	94	1	93	Alternative sequence	ID=VSP_031077;Note=In isoform Beta-2. MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKC->MNYCMQEIYEVHPAAGSNCYMQSTDYYAYFEDSPGYSGCDAQAVPSNNIYMEQAWAVNQPYTCSYPGNMFKSKDSDLDMALNQYSQPEYFTEEKPTFSQVQSPSYSQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
THRB	P10828	246	295	268	268	Natural variant	ID=VAR_059041;Note=In GTHR. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19268523;Dbxref=PMID:19268523
THRB	P10828	246	295	268	268	Natural variant	ID=VAR_059041;Note=In GTHR. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19268523;Dbxref=PMID:19268523
THRB	P10828	246	295	268	268	Natural variant	ID=VAR_059041;Note=In GTHR. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19268523;Dbxref=PMID:19268523
THRB	P10828	246	295	248	251	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	248	251	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	248	251	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	260	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	260	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	260	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	266	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	266	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	266	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	276	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	276	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	276	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THRB	P10828	246	295	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N46
THEG	Q9P2T0	144	167	1	379	Chain	ID=PRO_0000306267;Note=Testicular haploid expressed gene protein
THEG	Q9P2T0	144	167	145	168	Alternative sequence	ID=VSP_028446;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11173852;Dbxref=PMID:11173852
THEM4	Q5T1C6	149	185	37	240	Chain	ID=PRO_0000314179;Note=Acyl-coenzyme A thioesterase THEM4
THEM4	Q5T1C6	149	185	161	161	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22871024;Dbxref=PMID:22871024
THEM4	Q5T1C6	149	185	183	183	Binding site	Note=Substrate
THEM4	Q5T1C6	149	185	185	185	Binding site	Note=Substrate
THEM4	Q5T1C6	149	185	152	152	Mutagenesis	Note=Strongly reduced enzyme activity. H->A%2CF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22871024;Dbxref=PMID:22871024
THEM4	Q5T1C6	149	185	161	161	Mutagenesis	Note=Nearly abolishes enzyme activity. Strongly reduced affinity for myristoyl-CoA. D->E%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22871024;Dbxref=PMID:22871024
THEM4	Q5T1C6	149	185	177	177	Mutagenesis	Note=Strongly reduced enzyme activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22871024;Dbxref=PMID:22871024
THEM4	Q5T1C6	149	185	183	183	Mutagenesis	Note=No effect on enzyme activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22871024;Dbxref=PMID:22871024
THEM4	Q5T1C6	149	185	153	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AE8
THEM4	Q5T1C6	149	185	175	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AE8
SDS	P20132	142	217	1	328	Chain	ID=PRO_0000185594;Note=L-serine dehydratase/L-threonine deaminase
SDS	P20132	142	217	183	183	Sequence conflict	Note=V->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
SDS	P20132	142	217	139	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDS	P20132	142	217	147	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDS	P20132	142	217	161	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDS	P20132	142	217	168	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDS	P20132	142	217	171	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDS	P20132	142	217	190	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDS	P20132	142	217	200	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H27
SDK1	Q7Z5N4	1997	2043	2010	2030	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK1	Q7Z5N4	1997	2043	2031	2213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK1	Q7Z5N4	515	571	480	569	Domain	Note=Ig-like C2-type 5
SDK1	Q7Z5N4	1645	1665	1581	1699	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
SDK1	Q7Z5N4	1997	2043	1902	2000	Domain	Note=Fibronectin type-III 13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
SDK1	Q7Z5N4	515	571	550	550	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK1	Q7Z5N4	515	571	563	563	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK1	Q7Z5N4	1645	1665	1654	1654	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK1	Q7Z5N4	515	571	501	553	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SDK1	Q7Z5N4	515	571	1	1940	Alternative sequence	ID=VSP_017517;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SDK1	Q7Z5N4	1645	1665	1	1940	Alternative sequence	ID=VSP_017517;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SDK1	Q7Z5N4	1645	1665	1643	1662	Alternative sequence	ID=VSP_017518;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SEMA3G	Q9NS98	92	113	23	782	Chain	ID=PRO_0000257791;Note=Semaphorin-3G
SEMA3G	Q9NS98	92	113	32	519	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA3G	Q9NS98	92	113	105	116	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SEMA4A	Q9H3S1	121	154	33	761	Chain	ID=PRO_0000032322;Note=Semaphorin-4A
SEMA4A	Q9H3S1	121	154	33	761	Chain	ID=PRO_0000032322;Note=Semaphorin-4A
SEMA4A	Q9H3S1	121	154	33	761	Chain	ID=PRO_0000032322;Note=Semaphorin-4A
SEMA4A	Q9H3S1	121	154	33	683	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4A	Q9H3S1	121	154	33	683	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4A	Q9H3S1	121	154	33	683	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4A	Q9H3S1	121	154	36	494	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	36	494	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	36	494	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4A	Q9H3S1	121	154	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4A	Q9H3S1	121	154	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4A	Q9H3S1	121	154	113	124	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	113	124	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	113	124	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	142	151	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	142	151	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	142	151	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4A	Q9H3S1	121	154	122	154	Alternative sequence	ID=VSP_046382;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEMA4A	Q9H3S1	121	154	122	154	Alternative sequence	ID=VSP_046382;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEMA4A	Q9H3S1	121	154	122	154	Alternative sequence	ID=VSP_046382;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SF3A3	Q12874	390	427	1	501	Chain	ID=PRO_0000174318;Note=Splicing factor 3A subunit 3
SF3A3	Q12874	276	311	1	501	Chain	ID=PRO_0000174318;Note=Splicing factor 3A subunit 3
SF3A3	Q12874	390	427	406	437	Zinc finger	Note=Matrin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00130
SF3A3	Q12874	276	311	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SF3A3	Q12874	276	311	299	299	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
SFSWAP	Q12872	441	484	1	951	Chain	ID=PRO_0000081934;Note=Splicing factor%2C suppressor of white-apricot homolog
SFSWAP	Q12872	573	650	1	951	Chain	ID=PRO_0000081934;Note=Splicing factor%2C suppressor of white-apricot homolog
SFSWAP	Q12872	803	844	1	951	Chain	ID=PRO_0000081934;Note=Splicing factor%2C suppressor of white-apricot homolog
SFSWAP	Q12872	845	905	1	951	Chain	ID=PRO_0000081934;Note=Splicing factor%2C suppressor of white-apricot homolog
SFSWAP	Q12872	441	484	459	499	Repeat	Note=SURP motif 2
SFSWAP	Q12872	441	484	451	454	Compositional bias	Note=Poly-Pro
SFSWAP	Q12872	573	650	616	619	Compositional bias	Note=Poly-Ser
SFSWAP	Q12872	803	844	789	951	Compositional bias	Note=Arg/Ser-rich (RS domain)
SFSWAP	Q12872	845	905	789	951	Compositional bias	Note=Arg/Ser-rich (RS domain)
SFSWAP	Q12872	845	905	850	853	Compositional bias	Note=Poly-Lys
SFSWAP	Q12872	573	650	604	604	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:24275569
SFSWAP	Q12872	573	650	642	642	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
SFSWAP	Q12872	803	844	832	832	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SFSWAP	Q12872	803	844	834	834	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SFSWAP	Q12872	845	905	905	905	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3USH5
SFSWAP	Q12872	845	905	887	887	Natural variant	ID=VAR_057250;Note=A->E;Dbxref=dbSNP:rs34729193
SFSWAP	Q12872	441	484	454	456	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5Z
SFSWAP	Q12872	441	484	457	469	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5Z
SFSWAP	Q12872	441	484	472	481	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5Z
SFSWAP	Q12872	441	484	484	486	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E5Z
SGCA	Q16586	12	52	1	23	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
SGCA	Q16586	12	52	24	387	Chain	ID=PRO_0000031673;Note=Alpha-sarcoglycan
SGCA	Q16586	12	52	24	290	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGCA	Q16586	12	52	30	30	Natural variant	ID=VAR_010402;Note=In LGMD2D. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9192266;Dbxref=dbSNP:rs886043256,PMID:9192266
SGCA	Q16586	12	52	31	31	Natural variant	ID=VAR_010403;Note=In LGMD2D. L->P;Dbxref=dbSNP:rs903823830
SGCA	Q16586	12	52	34	34	Natural variant	ID=VAR_010404;Note=In LGMD2D. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9192266;Dbxref=dbSNP:rs758647756,PMID:9192266
SGCA	Q16586	12	52	34	34	Natural variant	ID=VAR_010405;Note=In LGMD2D. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7663524;Dbxref=dbSNP:rs371675217,PMID:7663524
SHCBP1	Q8NEM2	230	307	2	672	Chain	ID=PRO_0000076315;Note=SHC SH2 domain-binding protein 1
SHCBP1	Q8NEM2	199	229	2	672	Chain	ID=PRO_0000076315;Note=SHC SH2 domain-binding protein 1
SHCBP1	Q8NEM2	199	229	211	216	Compositional bias	Note=Poly-Glu
SHCBP1	Q8NEM2	230	307	273	273	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SHOC2	Q9UQ13	234	280	1	582	Chain	ID=PRO_0000097737;Note=Leucine-rich repeat protein SHOC-2
SHOC2	Q9UQ13	234	280	216	237	Repeat	Note=LRR 6
SHOC2	Q9UQ13	234	280	239	260	Repeat	Note=LRR 7
SHOC2	Q9UQ13	234	280	262	283	Repeat	Note=LRR 8
SHOC2	Q9UQ13	234	280	234	279	Alternative sequence	ID=VSP_038188;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SH3YL1	Q96HL8	260	279	1	342	Chain	ID=PRO_0000341560;Note=SH3 domain-containing YSC84-like protein 1
SH3YL1	Q96HL8	135	177	1	342	Chain	ID=PRO_0000341560;Note=SH3 domain-containing YSC84-like protein 1
SH3YL1	Q96HL8	37	75	1	342	Chain	ID=PRO_0000341560;Note=SH3 domain-containing YSC84-like protein 1
SH3YL1	Q96HL8	260	279	1	342	Chain	ID=PRO_0000341560;Note=SH3 domain-containing YSC84-like protein 1
SH3YL1	Q96HL8	135	177	1	342	Chain	ID=PRO_0000341560;Note=SH3 domain-containing YSC84-like protein 1
SH3YL1	Q96HL8	37	75	1	342	Chain	ID=PRO_0000341560;Note=SH3 domain-containing YSC84-like protein 1
SH3YL1	Q96HL8	37	75	1	96	Alternative sequence	ID=VSP_034332;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
SH3YL1	Q96HL8	37	75	1	96	Alternative sequence	ID=VSP_034332;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
SH3YL1	Q96HL8	260	279	98	342	Alternative sequence	ID=VSP_034334;Note=In isoform 5. VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN->THLQLHIPSEHCPGCLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3YL1	Q96HL8	135	177	98	342	Alternative sequence	ID=VSP_034334;Note=In isoform 5. VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN->THLQLHIPSEHCPGCLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3YL1	Q96HL8	260	279	98	342	Alternative sequence	ID=VSP_034334;Note=In isoform 5. VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN->THLQLHIPSEHCPGCLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3YL1	Q96HL8	135	177	98	342	Alternative sequence	ID=VSP_034334;Note=In isoform 5. VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN->THLQLHIPSEHCPGCLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3YL1	Q96HL8	260	279	262	280	Alternative sequence	ID=VSP_034335;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
SH3YL1	Q96HL8	260	279	262	280	Alternative sequence	ID=VSP_034335;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
SH3YL1	Q96HL8	135	177	141	141	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3YL1	Q96HL8	135	177	141	141	Sequence conflict	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHROOM2	Q13796	106	149	1	1616	Chain	ID=PRO_0000064650;Note=Protein Shroom2
SHROOM2	Q13796	1196	1379	1	1616	Chain	ID=PRO_0000064650;Note=Protein Shroom2
SHROOM2	Q13796	1437	1528	1	1616	Chain	ID=PRO_0000064650;Note=Protein Shroom2
SHROOM2	Q13796	106	149	26	108	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
SHROOM2	Q13796	1196	1379	1317	1611	Domain	Note=ASD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00638
SHROOM2	Q13796	1437	1528	1317	1611	Domain	Note=ASD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00638
SHROOM2	Q13796	1196	1379	1297	1297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2ALU4
SHROOM2	Q13796	1196	1379	1245	1245	Natural variant	ID=VAR_036577;Note=In a breast cancer sample%3B somatic mutation. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1033602309,PMID:16959974
SHROOM2	Q13796	1437	1528	1475	1475	Natural variant	ID=VAR_053897;Note=I->V;Dbxref=dbSNP:rs12012202
SHROOM2	Q13796	1437	1528	1438	1479	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F4Y
SHROOM2	Q13796	1437	1528	1482	1519	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F4Y
SHROOM2	Q13796	1437	1528	1527	1564	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F4Y
SH2D1B	O14796	66	121	1	132	Chain	ID=PRO_0000097724;Note=SH2 domain-containing protein 1B
SH2D1B	O14796	66	121	5	101	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
SH2D1B	O14796	66	121	67	121	Alternative sequence	ID=VSP_010341;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH2D1B	O14796	66	121	74	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KAZ
SH2D1B	O14796	66	121	79	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KAZ
SH2D1B	O14796	66	121	88	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KAZ
SHISA4	Q96DD7	126	182	28	197	Chain	ID=PRO_0000254090;Note=Protein shisa-4
SHISA4	Q96DD7	126	182	109	197	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SHISA4	Q96DD7	126	182	131	195	Compositional bias	Note=Pro-rich
SHISA4	Q96DD7	126	182	159	159	Natural variant	ID=VAR_028811;Note=I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12975309,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2250377,PMID:12975309,PMID:14702039,PMID:15489334
ST3GAL1	Q11201	243	283	1	340	Chain	ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1
ST3GAL1	Q11201	243	283	1	340	Chain	ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1
ST3GAL1	Q11201	243	283	1	340	Chain	ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1
ST3GAL1	Q11201	243	283	35	340	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL1	Q11201	243	283	35	340	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL1	Q11201	243	283	35	340	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL1	Q11201	243	283	266	266	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	266	266	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	266	266	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	270	270	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	270	270	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	270	270	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	142	281	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	142	281	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL1	Q11201	243	283	142	281	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL6	Q9Y274	112	143	1	331	Chain	ID=PRO_0000149305;Note=Type 2 lactosamine alpha-2%2C3-sialyltransferase
ST3GAL6	Q9Y274	252	303	1	331	Chain	ID=PRO_0000149305;Note=Type 2 lactosamine alpha-2%2C3-sialyltransferase
ST3GAL6	Q9Y274	112	143	1	331	Chain	ID=PRO_0000149305;Note=Type 2 lactosamine alpha-2%2C3-sialyltransferase
ST3GAL6	Q9Y274	252	303	1	331	Chain	ID=PRO_0000149305;Note=Type 2 lactosamine alpha-2%2C3-sialyltransferase
ST3GAL6	Q9Y274	112	143	26	331	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	252	303	26	331	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	112	143	26	331	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	252	303	26	331	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	112	143	129	129	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	112	143	129	129	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	252	303	282	282	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	252	303	282	282	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	252	303	295	295	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	252	303	295	295	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL6	Q9Y274	112	143	112	144	Alternative sequence	ID=VSP_047010;Note=In isoform 2. NIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIR->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ST3GAL6	Q9Y274	112	143	112	144	Alternative sequence	ID=VSP_047010;Note=In isoform 2. NIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIR->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ST3GAL6	Q9Y274	252	303	271	271	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ST3GAL6	Q9Y274	252	303	271	271	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ST3GAL4	Q11206	34	60	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	114	145	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	209	257	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	34	60	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	114	145	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	209	257	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	34	60	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	114	145	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	209	257	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	34	60	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	114	145	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	209	257	1	333	Chain	ID=PRO_0000149262;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 4
ST3GAL4	Q11206	34	60	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	209	257	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	34	60	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	209	257	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	34	60	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	209	257	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	34	60	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	209	257	27	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	131	131	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL4	Q11206	114	145	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	209	257	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	114	145	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	209	257	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	114	145	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	209	257	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	114	145	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	209	257	120	273	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL4	Q11206	34	60	30	34	Alternative sequence	ID=VSP_021104;Note=In isoform 5%2C isoform 6 and isoform 7. RYIEL->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12441665,ECO:0000303|PubMed:7901202;Dbxref=PMID:12441665,PMID:7901202
ST3GAL4	Q11206	34	60	30	34	Alternative sequence	ID=VSP_021104;Note=In isoform 5%2C isoform 6 and isoform 7. RYIEL->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12441665,ECO:0000303|PubMed:7901202;Dbxref=PMID:12441665,PMID:7901202
ST3GAL4	Q11206	34	60	30	34	Alternative sequence	ID=VSP_021104;Note=In isoform 5%2C isoform 6 and isoform 7. RYIEL->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12441665,ECO:0000303|PubMed:7901202;Dbxref=PMID:12441665,PMID:7901202
ST3GAL4	Q11206	34	60	30	34	Alternative sequence	ID=VSP_021104;Note=In isoform 5%2C isoform 6 and isoform 7. RYIEL->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12441665,ECO:0000303|PubMed:7901202;Dbxref=PMID:12441665,PMID:7901202
ST6GALNAC1	Q9NSC7	472	501	1	600	Chain	ID=PRO_0000149269;Note=Alpha-N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 1
ST6GALNAC1	Q9NSC7	472	501	36	600	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC1	Q9NSC7	472	501	365	533	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST6GALNAC2	Q9UJ37	258	285	1	374	Chain	ID=PRO_0000149272;Note=Alpha-N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 2
ST6GALNAC2	Q9UJ37	258	285	29	374	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC2	Q9UJ37	258	285	151	317	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6APJ,ECO:0000244|PDB:6APL,ECO:0000269|PubMed:29251719;Dbxref=PMID:29251719
ST6GALNAC2	Q9UJ37	258	285	259	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6APL
ST6GALNAC2	Q9UJ37	258	285	269	271	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6APL
ST6GALNAC2	Q9UJ37	258	285	272	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6APL
ST6GALNAC2	Q9UJ37	258	285	277	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6APL
ST8SIA2	Q92186	183	280	1	375	Chain	ID=PRO_0000149285;Note=Alpha-2%2C8-sialyltransferase 8B
ST8SIA2	Q92186	183	280	24	375	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA2	Q92186	183	280	206	208	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA2	Q92186	183	280	185	185	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA2	Q92186	183	280	219	219	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA2	Q92186	183	280	234	234	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA2	Q92186	183	280	157	307	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA2	Q92186	183	280	171	371	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA6	P61647	212	242	1	398	Chain	ID=PRO_0000149299;Note=Alpha-2%2C8-sialyltransferase 8F
ST8SIA6	P61647	97	125	1	398	Chain	ID=PRO_0000149299;Note=Alpha-2%2C8-sialyltransferase 8F
ST8SIA6	P61647	67	96	1	398	Chain	ID=PRO_0000149299;Note=Alpha-2%2C8-sialyltransferase 8F
ST8SIA6	P61647	212	242	25	398	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA6	P61647	97	125	25	398	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA6	P61647	67	96	25	398	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA6	P61647	212	242	236	238	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA6	P61647	212	242	214	214	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA6	P61647	67	96	93	93	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST8SIA6	P61647	212	242	186	335	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
ST8SIA6	P61647	212	242	200	395	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43173
SIM2	Q14190	86	116	1	667	Chain	ID=PRO_0000127441;Note=Single-minded homolog 2
SIM2	Q14190	86	116	77	149	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
SIRT3	Q9NTG7	323	393	126	382	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236
SIRT3	Q9NTG7	269	323	126	382	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236
SIRT3	Q9NTG7	269	323	319	321	Nucleotide binding	Note=NAD
SIRT3	Q9NTG7	323	393	344	346	Nucleotide binding	Note=NAD
SIRT3	Q9NTG7	269	323	280	280	Metal binding	Note=Zinc
SIRT3	Q9NTG7	269	323	283	283	Metal binding	Note=Zinc
SIRT3	Q9NTG7	323	393	366	366	Binding site	Note=NAD%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIRT3	Q9NTG7	323	393	369	369	Natural variant	ID=VAR_051979;Note=G->S;Dbxref=dbSNP:rs3020901
SIRT3	Q9NTG7	269	323	265	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	269	323	281	283	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	269	323	286	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	269	323	300	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	269	323	305	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	269	323	313	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	323	393	327	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	323	393	331	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C7B
SIRT3	Q9NTG7	323	393	340	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	323	393	349	353	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	323	393	359	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	323	393	366	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SIRT3	Q9NTG7	323	393	380	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BN4
SOX30	O94993	402	462	1	753	Chain	ID=PRO_0000048773;Note=Transcription factor SOX-30
SOX30	O94993	322	402	1	753	Chain	ID=PRO_0000048773;Note=Transcription factor SOX-30
SOX30	O94993	402	462	337	405	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
SOX30	O94993	322	402	337	405	DNA binding	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
SOX30	O94993	402	462	429	429	Natural variant	ID=VAR_049563;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12188040,PMID:15489334
SP110	Q9HB58	605	652	1	689	Chain	ID=PRO_0000074101;Note=Sp110 nuclear body protein
SP110	Q9HB58	376	426	1	689	Chain	ID=PRO_0000074101;Note=Sp110 nuclear body protein
SP110	Q9HB58	299	349	1	689	Chain	ID=PRO_0000074101;Note=Sp110 nuclear body protein
SP110	Q9HB58	605	652	581	676	Domain	Note=Bromo
SP110	Q9HB58	376	426	380	380	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SP110	Q9HB58	299	349	300	349	Alternative sequence	ID=VSP_005995;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7693701;Dbxref=PMID:7693701
SP110	Q9HB58	299	349	300	303	Alternative sequence	ID=VSP_005996;Note=In isoform 5. GTAS->AL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SP110	Q9HB58	605	652	550	689	Alternative sequence	ID=VSP_006000;Note=In isoform 3%2C isoform 4%2C isoform 5 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10913195,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7693701;Dbxref=PMID:10913195,PMID:14702039,PMID:15489334,PMID:7693701
SP110	Q9HB58	605	652	605	605	Alternative sequence	ID=VSP_035593;Note=In isoform 6. L->LKCEFLLLKAYCHPQSSFFTGIPFN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SP110	Q9HB58	605	652	606	611	Alternative sequence	ID=VSP_006001;Note=In isoform 2. IRDYGE->NVSSSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7693701;Dbxref=PMID:7693701
SP110	Q9HB58	605	652	612	689	Alternative sequence	ID=VSP_006002;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7693701;Dbxref=PMID:7693701
SP110	Q9HB58	299	349	299	299	Natural variant	ID=VAR_027177;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10913195,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16803959,ECO:0000269|PubMed:16816019,ECO:0000269|PubMed:7693701;Dbxref=dbSNP:rs1365776,PMID:10913195,PMID:14702039,PMID:15489334,PMID:16803959,PMID:16816019,PMID:7693701
SP110	Q9HB58	376	426	425	425	Natural variant	ID=VAR_027179;Note=Polymorphism%3B may be associated with increased susceptibility to tuberculosis. L->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16803959,ECO:0000269|PubMed:16816019;Dbxref=dbSNP:rs3948464,PMID:14702039,PMID:16803959,PMID:16816019
SNX19	Q92543	638	678	1	992	Chain	ID=PRO_0000213868;Note=Sorting nexin-19
SNX19	Q92543	638	678	533	663	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SERPINB7	O75635	56	73	1	380	Chain	ID=PRO_0000094108;Note=Serpin B7
SERPINB7	O75635	73	112	1	380	Chain	ID=PRO_0000094108;Note=Serpin B7
SERPINB7	O75635	56	73	1	380	Chain	ID=PRO_0000094108;Note=Serpin B7
SERPINB7	O75635	73	112	1	380	Chain	ID=PRO_0000094108;Note=Serpin B7
SERPINB7	O75635	56	73	1	380	Chain	ID=PRO_0000094108;Note=Serpin B7
SERPINB7	O75635	73	112	1	380	Chain	ID=PRO_0000094108;Note=Serpin B7
SERPINB7	O75635	56	73	57	73	Alternative sequence	ID=VSP_044711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERPINB7	O75635	73	112	57	73	Alternative sequence	ID=VSP_044711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERPINB7	O75635	56	73	57	73	Alternative sequence	ID=VSP_044711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERPINB7	O75635	73	112	57	73	Alternative sequence	ID=VSP_044711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERPINB7	O75635	56	73	57	73	Alternative sequence	ID=VSP_044711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SERPINB7	O75635	73	112	57	73	Alternative sequence	ID=VSP_044711;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPATA6	Q9NWH7	135	162	21	488	Chain	ID=PRO_0000278441;Note=Spermatogenesis-associated protein 6
SPATA6	Q9NWH7	79	93	21	488	Chain	ID=PRO_0000278441;Note=Spermatogenesis-associated protein 6
SPAST	Q9UBP0	195	227	1	616	Chain	ID=PRO_0000084763;Note=Spastin
SPAST	Q9UBP0	366	391	1	616	Chain	ID=PRO_0000084763;Note=Spastin
SPAST	Q9UBP0	391	415	1	616	Chain	ID=PRO_0000084763;Note=Spastin
SPAST	Q9UBP0	195	227	78	616	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|HAMAP-Rule:MF_03021,ECO:0000305|PubMed:20200447;Dbxref=PMID:20200447
SPAST	Q9UBP0	366	391	78	616	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|HAMAP-Rule:MF_03021,ECO:0000305|PubMed:20200447;Dbxref=PMID:20200447
SPAST	Q9UBP0	391	415	78	616	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|HAMAP-Rule:MF_03021,ECO:0000305|PubMed:20200447;Dbxref=PMID:20200447
SPAST	Q9UBP0	195	227	120	195	Domain	Note=MIT;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPAST	Q9UBP0	366	391	382	389	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|HAMAP-Rule:MF_03021,ECO:0000305|PubMed:15716377;Dbxref=PMID:15716377
SPAST	Q9UBP0	195	227	1	300	Region	Note=Required for interaction with RTN1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16602018;Dbxref=PMID:16602018
SPAST	Q9UBP0	195	227	112	196	Region	Note=Sufficient for interaction with CHMP1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18997780;Dbxref=PMID:18997780
SPAST	Q9UBP0	195	227	114	200	Region	Note=Required for interaction with microtubules;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15269182;Dbxref=PMID:15269182
SPAST	Q9UBP0	366	391	228	616	Region	Note=Sufficient for microtubule severing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15269182;Dbxref=PMID:15269182
SPAST	Q9UBP0	391	415	228	616	Region	Note=Sufficient for microtubule severing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15269182;Dbxref=PMID:15269182
SPAST	Q9UBP0	195	227	197	228	Alternative sequence	ID=VSP_000024;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
SPAST	Q9UBP0	195	227	44	616	Natural variant	ID=VAR_075827;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	366	391	44	616	Natural variant	ID=VAR_075827;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	391	415	44	616	Natural variant	ID=VAR_075827;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	195	227	112	616	Natural variant	ID=VAR_075829;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	366	391	112	616	Natural variant	ID=VAR_075829;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	391	415	112	616	Natural variant	ID=VAR_075829;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	195	227	135	616	Natural variant	ID=VAR_075830;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	366	391	135	616	Natural variant	ID=VAR_075830;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	391	415	135	616	Natural variant	ID=VAR_075830;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	195	227	195	195	Natural variant	ID=VAR_026758;Note=In SPG4. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16682546;Dbxref=PMID:16682546
SPAST	Q9UBP0	195	227	201	201	Natural variant	ID=VAR_067629;Note=In SPG4%3B unknown pathological significance. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20718791;Dbxref=PMID:20718791
SPAST	Q9UBP0	366	391	244	616	Natural variant	ID=VAR_075831;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25421405;Dbxref=PMID:25421405
SPAST	Q9UBP0	391	415	244	616	Natural variant	ID=VAR_075831;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25421405;Dbxref=PMID:25421405
SPAST	Q9UBP0	366	391	245	616	Natural variant	ID=VAR_075832;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	391	415	245	616	Natural variant	ID=VAR_075832;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	366	391	254	616	Natural variant	ID=VAR_075833;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	391	415	254	616	Natural variant	ID=VAR_075833;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	366	391	366	366	Natural variant	ID=VAR_079315;Note=In SPG4%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28572275;Dbxref=PMID:28572275
SPAST	Q9UBP0	366	391	368	368	Natural variant	ID=VAR_075837;Note=In SPG4. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21546041,ECO:0000269|PubMed:28572275;Dbxref=PMID:21546041,PMID:28572275
SPAST	Q9UBP0	366	391	368	368	Natural variant	ID=VAR_079316;Note=In SPG4%3B unknown pathological significance. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28572275;Dbxref=PMID:28572275
SPAST	Q9UBP0	366	391	370	370	Natural variant	ID=VAR_027208;Note=In SPG4%3B promotes microtubule binding and the formation of thick microtubule bundles. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10699187,ECO:0000269|PubMed:11809724;Dbxref=PMID:10699187,PMID:11809724
SPAST	Q9UBP0	366	391	372	372	Natural variant	ID=VAR_075838;Note=In SPG4. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25045380;Dbxref=PMID:25045380
SPAST	Q9UBP0	366	391	372	372	Natural variant	ID=VAR_079317;Note=In SPG4%3B unknown pathological significance. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28572275;Dbxref=PMID:28572275
SPAST	Q9UBP0	366	391	377	377	Natural variant	ID=VAR_075839;Note=In SPG4. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21546041;Dbxref=PMID:21546041
SPAST	Q9UBP0	366	391	378	378	Natural variant	ID=VAR_019439;Note=In SPG4. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14732620;Dbxref=PMID:14732620
SPAST	Q9UBP0	366	391	378	378	Natural variant	ID=VAR_067637;Note=In SPG4. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
SPAST	Q9UBP0	366	391	380	380	Natural variant	ID=VAR_067638;Note=In SPG4. L->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17594340,ECO:0000269|PubMed:20932283;Dbxref=PMID:17594340,PMID:20932283
SPAST	Q9UBP0	366	391	381	381	Natural variant	ID=VAR_027209;Note=In SPG4%3B promotes microtubule binding and the formation of thick microtubule bundles. F->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10699187,ECO:0000269|PubMed:11809724;Dbxref=PMID:10699187,PMID:11809724
SPAST	Q9UBP0	366	391	382	382	Natural variant	ID=VAR_067566;Note=In SPG4%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20562464;Dbxref=PMID:20562464
SPAST	Q9UBP0	366	391	386	386	Natural variant	ID=VAR_027210;Note=In SPG4%3B abrogates ATPase activity%2C promotes microtubule binding and the formation of thick microtubule bundles. N->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10699187,ECO:0000269|PubMed:11809724,ECO:0000269|PubMed:15716377;Dbxref=PMID:10699187,PMID:11809724,PMID:15716377
SPAST	Q9UBP0	366	391	386	386	Natural variant	ID=VAR_019440;Note=In SPG4. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15210521;Dbxref=dbSNP:rs121908514,PMID:15210521
SPAST	Q9UBP0	366	391	386	386	Natural variant	ID=VAR_079318;Note=In SPG4%3B unknown pathological significance. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28572275;Dbxref=PMID:28572275
SPAST	Q9UBP0	366	391	388	388	Natural variant	ID=VAR_027211;Note=In SPG4%3B abrogates ATPase activity%2C promotes microtubule binding and the formation of thick microtubule bundles and impairs traffic from the ER to Golgi. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10699187,ECO:0000269|PubMed:11809724,ECO:0000269|PubMed:12161613,ECO:0000269|PubMed:15716377,ECO:0000269|PubMed:15891913,ECO:0000269|PubMed:16339213,ECO:0000269|PubMed:19000169;Dbxref=PMID:10699187,PMID:11809724,PMID:12161613,PMID:15716377,PMID:15891913,PMID:16339213,PMID:19000169
SPAST	Q9UBP0	366	391	390	390	Natural variant	ID=VAR_079319;Note=In SPG4%3B unknown pathological significance. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28572275;Dbxref=dbSNP:rs1131691977,PMID:28572275
SPAST	Q9UBP0	366	391	390	390	Natural variant	ID=VAR_019441;Note=In SPG4. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14732620;Dbxref=dbSNP:rs797044850,PMID:14732620
SPAST	Q9UBP0	366	391	391	391	Natural variant	ID=VAR_067639;Note=In SPG4. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
SPAST	Q9UBP0	391	415	391	391	Natural variant	ID=VAR_067639;Note=In SPG4. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
SPAST	Q9UBP0	391	415	393	396	Natural variant	ID=VAR_067640;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
SPAST	Q9UBP0	391	415	399	399	Natural variant	ID=VAR_027212;Note=In SPG4. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11843700,ECO:0000269|PubMed:22960362,ECO:0000269|PubMed:24824479,ECO:0000269|PubMed:25045380;Dbxref=PMID:11843700,PMID:22960362,PMID:24824479,PMID:25045380
SPAST	Q9UBP0	391	415	404	404	Natural variant	ID=VAR_019449;Note=In SPG4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12163196;Dbxref=PMID:12163196
SPAST	Q9UBP0	391	415	406	406	Natural variant	ID=VAR_075840;Note=In SPG4. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22960362;Dbxref=PMID:22960362
SPAST	Q9UBP0	391	415	406	406	Natural variant	ID=VAR_026759;Note=In SPG4. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16682546;Dbxref=dbSNP:rs587777757,PMID:16682546
SPAST	Q9UBP0	391	415	407	407	Natural variant	ID=VAR_067567;Note=In SPG4%3B unknown pathological significance. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20562464;Dbxref=PMID:20562464
SPAST	Q9UBP0	391	415	407	407	Natural variant	ID=VAR_019450;Note=In SPG4. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12124993;Dbxref=PMID:12124993
SPAST	Q9UBP0	391	415	409	409	Natural variant	ID=VAR_067641;Note=In SPG4. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20932283,ECO:0000269|PubMed:22960362;Dbxref=dbSNP:rs1064793273,PMID:20932283,PMID:22960362
SPAST	Q9UBP0	391	415	410	410	Natural variant	ID=VAR_067642;Note=In SPG4. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20932283;Dbxref=PMID:20932283
SPAST	Q9UBP0	391	415	413	413	Natural variant	ID=VAR_067568;Note=In SPG4. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20550563;Dbxref=PMID:20550563
SPAST	Q9UBP0	366	391	388	388	Mutagenesis	Note=Abrogates ATPase activity and abolishes microtubule severing. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15716377;Dbxref=PMID:15716377
SPAST	Q9UBP0	391	415	415	415	Mutagenesis	Note=Abrogates binding to the tail of alpha-tubulin and beta-3-tubulin%2C impairs ATPase activity and abolishes microtubule severing. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17389232;Dbxref=PMID:17389232
SPAST	Q9UBP0	195	227	169	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EAB
SPAST	Q9UBP0	366	391	365	367	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VFD
SPAST	Q9UBP0	366	391	370	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VFD
SPAST	Q9UBP0	366	391	376	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VFD
SPAST	Q9UBP0	366	391	388	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VFD
SPAST	Q9UBP0	391	415	388	398	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VFD
SPAST	Q9UBP0	391	415	402	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VFD
TRMT10B	Q6PF06	140	191	1	316	Chain	ID=PRO_0000311321;Note=tRNA methyltransferase 10 homolog B
TRMT10B	Q6PF06	140	191	113	310	Domain	Note=SAM-dependent MTase TRM10-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01012
TRMT10B	Q6PF06	140	191	63	140	Alternative sequence	ID=VSP_054652;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRMT10B	Q6PF06	140	191	141	191	Alternative sequence	ID=VSP_055735;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRMT10B	Q6PF06	140	191	141	174	Alternative sequence	ID=VSP_029520;Note=In isoform 3. ELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDS->VEHPLSLEFLLAMREAQKGTAFRRIWSTPASGIP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRMT10B	Q6PF06	140	191	175	316	Alternative sequence	ID=VSP_029521;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPDEF	O95238	227	276	1	335	Chain	ID=PRO_0000223958;Note=SAM pointed domain-containing Ets transcription factor
SPDEF	O95238	211	227	1	335	Chain	ID=PRO_0000223958;Note=SAM pointed domain-containing Ets transcription factor
SPDEF	O95238	145	211	1	335	Chain	ID=PRO_0000223958;Note=SAM pointed domain-containing Ets transcription factor
SPDEF	O95238	211	227	129	213	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
SPDEF	O95238	145	211	129	213	Domain	Note=PNT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00762
SPDEF	O95238	227	276	249	332	DNA binding	Note=ETS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00237
SPDEF	O95238	227	276	212	227	Alternative sequence	ID=VSP_044722;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPDEF	O95238	211	227	212	227	Alternative sequence	ID=VSP_044722;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPDEF	O95238	145	211	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	145	211	155	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	145	211	172	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	145	211	180	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	145	211	188	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	145	211	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	211	227	200	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	145	211	200	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKX
SPDEF	O95238	227	276	251	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YO5
SPDEF	O95238	227	276	262	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YO5
SPDEF	O95238	227	276	266	268	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YO5
SPDEF	O95238	227	276	269	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YO5
SPDEF	O95238	227	276	274	277	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YO5
TMEM143	Q96AN5	123	188	1	459	Chain	ID=PRO_0000285958;Note=Transmembrane protein 143
TMEM143	Q96AN5	88	123	1	459	Chain	ID=PRO_0000285958;Note=Transmembrane protein 143
TMEM143	Q96AN5	123	188	88	187	Alternative sequence	ID=VSP_024930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:12975309,PMID:14702039
TMEM143	Q96AN5	88	123	88	187	Alternative sequence	ID=VSP_024930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:12975309,PMID:14702039
TMEM143	Q96AN5	123	188	89	128	Alternative sequence	ID=VSP_024931;Note=In isoform 3. EFHSSPAEKAALEAFSAHVDFCTLFHYHQILARLQALYDP->VTGIPLESGREGGFGGVLSPRGLLHPVPLPPNPGPAAGLI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM143	Q96AN5	88	123	89	128	Alternative sequence	ID=VSP_024931;Note=In isoform 3. EFHSSPAEKAALEAFSAHVDFCTLFHYHQILARLQALYDP->VTGIPLESGREGGFGGVLSPRGLLHPVPLPPNPGPAAGLI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM143	Q96AN5	123	188	129	459	Alternative sequence	ID=VSP_024932;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM143	Q96AN5	123	188	143	143	Natural variant	ID=VAR_032058;Note=D->N;Dbxref=dbSNP:rs34488893
TMEM201	Q5SNT2	464	488	1	666	Chain	ID=PRO_0000317198;Note=Transmembrane protein 201
TMEM201	Q5SNT2	488	588	1	666	Chain	ID=PRO_0000317198;Note=Transmembrane protein 201
TMEM201	Q5SNT2	464	488	375	644	Topological domain	Note=Nuclear;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305,ECO:0000305|PubMed:19494128;Dbxref=PMID:19494128
TMEM201	Q5SNT2	488	588	375	644	Topological domain	Note=Nuclear;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305,ECO:0000305|PubMed:19494128;Dbxref=PMID:19494128
TMEM201	Q5SNT2	464	488	441	520	Compositional bias	Note=Ser-rich
TMEM201	Q5SNT2	488	588	441	520	Compositional bias	Note=Ser-rich
TMEM201	Q5SNT2	464	488	466	466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMEM201	Q5SNT2	464	488	477	477	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMEM201	Q5SNT2	464	488	480	480	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TMEM201	Q5SNT2	488	588	529	529	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
TMEM201	Q5SNT2	464	488	393	666	Alternative sequence	ID=VSP_030916;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM201	Q5SNT2	488	588	393	666	Alternative sequence	ID=VSP_030916;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM202	A6NGA9	162	206	1	273	Chain	ID=PRO_0000317201;Note=Transmembrane protein 202
TMEM202	A6NGA9	162	206	155	175	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM202	A6NGA9	162	206	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM202	A6NGA9	162	206	204	204	Natural variant	ID=VAR_051434;Note=M->L;Dbxref=dbSNP:rs16956904
SPAG16	Q8N0X2	179	214	1	631	Chain	ID=PRO_0000051223;Note=Sperm-associated antigen 16 protein
SPAG16	Q8N0X2	405	466	1	631	Chain	ID=PRO_0000051223;Note=Sperm-associated antigen 16 protein
SPAG16	Q8N0X2	509	531	1	631	Chain	ID=PRO_0000051223;Note=Sperm-associated antigen 16 protein
SPAG16	Q8N0X2	405	466	392	431	Repeat	Note=WD 2
SPAG16	Q8N0X2	405	466	434	473	Repeat	Note=WD 3
SPAG16	Q8N0X2	509	531	476	515	Repeat	Note=WD 4
SPAG16	Q8N0X2	509	531	518	557	Repeat	Note=WD 5
SPAG16	Q8N0X2	179	214	152	267	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPAG16	Q8N0X2	179	214	150	179	Alternative sequence	ID=VSP_013495;Note=In isoform 2. VPDVYTQIMLLENENKNLKKDLKHYKQAAD->MTILASQKVKKIWQKQFRWPKNRLQILKFC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SPAG16	Q8N0X2	179	214	179	183	Alternative sequence	ID=VSP_013496;Note=In isoform 4. DKARE->EYVIF;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11867345,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:11867345,PMID:14702039,PMID:15489334
SPAG16	Q8N0X2	179	214	184	631	Alternative sequence	ID=VSP_013497;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11867345,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:11867345,PMID:14702039,PMID:15489334
SPAG16	Q8N0X2	405	466	184	631	Alternative sequence	ID=VSP_013497;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11867345,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:11867345,PMID:14702039,PMID:15489334
SPAG16	Q8N0X2	509	531	184	631	Alternative sequence	ID=VSP_013497;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11867345,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:11867345,PMID:14702039,PMID:15489334
SPAG16	Q8N0X2	405	466	283	631	Alternative sequence	ID=VSP_013499;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPAG16	Q8N0X2	509	531	283	631	Alternative sequence	ID=VSP_013499;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPAG16	Q8N0X2	405	466	348	631	Alternative sequence	ID=VSP_013501;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SPAG16	Q8N0X2	509	531	348	631	Alternative sequence	ID=VSP_013501;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SPAG16	Q8N0X2	405	466	425	425	Natural variant	ID=VAR_022367;Note=K->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11867345,ECO:0000269|PubMed:12391165;Dbxref=dbSNP:rs12623569,PMID:11867345,PMID:12391165
TMEM206	Q9H813	261	297	1	350	Chain	ID=PRO_0000279471;Note=Transmembrane protein 206
TMEM206	Q9H813	44	114	1	350	Chain	ID=PRO_0000279471;Note=Transmembrane protein 206
TMEM206	Q9H813	44	114	1	64	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM206	Q9H813	44	114	65	85	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM206	Q9H813	261	297	86	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM206	Q9H813	44	114	86	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM206	Q9H813	44	114	47	47	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM220	Q6QAJ8	96	115	1	160	Chain	ID=PRO_0000319424;Note=Transmembrane protein 220
TMEM220	Q6QAJ8	24	34	1	160	Chain	ID=PRO_0000319424;Note=Transmembrane protein 220
TMEM220	Q6QAJ8	24	34	30	50	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM220	Q6QAJ8	96	115	100	120	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM220	Q6QAJ8	24	34	25	34	Alternative sequence	ID=VSP_031477;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SPHKAP	Q2M3C7	1545	1573	1	1700	Chain	ID=PRO_0000320666;Note=A-kinase anchor protein SPHKAP
SPHKAP	Q2M3C7	46	82	1	1700	Chain	ID=PRO_0000320666;Note=A-kinase anchor protein SPHKAP
SPHKAP	Q2M3C7	1545	1573	1546	1574	Alternative sequence	ID=VSP_031712;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:17974005;Dbxref=PMID:11214970,PMID:17974005
SPIRE1	Q08AE8	546	592	2	756	Chain	ID=PRO_0000309569;Note=Protein spire homolog 1
SPIRE1	Q08AE8	396	410	2	756	Chain	ID=PRO_0000309569;Note=Protein spire homolog 1
SPIRE1	Q08AE8	324	353	2	756	Chain	ID=PRO_0000309569;Note=Protein spire homolog 1
SPIRE1	Q08AE8	269	324	2	756	Chain	ID=PRO_0000309569;Note=Protein spire homolog 1
SPIRE1	Q08AE8	243	269	2	756	Chain	ID=PRO_0000309569;Note=Protein spire homolog 1
SPIRE1	Q08AE8	124	201	2	756	Chain	ID=PRO_0000309569;Note=Protein spire homolog 1
SPIRE1	Q08AE8	124	201	40	231	Domain	Note=KIND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00709
SPIRE1	Q08AE8	269	324	305	323	Domain	Note=WH2 1
SPIRE1	Q08AE8	124	201	131	138	Region	Note=Important for interaction with FMN2
SPIRE1	Q08AE8	546	592	556	576	Region	Note=Spir-box
SPIRE1	Q08AE8	243	269	229	257	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPIRE1	Q08AE8	396	410	406	406	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q52KF3
SPIRE1	Q08AE8	124	201	1	159	Alternative sequence	ID=VSP_037925;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
SPIRE1	Q08AE8	396	410	397	410	Alternative sequence	ID=VSP_052595;Note=In isoform 2%2C isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11747823,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:11747823,PMID:14702039,PMID:15489334,PMID:17974005
SPIRE1	Q08AE8	243	269	249	249	Natural variant	ID=VAR_058695;Note=Q->P;Dbxref=dbSNP:rs1785296
SPIRE1	Q08AE8	124	201	131	131	Mutagenesis	Note=Strongly reduces interaction with FMN2. I->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21730168;Dbxref=PMID:21730168
SPIRE1	Q08AE8	124	201	134	134	Mutagenesis	Note=Abolishes interaction with FMN2. Y->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21705804;Dbxref=PMID:21705804
SPIRE1	Q08AE8	124	201	138	138	Mutagenesis	Note=Abolishes interaction with FMN2. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21705804,ECO:0000269|PubMed:21730168;Dbxref=PMID:21705804,PMID:21730168
SPIRE1	Q08AE8	124	201	146	146	Mutagenesis	Note=Abolishes interaction with FMN2. E->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21730168;Dbxref=PMID:21730168
SPIRE1	Q08AE8	124	201	122	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YLE
SPIRE1	Q08AE8	124	201	138	140	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YLE
SPIRE1	Q08AE8	124	201	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YLE
SPIRE1	Q08AE8	124	201	151	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YLE
SPIRE1	Q08AE8	124	201	196	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YLE
TMEM230	Q96A57	33	74	1	120	Chain	ID=PRO_0000233892;Note=Transmembrane protein 230
TMEM230	Q96A57	33	74	1	120	Chain	ID=PRO_0000233892;Note=Transmembrane protein 230
TMEM230	Q96A57	33	74	1	120	Chain	ID=PRO_0000233892;Note=Transmembrane protein 230
TMEM230	Q96A57	33	74	1	120	Chain	ID=PRO_0000233892;Note=Transmembrane protein 230
TMEM230	Q96A57	33	74	1	120	Chain	ID=PRO_0000233892;Note=Transmembrane protein 230
TMEM230	Q96A57	33	74	46	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM230	Q96A57	33	74	46	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM230	Q96A57	33	74	46	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM230	Q96A57	33	74	46	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM230	Q96A57	33	74	46	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM230	Q96A57	33	74	59	61	Sequence conflict	Note=LII->SY;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM230	Q96A57	33	74	59	61	Sequence conflict	Note=LII->SY;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM230	Q96A57	33	74	59	61	Sequence conflict	Note=LII->SY;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM230	Q96A57	33	74	59	61	Sequence conflict	Note=LII->SY;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM230	Q96A57	33	74	59	61	Sequence conflict	Note=LII->SY;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPINT1	O43278	247	320	36	529	Chain	ID=PRO_0000016883;Note=Kunitz-type protease inhibitor 1
SPINT1	O43278	329	371	36	529	Chain	ID=PRO_0000016883;Note=Kunitz-type protease inhibitor 1
SPINT1	O43278	445	461	36	529	Chain	ID=PRO_0000016883;Note=Kunitz-type protease inhibitor 1
SPINT1	O43278	247	320	250	300	Domain	Note=BPTI/Kunitz inhibitor 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
SPINT1	O43278	329	371	334	370	Domain	Note=LDL-receptor class A;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SPINT1	O43278	247	320	260	261	Site	Note=Reactive bond;Ontology_term=ECO:0000250;evidence=ECO:0000250
SPINT1	O43278	247	320	250	300	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713485;Dbxref=PMID:15713485
SPINT1	O43278	247	320	259	283	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713485;Dbxref=PMID:15713485
SPINT1	O43278	247	320	275	296	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713485;Dbxref=PMID:15713485
SPINT1	O43278	329	371	335	347	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPINT1	O43278	329	371	342	360	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPINT1	O43278	329	371	354	369	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPINT1	O43278	247	320	306	321	Alternative sequence	ID=VSP_013019;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9045658;Dbxref=PMID:15489334,PMID:9045658
SPINT1	O43278	329	371	337	337	Natural variant	ID=VAR_050067;Note=P->L;Dbxref=dbSNP:rs7165897
SPINT1	O43278	247	320	246	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
SPINT1	O43278	247	320	263	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
SPINT1	O43278	247	320	270	272	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
SPINT1	O43278	247	320	273	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
SPINT1	O43278	247	320	282	284	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
SPINT1	O43278	247	320	290	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
SPINT1	O43278	247	320	293	300	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ISO
TMEM231	Q9H6L2	146	194	1	316	Chain	ID=PRO_0000317520;Note=Transmembrane protein 231
TMEM231	Q9H6L2	146	194	194	194	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM235	A6NFC5	63	90	29	223	Chain	ID=PRO_0000406902;Note=Transmembrane protein 235
TMEM235	A6NFC5	63	90	64	91	Alternative sequence	ID=VSP_040887;Note=In isoform 2. GQNGCIPLVDPFASESLDVSTSVQHLIL->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM235	A6NFC5	63	90	65	137	Alternative sequence	ID=VSP_040888;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM59L	Q9UK28	136	187	25	342	Chain	ID=PRO_0000003000;Note=Transmembrane protein 59-like
TMEM59L	Q9UK28	136	187	25	342	Chain	ID=PRO_0000003000;Note=Transmembrane protein 59-like
SPOCD1	Q6ZMY3	895	925	1	1216	Chain	ID=PRO_0000287472;Note=SPOC domain-containing protein 1
SPOCD1	Q6ZMY3	715	757	1	1216	Chain	ID=PRO_0000287472;Note=SPOC domain-containing protein 1
SPOCD1	Q6ZMY3	475	534	1	1216	Chain	ID=PRO_0000287472;Note=SPOC domain-containing protein 1
SPOCD1	Q6ZMY3	461	475	1	1216	Chain	ID=PRO_0000287472;Note=SPOC domain-containing protein 1
SPOCD1	Q6ZMY3	715	757	608	728	Domain	Note=TFIIS central;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00651
SPOCD1	Q6ZMY3	895	925	867	970	Domain	Note=SPOC
SPOCD1	Q6ZMY3	475	534	1	656	Alternative sequence	ID=VSP_025489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	461	475	1	656	Alternative sequence	ID=VSP_025489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	475	534	1	507	Alternative sequence	ID=VSP_025490;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	461	475	1	507	Alternative sequence	ID=VSP_025490;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	475	534	476	534	Alternative sequence	ID=VSP_025491;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	895	925	604	1216	Alternative sequence	ID=VSP_025493;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	715	757	604	1216	Alternative sequence	ID=VSP_025493;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCD1	Q6ZMY3	895	925	789	1216	Alternative sequence	ID=VSP_025496;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TM9SF3	Q9HD45	465	513	29	589	Chain	ID=PRO_0000034369;Note=Transmembrane 9 superfamily member 3
TM9SF3	Q9HD45	220	264	29	589	Chain	ID=PRO_0000034369;Note=Transmembrane 9 superfamily member 3
TM9SF3	Q9HD45	194	220	29	589	Chain	ID=PRO_0000034369;Note=Transmembrane 9 superfamily member 3
TM9SF3	Q9HD45	99	140	29	589	Chain	ID=PRO_0000034369;Note=Transmembrane 9 superfamily member 3
TM9SF3	Q9HD45	220	264	224	244	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF3	Q9HD45	465	513	449	469	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF3	Q9HD45	465	513	482	502	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TM9SF3	Q9HD45	194	220	210	218	Sequence conflict	Note=KYLDPSFFQ->NILIVLFS;Ontology_term=ECO:0000305;evidence=ECO:0000305
TM9SF3	Q9HD45	220	264	232	232	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPARC	P09486	19	40	18	303	Chain	ID=PRO_0000020304;Note=SPARC
SPARC	P09486	19	40	22	69	Compositional bias	Note=Asp/Glu-rich (acidic%3B binds calcium)
SPARC	P09486	19	40	19	19	Natural variant	ID=VAR_050431;Note=P->S;Dbxref=dbSNP:rs6874468
SPRED3	Q2MJR0	141	189	1	410	Chain	ID=PRO_0000247431;Note=Sprouty-related%2C EVH1 domain-containing protein 3
SPRED3	Q2MJR0	141	189	1	410	Chain	ID=PRO_0000247431;Note=Sprouty-related%2C EVH1 domain-containing protein 3
SPRED3	Q2MJR0	141	189	117	153	Compositional bias	Note=Ser-rich
SPRED3	Q2MJR0	141	189	117	153	Compositional bias	Note=Ser-rich
SPRED3	Q2MJR0	141	189	142	152	Alternative sequence	ID=VSP_042949;Note=In isoform 2. SHVDSDSSSSH->LSQYFRHMLCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641
SPRED3	Q2MJR0	141	189	142	152	Alternative sequence	ID=VSP_042949;Note=In isoform 2. SHVDSDSSSSH->LSQYFRHMLCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641
SPRED3	Q2MJR0	141	189	153	410	Alternative sequence	ID=VSP_042950;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641
SPRED3	Q2MJR0	141	189	153	410	Alternative sequence	ID=VSP_042950;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641
SUPT4H1	P63272	77	95	2	117	Chain	ID=PRO_0000210325;Note=Transcription elongation factor SPT4
SUPT4H1	P63272	77	95	2	117	Chain	ID=PRO_0000210325;Note=Transcription elongation factor SPT4
SUPT4H1	P63272	77	95	95	117	Sequence conflict	Note=QGIVRELKSRGVAYKSRDTAIKT->HAKDSRSNVNKYEPRESSEGHDTCLASLFHSLRHSNSLFAL;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUPT4H1	P63272	77	95	95	117	Sequence conflict	Note=QGIVRELKSRGVAYKSRDTAIKT->HAKDSRSNVNKYEPRESSEGHDTCLASLFHSLRHSNSLFAL;Ontology_term=ECO:0000305;evidence=ECO:0000305
SUPT4H1	P63272	77	95	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT4H1	P63272	77	95	82	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT4H1	P63272	77	95	95	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
SUPT4H1	P63272	77	95	95	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H7H
TMIGD2	Q96BF3	15	135	1	22	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
TMIGD2	Q96BF3	149	187	23	282	Chain	ID=PRO_0000275870;Note=Transmembrane and immunoglobulin domain-containing protein 2
TMIGD2	Q96BF3	15	135	23	282	Chain	ID=PRO_0000275870;Note=Transmembrane and immunoglobulin domain-containing protein 2
TMIGD2	Q96BF3	149	187	23	150	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	15	135	23	150	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	149	187	151	171	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	149	187	172	282	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	15	135	23	129	Domain	Note=Ig-like
TMIGD2	Q96BF3	15	135	73	73	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	15	135	105	105	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	15	135	127	127	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMIGD2	Q96BF3	15	135	44	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
TMIGD2	Q96BF3	149	187	186	189	Alternative sequence	ID=VSP_022967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
TMIGD2	Q96BF3	149	187	168	168	Natural variant	ID=VAR_061328;Note=W->L;Dbxref=dbSNP:rs58237134
AGXT	P21549	314	357	1	392	Chain	ID=PRO_0000150237;Note=Serine--pyruvate aminotransferase
AGXT	P21549	314	357	326	326	Natural variant	ID=VAR_060570;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559847;Dbxref=dbSNP:rs115057148,PMID:12559847
AGXT	P21549	314	357	336	336	Natural variant	ID=VAR_060571;Note=In HP1. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15253729;Dbxref=dbSNP:rs180177155,PMID:15253729
AGXT	P21549	314	357	340	340	Natural variant	ID=VAR_000593;Note=Common polymorphism%3B associated with hyperoxaluria. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1703535;Dbxref=dbSNP:rs4426527,PMID:1703535
AGXT	P21549	314	357	350	350	Natural variant	ID=VAR_060572;Note=In HP1. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9604803;Dbxref=dbSNP:rs180177156,PMID:9604803
AGXT	P21549	314	357	314	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9S
AGXT	P21549	314	357	321	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9S
AGXT	P21549	314	357	332	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9S
AGXT	P21549	314	357	344	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KYO
AGXT	P21549	314	357	352	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9S
AGXT	P21549	314	357	355	357	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9S
TMEM62	Q0P6H9	248	288	1	643	Chain	ID=PRO_0000254136;Note=Transmembrane protein 62
TMEM62	Q0P6H9	289	340	1	643	Chain	ID=PRO_0000254136;Note=Transmembrane protein 62
TMEM62	Q0P6H9	460	495	1	643	Chain	ID=PRO_0000254136;Note=Transmembrane protein 62
TMEM62	Q0P6H9	460	495	481	501	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM62	Q0P6H9	460	495	467	467	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	576	631	19	1030	Chain	ID=PRO_0000032339;Note=Semaphorin-6A
SEMA6A	Q9H2E6	417	475	19	1030	Chain	ID=PRO_0000032339;Note=Semaphorin-6A
SEMA6A	Q9H2E6	114	148	19	1030	Chain	ID=PRO_0000032339;Note=Semaphorin-6A
SEMA6A	Q9H2E6	576	631	19	1030	Chain	ID=PRO_0000032339;Note=Semaphorin-6A
SEMA6A	Q9H2E6	417	475	19	1030	Chain	ID=PRO_0000032339;Note=Semaphorin-6A
SEMA6A	Q9H2E6	114	148	19	1030	Chain	ID=PRO_0000032339;Note=Semaphorin-6A
SEMA6A	Q9H2E6	576	631	19	649	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	417	475	19	649	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	114	148	19	649	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	576	631	19	649	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	417	475	19	649	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	114	148	19	649	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	417	475	24	512	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	114	148	24	512	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	417	475	24	512	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	114	148	24	512	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	417	475	434	434	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	417	475	434	434	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	417	475	461	461	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	417	475	461	461	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA6A	Q9H2E6	114	148	107	117	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	114	148	107	117	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	114	148	135	144	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	114	148	135	144	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA6A	Q9H2E6	576	631	576	576	Alternative sequence	ID=VSP_007113;Note=In isoform 2. N->NDISTPLPDNEMSYNTVY;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEMA6A	Q9H2E6	576	631	576	576	Alternative sequence	ID=VSP_007113;Note=In isoform 2. N->NDISTPLPDNEMSYNTVY;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEPT3	Q9UH03	3	67	1	358	Chain	ID=PRO_0000173517;Note=Neuronal-specific septin-3
SEPT3	Q9UH03	67	110	1	358	Chain	ID=PRO_0000173517;Note=Neuronal-specific septin-3
SEPT3	Q9UH03	3	67	58	331	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT3	Q9UH03	67	110	58	331	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT3	Q9UH03	67	110	68	75	Nucleotide binding	Note=GTP
SEPT3	Q9UH03	67	110	68	75	Region	Note=G1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT3	Q9UH03	67	110	102	102	Binding site	Note=GTP
SEPT3	Q9UH03	67	110	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WU34
SEPT3	Q9UH03	67	110	68	83	Alternative sequence	ID=VSP_025398;Note=In isoform 3. GQSGLGKSTLVNTLFK->AGSPLRSTSMSSTRSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11322766;Dbxref=PMID:11322766
SEPT3	Q9UH03	67	110	84	358	Alternative sequence	ID=VSP_025399;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11322766;Dbxref=PMID:11322766
SEPT3	Q9UH03	3	67	45	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z54
SEPT3	Q9UH03	3	67	59	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z54
SEPT3	Q9UH03	67	110	59	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z54
SEPT3	Q9UH03	67	110	74	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z54
SEPT3	Q9UH03	67	110	106	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z54
SEPT5	Q99719	121	165	1	369	Chain	ID=PRO_0000173521;Note=Septin-5
SEPT5	Q99719	121	165	41	314	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SETD4	Q9NVD3	24	56	1	440	Chain	ID=PRO_0000079509;Note=SET domain-containing protein 4
SETD4	Q9NVD3	24	56	48	273	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SETD4	Q9NVD3	24	56	1	25	Alternative sequence	ID=VSP_026578;Note=In isoform 3. MQKGKGRTSRIRRRKLCGSSESRGV->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SETDB1	Q15047	527	737	1	1291	Chain	ID=PRO_0000186064;Note=Histone-lysine N-methyltransferase SETDB1
SETDB1	Q15047	527	737	594	665	Domain	Note=MBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00338
SETDB1	Q15047	527	737	727	800	Domain	Note=Pre-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00157
SETDB1	Q15047	527	737	729	729	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB1	Q15047	527	737	729	729	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB1	Q15047	527	737	731	731	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB1	Q15047	527	737	735	735	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB1	Q15047	527	737	735	735	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB1	Q15047	527	737	398	1291	Alternative sequence	ID=VSP_002218;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SETDB1	Q15047	527	737	729	731	Mutagenesis	Note=Abolishes methyltransferase activity. CDC->LDP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11959841;Dbxref=PMID:11959841
SEZ6	Q53EL9	18	241	1	19	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6	Q53EL9	897	910	20	994	Chain	ID=PRO_0000341346;Note=Seizure protein 6 homolog
SEZ6	Q53EL9	18	241	20	994	Chain	ID=PRO_0000341346;Note=Seizure protein 6 homolog
SEZ6	Q53EL9	897	910	20	925	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6	Q53EL9	18	241	20	925	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEZ6	Q53EL9	897	910	836	897	Domain	Note=Sushi 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
SEZ6	Q53EL9	18	241	38	47	Region	Note=O-glycosylated at two sites
SEZ6	Q53EL9	18	241	59	63	Region	Note=O-glycosylated at two sites
SEZ6	Q53EL9	18	241	90	188	Compositional bias	Note=Pro-rich
SEZ6	Q53EL9	18	241	211	240	Compositional bias	Note=Thr-rich
SEZ6	Q53EL9	18	241	1	125	Alternative sequence	ID=VSP_034250;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEZ6	Q53EL9	897	910	509	994	Alternative sequence	ID=VSP_034252;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
SEZ6	Q53EL9	18	241	78	78	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	78	78	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	78	78	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	93	93	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	93	93	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	93	93	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	141	141	Sequence conflict	Note=S->SPD;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	141	141	Sequence conflict	Note=S->SPD;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEZ6	Q53EL9	18	241	141	141	Sequence conflict	Note=S->SPD;Ontology_term=ECO:0000305;evidence=ECO:0000305
SETBP1	Q9Y6X0	162	180	1	1596	Chain	ID=PRO_0000097698;Note=SET-binding protein
SETBP1	Q9Y6X0	1333	1390	1	1596	Chain	ID=PRO_0000097698;Note=SET-binding protein
SETBP1	Q9Y6X0	1333	1390	243	1596	Alternative sequence	ID=VSP_039061;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SETBP1	Q9Y6X0	1333	1390	1377	1377	Natural variant	ID=VAR_069864;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23222956;Dbxref=dbSNP:rs77518617,PMID:23222956
SMIM20	Q8N5G0	36	55	1	67	Chain	ID=PRO_0000326049;Note=Small integral membrane protein 20
SMIM20	Q8N5G0	36	55	28	67	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26321642;Dbxref=PMID:26321642
SIKE1	Q9BRV8	136	174	1	207	Chain	ID=PRO_0000299050;Note=Suppressor of IKBKE 1
SIKE1	Q9BRV8	136	174	162	193	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SIKE1	Q9BRV8	136	174	169	169	Sequence conflict	Note=K->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIRT1	Q96EB6	263	314	2	747	Chain	ID=PRO_0000110256;Note=NAD-dependent protein deacetylase sirtuin-1
SIRT1	Q96EB6	452	638	2	747	Chain	ID=PRO_0000110256;Note=NAD-dependent protein deacetylase sirtuin-1
SIRT1	Q96EB6	263	314	2	533	Chain	ID=PRO_0000415289;Note=SirtT1 75 kDa fragment
SIRT1	Q96EB6	452	638	2	533	Chain	ID=PRO_0000415289;Note=SirtT1 75 kDa fragment
SIRT1	Q96EB6	263	314	244	498	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236
SIRT1	Q96EB6	452	638	244	498	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236
SIRT1	Q96EB6	263	314	261	280	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIRT1	Q96EB6	452	638	465	467	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIRT1	Q96EB6	263	314	2	268	Region	Note=Interaction with HIST1H1E
SIRT1	Q96EB6	263	314	143	541	Region	Note=Interaction with CCAR2
SIRT1	Q96EB6	452	638	143	541	Region	Note=Interaction with CCAR2
SIRT1	Q96EB6	452	638	538	540	Region	Note=Phosphorylated at one of three serine residues
SIRT1	Q96EB6	452	638	482	482	Binding site	Note=NAD%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIRT1	Q96EB6	452	638	530	530	Modified residue	Note=Phosphothreonine%3B by DYRK1A%2C DYRK3 and MAPK8;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:19107194,ECO:0000269|PubMed:20027304;Dbxref=PMID:19690332,PMID:19107194,PMID:20027304
SIRT1	Q96EB6	452	638	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SIRT1	Q96EB6	452	638	544	544	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19107194;Dbxref=PMID:19107194
SIRT1	Q96EB6	452	638	545	545	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19107194;Dbxref=PMID:19107194
SIRT1	Q96EB6	452	638	454	639	Alternative sequence	ID=VSP_042189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIRT1	Q96EB6	452	638	484	484	Natural variant	ID=VAR_051976;Note=V->D;Dbxref=dbSNP:rs1063111
SIRT1	Q96EB6	452	638	474	474	Mutagenesis	Note=Abolishes phosphorylation at Ser-47%2C restores deacetylation activity and inhibits DNA damage-induced apoptosis. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21471201;Dbxref=PMID:21471201
SIRT1	Q96EB6	452	638	530	530	Mutagenesis	Note=Greatly diminishes phosphorylation by MAPK8%3B when associated with A-27 and A-47. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19107194,ECO:0000269|PubMed:20027304;Dbxref=PMID:19107194,PMID:20027304
SIRT1	Q96EB6	452	638	530	530	Mutagenesis	Note=Reduces in vitro phosphorylation by CDK1. Impairs cell proliferation and cell cycle progression%3B when associated with A-540. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19107194,ECO:0000269|PubMed:20027304;Dbxref=PMID:19107194,PMID:20027304
SIRT1	Q96EB6	452	638	540	540	Mutagenesis	Note=Reduces in vitro phosphorylation by CDK1. Impairs cell proliferation and cell cycle progression%3B when associated with A-530. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19107194;Dbxref=PMID:19107194
SIRT1	Q96EB6	263	314	262	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	273	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	276	278	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IG9
SIRT1	Q96EB6	263	314	279	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	290	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	293	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	299	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	307	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	263	314	313	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	452	638	451	454	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	452	638	455	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	461	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	452	638	475	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	452	638	482	493	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	452	638	495	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXQ
SIRT1	Q96EB6	452	638	502	507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	515	517	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	526	531	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	542	548	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	549	551	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	554	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	571	573	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	574	577	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	582	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	599	604	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	606	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	618	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SIRT1	Q96EB6	452	638	629	633	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BTR
SKA2	Q8WVK7	40	99	1	121	Chain	ID=PRO_0000266035;Note=Spindle and kinetochore-associated protein 2
SKA2	Q8WVK7	40	99	1	75	Alternative sequence	ID=VSP_047348;Note=In isoform 2. MEAEVDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESK->MASEVGHNLESPETPGGGGWTRVEFPPPAPKGAATVWCLNRLGSRKLSLIWITFNTGWNMKSRLIILIQQVSCHH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SKA2	Q8WVK7	40	99	76	121	Alternative sequence	ID=VSP_047349;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SKA2	Q8WVK7	40	99	44	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJ5
SLC9A1	P19634	549	606	1	815	Chain	ID=PRO_0000052347;Note=Sodium/hydrogen exchanger 1
SLC9A1	P19634	549	606	500	815	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A1	P19634	549	606	599	599	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SLC9A1	P19634	549	606	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SLC9A1	P19634	549	606	603	603	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61165
SLC9A1	P19634	549	606	605	605	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLC9A1	P19634	549	606	496	554	Alternative sequence	ID=VSP_022101;Note=In isoform 2. GMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFN->VLGQGRAGPCLGDPHRLFPWKERKACDLKCDSSPSSTTNLLCDLGRATPPFWASVSSIVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC9A1	P19634	549	606	555	815	Alternative sequence	ID=VSP_022102;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SKP2	Q13309	131	178	1	424	Chain	ID=PRO_0000119954;Note=S-phase kinase-associated protein 2
SKP2	Q13309	179	223	1	424	Chain	ID=PRO_0000119954;Note=S-phase kinase-associated protein 2
SKP2	Q13309	224	256	1	424	Chain	ID=PRO_0000119954;Note=S-phase kinase-associated protein 2
SKP2	Q13309	131	178	94	140	Domain	Note=F-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00080
SKP2	Q13309	131	178	151	176	Repeat	Note=LRR 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11099048;Dbxref=PMID:11099048
SKP2	Q13309	131	178	177	204	Repeat	Note=LRR 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11099048;Dbxref=PMID:11099048
SKP2	Q13309	179	223	177	204	Repeat	Note=LRR 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11099048;Dbxref=PMID:11099048
SKP2	Q13309	179	223	210	234	Repeat	Note=LRR 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11099048;Dbxref=PMID:11099048
SKP2	Q13309	224	256	210	234	Repeat	Note=LRR 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11099048;Dbxref=PMID:11099048
SKP2	Q13309	224	256	235	257	Repeat	Note=LRR 4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11099048;Dbxref=PMID:11099048
SKP2	Q13309	131	178	1	220	Region	Note=Mediates interaction with hepatitis C virus non-structural protein NS5A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27194766;Dbxref=PMID:27194766
SKP2	Q13309	179	223	1	220	Region	Note=Mediates interaction with hepatitis C virus non-structural protein NS5A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27194766;Dbxref=PMID:27194766
SKP2	Q13309	179	223	179	179	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:23186163;Dbxref=PMID:18220336,PMID:23186163
SKP2	Q13309	131	178	1	169	Alternative sequence	ID=VSP_044931;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SKP2	Q13309	179	223	180	224	Alternative sequence	ID=VSP_044932;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SKP2	Q13309	224	256	180	224	Alternative sequence	ID=VSP_044932;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SKP2	Q13309	179	223	185	185	Sequence conflict	Note=H->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	179	223	215	215	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	224	256	238	238	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	224	256	241	241	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	224	256	244	247	Sequence conflict	Note=SEFA->PKFP;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	224	256	251	251	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	224	256	256	256	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SKP2	Q13309	131	178	125	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FS1
SKP2	Q13309	131	178	134	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FS1
SKP2	Q13309	131	178	137	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	131	178	149	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	131	178	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	179	223	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FS2
SKP2	Q13309	179	223	185	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	179	223	195	202	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	179	223	209	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	179	223	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	224	256	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	224	256	233	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SKP2	Q13309	224	256	245	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AST
SLC9A9	Q8IVB4	126	152	1	645	Chain	ID=PRO_0000052367;Note=Sodium/hydrogen exchanger 9
SLC9A9	Q8IVB4	126	152	127	147	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLA	Q13239	117	161	2	276	Chain	ID=PRO_0000071946;Note=Src-like-adapter
SLA	Q13239	117	161	84	175	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
SLA	Q13239	117	161	118	161	Alternative sequence	ID=VSP_055125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SMARCA1	P28370	814	855	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	776	814	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	542	554	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	366	389	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	322	366	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	210	270	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	58	87	1	1054	Chain	ID=PRO_0000074351;Note=Probable global transcription activator SNF2L1
SMARCA1	P28370	322	366	195	360	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCA1	P28370	210	270	195	360	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCA1	P28370	542	554	490	653	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
SMARCA1	P28370	814	855	855	907	Domain	Note=SANT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
SMARCA1	P28370	210	270	208	215	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCA1	P28370	542	554	543	554	Alternative sequence	ID=VSP_020406;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15310751;Dbxref=PMID:15310751
SMARCA1	P28370	210	270	214	214	Mutagenesis	Note=No effect on neurite outgrowth. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14609955;Dbxref=PMID:14609955
SNRPD1	P62314	30	94	1	119	Chain	ID=PRO_0000122201;Note=Small nuclear ribonucleoprotein Sm D1
SNRPD1	P62314	30	94	1	80	Region	Note=Sufficient for interaction with CLNS1A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11747828;Dbxref=PMID:11747828
SNRPD1	P62314	30	94	86	119	Compositional bias	Note=Arg/Lys-rich (basic)
SNRPD1	P62314	30	94	86	86	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SNRPD1	P62314	30	94	58	58	Mutagenesis	Note=Loss of interaction with CLNS1A. L->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11747828;Dbxref=PMID:11747828
SNRPD1	P62314	30	94	60	60	Mutagenesis	Note=Loss of interaction with CLNS1A. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11747828;Dbxref=PMID:11747828
SNRPD1	P62314	30	94	24	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD1	P62314	30	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD1	P62314	30	94	53	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD1	P62314	30	94	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD1	P62314	30	94	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SNRPD1	P62314	30	94	76	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1B34
SMARCA4	P51532	253	286	1	1647	Chain	ID=PRO_0000074353;Note=Transcription activator BRG1
SMARCA4	P51532	1258	1291	1	1647	Chain	ID=PRO_0000074353;Note=Transcription activator BRG1
SMARCA4	P51532	1511	1545	1	1647	Chain	ID=PRO_0000074353;Note=Transcription activator BRG1
SMARCA4	P51532	253	286	1	1647	Chain	ID=PRO_0000074353;Note=Transcription activator BRG1
SMARCA4	P51532	1258	1291	1	1647	Chain	ID=PRO_0000074353;Note=Transcription activator BRG1
SMARCA4	P51532	1511	1545	1	1647	Chain	ID=PRO_0000074353;Note=Transcription activator BRG1
SMARCA4	P51532	1511	1545	1477	1547	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
SMARCA4	P51532	1511	1545	1477	1547	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
SMARCA4	P51532	253	286	1	282	Region	Note=Necessary for interaction with SS18L1/CREST;Ontology_term=ECO:0000250;evidence=ECO:0000250
SMARCA4	P51532	253	286	1	282	Region	Note=Necessary for interaction with SS18L1/CREST;Ontology_term=ECO:0000250;evidence=ECO:0000250
SMARCA4	P51532	1258	1291	1247	1446	Region	Note=Sufficient for interaction with DLX1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TKT4
SMARCA4	P51532	1258	1291	1247	1446	Region	Note=Sufficient for interaction with DLX1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TKT4
SMARCA4	P51532	1511	1545	1539	1540	Site	Note=Required for binding to 'Lys-15'-acetylated histone 3
SMARCA4	P51532	1511	1545	1539	1540	Site	Note=Required for binding to 'Lys-15'-acetylated histone 3
SMARCA4	P51532	1258	1291	1259	1291	Alternative sequence	ID=VSP_043137;Note=In isoform 2%2C isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18386774;Dbxref=PMID:18386774
SMARCA4	P51532	1258	1291	1259	1291	Alternative sequence	ID=VSP_043137;Note=In isoform 2%2C isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18386774;Dbxref=PMID:18386774
SMARCA4	P51532	1511	1545	1539	1539	Mutagenesis	Note=Abolishes binding to 'Lys-15'-acetylated histone H3. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17274598;Dbxref=PMID:17274598
SMARCA4	P51532	1511	1545	1539	1539	Mutagenesis	Note=Abolishes binding to 'Lys-15'-acetylated histone H3. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17274598;Dbxref=PMID:17274598
SMARCA4	P51532	1511	1545	1540	1540	Mutagenesis	Note=Abolishes binding to 'Lys-15'-acetylated histone H3. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17274598;Dbxref=PMID:17274598
SMARCA4	P51532	1511	1545	1540	1540	Mutagenesis	Note=Abolishes binding to 'Lys-15'-acetylated histone H3. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17274598;Dbxref=PMID:17274598
SMARCA4	P51532	1511	1545	1507	1515	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRC
SMARCA4	P51532	1511	1545	1507	1515	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRC
SMARCA4	P51532	1511	1545	1522	1539	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRC
SMARCA4	P51532	1511	1545	1522	1539	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRC
SMARCA4	P51532	1511	1545	1542	1544	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H60
SMARCA4	P51532	1511	1545	1542	1544	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H60
SMARCA4	P51532	1511	1545	1545	1567	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRC
SMARCA4	P51532	1511	1545	1545	1567	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GRC
SMARCA5	O60264	207	267	2	1052	Chain	ID=PRO_0000074354;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
SMARCA5	O60264	267	319	2	1052	Chain	ID=PRO_0000074354;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
SMARCA5	O60264	799	840	2	1052	Chain	ID=PRO_0000074354;Note=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
SMARCA5	O60264	207	267	192	357	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCA5	O60264	267	319	192	357	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
SMARCA5	O60264	799	840	840	892	Domain	Note=SANT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
SMARCA5	O60264	207	267	205	212	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMARCA5	O60264	267	319	308	311	Motif	Note=DEAH box
SMARCA5	O60264	799	840	825	825	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
SMARCA5	O60264	207	267	211	211	Mutagenesis	Note=Loss of ATP hydrolysis and no association of the SMARCA5/cohesin/NuRD complex with chromatin. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12198550;Dbxref=PMID:12198550
SND1	Q7KZF4	346	384	2	910	Chain	ID=PRO_0000183180;Note=Staphylococcal nuclease domain-containing protein 1
SND1	Q7KZF4	384	414	2	910	Chain	ID=PRO_0000183180;Note=Staphylococcal nuclease domain-containing protein 1
SND1	Q7KZF4	448	484	2	910	Chain	ID=PRO_0000183180;Note=Staphylococcal nuclease domain-containing protein 1
SND1	Q7KZF4	593	656	2	910	Chain	ID=PRO_0000183180;Note=Staphylococcal nuclease domain-containing protein 1
SND1	Q7KZF4	768	806	2	910	Chain	ID=PRO_0000183180;Note=Staphylococcal nuclease domain-containing protein 1
SND1	Q7KZF4	806	874	2	910	Chain	ID=PRO_0000183180;Note=Staphylococcal nuclease domain-containing protein 1
SND1	Q7KZF4	346	384	341	496	Domain	Note=TNase-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00272
SND1	Q7KZF4	384	414	341	496	Domain	Note=TNase-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00272
SND1	Q7KZF4	448	484	341	496	Domain	Note=TNase-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00272
SND1	Q7KZF4	593	656	525	660	Domain	Note=TNase-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00272
SND1	Q7KZF4	768	806	729	787	Domain	Note=Tudor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00211
SND1	Q7KZF4	384	414	388	392	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SND1	Q7KZF4	593	656	641	641	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SND1	Q7KZF4	593	656	645	645	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SND1	Q7KZF4	768	806	779	779	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SND1	Q7KZF4	768	806	781	781	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
SND1	Q7KZF4	768	806	785	785	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SND1	Q7KZF4	346	384	341	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	346	384	352	354	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	346	384	355	359	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	346	384	365	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	346	384	384	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	384	414	384	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	384	414	387	389	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	384	414	392	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	384	414	399	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	384	414	414	425	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	448	484	450	456	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	448	484	459	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	448	484	476	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	593	601	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	607	613	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	618	624	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	627	630	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	632	634	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	640	653	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	593	656	656	658	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BDL
SND1	Q7KZF4	768	806	769	772	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQX
SND1	Q7KZF4	768	806	774	776	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQX
SND1	Q7KZF4	768	806	777	779	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	768	806	782	784	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQX
SND1	Q7KZF4	768	806	786	788	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQX
SND1	Q7KZF4	768	806	794	798	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	807	821	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	824	832	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	835	837	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	839	844	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	845	847	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	851	857	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	860	863	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	869	871	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SND1	Q7KZF4	806	874	872	887	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M9O
SLCO1C1	Q9NYB5	176	225	1	712	Chain	ID=PRO_0000191054;Note=Solute carrier organic anion transporter family member 1C1
SLCO1C1	Q9NYB5	176	225	135	184	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO1C1	Q9NYB5	176	225	185	213	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO1C1	Q9NYB5	176	225	214	232	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO1C1	Q9NYB5	176	225	177	225	Alternative sequence	ID=VSP_042882;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNX5	Q9Y5X3	277	306	2	404	Chain	ID=PRO_0000213844;Note=Sorting nexin-5
SNX5	Q9Y5X3	52	89	2	404	Chain	ID=PRO_0000213844;Note=Sorting nexin-5
SNX5	Q9Y5X3	277	306	2	404	Chain	ID=PRO_0000213844;Note=Sorting nexin-5
SNX5	Q9Y5X3	52	89	2	404	Chain	ID=PRO_0000213844;Note=Sorting nexin-5
SNX5	Q9Y5X3	52	89	25	172	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX5	Q9Y5X3	52	89	25	172	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX5	Q9Y5X3	277	306	202	404	Domain	Note=BAR
SNX5	Q9Y5X3	277	306	202	404	Domain	Note=BAR
SNX5	Q9Y5X3	52	89	18	126	Alternative sequence	ID=VSP_056386;Note=In isoform 2. LRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQ->VRSSQPQTPGRAALRAPGSLHSFPCASIGRGCSPPSPAREAPVRPGRPLSLVFTEGCPGESLWMSRILLGQNQRRGTLAPAQAPVPSGLGEMISGDPGMFFLKLSSASW;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SNX5	Q9Y5X3	52	89	18	126	Alternative sequence	ID=VSP_056386;Note=In isoform 2. LRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQ->VRSSQPQTPGRAALRAPGSLHSFPCASIGRGCSPPSPAREAPVRPGRPLSLVFTEGCPGESLWMSRILLGQNQRRGTLAPAQAPVPSGLGEMISGDPGMFFLKLSSASW;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SNX5	Q9Y5X3	277	306	127	404	Alternative sequence	ID=VSP_056387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SNX5	Q9Y5X3	277	306	127	404	Alternative sequence	ID=VSP_056387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
SNX5	Q9Y5X3	277	306	280	280	Mutagenesis	Note=Enables homodimerization%3B when associated with A-383. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23085988;Dbxref=PMID:23085988
SNX5	Q9Y5X3	277	306	280	280	Mutagenesis	Note=Enables homodimerization%3B when associated with A-383. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23085988;Dbxref=PMID:23085988
SNX5	Q9Y5X3	277	306	279	279	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX5	Q9Y5X3	277	306	279	279	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX5	Q9Y5X3	52	89	44	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	44	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	56	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TGH
SNX5	Q9Y5X3	52	89	56	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TGH
SNX5	Q9Y5X3	52	89	61	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	61	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	69	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	69	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SNX5	Q9Y5X3	52	89	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WY2
SLC47A2	Q86VL8	278	316	1	602	Chain	ID=PRO_0000311952;Note=Multidrug and toxin extrusion protein 2
SLC47A2	Q86VL8	75	98	1	602	Chain	ID=PRO_0000311952;Note=Multidrug and toxin extrusion protein 2
SLC47A2	Q86VL8	75	98	67	87	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A2	Q86VL8	75	98	88	119	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A2	Q86VL8	278	316	270	289	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A2	Q86VL8	278	316	290	309	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A2	Q86VL8	278	316	310	327	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC47A2	Q86VL8	278	316	220	602	Alternative sequence	ID=VSP_029659;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16807400;Dbxref=PMID:16807400
SLC47A2	Q86VL8	75	98	93	93	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC47A2	Q86VL8	278	316	284	284	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
RELA	Q04206	221	292	1	551	Chain	ID=PRO_0000205169;Note=Transcription factor p65
RELA	Q04206	186	221	1	551	Chain	ID=PRO_0000205169;Note=Transcription factor p65
RELA	Q04206	221	292	19	306	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
RELA	Q04206	186	221	19	306	Domain	Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265
RELA	Q04206	186	221	218	218	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12456660;Dbxref=PMID:12456660
RELA	Q04206	221	292	221	221	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12456660;Dbxref=PMID:12456660
RELA	Q04206	186	221	221	221	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12456660;Dbxref=PMID:12456660
RELA	Q04206	221	292	254	254	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14690596;Dbxref=PMID:14690596
RELA	Q04206	221	292	276	276	Modified residue	Note=Phosphoserine%3B by RPS6KA4 and RPS6KA5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12628924;Dbxref=PMID:12628924
RELA	Q04206	221	292	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15516339;Dbxref=PMID:15516339
RELA	Q04206	221	292	222	231	Alternative sequence	ID=VSP_012031;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1732726;Dbxref=PMID:1732726
RELA	Q04206	221	292	254	254	Mutagenesis	Note=Abolishes interaction with PIN1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14690596;Dbxref=PMID:14690596
RELA	Q04206	221	292	276	276	Mutagenesis	Note=Loss of phosphorylation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12628924;Dbxref=PMID:12628924
RELA	Q04206	186	221	183	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	186	221	196	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	186	221	202	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	186	221	211	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	225	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	233	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	241	243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	246	248	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	249	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	258	260	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2O61
RELA	Q04206	221	292	266	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	275	277	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
RELA	Q04206	221	292	284	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NFI
SLC27A5	Q9Y2P5	394	459	1	690	Chain	ID=PRO_0000193213;Note=Bile acyl-CoA synthetase
SLC27A5	Q9Y2P5	394	459	77	690	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11980911;Dbxref=PMID:11980911
UBA2	Q9UBT2	46	74	1	640	Chain	ID=PRO_0000194968;Note=SUMO-activating enzyme subunit 2
UBA2	Q9UBT2	415	467	1	640	Chain	ID=PRO_0000194968;Note=SUMO-activating enzyme subunit 2
UBA2	Q9UBT2	46	74	56	59	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15660128;Dbxref=PMID:15660128
UBA2	Q9UBT2	415	467	441	441	Metal binding	Note=Zinc
UBA2	Q9UBT2	415	467	444	444	Metal binding	Note=Zinc
UBA2	Q9UBT2	46	74	48	48	Binding site	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15660128;Dbxref=PMID:15660128
UBA2	Q9UBT2	46	74	72	72	Binding site	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15660128;Dbxref=PMID:15660128
UBA2	Q9UBT2	415	467	420	420	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBA2	Q9UBT2	415	467	420	420	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
UBA2	Q9UBT2	46	74	1	96	Alternative sequence	ID=VSP_056164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBA2	Q9UBT2	46	74	56	56	Mutagenesis	Note=Abolishes ATP-dependent activation of SUMO proteins. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164921;Dbxref=PMID:20164921
UBA2	Q9UBT2	46	74	57	57	Mutagenesis	Note=Strongly reduces ATP-dependent activation of SUMO proteins. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164921;Dbxref=PMID:20164921
UBA2	Q9UBT2	46	74	59	59	Mutagenesis	Note=Strongly reduces ATP-dependent activation of SUMO proteins. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164921;Dbxref=PMID:20164921
UBA2	Q9UBT2	46	74	72	72	Mutagenesis	Note=Abolishes ATP-dependent activation of SUMO proteins. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164921;Dbxref=PMID:20164921
UBA2	Q9UBT2	415	467	456	456	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBA2	Q9UBT2	46	74	43	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	46	74	54	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	46	74	65	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	46	74	72	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	415	467	414	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	415	467	426	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	415	467	442	444	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	415	467	445	447	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y8Q
UBA2	Q9UBT2	415	467	449	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQ2
UBA2	Q9UBT2	415	467	456	458	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQ2
UBA2	Q9UBT2	415	467	461	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQ2
UBA2	Q9UBT2	415	467	467	472	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQ2
SAGE1	Q9NXZ1	73	104	1	904	Chain	ID=PRO_0000286971;Note=Sarcoma antigen 1
SAGE1	Q9NXZ1	339	386	1	904	Chain	ID=PRO_0000286971;Note=Sarcoma antigen 1
SAGE1	Q9NXZ1	73	104	1	904	Chain	ID=PRO_0000286971;Note=Sarcoma antigen 1
SAGE1	Q9NXZ1	339	386	1	904	Chain	ID=PRO_0000286971;Note=Sarcoma antigen 1
AHCY	P23526	324	389	2	432	Chain	ID=PRO_0000116902;Note=Adenosylhomocysteinase
AHCY	P23526	324	389	346	346	Binding site	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12590576,ECO:0000269|PubMed:9586999;Dbxref=PMID:12590576,PMID:9586999
AHCY	P23526	324	389	353	353	Binding site	Note=NAD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12590576,ECO:0000269|PubMed:9586999;Dbxref=PMID:12590576,PMID:9586999
AHCY	P23526	324	389	325	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	335	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	340	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	345	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	355	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	376	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	381	384	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
AHCY	P23526	324	389	388	399	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LI4
SLC7A6OS	Q96CW6	157	226	1	309	Chain	ID=PRO_0000289169;Note=Probable RNA polymerase II nuclear localization protein SLC7A6OS
SLC7A6OS	Q96CW6	157	226	220	220	Natural variant	ID=VAR_032594;Note=Y->C;Dbxref=dbSNP:rs11548855
SEC31B	Q9NQW1	1008	1057	1	1179	Chain	ID=PRO_0000295153;Note=Protein transport protein Sec31B
SEC31B	Q9NQW1	883	988	1	1179	Chain	ID=PRO_0000295153;Note=Protein transport protein Sec31B
SEC31B	Q9NQW1	393	470	1	1179	Chain	ID=PRO_0000295153;Note=Protein transport protein Sec31B
SEC31B	Q9NQW1	393	470	391	422	Repeat	Note=WD 8%3B interaction with SEC13;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00221
SEC31B	Q9NQW1	1008	1057	821	1073	Compositional bias	Note=Pro-rich
SEC31B	Q9NQW1	883	988	821	1073	Compositional bias	Note=Pro-rich
SEC31B	Q9NQW1	1008	1057	86	1179	Alternative sequence	ID=VSP_026758;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SEC31B	Q9NQW1	883	988	86	1179	Alternative sequence	ID=VSP_026758;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SEC31B	Q9NQW1	393	470	86	1179	Alternative sequence	ID=VSP_026758;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SEC31B	Q9NQW1	1008	1057	350	1179	Alternative sequence	ID=VSP_026761;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC31B	Q9NQW1	883	988	350	1179	Alternative sequence	ID=VSP_026761;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC31B	Q9NQW1	393	470	350	1179	Alternative sequence	ID=VSP_026761;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEC31B	Q9NQW1	393	470	470	482	Alternative sequence	ID=VSP_026762;Note=In isoform 4. KVTLEQDSRMKFL->KPARDSSGARR;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC31B	Q9NQW1	1008	1057	483	1179	Alternative sequence	ID=VSP_026763;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC31B	Q9NQW1	883	988	483	1179	Alternative sequence	ID=VSP_026763;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC31B	Q9NQW1	393	470	433	433	Natural variant	ID=VAR_053415;Note=R->Q;Dbxref=dbSNP:rs2295771
SLC5A7	Q9GZV3	59	97	1	580	Chain	ID=PRO_0000105391;Note=High affinity choline transporter 1
SLC5A7	Q9GZV3	59	97	1	580	Chain	ID=PRO_0000105391;Note=High affinity choline transporter 1
SLC5A7	Q9GZV3	59	97	49	69	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A7	Q9GZV3	59	97	49	69	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A7	Q9GZV3	59	97	70	81	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A7	Q9GZV3	59	97	70	81	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A7	Q9GZV3	59	97	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A7	Q9GZV3	59	97	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC5A7	Q9GZV3	59	97	65	65	Natural variant	ID=VAR_077855;Note=In CMS20%3B loss of choline transmembrane transporter activity%3B no effect on localization at plasma membrane. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27569547;Dbxref=dbSNP:rs886039765,PMID:27569547
SLC5A7	Q9GZV3	59	97	65	65	Natural variant	ID=VAR_077855;Note=In CMS20%3B loss of choline transmembrane transporter activity%3B no effect on localization at plasma membrane. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27569547;Dbxref=dbSNP:rs886039765,PMID:27569547
SLC5A7	Q9GZV3	59	97	89	89	Natural variant	ID=VAR_020524;Note=40%25 reduction in choline uptake rate%3B found in 0.06 of Ashkenazi Jews. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12237312;Dbxref=dbSNP:rs1013940,PMID:12237312
SLC5A7	Q9GZV3	59	97	89	89	Natural variant	ID=VAR_020524;Note=40%25 reduction in choline uptake rate%3B found in 0.06 of Ashkenazi Jews. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12237312;Dbxref=dbSNP:rs1013940,PMID:12237312
SLC5A7	Q9GZV3	59	97	89	89	Mutagenesis	Note=Only 20%25 of wild-type choline uptake activity. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23132865;Dbxref=PMID:23132865
SLC5A7	Q9GZV3	59	97	89	89	Mutagenesis	Note=Only 20%25 of wild-type choline uptake activity. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23132865;Dbxref=PMID:23132865
SEC23A	Q15436	633	662	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	579	633	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	553	579	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	436	466	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	409	436	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	276	329	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	93	122	2	765	Chain	ID=PRO_0000205146;Note=Protein transport protein Sec23A
SEC23A	Q15436	633	662	632	718	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23A	Q15436	579	633	632	718	Repeat	Note=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC23A	Q15436	276	329	308	308	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SEC23A	Q15436	93	122	1	202	Alternative sequence	ID=VSP_056230;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEC23A	Q15436	579	633	628	628	Mutagenesis	Note=Decreased interaction with MIA3%3B when associated with A-681. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27551091;Dbxref=PMID:27551091
SEC23A	Q15436	579	633	623	623	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SEC23A	Q15436	93	122	91	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	93	122	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	93	122	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VNL
SEC23A	Q15436	93	122	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	93	122	112	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	93	122	115	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	276	329	264	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	276	329	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	276	329	296	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	276	329	313	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	276	329	324	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	409	436	401	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	409	436	414	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	409	436	431	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EG9
SEC23A	Q15436	436	466	439	442	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VNL
SEC23A	Q15436	436	466	444	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	436	466	457	463	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	553	579	542	557	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	553	579	558	561	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EGD
SEC23A	Q15436	553	579	565	567	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	553	579	572	576	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	579	633	577	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	553	579	577	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	579	633	588	590	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	579	633	592	594	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EFO
SEC23A	Q15436	579	633	597	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	579	633	612	619	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	579	633	622	626	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	579	633	628	631	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	633	662	633	635	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VNF
SEC23A	Q15436	579	633	633	635	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VNF
SEC23A	Q15436	633	662	639	641	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	633	662	647	651	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	633	662	653	660	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SEC23A	Q15436	633	662	662	670	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NUT
SCNN1B	P51168	348	384	1	640	Chain	ID=PRO_0000181268;Note=Amiloride-sensitive sodium channel subunit beta
SCNN1B	P51168	348	384	72	532	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P37089
SCNN1B	P51168	348	384	348	348	Natural variant	ID=VAR_062405;Note=In BESC1. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19017867;Dbxref=dbSNP:rs61759921,PMID:19017867
SCNN1B	P51168	348	384	369	369	Natural variant	ID=VAR_062406;Note=In BESC1. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18507830;Dbxref=dbSNP:rs137852711,PMID:18507830
SECISBP2	Q96T21	404	434	1	854	Chain	ID=PRO_0000097655;Note=Selenocysteine insertion sequence-binding protein 2
SECISBP2	Q96T21	404	434	428	428	Natural variant	ID=VAR_061704;Note=Q->E;Dbxref=dbSNP:rs45452691
SEC63	Q9UGP8	645	678	1	760	Chain	ID=PRO_0000071097;Note=Translocation protein SEC63 homolog
SEC63	Q9UGP8	611	645	1	760	Chain	ID=PRO_0000071097;Note=Translocation protein SEC63 homolog
SEC63	Q9UGP8	558	611	1	760	Chain	ID=PRO_0000071097;Note=Translocation protein SEC63 homolog
SEC63	Q9UGP8	500	558	1	760	Chain	ID=PRO_0000071097;Note=Translocation protein SEC63 homolog
SEC63	Q9UGP8	191	208	1	760	Chain	ID=PRO_0000071097;Note=Translocation protein SEC63 homolog
SEC63	Q9UGP8	191	208	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	645	678	210	760	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	611	645	210	760	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	558	611	210	760	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	500	558	210	760	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	500	558	197	541	Domain	Note=SEC63 1
SEC63	Q9UGP8	191	208	197	541	Domain	Note=SEC63 1
SEC63	Q9UGP8	645	678	637	714	Domain	Note=SEC63 2
SEC63	Q9UGP8	611	645	637	714	Domain	Note=SEC63 2
SEC63	Q9UGP8	611	645	597	635	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	558	611	597	635	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SEC63	Q9UGP8	500	558	537	537	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SEC63	Q9UGP8	645	678	7	760	Natural variant	ID=VAR_080944;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	7	760	Natural variant	ID=VAR_080944;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	7	760	Natural variant	ID=VAR_080944;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	7	760	Natural variant	ID=VAR_080944;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	191	208	7	760	Natural variant	ID=VAR_080944;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	58	760	Natural variant	ID=VAR_080945;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	58	760	Natural variant	ID=VAR_080945;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	58	760	Natural variant	ID=VAR_080945;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	58	760	Natural variant	ID=VAR_080945;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	191	208	58	760	Natural variant	ID=VAR_080945;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	98	760	Natural variant	ID=VAR_080946;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	98	760	Natural variant	ID=VAR_080946;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	98	760	Natural variant	ID=VAR_080946;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	98	760	Natural variant	ID=VAR_080946;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	191	208	98	760	Natural variant	ID=VAR_080946;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	233	760	Natural variant	ID=VAR_080947;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	233	760	Natural variant	ID=VAR_080947;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	233	760	Natural variant	ID=VAR_080947;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	233	760	Natural variant	ID=VAR_080947;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	239	760	Natural variant	ID=VAR_080948;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	239	760	Natural variant	ID=VAR_080948;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	239	760	Natural variant	ID=VAR_080948;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	239	760	Natural variant	ID=VAR_080948;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	297	760	Natural variant	ID=VAR_080949;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	297	760	Natural variant	ID=VAR_080949;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	297	760	Natural variant	ID=VAR_080949;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	297	760	Natural variant	ID=VAR_080949;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	417	760	Natural variant	ID=VAR_080950;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	417	760	Natural variant	ID=VAR_080950;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	417	760	Natural variant	ID=VAR_080950;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	417	760	Natural variant	ID=VAR_080950;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	645	678	550	760	Natural variant	ID=VAR_080951;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	550	760	Natural variant	ID=VAR_080951;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	550	760	Natural variant	ID=VAR_080951;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	550	760	Natural variant	ID=VAR_080951;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	500	558	556	556	Natural variant	ID=VAR_061146;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14574404;Dbxref=dbSNP:rs17854547,PMID:14574404
SEC63	Q9UGP8	558	611	568	568	Natural variant	ID=VAR_019645;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15133510;Dbxref=PMID:15133510
SEC63	Q9UGP8	645	678	601	760	Natural variant	ID=VAR_080952;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	611	645	601	760	Natural variant	ID=VAR_080952;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEC63	Q9UGP8	558	611	601	760	Natural variant	ID=VAR_080952;Note=In PCLD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28375157;Dbxref=PMID:28375157
SEMA3F	Q13275	152	183	19	785	Chain	ID=PRO_0000032320;Note=Semaphorin-3F
SEMA3F	Q13275	152	183	31	545	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA3F	Q13275	152	183	153	183	Alternative sequence	ID=VSP_053417;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8786119;Dbxref=PMID:8786119
SENP6	Q9GZR1	692	731	1	1112	Chain	ID=PRO_0000101725;Note=Sentrin-specific protease 6
SENP6	Q9GZR1	970	992	1	1112	Chain	ID=PRO_0000101725;Note=Sentrin-specific protease 6
SENP6	Q9GZR1	692	731	666	1112	Region	Note=Protease
SENP6	Q9GZR1	970	992	666	1112	Region	Note=Protease
SENP6	Q9GZR1	692	731	717	717	Natural variant	ID=VAR_029655;Note=R->P;Dbxref=dbSNP:rs12195603
SEMA5B	Q9P283	1015	1030	1	1151	Chain	ID=PRO_0000032337;Note=Semaphorin-5B
SEMA5B	Q9P283	1015	1030	1	1036	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA5B	Q9P283	1015	1030	1028	1028	Natural variant	ID=VAR_037202;Note=D->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2303983,PMID:10819331,PMID:14702039,PMID:15489334
SEPT6	Q14141	176	230	2	434	Chain	ID=PRO_0000173525;Note=Septin-6
SEPT6	Q14141	176	230	39	305	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT6	Q14141	176	230	185	193	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17637674;Dbxref=PMID:17637674
SEPT6	Q14141	176	230	184	187	Region	Note=G4 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SFR1	Q86XK3	45	182	1	245	Chain	ID=PRO_0000089805;Note=Swi5-dependent recombination DNA repair protein 1 homolog
SFR1	Q86XK3	45	182	149	177	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SFR1	Q86XK3	45	182	61	61	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
SFR1	Q86XK3	45	182	64	64	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BP27
SUGT1	Q9Y2Z0	109	141	2	365	Chain	ID=PRO_0000106332;Note=Protein SGT1 homolog
SUGT1	Q9Y2Z0	109	141	79	112	Repeat	Note=TPR 3
SUGT1	Q9Y2Z0	109	141	110	142	Alternative sequence	ID=VSP_013420;Note=In isoform 2. IETGFHRVGQAGLQLLTSSDPPALDSQSAGITG->S;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10445024,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4,ECO:0000303|Ref.5;Dbxref=PMID:10445024,PMID:15489334
SUGT1	Q9Y2Z0	109	141	120	120	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SENP1	Q9P0U3	332	344	1	644	Chain	ID=PRO_0000101716;Note=Sentrin-specific protease 1
SENP1	Q9P0U3	332	344	1	644	Chain	ID=PRO_0000101716;Note=Sentrin-specific protease 1
SEPT4	O43236	305	339	1	478	Chain	ID=PRO_0000173519;Note=Septin-4
SEPT4	O43236	20	119	1	478	Chain	ID=PRO_0000173519;Note=Septin-4
SEPT4	O43236	305	339	141	414	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT4	O43236	20	119	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SEPT4	O43236	20	119	118	118	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SEPT4	O43236	305	339	325	325	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:24275569;Dbxref=PMID:18318008,PMID:24275569
SEPT4	O43236	20	119	1	147	Alternative sequence	ID=VSP_038302;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEPT4	O43236	20	119	1	20	Alternative sequence	ID=VSP_006050;Note=In isoform 2 and isoform ARTS. MDRSLGWQGNSVPEDRTEAG->M;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11146656,ECO:0000303|PubMed:11167005,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11146656,PMID:11167005,PMID:14702039,PMID:15489334
SEPT4	O43236	20	119	1	20	Alternative sequence	ID=VSP_038303;Note=In isoform 3. MDRSLGWQGNSVPEDRTEAG->MPGFYSVMTDEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEPT4	O43236	20	119	1	20	Alternative sequence	ID=VSP_038304;Note=In isoform 4. MDRSLGWQGNSVPEDRTEAG->MRSSPALFSSRAAPQKPRKEGSQAAGLLVFSDSLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SEPT4	O43236	305	339	294	478	Alternative sequence	ID=VSP_038306;Note=In isoform ARTS. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11146656;Dbxref=PMID:11146656
SEPT4	O43236	305	339	311	311	Natural variant	ID=VAR_051935;Note=E->V;Dbxref=dbSNP:rs17741424
PSAT1	Q9Y617	247	289	1	370	Chain	ID=PRO_0000150135;Note=Phosphoserine aminotransferase
PSAT1	Q9Y617	290	335	1	370	Chain	ID=PRO_0000150135;Note=Phosphoserine aminotransferase
PSAT1	Q9Y617	247	289	269	269	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PSAT1	Q9Y617	290	335	318	318	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PSAT1	Q9Y617	290	335	323	323	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PSAT1	Q9Y617	290	335	331	331	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSAT1	Q9Y617	290	335	333	333	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
PSAT1	Q9Y617	290	335	291	336	Alternative sequence	ID=VSP_000237;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12633500,ECO:0000303|PubMed:15489334;Dbxref=PMID:12633500,PMID:15489334
PSAT1	Q9Y617	247	289	245	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	247	289	263	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	247	289	288	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	290	335	288	290	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	290	335	295	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	290	335	300	309	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	290	335	314	326	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
PSAT1	Q9Y617	290	335	329	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E77
SCAF1	Q9H7N4	159	1105	1	1312	Chain	ID=PRO_0000299406;Note=Splicing factor%2C arginine/serine-rich 19
SCAF1	Q9H7N4	1133	1206	1	1312	Chain	ID=PRO_0000299406;Note=Splicing factor%2C arginine/serine-rich 19
SCAF1	Q9H7N4	1133	1206	1187	1312	Region	Note=Necessary for interaction with the CTD domain of POLR2A
SCAF1	Q9H7N4	159	1105	184	267	Compositional bias	Note=Pro-rich
SCAF1	Q9H7N4	159	1105	191	207	Compositional bias	Note=Ser-rich
SCAF1	Q9H7N4	159	1105	268	288	Compositional bias	Note=Glu-rich
SCAF1	Q9H7N4	159	1105	380	441	Compositional bias	Note=Pro-rich
SCAF1	Q9H7N4	159	1105	534	828	Compositional bias	Note=Ser-rich
SCAF1	Q9H7N4	159	1105	556	654	Compositional bias	Note=Arg-rich
SCAF1	Q9H7N4	159	1105	896	926	Compositional bias	Note=Lys-rich
SCAF1	Q9H7N4	159	1105	1009	1039	Compositional bias	Note=Glu-rich
SCAF1	Q9H7N4	159	1105	239	239	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	335	335	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SCAF1	Q9H7N4	159	1105	448	448	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SCAF1	Q9H7N4	159	1105	453	453	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SCAF1	Q9H7N4	159	1105	498	498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	500	500	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	526	526	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
SCAF1	Q9H7N4	159	1105	548	548	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
SCAF1	Q9H7N4	159	1105	612	612	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF1	Q9H7N4	159	1105	614	614	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF1	Q9H7N4	159	1105	706	706	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF1	Q9H7N4	159	1105	719	719	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF1	Q9H7N4	159	1105	725	725	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF1	Q9H7N4	159	1105	732	732	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SCAF1	Q9H7N4	159	1105	734	734	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	738	738	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	872	872	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SCAF1	Q9H7N4	159	1105	874	874	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	929	929	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF1	Q9H7N4	159	1105	936	936	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SCAF1	Q9H7N4	159	1105	963	963	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U4C3
SCAF1	Q9H7N4	159	1105	965	965	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
SCAF1	Q9H7N4	159	1105	976	976	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
SCAF1	Q9H7N4	159	1105	989	989	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
SCAF1	Q9H7N4	159	1105	992	992	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U4C3
SCAF1	Q9H7N4	159	1105	1001	1001	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
SCAF1	Q9H7N4	159	1105	865	865	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SCAF1	Q9H7N4	159	1105	895	895	Natural variant	ID=VAR_052235;Note=T->A;Dbxref=dbSNP:rs3745470
SCAF1	Q9H7N4	1133	1206	1146	1146	Natural variant	ID=VAR_052236;Note=M->T;Dbxref=dbSNP:rs2304208
SCAF1	Q9H7N4	159	1105	420	420	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SCAF1	Q9H7N4	159	1105	420	420	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHF	Q7M4L6	217	264	1	423	Chain	ID=PRO_0000322558;Note=SH2 domain-containing adapter protein F
SHF	Q7M4L6	217	264	218	264	Alternative sequence	ID=VSP_052699;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHC2	P98077	391	436	1	582	Chain	ID=PRO_0000097732;Note=SHC-transforming protein 2
SHC2	P98077	391	436	330	486	Region	Note=CH1
SHC2	P98077	391	436	414	414	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12006576;Dbxref=PMID:12006576
SNX29	Q8TEQ0	594	633	1	813	Chain	ID=PRO_0000297565;Note=Sorting nexin-29
SNX29	Q8TEQ0	679	726	1	813	Chain	ID=PRO_0000297565;Note=Sorting nexin-29
SNX29	Q8TEQ0	679	726	656	779	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SLCO2A1	Q92959	132	208	1	643	Chain	ID=PRO_0000191058;Note=Solute carrier organic anion transporter family member 2A1
SLCO2A1	Q92959	132	208	124	167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2A1	Q92959	132	208	168	196	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2A1	Q92959	132	208	197	215	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2A1	Q92959	132	208	134	134	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO2A1	Q92959	132	208	181	181	Natural variant	ID=VAR_068638;Note=In PHOAR2. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22553128;Dbxref=PMID:22553128
SLCO2A1	Q92959	132	208	181	181	Natural variant	ID=VAR_068639;Note=In PHOAR2. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22553128;Dbxref=PMID:22553128
SLCO2A1	Q92959	132	208	204	204	Natural variant	ID=VAR_068640;Note=In PHOAR2. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22553128;Dbxref=dbSNP:rs555934769,PMID:22553128
SLCO2A1	Q92959	132	208	181	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MRR
SP3	Q02447	52	93	1	781	Chain	ID=PRO_0000047141;Note=Transcription factor Sp3
SP3	Q02447	52	93	44	100	Compositional bias	Note=Ala-rich
SP3	Q02447	52	93	73	73	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
SP3	Q02447	52	93	1	302	Alternative sequence	ID=VSP_026698;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SP3	Q02447	52	93	1	285	Alternative sequence	ID=VSP_026699;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SP3	Q02447	52	93	1	69	Alternative sequence	ID=VSP_026700;Note=In isoform 5. MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSKI->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12297010;Dbxref=PMID:12297010
SP3	Q02447	52	93	53	93	Alternative sequence	ID=VSP_026702;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15474306;Dbxref=PMID:15474306
SP3	Q02447	52	93	69	69	Sequence conflict	Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
SP3	Q02447	52	93	71	71	Sequence conflict	Note=P->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM135	Q86UB9	90	120	1	458	Chain	ID=PRO_0000284622;Note=Transmembrane protein 135
TMEM135	Q86UB9	132	154	1	458	Chain	ID=PRO_0000284622;Note=Transmembrane protein 135
TMEM135	Q86UB9	170	183	1	458	Chain	ID=PRO_0000284622;Note=Transmembrane protein 135
TMEM135	Q86UB9	184	232	1	458	Chain	ID=PRO_0000284622;Note=Transmembrane protein 135
TMEM135	Q86UB9	90	120	96	116	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM135	Q86UB9	132	154	149	169	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM135	Q86UB9	132	154	133	154	Alternative sequence	ID=VSP_024579;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
TMEM135	Q86UB9	184	232	193	193	Natural variant	ID=VAR_031787;Note=P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854687,PMID:15489334
TMEM135	Q86UB9	184	232	218	218	Natural variant	ID=VAR_031788;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs2276102,PMID:14702039,PMID:15489334,PMID:17974005
TMEM14B	Q9NUH8	33	67	1	114	Chain	ID=PRO_0000221172;Note=Transmembrane protein 14B
TMEM14B	Q9NUH8	33	67	34	54	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM14B	Q9NUH8	33	67	60	80	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM14B	Q9NUH8	33	67	34	67	Alternative sequence	ID=VSP_046899;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM14B	Q9NUH8	33	67	37	37	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM14B	Q9NUH8	33	67	42	42	Sequence conflict	Note=G->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM181	Q9P2C4	301	328	1	612	Chain	ID=PRO_0000239661;Note=Transmembrane protein 181
TMEM181	Q9P2C4	301	328	312	332	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM182	Q6ZP80	110	156	27	229	Chain	ID=PRO_0000290226;Note=Transmembrane protein 182
TMEM182	Q6ZP80	110	156	27	114	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM182	Q6ZP80	110	156	115	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM182	Q6ZP80	110	156	136	153	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM182	Q6ZP80	110	156	154	174	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM182	Q6ZP80	110	156	1	119	Alternative sequence	ID=VSP_026134;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPG21	Q9NZD8	187	223	1	308	Chain	ID=PRO_0000227980;Note=Maspardin
SPG21	Q9NZD8	75	102	1	308	Chain	ID=PRO_0000227980;Note=Maspardin
SPG21	Q9NZD8	21	75	1	308	Chain	ID=PRO_0000227980;Note=Maspardin
SPG21	Q9NZD8	187	223	1	308	Chain	ID=PRO_0000227980;Note=Maspardin
SPG21	Q9NZD8	75	102	1	308	Chain	ID=PRO_0000227980;Note=Maspardin
SPG21	Q9NZD8	21	75	1	308	Chain	ID=PRO_0000227980;Note=Maspardin
SPG21	Q9NZD8	75	102	87	159	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPG21	Q9NZD8	75	102	87	159	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPG21	Q9NZD8	75	102	76	102	Alternative sequence	ID=VSP_041512;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPG21	Q9NZD8	75	102	76	102	Alternative sequence	ID=VSP_041512;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPG21	Q9NZD8	21	75	40	40	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPG21	Q9NZD8	21	75	40	40	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPG21	Q9NZD8	21	75	58	58	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPG21	Q9NZD8	21	75	58	58	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPG21	Q9NZD8	187	223	210	210	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPG21	Q9NZD8	187	223	210	210	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM192	Q8IY95	146	191	1	271	Chain	ID=PRO_0000311267;Note=Transmembrane protein 192
TMEM192	Q8IY95	146	191	139	159	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM192	Q8IY95	146	191	160	171	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM192	Q8IY95	146	191	172	192	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM192	Q8IY95	146	191	163	163	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM192	Q8IY95	146	191	190	190	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAS2	O75934	86	139	2	225	Chain	ID=PRO_0000064861;Note=Pre-mRNA-splicing factor SPF27
BCAS2	O75934	86	139	138	222	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BCAS2	O75934	86	139	94	94	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BCAS2	O75934	86	139	139	139	Natural variant	ID=VAR_035799;Note=In a colorectal cancer sample%3B somatic mutation. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1197668726,PMID:16959974
BCAS2	O75934	86	139	89	89	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	1	384	Chain	ID=PRO_0000181357;Note=Sphingosine kinase 1
SPHK1	Q9NYA1	3	54	1	384	Chain	ID=PRO_0000181357;Note=Sphingosine kinase 1
SPHK1	Q9NYA1	3	54	1	384	Chain	ID=PRO_0000181357;Note=Sphingosine kinase 1
SPHK1	Q9NYA1	3	54	12	159	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
SPHK1	Q9NYA1	3	54	12	159	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
SPHK1	Q9NYA1	3	54	12	159	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
SPHK1	Q9NYA1	3	54	22	24	Nucleotide binding	Note=ATP
SPHK1	Q9NYA1	3	54	22	24	Nucleotide binding	Note=ATP
SPHK1	Q9NYA1	3	54	22	24	Nucleotide binding	Note=ATP
SPHK1	Q9NYA1	3	54	54	58	Nucleotide binding	Note=ATP
SPHK1	Q9NYA1	3	54	54	58	Nucleotide binding	Note=ATP
SPHK1	Q9NYA1	3	54	54	58	Nucleotide binding	Note=ATP
SPHK1	Q9NYA1	3	54	3	3	Alternative sequence	ID=VSP_047078;Note=In isoform 3. P->PVVGCGRGLFGFVFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPHK1	Q9NYA1	3	54	3	3	Alternative sequence	ID=VSP_047078;Note=In isoform 3. P->PVVGCGRGLFGFVFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPHK1	Q9NYA1	3	54	3	3	Alternative sequence	ID=VSP_047078;Note=In isoform 3. P->PVVGCGRGLFGFVFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SPHK1	Q9NYA1	3	54	6	6	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	6	6	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	6	6	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	11	15	Sequence conflict	Note=LPRPC->ARL;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	11	15	Sequence conflict	Note=LPRPC->ARL;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	11	15	Sequence conflict	Note=LPRPC->ARL;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPHK1	Q9NYA1	3	54	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	26	29	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	26	29	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	26	29	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	30	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	30	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	30	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	39	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	39	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	39	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPHK1	Q9NYA1	3	54	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V24
SPICE1	Q8N0Z3	385	429	1	855	Chain	ID=PRO_0000282413;Note=Spindle and centriole-associated protein 1
SPICE1	Q8N0Z3	33	49	1	855	Chain	ID=PRO_0000282413;Note=Spindle and centriole-associated protein 1
SPICE1	Q8N0Z3	385	429	325	437	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPIDR	Q14159	515	561	1	915	Chain	ID=PRO_0000251720;Note=DNA repair-scaffolding protein
SPIDR	Q14159	591	639	1	915	Chain	ID=PRO_0000251720;Note=DNA repair-scaffolding protein
SPIDR	Q14159	639	659	1	915	Chain	ID=PRO_0000251720;Note=DNA repair-scaffolding protein
SPIDR	Q14159	850	868	1	915	Chain	ID=PRO_0000251720;Note=DNA repair-scaffolding protein
SPIDR	Q14159	850	868	851	915	Alternative sequence	ID=VSP_056654;Note=In isoform 3. LLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIGLEEIELLSAGGASAEH->VGARPEHARTPSSLQHSEELRSEECPRKGSGVVKLFCPVRNRPPDQLHWIGGNRASECRRGLCRTLAVAAGSVNFAMWLQGWWWWW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPIN1	Q9Y657	118	196	1	262	Chain	ID=PRO_0000181367;Note=Spindlin-1
SPIN1	Q9Y657	118	196	132	193	Region	Note=Tudor-like domain 2
SPIN1	Q9Y657	118	196	142	142	Region	Note=Histone H3K4me3 and H3R8me2a binding
SPIN1	Q9Y657	118	196	173	173	Binding site	Note=Histone H3K4me3 and H3R8me2a
SPIN1	Q9Y657	118	196	180	180	Binding site	Note=Histone H3K4me3 and H3R8me2a
SPIN1	Q9Y657	118	196	184	184	Binding site	Note=Histone H3K4me3 and H3R8me2a
SPIN1	Q9Y657	118	196	124	124	Modified residue	Note=Phosphoserine%3B by AURKA;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:22258766;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:22258766
SPIN1	Q9Y657	118	196	124	124	Mutagenesis	Note=Impaired phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22258766;Dbxref=PMID:22258766
SPIN1	Q9Y657	118	196	141	141	Mutagenesis	Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Impaired ability to activate expression of pre-rRNA. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21960006,ECO:0000269|PubMed:24589551;Dbxref=PMID:21960006,PMID:24589551
SPIN1	Q9Y657	118	196	142	142	Mutagenesis	Note=Impaired binding to histone H3K4me3 and H3R8me2a. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551
SPIN1	Q9Y657	118	196	170	170	Mutagenesis	Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Impaired ability to activate expression of pre-rRNA. Y->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21960006,ECO:0000269|PubMed:24589551;Dbxref=PMID:21960006,PMID:24589551
SPIN1	Q9Y657	118	196	177	177	Mutagenesis	Note=Impaired binding to histone H3K4me3 and H3R8me2a. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551
SPIN1	Q9Y657	118	196	184	184	Mutagenesis	Note=Impaired binding to histone H3K4me3 and H3R8me2a. D->A%2CR;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23077255,ECO:0000269|PubMed:24589551;Dbxref=PMID:23077255,PMID:24589551
SPIN1	Q9Y657	118	196	189	189	Mutagenesis	Note=Impaired binding to histone H3K4me3. D->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23077255;Dbxref=PMID:23077255
SPIN1	Q9Y657	118	196	126	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	136	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NS2
SPIN1	Q9Y657	118	196	148	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	160	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	166	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	173	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	181	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SPIN1	Q9Y657	118	196	190	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MZG
SH3RF1	Q7Z6J0	449	505	1	888	Chain	ID=PRO_0000334151;Note=E3 ubiquitin-protein ligase SH3RF1
SH3RF1	Q7Z6J0	356	393	1	888	Chain	ID=PRO_0000334151;Note=E3 ubiquitin-protein ligase SH3RF1
SH3RF1	Q7Z6J0	255	356	1	888	Chain	ID=PRO_0000334151;Note=E3 ubiquitin-protein ligase SH3RF1
SH3RF1	Q7Z6J0	223	255	1	888	Chain	ID=PRO_0000334151;Note=E3 ubiquitin-protein ligase SH3RF1
SH3RF1	Q7Z6J0	255	356	196	259	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF1	Q7Z6J0	223	255	196	259	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF1	Q7Z6J0	449	505	445	506	Domain	Note=SH3 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF1	Q7Z6J0	356	393	292	362	Region	Note=Interaction with RAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164
SH3RF1	Q7Z6J0	255	356	292	362	Region	Note=Interaction with RAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164
SH3RF1	Q7Z6J0	449	505	440	543	Region	Note=Interaction with AKT2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SH3RF1	Q7Z6J0	255	356	304	304	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:17535800;Dbxref=PMID:20068231,PMID:23186163,PMID:17535800
SH3RF1	Q7Z6J0	449	505	442	888	Alternative sequence	ID=VSP_033623;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3RF1	Q7Z6J0	255	356	304	304	Mutagenesis	Note=Decreased level of phosphorylation and no change in the ability to induce apoptosis. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17535800;Dbxref=PMID:17535800
SH3RF1	Q7Z6J0	255	356	304	304	Mutagenesis	Note=Decreased level of phosphorylation and Rac-binding ability and important loss of the ability to induce apoptosis. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17535800;Dbxref=PMID:17535800
SH3RF1	Q7Z6J0	255	356	304	304	Mutagenesis	Note=Decreased Rac-binding ability. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17535800;Dbxref=PMID:17535800
SGTA	O43765	246	275	1	313	Chain	ID=PRO_0000106365;Note=Small glutamine-rich tetratricopeptide repeat-containing protein alpha
SGTA	O43765	246	275	275	287	Compositional bias	Note=Gln-rich
SH3GL1	Q99961	62	110	1	368	Chain	ID=PRO_0000146744;Note=Endophilin-A2
SH3GL1	Q99961	62	110	18	249	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GL1	Q99961	62	110	60	87	Region	Note=Required for dimerization upon membrane association;Ontology_term=ECO:0000250;evidence=ECO:0000250
SH3GL1	Q99961	62	110	63	110	Alternative sequence	ID=VSP_045837;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SH3GL1	Q99961	62	110	80	143	Alternative sequence	ID=VSP_047037;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KNSTRN	Q9Y448	146	161	1	316	Chain	ID=PRO_0000274512;Note=Small kinetochore-associated protein
KNSTRN	Q9Y448	146	161	159	316	Region	Note=Interaction with SPAG5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21402792;Dbxref=PMID:21402792
SKA1	Q96BD8	104	149	2	255	Chain	ID=PRO_0000273155;Note=Spindle and kinetochore-associated protein 1
SKA1	Q96BD8	104	149	2	255	Chain	ID=PRO_0000273155;Note=Spindle and kinetochore-associated protein 1
SKA1	Q96BD8	104	149	132	255	Region	Note=Microtubule binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23085020;Dbxref=PMID:23085020
SKA1	Q96BD8	104	149	132	255	Region	Note=Microtubule binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23085020;Dbxref=PMID:23085020
SKA1	Q96BD8	104	149	104	150	Alternative sequence	ID=VSP_037250;Note=In isoform 2. CVKGSDLDPEEPIKVEEPEPVKKPPKEQRSIKEMPFITCDEFNGVPS->W;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SKA1	Q96BD8	104	149	104	150	Alternative sequence	ID=VSP_037250;Note=In isoform 2. CVKGSDLDPEEPIKVEEPEPVKKPPKEQRSIKEMPFITCDEFNGVPS->W;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SKA1	Q96BD8	104	149	142	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9Y
SKA1	Q96BD8	104	149	142	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9Y
SLBP	Q14493	160	209	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	94	113	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	59	93	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	20	58	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	160	209	129	198	Region	Note=RNA-binding
SLBP	Q14493	20	58	31	34	Motif	Note=Nuclear localization signal NLS1
SLBP	Q14493	94	113	96	99	Motif	Note=Nuclear localization signal NLS2
SLBP	Q14493	20	58	20	20	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
SLBP	Q14493	20	58	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
SLBP	Q14493	59	93	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLBP	Q14493	59	93	61	61	Modified residue	Note=Phosphothreonine%3B by CK2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
SLBP	Q14493	59	93	62	62	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:23186163,PMID:12588979,PMID:18490441
SLBP	Q14493	160	209	171	171	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:22439849;Dbxref=PMID:23186163,PMID:22439849
SLBP	Q14493	160	209	182	182	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SLBP	Q14493	94	113	98	98	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SLBP	Q14493	20	58	20	58	Alternative sequence	ID=VSP_042164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLBP	Q14493	20	58	31	34	Mutagenesis	Note=Reduces interaction with the importin alpha/importin beta receptor. Abolishes interaction with the importin alpha/importin beta receptor%3B when associated with A-96%3B A-97%3B A-98 and A-99 or with A-241%3B A-242%3B A-243 and A-244. RKRR->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15829567;Dbxref=PMID:15829567
SLBP	Q14493	59	93	59	63	Mutagenesis	Note=Does not increase its stability at the end of the S phase and through G2 and mitosis. SFTTP->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18490441;Dbxref=PMID:18490441
SLBP	Q14493	59	93	59	59	Mutagenesis	Note=Does not increase its stability at the end of the S phase and through G2 and mitosis. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588979;Dbxref=PMID:12588979
SLBP	Q14493	59	93	61	61	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. Active in histone pre-mRNA processing during the G2 phase. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
SLBP	Q14493	59	93	62	62	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
SLBP	Q14493	59	93	63	63	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588979;Dbxref=PMID:12588979
SLBP	Q14493	94	113	96	99	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. Inhibits phosphorylation of T-62. Localizes in the nucleus. Reduces interaction with the importin alpha/importin beta receptor. Abolishes interaction with the importin alpha/importin beta receptor%3B when associated with A-31%3B A-32%3B A-33 and A-34 or with A-241%3B A-242%3B A-243 and A-244. KRKL->AAAA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:15829567,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:15829567,PMID:18490441
SLBP	Q14493	160	209	165	167	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QOZ
SLBP	Q14493	160	209	180	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QOZ
SLBP	Q14493	160	209	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QOZ
SMC6	Q96SB8	315	364	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	242	282	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	181	208	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	315	364	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	242	282	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	181	208	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	315	364	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	242	282	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	181	208	1	1091	Chain	ID=PRO_0000270956;Note=Structural maintenance of chromosomes protein 6
SMC6	Q96SB8	315	364	226	451	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC6	Q96SB8	242	282	226	451	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC6	Q96SB8	315	364	226	451	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC6	Q96SB8	242	282	226	451	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC6	Q96SB8	315	364	226	451	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC6	Q96SB8	242	282	226	451	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SMC6	Q96SB8	242	282	268	268	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMC6	Q96SB8	242	282	268	268	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SMC6	Q96SB8	242	282	268	268	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SNX22	Q96L94	25	53	1	193	Chain	ID=PRO_0000213871;Note=Sorting nexin-22
SNX22	Q96L94	120	130	1	193	Chain	ID=PRO_0000213871;Note=Sorting nexin-22
SNX22	Q96L94	25	53	1	118	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX22	Q96L94	25	53	43	43	Binding site	Note=Phosphatidylinositol 3-phosphate
SNX22	Q96L94	25	53	45	45	Binding site	Note=Phosphatidylinositol 3-phosphate%3B via amide nitrogen and carbonyl oxygen
SNX22	Q96L94	120	130	121	193	Alternative sequence	ID=VSP_056595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNX22	Q96L94	25	53	26	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ETT
SNX22	Q96L94	25	53	36	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ETT
SNX22	Q96L94	25	53	44	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ETT
SNX24	Q9Y343	48	83	1	169	Chain	ID=PRO_0000213872;Note=Sorting nexin-24
SNX24	Q9Y343	48	83	1	125	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX24	Q9Y343	48	83	61	61	Binding site	Note=Phosphatidylinositol 3-phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250
SNX24	Q9Y343	48	83	74	74	Binding site	Note=Phosphatidylinositol 3-phosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250
SNX24	Q9Y343	48	83	39	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AZ9
SNX24	Q9Y343	48	83	50	52	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AZ9
SNX24	Q9Y343	48	83	68	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AZ9
SIGLEC1	Q9BZZ2	1530	1631	20	1709	Chain	ID=PRO_0000014968;Note=Sialoadhesin
SIGLEC1	Q9BZZ2	894	981	20	1709	Chain	ID=PRO_0000014968;Note=Sialoadhesin
SIGLEC1	Q9BZZ2	707	793	20	1709	Chain	ID=PRO_0000014968;Note=Sialoadhesin
SIGLEC1	Q9BZZ2	509	595	20	1709	Chain	ID=PRO_0000014968;Note=Sialoadhesin
SIGLEC1	Q9BZZ2	409	509	20	1709	Chain	ID=PRO_0000014968;Note=Sialoadhesin
SIGLEC1	Q9BZZ2	324	409	20	1709	Chain	ID=PRO_0000014968;Note=Sialoadhesin
SIGLEC1	Q9BZZ2	1530	1631	20	1641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	894	981	20	1641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	707	793	20	1641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	509	595	20	1641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	409	509	20	1641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	324	409	20	1641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	324	409	326	405	Domain	Note=Ig-like C2-type 3
SIGLEC1	Q9BZZ2	409	509	411	507	Domain	Note=Ig-like C2-type 4
SIGLEC1	Q9BZZ2	509	595	511	593	Domain	Note=Ig-like C2-type 5
SIGLEC1	Q9BZZ2	707	793	708	785	Domain	Note=Ig-like C2-type 7
SIGLEC1	Q9BZZ2	894	981	799	894	Domain	Note=Ig-like C2-type 8
SIGLEC1	Q9BZZ2	894	981	898	977	Domain	Note=Ig-like C2-type 9
SIGLEC1	Q9BZZ2	1530	1631	1536	1631	Domain	Note=Ig-like C2-type 16
SIGLEC1	Q9BZZ2	324	409	339	339	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	409	509	499	499	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	707	793	726	726	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	707	793	730	730	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	707	793	741	741	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC1	Q9BZZ2	324	409	346	390	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC1	Q9BZZ2	409	509	433	491	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC1	Q9BZZ2	509	595	531	575	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC1	Q9BZZ2	707	793	729	774	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC1	Q9BZZ2	894	981	916	960	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC1	Q9BZZ2	1530	1631	1554	1613	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC1	Q9BZZ2	409	509	464	464	Natural variant	ID=VAR_049944;Note=R->H;Dbxref=dbSNP:rs34924243
SIGLEC1	Q9BZZ2	894	981	919	919	Natural variant	ID=VAR_014137;Note=H->P;Dbxref=dbSNP:rs709012
SIGLEC1	Q9BZZ2	894	981	974	974	Natural variant	ID=VAR_021926;Note=A->V;Dbxref=dbSNP:rs3746638
SLCO5A1	Q9H2Y9	419	474	1	848	Chain	ID=PRO_0000191070;Note=Solute carrier organic anion transporter family member 5A1
SLCO5A1	Q9H2Y9	419	474	370	427	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO5A1	Q9H2Y9	419	474	428	449	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO5A1	Q9H2Y9	419	474	450	469	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO5A1	Q9H2Y9	419	474	470	493	Transmembrane	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO5A1	Q9H2Y9	419	474	469	469	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLCO5A1	Q9H2Y9	419	474	420	474	Alternative sequence	ID=VSP_045498;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLCO5A1	Q9H2Y9	419	474	457	457	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
SORCS2	Q96PQ0	216	271	51	1159	Chain	ID=PRO_0000033172;Note=VPS10 domain-containing receptor SorCS2
SORCS2	Q96PQ0	708	750	51	1159	Chain	ID=PRO_0000033172;Note=VPS10 domain-containing receptor SorCS2
SORCS2	Q96PQ0	216	271	51	1078	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORCS2	Q96PQ0	708	750	51	1078	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORCS2	Q96PQ0	216	271	232	243	Repeat	Note=BNR 2
SORCS2	Q96PQ0	708	750	745	745	Natural variant	ID=VAR_060111;Note=T->I;Dbxref=dbSNP:rs16840899
SORCS2	Q96PQ0	708	750	716	716	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPA17	Q15506	75	104	1	151	Chain	ID=PRO_0000181340;Note=Sperm surface protein Sp17
SPA17	Q15506	75	104	1	151	Chain	ID=PRO_0000181340;Note=Sperm surface protein Sp17
SPCS1	Q9Y6A9	32	61	1	102	Chain	ID=PRO_0000215154;Note=Signal peptidase complex subunit 1
SPCS1	Q9Y6A9	32	61	27	47	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPCS1	Q9Y6A9	32	61	48	48	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPCS1	Q9Y6A9	32	61	49	69	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPCS1	Q9Y6A9	32	61	61	61	Sequence conflict	Note=L->LAQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPC25	Q9HBM1	150	183	1	224	Chain	ID=PRO_0000249565;Note=Kinetochore protein Spc25
SPC25	Q9HBM1	44	66	1	224	Chain	ID=PRO_0000249565;Note=Kinetochore protein Spc25
SPC25	Q9HBM1	44	66	1	144	Region	Note=Interaction with the N-terminus of SPBC24
SPC25	Q9HBM1	44	66	1	56	Region	Note=Interaction with the NDC80-NUF2 subcomplex
SPC25	Q9HBM1	150	183	145	224	Region	Note=Interaction with the C-terminus of SPBC24
SPC25	Q9HBM1	44	66	61	142	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SPC25	Q9HBM1	150	183	154	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VE7
SPC25	Q9HBM1	150	183	171	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VE7
SPC25	Q9HBM1	150	183	177	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VE7
SDK2	Q58EX2	1768	1822	21	2172	Chain	ID=PRO_0000226978;Note=Protein sidekick-2
SDK2	Q58EX2	1722	1768	21	2172	Chain	ID=PRO_0000226978;Note=Protein sidekick-2
SDK2	Q58EX2	1568	1587	21	2172	Chain	ID=PRO_0000226978;Note=Protein sidekick-2
SDK2	Q58EX2	1768	1822	21	1932	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK2	Q58EX2	1722	1768	21	1932	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK2	Q58EX2	1568	1587	21	1932	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SDK2	Q58EX2	1568	1587	1504	1621	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
SDK2	Q58EX2	1722	1768	1626	1722	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
SDK2	Q58EX2	1768	1822	1726	1821	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
SDK2	Q58EX2	1722	1768	1726	1821	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
SDK2	Q58EX2	1568	1587	1569	1588	Alternative sequence	ID=VSP_017522;Note=In isoform 3. SMYSMRNLSRPSLTQYELDN->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SEPT12	Q8IYM1	125	170	1	358	Chain	ID=PRO_0000312860;Note=Septin-12
SEPT12	Q8IYM1	125	170	46	317	Domain	Note=Septin-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01056
SEPT12	Q8IYM1	125	170	46	319	Region	Note=Interaction with SEPT7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25588830;Dbxref=PMID:25588830
SEPT12	Q8IYM1	125	170	125	170	Alternative sequence	ID=VSP_029918;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17685441,ECO:0000303|PubMed:18047794;Dbxref=PMID:17685441,PMID:18047794
FAP	Q12884	483	516	1	760	Chain	ID=PRO_0000122424;Note=Prolyl endopeptidase FAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAP	Q12884	334	349	1	760	Chain	ID=PRO_0000122424;Note=Prolyl endopeptidase FAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAP	Q12884	95	120	1	760	Chain	ID=PRO_0000122424;Note=Prolyl endopeptidase FAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAP	Q12884	30	63	1	760	Chain	ID=PRO_0000122424;Note=Prolyl endopeptidase FAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
FAP	Q12884	483	516	24	760	Chain	ID=PRO_0000430643;Note=Antiplasmin-cleaving enzyme FAP%2C soluble form;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	334	349	24	760	Chain	ID=PRO_0000430643;Note=Antiplasmin-cleaving enzyme FAP%2C soluble form;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	95	120	24	760	Chain	ID=PRO_0000430643;Note=Antiplasmin-cleaving enzyme FAP%2C soluble form;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	30	63	24	760	Chain	ID=PRO_0000430643;Note=Antiplasmin-cleaving enzyme FAP%2C soluble form;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	483	516	26	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	334	349	26	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	95	120	26	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	30	63	26	760	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:14751930;Dbxref=PMID:14751930
FAP	Q12884	30	63	49	49	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00498,ECO:0000269|PubMed:15809306;Dbxref=PMID:15809306
FAP	Q12884	95	120	99	99	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00498,ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
FAP	Q12884	483	516	1	521	Alternative sequence	ID=VSP_005367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644713;Dbxref=PMID:10644713
FAP	Q12884	334	349	1	521	Alternative sequence	ID=VSP_005367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644713;Dbxref=PMID:10644713
FAP	Q12884	95	120	1	521	Alternative sequence	ID=VSP_005367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644713;Dbxref=PMID:10644713
FAP	Q12884	30	63	1	521	Alternative sequence	ID=VSP_005367;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644713;Dbxref=PMID:10644713
FAP	Q12884	30	63	44	49	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	30	63	50	52	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	30	63	60	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	95	120	92	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	95	120	97	99	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	95	120	101	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	95	120	109	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	334	349	334	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	334	349	337	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	334	349	343	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	334	349	347	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	483	516	484	489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	483	516	492	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	483	516	505	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
FAP	Q12884	483	516	516	524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z68
SETD6	Q8TBK2	159	223	1	473	Chain	ID=PRO_0000281889;Note=N-lysine methyltransferase SETD6
SETD6	Q8TBK2	159	223	60	286	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SETD6	Q8TBK2	159	223	185	185	Natural variant	ID=VAR_064590;Note=R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852020,PMID:15489334
SETD6	Q8TBK2	159	223	206	206	Natural variant	ID=VAR_064591;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852021,PMID:15489334
SETD6	Q8TBK2	159	223	161	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QXY
SETD6	Q8TBK2	159	223	173	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QXY
SETD6	Q8TBK2	159	223	192	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QXY
SETD6	Q8TBK2	159	223	200	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QXY
SETD6	Q8TBK2	159	223	205	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QXY
SETD6	Q8TBK2	159	223	210	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QXY
SETDB2	Q96T68	102	289	1	719	Chain	ID=PRO_0000186088;Note=Histone-lysine N-methyltransferase SETDB2
SETDB2	Q96T68	290	328	1	719	Chain	ID=PRO_0000186088;Note=Histone-lysine N-methyltransferase SETDB2
SETDB2	Q96T68	102	289	157	229	Domain	Note=MBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00338
SETDB2	Q96T68	290	328	291	364	Domain	Note=Pre-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00157
SETDB2	Q96T68	290	328	293	293	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	290	328	293	293	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	290	328	295	295	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	290	328	299	299	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	290	328	299	299	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	290	328	305	305	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	290	328	307	307	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SETDB2	Q96T68	102	289	117	117	Natural variant	ID=VAR_031282;Note=E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11306461,ECO:0000269|PubMed:12754510;Dbxref=dbSNP:rs7998427,PMID:11306461,PMID:12754510
SF3B2	Q13435	166	183	1	895	Chain	ID=PRO_0000174328;Note=Splicing factor 3B subunit 2
SF3B2	Q13435	593	623	1	895	Chain	ID=PRO_0000174328;Note=Splicing factor 3B subunit 2
SF3B2	Q13435	623	659	1	895	Chain	ID=PRO_0000174328;Note=Splicing factor 3B subunit 2
SF3B2	Q13435	659	695	1	895	Chain	ID=PRO_0000174328;Note=Splicing factor 3B subunit 2
SF3B2	Q13435	166	183	140	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SF3B2	Q13435	593	623	602	602	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFT2D1	Q8WV19	137	146	1	159	Chain	ID=PRO_0000238607;Note=Vesicle transport protein SFT2A
SFT2D1	Q8WV19	105	117	1	159	Chain	ID=PRO_0000238607;Note=Vesicle transport protein SFT2A
SFT2D1	Q8WV19	105	117	98	118	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFT2D1	Q8WV19	137	146	123	143	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFT2D1	Q8WV19	137	146	144	159	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFT2D1	Q8WV19	105	117	109	109	Natural variant	ID=VAR_034492;Note=I->V;Dbxref=dbSNP:rs11551053
SGCD	Q92629	63	97	1	289	Chain	ID=PRO_0000175245;Note=Delta-sarcoglycan
SGCD	Q92629	126	166	1	289	Chain	ID=PRO_0000175245;Note=Delta-sarcoglycan
SGCD	Q92629	63	97	57	289	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGCD	Q92629	126	166	57	289	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGCD	Q92629	63	97	96	96	Natural variant	ID=VAR_010429;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8842738;Dbxref=dbSNP:rs45559835,PMID:8842738
SGCD	Q92629	126	166	150	150	Natural variant	ID=VAR_013181;Note=In CMD1L. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10974018;Dbxref=dbSNP:rs121909298,PMID:10974018
SGSM3	Q96HU1	158	206	1	749	Chain	ID=PRO_0000307810;Note=Small G protein signaling modulator 3
SGSM3	Q96HU1	543	594	1	749	Chain	ID=PRO_0000307810;Note=Small G protein signaling modulator 3
SGSM3	Q96HU1	663	703	1	749	Chain	ID=PRO_0000307810;Note=Small G protein signaling modulator 3
SGSM3	Q96HU1	158	206	114	305	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
SGSM3	Q96HU1	543	594	555	718	Domain	Note=RUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00178
SGSM3	Q96HU1	663	703	555	718	Domain	Note=RUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00178
SH3D19	Q5HYK7	414	437	1	790	Chain	ID=PRO_0000318197;Note=SH3 domain-containing protein 19
SH3D19	Q5HYK7	231	267	1	790	Chain	ID=PRO_0000318197;Note=SH3 domain-containing protein 19
SH3D19	Q5HYK7	414	437	1	790	Chain	ID=PRO_0000318197;Note=SH3 domain-containing protein 19
SH3D19	Q5HYK7	231	267	1	790	Chain	ID=PRO_0000318197;Note=SH3 domain-containing protein 19
SH3D19	Q5HYK7	414	437	415	477	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3D19	Q5HYK7	414	437	415	477	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3D19	Q5HYK7	231	267	86	350	Compositional bias	Note=Pro-rich
SH3D19	Q5HYK7	231	267	86	350	Compositional bias	Note=Pro-rich
SH3D19	Q5HYK7	231	267	1	370	Alternative sequence	ID=VSP_031182;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3D19	Q5HYK7	231	267	1	370	Alternative sequence	ID=VSP_031182;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3D19	Q5HYK7	231	267	232	268	Alternative sequence	ID=VSP_031183;Note=In isoform 3. DPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKC->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3D19	Q5HYK7	231	267	232	268	Alternative sequence	ID=VSP_031183;Note=In isoform 3. DPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKC->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SH3D19	Q5HYK7	414	437	415	437	Alternative sequence	ID=VSP_031184;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SH3D19	Q5HYK7	414	437	415	437	Alternative sequence	ID=VSP_031184;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SH3D19	Q5HYK7	231	267	264	264	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3D19	Q5HYK7	231	267	264	264	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3D19	Q5HYK7	231	267	267	267	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3D19	Q5HYK7	231	267	267	267	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHD	Q96IW2	239	278	1	340	Chain	ID=PRO_0000246773;Note=SH2 domain-containing adapter protein D
SHD	Q96IW2	239	278	240	335	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
SHD	Q96IW2	239	278	270	270	Natural variant	ID=VAR_027044;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs888930,PMID:14702039
SIL1	Q9H173	151	215	32	461	Chain	ID=PRO_0000223354;Note=Nucleotide exchange factor SIL1
SIL1	Q9H173	151	215	32	461	Chain	ID=PRO_0000223354;Note=Nucleotide exchange factor SIL1
SIL1	Q9H173	151	215	1	256	Region	Note=Interaction with HSPA5 and localization to the endoplasmic reticulum;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIL1	Q9H173	151	215	1	256	Region	Note=Interaction with HSPA5 and localization to the endoplasmic reticulum;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIL1	Q9H173	151	215	193	193	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
SIL1	Q9H173	151	215	193	193	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
SLC9A7	Q96T83	538	557	1	725	Chain	ID=PRO_0000052363;Note=Sodium/hydrogen exchanger 7
SLC9A7	Q96T83	538	557	545	545	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BLV3
SFRP4	Q6FHJ7	175	197	19	346	Chain	ID=PRO_0000032550;Note=Secreted frizzled-related protein 4
SFRP4	Q6FHJ7	175	197	178	307	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
SFRP4	Q6FHJ7	175	197	194	194	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFT2D2	O95562	106	118	1	160	Chain	ID=PRO_0000238610;Note=Vesicle transport protein SFT2B
SFT2D2	O95562	106	118	99	119	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGCB	Q16585	207	251	1	318	Chain	ID=PRO_0000175242;Note=Beta-sarcoglycan
SGCB	Q16585	207	251	87	318	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SGCB	Q16585	207	251	97	314	Compositional bias	Note=Cys-rich
SGCB	Q16585	207	251	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
SFTPD	P35247	144	183	21	375	Chain	ID=PRO_0000017465;Note=Pulmonary surfactant-associated protein D
SFTPD	P35247	105	144	21	375	Chain	ID=PRO_0000017465;Note=Pulmonary surfactant-associated protein D
SFTPD	P35247	66	105	21	375	Chain	ID=PRO_0000017465;Note=Pulmonary surfactant-associated protein D
SFTPD	P35247	144	183	46	222	Domain	Note=Collagen-like
SFTPD	P35247	105	144	46	222	Domain	Note=Collagen-like
SFTPD	P35247	66	105	46	222	Domain	Note=Collagen-like
SFTPD	P35247	66	105	78	78	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250
SFTPD	P35247	66	105	87	87	Modified residue	Note=5-hydroxylysine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SFTPD	P35247	66	105	96	96	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250
SFTPD	P35247	66	105	99	99	Modified residue	Note=5-hydroxylysine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SFTPD	P35247	144	183	171	171	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250
SFTPD	P35247	144	183	177	177	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250
SFTPD	P35247	66	105	90	90	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFTPD	P35247	105	144	123	123	Natural variant	ID=VAR_020938;Note=L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19100526,ECO:0000269|Ref.4;Dbxref=dbSNP:rs17878336,PMID:19100526
SFTPD	P35247	144	183	180	180	Natural variant	ID=VAR_020939;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1339284,ECO:0000269|PubMed:19100526,ECO:0000269|Ref.3,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2243639,PMID:1339284,PMID:19100526
SFTPD	P35247	105	144	122	122	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFXN2	Q96NB2	274	289	1	322	Chain	ID=PRO_0000177035;Note=Sideroflexin-2
SFXN2	Q96NB2	274	289	265	287	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SFXN3	Q9BWM7	54	110	1	321	Chain	ID=PRO_0000177037;Note=Sideroflexin-3
SH2B3	Q9UQQ2	244	278	1	575	Chain	ID=PRO_0000084454;Note=SH2B adapter protein 3
SH2B3	Q9UQQ2	244	278	194	307	Domain	Note=PH
SH2B3	Q9UQQ2	244	278	208	575	Natural variant	ID=VAR_080828;Note=Found in a patient with isolated erythrocytosis%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20843259;Dbxref=PMID:20843259
SH2B3	Q9UQQ2	244	278	262	262	Natural variant	ID=VAR_024168;Note=Associated with susceptibility to CELIAC13 and IDDM. W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17554260,ECO:0000269|PubMed:18311140;Dbxref=dbSNP:rs3184504,PMID:17554260,PMID:18311140
SH3GL2	Q99962	15	38	1	352	Chain	ID=PRO_0000146747;Note=Endophilin-A1
SH3GL2	Q99962	62	110	1	352	Chain	ID=PRO_0000146747;Note=Endophilin-A1
SH3GL2	Q99962	15	38	18	249	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GL2	Q99962	62	110	18	249	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GL2	Q99962	15	38	1	125	Region	Note=Binds and tubulates liposomes;Ontology_term=ECO:0000250;evidence=ECO:0000250
SH3GL2	Q99962	62	110	1	125	Region	Note=Binds and tubulates liposomes;Ontology_term=ECO:0000250;evidence=ECO:0000250
SH3GL2	Q99962	15	38	1	21	Region	Note=Membrane-binding amphipathic helix;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16763557;Dbxref=PMID:16763557
SH3GL2	Q99962	62	110	60	87	Region	Note=Required for dimerization upon membrane association;Ontology_term=ECO:0000250;evidence=ECO:0000250
SH3GL2	Q99962	62	110	63	63	Mutagenesis	Note=Reduced tubulation of liposomes%2C 3-fold increase in tubule diameter%2C no effect on liposome binding%3B when associated with S-66 or with S-66 and Q-70. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16763557;Dbxref=PMID:16763557
SH3GL2	Q99962	62	110	66	66	Mutagenesis	Note=Loss of tubulation of liposomes%2C no effect on liposome binding. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16763557;Dbxref=PMID:16763557
SH3GL2	Q99962	62	110	66	66	Mutagenesis	Note=Reduced tubulation of liposomes%2C 3-fold increase in tubule diameter%2C no effect on liposome binding%3B when associated with S-63 or with S-63 and Q-70. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16763557;Dbxref=PMID:16763557
SH3GL2	Q99962	62	110	66	66	Mutagenesis	Note=Vesiculation of liposomes%2C no effect on liposome binding%2C indol ring located in hydrophobic core of the membrane. A->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16763557;Dbxref=PMID:16763557
SH3GL2	Q99962	62	110	70	70	Mutagenesis	Note=Reduced tubulation of liposomes%2C 3-fold increase in tubule diameter%2C no effect on liposome binding%3B when associated with S-63 and S-66. M->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16763557;Dbxref=PMID:16763557
SH3GL2	Q99962	15	38	12	21	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D4C
SH3GL2	Q99962	15	38	24	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D4C
SH3GL2	Q99962	62	110	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D4C
SH3GL2	Q99962	62	110	65	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X03
SH3GL2	Q99962	62	110	89	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D4C
SH3GL2	Q99962	62	110	106	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D4C
SH3GL2	Q99962	62	110	110	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D4C
SHISA9	B4DS77	323	339	24	424	Chain	ID=PRO_0000392536;Note=Protein shisa-9
SHISA9	B4DS77	323	339	171	424	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SHISA9	B4DS77	323	339	222	424	Alternative sequence	ID=VSP_038819;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACAT1	P24752	79	111	34	427	Chain	ID=PRO_0000034085;Note=Acetyl-CoA acetyltransferase%2C mitochondrial
ACAT1	P24752	145	193	34	427	Chain	ID=PRO_0000034085;Note=Acetyl-CoA acetyltransferase%2C mitochondrial
ACAT1	P24752	243	275	34	427	Chain	ID=PRO_0000034085;Note=Acetyl-CoA acetyltransferase%2C mitochondrial
ACAT1	P24752	243	275	258	260	Region	Note=Coenzyme A binding
ACAT1	P24752	243	275	263	263	Binding site	Note=Coenzyme A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17371050;Dbxref=PMID:17371050
ACAT1	P24752	145	193	174	174	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACAT1	P24752	145	193	174	174	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	145	193	181	181	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACAT1	P24752	145	193	181	181	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	145	193	190	190	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	145	193	190	190	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	243	275	243	243	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	243	275	251	251	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACAT1	P24752	243	275	257	257	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	243	275	263	263	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ACAT1	P24752	243	275	263	263	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	243	275	266	266	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	243	275	268	268	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	243	275	273	273	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8QZT1
ACAT1	P24752	145	193	146	162	Alternative sequence	ID=VSP_056844;Note=In isoform 2. DVMVAGGMESMSNVPYV->IKQETGSLAKICCHVRR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAT1	P24752	145	193	163	427	Alternative sequence	ID=VSP_056845;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAT1	P24752	243	275	163	427	Alternative sequence	ID=VSP_056845;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACAT1	P24752	79	111	85	85	Natural variant	ID=VAR_007497;Note=In 3KTD. Missing
ACAT1	P24752	79	111	93	93	Natural variant	ID=VAR_007498;Note=In 3KTD%3B 10%25 activity. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9744475;Dbxref=dbSNP:rs120074145,PMID:9744475
ACAT1	P24752	145	193	152	152	Natural variant	ID=VAR_007499;Note=In 3KTD. G->A;Dbxref=dbSNP:rs762991875
ACAT1	P24752	145	193	158	158	Natural variant	ID=VAR_007500;Note=In 3KTD%3B no activity. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7728148;Dbxref=dbSNP:rs148639841,PMID:7728148
ACAT1	P24752	145	193	183	183	Natural variant	ID=VAR_007501;Note=In 3KTD%3B no activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1346617;Dbxref=dbSNP:rs120074141,PMID:1346617
ACAT1	P24752	79	111	64	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	79	111	83	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	79	111	88	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	79	111	103	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	146	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	165	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	173	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	178	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	187	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	145	193	193	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	243	275	248	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	243	275	255	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	243	275	261	263	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	243	275	264	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
ACAT1	P24752	243	275	273	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IB8
SIGLEC7	Q9Y286	144	237	19	467	Chain	ID=PRO_0000014947;Note=Sialic acid-binding Ig-like lectin 7
SIGLEC7	Q9Y286	144	237	19	353	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC7	Q9Y286	144	237	150	233	Domain	Note=Ig-like C2-type 1
SIGLEC7	Q9Y286	144	237	165	165	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC7	Q9Y286	144	237	229	229	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC7	Q9Y286	144	237	235	235	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC7	Q9Y286	144	237	168	217	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC7	Q9Y286	144	237	145	238	Alternative sequence	ID=VSP_002555;Note=In isoform 2. ALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSY->D;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10499918,ECO:0000303|PubMed:10764831,ECO:0000303|Ref.3;Dbxref=PMID:10499918,PMID:10764831
SIGLEC7	Q9Y286	144	237	145	145	Alternative sequence	ID=VSP_002556;Note=In isoform 3. A->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10499918;Dbxref=PMID:10499918
SIGLEC7	Q9Y286	144	237	145	145	Alternative sequence	ID=VSP_002557;Note=In isoform 4. A->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10499918;Dbxref=PMID:10499918
SIGLEC7	Q9Y286	144	237	146	467	Alternative sequence	ID=VSP_002558;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10499918;Dbxref=PMID:10499918
SIGLEC7	Q9Y286	144	237	215	215	Natural variant	ID=VAR_035523;Note=In a colorectal cancer sample%3B somatic mutation. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
SIGLEC7	Q9Y286	144	237	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NKO
SIGLEC8	Q9NYZ4	151	244	17	499	Chain	ID=PRO_0000014948;Note=Sialic acid-binding Ig-like lectin 8
SIGLEC8	Q9NYZ4	151	244	17	363	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC8	Q9NYZ4	151	244	157	240	Domain	Note=Ig-like C2-type 1
SIGLEC8	Q9NYZ4	151	244	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIGLEC8	Q9NYZ4	151	244	42	181	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC8	Q9NYZ4	151	244	175	224	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIGLEC8	Q9NYZ4	151	244	152	245	Alternative sequence	ID=VSP_002559;Note=In isoform 2. ALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSY->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
SIGLEC8	Q9NYZ4	151	244	170	170	Natural variant	ID=VAR_021487;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs10409962,PMID:15489334
SIGLEC8	Q9NYZ4	151	244	146	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N7A
SIGLEC8	Q9NYZ4	151	244	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N7A
SLC9B2	Q86UD5	332	382	1	537	Chain	ID=PRO_0000331270;Note=Sodium/hydrogen exchanger 9B2
SLC9B2	Q86UD5	90	147	1	537	Chain	ID=PRO_0000331270;Note=Sodium/hydrogen exchanger 9B2
SLC9B2	Q86UD5	332	382	1	537	Chain	ID=PRO_0000331270;Note=Sodium/hydrogen exchanger 9B2
SLC9B2	Q86UD5	90	147	1	537	Chain	ID=PRO_0000331270;Note=Sodium/hydrogen exchanger 9B2
SLC9B2	Q86UD5	90	147	87	107	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	90	147	87	107	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	90	147	115	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	90	147	115	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	90	147	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	90	147	136	156	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	332	382	341	361	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	332	382	341	361	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	332	382	363	383	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	332	382	363	383	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B2	Q86UD5	332	382	357	357	Natural variant	ID=VAR_042753;Note=F->C;Dbxref=dbSNP:rs2276976
SLC9B2	Q86UD5	332	382	357	357	Natural variant	ID=VAR_042753;Note=F->C;Dbxref=dbSNP:rs2276976
SLC9A5	Q14940	62	163	1	896	Chain	ID=PRO_0000052360;Note=Sodium/hydrogen exchanger 5
SLC9A5	Q14940	62	163	46	66	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A5	Q14940	62	163	74	94	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A5	Q14940	62	163	104	124	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A5	Q14940	62	163	135	155	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SNX14	Q9Y5W7	852	884	1	946	Chain	ID=PRO_0000213861;Note=Sorting nexin-14
SNX14	Q9Y5W7	797	852	1	946	Chain	ID=PRO_0000213861;Note=Sorting nexin-14
SNX14	Q9Y5W7	603	631	1	946	Chain	ID=PRO_0000213861;Note=Sorting nexin-14
SNX14	Q9Y5W7	304	331	1	946	Chain	ID=PRO_0000213861;Note=Sorting nexin-14
SNX14	Q9Y5W7	304	331	130	304	Domain	Note=PXA;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147,ECO:0000255|PROSITE-ProRule:PRU00553
SNX14	Q9Y5W7	603	631	570	690	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX14	Q9Y5W7	304	331	317	317	Sequence conflict	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX14	Q9Y5W7	304	331	322	322	Sequence conflict	Note=F->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX14	Q9Y5W7	852	884	882	882	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX14	Q9Y5W7	603	631	609	615	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BGJ
SNX14	Q9Y5W7	603	631	617	631	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BGJ
SUPT20H	Q8NEM7	624	664	1	779	Chain	ID=PRO_0000187039;Note=Transcription factor SPT20 homolog
SUPT20H	Q8NEM7	477	530	1	779	Chain	ID=PRO_0000187039;Note=Transcription factor SPT20 homolog
SUPT20H	Q8NEM7	307	331	1	779	Chain	ID=PRO_0000187039;Note=Transcription factor SPT20 homolog
SUPT20H	Q8NEM7	288	307	1	779	Chain	ID=PRO_0000187039;Note=Transcription factor SPT20 homolog
SUPT20H	Q8NEM7	1	13	1	779	Chain	ID=PRO_0000187039;Note=Transcription factor SPT20 homolog
SUPT20H	Q8NEM7	624	664	636	754	Compositional bias	Note=Gln-rich
SUPT20H	Q8NEM7	288	307	296	296	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TT00
SUPT20H	Q8NEM7	477	530	494	494	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SUPT20H	Q8NEM7	477	530	519	519	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
SUPT20H	Q8NEM7	477	530	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TT00
SEMA4F	O95754	119	152	35	770	Chain	ID=PRO_0000032330;Note=Semaphorin-4F
SEMA4F	O95754	119	152	35	659	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4F	O95754	119	152	42	510	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4F	O95754	119	152	133	133	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SEMA4F	O95754	119	152	112	122	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4F	O95754	119	152	140	149	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
SEMA4F	O95754	119	152	120	274	Alternative sequence	ID=VSP_006043;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10051670,ECO:0000303|PubMed:15489334;Dbxref=PMID:10051670,PMID:15489334
SET	Q01105	177	234	2	290	Chain	ID=PRO_0000185662;Note=Protein SET
SET	Q01105	177	234	79	225	Region	Note=Earmuff domain
SET	Q01105	177	234	233	290	Natural variant	ID=VAR_078653;Note=Probable disease-associated mutation found in a patient with congenital microcephaly and moderate intellecutal disability. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
SET	Q01105	177	234	203	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E50
SET	Q01105	177	234	215	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E50
SET	Q01105	177	234	224	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E50
SET	Q01105	177	234	230	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E50
SF3B3	Q15393	411	443	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	622	670	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	670	711	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	942	984	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	984	1055	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	1055	1088	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	1088	1136	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	1136	1171	1	1217	Chain	ID=PRO_0000218639;Note=Splicing factor 3B subunit 3
SF3B3	Q15393	984	1055	1028	1049	Region	Note=Interaction with SF3B1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27720643;Dbxref=PMID:27720643
SF3B3	Q15393	1088	1136	1100	1123	Region	Note=Interaction with SF3B5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27720643;Dbxref=PMID:27720643
SF3B3	Q15393	411	443	429	429	Site	Note=Interaction with SF3B5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27720643;Dbxref=PMID:27720643
SF3B3	Q15393	984	1055	988	988	Site	Note=Interaction with SF3B1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27720643;Dbxref=PMID:27720643
SF3B3	Q15393	1136	1171	1171	1171	Site	Note=Interaction with SF3B1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27720643;Dbxref=PMID:27720643
SF3B3	Q15393	411	443	1	818	Alternative sequence	ID=VSP_022977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	622	670	1	818	Alternative sequence	ID=VSP_022977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	670	711	1	818	Alternative sequence	ID=VSP_022977;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	411	443	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	622	670	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	670	711	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	942	984	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	984	1055	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	1055	1088	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	1088	1136	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	1136	1171	276	1217	Alternative sequence	ID=VSP_022979;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SF3B3	Q15393	411	443	406	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	411	443	416	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	411	443	422	427	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	411	443	430	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	411	443	434	442	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	622	670	621	623	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	622	670	626	632	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	622	670	637	644	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	622	670	663	682	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	670	711	663	682	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	670	711	686	690	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	670	711	700	706	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	670	711	709	727	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	942	984	939	947	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	942	984	949	955	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	942	984	958	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	942	984	966	971	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	942	984	974	976	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	942	984	978	983	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	990	994	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	997	1007	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	1009	1015	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	1016	1019	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	1020	1029	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	1033	1038	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	1040	1048	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	984	1055	1051	1057	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1055	1088	1051	1057	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1055	1088	1085	1096	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1088	1136	1085	1096	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1088	1136	1101	1110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1088	1136	1115	1121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1088	1136	1126	1129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1088	1136	1135	1151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1136	1171	1135	1151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1136	1171	1160	1164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1136	1171	1166	1168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B3	Q15393	1136	1171	1171	1175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SGSM2	O43147	594	655	1	1006	Chain	ID=PRO_0000284662;Note=Small G protein signaling modulator 2
SGSM2	O43147	594	655	566	939	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
SGSM2	O43147	594	655	570	1006	Alternative sequence	ID=VSP_024598;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SH3BGR	P55822	140	167	1	239	Chain	ID=PRO_0000220743;Note=SH3 domain-binding glutamic acid-rich protein
SH3BGR	P55822	167	198	1	239	Chain	ID=PRO_0000220743;Note=SH3 domain-binding glutamic acid-rich protein
SH3BGR	P55822	198	208	1	239	Chain	ID=PRO_0000220743;Note=SH3 domain-binding glutamic acid-rich protein
SH3BGR	P55822	167	198	170	239	Compositional bias	Note=Glu-rich (acidic)
SH3BGR	P55822	198	208	170	239	Compositional bias	Note=Glu-rich (acidic)
SH3BGR	P55822	167	198	188	188	Natural variant	ID=VAR_028233;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs9974333,PMID:15489334
SH3RF2	Q8TEC5	248	353	1	729	Chain	ID=PRO_0000269512;Note=E3 ubiquitin-protein ligase SH3RF2
SH3RF2	Q8TEC5	384	440	1	729	Chain	ID=PRO_0000269512;Note=E3 ubiquitin-protein ligase SH3RF2
SH3RF2	Q8TEC5	248	353	1	729	Chain	ID=PRO_0000269512;Note=E3 ubiquitin-protein ligase SH3RF2
SH3RF2	Q8TEC5	384	440	1	729	Chain	ID=PRO_0000269512;Note=E3 ubiquitin-protein ligase SH3RF2
SH3RF2	Q8TEC5	248	353	187	252	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF2	Q8TEC5	248	353	187	252	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF2	Q8TEC5	384	440	380	441	Domain	Note=SH3 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF2	Q8TEC5	384	440	380	441	Domain	Note=SH3 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SH3RF2	Q8TEC5	384	440	370	459	Region	Note=Interaction with PAK4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24130170;Dbxref=PMID:24130170
SH3RF2	Q8TEC5	384	440	370	459	Region	Note=Interaction with PAK4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24130170;Dbxref=PMID:24130170
SH3RF2	Q8TEC5	248	353	1	543	Alternative sequence	ID=VSP_040662;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19945436;Dbxref=PMID:19945436
SH3RF2	Q8TEC5	384	440	1	543	Alternative sequence	ID=VSP_040662;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19945436;Dbxref=PMID:19945436
SH3RF2	Q8TEC5	248	353	1	543	Alternative sequence	ID=VSP_040662;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19945436;Dbxref=PMID:19945436
SH3RF2	Q8TEC5	384	440	1	543	Alternative sequence	ID=VSP_040662;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19945436;Dbxref=PMID:19945436
SH3RF2	Q8TEC5	248	353	1	508	Alternative sequence	ID=VSP_022058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SH3RF2	Q8TEC5	384	440	1	508	Alternative sequence	ID=VSP_022058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SH3RF2	Q8TEC5	248	353	1	508	Alternative sequence	ID=VSP_022058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SH3RF2	Q8TEC5	384	440	1	508	Alternative sequence	ID=VSP_022058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SH3RF2	Q8TEC5	248	353	267	267	Natural variant	ID=VAR_029788;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs758037,PMID:14702039,PMID:15489334
SH3RF2	Q8TEC5	248	353	267	267	Natural variant	ID=VAR_029788;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs758037,PMID:14702039,PMID:15489334
SGK2	Q9HBY8	108	136	1	427	Chain	ID=PRO_0000086646;Note=Serine/threonine-protein kinase Sgk2
SGK2	Q9HBY8	230	259	1	427	Chain	ID=PRO_0000086646;Note=Serine/threonine-protein kinase Sgk2
SGK2	Q9HBY8	291	343	1	427	Chain	ID=PRO_0000086646;Note=Serine/threonine-protein kinase Sgk2
SGK2	Q9HBY8	343	373	1	427	Chain	ID=PRO_0000086646;Note=Serine/threonine-protein kinase Sgk2
SGK2	Q9HBY8	108	136	95	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK2	Q9HBY8	230	259	95	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK2	Q9HBY8	291	343	95	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK2	Q9HBY8	343	373	95	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK2	Q9HBY8	343	373	353	427	Domain	Note=AGC-kinase C-terminal
SGK2	Q9HBY8	108	136	101	109	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK2	Q9HBY8	108	136	128	138	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250
SGK2	Q9HBY8	108	136	124	124	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK2	Q9HBY8	230	259	253	253	Modified residue	Note=Phosphothreonine%3B by PDPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548550;Dbxref=PMID:10548550
SGK2	Q9HBY8	230	259	259	259	Natural variant	ID=VAR_041074;Note=In a lung adenocarcinoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
SGK2	Q9HBY8	343	373	349	349	Natural variant	ID=VAR_041075;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35793869,PMID:17344846
SGK2	Q9HBY8	291	343	337	337	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIRT5	Q9NXA8	188	205	37	310	Chain	ID=PRO_0000110266;Note=NAD-dependent protein deacylase sirtuin-5%2C mitochondrial
SIRT5	Q9NXA8	188	205	41	309	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03160
SIRT5	Q9NXA8	188	205	189	206	Alternative sequence	ID=VSP_042292;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SIRT5	Q9NXA8	188	205	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HDA
SIRT5	Q9NXA8	188	205	201	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EQS
SKAP1	Q86WV1	275	292	1	359	Chain	ID=PRO_0000270173;Note=Src kinase-associated phosphoprotein 1
SKAP1	Q86WV1	119	147	1	359	Chain	ID=PRO_0000270173;Note=Src kinase-associated phosphoprotein 1
SKAP1	Q86WV1	93	119	1	359	Chain	ID=PRO_0000270173;Note=Src kinase-associated phosphoprotein 1
SKAP1	Q86WV1	275	292	1	359	Chain	ID=PRO_0000270173;Note=Src kinase-associated phosphoprotein 1
SKAP1	Q86WV1	119	147	1	359	Chain	ID=PRO_0000270173;Note=Src kinase-associated phosphoprotein 1
SKAP1	Q86WV1	93	119	1	359	Chain	ID=PRO_0000270173;Note=Src kinase-associated phosphoprotein 1
SKAP1	Q86WV1	119	147	107	210	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SKAP1	Q86WV1	93	119	107	210	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SKAP1	Q86WV1	119	147	107	210	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SKAP1	Q86WV1	93	119	107	210	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
SKAP1	Q86WV1	275	292	290	295	Region	Note=Interaction with FYB1
SKAP1	Q86WV1	275	292	290	295	Region	Note=Interaction with FYB1
SKAP1	Q86WV1	119	147	142	142	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UUV5
SKAP1	Q86WV1	119	147	142	142	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UUV5
SKAP1	Q86WV1	119	147	108	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	93	119	108	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	108	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	93	119	108	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	121	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	121	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	126	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	126	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	139	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SKAP1	Q86WV1	119	147	139	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U5D
SIRT7	Q9NRC8	160	193	1	400	Chain	ID=PRO_0000110271;Note=NAD-dependent protein deacetylase sirtuin-7
SIRT7	Q9NRC8	77	112	1	400	Chain	ID=PRO_0000110271;Note=NAD-dependent protein deacetylase sirtuin-7
SIRT7	Q9NRC8	31	77	1	400	Chain	ID=PRO_0000110271;Note=NAD-dependent protein deacetylase sirtuin-7
SIRT7	Q9NRC8	160	193	90	331	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236
SIRT7	Q9NRC8	77	112	90	331	Domain	Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236
SIRT7	Q9NRC8	77	112	107	126	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIRT7	Q9NRC8	160	193	167	170	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIRT7	Q9NRC8	31	77	8	74	Compositional bias	Note=Arg-rich
SIRT7	Q9NRC8	160	193	187	187	Active site	Note=Proton acceptor
SIRT7	Q9NRC8	160	193	162	183	Alternative sequence	ID=VSP_008736;Note=In isoform 2. QHVVSQNCDGLHLRSGLPRTAI->RALGGWYTCQGPGRAPWCPVGN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SIRT7	Q9NRC8	160	193	184	400	Alternative sequence	ID=VSP_008737;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SIRT7	Q9NRC8	77	112	111	111	Mutagenesis	Note=Abolishes activation of pre-rRNA synthesis. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16618798,ECO:0000269|PubMed:22586326;Dbxref=PMID:16618798,PMID:22586326
SIRT7	Q9NRC8	160	193	187	187	Mutagenesis	Note=Abolishes deacetylase activity and activation of pre-rRNA synthesis. H->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16618798,ECO:0000269|PubMed:22722849;Dbxref=PMID:16618798,PMID:22722849
SIRT7	Q9NRC8	31	77	71	71	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIRT7	Q9NRC8	31	77	8	37	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQZ
SIRT7	Q9NRC8	31	77	40	42	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQZ
SIRT7	Q9NRC8	31	77	45	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQZ
SIRT7	Q9NRC8	31	77	55	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IQZ
SKOR1	P84550	838	862	1	965	Chain	ID=PRO_0000129390;Note=SKI family transcriptional corepressor 1
SKOR1	P84550	838	862	858	922	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B1	Q4ZJI4	70	127	1	515	Chain	ID=PRO_0000314007;Note=Sodium/hydrogen exchanger 9B1
SLC9B1	Q4ZJI4	70	127	66	86	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B1	Q4ZJI4	70	127	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B1	Q4ZJI4	70	127	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9B1	Q4ZJI4	70	127	1	232	Alternative sequence	ID=VSP_030175;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC9B1	Q4ZJI4	70	127	71	73	Alternative sequence	ID=VSP_030176;Note=In isoform 4. GVI->VLF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC9B1	Q4ZJI4	70	127	74	515	Alternative sequence	ID=VSP_030177;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC9A3	P48764	713	750	1	834	Chain	ID=PRO_0000052356;Note=Sodium/hydrogen exchanger 3
SLC9A3	P48764	713	750	457	834	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF1	Q13291	233	263	21	335	Chain	ID=PRO_0000014959;Note=Signaling lymphocytic activation molecule
SLAMF1	Q13291	233	263	21	237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF1	Q13291	233	263	238	258	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF1	Q13291	233	263	259	335	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF1	Q13291	233	263	234	263	Alternative sequence	ID=VSP_002567;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7617038;Dbxref=PMID:7617038
SLC9A8	Q9Y2E8	69	96	1	581	Chain	ID=PRO_0000052365;Note=Sodium/hydrogen exchanger 8
SLC9A8	Q9Y2E8	116	144	1	581	Chain	ID=PRO_0000052365;Note=Sodium/hydrogen exchanger 8
SLC9A8	Q9Y2E8	319	358	1	581	Chain	ID=PRO_0000052365;Note=Sodium/hydrogen exchanger 8
SLC9A8	Q9Y2E8	497	546	1	581	Chain	ID=PRO_0000052365;Note=Sodium/hydrogen exchanger 8
SLC9A8	Q9Y2E8	69	96	60	80	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A8	Q9Y2E8	69	96	84	104	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A8	Q9Y2E8	116	144	123	143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A8	Q9Y2E8	319	358	311	331	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A8	Q9Y2E8	319	358	354	374	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC9A8	Q9Y2E8	497	546	510	510	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R4D1
SNX4	O95219	285	314	1	450	Chain	ID=PRO_0000213842;Note=Sorting nexin-4
SNX16	P57768	125	154	1	344	Chain	ID=PRO_0000213863;Note=Sorting nexin-16
SNX16	P57768	125	154	1	344	Chain	ID=PRO_0000213863;Note=Sorting nexin-16
SNX16	P57768	125	154	105	218	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX16	P57768	125	154	105	218	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX16	P57768	125	154	144	144	Binding site	Note=Phosphatidylinositol 3-phosphate;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX16	P57768	125	154	144	144	Binding site	Note=Phosphatidylinositol 3-phosphate;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNX16	P57768	125	154	146	146	Binding site	Note=Phosphatidylinositol 3-phosphate%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
SNX16	P57768	125	154	146	146	Binding site	Note=Phosphatidylinositol 3-phosphate%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
SNX16	P57768	125	154	126	154	Alternative sequence	ID=VSP_042944;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNX16	P57768	125	154	126	154	Alternative sequence	ID=VSP_042944;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNX16	P57768	125	154	144	144	Mutagenesis	Note=Abolishes binding to membranes enriched in phosphatidylinositol 3-phosphate. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15951806;Dbxref=PMID:15951806
SNX16	P57768	125	154	144	144	Mutagenesis	Note=Abolishes binding to membranes enriched in phosphatidylinositol 3-phosphate. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15951806;Dbxref=PMID:15951806
SNX16	P57768	125	154	145	145	Mutagenesis	Note=Abolishes binding to phosphatidylinositol 3-phosphate. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12813048;Dbxref=PMID:12813048
SNX16	P57768	125	154	145	145	Mutagenesis	Note=Abolishes binding to phosphatidylinositol 3-phosphate. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12813048;Dbxref=PMID:12813048
SNX16	P57768	125	154	108	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW0
SNX16	P57768	125	154	108	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW0
SNX16	P57768	125	154	138	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW0
SNX16	P57768	125	154	138	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW0
SNX16	P57768	125	154	145	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW0
SNX16	P57768	125	154	145	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW0
SORL1	Q92673	176	230	82	2214	Chain	ID=PRO_0000033165;Note=Sortilin-related receptor
SORL1	Q92673	313	347	82	2214	Chain	ID=PRO_0000033165;Note=Sortilin-related receptor
SORL1	Q92673	684	726	82	2214	Chain	ID=PRO_0000033165;Note=Sortilin-related receptor
SORL1	Q92673	1074	1112	82	2214	Chain	ID=PRO_0000033165;Note=Sortilin-related receptor
SORL1	Q92673	1506	1550	82	2214	Chain	ID=PRO_0000033165;Note=Sortilin-related receptor
SORL1	Q92673	176	230	82	2137	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORL1	Q92673	313	347	82	2137	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORL1	Q92673	684	726	82	2137	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORL1	Q92673	1074	1112	82	2137	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORL1	Q92673	1506	1550	82	2137	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SORL1	Q92673	1074	1112	1076	1114	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1506	1550	1469	1508	Domain	Note=LDL-receptor class A 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1506	1550	1512	1551	Domain	Note=LDL-receptor class A 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1074	1112	1078	1090	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1074	1112	1085	1103	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1074	1112	1097	1112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1506	1550	1491	1506	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1506	1550	1514	1527	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1506	1550	1521	1540	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1506	1550	1534	1549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
SORL1	Q92673	1074	1112	1074	1074	Natural variant	ID=VAR_034508;Note=Q->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8940146,ECO:0000269|PubMed:9157966,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1699107,PMID:15489334,PMID:8940146,PMID:9157966
SORL1	Q92673	176	230	177	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	176	230	198	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	176	230	207	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	176	230	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	176	230	230	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	313	347	306	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	313	347	318	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSY
SORL1	Q92673	313	347	323	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	313	347	333	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSZ
SORL1	Q92673	684	726	682	684	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	684	726	688	690	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	684	726	694	696	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	684	726	699	701	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	684	726	703	705	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SORL1	Q92673	684	726	722	724	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WSX
SOS2	Q07890	986	1025	1	1332	Chain	ID=PRO_0000068896;Note=Son of sevenless homolog 2
SOS2	Q07890	323	356	1	1332	Chain	ID=PRO_0000068896;Note=Son of sevenless homolog 2
SOS2	Q07890	286	323	1	1332	Chain	ID=PRO_0000068896;Note=Son of sevenless homolog 2
SOS2	Q07890	238	286	1	1332	Chain	ID=PRO_0000068896;Note=Son of sevenless homolog 2
SOS2	Q07890	170	238	1	1332	Chain	ID=PRO_0000068896;Note=Son of sevenless homolog 2
SOS2	Q07890	115	170	1	1332	Chain	ID=PRO_0000068896;Note=Son of sevenless homolog 2
SOS2	Q07890	323	356	198	388	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS2	Q07890	286	323	198	388	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS2	Q07890	238	286	198	388	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS2	Q07890	170	238	198	388	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
SOS2	Q07890	986	1025	778	1017	Domain	Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168
SOS2	Q07890	323	356	324	356	Alternative sequence	ID=VSP_054492;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SOS2	Q07890	238	286	267	267	Natural variant	ID=VAR_075686;Note=In NS9. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25795793;Dbxref=dbSNP:rs797045167,PMID:25795793
SOS2	Q07890	286	323	310	310	Natural variant	ID=VAR_075687;Note=In NS9%3B unknown pathological significance. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25795793;Dbxref=PMID:25795793
SOS2	Q07890	323	356	334	334	Natural variant	ID=VAR_075688;Note=In NS9%3B unknown pathological significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25795793;Dbxref=dbSNP:rs373233749,PMID:25795793
SOS2	Q07890	170	238	192	192	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
SOS2	Q07890	238	286	239	240	Sequence conflict	Note=DI->VY;Ontology_term=ECO:0000305;evidence=ECO:0000305
SOS2	Q07890	986	1025	999	999	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATS2	Q86XZ4	175	234	1	545	Chain	ID=PRO_0000307697;Note=Spermatogenesis-associated serine-rich protein 2
SPATS2	Q86XZ4	175	234	1	545	Chain	ID=PRO_0000307697;Note=Spermatogenesis-associated serine-rich protein 2
SPATS2	Q86XZ4	175	234	1	545	Chain	ID=PRO_0000307697;Note=Spermatogenesis-associated serine-rich protein 2
SESN3	P58005	175	254	1	492	Chain	ID=PRO_0000221183;Note=Sestrin-3
SESN3	P58005	114	175	1	492	Chain	ID=PRO_0000221183;Note=Sestrin-3
SESN3	P58005	175	254	115	175	Alternative sequence	ID=VSP_054564;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SESN3	P58005	114	175	115	175	Alternative sequence	ID=VSP_054564;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SESN3	P58005	175	254	227	227	Natural variant	ID=VAR_051959;Note=I->T;Dbxref=dbSNP:rs11021069
SF3B1	O75533	1045	1088	1	1304	Chain	ID=PRO_0000174323;Note=Splicing factor 3B subunit 1
SF3B1	O75533	165	222	1	1304	Chain	ID=PRO_0000174323;Note=Splicing factor 3B subunit 1
SF3B1	O75533	1045	1088	1010	1048	Repeat	Note=HEAT 8
SF3B1	O75533	1045	1088	1052	1090	Repeat	Note=HEAT 9
SF3B1	O75533	165	222	190	342	Region	Note=U2AF homology region%3B mediates interaction with RBM39;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24795046;Dbxref=PMID:24795046
SF3B1	O75533	1045	1088	1049	1049	Site	Note=Interaction with RNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27720643;Dbxref=PMID:27720643
SF3B1	O75533	165	222	194	194	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
SF3B1	O75533	165	222	203	203	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
SF3B1	O75533	165	222	207	207	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
SF3B1	O75533	165	222	211	211	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SF3B1	O75533	165	222	214	214	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99NB9
SF3B1	O75533	165	222	214	214	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SF3B1	O75533	1045	1088	145	1304	Alternative sequence	ID=VSP_046183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SF3B1	O75533	165	222	145	1304	Alternative sequence	ID=VSP_046183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SF3B1	O75533	165	222	200	200	Mutagenesis	Note=Abolishes interaction with RBM39%3B when associated with A-218%3B A-232%3B A-254%3B A-293%3B A-310 and A-338. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24795046;Dbxref=PMID:24795046
SF3B1	O75533	165	222	218	218	Mutagenesis	Note=Abolishes interaction with RBM39%3B when associated with A-200%3B A-232%3B A-254%3B A-293%3B A-310 and A-338. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24795046;Dbxref=PMID:24795046
SF3B1	O75533	1045	1088	1029	1045	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B1	O75533	1045	1088	1047	1049	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B1	O75533	1045	1088	1052	1062	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B1	O75533	1045	1088	1063	1067	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SF3B1	O75533	1045	1088	1071	1088	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IFE
SH2B2	O14492	286	320	1	632	Chain	ID=PRO_0000064647;Note=SH2B adapter protein 2
SH2B2	O14492	286	320	193	306	Domain	Note=PH;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00145,ECO:0000305
SH2B2	O14492	286	320	310	310	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JID9
SGK3	Q96BR1	326	358	1	496	Chain	ID=PRO_0000086649;Note=Serine/threonine-protein kinase Sgk3
SGK3	Q96BR1	326	358	1	496	Chain	ID=PRO_0000086649;Note=Serine/threonine-protein kinase Sgk3
SGK3	Q96BR1	326	358	1	496	Chain	ID=PRO_0000086649;Note=Serine/threonine-protein kinase Sgk3
SGK3	Q96BR1	326	358	1	496	Chain	ID=PRO_0000086649;Note=Serine/threonine-protein kinase Sgk3
SGK3	Q96BR1	326	358	162	419	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK3	Q96BR1	326	358	162	419	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK3	Q96BR1	326	358	162	419	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK3	Q96BR1	326	358	162	419	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SGK3	Q96BR1	326	358	327	358	Alternative sequence	ID=VSP_041903;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SGK3	Q96BR1	326	358	327	358	Alternative sequence	ID=VSP_041903;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SGK3	Q96BR1	326	358	327	358	Alternative sequence	ID=VSP_041903;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SGK3	Q96BR1	326	358	327	358	Alternative sequence	ID=VSP_041903;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SGK3	Q96BR1	326	358	355	355	Natural variant	ID=VAR_041076;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs750700898,PMID:17344846
SGK3	Q96BR1	326	358	355	355	Natural variant	ID=VAR_041076;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs750700898,PMID:17344846
SGK3	Q96BR1	326	358	355	355	Natural variant	ID=VAR_041076;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs750700898,PMID:17344846
SGK3	Q96BR1	326	358	355	355	Natural variant	ID=VAR_041076;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs750700898,PMID:17344846
SHROOM3	Q8TF72	152	195	1	1996	Chain	ID=PRO_0000286066;Note=Protein Shroom3
SHROOM3	Q8TF72	1570	1732	1	1996	Chain	ID=PRO_0000286066;Note=Protein Shroom3
SHROOM3	Q8TF72	1783	1874	1	1996	Chain	ID=PRO_0000286066;Note=Protein Shroom3
SHROOM3	Q8TF72	1570	1732	1669	1957	Domain	Note=ASD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00638
SHROOM3	Q8TF72	1783	1874	1669	1957	Domain	Note=ASD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00638
SHROOM3	Q8TF72	152	195	126	153	Alternative sequence	ID=VSP_024966;Note=In isoform 2. SPEHLTSGPQHRKAAWSGGVKLRLKHRR->MAFYSTPEYDIQLARGLLSGMFLFATRR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SHROOM3	Q8TF72	1570	1732	312	1996	Alternative sequence	ID=VSP_024968;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SHROOM3	Q8TF72	1783	1874	312	1996	Alternative sequence	ID=VSP_024968;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SHROOM3	Q8TF72	152	195	153	153	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SH3GLB1	Q9Y371	71	114	1	365	Chain	ID=PRO_0000146753;Note=Endophilin-B1
SH3GLB1	Q9Y371	71	114	27	261	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
SH3GLB1	Q9Y371	71	114	1	100	Alternative sequence	ID=VSP_044895;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SHISA5	Q8N114	143	214	29	240	Chain	ID=PRO_0000312878;Note=Protein shisa-5
SHISA5	Q8N114	78	104	29	240	Chain	ID=PRO_0000312878;Note=Protein shisa-5
SHISA5	Q8N114	78	104	29	105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SHISA5	Q8N114	143	214	127	240	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SHISA5	Q8N114	143	214	147	153	Compositional bias	Note=Poly-Thr
SHISA5	Q8N114	143	214	158	230	Compositional bias	Note=Pro-rich
SHISA5	Q8N114	78	104	1	103	Alternative sequence	ID=VSP_029953;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12761501,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:12761501,PMID:15489334,PMID:17974005
SHISA5	Q8N114	78	104	104	104	Alternative sequence	ID=VSP_029955;Note=In isoform 3 and isoform 4. S->M;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12761501,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:12761501,PMID:15489334,PMID:17974005
SIPA1L3	O60292	1132	1177	1	1781	Chain	ID=PRO_0000056752;Note=Signal-induced proliferation-associated 1-like protein 3
SIPA1L3	O60292	1403	1476	1	1781	Chain	ID=PRO_0000056752;Note=Signal-induced proliferation-associated 1-like protein 3
SIPA1L3	O60292	1613	1661	1	1781	Chain	ID=PRO_0000056752;Note=Signal-induced proliferation-associated 1-like protein 3
SIPA1L3	O60292	1403	1476	1448	1448	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SIPA1L3	O60292	1613	1661	1619	1619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3X9J0
SIPA1L3	O60292	1613	1661	1622	1622	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3X9J0
SIPA1L3	O60292	1403	1476	1450	1450	Natural variant	ID=VAR_025477;Note=P->A;Dbxref=dbSNP:rs3745945
ST3GAL2	Q16842	253	293	1	350	Chain	ID=PRO_0000149258;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 2
ST3GAL2	Q16842	178	237	1	350	Chain	ID=PRO_0000149258;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 2
ST3GAL2	Q16842	253	293	1	350	Chain	ID=PRO_0000149258;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 2
ST3GAL2	Q16842	178	237	1	350	Chain	ID=PRO_0000149258;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 2
ST3GAL2	Q16842	253	293	28	350	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL2	Q16842	178	237	28	350	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL2	Q16842	253	293	28	350	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL2	Q16842	178	237	28	350	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL2	Q16842	178	237	180	180	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	178	237	180	180	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	253	293	276	276	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	253	293	276	276	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	253	293	280	280	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	253	293	280	280	Binding site	Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	178	237	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL2	Q16842	178	237	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST3GAL2	Q16842	253	293	152	291	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	178	237	152	291	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	253	293	152	291	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST3GAL2	Q16842	178	237	152	291	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SIDT2	Q8NBJ9	737	774	19	832	Chain	ID=PRO_0000032578;Note=SID1 transmembrane family member 2
SIDT2	Q8NBJ9	737	774	737	746	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIDT2	Q8NBJ9	737	774	747	767	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIDT2	Q8NBJ9	737	774	768	796	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIDT2	Q8NBJ9	737	774	764	767	Compositional bias	Note=Poly-Phe
ST6GALNAC6	Q969X2	235	270	1	333	Chain	ID=PRO_0000314795;Note=Alpha-N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 6
ST6GALNAC6	Q969X2	235	270	1	333	Chain	ID=PRO_0000314795;Note=Alpha-N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 6
ST6GALNAC6	Q969X2	235	270	65	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC6	Q969X2	235	270	65	333	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ST6GALNAC6	Q969X2	235	270	108	256	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST6GALNAC6	Q969X2	235	270	108	256	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ST6GALNAC6	Q969X2	235	270	249	249	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ST6GALNAC6	Q969X2	235	270	249	249	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
NANS	Q9NR45	201	290	2	359	Chain	ID=PRO_0000097750;Note=Sialic acid synthase
NANS	Q9NR45	201	290	275	275	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99J77
NANS	Q9NR45	201	290	290	290	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99J77
NANS	Q9NR45	201	290	237	237	Natural variant	ID=VAR_076576;Note=In SEMDG. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27213289;Dbxref=dbSNP:rs878852982,PMID:27213289
NANS	Q9NR45	201	290	232	232	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIK1	P57059	487	581	1	783	Chain	ID=PRO_0000086659;Note=Serine/threonine-protein kinase SIK1
SIK1	P57059	324	373	1	783	Chain	ID=PRO_0000086659;Note=Serine/threonine-protein kinase SIK1
SIK1	P57059	324	373	303	343	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
SIK1	P57059	487	581	575	575	Modified residue	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:Q60670,ECO:0000305
SIK1	P57059	487	581	489	490	Sequence conflict	Note=IV->KF;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIMC1	Q8NDZ2	611	661	1	872	Chain	ID=PRO_0000250581;Note=SUMO-interacting motif-containing protein 1
SIMC1	Q8NDZ2	662	704	1	872	Chain	ID=PRO_0000250581;Note=SUMO-interacting motif-containing protein 1
SIMC1	Q8NDZ2	611	661	416	872	Alternative sequence	ID=VSP_020675;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SIMC1	Q8NDZ2	662	704	416	872	Alternative sequence	ID=VSP_020675;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SIMC1	Q8NDZ2	611	661	636	636	Natural variant	ID=VAR_059603;Note=S->F;Dbxref=dbSNP:rs2001605
SIMC1	Q8NDZ2	662	704	693	693	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIRPB2	Q5JXA9	150	264	33	342	Chain	ID=PRO_0000338629;Note=Signal-regulatory protein beta-2
SIRPB2	Q5JXA9	150	264	33	287	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPB2	Q5JXA9	150	264	157	258	Domain	Note=Ig-like V-type 2
SIRPB2	Q5JXA9	150	264	179	179	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPB2	Q5JXA9	150	264	231	231	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SIRPB2	Q5JXA9	150	264	180	242	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SIRPB2	Q5JXA9	150	264	53	150	Alternative sequence	ID=VSP_034065;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:14702039
SIRPB2	Q5JXA9	150	264	153	153	Natural variant	ID=VAR_043814;Note=G->E;Dbxref=dbSNP:rs6033876
SIRPB2	Q5JXA9	150	264	215	215	Natural variant	ID=VAR_043815;Note=E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.1;Dbxref=dbSNP:rs6042507,PMID:14702039
SIN3A	Q96ST3	1065	1096	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	1007	1065	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	63	122	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	1065	1096	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	1007	1065	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	63	122	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	1065	1096	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	1007	1065	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	63	122	1	1273	Chain	ID=PRO_0000121537;Note=Paired amphipathic helix protein Sin3a
SIN3A	Q96ST3	63	122	119	189	Domain	Note=PAH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00810
SIN3A	Q96ST3	63	122	119	189	Domain	Note=PAH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00810
SIN3A	Q96ST3	63	122	119	189	Domain	Note=PAH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00810
SIN3A	Q96ST3	63	122	119	196	Region	Note=Interaction with HCFC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12670868;Dbxref=PMID:12670868
SIN3A	Q96ST3	63	122	119	196	Region	Note=Interaction with HCFC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12670868;Dbxref=PMID:12670868
SIN3A	Q96ST3	63	122	119	196	Region	Note=Interaction with HCFC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12670868;Dbxref=PMID:12670868
SIN3A	Q96ST3	1065	1096	1089	1089	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SIN3A	Q96ST3	1065	1096	1089	1089	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SIN3A	Q96ST3	1065	1096	1089	1089	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SIN3A	Q96ST3	63	122	122	122	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SIN3A	Q96ST3	63	122	122	122	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SIN3A	Q96ST3	63	122	122	122	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SIN3A	Q96ST3	1007	1065	1009	1009	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIN3A	Q96ST3	1007	1065	1009	1009	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIN3A	Q96ST3	1007	1065	1009	1009	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SIN3B	O75182	283	313	1	1162	Chain	ID=PRO_0000121539;Note=Paired amphipathic helix protein Sin3b
SIN3B	O75182	422	454	1	1162	Chain	ID=PRO_0000121539;Note=Paired amphipathic helix protein Sin3b
SIN3B	O75182	283	313	292	369	Domain	Note=PAH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00810
SIN3B	O75182	283	313	1	308	Region	Note=Interaction with CRY1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIN3B	O75182	283	313	284	540	Region	Note=Interaction with NCOR1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62141
SIN3B	O75182	422	454	284	540	Region	Note=Interaction with NCOR1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62141
SIN3B	O75182	422	454	392	591	Region	Note=Interaction with SUDS3 and HDAC1;Ontology_term=ECO:0000250;evidence=ECO:0000250
SIN3B	O75182	422	454	354	1162	Alternative sequence	ID=VSP_014185;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SIN3B	O75182	422	454	423	454	Alternative sequence	ID=VSP_014186;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
SLAMF6	Q96DU3	16	127	1	21	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
SLAMF6	Q96DU3	215	252	22	332	Chain	ID=PRO_0000014961;Note=SLAM family member 6
SLAMF6	Q96DU3	16	127	22	332	Chain	ID=PRO_0000014961;Note=SLAM family member 6
SLAMF6	Q96DU3	215	252	22	226	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF6	Q96DU3	16	127	22	226	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF6	Q96DU3	215	252	227	247	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF6	Q96DU3	215	252	248	331	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF6	Q96DU3	16	127	35	120	Domain	Note=Ig-like V-type
SLAMF6	Q96DU3	16	127	58	58	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF6	Q96DU3	16	127	87	87	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF6	Q96DU3	16	127	18	128	Alternative sequence	ID=VSP_043230;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLAMF6	Q96DU3	16	127	108	108	Mutagenesis	Note=Inhibits dimerization. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17045824;Dbxref=PMID:17045824
SLAMF6	Q96DU3	16	127	110	110	Mutagenesis	Note=Inhibits dimerization. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17045824;Dbxref=PMID:17045824
SLAMF6	Q96DU3	16	127	112	112	Mutagenesis	Note=Inhibits dimerization. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17045824;Dbxref=PMID:17045824
SLAMF6	Q96DU3	16	127	28	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	38	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	52	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	60	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	69	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	74	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	80	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	94	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	101	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	105	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF6	Q96DU3	16	127	117	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IF7
SLAMF8	Q9P0V8	122	224	23	285	Chain	ID=PRO_0000014965;Note=SLAM family member 8
SLAMF8	Q9P0V8	122	224	23	233	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF8	Q9P0V8	122	224	128	215	Domain	Note=Ig-like C2-type
SLAMF8	Q9P0V8	122	224	152	201	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SLAMF8	Q9P0V8	122	224	14	122	Alternative sequence	ID=VSP_013896;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLAMF8	Q9P0V8	122	224	129	129	Natural variant	ID=VAR_049942;Note=V->M;Dbxref=dbSNP:rs3795331
SLAMF9	Q96A28	130	221	19	289	Chain	ID=PRO_0000042233;Note=SLAM family member 9
SLAMF9	Q96A28	130	221	19	236	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF9	Q96A28	130	221	136	210	Domain	Note=Ig-like C2-type
SLAMF9	Q96A28	130	221	208	208	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLAMF9	Q96A28	130	221	156	200	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
SLAMF9	Q96A28	130	221	131	131	Alternative sequence	ID=VSP_015819;Note=In isoform 2. R->H;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SLAMF9	Q96A28	130	221	132	222	Alternative sequence	ID=VSP_015820;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
SLAMF9	Q96A28	130	221	164	164	Natural variant	ID=VAR_032813;Note=D->H;Dbxref=dbSNP:rs35438196
SLAMF9	Q96A28	130	221	181	181	Natural variant	ID=VAR_032814;Note=E->K;Dbxref=dbSNP:rs34884993
SLAIN1	Q8ND83	283	397	1	568	Chain	ID=PRO_0000316962;Note=SLAIN motif-containing protein 1
SLAIN1	Q8ND83	283	397	284	397	Alternative sequence	ID=VSP_043256;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
SLAIN2	Q9P270	179	234	1	581	Chain	ID=PRO_0000316965;Note=SLAIN motif-containing protein 2
SLAIN2	Q9P270	234	287	1	581	Chain	ID=PRO_0000316965;Note=SLAIN motif-containing protein 2
SLAIN2	Q9P270	287	407	1	581	Chain	ID=PRO_0000316965;Note=SLAIN motif-containing protein 2
SLAIN2	Q9P270	179	234	179	179	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SLAIN2	Q9P270	234	287	247	247	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SLAIN2	Q9P270	234	287	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SLAIN2	Q9P270	234	287	251	251	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SLAIN2	Q9P270	234	287	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
SLAIN2	Q9P270	287	407	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLAIN2	Q9P270	287	407	323	323	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SLAIN2	Q9P270	287	407	377	377	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
SLAIN2	Q9P270	287	407	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
SLAIN2	Q9P270	179	234	233	233	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLPI	P03973	81	131	26	132	Chain	ID=PRO_0000041355;Note=Antileukoproteinase
SLPI	P03973	81	131	82	130	Domain	Note=WAP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
SLPI	P03973	81	131	84	132	Region	Note=Elastase inhibitory domain
SLPI	P03973	81	131	97	98	Site	Note=Reactive bond for chymotrypsin%2C trypsin and elastase;Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:18421166,ECO:0000305|PubMed:24121345,ECO:0000305|PubMed:3366116;Dbxref=PMID:18421166,PMID:24121345,PMID:3366116
SLPI	P03973	81	131	89	118	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2Z7F,ECO:0000244|PDB:4DOQ,ECO:0000269|PubMed:3366116;Dbxref=PMID:3366116
SLPI	P03973	81	131	96	122	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2Z7F,ECO:0000244|PDB:4DOQ,ECO:0000269|PubMed:3366116;Dbxref=PMID:3366116
SLPI	P03973	81	131	105	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2Z7F,ECO:0000244|PDB:4DOQ,ECO:0000269|PubMed:3366116;Dbxref=PMID:3366116
SLPI	P03973	81	131	111	126	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2Z7F,ECO:0000244|PDB:4DOQ,ECO:0000269|PubMed:3366116;Dbxref=PMID:3366116
SLPI	P03973	81	131	97	97	Mutagenesis	Note=Increases inhibition of chymotrypsin. L->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2110563;Dbxref=PMID:10702419,PMID:2110563
SLPI	P03973	81	131	97	97	Mutagenesis	Note=Reduced inhibition of elastase. Strongly reduced inhibition of chymotrypsin and trypsin. L->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2110563;Dbxref=PMID:10702419,PMID:2110563
SLPI	P03973	81	131	97	97	Mutagenesis	Note=Strongly reduced inhibition of elastase. Abolishes inhibition of trypsin. L->K%2CR;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2110563;Dbxref=PMID:10702419,PMID:2110563
SLPI	P03973	81	131	98	98	Mutagenesis	Note=No significant effect on inhibition of elastase%2C trypsin and chymotrypsin. M->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2110563;Dbxref=PMID:2110563
SLPI	P03973	81	131	99	99	Mutagenesis	Note=No significant effect on inhibition of elastase%2C trypsin and chymotrypsin. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2110563;Dbxref=PMID:2110563
SLPI	P03973	81	131	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z7F
SLPI	P03973	81	131	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z7F
SLPI	P03973	81	131	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z7F
SLPI	P03973	81	131	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z7F
SLPI	P03973	81	131	123	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z7F
SNX10	Q9Y5X0	8	37	1	201	Chain	ID=PRO_0000213854;Note=Sorting nexin-10
SNX10	Q9Y5X0	8	37	1	201	Chain	ID=PRO_0000213854;Note=Sorting nexin-10
SNX10	Q9Y5X0	8	37	10	127	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX10	Q9Y5X0	8	37	10	127	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
SNX10	Q9Y5X0	8	37	8	125	Region	Note=Required for interaction with ATP6V1D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21844891;Dbxref=PMID:21844891
SNX10	Q9Y5X0	8	37	8	125	Region	Note=Required for interaction with ATP6V1D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21844891;Dbxref=PMID:21844891
SNX10	Q9Y5X0	8	37	1	84	Alternative sequence	ID=VSP_045920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNX10	Q9Y5X0	8	37	1	84	Alternative sequence	ID=VSP_045920;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNX10	Q9Y5X0	8	37	16	16	Natural variant	ID=VAR_069299;Note=In OPTB8. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23280965;Dbxref=dbSNP:rs779298714,PMID:23280965
SNX10	Q9Y5X0	8	37	16	16	Natural variant	ID=VAR_069299;Note=In OPTB8. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23280965;Dbxref=dbSNP:rs779298714,PMID:23280965
SNX10	Q9Y5X0	8	37	32	32	Natural variant	ID=VAR_069300;Note=In OPTB8. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23280965;Dbxref=dbSNP:rs771038257,PMID:23280965
SNX10	Q9Y5X0	8	37	32	32	Natural variant	ID=VAR_069300;Note=In OPTB8. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23280965;Dbxref=dbSNP:rs771038257,PMID:23280965
SNX10	Q9Y5X0	8	37	11	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ON3
SNX10	Q9Y5X0	8	37	11	22	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ON3
SNX10	Q9Y5X0	8	37	25	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PZG
SNX10	Q9Y5X0	8	37	25	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PZG
SNX10	Q9Y5X0	8	37	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ON3
SNX10	Q9Y5X0	8	37	29	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ON3
SNX31	Q8N9S9	390	409	1	440	Chain	ID=PRO_0000331603;Note=Sorting nexin-31
SNX31	Q8N9S9	326	364	1	440	Chain	ID=PRO_0000331603;Note=Sorting nexin-31
SNX31	Q8N9S9	258	326	1	440	Chain	ID=PRO_0000331603;Note=Sorting nexin-31
SNX31	Q8N9S9	258	326	309	309	Natural variant	ID=VAR_042901;Note=Q->R;Dbxref=dbSNP:rs2248609
SNX31	Q8N9S9	326	364	338	338	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPATA5L1	Q9BVQ7	478	548	1	753	Chain	ID=PRO_0000330586;Note=Spermatogenesis-associated protein 5-like protein 1
SPATA5L1	Q9BVQ7	478	548	505	512	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPATA5L1	Q9BVQ7	478	548	393	753	Alternative sequence	ID=VSP_033051;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	864	917	1	1298	Chain	ID=PRO_0000208026;Note=TBC1 domain family member 4
TBC1D4	O60343	678	732	1	1298	Chain	ID=PRO_0000208026;Note=TBC1 domain family member 4
TBC1D4	O60343	577	602	1	1298	Chain	ID=PRO_0000208026;Note=TBC1 domain family member 4
TBC1D4	O60343	500	537	1	1298	Chain	ID=PRO_0000208026;Note=TBC1 domain family member 4
TBC1D4	O60343	390	425	1	1298	Chain	ID=PRO_0000208026;Note=TBC1 domain family member 4
TBC1D4	O60343	360	390	1	1298	Chain	ID=PRO_0000208026;Note=TBC1 domain family member 4
TBC1D4	O60343	390	425	312	468	Domain	Note=PID 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
TBC1D4	O60343	360	390	312	468	Domain	Note=PID 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
TBC1D4	O60343	678	732	672	759	Compositional bias	Note=Ser-rich
TBC1D4	O60343	577	602	577	577	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BYJ6
TBC1D4	O60343	577	602	588	588	Modified residue	Note=Phosphoserine%3B by PKB/AKT1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:11994271;Dbxref=PMID:16964243,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569,PMID:11994271
TBC1D4	O60343	577	602	591	591	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:21406692,PMID:23186163,PMID:24275569
TBC1D4	O60343	678	732	1	783	Alternative sequence	ID=VSP_036868;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	577	602	1	783	Alternative sequence	ID=VSP_036868;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	500	537	1	783	Alternative sequence	ID=VSP_036868;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	390	425	1	783	Alternative sequence	ID=VSP_036868;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	360	390	1	783	Alternative sequence	ID=VSP_036868;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	678	732	678	740	Alternative sequence	ID=VSP_036869;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18771725;Dbxref=PMID:18771725
TBC1D4	O60343	864	917	865	917	Alternative sequence	ID=VSP_036871;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D4	O60343	577	602	588	588	Mutagenesis	Note=80%25 reduction of insulin-stimulated GLUT4 translocation%3B when associated with A-318%3B A-642 and A-751. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12637568;Dbxref=PMID:12637568
TBC1D4	O60343	864	917	864	864	Sequence conflict	Note=E->EG;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D4	O60343	864	917	864	864	Sequence conflict	Note=E->EG;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D4	O60343	864	917	864	864	Sequence conflict	Note=E->EG;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D4	O60343	864	917	867	867	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D4	O60343	864	917	874	877	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYB
TBC1D4	O60343	864	917	887	896	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYB
TBC1D4	O60343	864	917	908	917	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYB
MRPS16	Q9Y3D3	4	91	1	34	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRPS16	Q9Y3D3	4	91	35	137	Chain	ID=PRO_0000030618;Note=28S ribosomal protein S16%2C mitochondrial
MRPS16	Q9Y3D3	4	91	12	12	Natural variant	ID=VAR_031525;Note=Y->H;Dbxref=dbSNP:rs7905009
RTN1	Q16799	338	588	1	776	Chain	ID=PRO_0000168158;Note=Reticulon-1
RTN1	Q16799	338	588	350	350	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K0T0
RTN1	Q16799	338	588	352	352	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K0T0
RTN1	Q16799	338	588	487	487	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:24275569;Dbxref=PMID:18088087,PMID:24275569
RTN1	Q16799	338	588	1	568	Alternative sequence	ID=VSP_005645;Note=In isoform RTN1-C. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7685762;Dbxref=PMID:15489334,PMID:7685762
RTN1	Q16799	338	588	1	420	Alternative sequence	ID=VSP_005644;Note=In isoform RTN1-B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685762;Dbxref=PMID:7685762
RTN1	Q16799	338	588	569	588	Alternative sequence	ID=VSP_005646;Note=In isoform RTN1-C. GPGPLGPGAPPPLLFLNKQK->MQATADSTKMDCVWSNWKSQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7685762;Dbxref=PMID:15489334,PMID:7685762
RTN1	Q16799	338	588	357	357	Natural variant	ID=VAR_053631;Note=I->V;Dbxref=dbSNP:rs35707243
TBX19	O60806	242	305	1	448	Chain	ID=PRO_0000184449;Note=T-box transcription factor TBX19
RPUSD3	Q6P087	136	171	26	351	Chain	ID=PRO_0000300822;Note=Mitochondrial mRNA pseudouridine synthase RPUSD3
RPUSD3	Q6P087	87	102	26	351	Chain	ID=PRO_0000300822;Note=Mitochondrial mRNA pseudouridine synthase RPUSD3
RPUSD3	Q6P087	87	102	89	103	Alternative sequence	ID=VSP_027870;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPUSD3	Q6P087	136	171	137	351	Alternative sequence	ID=VSP_027869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBX20	Q9UMR3	127	181	1	447	Chain	ID=PRO_0000184451;Note=T-box transcription factor TBX20
TBX20	Q9UMR3	127	181	109	288	DNA binding	Note=T-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00201
TBX20	Q9UMR3	127	181	152	152	Natural variant	ID=VAR_036995;Note=In ASD4%3B gain of function in sequence-specific DNA binding transcription factor activity%3B gain of function in sequence-specific DNA binding transcription factor activity in the presence of cotranscription factors NKX2-5 and GATA4 or GATA5. I->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17668378,ECO:0000269|PubMed:19762328;Dbxref=dbSNP:rs137852954,PMID:17668378,PMID:19762328
TBX2	Q13207	221	270	1	712	Chain	ID=PRO_0000184426;Note=T-box transcription factor TBX2
TBX2	Q13207	221	270	109	287	DNA binding	Note=T-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00201
CCT4	P50991	497	535	2	539	Chain	ID=PRO_0000128332;Note=T-complex protein 1 subunit delta
CCT4	P50991	338	375	2	539	Chain	ID=PRO_0000128332;Note=T-complex protein 1 subunit delta
CCT4	P50991	60	90	2	539	Chain	ID=PRO_0000128332;Note=T-complex protein 1 subunit delta
CCT4	P50991	60	90	60	89	Alternative sequence	ID=VSP_045537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT4	P50991	497	535	531	531	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT5	P48643	55	110	2	541	Chain	ID=PRO_0000128346;Note=T-complex protein 1 subunit epsilon
CCT5	P48643	291	331	2	541	Chain	ID=PRO_0000128346;Note=T-complex protein 1 subunit epsilon
CCT5	P48643	331	393	2	541	Chain	ID=PRO_0000128346;Note=T-complex protein 1 subunit epsilon
CCT5	P48643	393	439	2	541	Chain	ID=PRO_0000128346;Note=T-complex protein 1 subunit epsilon
CCT5	P48643	331	393	346	346	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCT5	P48643	331	393	392	392	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CCT5	P48643	55	110	56	110	Alternative sequence	ID=VSP_054006;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT5	P48643	55	110	55	55	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT5	P48643	55	110	74	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	55	110	86	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	55	110	107	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	291	331	271	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	291	331	298	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	291	331	308	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	291	331	316	318	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	291	331	328	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	291	331	331	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	331	393	331	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	331	393	350	352	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	331	393	356	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	331	393	367	374	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	331	393	383	387	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	331	393	391	393	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	393	439	391	393	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	393	439	394	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	393	439	421	423	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT5	P48643	393	439	424	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYX
CCT7	Q99832	89	131	1	543	Chain	ID=PRO_0000128365;Note=T-complex protein 1 subunit eta
CCT7	Q99832	261	324	1	543	Chain	ID=PRO_0000128365;Note=T-complex protein 1 subunit eta
CCT7	Q99832	401	470	1	543	Chain	ID=PRO_0000128365;Note=T-complex protein 1 subunit eta
CCT7	Q99832	89	131	2	543	Chain	ID=PRO_0000434391;Note=T-complex protein 1 subunit eta%2C N-terminally processed
CCT7	Q99832	261	324	2	543	Chain	ID=PRO_0000434391;Note=T-complex protein 1 subunit eta%2C N-terminally processed
CCT7	Q99832	401	470	2	543	Chain	ID=PRO_0000434391;Note=T-complex protein 1 subunit eta%2C N-terminally processed
CCT7	Q99832	261	324	320	320	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CCT7	Q99832	401	470	430	430	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CCT7	Q99832	89	131	3	89	Alternative sequence	ID=VSP_043573;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT7	Q99832	89	131	90	206	Alternative sequence	ID=VSP_043574;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT7	Q99832	261	324	282	283	Sequence conflict	Note=HH->RQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT7	Q99832	261	324	293	293	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT7	Q99832	401	470	407	407	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT7	Q99832	401	470	411	411	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TECPR1	Q7Z6L1	1088	1128	1	1165	Chain	ID=PRO_0000337060;Note=Tectonin beta-propeller repeat-containing protein 1
TECPR1	Q7Z6L1	1021	1052	1	1165	Chain	ID=PRO_0000337060;Note=Tectonin beta-propeller repeat-containing protein 1
TECPR1	Q7Z6L1	897	915	1	1165	Chain	ID=PRO_0000337060;Note=Tectonin beta-propeller repeat-containing protein 1
TECPR1	Q7Z6L1	311	345	1	1165	Chain	ID=PRO_0000337060;Note=Tectonin beta-propeller repeat-containing protein 1
TECPR1	Q7Z6L1	75	136	1	1165	Chain	ID=PRO_0000337060;Note=Tectonin beta-propeller repeat-containing protein 1
TECPR1	Q7Z6L1	311	345	301	332	Repeat	Note=TECPR 3
TECPR1	Q7Z6L1	311	345	344	376	Repeat	Note=TECPR 4
TECPR1	Q7Z6L1	1021	1052	998	1029	Repeat	Note=TECPR 7
TECPR1	Q7Z6L1	1021	1052	1044	1075	Repeat	Note=TECPR 8
TECPR1	Q7Z6L1	1088	1128	1087	1127	Repeat	Note=TECPR 9
TECPR1	Q7Z6L1	75	136	1	79	Alternative sequence	ID=VSP_042969;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TECPR1	Q7Z6L1	1088	1128	838	1165	Alternative sequence	ID=VSP_042973;Note=In isoform 3. RGLPTDRYMWSDASGLQECTKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYHGSKTMKDFVRRRCWARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSDKGDVLCRLGVSELNPAGSSWLHVGTDQPFASISIGACYQVWAVARDGSAFYRGSVYPSQPAGDCWYHIPSPPRQRLKQVSAGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCRVSVGPLDQVWVIANKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANATRAPRSSSQEQEPSAPPEAHGPVCC->SRDRISPCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TECPR1	Q7Z6L1	1021	1052	838	1165	Alternative sequence	ID=VSP_042973;Note=In isoform 3. RGLPTDRYMWSDASGLQECTKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYHGSKTMKDFVRRRCWARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSDKGDVLCRLGVSELNPAGSSWLHVGTDQPFASISIGACYQVWAVARDGSAFYRGSVYPSQPAGDCWYHIPSPPRQRLKQVSAGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCRVSVGPLDQVWVIANKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANATRAPRSSSQEQEPSAPPEAHGPVCC->SRDRISPCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TECPR1	Q7Z6L1	897	915	838	1165	Alternative sequence	ID=VSP_042973;Note=In isoform 3. RGLPTDRYMWSDASGLQECTKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYHGSKTMKDFVRRRCWARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSDKGDVLCRLGVSELNPAGSSWLHVGTDQPFASISIGACYQVWAVARDGSAFYRGSVYPSQPAGDCWYHIPSPPRQRLKQVSAGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCRVSVGPLDQVWVIANKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANATRAPRSSSQEQEPSAPPEAHGPVCC->SRDRISPCW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TECPR1	Q7Z6L1	75	136	116	116	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT6B	Q92526	205	241	1	530	Chain	ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2
CCT6B	Q92526	67	112	1	530	Chain	ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2
CCT6B	Q92526	67	112	68	112	Alternative sequence	ID=VSP_043040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT6B	Q92526	205	241	206	242	Alternative sequence	ID=VSP_047129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCT6B	Q92526	67	112	86	86	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT6B	Q92526	67	112	94	94	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCT6A	P40227	67	112	2	531	Chain	ID=PRO_0000128355;Note=T-complex protein 1 subunit zeta
CCT6A	P40227	67	112	68	112	Alternative sequence	ID=VSP_044918;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPS27	P42677	38	75	2	84	Chain	ID=PRO_0000149051;Note=40S ribosomal protein S27
RPS27	P42677	38	75	37	59	Zinc finger	Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPS4X	P62701	1	27	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8706699;Dbxref=PMID:8706699
RPS4X	P62701	1	27	2	263	Chain	ID=PRO_0000130805;Note=40S ribosomal protein S4%2C X isoform
TATDN1	Q6P1N9	67	115	1	297	Chain	ID=PRO_0000313590;Note=Putative deoxyribonuclease TATDN1
TATDN1	Q6P1N9	7	29	1	297	Chain	ID=PRO_0000313590;Note=Putative deoxyribonuclease TATDN1
TATDN1	Q6P1N9	67	115	112	112	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
TATDN1	Q6P1N9	67	115	112	112	Metal binding	Note=Divalent metal cation 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
TATDN1	Q6P1N9	7	29	27	27	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6P8M1
TATDN1	Q6P1N9	7	29	1	47	Alternative sequence	ID=VSP_030045;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TATDN1	Q6P1N9	7	29	6	11	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	7	29	16	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	67	115	70	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	67	115	78	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	67	115	83	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	67	115	89	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	67	115	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
TATDN1	Q6P1N9	67	115	107	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XIO
RSBN1L	Q6PCB5	448	494	2	846	Chain	ID=PRO_0000299414;Note=Round spermatid basic protein 1-like protein
RSAD2	Q8WXG1	115	169	1	361	Chain	ID=PRO_0000309583;Note=Radical S-adenosyl methionine domain-containing protein 2
RNF43	Q68DV7	150	194	24	783	Chain	ID=PRO_0000278239;Note=E3 ubiquitin-protein ligase RNF43
RNF43	Q68DV7	84	125	24	783	Chain	ID=PRO_0000278239;Note=E3 ubiquitin-protein ligase RNF43
RNF43	Q68DV7	150	194	24	783	Chain	ID=PRO_0000278239;Note=E3 ubiquitin-protein ligase RNF43
RNF43	Q68DV7	84	125	24	783	Chain	ID=PRO_0000278239;Note=E3 ubiquitin-protein ligase RNF43
RNF43	Q68DV7	150	194	24	783	Chain	ID=PRO_0000278239;Note=E3 ubiquitin-protein ligase RNF43
RNF43	Q68DV7	84	125	24	783	Chain	ID=PRO_0000278239;Note=E3 ubiquitin-protein ligase RNF43
RNF43	Q68DV7	150	194	24	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	24	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	150	194	24	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	24	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	150	194	24	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	24	197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	92	92	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	92	92	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	92	92	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
RNF43	Q68DV7	84	125	91	119	Disulfide bond	.
RNF43	Q68DV7	84	125	91	119	Disulfide bond	.
RNF43	Q68DV7	84	125	91	119	Disulfide bond	.
RNF43	Q68DV7	84	125	1	127	Alternative sequence	ID=VSP_037338;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF43	Q68DV7	84	125	1	127	Alternative sequence	ID=VSP_037338;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF43	Q68DV7	84	125	1	127	Alternative sequence	ID=VSP_037338;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF43	Q68DV7	84	125	85	125	Alternative sequence	ID=VSP_037339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF43	Q68DV7	84	125	85	125	Alternative sequence	ID=VSP_037339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF43	Q68DV7	84	125	85	125	Alternative sequence	ID=VSP_037339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RNF43	Q68DV7	84	125	117	117	Natural variant	ID=VAR_030714;Note=R->H;Dbxref=dbSNP:rs2257205
RNF43	Q68DV7	84	125	117	117	Natural variant	ID=VAR_030714;Note=R->H;Dbxref=dbSNP:rs2257205
RNF43	Q68DV7	84	125	117	117	Natural variant	ID=VAR_030714;Note=R->H;Dbxref=dbSNP:rs2257205
RNF43	Q68DV7	84	125	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	78	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	104	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	104	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	104	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	112	114	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	112	114	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	112	114	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	122	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	122	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	84	125	122	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	147	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	147	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	147	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	157	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	157	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	157	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	166	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	166	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	166	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	177	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	184	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	184	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF43	Q68DV7	150	194	184	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNG
RNF44	Q7L0R7	155	213	1	432	Chain	ID=PRO_0000273413;Note=RING finger protein 44
RNF44	Q7L0R7	155	213	12	321	Compositional bias	Note=Pro-rich
RAP1GAP	P47736	513	550	1	663	Chain	ID=PRO_0000056743;Note=Rap1 GTPase-activating protein 1
RAP1GAP	P47736	386	432	1	663	Chain	ID=PRO_0000056743;Note=Rap1 GTPase-activating protein 1
RAP1GAP	P47736	333	357	1	663	Chain	ID=PRO_0000056743;Note=Rap1 GTPase-activating protein 1
RAP1GAP	P47736	281	333	1	663	Chain	ID=PRO_0000056743;Note=Rap1 GTPase-activating protein 1
RAP1GAP	P47736	176	204	1	663	Chain	ID=PRO_0000056743;Note=Rap1 GTPase-activating protein 1
RAP1GAP	P47736	22	35	1	663	Chain	ID=PRO_0000056743;Note=Rap1 GTPase-activating protein 1
RAP1GAP	P47736	386	432	181	397	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP	P47736	333	357	181	397	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP	P47736	281	333	181	397	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP	P47736	176	204	181	397	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP	P47736	513	550	515	515	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RAP1GAP	P47736	513	550	541	541	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2ALS5
RAP1GAP	P47736	513	550	542	542	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2ALS5
RAP1GAP	P47736	281	333	286	286	Mutagenesis	Note=Reduces GTPase activation. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15141215;Dbxref=PMID:15141215
RAP1GAP	P47736	281	333	287	287	Mutagenesis	Note=Abolishes GTPase activation. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15141215;Dbxref=PMID:15141215
RAP1GAP	P47736	281	333	290	290	Mutagenesis	Note=Abolishes GTPase activation. N->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15141215;Dbxref=PMID:15141215
RAP1GAP	P47736	281	333	291	291	Mutagenesis	Note=Abolishes GTPase activation. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15141215;Dbxref=PMID:15141215
RAP1GAP	P47736	386	432	388	388	Mutagenesis	Note=Reduces GTPase activation. R->A%2CP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15141215;Dbxref=PMID:15141215
RAP1GAP	P47736	281	333	304	304	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAP1GAP	P47736	176	204	177	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	176	204	192	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	281	333	282	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	281	333	292	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	281	333	306	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	281	333	316	323	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	281	333	327	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BRW
RAP1GAP	P47736	333	357	331	338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	281	333	331	338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	333	357	354	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP	P47736	386	432	380	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SRQ
RAP1GAP2	Q684P5	67	82	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	243	271	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	400	424	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	498	544	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	67	82	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	243	271	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	400	424	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	498	544	1	730	Chain	ID=PRO_0000312716;Note=Rap1 GTPase-activating protein 2
RAP1GAP2	Q684P5	243	271	248	464	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP2	Q684P5	400	424	248	464	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP2	Q684P5	243	271	248	464	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP2	Q684P5	400	424	248	464	Domain	Note=Rap-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00165
RAP1GAP2	Q684P5	498	544	507	507	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SVL6
RAP1GAP2	Q684P5	498	544	507	507	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5SVL6
RAP1GAP2	Q684P5	498	544	544	544	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332;Dbxref=PMID:16964243,PMID:19690332
RAP1GAP2	Q684P5	498	544	544	544	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332;Dbxref=PMID:16964243,PMID:19690332
RAP1GAP2	Q684P5	67	82	68	82	Alternative sequence	ID=VSP_029889;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15632203;Dbxref=PMID:15632203
RAP1GAP2	Q684P5	67	82	68	82	Alternative sequence	ID=VSP_029889;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15632203;Dbxref=PMID:15632203
POLR3H	Q9Y535	69	98	1	204	Chain	ID=PRO_0000073994;Note=DNA-directed RNA polymerase III subunit RPC8
POLR3H	Q9Y535	69	98	1	204	Chain	ID=PRO_0000073994;Note=DNA-directed RNA polymerase III subunit RPC8
POLR3H	Q9Y535	69	98	1	204	Chain	ID=PRO_0000073994;Note=DNA-directed RNA polymerase III subunit RPC8
POLR3H	Q9Y535	69	98	70	98	Alternative sequence	ID=VSP_007067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLR3H	Q9Y535	69	98	70	98	Alternative sequence	ID=VSP_007067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
POLR3H	Q9Y535	69	98	70	98	Alternative sequence	ID=VSP_007067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RAPGEF1	Q13905	50	88	1	1077	Chain	ID=PRO_0000068864;Note=Rap guanine nucleotide exchange factor 1
RAPGEF1	Q13905	50	88	50	88	Alternative sequence	ID=VSP_001822;Note=In isoform Short. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RAPGEF4	Q8WZA2	179	197	1	1011	Chain	ID=PRO_0000068870;Note=Rap guanine nucleotide exchange factor 4
RAPGEF4	Q8WZA2	669	718	1	1011	Chain	ID=PRO_0000068870;Note=Rap guanine nucleotide exchange factor 4
RAPGEF4	Q8WZA2	179	197	1	315	Alternative sequence	ID=VSP_007611;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707077;Dbxref=PMID:11707077
RAPGEF4	Q8WZA2	179	197	180	197	Alternative sequence	ID=VSP_054424;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RAPGEF4	Q8WZA2	669	718	679	679	Sequence conflict	Note=H->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SMURF2	Q9HAU4	286	338	1	748	Chain	ID=PRO_0000120329;Note=E3 ubiquitin-protein ligase SMURF2
SMURF2	Q9HAU4	111	133	1	748	Chain	ID=PRO_0000120329;Note=E3 ubiquitin-protein ligase SMURF2
SMURF2	Q9HAU4	17	30	1	748	Chain	ID=PRO_0000120329;Note=E3 ubiquitin-protein ligase SMURF2
SMURF2	Q9HAU4	17	30	1	98	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
SMURF2	Q9HAU4	286	338	297	330	Domain	Note=WW 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224
SMURF2	Q9HAU4	17	30	29	29	Mutagenesis	Note=Increases autoubiquitination%3B when associated with A-30. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17719543;Dbxref=PMID:17719543
SMURF2	Q9HAU4	17	30	30	30	Mutagenesis	Note=Increases autoubiquitination%3B when associated with A-29. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17719543;Dbxref=PMID:17719543
SMURF2	Q9HAU4	286	338	297	330	Mutagenesis	Note=Abolishes interaction with SMAD7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11163210;Dbxref=PMID:11163210
SMURF2	Q9HAU4	17	30	12	23	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JQZ
SMURF2	Q9HAU4	111	133	113	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JQZ
SMURF2	Q9HAU4	111	133	131	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JQZ
SMURF2	Q9HAU4	286	338	286	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KXQ
SMURF2	Q9HAU4	286	338	293	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KXQ
SMURF2	Q9HAU4	286	338	301	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJY
SMURF2	Q9HAU4	286	338	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJY
SMURF2	Q9HAU4	286	338	313	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJY
SMURF2	Q9HAU4	286	338	318	321	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJY
SMURF2	Q9HAU4	286	338	322	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJY
SMURF2	Q9HAU4	286	338	328	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DJY
SMYD2	Q9NRG4	79	116	1	433	Chain	ID=PRO_0000218309;Note=N-lysine methyltransferase SMYD2
SMYD2	Q9NRG4	79	116	7	241	Domain	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190
SMYD2	Q9NRG4	79	116	52	90	Zinc finger	Note=MYND-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134
SMYD2	Q9NRG4	79	116	76	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WUY
SMYD2	Q9NRG4	79	116	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WUY
SMYD2	Q9NRG4	79	116	90	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WUY
SMYD2	Q9NRG4	79	116	97	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WUY
SMYD2	Q9NRG4	79	116	104	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WUY
RRNAD1	Q96FB5	143	164	1	475	Chain	ID=PRO_0000289052;Note=Protein RRNAD1
RRP12	Q5JTH9	1130	1172	1	1297	Chain	ID=PRO_0000050768;Note=RRP12-like protein
RRP12	Q5JTH9	896	932	1	1297	Chain	ID=PRO_0000050768;Note=RRP12-like protein
RRP12	Q5JTH9	212	251	1	1297	Chain	ID=PRO_0000050768;Note=RRP12-like protein
RRP12	Q5JTH9	123	151	1	1297	Chain	ID=PRO_0000050768;Note=RRP12-like protein
RRP12	Q5JTH9	848	890	1	1297	Chain	ID=PRO_0000050768;Note=RRP12-like protein
RRP12	Q5JTH9	614	650	1	1297	Chain	ID=PRO_0000050768;Note=RRP12-like protein
RRP12	Q5JTH9	896	932	903	923	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
RRP12	Q5JTH9	212	251	152	251	Alternative sequence	ID=VSP_014798;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9734811;Dbxref=PMID:9734811
RRP12	Q5JTH9	212	251	152	212	Alternative sequence	ID=VSP_045674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RRP12	Q5JTH9	1130	1172	1145	1145	Natural variant	ID=VAR_057756;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9734811;Dbxref=dbSNP:rs2275580,PMID:14702039,PMID:15489334,PMID:9734811
RRP12	Q5JTH9	212	251	249	249	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAPA	P54920	245	262	1	295	Chain	ID=PRO_0000219056;Note=Alpha-soluble NSF attachment protein
NAPA	P54920	222	245	1	295	Chain	ID=PRO_0000219056;Note=Alpha-soluble NSF attachment protein
NAPA	P54920	187	222	1	295	Chain	ID=PRO_0000219056;Note=Alpha-soluble NSF attachment protein
NAPA	P54920	114	140	1	295	Chain	ID=PRO_0000219056;Note=Alpha-soluble NSF attachment protein
NAPA	P54920	59	98	1	295	Chain	ID=PRO_0000219056;Note=Alpha-soluble NSF attachment protein
NAPA	P54920	187	222	195	195	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NAPA	P54920	114	140	122	122	Mutagenesis	Note=Does not affect interaction with GNA12. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15980433;Dbxref=PMID:15980433
NAPA	P54920	114	140	140	140	Mutagenesis	Note=Increases interaction with GNA12. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15980433;Dbxref=PMID:15980433
NAPA	P54920	187	222	195	195	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS11	P62280	5	49	2	158	Chain	ID=PRO_0000128509;Note=40S ribosomal protein S11
RPS11	P62280	5	49	22	22	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPS11	P62280	5	49	38	38	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS11	P62280	5	49	45	45	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
SNAP23	O00161	19	33	1	211	Chain	ID=PRO_0000213598;Note=Synaptosomal-associated protein 23
SNAP23	O00161	89	141	1	211	Chain	ID=PRO_0000213598;Note=Synaptosomal-associated protein 23
SNAP23	O00161	19	33	14	76	Domain	Note=t-SNARE coiled-coil homology 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
SNAP23	O00161	19	33	23	76	Coiled coil	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12556468;Dbxref=PMID:12556468
SNAP23	O00161	19	33	20	20	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
SNAP23	O00161	19	33	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O09044
SNAP23	O00161	89	141	110	110	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
SNAP23	O00161	89	141	112	112	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21044946;Dbxref=PMID:21044946
SNAP23	O00161	89	141	89	89	Alternative sequence	ID=VSP_006187;Note=In isoform SNAP-23b. R->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9070898;Dbxref=PMID:9070898
SNAP23	O00161	89	141	90	142	Alternative sequence	ID=VSP_006188;Note=In isoform SNAP-23b. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9070898;Dbxref=PMID:9070898
SNAP23	O00161	89	141	135	135	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNAP23	O00161	19	33	24	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NHL
SNAPC2	Q13487	101	124	1	334	Chain	ID=PRO_0000072020;Note=snRNA-activating protein complex subunit 2
SNAPC2	Q13487	101	124	118	118	Natural variant	ID=VAR_011806;Note=L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.4;Dbxref=dbSNP:rs475002,PMID:14702039
SNAPC5	O75971	30	60	1	98	Chain	ID=PRO_0000072028;Note=snRNA-activating protein complex subunit 5
SNAPC5	O75971	30	60	1	98	Chain	ID=PRO_0000072028;Note=snRNA-activating protein complex subunit 5
SNAPC5	O75971	30	60	31	60	Alternative sequence	ID=VSP_012785;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SNAPC5	O75971	30	60	31	60	Alternative sequence	ID=VSP_012785;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
SNRK	Q9NRH2	244	314	1	765	Chain	ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRK	Q9NRH2	244	314	1	765	Chain	ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRK	Q9NRH2	244	314	1	765	Chain	ID=PRO_0000225605;Note=SNF-related serine/threonine-protein kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRK	Q9NRH2	244	314	16	269	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SNRK	Q9NRH2	244	314	16	269	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SNRK	Q9NRH2	244	314	16	269	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
SNRK	Q9NRH2	244	314	291	334	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
SNRK	Q9NRH2	244	314	291	334	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
SNRK	Q9NRH2	244	314	291	334	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
SNRK	Q9NRH2	244	314	244	244	Alternative sequence	ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRK	Q9NRH2	244	314	244	244	Alternative sequence	ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRK	Q9NRH2	244	314	244	244	Alternative sequence	ID=VSP_051959;Note=In isoform 2. D->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRK	Q9NRH2	244	314	245	765	Alternative sequence	ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRK	Q9NRH2	244	314	245	765	Alternative sequence	ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRK	Q9NRH2	244	314	245	765	Alternative sequence	ID=VSP_051960;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRK	Q9NRH2	244	314	260	260	Natural variant	ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846
SNRK	Q9NRH2	244	314	260	260	Natural variant	ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846
SNRK	Q9NRH2	244	314	260	260	Natural variant	ID=VAR_041096;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35624204,PMID:17344846
SNRK	Q9NRH2	244	314	259	259	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRK	Q9NRH2	244	314	259	259	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRK	Q9NRH2	244	314	259	259	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRK	Q9NRH2	244	314	240	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	240	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	240	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	254	256	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	254	256	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	254	256	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	260	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	260	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	260	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	267	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	284	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	284	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	284	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	292	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	292	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	292	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	310	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	310	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNRK	Q9NRH2	244	314	310	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YKS
SNTG2	Q9NY99	296	335	1	539	Chain	ID=PRO_0000184015;Note=Gamma-2-syntrophin
SNTG2	Q9NY99	428	459	1	539	Chain	ID=PRO_0000184015;Note=Gamma-2-syntrophin
SNTG2	Q9NY99	296	335	296	421	Domain	Note=PH
TBC1D7	Q9P0N9	127	173	1	293	Chain	ID=PRO_0000208031;Note=TBC1 domain family member 7
TBC1D7	Q9P0N9	37	64	1	293	Chain	ID=PRO_0000208031;Note=TBC1 domain family member 7
TBC1D7	Q9P0N9	127	173	1	293	Chain	ID=PRO_0000208031;Note=TBC1 domain family member 7
TBC1D7	Q9P0N9	37	64	1	293	Chain	ID=PRO_0000208031;Note=TBC1 domain family member 7
TBC1D7	Q9P0N9	127	173	50	231	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D7	Q9P0N9	37	64	50	231	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D7	Q9P0N9	127	173	50	231	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D7	Q9P0N9	37	64	50	231	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D7	Q9P0N9	37	64	1	73	Alternative sequence	ID=VSP_044186;Note=In isoform 3. MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHES->MEGASRNLASTPRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D7	Q9P0N9	37	64	1	73	Alternative sequence	ID=VSP_044186;Note=In isoform 3. MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHES->MEGASRNLASTPRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D7	Q9P0N9	37	64	38	64	Alternative sequence	ID=VSP_041480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TBC1D7	Q9P0N9	37	64	38	64	Alternative sequence	ID=VSP_041480;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TBC1D7	Q9P0N9	127	173	127	172	Alternative sequence	ID=VSP_044892;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
TBC1D7	Q9P0N9	127	173	127	172	Alternative sequence	ID=VSP_044892;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
TBC1D7	Q9P0N9	127	173	136	136	Natural variant	ID=VAR_052538;Note=A->T;Dbxref=dbSNP:rs9381921
TBC1D7	Q9P0N9	127	173	136	136	Natural variant	ID=VAR_052538;Note=A->T;Dbxref=dbSNP:rs9381921
TBC1D7	Q9P0N9	37	64	59	59	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D7	Q9P0N9	37	64	59	59	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D7	Q9P0N9	37	64	39	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	37	64	39	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	37	64	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	37	64	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	129	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	148	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	148	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	164	169	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	164	169	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	170	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	173	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D7	Q9P0N9	127	173	173	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QWL
TBC1D9	Q6ZT07	966	991	1	1266	Chain	ID=PRO_0000288499;Note=TBC1 domain family member 9
TBC1D9	Q6ZT07	915	937	1	1266	Chain	ID=PRO_0000288499;Note=TBC1 domain family member 9
TBC1D9	Q6ZT07	353	422	1	1266	Chain	ID=PRO_0000288499;Note=TBC1 domain family member 9
TBC1D9	Q6ZT07	353	422	293	361	Domain	Note=GRAM 2
TBC1D9	Q6ZT07	915	937	886	921	Domain	Note=EF-hand;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
RSRC1	Q96IZ7	107	164	1	334	Chain	ID=PRO_0000097496;Note=Serine/Arginine-related protein 53
RSRC1	Q96IZ7	253	304	1	334	Chain	ID=PRO_0000097496;Note=Serine/Arginine-related protein 53
RSRC1	Q96IZ7	107	164	1	334	Chain	ID=PRO_0000097496;Note=Serine/Arginine-related protein 53
RSRC1	Q96IZ7	253	304	1	334	Chain	ID=PRO_0000097496;Note=Serine/Arginine-related protein 53
RSRC1	Q96IZ7	107	164	3	147	Compositional bias	Note=Arg/Ser-rich
RSRC1	Q96IZ7	107	164	3	147	Compositional bias	Note=Arg/Ser-rich
RSRC1	Q96IZ7	107	164	108	165	Alternative sequence	ID=VSP_013120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RSRC1	Q96IZ7	107	164	108	165	Alternative sequence	ID=VSP_013120;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RSRC1	Q96IZ7	107	164	150	151	Sequence conflict	Note=EK->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
RSRC1	Q96IZ7	107	164	150	151	Sequence conflict	Note=EK->GE;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPS5	P82675	46	92	1	430	Chain	ID=PRO_0000131685;Note=28S ribosomal protein S5%2C mitochondrial
DAP3	P51398	15	56	1	21	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
DAP3	P51398	15	56	1	21	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
DAP3	P51398	15	56	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	56	90	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	201	228	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	301	331	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	15	56	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	56	90	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	201	228	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	301	331	22	398	Chain	ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial
DAP3	P51398	201	228	207	207	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DAP3	P51398	201	228	207	207	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DAP3	P51398	15	56	16	56	Alternative sequence	ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAP3	P51398	56	90	16	56	Alternative sequence	ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAP3	P51398	15	56	16	56	Alternative sequence	ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAP3	P51398	56	90	16	56	Alternative sequence	ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAP3	P51398	56	90	57	90	Alternative sequence	ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAP3	P51398	56	90	57	90	Alternative sequence	ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MRPS22	P82650	216	244	1	360	Chain	ID=PRO_0000087703;Note=28S ribosomal protein S22%2C mitochondrial
MRPS22	P82650	216	244	1	360	Chain	ID=PRO_0000087703;Note=28S ribosomal protein S22%2C mitochondrial
MRPS22	P82650	216	244	170	360	Alternative sequence	ID=VSP_056636;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
MRPS22	P82650	216	244	170	360	Alternative sequence	ID=VSP_056636;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
RTCA	O00442	49	96	1	366	Chain	ID=PRO_0000156410;Note=RNA 3'-terminal phosphate cyclase
RTCA	O00442	298	333	1	366	Chain	ID=PRO_0000156410;Note=RNA 3'-terminal phosphate cyclase
RTCA	O00442	298	333	294	298	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RTCA	O00442	298	333	320	320	Active site	Note=Tele-AMP-histidine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RTCB	Q9Y3I0	393	430	1	505	Chain	ID=PRO_0000255241;Note=tRNA-splicing ligase RtcB homolog
RTCB	Q9Y3I0	393	430	400	403	Nucleotide binding	Note=GMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RTCB	Q9Y3I0	393	430	428	431	Nucleotide binding	Note=GMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RTCB	Q9Y3I0	393	430	428	428	Active site	Note=GMP-histidine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
RTCB	Q9Y3I0	393	430	409	409	Binding site	Note=GMP;Ontology_term=ECO:0000250;evidence=ECO:0000250
RTCB	Q9Y3I0	393	430	427	427	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6	P62753	116	165	1	249	Chain	ID=PRO_0000137312;Note=40S ribosomal protein S6
RPS6	P62753	116	165	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS6	P62753	116	165	144	144	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6	P62753	116	165	155	156	Sequence conflict	Note=QY->EC;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D10C	Q8IV04	84	120	1	446	Chain	ID=PRO_0000284467;Note=Carabin
TBC1D10C	Q8IV04	194	216	1	446	Chain	ID=PRO_0000284467;Note=Carabin
TBC1D10C	Q8IV04	84	120	92	280	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D10C	Q8IV04	194	216	92	280	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D10C	Q8IV04	194	216	157	310	Alternative sequence	ID=VSP_045992;Note=In isoform 2. QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLE->RGSCRCSRPTPCIDRSRATARPRGPWLLCCSCTCPQRRPSGAWCRSVRSTSLGTTGPTWCQSTVPCGADTGAPGAGHCRAARGLPWPPGDTGSPSSHPPRAAAGGGLHVTGAQRGAVRAGPAAGDQGPAGPAARFRAGTPAPATGPPRRGPSHL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TBC1D15	Q8TC07	43	68	2	691	Chain	ID=PRO_0000208042;Note=TBC1 domain family member 15
TBC1D15	Q8TC07	219	236	2	691	Chain	ID=PRO_0000208042;Note=TBC1 domain family member 15
TBC1D15	Q8TC07	411	450	2	691	Chain	ID=PRO_0000208042;Note=TBC1 domain family member 15
TBC1D15	Q8TC07	550	589	2	691	Chain	ID=PRO_0000208042;Note=TBC1 domain family member 15
TBC1D15	Q8TC07	411	450	346	556	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D15	Q8TC07	550	589	346	556	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D15	Q8TC07	219	236	220	236	Alternative sequence	ID=VSP_023094;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:19077034;Dbxref=PMID:14702039,PMID:19077034
TBC1D15	Q8TC07	43	68	52	52	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D23	Q9NUY8	364	421	1	699	Chain	ID=PRO_0000287497;Note=TBC1 domain family member 23
TBC1D23	Q9NUY8	518	532	1	699	Chain	ID=PRO_0000287497;Note=TBC1 domain family member 23
TBC1D23	Q9NUY8	364	421	334	446	Domain	Note=Rhodanese;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00173
TBC1D23	Q9NUY8	518	532	514	699	Region	Note=May mediate the interaction with WASHC1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K0F1
TBC1D23	Q9NUY8	518	532	514	573	Region	Note=May mediate the interaction with C17orf75%2C FAM91A1 and WDR11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K0F1
TBC1D23	Q9NUY8	518	532	520	520	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TBC1D23	Q9NUY8	518	532	518	532	Alternative sequence	ID=VSP_025519;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:19077034;Dbxref=PMID:14702039,PMID:15489334,PMID:19077034
TBC1D23	Q9NUY8	518	532	518	518	Natural variant	ID=VAR_080040;Note=In PCH11%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28823706;Dbxref=PMID:28823706
TBC1D8B	Q0IIM8	345	401	1	1120	Chain	ID=PRO_0000337183;Note=TBC1 domain family member 8B
TBC1D8B	Q0IIM8	401	451	1	1120	Chain	ID=PRO_0000337183;Note=TBC1 domain family member 8B
TBC1D8B	Q0IIM8	751	784	1	1120	Chain	ID=PRO_0000337183;Note=TBC1 domain family member 8B
TBC1D8B	Q0IIM8	784	807	1	1120	Chain	ID=PRO_0000337183;Note=TBC1 domain family member 8B
TBC1D8B	Q0IIM8	345	401	285	353	Domain	Note=GRAM 2
TBC1D8B	Q0IIM8	751	784	633	1120	Alternative sequence	ID=VSP_033954;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:19077034;Dbxref=PMID:14702039,PMID:15489334,PMID:19077034
TBC1D8B	Q0IIM8	784	807	633	1120	Alternative sequence	ID=VSP_033954;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:19077034;Dbxref=PMID:14702039,PMID:15489334,PMID:19077034
SNRPC	P09234	53	83	1	159	Chain	ID=PRO_0000097525;Note=U1 small nuclear ribonucleoprotein C
SNRPC	P09234	83	118	1	159	Chain	ID=PRO_0000097525;Note=U1 small nuclear ribonucleoprotein C
SNRPC	P09234	53	83	63	157	Compositional bias	Note=Met/Pro-rich
SNRPC	P09234	83	118	63	157	Compositional bias	Note=Met/Pro-rich
SNRPC	P09234	83	118	94	98	Sequence conflict	Note=APHMG->TPIW;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRPC	P09234	83	118	101	101	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRPC	P09234	53	83	28	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJO
SNRPC	P09234	53	83	56	59	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VRD
RUNDC3B	Q96NL0	79	96	1	473	Chain	ID=PRO_0000336049;Note=RUN domain-containing protein 3B
RUNDC3B	Q96NL0	336	384	1	473	Chain	ID=PRO_0000336049;Note=RUN domain-containing protein 3B
RUNDC3B	Q96NL0	79	96	57	206	Domain	Note=RUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00178
RUNDC3B	Q96NL0	336	384	317	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RUNDC3B	Q96NL0	79	96	1	259	Alternative sequence	ID=VSP_033803;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RUNDC3B	Q96NL0	79	96	1	95	Alternative sequence	ID=VSP_033804;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12645870;Dbxref=PMID:12645870
RUNDC3B	Q96NL0	79	96	80	96	Alternative sequence	ID=VSP_033805;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
RUNDC3B	Q96NL0	79	96	96	96	Alternative sequence	ID=VSP_033806;Note=In isoform 2. Q->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12645870;Dbxref=PMID:12645870
RUNDC3B	Q96NL0	336	384	337	385	Alternative sequence	ID=VSP_033807;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12645870,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:12645870,PMID:14702039,PMID:15489334
RUSC1	Q9BVN2	805	846	1	902	Chain	ID=PRO_0000097532;Note=RUN and SH3 domain-containing protein 1
RUSC1	Q9BVN2	805	846	844	902	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TCAIM	Q8N3R3	191	231	1	496	Chain	ID=PRO_0000235340;Note=T-cell activation inhibitor%2C mitochondrial
TCAIM	Q8N3R3	373	416	1	496	Chain	ID=PRO_0000235340;Note=T-cell activation inhibitor%2C mitochondrial
TCAIM	Q8N3R3	191	231	1	496	Chain	ID=PRO_0000235340;Note=T-cell activation inhibitor%2C mitochondrial
TCAIM	Q8N3R3	373	416	1	496	Chain	ID=PRO_0000235340;Note=T-cell activation inhibitor%2C mitochondrial
TCAIM	Q8N3R3	373	416	404	437	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCAIM	Q8N3R3	373	416	404	437	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TCAIM	Q8N3R3	191	231	71	496	Alternative sequence	ID=VSP_018470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCAIM	Q8N3R3	373	416	71	496	Alternative sequence	ID=VSP_018470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCAIM	Q8N3R3	191	231	71	496	Alternative sequence	ID=VSP_018470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCAIM	Q8N3R3	373	416	71	496	Alternative sequence	ID=VSP_018470;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCAIM	Q8N3R3	191	231	116	496	Alternative sequence	ID=VSP_018472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCAIM	Q8N3R3	373	416	116	496	Alternative sequence	ID=VSP_018472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCAIM	Q8N3R3	191	231	116	496	Alternative sequence	ID=VSP_018472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCAIM	Q8N3R3	373	416	116	496	Alternative sequence	ID=VSP_018472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAPC3	Q92966	194	244	1	411	Chain	ID=PRO_0000072024;Note=snRNA-activating protein complex subunit 3
SNAPC3	Q92966	272	326	1	411	Chain	ID=PRO_0000072024;Note=snRNA-activating protein complex subunit 3
RPS12	P25398	5	43	2	132	Chain	ID=PRO_0000122323;Note=40S ribosomal protein S12
RPS12	P25398	78	112	2	132	Chain	ID=PRO_0000122323;Note=40S ribosomal protein S12
RPS12	P25398	78	112	99	99	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS5	P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS5	P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS5	P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS5	P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS5	P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS5	P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS5	P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPS5	P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPS5	P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPS5	P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS5	P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS5	P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBCA	O75347	53	82	2	108	Chain	ID=PRO_0000080039;Note=Tubulin-specific chaperone A
TBCA	O75347	53	82	49	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7C
TBCA	O75347	53	82	64	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H7C
TBC1D1	Q86TI0	294	324	1	1168	Chain	ID=PRO_0000208022;Note=TBC1 domain family member 1
TBC1D1	Q86TI0	434	471	1	1168	Chain	ID=PRO_0000208022;Note=TBC1 domain family member 1
TBC1D1	Q86TI0	514	543	1	1168	Chain	ID=PRO_0000208022;Note=TBC1 domain family member 1
TBC1D1	Q86TI0	683	745	1	1168	Chain	ID=PRO_0000208022;Note=TBC1 domain family member 1
TBC1D1	Q86TI0	745	799	1	1168	Chain	ID=PRO_0000208022;Note=TBC1 domain family member 1
TBC1D1	Q86TI0	1044	1102	1	1168	Chain	ID=PRO_0000208022;Note=TBC1 domain family member 1
TBC1D1	Q86TI0	294	324	246	404	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
TBC1D1	Q86TI0	514	543	525	525	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60949
TBC1D1	Q86TI0	514	543	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60949
TBC1D1	Q86TI0	683	745	695	695	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60949
TBC1D1	Q86TI0	683	745	685	685	Natural variant	ID=VAR_028092;Note=Y->S;Dbxref=dbSNP:rs7677030
TBC1D1	Q86TI0	683	745	730	730	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D1	Q86TI0	1044	1102	1095	1095	Sequence conflict	Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D1	Q86TI0	745	799	751	757	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYE
TBC1D1	Q86TI0	745	799	768	778	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYE
TBC1D1	Q86TI0	745	799	783	785	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYE
TBC1D1	Q86TI0	745	799	790	798	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYE
TBC1D1	Q86TI0	1044	1102	1035	1047	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYE
TBC1D1	Q86TI0	1044	1102	1051	1065	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QYE
RPS7	P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
RPS7	P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
RPS7	P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
RSF1	Q96T23	1187	1250	1	1441	Chain	ID=PRO_0000059326;Note=Remodeling and spacing factor 1
RSF1	Q96T23	905	940	1	1441	Chain	ID=PRO_0000059326;Note=Remodeling and spacing factor 1
RSF1	Q96T23	93	124	1	1441	Chain	ID=PRO_0000059326;Note=Remodeling and spacing factor 1
RSF1	Q96T23	905	940	891	941	Zinc finger	Note=PHD-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
RSF1	Q96T23	1187	1250	1146	1243	Compositional bias	Note=Arg-rich
RSF1	Q96T23	1187	1250	1221	1221	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
RSF1	Q96T23	1187	1250	1223	1223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
RSF1	Q96T23	1187	1250	1226	1226	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
RSF1	Q96T23	93	124	1	252	Alternative sequence	ID=VSP_012499;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11788598,ECO:0000303|PubMed:11944984;Dbxref=PMID:11788598,PMID:11944984
RSF1	Q96T23	93	124	93	123	Alternative sequence	ID=VSP_012500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11944984;Dbxref=PMID:11944984
TBC1D12	O60347	506	533	1	775	Chain	ID=PRO_0000208037;Note=TBC1 domain family member 12
TBC1D12	O60347	563	587	1	775	Chain	ID=PRO_0000208037;Note=TBC1 domain family member 12
TBC1D12	O60347	587	630	1	775	Chain	ID=PRO_0000208037;Note=TBC1 domain family member 12
TBC1D12	O60347	506	533	484	692	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D12	O60347	563	587	484	692	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D12	O60347	587	630	484	692	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D19	Q8N5T2	160	197	1	526	Chain	ID=PRO_0000208047;Note=TBC1 domain family member 19
TBC1D19	Q8N5T2	297	318	1	526	Chain	ID=PRO_0000208047;Note=TBC1 domain family member 19
TBC1D19	Q8N5T2	361	372	1	526	Chain	ID=PRO_0000208047;Note=TBC1 domain family member 19
TBC1D19	Q8N5T2	297	318	251	472	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D19	Q8N5T2	361	372	251	472	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D19	Q8N5T2	160	197	176	176	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D20	Q96BZ9	85	112	1	403	Chain	ID=PRO_0000208048;Note=TBC1 domain family member 20
TBC1D20	Q96BZ9	23	85	1	403	Chain	ID=PRO_0000208048;Note=TBC1 domain family member 20
TBC1D20	Q96BZ9	85	112	60	246	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D20	Q96BZ9	23	85	60	246	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D20	Q96BZ9	85	112	105	105	Site	Note=Arginine finger
TBC1D20	Q96BZ9	85	112	1	192	Alternative sequence	ID=VSP_008100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D20	Q96BZ9	23	85	1	192	Alternative sequence	ID=VSP_008100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D20	Q96BZ9	23	85	79	79	Natural variant	ID=VAR_052543;Note=N->S;Dbxref=dbSNP:rs36088178
TBC1D20	Q96BZ9	85	112	105	105	Mutagenesis	Note=1000-fold decrease in GAP activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23236136;Dbxref=PMID:23236136
TBC1D20	Q96BZ9	23	85	26	40	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	23	85	42	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	23	85	47	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	23	85	57	60	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HLQ
TBC1D20	Q96BZ9	23	85	63	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	85	112	89	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	85	112	96	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	85	112	105	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HL4
TBC1D20	Q96BZ9	85	112	112	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HLQ
SNRPB	P14678	89	140	1	240	Chain	ID=PRO_0000125517;Note=Small nuclear ribonucleoprotein-associated proteins B and B'
SNRPB	P14678	89	140	108	108	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SNRPB	P14678	89	140	108	108	Modified residue	Note=Dimethylated arginine%3B in A2780 ovarian carcinoma cell line;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10
SNRPB	P14678	89	140	108	108	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SNRPB	P14678	89	140	112	112	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SNRPB	P14678	89	140	112	112	Modified residue	Note=Dimethylated arginine%3B in A2780 ovarian carcinoma cell line;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10
SNRPB	P14678	89	140	112	112	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
TBC1D14	Q9P2M4	423	450	1	693	Chain	ID=PRO_0000208040;Note=TBC1 domain family member 14
TBC1D14	Q9P2M4	482	506	1	693	Chain	ID=PRO_0000208040;Note=TBC1 domain family member 14
TBC1D14	Q9P2M4	423	450	1	693	Chain	ID=PRO_0000208040;Note=TBC1 domain family member 14
TBC1D14	Q9P2M4	482	506	1	693	Chain	ID=PRO_0000208040;Note=TBC1 domain family member 14
TBC1D14	Q9P2M4	423	450	401	611	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D14	Q9P2M4	482	506	401	611	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D14	Q9P2M4	423	450	401	611	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D14	Q9P2M4	482	506	401	611	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D14	Q9P2M4	423	450	446	446	Natural variant	ID=VAR_059856;Note=E->Q;Dbxref=dbSNP:rs11731231
TBC1D14	Q9P2M4	423	450	446	446	Natural variant	ID=VAR_059856;Note=E->Q;Dbxref=dbSNP:rs11731231
TBC1D14	Q9P2M4	423	450	423	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QQ8
TBC1D14	Q9P2M4	423	450	423	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QQ8
TBC1D14	Q9P2M4	482	506	487	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QQ8
TBC1D14	Q9P2M4	482	506	487	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QQ8
TBC1D14	Q9P2M4	482	506	502	504	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QQ8
TBC1D14	Q9P2M4	482	506	502	504	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QQ8
TBC1D16	Q8TBP0	576	636	1	767	Chain	ID=PRO_0000208044;Note=TBC1 domain family member 16
TBC1D16	Q8TBP0	469	513	1	767	Chain	ID=PRO_0000208044;Note=TBC1 domain family member 16
TBC1D16	Q8TBP0	576	636	425	635	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D16	Q8TBP0	469	513	425	635	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D16	Q8TBP0	469	513	476	476	Natural variant	ID=VAR_052542;Note=E->K;Dbxref=dbSNP:rs34845477
TBC1D31	Q96DN5	344	403	1	1066	Chain	ID=PRO_0000051420;Note=TBC1 domain family member 31
TBC1D31	Q96DN5	802	833	1	1066	Chain	ID=PRO_0000051420;Note=TBC1 domain family member 31
TBC1D31	Q96DN5	880	945	1	1066	Chain	ID=PRO_0000051420;Note=TBC1 domain family member 31
TBC1D31	Q96DN5	991	1022	1	1066	Chain	ID=PRO_0000051420;Note=TBC1 domain family member 31
TBC1D31	Q96DN5	802	833	728	861	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TBC1D31	Q96DN5	880	945	914	948	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TBC1D31	Q96DN5	802	833	802	832	Alternative sequence	ID=VSP_043414;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TBC1D31	Q96DN5	880	945	880	944	Alternative sequence	ID=VSP_016184;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TBC1D31	Q96DN5	344	403	358	358	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TBC1D5	Q92609	234	250	1	795	Chain	ID=PRO_0000208028;Note=TBC1 domain family member 5
TBC1D5	Q92609	234	250	1	795	Chain	ID=PRO_0000208028;Note=TBC1 domain family member 5
TBC1D5	Q92609	234	250	81	359	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBC1D5	Q92609	234	250	81	359	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
TBL1XR1	Q9BZK7	349	374	2	514	Chain	ID=PRO_0000051266;Note=F-box-like/WD repeat-containing protein TBL1XR1
TBL1XR1	Q9BZK7	349	374	2	514	Chain	ID=PRO_0000051266;Note=F-box-like/WD repeat-containing protein TBL1XR1
TBL1XR1	Q9BZK7	349	374	347	386	Repeat	Note=WD 5
TBL1XR1	Q9BZK7	349	374	347	386	Repeat	Note=WD 5
TBL1XR1	Q9BZK7	349	374	352	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG9
TBL1XR1	Q9BZK7	349	374	352	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG9
TBL1XR1	Q9BZK7	349	374	361	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG9
TBL1XR1	Q9BZK7	349	374	361	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG9
TBL1XR1	Q9BZK7	349	374	371	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG9
TBL1XR1	Q9BZK7	349	374	371	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG9
THUMPD3	Q9BV44	84	110	1	507	Chain	ID=PRO_0000259769;Note=THUMP domain-containing protein 3
THUMPD3	Q9BV44	84	110	1	507	Chain	ID=PRO_0000259769;Note=THUMP domain-containing protein 3
THUMPD3	Q9BV44	84	110	1	507	Chain	ID=PRO_0000259769;Note=THUMP domain-containing protein 3
TOMM40L	Q969M1	61	92	1	308	Chain	ID=PRO_0000051536;Note=Mitochondrial import receptor subunit TOM40B
TOMM40L	Q969M1	92	126	1	308	Chain	ID=PRO_0000051536;Note=Mitochondrial import receptor subunit TOM40B
TOMM40L	Q969M1	61	92	1	308	Chain	ID=PRO_0000051536;Note=Mitochondrial import receptor subunit TOM40B
TOMM40L	Q969M1	92	126	1	308	Chain	ID=PRO_0000051536;Note=Mitochondrial import receptor subunit TOM40B
TOMM40L	Q969M1	92	126	93	126	Alternative sequence	ID=VSP_054885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOMM40L	Q969M1	92	126	93	126	Alternative sequence	ID=VSP_054885;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TOMM40L	Q969M1	92	126	100	100	Natural variant	ID=VAR_035815;Note=In a colorectal cancer sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TOMM40L	Q969M1	92	126	100	100	Natural variant	ID=VAR_035815;Note=In a colorectal cancer sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
TMC7	Q7Z402	153	209	1	723	Chain	ID=PRO_0000287165;Note=Transmembrane channel-like protein 7
TMC7	Q7Z402	335	393	1	723	Chain	ID=PRO_0000287165;Note=Transmembrane channel-like protein 7
TMC7	Q7Z402	624	675	1	723	Chain	ID=PRO_0000287165;Note=Transmembrane channel-like protein 7
TMC7	Q7Z402	153	209	1	168	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	153	209	169	189	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	153	209	190	219	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	335	393	285	362	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	335	393	363	383	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	335	393	384	404	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	624	675	623	665	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	624	675	666	686	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	624	675	638	638	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMC7	Q7Z402	335	393	355	355	Natural variant	ID=VAR_061852;Note=T->S;Dbxref=dbSNP:rs55796412
TMC7	Q7Z402	624	675	635	635	Natural variant	ID=VAR_032280;Note=T->I;Dbxref=dbSNP:rs11864159
TMCO1	Q9UM00	49	69	1	188	Chain	ID=PRO_0000244076;Note=Calcium load-activated calcium channel
TMCO1	Q9UM00	49	69	31	90	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27212239;Dbxref=PMID:27212239
TMCO1	Q9UM00	49	69	32	89	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TMCO1	Q9UM00	49	69	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TMCO1	Q9UM00	49	69	64	82	Alternative sequence	ID=VSP_019505;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
TMCO1	Q9UM00	49	69	47	188	Natural variant	ID=VAR_076652;Note=In CFSMR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20018682;Dbxref=PMID:20018682
TMCO3	Q6UWJ1	208	272	23	677	Chain	ID=PRO_0000249856;Note=Transmembrane and coiled-coil domain-containing protein 3
TMCO3	Q6UWJ1	315	346	23	677	Chain	ID=PRO_0000249856;Note=Transmembrane and coiled-coil domain-containing protein 3
TMCO3	Q6UWJ1	315	346	317	337	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMCO3	Q6UWJ1	208	272	221	224	Compositional bias	Note=Poly-Glu
TMCO3	Q6UWJ1	208	272	230	230	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMCO3	Q6UWJ1	208	272	223	223	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMCO4	Q5TGY1	252	292	1	634	Chain	ID=PRO_0000305149;Note=Transmembrane and coiled-coil domain-containing protein 4
TMCO4	Q5TGY1	252	292	254	293	Alternative sequence	ID=VSP_028242;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
TMCO6	Q96DC7	166	201	1	493	Chain	ID=PRO_0000305157;Note=Transmembrane and coiled-coil domain-containing protein 6
TMCO6	Q96DC7	400	456	1	493	Chain	ID=PRO_0000305157;Note=Transmembrane and coiled-coil domain-containing protein 6
TMCO6	Q96DC7	400	456	386	406	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMCO6	Q96DC7	400	456	442	442	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMPRSS11E	Q9UL52	163	176	1	191	Chain	ID=PRO_0000027891;Note=Transmembrane protease serine 11E non-catalytic chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS11E	Q9UL52	163	176	41	423	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMPRSS11E	Q9UL52	163	176	49	167	Domain	Note=SEA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00188
TMPRSS11E	Q9UL52	163	176	166	166	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM128	Q5BJH2	80	132	1	165	Chain	ID=PRO_0000254556;Note=Transmembrane protein 128
TMEM128	Q5BJH2	80	132	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM128	Q5BJH2	80	132	119	139	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFAIP2	Q03169	400	432	1	654	Chain	ID=PRO_0000118932;Note=Tumor necrosis factor alpha-induced protein 2
TNFAIP2	Q03169	515	567	1	654	Chain	ID=PRO_0000118932;Note=Tumor necrosis factor alpha-induced protein 2
TNFAIP2	Q03169	400	432	1	654	Chain	ID=PRO_0000118932;Note=Tumor necrosis factor alpha-induced protein 2
TNFAIP2	Q03169	515	567	1	654	Chain	ID=PRO_0000118932;Note=Tumor necrosis factor alpha-induced protein 2
TNFAIP2	Q03169	515	567	565	565	Natural variant	ID=VAR_020773;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2229727
TNFAIP2	Q03169	515	567	565	565	Natural variant	ID=VAR_020773;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs2229727
TMEM131	Q92545	1524	1574	1	1883	Chain	ID=PRO_0000097538;Note=Transmembrane protein 131
TMEM131	Q92545	1067	1128	1	1883	Chain	ID=PRO_0000097538;Note=Transmembrane protein 131
TMEM131	Q92545	161	200	1	1883	Chain	ID=PRO_0000097538;Note=Transmembrane protein 131
TMEM131	Q92545	1067	1128	1091	1111	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM131	Q92545	1067	1128	1118	1138	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM134	Q9H6X4	150	168	1	195	Chain	ID=PRO_0000279485;Note=Transmembrane protein 134
TMEM134	Q9H6X4	135	150	1	195	Chain	ID=PRO_0000279485;Note=Transmembrane protein 134
TMEM134	Q9H6X4	135	150	123	143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM134	Q9H6X4	150	168	144	154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM134	Q9H6X4	135	150	144	154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM134	Q9H6X4	150	168	155	175	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM134	Q9H6X4	150	168	136	150	Alternative sequence	ID=VSP_023452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM134	Q9H6X4	135	150	136	150	Alternative sequence	ID=VSP_023452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM134	Q9H6X4	135	150	136	136	Alternative sequence	ID=VSP_023453;Note=In isoform 3. V->GPAQCLALETELGELPGEGLCLGHLQLRWWVSRAGGGSPRPHHCSCPHPRGSVCVQC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM134	Q9H6X4	150	168	137	195	Alternative sequence	ID=VSP_023454;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM134	Q9H6X4	135	150	137	195	Alternative sequence	ID=VSP_023454;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNRC18	O15417	2796	2875	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	2287	2342	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	1731	1823	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	1511	1553	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	1076	1406	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	820	869	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	114	162	1	2968	Chain	ID=PRO_0000299142;Note=Trinucleotide repeat-containing gene 18 protein
TNRC18	O15417	2796	2875	2817	2962	Domain	Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
TNRC18	O15417	1511	1553	1481	1516	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC18	O15417	1076	1406	968	1192	Compositional bias	Note=Pro-rich
TNRC18	O15417	1076	1406	1127	1127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TNRC18	O15417	1076	1406	1136	1136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TNRC18	O15417	1511	1553	1540	1540	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TNRC18	O15417	820	869	1	1064	Alternative sequence	ID=VSP_033124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	114	162	1	1064	Alternative sequence	ID=VSP_033124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	1076	1406	1403	1490	Alternative sequence	ID=VSP_033128;Note=In isoform 3. QEMGGAERALVARPSLESLLAAGSHMLREVLDGPVVDPLKNLRLPRELKPNKKYSWMRKKEERMYAMKSSLEDMDALELDFRMRLAEV->PPQGLPPCMGQGSPMPAGLPDCARGPAPTLSGWPRLGEQSRVGLQPGVSVKGTRWRGPGTGPPWSKPSHYRKPQWC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	2796	2875	1491	2968	Alternative sequence	ID=VSP_033129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	2287	2342	1491	2968	Alternative sequence	ID=VSP_033129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	1731	1823	1491	2968	Alternative sequence	ID=VSP_033129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	1511	1553	1491	2968	Alternative sequence	ID=VSP_033129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TNRC18	O15417	2796	2875	2257	2968	Alternative sequence	ID=VSP_033127;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
TNRC18	O15417	2287	2342	2257	2968	Alternative sequence	ID=VSP_033127;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
TNRC18	O15417	1076	1406	1193	1193	Natural variant	ID=VAR_042722;Note=A->G;Dbxref=dbSNP:rs12671708
TNRC18	O15417	1076	1406	1255	1255	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNRC18	O15417	1076	1406	1267	1267	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNRC18	O15417	1076	1406	1343	1343	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNRC18	O15417	2287	2342	2292	2292	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNFSF10	P50591	104	139	1	281	Chain	ID=PRO_0000185503;Note=Tumor necrosis factor ligand superfamily member 10
TNFSF10	P50591	104	139	39	281	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFSF10	P50591	104	139	102	281	Alternative sequence	ID=VSP_043508;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:21859711,ECO:0000303|Ref.4;Dbxref=PMID:14702039,PMID:21859711
TNFSF10	P50591	104	139	123	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DG6
TNFSF10	P50591	104	139	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D4V
TNNT2	P45379	93	132	2	298	Chain	ID=PRO_0000186173;Note=Troponin T%2C cardiac muscle
TNNT2	P45379	93	132	99	137	Alternative sequence	ID=VSP_006646;Note=In isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8088824;Dbxref=PMID:8088824
TNNT2	P45379	93	132	102	102	Natural variant	ID=VAR_016195;Note=In CMH2. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8989109;Dbxref=dbSNP:rs121964856,PMID:8989109
TNNT2	P45379	93	132	102	102	Natural variant	ID=VAR_007606;Note=In CMH2. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8205619;Dbxref=dbSNP:rs121964856,PMID:8205619
TNNT2	P45379	93	132	102	102	Natural variant	ID=VAR_016196;Note=In CMH2. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9060892;Dbxref=dbSNP:rs397516456,PMID:9060892
TNNT2	P45379	93	132	104	104	Natural variant	ID=VAR_009194;Note=In CMH2. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10525521;Dbxref=dbSNP:rs397516457,PMID:10525521
TNNT2	P45379	93	132	114	114	Natural variant	ID=VAR_016197;Note=In CMH2. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9140840;Dbxref=dbSNP:rs727504245,PMID:9140840
TNNT2	P45379	93	132	120	120	Natural variant	ID=VAR_007607;Note=In CMH2. F->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7898523,ECO:0000269|PubMed:9482583;Dbxref=dbSNP:rs121964858,PMID:7898523,PMID:9482583
TNNT2	P45379	93	132	120	120	Natural variant	ID=VAR_019878;Note=In CMH2. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12707239;Dbxref=dbSNP:rs121964858,PMID:12707239
TNFRSF18	Q9Y5U5	62	103	26	241	Chain	ID=PRO_0000034595;Note=Tumor necrosis factor receptor superfamily member 18
TNFRSF18	Q9Y5U5	62	103	26	162	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF18	Q9Y5U5	62	103	34	72	Repeat	Note=TNFR-Cys 1
TNFRSF18	Q9Y5U5	62	103	74	112	Repeat	Note=TNFR-Cys 2
TNFRSF18	Q9Y5U5	62	103	74	86	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF18	Q9Y5U5	62	103	81	94	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TNFRSF18	Q9Y5U5	62	103	64	64	Natural variant	ID=VAR_052355;Note=E->K;Dbxref=dbSNP:rs11466687
TNFRSF18	Q9Y5U5	62	103	83	83	Natural variant	ID=VAR_052356;Note=D->N;Dbxref=dbSNP:rs11466688
LTBR	P36941	106	157	31	435	Chain	ID=PRO_0000034552;Note=Tumor necrosis factor receptor superfamily member 3
LTBR	P36941	222	258	31	435	Chain	ID=PRO_0000034552;Note=Tumor necrosis factor receptor superfamily member 3
LTBR	P36941	106	157	31	227	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBR	P36941	222	258	31	227	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBR	P36941	222	258	228	248	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBR	P36941	222	258	249	435	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
LTBR	P36941	106	157	82	124	Repeat	Note=TNFR-Cys 2
LTBR	P36941	106	157	125	168	Repeat	Note=TNFR-Cys 3
LTBR	P36941	106	157	101	116	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
LTBR	P36941	106	157	104	124	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
LTBR	P36941	106	157	126	132	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
LTBR	P36941	106	157	139	148	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
LTBR	P36941	106	157	142	167	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
TNFRSF4	P43489	211	254	29	277	Chain	ID=PRO_0000034554;Note=Tumor necrosis factor receptor superfamily member 4
TNFRSF4	P43489	211	254	29	214	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF4	P43489	211	254	215	235	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNFRSF4	P43489	211	254	236	277	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC6B	Q9UPQ9	152	935	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	994	1019	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	1170	1202	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	1309	1368	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	152	935	1	994	Region	Note=Interaction with argonaute proteins
TNRC6B	Q9UPQ9	994	1019	1	994	Region	Note=Interaction with argonaute proteins
TNRC6B	Q9UPQ9	1309	1368	1218	1723	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6B	Q9UPQ9	152	935	825	880	Compositional bias	Note=Pro-rich
TNRC6B	Q9UPQ9	1170	1202	1150	1220	Compositional bias	Note=Gln-rich
TNRC6B	Q9UPQ9	152	935	879	879	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:23186163,PMID:24275569
TNRC6B	Q9UPQ9	152	935	153	935	Alternative sequence	ID=VSP_037291;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNRC6B	Q9UPQ9	1170	1202	1138	1194	Alternative sequence	ID=VSP_037293;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
TNRC6B	Q9UPQ9	152	935	517	517	Natural variant	ID=VAR_051452;Note=S->C;Dbxref=dbSNP:rs17001767
TNRC6B	Q9UPQ9	1309	1368	1321	1321	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNRC6C	Q9HCJ0	926	953	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1020	1070	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1070	1119	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1119	1159	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1267	1323	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1323	1387	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1435	1500	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	926	953	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1020	1070	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1070	1119	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1119	1159	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1267	1323	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1323	1387	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1435	1500	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	926	953	933	978	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TNRC6C	Q9HCJ0	926	953	933	978	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TNRC6C	Q9HCJ0	926	953	1	926	Region	Note=Sufficient for interaction with argonaute family proteins
TNRC6C	Q9HCJ0	926	953	1	926	Region	Note=Sufficient for interaction with argonaute family proteins
TNRC6C	Q9HCJ0	1267	1323	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1323	1387	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1435	1500	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1267	1323	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1323	1387	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1435	1500	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1323	1387	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1435	1500	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1323	1387	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1435	1500	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1323	1387	1371	1417	Region	Note=Required for interaction with PABPC1
TNRC6C	Q9HCJ0	1323	1387	1371	1417	Region	Note=Required for interaction with PABPC1
TNRC6C	Q9HCJ0	1323	1387	1381	1399	Region	Note=PABPC1-interacting motif-2 (PAM2)
TNRC6C	Q9HCJ0	1323	1387	1381	1399	Region	Note=PABPC1-interacting motif-2 (PAM2)
TNRC6C	Q9HCJ0	1119	1159	1156	1214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC6C	Q9HCJ0	1119	1159	1156	1214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC6C	Q9HCJ0	1435	1500	1435	1435	Alternative sequence	ID=VSP_023322;Note=In isoform 2. G->GGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TNRC6C	Q9HCJ0	1435	1500	1435	1435	Alternative sequence	ID=VSP_023322;Note=In isoform 2. G->GGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TNRC6C	Q9HCJ0	1267	1323	1294	1300	Mutagenesis	Note=Abolishes association with CCR4-NOT complex. QSRLPQW->AAAAPAA
TNRC6C	Q9HCJ0	1267	1323	1294	1300	Mutagenesis	Note=Abolishes association with CCR4-NOT complex. QSRLPQW->AAAAPAA
TNRC6C	Q9HCJ0	1435	1500	1445	1445	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1487%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1445	1445	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1487%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1487	1487	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1487	1487	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1494	1494	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1487%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1494	1494	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1487%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	926	953	936	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKL
TNRC6C	Q9HCJ0	926	953	936	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKL
TPM2	P07951	213	234	1	284	Chain	ID=PRO_0000205627;Note=Tropomyosin beta chain
TPM2	P07951	38	80	1	284	Chain	ID=PRO_0000205627;Note=Tropomyosin beta chain
TPM2	P07951	213	234	1	284	Coiled coil	Ontology_term=ECO:0000250;evidence=ECO:0000250
TPM2	P07951	38	80	1	284	Coiled coil	Ontology_term=ECO:0000250;evidence=ECO:0000250
TPM2	P07951	38	80	53	53	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=PMID:24692096
TPM2	P07951	38	80	61	61	Modified residue	Note=Phosphoserine%3B by PIK3CG;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58774
TPM2	P07951	38	80	79	79	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=PMID:24692096
TPM2	P07951	213	234	215	215	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58775
TPM2	P07951	38	80	1	80	Alternative sequence	ID=VSP_006594;Note=In isoform 3. MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD->MAGISSIDAVKKKIQSLQQVADEAEERAEHLQREADAERQARER;Ontology_term=ECO:0000305;evidence=ECO:0000305
TPM2	P07951	213	234	189	213	Alternative sequence	ID=VSP_006595;Note=In isoform 2 and isoform 3. KCGDLEEELKIVTNNLKSLEAQADK->RARQLEEELRTMDQALKSLMASEEE;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2059197,ECO:0000303|PubMed:3865200,ECO:0000303|Ref.4;Dbxref=PMID:15489334,PMID:2059197,PMID:3865200
TPM2	P07951	38	80	41	41	Natural variant	ID=VAR_070978;Note=In NEM4%3B also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17846275,ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs137853306,PMID:17846275,PMID:24692096
TPM2	P07951	38	80	49	49	Natural variant	ID=VAR_070979;Note=In CAPM2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19047562;Dbxref=PMID:19047562
TPM2	P07951	38	80	52	52	Natural variant	ID=VAR_070980;Note=In CAPM2. G->GG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19047562;Dbxref=PMID:19047562
TPM2	P07951	213	234	218	218	Natural variant	ID=VAR_071497;Note=Probable disease-associated mutation in patients with undefined congenital myopathy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=PMID:24692096
TPRA1	Q86W33	166	203	1	373	Chain	ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1
TPRA1	Q86W33	86	115	1	373	Chain	ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1
TPRA1	Q86W33	166	203	1	373	Chain	ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1
TPRA1	Q86W33	86	115	1	373	Chain	ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1
TPRA1	Q86W33	166	203	1	373	Chain	ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1
TPRA1	Q86W33	86	115	1	373	Chain	ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1
TPRA1	Q86W33	86	115	76	96	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	86	115	76	96	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	86	115	76	96	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	166	203	151	171	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	166	203	151	171	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	166	203	151	171	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	166	203	192	212	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	166	203	192	212	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPRA1	Q86W33	166	203	192	212	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPST1	O60507	348	365	1	370	Chain	ID=PRO_0000189826;Note=Protein-tyrosine sulfotransferase 1
TPST1	O60507	348	365	26	370	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRIM3	O75382	511	567	2	744	Chain	ID=PRO_0000056197;Note=Tripartite motif-containing protein 3
TRIM3	O75382	511	567	2	744	Chain	ID=PRO_0000056197;Note=Tripartite motif-containing protein 3
TRIM3	O75382	511	567	2	744	Chain	ID=PRO_0000056197;Note=Tripartite motif-containing protein 3
TRIM3	O75382	511	567	473	516	Repeat	Note=NHL 1
TRIM3	O75382	511	567	473	516	Repeat	Note=NHL 1
TRIM3	O75382	511	567	473	516	Repeat	Note=NHL 1
TRIM3	O75382	511	567	520	563	Repeat	Note=NHL 2
TRIM3	O75382	511	567	520	563	Repeat	Note=NHL 2
TRIM3	O75382	511	567	520	563	Repeat	Note=NHL 2
TRIM3	O75382	511	567	564	605	Repeat	Note=NHL 3
TRIM3	O75382	511	567	564	605	Repeat	Note=NHL 3
TRIM3	O75382	511	567	564	605	Repeat	Note=NHL 3
TROAP	Q12815	297	340	1	778	Chain	ID=PRO_0000065636;Note=Tastin
TROAP	Q12815	388	433	1	778	Chain	ID=PRO_0000065636;Note=Tastin
TROAP	Q12815	297	340	324	324	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TROAP	Q12815	297	340	334	334	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:23186163
TROAP	Q12815	297	340	113	778	Alternative sequence	ID=VSP_055063;Note=In isoform 3. EAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLTAIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP->GAMACTCNHSYSGG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TROAP	Q12815	388	433	113	778	Alternative sequence	ID=VSP_055063;Note=In isoform 3. EAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLTAIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP->GAMACTCNHSYSGG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TROAP	Q12815	297	340	145	778	Alternative sequence	ID=VSP_042821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TROAP	Q12815	388	433	145	778	Alternative sequence	ID=VSP_042821;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TIE1	P35590	213	257	22	1138	Chain	ID=PRO_0000024471;Note=Tyrosine-protein kinase receptor Tie-1
TIE1	P35590	304	347	22	1138	Chain	ID=PRO_0000024471;Note=Tyrosine-protein kinase receptor Tie-1
TIE1	P35590	213	257	22	759	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIE1	P35590	304	347	22	759	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIE1	P35590	213	257	214	256	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	304	347	305	345	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	213	257	228	237	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	213	257	231	244	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	213	257	246	255	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	304	347	315	327	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	304	347	321	333	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	304	347	335	344	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIE1	P35590	304	347	305	317	Alternative sequence	ID=VSP_047607;Note=In isoform 3. ACAPGHFGADCRL->VHQGHCGAREDHS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
TIE1	P35590	304	347	318	1138	Alternative sequence	ID=VSP_047608;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
TIPIN	Q9BVW5	158	227	1	301	Chain	ID=PRO_0000305253;Note=TIMELESS-interacting protein
TIPIN	Q9BVW5	158	227	194	194	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TIPIN	Q9BVW5	158	227	222	222	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TIPIN	Q9BVW5	158	227	201	201	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLE1	Q04724	99	124	1	770	Chain	ID=PRO_0000051276;Note=Transducin-like enhancer protein 1
TLE1	Q04724	78	99	1	770	Chain	ID=PRO_0000051276;Note=Transducin-like enhancer protein 1
TLE1	Q04724	63	78	1	770	Chain	ID=PRO_0000051276;Note=Transducin-like enhancer protein 1
TLE1	Q04724	99	124	1	131	Region	Note=Q domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21429299;Dbxref=PMID:21429299
TLE1	Q04724	78	99	1	131	Region	Note=Q domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21429299;Dbxref=PMID:21429299
TLE1	Q04724	63	78	1	131	Region	Note=Q domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21429299;Dbxref=PMID:21429299
TLE1	Q04724	78	99	22	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OM3
TLE1	Q04724	63	78	22	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OM3
TLE1	Q04724	78	99	93	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OM3
TLE1	Q04724	99	124	98	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OM3
TLE1	Q04724	78	99	98	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OM3
TLE1	Q04724	99	124	116	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OM3
TMEM39B	Q9GZU3	117	145	1	492	Chain	ID=PRO_0000279232;Note=Transmembrane protein 39B
TMEM39B	Q9GZU3	117	145	115	135	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM39B	Q9GZU3	117	145	1	199	Alternative sequence	ID=VSP_056123;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM39B	Q9GZU3	117	145	1	117	Alternative sequence	ID=VSP_056124;Note=In isoform 3. MGGRRGPNRTSYCRNPLCEPGSSGGSSGSHTSSASVTSVRSRTRSSSGTGLSSPPLATQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHPPSHTSL->MK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM260	Q9NX78	212	272	1	707	Chain	ID=PRO_0000089905;Note=Transmembrane protein 260
TMEM260	Q9NX78	575	592	1	707	Chain	ID=PRO_0000089905;Note=Transmembrane protein 260
TMEM260	Q9NX78	212	272	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM260	Q9NX78	575	592	287	707	Alternative sequence	ID=VSP_008621;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TMEM260	Q9NX78	575	592	410	707	Alternative sequence	ID=VSP_058994;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15489334;Dbxref=PMID:15489334
TMEM260	Q9NX78	212	272	245	245	Natural variant	ID=VAR_057823;Note=A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17776256,PMID:15489334
TMEM260	Q9NX78	575	592	465	707	Natural variant	ID=VAR_078766;Note=In SHDRA%3B reduced expression of isoform 1 due to nonsense-mediated decay in patient-derived cells. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28318500;Dbxref=PMID:28318500
TOP2B	Q02880	1496	1538	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	1459	1496	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	1197	1262	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	1117	1169	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	954	1021	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	672	703	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	376	422	2	1626	Chain	ID=PRO_0000145369;Note=DNA topoisomerase 2-beta
TOP2B	Q02880	376	422	397	399	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TOP2B	Q02880	954	1021	1011	1020	Region	Note=Interaction with DNA
TOP2B	Q02880	672	703	682	682	Site	Note=Interaction with DNA
TOP2B	Q02880	672	703	683	683	Site	Note=Interaction with DNA
TOP2B	Q02880	1197	1262	1236	1236	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163
TOP2B	Q02880	1459	1496	1461	1461	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TOP2B	Q02880	1459	1496	1466	1466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
TOP2B	Q02880	1459	1496	1473	1473	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TOP2B	Q02880	1459	1496	1476	1476	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
TOP2B	Q02880	1496	1538	1522	1522	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TOP2B	Q02880	1496	1538	1524	1524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TOP2B	Q02880	1496	1538	1526	1526	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TOP2B	Q02880	672	703	676	676	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TOP2B	Q02880	1197	1262	1214	1214	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TOP2B	Q02880	1197	1262	1217	1217	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TOP2B	Q02880	1197	1262	1226	1226	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TOP2B	Q02880	1197	1262	1227	1227	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
TOP2B	Q02880	1197	1262	1250	1250	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
TOP2B	Q02880	1197	1262	1262	1262	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TOP2B	Q02880	1459	1496	1490	1490	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TOP2B	Q02880	672	703	664	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	672	703	676	678	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	672	703	679	698	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	953	959	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	961	966	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	969	971	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	976	980	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	989	992	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	995	1004	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	1006	1009	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	1013	1017	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	954	1021	1021	1024	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	1117	1169	1144	1147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	1117	1169	1151	1154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	1117	1169	1156	1177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TOP2B	Q02880	1197	1262	1181	1205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QX3
TSC1	Q92574	938	991	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	834	875	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	444	479	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	70	121	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	938	991	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	834	875	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	444	479	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	70	121	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	938	991	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	834	875	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	938	991	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	834	875	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	70	121	70	120	Alternative sequence	ID=VSP_042890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSC1	Q92574	70	121	70	120	Alternative sequence	ID=VSP_042890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSC1	Q92574	70	121	72	72	Natural variant	ID=VAR_054387;Note=In TSC1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10533069;Dbxref=dbSNP:rs118203354,PMID:10533069
TSC1	Q92574	70	121	72	72	Natural variant	ID=VAR_054387;Note=In TSC1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10533069;Dbxref=dbSNP:rs118203354,PMID:10533069
TSC1	Q92574	70	121	117	117	Natural variant	ID=VAR_070637;Note=In TSC1%3B reduced expression%3B altered subcellular localization%3B reduced interaction with TSC2%3B reduced inhibition of TORC1 signaling. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18830229,ECO:0000269|PubMed:22161988,ECO:0000269|PubMed:29127155;Dbxref=dbSNP:rs118203368,PMID:18830229,PMID:22161988,PMID:29127155
TSC1	Q92574	70	121	117	117	Natural variant	ID=VAR_070637;Note=In TSC1%3B reduced expression%3B altered subcellular localization%3B reduced interaction with TSC2%3B reduced inhibition of TORC1 signaling. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18830229,ECO:0000269|PubMed:22161988,ECO:0000269|PubMed:29127155;Dbxref=dbSNP:rs118203368,PMID:18830229,PMID:22161988,PMID:29127155
TSC1	Q92574	938	991	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	834	875	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	444	479	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	938	991	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	834	875	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	444	479	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	444	479	448	448	Natural variant	ID=VAR_070651;Note=Rare polymorphism%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs118203518,PMID:22161988
TSC1	Q92574	444	479	448	448	Natural variant	ID=VAR_070651;Note=Rare polymorphism%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs118203518,PMID:22161988
TSC1	Q92574	938	991	978	978	Natural variant	ID=VAR_070661;Note=In TSC1%3B unknown pathological significance%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs397514859,PMID:22161988
TSC1	Q92574	938	991	978	978	Natural variant	ID=VAR_070661;Note=In TSC1%3B unknown pathological significance%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs397514859,PMID:22161988
TSC1	Q92574	938	991	941	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSC1	Q92574	938	991	941	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSC1	Q92574	938	991	975	991	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSC1	Q92574	938	991	975	991	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSPAN5	P62079	150	192	1	268	Chain	ID=PRO_0000219243;Note=Tetraspanin-5
TSPAN5	P62079	44	93	1	268	Chain	ID=PRO_0000219243;Note=Tetraspanin-5
TSPAN5	P62079	27	44	1	268	Chain	ID=PRO_0000219243;Note=Tetraspanin-5
TSPAN5	P62079	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	150	192	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	44	93	49	49	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	150	192	169	169	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	150	192	174	174	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN5	P62079	44	93	91	94	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTC14	Q96N46	234	285	1	770	Chain	ID=PRO_0000106399;Note=Tetratricopeptide repeat protein 14
TTC14	Q96N46	234	285	210	243	Repeat	Note=TPR 1
TTC19	Q6DKK2	104	141	71	380	Chain	ID=PRO_0000106407;Note=Tetratricopeptide repeat protein 19%2C mitochondrial
TTC19	Q6DKK2	141	154	71	380	Chain	ID=PRO_0000106407;Note=Tetratricopeptide repeat protein 19%2C mitochondrial
TTC19	Q6DKK2	154	173	71	380	Chain	ID=PRO_0000106407;Note=Tetratricopeptide repeat protein 19%2C mitochondrial
TTC19	Q6DKK2	104	141	136	169	Repeat	Note=TPR 1
TTC19	Q6DKK2	141	154	136	169	Repeat	Note=TPR 1
TTC19	Q6DKK2	154	173	136	169	Repeat	Note=TPR 1
TSPAN14	Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
TSPAN14	Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN14	Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26668317;Dbxref=PMID:26668317
TSPAN14	Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN14	Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TSPAN14	Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TSPAN14	Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TSPAN14	Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TSPAN14	Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TSPAN14	Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TSPAN14	Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN14	Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSPAN16	Q9UKR8	89	114	1	245	Chain	ID=PRO_0000219264;Note=Tetraspanin-16
TSPAN16	Q9UKR8	89	114	81	94	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN16	Q9UKR8	89	114	95	115	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN16	Q9UKR8	89	114	90	114	Alternative sequence	ID=VSP_056723;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTC39B	Q5VTQ0	310	332	1	682	Chain	ID=PRO_0000292000;Note=Tetratricopeptide repeat protein 39B
TTC39B	Q5VTQ0	124	160	1	682	Chain	ID=PRO_0000292000;Note=Tetratricopeptide repeat protein 39B
TTC39B	Q5VTQ0	92	123	1	682	Chain	ID=PRO_0000292000;Note=Tetratricopeptide repeat protein 39B
TTC39B	Q5VTQ0	310	332	1	483	Alternative sequence	ID=VSP_042798;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTC39B	Q5VTQ0	124	160	1	483	Alternative sequence	ID=VSP_042798;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTC39B	Q5VTQ0	92	123	1	483	Alternative sequence	ID=VSP_042798;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTC39B	Q5VTQ0	124	160	1	165	Alternative sequence	ID=VSP_042799;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC39B	Q5VTQ0	92	123	1	165	Alternative sequence	ID=VSP_042799;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC39B	Q5VTQ0	92	123	1	97	Alternative sequence	ID=VSP_026355;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTC39B	Q5VTQ0	124	160	92	161	Alternative sequence	ID=VSP_042800;Note=In isoform 6. ISSHSDMATSSLHFASCDTQQAPRQRGASTVSSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPW->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC39B	Q5VTQ0	92	123	92	161	Alternative sequence	ID=VSP_042800;Note=In isoform 6. ISSHSDMATSSLHFASCDTQQAPRQRGASTVSSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPW->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTC39B	Q5VTQ0	124	160	128	128	Natural variant	ID=VAR_054078;Note=T->P;Dbxref=dbSNP:rs10961917
TTC39B	Q5VTQ0	310	332	329	329	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTC39C	Q8N584	359	395	1	583	Chain	ID=PRO_0000274352;Note=Tetratricopeptide repeat protein 39C
TTC39C	Q8N584	541	554	1	583	Chain	ID=PRO_0000274352;Note=Tetratricopeptide repeat protein 39C
TTC39C	Q8N584	359	395	353	386	Repeat	Note=TPR 2
TTC39C	Q8N584	359	395	77	583	Alternative sequence	ID=VSP_046040;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTC39C	Q8N584	541	554	77	583	Alternative sequence	ID=VSP_046040;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TIMD4	Q96H15	253	281	25	378	Chain	ID=PRO_0000042103;Note=T-cell immunoglobulin and mucin domain-containing protein 4
TIMD4	Q96H15	226	253	25	378	Chain	ID=PRO_0000042103;Note=T-cell immunoglobulin and mucin domain-containing protein 4
TIMD4	Q96H15	253	281	25	314	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMD4	Q96H15	226	253	25	314	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMD4	Q96H15	253	281	234	277	Compositional bias	Note=Ser-rich
TIMD4	Q96H15	226	253	234	277	Compositional bias	Note=Ser-rich
TIMD4	Q96H15	253	281	254	281	Alternative sequence	ID=VSP_045474;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TIMD4	Q96H15	226	253	240	240	Natural variant	ID=VAR_049946;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6873053,PMID:14702039,PMID:15489334
TPP1	O14773	295	358	196	563	Chain	ID=PRO_0000027375;Note=Tripeptidyl-peptidase 1
TPP1	O14773	295	358	199	563	Domain	Note=Peptidase S53
TPP1	O14773	295	358	313	313	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19038966,ECO:0000269|PubMed:19038967,ECO:0000269|PubMed:19159218;Dbxref=PMID:19038966,PMID:19038967,PMID:19159218
TPP1	O14773	295	358	339	339	Natural variant	ID=VAR_066886;Note=In CLN2. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990111;Dbxref=dbSNP:rs765380155,PMID:21990111
TPP1	O14773	295	358	343	343	Natural variant	ID=VAR_009607;Note=In CLN2%3B displays no residual enzyme activity%3B altered intracellular trafficking. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10330339,ECO:0000269|PubMed:20340139;Dbxref=dbSNP:rs121908197,PMID:10330339,PMID:20340139
TPP1	O14773	295	358	353	353	Natural variant	ID=VAR_016797;Note=In CLN2. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12376936;Dbxref=dbSNP:rs121908206,PMID:12376936
TPP1	O14773	295	358	295	300	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EE6
TPP1	O14773	295	358	303	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EDY
TPP1	O14773	295	358	319	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EDY
TPP1	O14773	295	358	329	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EDY
TPP1	O14773	295	358	334	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EDY
TPP1	O14773	295	358	353	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EDY
TPP2	P29144	98	130	2	1249	Chain	ID=PRO_0000076422;Note=Tripeptidyl-peptidase 2
TPP2	P29144	98	130	40	509	Domain	Note=Peptidase S8
TPX2	Q9ULW0	35	76	1	747	Chain	ID=PRO_0000065581;Note=Targeting protein for Xklp2
TPX2	Q9ULW0	35	76	59	59	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TPX2	Q9ULW0	35	76	72	72	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TPX2	Q9ULW0	35	76	33	41	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXM
TRPA1	O75762	979	1017	1	1119	Chain	ID=PRO_0000215369;Note=Transient receptor potential cation channel subfamily A member 1
TRPA1	O75762	979	1017	957	1119	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25855297;Dbxref=PMID:25855297
TRPC1	P48995	109	143	1	793	Chain	ID=PRO_0000215303;Note=Short transient receptor potential channel 1
TRPC1	P48995	211	254	1	793	Chain	ID=PRO_0000215303;Note=Short transient receptor potential channel 1
TRPC1	P48995	479	527	1	793	Chain	ID=PRO_0000215303;Note=Short transient receptor potential channel 1
TRPC1	P48995	109	143	1	386	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC1	P48995	211	254	1	386	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC1	P48995	479	527	476	539	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC1	P48995	109	143	83	111	Repeat	Note=ANK 2
TRPC1	P48995	109	143	112	138	Repeat	Note=ANK 3
TRPC1	P48995	109	143	110	143	Alternative sequence	ID=VSP_006560;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7568191,ECO:0000303|PubMed:8663995;Dbxref=PMID:15489334,PMID:7568191,PMID:8663995
TSPAN3	O60637	85	110	1	253	Chain	ID=PRO_0000219239;Note=Tetraspanin-3
TSPAN3	O60637	85	110	72	85	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN3	O60637	85	110	86	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN3	O60637	85	110	107	212	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN3	O60637	85	110	22	85	Alternative sequence	ID=VSP_043519;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSPAN3	O60637	85	110	86	110	Alternative sequence	ID=VSP_042679;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
TSPAN3	O60637	85	110	85	85	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
THBS4	P35443	329	375	27	961	Chain	ID=PRO_0000035852;Note=Thrombospondin-4
THBS4	P35443	484	520	27	961	Chain	ID=PRO_0000035852;Note=Thrombospondin-4
THBS4	P35443	329	375	326	363	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS4	P35443	484	520	463	495	Repeat	Note=TSP type-3 1
THBS4	P35443	484	520	496	531	Repeat	Note=TSP type-3 2
THBS4	P35443	329	375	330	341	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS4	P35443	329	375	335	350	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS4	P35443	329	375	353	377	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS4	P35443	484	520	487	507	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
TIAL1	Q01085	185	217	1	375	Chain	ID=PRO_0000081978;Note=Nucleolysin TIAR
TIAL1	Q01085	43	76	1	375	Chain	ID=PRO_0000081978;Note=Nucleolysin TIAR
TIAL1	Q01085	43	76	9	85	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
TIAL1	Q01085	185	217	205	277	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
TIAL1	Q01085	185	217	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
TIAL1	Q01085	43	76	43	43	Alternative sequence	ID=VSP_043700;Note=In isoform 2. E->EQPDSRRVNSSVGFSVLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TIAL1	Q01085	43	76	50	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQI
TIAL1	Q01085	43	76	58	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQI
TIAL1	Q01085	43	76	71	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQI
TIAL1	Q01085	43	76	76	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQI
TIAL1	Q01085	185	217	193	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X4G
TIAL1	Q01085	185	217	206	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X4G
SPOCK1	Q08629	330	376	22	439	Chain	ID=PRO_0000026699;Note=Testican-1
SPOCK1	Q08629	196	235	22	439	Chain	ID=PRO_0000026699;Note=Testican-1
SPOCK1	Q08629	330	376	310	376	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
SPOCK1	Q08629	196	235	228	228	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23234360;Dbxref=PMID:23234360
SPOCK1	Q08629	330	376	313	337	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPOCK1	Q08629	330	376	348	355	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPOCK1	Q08629	330	376	357	376	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
TIMELESS	Q9UNS1	303	362	1	1208	Chain	ID=PRO_0000072538;Note=Protein timeless homolog
TIMELESS	Q9UNS1	177	229	1	1208	Chain	ID=PRO_0000072538;Note=Protein timeless homolog
TIMELESS	Q9UNS1	143	177	1	1208	Chain	ID=PRO_0000072538;Note=Protein timeless homolog
TIMELESS	Q9UNS1	303	362	1	309	Region	Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250
TIMELESS	Q9UNS1	177	229	1	309	Region	Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250
TIMELESS	Q9UNS1	143	177	1	309	Region	Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250
TIMELESS	Q9UNS1	177	229	177	177	Alternative sequence	ID=VSP_051693;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9856465;Dbxref=PMID:15489334,PMID:9856465
TIMELESS	Q9UNS1	143	177	177	177	Alternative sequence	ID=VSP_051693;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9856465;Dbxref=PMID:15489334,PMID:9856465
TIMELESS	Q9UNS1	143	177	145	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	143	177	150	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	177	229	184	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	177	229	198	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	177	229	209	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	177	229	215	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	177	229	226	228	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	303	362	336	352	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMELESS	Q9UNS1	303	362	354	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI
TIMM44	O43615	104	131	128	128	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TIMM44	O43615	329	346	323	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	329	346	336	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	346	376	345	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	329	346	345	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	376	413	368	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	346	376	368	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	376	413	386	398	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	376	413	400	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TIMM44	O43615	376	413	408	411	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CW9
TINAGL1	Q9GZM7	125	155	22	467	Chain	ID=PRO_0000026482;Note=Tubulointerstitial nephritis antigen-like
TINAGL1	Q9GZM7	125	155	1	134	Alternative sequence	ID=VSP_013094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15498874,ECO:0000303|Ref.5;Dbxref=PMID:15498874
TINAGL1	Q9GZM7	125	155	126	156	Alternative sequence	ID=VSP_043712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TINAGL1	Q9GZM7	125	155	135	194	Alternative sequence	ID=VSP_013095;Note=In isoform 2. CDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIY->MVLGSSTQVKIGGSWNPAAAGGLKIKLQKALDLVALQCQWAPEGQARAEQEADRATFILQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15498874,ECO:0000303|Ref.5;Dbxref=PMID:15498874
TAC3	Q9UHF0	79	97	81	90	Peptide	ID=PRO_0000033566;Note=Neurokinin-B
TAC3	Q9UHF0	79	97	81	90	Peptide	ID=PRO_0000033566;Note=Neurokinin-B
TAC3	Q9UHF0	79	97	94	121	Propeptide	ID=PRO_0000033567;Ontology_term=ECO:0000250;evidence=ECO:0000250
TAC3	Q9UHF0	79	97	94	121	Propeptide	ID=PRO_0000033567;Ontology_term=ECO:0000250;evidence=ECO:0000250
TAC3	Q9UHF0	79	97	90	90	Modified residue	Note=Methionine amide;Ontology_term=ECO:0000250;evidence=ECO:0000250
TAC3	Q9UHF0	79	97	90	90	Modified residue	Note=Methionine amide;Ontology_term=ECO:0000250;evidence=ECO:0000250
TAC3	Q9UHF0	79	97	80	98	Alternative sequence	ID=VSP_013186;Note=In isoform 3. RDMHDFFVGLMGKRSVQPD->H;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TAC3	Q9UHF0	79	97	80	98	Alternative sequence	ID=VSP_013186;Note=In isoform 3. RDMHDFFVGLMGKRSVQPD->H;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
TAC3	Q9UHF0	79	97	80	80	Natural variant	ID=VAR_069969;Note=In HH10%3B phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism%3B the patient also carries a mutation in HS6ST1. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs727505372,PMID:23643382
TAC3	Q9UHF0	79	97	80	80	Natural variant	ID=VAR_069969;Note=In HH10%3B phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism%3B the patient also carries a mutation in HS6ST1. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23643382;Dbxref=dbSNP:rs727505372,PMID:23643382
TAC3	Q9UHF0	79	97	90	90	Natural variant	ID=VAR_069176;Note=In HH10%3B has markedly reduced activity. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19079066;Dbxref=dbSNP:rs121918123,PMID:19079066
TAC3	Q9UHF0	79	97	90	90	Natural variant	ID=VAR_069176;Note=In HH10%3B has markedly reduced activity. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19079066;Dbxref=dbSNP:rs121918123,PMID:19079066
TAC3	Q9UHF0	79	97	82	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P9F
TAC3	Q9UHF0	79	97	82	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P9F
TKT	P29401	146	209	1	623	Chain	ID=PRO_0000191894;Note=Transketolase
TKT	P29401	146	209	1	623	Chain	ID=PRO_0000191894;Note=Transketolase
TKT	P29401	146	209	155	155	Metal binding	Note=Magnesium
TKT	P29401	146	209	155	155	Metal binding	Note=Magnesium
TKT	P29401	146	209	185	185	Metal binding	Note=Magnesium
TKT	P29401	146	209	185	185	Metal binding	Note=Magnesium
TKT	P29401	146	209	187	187	Metal binding	Note=Magnesium%3B via carbonyl oxygen
TKT	P29401	146	209	187	187	Metal binding	Note=Magnesium%3B via carbonyl oxygen
TKT	P29401	146	209	156	156	Binding site	Note=Thiamine pyrophosphate%3B via amide nitrogen
TKT	P29401	146	209	156	156	Binding site	Note=Thiamine pyrophosphate%3B via amide nitrogen
TKT	P29401	146	209	185	185	Binding site	Note=Thiamine pyrophosphate
TKT	P29401	146	209	185	185	Binding site	Note=Thiamine pyrophosphate
TKT	P29401	146	209	204	204	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TKT	P29401	146	209	204	204	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TKT	P29401	146	209	146	146	Alternative sequence	ID=VSP_045566;Note=In isoform 2. S->SLPSSWDYS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TKT	P29401	146	209	146	146	Alternative sequence	ID=VSP_045566;Note=In isoform 2. S->SLPSSWDYS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TKT	P29401	146	209	181	181	Natural variant	ID=VAR_052634;Note=I->V;Dbxref=dbSNP:rs17052920
TKT	P29401	146	209	181	181	Natural variant	ID=VAR_052634;Note=I->V;Dbxref=dbSNP:rs17052920
TKT	P29401	146	209	149	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	149	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	156	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	156	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	161	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	161	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	178	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	178	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	189	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	189	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	194	197	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	194	197	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	199	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TKT	P29401	146	209	199	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KXV
TLK2	Q86UE8	27	51	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	89	121	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	121	177	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	177	209	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	209	240	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	240	277	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	374	395	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	509	538	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	679	715	1	772	Chain	ID=PRO_0000086754;Note=Serine/threonine-protein kinase tousled-like 2
TLK2	Q86UE8	509	538	462	741	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TLK2	Q86UE8	679	715	462	741	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TLK2	Q86UE8	209	240	225	276	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TLK2	Q86UE8	240	277	225	276	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TLK2	Q86UE8	89	121	94	94	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163
TLK2	Q86UE8	89	121	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
TLK2	Q86UE8	89	121	115	115	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TLK2	Q86UE8	89	121	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TLK2	Q86UE8	121	177	134	134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163
TLK2	Q86UE8	89	121	90	121	Alternative sequence	ID=VSP_050572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9427565;Dbxref=PMID:9427565
TLK2	Q86UE8	121	177	90	121	Alternative sequence	ID=VSP_050572;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9427565;Dbxref=PMID:9427565
TLK2	Q86UE8	374	395	375	396	Alternative sequence	ID=VSP_050573;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10523312,ECO:0000303|PubMed:9427565;Dbxref=PMID:10523312,PMID:9427565
TLK2	Q86UE8	89	121	95	95	Natural variant	ID=VAR_041218;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2598147,PMID:17344846
TLK2	Q86UE8	89	121	108	108	Natural variant	ID=VAR_041219;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
TLK2	Q86UE8	89	121	109	109	Natural variant	ID=VAR_041220;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
TLK2	Q86UE8	121	177	173	173	Natural variant	ID=VAR_041221;Note=In a gastric adenocarcinoma sample%3B somatic mutation. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
TLK2	Q86UE8	240	277	262	262	Natural variant	ID=VAR_041222;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs762409144,PMID:17344846
TLK2	Q86UE8	121	177	161	161	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLK2	Q86UE8	177	209	207	207	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TLK2	Q86UE8	509	538	502	519	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLK2	Q86UE8	509	538	529	534	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLK2	Q86UE8	679	715	680	682	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLK2	Q86UE8	679	715	687	693	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLK2	Q86UE8	679	715	694	698	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLK2	Q86UE8	679	715	706	708	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLK2	Q86UE8	679	715	712	721	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5O0Y
TLE2	Q04725	241	291	1	743	Chain	ID=PRO_0000051278;Note=Transducin-like enhancer protein 2
TLE2	Q04725	77	98	1	743	Chain	ID=PRO_0000051278;Note=Transducin-like enhancer protein 2
TLE2	Q04725	77	98	1	127	Region	Note=Q domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04724
TLE2	Q04725	241	291	192	254	Region	Note=CcN domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04724
TLE2	Q04725	241	291	255	423	Region	Note=SP domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04724
TLE2	Q04725	241	291	249	249	Modified residue	Note=Phosphoserine%3B by CDK1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TLE2	Q04725	241	291	253	253	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000255;evidence=ECO:0000255
TLE2	Q04725	241	291	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TLE2	Q04725	241	291	280	280	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM39A	Q9NV64	112	140	1	488	Chain	ID=PRO_0000279224;Note=Transmembrane protein 39A
TMEM39A	Q9NV64	112	140	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM254	Q8TBM7	64	83	2	123	Chain	ID=PRO_0000089796;Note=Transmembrane protein 254
TMEM254	Q8TBM7	64	83	61	81	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM254	Q8TBM7	64	83	76	76	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM254	Q8TBM7	64	83	81	81	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM41A	Q96HV5	91	145	18	264	Chain	ID=PRO_0000271775;Note=Transmembrane protein 41A
TMEM41A	Q96HV5	91	145	100	122	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM41A	Q96HV5	91	145	96	207	Region	Note=VTT domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30093494;Dbxref=PMID:30093494
TMEM52B	Q4KMG9	33	45	25	183	Chain	ID=PRO_0000294448;Note=Transmembrane protein 52B
TMEM52B	Q4KMG9	33	45	40	60	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM52B	Q4KMG9	33	45	1	33	Alternative sequence	ID=VSP_026640;Note=In isoform 2. MGVRVHVVAASALLYFILLSGTRCEENCGNPEH->MSWRPQPCCISSC;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:12975309,PMID:14702039
TPRG1L	Q5T0D9	98	156	1	272	Chain	ID=PRO_0000269186;Note=Tumor protein p63-regulated gene 1-like protein
TPRG1L	Q5T0D9	98	156	65	238	Domain	Note=hSac2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01127
TPRG1L	Q5T0D9	98	156	99	157	Alternative sequence	ID=VSP_022019;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TRPM6	Q9BX84	846	889	1	2022	Chain	ID=PRO_0000215329;Note=Transient receptor potential cation channel subfamily M member 6
TRPM6	Q9BX84	797	846	1	2022	Chain	ID=PRO_0000215329;Note=Transient receptor potential cation channel subfamily M member 6
TRPM6	Q9BX84	546	577	1	2022	Chain	ID=PRO_0000215329;Note=Transient receptor potential cation channel subfamily M member 6
TRPM6	Q9BX84	499	546	1	2022	Chain	ID=PRO_0000215329;Note=Transient receptor potential cation channel subfamily M member 6
TRPM6	Q9BX84	546	577	1	741	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM6	Q9BX84	499	546	1	741	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM6	Q9BX84	797	846	763	841	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM6	Q9BX84	846	889	842	862	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM6	Q9BX84	797	846	842	862	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM6	Q9BX84	846	889	863	905	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM6	Q9BX84	846	889	282	1734	Alternative sequence	ID=VSP_012072;Note=In isoform M6-kinase 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	797	846	282	1734	Alternative sequence	ID=VSP_012072;Note=In isoform M6-kinase 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	546	577	282	1734	Alternative sequence	ID=VSP_012072;Note=In isoform M6-kinase 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	499	546	282	1734	Alternative sequence	ID=VSP_012072;Note=In isoform M6-kinase 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	846	889	500	1666	Alternative sequence	ID=VSP_012073;Note=In isoform M6-kinase 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	797	846	500	1666	Alternative sequence	ID=VSP_012073;Note=In isoform M6-kinase 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	546	577	500	1666	Alternative sequence	ID=VSP_012073;Note=In isoform M6-kinase 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	499	546	500	1666	Alternative sequence	ID=VSP_012073;Note=In isoform M6-kinase 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	846	889	547	1595	Alternative sequence	ID=VSP_012074;Note=In isoform M6-kinase 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	797	846	547	1595	Alternative sequence	ID=VSP_012074;Note=In isoform M6-kinase 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	546	577	547	1595	Alternative sequence	ID=VSP_012074;Note=In isoform M6-kinase 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14976260;Dbxref=PMID:14976260
TRPM6	Q9BX84	846	889	872	872	Natural variant	ID=VAR_071481;Note=In HOMG1%3B loss of function%3B no effect on cell membrane localization. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23942199;Dbxref=PMID:23942199
TRPM7	Q96QT4	860	903	1	1865	Chain	ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7
TRPM7	Q96QT4	498	545	1	1865	Chain	ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7
TRPM7	Q96QT4	480	498	1	1865	Chain	ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7
TRPM7	Q96QT4	498	545	1	755	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM7	Q96QT4	480	498	1	755	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM7	Q96QT4	860	903	856	876	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPM7	Q96QT4	860	903	877	918	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAF1A	Q15573	97	135	1	450	Chain	ID=PRO_0000227987;Note=TATA box-binding protein-associated factor RNA polymerase I subunit A
TAF1A	Q15573	97	135	1	450	Chain	ID=PRO_0000227987;Note=TATA box-binding protein-associated factor RNA polymerase I subunit A
TAF1A	Q15573	97	135	1	114	Alternative sequence	ID=VSP_017635;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAF1A	Q15573	97	135	1	114	Alternative sequence	ID=VSP_017635;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TAF1A	Q15573	97	135	98	98	Natural variant	ID=VAR_052253;Note=I->M;Dbxref=dbSNP:rs17163271
TAF1A	Q15573	97	135	98	98	Natural variant	ID=VAR_052253;Note=I->M;Dbxref=dbSNP:rs17163271
THSD1	Q9NS62	19	340	1	24	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	340	393	25	852	Chain	ID=PRO_0000249584;Note=Thrombospondin type-1 domain-containing protein 1
THSD1	Q9NS62	19	340	25	852	Chain	ID=PRO_0000249584;Note=Thrombospondin type-1 domain-containing protein 1
THSD1	Q9NS62	340	393	25	413	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	25	413	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	340	393	340	393	Domain	Note=TSP type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD1	Q9NS62	19	340	340	393	Domain	Note=TSP type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD1	Q9NS62	19	340	39	39	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	53	53	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	58	58	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	69	69	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	80	80	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	19	340	304	304	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THSD1	Q9NS62	340	393	352	387	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD1	Q9NS62	340	393	356	392	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD1	Q9NS62	340	393	367	377	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THSD1	Q9NS62	340	393	341	393	Alternative sequence	ID=VSP_020521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
THSD1	Q9NS62	19	340	125	125	Natural variant	ID=VAR_027474;Note=V->G;Dbxref=dbSNP:rs13313279
THSD1	Q9NS62	19	340	224	224	Natural variant	ID=VAR_027475;Note=R->G;Dbxref=dbSNP:rs9536062
THUMPD2	Q9BTF0	224	250	1	503	Chain	ID=PRO_0000072532;Note=THUMP domain-containing protein 2
THUMPD2	Q9BTF0	224	250	161	266	Domain	Note=THUMP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00529
SPOCK2	Q92563	309	330	23	424	Chain	ID=PRO_0000026701;Note=Testican-2
SPOCK2	Q92563	196	236	23	424	Chain	ID=PRO_0000026701;Note=Testican-2
SPOCK2	Q92563	309	330	23	424	Chain	ID=PRO_0000026701;Note=Testican-2
SPOCK2	Q92563	196	236	23	424	Chain	ID=PRO_0000026701;Note=Testican-2
SPOCK2	Q92563	309	330	310	376	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
SPOCK2	Q92563	309	330	310	376	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
SPOCK2	Q92563	196	236	225	225	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPOCK2	Q92563	196	236	225	225	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SPOCK2	Q92563	309	330	313	337	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPOCK2	Q92563	309	330	313	337	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPOCK2	Q92563	309	330	78	424	Alternative sequence	ID=VSP_045669;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCK2	Q92563	196	236	78	424	Alternative sequence	ID=VSP_045669;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCK2	Q92563	309	330	78	424	Alternative sequence	ID=VSP_045669;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPOCK2	Q92563	196	236	78	424	Alternative sequence	ID=VSP_045669;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TICRR	Q7Z2Z1	1825	1867	1	1910	Chain	ID=PRO_0000296623;Note=Treslin
LRRC6	Q86X45	305	324	1	466	Chain	ID=PRO_0000084496;Note=Protein tilB homolog
LRRC6	Q86X45	305	324	301	396	Domain	Note=CS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00547
TIMM50	Q3ZCQ8	124	164	45	353	Chain	ID=PRO_0000043115;Note=Mitochondrial import inner membrane translocase subunit TIM50
TIMM50	Q3ZCQ8	164	199	45	353	Chain	ID=PRO_0000043115;Note=Mitochondrial import inner membrane translocase subunit TIM50
TIMM50	Q3ZCQ8	124	164	87	353	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMM50	Q3ZCQ8	164	199	87	353	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIMM50	Q3ZCQ8	124	164	143	286	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
TIMM50	Q3ZCQ8	164	199	143	286	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
TIMM50	Q3ZCQ8	124	164	12	124	Alternative sequence	ID=VSP_047683;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
TIMM50	Q3ZCQ8	124	164	149	149	Natural variant	ID=VAR_078569;Note=In MGCA9%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27573165;Dbxref=dbSNP:rs1244226820,PMID:27573165
TJAP1	Q5JTD0	119	129	2	557	Chain	ID=PRO_0000072550;Note=Tight junction-associated protein 1
TJAP1	Q5JTD0	119	129	2	557	Chain	ID=PRO_0000072550;Note=Tight junction-associated protein 1
TJAP1	Q5JTD0	119	129	2	557	Chain	ID=PRO_0000072550;Note=Tight junction-associated protein 1
TJAP1	Q5JTD0	119	129	36	175	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TJAP1	Q5JTD0	119	129	36	175	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TJAP1	Q5JTD0	119	129	36	175	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TJAP1	Q5JTD0	119	129	44	557	Alternative sequence	ID=VSP_016000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TJAP1	Q5JTD0	119	129	44	557	Alternative sequence	ID=VSP_016000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TJAP1	Q5JTD0	119	129	44	557	Alternative sequence	ID=VSP_016000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
TJAP1	Q5JTD0	119	129	120	129	Alternative sequence	ID=VSP_016002;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
TJAP1	Q5JTD0	119	129	120	129	Alternative sequence	ID=VSP_016002;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
TJAP1	Q5JTD0	119	129	120	129	Alternative sequence	ID=VSP_016002;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
TIRAP	P58753	22	215	1	221	Chain	ID=PRO_0000072547;Note=Toll/interleukin-1 receptor domain-containing adapter protein
TIRAP	P58753	22	215	1	221	Chain	ID=PRO_0000072547;Note=Toll/interleukin-1 receptor domain-containing adapter protein
TIRAP	P58753	22	215	84	221	Domain	Note=TIR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00204
TIRAP	P58753	22	215	84	221	Domain	Note=TIR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00204
TIRAP	P58753	22	215	89	134	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21873236;Dbxref=PMID:21873236
TIRAP	P58753	22	215	89	134	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21873236;Dbxref=PMID:21873236
TIRAP	P58753	22	215	142	174	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21873236;Dbxref=PMID:21873236
TIRAP	P58753	22	215	142	174	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21873236;Dbxref=PMID:21873236
TIRAP	P58753	22	215	55	55	Natural variant	ID=VAR_036691;Note=Does not affect NF-kappa-B activation and TNF-alpha production. S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11544529,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3802813,PMID:11544529,PMID:14702039
TIRAP	P58753	22	215	55	55	Natural variant	ID=VAR_036691;Note=Does not affect NF-kappa-B activation and TNF-alpha production. S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11544529,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3802813,PMID:11544529,PMID:14702039
TIRAP	P58753	22	215	96	96	Natural variant	ID=VAR_019145;Note=Hypomorphic variant resulting in impaired NF-kappa-B activation and TNF-alpha production%3B cannot bind MYD88. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19509286,ECO:0000269|Ref.7;Dbxref=dbSNP:rs8177400,PMID:19509286
TIRAP	P58753	22	215	96	96	Natural variant	ID=VAR_019145;Note=Hypomorphic variant resulting in impaired NF-kappa-B activation and TNF-alpha production%3B cannot bind MYD88. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19509286,ECO:0000269|Ref.7;Dbxref=dbSNP:rs8177400,PMID:19509286
TIRAP	P58753	22	215	180	180	Natural variant	ID=VAR_019146;Note=At heterozygosity it protects against invasive pneumococcal disease%2C malaria%2C bacteremia and tuberculosis%3B does not affect NF-kappa-B activation and TNF-alpha production%3B attenuates TLR2 signal transduction. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17322885,ECO:0000269|PubMed:19509286,ECO:0000269|PubMed:19602285,ECO:0000269|Ref.7;Dbxref=dbSNP:rs8177374,PMID:17322885,PMID:19509286,PMID:19602285
TIRAP	P58753	22	215	180	180	Natural variant	ID=VAR_019146;Note=At heterozygosity it protects against invasive pneumococcal disease%2C malaria%2C bacteremia and tuberculosis%3B does not affect NF-kappa-B activation and TNF-alpha production%3B attenuates TLR2 signal transduction. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17322885,ECO:0000269|PubMed:19509286,ECO:0000269|PubMed:19602285,ECO:0000269|Ref.7;Dbxref=dbSNP:rs8177374,PMID:17322885,PMID:19509286,PMID:19602285
TIRAP	P58753	22	215	197	197	Natural variant	ID=VAR_061713;Note=Does not affect NF-kappa-B activation and TNF-alpha production. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19509286;Dbxref=dbSNP:rs7932976,PMID:19509286
TIRAP	P58753	22	215	197	197	Natural variant	ID=VAR_061713;Note=Does not affect NF-kappa-B activation and TNF-alpha production. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19509286;Dbxref=dbSNP:rs7932976,PMID:19509286
TIRAP	P58753	22	215	125	125	Mutagenesis	Note=Abolishes NF-kappa-B activation. P->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11526399,ECO:0000269|PubMed:11544529;Dbxref=PMID:11526399,PMID:11544529
TIRAP	P58753	22	215	125	125	Mutagenesis	Note=Abolishes NF-kappa-B activation. P->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11526399,ECO:0000269|PubMed:11544529;Dbxref=PMID:11526399,PMID:11544529
TIRAP	P58753	22	215	17	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T7Q
TIRAP	P58753	22	215	17	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T7Q
TIRAP	P58753	22	215	83	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	83	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	94	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	94	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	97	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	97	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NDH
TIRAP	P58753	22	215	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NDH
TIRAP	P58753	22	215	131	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	131	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	135	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NDH
TIRAP	P58753	22	215	135	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NDH
TIRAP	P58753	22	215	140	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	140	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	149	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	149	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	155	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	155	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	168	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	168	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	189	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	189	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	202	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	202	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TIRAP	P58753	22	215	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UB2
TAPBPL	Q9BX59	21	98	19	468	Chain	ID=PRO_0000014993;Note=Tapasin-related protein
TAPBPL	Q9BX59	188	301	19	468	Chain	ID=PRO_0000014993;Note=Tapasin-related protein
TAPBPL	Q9BX59	301	402	19	468	Chain	ID=PRO_0000014993;Note=Tapasin-related protein
TAPBPL	Q9BX59	402	430	19	468	Chain	ID=PRO_0000014993;Note=Tapasin-related protein
TAPBPL	Q9BX59	21	98	19	405	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAPBPL	Q9BX59	188	301	19	405	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAPBPL	Q9BX59	301	402	19	405	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAPBPL	Q9BX59	402	430	19	405	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAPBPL	Q9BX59	402	430	406	426	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAPBPL	Q9BX59	402	430	427	468	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TAPBPL	Q9BX59	188	301	181	297	Domain	Note=Ig-like V-type
TAPBPL	Q9BX59	301	402	304	394	Domain	Note=Ig-like C1-type
TAPBPL	Q9BX59	188	301	212	283	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
TAPBPL	Q9BX59	301	402	321	382	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
TAPBPL	Q9BX59	188	301	189	402	Alternative sequence	ID=VSP_057089;Note=In isoform epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	301	402	189	402	Alternative sequence	ID=VSP_057089;Note=In isoform epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	402	430	189	402	Alternative sequence	ID=VSP_057089;Note=In isoform epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	188	301	236	298	Alternative sequence	ID=VSP_057090;Note=In isoform eta. QLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQL->RGDLHLPDHHLSVPSSADHPAQHPRAENSLGSHLCQQSLPSCTDVPGASETASTYRTWAASG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	188	301	236	262	Alternative sequence	ID=VSP_057091;Note=In isoform delta. QLVYSWTAGQGQAVRKGATLEPAQLGM->RGDLHLPDHHLSVPSSADHPAQHPSFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	188	301	263	468	Alternative sequence	ID=VSP_057092;Note=In isoform delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	301	402	263	468	Alternative sequence	ID=VSP_057092;Note=In isoform delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	402	430	263	468	Alternative sequence	ID=VSP_057092;Note=In isoform delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	188	301	299	468	Alternative sequence	ID=VSP_057093;Note=In isoform eta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	301	402	299	468	Alternative sequence	ID=VSP_057093;Note=In isoform eta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	402	430	299	468	Alternative sequence	ID=VSP_057093;Note=In isoform eta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	301	402	302	402	Alternative sequence	ID=VSP_057094;Note=In isoform gamma. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	402	430	302	402	Alternative sequence	ID=VSP_057094;Note=In isoform gamma. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	402	430	430	468	Alternative sequence	ID=VSP_057095;Note=In isoform zeta. QAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS->QEASAFLHCAPWAHAPRQRTGRSEGTRRRQNVQMEDKTKEPGWWCDGRKTKLEEMEKEQVRDNEAWVGAGLPLPNSALSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	402	430	430	430	Alternative sequence	ID=VSP_057096;Note=In isoform beta. Q->QEASAFLHCAPWAHAPRQRTGRSEGTRRRQNVQMEDKTKEP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24444341;Dbxref=PMID:24444341
TAPBPL	Q9BX59	21	98	42	42	Natural variant	ID=VAR_071757;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2041385,PMID:14702039,PMID:15489334
TAPBPL	Q9BX59	301	402	334	334	Natural variant	ID=VAR_056090;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11920573;Dbxref=dbSNP:rs1045546,PMID:11920573
TAPBPL	Q9BX59	21	98	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	21	98	62	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	21	98	87	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	187	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	198	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	207	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	218	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	222	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	234	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	246	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	263	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	268	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	275	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	279	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	188	301	291	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	301	402	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	301	402	318	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TAPBPL	Q9BX59	301	402	363	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WER
TRO	Q12816	15	412	1	1431	Chain	ID=PRO_0000156742;Note=Trophinin
TRO	Q12816	567	587	1	1431	Chain	ID=PRO_0000156742;Note=Trophinin
TRO	Q12816	567	587	444	642	Domain	Note=MAGE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00127
TRO	Q12816	15	412	1	469	Alternative sequence	ID=VSP_053937;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRO	Q12816	15	412	16	412	Alternative sequence	ID=VSP_053938;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRO	Q12816	15	412	65	65	Natural variant	ID=VAR_062122;Note=R->W;Dbxref=dbSNP:rs60674633
TRPV1	Q8NER1	348	408	1	839	Chain	ID=PRO_0000215338;Note=Transient receptor potential cation channel subfamily V member 1
TRPV1	Q8NER1	348	408	1	839	Chain	ID=PRO_0000215338;Note=Transient receptor potential cation channel subfamily V member 1
TRPV1	Q8NER1	348	408	1	839	Chain	ID=PRO_0000215338;Note=Transient receptor potential cation channel subfamily V member 1
TRPV1	Q8NER1	348	408	1	433	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433
TRPV1	Q8NER1	348	408	1	433	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433
TRPV1	Q8NER1	348	408	1	433	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433
TRPV1	Q8NER1	348	408	333	359	Repeat	Note=ANK 6
TRPV1	Q8NER1	348	408	333	359	Repeat	Note=ANK 6
TRPV1	Q8NER1	348	408	333	359	Repeat	Note=ANK 6
TRPV1	Q8NER1	348	408	371	371	Modified residue	Note=Phosphothreonine%3B by PKA%3B in vitro;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433
TRPV1	Q8NER1	348	408	371	371	Modified residue	Note=Phosphothreonine%3B by PKA%3B in vitro;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433
TRPV1	Q8NER1	348	408	371	371	Modified residue	Note=Phosphothreonine%3B by PKA%3B in vitro;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433
TRPV3	Q8NET8	75	103	1	790	Chain	ID=PRO_0000215345;Note=Transient receptor potential cation channel subfamily V member 3
TRPV3	Q8NET8	75	103	1	439	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TIAM1	Q13009	858	887	2	1591	Chain	ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1
TIAM1	Q13009	796	831	2	1591	Chain	ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1
TIAM1	Q13009	714	739	2	1591	Chain	ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1
TIAM1	Q13009	796	831	765	832	Domain	Note=RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00262
TIAM1	Q13009	858	887	845	908	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
TIAM1	Q13009	796	831	829	829	Modified residue	Note=Phosphotyrosine%3B by NTRK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60610
TIAM1	Q13009	714	739	715	739	Alternative sequence	ID=VSP_055865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TIAM1	Q13009	796	831	797	831	Alternative sequence	ID=VSP_055866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TIAM1	Q13009	858	887	879	879	Mutagenesis	Note=Strongly reduces affinity for SDC1. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23395182;Dbxref=PMID:23395182
TIAM1	Q13009	858	887	881	881	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TIAM1	Q13009	858	887	855	858	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZE
TIAM1	Q13009	858	887	859	865	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD
TIAM1	Q13009	858	887	867	870	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD
TIAM1	Q13009	858	887	872	878	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD
TIAM1	Q13009	858	887	883	886	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD
TRAPPC3	O43617	80	141	1	180	Chain	ID=PRO_0000211572;Note=Trafficking protein particle complex subunit 3
TRAPPC3	O43617	80	141	71	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	82	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	92	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	102	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	120	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	127	129	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	130	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRAPPC3	O43617	80	141	141	143	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SZ7
TRPC6	Q9Y210	803	828	1	931	Chain	ID=PRO_0000215322;Note=Short transient receptor potential channel 6
TRPC6	Q9Y210	503	581	1	931	Chain	ID=PRO_0000215322;Note=Short transient receptor potential channel 6
TRPC6	Q9Y210	376	431	1	931	Chain	ID=PRO_0000215322;Note=Short transient receptor potential channel 6
TRPC6	Q9Y210	376	431	1	438	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC6	Q9Y210	503	581	488	508	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC6	Q9Y210	503	581	509	521	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC6	Q9Y210	503	581	522	542	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC6	Q9Y210	503	581	543	592	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC6	Q9Y210	803	828	728	931	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRPC6	Q9Y210	803	828	815	815	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18088087;Dbxref=PMID:18088087
TRPC6	Q9Y210	503	581	561	561	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12970363;Dbxref=PMID:12970363
TRPC6	Q9Y210	376	431	316	431	Alternative sequence	ID=VSP_006572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10816590;Dbxref=PMID:10816590
TRPC6	Q9Y210	376	431	377	431	Alternative sequence	ID=VSP_006573;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10816590;Dbxref=PMID:10816590
TRPC6	Q9Y210	376	431	395	395	Natural variant	ID=VAR_079789;Note=In FSGS2%3B unknown pathological significance%3B requires 2 nucleotide substitutions%3B decreases calcium ion transport. L->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21511817,ECO:0000269|PubMed:26892346;Dbxref=PMID:21511817,PMID:26892346
TRPC6	Q9Y210	376	431	404	404	Natural variant	ID=VAR_061861;Note=Polymorphism%3B increases calcium ion transport. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19936226,ECO:0000269|PubMed:21511817,ECO:0000269|PubMed:26892346;Dbxref=dbSNP:rs36111323,PMID:19936226,PMID:21511817,PMID:26892346
TRPC6	Q9Y210	503	581	561	561	Mutagenesis	Note=Constitutively activates channel. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12970363;Dbxref=PMID:12970363
TRPC6	Q9Y210	803	828	826	827	Mutagenesis	Note=Decreases calcium ion transport. KK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26892346;Dbxref=PMID:26892346
TRPM4	Q8TD43	711	736	1	1214	Chain	ID=PRO_0000259529;Note=Transient receptor potential cation channel subfamily M member 4
TRPM4	Q8TD43	737	881	1	1214	Chain	ID=PRO_0000259529;Note=Transient receptor potential cation channel subfamily M member 4
TRPM4	Q8TD43	711	736	1	782	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	1	782	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	783	803	Transmembrane	Note=Helical;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	804	814	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	815	835	Transmembrane	Note=Helical;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	836	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	864	884	Transmembrane	Note=Helical;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29211723,ECO:0000269|PubMed:29217581;Dbxref=PMID:29211723,PMID:29217581
TRPM4	Q8TD43	737	881	828	828	Metal binding	Note=Calcium;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BQV,ECO:0000269|PubMed:29217581;Dbxref=PMID:29217581
TRPM4	Q8TD43	737	881	831	831	Metal binding	Note=Calcium;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BQV,ECO:0000269|PubMed:29217581;Dbxref=PMID:29217581
TRPM4	Q8TD43	737	881	865	865	Metal binding	Note=Calcium;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BQV,ECO:0000269|PubMed:29217581;Dbxref=PMID:29217581
TRPM4	Q8TD43	737	881	868	868	Metal binding	Note=Calcium;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PDB:6BQV,ECO:0000305|PubMed:29217581;Dbxref=PMID:29217581
TRPM4	Q8TD43	737	881	738	882	Alternative sequence	ID=VSP_021443;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12842017;Dbxref=PMID:12842017
TRPM4	Q8TD43	737	881	790	790	Natural variant	ID=VAR_066771;Note=In PFHB1B%3B atrioventricular block. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21887725;Dbxref=dbSNP:rs172150857,PMID:21887725
TRPM4	Q8TD43	737	881	844	844	Natural variant	ID=VAR_066772;Note=In PFHB1B%3B right bundle-branch block. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20562447,ECO:0000269|PubMed:21887725;Dbxref=dbSNP:rs200038418,PMID:20562447,PMID:21887725
TRPM4	Q8TD43	737	881	854	854	Natural variant	ID=VAR_066773;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21887725;Dbxref=dbSNP:rs172155862,PMID:21887725
TRPM4	Q8TD43	737	881	768	776	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TRPM4	Q8TD43	737	881	779	803	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TRPM4	Q8TD43	737	881	807	809	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TRPM4	Q8TD43	737	881	812	829	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TRPM4	Q8TD43	737	881	830	834	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TRPM4	Q8TD43	737	881	852	859	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TRPM4	Q8TD43	737	881	863	883	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BQV
TSGA10	Q9BZW7	641	690	1	698	Chain	ID=PRO_0000307125;Note=Testis-specific gene 10 protein
TSGA10	Q9BZW7	468	538	1	698	Chain	ID=PRO_0000307125;Note=Testis-specific gene 10 protein
TSGA10	Q9BZW7	641	690	1	698	Chain	ID=PRO_0000307125;Note=Testis-specific gene 10 protein
TSGA10	Q9BZW7	468	538	1	698	Chain	ID=PRO_0000307125;Note=Testis-specific gene 10 protein
TSGA10	Q9BZW7	641	690	1	698	Chain	ID=PRO_0000307125;Note=Testis-specific gene 10 protein
TSGA10	Q9BZW7	468	538	1	698	Chain	ID=PRO_0000307125;Note=Testis-specific gene 10 protein
TSGA10	Q9BZW7	641	690	556	689	Region	Note=Interaction with HIF1A;Ontology_term=ECO:0000250;evidence=ECO:0000250
TSGA10	Q9BZW7	641	690	556	689	Region	Note=Interaction with HIF1A;Ontology_term=ECO:0000250;evidence=ECO:0000250
TSGA10	Q9BZW7	641	690	556	689	Region	Note=Interaction with HIF1A;Ontology_term=ECO:0000250;evidence=ECO:0000250
TSGA10	Q9BZW7	641	690	688	688	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z220
TSGA10	Q9BZW7	641	690	688	688	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z220
TSGA10	Q9BZW7	641	690	688	688	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z220
TSGA10	Q9BZW7	641	690	298	698	Alternative sequence	ID=VSP_054410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSGA10	Q9BZW7	468	538	298	698	Alternative sequence	ID=VSP_054410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSGA10	Q9BZW7	641	690	298	698	Alternative sequence	ID=VSP_054410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSGA10	Q9BZW7	468	538	298	698	Alternative sequence	ID=VSP_054410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSGA10	Q9BZW7	641	690	298	698	Alternative sequence	ID=VSP_054410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSGA10	Q9BZW7	468	538	298	698	Alternative sequence	ID=VSP_054410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
THBS1	P07996	490	548	19	1170	Chain	ID=PRO_0000035842;Note=Thrombospondin-1
THBS1	P07996	490	548	435	490	Domain	Note=TSP type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS1	P07996	490	548	492	547	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS1	P07996	490	548	547	587	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS1	P07996	490	548	498	498	Glycosylation	ID=CAR_000210;Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11067851;Dbxref=PMID:11067851
THBS1	P07996	490	548	507	507	Glycosylation	ID=CAR_000211;Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11067851,ECO:0000269|PubMed:12391027;Dbxref=PMID:11067851,PMID:12391027
THBS1	P07996	490	548	504	541	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1LSL,ECO:0000269|PubMed:12391027;Dbxref=PMID:12391027
THBS1	P07996	490	548	508	546	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1LSL,ECO:0000269|PubMed:12391027;Dbxref=PMID:12391027
THBS1	P07996	490	548	519	531	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1LSL,ECO:0000269|PubMed:12391027;Dbxref=PMID:12391027
THBS1	P07996	490	548	523	523	Natural variant	ID=VAR_028938;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:2918029;Dbxref=dbSNP:rs2292305,PMID:14702039,PMID:2918029
THBS1	P07996	490	548	546	546	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
THBS1	P07996	490	548	507	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LSL
THBS1	P07996	490	548	511	516	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LSL
THBS1	P07996	490	548	535	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LSL
TTC6	Q86TZ1	157	197	1	520	Chain	ID=PRO_0000106384;Note=Tetratricopeptide repeat protein 6
TTC6	Q86TZ1	343	400	1	520	Chain	ID=PRO_0000106384;Note=Tetratricopeptide repeat protein 6
TTC6	Q86TZ1	157	197	1	520	Chain	ID=PRO_0000106384;Note=Tetratricopeptide repeat protein 6
TTC6	Q86TZ1	343	400	1	520	Chain	ID=PRO_0000106384;Note=Tetratricopeptide repeat protein 6
TTC6	Q86TZ1	157	197	139	172	Repeat	Note=TPR 3
TTC6	Q86TZ1	157	197	139	172	Repeat	Note=TPR 3
TTC6	Q86TZ1	157	197	176	209	Repeat	Note=TPR 4
TTC6	Q86TZ1	157	197	176	209	Repeat	Note=TPR 4
TTC6	Q86TZ1	343	400	320	347	Repeat	Note=TPR 8
TTC6	Q86TZ1	343	400	320	347	Repeat	Note=TPR 8
TTC6	Q86TZ1	343	400	348	381	Repeat	Note=TPR 9
TTC6	Q86TZ1	343	400	348	381	Repeat	Note=TPR 9
TTC6	Q86TZ1	343	400	382	415	Repeat	Note=TPR 10
TTC6	Q86TZ1	343	400	382	415	Repeat	Note=TPR 10
TTC6	Q86TZ1	343	400	376	376	Natural variant	ID=VAR_034134;Note=T->S;Dbxref=dbSNP:rs17107176
TTC6	Q86TZ1	343	400	376	376	Natural variant	ID=VAR_034134;Note=T->S;Dbxref=dbSNP:rs17107176
IGSF9	Q9P2J2	19	82	1	20	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF9	Q9P2J2	790	1076	21	1179	Chain	ID=PRO_0000306107;Note=Protein turtle homolog A
IGSF9	Q9P2J2	82	133	21	1179	Chain	ID=PRO_0000306107;Note=Protein turtle homolog A
IGSF9	Q9P2J2	19	82	21	1179	Chain	ID=PRO_0000306107;Note=Protein turtle homolog A
IGSF9	Q9P2J2	82	133	21	734	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF9	Q9P2J2	19	82	21	734	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF9	Q9P2J2	790	1076	756	1179	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
IGSF9	Q9P2J2	82	133	24	124	Domain	Note=Ig-like 1
IGSF9	Q9P2J2	19	82	24	124	Domain	Note=Ig-like 1
IGSF9	Q9P2J2	790	1076	823	982	Compositional bias	Note=Pro-rich
IGSF9	Q9P2J2	790	1076	809	809	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C5H6
IGSF9	Q9P2J2	790	1076	972	972	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
IGSF9	Q9P2J2	82	133	41	108	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF9	Q9P2J2	19	82	41	108	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
IGSF9	Q9P2J2	19	82	34	34	Natural variant	ID=VAR_035256;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3747617,PMID:15489334
IGSF9	Q9P2J2	790	1076	914	914	Natural variant	ID=VAR_035258;Note=P->L;Dbxref=dbSNP:rs35574000
IGSF9	Q9P2J2	790	1076	1026	1026	Natural variant	ID=VAR_035259;Note=S->T;Dbxref=dbSNP:rs34749866
TBATA	Q96M53	169	230	1	351	Chain	ID=PRO_0000089786;Note=Protein TBATA
TUBG1	P23258	110	133	1	451	Chain	ID=PRO_0000048465;Note=Tubulin gamma-1 chain
TUBG1	P23258	231	281	1	451	Chain	ID=PRO_0000048465;Note=Tubulin gamma-1 chain
TUBG1	P23258	110	133	131	131	Modified residue	Note=Phosphoserine%3B by BRSK1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P83887
TUBG1	P23258	110	133	104	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CB2
TUBG1	P23258	231	281	225	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CB2
TUBG1	P23258	231	281	240	243	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CB2
TUBG1	P23258	231	281	244	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CB2
TUBG1	P23258	231	281	248	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z5V
TUBG1	P23258	231	281	253	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CB2
TUBG1	P23258	231	281	262	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z5V
TUBG1	P23258	231	281	268	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CB2
TUBG2	Q9NRH3	54	110	1	451	Chain	ID=PRO_0000048468;Note=Tubulin gamma-2 chain
TUBG2	Q9NRH3	231	281	1	451	Chain	ID=PRO_0000048468;Note=Tubulin gamma-2 chain
TCN2	P20062	142	193	19	427	Chain	ID=PRO_0000005564;Note=Transcobalamin-2
TCN2	P20062	142	193	152	156	Region	Note=Cobalamin binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
TCN2	P20062	142	193	190	194	Region	Note=Cobalamin binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
TCN2	P20062	142	193	190	190	Metal binding	Note=Cobalt (cobalamin axial ligand)
TCN2	P20062	142	193	21	267	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2BB5,ECO:0000244|PDB:4ZRP,ECO:0000244|PDB:4ZRQ,ECO:0000269|PubMed:16537422,ECO:0000269|PubMed:27411955;Dbxref=PMID:16537422,PMID:27411955
TCN2	P20062	142	193	116	309	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2BB5,ECO:0000244|PDB:4ZRP,ECO:0000244|PDB:4ZRQ,ECO:0000269|PubMed:16537422,ECO:0000269|PubMed:27411955;Dbxref=PMID:16537422,PMID:27411955
TCN2	P20062	142	193	165	205	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2BB5,ECO:0000244|PDB:4ZRP,ECO:0000244|PDB:4ZRQ,ECO:0000269|PubMed:16537422,ECO:0000269|PubMed:27411955;Dbxref=PMID:16537422,PMID:27411955
TCN2	P20062	142	193	116	143	Alternative sequence	ID=VSP_043711;Note=In isoform 2. CEFVRGHKGDRLVSQLKWFLEDEKRAIG->W;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCN2	P20062	142	193	121	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
TCN2	P20062	142	193	144	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
TCN2	P20062	142	193	154	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
TCN2	P20062	142	193	173	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
TCN2	P20062	142	193	184	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRQ
TCN2	P20062	142	193	193	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
TGFB1I1	O43294	173	238	1	461	Chain	ID=PRO_0000291582;Note=Transforming growth factor beta-1-induced transcript 1 protein
TGFB1I1	O43294	173	238	226	285	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
TGFB1I1	O43294	173	238	1	240	Region	Note=Interaction with PTK2B/PYK2
TGFB1I1	O43294	173	238	1	200	Region	Note=Transcription activation;Ontology_term=ECO:0000250;evidence=ECO:0000250
TGFB1I1	O43294	173	238	203	215	Motif	Note=LD motif 4
TGFB1I1	O43294	173	238	186	186	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62219
TGFB1I1	O43294	173	238	188	188	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62219
TGFB1I1	O43294	173	238	192	192	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
TGFB1I1	O43294	173	238	194	194	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TGFB1I1	O43294	173	238	200	200	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TGM7	Q96PF1	369	450	1	710	Chain	ID=PRO_0000213716;Note=Protein-glutamine gamma-glutamyltransferase Z
TGM7	Q96PF1	369	450	401	401	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
TGM7	Q96PF1	369	450	403	403	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
TGM7	Q96PF1	369	450	450	450	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
THNSL2	Q86YJ6	74	139	1	484	Chain	ID=PRO_0000306407;Note=Threonine synthase-like 2
THNSL2	Q86YJ6	139	190	1	484	Chain	ID=PRO_0000306407;Note=Threonine synthase-like 2
THNSL2	Q86YJ6	74	139	113	113	Modified residue	Note=N6-(pyridoxal phosphate)lysine;Ontology_term=ECO:0000250;evidence=ECO:0000250
THNSL2	Q86YJ6	74	139	1	158	Alternative sequence	ID=VSP_041659;Note=In isoform SOFAT. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19877052;Dbxref=PMID:19877052
THNSL2	Q86YJ6	139	190	1	158	Alternative sequence	ID=VSP_041659;Note=In isoform SOFAT. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19877052;Dbxref=PMID:19877052
THNSL2	Q86YJ6	74	139	108	108	Natural variant	ID=VAR_054636;Note=V->I;Dbxref=dbSNP:rs35541720
TRABD2B	A6NFA1	360	449	20	517	Chain	ID=PRO_0000346436;Note=Metalloprotease TIKI2
TRABD2B	A6NFA1	222	271	20	517	Chain	ID=PRO_0000346436;Note=Metalloprotease TIKI2
TRABD2B	A6NFA1	360	449	20	494	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRABD2B	A6NFA1	222	271	20	494	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TRABD2B	A6NFA1	222	271	228	228	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
THOC2	Q8NI27	712	772	1	1593	Chain	ID=PRO_0000072523;Note=THO complex subunit 2
THOC2	Q8NI27	287	339	1	1593	Chain	ID=PRO_0000072523;Note=THO complex subunit 2
THOC2	Q8NI27	712	772	1	1593	Chain	ID=PRO_0000072523;Note=THO complex subunit 2
THOC2	Q8NI27	287	339	1	1593	Chain	ID=PRO_0000072523;Note=THO complex subunit 2
THOC2	Q8NI27	287	339	293	339	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
THOC2	Q8NI27	287	339	293	339	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
THOC2	Q8NI27	712	772	1	1179	Alternative sequence	ID=VSP_008588;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
THOC2	Q8NI27	287	339	1	1179	Alternative sequence	ID=VSP_008588;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
THOC2	Q8NI27	712	772	1	1179	Alternative sequence	ID=VSP_008588;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
THOC2	Q8NI27	287	339	1	1179	Alternative sequence	ID=VSP_008588;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
THOC2	Q8NI27	287	339	313	313	Natural variant	ID=VAR_075718;Note=In MRX12. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26166480;Dbxref=dbSNP:rs797045019,PMID:26166480
THOC2	Q8NI27	287	339	313	313	Natural variant	ID=VAR_075718;Note=In MRX12. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26166480;Dbxref=dbSNP:rs797045019,PMID:26166480
TRAPPC8	Q9Y2L5	1328	1357	1	1435	Chain	ID=PRO_0000065641;Note=Trafficking protein particle complex subunit 8
TRAPPC8	Q9Y2L5	1245	1279	1	1435	Chain	ID=PRO_0000065641;Note=Trafficking protein particle complex subunit 8
TRAPPC8	Q9Y2L5	1187	1245	1	1435	Chain	ID=PRO_0000065641;Note=Trafficking protein particle complex subunit 8
TRAPPC8	Q9Y2L5	576	651	1	1435	Chain	ID=PRO_0000065641;Note=Trafficking protein particle complex subunit 8
TRAPPC8	Q9Y2L5	532	576	1	1435	Chain	ID=PRO_0000065641;Note=Trafficking protein particle complex subunit 8
TRAPPC8	Q9Y2L5	532	576	537	537	Natural variant	ID=VAR_036270;Note=In a breast cancer sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs754569032,PMID:16959974
TRAPPC8	Q9Y2L5	1187	1245	1189	1189	Natural variant	ID=VAR_057816;Note=I->V;Dbxref=dbSNP:rs36034613
TRAPPC8	Q9Y2L5	576	651	631	631	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TPST2	O60704	347	364	1	377	Chain	ID=PRO_0000189829;Note=Protein-tyrosine sulfotransferase 2
TPST2	O60704	347	364	1	377	Chain	ID=PRO_0000189829;Note=Protein-tyrosine sulfotransferase 2
TPST2	O60704	347	364	1	377	Chain	ID=PRO_0000189829;Note=Protein-tyrosine sulfotransferase 2
TPST2	O60704	347	364	26	377	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPST2	O60704	347	364	26	377	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPST2	O60704	347	364	26	377	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TPST2	O60704	347	364	339	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AP1
TPST2	O60704	347	364	339	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AP1
TPST2	O60704	347	364	339	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AP1
TSG101	Q99816	42	64	2	390	Chain	ID=PRO_0000082606;Note=Tumor susceptibility gene 101 protein
TSG101	Q99816	42	64	2	145	Domain	Note=UEV;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00652
TSG101	Q99816	42	64	15	119	Alternative sequence	ID=VSP_004440;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TSG101	Q99816	42	64	43	43	Mutagenesis	Note=Reduces interaction with ubiquitin%3B inhibits down-regulation of EGFR. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492
TSG101	Q99816	42	64	45	45	Mutagenesis	Note=Reduces interaction with ubiquitin. No effect on MGRN1-binding. N->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12006492,ECO:0000269|PubMed:12802020,ECO:0000269|PubMed:17229889;Dbxref=PMID:12006492,PMID:12802020,PMID:17229889
TSG101	Q99816	42	64	46	46	Mutagenesis	Note=Reduces interaction with ubiquitin. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492
TSG101	Q99816	42	64	63	63	Mutagenesis	Note=Reduces interaction with HIV-1 p6%3B impairs HIV-1 budding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492
TSG101	Q99816	42	64	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OBQ
TSG101	Q99816	42	64	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P9G
TSG101	Q99816	42	64	51	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OBQ
TSPAN2	O60636	172	200	1	221	Chain	ID=PRO_0000219236;Note=Tetraspanin-2
TSPAN2	O60636	90	115	1	221	Chain	ID=PRO_0000219236;Note=Tetraspanin-2
TSPAN2	O60636	90	115	76	90	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN2	O60636	90	115	91	111	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN2	O60636	172	200	112	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN2	O60636	90	115	112	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN2	O60636	172	200	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN2	O60636	172	200	173	200	Alternative sequence	ID=VSP_047734;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
TTC17	Q96AE7	53	83	1	1141	Chain	ID=PRO_0000106406;Note=Tetratricopeptide repeat protein 17
TSPAN8	P19075	192	220	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	148	192	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	112	148	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	41	87	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	20	41	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	192	220	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	148	192	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	112	148	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	41	87	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	20	41	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	192	220	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	148	192	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	112	148	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	41	87	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	20	41	1	237	Chain	ID=PRO_0000219252;Note=Tetraspanin-8
TSPAN8	P19075	20	41	10	33	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	20	41	10	33	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	20	41	10	33	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	34	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	20	41	34	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	34	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	20	41	34	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	34	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	20	41	34	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	58	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	58	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	58	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	73	83	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	73	83	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	73	83	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	84	109	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	84	109	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	41	87	84	109	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	192	220	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	148	192	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	112	148	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	192	220	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	148	192	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	112	148	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	192	220	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	148	192	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	112	148	110	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	192	220	206	230	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	192	220	206	230	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	192	220	206	230	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TSPAN8	P19075	112	148	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
TSPAN8	P19075	112	148	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
TSPAN8	P19075	112	148	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
TSPAN8	P19075	20	41	35	35	Natural variant	ID=VAR_061848;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17849952,PMID:15489334
TSPAN8	P19075	20	41	35	35	Natural variant	ID=VAR_061848;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17849952,PMID:15489334
TSPAN8	P19075	20	41	35	35	Natural variant	ID=VAR_061848;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17849952,PMID:15489334
TSPAN8	P19075	41	87	73	73	Natural variant	ID=VAR_020093;Note=G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3763978,PMID:15489334
TSPAN8	P19075	41	87	73	73	Natural variant	ID=VAR_020093;Note=G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3763978,PMID:15489334
TSPAN8	P19075	41	87	73	73	Natural variant	ID=VAR_020093;Note=G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3763978,PMID:15489334
TSPAN8	P19075	192	220	213	213	Natural variant	ID=VAR_012054;Note=S->A;Dbxref=dbSNP:rs1051334
TSPAN8	P19075	192	220	213	213	Natural variant	ID=VAR_012054;Note=S->A;Dbxref=dbSNP:rs1051334
TSPAN8	P19075	192	220	213	213	Natural variant	ID=VAR_012054;Note=S->A;Dbxref=dbSNP:rs1051334
TSR2	Q969E8	88	147	1	190	Chain	ID=PRO_0000285587;Note=Pre-rRNA-processing protein TSR2 homolog
TTLL11	Q8NHH1	321	513	1	800	Chain	ID=PRO_0000212445;Note=Tubulin polyglutamylase TTLL11
TTLL11	Q8NHH1	321	513	218	570	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL11	Q8NHH1	321	513	372	375	Nucleotide binding	Note=ATP binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZT98
TTLL11	Q8NHH1	321	513	385	385	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZT98
TTLL11	Q8NHH1	321	513	387	387	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZT98
TRIM28	Q13263	318	367	2	835	Chain	ID=PRO_0000056392;Note=Transcription intermediary factor 1-beta
TRIM28	Q13263	318	367	65	376	Region	Note=RBCC domain
TRIM28	Q13263	318	367	246	376	Region	Note=Leucine zipper alpha helical coiled-coil region
TRIM28	Q13263	318	367	247	376	Region	Note=Interaction with MAGEC2
TRIM28	Q13263	318	367	366	370	Region	Note=Involved in binding PPP1CA
TRIM28	Q13263	318	367	340	340	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TRIM28	Q13263	318	367	319	319	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
TRIM28	Q13263	318	367	366	366	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
TRIM28	Q13263	318	367	366	366	Mutagenesis	Note=Greatly reduced interaction with PPP1CA. K->G
TLDC2	A0PJX2	114	146	1	215	Chain	ID=PRO_0000318690;Note=TLD domain-containing protein 2
TLDC2	A0PJX2	114	146	1	215	Chain	ID=PRO_0000318690;Note=TLD domain-containing protein 2
TLDC2	A0PJX2	114	146	79	215	Domain	Note=TLD
TLDC2	A0PJX2	114	146	79	215	Domain	Note=TLD
TPRG1	Q6ZUI0	101	159	1	275	Chain	ID=PRO_0000268825;Note=Tumor protein p63-regulated gene 1 protein
TPRG1	Q6ZUI0	101	159	1	275	Chain	ID=PRO_0000268825;Note=Tumor protein p63-regulated gene 1 protein
TPRG1	Q6ZUI0	101	159	68	240	Domain	Note=hSac2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01127
TPRG1	Q6ZUI0	101	159	68	240	Domain	Note=hSac2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01127
TPR	P12270	2313	2345	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	2189	2221	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1963	2007	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1868	1896	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1250	1296	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1250	1296	1218	1320	Region	Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941
TPR	P12270	1250	1296	1215	1630	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TPR	P12270	1963	2007	1971	1978	Compositional bias	Note=Poly-Asp
TPR	P12270	1868	1896	1893	1893	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TPR	P12270	2313	2345	2343	2343	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4
TPR	P12270	2313	2345	2345	2345	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4
TPR	P12270	2313	2345	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	2189	2221	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1963	2007	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1868	1896	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1250	1296	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1963	2007	1952	1965	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
MID2	Q9UJV3	240	272	1	735	Chain	ID=PRO_0000056193;Note=Probable E3 ubiquitin-protein ligase MID2
MID2	Q9UJV3	400	478	1	735	Chain	ID=PRO_0000056193;Note=Probable E3 ubiquitin-protein ligase MID2
MID2	Q9UJV3	400	478	398	531	Domain	Note=Fibronectin type-III
MID2	Q9UJV3	240	272	233	301	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MID2	Q9UJV3	400	478	450	479	Alternative sequence	ID=VSP_009009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10644436,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:10644436,PMID:15489334
MID2	Q9UJV3	400	478	406	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMK
MID2	Q9UJV3	400	478	418	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMK
MID2	Q9UJV3	400	478	429	442	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMK
TRMT2A	Q8IZ69	477	516	1	625	Chain	ID=PRO_0000081614;Note=tRNA (uracil-5-)-methyltransferase homolog A
TRMT2A	Q8IZ69	411	452	1	625	Chain	ID=PRO_0000081614;Note=tRNA (uracil-5-)-methyltransferase homolog A
TRMT2A	Q8IZ69	477	516	1	625	Chain	ID=PRO_0000081614;Note=tRNA (uracil-5-)-methyltransferase homolog A
TRMT2A	Q8IZ69	411	452	1	625	Chain	ID=PRO_0000081614;Note=tRNA (uracil-5-)-methyltransferase homolog A
TRMT2A	Q8IZ69	411	452	411	411	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01024
TRMT2A	Q8IZ69	411	452	411	411	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01024
TRMT2A	Q8IZ69	477	516	510	510	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01024
TRMT2A	Q8IZ69	477	516	510	510	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01024
TRMT2A	Q8IZ69	477	516	498	498	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRMT2A	Q8IZ69	477	516	498	498	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNRNP48	Q6IEG0	135	198	1	339	Chain	ID=PRO_0000089544;Note=U11/U12 small nuclear ribonucleoprotein 48 kDa protein
SNRNP48	Q6IEG0	135	198	136	144	Alternative sequence	ID=VSP_014640;Note=In isoform 2. RIYSSLPVE->IIGVSIKRN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SNRNP48	Q6IEG0	135	198	145	336	Alternative sequence	ID=VSP_014641;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PSG4	Q00888	236	329	35	419	Chain	ID=PRO_0000014911;Note=Pregnancy-specific beta-1-glycoprotein 4
PSG4	Q00888	143	236	35	419	Chain	ID=PRO_0000014911;Note=Pregnancy-specific beta-1-glycoprotein 4
PSG4	Q00888	143	236	35	144	Domain	Note=Ig-like V-type
PSG4	Q00888	143	236	147	234	Domain	Note=Ig-like C2-type 1
PSG4	Q00888	236	329	237	327	Domain	Note=Ig-like C2-type 2
PSG4	Q00888	143	236	199	199	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG4	Q00888	236	329	268	268	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG4	Q00888	236	329	299	299	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG4	Q00888	236	329	303	303	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG4	Q00888	143	236	169	217	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG4	Q00888	236	329	262	310	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG4	Q00888	236	329	144	236	Alternative sequence	ID=VSP_055025;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG4	Q00888	143	236	144	236	Alternative sequence	ID=VSP_055025;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG4	Q00888	236	329	237	329	Alternative sequence	ID=VSP_007875;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7794280;Dbxref=PMID:7794280
PSG4	Q00888	143	236	177	177	Natural variant	ID=VAR_060363;Note=S->R;Dbxref=dbSNP:rs73548061
PSG4	Q00888	236	329	240	240	Natural variant	ID=VAR_056073;Note=S->P;Dbxref=dbSNP:rs3859474
PSG4	Q00888	236	329	267	267	Natural variant	ID=VAR_060364;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1922019,ECO:0000269|PubMed:2271648,ECO:0000269|PubMed:2783133,ECO:0000269|PubMed:7794280;Dbxref=dbSNP:rs1058718,PMID:1922019,PMID:2271648,PMID:2783133,PMID:7794280
PSG4	Q00888	236	329	286	286	Natural variant	ID=VAR_056074;Note=V->A;Dbxref=dbSNP:rs2355442
PSG4	Q00888	143	236	175	175	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG8	Q9UQ74	21	143	1	34	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG8	Q9UQ74	21	143	35	426	Chain	ID=PRO_0000014915;Note=Pregnancy-specific beta-1-glycoprotein 8
PSG8	Q9UQ74	21	143	35	144	Domain	Note=Ig-like V-type
PSG8	Q9UQ74	21	143	61	61	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG8	Q9UQ74	21	143	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG8	Q9UQ74	21	143	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG8	Q9UQ74	21	143	22	144	Alternative sequence	ID=VSP_041096;Note=In isoform 2. ASLLNFWNPPTTAQVTIEAQPTKVSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETIYSNASLLIQNVTQEDAGSYTLHIIMGGDENRGVTGHFTFTLYL->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PSG8	Q9UQ74	21	143	79	79	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG9	Q00887	236	329	35	426	Chain	ID=PRO_0000014916;Note=Pregnancy-specific beta-1-glycoprotein 9
PSG9	Q00887	236	329	242	326	Domain	Note=Ig-like C2-type 2
PSG9	Q00887	236	329	268	268	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG9	Q00887	236	329	303	303	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSG9	Q00887	236	329	262	310	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
PSG9	Q00887	236	329	237	330	Alternative sequence	ID=VSP_055602;Note=In isoform 2. PKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIRDRYGGLRSNPVILNVLY->H;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1922019;Dbxref=PMID:1922019
PSG9	Q00887	236	329	325	325	Natural variant	ID=VAR_049925;Note=I->T;Dbxref=dbSNP:rs1135905
PSG9	Q00887	236	329	313	313	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	881	926	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	779	794	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	663	752	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	384	473	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	295	384	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	295	384	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	206	295	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	206	295	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	206	295	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	117	206	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	117	206	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	117	206	28	1115	Chain	ID=PRO_0000318950;Note=Receptor-type tyrosine-protein phosphatase H
PTPRH	Q9HD43	663	752	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	384	473	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	295	384	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	295	384	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	117	206	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	117	206	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	117	206	28	754	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	881	926	776	1115	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	779	794	776	1115	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	117	206	32	121	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	117	206	32	121	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	117	206	32	121	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	206	295	122	209	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	206	295	122	209	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	206	295	122	209	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	117	206	122	209	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	117	206	122	209	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	117	206	122	209	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	295	384	210	299	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	295	384	210	299	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	206	295	210	299	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	206	295	210	299	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	206	295	210	299	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	384	473	300	387	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	295	384	300	387	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	295	384	300	387	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	384	473	388	477	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	663	752	564	666	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	663	752	665	749	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRH	Q9HD43	881	926	820	1079	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRH	Q9HD43	117	206	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	117	206	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	117	206	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	256	256	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	256	256	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	256	256	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	295	384	350	350	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	295	384	350	350	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	384	473	434	434	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	384	473	468	468	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRH	Q9HD43	206	295	84	261	Alternative sequence	ID=VSP_031318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRH	Q9HD43	206	295	84	261	Alternative sequence	ID=VSP_031318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRH	Q9HD43	206	295	84	261	Alternative sequence	ID=VSP_031318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRH	Q9HD43	117	206	84	261	Alternative sequence	ID=VSP_031318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRH	Q9HD43	117	206	84	261	Alternative sequence	ID=VSP_031318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRH	Q9HD43	117	206	84	261	Alternative sequence	ID=VSP_031318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRH	Q9HD43	295	384	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	295	384	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	206	295	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	206	295	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	206	295	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	117	206	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	117	206	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	117	206	126	303	Alternative sequence	ID=VSP_054222;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	206	295	232	232	Natural variant	ID=VAR_061762;Note=D->N;Dbxref=dbSNP:rs55870162
PTPRH	Q9HD43	206	295	232	232	Natural variant	ID=VAR_061762;Note=D->N;Dbxref=dbSNP:rs55870162
PTPRH	Q9HD43	206	295	232	232	Natural variant	ID=VAR_061762;Note=D->N;Dbxref=dbSNP:rs55870162
PTPRH	Q9HD43	206	295	243	243	Natural variant	ID=VAR_061763;Note=V->I;Dbxref=dbSNP:rs45535035
PTPRH	Q9HD43	206	295	243	243	Natural variant	ID=VAR_061763;Note=V->I;Dbxref=dbSNP:rs45535035
PTPRH	Q9HD43	206	295	243	243	Natural variant	ID=VAR_061763;Note=V->I;Dbxref=dbSNP:rs45535035
PTPRH	Q9HD43	295	384	348	348	Natural variant	ID=VAR_038918;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2288515,PMID:15489334
PTPRH	Q9HD43	295	384	348	348	Natural variant	ID=VAR_038918;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2288515,PMID:15489334
PTPRH	Q9HD43	779	794	781	781	Natural variant	ID=VAR_038920;Note=K->N;Dbxref=dbSNP:rs2288523
PTPRH	Q9HD43	206	295	294	294	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	206	295	294	294	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	206	295	294	294	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRH	Q9HD43	384	473	422	422	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRJ	Q12913	38	117	36	1337	Chain	ID=PRO_0000025444;Note=Receptor-type tyrosine-protein phosphatase eta
PTPRJ	Q12913	117	205	36	1337	Chain	ID=PRO_0000025444;Note=Receptor-type tyrosine-protein phosphatase eta
PTPRJ	Q12913	38	117	36	975	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	117	205	36	975	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	117	205	121	209	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
PTPRJ	Q12913	38	117	72	72	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	38	117	82	82	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	38	117	93	93	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	38	117	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	117	205	142	142	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	117	205	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRJ	Q12913	117	205	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	892	909	35	979	Chain	ID=PRO_0000025451;Note=Receptor-type tyrosine-protein phosphatase-like N
PTPRN	Q16849	770	796	35	979	Chain	ID=PRO_0000025451;Note=Receptor-type tyrosine-protein phosphatase-like N
PTPRN	Q16849	556	629	35	979	Chain	ID=PRO_0000025451;Note=Receptor-type tyrosine-protein phosphatase-like N
PTPRN	Q16849	479	507	35	979	Chain	ID=PRO_0000025451;Note=Receptor-type tyrosine-protein phosphatase-like N
PTPRN	Q16849	55	93	35	979	Chain	ID=PRO_0000025451;Note=Receptor-type tyrosine-protein phosphatase-like N
PTPRN	Q16849	38	55	35	979	Chain	ID=PRO_0000025451;Note=Receptor-type tyrosine-protein phosphatase-like N
PTPRN	Q16849	55	93	35	448	Chain	ID=PRO_0000438079;Note=ICA512-N-terminal fragment;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P56722,ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	38	55	35	448	Chain	ID=PRO_0000438079;Note=ICA512-N-terminal fragment;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P56722,ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	892	909	449	979	Chain	ID=PRO_0000438080;Note=ICA512-transmembrane fragment;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P56722,ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	770	796	449	979	Chain	ID=PRO_0000438080;Note=ICA512-transmembrane fragment;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P56722,ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	556	629	449	979	Chain	ID=PRO_0000438080;Note=ICA512-transmembrane fragment;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P56722,ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	479	507	449	979	Chain	ID=PRO_0000438080;Note=ICA512-transmembrane fragment;Ontology_term=ECO:0000250,ECO:0000305;evidence=ECO:0000250|UniProtKB:P56722,ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	892	909	659	979	Chain	ID=PRO_0000438081;Note=ICA512-cleaved cytosolic fragment;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:15596545,ECO:0000305|PubMed:26836020;Dbxref=PMID:15596545,PMID:26836020
PTPRN	Q16849	770	796	659	979	Chain	ID=PRO_0000438081;Note=ICA512-cleaved cytosolic fragment;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:15596545,ECO:0000305|PubMed:26836020;Dbxref=PMID:15596545,PMID:26836020
PTPRN	Q16849	556	629	35	575	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	479	507	35	575	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	55	93	35	575	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	38	55	35	575	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	556	629	576	600	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	892	909	601	979	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	770	796	601	979	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	556	629	601	979	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRN	Q16849	892	909	709	969	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRN	Q16849	770	796	709	969	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRN	Q16849	55	93	35	131	Region	Note=RESP18 homology domain
PTPRN	Q16849	38	55	35	131	Region	Note=RESP18 homology domain
PTPRN	Q16849	556	629	449	575	Region	Note=Sufficient for dimerization of proICA512;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25561468;Dbxref=PMID:25561468
PTPRN	Q16849	479	507	449	575	Region	Note=Sufficient for dimerization of proICA512;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25561468;Dbxref=PMID:25561468
PTPRN	Q16849	556	629	601	732	Region	Note=Sufficient for dimerization of proICA512;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80560
PTPRN	Q16849	479	507	506	506	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:25561468;Dbxref=PMID:25561468
PTPRN	Q16849	38	55	40	40	Disulfide bond	Note=Interchain (with C-40 or C-47)%3B in multimeric form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	38	55	47	47	Disulfide bond	Note=Interchain (with C-40 or C-47)%3B in multimeric form;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	55	93	53	62	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	38	55	53	62	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26836020;Dbxref=PMID:26836020
PTPRN	Q16849	55	93	1	90	Alternative sequence	ID=VSP_045867;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTPRN	Q16849	38	55	1	90	Alternative sequence	ID=VSP_045867;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTPRN	Q16849	479	507	479	508	Alternative sequence	ID=VSP_043654;Note=In isoform 2. KPLSLAAGVKLLEILAEHVHMSSGSFINIS->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PTPRN	Q16849	479	507	506	506	Mutagenesis	Note=Reduces N-glycosylation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25561468;Dbxref=PMID:25561468
PTPRN	Q16849	479	507	483	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT7
PTPRN	Q16849	479	507	501	503	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT7
PTPRN	Q16849	479	507	504	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QT7
PTPRN	Q16849	770	796	766	770	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1Y
PTPRN	Q16849	770	796	780	783	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1Y
PTPRN	Q16849	770	796	788	790	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1Y
PTPRN	Q16849	770	796	791	801	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1Y
PTPRN	Q16849	892	909	885	896	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1Y
PTPRN	Q16849	892	909	905	908	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1Y
CAD	P27708	614	677	2	2225	Chain	ID=PRO_0000199506;Note=CAD protein
CAD	P27708	1072	1133	2	2225	Chain	ID=PRO_0000199506;Note=CAD protein
CAD	P27708	1262	1323	2	2225	Chain	ID=PRO_0000199506;Note=CAD protein
CAD	P27708	1751	1798	2	2225	Chain	ID=PRO_0000199506;Note=CAD protein
CAD	P27708	1798	1832	2	2225	Chain	ID=PRO_0000199506;Note=CAD protein
CAD	P27708	614	677	519	711	Domain	Note=ATP-grasp 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
CAD	P27708	1072	1133	1052	1243	Domain	Note=ATP-grasp 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
CAD	P27708	1262	1323	1308	1462	Domain	Note=MGS-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01202
CAD	P27708	1072	1133	1078	1135	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
CAD	P27708	614	677	395	1455	Region	Note=CPSase (Carbamoyl-phosphate synthase);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1072	1133	395	1455	Region	Note=CPSase (Carbamoyl-phosphate synthase);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1262	1323	395	1455	Region	Note=CPSase (Carbamoyl-phosphate synthase);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	614	677	395	933	Region	Note=CPSase A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1072	1133	934	1455	Region	Note=CPSase B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1262	1323	934	1455	Region	Note=CPSase B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1751	1798	1456	1788	Region	Note=DHOase (dihydroorotase);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1751	1798	1789	1917	Region	Note=Linker;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	1798	1832	1789	1917	Region	Note=Linker;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08955
CAD	P27708	614	677	668	668	Metal binding	Note=Magnesium or manganese 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00409
CAD	P27708	1751	1798	1789	2225	Natural variant	ID=VAR_078290;Note=In EIEE50%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28087732;Dbxref=PMID:28087732
CAD	P27708	1798	1832	1789	2225	Natural variant	ID=VAR_078290;Note=In EIEE50%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28087732;Dbxref=PMID:28087732
CAD	P27708	1072	1133	1103	1103	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAD	P27708	1751	1798	1749	1759	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C6F
CAD	P27708	1751	1798	1773	1776	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C6F
CAD	P27708	1751	1798	1778	1788	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C6F
CAD	P27708	1751	1798	1791	1795	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C6F
CAD	P27708	1798	1832	1809	1811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C6F
CAD	P27708	1798	1832	1813	1815	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C6F
RAB3IL1	Q8TBN0	146	219	1	382	Chain	ID=PRO_0000305295;Note=Guanine nucleotide exchange factor for Rab-3A
RAB3IL1	Q8TBN0	146	219	73	161	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RAB3IL1	Q8TBN0	146	219	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
RAB3IL1	Q8TBN0	146	219	179	179	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RAB3IL1	Q8TBN0	146	219	147	219	Alternative sequence	ID=VSP_028345;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RAB3IL1	Q8TBN0	146	219	80	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LI0
R3HDM1	Q15032	57	71	1	1099	Chain	ID=PRO_0000097139;Note=R3H domain-containing protein 1
R3HDM1	Q15032	166	185	1	1099	Chain	ID=PRO_0000097139;Note=R3H domain-containing protein 1
R3HDM1	Q15032	406	491	1	1099	Chain	ID=PRO_0000097139;Note=R3H domain-containing protein 1
R3HDM1	Q15032	541	641	1	1099	Chain	ID=PRO_0000097139;Note=R3H domain-containing protein 1
R3HDM1	Q15032	166	185	168	231	Domain	Note=R3H;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00382
R3HDM1	Q15032	541	641	589	608	Compositional bias	Note=Poly-Pro
R3HDM1	Q15032	57	71	45	100	Alternative sequence	ID=VSP_054309;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
R3HDM1	Q15032	57	71	57	100	Alternative sequence	ID=VSP_017344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7584026;Dbxref=PMID:7584026
R3HDM1	Q15032	406	491	406	490	Alternative sequence	ID=VSP_017345;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7584026;Dbxref=PMID:7584026
R3HDM1	Q15032	541	641	541	541	Alternative sequence	ID=VSP_054310;Note=In isoform 2%2C isoform 3 and isoform 4. Q->QQ;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7584026;Dbxref=PMID:14702039,PMID:15489334,PMID:7584026
R3HDM1	Q15032	541	641	632	632	Natural variant	ID=VAR_025424;Note=Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2305165,PMID:14702039
R3HDM2	Q9Y2K5	281	298	1	976	Chain	ID=PRO_0000050787;Note=R3H domain-containing protein 2
R3HDM2	Q9Y2K5	55	69	1	976	Chain	ID=PRO_0000050787;Note=R3H domain-containing protein 2
R3HDM2	Q9Y2K5	281	298	1	976	Chain	ID=PRO_0000050787;Note=R3H domain-containing protein 2
R3HDM2	Q9Y2K5	55	69	1	976	Chain	ID=PRO_0000050787;Note=R3H domain-containing protein 2
R3HDM2	Q9Y2K5	281	298	233	310	Domain	Note=SUZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01009
R3HDM2	Q9Y2K5	281	298	233	310	Domain	Note=SUZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01009
R3HDM2	Q9Y2K5	281	298	288	369	Compositional bias	Note=Ser-rich
R3HDM2	Q9Y2K5	281	298	288	369	Compositional bias	Note=Ser-rich
R3HDM2	Q9Y2K5	281	298	1	339	Alternative sequence	ID=VSP_057391;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	55	69	1	339	Alternative sequence	ID=VSP_057391;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	281	298	1	339	Alternative sequence	ID=VSP_057391;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	55	69	1	339	Alternative sequence	ID=VSP_057391;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	281	298	1	295	Alternative sequence	ID=VSP_026087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	55	69	1	295	Alternative sequence	ID=VSP_026087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	281	298	1	295	Alternative sequence	ID=VSP_026087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	55	69	1	295	Alternative sequence	ID=VSP_026087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	281	298	296	298	Alternative sequence	ID=VSP_026088;Note=In isoform 2. QIF->MIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
R3HDM2	Q9Y2K5	281	298	296	298	Alternative sequence	ID=VSP_026088;Note=In isoform 2. QIF->MIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RABEP1	Q15276	133	173	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	278	322	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	478	513	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	513	552	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	552	585	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	585	632	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	714	747	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	747	786	2	862	Chain	ID=PRO_0000187556;Note=Rab GTPase-binding effector protein 1
RABEP1	Q15276	133	173	11	345	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	278	322	11	345	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	513	552	534	816	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	552	585	534	816	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	585	632	534	816	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	714	747	534	816	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	747	786	534	816	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP1	Q15276	278	322	282	282	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RABEP1	Q15276	747	786	758	790	Alternative sequence	ID=VSP_010451;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10698684;Dbxref=PMID:10698684
RABEP1	Q15276	133	173	149	149	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
RABEP1	Q15276	133	173	149	149	Sequence conflict	Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
RABEP1	Q15276	585	632	628	628	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
RABEP1	Q15276	552	585	553	633	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N3Y
RABEP1	Q15276	585	632	553	633	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N3Y
RABEP2	Q9H5N1	497	536	2	569	Chain	ID=PRO_0000187559;Note=Rab GTPase-binding effector protein 2
RABEP2	Q9H5N1	363	415	2	569	Chain	ID=PRO_0000187559;Note=Rab GTPase-binding effector protein 2
RABEP2	Q9H5N1	298	330	2	569	Chain	ID=PRO_0000187559;Note=Rab GTPase-binding effector protein 2
RABEP2	Q9H5N1	20	91	2	569	Chain	ID=PRO_0000187559;Note=Rab GTPase-binding effector protein 2
RABEP2	Q9H5N1	20	91	34	187	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP2	Q9H5N1	497	536	289	523	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP2	Q9H5N1	363	415	289	523	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP2	Q9H5N1	298	330	289	523	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RABEP2	Q9H5N1	298	330	299	330	Alternative sequence	ID=VSP_010458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ADSS	P30520	158	193	1	456	Chain	ID=PRO_0000095130;Note=Adenylosuccinate synthetase isozyme 2
ADSS	P30520	118	135	1	456	Chain	ID=PRO_0000095130;Note=Adenylosuccinate synthetase isozyme 2
ADSS	P30520	158	193	162	162	Binding site	Note=IMP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03127
ADSS	P30520	158	193	176	176	Binding site	Note=IMP%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03127
ADSS	P30520	158	193	179	179	Natural variant	ID=VAR_051881;Note=L->F;Dbxref=dbSNP:rs12134870
ADSS	P30520	118	135	118	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
ADSS	P30520	118	135	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
ADSS	P30520	118	135	126	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
ADSS	P30520	118	135	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
ADSS	P30520	158	193	166	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
ADSS	P30520	158	193	181	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
ADSS	P30520	158	193	188	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V40
PLXDC2	Q6UX71	108	157	31	529	Chain	ID=PRO_0000234574;Note=Plexin domain-containing protein 2
PLXDC2	Q6UX71	180	221	31	529	Chain	ID=PRO_0000234574;Note=Plexin domain-containing protein 2
PLXDC2	Q6UX71	424	437	31	529	Chain	ID=PRO_0000234574;Note=Plexin domain-containing protein 2
PLXDC2	Q6UX71	108	157	31	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXDC2	Q6UX71	180	221	31	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXDC2	Q6UX71	424	437	31	454	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXDC2	Q6UX71	424	437	383	427	Compositional bias	Note=Thr-rich
PLXDC2	Q6UX71	108	157	1	378	Alternative sequence	ID=VSP_018377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLXDC2	Q6UX71	180	221	1	378	Alternative sequence	ID=VSP_018377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PLXDC2	Q6UX71	108	157	109	157	Alternative sequence	ID=VSP_018378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PXDNL	A1KZ92	1186	1230	24	1463	Chain	ID=PRO_0000330731;Note=Peroxidasin-like protein
PXDNL	A1KZ92	455	508	24	1463	Chain	ID=PRO_0000330731;Note=Peroxidasin-like protein
PXDNL	A1KZ92	151	174	24	1463	Chain	ID=PRO_0000330731;Note=Peroxidasin-like protein
PXDNL	A1KZ92	103	126	24	1463	Chain	ID=PRO_0000330731;Note=Peroxidasin-like protein
PXDNL	A1KZ92	79	102	24	1463	Chain	ID=PRO_0000330731;Note=Peroxidasin-like protein
PXDNL	A1KZ92	79	102	75	96	Repeat	Note=LRR 2
PXDNL	A1KZ92	103	126	99	120	Repeat	Note=LRR 3
PXDNL	A1KZ92	79	102	99	120	Repeat	Note=LRR 3
PXDNL	A1KZ92	103	126	123	144	Repeat	Note=LRR 4
PXDNL	A1KZ92	151	174	147	168	Repeat	Note=LRR 5
PXDNL	A1KZ92	455	508	419	504	Domain	Note=Ig-like C2-type 3
PXDNL	A1KZ92	455	508	507	596	Domain	Note=Ig-like C2-type 4
PXDNL	A1KZ92	455	508	440	488	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PXDNL	A1KZ92	1186	1230	1160	1217	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PXDNL	A1KZ92	455	508	1	801	Alternative sequence	ID=VSP_044240;Note=In isoform PMR1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PXDNL	A1KZ92	151	174	1	801	Alternative sequence	ID=VSP_044240;Note=In isoform PMR1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PXDNL	A1KZ92	103	126	1	801	Alternative sequence	ID=VSP_044240;Note=In isoform PMR1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PXDNL	A1KZ92	79	102	1	801	Alternative sequence	ID=VSP_044240;Note=In isoform PMR1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RABL3	Q5HYI8	202	215	1	236	Chain	ID=PRO_0000312166;Note=Rab-like protein 3
RABL3	Q5HYI8	178	202	1	236	Chain	ID=PRO_0000312166;Note=Rab-like protein 3
RABL3	Q5HYI8	202	215	1	236	Region	Note=Small GTPase-like
RABL3	Q5HYI8	178	202	1	236	Region	Note=Small GTPase-like
RAD52	P43351	288	322	1	418	Chain	ID=PRO_0000173881;Note=DNA repair protein RAD52 homolog
RAD52	P43351	28	62	1	418	Chain	ID=PRO_0000173881;Note=DNA repair protein RAD52 homolog
RAD52	P43351	288	322	1	418	Chain	ID=PRO_0000173881;Note=DNA repair protein RAD52 homolog
RAD52	P43351	28	62	1	418	Chain	ID=PRO_0000173881;Note=DNA repair protein RAD52 homolog
RAD52	P43351	288	322	318	318	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
RAD52	P43351	288	322	318	318	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
RAD52	P43351	288	322	119	418	Alternative sequence	ID=VSP_047751;Note=In isoform delta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10673031,ECO:0000303|PubMed:14702039;Dbxref=PMID:10673031,PMID:14702039
RAD52	P43351	288	322	119	418	Alternative sequence	ID=VSP_047751;Note=In isoform delta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10673031,ECO:0000303|PubMed:14702039;Dbxref=PMID:10673031,PMID:14702039
RAD52	P43351	288	322	140	418	Alternative sequence	ID=VSP_047752;Note=In isoform gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10673031,ECO:0000303|PubMed:14702039;Dbxref=PMID:10673031,PMID:14702039
RAD52	P43351	288	322	140	418	Alternative sequence	ID=VSP_047752;Note=In isoform gamma. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10673031,ECO:0000303|PubMed:14702039;Dbxref=PMID:10673031,PMID:14702039
RAD52	P43351	288	322	227	418	Alternative sequence	ID=VSP_047754;Note=In isoform beta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10673031;Dbxref=PMID:10673031
RAD52	P43351	288	322	227	418	Alternative sequence	ID=VSP_047754;Note=In isoform beta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10673031;Dbxref=PMID:10673031
RAD52	P43351	28	62	55	55	Mutagenesis	Note=Abolishes ssDNA-binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12191481;Dbxref=PMID:12191481
RAD52	P43351	28	62	55	55	Mutagenesis	Note=Abolishes ssDNA-binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12191481;Dbxref=PMID:12191481
RAD52	P43351	28	62	26	28	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KN0
RAD52	P43351	28	62	26	28	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KN0
RAD52	P43351	28	62	33	43	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	33	43	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	49	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	49	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	52	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	52	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	60	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
RAD52	P43351	28	62	60	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JRB
ATIC	P31939	229	271	1	592	Chain	ID=PRO_0000192156;Note=Bifunctional purine biosynthesis protein PURH
ATIC	P31939	366	409	1	592	Chain	ID=PRO_0000192156;Note=Bifunctional purine biosynthesis protein PURH
ATIC	P31939	440	501	1	592	Chain	ID=PRO_0000192156;Note=Bifunctional purine biosynthesis protein PURH
ATIC	P31939	229	271	2	592	Chain	ID=PRO_0000434376;Note=Bifunctional purine biosynthesis protein PURH%2C N-terminally processed
ATIC	P31939	366	409	2	592	Chain	ID=PRO_0000434376;Note=Bifunctional purine biosynthesis protein PURH%2C N-terminally processed
ATIC	P31939	440	501	2	592	Chain	ID=PRO_0000434376;Note=Bifunctional purine biosynthesis protein PURH%2C N-terminally processed
ATIC	P31939	229	271	267	267	Active site	Note=Proton acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATIC	P31939	440	501	451	451	Binding site	Note=AICAR%3B shared with dimeric partner;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14966129;Dbxref=PMID:14966129
ATIC	P31939	229	271	266	266	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATIC	P31939	229	271	227	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	229	271	237	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	229	271	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	229	271	269	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	366	409	363	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	366	409	375	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	366	409	384	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	366	409	397	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	440	501	440	445	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	440	501	451	467	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	440	501	471	474	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
ATIC	P31939	440	501	484	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZ0
PUS10	Q3MIT2	42	127	1	529	Chain	ID=PRO_0000299022;Note=Putative tRNA pseudouridine synthase Pus10
PUS10	Q3MIT2	42	127	1	529	Chain	ID=PRO_0000299022;Note=Putative tRNA pseudouridine synthase Pus10
PUS10	Q3MIT2	42	127	42	89	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PUS10	Q3MIT2	42	127	42	89	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
PUS10	Q3MIT2	42	127	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
PUS10	Q3MIT2	42	127	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
PUS10	Q3MIT2	42	127	84	84	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
PUS10	Q3MIT2	42	127	84	84	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
PUS10	Q3MIT2	42	127	41	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	41	52	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	110	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	110	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	118	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	118	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	122	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS10	Q3MIT2	42	127	122	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V9K
PUS7	Q96PZ0	508	542	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	307	349	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	508	542	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	307	349	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	508	542	370	580	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7	Q96PZ0	508	542	370	580	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7	Q96PZ0	307	349	310	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	310	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	316	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	316	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	321	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	321	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	342	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	342	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	510	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	510	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	516	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	516	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	519	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	519	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	524	526	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	524	526	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	527	531	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	527	531	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	533	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	533	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
DHODH	Q02127	7	78	1	395	Chain	ID=PRO_0000029884;Note=Dihydroorotate dehydrogenase (quinone)%2C mitochondrial
DHODH	Q02127	235	273	1	395	Chain	ID=PRO_0000029884;Note=Dihydroorotate dehydrogenase (quinone)%2C mitochondrial
DHODH	Q02127	7	78	1	10	Transit peptide	Note=Mitochondrion%3B not cleaved;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHODH	Q02127	7	78	1	10	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHODH	Q02127	7	78	11	30	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHODH	Q02127	7	78	31	395	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHODH	Q02127	235	273	31	395	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHODH	Q02127	235	273	254	254	Binding site	Note=FMN;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10673429,ECO:0000269|PubMed:16480261;Dbxref=PMID:10673429,PMID:16480261
DHODH	Q02127	7	78	7	7	Natural variant	ID=VAR_022094;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1446837,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3213422,PMID:1446837,PMID:14702039
DHODH	Q02127	7	78	19	19	Natural variant	ID=VAR_062412;Note=In POADS. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19915526;Dbxref=dbSNP:rs267606765,PMID:19915526
DHODH	Q02127	235	273	244	244	Natural variant	ID=VAR_062418;Note=In POADS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19915526;Dbxref=dbSNP:rs267606768,PMID:19915526
DHODH	Q02127	7	78	34	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	7	78	41	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	7	78	51	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	7	78	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	235	273	226	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	235	273	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	235	273	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
DHODH	Q02127	235	273	261	274	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OQV
CTPS2	Q9NRF8	396	417	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	213	240	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	185	213	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	55	112	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	396	417	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	213	240	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	185	213	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	55	112	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	396	417	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	213	240	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	185	213	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	55	112	1	586	Chain	ID=PRO_0000247033;Note=CTP synthase 2
CTPS2	Q9NRF8	396	417	300	554	Domain	Note=Glutamine amidotransferase type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00605
CTPS2	Q9NRF8	396	417	300	554	Domain	Note=Glutamine amidotransferase type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00605
CTPS2	Q9NRF8	396	417	300	554	Domain	Note=Glutamine amidotransferase type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00605
CTPS2	Q9NRF8	396	417	399	399	Active site	Note=For GATase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00605
CTPS2	Q9NRF8	396	417	399	399	Active site	Note=For GATase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00605
CTPS2	Q9NRF8	396	417	399	399	Active site	Note=For GATase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00605
CTPS2	Q9NRF8	213	240	220	220	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS2	Q9NRF8	213	240	220	220	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS2	Q9NRF8	213	240	220	220	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS2	Q9NRF8	213	240	233	233	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS2	Q9NRF8	213	240	233	233	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS2	Q9NRF8	213	240	233	233	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS2	Q9NRF8	55	112	58	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	58	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	58	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	90	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	90	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	90	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	103	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	103	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	55	112	103	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	187	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	187	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	187	189	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	195	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	195	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	195	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	185	213	212	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	213	240	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHL
CTPS2	Q9NRF8	396	417	395	398	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4U
CTPS2	Q9NRF8	396	417	395	398	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4U
CTPS2	Q9NRF8	396	417	395	398	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4U
CTPS2	Q9NRF8	396	417	400	413	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4U
CTPS2	Q9NRF8	396	417	400	413	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4U
CTPS2	Q9NRF8	396	417	400	413	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4U
IRF4	Q15306	212	248	1	451	Chain	ID=PRO_0000154556;Note=Interferon regulatory factor 4
SPEN	Q96T58	135	293	1	3664	Chain	ID=PRO_0000081627;Note=Msx2-interacting protein
SPEN	Q96T58	347	414	1	3664	Chain	ID=PRO_0000081627;Note=Msx2-interacting protein
SPEN	Q96T58	507	545	1	3664	Chain	ID=PRO_0000081627;Note=Msx2-interacting protein
SPEN	Q96T58	545	583	1	3664	Chain	ID=PRO_0000081627;Note=Msx2-interacting protein
SPEN	Q96T58	3568	3621	1	3664	Chain	ID=PRO_0000081627;Note=Msx2-interacting protein
SPEN	Q96T58	347	414	335	415	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SPEN	Q96T58	507	545	438	513	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SPEN	Q96T58	507	545	517	589	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SPEN	Q96T58	545	583	517	589	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
SPEN	Q96T58	3568	3621	3498	3664	Domain	Note=SPOC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00249
SPEN	Q96T58	135	293	1	573	DNA binding	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPEN	Q96T58	347	414	1	573	DNA binding	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPEN	Q96T58	507	545	1	573	DNA binding	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPEN	Q96T58	545	583	1	573	DNA binding	Ontology_term=ECO:0000250;evidence=ECO:0000250
SPEN	Q96T58	135	293	125	277	Compositional bias	Note=Arg-rich
SPEN	Q96T58	135	293	240	325	Compositional bias	Note=Ser-rich
SPEN	Q96T58	135	293	188	188	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SPEN	Q96T58	135	293	190	190	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SPEN	Q96T58	347	414	348	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	360	362	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	365	371	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	374	376	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	378	385	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	386	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	396	398	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	407	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	347	414	414	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	507	545	507	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	507	545	517	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	507	545	530	537	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	507	545	538	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	507	545	543	549	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	545	583	543	549	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	545	583	550	553	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	545	583	554	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	545	583	562	572	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	545	583	575	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	545	583	583	586	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P6Q
SPEN	Q96T58	3568	3621	3570	3572	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OW1
SPEN	Q96T58	3568	3621	3573	3580	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OW1
SPEN	Q96T58	3568	3621	3585	3598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OW1
SPEN	Q96T58	3568	3621	3600	3606	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OW1
SPEN	Q96T58	3568	3621	3608	3614	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OW1
SPEN	Q96T58	3568	3621	3617	3619	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RT5
ITFG2	Q969R8	64	78	1	447	Chain	ID=PRO_0000289292;Note=KICSTOR complex protein ITFG2
ITFG2	Q969R8	264	282	1	447	Chain	ID=PRO_0000289292;Note=KICSTOR complex protein ITFG2
ITFG2	Q969R8	264	282	148	447	Alternative sequence	ID=VSP_055986;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ITFG2	Q969R8	64	78	68	68	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGBL1	O95965	105	154	24	494	Chain	ID=PRO_5000054386;Note=Integrin beta-like protein 1
ITGBL1	O95965	154	195	24	494	Chain	ID=PRO_5000054386;Note=Integrin beta-like protein 1
ITGBL1	O95965	289	338	24	494	Chain	ID=PRO_5000054386;Note=Integrin beta-like protein 1
ITGBL1	O95965	338	377	24	494	Chain	ID=PRO_5000054386;Note=Integrin beta-like protein 1
ITGBL1	O95965	105	154	96	142	Repeat	Note=II
ITGBL1	O95965	105	154	143	184	Repeat	Note=III
ITGBL1	O95965	154	195	143	184	Repeat	Note=III
ITGBL1	O95965	154	195	185	230	Repeat	Note=IV
ITGBL1	O95965	289	338	276	326	Repeat	Note=VI
ITGBL1	O95965	289	338	327	367	Repeat	Note=VII
ITGBL1	O95965	338	377	327	367	Repeat	Note=VII
ITGBL1	O95965	338	377	368	414	Repeat	Note=VIII
ITGBL1	O95965	105	154	51	494	Region	Note=Cysteine-rich tandem repeats
ITGBL1	O95965	154	195	51	494	Region	Note=Cysteine-rich tandem repeats
ITGBL1	O95965	289	338	51	494	Region	Note=Cysteine-rich tandem repeats
ITGBL1	O95965	338	377	51	494	Region	Note=Cysteine-rich tandem repeats
ITGBL1	O95965	105	154	1	141	Alternative sequence	ID=VSP_054799;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ITGBL1	O95965	105	154	1	105	Alternative sequence	ID=VSP_054800;Note=In isoform 3. MRPPGFRNFLLLASSLLFAGLSAVPQSFSPSLRSWPGAACRLSRAESERRCRAPGQPPGAALCHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCA->MNLVAVMGAFNK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ITGBL1	O95965	105	154	154	154	Natural variant	ID=VAR_039542;Note=A->S;Dbxref=dbSNP:rs1140605
ITGBL1	O95965	154	195	154	154	Natural variant	ID=VAR_039542;Note=A->S;Dbxref=dbSNP:rs1140605
ITGA10	O75578	858	889	23	1167	Chain	ID=PRO_0000016317;Note=Integrin alpha-10
ITGA10	O75578	973	1011	23	1167	Chain	ID=PRO_0000016317;Note=Integrin alpha-10
ITGA10	O75578	1038	1076	23	1167	Chain	ID=PRO_0000016317;Note=Integrin alpha-10
ITGA10	O75578	858	889	23	1122	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA10	O75578	973	1011	23	1122	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA10	O75578	1038	1076	23	1122	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA10	O75578	973	1011	1011	1011	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA10	O75578	1038	1076	1039	1039	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA10	O75578	858	889	125	1167	Alternative sequence	ID=VSP_013115;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ITGA10	O75578	973	1011	125	1167	Alternative sequence	ID=VSP_013115;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ITGA10	O75578	1038	1076	125	1167	Alternative sequence	ID=VSP_013115;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
ITGAL	P20701	455	501	26	1170	Chain	ID=PRO_0000016292;Note=Integrin alpha-L
ITGAL	P20701	715	745	26	1170	Chain	ID=PRO_0000016292;Note=Integrin alpha-L
ITGAL	P20701	745	764	26	1170	Chain	ID=PRO_0000016292;Note=Integrin alpha-L
ITGAL	P20701	954	992	26	1170	Chain	ID=PRO_0000016292;Note=Integrin alpha-L
ITGAL	P20701	455	501	26	1090	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	715	745	26	1090	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	745	764	26	1090	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	954	992	26	1090	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	455	501	446	506	Repeat	Note=FG-GAP 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00803
ITGAL	P20701	455	501	468	476	Calcium binding	Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	715	745	726	726	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	715	745	730	730	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGAL	P20701	745	764	746	746	Alternative sequence	ID=VSP_042843;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ITGAL	P20701	954	992	954	954	Alternative sequence	ID=VSP_002738;Note=In isoform 2. Q->QGVHGLVEMQTSKQILCRPAGDAEHTVGAQEGELPCPWGVSEAFRDNIRAGPCR;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITGAL	P20701	745	764	746	746	Natural variant	ID=VAR_025237;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34838942
ITGAL	P20701	455	501	462	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGAL	P20701	455	501	472	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGAL	P20701	455	501	477	482	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGAL	P20701	455	501	493	499	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITGAL	P20701	455	501	501	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E6S
ITM2B	Q9Y287	151	188	1	266	Chain	ID=PRO_0000045840;Note=Integral membrane protein 2B
ITM2B	Q9Y287	151	188	1	243	Chain	ID=PRO_0000417464;Note=BRI2%2C membrane form
ITM2B	Q9Y287	151	188	76	266	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITM2B	Q9Y287	151	188	137	231	Domain	Note=BRICHOS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00255
ITM2B	Q9Y287	151	188	170	170	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21752865;Dbxref=PMID:21752865
ITM2B	Q9Y287	151	188	164	223	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITM2B	Q9Y287	151	188	83	188	Alternative sequence	ID=VSP_055326;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ITM2B	Q9Y287	151	188	170	170	Mutagenesis	Note=Accumulates in intracellular compartments. Does not inhibit furin%2C ADAM10 and SPPL2A extracellular proteolytic processing activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21752865;Dbxref=PMID:21752865
ITGB5	P18084	672	712	24	799	Chain	ID=PRO_0000016348;Note=Integrin beta-5
ITGB5	P18084	376	421	24	799	Chain	ID=PRO_0000016348;Note=Integrin beta-5
ITGB5	P18084	346	376	24	799	Chain	ID=PRO_0000016348;Note=Integrin beta-5
ITGB5	P18084	314	346	24	799	Chain	ID=PRO_0000016348;Note=Integrin beta-5
ITGB5	P18084	260	314	24	799	Chain	ID=PRO_0000016348;Note=Integrin beta-5
ITGB5	P18084	672	712	24	719	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	376	421	24	719	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	346	376	24	719	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	314	346	24	719	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	260	314	24	719	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	376	421	136	378	Domain	Note=VWFA
ITGB5	P18084	346	376	136	378	Domain	Note=VWFA
ITGB5	P18084	314	346	136	378	Domain	Note=VWFA
ITGB5	P18084	260	314	136	378	Domain	Note=VWFA
ITGB5	P18084	346	376	347	347	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	672	712	705	705	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGB5	P18084	376	421	28	463	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	346	376	28	463	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	314	346	28	463	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	260	314	28	463	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	260	314	259	300	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	376	421	401	413	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	672	712	433	682	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	672	712	641	714	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ITGB5	P18084	672	712	661	690	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
JMY	Q8N9B5	656	688	1	988	Chain	ID=PRO_0000324611;Note=Junction-mediating and -regulatory protein
JSRP1	Q96MG2	87	145	1	331	Chain	ID=PRO_0000314025;Note=Junctional sarcoplasmic reticulum protein 1
JSRP1	Q96MG2	87	145	102	202	Compositional bias	Note=Pro-rich
JSRP1	Q96MG2	87	145	92	92	Natural variant	ID=VAR_037838;Note=V->A;Dbxref=dbSNP:rs10426549
JSRP1	Q96MG2	87	145	108	108	Natural variant	ID=VAR_069019;Note=Polymorphism affecting excitation/contraction coupling in muscle fibers%3B the sensitivity of CACNA1S voltage sensor is shifted to higher depolarizing voltages in cells carrying this variant. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22927026;Dbxref=dbSNP:rs74521370,PMID:22927026
MMAB	Q96EY8	195	214	33	250	Chain	ID=PRO_0000005568;Note=Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase%2C mitochondrial
MMAB	Q96EY8	195	214	214	214	Binding site	Note=ATP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17176040;Dbxref=PMID:17176040
MMAB	Q96EY8	195	214	211	211	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D273
MMAB	Q96EY8	195	214	177	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IDX
MMAB	Q96EY8	195	214	197	203	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IDX
MMAB	Q96EY8	195	214	207	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IDX
KIAA1211	Q6ZU35	95	118	1	1233	Chain	ID=PRO_0000342475;Note=Uncharacterized protein KIAA1211
KIAA1211	Q6ZU35	95	118	1	1233	Chain	ID=PRO_0000342475;Note=Uncharacterized protein KIAA1211
KIAA1257	Q9ULG3	222	269	1	409	Chain	ID=PRO_0000320679;Note=Uncharacterized protein KIAA1257
KIAA1324	Q6UXG2	267	317	42	1013	Chain	ID=PRO_0000286600;Note=UPF0577 protein KIAA1324
KIAA1324	Q6UXG2	406	449	42	1013	Chain	ID=PRO_0000286600;Note=UPF0577 protein KIAA1324
KIAA1324	Q6UXG2	515	561	42	1013	Chain	ID=PRO_0000286600;Note=UPF0577 protein KIAA1324
KIAA1324	Q6UXG2	267	317	42	910	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324	Q6UXG2	406	449	42	910	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324	Q6UXG2	515	561	42	910	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KIAA1324	Q6UXG2	267	317	278	295	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
KIAA1324	Q6UXG2	267	317	308	330	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
KIAA1324	Q6UXG2	267	317	311	342	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
KIAA1324	Q6UXG2	267	317	261	347	Alternative sequence	ID=VSP_025115;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KIAA0556	O60303	136	180	1	1618	Chain	ID=PRO_0000313090;Note=Protein KIAA0556
KIAA0556	O60303	371	393	1	1618	Chain	ID=PRO_0000313090;Note=Protein KIAA0556
KIAA0556	O60303	463	535	1	1618	Chain	ID=PRO_0000313090;Note=Protein KIAA0556
KIAA0556	O60303	874	1115	1	1618	Chain	ID=PRO_0000313090;Note=Protein KIAA0556
KIAA0556	O60303	463	535	522	522	Natural variant	ID=VAR_037654;Note=T->M;Dbxref=dbSNP:rs12930355
KIAA0556	O60303	463	535	535	535	Natural variant	ID=VAR_037655;Note=A->S;Dbxref=dbSNP:rs11643103
KIAA0556	O60303	874	1115	885	885	Natural variant	ID=VAR_037656;Note=R->Q;Dbxref=dbSNP:rs16976970
KIAA1522	Q9P206	136	174	1	1035	Chain	ID=PRO_0000311246;Note=Uncharacterized protein KIAA1522
KIAA1522	Q9P206	174	1028	1	1035	Chain	ID=PRO_0000311246;Note=Uncharacterized protein KIAA1522
KIAA1522	Q9P206	136	174	154	160	Compositional bias	Note=Poly-Arg
KIAA1522	Q9P206	174	1028	319	431	Compositional bias	Note=Ser-rich
KIAA1522	Q9P206	174	1028	438	997	Compositional bias	Note=Pro-rich
KIAA1522	Q9P206	136	174	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	136	174	145	145	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
KIAA1522	Q9P206	136	174	161	161	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	136	174	162	162	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	174	1028	215	215	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
KIAA1522	Q9P206	174	1028	320	320	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2A7S8
KIAA1522	Q9P206	174	1028	322	322	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	174	1028	327	327	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	174	1028	330	330	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2A7S8
KIAA1522	Q9P206	174	1028	338	338	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	174	1028	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:23186163
KIAA1522	Q9P206	174	1028	341	341	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	174	1028	342	342	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:20068231,PMID:23186163
KIAA1522	Q9P206	174	1028	400	400	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
KIAA1522	Q9P206	174	1028	404	404	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2A7S8
KIAA1522	Q9P206	174	1028	409	409	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2A7S8
KIAA1522	Q9P206	174	1028	531	531	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2A7S8
KIAA1522	Q9P206	174	1028	545	545	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:20068231,PMID:21406692,PMID:23186163
KIAA1522	Q9P206	174	1028	593	593	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KIAA1522	Q9P206	174	1028	612	612	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2A7S8
KIAA1522	Q9P206	174	1028	669	669	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:21406692,PMID:23186163,PMID:24275569
KIAA1522	Q9P206	174	1028	673	673	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
KIAA1522	Q9P206	174	1028	858	858	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
KIAA1522	Q9P206	174	1028	862	862	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
KIAA1522	Q9P206	174	1028	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
KIAA1522	Q9P206	174	1028	929	929	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18220336,PMID:18669648,PMID:20068231,PMID:23186163
KIAA1522	Q9P206	174	1028	959	959	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KIAA1522	Q9P206	174	1028	971	971	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:21406692,PMID:23186163
KIAA1522	Q9P206	174	1028	979	979	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
KIAA1522	Q9P206	136	174	137	1028	Alternative sequence	ID=VSP_043215;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA1522	Q9P206	174	1028	137	1028	Alternative sequence	ID=VSP_043215;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA1522	Q9P206	174	1028	232	232	Natural variant	ID=VAR_037192;Note=M->V;Dbxref=dbSNP:rs12730560
KIAA1522	Q9P206	174	1028	310	310	Natural variant	ID=VAR_037193;Note=L->I;Dbxref=dbSNP:rs11582639
KIAA1522	Q9P206	174	1028	770	770	Natural variant	ID=VAR_037194;Note=P->L;Dbxref=dbSNP:rs581875
KIAA1522	Q9P206	174	1028	1021	1021	Natural variant	ID=VAR_037195;Note=E->K;Dbxref=dbSNP:rs675928
KIAA1549L	Q6ZVL6	1506	1623	1	1849	Chain	ID=PRO_0000274780;Note=UPF0606 protein KIAA1549L
KIAA1549L	Q6ZVL6	1506	1623	1230	1849	Alternative sequence	ID=VSP_034447;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA1841	Q6NSI8	404	455	1	718	Chain	ID=PRO_0000324598;Note=Uncharacterized protein KIAA1841
KIAA1841	Q6NSI8	404	455	1	718	Chain	ID=PRO_0000324598;Note=Uncharacterized protein KIAA1841
KIAA1841	Q6NSI8	404	455	380	718	Alternative sequence	ID=VSP_032301;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KIAA1841	Q6NSI8	404	455	380	718	Alternative sequence	ID=VSP_032301;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KRT14	P02533	309	351	1	472	Chain	ID=PRO_0000063653;Note=Keratin%2C type I cytoskeletal 14
KRT14	P02533	255	309	1	472	Chain	ID=PRO_0000063653;Note=Keratin%2C type I cytoskeletal 14
KRT14	P02533	309	351	115	426	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT14	P02533	255	309	115	426	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT14	P02533	255	309	169	260	Region	Note=Coil 1B
KRT14	P02533	255	309	261	283	Region	Note=Linker 12
KRT14	P02533	309	351	284	422	Region	Note=Coil 2
KRT14	P02533	255	309	284	422	Region	Note=Coil 2
KRT14	P02533	255	309	270	270	Natural variant	ID=VAR_003840;Note=In WC-EBS. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7506097;Dbxref=dbSNP:rs58560979,PMID:7506097
KRT14	P02533	255	309	272	272	Natural variant	ID=VAR_003841;Note=In K-EBS. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7682883;Dbxref=dbSNP:rs61371557,PMID:7682883
KRT14	P02533	255	309	272	272	Natural variant	ID=VAR_027719;Note=In K-EBS. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16786515;Dbxref=dbSNP:rs61371557,PMID:16786515
KRT14	P02533	255	309	273	273	Natural variant	ID=VAR_010448;Note=In WC-EBS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9804357;Dbxref=dbSNP:rs59375065,PMID:9804357
KRT14	P02533	255	309	274	274	Natural variant	ID=VAR_010449;Note=In WC-EBS. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7561171;Dbxref=dbSNP:rs58785777,PMID:7561171
KRT14	P02533	309	351	333	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3TNU
KRT78	Q8N1N4	220	252	1	520	Chain	ID=PRO_0000314891;Note=Keratin%2C type II cytoskeletal 78
KRT78	Q8N1N4	220	252	111	424	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT78	Q8N1N4	220	252	166	258	Region	Note=Coil 1B
KRT78	Q8N1N4	220	252	224	224	Natural variant	ID=VAR_038111;Note=G->A;Dbxref=dbSNP:rs2682343
KRT78	Q8N1N4	220	252	238	238	Natural variant	ID=VAR_038112;Note=A->T;Dbxref=dbSNP:rs10876360
KRT78	Q8N1N4	220	252	250	250	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
KRT7	P08729	199	231	2	469	Chain	ID=PRO_0000063725;Note=Keratin%2C type II cytoskeletal 7
KRT7	P08729	231	286	2	469	Chain	ID=PRO_0000063725;Note=Keratin%2C type II cytoskeletal 7
KRT7	P08729	286	328	2	469	Chain	ID=PRO_0000063725;Note=Keratin%2C type II cytoskeletal 7
KRT7	P08729	199	231	91	403	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT7	P08729	231	286	91	403	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT7	P08729	286	328	91	403	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
KRT7	P08729	199	231	145	236	Region	Note=Coil 1B
KRT7	P08729	231	286	145	236	Region	Note=Coil 1B
KRT7	P08729	231	286	237	260	Region	Note=Linker 12
KRT7	P08729	231	286	261	399	Region	Note=Coil 2
KRT7	P08729	286	328	261	399	Region	Note=Coil 2
KRT7	P08729	231	286	252	252	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
KRT7	P08729	231	286	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
KRT7	P08729	286	328	289	289	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KRT7	P08729	231	286	265	265	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KRT7	P08729	231	286	286	286	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KRT7	P08729	286	328	286	286	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KRT7	P08729	286	328	296	296	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
MMRN2	Q9H8L6	218	822	23	949	Chain	ID=PRO_0000007822;Note=Multimerin-2
MMRN2	Q9H8L6	133	160	23	949	Chain	ID=PRO_0000007822;Note=Multimerin-2
MMRN2	Q9H8L6	218	822	821	949	Domain	Note=C1q;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00368
MMRN2	Q9H8L6	218	822	292	487	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	547	596	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	688	711	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	779	806	Compositional bias	Note=Arg/Asp/Glu/Lys-rich (highly charged)
MMRN2	Q9H8L6	218	822	249	249	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	261	261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	350	350	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	379	379	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	439	439	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	472	472	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	727	727	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	765	765	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
MMRN2	Q9H8L6	218	822	448	448	Natural variant	ID=VAR_036362;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs748531029,PMID:16959974
MMRN2	Q9H8L6	218	822	731	731	Natural variant	ID=VAR_019802;Note=H->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11559704,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs4934281,PMID:11559704,PMID:15489334
MMRN2	Q9H8L6	218	822	270	270	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
AK7	Q96M32	203	230	1	723	Chain	ID=PRO_0000158952;Note=Adenylate kinase 7
AK7	Q96M32	290	316	1	723	Chain	ID=PRO_0000158952;Note=Adenylate kinase 7
AK7	Q96M32	366	409	1	723	Chain	ID=PRO_0000158952;Note=Adenylate kinase 7
AK7	Q96M32	452	495	1	723	Chain	ID=PRO_0000158952;Note=Adenylate kinase 7
AK7	Q96M32	495	518	1	723	Chain	ID=PRO_0000158952;Note=Adenylate kinase 7
AK7	Q96M32	658	711	1	723	Chain	ID=PRO_0000158952;Note=Adenylate kinase 7
AK7	Q96M32	366	409	377	382	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK7	Q96M32	452	495	432	455	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK7	Q96M32	452	495	482	485	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK7	Q96M32	366	409	367	612	Region	Note=Adenylate kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21080915;Dbxref=PMID:21080915
AK7	Q96M32	452	495	367	612	Region	Note=Adenylate kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21080915;Dbxref=PMID:21080915
AK7	Q96M32	495	518	367	612	Region	Note=Adenylate kinase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21080915;Dbxref=PMID:21080915
AK7	Q96M32	366	409	397	455	Region	Note=NMPbind;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK7	Q96M32	452	495	397	455	Region	Note=NMPbind;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK7	Q96M32	658	711	679	723	Region	Note=DPY-30;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21080915;Dbxref=PMID:21080915
AK7	Q96M32	203	230	46	458	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AK7	Q96M32	290	316	46	458	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AK7	Q96M32	366	409	46	458	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AK7	Q96M32	452	495	46	458	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AK7	Q96M32	658	711	609	677	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AK7	Q96M32	495	518	497	502	Compositional bias	Note=Poly-Glu
AK7	Q96M32	658	711	616	674	Compositional bias	Note=Glu-rich
AK7	Q96M32	452	495	489	489	Binding site	Note=AMP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P69441
AK7	Q96M32	366	409	389	389	Natural variant	ID=VAR_057950;Note=N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2369679,PMID:14702039
AK7	Q96M32	658	711	673	673	Natural variant	ID=VAR_080917;Note=In SPGF27%3B loss of protein expression in sperm cells%2C no effect in airway epithelial cells. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29365104;Dbxref=dbSNP:rs116298211,PMID:29365104
AK4	P27144	48	88	1	223	Chain	ID=PRO_0000158926;Note=Adenylate kinase 4%2C mitochondrial
AK4	P27144	48	88	1	223	Chain	ID=PRO_0000158926;Note=Adenylate kinase 4%2C mitochondrial
AK4	P27144	48	88	1	223	Chain	ID=PRO_0000158926;Note=Adenylate kinase 4%2C mitochondrial
AK4	P27144	48	88	62	64	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03170,ECO:0000269|Ref.13
AK4	P27144	48	88	62	64	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03170,ECO:0000269|Ref.13
AK4	P27144	48	88	62	64	Nucleotide binding	Note=AMP;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03170,ECO:0000269|Ref.13
AK4	P27144	48	88	35	64	Region	Note=NMPbind;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03170,ECO:0000269|PubMed:19073142;Dbxref=PMID:19073142
AK4	P27144	48	88	35	64	Region	Note=NMPbind;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03170,ECO:0000269|PubMed:19073142;Dbxref=PMID:19073142
AK4	P27144	48	88	35	64	Region	Note=NMPbind;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03170,ECO:0000269|PubMed:19073142;Dbxref=PMID:19073142
AK4	P27144	48	88	60	60	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUR9
AK4	P27144	48	88	60	60	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUR9
AK4	P27144	48	88	60	60	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUR9
AK4	P27144	48	88	49	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	49	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	49	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	66	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	66	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	66	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	79	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AR7
AK4	P27144	48	88	79	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AR7
AK4	P27144	48	88	79	82	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AR7
AK4	P27144	48	88	85	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	85	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
AK4	P27144	48	88	85	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBW
SFTPC	P11686	14	67	1	23	Propeptide	ID=PRO_0000033477;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3366248;Dbxref=PMID:3366248
SFTPC	P11686	14	67	24	58	Chain	ID=PRO_0000033478;Note=Pulmonary surfactant-associated protein C
SFTPC	P11686	14	67	59	197	Propeptide	ID=PRO_0000033479
SFTPC	P11686	108	145	59	197	Propeptide	ID=PRO_0000033479
SFTPC	P11686	108	145	94	197	Domain	Note=BRICHOS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00255
SFTPC	P11686	14	67	28	28	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2326260;Dbxref=PMID:2326260
SFTPC	P11686	14	67	29	29	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2326260;Dbxref=PMID:2326260
SFTPC	P11686	108	145	120	148	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22308375;Dbxref=PMID:22308375
SFTPC	P11686	108	145	121	189	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22308375;Dbxref=PMID:22308375
SFTPC	P11686	14	67	66	66	Natural variant	ID=VAR_036855;Note=In SMDP2%3B targeted abnormally to early endosomes and likely to result in a toxic gain of function. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15557112;Dbxref=PMID:15557112
SFTPC	P11686	108	145	116	116	Natural variant	ID=VAR_026754;Note=In SMDP2. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15647591;Dbxref=PMID:15647591
SFTPC	P11686	108	145	138	138	Natural variant	ID=VAR_007453;Note=Influences susceptibility to RDS in premature infants. N->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:14735158,ECO:0000269|PubMed:16421571,ECO:0000269|PubMed:2839484,ECO:0000269|PubMed:8181452,ECO:0000269|Ref.10,ECO:0000269|Ref.5,ECO:0000269|Ref.8;Dbxref=dbSNP:rs4715,PMID:14702039,PMID:14735158,PMID:16421571,PMID:2839484,PMID:8181452
SFTPC	P11686	14	67	14	14	Sequence conflict	Note=P->PPCQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFTPC	P11686	14	67	45	45	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFTPC	P11686	14	67	65	67	Sequence conflict	Note=TEM->FPQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
SFTPC	P11686	108	145	106	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAD
SFTPC	P11686	108	145	110	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAD
SFTPC	P11686	108	145	121	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAD
SFTPC	P11686	108	145	134	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YAD
PSME4	Q14997	1648	1700	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	1605	1648	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	1397	1432	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	1304	1346	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	1141	1158	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	981	1025	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	278	319	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	167	181	1	1843	Chain	ID=PRO_0000280718;Note=Proteasome activator complex subunit 4
PSME4	Q14997	981	1025	998	1037	Repeat	Note=HEAT 2
PSME4	Q14997	1648	1700	1636	1674	Repeat	Note=HEAT 5
PSME4	Q14997	1605	1648	1636	1674	Repeat	Note=HEAT 5
PSME4	Q14997	1648	1700	1680	1718	Repeat	Note=HEAT 6
PSME4	Q14997	1648	1700	1650	1738	Region	Note=Bromodomain-like (BRDL)
PSME4	Q14997	1605	1648	1614	1614	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSME4	Q14997	1605	1648	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	1397	1432	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	1304	1346	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	1141	1158	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	981	1025	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	278	319	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	167	181	1	1628	Alternative sequence	ID=VSP_023876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSME4	Q14997	278	319	1	856	Alternative sequence	ID=VSP_023877;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PSME4	Q14997	167	181	1	856	Alternative sequence	ID=VSP_023877;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PSME4	Q14997	278	319	1	625	Alternative sequence	ID=VSP_023878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PSME4	Q14997	167	181	1	625	Alternative sequence	ID=VSP_023878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PSME4	Q14997	981	1025	984	984	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSME4	Q14997	1397	1432	1401	1401	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRG	P23470	28	63	20	1445	Chain	ID=PRO_0000025441;Note=Receptor-type tyrosine-protein phosphatase gamma
PTPRG	P23470	63	123	20	1445	Chain	ID=PRO_0000025441;Note=Receptor-type tyrosine-protein phosphatase gamma
PTPRG	P23470	173	205	20	1445	Chain	ID=PRO_0000025441;Note=Receptor-type tyrosine-protein phosphatase gamma
PTPRG	P23470	763	791	20	1445	Chain	ID=PRO_0000025441;Note=Receptor-type tyrosine-protein phosphatase gamma
PTPRG	P23470	1255	1304	20	1445	Chain	ID=PRO_0000025441;Note=Receptor-type tyrosine-protein phosphatase gamma
PTPRG	P23470	28	63	20	736	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRG	P23470	63	123	20	736	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRG	P23470	173	205	20	736	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRG	P23470	763	791	763	1445	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRG	P23470	1255	1304	763	1445	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRG	P23470	28	63	58	321	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
PTPRG	P23470	63	123	58	321	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
PTPRG	P23470	173	205	58	321	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
PTPRG	P23470	1255	1304	1150	1410	Domain	Note=Tyrosine-protein phosphatase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPRG	P23470	63	123	109	109	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
PTPRG	P23470	63	123	113	113	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
PTPRG	P23470	63	123	78	261	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20133774;Dbxref=PMID:20133774
PTPRG	P23470	173	205	78	261	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20133774;Dbxref=PMID:20133774
PTPRG	P23470	763	791	764	792	Alternative sequence	ID=VSP_024353;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
PTPRG	P23470	63	123	92	92	Natural variant	ID=VAR_070892;Note=Y->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:8833149;Dbxref=dbSNP:rs62620047,PMID:15489334,PMID:8833149
PTPRG	P23470	63	123	80	80	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTPRG	P23470	63	123	64	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	63	123	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	63	123	71	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	63	123	76	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	63	123	80	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5R
PTPRG	P23470	63	123	90	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	63	123	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	63	123	116	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	173	205	171	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	173	205	181	183	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	173	205	187	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	173	205	197	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3JXH
PTPRG	P23470	1255	1304	1270	1272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NLK
PTPRG	P23470	1255	1304	1275	1286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NLK
PTPRG	P23470	1255	1304	1292	1305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NLK
PUF60	Q9UHX1	170	201	1	559	Chain	ID=PRO_0000299519;Note=Poly(U)-binding-splicing factor PUF60
PUF60	Q9UHX1	99	116	1	559	Chain	ID=PRO_0000299519;Note=Poly(U)-binding-splicing factor PUF60
PUF60	Q9UHX1	170	201	129	207	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PUF60	Q9UHX1	170	201	1	516	Region	Note=Inhibits homodimerization
PUF60	Q9UHX1	99	116	1	516	Region	Note=Inhibits homodimerization
PUF60	Q9UHX1	170	201	77	559	Region	Note=Inhibits transcriptional repression%2C interaction with ERCC3 and apoptosis induction
PUF60	Q9UHX1	99	116	77	559	Region	Note=Inhibits transcriptional repression%2C interaction with ERCC3 and apoptosis induction
PUF60	Q9UHX1	99	116	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
PUF60	Q9UHX1	99	116	101	117	Alternative sequence	ID=VSP_027719;Note=In isoform 2%2C isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10882074,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.7;Dbxref=PMID:10882074,PMID:15489334
PUF60	Q9UHX1	170	201	171	179	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KW6
PUF60	Q9UHX1	170	201	180	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KW6
PUF60	Q9UHX1	170	201	194	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UWT
PUF60	Q9UHX1	170	201	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KW6
PUM1	Q14671	996	1038	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	950	996	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	695	774	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	548	596	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	417	451	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	121	144	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	996	1038	828	1168	Domain	Note=PUM-HD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00318
PUM1	Q14671	950	996	828	1168	Domain	Note=PUM-HD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00318
PUM1	Q14671	950	996	920	955	Repeat	Note=Pumilio 3;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	950	996	956	991	Repeat	Note=Pumilio 4;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	996	1038	992	1027	Repeat	Note=Pumilio 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	950	996	992	1027	Repeat	Note=Pumilio 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	996	1038	1028	1063	Repeat	Note=Pumilio 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	950	996	971	975	Region	Note=Non-specific-nucleotide binding in RNA target;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18328718;Dbxref=PMID:18328718
PUM1	Q14671	996	1038	1007	1011	Region	Note=Adenine-nucleotide binding in RNA target;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18328718;Dbxref=PMID:18328718
PUM1	Q14671	548	596	393	613	Compositional bias	Note=Ala-rich
PUM1	Q14671	417	451	393	613	Compositional bias	Note=Ala-rich
PUM1	Q14671	695	774	642	815	Compositional bias	Note=Ser-rich
PUM1	Q14671	121	144	124	124	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
PUM1	Q14671	695	774	709	709	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PUM1	Q14671	695	774	714	714	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20818387;Dbxref=PMID:20818387
PUM1	Q14671	417	451	417	417	Alternative sequence	ID=VSP_017059;Note=In isoform 2 and isoform 4. I->IA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7788527;Dbxref=PMID:14702039,PMID:7788527
PUM1	Q14671	950	996	950	950	Alternative sequence	ID=VSP_017061;Note=In isoform 2 and isoform 3. Q->QVI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7788527,ECO:0000303|Ref.4;Dbxref=PMID:7788527
PUM1	Q14671	996	1038	1033	1033	Natural variant	ID=VAR_080784;Note=In SCA47%3B results in reduced PUM1 protein levels and decreased post-transcriptional repression of E2F3 and ATXN1. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29474920;Dbxref=PMID:29474920
PUM1	Q14671	695	774	714	714	Mutagenesis	Note=Decreased RNA-binding activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20818387;Dbxref=PMID:20818387
PUM1	Q14671	695	774	714	714	Mutagenesis	Note=Phospho-mimic mutant%3B persistent RNA-binding activity in quiescent cells. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20818387;Dbxref=PMID:20818387
PUM1	Q14671	950	996	971	975	Mutagenesis	Note=Specifically binds cytosine-nucleotide in RNA target. NHVVQ->GHVVR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	996	1038	1007	1011	Mutagenesis	Note=Specifically binds cytosine-nucleotide in RNA target. CRVIQ->GRVIR%2CARVIR%2CSRVIR%2CTRVIR%2CCRVIR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	996	1038	1007	1011	Mutagenesis	Note=Specifically binds guanine-nucleotide in RNA target. CRVIQ->SRVIE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	996	1038	1007	1007	Mutagenesis	Note=Specifically binds uracil-nucleotide in RNA target. C->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	950	996	947	954	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	955	957	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	961	966	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	970	980	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	983	986	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	987	992	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	993	996	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	993	996	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	997	1001	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	1006	1016	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	1019	1031	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	1033	1036	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PFAS	O15067	227	273	1	1338	Chain	ID=PRO_0000100401;Note=Phosphoribosylformylglycinamidine synthase
PFAS	O15067	543	597	1	1338	Chain	ID=PRO_0000100401;Note=Phosphoribosylformylglycinamidine synthase
PFAS	O15067	639	683	1	1338	Chain	ID=PRO_0000100401;Note=Phosphoribosylformylglycinamidine synthase
PFAS	O15067	543	597	569	569	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163
RPL19	P84098	37	78	1	196	Chain	ID=PRO_0000131169;Note=60S ribosomal protein L19
RPL19	P84098	119	155	1	196	Chain	ID=PRO_0000131169;Note=60S ribosomal protein L19
RPL19	P84098	37	78	38	38	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
PUS7L	Q9H0K6	575	593	1	701	Chain	ID=PRO_0000316785;Note=Pseudouridylate synthase 7 homolog-like protein
PUS7L	Q9H0K6	421	454	1	701	Chain	ID=PRO_0000316785;Note=Pseudouridylate synthase 7 homolog-like protein
PUS7L	Q9H0K6	575	593	1	701	Chain	ID=PRO_0000316785;Note=Pseudouridylate synthase 7 homolog-like protein
PUS7L	Q9H0K6	421	454	1	701	Chain	ID=PRO_0000316785;Note=Pseudouridylate synthase 7 homolog-like protein
PUS7L	Q9H0K6	575	593	1	701	Chain	ID=PRO_0000316785;Note=Pseudouridylate synthase 7 homolog-like protein
PUS7L	Q9H0K6	421	454	1	701	Chain	ID=PRO_0000316785;Note=Pseudouridylate synthase 7 homolog-like protein
PUS7L	Q9H0K6	575	593	424	647	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7L	Q9H0K6	421	454	424	647	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7L	Q9H0K6	575	593	424	647	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7L	Q9H0K6	421	454	424	647	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7L	Q9H0K6	575	593	424	647	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7L	Q9H0K6	421	454	424	647	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUSL1	Q8N0Z8	158	214	1	303	Chain	ID=PRO_0000057522;Note=tRNA pseudouridine synthase-like 1
PUSL1	Q8N0Z8	158	214	1	161	Alternative sequence	ID=VSP_036048;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PUSL1	Q8N0Z8	158	214	197	197	Natural variant	ID=VAR_051869;Note=R->W;Dbxref=dbSNP:rs34738574
PWP1	Q13610	167	204	1	501	Chain	ID=PRO_0000051171;Note=Periodic tryptophan protein 1 homolog
PWP1	Q13610	167	204	116	171	Repeat	Note=WD 1
PWP1	Q13610	167	204	177	222	Repeat	Note=WD 2
PWP1	Q13610	167	204	148	501	Alternative sequence	ID=VSP_056169;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PXDN	Q92626	339	430	27	1479	Chain	ID=PRO_0000319619;Note=Peroxidasin homolog
PXDN	Q92626	115	138	27	1479	Chain	ID=PRO_0000319619;Note=Peroxidasin homolog
PXDN	Q92626	115	138	111	132	Repeat	Note=LRR 2
PXDN	Q92626	115	138	135	156	Repeat	Note=LRR 3
PXDN	Q92626	339	430	342	428	Domain	Note=Ig-like C2-type 2
PXDN	Q92626	339	430	363	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
PYGB	P11216	285	333	2	843	Chain	ID=PRO_0000188535;Note=Glycogen phosphorylase%2C brain form
PYGB	P11216	285	333	310	310	Binding site	Note=AMP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27402852;Dbxref=PMID:27402852
PYGB	P11216	285	333	303	303	Natural variant	ID=VAR_034428;Note=A->S;Dbxref=dbSNP:rs2228976
PYGB	P11216	285	333	302	302	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PYGB	P11216	285	333	290	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IKO
PYGB	P11216	285	333	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IKO
PYGB	P11216	285	333	330	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IKO
PYGM	P11217	726	770	2	842	Chain	ID=PRO_0000188529;Note=Glycogen phosphorylase%2C muscle form
PYGM	P11217	726	770	747	747	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09812
PYGM	P11217	726	770	748	748	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09812
PYGM	P11217	726	770	730	733	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8D
PYGM	P11217	726	770	737	748	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8D
PYGM	P11217	726	770	749	751	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8D
PYGM	P11217	726	770	756	759	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8D
PYGM	P11217	726	770	760	768	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z8D
PSMA7	O14818	197	218	1	248	Chain	ID=PRO_0000124142;Note=Proteasome subunit alpha type-7
PSMA7	O14818	157	197	1	248	Chain	ID=PRO_0000124142;Note=Proteasome subunit alpha type-7
PSMA7	O14818	116	157	1	248	Chain	ID=PRO_0000124142;Note=Proteasome subunit alpha type-7
PSMA7	O14818	116	157	153	153	Modified residue	Note=Phosphotyrosine%3B by ABL1 and ABL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678104;Dbxref=PMID:16678104
PSMA7	O14818	116	157	130	130	Glycosylation	Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000250;evidence=ECO:0000250
PSMA7	O14818	116	157	117	149	Alternative sequence	ID=VSP_046556;Note=In isoform 3. RYTQSNGRRPFGISALIVGFDFDGTPRLYQTDP->VGACPLACSPLAAGQSRLRHGGSCHVTSGESEN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSMA7	O14818	197	218	150	248	Alternative sequence	ID=VSP_046557;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSMA7	O14818	157	197	150	248	Alternative sequence	ID=VSP_046557;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSMA7	O14818	116	157	150	248	Alternative sequence	ID=VSP_046557;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PSMA7	O14818	116	157	153	153	Mutagenesis	Note=Displays impaired G1/S transition and S/G2 progression. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678104;Dbxref=PMID:16678104
PSMA7	O14818	157	197	160	160	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMA7	O14818	116	157	104	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	116	157	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	116	157	129	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	116	157	142	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	157	197	153	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	116	157	153	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	157	197	165	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	157	197	178	181	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	157	197	184	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	197	218	199	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R67
PSMA7	O14818	197	218	202	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	197	218	213	215	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMA7	O14818	197	218	216	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LF6
PSMB6	P28072	57	100	35	239	Chain	ID=PRO_0000026614;Note=Proteasome subunit beta type-6
PSMB6	P28072	57	100	69	69	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PSMB6	P28072	57	100	59	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMB6	P28072	57	100	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMB6	P28072	57	100	75	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PSMB6	P28072	57	100	83	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LE5
PTOV1	Q86YD1	150	186	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	186	238	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	312	347	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	150	186	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	186	238	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	312	347	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	150	186	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	186	238	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	312	347	1	416	Chain	ID=PRO_0000304965;Note=Prostate tumor-overexpressed gene 1 protein
PTOV1	Q86YD1	150	186	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	186	238	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	312	347	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	150	186	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	186	238	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	312	347	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	150	186	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	186	238	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	312	347	184	416	Region	Note=Interaction with FLOT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713644;Dbxref=PMID:15713644
PTOV1	Q86YD1	150	186	1	189	Alternative sequence	ID=VSP_028153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PTOV1	Q86YD1	186	238	1	189	Alternative sequence	ID=VSP_028153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PTOV1	Q86YD1	150	186	1	189	Alternative sequence	ID=VSP_028153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PTOV1	Q86YD1	186	238	1	189	Alternative sequence	ID=VSP_028153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PTOV1	Q86YD1	150	186	1	189	Alternative sequence	ID=VSP_028153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PTOV1	Q86YD1	186	238	1	189	Alternative sequence	ID=VSP_028153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
PTPN21	Q16825	957	1000	1	1174	Chain	ID=PRO_0000219439;Note=Tyrosine-protein phosphatase non-receptor type 21
PTPN21	Q16825	957	1000	1	1174	Chain	ID=PRO_0000219439;Note=Tyrosine-protein phosphatase non-receptor type 21
PTPN21	Q16825	957	1000	896	1167	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPN21	Q16825	957	1000	896	1167	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160
PTPDC1	A2A3K4	85	111	1	754	Chain	ID=PRO_0000312212;Note=Protein tyrosine phosphatase domain-containing protein 1
PTPDC1	A2A3K4	617	679	1	754	Chain	ID=PRO_0000312212;Note=Protein tyrosine phosphatase domain-containing protein 1
PTPDC1	A2A3K4	679	716	1	754	Chain	ID=PRO_0000312212;Note=Protein tyrosine phosphatase domain-containing protein 1
PTPN3	P26045	500	526	1	913	Chain	ID=PRO_0000219433;Note=Tyrosine-protein phosphatase non-receptor type 3
PTPN3	P26045	334	378	1	913	Chain	ID=PRO_0000219433;Note=Tyrosine-protein phosphatase non-receptor type 3
PTPN3	P26045	46	82	1	913	Chain	ID=PRO_0000219433;Note=Tyrosine-protein phosphatase non-receptor type 3
PTPN3	P26045	46	82	29	312	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTPN3	P26045	500	526	510	582	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
PTPN3	P26045	334	378	357	357	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PTPN3	P26045	334	378	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
PTPN3	P26045	334	378	367	367	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PTPN3	P26045	334	378	376	376	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
PTPN3	P26045	46	82	1	131	Alternative sequence	ID=VSP_046309;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PTPN3	P26045	334	378	335	379	Alternative sequence	ID=VSP_046310;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
PTPN3	P26045	46	82	77	77	Natural variant	ID=VAR_055252;Note=D->N;Dbxref=dbSNP:rs35285139
PEX11G	Q96HA9	143	163	1	241	Chain	ID=PRO_0000105970;Note=Peroxisomal membrane protein 11C
PEX11G	Q96HA9	143	163	125	149	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
PEX11G	Q96HA9	143	163	150	211	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PYROXD1	Q8WU10	28	55	1	500	Chain	ID=PRO_0000327419;Note=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
PYROXD1	Q8WU10	55	95	1	500	Chain	ID=PRO_0000327419;Note=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
PYROXD1	Q8WU10	95	138	1	500	Chain	ID=PRO_0000327419;Note=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
PYROXD1	Q8WU10	28	55	1	71	Alternative sequence	ID=VSP_055828;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PYROXD1	Q8WU10	55	95	1	71	Alternative sequence	ID=VSP_055828;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBMS3	Q6XE24	296	313	1	437	Chain	ID=PRO_0000274906;Note=RNA-binding motif%2C single-stranded-interacting protein 3
RBMS3	Q6XE24	350	366	1	437	Chain	ID=PRO_0000274906;Note=RNA-binding motif%2C single-stranded-interacting protein 3
RBMS3	Q6XE24	296	313	297	313	Alternative sequence	ID=VSP_022929;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
RBMS3	Q6XE24	350	366	351	366	Alternative sequence	ID=VSP_022930;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10675610,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:10675610,PMID:14702039,PMID:15489334
RBM23	Q86U06	134	151	1	439	Chain	ID=PRO_0000081783;Note=Probable RNA-binding protein 23
RBM23	Q86U06	76	133	1	439	Chain	ID=PRO_0000081783;Note=Probable RNA-binding protein 23
RBM23	Q86U06	60	75	1	439	Chain	ID=PRO_0000081783;Note=Probable RNA-binding protein 23
RBM23	Q86U06	76	133	63	127	Compositional bias	Note=Arg-rich
RBM23	Q86U06	60	75	63	127	Compositional bias	Note=Arg-rich
RBM23	Q86U06	76	133	128	128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBM23	Q86U06	134	151	149	149	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163
RBM23	Q86U06	76	133	1	100	Alternative sequence	ID=VSP_008311;Note=In isoform 5. MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSKKKRSRSHNKSRDRKRSRSRDRDRYRRRNSRSRSPGRQCRH->MSNKGKKLKRIILAIPPAAPATVAMRPVEAAPSGRQARRRGVGAIIKAGIESAVVVEIGIGIDGEIVGAEVQVGSVVT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
RBM23	Q86U06	60	75	1	100	Alternative sequence	ID=VSP_008311;Note=In isoform 5. MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSKKKRSRSHNKSRDRKRSRSRDRDRYRRRNSRSRSPGRQCRH->MSNKGKKLKRIILAIPPAAPATVAMRPVEAAPSGRQARRRGVGAIIKAGIESAVVVEIGIGIDGEIVGAEVQVGSVVT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
RBM23	Q86U06	76	133	60	76	Alternative sequence	ID=VSP_008312;Note=In isoform 2 and isoform 4. KKKRSRSHNKSRDRKRS->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334
RBM23	Q86U06	60	75	60	76	Alternative sequence	ID=VSP_008312;Note=In isoform 2 and isoform 4. KKKRSRSHNKSRDRKRS->N;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334
RBM23	Q86U06	134	151	135	152	Alternative sequence	ID=VSP_008313;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBM23	Q86U06	76	133	132	132	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTPS1	P17812	213	240	1	591	Chain	ID=PRO_0000138275;Note=CTP synthase 1
CTPS1	P17812	213	240	1	591	Chain	ID=PRO_0000138275;Note=CTP synthase 1
CTPS1	P17812	213	240	1	231	Alternative sequence	ID=VSP_055827;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CTPS1	P17812	213	240	1	231	Alternative sequence	ID=VSP_055827;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CTPS1	P17812	213	240	212	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VO1
CTPS1	P17812	213	240	212	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VO1
CTPS1	P17812	213	240	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VO1
CTPS1	P17812	213	240	224	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VO1
CTPS1	P17812	213	240	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VO1
CTPS1	P17812	213	240	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VO1
RBM47	A0AV96	374	443	1	593	Chain	ID=PRO_0000307855;Note=RNA-binding protein 47
RBM47	A0AV96	374	443	1	593	Chain	ID=PRO_0000307855;Note=RNA-binding protein 47
RBM47	A0AV96	374	443	394	394	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	394	394	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	394	394	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	394	394	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	405	405	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	405	405	Modified residue	Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	405	405	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	405	405	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
RBM47	A0AV96	374	443	375	443	Alternative sequence	ID=VSP_028839;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBM47	A0AV96	374	443	375	443	Alternative sequence	ID=VSP_028839;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBPMS	Q93062	22	48	1	196	Chain	ID=PRO_0000081793;Note=RNA-binding protein with multiple splicing
RBPMS	Q93062	61	82	1	196	Chain	ID=PRO_0000081793;Note=RNA-binding protein with multiple splicing
RBPMS	Q93062	22	48	1	196	Chain	ID=PRO_0000081793;Note=RNA-binding protein with multiple splicing
RBPMS	Q93062	61	82	1	196	Chain	ID=PRO_0000081793;Note=RNA-binding protein with multiple splicing
RBPMS	Q93062	22	48	24	101	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBPMS	Q93062	61	82	24	101	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBPMS	Q93062	22	48	24	101	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBPMS	Q93062	61	82	24	101	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBPMS	Q93062	22	48	27	27	Site	Note=Interaction with RNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	22	48	27	27	Site	Note=Interaction with RNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	61	82	61	61	Site	Note=Interaction with RNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	61	82	61	61	Site	Note=Interaction with RNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	22	48	27	27	Mutagenesis	Note=Abolishes RNA binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	22	48	27	27	Mutagenesis	Note=Abolishes RNA binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	22	48	36	38	Mutagenesis	Note=Impairs dimerization and RNA binding. KPR->EPE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	22	48	36	38	Mutagenesis	Note=Impairs dimerization and RNA binding. KPR->EPE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	61	82	65	65	Mutagenesis	Note=Abolishes RNA binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	61	82	65	65	Mutagenesis	Note=Abolishes RNA binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26347403;Dbxref=PMID:26347403
RBPMS	Q93062	22	48	25	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	22	48	25	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	22	48	37	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	22	48	37	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	61	82	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	61	82	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	61	82	63	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	61	82	63	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	61	82	71	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RBPMS	Q93062	61	82	71	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CYJ
RANBP10	Q6VN20	133	189	2	620	Chain	ID=PRO_0000305237;Note=Ran-binding protein 10
RANBP10	Q6VN20	133	189	35	222	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
RANBP10	Q6VN20	133	189	134	189	Alternative sequence	ID=VSP_055840;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RBM27	Q9P2N5	196	283	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	426	481	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	481	531	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	631	730	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	730	777	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	777	817	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	932	996	1	1060	Chain	ID=PRO_0000273044;Note=RNA-binding protein 27
RBM27	Q9P2N5	631	730	600	674	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
RBM27	Q9P2N5	196	283	273	301	Zinc finger	Note=C3H1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
RBM27	Q9P2N5	777	817	809	886	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
RBM27	Q9P2N5	196	283	131	201	Compositional bias	Note=Arg-rich
RBM27	Q9P2N5	631	730	678	718	Compositional bias	Note=Gln-rich
RBM27	Q9P2N5	426	481	447	447	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18220336,PMID:20068231,PMID:23186163,PMID:24275569
RBM27	Q9P2N5	426	481	455	455	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PPP1R36	Q96LQ0	45	60	1	422	Chain	ID=PRO_0000089893;Note=Protein phosphatase 1 regulatory subunit 36
PPP1R36	Q96LQ0	178	222	1	422	Chain	ID=PRO_0000089893;Note=Protein phosphatase 1 regulatory subunit 36
PPP1R42	Q7Z4L9	223	267	1	309	Chain	ID=PRO_0000326175;Note=Protein phosphatase 1 regulatory subunit 42
PPP1R42	Q7Z4L9	223	267	204	242	Domain	Note=LRRCT
PPP1R42	Q7Z4L9	223	267	224	228	Alternative sequence	ID=VSP_032587;Note=In isoform 2. EFLDG->GTYLY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPP1R42	Q7Z4L9	223	267	229	309	Alternative sequence	ID=VSP_032588;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PREX2	Q70Z35	1241	1255	1	1606	Chain	ID=PRO_0000286795;Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate-dependent Rac exchanger 2 protein
PREX2	Q70Z35	1241	1255	980	1606	Alternative sequence	ID=VSP_025152;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
PREX2	Q70Z35	1241	1255	1050	1606	Alternative sequence	ID=VSP_055614;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PREX2	Q70Z35	1241	1255	1242	1255	Alternative sequence	ID=VSP_025157;Note=In isoform 2. EVKCRLLLALLEYS->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRICKLE2	Q7Z3G6	188	256	1	841	Chain	ID=PRO_0000075891;Note=Prickle-like protein 2
PRICKLE2	Q7Z3G6	188	256	128	193	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE2	Q7Z3G6	188	256	193	253	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PRICKLE2	Q7Z3G6	188	256	253	317	Domain	Note=LIM zinc-binding 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
PROM1	O43490	838	860	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	760	791	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	661	692	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	589	637	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	838	860	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	760	791	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	661	692	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	589	637	20	865	Chain	ID=PRO_0000025813;Note=Prominin-1
PROM1	O43490	760	791	508	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	661	692	508	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	589	637	508	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	760	791	508	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	661	692	508	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	589	637	508	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	838	860	814	865	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	838	860	814	865	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM1	O43490	838	860	831	861	Alternative sequence	ID=VSP_040001;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM1	O43490	838	860	831	861	Alternative sequence	ID=VSP_040001;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM1	O43490	838	860	831	839	Alternative sequence	ID=VSP_040002;Note=In isoform 3. VETIPMKNM->SSWVTSVQC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PROM1	O43490	838	860	831	839	Alternative sequence	ID=VSP_040002;Note=In isoform 3. VETIPMKNM->SSWVTSVQC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PROM1	O43490	838	860	839	861	Alternative sequence	ID=VSP_040003;Note=In isoform 4 and isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM1	O43490	838	860	839	861	Alternative sequence	ID=VSP_040003;Note=In isoform 4 and isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM1	O43490	838	860	840	865	Alternative sequence	ID=VSP_040004;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PROM1	O43490	838	860	840	865	Alternative sequence	ID=VSP_040004;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
PROM2	Q8N271	227	257	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	576	625	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	698	725	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	725	748	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	227	257	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	576	625	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	698	725	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	725	748	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	227	257	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	576	625	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	698	725	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	725	748	27	834	Chain	ID=PRO_0000331239;Note=Prominin-2
PROM2	Q8N271	227	257	175	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	227	257	175	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	227	257	175	426	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	576	625	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	698	725	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	725	748	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	576	625	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	698	725	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	725	748	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	576	625	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	698	725	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	725	748	494	779	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PROM2	Q8N271	725	748	727	727	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PROM2	Q8N271	725	748	727	727	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PROM2	Q8N271	725	748	727	727	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
PROM2	Q8N271	227	257	1	474	Alternative sequence	ID=VSP_033148;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PROM2	Q8N271	227	257	1	474	Alternative sequence	ID=VSP_033148;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PROM2	Q8N271	227	257	1	474	Alternative sequence	ID=VSP_033148;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PROM2	Q8N271	576	625	576	624	Alternative sequence	ID=VSP_033149;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PROM2	Q8N271	576	625	576	624	Alternative sequence	ID=VSP_033149;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PROM2	Q8N271	576	625	576	624	Alternative sequence	ID=VSP_033149;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PROM2	Q8N271	698	725	701	701	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM2	Q8N271	698	725	701	701	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM2	Q8N271	698	725	701	701	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM2	Q8N271	698	725	704	704	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM2	Q8N271	698	725	704	704	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PROM2	Q8N271	698	725	704	704	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRPS2	P11908	177	234	2	318	Chain	ID=PRO_0000141074;Note=Ribose-phosphate pyrophosphokinase 2
PRPS2	P11908	177	234	212	227	Region	Note=Binding of phosphoribosylpyrophosphate;Ontology_term=ECO:0000255;evidence=ECO:0000255
PSMC1	P62191	93	155	2	440	Chain	ID=PRO_0000084677;Note=26S proteasome regulatory subunit 4
PSMC1	P62191	155	198	2	440	Chain	ID=PRO_0000084677;Note=26S proteasome regulatory subunit 4
PSMC1	P62191	93	155	120	120	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
PSMD12	O00232	170	220	2	456	Chain	ID=PRO_0000173861;Note=26S proteasome non-ATPase regulatory subunit 12
PSMD12	O00232	135	170	2	456	Chain	ID=PRO_0000173861;Note=26S proteasome non-ATPase regulatory subunit 12
PSMD12	O00232	99	135	2	456	Chain	ID=PRO_0000173861;Note=26S proteasome non-ATPase regulatory subunit 12
PSMD13	Q9UNM6	103	132	1	376	Chain	ID=PRO_0000173867;Note=26S proteasome non-ATPase regulatory subunit 13
PSMD13	Q9UNM6	258	279	1	376	Chain	ID=PRO_0000173867;Note=26S proteasome non-ATPase regulatory subunit 13
PSMD13	Q9UNM6	279	306	1	376	Chain	ID=PRO_0000173867;Note=26S proteasome non-ATPase regulatory subunit 13
PSMD13	Q9UNM6	306	345	1	376	Chain	ID=PRO_0000173867;Note=26S proteasome non-ATPase regulatory subunit 13
PSMD13	Q9UNM6	258	279	171	338	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD13	Q9UNM6	279	306	171	338	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD13	Q9UNM6	306	345	171	338	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
PSMD13	Q9UNM6	279	306	298	298	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GINS3	Q9BRX5	62	140	1	216	Chain	ID=PRO_0000327615;Note=DNA replication complex GINS protein PSF3
GINS3	Q9BRX5	62	140	62	139	Alternative sequence	ID=VSP_032737;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
GINS3	Q9BRX5	62	140	63	63	Alternative sequence	ID=VSP_046694;Note=In isoform 3. G->GFALLPRLECSGVIWLTAALTSQAPEILPPQPPMWLVLQG;Ontology_term=ECO:0000305;evidence=ECO:0000305
GINS3	Q9BRX5	62	140	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	70	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	79	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	90	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	94	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	104	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	116	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	123	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
GINS3	Q9BRX5	62	140	131	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9X
DGKA	P23743	91	116	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	306	339	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	392	416	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	91	116	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	306	339	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	392	416	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	91	116	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	306	339	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	392	416	1	735	Chain	ID=PRO_0000218453;Note=Diacylglycerol kinase alpha
DGKA	P23743	91	116	110	145	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
DGKA	P23743	91	116	110	145	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
DGKA	P23743	91	116	110	145	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
DGKA	P23743	392	416	372	506	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
DGKA	P23743	392	416	372	506	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
DGKA	P23743	392	416	372	506	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
DGKA	P23743	306	339	269	319	Zinc finger	Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
DGKA	P23743	306	339	269	319	Zinc finger	Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
DGKA	P23743	306	339	269	319	Zinc finger	Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
DGKA	P23743	306	339	119	735	Alternative sequence	ID=VSP_032213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKA	P23743	392	416	119	735	Alternative sequence	ID=VSP_032213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKA	P23743	306	339	119	735	Alternative sequence	ID=VSP_032213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKA	P23743	392	416	119	735	Alternative sequence	ID=VSP_032213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKA	P23743	306	339	119	735	Alternative sequence	ID=VSP_032213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKA	P23743	392	416	119	735	Alternative sequence	ID=VSP_032213;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKA	P23743	306	339	248	735	Alternative sequence	ID=VSP_047703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DGKA	P23743	392	416	248	735	Alternative sequence	ID=VSP_047703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DGKA	P23743	306	339	248	735	Alternative sequence	ID=VSP_047703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DGKA	P23743	392	416	248	735	Alternative sequence	ID=VSP_047703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DGKA	P23743	306	339	248	735	Alternative sequence	ID=VSP_047703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DGKA	P23743	392	416	248	735	Alternative sequence	ID=VSP_047703;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DGKA	P23743	306	339	339	339	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DGKA	P23743	306	339	339	339	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DGKA	P23743	306	339	339	339	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DGKA	P23743	91	116	96	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TUZ
DGKA	P23743	91	116	96	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TUZ
DGKA	P23743	91	116	96	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TUZ
COQ7	Q99807	169	192	36	217	Chain	ID=PRO_0000079251;Note=5-demethoxyubiquinone hydroxylase%2C mitochondrial
COQ7	Q99807	169	192	36	217	Chain	ID=PRO_0000079251;Note=5-demethoxyubiquinone hydroxylase%2C mitochondrial
COQ7	Q99807	169	192	130	217	Repeat	Note=2
COQ7	Q99807	169	192	130	217	Repeat	Note=2
COQ7	Q99807	169	192	48	217	Region	Note=2 X approximate tandem repeats
COQ7	Q99807	169	192	48	217	Region	Note=2 X approximate tandem repeats
COQ7	Q99807	169	192	178	178	Metal binding	Note=Iron 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03194
COQ7	Q99807	169	192	178	178	Metal binding	Note=Iron 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03194
COQ7	Q99807	169	192	178	178	Metal binding	Note=Iron 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03194
COQ7	Q99807	169	192	178	178	Metal binding	Note=Iron 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03194
COQ7	Q99807	169	192	181	181	Metal binding	Note=Iron 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03194
COQ7	Q99807	169	192	181	181	Metal binding	Note=Iron 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03194
COQ7	Q99807	169	192	172	172	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
COQ7	Q99807	169	192	172	172	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	578	614	1	1042	Chain	ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme
CORIN	Q9Y5Q5	416	452	1	1042	Chain	ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme
CORIN	Q9Y5Q5	340	377	1	1042	Chain	ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme
CORIN	Q9Y5Q5	266	304	1	1042	Chain	ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme
CORIN	Q9Y5Q5	69	136	1	1042	Chain	ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme
CORIN	Q9Y5Q5	578	614	1	801	Chain	ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	416	452	1	801	Chain	ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	340	377	1	801	Chain	ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	266	304	1	801	Chain	ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	69	136	1	801	Chain	ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	578	614	165	801	Chain	ID=PRO_0000417984;Note=Atrial natriuretic peptide-converting enzyme%2C 160 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	416	452	165	801	Chain	ID=PRO_0000417984;Note=Atrial natriuretic peptide-converting enzyme%2C 160 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	340	377	165	801	Chain	ID=PRO_0000417984;Note=Atrial natriuretic peptide-converting enzyme%2C 160 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	266	304	165	801	Chain	ID=PRO_0000417984;Note=Atrial natriuretic peptide-converting enzyme%2C 160 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	578	614	428	801	Chain	ID=PRO_0000417985;Note=Atrial natriuretic peptide-converting enzyme%2C 100 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	416	452	428	801	Chain	ID=PRO_0000417985;Note=Atrial natriuretic peptide-converting enzyme%2C 100 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORIN	Q9Y5Q5	578	614	67	1042	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	416	452	67	1042	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	340	377	67	1042	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	266	304	67	1042	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	69	136	67	1042	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	69	136	134	259	Domain	Note=FZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00090
CORIN	Q9Y5Q5	266	304	268	304	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
CORIN	Q9Y5Q5	340	377	305	340	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
CORIN	Q9Y5Q5	340	377	341	377	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
CORIN	Q9Y5Q5	416	452	450	573	Domain	Note=FZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00090
CORIN	Q9Y5Q5	578	614	579	614	Domain	Note=LDL-receptor class A 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
CORIN	Q9Y5Q5	416	452	427	428	Site	Note=Cleavage%3B by autolysis
CORIN	Q9Y5Q5	69	136	80	80	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	69	136	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	69	136	135	135	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	340	377	376	376	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	416	452	446	446	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	416	452	451	451	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CORIN	Q9Y5Q5	266	304	269	282	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	266	304	277	295	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	266	304	289	304	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	340	377	325	340	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	340	377	342	355	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	340	377	350	368	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	340	377	362	377	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	578	614	580	592	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	578	614	587	605	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	578	614	599	614	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CORIN	Q9Y5Q5	416	452	444	444	Natural variant	ID=VAR_067796;Note=D->G;Dbxref=dbSNP:rs13105608
CORIN	Q9Y5Q5	69	136	134	134	Mutagenesis	Note=Does not affect autocatalytic cleavage. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21288900;Dbxref=PMID:21288900
CORIN	Q9Y5Q5	416	452	427	427	Mutagenesis	Note=Affects autocatalytic cleavage and production of Atrial natriuretic peptide-converting enzyme%2C 100 kDa soluble fragment. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21288900;Dbxref=PMID:21288900
DHX30	Q7L2E3	9	41	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	85	122	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	263	313	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	313	364	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	668	703	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	762	831	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	46	83	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	224	274	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	274	325	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	629	664	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	723	792	1	1194	Chain	ID=PRO_0000245538;Note=ATP-dependent RNA helicase DHX30
DHX30	Q7L2E3	85	122	53	121	Domain	Note=DRBM
DHX30	Q7L2E3	46	83	53	121	Domain	Note=DRBM
DHX30	Q7L2E3	668	703	654	827	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX30	Q7L2E3	762	831	654	827	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX30	Q7L2E3	629	664	654	827	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX30	Q7L2E3	723	792	654	827	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX30	Q7L2E3	224	274	226	226	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99PU8
DHX30	Q7L2E3	9	41	1	41	Alternative sequence	ID=VSP_022118;Note=In isoform 2. MFSLDSFRKDRAQHRQRQCKLPPPRLPPMCVNPTPGGTISR->MAAARRLMALAAGISPRLQPLGPRAAGRQGRSRGFSSSCAHPDHTKEAAEAESGMAPGGPGEGDGSLVN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DHX30	Q7L2E3	9	41	1	39	Alternative sequence	ID=VSP_036891;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DHX30	Q7L2E3	9	41	40	41	Alternative sequence	ID=VSP_036892;Note=In isoform 3. SR->MA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DHX30	Q7L2E3	762	831	781	781	Natural variant	ID=VAR_080613;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100085;Dbxref=PMID:29100085
DHX30	Q7L2E3	723	792	781	781	Natural variant	ID=VAR_080613;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100085;Dbxref=PMID:29100085
DHX30	Q7L2E3	762	831	782	782	Natural variant	ID=VAR_080614;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28327206,ECO:0000269|PubMed:29100085;Dbxref=PMID:28327206,PMID:29100085
DHX30	Q7L2E3	723	792	782	782	Natural variant	ID=VAR_080614;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28327206,ECO:0000269|PubMed:29100085;Dbxref=PMID:28327206,PMID:29100085
DHX30	Q7L2E3	762	831	785	785	Natural variant	ID=VAR_080615;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100085;Dbxref=PMID:29100085
DHX30	Q7L2E3	723	792	785	785	Natural variant	ID=VAR_080615;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100085;Dbxref=PMID:29100085
DHX30	Q7L2E3	762	831	785	785	Natural variant	ID=VAR_080616;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100085;Dbxref=PMID:29100085
DHX30	Q7L2E3	723	792	785	785	Natural variant	ID=VAR_080616;Note=In NEDMIAL%3B changed localization to stress granules%3B decreased RNA-dependent ATPase activity%3B by inducing the formation of stress granules probably indirectly decreases global protein synthesis. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100085;Dbxref=PMID:29100085
DHX30	Q7L2E3	46	83	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	46	83	53	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	46	83	67	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	46	83	74	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	85	122	81	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	46	83	81	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	85	122	93	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	85	122	97	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX30	Q7L2E3	85	122	106	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DB2
DHX37	Q8IY37	755	817	1	1157	Chain	ID=PRO_0000055172;Note=Probable ATP-dependent RNA helicase DHX37
DHX37	Q8IY37	359	397	1	1157	Chain	ID=PRO_0000055172;Note=Probable ATP-dependent RNA helicase DHX37
DHX37	Q8IY37	296	326	1	1157	Chain	ID=PRO_0000055172;Note=Probable ATP-dependent RNA helicase DHX37
DHX37	Q8IY37	359	397	262	429	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX37	Q8IY37	296	326	262	429	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX37	Q8IY37	359	397	372	375	Motif	Note=DEAH box
DHX40	Q8IX18	142	182	1	779	Chain	ID=PRO_0000252395;Note=Probable ATP-dependent RNA helicase DHX40
DHX40	Q8IX18	182	258	1	779	Chain	ID=PRO_0000252395;Note=Probable ATP-dependent RNA helicase DHX40
DHX40	Q8IX18	358	386	1	779	Chain	ID=PRO_0000252395;Note=Probable ATP-dependent RNA helicase DHX40
DHX40	Q8IX18	387	447	1	779	Chain	ID=PRO_0000252395;Note=Probable ATP-dependent RNA helicase DHX40
DHX40	Q8IX18	448	474	1	779	Chain	ID=PRO_0000252395;Note=Probable ATP-dependent RNA helicase DHX40
DHX40	Q8IX18	142	182	63	231	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX40	Q8IX18	182	258	63	231	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX40	Q8IX18	358	386	263	442	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX40	Q8IX18	387	447	263	442	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX40	Q8IX18	142	182	173	176	Motif	Note=DEAH box
DHX40	Q8IX18	142	182	66	142	Alternative sequence	ID=VSP_046973;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHX40	Q8IX18	448	474	449	449	Sequence conflict	Note=F->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHX9	Q08211	37	84	1	1270	Chain	ID=PRO_0000055157;Note=ATP-dependent RNA helicase A
DHX9	Q08211	380	444	1	1270	Chain	ID=PRO_0000055157;Note=ATP-dependent RNA helicase A
DHX9	Q08211	1087	1153	1	1270	Chain	ID=PRO_0000055157;Note=ATP-dependent RNA helicase A
DHX9	Q08211	37	84	3	71	Domain	Note=DRBM 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:23361462,ECO:0000269|PubMed:9111062;Dbxref=PMID:23361462,PMID:9111062
DHX9	Q08211	380	444	398	564	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00541,ECO:0000269|PubMed:20510246;Dbxref=PMID:20510246
DHX9	Q08211	380	444	411	419	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3LLM,ECO:0000269|PubMed:11416126,ECO:0000269|PubMed:20510246;Dbxref=PMID:11416126,PMID:20510246
DHX9	Q08211	37	84	1	250	Region	Note=Interaction with CREBBP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9323138;Dbxref=PMID:9323138
DHX9	Q08211	37	84	53	55	Region	Note=siRNA-binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3VYY,ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	380	444	255	664	Region	Note=Necessary for interaction with RNA polymerase II holoenzyme;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9323138;Dbxref=PMID:9323138
DHX9	Q08211	380	444	313	952	Region	Note=Necessary for interaction with H2AFX;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15613478;Dbxref=PMID:15613478
DHX9	Q08211	380	444	331	380	Region	Note=MTAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11416126;Dbxref=PMID:11416126
DHX9	Q08211	380	444	398	809	Region	Note=Core helicase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25062910;Dbxref=PMID:25062910
DHX9	Q08211	1087	1153	1150	1270	Region	Note=RGG;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10207077,ECO:0000269|PubMed:25062910,ECO:0000269|PubMed:25149208,ECO:0000269|PubMed:9111062;Dbxref=PMID:10207077,PMID:25062910,PMID:25149208,PMID:9111062
DHX9	Q08211	380	444	418	418	Metal binding	Note=Manganese;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3LLM,ECO:0000269|PubMed:20510246;Dbxref=PMID:20510246
DHX9	Q08211	37	84	1	1035	Alternative sequence	ID=VSP_042314;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:8690889;Dbxref=PMID:19054851,PMID:8690889
DHX9	Q08211	380	444	1	1035	Alternative sequence	ID=VSP_042314;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:8690889;Dbxref=PMID:19054851,PMID:8690889
DHX9	Q08211	37	84	53	53	Mutagenesis	Note=Inhibits siRNA-binding and decreases interaction with AGO2%3B when associated with A-54 and A-55. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	37	84	54	54	Mutagenesis	Note=Inhibits siRNA-binding and decreases interaction with AGO2%3B when associated with A-53 and A-55. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	37	84	55	55	Mutagenesis	Note=Inhibits siRNA-binding and decreases interaction with AGO2%3B when associated with A-53 and A-54. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	380	444	417	417	Mutagenesis	Note=Inhibits interaction with AGO2%2C DICER1 and TARBP2. Abrogates helicase activity and transcriptional activation. Does not inhibit binding to origins of DNA replication. K->R%2CN;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15355351,ECO:0000269|PubMed:17531811,ECO:0000269|PubMed:24990949,ECO:0000269|PubMed:9323138;Dbxref=PMID:15355351,PMID:17531811,PMID:24990949,PMID:9323138
DHX9	Q08211	380	444	417	417	Mutagenesis	Note=Reduces NUP98-induced mRNA transcription and alternative splicing activities. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28221134;Dbxref=PMID:28221134
DHX9	Q08211	1087	1153	1140	1140	Sequence conflict	Note=R->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHX9	Q08211	37	84	31	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	37	84	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	37	84	54	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	37	84	77	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	380	444	376	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	389	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	394	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	405	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	417	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	435	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	439	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
CCP110	O43303	47	90	1	1012	Chain	ID=PRO_0000089460;Note=Centriolar coiled-coil protein of 110 kDa
CCP110	O43303	828	862	1	1012	Chain	ID=PRO_0000089460;Note=Centriolar coiled-coil protein of 110 kDa
CCP110	O43303	926	946	1	1012	Chain	ID=PRO_0000089460;Note=Centriolar coiled-coil protein of 110 kDa
CCP110	O43303	47	90	1	223	Region	Note=CEP97 binding
CCP110	O43303	47	90	64	82	Region	Note=Calmodulin-binding
CCP110	O43303	47	90	67	82	Region	Note=Required for interaction with CEP290;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18694559;Dbxref=PMID:18694559
CCP110	O43303	47	90	49	90	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCP110	O43303	47	90	69	69	Natural variant	ID=VAR_056788;Note=R->S;Dbxref=dbSNP:rs16972129
C16orf89	Q6UX73	289	318	21	402	Chain	ID=PRO_0000326202;Note=UPF0764 protein C16orf89
C16orf89	Q6UX73	254	289	21	402	Chain	ID=PRO_0000326202;Note=UPF0764 protein C16orf89
C16orf89	Q6UX73	289	318	296	296	Natural variant	ID=VAR_040004;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1127920,PMID:15489334
CYP19A1	P11511	150	209	1	503	Chain	ID=PRO_0000051955;Note=Aromatase
CYP19A1	P11511	150	209	1	503	Chain	ID=PRO_0000051955;Note=Aromatase
CYP19A1	P11511	150	209	1	503	Chain	ID=PRO_0000051955;Note=Aromatase
CYP19A1	P11511	150	209	192	192	Natural variant	ID=VAR_072784;Note=In AROD%3B strongly reduced aromatase activity%3B 81%25 reduction of androstenedione metabolism compared to wild-type. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24705274;Dbxref=dbSNP:rs765057534,PMID:24705274
CYP19A1	P11511	150	209	192	192	Natural variant	ID=VAR_072784;Note=In AROD%3B strongly reduced aromatase activity%3B 81%25 reduction of androstenedione metabolism compared to wild-type. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24705274;Dbxref=dbSNP:rs765057534,PMID:24705274
CYP19A1	P11511	150	209	192	192	Natural variant	ID=VAR_072784;Note=In AROD%3B strongly reduced aromatase activity%3B 81%25 reduction of androstenedione metabolism compared to wild-type. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24705274;Dbxref=dbSNP:rs765057534,PMID:24705274
CYP19A1	P11511	150	209	201	201	Natural variant	ID=VAR_023429;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.8;Dbxref=dbSNP:rs28757184,PMID:15489334
CYP19A1	P11511	150	209	201	201	Natural variant	ID=VAR_023429;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.8;Dbxref=dbSNP:rs28757184,PMID:15489334
CYP19A1	P11511	150	209	201	201	Natural variant	ID=VAR_023429;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.8;Dbxref=dbSNP:rs28757184,PMID:15489334
CYP19A1	P11511	150	209	138	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	138	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	138	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	155	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	155	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	155	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	173	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	173	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	173	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	183	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JKW
CYP19A1	P11511	150	209	183	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JKW
CYP19A1	P11511	150	209	183	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JKW
CYP19A1	P11511	150	209	187	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	187	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP19A1	P11511	150	209	187	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S79
CYP20A1	Q6UW02	144	200	1	462	Chain	ID=PRO_0000318095;Note=Cytochrome P450 20A1
CYP20A1	Q6UW02	383	412	1	462	Chain	ID=PRO_0000318095;Note=Cytochrome P450 20A1
CYP20A1	Q6UW02	383	412	409	409	Metal binding	Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250
CYP2E1	P05181	112	162	1	493	Chain	ID=PRO_0000051751;Note=Cytochrome P450 2E1
CYP2E1	P05181	112	162	1	493	Chain	ID=PRO_0000051751;Note=Cytochrome P450 2E1
CYP2E1	P05181	112	162	112	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	112	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	122	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	122	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	142	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	142	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	160	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
CYP2E1	P05181	112	162	160	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E6I
DIP2C	Q9Y2E4	1251	1308	1	1556	Chain	ID=PRO_0000050782;Note=Disco-interacting protein 2 homolog C
DIP2C	Q9Y2E4	383	420	1	1556	Chain	ID=PRO_0000050782;Note=Disco-interacting protein 2 homolog C
DIP2C	Q9Y2E4	201	246	1	1556	Chain	ID=PRO_0000050782;Note=Disco-interacting protein 2 homolog C
DIP2C	Q9Y2E4	89	131	1	1556	Chain	ID=PRO_0000050782;Note=Disco-interacting protein 2 homolog C
DIP2C	Q9Y2E4	52	89	1	1556	Chain	ID=PRO_0000050782;Note=Disco-interacting protein 2 homolog C
DIP2C	Q9Y2E4	89	131	9	119	Domain	Note=DMAP-interaction
DIP2C	Q9Y2E4	52	89	9	119	Domain	Note=DMAP-interaction
DIP2C	Q9Y2E4	383	420	1	679	Alternative sequence	ID=VSP_056898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2C	Q9Y2E4	201	246	1	679	Alternative sequence	ID=VSP_056898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2C	Q9Y2E4	89	131	1	679	Alternative sequence	ID=VSP_056898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2C	Q9Y2E4	52	89	1	679	Alternative sequence	ID=VSP_056898;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2C	Q9Y2E4	1251	1308	1051	1556	Alternative sequence	ID=VSP_056900;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2C	Q9Y2E4	1251	1308	1264	1264	Natural variant	ID=VAR_035907;Note=In a breast cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs929297365,PMID:16959974
CYP7B1	O75881	283	352	1	506	Chain	ID=PRO_0000051906;Note=25-hydroxycholesterol 7-alpha-hydroxylase
CYP7B1	O75881	283	352	285	285	Natural variant	ID=VAR_075510;Note=In SPG5A. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21214876;Dbxref=dbSNP:rs750781606,PMID:21214876
CYP7B1	O75881	283	352	287	287	Natural variant	ID=VAR_075511;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19439420;Dbxref=PMID:19439420
CYP7B1	O75881	283	352	297	297	Natural variant	ID=VAR_075512;Note=In SPG5A. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19439420,ECO:0000269|PubMed:21214876;Dbxref=dbSNP:rs587777222,PMID:19439420,PMID:21214876
CYP7B1	O75881	283	352	316	316	Natural variant	ID=VAR_075513;Note=In SPG5A%3B unknown pathological significance. A->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24117163;Dbxref=PMID:24117163
CYP7B1	O75881	283	352	324	324	Natural variant	ID=VAR_075514;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19439420,ECO:0000269|PubMed:26714052;Dbxref=dbSNP:rs59035258,PMID:19439420,PMID:26714052
CYP4A22	Q5TCH4	112	127	5	519	Chain	ID=PRO_0000343409;Note=Cytochrome P450 4A22
CYP4A22	Q5TCH4	112	127	121	121	Natural variant	ID=VAR_044350;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10860550;Dbxref=dbSNP:rs2758717,PMID:10860550
CYP4A22	Q5TCH4	112	127	126	126	Natural variant	ID=VAR_044351;Note=In allele CYP4A22*8%2C allele CYP4A22*9%2C allele CYP4A22*11%2C allele CYP4A22*12%2C allele CYP4A22*13%2C allele CYP4A22*14 and allele CYP4A22*15. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15611369,ECO:0000269|PubMed:16806293;Dbxref=dbSNP:rs12564525,PMID:15611369,PMID:16806293
CYP4A22	Q5TCH4	112	127	114	114	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPEB3	Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
CPEB3	Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
CPEB3	Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CPEB3	Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CPEB3	Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7TN99
CPEB3	Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
CPEB3	Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RUG
CPEB3	Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RUG
CPEB4	Q17RY0	402	419	1	729	Chain	ID=PRO_0000269264;Note=Cytoplasmic polyadenylation element-binding protein 4
CPEB4	Q17RY0	402	419	403	419	Alternative sequence	ID=VSP_022041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334
CPEB4	Q17RY0	402	419	404	428	Alternative sequence	ID=VSP_022042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CPPED1	Q9BRF8	96	238	1	314	Chain	ID=PRO_0000320556;Note=Serine/threonine-protein phosphatase CPPED1
CPPED1	Q9BRF8	96	238	47	250	Region	Note=Catalytic
CPPED1	Q9BRF8	96	238	127	127	Metal binding	Note=Divalent metal cation 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPPED1	Q9BRF8	96	238	97	238	Alternative sequence	ID=VSP_031658;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPPED1	Q9BRF8	96	238	97	122	Alternative sequence	ID=VSP_055218;Note=In isoform 3. GKPWRTEQTEDLKRVLRAVDRAIPLV->AGQRPPRAPSRGGHRRENCSPILQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPPED1	Q9BRF8	96	238	123	314	Alternative sequence	ID=VSP_055219;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPPED1	Q9BRF8	96	238	148	148	Sequence conflict	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPPED1	Q9BRF8	96	238	230	230	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
NUDT21	O43809	127	157	2	227	Chain	ID=PRO_0000057150;Note=Cleavage and polyadenylation specificity factor subunit 5
NUDT21	O43809	127	157	76	201	Domain	Note=Nudix hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00794
NUDT21	O43809	127	157	2	147	Region	Note=Necessary for RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15169763;Dbxref=PMID:15169763
NUDT21	O43809	127	157	81	160	Region	Note=Necessary for interactions with PAPOLA and PABPN1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15169763;Dbxref=PMID:15169763
NUDT21	O43809	127	157	109	130	Motif	Note=Nudix box
NUDT21	O43809	127	157	154	154	Mutagenesis	Note=Reduces affinity for UGUA RNA by 50%25. E->A
NUDT21	O43809	127	157	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BHO
NUDT21	O43809	127	157	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N9U
NUDT21	O43809	127	157	140	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BHO
NUDT21	O43809	127	157	152	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BHO
CPSF2	Q9P2I0	481	531	1	782	Chain	ID=PRO_0000074393;Note=Cleavage and polyadenylation specificity factor subunit 2
CPSF2	Q9P2I0	607	707	1	782	Chain	ID=PRO_0000074393;Note=Cleavage and polyadenylation specificity factor subunit 2
CPSF2	Q9P2I0	607	707	660	660	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CPSF2	Q9P2I0	607	707	654	654	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPSF4	O95639	51	102	1	269	Chain	ID=PRO_0000074402;Note=Cleavage and polyadenylation specificity factor subunit 4
CPSF4	O95639	102	134	1	269	Chain	ID=PRO_0000074402;Note=Cleavage and polyadenylation specificity factor subunit 4
CPSF4	O95639	51	102	35	61	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CPSF4	O95639	51	102	62	89	Zinc finger	Note=C3H1-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CPSF4	O95639	51	102	90	117	Zinc finger	Note=C3H1-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CPSF4	O95639	102	134	90	117	Zinc finger	Note=C3H1-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CPSF4	O95639	102	134	118	142	Zinc finger	Note=C3H1-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CPSF4	O95639	51	102	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FBS
CPSF4	O95639	51	102	69	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RHK
CPSF4	O95639	51	102	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RHK
CPSF4	O95639	51	102	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RHK
CPSF4	O95639	51	102	90	92	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9N
CPSF4	O95639	51	102	97	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RHK
CPSF4	O95639	102	134	97	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RHK
CPSF4	O95639	102	134	111	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9N
CPSF4	O95639	102	134	122	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9N
CPT1C	Q8TCG5	151	185	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	483	522	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	522	577	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	577	622	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	622	673	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	673	711	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	151	185	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	483	522	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	522	577	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	577	622	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	622	673	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	673	711	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	151	185	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	483	522	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	522	577	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	577	622	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	622	673	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	673	711	1	803	Chain	ID=PRO_0000210166;Note=Carnitine O-palmitoyltransferase 1%2C brain isoform
CPT1C	Q8TCG5	151	185	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	483	522	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	522	577	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	577	622	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	622	673	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	673	711	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	151	185	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	483	522	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	522	577	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	577	622	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	622	673	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	673	711	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	151	185	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	483	522	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	522	577	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	577	622	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	622	673	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	673	711	127	803	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1C	Q8TCG5	522	577	552	564	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	522	577	552	564	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	522	577	552	564	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	586	586	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	586	586	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	586	586	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	588	588	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	588	588	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	588	588	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	599	599	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	599	599	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	577	622	599	599	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1C	Q8TCG5	622	673	623	711	Alternative sequence	ID=VSP_012457;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPT1C	Q8TCG5	673	711	623	711	Alternative sequence	ID=VSP_012457;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPT1C	Q8TCG5	622	673	623	711	Alternative sequence	ID=VSP_012457;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPT1C	Q8TCG5	673	711	623	711	Alternative sequence	ID=VSP_012457;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPT1C	Q8TCG5	622	673	623	711	Alternative sequence	ID=VSP_012457;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPT1C	Q8TCG5	673	711	623	711	Alternative sequence	ID=VSP_012457;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CPT1C	Q8TCG5	522	577	542	542	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPT1C	Q8TCG5	522	577	542	542	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPT1C	Q8TCG5	522	577	542	542	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
C17orf80	Q9BSJ5	504	540	1	609	Chain	ID=PRO_0000284612;Note=Uncharacterized protein C17orf80
C17orf80	Q9BSJ5	504	540	1	609	Chain	ID=PRO_0000284612;Note=Uncharacterized protein C17orf80
C17orf80	Q9BSJ5	504	540	1	552	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
C17orf80	Q9BSJ5	504	540	1	552	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
C17orf80	Q9BSJ5	504	540	505	540	Alternative sequence	ID=VSP_024572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:11230166,PMID:14702039
C17orf80	Q9BSJ5	504	540	505	540	Alternative sequence	ID=VSP_024572;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.1;Dbxref=PMID:11230166,PMID:14702039
C17orf80	Q9BSJ5	504	540	522	522	Natural variant	ID=VAR_031785;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.1;Dbxref=dbSNP:rs1566286,PMID:14702039
C17orf80	Q9BSJ5	504	540	522	522	Natural variant	ID=VAR_031785;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.1;Dbxref=dbSNP:rs1566286,PMID:14702039
C17orf80	Q9BSJ5	504	540	536	536	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
C17orf80	Q9BSJ5	504	540	536	536	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CREB3L3	Q68CJ9	192	238	1	461	Chain	ID=PRO_0000288074;Note=Cyclic AMP-responsive element-binding protein 3-like protein 3
CREB3L3	Q68CJ9	274	296	1	461	Chain	ID=PRO_0000288074;Note=Cyclic AMP-responsive element-binding protein 3-like protein 3
CREB3L3	Q68CJ9	192	238	1	322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CREB3L3	Q68CJ9	274	296	1	322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CREB3L3	Q68CJ9	274	296	243	306	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
CREB3L3	Q68CJ9	274	296	245	274	Region	Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
CREB3L3	Q68CJ9	274	296	285	306	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
CREB3L3	Q68CJ9	192	238	193	194	Alternative sequence	ID=VSP_054876;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CREB3L3	Q68CJ9	274	296	239	337	Alternative sequence	ID=VSP_055635;Note=In isoform 4. YEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAVLLLSFALIILP->DVSLHCSESGVTEESLASREAKPVPLGATEETPGHCGAVHQQVSPDRHLCRSPVAVLCPHHPPLHQPFWPQQNREPWGLCACTSVLQNFAQRCCLPRGC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHRDL2	Q6WN34	250	315	26	429	Chain	ID=PRO_0000005371;Note=Chordin-like protein 2
CHRDL2	Q6WN34	250	315	250	315	Domain	Note=VWFC 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CHRDL2	Q6WN34	250	315	114	429	Alternative sequence	ID=VSP_013516;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15094188;Dbxref=PMID:15094188
CHRDL2	Q6WN34	250	315	163	429	Alternative sequence	ID=VSP_013518;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15094188;Dbxref=PMID:15094188
MCC	P23508	626	695	1	829	Chain	ID=PRO_0000079333;Note=Colorectal mutant cancer protein
DNAJC16	Q9Y2G8	253	288	26	782	Chain	ID=PRO_0000236683;Note=DnaJ homolog subfamily C member 16
DNAJC16	Q9Y2G8	288	341	26	782	Chain	ID=PRO_0000236683;Note=DnaJ homolog subfamily C member 16
DNAJC16	Q9Y2G8	253	288	26	535	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAJC16	Q9Y2G8	288	341	26	535	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAJC16	Q9Y2G8	253	288	1	312	Alternative sequence	ID=VSP_018583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DNAJC16	Q9Y2G8	288	341	1	312	Alternative sequence	ID=VSP_018583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CRTC2	Q53ET0	468	558	2	693	Chain	ID=PRO_0000318528;Note=CREB-regulated transcription coactivator 2
CRTC2	Q53ET0	145	167	2	693	Chain	ID=PRO_0000318528;Note=CREB-regulated transcription coactivator 2
CRTC2	Q53ET0	51	85	2	693	Chain	ID=PRO_0000318528;Note=CREB-regulated transcription coactivator 2
CRTC2	Q53ET0	51	85	51	51	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3U182
CRTC2	Q53ET0	51	85	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:15454081;Dbxref=PMID:18669648,PMID:19690332,PMID:15454081
CRTC2	Q53ET0	145	167	161	161	Modified residue	Note=Asymmetric dimethylarginine%3B by PRMT6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3U182
CRTC2	Q53ET0	468	558	488	488	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
CRTC2	Q53ET0	468	558	489	489	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15454081;Dbxref=PMID:15454081
CRTC2	Q53ET0	468	558	490	490	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
CRTC2	Q53ET0	468	558	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15454081;Dbxref=PMID:15454081
CRTC2	Q53ET0	468	558	501	501	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
CRTC2	Q53ET0	145	167	147	147	Natural variant	ID=VAR_038756;Note=M->V;Dbxref=dbSNP:rs11264680
CRTC2	Q53ET0	51	85	70	70	Mutagenesis	Note=No effect on cAMP- and calcium-regulated phosphorylation. S->A
CRTC2	Q53ET0	468	558	499	499	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
COQ5	Q5HYK3	117	191	43	327	Chain	ID=PRO_0000228628;Note=2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase%2C mitochondrial
COQ5	Q5HYK3	117	191	117	117	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03191
COQ5	Q5HYK3	117	191	171	171	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03191
COQ5	Q5HYK3	117	191	119	170	Alternative sequence	ID=VSP_017681;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COQ5	Q5HYK3	117	191	189	327	Alternative sequence	ID=VSP_017682;Note=In isoform 2. YRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL->HDRRCRLSQGDLRKSNIRHCGHSFWLQTLIPFLSWSMNQSYPVESLELKDNLANETAAEHLLLRIRALDSCLNRTVSKWKNKFLSLFYSFLWSCFSPSPRGIWSVSLLNC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COQ5	Q5HYK3	117	191	152	152	Natural variant	ID=VAR_025702;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:25152161,ECO:0000269|Ref.3;Dbxref=dbSNP:rs3742049,PMID:15489334,PMID:25152161
COQ5	Q5HYK3	117	191	171	171	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CMC1	Q7Z7K0	6	36	2	106	Chain	ID=PRO_0000317185;Note=COX assembly mitochondrial protein homolog
CMC1	Q7Z7K0	6	36	28	71	Domain	Note=CHCH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC1	Q7Z7K0	6	36	31	41	Motif	Note=Cx9C motif 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC1	Q7Z7K0	6	36	31	63	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU01150,ECO:0000305|PubMed:23676665;Dbxref=PMID:23676665
DHX8	Q14562	834	881	1	1220	Chain	ID=PRO_0000055131;Note=ATP-dependent RNA helicase DHX8
DHX8	Q14562	979	1022	1	1220	Chain	ID=PRO_0000055131;Note=ATP-dependent RNA helicase DHX8
DHX8	Q14562	834	881	756	936	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX8	Q14562	979	1022	975	980	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4U
DHX8	Q14562	979	1022	987	998	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4U
DHX8	Q14562	979	1022	1002	1012	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4U
DHX8	Q14562	979	1022	1022	1024	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4U
DHPS	P49366	296	338	1	369	Chain	ID=PRO_0000134469;Note=Deoxyhypusine synthase
DHPS	P49366	197	226	1	369	Chain	ID=PRO_0000134469;Note=Deoxyhypusine synthase
DHPS	P49366	296	338	308	309	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9493264;Dbxref=PMID:9493264
DHPS	P49366	296	338	314	316	Region	Note=Spermidine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	323	329	Region	Note=Spermidine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	329	329	Active site	Note=Nucleophile;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9405486;Dbxref=PMID:9405486
DHPS	P49366	296	338	262	308	Alternative sequence	ID=VSP_001351;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8615810;Dbxref=PMID:8615810
DHPS	P49366	296	338	305	305	Mutagenesis	Note=Strongly reduced NAD binding. No effect on enzyme activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	313	313	Mutagenesis	Note=Strongly reduced NAD binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	316	316	Mutagenesis	Note=Reduces spermidine binding by 98%25. Loss of covalent intermediate formation and deoxyhypusine synthesis. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	317	317	Mutagenesis	Note=Strongly reduced NAD binding. No effect on enzyme activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	323	323	Mutagenesis	Note=Reduces spermidine binding by 98%25. Strongly reduced formation of covalent intermediate. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	327	327	Mutagenesis	Note=Reduces spermidine binding by 98%25. Loss of covalent intermediate formation and deoxyhypusine synthesis. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	329	329	Mutagenesis	Note=Loss of covalent intermediate formation and deoxyhypusine synthesis. K->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9405486;Dbxref=PMID:9405486
DHPS	P49366	197	226	199	199	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	199	199	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	220	220	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	220	220	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	296	297	Sequence conflict	Note=MR->SG;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	311	311	Sequence conflict	Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	203	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	197	226	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	299	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	321	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	337	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DIS3L	Q8TF46	98	140	1	1054	Chain	ID=PRO_0000314810;Note=DIS3-like exonuclease 1
DIS3L	Q8TF46	186	245	1	1054	Chain	ID=PRO_0000314810;Note=DIS3-like exonuclease 1
DIS3L	Q8TF46	525	555	1	1054	Chain	ID=PRO_0000314810;Note=DIS3-like exonuclease 1
DIS3L	Q8TF46	556	733	1	1054	Chain	ID=PRO_0000314810;Note=DIS3-like exonuclease 1
DIS3L	Q8TF46	98	140	1	134	Alternative sequence	ID=VSP_030366;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11853319;Dbxref=PMID:11853319
DIS3L	Q8TF46	556	733	614	614	Natural variant	ID=VAR_038057;Note=D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3803412,PMID:14702039,PMID:15489334
C16orf87	Q6PH81	54	115	1	154	Chain	ID=PRO_0000326521;Note=UPF0547 protein C16orf87
C16orf87	Q6PH81	54	115	104	132	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
C16orf87	Q6PH81	54	115	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
C16orf87	Q6PH81	54	115	55	115	Alternative sequence	ID=VSP_032670;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIAPH1	O60610	889	923	1	1272	Chain	ID=PRO_0000194893;Note=Protein diaphanous homolog 1
DIAPH1	O60610	100	134	1	1272	Chain	ID=PRO_0000194893;Note=Protein diaphanous homolog 1
DIAPH1	O60610	100	134	84	449	Domain	Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579
DIAPH1	O60610	889	923	769	1171	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
DIMT1	Q9UNQ2	51	80	1	313	Chain	ID=PRO_0000101465;Note=Probable dimethyladenosine transferase
DIMT1	Q9UNQ2	51	80	64	64	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01026,ECO:0000269|Ref.9
DIMT1	Q9UNQ2	51	80	42	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZQ9
DIMT1	Q9UNQ2	51	80	59	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZQ9
DIMT1	Q9UNQ2	51	80	71	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZQ9
DIMT1	Q9UNQ2	51	80	78	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZQ9
CYP24A1	Q07973	412	478	36	514	Chain	ID=PRO_0000003615;Note=1%2C25-dihydroxyvitamin D(3) 24-hydroxylase%2C mitochondrial
CYP24A1	Q07973	412	478	462	462	Metal binding	Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250
CYP24A1	Q07973	412	478	413	478	Alternative sequence	ID=VSP_043101;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP250	Q9BV73	62	81	1	2442	Chain	ID=PRO_0000089487;Note=Centrosome-associated protein CEP250
CEP250	Q9BV73	621	698	1	2442	Chain	ID=PRO_0000089487;Note=Centrosome-associated protein CEP250
CEP250	Q9BV73	862	918	1	2442	Chain	ID=PRO_0000089487;Note=Centrosome-associated protein CEP250
CEP250	Q9BV73	963	1011	1	2442	Chain	ID=PRO_0000089487;Note=Centrosome-associated protein CEP250
CEP250	Q9BV73	2212	2250	1	2442	Chain	ID=PRO_0000089487;Note=Centrosome-associated protein CEP250
CEP250	Q9BV73	2302	2336	1	2442	Chain	ID=PRO_0000089487;Note=Centrosome-associated protein CEP250
CEP250	Q9BV73	621	698	395	1172	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP250	Q9BV73	862	918	395	1172	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP250	Q9BV73	963	1011	395	1172	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP250	Q9BV73	2212	2250	1243	2227	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP250	Q9BV73	2302	2336	2262	2376	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP250	Q9BV73	621	698	464	2171	Compositional bias	Note=Gln/Glu-rich
CEP250	Q9BV73	862	918	464	2171	Compositional bias	Note=Gln/Glu-rich
CEP250	Q9BV73	963	1011	464	2171	Compositional bias	Note=Gln/Glu-rich
CEP250	Q9BV73	2212	2250	2218	2218	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CEP250	Q9BV73	2212	2250	2229	2229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
CEP250	Q9BV73	2302	2336	2322	2322	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CEP250	Q9BV73	862	918	863	918	Alternative sequence	ID=VSP_007372;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9647649;Dbxref=PMID:9647649
CEP250	Q9BV73	963	1011	995	995	Natural variant	ID=VAR_015649;Note=Q->H;Dbxref=dbSNP:rs2296403
CYP2C18	P33260	214	273	1	490	Chain	ID=PRO_0000051707;Note=Cytochrome P450 2C18
CYP2C18	P33260	214	273	214	272	Alternative sequence	ID=VSP_042520;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIP2A	Q14689	30	54	1	1571	Chain	ID=PRO_0000079906;Note=Disco-interacting protein 2 homolog A
DIP2A	Q14689	54	94	1	1571	Chain	ID=PRO_0000079906;Note=Disco-interacting protein 2 homolog A
DIP2A	Q14689	134	218	1	1571	Chain	ID=PRO_0000079906;Note=Disco-interacting protein 2 homolog A
DIP2A	Q14689	218	261	1	1571	Chain	ID=PRO_0000079906;Note=Disco-interacting protein 2 homolog A
DIP2A	Q14689	600	640	1	1571	Chain	ID=PRO_0000079906;Note=Disco-interacting protein 2 homolog A
DIP2A	Q14689	30	54	10	122	Domain	Note=DMAP-interaction
DIP2A	Q14689	54	94	10	122	Domain	Note=DMAP-interaction
DIP2A	Q14689	54	94	94	94	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DIP2A	Q14689	134	218	155	155	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DIP2A	Q14689	30	54	31	94	Alternative sequence	ID=VSP_045408;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2A	Q14689	54	94	31	94	Alternative sequence	ID=VSP_045408;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2A	Q14689	218	261	219	261	Alternative sequence	ID=VSP_007748;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIP2A	Q14689	134	218	191	191	Natural variant	ID=VAR_047372;Note=P->A;Dbxref=dbSNP:rs7283507
CYP2W1	Q8TAV3	215	273	23	490	Chain	ID=PRO_0000051782;Note=Cytochrome P450 2W1;Ontology_term=ECO:0000255;evidence=ECO:0000255
CYP4Z1	Q86W10	106	121	1	505	Chain	ID=PRO_0000051864;Note=Cytochrome P450 4Z1
CYP4Z1	Q86W10	106	121	31	505	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPAMD8	Q8IZJ3	1735	1805	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	1638	1663	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	1516	1537	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	1389	1418	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	1309	1334	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	683	737	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	633	683	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	469	512	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	412	469	26	1885	Chain	ID=PRO_0000317695;Note=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
CPAMD8	Q8IZJ3	1735	1805	1706	1757	Domain	Note=Kazal-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
CPAMD8	Q8IZJ3	633	683	668	671	Compositional bias	Note=Poly-Arg
CPAMD8	Q8IZJ3	1735	1805	1765	1768	Compositional bias	Note=Poly-Ser
CPAMD8	Q8IZJ3	633	683	671	672	Site	Note=Cleavage%3B by furin-like protease;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPAMD8	Q8IZJ3	1735	1805	1712	1742	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
CPAMD8	Q8IZJ3	1735	1805	1716	1735	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
CPAMD8	Q8IZJ3	1735	1805	1724	1755	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798
CPAMD8	Q8IZJ3	683	737	736	736	Natural variant	ID=VAR_038660;Note=P->H;Dbxref=dbSNP:rs9305083
CPAMD8	Q8IZJ3	1389	1418	1404	1404	Natural variant	ID=VAR_077933;Note=In ASGD8. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839872;Dbxref=PMID:27839872
CPVL	Q9H3G5	379	440	388	388	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10074
CPVL	Q9H3G5	379	440	388	388	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10074
CPVL	Q9H3G5	379	440	388	388	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10074
CPVL	Q9H3G5	288	321	307	307	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPVL	Q9H3G5	288	321	307	307	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPVL	Q9H3G5	288	321	307	307	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPVL	Q9H3G5	321	379	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CPVL	Q9H3G5	321	379	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CPVL	Q9H3G5	321	379	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CPVL	Q9H3G5	379	440	398	398	Natural variant	ID=VAR_048683;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11401439,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1052200,PMID:11401439
CPVL	Q9H3G5	379	440	398	398	Natural variant	ID=VAR_048683;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11401439,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1052200,PMID:11401439
CPVL	Q9H3G5	379	440	398	398	Natural variant	ID=VAR_048683;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11401439,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1052200,PMID:11401439
CPVL	Q9H3G5	379	440	435	435	Natural variant	ID=VAR_022612;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs7313,PMID:15489334,PMID:16303743
CPVL	Q9H3G5	379	440	435	435	Natural variant	ID=VAR_022612;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs7313,PMID:15489334,PMID:16303743
CPVL	Q9H3G5	379	440	435	435	Natural variant	ID=VAR_022612;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs7313,PMID:15489334,PMID:16303743
CPVL	Q9H3G5	379	440	422	422	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPVL	Q9H3G5	379	440	422	422	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPVL	Q9H3G5	379	440	422	422	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPVL	Q9H3G5	379	440	438	438	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPVL	Q9H3G5	379	440	438	438	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPVL	Q9H3G5	379	440	438	438	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPT1A	P50416	714	745	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	625	676	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	580	625	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	257	293	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	231	257	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	151	185	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	714	745	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	625	676	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	580	625	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	257	293	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	231	257	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	151	185	2	773	Chain	ID=PRO_0000210159;Note=Carnitine O-palmitoyltransferase 1%2C liver isoform
CPT1A	P50416	714	745	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	625	676	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	580	625	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	257	293	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	231	257	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	151	185	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	714	745	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	625	676	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	580	625	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	257	293	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	231	257	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	151	185	123	773	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1A	P50416	580	625	589	589	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1A	P50416	580	625	589	589	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1A	P50416	580	625	602	602	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1A	P50416	580	625	602	602	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT1A	P50416	257	293	282	282	Modified residue	Note=Nitrated tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	257	293	282	282	Modified residue	Note=Nitrated tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	580	625	588	588	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	580	625	588	588	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	580	625	589	589	Modified residue	Note=Nitrated tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	580	625	589	589	Modified residue	Note=Nitrated tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	580	625	604	604	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	580	625	604	604	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	714	745	741	741	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	714	745	741	741	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32198
CPT1A	P50416	257	293	275	275	Natural variant	ID=VAR_020547;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11441142,ECO:0000269|PubMed:12189492,ECO:0000269|PubMed:14517221;Dbxref=dbSNP:rs2229738,PMID:11441142,PMID:12189492,PMID:14517221
CPT1A	P50416	257	293	275	275	Natural variant	ID=VAR_020547;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11441142,ECO:0000269|PubMed:12189492,ECO:0000269|PubMed:14517221;Dbxref=dbSNP:rs2229738,PMID:11441142,PMID:12189492,PMID:14517221
CPXM2	Q8N436	433	493	26	756	Chain	ID=PRO_0000004409;Note=Inactive carboxypeptidase-like protein X2
CPXM2	Q8N436	101	134	26	756	Chain	ID=PRO_0000004409;Note=Inactive carboxypeptidase-like protein X2
CPXM2	Q8N436	101	134	134	293	Domain	Note=F5/8 type C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081
CPXM2	Q8N436	101	134	45	101	Compositional bias	Note=Pro-rich
CPXM2	Q8N436	433	493	491	491	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COQ10B	Q9H8M1	149	183	38	238	Chain	ID=PRO_0000228647;Note=Coenzyme Q-binding protein COQ10 homolog B%2C mitochondrial
CRTAC1	Q9NQ79	558	606	28	661	Chain	ID=PRO_0000007497;Note=Cartilage acidic protein 1
CRTAC1	Q9NQ79	558	606	559	605	Domain	Note=EGF-like
CRTAC1	Q9NQ79	558	606	563	577	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CRTAC1	Q9NQ79	558	606	570	586	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CRTAC1	Q9NQ79	558	606	592	605	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CRTAC1	Q9NQ79	558	606	545	661	Alternative sequence	ID=VSP_010893;Note=In isoform 3. CGQGFSQQENGHCMDTNECIQFPFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAAATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPSC->TPMNASSSHSCALETSPYVSTPMEATGAGPTRSAVGATSPTRMAQPAWGLSASHRAPAPPPPPLLLPLPLLLPLLELPLLHRSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CRTAC1	Q9NQ79	558	606	569	569	Natural variant	ID=VAR_048973;Note=V->M;Dbxref=dbSNP:rs2297935
CRIM1	Q9NZV1	168	249	35	1036	Chain	ID=PRO_0000021001;Note=Cysteine-rich motor neuron 1 protein
CRIM1	Q9NZV1	593	663	35	1036	Chain	ID=PRO_0000021001;Note=Cysteine-rich motor neuron 1 protein
CRIM1	Q9NZV1	735	809	35	1036	Chain	ID=PRO_0000021001;Note=Cysteine-rich motor neuron 1 protein
CRIM1	Q9NZV1	809	874	35	1036	Chain	ID=PRO_0000021001;Note=Cysteine-rich motor neuron 1 protein
CRIM1	Q9NZV1	168	249	35	939	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRIM1	Q9NZV1	593	663	35	939	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRIM1	Q9NZV1	735	809	35	939	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRIM1	Q9NZV1	809	874	35	939	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRIM1	Q9NZV1	593	663	606	663	Domain	Note=VWFC 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CRIM1	Q9NZV1	735	809	677	735	Domain	Note=VWFC 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CRIM1	Q9NZV1	735	809	751	809	Domain	Note=VWFC 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CRIM1	Q9NZV1	809	874	751	809	Domain	Note=VWFC 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CRIM1	Q9NZV1	809	874	817	874	Domain	Note=VWFC 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CRIM1	Q9NZV1	735	809	746	746	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRIM1	Q9NZV1	735	809	781	781	Natural variant	ID=VAR_061625;Note=V->I;Dbxref=dbSNP:rs59929305
CRHR1	P34998	40	80	24	444	Chain	ID=PRO_0000012814;Note=Corticotropin-releasing factor receptor 1
CRHR1	P34998	145	173	24	444	Chain	ID=PRO_0000012814;Note=Corticotropin-releasing factor receptor 1
CRHR1	P34998	384	398	24	444	Chain	ID=PRO_0000012814;Note=Corticotropin-releasing factor receptor 1
CRHR1	P34998	40	80	24	111	Topological domain	Note=Extracellular
CRHR1	P34998	145	173	143	178	Topological domain	Note=Cytoplasmic
CRHR1	P34998	384	398	368	397	Transmembrane	Note=Helical%3B Name%3D7
CRHR1	P34998	384	398	398	444	Topological domain	Note=Cytoplasmic
CRHR1	P34998	40	80	45	45	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRHR1	P34998	40	80	78	78	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRHR1	P34998	40	80	30	54	Disulfide bond	.
CRHR1	P34998	40	80	44	87	Disulfide bond	.
CRHR1	P34998	40	80	68	102	Disulfide bond	.
CRHR1	P34998	40	80	1	204	Alternative sequence	ID=VSP_045434;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.6;Dbxref=PMID:14702039
CRHR1	P34998	145	173	1	204	Alternative sequence	ID=VSP_045434;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.6;Dbxref=PMID:14702039
CRHR1	P34998	40	80	41	81	Alternative sequence	ID=VSP_001996;Note=In isoform CRF-R3. GLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7811272;Dbxref=PMID:7811272
CRHR1	P34998	145	173	146	174	Alternative sequence	ID=VSP_001997;Note=In isoform CRF-R2%2C isoform CRF-R3 and isoform CRF-R4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10598591,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:7692441,ECO:0000303|PubMed:7811272,ECO:0000303|PubMed:8243652,ECO:0000303|Ref.7;Dbxref=PMID:10598591,PMID:15489334,PMID:19054851,PMID:7692441,PMID:7811272,PMID:8243652
CRHR1	P34998	384	398	385	398	Alternative sequence	ID=VSP_001998;Note=In isoform CRF-R4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10598591;Dbxref=PMID:10598591
CRHR1	P34998	384	398	384	384	Mutagenesis	Note=Increases antagonist binding. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23863939;Dbxref=PMID:23863939
CRHR1	P34998	40	80	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L27
CRHR1	P34998	40	80	62	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHU
CRHR1	P34998	40	80	70	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHU
CRHR1	P34998	384	398	368	396	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K5Y
CRIP3	Q6Q6R5	109	133	1	217	Chain	ID=PRO_0000225638;Note=Cysteine-rich protein 3
CRIP3	Q6Q6R5	109	133	122	183	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
DKK3	Q9UBP4	117	145	22	350	Chain	ID=PRO_0000007222;Note=Dickkopf-related protein 3
DKK3	Q9UBP4	117	145	22	350	Chain	ID=PRO_0000007222;Note=Dickkopf-related protein 3
DKK3	Q9UBP4	117	145	121	121	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DKK3	Q9UBP4	117	145	121	121	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DKKL1	Q9UK85	61	108	31	242	Chain	ID=PRO_0000007228;Note=Dickkopf-like protein 1
DKKL1	Q9UK85	108	139	31	242	Chain	ID=PRO_0000007228;Note=Dickkopf-like protein 1
DKKL1	Q9UK85	61	108	97	97	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DKKL1	Q9UK85	108	139	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DKKL1	Q9UK85	61	108	104	104	Natural variant	ID=VAR_053062;Note=L->I;Dbxref=dbSNP:rs35693137
DKKL1	Q9UK85	108	139	109	109	Natural variant	ID=VAR_021967;Note=M->R;Dbxref=dbSNP:rs2303759
CRTC3	Q6UUV7	44	77	1	619	Chain	ID=PRO_0000318531;Note=CREB-regulated transcription coactivator 3
CRTC3	Q6UUV7	192	204	1	619	Chain	ID=PRO_0000318531;Note=CREB-regulated transcription coactivator 3
CRTC3	Q6UUV7	44	77	1	103	Region	Note=Required for interaction with HTLV-1 TAX
CRTC3	Q6UUV7	44	77	62	62	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
CRTC3	Q6UUV7	44	77	72	72	Natural variant	ID=VAR_038758;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12693554,ECO:0000269|PubMed:14506290;Dbxref=dbSNP:rs8033595,PMID:12693554,PMID:14506290
CRY1	Q16526	528	552	1	586	Chain	ID=PRO_0000261140;Note=Cryptochrome-1
CRYAB	P02511	67	108	1	175	Chain	ID=PRO_0000125907;Note=Alpha-crystallin B chain
CRYAB	P02511	67	108	1	175	Chain	ID=PRO_0000125907;Note=Alpha-crystallin B chain
CRYAB	P02511	67	108	1	175	Chain	ID=PRO_0000125907;Note=Alpha-crystallin B chain
CRYAB	P02511	67	108	1	175	Chain	ID=PRO_0000125907;Note=Alpha-crystallin B chain
CRYAB	P02511	67	108	56	164	Domain	Note=sHSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00285
CRYAB	P02511	67	108	56	164	Domain	Note=sHSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00285
CRYAB	P02511	67	108	56	164	Domain	Note=sHSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00285
CRYAB	P02511	67	108	56	164	Domain	Note=sHSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00285
CRYAB	P02511	67	108	83	83	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	83	83	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	83	83	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	83	83	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	104	104	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRYAB	P02511	67	108	104	104	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRYAB	P02511	67	108	104	104	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRYAB	P02511	67	108	104	104	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRYAB	P02511	67	108	106	106	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	106	106	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	106	106	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	106	106	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CRYAB	P02511	67	108	68	68	Site	Note=Susceptible to oxidation
CRYAB	P02511	67	108	68	68	Site	Note=Susceptible to oxidation
CRYAB	P02511	67	108	68	68	Site	Note=Susceptible to oxidation
CRYAB	P02511	67	108	68	68	Site	Note=Susceptible to oxidation
CRYAB	P02511	67	108	92	92	Modified residue	Note=N6-acetyllysine%3B partial;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11369851,ECO:0000269|PubMed:22120592;Dbxref=PMID:11369851,PMID:22120592
CRYAB	P02511	67	108	92	92	Modified residue	Note=N6-acetyllysine%3B partial;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11369851,ECO:0000269|PubMed:22120592;Dbxref=PMID:11369851,PMID:22120592
CRYAB	P02511	67	108	92	92	Modified residue	Note=N6-acetyllysine%3B partial;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11369851,ECO:0000269|PubMed:22120592;Dbxref=PMID:11369851,PMID:22120592
CRYAB	P02511	67	108	92	92	Modified residue	Note=N6-acetyllysine%3B partial;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11369851,ECO:0000269|PubMed:22120592;Dbxref=PMID:11369851,PMID:22120592
CRYAB	P02511	67	108	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	72	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	72	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	72	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	72	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N0K
CRYAB	P02511	67	108	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N0K
CRYAB	P02511	67	108	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N0K
CRYAB	P02511	67	108	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N0K
CRYAB	P02511	67	108	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	86	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	89	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	89	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	89	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	89	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	97	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	97	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	97	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
CRYAB	P02511	67	108	97	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M5S
TMEM63B	Q5T3F8	80	92	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	261	287	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	507	535	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	536	557	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	647	703	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	80	92	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	261	287	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	507	535	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	536	557	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	647	703	1	832	Chain	ID=PRO_0000280728;Note=CSC1-like protein 2
TMEM63B	Q5T3F8	507	535	521	541	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	536	557	521	541	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	507	535	521	541	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	536	557	521	541	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	647	703	630	650	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	647	703	630	650	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	647	703	678	698	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	647	703	678	698	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63B	Q5T3F8	507	535	492	832	Alternative sequence	ID=VSP_023890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM63B	Q5T3F8	536	557	492	832	Alternative sequence	ID=VSP_023890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM63B	Q5T3F8	647	703	492	832	Alternative sequence	ID=VSP_023890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM63B	Q5T3F8	507	535	492	832	Alternative sequence	ID=VSP_023890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM63B	Q5T3F8	536	557	492	832	Alternative sequence	ID=VSP_023890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TMEM63B	Q5T3F8	647	703	492	832	Alternative sequence	ID=VSP_023890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CSMD3	Q7Z407	3489	3542	1	3707	Chain	ID=PRO_0000021027;Note=CUB and sushi domain-containing protein 3
CSMD3	Q7Z407	447	473	1	3707	Chain	ID=PRO_0000021027;Note=CUB and sushi domain-containing protein 3
CSMD3	Q7Z407	343	447	1	3707	Chain	ID=PRO_0000021027;Note=CUB and sushi domain-containing protein 3
CSMD3	Q7Z407	3489	3542	64	3630	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	447	473	64	3630	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	343	447	64	3630	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	343	447	241	345	Domain	Note=CUB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
CSMD3	Q7Z407	343	447	361	361	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	343	447	409	409	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	3489	3542	3522	3522	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	3489	3542	3529	3529	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSMD3	Q7Z407	447	473	344	447	Alternative sequence	ID=VSP_009048;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12906867;Dbxref=PMID:12906867
CSMD3	Q7Z407	343	447	344	447	Alternative sequence	ID=VSP_009048;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12906867;Dbxref=PMID:12906867
CSMD3	Q7Z407	3489	3542	2676	3707	Alternative sequence	ID=VSP_009052;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COPS3	Q9UNS2	379	406	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	341	379	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	312	341	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	254	312	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	207	254	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	147	207	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	116	147	2	423	Chain	ID=PRO_0000120978;Note=COP9 signalosome complex subunit 3
COPS3	Q9UNS2	341	379	197	365	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS3	Q9UNS2	312	341	197	365	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS3	Q9UNS2	254	312	197	365	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS3	Q9UNS2	207	254	197	365	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS3	Q9UNS2	147	207	197	365	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS5	Q92905	126	169	2	334	Chain	ID=PRO_0000194835;Note=COP9 signalosome complex subunit 5
COPS5	Q92905	126	169	55	192	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	138	151	Motif	Note=JAMM motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	138	138	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	140	140	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	151	151	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	138	138	Mutagenesis	Note=Abolishes ability to deneddylate cullins%2C without affecting the 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19214193;Dbxref=PMID:19214193
COPS5	Q92905	126	169	129	129	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
COPS5	Q92905	126	169	111	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	132	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	141	143	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	149	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	166	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS4	Q9BT78	238	295	2	406	Chain	ID=PRO_0000120987;Note=COP9 signalosome complex subunit 4
COPS4	Q9BT78	238	295	197	366	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS4	Q9BT78	238	295	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0P
COPS4	Q9BT78	238	295	253	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0P
COPS4	Q9BT78	238	295	261	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0P
COPS4	Q9BT78	238	295	275	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0P
COPS4	Q9BT78	238	295	279	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0P
COPS4	Q9BT78	238	295	287	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D0P
CSPP1	Q1MSJ5	137	170	1	1256	Chain	ID=PRO_0000293464;Note=Centrosome and spindle pole-associated protein 1
CSPP1	Q1MSJ5	317	349	1	1256	Chain	ID=PRO_0000293464;Note=Centrosome and spindle pole-associated protein 1
CSPP1	Q1MSJ5	653	704	1	1256	Chain	ID=PRO_0000293464;Note=Centrosome and spindle pole-associated protein 1
CSPP1	Q1MSJ5	653	704	625	669	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CSPP1	Q1MSJ5	653	704	672	677	Compositional bias	Note=Poly-Gly
CSPP1	Q1MSJ5	137	170	1	329	Alternative sequence	ID=VSP_026475;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15580290;Dbxref=PMID:15580290
CSPP1	Q1MSJ5	317	349	1	329	Alternative sequence	ID=VSP_026475;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15580290;Dbxref=PMID:15580290
CSPP1	Q1MSJ5	137	170	138	172	Alternative sequence	ID=VSP_040072;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16826565;Dbxref=PMID:16826565
CSPP1	Q1MSJ5	653	704	689	740	Alternative sequence	ID=VSP_026476;Note=In isoform 2. TDLNRMHRQNIDAYHNPDARTYEDKRAVVSLDPNLATSNAENLEDAANKSSG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15580290;Dbxref=PMID:15580290
CSRNP1	Q96S65	155	260	1	589	Chain	ID=PRO_0000114786;Note=Cysteine/serine-rich nuclear protein 1
CSRNP1	Q96S65	155	260	1	589	Chain	ID=PRO_0000114786;Note=Cysteine/serine-rich nuclear protein 1
CSRNP1	Q96S65	155	260	237	275	Compositional bias	Note=Cys-rich
CSRNP1	Q96S65	155	260	237	275	Compositional bias	Note=Cys-rich
CSTF2	P33240	188	234	1	577	Chain	ID=PRO_0000081531;Note=Cleavage stimulation factor subunit 2
CSTF2	P33240	188	234	108	248	Region	Note=Interactions with CSTF3 and SYMPK
CSTF2	P33240	188	234	198	409	Compositional bias	Note=Gly/Pro-rich
CSTF2	P33240	188	234	189	189	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
C20orf194	Q5TEA3	1087	1109	1	1177	Chain	ID=PRO_0000236042;Note=Uncharacterized protein C20orf194
C20orf194	Q5TEA3	594	643	1	1177	Chain	ID=PRO_0000236042;Note=Uncharacterized protein C20orf194
C20orf194	Q5TEA3	230	263	1	1177	Chain	ID=PRO_0000236042;Note=Uncharacterized protein C20orf194
C20orf194	Q5TEA3	204	230	1	1177	Chain	ID=PRO_0000236042;Note=Uncharacterized protein C20orf194
CNOT11	Q9UKZ1	226	277	1	510	Chain	ID=PRO_0000089357;Note=CCR4-NOT transcription complex subunit 11
CNTN2	Q02246	658	708	31	1012	Chain	ID=PRO_0000014695;Note=Contactin-2
CNTN2	Q02246	658	708	610	708	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CNTNAP3	Q9BZ76	1147	1224	26	1288	Chain	ID=PRO_0000019509;Note=Contactin-associated protein-like 3
CNTNAP3	Q9BZ76	998	1073	26	1288	Chain	ID=PRO_0000019509;Note=Contactin-associated protein-like 3
CNTNAP3	Q9BZ76	918	998	26	1288	Chain	ID=PRO_0000019509;Note=Contactin-associated protein-like 3
CNTNAP3	Q9BZ76	845	918	26	1288	Chain	ID=PRO_0000019509;Note=Contactin-associated protein-like 3
CNTNAP3	Q9BZ76	179	247	26	1288	Chain	ID=PRO_0000019509;Note=Contactin-associated protein-like 3
CNTNAP3	Q9BZ76	1147	1224	26	1245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	998	1073	26	1245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	918	998	26	1245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	845	918	26	1245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	179	247	26	1245	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	179	247	183	364	Domain	Note=Laminin G-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CNTNAP3	Q9BZ76	918	998	793	958	Domain	Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CNTNAP3	Q9BZ76	845	918	793	958	Domain	Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CNTNAP3	Q9BZ76	918	998	962	996	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CNTNAP3	Q9BZ76	1147	1224	1015	1203	Domain	Note=Laminin G-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CNTNAP3	Q9BZ76	998	1073	1015	1203	Domain	Note=Laminin G-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CNTNAP3	Q9BZ76	998	1073	1023	1023	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	998	1073	1073	1073	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP3	Q9BZ76	918	998	931	958	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP3	Q9BZ76	918	998	962	975	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP3	Q9BZ76	918	998	969	984	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP3	Q9BZ76	918	998	986	996	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP3	Q9BZ76	1147	1224	1167	1203	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP3	Q9BZ76	1147	1224	1128	1288	Alternative sequence	ID=VSP_003536;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214970;Dbxref=PMID:11214970
CNTNAP3	Q9BZ76	845	918	845	845	Natural variant	ID=VAR_046711;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11214970;Dbxref=dbSNP:rs7852039,PMID:11214970
C2	P06681	85	147	21	752	Chain	ID=PRO_0000027610;Note=Complement C2
C2	P06681	85	147	21	243	Chain	ID=PRO_0000027611;Note=Complement C2b fragment
C2	P06681	85	147	22	86	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C2	P06681	85	147	87	146	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C2	P06681	85	147	112	112	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
C2	P06681	85	147	89	131	Disulfide bond	.
C2	P06681	85	147	117	144	Disulfide bond	.
C2	P06681	85	147	1	147	Alternative sequence	ID=VSP_043038;Note=In isoform 2. MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNG->MRALCIRETCSSELGFSRNWSRRK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C2	P06681	85	147	16	147	Alternative sequence	ID=VSP_046103;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C2	P06681	85	147	131	131	Natural variant	ID=VAR_008544;Note=In C2D. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9670930;Dbxref=dbSNP:rs760744400,PMID:9670930
C2	P06681	85	147	83	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	88	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	105	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	112	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	122	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	127	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	137	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C2	P06681	85	147	143	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ERB
C3	P01024	1543	1571	23	1663	Chain	ID=PRO_0000005907;Note=Complement C3
C3	P01024	1420	1450	23	1663	Chain	ID=PRO_0000005907;Note=Complement C3
C3	P01024	1323	1343	23	1663	Chain	ID=PRO_0000005907;Note=Complement C3
C3	P01024	1130	1163	23	1663	Chain	ID=PRO_0000005907;Note=Complement C3
C3	P01024	682	748	23	1663	Chain	ID=PRO_0000005907;Note=Complement C3
C3	P01024	493	562	23	1663	Chain	ID=PRO_0000005907;Note=Complement C3
C3	P01024	493	562	23	667	Chain	ID=PRO_0000005908;Note=Complement C3 beta chain
C3	P01024	1543	1571	672	1663	Chain	ID=PRO_0000005909;Note=Complement C3 alpha chain
C3	P01024	1420	1450	672	1663	Chain	ID=PRO_0000005909;Note=Complement C3 alpha chain
C3	P01024	1323	1343	672	1663	Chain	ID=PRO_0000005909;Note=Complement C3 alpha chain
C3	P01024	1130	1163	672	1663	Chain	ID=PRO_0000005909;Note=Complement C3 alpha chain
C3	P01024	682	748	672	1663	Chain	ID=PRO_0000005909;Note=Complement C3 alpha chain
C3	P01024	682	748	672	748	Chain	ID=PRO_0000005910;Note=C3a anaphylatoxin
C3	P01024	682	748	672	747	Chain	ID=PRO_0000419935;Note=Acylation stimulating protein
C3	P01024	1543	1571	749	1663	Chain	ID=PRO_0000005911;Note=Complement C3b alpha' chain
C3	P01024	1420	1450	749	1663	Chain	ID=PRO_0000005911;Note=Complement C3b alpha' chain
C3	P01024	1323	1343	749	1663	Chain	ID=PRO_0000005911;Note=Complement C3b alpha' chain
C3	P01024	1130	1163	749	1663	Chain	ID=PRO_0000005911;Note=Complement C3b alpha' chain
C3	P01024	1130	1163	955	1303	Chain	ID=PRO_0000005913;Note=Complement C3dg fragment
C3	P01024	1130	1163	1002	1303	Chain	ID=PRO_0000005915;Note=Complement C3d fragment
C3	P01024	1543	1571	1321	1663	Chain	ID=PRO_0000273948;Note=Complement C3c alpha' chain fragment 2
C3	P01024	1420	1450	1321	1663	Chain	ID=PRO_0000273948;Note=Complement C3c alpha' chain fragment 2
C3	P01024	1323	1343	1321	1663	Chain	ID=PRO_0000273948;Note=Complement C3c alpha' chain fragment 2
C3	P01024	682	748	693	728	Domain	Note=Anaphylatoxin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00022
C3	P01024	1543	1571	1518	1661	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
C3	P01024	1420	1450	1424	1456	Region	Note=Properdin-binding
C3	P01024	682	748	747	748	Site	Note=Cleavage%3B by carboxypeptidases
C3	P01024	682	748	748	749	Site	Note=Cleavage%3B by C3 convertase
C3	P01024	682	748	559	816	Disulfide bond	Note=Interchain (between beta and alpha chains)
C3	P01024	493	562	559	816	Disulfide bond	Note=Interchain (between beta and alpha chains)
C3	P01024	682	748	693	720	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8416818;Dbxref=PMID:8416818
C3	P01024	682	748	694	727	Disulfide bond	.
C3	P01024	682	748	707	728	Disulfide bond	.
C3	P01024	1420	1450	873	1513	Disulfide bond	.
C3	P01024	1323	1343	873	1513	Disulfide bond	.
C3	P01024	1130	1163	873	1513	Disulfide bond	.
C3	P01024	1130	1163	1101	1158	Disulfide bond	.
C3	P01024	1420	1450	1358	1489	Disulfide bond	.
C3	P01024	1420	1450	1389	1458	Disulfide bond	.
C3	P01024	1543	1571	1518	1590	Disulfide bond	.
C3	P01024	1543	1571	1537	1661	Disulfide bond	.
C3	P01024	493	562	549	549	Natural variant	ID=VAR_001985;Note=In C3D%3B impairs secretion%3B variant confirmed at protein level. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22028381,ECO:0000269|PubMed:7961791;Dbxref=dbSNP:rs1449441916,PMID:22028381,PMID:7961791
C3	P01024	682	748	735	735	Natural variant	ID=VAR_063215;Note=In AHUS5. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18796626;Dbxref=dbSNP:rs117793540,PMID:18796626
C3	P01024	1130	1163	1158	1158	Natural variant	ID=VAR_063218;Note=In AHUS5. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18796626;Dbxref=PMID:18796626
C3	P01024	1130	1163	1161	1161	Natural variant	ID=VAR_063219;Note=In AHUS5%3B leads to impaired binding to the regulator CD46/MCP and resistance to cleavage by factor I. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18796626;Dbxref=PMID:18796626
C3	P01024	1130	1163	1140	1140	Mutagenesis	Note=No effect on binding of C3d to CR2. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:20083651,PMID:20951140
C3	P01024	1130	1163	1153	1153	Mutagenesis	Note=Impaired binding of C3d to CR2. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:20083651,PMID:20951140
C3	P01024	1130	1163	1156	1156	Mutagenesis	Note=Impaired binding of C3d to CR2. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:20083651,PMID:20951140
C3	P01024	1130	1163	1159	1159	Mutagenesis	Note=Impaired binding of C3d to CR2. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:20083651,PMID:20951140
C3	P01024	1130	1163	1160	1160	Mutagenesis	Note=Minor effect on binding of C3d to CR2. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:20083651,PMID:20951140
C3	P01024	1130	1163	1163	1163	Mutagenesis	Note=No effect on binding of C3d to CR2. Impaired binding of C3d to CR2%3B when associated with 1108-R-R-1109. N->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11387479,ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:11387479,PMID:20083651,PMID:20951140
C3	P01024	1130	1163	1163	1163	Mutagenesis	Note=Impaired binding of C3d to CR2. N->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11387479,ECO:0000269|PubMed:20083651,ECO:0000269|PubMed:20951140;Dbxref=PMID:11387479,PMID:20083651,PMID:20951140
C3	P01024	682	748	700	700	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
C3	P01024	493	562	489	496	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	493	562	499	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	493	562	513	520	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	493	562	523	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	493	562	527	538	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	493	562	540	542	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QKI
C3	P01024	493	562	544	554	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	682	748	675	684	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HW5
C3	P01024	682	748	688	697	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I6O
C3	P01024	682	748	707	710	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I6O
C3	P01024	682	748	712	714	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HW5
C3	P01024	682	748	718	743	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I6O
C3	P01024	1130	1163	1127	1133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WY7
C3	P01024	1130	1163	1139	1158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WY7
C3	P01024	1130	1163	1159	1161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WY7
C3	P01024	1323	1343	1320	1326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO8
C3	P01024	1323	1343	1330	1338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO8
C3	P01024	1323	1343	1340	1350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO8
C3	P01024	1420	1450	1415	1422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	1420	1450	1424	1428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EHG
C3	P01024	1420	1450	1431	1434	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	1420	1450	1438	1440	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	1420	1450	1442	1449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	1543	1571	1541	1553	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
C3	P01024	1543	1571	1556	1570	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A74
COL5A1	P20908	262	308	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	711	729	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	810	828	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	828	864	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	900	915	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	933	948	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	1284	1302	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	1356	1374	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	1518	1536	38	1605	Chain	ID=PRO_0000005756;Note=Collagen alpha-1(V) chain
COL5A1	P20908	1689	1712	1606	1838	Propeptide	ID=PRO_0000005757;Note=C-terminal propeptide
COL5A1	P20908	1689	1712	1609	1837	Domain	Note=Fibrillar collagen NC1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00793
COL5A1	P20908	262	308	231	443	Region	Note=Nonhelical region
COL5A1	P20908	711	729	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	810	828	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	828	864	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	900	915	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	933	948	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	1284	1302	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	1356	1374	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	1518	1536	559	1570	Region	Note=Triple-helical region
COL5A1	P20908	262	308	262	262	Modified residue	Note=Sulfotyrosine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL5A1	P20908	262	308	263	263	Modified residue	Note=Sulfotyrosine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL5A1	P20908	711	729	717	717	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2496661;Dbxref=PMID:2496661
COL5A1	P20908	711	729	720	720	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2496661;Dbxref=PMID:2496661
COL5A1	P20908	711	729	726	726	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2496661;Dbxref=PMID:2496661
COL5A1	P20908	810	828	810	810	Modified residue	Note=5-hydroxylysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2496661;Dbxref=PMID:2496661
COL5A1	P20908	810	828	816	816	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2496661;Dbxref=PMID:2496661
COL5A1	P20908	810	828	819	819	Modified residue	Note=5-hydroxylysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2496661;Dbxref=PMID:2496661
COL5A1	P20908	828	864	834	834	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2496661,ECO:0000269|PubMed:8181482;Dbxref=PMID:2496661,PMID:8181482
COL5A1	P20908	828	864	846	846	Modified residue	Note=5-hydroxylysine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2496661,ECO:0000269|PubMed:8181482;Dbxref=PMID:2496661,PMID:8181482
COL5A1	P20908	828	864	861	861	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2496661,ECO:0000269|PubMed:8181482;Dbxref=PMID:2496661,PMID:8181482
COL5A1	P20908	828	864	864	864	Modified residue	Note=5-hydroxylysine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2496661,ECO:0000269|PubMed:8181482;Dbxref=PMID:2496661,PMID:8181482
COL5A1	P20908	900	915	903	903	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2496661,ECO:0000269|PubMed:8181482;Dbxref=PMID:2496661,PMID:8181482
COL5A1	P20908	900	915	906	906	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2496661,ECO:0000269|PubMed:8181482;Dbxref=PMID:2496661,PMID:8181482
COL5A1	P20908	933	948	945	945	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8181482;Dbxref=PMID:8181482
COL5A1	P20908	1689	1712	1680	1835	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00793
COL5A1	P20908	1689	1712	1690	1711	Alternative sequence	ID=VSP_059655;Note=In isoform 2. ARITSWPKENPGSWFSEFKRGK->SKMARWPKEQPSTWYSQYKRGS
COL5A1	P20908	828	864	863	863	Natural variant	ID=VAR_075702;Note=E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26477546;Dbxref=dbSNP:rs139788610,PMID:26477546
COL5A1	P20908	900	915	908	908	Natural variant	ID=VAR_064702;Note=Found in a renal cell carcinoma case%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=dbSNP:rs772211736,PMID:21248752
COL5A1	P20908	711	729	727	727	Sequence conflict	Note=G->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL5A1	P20908	828	864	849	855	Sequence conflict	Note=GGPNGDP->IGPPGPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL5A1	P20908	1284	1302	1295	1299	Sequence conflict	Note=LPGEG->PSGRS;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL16A1	Q07092	1340	1352	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1257	1275	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1209	1227	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1185	1209	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1164	1185	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1152	1164	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1134	1152	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1083	1101	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	1050	1065	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	942	953	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	890	906	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	846	861	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	779	793	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	720	761	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	589	601	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	540	552	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	479	494	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	466	479	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	371	386	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	336	357	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	130	219	22	1604	Chain	ID=PRO_0000005792;Note=Collagen alpha-1(XVI) chain
COL16A1	Q07092	130	219	50	231	Domain	Note=Laminin G-like
COL16A1	Q07092	371	386	375	423	Domain	Note=Collagen-like 1
COL16A1	Q07092	589	601	573	633	Domain	Note=Collagen-like 2
COL16A1	Q07092	720	761	667	721	Domain	Note=Collagen-like 3
COL16A1	Q07092	779	793	788	840	Domain	Note=Collagen-like 4
COL16A1	Q07092	890	906	888	938	Domain	Note=Collagen-like 5
COL16A1	Q07092	1050	1065	1018	1075	Domain	Note=Collagen-like 6
COL16A1	Q07092	371	386	232	374	Region	Note=Nonhelical region 10 (NC10)
COL16A1	Q07092	336	357	232	374	Region	Note=Nonhelical region 10 (NC10)
COL16A1	Q07092	479	494	375	506	Region	Note=Triple-helical region 9 (COL9) with 3 imperfections
COL16A1	Q07092	466	479	375	506	Region	Note=Triple-helical region 9 (COL9) with 3 imperfections
COL16A1	Q07092	371	386	375	506	Region	Note=Triple-helical region 9 (COL9) with 3 imperfections
COL16A1	Q07092	540	552	522	555	Region	Note=Triple-helical region 8 (COL8) with 1 imperfection
COL16A1	Q07092	589	601	573	631	Region	Note=Triple-helical region 7 (COL7) with 1 imperfection
COL16A1	Q07092	720	761	653	723	Region	Note=Triple-helical region 6 (COL6) with 1 imperfection
COL16A1	Q07092	720	761	724	738	Region	Note=Nonhelical region 6 (NC6)
COL16A1	Q07092	846	861	739	876	Region	Note=Triple-helical region 5 (COL5) with 3 imperfections
COL16A1	Q07092	779	793	739	876	Region	Note=Triple-helical region 5 (COL5) with 3 imperfections
COL16A1	Q07092	720	761	739	876	Region	Note=Triple-helical region 5 (COL5) with 3 imperfections
COL16A1	Q07092	890	906	888	939	Region	Note=Triple-helical region 4 (COL4) with 2 imperfections
COL16A1	Q07092	942	953	940	973	Region	Note=Nonhelical region 4 (NC4)
COL16A1	Q07092	1340	1352	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1257	1275	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1209	1227	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1185	1209	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1164	1185	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1152	1164	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1134	1152	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1083	1101	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	1050	1065	1012	1433	Region	Note=Triple-helical region 2 (COL2) with 2 imperfections
COL16A1	Q07092	540	552	540	542	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL16A1	Q07092	1209	1227	1227	1229	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL16A1	Q07092	1050	1065	1052	1052	Alternative sequence	ID=VSP_024259;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
COL16A1	Q07092	1152	1164	1161	1161	Alternative sequence	ID=VSP_024260;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
COL16A1	Q07092	720	761	745	745	Natural variant	ID=VAR_048779;Note=G->S;Dbxref=dbSNP:rs34770879
COL16A1	Q07092	846	861	848	849	Sequence conflict	Note=RD->VM;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL16A1	Q07092	846	861	848	849	Sequence conflict	Note=RD->VM;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL16A1	Q07092	1152	1164	1161	1161	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL16A1	Q07092	1164	1185	1164	1164	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL16A1	Q07092	1152	1164	1164	1164	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL16A1	Q07092	1164	1185	1166	1166	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
COG2	Q14746	78	100	1	738	Chain	ID=PRO_0000213495;Note=Conserved oligomeric Golgi complex subunit 2
COG2	Q14746	198	258	1	738	Chain	ID=PRO_0000213495;Note=Conserved oligomeric Golgi complex subunit 2
COG3	Q96JB2	573	603	2	828	Chain	ID=PRO_0000213500;Note=Conserved oligomeric Golgi complex subunit 3
COG3	Q96JB2	573	603	445	828	Alternative sequence	ID=VSP_013653;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COG7	P83436	667	715	1	770	Chain	ID=PRO_0000213518;Note=Conserved oligomeric Golgi complex subunit 7
COG7	P83436	601	629	1	770	Chain	ID=PRO_0000213518;Note=Conserved oligomeric Golgi complex subunit 7
COG7	P83436	470	491	1	770	Chain	ID=PRO_0000213518;Note=Conserved oligomeric Golgi complex subunit 7
COG7	P83436	431	469	1	770	Chain	ID=PRO_0000213518;Note=Conserved oligomeric Golgi complex subunit 7
COG7	P83436	229	270	1	770	Chain	ID=PRO_0000213518;Note=Conserved oligomeric Golgi complex subunit 7
COG7	P83436	106	145	1	770	Chain	ID=PRO_0000213518;Note=Conserved oligomeric Golgi complex subunit 7
COG7	P83436	601	629	605	605	Natural variant	ID=VAR_048762;Note=T->M;Dbxref=dbSNP:rs16940094
COL21A1	Q96P44	802	869	23	957	Chain	ID=PRO_0000317613;Note=Collagen alpha-1(XXI) chain
COL21A1	Q96P44	697	709	23	957	Chain	ID=PRO_0000317613;Note=Collagen alpha-1(XXI) chain
COL21A1	Q96P44	655	673	23	957	Chain	ID=PRO_0000317613;Note=Collagen alpha-1(XXI) chain
COL21A1	Q96P44	457	478	23	957	Chain	ID=PRO_0000317613;Note=Collagen alpha-1(XXI) chain
COL21A1	Q96P44	457	478	448	500	Domain	Note=Collagen-like 1
COL21A1	Q96P44	697	709	681	733	Domain	Note=Collagen-like 4
COL21A1	Q96P44	802	869	825	882	Domain	Note=Collagen-like 6
COL21A1	Q96P44	457	478	1	600	Alternative sequence	ID=VSP_031083;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
COL21A1	Q96P44	802	869	803	836	Alternative sequence	ID=VSP_031086;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
COL21A1	Q96P44	802	869	821	821	Natural variant	ID=VAR_038560;Note=L->P;Dbxref=dbSNP:rs12209452
COL21A1	Q96P44	802	869	827	827	Natural variant	ID=VAR_038561;Note=P->A;Dbxref=dbSNP:rs1555131
COL21A1	Q96P44	802	869	802	802	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
COIL	P38432	451	480	1	576	Chain	ID=PRO_0000058146;Note=Coilin
COIL	P38432	451	480	460	559	Domain	Note=Tudor%3B atypical
COIL	P38432	451	480	386	520	Region	Note=2 X 4 AA repeats of S-L-P-A
COIL	P38432	451	480	456	456	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
COL25A1	Q9BXS0	615	641	1	654	Chain	ID=PRO_0000259611;Note=Collagen alpha-1(XXV) chain
COL25A1	Q9BXS0	552	570	1	654	Chain	ID=PRO_0000259611;Note=Collagen alpha-1(XXV) chain
COL25A1	Q9BXS0	384	399	1	654	Chain	ID=PRO_0000259611;Note=Collagen alpha-1(XXV) chain
COL25A1	Q9BXS0	325	340	1	654	Chain	ID=PRO_0000259611;Note=Collagen alpha-1(XXV) chain
COL25A1	Q9BXS0	287	302	1	654	Chain	ID=PRO_0000259611;Note=Collagen alpha-1(XXV) chain
COL25A1	Q9BXS0	164	188	1	654	Chain	ID=PRO_0000259611;Note=Collagen alpha-1(XXV) chain
COL25A1	Q9BXS0	615	641	113	654	Chain	ID=PRO_0000259612;Note=Collagen-like Alzheimer amyloid plaque component;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927537,ECO:0000269|PubMed:15522881;Dbxref=PMID:11927537,PMID:15522881
COL25A1	Q9BXS0	552	570	113	654	Chain	ID=PRO_0000259612;Note=Collagen-like Alzheimer amyloid plaque component;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927537,ECO:0000269|PubMed:15522881;Dbxref=PMID:11927537,PMID:15522881
COL25A1	Q9BXS0	384	399	113	654	Chain	ID=PRO_0000259612;Note=Collagen-like Alzheimer amyloid plaque component;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927537,ECO:0000269|PubMed:15522881;Dbxref=PMID:11927537,PMID:15522881
COL25A1	Q9BXS0	325	340	113	654	Chain	ID=PRO_0000259612;Note=Collagen-like Alzheimer amyloid plaque component;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927537,ECO:0000269|PubMed:15522881;Dbxref=PMID:11927537,PMID:15522881
COL25A1	Q9BXS0	287	302	113	654	Chain	ID=PRO_0000259612;Note=Collagen-like Alzheimer amyloid plaque component;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927537,ECO:0000269|PubMed:15522881;Dbxref=PMID:11927537,PMID:15522881
COL25A1	Q9BXS0	164	188	113	654	Chain	ID=PRO_0000259612;Note=Collagen-like Alzheimer amyloid plaque component;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11927537,ECO:0000269|PubMed:15522881;Dbxref=PMID:11927537,PMID:15522881
COL25A1	Q9BXS0	615	641	55	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	552	570	55	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	384	399	55	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	325	340	55	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	287	302	55	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	164	188	55	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	164	188	121	164	Domain	Note=Collagen-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	287	302	249	308	Domain	Note=Collagen-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	325	340	311	370	Domain	Note=Collagen-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	384	399	372	425	Domain	Note=Collagen-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	615	641	571	630	Domain	Note=Collagen-like 7;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL25A1	Q9BXS0	164	188	181	188	Region	Note=Interaction with amyloid-beta peptide;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15522881;Dbxref=PMID:15522881
COL25A1	Q9BXS0	325	340	326	340	Alternative sequence	ID=VSP_052198;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14656069;Dbxref=PMID:14656069
COL25A1	Q9BXS0	615	641	589	640	Alternative sequence	ID=VSP_052199;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14656069;Dbxref=PMID:14656069
COL25A1	Q9BXS0	615	641	616	654	Alternative sequence	ID=VSP_052200;Note=In isoform 2. GFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK->VTSPSQHVPCLILLLLSALLFSLCDSI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11927537;Dbxref=PMID:11927537
COL25A1	Q9BXS0	164	188	181	188	Mutagenesis	Note=Reduces binding to amyloid-beta peptide. LIKRRLIK->VIKRRTFQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15522881;Dbxref=PMID:15522881
COL25A1	Q9BXS0	164	188	181	188	Mutagenesis	Note=Abolishes binding to amyloid-beta peptide. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15522881;Dbxref=PMID:15522881
COPE	O14579	245	268	2	308	Chain	ID=PRO_0000193851;Note=Coatomer subunit epsilon
COPE	O14579	193	245	2	308	Chain	ID=PRO_0000193851;Note=Coatomer subunit epsilon
COPE	O14579	97	147	2	308	Chain	ID=PRO_0000193851;Note=Coatomer subunit epsilon
COPE	O14579	97	147	99	99	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
COPE	O14579	97	147	97	97	Alternative sequence	ID=VSP_042770;Note=In isoform 2. R->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COPE	O14579	97	147	98	148	Alternative sequence	ID=VSP_042771;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COPE	O14579	245	268	194	245	Alternative sequence	ID=VSP_045070;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COPE	O14579	193	245	194	245	Alternative sequence	ID=VSP_045070;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COPE	O14579	97	147	117	117	Natural variant	ID=VAR_054033;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10469566,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs10330,PMID:10469566,PMID:14702039
COPG1	Q9Y678	30	57	1	874	Chain	ID=PRO_0000193858;Note=Coatomer subunit gamma-1
COPG1	Q9Y678	133	164	1	874	Chain	ID=PRO_0000193858;Note=Coatomer subunit gamma-1
COPG1	Q9Y678	376	408	1	874	Chain	ID=PRO_0000193858;Note=Coatomer subunit gamma-1
COPG1	Q9Y678	549	591	1	874	Chain	ID=PRO_0000193858;Note=Coatomer subunit gamma-1
COPG1	Q9Y678	591	614	1	874	Chain	ID=PRO_0000193858;Note=Coatomer subunit gamma-1
COPG1	Q9Y678	376	408	356	392	Repeat	Note=HEAT 4
COPG1	Q9Y678	591	614	609	874	Region	Note=Interaction with ZNF289/ARFGAP2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14690497;Dbxref=PMID:14690497
COPG1	Q9Y678	591	614	594	594	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
COPG1	Q9Y678	591	614	609	618	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R4X
COQ6	Q9Y2Z9	204	240	29	468	Chain	ID=PRO_0000207583;Note=Ubiquinone biosynthesis monooxygenase COQ6%2C mitochondrial
COQ6	Q9Y2Z9	261	297	29	468	Chain	ID=PRO_0000207583;Note=Ubiquinone biosynthesis monooxygenase COQ6%2C mitochondrial
COQ6	Q9Y2Z9	204	240	208	208	Natural variant	ID=VAR_075225;Note=Probable disease-associated mutation found in patients with Schwannomatosis%3B loss of function. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24763291;Dbxref=dbSNP:rs606231262,PMID:24763291
COQ6	Q9Y2Z9	261	297	261	261	Natural variant	ID=VAR_078122;Note=In COQ10D6%3B unknown pathological significance. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28044327;Dbxref=dbSNP:rs371260604,PMID:28044327
COQ6	Q9Y2Z9	261	297	287	287	Natural variant	ID=VAR_068217;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17851169,PMID:15489334
COQ3	Q9NZJ6	78	128	1	85	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03190
COQ3	Q9NZJ6	162	243	86	369	Chain	ID=PRO_0000035926;Note=Ubiquinone biosynthesis O-methyltransferase%2C mitochondrial
COQ3	Q9NZJ6	78	128	86	369	Chain	ID=PRO_0000035926;Note=Ubiquinone biosynthesis O-methyltransferase%2C mitochondrial
COQ3	Q9NZJ6	78	128	124	124	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03190
COQ3	Q9NZJ6	162	243	175	175	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03190
COQ3	Q9NZJ6	162	243	222	222	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03190
COQ3	Q9NZJ6	162	243	196	196	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BMS4
COQ3	Q9NZJ6	162	243	180	180	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CORO2B	Q9UQ03	5	72	1	480	Chain	ID=PRO_0000050930;Note=Coronin-2B
CORO2B	Q9UQ03	216	255	1	480	Chain	ID=PRO_0000050930;Note=Coronin-2B
CORO2B	Q9UQ03	5	72	29	77	Repeat	Note=WD 1
CORO2B	Q9UQ03	216	255	213	259	Repeat	Note=WD 5
CORO2B	Q9UQ03	5	72	1	6	Alternative sequence	ID=VSP_037706;Note=In isoform 2. MTVTKM->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CORO2B	Q9UQ03	216	255	238	238	Natural variant	ID=VAR_058323;Note=L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852400,PMID:15489334
HSD11B1	P28845	172	220	1	292	Chain	ID=PRO_0000054619;Note=Corticosteroid 11-beta-dehydrogenase isozyme 1
HSD11B1	P28845	172	220	1	292	Chain	ID=PRO_0000054619;Note=Corticosteroid 11-beta-dehydrogenase isozyme 1
HSD11B1	P28845	172	220	25	292	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD11B1	P28845	172	220	25	292	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD11B1	P28845	172	220	183	187	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15513927,ECO:0000269|PubMed:17919905,ECO:0000269|PubMed:18069989,ECO:0000269|PubMed:18485702,ECO:0000269|PubMed:18553955,ECO:0000269|PubMed:19217779;Dbxref=PMID:15513927,PMID:17919905,PMID:18069989,PMID:18485702,PMID:18553955,PMID:19217779
HSD11B1	P28845	172	220	183	187	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15513927,ECO:0000269|PubMed:17919905,ECO:0000269|PubMed:18069989,ECO:0000269|PubMed:18485702,ECO:0000269|PubMed:18553955,ECO:0000269|PubMed:19217779;Dbxref=PMID:15513927,PMID:17919905,PMID:18069989,PMID:18485702,PMID:18553955,PMID:19217779
HSD11B1	P28845	172	220	218	222	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15513927,ECO:0000269|PubMed:17919905,ECO:0000269|PubMed:18069989,ECO:0000269|PubMed:18485702,ECO:0000269|PubMed:18553955,ECO:0000269|PubMed:19217779;Dbxref=PMID:15513927,PMID:17919905,PMID:18069989,PMID:18485702,PMID:18553955,PMID:19217779
HSD11B1	P28845	172	220	218	222	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15513927,ECO:0000269|PubMed:17919905,ECO:0000269|PubMed:18069989,ECO:0000269|PubMed:18485702,ECO:0000269|PubMed:18553955,ECO:0000269|PubMed:19217779;Dbxref=PMID:15513927,PMID:17919905,PMID:18069989,PMID:18485702,PMID:18553955,PMID:19217779
HSD11B1	P28845	172	220	183	183	Active site	Note=Proton acceptor
HSD11B1	P28845	172	220	183	183	Active site	Note=Proton acceptor
HSD11B1	P28845	172	220	207	207	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD11B1	P28845	172	220	207	207	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
HSD11B1	P28845	172	220	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XU9
HSD11B1	P28845	172	220	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XU9
HSD11B1	P28845	172	220	181	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XU9
HSD11B1	P28845	172	220	181	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XU9
HSD11B1	P28845	172	220	209	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XU9
HSD11B1	P28845	172	220	209	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XU9
COX16	Q9P0S2	47	68	1	106	Chain	ID=PRO_0000019556;Note=Cytochrome c oxidase assembly protein COX16 homolog%2C mitochondrial
COX16	Q9P0S2	47	68	38	106	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:29355485,ECO:0000305|PubMed:29381136;Dbxref=PMID:29355485,PMID:29381136
CYP39A1	Q9NYL5	355	387	1	469	Chain	ID=PRO_0000051992;Note=24-hydroxycholesterol 7-alpha-hydroxylase
CYP39A1	Q9NYL5	244	280	1	469	Chain	ID=PRO_0000051992;Note=24-hydroxycholesterol 7-alpha-hydroxylase
CYP4F11	Q9HBI6	114	132	1	524	Chain	ID=PRO_0000051856;Note=Phylloquinone omega-hydroxylase CYP4F11
CYP4F11	Q9HBI6	114	132	1	524	Chain	ID=PRO_0000051856;Note=Phylloquinone omega-hydroxylase CYP4F11
CYP4B1	P13584	107	122	1	511	Chain	ID=PRO_0000051819;Note=Cytochrome P450 4B1
CYP4B1	P13584	107	122	111	111	Natural variant	ID=VAR_055377;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs45559437
CPSF4L	A6NMK7	102	134	1	179	Chain	ID=PRO_0000317366;Note=Putative cleavage and polyadenylation specificity factor subunit 4-like protein
CPSF4L	A6NMK7	102	134	90	117	Zinc finger	Note=C3H1-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CPSF4L	A6NMK7	102	134	118	145	Zinc finger	Note=C3H1-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
CAPNS1	P04632	81	111	1	268	Chain	ID=PRO_0000073713;Note=Calpain small subunit 1
CAPNS1	P04632	201	240	1	268	Chain	ID=PRO_0000073713;Note=Calpain small subunit 1
CAPNS1	P04632	81	111	1	268	Chain	ID=PRO_0000073713;Note=Calpain small subunit 1
CAPNS1	P04632	201	240	1	268	Chain	ID=PRO_0000073713;Note=Calpain small subunit 1
CAPNS1	P04632	81	111	91	125	Domain	Note=EF-hand 1%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	81	111	91	125	Domain	Note=EF-hand 1%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	201	240	169	204	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	201	240	169	204	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	201	240	205	233	Domain	Note=EF-hand 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	201	240	205	233	Domain	Note=EF-hand 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	201	240	234	268	Domain	Note=EF-hand 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	201	240	234	268	Domain	Note=EF-hand 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	81	111	108	119	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	81	111	108	119	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPNS1	P04632	81	111	78	83	Compositional bias	Note=Poly-Pro
CAPNS1	P04632	81	111	78	83	Compositional bias	Note=Poly-Pro
CAPNS1	P04632	81	111	109	109	Metal binding	Note=Calcium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64537
CAPNS1	P04632	81	111	109	109	Metal binding	Note=Calcium 1%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64537
CAPNS1	P04632	201	240	225	225	Metal binding	Note=Calcium 4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64537
CAPNS1	P04632	201	240	225	225	Metal binding	Note=Calcium 4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64537
CAPNS1	P04632	201	240	224	224	Natural variant	ID=VAR_021089;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878750
CAPNS1	P04632	201	240	224	224	Natural variant	ID=VAR_021089;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878750
CAPNS1	P04632	81	111	97	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	81	111	97	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	81	111	110	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	81	111	110	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	201	240	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	201	240	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	201	240	222	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	201	240	222	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	201	240	226	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
CAPNS1	P04632	201	240	226	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PHJ
RCSD1	Q6JBY9	36	66	1	416	Chain	ID=PRO_0000320262;Note=CapZ-interacting protein
RCSD1	Q6JBY9	66	90	1	416	Chain	ID=PRO_0000320262;Note=CapZ-interacting protein
RCSD1	Q6JBY9	90	158	1	416	Chain	ID=PRO_0000320262;Note=CapZ-interacting protein
RCSD1	Q6JBY9	66	90	68	68	Modified residue	Note=Phosphoserine%3B by MAPK8%3B in vitro;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15850461;Dbxref=PMID:23186163,PMID:15850461
RCSD1	Q6JBY9	66	90	82	82	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RCSD1	Q6JBY9	66	90	83	83	Modified residue	Note=Phosphoserine%3B by MAPK8%3B in vitro;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15850461;Dbxref=PMID:23186163,PMID:15850461
RCSD1	Q6JBY9	90	158	105	105	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
RCSD1	Q6JBY9	90	158	108	108	Modified residue	Note=Phosphoserine%3B by MAPK12 and MAPK13;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:15850461;Dbxref=PMID:19690332,PMID:23186163,PMID:15850461
RCSD1	Q6JBY9	90	158	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
RCSD1	Q6JBY9	90	158	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
RCSD1	Q6JBY9	90	158	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
RCSD1	Q6JBY9	90	158	124	124	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UZA1
RCSD1	Q6JBY9	90	158	126	126	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UZA1
RCSD1	Q6JBY9	90	158	127	127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RCSD1	Q6JBY9	90	158	135	135	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UZA1
RCSD1	Q6JBY9	90	158	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UZA1
RCSD1	Q6JBY9	36	66	1	310	Alternative sequence	ID=VSP_031648;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RCSD1	Q6JBY9	66	90	1	310	Alternative sequence	ID=VSP_031648;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RCSD1	Q6JBY9	90	158	1	310	Alternative sequence	ID=VSP_031648;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RCSD1	Q6JBY9	36	66	48	48	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
RCSD1	Q6JBY9	66	90	74	74	Sequence conflict	Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
RCSD1	Q6JBY9	90	158	96	96	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
C17orf53	Q8N3J3	408	436	1	647	Chain	ID=PRO_0000288092;Note=Uncharacterized protein C17orf53
C17orf53	Q8N3J3	436	483	1	647	Chain	ID=PRO_0000288092;Note=Uncharacterized protein C17orf53
C17orf53	Q8N3J3	549	591	1	647	Chain	ID=PRO_0000288092;Note=Uncharacterized protein C17orf53
C17orf53	Q8N3J3	408	436	138	647	Alternative sequence	ID=VSP_025652;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C17orf53	Q8N3J3	436	483	138	647	Alternative sequence	ID=VSP_025652;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C17orf53	Q8N3J3	549	591	138	647	Alternative sequence	ID=VSP_025652;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C17orf53	Q8N3J3	408	436	409	484	Alternative sequence	ID=VSP_025653;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C17orf53	Q8N3J3	436	483	409	484	Alternative sequence	ID=VSP_025653;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CR2	P20023	846	908	21	1033	Chain	ID=PRO_0000006010;Note=Complement receptor type 2
CR2	P20023	846	908	21	971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR2	P20023	846	908	849	909	Domain	Note=Sushi 14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR2	P20023	846	908	861	861	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR2	P20023	846	908	851	894	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR2	P20023	846	908	880	907	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR2	P20023	846	908	886	886	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CR2	P20023	846	908	890	890	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CR2	P20023	846	908	902	902	Sequence conflict	Note=Q->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CR2	P20023	846	908	906	906	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNAJB13	P59910	57	111	1	316	Chain	ID=PRO_0000071039;Note=DnaJ homolog subfamily B member 13
DNAJB13	P59910	57	111	4	68	Domain	Note=J;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00286
DNAJB13	P59910	57	111	1	175	Alternative sequence	ID=VSP_008519;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12673577;Dbxref=PMID:12673577
CREBL2	O60519	5	71	1	120	Chain	ID=PRO_0000318192;Note=cAMP-responsive element-binding protein-like 2
CREBL2	O60519	5	71	23	86	Domain	Note=bZIP
CREBL2	O60519	5	71	29	60	Region	Note=Basic motif;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREBL2	O60519	5	71	62	69	Region	Note=Leucine-zipper;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREG1	O75629	118	158	32	220	Chain	ID=PRO_0000006203;Note=Protein CREG1
CREG1	O75629	118	158	112	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XHN
CREG1	O75629	118	158	122	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XHN
CREG1	O75629	118	158	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XHN
CREG1	O75629	118	158	134	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XHN
CREG1	O75629	118	158	149	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XHN
CRELD1	Q96HD1	86	122	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	244	272	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	304	349	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	86	122	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	244	272	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	304	349	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	86	122	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	244	272	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	304	349	30	420	Chain	ID=PRO_0000042781;Note=Cysteine-rich with EGF-like domain protein 1
CRELD1	Q96HD1	86	122	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	244	272	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	304	349	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	86	122	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	244	272	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	304	349	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	86	122	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	244	272	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	304	349	30	362	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRELD1	Q96HD1	244	272	208	256	Repeat	Note=FU 1
CRELD1	Q96HD1	244	272	208	256	Repeat	Note=FU 1
CRELD1	Q96HD1	244	272	208	256	Repeat	Note=FU 1
CRELD1	Q96HD1	244	272	268	315	Repeat	Note=FU 2
CRELD1	Q96HD1	304	349	268	315	Repeat	Note=FU 2
CRELD1	Q96HD1	244	272	268	315	Repeat	Note=FU 2
CRELD1	Q96HD1	304	349	268	315	Repeat	Note=FU 2
CRELD1	Q96HD1	244	272	268	315	Repeat	Note=FU 2
CRELD1	Q96HD1	304	349	268	315	Repeat	Note=FU 2
CRELD1	Q96HD1	304	349	305	344	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	305	344	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	305	344	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	309	321	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	309	321	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	309	321	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	314	330	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	314	330	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	314	330	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	332	343	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	332	343	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	304	349	332	343	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRELD1	Q96HD1	86	122	107	107	Natural variant	ID=VAR_023764;Note=In AVSD2%3B associated with disease susceptibility. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28941780,PMID:12632326
CRELD1	Q96HD1	86	122	107	107	Natural variant	ID=VAR_023764;Note=In AVSD2%3B associated with disease susceptibility. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28941780,PMID:12632326
CRELD1	Q96HD1	86	122	107	107	Natural variant	ID=VAR_023764;Note=In AVSD2%3B associated with disease susceptibility. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28941780,PMID:12632326
CRELD1	Q96HD1	304	349	311	311	Natural variant	ID=VAR_023766;Note=In AVSD2%3B associated with disease susceptibility. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28942092,PMID:12632326
CRELD1	Q96HD1	304	349	311	311	Natural variant	ID=VAR_023766;Note=In AVSD2%3B associated with disease susceptibility. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28942092,PMID:12632326
CRELD1	Q96HD1	304	349	311	311	Natural variant	ID=VAR_023766;Note=In AVSD2%3B associated with disease susceptibility. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28942092,PMID:12632326
CRELD1	Q96HD1	304	349	329	329	Natural variant	ID=VAR_023767;Note=In AVSD2%3B associated with disease susceptibility. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28942091,PMID:12632326
CRELD1	Q96HD1	304	349	329	329	Natural variant	ID=VAR_023767;Note=In AVSD2%3B associated with disease susceptibility. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28942091,PMID:12632326
CRELD1	Q96HD1	304	349	329	329	Natural variant	ID=VAR_023767;Note=In AVSD2%3B associated with disease susceptibility. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12632326;Dbxref=dbSNP:rs28942091,PMID:12632326
CRELD1	Q96HD1	304	349	336	336	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRELD1	Q96HD1	304	349	336	336	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRELD1	Q96HD1	304	349	336	336	Sequence conflict	Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRELD1	Q96HD1	304	349	348	348	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRELD1	Q96HD1	304	349	348	348	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRELD1	Q96HD1	304	349	348	348	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNAJC11	Q9NVH1	366	417	2	559	Chain	ID=PRO_0000247157;Note=DnaJ homolog subfamily C member 11
DNAJC11	Q9NVH1	169	210	2	559	Chain	ID=PRO_0000247157;Note=DnaJ homolog subfamily C member 11
DNAJC11	Q9NVH1	366	417	417	457	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAJC11	Q9NVH1	169	210	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5U458
DNAJC11	Q9NVH1	366	417	367	418	Alternative sequence	ID=VSP_019932;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAJC17	Q9NVM6	200	227	1	304	Chain	ID=PRO_0000247118;Note=DnaJ homolog subfamily C member 17
DNAJC17	Q9NVM6	200	227	178	249	Domain	Note=RRM
DNAJC17	Q9NVM6	200	227	204	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9O
DNAJC17	Q9NVM6	200	227	224	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9O
CRISPLD2	Q9H0B8	236	284	23	497	Chain	ID=PRO_0000248149;Note=Cysteine-rich secretory protein LCCL domain-containing 2
CRISPLD2	Q9H0B8	236	284	284	379	Domain	Note=LCCL 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00123
CRISPLD2	Q9H0B8	236	284	121	497	Alternative sequence	ID=VSP_020179;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CRISPLD2	Q9H0B8	236	284	160	497	Alternative sequence	ID=VSP_020180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
CRTAM	O95727	64	115	18	393	Chain	ID=PRO_0000292602;Note=Cytotoxic and regulatory T-cell molecule
CRTAM	O95727	64	115	18	287	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRTAM	O95727	64	115	18	114	Domain	Note=Ig-like V-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRTAM	O95727	64	115	87	87	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRTAM	O95727	64	115	38	98	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|Ref.7
CRTAM	O95727	64	115	1	199	Alternative sequence	ID=VSP_052471;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CRTAM	O95727	64	115	78	78	Natural variant	ID=VAR_049869;Note=A->D;Dbxref=dbSNP:rs34397316
CRTAM	O95727	64	115	65	65	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRTAM	O95727	64	115	72	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H5S
CRTAM	O95727	64	115	80	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H5S
CRTAM	O95727	64	115	90	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H5S
CRTAM	O95727	64	115	94	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H5S
DLG2	Q15700	659	676	1	870	Chain	ID=PRO_0000094553;Note=Disks large homolog 2
DLG2	Q15700	342	393	1	870	Chain	ID=PRO_0000094553;Note=Disks large homolog 2
DLG2	Q15700	342	393	360	360	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63622
DLG2	Q15700	342	393	365	365	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91XM9
DLG2	Q15700	342	393	1	518	Alternative sequence	ID=VSP_045634;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DLG2	Q15700	342	393	341	392	Alternative sequence	ID=VSP_015515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DLG2	Q15700	659	676	627	659	Alternative sequence	ID=VSP_015516;Note=In isoform 3 and isoform 5. SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE->DIPGLGDDGYGTKTL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
CSDC2	Q9Y534	59	99	1	153	Chain	ID=PRO_0000100351;Note=Cold shock domain-containing protein C2
CSDC2	Q9Y534	59	99	68	135	Domain	Note=CSD
DLGAP2	Q9P1A6	640	654	1	1054	Chain	ID=PRO_0000174291;Note=Disks large-associated protein 2
CSNK2A1	P68400	324	353	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	207	241	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	170	207	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	142	170	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	122	142	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	105	122	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	188	217	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	71	105	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	34	71	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	6	34	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
CSNK2A1	P68400	324	353	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	207	241	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	170	207	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	142	170	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	122	142	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	105	122	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	188	217	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	71	105	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	34	71	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	34	71	45	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	34	71	36	41	Region	Note=Interaction with beta subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250
CSNK2A1	P68400	142	170	156	156	Active site	Note=Proton acceptor
CSNK2A1	P68400	34	71	68	68	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A1	P68400	324	353	344	344	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7592773;Dbxref=PMID:7592773
CSNK2A1	P68400	122	142	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CSNK2A1	P68400	105	122	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CSNK2A1	P68400	71	105	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CSNK2A1	P68400	34	71	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CSNK2A1	P68400	6	34	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CSNK2A1	P68400	34	71	47	47	Natural variant	ID=VAR_077045;Note=In OCNDS. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27048600;Dbxref=dbSNP:rs869312845,PMID:27048600
CSNK2A1	P68400	34	71	50	50	Natural variant	ID=VAR_077046;Note=In OCNDS. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27048600;Dbxref=dbSNP:rs869312849,PMID:27048600
CSNK2A1	P68400	170	207	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
CSNK2A1	P68400	170	207	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
CSNK2A1	P68400	188	217	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
CSNK2A1	P68400	122	142	128	128	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSNK2A1	P68400	324	353	351	351	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSNK2A1	P68400	6	34	10	12	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	6	34	13	18	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	6	34	21	24	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	6	34	26	28	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	34	71	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	34	71	39	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	34	71	49	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	34	71	59	61	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	34	71	64	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	71	105	72	74	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CU6
CSNK2A1	P68400	71	105	75	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	71	105	97	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	105	122	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	71	105	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	105	122	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	105	122	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CVG
CSNK2A1	P68400	122	142	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	105	122	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	122	142	125	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	142	170	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	122	142	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	142	170	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	142	170	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	142	170	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	170	207	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	142	170	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	170	207	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CVG
CSNK2A1	P68400	170	207	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	188	217	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	170	207	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	188	217	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	207	241	212	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	188	217	212	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	207	241	230	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	207	241	238	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	324	353	322	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	324	353	325	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WAR
CSNK2A1	P68400	324	353	333	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JWH
COPS2	P61201	82	124	1	443	Chain	ID=PRO_0000120968;Note=COP9 signalosome complex subunit 2
COPS2	P61201	82	124	1	275	Region	Note=Mediates interaction with NIF3L1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61203
COPS2	P61201	82	124	124	124	Alternative sequence	ID=VSP_011884;Note=In isoform 2. Q->QNSDFLCQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DYNLRB1	Q9NP97	26	82	2	96	Chain	ID=PRO_0000220955;Note=Dynein light chain roadblock-type 1
DYNLRB1	Q9NP97	26	82	28	47	Alternative sequence	ID=VSP_007236;Note=In isoform 2. IPIKSTMDNPTTTQYASLMH->GWEPLGHCGDRSRPPAQGCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DYNLRB1	Q9NP97	26	82	48	96	Alternative sequence	ID=VSP_007237;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DYNLRB1	Q9NP97	26	82	71	71	Natural variant	ID=VAR_049125;Note=I->F;Dbxref=dbSNP:rs10036
DYNLRB1	Q9NP97	26	82	25	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Z
DYNLRB1	Q9NP97	26	82	29	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ5
DYNLRB1	Q9NP97	26	82	36	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ5
DYNLRB1	Q9NP97	26	82	66	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ5
DYNLRB1	Q9NP97	26	82	77	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HZ5
DYNLRB2	Q8TF09	26	82	2	96	Chain	ID=PRO_0000220958;Note=Dynein light chain roadblock-type 2
VCAN	P13611	347	1334	21	3396	Chain	ID=PRO_0000017522;Note=Versican core protein
VCAN	P13611	1334	3088	21	3396	Chain	ID=PRO_0000017522;Note=Versican core protein
VCAN	P13611	3126	3164	21	3396	Chain	ID=PRO_0000017522;Note=Versican core protein
VCAN	P13611	3293	3354	21	3396	Chain	ID=PRO_0000017522;Note=Versican core protein
VCAN	P13611	347	1334	251	347	Domain	Note=Link 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00323
VCAN	P13611	3126	3164	3127	3163	Domain	Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VCAN	P13611	3293	3354	3294	3354	Domain	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
VCAN	P13611	347	1334	348	1335	Region	Note=GAG-alpha (glucosaminoglycan attachment domain)
VCAN	P13611	1334	3088	348	1335	Region	Note=GAG-alpha (glucosaminoglycan attachment domain)
VCAN	P13611	1334	3088	1336	3089	Region	Note=GAG-beta
VCAN	P13611	1334	3088	2116	2116	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:26091039;Dbxref=PMID:24275569,PMID:26091039
VCAN	P13611	1334	3088	2608	2608	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62059
VCAN	P13611	1334	3088	2617	2617	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
VCAN	P13611	347	1334	615	615	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	347	1334	782	782	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	347	1334	809	809	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	347	1334	1332	1332	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	1398	1398	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	1442	1442	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	1468	1468	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	1663	1663	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	1898	1898	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2179	2179	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2272	2272	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2280	2280	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2360	2360	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2385	2385	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2392	2392	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2496	2496	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2628	2628	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	2934	2934	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	1334	3088	3067	3067	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAN	P13611	3126	3164	3131	3142	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VCAN	P13611	3126	3164	3136	3151	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VCAN	P13611	3126	3164	3153	3162	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VCAN	P13611	3293	3354	3296	3339	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VCAN	P13611	3293	3354	3325	3352	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VCAN	P13611	347	1334	348	348	Alternative sequence	ID=VSP_003082;Note=In isoform V1 and isoform V3. P->R;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:2583089,ECO:0000303|PubMed:7876137,ECO:0000303|PubMed:7921538;Dbxref=PMID:2583089,PMID:7876137,PMID:7921538
VCAN	P13611	347	1334	349	3089	Alternative sequence	ID=VSP_003085;Note=In isoform V3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876137;Dbxref=PMID:7876137
VCAN	P13611	1334	3088	349	3089	Alternative sequence	ID=VSP_003085;Note=In isoform V3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876137;Dbxref=PMID:7876137
VCAN	P13611	347	1334	349	1335	Alternative sequence	ID=VSP_003083;Note=In isoform V1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:2583089,ECO:0000303|PubMed:7921538;Dbxref=PMID:2583089,PMID:7921538
VCAN	P13611	1334	3088	349	1335	Alternative sequence	ID=VSP_003083;Note=In isoform V1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:2583089,ECO:0000303|PubMed:7921538;Dbxref=PMID:2583089,PMID:7921538
VCAN	P13611	1334	3088	1336	3089	Alternative sequence	ID=VSP_003084;Note=In isoform V2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7806529;Dbxref=PMID:7806529
VCAN	P13611	347	1334	428	428	Natural variant	ID=VAR_020214;Note=G->D;Dbxref=dbSNP:rs2287926
VCAN	P13611	1334	3088	1516	1516	Natural variant	ID=VAR_021959;Note=K->R;Dbxref=dbSNP:rs309559
VCAN	P13611	1334	3088	1826	1826	Natural variant	ID=VAR_031632;Note=R->H;Dbxref=dbSNP:rs188703
VCAN	P13611	1334	3088	2301	2301	Natural variant	ID=VAR_020215;Note=F->Y;Dbxref=dbSNP:rs160278
VCAN	P13611	1334	3088	2315	2315	Natural variant	ID=VAR_020216;Note=V->L;Dbxref=dbSNP:rs3734094
VCAN	P13611	1334	3088	2937	2937	Natural variant	ID=VAR_021960;Note=D->Y;Dbxref=dbSNP:rs160277
VCAN	P13611	1334	3088	3011	3011	Natural variant	ID=VAR_031633;Note=N->K;Dbxref=dbSNP:rs16900532
VCAN	P13611	1334	3088	2709	2713	Sequence conflict	Note=IKAEA->EFREV;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLSTN1	O94985	506	525	29	981	Chain	ID=PRO_0000004021;Note=Calsyntenin-1
CLSTN1	O94985	328	411	29	981	Chain	ID=PRO_0000004021;Note=Calsyntenin-1
CLSTN1	O94985	71	81	29	981	Chain	ID=PRO_0000004021;Note=Calsyntenin-1
CLSTN1	O94985	506	525	29	825	Chain	ID=PRO_0000323597;Note=Soluble Alc-alpha
CLSTN1	O94985	328	411	29	825	Chain	ID=PRO_0000323597;Note=Soluble Alc-alpha
CLSTN1	O94985	71	81	29	825	Chain	ID=PRO_0000323597;Note=Soluble Alc-alpha
CLSTN1	O94985	506	525	29	859	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN1	O94985	328	411	29	859	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN1	O94985	71	81	29	859	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN1	O94985	71	81	38	164	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CLSTN1	O94985	328	411	346	346	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN1	O94985	328	411	366	366	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN1	O94985	506	525	515	515	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN1	O94985	71	81	72	81	Alternative sequence	ID=VSP_032035;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12972431,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:12972431,PMID:14702039,PMID:15489334
CLSTN1	O94985	328	411	332	332	Natural variant	ID=VAR_048582;Note=A->T;Dbxref=dbSNP:rs7550295
CLSTN1	O94985	506	525	524	524	Natural variant	ID=VAR_039553;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853244,PMID:15489334
DMP1	Q13316	45	61	17	513	Chain	ID=PRO_0000021110;Note=Dentin matrix acidic phosphoprotein 1
DMP1	Q13316	45	61	46	61	Alternative sequence	ID=VSP_004191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CTNNA1	P35221	156	196	2	906	Chain	ID=PRO_0000064261;Note=Catenin alpha-1
CTNNA1	P35221	196	286	2	906	Chain	ID=PRO_0000064261;Note=Catenin alpha-1
CTNNA1	P35221	432	463	2	906	Chain	ID=PRO_0000064261;Note=Catenin alpha-1
CTNNA1	P35221	633	670	2	906	Chain	ID=PRO_0000064261;Note=Catenin alpha-1
CTNNA1	P35221	766	811	2	906	Chain	ID=PRO_0000064261;Note=Catenin alpha-1
CTNNA1	P35221	156	196	2	228	Region	Note=Involved in homodimerization
CTNNA1	P35221	196	286	2	228	Region	Note=Involved in homodimerization
CTNNA1	P35221	196	286	264	264	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CTNNA1	P35221	196	286	268	268	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CTNNA1	P35221	633	670	634	634	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
CTNNA1	P35221	633	670	641	641	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16807684,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:25653389;Dbxref=PMID:16807684,PMID:17081983,PMID:18220336,PMID:18318008,PMID:18669648,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569,PMID:25653389
CTNNA1	P35221	633	670	645	645	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18318008;Dbxref=PMID:18318008
CTNNA1	P35221	633	670	652	652	Modified residue	Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692,ECO:0000269|PubMed:25653389;Dbxref=PMID:17487921,PMID:18669648,PMID:21406692,PMID:25653389
CTNNA1	P35221	633	670	655	655	Modified residue	Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653389;Dbxref=PMID:25653389
CTNNA1	P35221	633	670	658	658	Modified residue	Note=Phosphothreonine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653389;Dbxref=PMID:25653389
CTNNA1	P35221	766	811	797	797	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CTNNA1	P35221	156	196	1	370	Alternative sequence	ID=VSP_047810;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:21708131;Dbxref=PMID:15489334,PMID:21708131
CTNNA1	P35221	196	286	1	370	Alternative sequence	ID=VSP_047810;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:21708131;Dbxref=PMID:15489334,PMID:21708131
CTNNA1	P35221	766	811	811	811	Alternative sequence	ID=VSP_017494;Note=In isoform 2. G->GNCDTCGALQGLKGWPPPLCLATHW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7945318;Dbxref=PMID:7945318
CTNNA1	P35221	156	196	179	179	Natural variant	ID=VAR_022303;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs28363394
CTNNA1	P35221	196	286	219	219	Natural variant	ID=VAR_022304;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs28363406
CTNNA1	P35221	633	670	641	641	Mutagenesis	Note=Abolishes phosphorylation by CK2. No effect on phosphorylation by CK1. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653389;Dbxref=PMID:25653389
CTNNA1	P35221	633	670	641	641	Mutagenesis	Note=Enhances phosphorylation by CK1. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653389;Dbxref=PMID:25653389
CTNNA1	P35221	633	670	652	658	Mutagenesis	Note=Abolishes phosphorylation by CK1. No effect on phosphorylation by CK2. SRTSVQT->ARTAVQA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653389;Dbxref=PMID:25653389
CTNNA1	P35221	633	670	652	652	Mutagenesis	Note=Abolishes phosphorylation by CK1. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25653389;Dbxref=PMID:25653389
CTNNA1	P35221	156	196	175	175	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	156	196	175	175	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	196	286	216	216	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	196	286	216	216	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	432	463	460	460	Sequence conflict	Note=L->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	432	463	460	460	Sequence conflict	Note=L->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	633	670	653	653	Sequence conflict	Note=R->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	633	670	653	653	Sequence conflict	Note=R->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	766	811	789	789	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTNNA1	P35221	432	463	413	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H6G
CTNNA1	P35221	432	463	444	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H6G
CXCL14	O95715	69	106	35	111	Chain	ID=PRO_0000005115;Note=C-X-C motif chemokine 14
CXCL14	O95715	69	106	67	81	Motif	Note=D-box
CXCL14	O95715	69	106	39	84	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987528;Dbxref=PMID:16987528
CXCL14	O95715	69	106	68	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDL
CXCL14	O95715	69	106	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDL
CXCL14	O95715	69	106	77	80	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDL
CXCL14	O95715	69	106	81	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDL
CXCL14	O95715	69	106	90	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDL
CYBA	P13498	68	95	2	195	Chain	ID=PRO_0000144907;Note=Cytochrome b-245 light chain
CYBA	P13498	68	95	91	127	Intramembrane	.
CYBA	P13498	68	95	94	94	Metal binding	Note=Iron (heme axial ligand);Ontology_term=ECO:0000255;evidence=ECO:0000255
CYBA	P13498	68	95	72	72	Natural variant	ID=VAR_005122;Note=Y->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19388116,ECO:0000269|PubMed:2469497,ECO:0000269|PubMed:3368442;Dbxref=dbSNP:rs4673,PMID:19388116,PMID:2469497,PMID:3368442
CYBA	P13498	68	95	90	90	Natural variant	ID=VAR_005123;Note=In ARCGD. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1415254;Dbxref=dbSNP:rs104894513,PMID:1415254
CYBA	P13498	68	95	90	90	Natural variant	ID=VAR_060579;Note=In ARCGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910929;Dbxref=dbSNP:rs179363892,PMID:10910929
CYBA	P13498	68	95	94	94	Natural variant	ID=VAR_005124;Note=In ARCGD. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1415254;Dbxref=dbSNP:rs104894510,PMID:1415254
COMMD8	Q9NX08	125	177	1	183	Chain	ID=PRO_0000077401;Note=COMM domain-containing protein 8
COMMD8	Q9NX08	125	177	116	183	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD8	Q9NX08	125	177	127	127	Sequence conflict	Note=A->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
COMMD2	Q86X83	76	134	1	199	Chain	ID=PRO_0000077386;Note=COMM domain-containing protein 2
COMMD2	Q86X83	76	134	123	190	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD2	Q86X83	76	134	113	113	Natural variant	ID=VAR_028010;Note=I->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11042152,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15799966;Dbxref=dbSNP:rs9843784,PMID:11042152,PMID:15489334,PMID:15799966
COMMD10	Q9Y6G5	44	81	2	202	Chain	ID=PRO_0000077405;Note=COMM domain-containing protein 10
COMMD10	Q9Y6G5	133	170	2	202	Chain	ID=PRO_0000077405;Note=COMM domain-containing protein 10
COMMD10	Q9Y6G5	133	170	133	202	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD10	Q9Y6G5	133	170	155	155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
COMMD4	Q9H0A8	25	47	1	199	Chain	ID=PRO_0000077393;Note=COMM domain-containing protein 4
COMMD4	Q9H0A8	60	100	1	199	Chain	ID=PRO_0000077393;Note=COMM domain-containing protein 4
COMMD4	Q9H0A8	100	127	1	199	Chain	ID=PRO_0000077393;Note=COMM domain-containing protein 4
COMMD4	Q9H0A8	127	186	1	199	Chain	ID=PRO_0000077393;Note=COMM domain-containing protein 4
COMMD4	Q9H0A8	127	186	130	199	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD4	Q9H0A8	100	127	101	186	Alternative sequence	ID=VSP_055664;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COMMD4	Q9H0A8	127	186	101	186	Alternative sequence	ID=VSP_055664;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COMMD4	Q9H0A8	127	186	128	187	Alternative sequence	ID=VSP_011394;Note=In isoform 2. MNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAE->K;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ARCN1	P48444	1	89	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22223895;Dbxref=PMID:22223895
ARCN1	P48444	1	89	2	511	Chain	ID=PRO_0000193841;Note=Coatomer subunit delta
ARCN1	P48444	89	149	2	511	Chain	ID=PRO_0000193841;Note=Coatomer subunit delta
ARCN1	P48444	1	89	1	89	Alternative sequence	ID=VSP_045636;Note=In isoform 2. MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRV->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARCN1	P48444	89	149	1	89	Alternative sequence	ID=VSP_045636;Note=In isoform 2. MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRV->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CORO1A	P31146	66	107	2	461	Chain	ID=PRO_0000050920;Note=Coronin-1A
CORO1A	P31146	355	427	2	461	Chain	ID=PRO_0000050920;Note=Coronin-1A
CORO1A	P31146	66	107	2	461	Chain	ID=PRO_0000050920;Note=Coronin-1A
CORO1A	P31146	355	427	2	461	Chain	ID=PRO_0000050920;Note=Coronin-1A
CORO1A	P31146	66	107	73	110	Repeat	Note=WD 2
CORO1A	P31146	66	107	73	110	Repeat	Note=WD 2
CORO1A	P31146	355	427	424	460	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CORO1A	P31146	355	427	424	460	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CORO1A	P31146	355	427	412	412	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23100250;Dbxref=PMID:23100250
CORO1A	P31146	355	427	412	412	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23100250;Dbxref=PMID:23100250
CORO1A	P31146	355	427	422	422	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O89053
CORO1A	P31146	355	427	422	422	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O89053
CORO1A	P31146	355	427	415	415	Natural variant	ID=VAR_011956;Note=R->K;Dbxref=dbSNP:rs1804109
CORO1A	P31146	355	427	415	415	Natural variant	ID=VAR_011956;Note=R->K;Dbxref=dbSNP:rs1804109
CORO1B	Q9BR76	355	448	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	252	287	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	212	252	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	67	108	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	355	448	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	252	287	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	212	252	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	67	108	1	489	Chain	ID=PRO_0000050922;Note=Coronin-1B
CORO1B	Q9BR76	67	108	18	72	Repeat	Note=WD 1
CORO1B	Q9BR76	67	108	18	72	Repeat	Note=WD 1
CORO1B	Q9BR76	67	108	73	122	Repeat	Note=WD 2
CORO1B	Q9BR76	67	108	73	122	Repeat	Note=WD 2
CORO1B	Q9BR76	252	287	211	256	Repeat	Note=WD 5
CORO1B	Q9BR76	212	252	211	256	Repeat	Note=WD 5
CORO1B	Q9BR76	252	287	211	256	Repeat	Note=WD 5
CORO1B	Q9BR76	212	252	211	256	Repeat	Note=WD 5
CORO1B	Q9BR76	252	287	257	296	Repeat	Note=WD 6
CORO1B	Q9BR76	252	287	257	296	Repeat	Note=WD 6
CORO1B	Q9BR76	355	448	411	411	Natural variant	ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974
CORO1B	Q9BR76	355	448	411	411	Natural variant	ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974
DHX15	O43143	595	636	1	795	Chain	ID=PRO_0000055139;Note=Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
DHX15	O43143	360	416	1	795	Chain	ID=PRO_0000055139;Note=Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
DHX15	O43143	360	416	338	518	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX15	O43143	360	416	361	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	368	370	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	371	373	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	378	380	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	383	388	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	394	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	400	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	409	412	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	360	416	415	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	595	636	604	606	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	595	636	607	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
DHX15	O43143	595	636	623	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDR
COX4I1	P13073	24	80	23	169	Chain	ID=PRO_0000006084;Note=Cytochrome c oxidase subunit 4 isoform 1%2C mitochondrial
COX4I1	P13073	80	124	23	169	Chain	ID=PRO_0000006084;Note=Cytochrome c oxidase subunit 4 isoform 1%2C mitochondrial
COX4I1	P13073	24	80	23	169	Chain	ID=PRO_0000006084;Note=Cytochrome c oxidase subunit 4 isoform 1%2C mitochondrial
COX4I1	P13073	80	124	23	169	Chain	ID=PRO_0000006084;Note=Cytochrome c oxidase subunit 4 isoform 1%2C mitochondrial
COX4I1	P13073	24	80	23	169	Chain	ID=PRO_0000006084;Note=Cytochrome c oxidase subunit 4 isoform 1%2C mitochondrial
COX4I1	P13073	80	124	23	169	Chain	ID=PRO_0000006084;Note=Cytochrome c oxidase subunit 4 isoform 1%2C mitochondrial
COX4I1	P13073	24	80	29	29	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	29	29	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	29	29	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	29	29	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	29	29	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	29	29	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
COX4I1	P13073	24	80	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
COX4I1	P13073	24	80	53	53	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
COX4I1	P13073	24	80	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10888
COX4I1	P13073	24	80	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10888
COX4I1	P13073	24	80	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10888
COX4I1	P13073	24	80	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10888
COX4I1	P13073	24	80	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10888
COX4I1	P13073	24	80	58	58	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10888
COX4I1	P13073	24	80	60	60	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
COX4I1	P13073	24	80	60	60	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
COX4I1	P13073	24	80	60	60	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
COX4I1	P13073	24	80	60	60	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	60	60	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	60	60	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	67	67	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	67	67	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	67	67	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19783
COX4I1	P13073	24	80	38	38	Natural variant	ID=VAR_002170;Note=Y->F
COX4I1	P13073	24	80	38	38	Natural variant	ID=VAR_002170;Note=Y->F
COX4I1	P13073	24	80	38	38	Natural variant	ID=VAR_002170;Note=Y->F
DHX33	Q9H6R0	226	283	1	707	Chain	ID=PRO_0000055164;Note=ATP-dependent RNA helicase DHX33
DHX33	Q9H6R0	226	283	84	252	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX33	Q9H6R0	226	283	277	450	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX34	Q14147	339	424	1	1143	Chain	ID=PRO_0000055166;Note=Probable ATP-dependent RNA helicase DHX34
DHX34	Q14147	902	994	1	1143	Chain	ID=PRO_0000055166;Note=Probable ATP-dependent RNA helicase DHX34
DHX34	Q14147	339	424	368	536	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX36	Q9H2U1	735	764	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	644	677	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	406	452	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	201	214	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	644	677	477	647	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX36	Q9H2U1	201	214	106	386	Region	Note=RecA-like domain 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	406	452	387	628	Region	Note=RecA-like domain 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	644	677	629	698	Region	Note=WH domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	644	677	638	697	Region	Note=Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	735	764	737	765	Alternative sequence	ID=VSP_020007;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DHX36	Q9H2U1	406	452	416	416	Natural variant	ID=VAR_027141;Note=S->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12198572,ECO:0000269|PubMed:14731398,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs9438,PMID:12198572,PMID:14731398,PMID:15489334
COX7A2L	O14548	24	68	1	55	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
COX7A2L	O14548	24	68	1	55	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
COX7A2L	O14548	24	68	56	114	Chain	ID=PRO_0000006154;Note=Cytochrome c oxidase subunit 7A-related protein%2C mitochondrial
COX7A2L	O14548	24	68	56	114	Chain	ID=PRO_0000006154;Note=Cytochrome c oxidase subunit 7A-related protein%2C mitochondrial
DIS3L2	Q8IYB7	439	475	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	475	553	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	641	670	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	763	798	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	439	475	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	475	553	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	641	670	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	763	798	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	439	475	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	528	603	Alternative sequence	ID=VSP_030375;Note=In isoform 3. AVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPE->QNADKDGAAHLQASHSPSAEDAEAQPSTEERLPETRGICDRDPDTRLFFLQQQSRVLEAKPQNTIRVEEQTTQLQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	475	553	528	603	Alternative sequence	ID=VSP_030375;Note=In isoform 3. AVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPE->QNADKDGAAHLQASHSPSAEDAEAQPSTEERLPETRGICDRDPDTRLFFLQQQSRVLEAKPQNTIRVEEQTTQLQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	641	670	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	763	798	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	641	670	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	763	798	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	641	670	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	763	798	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	641	670	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	763	798	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	439	475	443	443	Natural variant	ID=VAR_079527;Note=In PRLMNS%3B unknown pathological significance. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28328139;Dbxref=PMID:28328139
DIS3L2	Q8IYB7	439	475	443	443	Natural variant	ID=VAR_079527;Note=In PRLMNS%3B unknown pathological significance. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28328139;Dbxref=PMID:28328139
DIS3L2	Q8IYB7	475	553	483	483	Natural variant	ID=VAR_067577;Note=Probable disease-associated mutation found in a patient with Wilms tumor%3B does not suppress anchorage-independent cell growth. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs186865544,PMID:22306653
DIS3L2	Q8IYB7	475	553	483	483	Natural variant	ID=VAR_067577;Note=Probable disease-associated mutation found in a patient with Wilms tumor%3B does not suppress anchorage-independent cell growth. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs186865544,PMID:22306653
DIS3L2	Q8IYB7	475	553	489	489	Natural variant	ID=VAR_067578;Note=In PRLMNS. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs387907116,PMID:22306653
DIS3L2	Q8IYB7	475	553	489	489	Natural variant	ID=VAR_067578;Note=In PRLMNS. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs387907116,PMID:22306653
C16orf74	Q96GX8	9	57	1	76	Chain	ID=PRO_0000264621;Note=Uncharacterized protein C16orf74
C16orf74	Q96GX8	9	57	44	44	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
C16orf74	Q96GX8	9	57	46	46	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CEP135	Q66GS9	233	276	1	1140	Chain	ID=PRO_0000089491;Note=Centrosomal protein of 135 kDa
CEP135	Q66GS9	348	370	1	1140	Chain	ID=PRO_0000089491;Note=Centrosomal protein of 135 kDa
CEP135	Q66GS9	233	276	195	420	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP135	Q66GS9	348	370	195	420	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP135	Q66GS9	233	276	234	249	Alternative sequence	ID=VSP_012743;Note=In isoform 2. IELREREIERLSVALD->VGFLFTCIVGIEIGML;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CEP135	Q66GS9	233	276	250	1140	Alternative sequence	ID=VSP_012744;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CEP135	Q66GS9	348	370	250	1140	Alternative sequence	ID=VSP_012744;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIP2B	Q9P265	33	57	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	57	100	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	100	142	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	142	213	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	402	439	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	1270	1327	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	1367	1392	1	1576	Chain	ID=PRO_0000318736;Note=Disco-interacting protein 2 homolog B
DIP2B	Q9P265	33	57	14	131	Domain	Note=DMAP-interaction
DIP2B	Q9P265	57	100	14	131	Domain	Note=DMAP-interaction
DIP2B	Q9P265	100	142	14	131	Domain	Note=DMAP-interaction
DIP2B	Q9P265	142	213	145	234	Compositional bias	Note=Ser-rich
DIP2B	Q9P265	33	57	50	50	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DIP2B	Q9P265	33	57	53	53	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
DIP2B	Q9P265	57	100	71	71	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DIP2B	Q9P265	57	100	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
DIP2B	Q9P265	100	142	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
DIP2B	Q9P265	100	142	140	140	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DIP2B	Q9P265	142	213	146	146	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DIP2B	Q9P265	142	213	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DIP2B	Q9P265	142	213	153	153	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UH60
DIP2B	Q9P265	142	213	178	178	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DIP2B	Q9P265	142	213	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DIP2B	Q9P265	142	213	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
CYP2R1	Q6VVX0	122	333	1	501	Chain	ID=PRO_0000051778;Note=Vitamin D 25-hydroxylase
CYP2R1	Q6VVX0	122	333	250	250	Binding site	Note=Substrate%3B via carbonyl oxygen
CYP2R1	Q6VVX0	122	333	242	242	Natural variant	ID=VAR_075532;Note=Reduces 25-hydroxylase activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25942481;Dbxref=PMID:25942481
CYP2R1	Q6VVX0	122	333	131	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	147	150	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	154	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	171	174	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	180	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	205	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	224	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	233	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	239	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	242	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	276	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	297	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CYP2R1	Q6VVX0	122	333	330	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CZH
CPED1	A4D0V7	434	469	35	1026	Chain	ID=PRO_0000317732;Note=Cadherin-like and PC-esterase domain-containing protein 1
CPED1	A4D0V7	844	877	35	1026	Chain	ID=PRO_0000317732;Note=Cadherin-like and PC-esterase domain-containing protein 1
CPED1	A4D0V7	907	956	35	1026	Chain	ID=PRO_0000317732;Note=Cadherin-like and PC-esterase domain-containing protein 1
CPED1	A4D0V7	844	877	784	1026	Alternative sequence	ID=VSP_031141;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
CPED1	A4D0V7	907	956	784	1026	Alternative sequence	ID=VSP_031141;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
CPED1	A4D0V7	907	956	949	949	Natural variant	ID=VAR_038667;Note=K->T;Dbxref=dbSNP:rs798911
CPNE4	Q96A23	434	513	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	227	260	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	169	197	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	144	169	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	434	513	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	227	260	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	169	197	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	144	169	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	434	513	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	227	260	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	169	197	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	144	169	1	557	Chain	ID=PRO_0000144841;Note=Copine-4
CPNE4	Q96A23	227	260	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	169	197	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	144	169	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	227	260	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	169	197	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	144	169	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	227	260	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	169	197	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	144	169	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE4	Q96A23	434	513	305	507	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPNE4	Q96A23	434	513	305	507	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPNE4	Q96A23	434	513	305	507	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPSF3	Q9UKF6	71	113	2	684	Chain	ID=PRO_0000074400;Note=Cleavage and polyadenylation specificity factor subunit 3
CPSF3	Q9UKF6	365	414	2	684	Chain	ID=PRO_0000074400;Note=Cleavage and polyadenylation specificity factor subunit 3
CPSF3	Q9UKF6	414	465	2	684	Chain	ID=PRO_0000074400;Note=Cleavage and polyadenylation specificity factor subunit 3
CPSF3	Q9UKF6	365	414	396	396	Active site	Note=Proton donor;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPSF3	Q9UKF6	71	113	71	71	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2I7T,ECO:0000244|PDB:2I7V,ECO:0000269|PubMed:17128255;Dbxref=PMID:17128255
CPSF3	Q9UKF6	71	113	73	73	Metal binding	Note=Zinc 1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2I7T,ECO:0000244|PDB:2I7V,ECO:0000269|PubMed:17128255;Dbxref=PMID:17128255
CPSF3	Q9UKF6	71	113	75	75	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2I7T,ECO:0000244|PDB:2I7V,ECO:0000269|PubMed:17128255;Dbxref=PMID:17128255
CPSF3	Q9UKF6	71	113	76	76	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2I7T,ECO:0000244|PDB:2I7V,ECO:0000269|PubMed:17128255;Dbxref=PMID:17128255
CPSF3	Q9UKF6	414	465	418	418	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2I7T,ECO:0000244|PDB:2I7V,ECO:0000269|PubMed:17128255;Dbxref=PMID:17128255
CPSF3	Q9UKF6	414	465	462	462	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17923699;Dbxref=PMID:17923699
CPSF3	Q9UKF6	414	465	465	465	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17923699;Dbxref=PMID:17923699
CPSF3	Q9UKF6	71	113	73	73	Mutagenesis	Note=Inhibits histone 3'-end processing. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18688255;Dbxref=PMID:18688255
CPSF3	Q9UKF6	71	113	75	76	Mutagenesis	Note=Loss of histone 3'-end processing. DH->KA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17128255;Dbxref=PMID:17128255
CPSF3	Q9UKF6	71	113	75	75	Mutagenesis	Note=Inhibits histone 3'-end processing. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18688255;Dbxref=PMID:18688255
CPSF3	Q9UKF6	71	113	76	76	Mutagenesis	Note=Inhibits histone 3'-end processing. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18688255;Dbxref=PMID:18688255
CPSF3	Q9UKF6	365	414	396	396	Mutagenesis	Note=Inhibits histone 3'-end processing. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18688255;Dbxref=PMID:18688255
CPSF3	Q9UKF6	414	465	462	462	Mutagenesis	Note=Reduced sumoylation%3B when associated with R-465 and R-545. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17923699;Dbxref=PMID:17923699
CPSF3	Q9UKF6	414	465	465	465	Mutagenesis	Note=Reduced sumoylation%3B when associated with R-462 and R-545. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17923699;Dbxref=PMID:17923699
CPSF3	Q9UKF6	71	113	74	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	71	113	80	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	71	113	91	96	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	71	113	97	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	365	414	363	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	365	414	372	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	365	414	381	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	365	414	386	390	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	365	414	399	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	365	414	412	419	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	414	465	412	419	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	414	465	421	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	414	465	444	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPSF3	Q9UKF6	414	465	454	458	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I7T
CPS1	P31327	207	237	39	1500	Chain	ID=PRO_0000029897;Note=Carbamoyl-phosphate synthase [ammonia]%2C mitochondrial
CPS1	P31327	797	856	39	1500	Chain	ID=PRO_0000029897;Note=Carbamoyl-phosphate synthase [ammonia]%2C mitochondrial
CPS1	P31327	1186	1222	39	1500	Chain	ID=PRO_0000029897;Note=Carbamoyl-phosphate synthase [ammonia]%2C mitochondrial
CPS1	P31327	1222	1252	39	1500	Chain	ID=PRO_0000029897;Note=Carbamoyl-phosphate synthase [ammonia]%2C mitochondrial
CPS1	P31327	1334	1367	39	1500	Chain	ID=PRO_0000029897;Note=Carbamoyl-phosphate synthase [ammonia]%2C mitochondrial
CPS1	P31327	207	237	219	404	Domain	Note=Glutamine amidotransferase type-1
CPS1	P31327	1186	1222	1093	1284	Domain	Note=ATP-grasp 2
CPS1	P31327	1222	1252	1093	1284	Domain	Note=ATP-grasp 2
CPS1	P31327	1334	1367	1355	1500	Domain	Note=MGS-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01202
CPS1	P31327	207	237	39	218	Region	Note=Anthranilate phosphoribosyltransferase homolog
CPS1	P31327	207	237	207	207	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	207	207	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	207	237	207	207	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	210	210	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	210	210	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	207	237	214	214	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	214	214	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	207	237	214	214	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	219	219	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	219	219	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	207	237	228	228	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	228	228	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	207	237	237	237	Modified residue	Note=N6-glutaryllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	797	856	811	811	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	797	856	811	811	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	797	856	831	831	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	797	856	831	831	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	797	856	835	835	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CPS1	P31327	797	856	841	841	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	797	856	841	841	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	797	856	856	856	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	797	856	856	856	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	1186	1222	1203	1203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CPS1	P31327	1186	1222	1222	1222	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	1222	1252	1222	1222	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	1222	1252	1224	1224	Modified residue	Note=N6-glutaryllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	1222	1252	1232	1232	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	1222	1252	1232	1232	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	1334	1367	1356	1356	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	1334	1367	1356	1356	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	1334	1367	1356	1356	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	1334	1367	1360	1360	Modified residue	Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24703693;Dbxref=PMID:24703693
CPS1	P31327	1334	1367	1360	1360	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C196
CPS1	P31327	207	237	1	451	Alternative sequence	ID=VSP_009332;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
CPS1	P31327	207	237	212	212	Natural variant	ID=VAR_063561;Note=In CPS1D. Y->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310273;Dbxref=PMID:17310273
CPS1	P31327	207	237	224	224	Natural variant	ID=VAR_066178;Note=In CPS1D. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=PMID:21120950
CPS1	P31327	207	237	233	233	Natural variant	ID=VAR_066179;Note=In CPS1D. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=dbSNP:rs767905306,PMID:21120950
CPS1	P31327	797	856	803	803	Natural variant	ID=VAR_066145;Note=In CPS1D. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=dbSNP:rs201716417,PMID:21120950
CPS1	P31327	797	856	803	803	Natural variant	ID=VAR_066146;Note=In CPS1D. R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21120950,ECO:0000269|PubMed:26440671;Dbxref=dbSNP:rs201716417,PMID:21120950,PMID:26440671
CPS1	P31327	797	856	803	803	Natural variant	ID=VAR_066147;Note=In CPS1D. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=dbSNP:rs201716417,PMID:21120950
CPS1	P31327	797	856	805	805	Natural variant	ID=VAR_066148;Note=In CPS1D. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16737834;Dbxref=PMID:16737834
CPS1	P31327	797	856	805	805	Natural variant	ID=VAR_066149;Note=In CPS1D. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=PMID:21120950
CPS1	P31327	797	856	810	810	Natural variant	ID=VAR_017563;Note=In CPS1D. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12955727;Dbxref=PMID:12955727
CPS1	P31327	797	856	814	814	Natural variant	ID=VAR_066150;Note=In CPS1D. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=dbSNP:rs772782772,PMID:21120950
CPS1	P31327	797	856	816	816	Natural variant	ID=VAR_066151;Note=In CPS1D. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=PMID:21120950
CPS1	P31327	797	856	843	843	Natural variant	ID=VAR_017564;Note=In CPS1D%3B associated in cis with E-875%3B causes 70%25 decrease of enzyme activity%3B significant decrease in protein yield. L->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12655559,ECO:0000269|PubMed:15164414,ECO:0000269|PubMed:24813853;Dbxref=PMID:12655559,PMID:15164414,PMID:24813853
CPS1	P31327	797	856	850	850	Natural variant	ID=VAR_063569;Note=In CPS1D%3B moderate decrease in protein yield and partial loss of enzyme activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17310273,ECO:0000269|PubMed:24813853;Dbxref=dbSNP:rs1015051007,PMID:17310273,PMID:24813853
CPS1	P31327	797	856	850	850	Natural variant	ID=VAR_030675;Note=In CPS1D%3B partial loss of enzyme activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15617192,ECO:0000269|PubMed:21120950,ECO:0000269|PubMed:24813853,ECO:0000269|PubMed:26440671;Dbxref=dbSNP:rs767694281,PMID:15617192,PMID:21120950,PMID:24813853,PMID:26440671
CPS1	P31327	1186	1222	1194	1194	Natural variant	ID=VAR_075410;Note=In CPS1D. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24813853;Dbxref=PMID:24813853
CPS1	P31327	1186	1222	1195	1195	Natural variant	ID=VAR_063573;Note=In CPS1D. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310273;Dbxref=PMID:17310273
CPS1	P31327	1186	1222	1203	1203	Natural variant	ID=VAR_066129;Note=In CPS1D. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=dbSNP:rs149518280,PMID:21120950
CPS1	P31327	1186	1222	1203	1203	Natural variant	ID=VAR_066166;Note=In CPS1D. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16737834;Dbxref=PMID:16737834
CPS1	P31327	1186	1222	1205	1205	Natural variant	ID=VAR_066167;Note=In CPS1D. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16737834;Dbxref=PMID:16737834
CPS1	P31327	1186	1222	1215	1215	Natural variant	ID=VAR_063574;Note=In CPS1D. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310273;Dbxref=dbSNP:rs141373204,PMID:17310273
CPS1	P31327	1222	1252	1228	1228	Natural variant	ID=VAR_066130;Note=In CPS1D. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21120950;Dbxref=dbSNP:rs778117194,PMID:21120950
CPS1	P31327	1222	1252	1241	1241	Natural variant	ID=VAR_063575;Note=In CPS1D. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310273;Dbxref=PMID:17310273
CPS1	P31327	1334	1367	1363	1366	Natural variant	ID=VAR_075412;Note=In CPS1D%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26440671;Dbxref=PMID:26440671
CPS1	P31327	1186	1222	1204	1205	Sequence conflict	Note=GD->EN;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPS1	P31327	207	237	210	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	207	237	217	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	207	237	229	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	797	856	796	804	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	797	856	805	816	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	797	856	828	830	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	797	856	839	844	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	797	856	850	859	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1186	1222	1186	1197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1186	1222	1203	1205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOU
CPS1	P31327	1186	1222	1208	1211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1186	1222	1217	1233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1222	1252	1217	1233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1222	1252	1238	1247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1222	1252	1250	1259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1334	1367	1335	1341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DOT
CPS1	P31327	1334	1367	1344	1350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YVQ
CPS1	P31327	1334	1367	1360	1365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YVQ
CPT1B	Q92523	153	187	1	772	Chain	ID=PRO_0000210162;Note=Carnitine O-palmitoyltransferase 1%2C muscle isoform
CPT1B	Q92523	153	187	1	772	Chain	ID=PRO_0000210162;Note=Carnitine O-palmitoyltransferase 1%2C muscle isoform
CPT1B	Q92523	153	187	1	772	Chain	ID=PRO_0000210162;Note=Carnitine O-palmitoyltransferase 1%2C muscle isoform
CPT1B	Q92523	153	187	1	772	Chain	ID=PRO_0000210162;Note=Carnitine O-palmitoyltransferase 1%2C muscle isoform
CPT1B	Q92523	153	187	123	772	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1B	Q92523	153	187	123	772	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1B	Q92523	153	187	123	772	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1B	Q92523	153	187	123	772	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPT1B	Q92523	153	187	154	187	Alternative sequence	ID=VSP_043184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPT1B	Q92523	153	187	154	187	Alternative sequence	ID=VSP_043184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPT1B	Q92523	153	187	154	187	Alternative sequence	ID=VSP_043184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPT1B	Q92523	153	187	154	187	Alternative sequence	ID=VSP_043184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPT2	P23786	113	548	26	658	Chain	ID=PRO_0000004424;Note=Carnitine O-palmitoyltransferase 2%2C mitochondrial
CPT2	P23786	113	548	26	178	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	179	208	Intramembrane	Note=Note%3DMitochondrial inner membrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	209	658	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	452	464	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	372	372	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	486	486	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	488	488	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	499	499	Binding site	Note=Carnitine;Ontology_term=ECO:0000250;evidence=ECO:0000250
CPT2	P23786	113	548	239	239	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	239	239	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	305	305	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	424	424	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	439	439	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	510	510	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	510	510	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	544	544	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	544	544	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52825
CPT2	P23786	113	548	113	113	Natural variant	ID=VAR_001392;Note=In CPT2D%3B muscular form%3B frequent mutation. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15622536,ECO:0000269|PubMed:8358442,ECO:0000269|PubMed:9758712;Dbxref=dbSNP:rs74315294,PMID:15489334,PMID:15622536,PMID:8358442,PMID:9758712
CPT2	P23786	113	548	151	151	Natural variant	ID=VAR_020540;Note=In CPT2D. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14605500,ECO:0000269|PubMed:9758712;Dbxref=dbSNP:rs515726177,PMID:14605500,PMID:9758712
CPT2	P23786	113	548	174	174	Natural variant	ID=VAR_001393;Note=In CPT2D%3B muscular type. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600456;Dbxref=dbSNP:rs28936674,PMID:9600456
CPT2	P23786	113	548	210	210	Natural variant	ID=VAR_020541;Note=In CPT2D. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14605500;Dbxref=PMID:14605500
CPT2	P23786	113	548	213	213	Natural variant	ID=VAR_037976;Note=In CPT2D. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15622536;Dbxref=dbSNP:rs74315300,PMID:15622536
CPT2	P23786	113	548	214	214	Natural variant	ID=VAR_007966;Note=In CPT2D. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17;Dbxref=dbSNP:rs515726174
CPT2	P23786	113	548	227	227	Natural variant	ID=VAR_007967;Note=In CPT2D. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9758712,ECO:0000269|Ref.13;Dbxref=dbSNP:rs74315298,PMID:9758712
CPT2	P23786	113	548	296	296	Natural variant	ID=VAR_020542;Note=In CPT2D. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14605500,ECO:0000269|PubMed:14615409;Dbxref=dbSNP:rs764849762,PMID:14605500,PMID:14615409
CPT2	P23786	113	548	352	352	Natural variant	ID=VAR_001394;Note=Polymorphism associated with susceptibility to IIAE4%3B 3-fold decrease of affinity for L-carnitine%3B lower thermal stability compared to wild-type. F->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15811315,ECO:0000269|PubMed:18306170,ECO:0000269|PubMed:21697855,ECO:0000269|PubMed:9600456;Dbxref=dbSNP:rs2229291,PMID:15811315,PMID:18306170,PMID:21697855,PMID:9600456
CPT2	P23786	113	548	368	368	Natural variant	ID=VAR_001395;Note=Common polymorphism associated with susceptibility to IIAE4%3B no effect on activity%3B does not affect affinity for L-carnitine%3B lower thermal stability compared to wild-type. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14605500,ECO:0000269|PubMed:1528846,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:18306170,ECO:0000269|PubMed:9600456,ECO:0000269|PubMed:9758712;Dbxref=dbSNP:rs1799821,PMID:14605500,PMID:1528846,PMID:15489334,PMID:18306170,PMID:9600456,PMID:9758712
CPT2	P23786	113	548	383	383	Natural variant	ID=VAR_001396;Note=In CPT2D%3B hepatocardiomuscular form. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9600456;Dbxref=dbSNP:rs74315295,PMID:9600456
CPT2	P23786	113	548	448	448	Natural variant	ID=VAR_007968;Note=In CPT2D. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17;Dbxref=dbSNP:rs74315297
CPT2	P23786	113	548	479	479	Natural variant	ID=VAR_007969;Note=In CPT2D. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17;Dbxref=dbSNP:rs749895856
CPT2	P23786	113	548	503	503	Natural variant	ID=VAR_007970;Note=In CPT2D. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10090476;Dbxref=dbSNP:rs74315296,PMID:10090476
CPT2	P23786	113	548	504	504	Natural variant	ID=VAR_066567;Note=In a patient with IIAE4. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18306170;Dbxref=dbSNP:rs368311455,PMID:18306170
CRBN	Q96SW2	339	382	1	442	Chain	ID=PRO_0000076160;Note=Protein cereblon
CRBN	Q96SW2	339	382	318	426	Domain	Note=CULT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01124
CRBN	Q96SW2	339	382	378	386	Region	Note=Thalidomide binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4TZ4,ECO:0000269|PubMed:25108355;Dbxref=PMID:25108355
CRBN	Q96SW2	339	382	340	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V3O
CRBN	Q96SW2	339	382	344	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD
CRBN	Q96SW2	339	382	356	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD
CRBN	Q96SW2	339	382	367	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD
CROCC	Q5TZA2	117	179	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	179	207	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	319	397	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	430	458	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	1288	1344	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	1692	1767	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	1767	1817	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	1928	1989	1	2017	Chain	ID=PRO_0000239943;Note=Rootletin
CROCC	Q5TZA2	117	179	70	262	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	179	207	70	262	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	319	397	318	444	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	430	458	318	444	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	1288	1344	1091	1438	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	1692	1767	1505	1704	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	1928	1989	1921	1999	Compositional bias	Note=Gln-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
CROCC	Q5TZA2	117	179	1	697	Alternative sequence	ID=VSP_052069;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|Ref.1;Dbxref=PMID:12800201
CROCC	Q5TZA2	179	207	1	697	Alternative sequence	ID=VSP_052069;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|Ref.1;Dbxref=PMID:12800201
CROCC	Q5TZA2	319	397	1	697	Alternative sequence	ID=VSP_052069;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|Ref.1;Dbxref=PMID:12800201
CROCC	Q5TZA2	430	458	1	697	Alternative sequence	ID=VSP_052069;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|Ref.1;Dbxref=PMID:12800201
CROCC	Q5TZA2	1928	1989	1984	1990	Alternative sequence	ID=VSP_052070;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12800201,ECO:0000303|Ref.1;Dbxref=PMID:12800201
CROCC	Q5TZA2	319	397	372	372	Natural variant	ID=VAR_061627;Note=R->Q;Dbxref=dbSNP:rs57442576
CROCC	Q5TZA2	430	458	439	439	Natural variant	ID=VAR_059628;Note=A->V;Dbxref=dbSNP:rs4463721
CRB2	Q5IJ48	313	351	29	1285	Chain	ID=PRO_0000007502;Note=Protein crumbs homolog 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
CRB2	Q5IJ48	313	351	261	318	Domain	Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRB2	Q5IJ48	313	351	320	356	Domain	Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRB2	Q5IJ48	313	351	308	317	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRB2	Q5IJ48	313	351	324	335	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRB2	Q5IJ48	313	351	329	344	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRB2	Q5IJ48	313	351	346	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CRB2	Q5IJ48	313	351	1	332	Alternative sequence	ID=VSP_014737;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CRB2	Q5IJ48	313	351	333	351	Alternative sequence	ID=VSP_014738;Note=In isoform 3. GHCQDLPNGFQCHCPDGYA->MAMEPGALWTFLGHLWLLA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CRB2	Q5IJ48	313	351	351	351	Natural variant	ID=VAR_022990;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15851977;Dbxref=dbSNP:rs199679542,PMID:15851977
CRYL1	Q9Y2S2	146	211	2	319	Chain	ID=PRO_0000109320;Note=Lambda-crystallin homolog
CRYL1	Q9Y2S2	92	146	2	319	Chain	ID=PRO_0000109320;Note=Lambda-crystallin homolog
CRYL1	Q9Y2S2	92	146	97	97	Binding site	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.11
CRYL1	Q9Y2S2	92	146	102	102	Binding site	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.11
CRYL1	Q9Y2S2	92	146	111	111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CRYL1	Q9Y2S2	92	146	89	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	92	146	99	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	92	146	118	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	92	146	128	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	92	146	132	134	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	92	146	138	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	141	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	92	146	141	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	150	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	155	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	166	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	182	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	191	194	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
CRYL1	Q9Y2S2	146	211	195	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3F3S
DLG4	P78352	10	32	1	724	Chain	ID=PRO_0000094560;Note=Disks large homolog 4
DLG4	P78352	10	32	1	10	Alternative sequence	ID=VSP_014929;Note=In isoform 2. MDCLCIVTTK->MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9286702;Dbxref=PMID:9286702
DLG4	P78352	10	32	2	15	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MES
CSF1	P09603	13	54	1	32	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3498652;Dbxref=PMID:3498652
CSF1	P09603	13	54	1	32	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3498652;Dbxref=PMID:3498652
CSF1	P09603	13	54	33	554	Chain	ID=PRO_0000005857;Note=Macrophage colony-stimulating factor 1
CSF1	P09603	54	75	33	554	Chain	ID=PRO_0000005857;Note=Macrophage colony-stimulating factor 1
CSF1	P09603	13	54	33	554	Chain	ID=PRO_0000005857;Note=Macrophage colony-stimulating factor 1
CSF1	P09603	54	75	33	554	Chain	ID=PRO_0000005857;Note=Macrophage colony-stimulating factor 1
CSF1	P09603	13	54	33	450	Chain	ID=PRO_0000296231;Note=Processed macrophage colony-stimulating factor 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZQ0
CSF1	P09603	54	75	33	450	Chain	ID=PRO_0000296231;Note=Processed macrophage colony-stimulating factor 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZQ0
CSF1	P09603	13	54	33	450	Chain	ID=PRO_0000296231;Note=Processed macrophage colony-stimulating factor 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZQ0
CSF1	P09603	54	75	33	450	Chain	ID=PRO_0000296231;Note=Processed macrophage colony-stimulating factor 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZQ0
CSF1	P09603	13	54	33	496	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF1	P09603	54	75	33	496	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF1	P09603	13	54	33	496	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF1	P09603	54	75	33	496	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF1	P09603	13	54	39	122	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8422357;Dbxref=PMID:8422357
CSF1	P09603	54	75	39	122	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8422357;Dbxref=PMID:8422357
CSF1	P09603	13	54	39	122	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8422357;Dbxref=PMID:8422357
CSF1	P09603	54	75	39	122	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8422357;Dbxref=PMID:8422357
CSF1	P09603	54	75	63	63	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8422357;Dbxref=PMID:8422357
CSF1	P09603	54	75	63	63	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8422357;Dbxref=PMID:8422357
CSF1	P09603	54	75	69	69	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSF1	P09603	54	75	69	69	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSF1	P09603	13	54	37	41	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	13	54	37	41	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	13	54	45	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	54	75	45	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	13	54	45	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	54	75	45	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	54	75	65	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	54	75	65	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	54	75	72	74	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF1	P09603	54	75	72	74	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LXF
CSF3	P09919	68	104	30	207	Chain	ID=PRO_0000015570;Note=Granulocyte colony-stimulating factor
CSF3	P09919	68	104	69	75	Disulfide bond	.
CSF3	P09919	68	104	97	107	Disulfide bond	.
CSF3	P09919	68	104	66	68	Alternative sequence	ID=VSP_002673;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:2420009,ECO:0000303|PubMed:2423327,ECO:0000303|PubMed:3494801;Dbxref=PMID:2420009,PMID:2423327,PMID:3494801
CSF3	P09919	68	104	69	104	Alternative sequence	ID=VSP_045246;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15028279;Dbxref=PMID:15028279
CSF3	P09919	68	104	69	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW9
CSF3	P09919	68	104	77	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW9
CSF3	P09919	68	104	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW9
CSF3	P09919	68	104	104	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW9
CORO1C	Q9ULV4	250	285	1	474	Chain	ID=PRO_0000050926;Note=Coronin-1C
CORO1C	Q9ULV4	210	250	1	474	Chain	ID=PRO_0000050926;Note=Coronin-1C
CORO1C	Q9ULV4	65	106	1	474	Chain	ID=PRO_0000050926;Note=Coronin-1C
CORO1C	Q9ULV4	250	285	1	474	Chain	ID=PRO_0000050926;Note=Coronin-1C
CORO1C	Q9ULV4	210	250	1	474	Chain	ID=PRO_0000050926;Note=Coronin-1C
CORO1C	Q9ULV4	65	106	1	474	Chain	ID=PRO_0000050926;Note=Coronin-1C
CORO1C	Q9ULV4	65	106	25	70	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00221
CORO1C	Q9ULV4	65	106	25	70	Repeat	Note=WD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00221
CORO1C	Q9ULV4	65	106	78	118	Repeat	Note=WD 2;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:12377779;Dbxref=PMID:12377779
CORO1C	Q9ULV4	65	106	78	118	Repeat	Note=WD 2;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:12377779;Dbxref=PMID:12377779
CORO1C	Q9ULV4	210	250	215	249	Repeat	Note=WD 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:12377779;Dbxref=PMID:12377779
CORO1C	Q9ULV4	210	250	215	249	Repeat	Note=WD 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:12377779;Dbxref=PMID:12377779
CORO1C	Q9ULV4	250	285	263	303	Repeat	Note=WD 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:12377779;Dbxref=PMID:12377779
CORO1C	Q9ULV4	250	285	263	303	Repeat	Note=WD 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00221,ECO:0000269|PubMed:12377779;Dbxref=PMID:12377779
C16orf70	Q9BSU1	49	77	1	422	Chain	ID=PRO_0000221083;Note=UPF0183 protein C16orf70
C16orf70	Q9BSU1	49	77	1	422	Chain	ID=PRO_0000221083;Note=UPF0183 protein C16orf70
C16orf71	Q8IYS4	43	92	1	520	Chain	ID=PRO_0000294345;Note=Uncharacterized protein C16orf71
C16orf71	Q8IYS4	43	92	88	88	Natural variant	ID=VAR_033157;Note=E->D;Dbxref=dbSNP:rs17137215
CYP11A1	P05108	90	141	40	521	Chain	ID=PRO_0000003585;Note=Cholesterol side-chain cleavage enzyme%2C mitochondrial
CYP11A1	P05108	90	141	1	158	Alternative sequence	ID=VSP_045695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CYP11A1	P05108	90	141	141	141	Natural variant	ID=VAR_065241;Note=In AICSR%3B reduced activity. L->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18182448;Dbxref=dbSNP:rs121912813,PMID:18182448
CYP11A1	P05108	90	141	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N9Y
CYP11A1	P05108	90	141	96	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N9Y
CYP11A1	P05108	90	141	104	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N9Y
CYP11A1	P05108	90	141	124	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N9Y
CYP11A1	P05108	90	141	139	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N9Y
DIAPH2	O60879	44	55	1	1101	Chain	ID=PRO_0000194895;Note=Protein diaphanous homolog 2
DIAPH2	O60879	114	149	1	1101	Chain	ID=PRO_0000194895;Note=Protein diaphanous homolog 2
DIAPH2	O60879	114	149	98	464	Domain	Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579
DIAPH2	O60879	44	55	45	55	Alternative sequence	ID=VSP_012955;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DIAPH2	O60879	114	149	149	149	Alternative sequence	ID=VSP_012956;Note=In isoform 3. S->SIVGSKVT;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYP17A1	P05093	251	323	1	508	Chain	ID=PRO_0000051931;Note=Steroid 17-alpha-hydroxylase/17%2C20 lyase
CYP17A1	P05093	222	251	1	508	Chain	ID=PRO_0000051931;Note=Steroid 17-alpha-hydroxylase/17%2C20 lyase
CYP17A1	P05093	222	251	220	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP17A1	P05093	251	323	228	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP17A1	P05093	222	251	228	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP17A1	P05093	251	323	262	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP17A1	P05093	251	323	282	284	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UYS
CYP17A1	P05093	251	323	285	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP17A1	P05093	251	323	289	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP17A1	P05093	251	323	322	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IRQ
CYP1A1	P04798	389	417	1	512	Chain	ID=PRO_0000051627;Note=Cytochrome P450 1A1
CYP1A1	P04798	389	417	1	512	Chain	ID=PRO_0000051627;Note=Cytochrome P450 1A1
CYP1A1	P04798	389	417	1	512	Chain	ID=PRO_0000051627;Note=Cytochrome P450 1A1
CYP1A1	P04798	389	417	190	512	Alternative sequence	ID=VSP_053365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
CYP1A1	P04798	389	417	190	512	Alternative sequence	ID=VSP_053365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
CYP1A1	P04798	389	417	190	512	Alternative sequence	ID=VSP_053365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
CYP1A1	P04798	389	417	394	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	394	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	394	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	406	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	406	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	406	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	411	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	411	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP1A1	P04798	389	417	411	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4I8V
CYP46A1	Q9Y6A2	40	66	1	500	Chain	ID=PRO_0000051994;Note=Cholesterol 24-hydroxylase
CYP46A1	Q9Y6A2	194	231	1	500	Chain	ID=PRO_0000051994;Note=Cholesterol 24-hydroxylase
CYP46A1	Q9Y6A2	40	66	1	153	Alternative sequence	ID=VSP_053858;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CYP46A1	Q9Y6A2	40	66	1	97	Alternative sequence	ID=VSP_053859;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CYP46A1	Q9Y6A2	40	66	60	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MDM
CYP46A1	Q9Y6A2	194	231	180	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MDM
CYP46A1	Q9Y6A2	194	231	203	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MDM
CYP46A1	Q9Y6A2	194	231	209	227	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MDM
CYP46A1	Q9Y6A2	194	231	230	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MDM
CPNE1	Q99829	412	491	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	267	287	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	209	238	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	128	152	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	412	491	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	267	287	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	209	238	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	128	152	1	537	Chain	ID=PRO_0000144834;Note=Copine-1
CPNE1	Q99829	209	238	144	228	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE1	Q99829	128	152	144	228	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE1	Q99829	209	238	144	228	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE1	Q99829	128	152	144	228	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE1	Q99829	412	491	285	505	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPNE1	Q99829	267	287	285	505	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPNE1	Q99829	412	491	285	505	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPNE1	Q99829	267	287	285	505	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CPNE1	Q99829	209	238	211	211	Natural variant	ID=VAR_024423;Note=Q->R;Dbxref=dbSNP:rs6579255
CPNE1	Q99829	209	238	211	211	Natural variant	ID=VAR_024423;Note=Q->R;Dbxref=dbSNP:rs6579255
CPNE1	Q99829	209	238	216	216	Mutagenesis	Note=Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation%3B when associated with A-222. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25450385;Dbxref=PMID:25450385
CPNE1	Q99829	209	238	216	216	Mutagenesis	Note=Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation%3B when associated with A-222. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25450385;Dbxref=PMID:25450385
CPNE1	Q99829	209	238	222	222	Mutagenesis	Note=Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation%3B when associated with A-216. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25450385;Dbxref=PMID:25450385
CPNE1	Q99829	209	238	222	222	Mutagenesis	Note=Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation%3B when associated with A-216. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25450385;Dbxref=PMID:25450385
CPNE2	Q96FN4	60	120	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	145	169	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	197	227	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	227	260	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	60	120	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	145	169	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	197	227	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	227	260	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	60	120	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	145	169	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	197	227	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	227	260	1	548	Chain	ID=PRO_0000144836;Note=Copine-2
CPNE2	Q96FN4	60	120	10	115	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	60	120	10	115	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	60	120	10	115	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	145	169	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	197	227	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	227	260	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	145	169	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	197	227	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	227	260	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	145	169	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	197	227	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	227	260	141	246	Domain	Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
CPNE2	Q96FN4	227	260	247	304	Region	Note=Linker region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59108
CPNE2	Q96FN4	227	260	247	304	Region	Note=Linker region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59108
CPNE2	Q96FN4	227	260	247	304	Region	Note=Linker region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P59108
CPNE2	Q96FN4	60	120	1	102	Alternative sequence	ID=VSP_055536;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CPNE2	Q96FN4	60	120	1	102	Alternative sequence	ID=VSP_055536;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CPNE2	Q96FN4	60	120	1	102	Alternative sequence	ID=VSP_055536;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CPNE2	Q96FN4	60	120	100	100	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPNE2	Q96FN4	60	120	100	100	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPNE2	Q96FN4	60	120	100	100	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CR1	P17927	490	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	940	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	490	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	940	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	1515	1648	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	2001	2035	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	490	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	940	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	490	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	940	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	1515	1648	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	2001	2035	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	490	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	940	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	490	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	940	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	1515	1648	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	2001	2035	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
CR1	P17927	490	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	2001	2035	1997	2039	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	2001	2035	1997	2039	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	2001	2035	1997	2039	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1455	1516	Domain	Note=Sushi 23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1455	1516	Domain	Note=Sushi 23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1455	1516	Domain	Note=Sushi 23;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1517	1587	Domain	Note=Sushi 24;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1517	1587	Domain	Note=Sushi 24;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1517	1587	Domain	Note=Sushi 24;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1589	1648	Domain	Note=Sushi 25;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1589	1648	Domain	Note=Sushi 25;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1589	1648	Domain	Note=Sushi 25;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1648	1708	Domain	Note=Sushi 26;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1648	1708	Domain	Note=Sushi 26;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1648	1708	Domain	Note=Sushi 26;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	940	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1540	1540	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1540	1540	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1540	1540	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1605	1605	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1605	1605	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	1515	1648	1605	1605	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CR1	P17927	490	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	490	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	940	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1519	1568	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1519	1568	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1519	1568	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1548	1585	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1548	1585	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1548	1585	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1591	1633	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1591	1633	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1591	1633	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1619	1646	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1619	1646	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1619	1646	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
CR1	P17927	1515	1648	1540	1540	Natural variant	ID=VAR_055685;Note=N->S;Dbxref=dbSNP:rs17259045
CR1	P17927	1515	1648	1540	1540	Natural variant	ID=VAR_055685;Note=N->S;Dbxref=dbSNP:rs17259045
CR1	P17927	1515	1648	1540	1540	Natural variant	ID=VAR_055685;Note=N->S;Dbxref=dbSNP:rs17259045
CR1	P17927	1515	1648	1590	1590	Natural variant	ID=VAR_013821;Note=In MCC(b) antigen. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11313284;Dbxref=dbSNP:rs17047660,PMID:11313284
CR1	P17927	1515	1648	1590	1590	Natural variant	ID=VAR_013821;Note=In MCC(b) antigen. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11313284;Dbxref=dbSNP:rs17047660,PMID:11313284
CR1	P17927	1515	1648	1590	1590	Natural variant	ID=VAR_013821;Note=In MCC(b) antigen. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11313284;Dbxref=dbSNP:rs17047660,PMID:11313284
CR1	P17927	1515	1648	1601	1601	Natural variant	ID=VAR_013822;Note=In Sl(2)/Vil antigen and Sl(3) antigen. R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:11896343;Dbxref=dbSNP:rs17047661,PMID:11313284,PMID:11896343
CR1	P17927	1515	1648	1601	1601	Natural variant	ID=VAR_013822;Note=In Sl(2)/Vil antigen and Sl(3) antigen. R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:11896343;Dbxref=dbSNP:rs17047661,PMID:11313284,PMID:11896343
CR1	P17927	1515	1648	1601	1601	Natural variant	ID=VAR_013822;Note=In Sl(2)/Vil antigen and Sl(3) antigen. R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:11896343;Dbxref=dbSNP:rs17047661,PMID:11313284,PMID:11896343
CR1	P17927	1515	1648	1610	1610	Natural variant	ID=VAR_013823;Note=In Sl(3) antigen. S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:11896343,ECO:0000269|PubMed:16710414;Dbxref=dbSNP:rs4844609,PMID:11313284,PMID:11896343,PMID:16710414
CR1	P17927	1515	1648	1610	1610	Natural variant	ID=VAR_013823;Note=In Sl(3) antigen. S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:11896343,ECO:0000269|PubMed:16710414;Dbxref=dbSNP:rs4844609,PMID:11313284,PMID:11896343,PMID:16710414
CR1	P17927	1515	1648	1610	1610	Natural variant	ID=VAR_013823;Note=In Sl(3) antigen. S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:11896343,ECO:0000269|PubMed:16710414;Dbxref=dbSNP:rs4844609,PMID:11313284,PMID:11896343,PMID:16710414
CR1	P17927	1515	1648	1615	1615	Natural variant	ID=VAR_013824;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:8245463;Dbxref=dbSNP:rs6691117,PMID:11313284,PMID:8245463
CR1	P17927	1515	1648	1615	1615	Natural variant	ID=VAR_013824;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:8245463;Dbxref=dbSNP:rs6691117,PMID:11313284,PMID:8245463
CR1	P17927	1515	1648	1615	1615	Natural variant	ID=VAR_013824;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11313284,ECO:0000269|PubMed:8245463;Dbxref=dbSNP:rs6691117,PMID:11313284,PMID:8245463
CR1	P17927	940	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
CR1	P17927	940	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
CR1	P17927	940	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
DKC1	O60832	28	57	2	514	Chain	ID=PRO_0000121983;Note=H/ACA ribonucleoprotein complex subunit DKC1
DKC1	O60832	28	57	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DKC1	O60832	28	57	43	43	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DKC1	O60832	28	57	36	36	Natural variant	ID=VAR_006811;Note=In DKCX. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9590285;Dbxref=dbSNP:rs121912293,PMID:9590285
DKC1	O60832	28	57	37	37	Natural variant	ID=VAR_006812;Note=In DKCX%3B results in mislocalization of the telomerase complex without affecting telomerase activity. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21602826,ECO:0000269|PubMed:9590285;Dbxref=PMID:21602826,PMID:9590285
DKC1	O60832	28	57	38	38	Natural variant	ID=VAR_015674;Note=In HHS. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12437656;Dbxref=dbSNP:rs28936072,PMID:12437656
DKC1	O60832	28	57	39	39	Natural variant	ID=VAR_010077;Note=In DKCX. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10364516;Dbxref=dbSNP:rs121912296,PMID:10364516
DKC1	O60832	28	57	40	40	Natural variant	ID=VAR_006813;Note=In DKCX. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9590285;Dbxref=dbSNP:rs121912292,PMID:9590285
DKC1	O60832	28	57	41	41	Natural variant	ID=VAR_010078;Note=In DKCX. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10364516;Dbxref=dbSNP:rs121912302,PMID:10364516
DKC1	O60832	28	57	49	49	Natural variant	ID=VAR_015675;Note=In HHS%3B increases interaction with SHQ1. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10583221,ECO:0000269|PubMed:19734544,ECO:0000269|PubMed:24914498;Dbxref=dbSNP:rs121912304,PMID:10583221,PMID:19734544,PMID:24914498
DKC1	O60832	28	57	54	54	Natural variant	ID=VAR_080707;Note=In DKCX%3B results in mislocalization of the telomerase complex without affecting telomerase activity. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21602826;Dbxref=PMID:21602826
DKC1	O60832	28	57	56	56	Natural variant	ID=VAR_063821;Note=In DKCX%3B due to a 2 nucleotide inversion. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18802941;Dbxref=dbSNP:rs121912287,PMID:18802941
DKC1	O60832	28	57	37	37	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CRISPLD1	Q9H336	242	289	24	500	Chain	ID=PRO_0000248146;Note=Cysteine-rich secretory protein LCCL domain-containing 1
CRISPLD1	Q9H336	242	289	289	384	Domain	Note=LCCL 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00123
CRISPLD1	Q9H336	242	289	286	286	Natural variant	ID=VAR_027255;Note=A->S;Dbxref=dbSNP:rs1945
DKK2	Q9UBU2	124	176	34	259	Chain	ID=PRO_0000007220;Note=Dickkopf-related protein 2
DKK2	Q9UBU2	124	176	78	127	Region	Note=DKK-type Cys-1
DKK2	Q9UBU2	124	176	146	146	Natural variant	ID=VAR_021966;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17037102,PMID:15489334
DLG3	Q92796	507	565	1	817	Chain	ID=PRO_0000094557;Note=Disks large homolog 3
DLG3	Q92796	623	657	1	817	Chain	ID=PRO_0000094557;Note=Disks large homolog 3
DLG3	Q92796	507	565	501	571	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
DLG3	Q92796	623	657	627	802	Domain	Note=Guanylate kinase-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00100
PDSS2	Q86YH6	336	347	1	399	Chain	ID=PRO_0000123978;Note=Decaprenyl-diphosphate synthase subunit 2
PDSS2	Q86YH6	292	336	1	399	Chain	ID=PRO_0000123978;Note=Decaprenyl-diphosphate synthase subunit 2
PDSS2	Q86YH6	234	292	1	399	Chain	ID=PRO_0000123978;Note=Decaprenyl-diphosphate synthase subunit 2
PDSS2	Q86YH6	210	234	1	399	Chain	ID=PRO_0000123978;Note=Decaprenyl-diphosphate synthase subunit 2
PDSS2	Q86YH6	234	292	211	240	Alternative sequence	ID=VSP_017098;Note=In isoform 2. VVELLASALMDLVQGVYHENSTSKESYITD->SFSFNGPIAIYQMGDCESAWILSKHPRALS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDSS2	Q86YH6	210	234	211	240	Alternative sequence	ID=VSP_017098;Note=In isoform 2. VVELLASALMDLVQGVYHENSTSKESYITD->SFSFNGPIAIYQMGDCESAWILSKHPRALS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDSS2	Q86YH6	336	347	241	399	Alternative sequence	ID=VSP_017099;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDSS2	Q86YH6	292	336	241	399	Alternative sequence	ID=VSP_017099;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDSS2	Q86YH6	234	292	241	399	Alternative sequence	ID=VSP_017099;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PDSS2	Q86YH6	292	336	335	335	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSTF3	Q12996	43	75	2	717	Chain	ID=PRO_0000205722;Note=Cleavage stimulation factor subunit 3
CSTF3	Q12996	43	75	45	77	Repeat	Note=HAT 1
CSTF3	Q12996	43	75	44	44	Alternative sequence	ID=VSP_045675;Note=In isoform 3. N->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CSTF3	Q12996	43	75	45	717	Alternative sequence	ID=VSP_045676;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CTTNBP2NL	Q9P2B4	110	146	1	639	Chain	ID=PRO_0000226997;Note=CTTNBP2 N-terminal-like protein
CTTNBP2NL	Q9P2B4	110	146	87	285	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DMXL2	Q8TDJ6	2820	2846	1	3036	Chain	ID=PRO_0000223324;Note=DmX-like protein 2
DMXL2	Q8TDJ6	1557	1594	1	3036	Chain	ID=PRO_0000223324;Note=DmX-like protein 2
DMXL2	Q8TDJ6	921	997	1	3036	Chain	ID=PRO_0000223324;Note=DmX-like protein 2
DMXL2	Q8TDJ6	2820	2846	2804	2843	Repeat	Note=WD 12
DMXL2	Q8TDJ6	921	997	944	944	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
DMXL2	Q8TDJ6	921	997	945	945	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
DMXL2	Q8TDJ6	1557	1594	922	1557	Alternative sequence	ID=VSP_043015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DMXL2	Q8TDJ6	921	997	922	1557	Alternative sequence	ID=VSP_043015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DMXL2	Q8TDJ6	921	997	974	974	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYP4A11	Q02928	112	127	5	519	Chain	ID=PRO_0000003580;Note=Cytochrome P450 4A11
CREB1	P16220	87	101	1	341	Chain	ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1
CREB1	P16220	182	243	1	341	Chain	ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1
CREB1	P16220	87	101	101	160	Domain	Note=KID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00312
CREB1	P16220	87	101	88	101	Alternative sequence	ID=VSP_000596;Note=In isoform CREB-B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1831258,ECO:0000303|PubMed:2974179;Dbxref=PMID:1831258,PMID:2974179
CREB1	P16220	182	243	162	272	Alternative sequence	ID=VSP_043914;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15579595;Dbxref=PMID:15579595
CREB1	P16220	182	243	184	184	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CREB1	P16220	182	243	188	188	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CREB1	P16220	182	243	195	195	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CREB1	P16220	182	243	210	210	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNAJC21	Q5F1R6	105	146	1	531	Chain	ID=PRO_0000281475;Note=DnaJ homolog subfamily C member 21
DNAJC21	Q5F1R6	328	380	1	531	Chain	ID=PRO_0000281475;Note=DnaJ homolog subfamily C member 21
DNAJC21	Q5F1R6	328	380	314	338	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
DNAJC21	Q5F1R6	328	380	225	375	Compositional bias	Note=Glu-rich
DNAJC21	Q5F1R6	328	380	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231
DNAJC24	Q6P3W2	83	106	1	149	Chain	ID=PRO_0000082622;Note=DnaJ homolog subfamily C member 24
DNAJC24	Q6P3W2	83	106	93	148	Zinc finger	Note=DPH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00456
DNAJC24	Q6P3W2	83	106	84	149	Alternative sequence	ID=VSP_056274;Note=In isoform 2. EDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN->GS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAJC24	Q6P3W2	83	106	77	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	92	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	106	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
CRIP2	P52943	65	112	1	208	Chain	ID=PRO_0000075710;Note=Cysteine-rich protein 2
CRIP2	P52943	65	112	63	73	Compositional bias	Note=Gly-rich
CRIP2	P52943	65	112	104	104	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
DLEC1	Q9Y238	187	224	1	1755	Chain	ID=PRO_0000079929;Note=Deleted in lung and esophageal cancer protein 1
DLEC1	Q9Y238	420	478	1	1755	Chain	ID=PRO_0000079929;Note=Deleted in lung and esophageal cancer protein 1
DLEC1	Q9Y238	1568	1622	1	1755	Chain	ID=PRO_0000079929;Note=Deleted in lung and esophageal cancer protein 1
DLEC1	Q9Y238	1568	1622	886	1755	Alternative sequence	ID=VSP_051849;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DLEC1	Q9Y238	187	224	192	192	Natural variant	ID=VAR_056861;Note=S->F;Dbxref=dbSNP:rs34012183
C19orf57	Q0VDD7	588	618	1	668	Chain	ID=PRO_0000295737;Note=Uncharacterized protein C19orf57
C19orf57	Q0VDD7	131	556	1	668	Chain	ID=PRO_0000295737;Note=Uncharacterized protein C19orf57
C19orf57	Q0VDD7	131	556	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
C19orf57	Q0VDD7	588	618	588	619	Alternative sequence	ID=VSP_027044;Note=In isoform 2. RTFVGIQASEASRMEDATNVVRGLIVELSNLN->S;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
C19orf57	Q0VDD7	131	556	267	267	Natural variant	ID=VAR_033356;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2305775,PMID:15489334
C19orf57	Q0VDD7	131	556	500	500	Natural variant	ID=VAR_033357;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3803892,PMID:15489334
C19orf57	Q0VDD7	131	556	491	491	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
TMEM63C	Q9P1W3	355	395	1	806	Chain	ID=PRO_0000280730;Note=Calcium permeable stress-gated cation channel 1
C20orf96	Q9NUD7	275	304	1	363	Chain	ID=PRO_0000079450;Note=Uncharacterized protein C20orf96
C20orf96	Q9NUD7	275	304	109	329	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CTBP1	Q13363	113	182	1	440	Chain	ID=PRO_0000076041;Note=C-terminal-binding protein 1
CTBP1	Q13363	113	182	180	185	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
CTBP1	Q13363	113	182	134	134	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-138%3B A-141 and A-150. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	138	138	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-134%3B A-141 and A-150. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	141	142	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-163 and A-171. RR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	141	141	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-134%3B A-138 and A-150. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	150	150	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-134%3B A-138 and A-141. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	163	163	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-141%3B A-142 and A-171. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	171	171	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with A-141%3B A-142 and A-163. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	181	181	Mutagenesis	Note=Strongly reduces E1A binding%3B when associated with V-183 and A-204. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12419229;Dbxref=PMID:12419229
CTBP1	Q13363	113	182	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MX3
CTBP1	Q13363	113	182	121	124	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4U6S
CTBP1	Q13363	113	182	125	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MX3
CTBP1	Q13363	113	182	143	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MX3
CTBP1	Q13363	113	182	159	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MX3
CTBP1	Q13363	113	182	166	168	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MX3
CTBP1	Q13363	113	182	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MX3
SLC44A5	Q8NCS7	4	17	1	719	Chain	ID=PRO_0000191726;Note=Choline transporter-like protein 5
SLC44A5	Q8NCS7	4	17	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A5	Q8NCS7	4	17	1	42	Alternative sequence	ID=VSP_059802;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CUEDC1	Q9NWM3	289	313	1	386	Chain	ID=PRO_0000079559;Note=CUE domain-containing protein 1
CUEDC1	Q9NWM3	261	289	1	386	Chain	ID=PRO_0000079559;Note=CUE domain-containing protein 1
CUEDC1	Q9NWM3	289	313	1	386	Chain	ID=PRO_0000079559;Note=CUE domain-containing protein 1
CUEDC1	Q9NWM3	261	289	1	386	Chain	ID=PRO_0000079559;Note=CUE domain-containing protein 1
CUEDC1	Q9NWM3	289	313	1	386	Chain	ID=PRO_0000079559;Note=CUE domain-containing protein 1
CUEDC1	Q9NWM3	261	289	1	386	Chain	ID=PRO_0000079559;Note=CUE domain-containing protein 1
CUEDC2	Q9H467	137	198	1	287	Chain	ID=PRO_0000282992;Note=CUE domain-containing protein 2
CUEDC2	Q9H467	137	198	144	187	Domain	Note=CUE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00468
CUL4A	Q13619	225	255	1	759	Chain	ID=PRO_0000119795;Note=Cullin-4A
CUL4A	Q13619	510	546	1	759	Chain	ID=PRO_0000119795;Note=Cullin-4A
CUL4A	Q13619	546	584	1	759	Chain	ID=PRO_0000119795;Note=Cullin-4A
CUL4A	Q13619	677	728	1	759	Chain	ID=PRO_0000119795;Note=Cullin-4A
CUL4A	Q13619	677	728	705	705	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13616
CUL4A	Q13619	225	255	227	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	225	255	232	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	510	546	489	513	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	510	546	522	529	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	510	546	530	532	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	510	546	545	559	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	546	584	545	559	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	546	584	564	566	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	546	584	571	573	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	546	584	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	677	728	678	706	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	677	728	707	711	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	677	728	713	722	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL4A	Q13619	677	728	723	725	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYE
CUL1	Q13616	161	178	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	361	397	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	449	493	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	602	633	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	633	649	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	161	178	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	361	397	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	449	493	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	602	633	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	633	649	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	161	178	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	361	397	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	449	493	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	602	633	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	633	649	1	776	Chain	ID=PRO_0000119787;Note=Cullin-1
CUL1	Q13616	161	178	159	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	159	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	159	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	168	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	168	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	168	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	172	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	172	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	172	177	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	178	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	178	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	161	178	178	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	359	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	359	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	359	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	363	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	363	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	363	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	383	387	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	383	387	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	383	387	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	389	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	389	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	361	397	389	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	439	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	439	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	439	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	459	475	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	459	475	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	459	475	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	482	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	482	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	449	493	482	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	600	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	600	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	600	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	605	612	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	605	612	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	605	612	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	613	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	613	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	613	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	616	621	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	616	621	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	616	621	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	622	628	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	622	628	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	622	628	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	633	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	633	649	633	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	633	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	633	649	633	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	602	633	633	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	633	649	633	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	633	649	646	648	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	633	649	646	648	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL1	Q13616	633	649	646	648	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ
CUL9	Q8IWT3	1386	1446	1	2517	Chain	ID=PRO_0000119815;Note=Cullin-9
CUL9	Q8IWT3	1483	1544	1	2517	Chain	ID=PRO_0000119815;Note=Cullin-9
CUL9	Q8IWT3	2141	2196	1	2517	Chain	ID=PRO_0000119815;Note=Cullin-9
CUL9	Q8IWT3	2141	2196	2140	2203	Zinc finger	Note=IBR-type
CUL9	Q8IWT3	2141	2196	2180	2180	Natural variant	ID=VAR_048845;Note=T->I;Dbxref=dbSNP:rs11962520
CRTAP	O75718	264	307	27	401	Chain	ID=PRO_0000006319;Note=Cartilage-associated protein
CRTAP	O75718	356	384	27	401	Chain	ID=PRO_0000006319;Note=Cartilage-associated protein
CRTAP	O75718	356	384	363	363	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
C19orf47	Q8N9M1	183	234	1	422	Chain	ID=PRO_0000291860;Note=Uncharacterized protein C19orf47
C19orf47	Q8N9M1	137	183	1	422	Chain	ID=PRO_0000291860;Note=Uncharacterized protein C19orf47
C19orf47	Q8N9M1	137	183	151	151	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
C19orf47	Q8N9M1	137	183	1	141	Alternative sequence	ID=VSP_026276;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KCNIP3	Q9Y2W7	149	185	1	256	Chain	ID=PRO_0000073814;Note=Calsenilin
KCNIP3	Q9Y2W7	149	185	126	161	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
KCNIP3	Q9Y2W7	149	185	162	197	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
KCNIP3	Q9Y2W7	149	185	175	186	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
KCNIP3	Q9Y2W7	149	185	170	170	Natural variant	ID=VAR_035463;Note=In a breast cancer sample%3B somatic mutation. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
KCNIP3	Q9Y2W7	149	185	179	179	Natural variant	ID=VAR_035464;Note=In a breast cancer sample%3B somatic mutation. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
KCNIP3	Q9Y2W7	149	185	182	182	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCNIP3	Q9Y2W7	149	185	182	182	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
KCNIP3	Q9Y2W7	149	185	164	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E6W
KCNIP3	Q9Y2W7	149	185	179	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E6W
KCNIP3	Q9Y2W7	149	185	184	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E6W
CSF1R	P07333	773	814	20	972	Chain	ID=PRO_0000016765;Note=Macrophage colony-stimulating factor 1 receptor
CSF1R	P07333	584	619	20	972	Chain	ID=PRO_0000016765;Note=Macrophage colony-stimulating factor 1 receptor
CSF1R	P07333	773	814	539	972	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF1R	P07333	584	619	539	972	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF1R	P07333	773	814	582	910	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSF1R	P07333	584	619	582	910	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSF1R	P07333	584	619	588	596	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSF1R	P07333	773	814	796	818	Region	Note=Activation loop
CSF1R	P07333	773	814	778	778	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
CSF1R	P07333	584	619	616	616	Binding site	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSF1R	P07333	773	814	809	809	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20489731;Dbxref=PMID:20489731
CSF1R	P07333	773	814	307	972	Alternative sequence	ID=VSP_047758;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
CSF1R	P07333	584	619	307	972	Alternative sequence	ID=VSP_047758;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
CSF1R	P07333	584	619	585	619	Natural variant	ID=VAR_067396;Note=In HDLS. GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22197934;Dbxref=PMID:22197934
CSF1R	P07333	584	619	589	589	Natural variant	ID=VAR_067397;Note=In HDLS. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22197934;Dbxref=dbSNP:rs281860268,PMID:22197934
CSF1R	P07333	773	814	774	814	Natural variant	ID=VAR_067403;Note=In HDLS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22197934;Dbxref=PMID:22197934
CSF1R	P07333	773	814	775	775	Natural variant	ID=VAR_067404;Note=In HDLS%3B impairs autophosphorylation upon stimulation with CSF1. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22197934;Dbxref=dbSNP:rs281860273,PMID:22197934
CSF1R	P07333	773	814	794	794	Natural variant	ID=VAR_067405;Note=In HDLS. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22197934;Dbxref=dbSNP:rs281860274,PMID:22197934
CSF1R	P07333	773	814	802	802	Mutagenesis	Note=Constitutive kinase activity. Loss of inhibition by imatinib. D->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10340379,ECO:0000269|PubMed:16170366;Dbxref=PMID:10340379,PMID:16170366
CSF1R	P07333	773	814	809	809	Mutagenesis	Note=Reduced kinase activity. Reduced interaction with SRC%2C FYN and YES1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7681396;Dbxref=PMID:7681396
CSF1R	P07333	584	619	581	590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	584	619	592	601	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	584	619	605	607	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	584	619	612	618	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	781	783	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	785	787	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	788	790	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	791	794	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	798	800	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	803	805	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
CSF1R	P07333	773	814	806	808	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LCO
CSF1R	P07333	773	814	809	811	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I1M
COPS6	Q7L5N1	67	111	1	327	Chain	ID=PRO_0000194860;Note=COP9 signalosome complex subunit 6
COPS6	Q7L5N1	141	162	1	327	Chain	ID=PRO_0000194860;Note=COP9 signalosome complex subunit 6
COPS6	Q7L5N1	162	178	1	327	Chain	ID=PRO_0000194860;Note=COP9 signalosome complex subunit 6
COPS6	Q7L5N1	67	111	41	174	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS6	Q7L5N1	141	162	41	174	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS6	Q7L5N1	162	178	41	174	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS6	Q7L5N1	67	111	69	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	67	111	80	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	67	111	91	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	67	111	97	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	67	111	102	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	141	162	133	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	141	162	143	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	141	162	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	141	162	150	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
COPS6	Q7L5N1	141	162	160	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R14
COPS6	Q7L5N1	162	178	160	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R14
COPS6	Q7L5N1	162	178	165	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QFT
C20orf27	Q9GZN8	100	141	2	174	Chain	ID=PRO_0000079419;Note=UPF0687 protein C20orf27
CLSTN3	Q9BQT9	21	62	20	956	Chain	ID=PRO_0000004026;Note=Calsyntenin-3
CLSTN3	Q9BQT9	197	247	20	956	Chain	ID=PRO_0000004026;Note=Calsyntenin-3
CLSTN3	Q9BQT9	495	513	20	956	Chain	ID=PRO_0000004026;Note=Calsyntenin-3
CLSTN3	Q9BQT9	691	748	20	956	Chain	ID=PRO_0000004026;Note=Calsyntenin-3
CLSTN3	Q9BQT9	21	62	20	847	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN3	Q9BQT9	197	247	20	847	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN3	Q9BQT9	495	513	20	847	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN3	Q9BQT9	691	748	20	847	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN3	Q9BQT9	21	62	29	145	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CLSTN3	Q9BQT9	197	247	146	246	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CLSTN3	Q9BQT9	495	513	507	507	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN3	Q9BQT9	691	748	740	740	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSTN3	Q9BQT9	21	62	1	21	Alternative sequence	ID=VSP_043748;Note=In isoform 2. MTLLLLPLLLASLLASCSCNK->MVLGCELSGSTRVVVGVEALLTGASSPLPGVGP;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15037614,ECO:0000303|PubMed:9872452;Dbxref=PMID:15037614,PMID:9872452
CLSTN3	Q9BQT9	197	247	209	209	Natural variant	ID=VAR_048583;Note=S->G;Dbxref=dbSNP:rs7302230
CTC1	Q2NKJ3	978	1003	1	1217	Chain	ID=PRO_0000287181;Note=CST complex subunit CTC1
CTC1	Q2NKJ3	359	402	1	1217	Chain	ID=PRO_0000287181;Note=CST complex subunit CTC1
CTC1	Q2NKJ3	978	1003	985	985	Natural variant	ID=VAR_067376;Note=In CRMCC1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22267198,ECO:0000269|PubMed:22387016;Dbxref=PMID:22267198,PMID:22387016
CTC1	Q2NKJ3	978	1003	987	987	Natural variant	ID=VAR_067377;Note=In CRMCC1. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22267198;Dbxref=dbSNP:rs202138550,PMID:22267198
CTTNBP2	Q8WZ74	1548	1582	1	1663	Chain	ID=PRO_0000227002;Note=Cortactin-binding protein 2
CTTNBP2	Q8WZ74	1116	1145	1	1663	Chain	ID=PRO_0000227002;Note=Cortactin-binding protein 2
CTTNBP2	Q8WZ74	841	926	1	1663	Chain	ID=PRO_0000227002;Note=Cortactin-binding protein 2
CTTNBP2	Q8WZ74	841	926	842	871	Repeat	Note=ANK 5
CTTNBP2	Q8WZ74	841	926	912	942	Repeat	Note=ANK 6
SLC44A1	Q8WWI5	470	498	2	657	Chain	ID=PRO_0000191712;Note=Choline transporter-like protein 1
SLC44A1	Q8WWI5	498	544	2	657	Chain	ID=PRO_0000191712;Note=Choline transporter-like protein 1
SLC44A1	Q8WWI5	544	623	2	657	Chain	ID=PRO_0000191712;Note=Choline transporter-like protein 1
SLC44A1	Q8WWI5	623	650	2	657	Chain	ID=PRO_0000191712;Note=Choline transporter-like protein 1
SLC44A1	Q8WWI5	470	498	402	537	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	498	544	402	537	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	498	544	538	558	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	544	623	538	558	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	544	623	559	566	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	544	623	567	587	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	544	623	588	653	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	623	650	588	653	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC44A1	Q8WWI5	470	498	474	492	Compositional bias	Note=Cys-rich
SLC44A1	Q8WWI5	623	650	644	644	Natural variant	ID=VAR_048837;Note=S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11698453;Dbxref=dbSNP:rs3199966,PMID:11698453
CIT	O14578	1155	1202	1	2027	Chain	ID=PRO_0000085908;Note=Citron Rho-interacting kinase
CIT	O14578	926	944	1	2027	Chain	ID=PRO_0000085908;Note=Citron Rho-interacting kinase
CIT	O14578	555	612	1	2027	Chain	ID=PRO_0000085908;Note=Citron Rho-interacting kinase
CIT	O14578	251	319	1	2027	Chain	ID=PRO_0000085908;Note=Citron Rho-interacting kinase
CIT	O14578	138	172	1	2027	Chain	ID=PRO_0000085908;Note=Citron Rho-interacting kinase
CIT	O14578	251	319	97	360	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CIT	O14578	138	172	97	360	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CIT	O14578	1155	1202	1091	1302	Region	Note=Interaction with Rho/Rac
CIT	O14578	1155	1202	453	1297	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CIT	O14578	926	944	453	1297	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CIT	O14578	555	612	453	1297	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CIT	O14578	555	612	582	582	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CIT	O14578	1155	1202	1196	1196	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49025
CIT	O14578	251	319	1	467	Alternative sequence	ID=VSP_014507;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
CIT	O14578	138	172	1	467	Alternative sequence	ID=VSP_014507;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10231032;Dbxref=PMID:10231032
CIT	O14578	1155	1202	483	2027	Alternative sequence	ID=VSP_012435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CIT	O14578	926	944	483	2027	Alternative sequence	ID=VSP_012435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CIT	O14578	555	612	483	2027	Alternative sequence	ID=VSP_012435;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CXorf38	Q8TB03	207	267	1	319	Chain	ID=PRO_0000079732;Note=Uncharacterized protein CXorf38
CXorf38	Q8TB03	117	157	1	319	Chain	ID=PRO_0000079732;Note=Uncharacterized protein CXorf38
CXorf38	Q8TB03	117	157	1	119	Alternative sequence	ID=VSP_014620;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CXorf38	Q8TB03	117	157	118	155	Alternative sequence	ID=VSP_014621;Note=In isoform 3. AFMPRGLADKQGPEECDAVALLSLINSCDHFVVDRKKV->GLDLLSRLECSGESELIATLNSWAQAILLPQPLEYLGL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CXorf38	Q8TB03	207	267	156	319	Alternative sequence	ID=VSP_014622;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CXorf38	Q8TB03	117	157	156	319	Alternative sequence	ID=VSP_014622;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DNMT1	P26358	949	1022	1	1616	Chain	ID=PRO_0000088034;Note=DNA (cytosine-5)-methyltransferase 1
DNMT1	P26358	891	948	1	1616	Chain	ID=PRO_0000088034;Note=DNA (cytosine-5)-methyltransferase 1
DNMT1	P26358	949	1022	972	1100	Domain	Note=BAH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370
DNMT1	P26358	891	948	891	891	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21947282;Dbxref=PMID:21947282
DNMT1	P26358	949	1022	957	957	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21947282;Dbxref=PMID:21947282
DNMT1	P26358	949	1022	961	961	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21947282;Dbxref=PMID:21947282
DNMT1	P26358	949	1022	975	975	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21947282;Dbxref=PMID:21947282
DNMT1	P26358	891	948	889	891	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	891	948	894	905	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	891	948	912	916	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	891	948	921	928	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	891	948	931	934	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	891	948	938	941	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	949	1022	966	968	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	949	1022	973	975	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	949	1022	976	980	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	949	1022	992	1001	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	949	1022	1005	1008	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
DNMT1	P26358	949	1022	1015	1020	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SWR
C19orf44	Q9H6X5	546	578	1	657	Chain	ID=PRO_0000291921;Note=Uncharacterized protein C19orf44
TMEM63A	O94886	729	750	1	807	Chain	ID=PRO_0000280725;Note=CSC1-like protein 1
TMEM63A	O94886	524	544	1	807	Chain	ID=PRO_0000280725;Note=CSC1-like protein 1
TMEM63A	O94886	495	523	1	807	Chain	ID=PRO_0000280725;Note=CSC1-like protein 1
TMEM63A	O94886	362	407	1	807	Chain	ID=PRO_0000280725;Note=CSC1-like protein 1
TMEM63A	O94886	249	275	1	807	Chain	ID=PRO_0000280725;Note=CSC1-like protein 1
TMEM63A	O94886	524	544	508	528	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63A	O94886	495	523	508	528	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM63A	O94886	729	750	739	739	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YT8
DLGAP4	Q9Y2H0	452	469	1	992	Chain	ID=PRO_0000174297;Note=Disks large-associated protein 4
DLGAP4	Q9Y2H0	452	469	1	992	Chain	ID=PRO_0000174297;Note=Disks large-associated protein 4
DLGAP4	Q9Y2H0	452	469	1	539	Alternative sequence	ID=VSP_034910;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DLGAP4	Q9Y2H0	452	469	1	539	Alternative sequence	ID=VSP_034910;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CSF3R	Q99062	21	120	1	24	Signal peptide	.
CSF3R	Q99062	21	120	1	24	Signal peptide	.
CSF3R	Q99062	491	525	25	836	Chain	ID=PRO_0000010874;Note=Granulocyte colony-stimulating factor receptor
CSF3R	Q99062	428	491	25	836	Chain	ID=PRO_0000010874;Note=Granulocyte colony-stimulating factor receptor
CSF3R	Q99062	21	120	25	836	Chain	ID=PRO_0000010874;Note=Granulocyte colony-stimulating factor receptor
CSF3R	Q99062	491	525	25	836	Chain	ID=PRO_0000010874;Note=Granulocyte colony-stimulating factor receptor
CSF3R	Q99062	428	491	25	836	Chain	ID=PRO_0000010874;Note=Granulocyte colony-stimulating factor receptor
CSF3R	Q99062	21	120	25	836	Chain	ID=PRO_0000010874;Note=Granulocyte colony-stimulating factor receptor
CSF3R	Q99062	491	525	25	627	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	428	491	25	627	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	25	627	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	491	525	25	627	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	428	491	25	627	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	25	627	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	25	117	Domain	Note=Ig-like C2-type
CSF3R	Q99062	21	120	25	117	Domain	Note=Ig-like C2-type
CSF3R	Q99062	428	491	334	430	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CSF3R	Q99062	428	491	334	430	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CSF3R	Q99062	491	525	431	528	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CSF3R	Q99062	428	491	431	528	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CSF3R	Q99062	491	525	431	528	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CSF3R	Q99062	428	491	431	528	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CSF3R	Q99062	21	120	51	51	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	51	51	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	93	93	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	93	93	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	428	491	474	474	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	428	491	474	474	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSF3R	Q99062	21	120	26	52	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16492764;Dbxref=PMID:16492764
CSF3R	Q99062	21	120	26	52	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16492764;Dbxref=PMID:16492764
CSF3R	Q99062	21	120	46	101	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16492764;Dbxref=PMID:16492764
CSF3R	Q99062	21	120	46	101	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16492764;Dbxref=PMID:16492764
CSF3R	Q99062	428	491	440	440	Natural variant	ID=VAR_014329;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3918020
CSF3R	Q99062	428	491	440	440	Natural variant	ID=VAR_014329;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3918020
CSF3R	Q99062	491	525	510	510	Natural variant	ID=VAR_014330;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3917991
CSF3R	Q99062	491	525	510	510	Natural variant	ID=VAR_014330;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3917991
CSF3R	Q99062	21	120	29	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	29	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	34	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	34	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	42	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	42	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	62	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	62	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	85	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	85	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	94	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
CSF3R	Q99062	21	120	94	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D9Q
DLL4	Q9NR61	131	219	27	685	Chain	ID=PRO_0000007512;Note=Delta-like protein 4
DLL4	Q9NR61	131	219	27	529	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DLL4	Q9NR61	131	219	173	217	Domain	Note=DSL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00377
DLL4	Q9NR61	131	219	218	251	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
DLL4	Q9NR61	131	219	185	187	Region	Note=Interaction with Notch1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZHH1
DLL4	Q9NR61	131	219	191	195	Region	Note=Interaction with Notch1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZHH1
DLL4	Q9NR61	131	219	216	216	Site	Note=Interaction with Notch1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZHH1
DLL4	Q9NR61	131	219	183	183	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DLL4	Q9NR61	131	219	205	205	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DLL4	Q9NR61	131	219	175	184	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:D3ZHH1,ECO:0000255|PROSITE-ProRule:PRU00377
DLL4	Q9NR61	131	219	188	200	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:D3ZHH1,ECO:0000255|PROSITE-ProRule:PRU00377
DLL4	Q9NR61	131	219	208	217	Disulfide bond	Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:D3ZHH1,ECO:0000255|PROSITE-ProRule:PRU00377
DLL4	Q9NR61	131	219	186	186	Natural variant	ID=VAR_075859;Note=In AOS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299364;Dbxref=dbSNP:rs796065348,PMID:26299364
DLL4	Q9NR61	131	219	195	195	Natural variant	ID=VAR_075860;Note=In AOS6. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26299364;Dbxref=dbSNP:rs796065351,PMID:26299364
DLL4	Q9NR61	131	219	131	133	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	136	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	139	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	151	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	156	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	166	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	179	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	196	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
DLL4	Q9NR61	131	219	212	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MVX
CSK	P41240	185	207	2	450	Chain	ID=PRO_0000088070;Note=Tyrosine-protein kinase CSK
CSK	P41240	185	207	2	450	Chain	ID=PRO_0000088070;Note=Tyrosine-protein kinase CSK
CSK	P41240	185	207	2	450	Chain	ID=PRO_0000088070;Note=Tyrosine-protein kinase CSK
CSK	P41240	185	207	195	449	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSK	P41240	185	207	195	449	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSK	P41240	185	207	195	449	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSK	P41240	185	207	201	209	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSK	P41240	185	207	201	209	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSK	P41240	185	207	201	209	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSK	P41240	185	207	192	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BYG
CSK	P41240	185	207	192	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BYG
CSK	P41240	185	207	192	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BYG
CSK	P41240	185	207	195	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BYG
CSK	P41240	185	207	195	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BYG
CSK	P41240	185	207	195	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BYG
DMPK	Q09013	559	589	1	629	Chain	ID=PRO_0000085924;Note=Myotonin-protein kinase
DMPK	Q09013	304	392	1	629	Chain	ID=PRO_0000085924;Note=Myotonin-protein kinase
DMPK	Q09013	235	304	1	629	Chain	ID=PRO_0000085924;Note=Myotonin-protein kinase
DMPK	Q09013	559	589	1	590	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DMPK	Q09013	304	392	1	590	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DMPK	Q09013	235	304	1	590	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DMPK	Q09013	304	392	71	339	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DMPK	Q09013	235	304	71	339	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DMPK	Q09013	304	392	340	415	Domain	Note=AGC-kinase C-terminal
DMPK	Q09013	235	304	226	275	Alternative sequence	ID=VSP_042100;Note=In isoform 9. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DMPK	Q09013	304	392	378	382	Alternative sequence	ID=VSP_042101;Note=In isoform 2%2C isoform 4%2C isoform 6 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1310900,ECO:0000303|PubMed:7905855,ECO:0000303|PubMed:8076686;Dbxref=PMID:1310900,PMID:7905855,PMID:8076686
DMPK	Q09013	559	589	536	629	Alternative sequence	ID=VSP_042103;Note=In isoform 5%2C isoform 6 and isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DMPK	Q09013	559	589	550	629	Alternative sequence	ID=VSP_042104;Note=In isoform 3 and isoform 4. LDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP->MAPRPWLWASARWWGQAPCTAATCCSLPGSLGLAYRRRFPCSCSPLFCLVPPPWAALGWWPTPANSPQSGAAQEPPALPEP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8076686;Dbxref=PMID:8076686
DMPK	Q09013	559	589	550	579	Alternative sequence	ID=VSP_042105;Note=In isoform 11. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DMPK	Q09013	235	304	235	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	235	304	240	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	235	304	253	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	235	304	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	235	304	283	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	235	304	293	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	308	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	321	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	325	329	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	330	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	337	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	378	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
DMPK	Q09013	304	392	385	387	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2VD5
RBBP8	Q99708	201	236	1	897	Chain	ID=PRO_0000097179;Note=DNA endonuclease RBBP8
RBBP8	Q99708	714	762	1	897	Chain	ID=PRO_0000097179;Note=DNA endonuclease RBBP8
RBBP8	Q99708	201	236	1	897	Chain	ID=PRO_0000097179;Note=DNA endonuclease RBBP8
RBBP8	Q99708	714	762	1	897	Chain	ID=PRO_0000097179;Note=DNA endonuclease RBBP8
RBBP8	Q99708	201	236	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBBP8	Q99708	201	236	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RBBP8	Q99708	714	762	723	723	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
RBBP8	Q99708	714	762	723	723	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
RBBP8	Q99708	714	762	745	745	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910365;Dbxref=PMID:10910365
RBBP8	Q99708	714	762	745	745	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910365;Dbxref=PMID:10910365
RBBP8	Q99708	714	762	719	719	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBBP8	Q99708	714	762	719	719	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RBBP8	Q99708	714	762	714	714	Alternative sequence	ID=VSP_043220;Note=In isoform 2. S->SMLFYI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBBP8	Q99708	714	762	714	714	Alternative sequence	ID=VSP_043220;Note=In isoform 2. S->SMLFYI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RBBP8	Q99708	714	762	745	745	Mutagenesis	Note=Abrogates dissociation of BRCA1. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910365;Dbxref=PMID:10910365
RBBP8	Q99708	714	762	745	745	Mutagenesis	Note=Abrogates dissociation of BRCA1. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10910365;Dbxref=PMID:10910365
RBBP8	Q99708	714	762	759	759	Mutagenesis	Note=In K12R%3B defects in ability to promoting DNA resection and homologous recombination%3B when associated with R-62%3B R-78%3B R-115%3B R-132%3B R-133%3B R-404%3B R-572%3B R-578%3B R-640%3B R-760 and R-782. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26502057;Dbxref=PMID:26502057
RBBP8	Q99708	714	762	759	759	Mutagenesis	Note=In K12R%3B defects in ability to promoting DNA resection and homologous recombination%3B when associated with R-62%3B R-78%3B R-115%3B R-132%3B R-133%3B R-404%3B R-572%3B R-578%3B R-640%3B R-760 and R-782. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26502057;Dbxref=PMID:26502057
RBBP8	Q99708	714	762	760	760	Mutagenesis	Note=In K12R%3B defects in ability to promoting DNA resection and homologous recombination%3B when associated with R-62%3B R-78%3B R-115%3B R-132%3B R-133%3B R-404%3B R-572%3B R-578%3B R-640%3B R-759 and R-782. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26502057;Dbxref=PMID:26502057
RBBP8	Q99708	714	762	760	760	Mutagenesis	Note=In K12R%3B defects in ability to promoting DNA resection and homologous recombination%3B when associated with R-62%3B R-78%3B R-115%3B R-132%3B R-133%3B R-404%3B R-572%3B R-578%3B R-640%3B R-759 and R-782. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26502057;Dbxref=PMID:26502057
DMXL1	Q9Y485	71	95	1	3027	Chain	ID=PRO_0000223322;Note=DmX-like protein 1
DMXL1	Q9Y485	2163	2227	1	3027	Chain	ID=PRO_0000223322;Note=DmX-like protein 1
DMXL1	Q9Y485	2163	2227	2173	2173	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTDSP1	Q9GZU7	72	107	1	261	Chain	ID=PRO_0000212572;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
CTDSP1	Q9GZU7	107	126	1	261	Chain	ID=PRO_0000212572;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
CTDSP1	Q9GZU7	126	157	1	261	Chain	ID=PRO_0000212572;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
CTDSP1	Q9GZU7	72	107	86	244	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP1	Q9GZU7	107	126	86	244	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP1	Q9GZU7	126	157	86	244	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP1	Q9GZU7	72	107	96	96	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15304220,ECO:0000269|PubMed:17157258;Dbxref=PMID:15304220,PMID:17157258
CTDSP1	Q9GZU7	72	107	98	98	Active site	Note=Proton donor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15304220;Dbxref=PMID:15304220
CTDSP1	Q9GZU7	72	107	96	96	Metal binding	Note=Magnesium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15304220;Dbxref=PMID:15304220
CTDSP1	Q9GZU7	72	107	98	98	Metal binding	Note=Magnesium%3B via carbonyl oxygen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15304220;Dbxref=PMID:15304220
CTDSP1	Q9GZU7	126	157	152	152	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15304220;Dbxref=PMID:15304220
CTDSP1	Q9GZU7	72	107	73	73	Alternative sequence	ID=VSP_045866;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12721286,ECO:0000303|Ref.3;Dbxref=PMID:12721286
CTDSP1	Q9GZU7	72	107	96	96	Mutagenesis	Note=No effect. Completely abolishes phosphatase activity%3B when associated with N-98. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12721286;Dbxref=PMID:12721286
CTDSP1	Q9GZU7	72	107	98	98	Mutagenesis	Note=Completely abolishes phosphatase activity%3B when associated with E-96. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12721286;Dbxref=PMID:12721286
CTDSP1	Q9GZU7	72	107	85	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	72	107	92	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	72	107	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	72	107	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	107	126	102	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	107	126	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	107	126	123	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	126	157	123	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	126	157	135	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	126	157	146	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP1	Q9GZU7	126	157	156	166	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GHT
CTDSP2	O14595	168	230	1	271	Chain	ID=PRO_0000212574;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
CTDSP2	O14595	137	168	1	271	Chain	ID=PRO_0000212574;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
CTDSP2	O14595	118	137	1	271	Chain	ID=PRO_0000212574;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
CTDSP2	O14595	84	118	1	271	Chain	ID=PRO_0000212574;Note=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
CTDSP2	O14595	168	230	97	255	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP2	O14595	137	168	97	255	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP2	O14595	118	137	97	255	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP2	O14595	84	118	97	255	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSP2	O14595	84	118	107	107	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CTDSP2	O14595	84	118	109	109	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
CTDSP2	O14595	84	118	107	107	Metal binding	Note=Magnesium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18058037;Dbxref=PMID:18058037
CTDSP2	O14595	84	118	109	109	Metal binding	Note=Magnesium%3B via carbonyl oxygen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18058037;Dbxref=PMID:18058037
CTDSP2	O14595	168	230	218	218	Metal binding	Note=Magnesium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18058037;Dbxref=PMID:18058037
CTDSP2	O14595	137	168	163	163	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
CTDSP2	O14595	168	230	201	201	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
CTDSP2	O14595	84	118	96	100	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	84	118	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	84	118	110	112	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	118	137	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	84	118	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	118	137	124	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	137	168	134	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	118	137	134	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	137	168	146	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	137	168	157	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	167	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	137	168	167	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	183	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	189	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	192	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	203	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	206	208	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	210	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	220	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	227	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTDSP2	O14595	168	230	230	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Q5E
CTNNA3	Q9UI47	427	458	1	895	Chain	ID=PRO_0000064266;Note=Catenin alpha-3
CWC27	Q6UX04	132	165	2	472	Chain	ID=PRO_0000313647;Note=Spliceosome-associated protein CWC27 homolog
CWC27	Q6UX04	132	165	11	166	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00156
CWC27	Q6UX04	132	165	7	472	Natural variant	ID=VAR_078981;Note=In RPSKA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28285769;Dbxref=PMID:28285769
CWC27	Q6UX04	132	165	143	472	Natural variant	ID=VAR_078982;Note=In RPSKA. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28285769;Dbxref=PMID:28285769
CWC27	Q6UX04	132	165	129	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQ6
CWC27	Q6UX04	132	165	135	137	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQ6
CWC27	Q6UX04	132	165	138	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQ6
CWC27	Q6UX04	132	165	151	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R3E
CWC27	Q6UX04	132	165	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQ6
CWC27	Q6UX04	132	165	160	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HQ6
CXXC1	Q9P0U4	471	508	1	656	Chain	ID=PRO_0000079743;Note=CXXC-type zinc finger protein 1
CXXC1	Q9P0U4	304	340	1	656	Chain	ID=PRO_0000079743;Note=CXXC-type zinc finger protein 1
CXXC1	Q9P0U4	471	508	422	474	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CXXC1	Q9P0U4	304	340	256	317	Compositional bias	Note=Asp/Glu-rich (acidic)
CXXC1	Q9P0U4	304	340	321	359	Compositional bias	Note=Arg/Lys-rich (basic)
CXXC1	Q9P0U4	304	340	340	340	Alternative sequence	ID=VSP_040132;Note=In isoform 2. K->KVMER;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGEF39	Q8N4T4	181	224	1	335	Chain	ID=PRO_0000291864;Note=Rho guanine nucleotide exchange factor 39
ARHGEF39	Q8N4T4	181	224	22	197	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF39	Q8N4T4	181	224	182	186	Alternative sequence	ID=VSP_026283;Note=In isoform 3. RAARL->PVLPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGEF39	Q8N4T4	181	224	187	335	Alternative sequence	ID=VSP_026284;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARG1	P05089	187	221	1	322	Chain	ID=PRO_0000173693;Note=Arginase-1
ARG1	P05089	187	221	217	217	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ARG1	P05089	187	221	204	289	Alternative sequence	ID=VSP_009331;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
ARG1	P05089	187	221	202	202	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARG1	P05089	187	221	184	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEB
ARG1	P05089	187	221	196	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEB
ARG1	P05089	187	221	200	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEB
ARG1	P05089	187	221	208	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEB
ARG1	P05089	187	221	221	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AEB
RAD54L2	Q9Y4B4	160	199	1	1467	Chain	ID=PRO_0000315781;Note=Helicase ARIP4
ARHGEF11	O15085	1325	1357	1	1522	Chain	ID=PRO_0000080928;Note=Rho guanine nucleotide exchange factor 11
ARHGEF11	O15085	1069	1110	1	1522	Chain	ID=PRO_0000080928;Note=Rho guanine nucleotide exchange factor 11
ARHGEF11	O15085	982	1038	1	1522	Chain	ID=PRO_0000080928;Note=Rho guanine nucleotide exchange factor 11
ARHGEF11	O15085	549	559	1	1522	Chain	ID=PRO_0000080928;Note=Rho guanine nucleotide exchange factor 11
ARHGEF11	O15085	170	194	1	1522	Chain	ID=PRO_0000080928;Note=Rho guanine nucleotide exchange factor 11
ARHGEF11	O15085	1069	1110	965	1079	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF11	O15085	982	1038	965	1079	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF11	O15085	1069	1110	1094	1099	Compositional bias	Note=Poly-Pro
ARHGEF11	O15085	549	559	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARHGEF11	O15085	170	194	194	194	Alternative sequence	ID=VSP_042003;Note=In isoform 2. Q->QRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGEF11	O15085	982	1038	981	999	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JHH
ARHGEF11	O15085	982	1038	1002	1004	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JHH
ARHGEF11	O15085	982	1038	1024	1027	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JHH
ARHGEF11	O15085	982	1038	1028	1030	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JHH
ARHGEF11	O15085	982	1038	1031	1035	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JHH
ARHGEF11	O15085	1069	1110	1064	1080	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JHH
ARHGEF25	Q86VW2	242	272	1	580	Chain	ID=PRO_0000322132;Note=Rho guanine nucleotide exchange factor 25
ARHGEF25	Q86VW2	320	346	1	580	Chain	ID=PRO_0000322132;Note=Rho guanine nucleotide exchange factor 25
ARHGEF25	Q86VW2	242	272	160	336	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF25	Q86VW2	320	346	160	336	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF25	Q86VW2	242	272	253	253	Natural variant	ID=VAR_039402;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12547822,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857333,PMID:12547822,PMID:15489334
ARHGEF25	Q86VW2	242	272	242	246	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARHGEF25	Q86VW2	242	272	247	254	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARHGEF25	Q86VW2	242	272	257	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARHGEF25	Q86VW2	242	272	264	266	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARHGEF25	Q86VW2	242	272	268	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARHGEF25	Q86VW2	320	346	316	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARHGEF25	Q86VW2	320	346	339	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RGN
ARPP21	Q9UBL0	265	299	2	812	Chain	ID=PRO_0000064682;Note=cAMP-regulated phosphoprotein 21
ARPP21	Q9UBL0	312	331	2	812	Chain	ID=PRO_0000064682;Note=cAMP-regulated phosphoprotein 21
ARPP21	Q9UBL0	265	299	228	300	Domain	Note=SUZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01009
ARPP21	Q9UBL0	265	299	1	512	Alternative sequence	ID=VSP_029469;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARPP21	Q9UBL0	312	331	1	512	Alternative sequence	ID=VSP_029469;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARPP21	Q9UBL0	265	299	90	812	Alternative sequence	ID=VSP_029472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10931946,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8120638;Dbxref=PMID:10931946,PMID:15489334,PMID:8120638
ARPP21	Q9UBL0	312	331	90	812	Alternative sequence	ID=VSP_029472;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10931946,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8120638;Dbxref=PMID:10931946,PMID:15489334,PMID:8120638
ARPP21	Q9UBL0	265	299	109	812	Alternative sequence	ID=VSP_029473;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARPP21	Q9UBL0	312	331	109	812	Alternative sequence	ID=VSP_029473;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARPP21	Q9UBL0	265	299	266	299	Alternative sequence	ID=VSP_029474;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
ARPP21	Q9UBL0	312	331	312	331	Alternative sequence	ID=VSP_029475;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARPP21	Q9UBL0	312	331	312	312	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARSE	P51690	8	61	1	31	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARSE	P51690	102	143	32	589	Chain	ID=PRO_0000033425;Note=Arylsulfatase E
ARSE	P51690	8	61	32	589	Chain	ID=PRO_0000033425;Note=Arylsulfatase E
ARSE	P51690	8	61	46	46	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSE	P51690	8	61	47	47	Metal binding	Note=Calcium;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARSE	P51690	8	61	58	58	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ARSE	P51690	102	143	125	125	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
ARSE	P51690	8	61	12	12	Natural variant	ID=VAR_007307;Note=In CDPX1. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7720070;Dbxref=dbSNP:rs122460151,PMID:7720070
ARSE	P51690	102	143	111	111	Natural variant	ID=VAR_007308;Note=In CDPX1. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7720070;Dbxref=dbSNP:rs122460153,PMID:7720070
ARSE	P51690	102	143	117	117	Natural variant	ID=VAR_007309;Note=In CDPX1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7720070;Dbxref=dbSNP:rs122460152,PMID:7720070
ARSE	P51690	102	143	137	137	Natural variant	ID=VAR_007310;Note=In CDPX1. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7720070;Dbxref=dbSNP:rs80338711,PMID:7720070
ACTR6	Q9GZN1	62	85	2	396	Chain	ID=PRO_0000089105;Note=Actin-related protein 6
ACTR6	Q9GZN1	172	190	2	396	Chain	ID=PRO_0000089105;Note=Actin-related protein 6
ACTR6	Q9GZN1	191	223	2	396	Chain	ID=PRO_0000089105;Note=Actin-related protein 6
ACTR6	Q9GZN1	172	190	127	182	Alternative sequence	ID=VSP_054637;Note=In isoform 2. AGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTN->GEFKFSLKLSYMTMDMNRVILIKSQNIKWHSWLAQWLTPVTPSVWEAEASRSLEFR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTR6	Q9GZN1	172	190	183	395	Alternative sequence	ID=VSP_054638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTR6	Q9GZN1	191	223	183	395	Alternative sequence	ID=VSP_054638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTR6	Q9GZN1	191	223	218	218	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
C8G	P07360	115	151	21	202	Chain	ID=PRO_0000017881;Note=Complement component C8 gamma chain
C8G	P07360	151	185	21	202	Chain	ID=PRO_0000017881;Note=Complement component C8 gamma chain
C8G	P07360	185	198	21	202	Chain	ID=PRO_0000017881;Note=Complement component C8 gamma chain
C8G	P07360	115	151	96	188	Disulfide bond	.
C8G	P07360	151	185	96	188	Disulfide bond	.
C8G	P07360	185	198	96	188	Disulfide bond	.
C8G	P07360	115	151	118	118	Natural variant	ID=VAR_044319;Note=D->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:2447883,ECO:0000269|PubMed:3676249,ECO:0000269|PubMed:8172891,ECO:0000269|Ref.5;Dbxref=dbSNP:rs7850844,PMID:15489334,PMID:2447883,PMID:3676249,PMID:8172891
C8G	P07360	115	151	124	124	Natural variant	ID=VAR_014669;Note=H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17613,PMID:15489334
C8G	P07360	115	151	117	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	115	151	123	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	115	151	132	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	115	151	145	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	151	185	145	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	151	185	159	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	151	185	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	151	185	179	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	185	198	193	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
C8G	P07360	185	198	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LF7
COL9A2	Q14055	534	597	24	689	Chain	ID=PRO_0000005837;Note=Collagen alpha-2(IX) chain
COL9A2	Q14055	467	516	24	689	Chain	ID=PRO_0000005837;Note=Collagen alpha-2(IX) chain
COL9A2	Q14055	300	318	24	689	Chain	ID=PRO_0000005837;Note=Collagen alpha-2(IX) chain
COL9A2	Q14055	210	228	24	689	Chain	ID=PRO_0000005837;Note=Collagen alpha-2(IX) chain
COL9A2	Q14055	192	210	24	689	Chain	ID=PRO_0000005837;Note=Collagen alpha-2(IX) chain
COL9A2	Q14055	121	139	24	689	Chain	ID=PRO_0000005837;Note=Collagen alpha-2(IX) chain
COL9A2	Q14055	121	139	27	163	Region	Note=Triple-helical region 4 (COL4)
COL9A2	Q14055	467	516	181	519	Region	Note=Triple-helical region 3 (COL3)
COL9A2	Q14055	300	318	181	519	Region	Note=Triple-helical region 3 (COL3)
COL9A2	Q14055	210	228	181	519	Region	Note=Triple-helical region 3 (COL3)
COL9A2	Q14055	192	210	181	519	Region	Note=Triple-helical region 3 (COL3)
COL9A2	Q14055	534	597	520	549	Region	Note=Nonhelical region 3 (NC3)
COL9A2	Q14055	534	597	550	632	Region	Note=Triple-helical region 2 (COL2)
COL9A2	Q14055	534	597	326	689	Natural variant	ID=VAR_079749;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28887846;Dbxref=PMID:28887846
COL9A2	Q14055	467	516	326	689	Natural variant	ID=VAR_079749;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28887846;Dbxref=PMID:28887846
COL9A2	Q14055	534	597	581	581	Natural variant	ID=VAR_020014;Note=V->I;Dbxref=dbSNP:rs3737821
COL9A2	Q14055	534	597	523	549	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CTD
C9	P02748	370	413	22	559	Chain	ID=PRO_0000023602;Note=Complement component C9
C9	P02748	205	290	22	559	Chain	ID=PRO_0000023602;Note=Complement component C9
C9	P02748	205	290	22	265	Chain	ID=PRO_0000023603;Note=Complement component C9a
C9	P02748	370	413	266	559	Chain	ID=PRO_0000023604;Note=Complement component C9b
C9	P02748	205	290	266	559	Chain	ID=PRO_0000023604;Note=Complement component C9b
C9	P02748	370	413	138	509	Domain	Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745
C9	P02748	205	290	138	509	Domain	Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745
C9	P02748	205	290	265	266	Site	Note=Cleavage%3B by thrombin
C9	P02748	205	290	277	277	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:4055801;Dbxref=PMID:16335952,PMID:19159218,PMID:4055801
C9	P02748	205	290	254	255	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8603752;Dbxref=PMID:8603752
C9	P02748	370	413	380	405	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8603752;Dbxref=PMID:8603752
C9	P02748	205	290	279	279	Natural variant	ID=VAR_033802;Note=T->S;Dbxref=dbSNP:rs34625111
C6	P13671	389	430	22	934	Chain	ID=PRO_0000023579;Note=Complement component C6
C6	P13671	389	430	22	934	Chain	ID=PRO_0000023579;Note=Complement component C6
C6	P13671	389	430	176	522	Domain	Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745
C6	P13671	389	430	176	522	Domain	Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745
C6	P13671	389	430	392	392	Glycosylation	Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22267737;Dbxref=PMID:22267737
C6	P13671	389	430	392	392	Glycosylation	Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22267737;Dbxref=PMID:22267737
C6	P13671	389	430	399	420	Disulfide bond	.
C6	P13671	389	430	399	420	Disulfide bond	.
C6	P13671	389	430	397	397	Natural variant	ID=VAR_027647;Note=K->E;Dbxref=dbSNP:rs6896011
C6	P13671	389	430	397	397	Natural variant	ID=VAR_027647;Note=K->E;Dbxref=dbSNP:rs6896011
C6	P13671	389	430	383	389	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	383	389	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	393	407	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	393	407	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	418	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	418	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	426	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
C6	P13671	389	430	426	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T5O
DGAT2	Q96PD7	40	83	1	388	Chain	ID=PRO_0000249045;Note=Diacylglycerol O-acyltransferase 2
DGAT2	Q96PD7	83	119	1	388	Chain	ID=PRO_0000249045;Note=Diacylglycerol O-acyltransferase 2
DGAT2	Q96PD7	40	83	1	69	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGAT2	Q96PD7	40	83	70	88	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGAT2	Q96PD7	83	119	70	88	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGAT2	Q96PD7	83	119	89	92	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGAT2	Q96PD7	83	119	93	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGAT2	Q96PD7	83	119	113	388	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DGAT2	Q96PD7	40	83	41	83	Alternative sequence	ID=VSP_020356;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
DGAT2	Q96PD7	83	119	41	83	Alternative sequence	ID=VSP_020356;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
COBLL1	Q53SF7	446	485	1	1204	Chain	ID=PRO_0000260493;Note=Cordon-bleu protein-like 1
COBLL1	Q53SF7	291	370	1	1204	Chain	ID=PRO_0000260493;Note=Cordon-bleu protein-like 1
COBLL1	Q53SF7	52	114	1	1204	Chain	ID=PRO_0000260493;Note=Cordon-bleu protein-like 1
COBLL1	Q53SF7	291	370	329	334	Motif	Note=KKRRAP 1
COBLL1	Q53SF7	291	370	294	294	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:24275569
COBLL1	Q53SF7	291	370	298	298	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:24275569
COBLL1	Q53SF7	291	370	311	311	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
COBLL1	Q53SF7	291	370	322	322	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
COBLL1	Q53SF7	291	370	364	364	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UMF0
COBLL1	Q53SF7	446	485	145	1204	Alternative sequence	ID=VSP_021623;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COBLL1	Q53SF7	291	370	145	1204	Alternative sequence	ID=VSP_021623;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COBLL1	Q53SF7	446	485	447	486	Alternative sequence	ID=VSP_021624;Note=In isoform 2 and isoform 4. ETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTS->A;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.2;Dbxref=PMID:15489334,PMID:17974005
COBLL1	Q53SF7	291	370	368	368	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
COCH	O43405	11	27	1	24	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
COCH	O43405	11	27	25	550	Chain	ID=PRO_0000020968;Note=Cochlin
EBF1	Q9UH73	456	516	1	591	Chain	ID=PRO_0000107825;Note=Transcription factor COE1
EBF1	Q9UH73	162	184	1	591	Chain	ID=PRO_0000107825;Note=Transcription factor COE1
EBF1	Q9UH73	162	184	151	170	Zinc finger	Note=C5-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
EBF1	Q9UH73	456	516	462	550	Compositional bias	Note=Pro/Ser/Thr-rich
EBF1	Q9UH73	162	184	163	163	Site	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
EBF1	Q9UH73	162	184	172	172	Site	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
EBF1	Q9UH73	162	184	162	184	Alternative sequence	ID=VSP_012304;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EBF1	Q9UH73	162	184	162	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LYR
EBF1	Q9UH73	162	184	171	175	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LYR
EBF1	Q9UH73	162	184	181	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LYR
EBF1	Q9UH73	162	184	184	186	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LYR
COL15A1	P39059	216	241	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	451	501	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	549	567	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	567	587	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	693	740	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	825	837	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	837	858	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	983	1010	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	1177	1197	28	1388	Chain	ID=PRO_0000005788;Note=Collagen alpha-1(XV) chain
COL15A1	P39059	216	241	66	249	Domain	Note=Laminin G-like
COL15A1	P39059	451	501	409	459	Repeat	Note=2
COL15A1	P39059	451	501	460	509	Repeat	Note=3
COL15A1	P39059	549	567	510	555	Repeat	Note=4
COL15A1	P39059	693	740	681	731	Domain	Note=Collagen-like 2
COL15A1	P39059	825	837	823	865	Domain	Note=Collagen-like 3
COL15A1	P39059	837	858	823	865	Domain	Note=Collagen-like 3
COL15A1	P39059	216	241	229	555	Region	Note=Nonhelical region 1 (NC1)
COL15A1	P39059	451	501	229	555	Region	Note=Nonhelical region 1 (NC1)
COL15A1	P39059	549	567	229	555	Region	Note=Nonhelical region 1 (NC1)
COL15A1	P39059	451	501	358	555	Region	Note=4 X tandem repeats
COL15A1	P39059	549	567	358	555	Region	Note=4 X tandem repeats
COL15A1	P39059	549	567	556	573	Region	Note=Triple-helical region 1 (COL1)
COL15A1	P39059	567	587	556	573	Region	Note=Triple-helical region 1 (COL1)
COL15A1	P39059	567	587	574	618	Region	Note=Nonhelical region 2 (NC2)
COL15A1	P39059	693	740	619	732	Region	Note=Triple-helical region 2 (COL2)
COL15A1	P39059	693	740	733	763	Region	Note=Nonhelical region 3 (NC3)
COL15A1	P39059	825	837	823	867	Region	Note=Triple-helical region 4 (COL4)
COL15A1	P39059	837	858	823	867	Region	Note=Triple-helical region 4 (COL4)
COL15A1	P39059	983	1010	950	983	Region	Note=Nonhelical region 6 (NC6)
COL15A1	P39059	983	1010	984	1013	Region	Note=Triple-helical region 6 (COL6)
COL15A1	P39059	1177	1197	1133	1388	Region	Note=Nonhelical region 10 (NC10)
COL15A1	P39059	693	740	705	705	Natural variant	ID=VAR_061114;Note=P->L;Dbxref=dbSNP:rs41308900
COL15A1	P39059	983	1010	989	989	Natural variant	ID=VAR_033794;Note=K->R;Dbxref=dbSNP:rs35642150
COL15A1	P39059	983	1010	1001	1001	Natural variant	ID=VAR_033795;Note=K->R;Dbxref=dbSNP:rs35544077
COL15A1	P39059	1177	1197	1178	1197	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLPSL2	Q6UWE3	28	69	22	100	Chain	ID=PRO_0000022608;Note=Colipase-like protein 2
CLPSL2	Q6UWE3	28	69	34	45	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00674
CLPSL2	Q6UWE3	28	69	40	56	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00674
CLPSL2	Q6UWE3	28	69	44	78	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00674
CLPSL2	Q6UWE3	28	69	66	86	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00674
COMMD1	Q8N668	60	154	2	190	Chain	ID=PRO_0000077384;Note=COMM domain-containing protein 1
COMMD1	Q8N668	60	154	118	186	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD1	Q8N668	60	154	2	123	Region	Note=Sufficient for interaction with SLC12A2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23515529;Dbxref=PMID:23515529
COMMD1	Q8N668	60	154	125	190	Region	Note=Required for binding to PtdIns(4%2C5)P2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18940794;Dbxref=PMID:18940794
COMMD1	Q8N668	60	154	101	101	Metal binding	Note=Copper;Ontology_term=ECO:0000255;evidence=ECO:0000255
COMMD1	Q8N668	60	154	110	110	Metal binding	Note=Copper;Ontology_term=ECO:0000255;evidence=ECO:0000255
COMMD1	Q8N668	60	154	134	134	Metal binding	Note=Copper;Ontology_term=ECO:0000255;evidence=ECO:0000255
COMMD1	Q8N668	60	154	110	110	Mutagenesis	Note=Reduces copper-induced fluorescence change. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17309234;Dbxref=PMID:17309234
COMMD1	Q8N668	60	154	134	134	Mutagenesis	Note=Reduces copper-induced fluorescence change. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17309234;Dbxref=PMID:17309234
COMMD1	Q8N668	60	154	59	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	69	71	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	73	75	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	76	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	82	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	88	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	95	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
COMMD1	Q8N668	60	154	102	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H2M
DHCR24	Q15392	292	340	23	516	Chain	ID=PRO_0000007230;Note=Delta(24)-sterol reductase
DHCR24	Q15392	204	292	23	516	Chain	ID=PRO_0000007230;Note=Delta(24)-sterol reductase
DHCR24	Q15392	292	340	53	516	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DHCR24	Q15392	204	292	53	516	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DHCR24	Q15392	204	292	58	234	Domain	Note=FAD-binding PCMH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00718
DHCR24	Q15392	292	340	294	294	Natural variant	ID=VAR_012733;Note=In DESMOS. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11519011;Dbxref=dbSNP:rs281797257,PMID:11519011
DHCR24	Q15392	292	340	306	306	Natural variant	ID=VAR_012734;Note=In DESMOS. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11519011;Dbxref=dbSNP:rs281797256,PMID:11519011
COL23A1	Q86Y22	480	498	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	432	453	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	353	383	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	320	338	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	294	320	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	279	294	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	258	279	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	213	225	1	540	Chain	ID=PRO_0000245226;Note=Collagen alpha-1(XXIII) chain
COL23A1	Q86Y22	480	498	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	432	453	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	353	383	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	320	338	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	294	320	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	279	294	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	258	279	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	213	225	57	540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL23A1	Q86Y22	213	225	124	243	Domain	Note=Collagen-like 1
COL23A1	Q86Y22	294	320	251	305	Domain	Note=Collagen-like 2
COL23A1	Q86Y22	279	294	251	305	Domain	Note=Collagen-like 2
COL23A1	Q86Y22	258	279	251	305	Domain	Note=Collagen-like 2
COL23A1	Q86Y22	353	383	321	380	Domain	Note=Collagen-like 3
COL23A1	Q86Y22	320	338	321	380	Domain	Note=Collagen-like 3
COL23A1	Q86Y22	432	453	412	460	Domain	Note=Collagen-like 4
COL23A1	Q86Y22	480	498	463	522	Domain	Note=Collagen-like 5
COL23A1	Q86Y22	480	498	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	432	453	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	353	383	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	320	338	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	294	320	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	279	294	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	258	279	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	213	225	2	536	Compositional bias	Note=Gly-rich
COL23A1	Q86Y22	320	338	296	345	Alternative sequence	ID=VSP_019630;Note=In isoform 2. APGLKGEQGDTVVIDYDGRILDALKGPPGPQGPPGPPGIPGAKGELGLPG->DVRDPGLGSVSSCSQRLASSSKKNGSEPPPGCAGCPRPQGRAGRHSGDRL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL23A1	Q86Y22	294	320	296	345	Alternative sequence	ID=VSP_019630;Note=In isoform 2. APGLKGEQGDTVVIDYDGRILDALKGPPGPQGPPGPPGIPGAKGELGLPG->DVRDPGLGSVSSCSQRLASSSKKNGSEPPPGCAGCPRPQGRAGRHSGDRL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL23A1	Q86Y22	480	498	346	540	Alternative sequence	ID=VSP_019631;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL23A1	Q86Y22	432	453	346	540	Alternative sequence	ID=VSP_019631;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL23A1	Q86Y22	353	383	346	540	Alternative sequence	ID=VSP_019631;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL23A1	Q86Y22	279	294	287	287	Natural variant	ID=VAR_026964;Note=T->A;Dbxref=dbSNP:rs890802
COL24A1	Q17RW2	1594	1666	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	1446	1458	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	1389	1407	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	1317	1353	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	974	992	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	908	926	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	839	854	36	1714	Chain	ID=PRO_0000317616;Note=Collagen alpha-1(XXIV) chain
COL24A1	Q17RW2	839	854	798	857	Domain	Note=Collagen-like 5
COL24A1	Q17RW2	908	926	888	947	Domain	Note=Collagen-like 7
COL24A1	Q17RW2	974	992	948	1007	Domain	Note=Collagen-like 8
COL24A1	Q17RW2	1317	1353	1309	1353	Domain	Note=Collagen-like 15
COL24A1	Q17RW2	1389	1407	1354	1413	Domain	Note=Collagen-like 16
COL24A1	Q17RW2	1446	1458	1420	1479	Domain	Note=Collagen-like 17
COL24A1	Q17RW2	1594	1666	1515	1714	Domain	Note=Fibrillar collagen NC1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00793
COL24A1	Q17RW2	839	854	828	849	Sequence conflict	Note=GYAGEPGPEGLKGEVGDQGNIG->ITVFATLYSFLTGRSRRSRKYW;Ontology_term=ECO:0000305;evidence=ECO:0000305
COPB2	P35606	737	767	2	906	Chain	ID=PRO_0000050912;Note=Coatomer subunit beta'
COPB2	P35606	628	665	2	906	Chain	ID=PRO_0000050912;Note=Coatomer subunit beta'
COPZ1	P61923	6	29	1	177	Chain	ID=PRO_0000193825;Note=Coatomer subunit zeta-1
COPZ1	P61923	106	131	1	177	Chain	ID=PRO_0000193825;Note=Coatomer subunit zeta-1
COPZ1	P61923	149	162	1	177	Chain	ID=PRO_0000193825;Note=Coatomer subunit zeta-1
COPZ1	P61923	6	29	1	36	Alternative sequence	ID=VSP_053675;Note=In isoform 2. MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYP->MMEIDFLPSTMTTPTPVSRSKRPLRRTFSTRPIGLT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COPZ1	P61923	6	29	1	6	Alternative sequence	ID=VSP_055049;Note=In isoform 4. MEALIL->MGGFRTEGMFVSLQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
COPZ1	P61923	6	29	7	29	Alternative sequence	ID=VSP_055050;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COPZ1	P61923	149	162	147	163	Alternative sequence	ID=VSP_055051;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COPZ1	P61923	6	29	15	20	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MC7
COPZ1	P61923	6	29	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MC7
COPZ1	P61923	106	131	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MC7
COPZ1	P61923	106	131	111	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MC7
COPZ1	P61923	106	131	118	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MC7
COPZ1	P61923	149	162	139	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MC7
CORO2A	Q92828	255	290	1	525	Chain	ID=PRO_0000050928;Note=Coronin-2A
CORO2A	Q92828	255	290	1	525	Chain	ID=PRO_0000050928;Note=Coronin-2A
CORO2A	Q92828	255	290	215	259	Repeat	Note=WD 5
CORO2A	Q92828	255	290	215	259	Repeat	Note=WD 5
CORO2A	Q92828	255	290	260	305	Repeat	Note=WD 6
CORO2A	Q92828	255	290	260	305	Repeat	Note=WD 6
COQ9	O75208	202	237	45	318	Chain	ID=PRO_0000228637;Note=Ubiquinone biosynthesis protein COQ9%2C mitochondrial
COQ9	O75208	289	307	45	318	Chain	ID=PRO_0000228637;Note=Ubiquinone biosynthesis protein COQ9%2C mitochondrial
COQ9	O75208	202	237	136	318	Alternative sequence	ID=VSP_017684;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
COQ9	O75208	289	307	136	318	Alternative sequence	ID=VSP_017684;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16303743;Dbxref=PMID:16303743
COQ9	O75208	202	237	227	227	Mutagenesis	Note=Impairs interaction with COQ7. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25339443;Dbxref=PMID:25339443
COQ9	O75208	202	237	237	237	Mutagenesis	Note=Impairs interaction with COQ7. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25339443;Dbxref=PMID:25339443
COQ9	O75208	202	237	200	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RHP
COQ9	O75208	202	237	210	212	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RHP
COQ9	O75208	202	237	213	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RHP
COQ9	O75208	289	307	294	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RHP
SORD	Q00796	33	88	2	357	Chain	ID=PRO_0000160817;Note=Sorbitol dehydrogenase
SORD	Q00796	33	88	45	45	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12962626;Dbxref=PMID:12962626
SORD	Q00796	33	88	70	70	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12962626;Dbxref=PMID:12962626
SORD	Q00796	33	88	71	71	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12962626;Dbxref=PMID:12962626
SORD	Q00796	33	88	51	51	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07846
SORD	Q00796	33	88	59	59	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
SORD	Q00796	33	88	34	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PL8
SORD	Q00796	33	88	46	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PL8
SORD	Q00796	33	88	55	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PL8
SORD	Q00796	33	88	71	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1PL8
DHTKD1	Q96HY7	174	239	183	183	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2ATU0
DHTKD1	Q96HY7	174	239	188	188	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2ATU0
DHTKD1	Q96HY7	239	329	272	272	Natural variant	ID=VAR_036716;Note=Y->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3740015,PMID:10997877,PMID:15489334
DHTKD1	Q96HY7	239	329	308	308	Natural variant	ID=VAR_036717;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17849603,PMID:15489334
DHTKD1	Q96HY7	718	773	729	729	Natural variant	ID=VAR_069585;Note=In AMOXAD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23141293;Dbxref=dbSNP:rs117225135,PMID:23141293
DHX29	Q7Z478	1276	1320	1	1369	Chain	ID=PRO_0000245535;Note=ATP-dependent RNA helicase DHX29
DHX29	Q7Z478	1175	1276	1	1369	Chain	ID=PRO_0000245535;Note=ATP-dependent RNA helicase DHX29
COX5A	P20674	33	72	1	41	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:8313870;Dbxref=PMID:25944712,PMID:8313870
COX5A	P20674	33	72	42	150	Chain	ID=PRO_0000006100;Note=Cytochrome c oxidase subunit 5A%2C mitochondrial
CMC2	Q9NRP2	27	51	1	79	Chain	ID=PRO_0000192943;Note=COX assembly mitochondrial protein 2 homolog
CMC2	Q9NRP2	27	51	1	79	Chain	ID=PRO_0000192943;Note=COX assembly mitochondrial protein 2 homolog
CMC2	Q9NRP2	27	51	1	79	Chain	ID=PRO_0000192943;Note=COX assembly mitochondrial protein 2 homolog
CMC2	Q9NRP2	27	51	11	55	Domain	Note=CHCH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	11	55	Domain	Note=CHCH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	11	55	Domain	Note=CHCH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	37	47	Motif	Note=Cx9C motif 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	37	47	Motif	Note=Cx9C motif 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	37	47	Motif	Note=Cx9C motif 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	14	47	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	14	47	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	14	47	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	24	37	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	24	37	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CMC2	Q9NRP2	27	51	24	37	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CUX2	O14529	58	74	1	1486	Chain	ID=PRO_0000202396;Note=Homeobox protein cut-like 2
CUX2	O14529	100	145	1	1486	Chain	ID=PRO_0000202396;Note=Homeobox protein cut-like 2
CUX2	O14529	251	286	1	1486	Chain	ID=PRO_0000202396;Note=Homeobox protein cut-like 2
CUX2	O14529	975	1065	1	1486	Chain	ID=PRO_0000202396;Note=Homeobox protein cut-like 2
CUX2	O14529	975	1065	1038	1125	DNA binding	Note=CUT 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00374
CUX2	O14529	251	286	195	374	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CUX2	O14529	100	145	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CUX2	O14529	975	1065	1037	1043	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WH8
CUX2	O14529	975	1065	1049	1062	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WH8
BEGAIN	Q9BUH8	117	145	1	593	Chain	ID=PRO_0000064904;Note=Brain-enriched guanylate kinase-associated protein
BEGAIN	Q9BUH8	117	145	1	593	Chain	ID=PRO_0000064904;Note=Brain-enriched guanylate kinase-associated protein
BEGAIN	Q9BUH8	117	145	137	137	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68EF6
BEGAIN	Q9BUH8	117	145	137	137	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68EF6
BEST2	Q8NFU1	212	238	1	509	Chain	ID=PRO_0000143118;Note=Bestrophin-2
BEST2	Q8NFU1	212	238	1	509	Chain	ID=PRO_0000143118;Note=Bestrophin-2
BEST2	Q8NFU1	212	238	1	509	Chain	ID=PRO_0000143118;Note=Bestrophin-2
BEST2	Q8NFU1	212	238	200	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST2	Q8NFU1	212	238	200	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST2	Q8NFU1	212	238	200	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST2	Q8NFU1	212	238	229	249	Intramembrane	Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST2	Q8NFU1	212	238	229	249	Intramembrane	Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST2	Q8NFU1	212	238	229	249	Intramembrane	Ontology_term=ECO:0000255;evidence=ECO:0000255
BET1L	Q9NYM9	37	56	1	111	Chain	ID=PRO_0000233056;Note=BET1-like protein
BET1L	Q9NYM9	37	56	1	86	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BET1L	Q9NYM9	37	56	15	77	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
BET1L	Q9NYM9	37	56	37	37	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BET1	O15155	48	67	1	118	Chain	ID=PRO_0000206884;Note=BET1 homolog
BET1	O15155	48	67	1	94	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BET1	O15155	48	67	26	88	Domain	Note=t-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00202
BET1	O15155	48	67	50	50	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
CLN6	Q9NWW5	99	162	1	311	Chain	ID=PRO_0000089862;Note=Ceroid-lipofuscinosis neuronal protein 6
CLN6	Q9NWW5	99	162	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLN6	Q9NWW5	99	162	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLN6	Q9NWW5	99	162	103	103	Natural variant	ID=VAR_065839;Note=In CLN4A. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549341;Dbxref=dbSNP:rs154774634,PMID:21549341
CLN6	Q9NWW5	99	162	104	104	Natural variant	ID=VAR_066907;Note=In CLN6. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990111;Dbxref=PMID:21990111
CLN6	Q9NWW5	99	162	123	123	Natural variant	ID=VAR_015683;Note=In CLN6. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11727201;Dbxref=dbSNP:rs104894484,PMID:11727201
CLN6	Q9NWW5	99	162	149	149	Natural variant	ID=VAR_066908;Note=In CLN6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21990111;Dbxref=dbSNP:rs747229909,PMID:21990111
CLN6	Q9NWW5	99	162	149	149	Natural variant	ID=VAR_065840;Note=In CLN4A. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549341;Dbxref=dbSNP:rs154774638,PMID:21549341
CLN6	Q9NWW5	99	162	154	154	Natural variant	ID=VAR_015684;Note=In CLN6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11727201;Dbxref=PMID:11727201
CLN6	Q9NWW5	99	162	159	159	Natural variant	ID=VAR_058436;Note=In CLN6. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19201763;Dbxref=dbSNP:rs919850756,PMID:19201763
CLIC2	O15247	56	97	1	247	Chain	ID=PRO_0000144205;Note=Chloride intracellular channel protein 2
CLIC2	O15247	56	97	1	96	Region	Note=Required for insertion into the membrane;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLIC2	O15247	56	97	1	94	Region	Note=N-terminal
CLIC2	O15247	56	97	95	106	Region	Note=Joint loop
CLIC2	O15247	56	97	57	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R5G
CLIC2	O15247	56	97	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4V
CLIC2	O15247	56	97	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4V
CLIC2	O15247	56	97	78	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4V
CLIC2	O15247	56	97	83	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4V
CLIC2	O15247	56	97	96	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R4V
CLPTM1	O96005	103	156	2	669	Chain	ID=PRO_0000245096;Note=Cleft lip and palate transmembrane protein 1
CLPTM1	O96005	441	473	2	669	Chain	ID=PRO_0000245096;Note=Cleft lip and palate transmembrane protein 1
CLPTM1	O96005	103	156	2	354	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLPTM1	O96005	441	473	438	477	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLPTM1	O96005	103	156	119	119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLPTM1	O96005	103	156	103	103	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC25A13	Q9UJS0	437	484	2	675	Chain	ID=PRO_0000090600;Note=Calcium-binding mitochondrial carrier protein Aralar2
SLC25A13	Q9UJS0	437	484	436	449	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O75746
SLC25A13	Q9UJS0	437	484	426	510	Repeat	Note=Solcar 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00282
SLC25A13	Q9UJS0	437	484	321	612	Region	Note=Carrier domain;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:25410934;Dbxref=PMID:25410934
SLC25A13	Q9UJS0	437	484	453	453	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
SLC25A13	Q9UJS0	437	484	484	484	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXX4
SLC25A13	Q9UJS0	437	484	484	484	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXX4
CAMKMT	Q7Z624	208	232	1	323	Chain	ID=PRO_0000300115;Note=Calmodulin-lysine N-methyltransferase
CAMKMT	Q7Z624	254	298	1	323	Chain	ID=PRO_0000300115;Note=Calmodulin-lysine N-methyltransferase
CAMKMT	Q7Z624	208	232	133	323	Alternative sequence	ID=VSP_027785;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAMKMT	Q7Z624	254	298	133	323	Alternative sequence	ID=VSP_027785;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAMKMT	Q7Z624	208	232	209	209	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAMKMT	Q7Z624	208	232	205	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	208	232	215	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	208	232	220	223	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	208	232	225	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	254	298	251	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	254	298	264	266	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	254	298	267	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	254	298	280	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CAMKMT	Q7Z624	254	298	290	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PWY
CNNM1	Q9NRU3	709	725	1	951	Chain	ID=PRO_0000295758;Note=Metal transporter CNNM1
CNNM1	Q9NRU3	841	891	1	951	Chain	ID=PRO_0000295758;Note=Metal transporter CNNM1
CNNM1	Q9NRU3	841	891	850	850	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q0GA42
CNNM1	Q9NRU3	841	891	842	892	Alternative sequence	ID=VSP_027076;Note=In isoform 2. CSRSDGLRSPSEVVYLRMEELAFTQEEMTDFEEHSTQQLTLSPAAVPTRAA->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C14orf28	Q4W4Y0	175	204	1	310	Chain	ID=PRO_0000274307;Note=Uncharacterized protein C14orf28
CNDP2	Q96KP4	152	219	2	475	Chain	ID=PRO_0000185272;Note=Cytosolic non-specific dipeptidase
CNDP2	Q96KP4	301	356	2	475	Chain	ID=PRO_0000185272;Note=Cytosolic non-specific dipeptidase
CNDP2	Q96KP4	152	219	2	475	Chain	ID=PRO_0000185272;Note=Cytosolic non-specific dipeptidase
CNDP2	Q96KP4	301	356	2	475	Chain	ID=PRO_0000185272;Note=Cytosolic non-specific dipeptidase
CNDP2	Q96KP4	152	219	166	167	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	166	167	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	166	166	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	166	166	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	167	167	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	167	167	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	195	195	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	195	195	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	195	195	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	195	195	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	301	356	330	330	Binding site	Note=Substrate%3B shared with homodimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	301	356	330	330	Binding site	Note=Substrate%3B shared with homodimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	301	356	343	343	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	301	356	343	343	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNDP2	Q96KP4	152	219	69	152	Alternative sequence	ID=VSP_038203;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
CNDP2	Q96KP4	152	219	69	152	Alternative sequence	ID=VSP_038203;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
CNDP2	Q96KP4	301	356	348	348	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNDP2	Q96KP4	301	356	348	348	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNDP2	Q96KP4	152	219	155	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	155	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	173	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	173	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	181	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	181	184	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	190	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	199	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	199	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	205	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	205	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	212	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	152	219	212	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	301	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	301	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	313	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	313	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	325	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	325	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	334	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	334	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	350	368	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
CNDP2	Q96KP4	301	356	350	368	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RUH
C7	P10643	189	246	23	843	Chain	ID=PRO_0000023583;Note=Complement component C7
C7	P10643	189	246	124	456	Domain	Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745
C7	P10643	189	246	202	202	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952
C7	P10643	189	246	220	220	Natural variant	ID=VAR_012643;Note=In C7D. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9856499;Dbxref=dbSNP:rs369349760,PMID:9856499
COL9A3	Q14050	49	61	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	61	85	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	173	192	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	192	210	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	228	246	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	429	441	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	467	516	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	534	595	26	684	Chain	ID=PRO_0000005848;Note=Collagen alpha-3(IX) chain
COL9A3	Q14050	49	61	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	61	85	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	173	192	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	192	210	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	228	246	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	429	441	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	467	516	29	519	Region	Note=Triple-helical region 3 (COL3)
COL9A3	Q14050	534	595	520	550	Region	Note=Nonhelical region 3 (NC3)
COL9A3	Q14050	534	595	551	630	Region	Note=Triple-helical region 2 (COL2)
COL9A3	Q14050	467	516	483	483	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL9A3	Q14050	429	441	435	435	Natural variant	ID=VAR_026471;Note=A->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11565064,ECO:0000269|PubMed:8586434;Dbxref=dbSNP:rs751557,PMID:11565064,PMID:8586434
COL9A3	Q14050	534	595	563	565	Natural variant	ID=VAR_012660;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10428822;Dbxref=PMID:10428822
COL9A3	Q14050	534	595	564	566	Natural variant	ID=VAR_012661;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10428822;Dbxref=PMID:10428822
COL9A3	Q14050	534	595	576	576	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL9A3	Q14050	534	595	522	543	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CTD
DAGLA	Q9Y4D2	376	404	1	1042	Chain	ID=PRO_0000248347;Note=Sn1-specific diacylglycerol lipase alpha
DAGLA	Q9Y4D2	376	404	158	1042	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COLEC12	Q5KU26	442	605	1	742	Chain	ID=PRO_0000318681;Note=Collectin-12
COLEC12	Q5KU26	60	93	1	742	Chain	ID=PRO_0000318681;Note=Collectin-12
COLEC12	Q5KU26	442	605	59	742	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COLEC12	Q5KU26	60	93	59	742	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COLEC12	Q5KU26	442	605	443	472	Domain	Note=Collagen-like 1
COLEC12	Q5KU26	442	605	473	529	Domain	Note=Collagen-like 2
COLEC12	Q5KU26	442	605	530	589	Domain	Note=Collagen-like 3
COLEC12	Q5KU26	60	93	73	141	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
COLEC12	Q5KU26	60	93	67	67	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COLEC12	Q5KU26	60	93	91	91	Natural variant	ID=VAR_038853;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855029,PMID:15489334
COLEC12	Q5KU26	442	605	487	487	Natural variant	ID=VAR_038854;Note=I->V;Dbxref=dbSNP:rs8098850
COLEC12	Q5KU26	442	605	522	522	Natural variant	ID=VAR_038855;Note=S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11162630,ECO:0000269|PubMed:11564734,ECO:0000269|PubMed:12601552,ECO:0000269|PubMed:12761161,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2305025,PMID:11162630,PMID:11564734,PMID:12601552,PMID:12761161,PMID:15489334
COLEC12	Q5KU26	60	93	72	72	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL17A1	Q9UMD9	1452	1479	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	1169	1206	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	1139	1169	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	1092	1139	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	1023	1069	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	965	982	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	929	940	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	900	920	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	882	900	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	799	811	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	787	799	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	742	754	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	611	646	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	590	611	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	407	422	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	303	326	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	279	303	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	202	255	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	110	126	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	67	110	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	32	67	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	17	32	1	1497	Chain	ID=PRO_0000059406;Note=Collagen alpha-1(XVII) chain
COL17A1	Q9UMD9	1452	1479	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	1169	1206	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	1139	1169	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	1092	1139	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	1023	1069	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	965	982	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	929	940	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	900	920	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	882	900	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	799	811	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	787	799	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	742	754	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	611	646	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	590	611	524	1497	Chain	ID=PRO_0000342555;Note=120 kDa linear IgA disease antigen
COL17A1	Q9UMD9	407	422	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	303	326	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	279	303	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	202	255	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	110	126	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	67	110	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	32	67	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	17	32	1	467	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	1452	1479	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	1169	1206	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	1139	1169	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	1092	1139	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	1023	1069	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	965	982	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	929	940	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	900	920	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	882	900	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	799	811	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	787	799	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	742	754	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	611	646	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	590	611	489	1497	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL17A1	Q9UMD9	407	422	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	303	326	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	279	303	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	202	255	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	110	126	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	67	110	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	32	67	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	17	32	1	566	Region	Note=Nonhelical region (NC16)
COL17A1	Q9UMD9	202	255	145	230	Region	Note=Necessary for interaction with DST and for the recruitment of DST to hemidesmosome;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12482924;Dbxref=PMID:12482924
COL17A1	Q9UMD9	1452	1479	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	1169	1206	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	1139	1169	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	1092	1139	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	1023	1069	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	965	982	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	929	940	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	900	920	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	882	900	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	799	811	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	787	799	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	742	754	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	611	646	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	590	611	567	1482	Region	Note=Triple-helical region
COL17A1	Q9UMD9	965	982	922	966	Alternative sequence	ID=VSP_024940;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL17A1	Q9UMD9	929	940	922	966	Alternative sequence	ID=VSP_024940;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL17A1	Q9UMD9	1169	1206	1170	1207	Alternative sequence	ID=VSP_024941;Note=In isoform 2. GSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSYLHT->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL17A1	Q9UMD9	202	255	210	210	Natural variant	ID=VAR_017593;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs805708,PMID:15489334
COL17A1	Q9UMD9	202	255	231	231	Natural variant	ID=VAR_017594;Note=M->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11912005,ECO:0000269|PubMed:9012408;Dbxref=dbSNP:rs1054113,PMID:11912005,PMID:9012408
COL17A1	Q9UMD9	202	255	238	238	Natural variant	ID=VAR_017595;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9012408;Dbxref=PMID:9012408
COL17A1	Q9UMD9	611	646	627	627	Natural variant	ID=VAR_017598;Note=In GABEB. G->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10652291,ECO:0000269|PubMed:8669466;Dbxref=PMID:10652291,PMID:8669466
COL17A1	Q9UMD9	611	646	633	633	Natural variant	ID=VAR_017599;Note=In GABEB. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10951237;Dbxref=dbSNP:rs121912773,PMID:10951237
COL17A1	Q9UMD9	929	940	939	939	Natural variant	ID=VAR_074627;Note=In ERED. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25676728;Dbxref=dbSNP:rs797045142,PMID:25676728
COL17A1	Q9UMD9	900	920	905	905	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL17A1	Q9UMD9	900	920	905	905	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CMIP	Q8IY22	142	159	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	227	248	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	248	275	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	310	344	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	345	462	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	463	484	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	510	546	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	546	585	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	632	648	1	773	Chain	ID=PRO_0000317628;Note=C-Maf-inducing protein
CMIP	Q8IY22	142	159	54	163	Domain	Note=PH
CMIP	Q8IY22	345	462	349	349	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CMIP	Q8IY22	345	462	377	377	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:23186163;Dbxref=PMID:18220336,PMID:23186163
CMIP	Q8IY22	345	462	382	382	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CMIP	Q8IY22	142	159	1	153	Alternative sequence	ID=VSP_031108;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CMIP	Q8IY22	142	159	154	159	Alternative sequence	ID=VSP_031111;Note=In isoform 3. HSLQWK->MASVAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CMSS1	Q9BQ75	51	75	1	279	Chain	ID=PRO_0000239014;Note=Protein CMSS1
CMSS1	Q9BQ75	118	138	1	279	Chain	ID=PRO_0000239014;Note=Protein CMSS1
CMSS1	Q9BQ75	118	138	138	138	Natural variant	ID=VAR_047645;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11537817,PMID:15489334
CMSS1	Q9BQ75	51	75	75	75	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNN3	Q15417	82	128	1	329	Chain	ID=PRO_0000204776;Note=Calponin-3
CNN3	Q15417	82	128	26	130	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CNN3	Q15417	82	128	83	128	Alternative sequence	ID=VSP_055192;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	1	292	Chain	ID=PRO_0000212846;Note=CCR4-NOT transcription complex subunit 8
CNOT8	Q9UFF9	104	157	1	292	Chain	ID=PRO_0000212846;Note=CCR4-NOT transcription complex subunit 8
CNOT8	Q9UFF9	104	157	1	292	Chain	ID=PRO_0000212846;Note=CCR4-NOT transcription complex subunit 8
CNOT8	Q9UFF9	104	157	1	106	Alternative sequence	ID=VSP_055527;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	1	106	Alternative sequence	ID=VSP_055527;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	1	106	Alternative sequence	ID=VSP_055527;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	105	158	Alternative sequence	ID=VSP_055528;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	105	158	Alternative sequence	ID=VSP_055528;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	105	158	Alternative sequence	ID=VSP_055528;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNOT8	Q9UFF9	104	157	99	105	Sequence conflict	Note=FKFNLTE->CKLYLTV;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT8	Q9UFF9	104	157	99	105	Sequence conflict	Note=FKFNLTE->CKLYLTV;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT8	Q9UFF9	104	157	99	105	Sequence conflict	Note=FKFNLTE->CKLYLTV;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT8	Q9UFF9	104	157	152	152	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT8	Q9UFF9	104	157	152	152	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT8	Q9UFF9	104	157	152	152	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNTD2	Q9H8S5	119	171	1	307	Chain	ID=PRO_0000263704;Note=Cyclin N-terminal domain-containing protein 2
CNTD2	Q9H8S5	89	119	1	307	Chain	ID=PRO_0000263704;Note=Cyclin N-terminal domain-containing protein 2
CNTD2	Q9H8S5	119	171	102	203	Domain	Note=Cyclin N-terminal
CNTD2	Q9H8S5	89	119	102	203	Domain	Note=Cyclin N-terminal
CNTD2	Q9H8S5	119	171	90	119	Alternative sequence	ID=VSP_044165;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNTD2	Q9H8S5	89	119	90	119	Alternative sequence	ID=VSP_044165;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
COL7A1	Q02388	2842	2873	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2661	2682	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2562	2586	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2495	2507	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2460	2480	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2388	2424	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2356	2368	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2341	2356	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2300	2312	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2277	2300	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2206	2217	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2191	2206	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	2116	2131	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1940	1952	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1900	1912	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1868	1900	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1844	1856	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1408	1426	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1373	1399	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1325	1337	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	1241	1253	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	813	862	17	2944	Chain	ID=PRO_0000005761;Note=Collagen alpha-1(VII) chain
COL7A1	Q02388	813	862	778	866	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL7A1	Q02388	2842	2873	2872	2944	Domain	Note=BPTI/Kunitz inhibitor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
COL7A1	Q02388	1241	1253	17	1253	Region	Note=Nonhelical region (NC1)
COL7A1	Q02388	813	862	17	1253	Region	Note=Nonhelical region (NC1)
COL7A1	Q02388	2661	2682	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2562	2586	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2495	2507	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2460	2480	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2388	2424	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2356	2368	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2341	2356	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2300	2312	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2277	2300	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2206	2217	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2191	2206	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	2116	2131	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1940	1952	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1900	1912	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1868	1900	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1844	1856	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1408	1426	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1373	1399	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1325	1337	1254	2784	Region	Note=Triple-helical region
COL7A1	Q02388	1408	1426	1254	1477	Region	Note=Interrupted collagenous region
COL7A1	Q02388	1373	1399	1254	1477	Region	Note=Interrupted collagenous region
COL7A1	Q02388	1325	1337	1254	1477	Region	Note=Interrupted collagenous region
COL7A1	Q02388	2842	2873	2785	2944	Region	Note=Nonhelical region (NC2)
COL7A1	Q02388	1325	1337	1334	1336	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL7A1	Q02388	2661	2682	2664	2664	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8051117;Dbxref=PMID:8051117
COL7A1	Q02388	2661	2682	2667	2667	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8051117;Dbxref=PMID:8051117
COL7A1	Q02388	2661	2682	2673	2673	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8051117;Dbxref=PMID:8051117
COL7A1	Q02388	1900	1912	1869	1900	Alternative sequence	ID=VSP_024026;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL7A1	Q02388	1868	1900	1869	1900	Alternative sequence	ID=VSP_024026;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL7A1	Q02388	1844	1856	1845	1845	Natural variant	ID=VAR_064994;Note=In RDEB. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20598510;Dbxref=PMID:20598510
COL7A1	Q02388	2191	2206	2192	2192	Natural variant	ID=VAR_011187;Note=In RDEB. G->S
COL7A1	Q02388	2206	2217	2207	2207	Natural variant	ID=VAR_011188;Note=In DDEB. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9740253;Dbxref=PMID:9740253
COL7A1	Q02388	2277	2300	2287	2287	Natural variant	ID=VAR_011191;Note=In RDEB%3B moderately severe phenotype when compound heterozygous with R-2316%3B leads to isolated toenail dystrophy when heterozygous with a normal allele. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10469344;Dbxref=dbSNP:rs121912839,PMID:10469344
COL7A1	Q02388	2277	2300	2296	2296	Natural variant	ID=VAR_064999;Note=In RDEB. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20598510;Dbxref=PMID:20598510
COL7A1	Q02388	2341	2356	2348	2348	Natural variant	ID=VAR_011193;Note=In DDEB/RDEB%3B mild form. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10232407;Dbxref=PMID:10232407
COL7A1	Q02388	2341	2356	2351	2351	Natural variant	ID=VAR_001829;Note=In a patient with dystrophic epidermolysis bullosa%3B mitis type. G->R;Dbxref=dbSNP:rs1800013
COL7A1	Q02388	2356	2368	2366	2366	Natural variant	ID=VAR_011194;Note=In RDEB%3B mitis type. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10232406;Dbxref=PMID:10232406
COL7A1	Q02388	2562	2586	2569	2569	Natural variant	ID=VAR_001830;Note=In RDEB%3B severe and mitis type. G->R
COL7A1	Q02388	2562	2586	2575	2575	Natural variant	ID=VAR_001831;Note=In RDEB. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8592061,ECO:0000269|PubMed:9326325;Dbxref=dbSNP:rs760891216,PMID:8592061,PMID:9326325
COL7A1	Q02388	2661	2682	2671	2671	Natural variant	ID=VAR_001834;Note=In RDEB. G->V
COL7A1	Q02388	2661	2682	2674	2674	Natural variant	ID=VAR_011196;Note=In RDEB. G->D
COL7A1	Q02388	2661	2682	2674	2674	Natural variant	ID=VAR_001835;Note=In RDEB%3B mitis type. G->R
COL7A1	Q02388	813	862	851	851	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL4A2	P08572	33	60	26	183	Propeptide	ID=PRO_0000005824;Note=N-terminal propeptide (7S domain)
COL4A2	P08572	60	105	26	183	Propeptide	ID=PRO_0000005824;Note=N-terminal propeptide (7S domain)
COL4A2	P08572	287	304	184	1712	Chain	ID=PRO_0000005825;Note=Collagen alpha-2(IV) chain
COL4A2	P08572	734	808	184	1712	Chain	ID=PRO_0000005825;Note=Collagen alpha-2(IV) chain
COL4A2	P08572	1151	1187	184	1712	Chain	ID=PRO_0000005825;Note=Collagen alpha-2(IV) chain
COL4A2	P08572	1187	1211	184	1712	Chain	ID=PRO_0000005825;Note=Collagen alpha-2(IV) chain
COL4A2	P08572	287	304	184	1484	Region	Note=Triple-helical region
COL4A2	P08572	734	808	184	1484	Region	Note=Triple-helical region
COL4A2	P08572	1151	1187	184	1484	Region	Note=Triple-helical region
COL4A2	P08572	1187	1211	184	1484	Region	Note=Triple-helical region
COL4A2	P08572	1151	1187	1152	1152	Natural variant	ID=VAR_067838;Note=In POREN2%3B incomplete penetrance. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22209246;Dbxref=dbSNP:rs387906602,PMID:22209246
CNOT7	Q9UIV1	206	243	1	285	Chain	ID=PRO_0000212844;Note=CCR4-NOT transcription complex subunit 7
CNOT7	Q9UIV1	104	157	1	285	Chain	ID=PRO_0000212844;Note=CCR4-NOT transcription complex subunit 7
CNOT7	Q9UIV1	206	243	230	230	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT7	Q9UIV1	104	157	138	138	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with Y-142 and K-149. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	104	157	141	141	Mutagenesis	Note=Abolishes interaction with CNOT1. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	104	157	142	142	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with K-138 and K-149. T->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	104	157	149	149	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with K-138 and Y-142. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	206	243	225	225	Mutagenesis	Note=Abolishes RNA deadenylase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19276069;Dbxref=PMID:19276069
CNOT7	Q9UIV1	206	243	230	230	Mutagenesis	Note=Abolishes RNA deadenylase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19276069;Dbxref=PMID:19276069
CNOT7	Q9UIV1	206	243	241	241	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT7	Q9UIV1	104	157	103	105	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	110	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	123	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	133	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	142	144	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	145	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	152	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	206	243	209	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	206	243	227	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
EBF3	Q9H4W6	457	520	1	596	Chain	ID=PRO_0000107832;Note=Transcription factor COE3
EBF3	Q9H4W6	162	184	1	596	Chain	ID=PRO_0000107832;Note=Transcription factor COE3
EBF3	Q9H4W6	162	184	151	170	Zinc finger	Note=C5-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
EBF3	Q9H4W6	457	520	464	555	Compositional bias	Note=Pro/Ser/Thr-rich
EBF3	Q9H4W6	162	184	163	163	Site	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
EBF3	Q9H4W6	162	184	172	172	Site	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
EBF3	Q9H4W6	162	184	163	163	Natural variant	ID=VAR_078036;Note=In HADDS%3B partial loss of transcriptional activator activity. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28017372;Dbxref=dbSNP:rs1057519389,PMID:28017372
EBF3	Q9H4W6	162	184	163	163	Natural variant	ID=VAR_078037;Note=In HADDS%3B loss of transcriptional activator activity. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28017370;Dbxref=dbSNP:rs1057519389,PMID:28017370
EBF3	Q9H4W6	162	184	163	163	Natural variant	ID=VAR_078038;Note=In HADDS%3B loss of transcriptional activator activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28017372;Dbxref=dbSNP:rs1057519389,PMID:28017372
EBF3	Q9H4W6	162	184	171	171	Natural variant	ID=VAR_078039;Note=In HADDS%3B significant loss of transcriptional activator activity%3B localizes both in the cytoplasm and the nucleus%3B decreased chromatin-binding. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28017373;Dbxref=dbSNP:rs1057519437,PMID:28017373
EBF3	Q9H4W6	162	184	177	177	Natural variant	ID=VAR_078040;Note=In HADDS%3B according to PubMed:28017373 shows significant loss of transcriptional activator activity while according to PubMed:28017370 shows partial loss of transcriptional activator activity%3B localizes both in the cytoplasm and the nucleus%3B decreased chromatin-binding. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28017370,ECO:0000269|PubMed:28017373;Dbxref=dbSNP:rs869312668,PMID:28017370,PMID:28017373
COL20A1	Q9P218	165	218	23	1284	Chain	ID=PRO_0000013986;Note=Collagen alpha-1(XX) chain
COL20A1	Q9P218	1080	1098	23	1284	Chain	ID=PRO_0000013986;Note=Collagen alpha-1(XX) chain
COL20A1	Q9P218	1116	1134	23	1284	Chain	ID=PRO_0000013986;Note=Collagen alpha-1(XX) chain
COL20A1	Q9P218	1152	1176	23	1284	Chain	ID=PRO_0000013986;Note=Collagen alpha-1(XX) chain
COL20A1	Q9P218	165	218	179	354	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
COL20A1	Q9P218	1080	1098	1071	1127	Domain	Note=Collagen-like 1
COL20A1	Q9P218	1116	1134	1071	1127	Domain	Note=Collagen-like 1
COL20A1	Q9P218	1116	1134	1133	1190	Domain	Note=Collagen-like 2
COL20A1	Q9P218	1152	1176	1133	1190	Domain	Note=Collagen-like 2
COL20A1	Q9P218	165	218	165	166	Alternative sequence	ID=VSP_038876;Note=In isoform 2. PA->PGGSEWRET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
COL20A1	Q9P218	1080	1098	1098	1098	Alternative sequence	ID=VSP_038877;Note=In isoform 3. R->RGEPGPPGQMGPEGPGGQQGSPGTQGRAVQGPV;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
COMMD6	Q7Z4G1	18	69	1	85	Chain	ID=PRO_0000077398;Note=COMM domain-containing protein 6
COMMD6	Q7Z4G1	18	69	1	85	Chain	ID=PRO_0000077398;Note=COMM domain-containing protein 6
COMMD6	Q7Z4G1	18	69	18	85	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD6	Q7Z4G1	18	69	18	85	Domain	Note=COMM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00602
COMMD6	Q7Z4G1	18	69	69	69	Alternative sequence	ID=VSP_026593;Note=In isoform 2. Q->QPQLLATSSLLSAS;Ontology_term=ECO:0000305;evidence=ECO:0000305
COMMD6	Q7Z4G1	18	69	69	69	Alternative sequence	ID=VSP_026593;Note=In isoform 2. Q->QPQLLATSSLLSAS;Ontology_term=ECO:0000305;evidence=ECO:0000305
COMMD6	Q7Z4G1	18	69	52	52	Natural variant	ID=VAR_048813;Note=H->N;Dbxref=dbSNP:rs1063485
COMMD6	Q7Z4G1	18	69	52	52	Natural variant	ID=VAR_048813;Note=H->N;Dbxref=dbSNP:rs1063485
COMMD6	Q7Z4G1	18	69	24	24	Mutagenesis	Note=Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation%3B when associated with A-41. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16573520;Dbxref=PMID:16573520
COMMD6	Q7Z4G1	18	69	24	24	Mutagenesis	Note=Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation%3B when associated with A-41. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16573520;Dbxref=PMID:16573520
COMMD6	Q7Z4G1	18	69	41	41	Mutagenesis	Note=Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation%3B when associated with A-24. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16573520;Dbxref=PMID:16573520
COMMD6	Q7Z4G1	18	69	41	41	Mutagenesis	Note=Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation%3B when associated with A-24. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16573520;Dbxref=PMID:16573520
GLUD1	P00367	498	519	54	558	Chain	ID=PRO_0000007206;Note=Glutamate dehydrogenase 1%2C mitochondrial
GLUD1	P00367	353	399	54	558	Chain	ID=PRO_0000007206;Note=Glutamate dehydrogenase 1%2C mitochondrial
GLUD1	P00367	307	353	54	558	Chain	ID=PRO_0000007206;Note=Glutamate dehydrogenase 1%2C mitochondrial
GLUD1	P00367	247	307	54	558	Chain	ID=PRO_0000007206;Note=Glutamate dehydrogenase 1%2C mitochondrial
GLUD1	P00367	247	307	252	252	Binding site	Note=NAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	247	307	266	266	Binding site	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	247	307	270	270	Binding site	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	307	353	319	319	Binding site	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	307	353	322	322	Binding site	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	498	519	516	516	Binding site	Note=ADP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	307	353	326	326	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	307	353	346	346	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	307	353	346	346	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	307	353	352	352	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	307	353	352	352	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	353	399	363	363	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00366
GLUD1	P00367	353	399	363	363	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00366
GLUD1	P00367	353	399	365	365	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00366
GLUD1	P00367	353	399	365	365	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	353	399	384	384	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GLUD1	P00367	353	399	386	386	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00366
GLUD1	P00367	353	399	390	390	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	353	399	390	390	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26443
GLUD1	P00367	353	399	399	399	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00366
GLUD1	P00367	498	519	503	503	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
GLUD1	P00367	498	519	503	503	Modified residue	Note=N6-malonyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250
GLUD1	P00367	498	519	503	503	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00366
GLUD1	P00367	498	519	512	512	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
GLUD1	P00367	247	307	270	270	Natural variant	ID=VAR_016760;Note=In HHF6%3B diminished sensitivity to GTP. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11297618;Dbxref=PMID:11297618
GLUD1	P00367	247	307	274	274	Natural variant	ID=VAR_016761;Note=In HHF6%3B diminished sensitivity to GTP. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214910,ECO:0000269|PubMed:11297618;Dbxref=dbSNP:rs56275071,PMID:11214910,PMID:11297618
GLUD1	P00367	307	353	318	318	Natural variant	ID=VAR_009270;Note=In HHF6. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10636977;Dbxref=dbSNP:rs121909736,PMID:10636977
GLUD1	P00367	307	353	318	318	Natural variant	ID=VAR_016762;Note=In HHF6%3B diminished sensitivity to GTP. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11297618;Dbxref=PMID:11297618
GLUD1	P00367	307	353	319	319	Natural variant	ID=VAR_016763;Note=In HHF6. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11297618;Dbxref=PMID:11297618
GLUD1	P00367	307	353	322	322	Natural variant	ID=VAR_016764;Note=In HHF6%3B diminished sensitivity to GTP. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11297618;Dbxref=PMID:11297618
GLUD1	P00367	307	353	322	322	Natural variant	ID=VAR_016765;Note=In HHF6%3B diminished sensitivity to GTP. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11214910,ECO:0000269|PubMed:11297618;Dbxref=dbSNP:rs121909737,PMID:11214910,PMID:11297618
GLUD1	P00367	307	353	349	349	Natural variant	ID=VAR_009271;Note=In HHF6. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10636977;Dbxref=dbSNP:rs121909735,PMID:10636977
GLUD1	P00367	498	519	498	498	Natural variant	ID=VAR_008666;Note=In HHF6. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9571255;Dbxref=dbSNP:rs121909731,PMID:9571255
GLUD1	P00367	498	519	499	499	Natural variant	ID=VAR_008667;Note=In HHF6. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9571255;Dbxref=dbSNP:rs121909734,PMID:9571255
GLUD1	P00367	498	519	499	499	Natural variant	ID=VAR_008668;Note=In HHF6. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9571255;Dbxref=dbSNP:rs121909733,PMID:9571255
GLUD1	P00367	498	519	501	501	Natural variant	ID=VAR_008669;Note=In HHF6. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9571255;Dbxref=dbSNP:rs121909732,PMID:9571255
GLUD1	P00367	498	519	507	507	Natural variant	ID=VAR_008670;Note=In HHF6%3B abolishes inhibition by ATP%3B no effect on activation by ADP. H->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11254391,ECO:0000269|PubMed:11903050,ECO:0000269|PubMed:9571255;Dbxref=dbSNP:rs121909730,PMID:11254391,PMID:11903050,PMID:9571255
GLUD1	P00367	498	519	501	501	Mutagenesis	Note=Reduces activity and inhibition by GTP. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11903050;Dbxref=PMID:11903050
GLUD1	P00367	498	519	507	507	Mutagenesis	Note=Strongly reduces inhibition by GTP. H->A
GLUD1	P00367	498	519	516	516	Mutagenesis	Note=Abolishes activation by ADP. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11903050;Dbxref=PMID:11903050
GLUD1	P00367	247	307	243	247	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	247	307	251	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	247	307	260	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	247	307	271	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	247	307	287	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	247	307	298	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	307	353	303	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	247	307	303	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	307	353	311	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	307	353	326	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	345	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	307	353	345	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	355	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	371	373	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	377	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	383	386	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	390	392	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	393	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	353	399	399	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	498	519	491	498	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
GLUD1	P00367	498	519	502	527	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1L1F
COPB1	P53618	852	882	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	655	715	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	579	655	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	355	404	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	852	882	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	655	715	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	579	655	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	355	404	2	953	Chain	ID=PRO_0000193833;Note=Coatomer subunit beta
COPB1	P53618	355	404	396	433	Repeat	Note=HEAT 6
COPB1	P53618	355	404	396	433	Repeat	Note=HEAT 6
DHX35	Q9H5Z1	58	89	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	89	115	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	115	150	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	284	337	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	467	499	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	531	557	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	628	651	1	703	Chain	ID=PRO_0000055168;Note=Probable ATP-dependent RNA helicase DHX35
DHX35	Q9H5Z1	58	89	64	229	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX35	Q9H5Z1	89	115	64	229	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX35	Q9H5Z1	115	150	64	229	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX35	Q9H5Z1	284	337	261	438	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX35	Q9H5Z1	58	89	77	84	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX35	Q9H5Z1	58	89	59	89	Alternative sequence	ID=VSP_047178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DHX35	Q9H5Z1	89	115	59	89	Alternative sequence	ID=VSP_047178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CYP4V2	Q6ZWL3	267	329	1	525	Chain	ID=PRO_0000051859;Note=Cytochrome P450 4V2
CYP4V2	Q6ZWL3	267	329	329	329	Binding site	Note=Heme (covalent%3B via 1 link);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51869
CYP4V2	Q6ZWL3	267	329	275	275	Natural variant	ID=VAR_055379;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs34745240
CMBL	Q96DG6	72	107	2	245	Chain	ID=PRO_0000308188;Note=Carboxymethylenebutenolidase homolog
CMBL	Q96DG6	72	107	99	99	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CMBL	Q96DG6	72	107	104	104	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLUH	O75153	1038	1065	1	1309	Chain	ID=PRO_0000123553;Note=Clustered mitochondria protein homolog
CLUH	O75153	758	809	1	1309	Chain	ID=PRO_0000123553;Note=Clustered mitochondria protein homolog
CLUH	O75153	1038	1065	1	1309	Chain	ID=PRO_0000123553;Note=Clustered mitochondria protein homolog
CLUH	O75153	758	809	1	1309	Chain	ID=PRO_0000123553;Note=Clustered mitochondria protein homolog
CLUH	O75153	1038	1065	1020	1053	Repeat	Note=TPR 2
CLUH	O75153	1038	1065	1020	1053	Repeat	Note=TPR 2
CAMTA1	Q9Y6Y1	146	170	1	1673	Chain	ID=PRO_0000235820;Note=Calmodulin-binding transcription activator 1
CAMTA1	Q9Y6Y1	146	170	63	188	DNA binding	Note=CG-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00767
CAMTA1	Q9Y6Y1	146	170	81	1673	Alternative sequence	ID=VSP_043843;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
CAMTA1	Q9Y6Y1	146	170	102	1673	Alternative sequence	ID=VSP_046359;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAMTA2	O94983	588	633	1	1202	Chain	ID=PRO_0000235821;Note=Calmodulin-binding transcription activator 2
CAMTA2	O94983	113	137	1	1202	Chain	ID=PRO_0000235821;Note=Calmodulin-binding transcription activator 2
CAMTA2	O94983	588	633	535	617	Domain	Note=IPT/TIG
CAMTA2	O94983	113	137	30	155	DNA binding	Note=CG-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00767
CAMTA2	O94983	588	633	1	873	Alternative sequence	ID=VSP_018489;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAMTA2	O94983	113	137	1	873	Alternative sequence	ID=VSP_018489;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAMTA2	O94983	113	137	114	137	Alternative sequence	ID=VSP_018492;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CMTR1	Q8N1G2	442	501	1	835	Chain	ID=PRO_0000251239;Note=Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CMTR1	Q8N1G2	679	701	1	835	Chain	ID=PRO_0000251239;Note=Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CMTR1	Q8N1G2	442	501	231	450	Domain	Note=RrmJ-type SAM-dependent 2'-O-MTase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00945
CMTR1	Q8N1G2	442	501	442	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N49
CMTR1	Q8N1G2	442	501	454	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N49
CMTR1	Q8N1G2	442	501	473	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N49
CMTR1	Q8N1G2	442	501	483	487	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N49
CMTR1	Q8N1G2	442	501	490	519	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N49
CNIH2	Q6PI25	50	66	1	160	Chain	ID=PRO_0000122225;Note=Protein cornichon homolog 2
CNIH2	Q6PI25	50	66	32	72	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	1	690	Chain	ID=PRO_0000219308;Note=cGMP-gated cation channel alpha-1
CNGA1	P29973	150	185	1	690	Chain	ID=PRO_0000219308;Note=cGMP-gated cation channel alpha-1
CNGA1	P29973	150	185	1	690	Chain	ID=PRO_0000219308;Note=cGMP-gated cation channel alpha-1
CNGA1	P29973	150	185	1	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	1	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	1	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	165	185	Transmembrane	Note=Helical%3B Name%3DH1;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	165	185	Transmembrane	Note=Helical%3B Name%3DH1;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	165	185	Transmembrane	Note=Helical%3B Name%3DH1;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA1	P29973	150	185	150	151	Sequence conflict	Note=EE->HH;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNGA1	P29973	150	185	150	151	Sequence conflict	Note=EE->HH;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNGA1	P29973	150	185	150	151	Sequence conflict	Note=EE->HH;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNGA3	Q16281	34	71	1	694	Chain	ID=PRO_0000219317;Note=Cyclic nucleotide-gated cation channel alpha-3
CNGA3	Q16281	132	149	1	694	Chain	ID=PRO_0000219317;Note=Cyclic nucleotide-gated cation channel alpha-3
CNGA3	Q16281	34	71	1	694	Chain	ID=PRO_0000219317;Note=Cyclic nucleotide-gated cation channel alpha-3
CNGA3	Q16281	132	149	1	694	Chain	ID=PRO_0000219317;Note=Cyclic nucleotide-gated cation channel alpha-3
CNGA3	Q16281	34	71	1	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA3	Q16281	132	149	1	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA3	Q16281	34	71	1	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA3	Q16281	132	149	1	166	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGA3	Q16281	34	71	1	71	Alternative sequence	ID=VSP_057075;Note=In isoform 3. MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIA->METRGLADSGQGSFTGQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQWCAEDGGDESEMALAGSPGCSSGPQG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNGA3	Q16281	34	71	1	71	Alternative sequence	ID=VSP_057075;Note=In isoform 3. MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIA->METRGLADSGQGSFTGQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQWCAEDGGDESEMALAGSPGCSSGPQG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNGA3	Q16281	132	149	132	150	Alternative sequence	ID=VSP_042525;Note=In isoform 2. SAWPLAKCNTNTSNNTEEE->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CNGA3	Q16281	132	149	132	150	Alternative sequence	ID=VSP_042525;Note=In isoform 2. SAWPLAKCNTNTSNNTEEE->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CNGA3	Q16281	34	71	48	48	Natural variant	ID=VAR_047565;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712225;Dbxref=dbSNP:rs62156348,PMID:15712225
CNGA3	Q16281	34	71	48	48	Natural variant	ID=VAR_047565;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15712225;Dbxref=dbSNP:rs62156348,PMID:15712225
DSP	P15924	199	242	1	2871	Chain	ID=PRO_0000078144;Note=Desmoplakin
DSP	P15924	1028	1793	1	2871	Chain	ID=PRO_0000078144;Note=Desmoplakin
DSP	P15924	199	242	178	271	Repeat	Note=Spectrin 1
DSP	P15924	199	242	1	1056	Region	Note=Globular 1
DSP	P15924	1028	1793	1	1056	Region	Note=Globular 1
DSP	P15924	199	242	1	584	Region	Note=Interaction with plakophilin 1 and junction plakoglobin
DSP	P15924	1028	1793	1057	1945	Region	Note=Central fibrous rod domain
DSP	P15924	1028	1793	1018	1945	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DSP	P15924	1028	1793	1658	1658	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DSP	P15924	1028	1793	1708	1708	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
DSP	P15924	1028	1793	1195	1793	Alternative sequence	ID=VSP_005070;Note=In isoform DPII. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DSP	P15924	1028	1793	1351	1793	Alternative sequence	ID=VSP_053769;Note=In isoform DSPIa. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20524011;Dbxref=PMID:20524011
DSP	P15924	1028	1793	1255	1255	Natural variant	ID=VAR_023814;Note=In ARVD8. R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15941723,ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs777407386,PMID:15941723,PMID:20031617
DSP	P15924	1028	1793	1505	1505	Natural variant	ID=VAR_065694;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs375919492,PMID:20031617
DSP	P15924	1028	1793	1512	1512	Natural variant	ID=VAR_020468;Note=Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19863551,ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs2076299,PMID:19863551,PMID:20031617
DSP	P15924	1028	1793	1526	1526	Natural variant	ID=VAR_065695;Note=N->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19863551,ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs28763966,PMID:19863551,PMID:20031617
DSP	P15924	1028	1793	1537	1537	Natural variant	ID=VAR_065696;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19863551,ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs28763967,PMID:19863551,PMID:20031617
DSP	P15924	1028	1793	1738	1738	Natural variant	ID=VAR_023815;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19863551,ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs6929069,PMID:19863551,PMID:20031617
DSP	P15924	1028	1793	1775	1775	Natural variant	ID=VAR_023816;Note=In ARVD8%3B unknown pathological significance. R->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15941723,ECO:0000269|PubMed:20031617;Dbxref=dbSNP:rs34738426,PMID:15941723,PMID:20031617
DSP	P15924	1028	1793	1120	1120	Sequence conflict	Note=D->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
DSP	P15924	199	242	182	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R6N
DSP	P15924	199	242	211	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R6N
CNPPD1	Q9BV87	127	170	1	410	Chain	ID=PRO_0000089352;Note=Protein CNPPD1
CNPPD1	Q9BV87	127	170	1	410	Chain	ID=PRO_0000089352;Note=Protein CNPPD1
CNOT6L	Q96LI5	133	163	1	555	Chain	ID=PRO_0000314587;Note=CCR4-NOT transcription complex subunit 6-like
CNOT6L	Q96LI5	133	163	126	148	Repeat	Note=LRR 4
CNOT6L	Q96LI5	133	163	1	152	Region	Note=Required for interaction with CNOT1%2C CNOT3 and CNOT7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17452450;Dbxref=PMID:17452450
CNOT6L	Q96LI5	133	163	158	555	Region	Note=Nuclease domain
CNOT6L	Q96LI5	133	163	127	153	Alternative sequence	ID=VSP_030321;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNTN1	Q12860	20	31	1	20	Signal peptide	.
CNTN1	Q12860	20	31	1	20	Signal peptide	.
CNTN1	Q12860	20	31	21	993	Chain	ID=PRO_0000014685;Note=Contactin-1
CNTN1	Q12860	20	31	21	993	Chain	ID=PRO_0000014685;Note=Contactin-1
CNTN1	Q12860	20	31	21	31	Alternative sequence	ID=VSP_002500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7959734;Dbxref=PMID:7959734
CNTN1	Q12860	20	31	21	31	Alternative sequence	ID=VSP_002500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7959734;Dbxref=PMID:7959734
CNPY3	Q9BT09	124	165	31	278	Chain	ID=PRO_0000313780;Note=Protein canopy homolog 3
CNPY3	Q9BT09	124	165	47	271	Domain	Note=Saposin B-type
CNPY3	Q9BT09	124	165	153	179	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CNPY3	Q9BT09	124	165	153	153	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CNPY3	Q9BT09	124	165	49	206	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNPY3	Q9BT09	124	165	52	194	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNPY3	Q9BT09	124	165	104	166	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNPY3	Q9BT09	124	165	55	278	Alternative sequence	ID=VSP_030133;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CNPY3	Q9BT09	124	165	125	125	Natural variant	ID=VAR_080491;Note=In EIEE60%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29394991;Dbxref=PMID:29394991
CNPY3	Q9BT09	124	165	145	145	Natural variant	ID=VAR_037731;Note=M->I;Dbxref=dbSNP:rs1063252
CNTN4	Q8IWV2	594	647	19	1000	Chain	ID=PRO_0000014711;Note=Contactin-4
CNTN4	Q8IWV2	594	647	19	1000	Chain	ID=PRO_0000014711;Note=Contactin-4
CNTN4	Q8IWV2	594	647	19	1000	Chain	ID=PRO_0000014711;Note=Contactin-4
CNTN4	Q8IWV2	594	647	599	697	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CNTN4	Q8IWV2	594	647	599	697	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CNTN4	Q8IWV2	594	647	599	697	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CNTN4	Q8IWV2	594	647	1	744	Alternative sequence	ID=VSP_011961;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12202991;Dbxref=PMID:12202991
CNTN4	Q8IWV2	594	647	1	744	Alternative sequence	ID=VSP_011961;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12202991;Dbxref=PMID:12202991
CNTN4	Q8IWV2	594	647	1	744	Alternative sequence	ID=VSP_011961;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12202991;Dbxref=PMID:12202991
CNTNAP5	Q8WYK1	916	996	25	1306	Chain	ID=PRO_0000317377;Note=Contactin-associated protein-like 5
CNTNAP5	Q8WYK1	916	996	25	1237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP5	Q8WYK1	916	996	791	956	Domain	Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CNTNAP5	Q8WYK1	916	996	957	995	Domain	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CNTNAP5	Q8WYK1	916	996	929	956	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP5	Q8WYK1	916	996	960	973	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP5	Q8WYK1	916	996	967	982	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP5	Q8WYK1	916	996	984	994	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNTNAP5	Q8WYK1	916	996	957	962	Sequence conflict	Note=PGHCSS->SIKKLK;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPCDC	Q96CD2	45	77	1	204	Chain	ID=PRO_0000182030;Note=Phosphopantothenoylcysteine decarboxylase
PPCDC	Q96CD2	77	120	1	204	Chain	ID=PRO_0000182030;Note=Phosphopantothenoylcysteine decarboxylase
PPCDC	Q96CD2	77	120	104	107	Nucleotide binding	Note=FMN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14501115;Dbxref=PMID:14501115
PPCDC	Q96CD2	45	77	59	59	Binding site	Note=FMN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14501115;Dbxref=PMID:14501115
PPCDC	Q96CD2	45	77	1	78	Alternative sequence	ID=VSP_044802;Note=In isoform 2. MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEI->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PPCDC	Q96CD2	77	120	1	78	Alternative sequence	ID=VSP_044802;Note=In isoform 2. MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEI->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PPCDC	Q96CD2	77	120	78	78	Natural variant	ID=VAR_068974;Note=I->M;Dbxref=dbSNP:rs2304899
PPCDC	Q96CD2	45	77	49	49	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPCDC	Q96CD2	45	77	46	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	45	77	55	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	45	77	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	45	77	72	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	77	120	72	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	77	120	87	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	77	120	96	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	77	120	105	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
PPCDC	Q96CD2	77	120	119	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QZU
DGKI	O75912	879	919	1	1065	Chain	ID=PRO_0000218466;Note=Diacylglycerol kinase iota
DGKI	O75912	794	809	1	1065	Chain	ID=PRO_0000218466;Note=Diacylglycerol kinase iota
DGKI	O75912	749	767	1	1065	Chain	ID=PRO_0000218466;Note=Diacylglycerol kinase iota
DGKI	O75912	437	475	1	1065	Chain	ID=PRO_0000218466;Note=Diacylglycerol kinase iota
DGKI	O75912	437	475	372	507	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
COL12A1	Q99715	2859	2883	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	2755	2773	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	2726	2755	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	2290	2315	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	2202	2241	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	2153	2202	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	812	903	24	3063	Chain	ID=PRO_0000005783;Note=Collagen alpha-1(XII) chain
COL12A1	Q99715	812	903	725	816	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL12A1	Q99715	812	903	817	905	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL12A1	Q99715	2202	2241	2118	2206	Domain	Note=Fibronectin type-III 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL12A1	Q99715	2153	2202	2118	2206	Domain	Note=Fibronectin type-III 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL12A1	Q99715	2290	2315	2207	2294	Domain	Note=Fibronectin type-III 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL12A1	Q99715	2202	2241	2207	2294	Domain	Note=Fibronectin type-III 18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
COL12A1	Q99715	2755	2773	2747	2798	Domain	Note=Collagen-like 1
COL12A1	Q99715	2726	2755	2747	2798	Domain	Note=Collagen-like 1
COL12A1	Q99715	2859	2883	2853	2898	Domain	Note=Collagen-like 3
COL12A1	Q99715	2726	2755	2451	2746	Region	Note=Nonhelical region (NC3)
COL12A1	Q99715	2859	2883	2747	2898	Region	Note=Triple-helical region (COL2) with 1 imperfection
COL12A1	Q99715	2755	2773	2747	2898	Region	Note=Triple-helical region (COL2) with 1 imperfection
COL12A1	Q99715	2726	2755	2747	2898	Region	Note=Triple-helical region (COL2) with 1 imperfection
COL12A1	Q99715	812	903	862	864	Motif	Note=Cell attachment site;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL12A1	Q99715	812	903	889	889	Glycosylation	Note=O-linked (Xyl...) (chondroitin sulfate) serine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL12A1	Q99715	2202	2241	2206	2206	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL12A1	Q99715	812	903	25	1188	Alternative sequence	ID=VSP_001149;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9143499;Dbxref=PMID:9143499
COL12A1	Q99715	2726	2755	2651	2726	Alternative sequence	ID=VSP_024942;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL12A1	Q99715	2153	2202	2160	2160	Natural variant	ID=VAR_048770;Note=E->V;Dbxref=dbSNP:rs35523808
COL12A1	Q99715	812	903	813	813	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
COG1	Q8WTW3	740	794	2	980	Chain	ID=PRO_0000213491;Note=Conserved oligomeric Golgi complex subunit 1
COG1	Q8WTW3	740	794	744	744	Natural variant	ID=VAR_048756;Note=Y->C;Dbxref=dbSNP:rs7208207
COL28A1	Q2UY09	762	774	24	1125	Chain	ID=PRO_5000074667;Note=Collagen alpha-1(XXVIII) chain
COL28A1	Q2UY09	620	643	24	1125	Chain	ID=PRO_5000074667;Note=Collagen alpha-1(XXVIII) chain
COL28A1	Q2UY09	597	620	24	1125	Chain	ID=PRO_5000074667;Note=Collagen alpha-1(XXVIII) chain
COL28A1	Q2UY09	503	527	24	1125	Chain	ID=PRO_5000074667;Note=Collagen alpha-1(XXVIII) chain
COL28A1	Q2UY09	434	457	24	1125	Chain	ID=PRO_5000074667;Note=Collagen alpha-1(XXVIII) chain
COL28A1	Q2UY09	503	527	501	544	Domain	Note=Collagen-like 4
COL28A1	Q2UY09	762	774	730	769	Domain	Note=Collagen-like 6
COL28A1	Q2UY09	762	774	335	1125	Alternative sequence	ID=VSP_031092;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16330543;Dbxref=PMID:16330543
COL28A1	Q2UY09	620	643	335	1125	Alternative sequence	ID=VSP_031092;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16330543;Dbxref=PMID:16330543
COL28A1	Q2UY09	597	620	335	1125	Alternative sequence	ID=VSP_031092;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16330543;Dbxref=PMID:16330543
COL28A1	Q2UY09	503	527	335	1125	Alternative sequence	ID=VSP_031092;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16330543;Dbxref=PMID:16330543
COL28A1	Q2UY09	434	457	335	1125	Alternative sequence	ID=VSP_031092;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16330543;Dbxref=PMID:16330543
COL28A1	Q2UY09	762	774	714	1125	Alternative sequence	ID=VSP_031094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16330543;Dbxref=PMID:16330543
COL28A1	Q2UY09	434	457	437	437	Natural variant	ID=VAR_061117;Note=I->M;Dbxref=dbSNP:rs55745506
CEP89	Q96ST8	625	655	1	783	Chain	ID=PRO_0000288809;Note=Centrosomal protein of 89 kDa
CEP89	Q96ST8	343	360	1	783	Chain	ID=PRO_0000288809;Note=Centrosomal protein of 89 kDa
CEP89	Q96ST8	222	295	1	783	Chain	ID=PRO_0000288809;Note=Centrosomal protein of 89 kDa
CEP89	Q96ST8	222	295	234	333	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP89	Q96ST8	625	655	369	719	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP89	Q96ST8	222	295	1	247	Alternative sequence	ID=VSP_039181;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CEP89	Q96ST8	343	360	344	356	Alternative sequence	ID=VSP_039182;Note=In isoform 3. SLNIEGLPSKGPI->VTFPIVKISFSDF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP89	Q96ST8	625	655	357	782	Alternative sequence	ID=VSP_039183;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP89	Q96ST8	343	360	357	782	Alternative sequence	ID=VSP_039183;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CERS5	Q8N5B7	212	255	1	392	Chain	ID=PRO_0000185514;Note=Ceramide synthase 5
CERS5	Q8N5B7	181	212	1	392	Chain	ID=PRO_0000185514;Note=Ceramide synthase 5
CERS5	Q8N5B7	181	212	169	182	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS5	Q8N5B7	181	212	183	203	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS5	Q8N5B7	212	255	204	213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS5	Q8N5B7	181	212	204	213	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS5	Q8N5B7	212	255	214	234	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS5	Q8N5B7	212	255	235	271	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS5	Q8N5B7	212	255	139	340	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS5	Q8N5B7	181	212	139	340	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CSGALNACT1	Q8TDX6	284	317	1	532	Chain	ID=PRO_0000189564;Note=Chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT1	Q8TDX6	284	317	1	532	Chain	ID=PRO_0000189564;Note=Chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT1	Q8TDX6	284	317	1	532	Chain	ID=PRO_0000189564;Note=Chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT1	Q8TDX6	284	317	36	532	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSGALNACT1	Q8TDX6	284	317	36	532	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSGALNACT1	Q8TDX6	284	317	36	532	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSGALNACT1	Q8TDX6	284	317	315	315	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSGALNACT1	Q8TDX6	284	317	315	315	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSGALNACT1	Q8TDX6	284	317	315	315	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSGALNACT1	Q8TDX6	284	317	285	532	Alternative sequence	ID=VSP_012728;Note=In isoform 3. EMCIEQDGRVHLTVVYFGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT->PADEVFRCVPLSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CSGALNACT1	Q8TDX6	284	317	285	532	Alternative sequence	ID=VSP_012728;Note=In isoform 3. EMCIEQDGRVHLTVVYFGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT->PADEVFRCVPLSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CSGALNACT1	Q8TDX6	284	317	285	532	Alternative sequence	ID=VSP_012728;Note=In isoform 3. EMCIEQDGRVHLTVVYFGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT->PADEVFRCVPLSP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CSGALNACT1	Q8TDX6	284	317	312	312	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSGALNACT1	Q8TDX6	284	317	312	312	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CSGALNACT1	Q8TDX6	284	317	312	312	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD1	O14646	1369	1416	1	1710	Chain	ID=PRO_0000080224;Note=Chromodomain-helicase-DNA-binding protein 1
CHD1	O14646	856	906	1	1710	Chain	ID=PRO_0000080224;Note=Chromodomain-helicase-DNA-binding protein 1
CHD1	O14646	781	832	1	1710	Chain	ID=PRO_0000080224;Note=Chromodomain-helicase-DNA-binding protein 1
CHD1	O14646	146	195	1	1710	Chain	ID=PRO_0000080224;Note=Chromodomain-helicase-DNA-binding protein 1
CHD1	O14646	856	906	792	943	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
CHD1	O14646	781	832	792	943	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
CHD1	O14646	1369	1416	1371	1371	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
CHD1	O14646	1369	1416	1373	1373	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O14647
CHD1	O14646	1369	1416	1411	1420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2N39
CHIC1	Q5VXU3	188	208	1	224	Chain	ID=PRO_0000189554;Note=Cysteine-rich hydrophobic domain-containing protein 1
CHIC1	Q5VXU3	188	208	189	208	Alternative sequence	ID=VSP_034830;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
CHMP1A	Q9HD42	35	84	1	196	Chain	ID=PRO_0000211448;Note=Charged multivesicular body protein 1a
CHMP1A	Q9HD42	9	35	1	196	Chain	ID=PRO_0000211448;Note=Charged multivesicular body protein 1a
CHMP1A	Q9HD42	35	84	5	47	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CHMP1A	Q9HD42	9	35	5	47	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CHMP1A	Q9HD42	35	84	1	128	Alternative sequence	ID=VSP_051716;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHMP1A	Q9HD42	9	35	1	128	Alternative sequence	ID=VSP_051716;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHMP1A	Q9HD42	35	84	77	77	Sequence conflict	Note=Q->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX6	P26196	288	331	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	166	215	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	88	123	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	288	331	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	166	215	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	88	123	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	288	331	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	166	215	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	288	331	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	166	215	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	288	331	308	468	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX6	P26196	288	331	308	468	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX6	P26196	88	123	96	124	Motif	Note=Q motif
DDX6	P26196	88	123	96	124	Motif	Note=Q motif
DDX6	P26196	288	331	320	320	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-323%3B A-327 and A-331. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	320	320	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-323%3B A-327 and A-331. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	323	323	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-327 and A-331. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	323	323	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-327 and A-331. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	327	327	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-331. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	327	327	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-331. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	331	331	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-327. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	331	331	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-327. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	293	293	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX6	P26196	288	331	293	293	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX6	P26196	88	123	98	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	98	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	105	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	105	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	121	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	121	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	167	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	167	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	174	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	174	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	196	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	196	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	205	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	205	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	282	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	282	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	309	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	309	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	318	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	318	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	321	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	321	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
CLEC2D	Q9UHP7	20	57	1	191	Chain	ID=PRO_0000315285;Note=C-type lectin domain family 2 member D
CLEC2D	Q9UHP7	20	57	1	38	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC2D	Q9UHP7	20	57	39	59	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC2D	Q9UHP7	20	57	21	57	Alternative sequence	ID=VSP_039676;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20843815;Dbxref=PMID:20843815
CLEC2D	Q9UHP7	20	57	23	23	Natural variant	ID=VAR_038173;Note=L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:20843815;Dbxref=dbSNP:rs3764022,PMID:15489334,PMID:20843815
C12orf50	Q8NA57	233	272	1	414	Chain	ID=PRO_0000295234;Note=Uncharacterized protein C12orf50
CLEC4A	Q9UMR7	66	99	1	237	Chain	ID=PRO_0000046612;Note=C-type lectin domain family 4 member A
CLEC4A	Q9UMR7	66	99	49	69	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4A	Q9UMR7	66	99	70	237	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4A	Q9UMR7	66	99	28	99	Alternative sequence	ID=VSP_012842;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11178971;Dbxref=PMID:11178971
CLEC4A	Q9UMR7	66	99	28	67	Alternative sequence	ID=VSP_041348;Note=In isoform 3. ASKERTAPHKSNTGFPKLLCASLLIFFLLLAISFFIAFVI->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11178971;Dbxref=PMID:11178971
CLEC4A	Q9UMR7	66	99	67	100	Alternative sequence	ID=VSP_012844;Note=In isoform 2. IFFQKYSQLLEKKTTKELVHTTLECVKKNMPVEE->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11994513;Dbxref=PMID:11994513
CLTB	P09497	155	172	1	229	Chain	ID=PRO_0000205771;Note=Clathrin light chain B
CLTB	P09497	155	172	93	155	Region	Note=Involved in binding clathrin heavy chain
CLTB	P09497	155	172	156	173	Alternative sequence	ID=VSP_001098;Note=In isoform Non-brain. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2,ECO:0000303|Ref.3;Dbxref=PMID:15489334
CLCN1	P35523	836	865	1	988	Chain	ID=PRO_0000094429;Note=Chloride channel protein 1
CLCN1	P35523	836	865	579	988	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLCN1	P35523	836	865	821	876	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCN1	P35523	836	865	845	845	Natural variant	ID=VAR_075613;Note=In MCAR%3B unknown pathological significance%3B no effect on chloride channel activity. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22521272;Dbxref=dbSNP:rs755433272,PMID:22521272
CLCN1	P35523	836	865	855	855	Natural variant	ID=VAR_075614;Note=In MCAR%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26502825;Dbxref=PMID:26502825
CLCN1	P35523	836	865	834	843	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6COZ
CLCN1	P35523	836	865	851	853	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6COZ
CLCN1	P35523	836	865	856	860	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6COZ
CLCN1	P35523	836	865	863	875	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6COZ
CLEC18C	Q8NCF0	72	152	27	446	Chain	ID=PRO_0000324317;Note=C-type lectin domain family 18 member C
CLEC18C	Q8NCF0	261	292	27	446	Chain	ID=PRO_0000324317;Note=C-type lectin domain family 18 member C
CLEC18C	Q8NCF0	72	152	27	446	Chain	ID=PRO_0000324317;Note=C-type lectin domain family 18 member C
CLEC18C	Q8NCF0	261	292	27	446	Chain	ID=PRO_0000324317;Note=C-type lectin domain family 18 member C
CLEC18C	Q8NCF0	72	152	27	446	Chain	ID=PRO_0000324317;Note=C-type lectin domain family 18 member C
CLEC18C	Q8NCF0	261	292	27	446	Chain	ID=PRO_0000324317;Note=C-type lectin domain family 18 member C
CLEC18C	Q8NCF0	72	152	52	182	Domain	Note=SCP
CLEC18C	Q8NCF0	72	152	52	182	Domain	Note=SCP
CLEC18C	Q8NCF0	72	152	52	182	Domain	Note=SCP
CLEC18C	Q8NCF0	261	292	228	261	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CLEC18C	Q8NCF0	261	292	228	261	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CLEC18C	Q8NCF0	261	292	228	261	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CLEC18C	Q8NCF0	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18C	Q8NCF0	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18C	Q8NCF0	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18C	Q8NCF0	72	152	91	91	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC18C	Q8NCF0	72	152	91	91	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC18C	Q8NCF0	72	152	91	91	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC18C	Q8NCF0	72	152	100	100	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC18C	Q8NCF0	72	152	100	100	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC18C	Q8NCF0	72	152	100	100	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLK1	P49759	183	221	1	484	Chain	ID=PRO_0000085866;Note=Dual specificity protein kinase CLK1
CLK1	P49759	183	221	161	477	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CLK1	P49759	183	221	191	191	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CLK1	P49759	183	221	137	484	Alternative sequence	ID=VSP_004853;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7990150;Dbxref=PMID:14702039,PMID:15489334,PMID:7990150
CLK1	P49759	183	221	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FT8
CLK1	P49759	183	221	187	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FT8
CLK1	P49759	183	221	197	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6FT8
CLIP1	P30622	1072	1111	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	806	845	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	456	491	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	335	401	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	1072	1111	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	806	845	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	456	491	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	335	401	1	1438	Chain	ID=PRO_0000083527;Note=CAP-Gly domain-containing linker protein 1
CLIP1	P30622	1072	1111	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	806	845	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	456	491	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	335	401	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	1072	1111	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	806	845	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	456	491	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	335	401	350	1353	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP1	P30622	335	401	348	348	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JK25
CLIP1	P30622	335	401	348	348	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JK25
CLIP1	P30622	456	491	457	502	Alternative sequence	ID=VSP_000765;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1356075,ECO:0000303|PubMed:15489334;Dbxref=PMID:1356075,PMID:15489334
CLIP1	P30622	456	491	457	502	Alternative sequence	ID=VSP_000765;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1356075,ECO:0000303|PubMed:15489334;Dbxref=PMID:1356075,PMID:15489334
CLIP1	P30622	456	491	457	467	Alternative sequence	ID=VSP_038201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1600942;Dbxref=PMID:1600942
CLIP1	P30622	456	491	457	467	Alternative sequence	ID=VSP_038201;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1600942;Dbxref=PMID:1600942
CLIP1	P30622	1072	1111	1080	1080	Natural variant	ID=VAR_020398;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1356075,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1129167,PMID:1356075,PMID:15489334
CLIP1	P30622	1072	1111	1080	1080	Natural variant	ID=VAR_020398;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1356075,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1129167,PMID:1356075,PMID:15489334
CLIP2	Q9UDT6	460	495	1	1046	Chain	ID=PRO_0000083515;Note=CAP-Gly domain-containing linker protein 2
CLIP2	Q9UDT6	826	854	1	1046	Chain	ID=PRO_0000083515;Note=CAP-Gly domain-containing linker protein 2
CLIP2	Q9UDT6	1022	1043	1	1046	Chain	ID=PRO_0000083515;Note=CAP-Gly domain-containing linker protein 2
CLIP2	Q9UDT6	460	495	1	1046	Chain	ID=PRO_0000083515;Note=CAP-Gly domain-containing linker protein 2
CLIP2	Q9UDT6	826	854	1	1046	Chain	ID=PRO_0000083515;Note=CAP-Gly domain-containing linker protein 2
CLIP2	Q9UDT6	1022	1043	1	1046	Chain	ID=PRO_0000083515;Note=CAP-Gly domain-containing linker protein 2
CLIP2	Q9UDT6	460	495	354	524	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP2	Q9UDT6	460	495	354	524	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP2	Q9UDT6	826	854	673	1016	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP2	Q9UDT6	826	854	673	1016	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP2	Q9UDT6	460	495	461	495	Alternative sequence	ID=VSP_015682;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9179496;Dbxref=PMID:9179496
CLIP2	Q9UDT6	460	495	461	495	Alternative sequence	ID=VSP_015682;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9179496;Dbxref=PMID:9179496
NCAPG2	Q86XI2	978	1025	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	796	835	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	605	663	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	442	493	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	382	442	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	978	1025	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	796	835	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	605	663	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	442	493	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	382	442	1	1143	Chain	ID=PRO_0000255942;Note=Condensin-2 complex subunit G2
NCAPG2	Q86XI2	442	493	460	498	Repeat	Note=HEAT
NCAPG2	Q86XI2	442	493	460	498	Repeat	Note=HEAT
NCAPG2	Q86XI2	796	835	805	805	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
NCAPG2	Q86XI2	796	835	805	805	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
CNN1	P51911	84	130	1	297	Chain	ID=PRO_0000204767;Note=Calponin-1
CNN1	P51911	130	167	1	297	Chain	ID=PRO_0000204767;Note=Calponin-1
CNN1	P51911	167	216	1	297	Chain	ID=PRO_0000204767;Note=Calponin-1
CNN1	P51911	84	130	28	131	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CNN1	P51911	130	167	28	131	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CNN1	P51911	130	167	164	189	Repeat	Note=Calponin-like 1
CNN1	P51911	167	216	164	189	Repeat	Note=Calponin-like 1
CNN1	P51911	167	216	204	229	Repeat	Note=Calponin-like 2
CNN1	P51911	167	216	170	170	Modified residue	Note=Phosphothreonine%3B by ROCK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNN1	P51911	167	216	175	175	Modified residue	Note=Phosphoserine%3B by ROCK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNN1	P51911	167	216	180	180	Modified residue	Note=Phosphothreonine%3B by ROCK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNN1	P51911	167	216	184	184	Modified residue	Note=Phosphothreonine%3B by ROCK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CNN1	P51911	130	167	149	149	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNN1	P51911	167	216	170	170	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNN1	P51911	84	130	82	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYP
CNN1	P51911	84	130	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYP
CNN1	P51911	84	130	108	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYP
CNN1	P51911	84	130	118	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYP
CNN1	P51911	130	167	118	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYP
CNTN5	O94779	18	92	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTN5	O94779	18	92	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTN5	O94779	18	92	19	1072	Chain	ID=PRO_0000014717;Note=Contactin-5
CNTN5	O94779	18	92	19	1072	Chain	ID=PRO_0000014717;Note=Contactin-5
CNTN5	O94779	18	92	19	92	Alternative sequence	ID=VSP_011967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11013081;Dbxref=PMID:11013081
CNTN5	O94779	18	92	19	92	Alternative sequence	ID=VSP_011967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11013081;Dbxref=PMID:11013081
CNTN5	O94779	18	92	23	23	Natural variant	ID=VAR_019907;Note=S->A;Dbxref=dbSNP:rs10790978
CNTN5	O94779	18	92	23	23	Natural variant	ID=VAR_019907;Note=S->A;Dbxref=dbSNP:rs10790978
CNTN5	O94779	18	92	70	70	Natural variant	ID=VAR_019908;Note=L->R;Dbxref=dbSNP:rs7125822
CNTN5	O94779	18	92	70	70	Natural variant	ID=VAR_019908;Note=L->R;Dbxref=dbSNP:rs7125822
CNTN5	O94779	18	92	81	81	Natural variant	ID=VAR_019909;Note=N->S;Dbxref=dbSNP:rs10893933
CNTN5	O94779	18	92	81	81	Natural variant	ID=VAR_019909;Note=N->S;Dbxref=dbSNP:rs10893933
CNTNAP1	P78357	1271	1287	20	1384	Chain	ID=PRO_0000019503;Note=Contactin-associated protein 1
CNTNAP1	P78357	1271	1287	20	1283	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP1	P78357	1271	1287	1284	1304	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTNAP1	P78357	1271	1287	623	1384	Natural variant	ID=VAR_078820;Note=In LCCS7%3B also found in a patient with congenital hypomyelinating neuropathy. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27782105,ECO:0000269|PubMed:27818385;Dbxref=PMID:27782105,PMID:27818385
CNTNAP1	P78357	1271	1287	671	1384	Natural variant	ID=VAR_078821;Note=Probable disease-associated mutation found in a patient with congenital hypomyelinating neuropathy. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27818385,ECO:0000269|PubMed:28374019;Dbxref=PMID:27818385,PMID:28374019
CNTNAP1	P78357	1271	1287	672	1384	Natural variant	ID=VAR_078822;Note=In LCCS7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28374019;Dbxref=PMID:28374019
CNTROB	Q8N137	276	309	1	903	Chain	ID=PRO_0000076240;Note=Centrobin
CNTROB	Q8N137	482	523	1	903	Chain	ID=PRO_0000076240;Note=Centrobin
CNTROB	Q8N137	736	793	1	903	Chain	ID=PRO_0000076240;Note=Centrobin
CNTROB	Q8N137	482	523	365	903	Region	Note=Required for centrosome localization
CNTROB	Q8N137	736	793	365	903	Region	Note=Required for centrosome localization
CNTROB	Q8N137	276	309	196	560	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTROB	Q8N137	482	523	196	560	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTROB	Q8N137	736	793	573	777	Compositional bias	Note=Pro-rich
CNTROB	Q8N137	736	793	790	790	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CNTROB	Q8N137	736	793	555	903	Alternative sequence	ID=VSP_016837;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
COL4A4	P53420	1444	1507	39	1690	Chain	ID=PRO_0000005850;Note=Collagen alpha-4(IV) chain
COL4A4	P53420	1405	1444	39	1690	Chain	ID=PRO_0000005850;Note=Collagen alpha-4(IV) chain
COL4A4	P53420	1071	1096	39	1690	Chain	ID=PRO_0000005850;Note=Collagen alpha-4(IV) chain
COL4A4	P53420	685	721	39	1690	Chain	ID=PRO_0000005850;Note=Collagen alpha-4(IV) chain
COL4A4	P53420	231	245	39	1690	Chain	ID=PRO_0000005850;Note=Collagen alpha-4(IV) chain
COL4A4	P53420	1444	1507	1465	1690	Domain	Note=Collagen IV NC1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00736
COL4A4	P53420	1444	1507	65	1459	Region	Note=Triple-helical region
COL4A4	P53420	1405	1444	65	1459	Region	Note=Triple-helical region
COL4A4	P53420	1071	1096	65	1459	Region	Note=Triple-helical region
COL4A4	P53420	685	721	65	1459	Region	Note=Triple-helical region
COL4A4	P53420	231	245	65	1459	Region	Note=Triple-helical region
COL4A4	P53420	1444	1507	1480	1569	Disulfide bond	Note=Or C-1480 with C-1566;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00736
C5	P01031	502	572	19	673	Chain	ID=PRO_0000005985;Note=Complement C5 beta chain
C5	P01031	372	434	19	673	Chain	ID=PRO_0000005985;Note=Complement C5 beta chain
C5	P01031	1559	1587	678	1676	Chain	ID=PRO_0000005987;Note=Complement C5 alpha chain
C5	P01031	1501	1529	678	1676	Chain	ID=PRO_0000005987;Note=Complement C5 alpha chain
C5	P01031	1288	1339	678	1676	Chain	ID=PRO_0000005987;Note=Complement C5 alpha chain
C5	P01031	950	980	678	1676	Chain	ID=PRO_0000005987;Note=Complement C5 alpha chain
C5	P01031	1559	1587	752	1676	Chain	ID=PRO_0000005989;Note=Complement C5 alpha' chain
C5	P01031	1501	1529	752	1676	Chain	ID=PRO_0000005989;Note=Complement C5 alpha' chain
C5	P01031	1288	1339	752	1676	Chain	ID=PRO_0000005989;Note=Complement C5 alpha' chain
C5	P01031	950	980	752	1676	Chain	ID=PRO_0000005989;Note=Complement C5 alpha' chain
C5	P01031	1559	1587	1532	1676	Domain	Note=NTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00295
C5	P01031	502	572	567	810	Disulfide bond	.
C5	P01031	1501	1529	866	1527	Disulfide bond	.
C5	P01031	1288	1339	866	1527	Disulfide bond	.
C5	P01031	950	980	866	1527	Disulfide bond	.
C5	P01031	1501	1529	1375	1505	Disulfide bond	.
C5	P01031	1501	1529	1520	1525	Disulfide bond	.
C5	P01031	1559	1587	1532	1606	Disulfide bond	.
C5	P01031	1559	1587	1553	1676	Disulfide bond	.
C5	P01031	372	434	389	389	Natural variant	ID=VAR_023946;Note=T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15488949,ECO:0000269|PubMed:1984448;Dbxref=PMID:15488949,PMID:1984448
C5	P01031	502	572	518	518	Natural variant	ID=VAR_001996;Note=F->S
C5	P01031	950	980	966	966	Natural variant	ID=VAR_048823;Note=Polymorphism%3B confirmed at protein level. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22028381;Dbxref=dbSNP:rs2230212,PMID:22028381
C5	P01031	1288	1339	1310	1310	Natural variant	ID=VAR_014576;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs17610
C5	P01031	372	434	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	372	434	378	380	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5W
C5	P01031	372	434	387	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	372	434	401	403	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	372	434	407	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	372	434	413	415	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	372	434	416	422	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	372	434	428	437	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	498	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	508	516	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	519	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU7
C5	P01031	502	572	524	529	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	532	534	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	536	546	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	548	550	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	553	563	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	502	572	571	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	950	980	949	952	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	950	980	956	959	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	950	980	974	982	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1288	1339	1287	1303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1288	1339	1310	1317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1288	1339	1324	1332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1288	1339	1338	1340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5W
C5	P01031	1501	1529	1500	1509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1501	1529	1522	1524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1501	1529	1526	1529	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1559	1587	1559	1571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
C5	P01031	1559	1587	1574	1590	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HCC
COL6A1	P12109	319	334	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	334	352	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	394	412	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	445	466	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	508	525	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	525	537	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	558	580	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	811	821	20	1028	Chain	ID=PRO_0000005758;Note=Collagen alpha-1(VI) chain
COL6A1	P12109	319	334	257	592	Region	Note=Triple-helical region
COL6A1	P12109	334	352	257	592	Region	Note=Triple-helical region
COL6A1	P12109	394	412	257	592	Region	Note=Triple-helical region
COL6A1	P12109	445	466	257	592	Region	Note=Triple-helical region
COL6A1	P12109	508	525	257	592	Region	Note=Triple-helical region
COL6A1	P12109	525	537	257	592	Region	Note=Triple-helical region
COL6A1	P12109	558	580	257	592	Region	Note=Triple-helical region
COL6A1	P12109	811	821	593	1028	Region	Note=C-terminal globular domain
COL6A1	P12109	508	525	516	516	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
COL6A1	P12109	525	537	537	537	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
COL6A1	P12109	319	334	332	332	Natural variant	ID=VAR_058220;Note=G->S;Dbxref=dbSNP:rs11701912
COL6A1	P12109	334	352	341	341	Natural variant	ID=VAR_013582;Note=In BTHLM1. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11865138;Dbxref=dbSNP:rs121912935,PMID:11865138
COL6A1	P12109	334	352	341	341	Natural variant	ID=VAR_058221;Note=In BTHLM1. G->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15689448,ECO:0000269|PubMed:15955946;Dbxref=dbSNP:rs121912935,PMID:15689448,PMID:15955946
COL6A1	P12109	558	580	571	571	Natural variant	ID=VAR_058222;Note=In BTHLM1. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15689448;Dbxref=dbSNP:rs751040647,PMID:15689448
COL6A1	P12109	394	412	396	397	Sequence conflict	Note=QP->PA;Ontology_term=ECO:0000305;evidence=ECO:0000305
COL6A1	P12109	394	412	396	397	Sequence conflict	Note=QP->PA;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD5	Q8TDI0	1359	1390	1	1954	Chain	ID=PRO_0000080230;Note=Chromodomain-helicase-DNA-binding protein 5
CHD5	Q8TDI0	1359	1390	1390	1390	Modified residue	Note=N5-methylglutamine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26797129;Dbxref=PMID:26797129
CHD5	Q8TDI0	1359	1390	1390	1390	Mutagenesis	Note=Abolishes methylation by N6AMT1. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26797129;Dbxref=PMID:26797129
CHID1	Q9BWS9	320	346	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	234	267	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	203	233	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	320	346	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	234	267	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	203	233	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	320	346	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	234	267	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	203	233	20	393	Chain	ID=PRO_0000280608;Note=Chitinase domain-containing protein 1
CHID1	Q9BWS9	234	267	204	234	Alternative sequence	ID=VSP_023826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CHID1	Q9BWS9	203	233	204	234	Alternative sequence	ID=VSP_023826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CHID1	Q9BWS9	234	267	204	234	Alternative sequence	ID=VSP_023826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CHID1	Q9BWS9	203	233	204	234	Alternative sequence	ID=VSP_023826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CHID1	Q9BWS9	234	267	204	234	Alternative sequence	ID=VSP_023826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CHID1	Q9BWS9	203	233	204	234	Alternative sequence	ID=VSP_023826;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CHID1	Q9BWS9	320	346	331	331	Natural variant	ID=VAR_031173;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1127800,PMID:15489334
CHID1	Q9BWS9	320	346	331	331	Natural variant	ID=VAR_031173;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1127800,PMID:15489334
CHID1	Q9BWS9	320	346	331	331	Natural variant	ID=VAR_031173;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1127800,PMID:15489334
CHID1	Q9BWS9	320	346	338	338	Natural variant	ID=VAR_031174;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs6682,PMID:14702039,PMID:15489334
CHID1	Q9BWS9	320	346	338	338	Natural variant	ID=VAR_031174;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs6682,PMID:14702039,PMID:15489334
CHID1	Q9BWS9	320	346	338	338	Natural variant	ID=VAR_031174;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs6682,PMID:14702039,PMID:15489334
CHID1	Q9BWS9	234	267	261	261	Mutagenesis	Note=Significantly decreased carbohydrate binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20724479;Dbxref=PMID:20724479
CHID1	Q9BWS9	234	267	261	261	Mutagenesis	Note=Significantly decreased carbohydrate binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20724479;Dbxref=PMID:20724479
CHID1	Q9BWS9	234	267	261	261	Mutagenesis	Note=Significantly decreased carbohydrate binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20724479;Dbxref=PMID:20724479
CHID1	Q9BWS9	320	346	335	335	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHID1	Q9BWS9	320	346	335	335	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHID1	Q9BWS9	320	346	335	335	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHID1	Q9BWS9	203	233	202	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	202	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	202	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	222	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	222	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	222	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	203	233	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	243	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	243	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	243	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	254	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	254	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	234	267	254	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	318	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	318	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	318	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	333	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	333	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	333	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	336	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	336	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	336	339	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	340	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	340	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
CHID1	Q9BWS9	320	346	340	347	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BXW
TESC	Q96BS2	173	189	2	214	Chain	ID=PRO_0000073859;Note=Calcineurin B homologous protein 3
TESC	Q96BS2	43	69	2	214	Chain	ID=PRO_0000073859;Note=Calcineurin B homologous protein 3
TESC	Q96BS2	43	69	43	69	Alternative sequence	ID=VSP_045287;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TESC	Q96BS2	173	189	164	214	Alternative sequence	ID=VSP_035519;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC2A	Q6UVW9	18	46	1	174	Chain	ID=PRO_0000264240;Note=C-type lectin domain family 2 member A
CLEC2A	Q6UVW9	18	46	1	27	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC2A	Q6UVW9	18	46	28	48	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300A	Q9UGN4	222	258	18	299	Chain	ID=PRO_0000014682;Note=CMRF35-like molecule 8
CD300A	Q9UGN4	222	258	202	299	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300A	Q9UGN4	222	258	223	258	Alternative sequence	ID=VSP_041246;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
CLU	P10909	276	311	23	449	Chain	ID=PRO_0000005529;Note=Clusterin
CLU	P10909	82	139	23	449	Chain	ID=PRO_0000005529;Note=Clusterin
CLU	P10909	276	311	23	449	Chain	ID=PRO_0000005529;Note=Clusterin
CLU	P10909	82	139	23	449	Chain	ID=PRO_0000005529;Note=Clusterin
CLU	P10909	276	311	23	449	Chain	ID=PRO_0000005529;Note=Clusterin
CLU	P10909	82	139	23	449	Chain	ID=PRO_0000005529;Note=Clusterin
CLU	P10909	82	139	23	227	Chain	ID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
CLU	P10909	82	139	23	227	Chain	ID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
CLU	P10909	82	139	23	227	Chain	ID=PRO_0000005530;Note=Clusterin beta chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
CLU	P10909	276	311	228	449	Chain	ID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
CLU	P10909	276	311	228	449	Chain	ID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
CLU	P10909	276	311	228	449	Chain	ID=PRO_0000005531;Note=Clusterin alpha chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1974459;Dbxref=PMID:1974459
CLU	P10909	82	139	133	133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLU	P10909	82	139	133	133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLU	P10909	82	139	133	133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLU	P10909	82	139	86	86	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:19139490,PMID:19159218,PMID:9336835
CLU	P10909	82	139	86	86	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:19139490,PMID:19159218,PMID:9336835
CLU	P10909	82	139	86	86	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:19139490,PMID:19159218,PMID:9336835
CLU	P10909	82	139	103	103	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:19159218,PMID:2721499,PMID:9336835
CLU	P10909	82	139	103	103	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:19159218,PMID:2721499,PMID:9336835
CLU	P10909	82	139	103	103	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:19159218,PMID:2721499,PMID:9336835
CLU	P10909	276	311	291	291	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:18780401,PMID:2721499,PMID:9336835
CLU	P10909	276	311	291	291	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:18780401,PMID:2721499,PMID:9336835
CLU	P10909	276	311	291	291	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1551440,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:2721499,ECO:0000269|PubMed:9336835;Dbxref=PMID:1551440,PMID:16335952,PMID:18780401,PMID:2721499,PMID:9336835
CLU	P10909	276	311	102	313	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	102	313	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	102	313	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	102	313	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	102	313	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	102	313	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	113	305	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	113	305	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	113	305	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	113	305	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	113	305	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	113	305	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	116	302	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	116	302	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	116	302	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	116	302	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	116	302	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	116	302	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	121	295	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	121	295	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	121	295	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	121	295	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	121	295	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	121	295	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	129	285	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	129	285	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	129	285	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	129	285	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	276	311	129	285	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	129	285	Disulfide bond	Note=Interchain (between beta and alpha chains)
CLU	P10909	82	139	1	175	Alternative sequence	ID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLU	P10909	82	139	1	175	Alternative sequence	ID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLU	P10909	82	139	1	175	Alternative sequence	ID=VSP_041475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLU	P10909	276	311	305	305	Sequence conflict	Note=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLU	P10909	276	311	305	305	Sequence conflict	Note=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLU	P10909	276	311	305	305	Sequence conflict	Note=C->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNIH3	Q8TBE1	50	66	1	160	Chain	ID=PRO_0000122228;Note=Protein cornichon homolog 3
CNIH3	Q8TBE1	50	66	32	72	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNIH4	Q9P003	84	130	1	139	Chain	ID=PRO_0000122230;Note=Protein cornichon homolog 4
CNIH4	Q9P003	84	130	118	138	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNIH4	Q9P003	84	130	85	131	Alternative sequence	ID=VSP_013466;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:14702039;Dbxref=PMID:11230166,PMID:14702039
CNKSR1	Q969H4	208	228	1	720	Chain	ID=PRO_0000089969;Note=Connector enhancer of kinase suppressor of ras 1
CNKSR1	Q969H4	468	491	1	720	Chain	ID=PRO_0000089969;Note=Connector enhancer of kinase suppressor of ras 1
CNKSR1	Q969H4	208	228	196	285	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
CNKSR1	Q969H4	468	491	403	502	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
CNKSR3	Q6P9H4	243	266	1	555	Chain	ID=PRO_0000311105;Note=Connector enhancer of kinase suppressor of ras 3
CNKSR3	Q6P9H4	169	183	1	555	Chain	ID=PRO_0000311105;Note=Connector enhancer of kinase suppressor of ras 3
CNKSR3	Q6P9H4	169	183	80	174	Domain	Note=CRIC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00621
CNKSR3	Q6P9H4	243	266	211	293	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
CNKSR3	Q6P9H4	243	266	259	259	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTDNEP1	O95476	96	120	1	244	Chain	ID=PRO_0000297967;Note=CTD nuclear envelope phosphatase 1
CTDNEP1	O95476	96	120	1	244	Chain	ID=PRO_0000297967;Note=CTD nuclear envelope phosphatase 1
CTDNEP1	O95476	96	120	1	244	Chain	ID=PRO_0000297967;Note=CTD nuclear envelope phosphatase 1
CTDNEP1	O95476	96	120	57	224	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDNEP1	O95476	96	120	57	224	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDNEP1	O95476	96	120	57	224	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
NCAPD2	Q15021	571	651	1	1401	Chain	ID=PRO_0000095035;Note=Condensin complex subunit 1
NCAPD2	Q15021	1191	1217	1	1401	Chain	ID=PRO_0000095035;Note=Condensin complex subunit 1
NCAPD2	Q15021	571	651	1	603	Region	Note=Interactions with SMC2 and SMC4
NCAPD2	Q15021	571	651	585	585	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NCAPD2	Q15021	571	651	580	580	Natural variant	ID=VAR_057511;Note=K->R;Dbxref=dbSNP:rs17725914
C8B	P07358	368	411	55	591	Chain	ID=PRO_0000023592;Note=Complement component C8 beta chain
C8B	P07358	368	411	158	504	Domain	Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745
C8B	P07358	368	411	378	403	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21454577;Dbxref=PMID:21454577
C8B	P07358	368	411	366	369	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OJY
C8B	P07358	368	411	372	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OJY
C8B	P07358	368	411	379	381	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OJY
C8B	P07358	368	411	404	408	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OJY
C8B	P07358	368	411	409	412	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OJY
COL5A3	P25940	1468	1486	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	1330	1366	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	1312	1330	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	1276	1294	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	1204	1222	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	922	958	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	493	511	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	421	446	30	1745	Chain	ID=PRO_0000005845;Note=Collagen alpha-3(V) chain
COL5A3	P25940	421	446	391	440	Domain	Note=Collagen-like 1
COL5A3	P25940	493	511	482	538	Domain	Note=Collagen-like 2
COL5A3	P25940	922	958	905	950	Domain	Note=Collagen-like 4
COL5A3	P25940	922	958	951	989	Domain	Note=Collagen-like 5
COL5A3	P25940	1468	1486	1430	1488	Domain	Note=Collagen-like 6
COL5A3	P25940	1468	1486	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	1330	1366	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	1312	1330	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	1276	1294	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	1204	1222	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	922	958	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	493	511	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	421	446	392	1489	Region	Note=Triple-helical region
COL5A3	P25940	1204	1222	1207	1207	Natural variant	ID=VAR_020016;Note=R->P;Dbxref=dbSNP:rs2287813
CHP1	Q99653	137	178	2	195	Chain	ID=PRO_0000073843;Note=Calcineurin B homologous protein 1
CHP1	Q99653	137	178	110	145	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CHP1	Q99653	137	178	151	186	Domain	Note=EF-hand 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CHP1	Q99653	137	178	164	175	Calcium binding	Note=2
CHP1	Q99653	137	178	143	185	Region	Note=Necessary for nuclear export signal
CHP1	Q99653	137	178	138	147	Motif	Note=Nuclear export signal 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHP1	Q99653	137	178	176	185	Motif	Note=Nuclear export signal 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHP1	Q99653	137	178	143	143	Mutagenesis	Note=Inhibits translocation to the cytoplasm%3B when associated with A-145%3B A-147%3B A-183 and A-185. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20720019;Dbxref=PMID:20720019
CHP1	Q99653	137	178	145	145	Mutagenesis	Note=Inhibits translocation to the cytoplasm%3B when associated with A-143%3B A-147%3B A-183 and A-185. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20720019;Dbxref=PMID:20720019
CHP1	Q99653	137	178	147	147	Mutagenesis	Note=Inhibits translocation to the cytoplasm%3B when associated with A-143%3B A-145%3B A-183 and A-185. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20720019;Dbxref=PMID:20720019
CHP1	Q99653	137	178	175	175	Mutagenesis	Note=Reduces calcium-binding and SLC9A1-dependent Na(+)/H(+) exchange activity. Does not reduce colocalization and interaction with SLC9A1. Reduces colocalization and interaction with SLC9A1%3B when associated with A-134. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15035633;Dbxref=PMID:15035633
CHP1	Q99653	137	178	132	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E30
CHP1	Q99653	137	178	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E30
CHP1	Q99653	137	178	149	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E30
CHP1	Q99653	137	178	165	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E30
CHP1	Q99653	137	178	171	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E30
CHP1	Q99653	137	178	174	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E30
CLOCK	O15516	483	513	1	846	Chain	ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput
CLOCK	O15516	483	513	1	846	Chain	ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput
CLOCK	O15516	483	513	1	846	Chain	ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput
CLOCK	O15516	483	513	371	845	Region	Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785
CLOCK	O15516	483	513	371	845	Region	Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785
CLOCK	O15516	483	513	371	845	Region	Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785
CLOCK	O15516	483	513	450	570	Region	Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785
CLOCK	O15516	483	513	450	570	Region	Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785
CLOCK	O15516	483	513	450	570	Region	Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785
CD300LG	Q6UXG3	126	160	19	332	Chain	ID=PRO_0000306112;Note=CMRF35-like molecule 9
CD300LG	Q6UXG3	126	160	19	247	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300LG	Q6UXG3	126	160	137	137	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300LG	Q6UXG3	126	160	143	143	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300LG	Q6UXG3	126	160	144	144	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300LG	Q6UXG3	126	160	155	155	Glycosylation	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD300LG	Q6UXG3	126	160	127	211	Alternative sequence	ID=VSP_028410;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
CD300LG	Q6UXG3	126	160	127	161	Alternative sequence	ID=VSP_045362;Note=In isoform 5. GPCCPPSPSPTFQPLATTRLQPKAKAQQTQPPGLT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLMN	Q96JQ2	295	837	1	1002	Chain	ID=PRO_0000089854;Note=Calmin
CLMN	Q96JQ2	108	139	1	1002	Chain	ID=PRO_0000089854;Note=Calmin
CLMN	Q96JQ2	48	80	1	1002	Chain	ID=PRO_0000089854;Note=Calmin
CLMN	Q96JQ2	108	139	32	139	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CLMN	Q96JQ2	48	80	32	139	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CLMN	Q96JQ2	108	139	1	288	Region	Note=Actin-binding
CLMN	Q96JQ2	48	80	1	288	Region	Note=Actin-binding
CLMN	Q96JQ2	295	837	301	301	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLMN	Q96JQ2	295	837	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CLMN	Q96JQ2	295	837	619	619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLMN	Q96JQ2	295	837	699	699	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLMN	Q96JQ2	295	837	713	713	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLMN	Q96JQ2	295	837	769	769	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLMN	Q96JQ2	295	837	661	661	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLIP3	Q96DZ5	351	394	1	547	Chain	ID=PRO_0000076212;Note=CAP-Gly domain-containing linker protein 3
CLIP3	Q96DZ5	351	394	1	547	Chain	ID=PRO_0000076212;Note=CAP-Gly domain-containing linker protein 3
CLIP3	Q96DZ5	351	394	314	356	Domain	Note=CAP-Gly 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00045
CLIP3	Q96DZ5	351	394	314	356	Domain	Note=CAP-Gly 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00045
CLIP3	Q96DZ5	351	394	374	374	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9EHT4
CLIP3	Q96DZ5	351	394	374	374	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9EHT4
CLIP3	Q96DZ5	351	394	352	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CP0
CLIP3	Q96DZ5	351	394	352	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CP0
CLIP3	Q96DZ5	351	394	357	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CP0
CLIP3	Q96DZ5	351	394	357	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CP0
CLIP3	Q96DZ5	351	394	360	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CP0
CLIP3	Q96DZ5	351	394	360	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CP0
CLPB	Q9H078	550	590	37	707	Chain	ID=PRO_0000191239;Note=Caseinolytic peptidase B protein homolog
CLPB	Q9H078	404	419	37	707	Chain	ID=PRO_0000191239;Note=Caseinolytic peptidase B protein homolog
CLPB	Q9H078	359	385	37	707	Chain	ID=PRO_0000191239;Note=Caseinolytic peptidase B protein homolog
CLPB	Q9H078	215	245	37	707	Chain	ID=PRO_0000191239;Note=Caseinolytic peptidase B protein homolog
CLPB	Q9H078	152	180	37	707	Chain	ID=PRO_0000191239;Note=Caseinolytic peptidase B protein homolog
CLPB	Q9H078	152	180	133	162	Repeat	Note=ANK 1
CLPB	Q9H078	152	180	166	195	Repeat	Note=ANK 2
CLPB	Q9H078	359	385	381	388	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLPB	Q9H078	550	590	589	589	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CLPB	Q9H078	152	180	1	171	Alternative sequence	ID=VSP_057397;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLPB	Q9H078	152	180	152	180	Alternative sequence	ID=VSP_044726;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLPB	Q9H078	215	245	216	245	Alternative sequence	ID=VSP_001106;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLPB	Q9H078	404	419	408	408	Natural variant	ID=VAR_073399;Note=In MEGCANN%3B reduced ATPase activity in vitro. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25597510;Dbxref=dbSNP:rs144078282,PMID:25597510
CLPB	Q9H078	404	419	411	411	Natural variant	ID=VAR_073400;Note=In MEGCANN. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25597510;Dbxref=dbSNP:rs786205137,PMID:25597510
CLPB	Q9H078	550	590	567	567	Natural variant	ID=VAR_073404;Note=In MEGCANN. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25597510;Dbxref=dbSNP:rs150857620,PMID:25597510
CLPB	Q9H078	404	419	413	413	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLPB	Q9H078	550	590	563	563	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNNM3	Q8NE01	408	456	1	707	Chain	ID=PRO_0000295763;Note=Metal transporter CNNM3
CNNM3	Q8NE01	456	506	1	707	Chain	ID=PRO_0000295763;Note=Metal transporter CNNM3
CNNM3	Q8NE01	408	456	386	452	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CNNM3	Q8NE01	408	456	410	457	Alternative sequence	ID=VSP_027082;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CNNM3	Q8NE01	456	506	410	457	Alternative sequence	ID=VSP_027082;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CNNM3	Q8NE01	456	506	482	482	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNNM3	Q8NE01	408	456	412	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K23
CNNM3	Q8NE01	408	456	423	425	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K23
CNNM3	Q8NE01	408	456	428	436	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K23
CNNM3	Q8NE01	408	456	437	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K23
CNPY4	Q8N129	114	155	22	248	Chain	ID=PRO_0000314018;Note=Protein canopy homolog 4
CNPY4	Q8N129	114	155	140	229	Compositional bias	Note=Glu-rich
CNPY4	Q8N129	114	155	38	196	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNPY4	Q8N129	114	155	41	184	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CNPY4	Q8N129	114	155	94	156	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
COL4A5	P29400	27	47	27	1685	Chain	ID=PRO_0000005852;Note=Collagen alpha-5(IV) chain
COL4A5	P29400	155	182	27	1685	Chain	ID=PRO_0000005852;Note=Collagen alpha-5(IV) chain
COL4A5	P29400	182	203	27	1685	Chain	ID=PRO_0000005852;Note=Collagen alpha-5(IV) chain
COL4A5	P29400	892	922	27	1685	Chain	ID=PRO_0000005852;Note=Collagen alpha-5(IV) chain
COL4A5	P29400	27	47	27	41	Region	Note=Nonhelical region (NC2)
COL4A5	P29400	27	47	42	1456	Region	Note=Triple-helical region
COL4A5	P29400	155	182	42	1456	Region	Note=Triple-helical region
COL4A5	P29400	182	203	42	1456	Region	Note=Triple-helical region
COL4A5	P29400	892	922	42	1456	Region	Note=Triple-helical region
COL4A5	P29400	155	182	174	174	Natural variant	ID=VAR_001917;Note=In APSX. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452056;Dbxref=dbSNP:rs104886055,PMID:9452056
COL4A5	P29400	155	182	177	177	Natural variant	ID=VAR_011220;Note=In APSX%3B presenting with dot-and-fleck retinopathy. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11004279;Dbxref=dbSNP:rs104886056,PMID:11004279
COL4A5	P29400	155	182	177	177	Natural variant	ID=VAR_001918;Note=In APSX%3B adult type. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452056;Dbxref=dbSNP:rs104886056,PMID:9452056
COL4A5	P29400	182	203	192	192	Natural variant	ID=VAR_011221;Note=In APSX. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11223851;Dbxref=dbSNP:rs104886060,PMID:11223851
COL4A5	P29400	892	922	898	898	Natural variant	ID=VAR_011258;Note=In APSX%3B mild phenotype. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11223851;Dbxref=dbSNP:rs104886192,PMID:11223851
COL4A5	P29400	892	922	902	902	Natural variant	ID=VAR_011259;Note=In APSX%3B juvenile type. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10684360;Dbxref=PMID:10684360
COL4A5	P29400	892	922	911	911	Natural variant	ID=VAR_011260;Note=In APSX. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10684360;Dbxref=dbSNP:rs104886363,PMID:10684360
CNOT2	Q9NZN8	16	57	1	540	Chain	ID=PRO_0000198331;Note=CCR4-NOT transcription complex subunit 2
CNOT2	Q9NZN8	129	189	1	540	Chain	ID=PRO_0000198331;Note=CCR4-NOT transcription complex subunit 2
CNOT2	Q9NZN8	16	57	1	540	Chain	ID=PRO_0000198331;Note=CCR4-NOT transcription complex subunit 2
CNOT2	Q9NZN8	129	189	1	540	Chain	ID=PRO_0000198331;Note=CCR4-NOT transcription complex subunit 2
CNOT2	Q9NZN8	129	189	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5L3
CNOT2	Q9NZN8	129	189	157	157	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5L3
CNOT2	Q9NZN8	129	189	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
CNOT2	Q9NZN8	129	189	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
CNOT2	Q9NZN8	129	189	169	169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5L3
CNOT2	Q9NZN8	129	189	169	169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C5L3
CNOT2	Q9NZN8	16	57	1	349	Alternative sequence	ID=VSP_009913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CNOT2	Q9NZN8	129	189	1	349	Alternative sequence	ID=VSP_009913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CNOT2	Q9NZN8	16	57	1	349	Alternative sequence	ID=VSP_009913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CNOT2	Q9NZN8	129	189	1	349	Alternative sequence	ID=VSP_009913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CNOT2	Q9NZN8	16	57	1	175	Alternative sequence	ID=VSP_009912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CNOT2	Q9NZN8	129	189	1	175	Alternative sequence	ID=VSP_009912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CNOT2	Q9NZN8	16	57	1	175	Alternative sequence	ID=VSP_009912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CNOT2	Q9NZN8	129	189	1	175	Alternative sequence	ID=VSP_009912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DGKE	P52429	366	404	1	567	Chain	ID=PRO_0000218464;Note=Diacylglycerol kinase epsilon
DGKE	P52429	404	428	1	567	Chain	ID=PRO_0000218464;Note=Diacylglycerol kinase epsilon
DGKE	P52429	366	404	178	567	Alternative sequence	ID=VSP_056958;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DGKE	P52429	404	428	178	567	Alternative sequence	ID=VSP_056958;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DGKG	P49619	450	474	1	791	Chain	ID=PRO_0000218459;Note=Diacylglycerol kinase gamma
DGKG	P49619	403	423	1	791	Chain	ID=PRO_0000218459;Note=Diacylglycerol kinase gamma
DGKG	P49619	333	372	1	791	Chain	ID=PRO_0000218459;Note=Diacylglycerol kinase gamma
DGKG	P49619	223	264	1	791	Chain	ID=PRO_0000218459;Note=Diacylglycerol kinase gamma
DGKG	P49619	223	264	220	255	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
DGKG	P49619	450	474	430	564	Domain	Note=DAGKc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00783
DGKG	P49619	223	264	233	244	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
DGKG	P49619	333	372	336	385	Zinc finger	Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
DGKG	P49619	333	372	334	372	Alternative sequence	ID=VSP_039922;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DGKG	P49619	450	474	451	475	Alternative sequence	ID=VSP_001267;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DGKG	P49619	333	372	370	370	Natural variant	ID=VAR_020260;Note=R->W;Dbxref=dbSNP:rs3213770
DGKQ	P52824	772	820	1	942	Chain	ID=PRO_0000218467;Note=Diacylglycerol kinase theta
DGKQ	P52824	526	539	1	942	Chain	ID=PRO_0000218467;Note=Diacylglycerol kinase theta
COL22A1	Q8NFW1	1395	1455	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	1290	1308	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	1257	1275	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	1111	1149	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	1004	1024	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	936	954	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	800	821	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	749	767	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	713	731	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	695	713	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	519	532	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	483	498	28	1626	Chain	ID=PRO_0000317615;Note=Collagen alpha-1(XXII) chain
COL22A1	Q8NFW1	519	532	481	520	Domain	Note=Collagen-like 1
COL22A1	Q8NFW1	483	498	481	520	Domain	Note=Collagen-like 1
COL22A1	Q8NFW1	519	532	526	565	Domain	Note=Collagen-like 2
COL22A1	Q8NFW1	695	713	657	708	Domain	Note=Collagen-like 4
COL22A1	Q8NFW1	749	767	714	773	Domain	Note=Collagen-like 5
COL22A1	Q8NFW1	713	731	714	773	Domain	Note=Collagen-like 5
COL22A1	Q8NFW1	800	821	774	833	Domain	Note=Collagen-like 6
COL22A1	Q8NFW1	936	954	925	984	Domain	Note=Collagen-like 8
COL22A1	Q8NFW1	1111	1149	1118	1155	Domain	Note=Collagen-like 10
COL22A1	Q8NFW1	1290	1308	1249	1308	Domain	Note=Collagen-like 12
COL22A1	Q8NFW1	1257	1275	1249	1308	Domain	Note=Collagen-like 12
COL22A1	Q8NFW1	1395	1455	1387	1446	Domain	Note=Collagen-like 14
COL22A1	Q8NFW1	1395	1455	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	1290	1308	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	1257	1275	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	1111	1149	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	1004	1024	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	936	954	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	800	821	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	749	767	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	713	731	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	695	713	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	519	532	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	483	498	451	1607	Compositional bias	Note=Pro-rich
COL22A1	Q8NFW1	1395	1455	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	1290	1308	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	1257	1275	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	1111	1149	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	1004	1024	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	936	954	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	800	821	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	749	767	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	713	731	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	695	713	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	519	532	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	483	498	481	1603	Compositional bias	Note=Gly-rich
COL22A1	Q8NFW1	519	532	341	627	Alternative sequence	ID=VSP_038200;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL22A1	Q8NFW1	483	498	341	627	Alternative sequence	ID=VSP_038200;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL22A1	Q8NFW1	1004	1024	1005	1024	Alternative sequence	ID=VSP_031087;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL22A1	Q8NFW1	695	713	703	703	Natural variant	ID=VAR_038563;Note=P->T;Dbxref=dbSNP:rs10111520
COL22A1	Q8NFW1	936	954	938	938	Natural variant	ID=VAR_038564;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs4909444,PMID:15489334
COL22A1	Q8NFW1	749	767	753	767	Sequence conflict	Note=GKDGPNGPPGPPGTK->CILAAKTAPGLKQLN;Ontology_term=ECO:0000305;evidence=ECO:0000305
COPA	P53621	825	855	1	1224	Chain	ID=PRO_0000223307;Note=Coatomer subunit alpha
COPA	P53621	610	659	1	1224	Chain	ID=PRO_0000223307;Note=Coatomer subunit alpha
COL27A1	Q8IZC6	636	654	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	672	690	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	708	723	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	723	741	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	774	789	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	807	822	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	840	855	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	873	891	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	927	945	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	993	1011	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1083	1098	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1098	1113	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1149	1167	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1167	1185	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1203	1239	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1366	1384	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1384	1402	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1456	1492	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1528	1546	625	1621	Chain	ID=PRO_5000089163;Note=Collagen alpha-1(XXVII) chain
COL27A1	Q8IZC6	1624	1646	1622	1860	Propeptide	ID=PRO_0000314668;Note=C-terminal propeptide
COL27A1	Q8IZC6	636	654	625	679	Domain	Note=Collagen-like 1
COL27A1	Q8IZC6	672	690	625	679	Domain	Note=Collagen-like 1
COL27A1	Q8IZC6	672	690	688	747	Domain	Note=Collagen-like 2
COL27A1	Q8IZC6	708	723	688	747	Domain	Note=Collagen-like 2
COL27A1	Q8IZC6	723	741	688	747	Domain	Note=Collagen-like 2
COL27A1	Q8IZC6	774	789	748	807	Domain	Note=Collagen-like 3
COL27A1	Q8IZC6	807	822	748	807	Domain	Note=Collagen-like 3
COL27A1	Q8IZC6	807	822	808	867	Domain	Note=Collagen-like 4
COL27A1	Q8IZC6	840	855	808	867	Domain	Note=Collagen-like 4
COL27A1	Q8IZC6	873	891	871	930	Domain	Note=Collagen-like 5
COL27A1	Q8IZC6	927	945	871	930	Domain	Note=Collagen-like 5
COL27A1	Q8IZC6	927	945	931	990	Domain	Note=Collagen-like 6
COL27A1	Q8IZC6	993	1011	1003	1062	Domain	Note=Collagen-like 7
COL27A1	Q8IZC6	1083	1098	1066	1125	Domain	Note=Collagen-like 8
COL27A1	Q8IZC6	1098	1113	1066	1125	Domain	Note=Collagen-like 8
COL27A1	Q8IZC6	1149	1167	1126	1185	Domain	Note=Collagen-like 9
COL27A1	Q8IZC6	1167	1185	1126	1185	Domain	Note=Collagen-like 9
COL27A1	Q8IZC6	1203	1239	1192	1251	Domain	Note=Collagen-like 10
COL27A1	Q8IZC6	1366	1384	1318	1378	Domain	Note=Collagen-like 12
COL27A1	Q8IZC6	1366	1384	1382	1441	Domain	Note=Collagen-like 13
COL27A1	Q8IZC6	1384	1402	1382	1441	Domain	Note=Collagen-like 13
COL27A1	Q8IZC6	1456	1492	1442	1501	Domain	Note=Collagen-like 14
COL27A1	Q8IZC6	1528	1546	1502	1561	Domain	Note=Collagen-like 15
COL27A1	Q8IZC6	636	654	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	672	690	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	708	723	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	723	741	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	774	789	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	807	822	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	840	855	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	873	891	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	927	945	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	993	1011	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1083	1098	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1098	1113	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1149	1167	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1167	1185	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1203	1239	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1366	1384	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1384	1402	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1456	1492	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	1528	1546	625	1618	Region	Note=Triple-helical region
COL27A1	Q8IZC6	636	654	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	672	690	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	708	723	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	723	741	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	774	789	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	807	822	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	840	855	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	873	891	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	927	945	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	993	1011	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1083	1098	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1098	1113	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1149	1167	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1167	1185	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1203	1239	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1366	1384	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1384	1402	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1456	1492	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	1528	1546	283	1621	Compositional bias	Note=Pro-rich
COL27A1	Q8IZC6	636	654	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	672	690	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	708	723	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	723	741	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	774	789	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	807	822	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	840	855	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	873	891	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	927	945	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	993	1011	1	1033	Alternative sequence	ID=VSP_030347;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
COL27A1	Q8IZC6	636	654	637	703	Alternative sequence	ID=VSP_030348;Note=In isoform 3. GPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPG->VRLSGVCMLLGAPVGDWGIGQVVAPSKDRKRSSLEQGAGYGYILGSSQAPGSSGSAKCIIAHPAPDS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	672	690	637	703	Alternative sequence	ID=VSP_030348;Note=In isoform 3. GPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPG->VRLSGVCMLLGAPVGDWGIGQVVAPSKDRKRSSLEQGAGYGYILGSSQAPGSSGSAKCIIAHPAPDS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	708	723	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	723	741	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	774	789	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	807	822	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	840	855	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	873	891	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	927	945	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	993	1011	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1083	1098	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1098	1113	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1149	1167	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1167	1185	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1203	1239	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1366	1384	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1384	1402	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1456	1492	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1528	1546	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	1624	1646	704	1860	Alternative sequence	ID=VSP_030349;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
COL27A1	Q8IZC6	708	723	720	720	Natural variant	ID=VAR_048791;Note=P->R;Dbxref=dbSNP:rs35446342
DDX60L	Q5H9U9	1643	1663	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	1372	1407	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	838	870	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	748	798	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	379	431	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	838	870	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	748	798	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	379	431	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	1643	1663	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	1372	1407	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	838	870	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	748	798	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	379	431	1	1706	Chain	ID=PRO_0000318155;Note=Probable ATP-dependent RNA helicase DDX60-like
DDX60L	Q5H9U9	838	870	752	919	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	748	798	752	919	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	838	870	752	919	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	748	798	752	919	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	838	870	752	919	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	748	798	752	919	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	748	798	765	772	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	748	798	765	772	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	748	798	765	772	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60L	Q5H9U9	838	870	869	872	Motif	Note=DEAH box
DDX60L	Q5H9U9	838	870	869	872	Motif	Note=DEAH box
DDX60L	Q5H9U9	838	870	869	872	Motif	Note=DEAH box
DDX60L	Q5H9U9	1643	1663	1308	1706	Alternative sequence	ID=VSP_040822;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
DDX60L	Q5H9U9	1372	1407	1308	1706	Alternative sequence	ID=VSP_040822;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
DDX60L	Q5H9U9	1643	1663	1308	1706	Alternative sequence	ID=VSP_040822;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
DDX60L	Q5H9U9	1372	1407	1308	1706	Alternative sequence	ID=VSP_040822;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
DDX60L	Q5H9U9	379	431	409	409	Natural variant	ID=VAR_055899;Note=V->L;Dbxref=dbSNP:rs13151700
DDX60L	Q5H9U9	379	431	409	409	Natural variant	ID=VAR_055899;Note=V->L;Dbxref=dbSNP:rs13151700
DDX60L	Q5H9U9	379	431	409	409	Natural variant	ID=VAR_055899;Note=V->L;Dbxref=dbSNP:rs13151700
DDX60L	Q5H9U9	1643	1663	1646	1646	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX60L	Q5H9U9	1643	1663	1646	1646	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHPF2	Q9P2E5	276	337	1	772	Chain	ID=PRO_0000189563;Note=Chondroitin sulfate glucuronyltransferase
CHPF2	Q9P2E5	276	337	30	772	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHKA	P35790	172	210	1	457	Chain	ID=PRO_0000206219;Note=Choline kinase alpha
CHKA	P35790	154	172	1	457	Chain	ID=PRO_0000206219;Note=Choline kinase alpha
CHKA	P35790	172	210	207	213	Nucleotide binding	Note=ATP
CHKA	P35790	172	210	155	172	Alternative sequence	ID=VSP_009683;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHKA	P35790	154	172	155	172	Alternative sequence	ID=VSP_009683;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CHKA	P35790	154	172	154	154	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHKA	P35790	172	210	176	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTG
CHKA	P35790	172	210	196	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTG
CHKA	P35790	172	210	203	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FTG
CLTA	P09496	162	179	1	248	Chain	ID=PRO_0000205767;Note=Clathrin light chain A
CLTA	P09496	180	191	1	248	Chain	ID=PRO_0000205767;Note=Clathrin light chain A
CLTA	P09496	162	179	1	248	Chain	ID=PRO_0000205767;Note=Clathrin light chain A
CLTA	P09496	162	179	100	162	Region	Note=Involved in binding clathrin heavy chain
CLTA	P09496	162	179	100	162	Region	Note=Involved in binding clathrin heavy chain
CLTA	P09496	162	179	162	180	Alternative sequence	ID=VSP_043239;Note=In isoform 4. RVADEAFYKQPFADVIGYV->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLTA	P09496	180	191	162	180	Alternative sequence	ID=VSP_043239;Note=In isoform 4. RVADEAFYKQPFADVIGYV->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLTA	P09496	162	179	162	180	Alternative sequence	ID=VSP_043239;Note=In isoform 4. RVADEAFYKQPFADVIGYV->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLTA	P09496	162	179	163	192	Alternative sequence	ID=VSP_001095;Note=In isoform Non-brain and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3267234,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334,PMID:3267234
CLTA	P09496	180	191	163	192	Alternative sequence	ID=VSP_001095;Note=In isoform Non-brain and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3267234,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334,PMID:3267234
CLTA	P09496	162	179	163	192	Alternative sequence	ID=VSP_001095;Note=In isoform Non-brain and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3267234,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334,PMID:3267234
CLTA	P09496	180	191	181	192	Alternative sequence	ID=VSP_024238;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DENR	O43583	98	137	2	198	Chain	ID=PRO_0000130600;Note=Density-regulated protein
DENR	O43583	98	137	115	182	Domain	Note=SUI1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00200
CLDN16	Q9Y5I7	197	261	1	305	Chain	ID=PRO_0000144774;Note=Claudin-16
CLDN16	Q9Y5I7	197	261	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN16	Q9Y5I7	197	261	207	239	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN16	Q9Y5I7	197	261	240	260	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN16	Q9Y5I7	197	261	261	305	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN16	Q9Y5I7	197	261	198	198	Natural variant	ID=VAR_017234;Note=In HOMG3. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11518780;Dbxref=PMID:11518780
CLDN16	Q9Y5I7	197	261	198	198	Natural variant	ID=VAR_008176;Note=In HOMG3. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10390358,ECO:0000269|PubMed:10878661;Dbxref=dbSNP:rs104893723,PMID:10390358,PMID:10878661
CLDN16	Q9Y5I7	197	261	209	209	Natural variant	ID=VAR_017235;Note=In HOMG3. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11518780;Dbxref=PMID:11518780
CLDN16	Q9Y5I7	197	261	216	216	Natural variant	ID=VAR_017236;Note=In HOMG3. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11518780;Dbxref=PMID:11518780
CLDN16	Q9Y5I7	197	261	232	232	Natural variant	ID=VAR_008177;Note=In HOMG3. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10390358;Dbxref=dbSNP:rs104893726,PMID:10390358
CLDN16	Q9Y5I7	197	261	233	233	Natural variant	ID=VAR_008178;Note=In HOMG3. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10390358;Dbxref=dbSNP:rs104893727,PMID:10390358
CLDN16	Q9Y5I7	197	261	235	235	Natural variant	ID=VAR_008179;Note=In HOMG3. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10390358;Dbxref=dbSNP:rs104893728,PMID:10390358
CLDN16	Q9Y5I7	197	261	235	235	Natural variant	ID=VAR_017237;Note=In HOMG3. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11518780;Dbxref=PMID:11518780
CLDN16	Q9Y5I7	197	261	239	239	Natural variant	ID=VAR_008172;Note=In HOMG3. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10390358,ECO:0000269|PubMed:10878661,ECO:0000269|PubMed:11518780;Dbxref=dbSNP:rs104893721,PMID:10390358,PMID:10878661,PMID:11518780
CLCN4	P51793	144	185	1	760	Chain	ID=PRO_0000094443;Note=H(+)/Cl(-) exchange transporter 4
CLCN4	P51793	144	185	151	174	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN4	P51793	144	185	183	190	Intramembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN4	P51793	144	185	180	184	Motif	Note=Selectivity filter part_1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN4	P51793	144	185	181	181	Binding site	Note=Chloride;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN4	P51793	144	185	178	178	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLCNKA	P51800	76	119	1	687	Chain	ID=PRO_0000094455;Note=Chloride channel protein ClC-Ka
CLCNKA	P51800	643	672	1	687	Chain	ID=PRO_0000094455;Note=Chloride channel protein ClC-Ka
CLCNKA	P51800	643	672	507	687	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLCNKA	P51800	643	672	626	684	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCNKA	P51800	76	119	77	119	Alternative sequence	ID=VSP_044700;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLCNKA	P51800	76	119	80	80	Natural variant	ID=VAR_063074;Note=In BARTS4B%3B a patient also carrying a mutation in CLCNKB. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15044642;Dbxref=dbSNP:rs121909137,PMID:15044642
CLCNKA	P51800	76	119	83	83	Natural variant	ID=VAR_019787;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs10927887
CLCNKA	P51800	643	672	641	650	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PFI
CLCNKA	P51800	643	672	654	660	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PFI
CLCNKA	P51800	643	672	663	669	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PFI
CLCNKA	P51800	643	672	670	681	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PFI
CLEC18B	Q6UXF7	261	292	27	455	Chain	ID=PRO_0000324315;Note=C-type lectin domain family 18 member B
CLEC18B	Q6UXF7	72	152	27	455	Chain	ID=PRO_0000324315;Note=C-type lectin domain family 18 member B
CLEC18B	Q6UXF7	72	152	52	182	Domain	Note=SCP
CLEC18B	Q6UXF7	261	292	228	261	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CLEC18B	Q6UXF7	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18B	Q6UXF7	72	152	73	152	Alternative sequence	ID=VSP_037307;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC18B	Q6UXF7	261	292	261	261	Alternative sequence	ID=VSP_037308;Note=In isoform 2. Q->QGHLPNSNMPHSAMGTKPKTPGVPAIGSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLCN7	P51798	750	777	1	805	Chain	ID=PRO_0000094452;Note=H(+)/Cl(-) exchange transporter 7
CLCN7	P51798	327	366	1	805	Chain	ID=PRO_0000094452;Note=H(+)/Cl(-) exchange transporter 7
CLCN7	P51798	225	246	1	805	Chain	ID=PRO_0000094452;Note=H(+)/Cl(-) exchange transporter 7
CLCN7	P51798	47	71	1	805	Chain	ID=PRO_0000094452;Note=H(+)/Cl(-) exchange transporter 7
CLCN7	P51798	47	71	1	126	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN7	P51798	225	246	223	241	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN7	P51798	327	366	322	341	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN7	P51798	750	777	598	805	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN7	P51798	750	777	741	799	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCN7	P51798	225	246	245	249	Motif	Note=Selectivity filter part_2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN7	P51798	47	71	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CLCN7	P51798	47	71	48	71	Alternative sequence	ID=VSP_045698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLCN7	P51798	225	246	227	227	Natural variant	ID=VAR_064639;Note=In OPTB4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953639;Dbxref=PMID:19953639
CLCN7	P51798	225	246	240	240	Natural variant	ID=VAR_020998;Note=In OPTB4. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14584882,ECO:0000269|PubMed:19953639;Dbxref=PMID:14584882,PMID:19953639
CLCN7	P51798	327	366	332	332	Natural variant	ID=VAR_021001;Note=In OPTB4. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14584882;Dbxref=PMID:14584882
CLCN7	P51798	327	366	347	347	Natural variant	ID=VAR_075582;Note=In OPTA2%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26395888;Dbxref=PMID:26395888
CLCN7	P51798	750	777	758	758	Natural variant	ID=VAR_064646;Note=In OPTA2. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953639;Dbxref=dbSNP:rs760740877,PMID:19953639
CLCN7	P51798	750	777	762	762	Natural variant	ID=VAR_017838;Note=In OPTA2 and OPTB4%3B not detected in the fibroblasts from the patient. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11207362,ECO:0000269|PubMed:19953639;Dbxref=dbSNP:rs121434433,PMID:11207362,PMID:19953639
CLCN7	P51798	750	777	762	762	Natural variant	ID=VAR_064647;Note=In OPTB4. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953639;Dbxref=PMID:19953639
CLCN7	P51798	750	777	766	766	Natural variant	ID=VAR_017839;Note=In OPTB4. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11741829;Dbxref=dbSNP:rs121434434,PMID:11741829
CLCN7	P51798	750	777	767	767	Natural variant	ID=VAR_064648;Note=In OPTB4. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953639;Dbxref=PMID:19953639
CLCN7	P51798	750	777	767	767	Natural variant	ID=VAR_021008;Note=In OPTB4. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14584882;Dbxref=dbSNP:rs772579858,PMID:14584882
CLCN7	P51798	750	777	767	767	Natural variant	ID=VAR_017840;Note=In OPTA2 and OPTB4. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11741829,ECO:0000269|PubMed:14584882,ECO:0000269|PubMed:19288050,ECO:0000269|PubMed:19953639;Dbxref=dbSNP:rs121434435,PMID:11741829,PMID:14584882,PMID:19288050,PMID:19953639
CLCN7	P51798	327	366	348	348	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLPTM1L	Q96KA5	457	472	1	538	Chain	ID=PRO_0000331300;Note=Cleft lip and palate transmembrane protein 1-like protein
CLPTM1L	Q96KA5	382	399	1	538	Chain	ID=PRO_0000331300;Note=Cleft lip and palate transmembrane protein 1-like protein
CLPTM1L	Q96KA5	382	399	365	402	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLPTM1L	Q96KA5	457	472	450	538	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSPN	Q9HAW4	526	590	1	1339	Chain	ID=PRO_0000089875;Note=Claspin
CLSPN	Q9HAW4	194	248	1	1339	Chain	ID=PRO_0000089875;Note=Claspin
CLSPN	Q9HAW4	194	248	162	196	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLSPN	Q9HAW4	194	248	225	225	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
CLSPN	Q9HAW4	526	590	527	590	Alternative sequence	ID=VSP_036033;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLYBL	Q8N0X4	146	180	23	340	Chain	ID=PRO_0000286389;Note=Citramalyl-CoA lyase%2C mitochondrial
CLYBL	Q8N0X4	146	180	171	171	Metal binding	Note=Magnesium;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5VXC,ECO:0000269|PubMed:29056341;Dbxref=PMID:29056341
CLYBL	Q8N0X4	146	180	147	180	Alternative sequence	ID=VSP_034643;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLYBL	Q8N0X4	146	180	141	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VXC
CLYBL	Q8N0X4	146	180	155	157	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VXC
CLYBL	Q8N0X4	146	180	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VXC
CLYBL	Q8N0X4	146	180	173	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VXC
CLYBL	Q8N0X4	146	180	179	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VXC
NCAPG	Q9BPX3	323	372	1	1015	Chain	ID=PRO_0000095041;Note=Condensin complex subunit 3
NCAPG	Q9BPX3	628	703	1	1015	Chain	ID=PRO_0000095041;Note=Condensin complex subunit 3
NCAPG	Q9BPX3	922	951	1	1015	Chain	ID=PRO_0000095041;Note=Condensin complex subunit 3
NCAPG	Q9BPX3	628	703	617	654	Repeat	Note=HEAT 8
NCAPG	Q9BPX3	628	703	687	724	Repeat	Note=HEAT 9
NCAPG	Q9BPX3	628	703	674	674	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
NCAPG	Q9BPX3	922	951	931	931	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
NCAPG	Q9BPX3	628	703	676	676	Sequence conflict	Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCAPG	Q9BPX3	628	703	681	681	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCAPD3	P42695	1034	1079	1	1498	Chain	ID=PRO_0000050716;Note=Condensin-2 complex subunit D3
NCAPD3	P42695	563	608	1	1498	Chain	ID=PRO_0000050716;Note=Condensin-2 complex subunit D3
NCAPD3	P42695	563	608	537	572	Repeat	Note=HEAT 2
NCAPD3	P42695	563	608	579	610	Repeat	Note=HEAT 3
NCAPD3	P42695	563	608	567	567	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
NCAPD3	P42695	1034	1079	1034	1034	Natural variant	ID=VAR_053045;Note=S->R;Dbxref=dbSNP:rs7927108
CNGB1	Q14028	739	768	1	1251	Chain	ID=PRO_0000219323;Note=Cyclic nucleotide-gated cation channel beta-1
CNGB1	Q14028	739	768	734	753	Transmembrane	Note=Helical%3B Name%3DH3;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGB1	Q14028	739	768	754	790	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNGB1	Q14028	739	768	300	1251	Alternative sequence	ID=VSP_037922;Note=In isoform GARP2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7590744;Dbxref=PMID:7590744
CNGB1	Q14028	739	768	745	745	Natural variant	ID=VAR_059228;Note=L->I;Dbxref=dbSNP:rs10459809
CNN2	Q99439	84	130	2	309	Chain	ID=PRO_0000204773;Note=Calponin-2
CNN2	Q99439	130	169	2	309	Chain	ID=PRO_0000204773;Note=Calponin-2
CNN2	Q99439	84	130	28	132	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CNN2	Q99439	130	169	28	132	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CNN2	Q99439	130	169	166	191	Repeat	Note=Calponin-like 1
CNN2	Q99439	130	169	138	138	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CNN2	Q99439	130	169	131	169	Alternative sequence	ID=VSP_042941;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CNN2	Q99439	130	169	142	142	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNN2	Q99439	130	169	165	165	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNN2	Q99439	84	130	81	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYN
CNN2	Q99439	84	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYN
CNN2	Q99439	84	130	108	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYN
CNN2	Q99439	84	130	118	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYN
CNN2	Q99439	130	169	118	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYN
CNN2	Q99439	130	169	132	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WYN
CNIH1	O95406	88	135	1	144	Chain	ID=PRO_0000122222;Note=Protein cornichon homolog 1
CNIH1	O95406	27	50	1	144	Chain	ID=PRO_0000122222;Note=Protein cornichon homolog 1
CNIH1	O95406	27	50	11	31	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNIH1	O95406	27	50	32	56	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNIH1	O95406	88	135	78	122	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNIH1	O95406	88	135	123	143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTFR	P26992	0	28	1	22	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTFR	P26992	28	106	23	342	Chain	ID=PRO_0000010991;Note=Ciliary neurotrophic factor receptor subunit alpha
CNTFR	P26992	28	106	23	342	Chain	ID=PRO_0000010991;Note=Ciliary neurotrophic factor receptor subunit alpha
CNTFR	P26992	0	28	23	342	Chain	ID=PRO_0000010991;Note=Ciliary neurotrophic factor receptor subunit alpha
CNTFR	P26992	28	106	27	104	Domain	Note=Ig-like C2-type
CNTFR	P26992	28	106	27	104	Domain	Note=Ig-like C2-type
CNTFR	P26992	0	28	27	104	Domain	Note=Ig-like C2-type
CNTFR	P26992	28	106	60	60	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTFR	P26992	28	106	60	60	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTFR	P26992	28	106	70	70	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTFR	P26992	28	106	70	70	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNTFR	P26992	28	106	46	89	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CNTFR	P26992	28	106	46	89	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
C9orf85	Q96MD7	70	107	2	179	Chain	ID=PRO_0000089720;Note=Uncharacterized protein C9orf85
C9orf85	Q96MD7	70	107	23	79	Compositional bias	Note=Lys-rich
C9orf85	Q96MD7	70	107	36	179	Alternative sequence	ID=VSP_014429;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CS	O75390	133	196	28	466	Chain	ID=PRO_0000005471;Note=Citrate synthase%2C mitochondrial
CS	O75390	67	89	28	466	Chain	ID=PRO_0000005471;Note=Citrate synthase%2C mitochondrial
CS	O75390	31	67	28	466	Chain	ID=PRO_0000005471;Note=Citrate synthase%2C mitochondrial
CS	O75390	31	67	57	57	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CZU6
CS	O75390	67	89	76	76	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q29RK1
CS	O75390	67	89	76	76	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q29RK1
CS	O75390	133	196	193	193	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CZU6
CS	O75390	31	67	55	55	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CS	O75390	133	196	183	183	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
CS	O75390	133	196	187	187	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CS	O75390	31	67	33	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	31	67	59	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	67	89	65	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	31	67	65	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	67	89	70	74	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	67	89	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	67	89	82	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	67	89	87	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	131	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	149	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	164	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	175	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	180	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
CS	O75390	133	196	194	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UZP
C11orf54	Q9H0W9	18	51	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	110	169	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	169	219	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	18	51	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	110	169	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	169	219	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	18	51	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	110	169	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	169	219	1	315	Chain	ID=PRO_0000246029;Note=Ester hydrolase C11orf54
C11orf54	Q9H0W9	18	51	1	111	Alternative sequence	ID=VSP_019817;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
C11orf54	Q9H0W9	110	169	1	111	Alternative sequence	ID=VSP_019817;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
C11orf54	Q9H0W9	18	51	1	111	Alternative sequence	ID=VSP_019817;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
C11orf54	Q9H0W9	110	169	1	111	Alternative sequence	ID=VSP_019817;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
C11orf54	Q9H0W9	18	51	1	111	Alternative sequence	ID=VSP_019817;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
C11orf54	Q9H0W9	110	169	1	111	Alternative sequence	ID=VSP_019817;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
C11orf54	Q9H0W9	18	51	1	19	Alternative sequence	ID=VSP_019818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C11orf54	Q9H0W9	18	51	1	19	Alternative sequence	ID=VSP_019818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C11orf54	Q9H0W9	18	51	1	19	Alternative sequence	ID=VSP_019818;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C11orf54	Q9H0W9	169	219	170	219	Alternative sequence	ID=VSP_019821;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C11orf54	Q9H0W9	169	219	170	219	Alternative sequence	ID=VSP_019821;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C11orf54	Q9H0W9	169	219	170	219	Alternative sequence	ID=VSP_019821;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C11orf54	Q9H0W9	169	219	184	184	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf54	Q9H0W9	169	219	184	184	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf54	Q9H0W9	169	219	184	184	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf54	Q9H0W9	18	51	13	27	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	13	27	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	13	27	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	28	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	28	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	28	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	44	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	44	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	44	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	18	51	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	114	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	114	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	114	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	129	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	129	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	129	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	135	137	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	135	137	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	135	137	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	140	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	145	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	145	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	145	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	153	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	153	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	153	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	169	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	169	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	169	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	169	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	110	169	169	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	169	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	184	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	184	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	184	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	202	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	202	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
C11orf54	Q9H0W9	169	219	202	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XCR
CLEC1B	Q9P126	21	54	1	229	Chain	ID=PRO_0000280043;Note=C-type lectin domain family 1 member B
CLEC1B	Q9P126	21	54	1	33	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC1B	Q9P126	21	54	34	54	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC1B	Q9P126	21	54	22	55	Alternative sequence	ID=VSP_023515;Note=In isoform 2. VGSASSSWWRVMALILLILCVGMVVGLVALGIWS->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLEC1B	Q9P126	21	54	24	24	Natural variant	ID=VAR_031048;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs2273986,PMID:12975309
CLEC1B	Q9P126	21	54	28	28	Natural variant	ID=VAR_031049;Note=S->F;Dbxref=dbSNP:rs2273987
CLEC1B	Q9P126	21	54	41	41	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC1B	Q9P126	21	54	41	41	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC5A	Q9NY25	46	69	1	188	Chain	ID=PRO_0000046632;Note=C-type lectin domain family 5 member A
CLEC5A	Q9NY25	26	46	1	188	Chain	ID=PRO_0000046632;Note=C-type lectin domain family 5 member A
CLEC5A	Q9NY25	26	46	5	27	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC5A	Q9NY25	46	69	28	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC5A	Q9NY25	26	46	28	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC5A	Q9NY25	26	46	32	32	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLCN3	P51790	312	339	1	818	Chain	ID=PRO_0000094438;Note=H(+)/Cl(-) exchange transporter 3
CLCN3	P51790	583	716	1	818	Chain	ID=PRO_0000094438;Note=H(+)/Cl(-) exchange transporter 3
CLCN3	P51790	312	339	313	325	Intramembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	312	339	329	337	Intramembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	572	586	Intramembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	590	601	Intramembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	602	605	Intramembrane	Note=Note%3DLoop between two helices;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	606	624	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	625	818	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	658	722	Domain	Note=CBS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCN3	P51790	583	716	689	691	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	583	716	630	630	Binding site	Note=Chloride;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	312	339	339	339	Site	Note=Mediates proton transfer from the protein to the inner aqueous phase;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN3	P51790	312	339	312	338	Alternative sequence	ID=VSP_045105;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLCN3	P51790	583	716	646	646	Sequence conflict	Note=E->EEF;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLCN3	P51790	583	716	646	646	Sequence conflict	Note=E->EEF;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLCN3	P51790	583	716	646	646	Sequence conflict	Note=E->EEF;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC17A	Q6ZS10	103	120	1	378	Chain	ID=PRO_0000319428;Note=C-type lectin domain family 17%2C member A
CLEC17A	Q6ZS10	103	120	1	172	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLIP4	Q8N3C7	388	418	1	705	Chain	ID=PRO_0000083529;Note=CAP-Gly domain-containing linker protein 4
CLIP4	Q8N3C7	466	511	1	705	Chain	ID=PRO_0000083529;Note=CAP-Gly domain-containing linker protein 4
CLIP4	Q8N3C7	388	418	1	705	Chain	ID=PRO_0000083529;Note=CAP-Gly domain-containing linker protein 4
CLIP4	Q8N3C7	466	511	1	705	Chain	ID=PRO_0000083529;Note=CAP-Gly domain-containing linker protein 4
CLIP4	Q8N3C7	466	511	505	547	Domain	Note=CAP-Gly 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00045
CLIP4	Q8N3C7	466	511	505	547	Domain	Note=CAP-Gly 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00045
CLIP4	Q8N3C7	466	511	424	474	Compositional bias	Note=Ser-rich
CLIP4	Q8N3C7	466	511	424	474	Compositional bias	Note=Ser-rich
CLIP4	Q8N3C7	466	511	468	705	Alternative sequence	ID=VSP_012970;Note=In isoform 4. LNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC->IYGFFNQAFLVFFILVCLFEFLSNIYSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLIP4	Q8N3C7	466	511	468	705	Alternative sequence	ID=VSP_012970;Note=In isoform 4. LNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC->IYGFFNQAFLVFFILVCLFEFLSNIYSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLIP4	Q8N3C7	466	511	511	511	Alternative sequence	ID=VSP_012971;Note=In isoform 2. P->PVL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
CLIP4	Q8N3C7	466	511	511	511	Alternative sequence	ID=VSP_012971;Note=In isoform 2. P->PVL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
CLIP4	Q8N3C7	466	511	486	486	Natural variant	ID=VAR_048675;Note=R->L;Dbxref=dbSNP:rs3100246
CLIP4	Q8N3C7	466	511	486	486	Natural variant	ID=VAR_048675;Note=R->L;Dbxref=dbSNP:rs3100246
CLIP4	Q8N3C7	466	511	499	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0W
CLIP4	Q8N3C7	466	511	499	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0W
CLIP4	Q8N3C7	466	511	508	512	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0W
CLIP4	Q8N3C7	466	511	508	512	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z0W
CNNM2	Q9H8M5	722	744	1	875	Chain	ID=PRO_0000295760;Note=Metal transporter CNNM2
CNNM2	Q9H8M5	722	744	390	875	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CNNM2	Q9H8M5	722	744	553	875	Alternative sequence	ID=VSP_027078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CNNM2	Q9H8M5	722	744	721	742	Alternative sequence	ID=VSP_027080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BATF3	Q9NR55	30	65	1	127	Chain	ID=PRO_0000326106;Note=Basic leucine zipper transcriptional factor ATF-like 3
BATF3	Q9NR55	30	65	35	98	Domain	Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
BATF3	Q9NR55	30	65	37	62	Region	Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
BATF3	Q9NR55	30	65	63	91	Region	Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978
BATF3	Q9NR55	30	65	31	31	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
BAZ1B	Q9UIG0	1083	1144	1	1483	Chain	ID=PRO_0000211170;Note=Tyrosine-protein kinase BAZ1B
BAZ1B	Q9UIG0	231	297	1	1483	Chain	ID=PRO_0000211170;Note=Tyrosine-protein kinase BAZ1B
BAZ1B	Q9UIG0	1083	1144	1	1483	Chain	ID=PRO_0000211170;Note=Tyrosine-protein kinase BAZ1B
BAZ1B	Q9UIG0	231	297	1	1483	Chain	ID=PRO_0000211170;Note=Tyrosine-protein kinase BAZ1B
BAZ1B	Q9UIG0	231	297	1	345	Region	Note=Mediates the tyrosine-protein kinase activity
BAZ1B	Q9UIG0	231	297	1	345	Region	Note=Mediates the tyrosine-protein kinase activity
BAZ1B	Q9UIG0	231	297	266	266	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
BAZ1B	Q9UIG0	231	297	266	266	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
BAZ1B	Q9UIG0	1083	1144	1089	1089	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
BAZ1B	Q9UIG0	1083	1144	1089	1089	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
BAZ1B	Q9UIG0	1083	1144	1107	1107	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BAZ1B	Q9UIG0	1083	1144	1107	1107	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BCL7B	Q9BQE9	88	145	1	202	Chain	ID=PRO_0000239829;Note=B-cell CLL/lymphoma 7 protein family member B
BCL7B	Q9BQE9	88	145	114	114	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
BCL7B	Q9BQE9	88	145	118	118	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
BCL7B	Q9BQE9	88	145	120	120	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q921K9
BCL7B	Q9BQE9	88	145	122	122	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
BCL7B	Q9BQE9	88	145	127	127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q921K9
BCL7B	Q9BQE9	88	145	61	88	Alternative sequence	ID=VSP_019277;Note=In isoform 2. KSNSSAAREPNGFPSDASANSSLLLEFQ->MPGPWLCPEFLLRKMTTLSCCLCSVWFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BCL7B	Q9BQE9	88	145	89	145	Alternative sequence	ID=VSP_045923;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
BECN1	Q14457	277	326	1	450	Chain	ID=PRO_0000218555;Note=Beclin-1
BECN1	Q14457	228	276	1	450	Chain	ID=PRO_0000218555;Note=Beclin-1
BECN1	Q14457	163	227	1	450	Chain	ID=PRO_0000218555;Note=Beclin-1
BECN1	Q14457	277	326	1	450	Chain	ID=PRO_0000218555;Note=Beclin-1
BECN1	Q14457	228	276	1	450	Chain	ID=PRO_0000218555;Note=Beclin-1
BECN1	Q14457	163	227	1	450	Chain	ID=PRO_0000218555;Note=Beclin-1
BECN1	Q14457	277	326	134	450	Chain	ID=PRO_0000435036;Note=Beclin-1-C 37 kDa;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21364619;Dbxref=PMID:21364619
BECN1	Q14457	228	276	134	450	Chain	ID=PRO_0000435036;Note=Beclin-1-C 37 kDa;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21364619;Dbxref=PMID:21364619
BECN1	Q14457	163	227	134	450	Chain	ID=PRO_0000435036;Note=Beclin-1-C 37 kDa;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21364619;Dbxref=PMID:21364619
BECN1	Q14457	277	326	134	450	Chain	ID=PRO_0000435036;Note=Beclin-1-C 37 kDa;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21364619;Dbxref=PMID:21364619
BECN1	Q14457	228	276	134	450	Chain	ID=PRO_0000435036;Note=Beclin-1-C 37 kDa;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21364619;Dbxref=PMID:21364619
BECN1	Q14457	163	227	134	450	Chain	ID=PRO_0000435036;Note=Beclin-1-C 37 kDa;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21364619;Dbxref=PMID:21364619
BECN1	Q14457	277	326	150	450	Chain	ID=PRO_0000435037;Note=Beclin-1-C 35 kDa;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:21364619,ECO:0000305|PubMed:26263979;Dbxref=PMID:21364619,PMID:26263979
BECN1	Q14457	228	276	150	450	Chain	ID=PRO_0000435037;Note=Beclin-1-C 35 kDa;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:21364619,ECO:0000305|PubMed:26263979;Dbxref=PMID:21364619,PMID:26263979
BECN1	Q14457	163	227	150	450	Chain	ID=PRO_0000435037;Note=Beclin-1-C 35 kDa;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:21364619,ECO:0000305|PubMed:26263979;Dbxref=PMID:21364619,PMID:26263979
BECN1	Q14457	277	326	150	450	Chain	ID=PRO_0000435037;Note=Beclin-1-C 35 kDa;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:21364619,ECO:0000305|PubMed:26263979;Dbxref=PMID:21364619,PMID:26263979
BECN1	Q14457	228	276	150	450	Chain	ID=PRO_0000435037;Note=Beclin-1-C 35 kDa;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:21364619,ECO:0000305|PubMed:26263979;Dbxref=PMID:21364619,PMID:26263979
BECN1	Q14457	163	227	150	450	Chain	ID=PRO_0000435037;Note=Beclin-1-C 35 kDa;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:21364619,ECO:0000305|PubMed:26263979;Dbxref=PMID:21364619,PMID:26263979
BECN1	Q14457	277	326	245	450	Region	Note=Evolutionary conserved domain (ECD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28445460;Dbxref=PMID:28445460
BECN1	Q14457	228	276	245	450	Region	Note=Evolutionary conserved domain (ECD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28445460;Dbxref=PMID:28445460
BECN1	Q14457	277	326	245	450	Region	Note=Evolutionary conserved domain (ECD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28445460;Dbxref=PMID:28445460
BECN1	Q14457	228	276	245	450	Region	Note=Evolutionary conserved domain (ECD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28445460;Dbxref=PMID:28445460
BECN1	Q14457	228	276	142	270	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BECN1	Q14457	163	227	142	270	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BECN1	Q14457	228	276	142	270	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BECN1	Q14457	163	227	142	270	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BECN1	Q14457	277	326	314	314	Sequence conflict	Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
BECN1	Q14457	277	326	314	314	Sequence conflict	Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
BECN1	Q14457	163	227	160	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFM
BECN1	Q14457	163	227	160	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFM
BECN1	Q14457	228	276	176	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HHE
BECN1	Q14457	163	227	176	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HHE
BECN1	Q14457	228	276	176	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HHE
BECN1	Q14457	163	227	176	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5HHE
BECN1	Q14457	277	326	276	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	228	276	276	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	276	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	228	276	276	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	282	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	282	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	300	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	300	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	326	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BECN1	Q14457	277	326	326	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DDP
BFSP1	Q12934	209	245	1	665	Chain	ID=PRO_0000063847;Note=Filensin
BFSP1	Q12934	146	178	1	665	Chain	ID=PRO_0000063847;Note=Filensin
BFSP1	Q12934	209	245	40	320	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
BFSP1	Q12934	146	178	40	320	Domain	Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188
BFSP1	Q12934	146	178	85	184	Region	Note=Coil 1B
BFSP1	Q12934	209	245	202	320	Region	Note=Coil 2
BFSP1	Q12934	146	178	176	177	Sequence conflict	Note=HK->TR;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAIAP2L1	Q9UHR4	213	269	1	511	Chain	ID=PRO_0000247854;Note=Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
BAIAP2L1	Q9UHR4	116	162	1	511	Chain	ID=PRO_0000247854;Note=Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
BAIAP2L1	Q9UHR4	42	71	1	511	Chain	ID=PRO_0000247854;Note=Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
BAIAP2L1	Q9UHR4	213	269	1	249	Domain	Note=IMD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00668
BAIAP2L1	Q9UHR4	116	162	1	249	Domain	Note=IMD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00668
BAIAP2L1	Q9UHR4	42	71	1	249	Domain	Note=IMD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00668
BAIAP2L1	Q9UHR4	116	162	115	154	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BAIAP2L1	Q9UHR4	213	269	248	248	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
BAIAP2L1	Q9UHR4	213	269	257	257	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
BAIAP2L1	Q9UHR4	213	269	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:20068231,PMID:23186163
BAIAP2L1	Q9UHR4	116	162	141	141	Mutagenesis	Note=Loss ability to induce the formation of actin clusters%3B when associated with K-142%3B R-145 and K-146. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17430976;Dbxref=PMID:17430976
BAIAP2L1	Q9UHR4	116	162	142	142	Mutagenesis	Note=Loss ability to induce the formation of actin clusters%3B when associated with K-141%3B R-145 and K-146. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17430976;Dbxref=PMID:17430976
BAIAP2L1	Q9UHR4	116	162	145	145	Mutagenesis	Note=Loss ability to induce the formation of actin clusters%3B when associated with K-141%3B K-142 and K-146. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17430976;Dbxref=PMID:17430976
BAIAP2L1	Q9UHR4	116	162	146	146	Mutagenesis	Note=Loss ability to induce the formation of actin clusters%3B when associated with K-141%3B K-142 and R-145. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17430976;Dbxref=PMID:17430976
CYHR1	Q6ZMK1	31	82	1	362	Chain	ID=PRO_0000328852;Note=Cysteine and histidine-rich protein 1
CYHR1	Q6ZMK1	31	82	68	114	Zinc finger	Note=RING-type%3B degenerate
CYHR1	Q6ZMK1	31	82	1	88	Alternative sequence	ID=VSP_032818;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9455484;Dbxref=PMID:14702039,PMID:9455484
BNIP2	Q12982	265	297	1	314	Chain	ID=PRO_0000064961;Note=BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
BNIP2	Q12982	236	264	1	314	Chain	ID=PRO_0000064961;Note=BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
BNIP2	Q12982	192	235	1	314	Chain	ID=PRO_0000064961;Note=BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
BNIP2	Q12982	39	98	1	314	Chain	ID=PRO_0000064961;Note=BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
BNIP2	Q12982	265	297	147	304	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
BNIP2	Q12982	236	264	147	304	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
BNIP2	Q12982	192	235	147	304	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
BNIP2	Q12982	39	98	41	41	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BNIP2	Q12982	39	98	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BNIP2	Q12982	39	98	87	87	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BNIP2	Q12982	39	98	89	89	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BNIP2	Q12982	39	98	92	92	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BPIFA3	Q9BQP9	93	128	22	254	Chain	ID=PRO_0000017187;Note=BPI fold-containing family A member 3
BPIFA3	Q9BQP9	93	128	93	129	Alternative sequence	ID=VSP_026471;Note=In isoform 2. SINITNIQLDCGGIQISFHKEWFSANISLEFDLELRP->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BRD1	O95696	786	821	1	1058	Chain	ID=PRO_0000211177;Note=Bromodomain-containing protein 1
BRD1	O95696	786	821	1	1058	Chain	ID=PRO_0000211177;Note=Bromodomain-containing protein 1
BRD1	O95696	786	821	803	803	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRD1	O95696	786	821	803	803	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRD1	O95696	786	821	786	786	Alternative sequence	ID=VSP_040262;Note=In isoform 2. E->EGDKSPPKLEPSDALPLPSNSETNSEPPTLKPVELNPEQSKLFKRVTFDNESHSACTQSALVSGRPPEPTRASSGDVPAAAASAVAEPASDVNRRTSVLFCKSKSVSPPKSAKNTETQPTSPQLGTKTFLSV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BRD1	O95696	786	821	786	786	Alternative sequence	ID=VSP_040262;Note=In isoform 2. E->EGDKSPPKLEPSDALPLPSNSETNSEPPTLKPVELNPEQSKLFKRVTFDNESHSACTQSALVSGRPPEPTRASSGDVPAAAASAVAEPASDVNRRTSVLFCKSKSVSPPKSAKNTETQPTSPQLGTKTFLSV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BRD3	Q15059	238	362	2	726	Chain	ID=PRO_0000211181;Note=Bromodomain-containing protein 3
BRD3	Q15059	71	117	2	726	Chain	ID=PRO_0000211181;Note=Bromodomain-containing protein 3
BRD3	Q15059	71	117	51	123	Domain	Note=Bromo 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
BRD3	Q15059	238	362	326	398	Domain	Note=Bromo 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
BRD3	Q15059	71	117	78	80	Region	Note=Acetylated histone H3 binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105114;Dbxref=PMID:27105114
BRD3	Q15059	238	362	263	263	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
BRD3	Q15059	238	362	281	281	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BRD3	Q15059	71	117	73	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NXB
BRD3	Q15059	71	117	83	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NXB
BRD3	Q15059	71	117	98	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NXB
BRD3	Q15059	238	362	310	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BRD3	Q15059	238	362	325	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BRD3	Q15059	238	362	328	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BRD3	Q15059	238	362	332	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BRD3	Q15059	238	362	340	344	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BRD3	Q15059	238	362	348	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BRD3	Q15059	238	362	358	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3S92
BSPRY	Q5W0U4	100	177	1	402	Chain	ID=PRO_0000244257;Note=B box and SPRY domain-containing protein
BSPRY	Q5W0U4	100	177	100	100	Sequence conflict	Note=V->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTBD9	Q96Q07	485	520	1	612	Chain	ID=PRO_0000186217;Note=BTB/POZ domain-containing protein 9
CD160	O95971	24	133	1	26	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD160	O95971	24	133	27	159	Chain	ID=PRO_0000014543;Note=CD160 antigen
CD160	O95971	24	133	27	122	Domain	Note=Ig-like V-type
CD160	O95971	24	133	28	28	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD160	O95971	24	133	44	112	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD160	O95971	24	133	61	68	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD160	O95971	24	133	91	91	Natural variant	ID=VAR_027747;Note=I->V;Dbxref=dbSNP:rs2231373
BZW1	Q7L1Q6	21	80	1	419	Chain	ID=PRO_0000254609;Note=Basic leucine zipper and W2 domain-containing protein 1
BZW1	Q7L1Q6	112	134	1	419	Chain	ID=PRO_0000254609;Note=Basic leucine zipper and W2 domain-containing protein 1
BZW1	Q7L1Q6	368	409	1	419	Chain	ID=PRO_0000254609;Note=Basic leucine zipper and W2 domain-containing protein 1
BZW1	Q7L1Q6	368	409	247	414	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
BZW1	Q7L1Q6	368	409	368	368	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CC2D1B	Q5T0F9	590	632	1	858	Chain	ID=PRO_0000288426;Note=Coiled-coil and C2 domain-containing protein 1B
CC2D1B	Q5T0F9	339	375	1	858	Chain	ID=PRO_0000288426;Note=Coiled-coil and C2 domain-containing protein 1B
CC2D1B	Q5T0F9	590	632	611	635	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CC2D1B	Q5T0F9	590	632	593	593	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BRN9
CC2D1B	Q5T0F9	590	632	596	596	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BRN9
CC2D1B	Q5T0F9	590	632	1	625	Alternative sequence	ID=VSP_025658;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CC2D1B	Q5T0F9	339	375	1	625	Alternative sequence	ID=VSP_025658;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CC2D1B	Q5T0F9	590	632	124	858	Alternative sequence	ID=VSP_025663;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CC2D1B	Q5T0F9	339	375	124	858	Alternative sequence	ID=VSP_025663;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CYP27C1	Q4G0S4	59	129	1	372	Chain	ID=PRO_0000293732;Note=Cytochrome P450 27C1
CYP27C1	Q4G0S4	59	129	1	372	Chain	ID=PRO_0000293732;Note=Cytochrome P450 27C1
C1orf131	Q8NDD1	150	170	1	293	Chain	ID=PRO_0000285029;Note=Uncharacterized protein C1orf131
C1orf131	Q8NDD1	150	170	163	163	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
C1orf131	Q8NDD1	150	170	151	166	Alternative sequence	ID=VSP_059466;Note=In isoform 4. QANPSVLERDVDTQEF->VMSWLAYIYVVNPLVL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C1orf131	Q8NDD1	150	170	151	151	Alternative sequence	ID=VSP_059467;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C1orf131	Q8NDD1	150	170	167	293	Alternative sequence	ID=VSP_059468;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABP1	Q9NZU7	15	75	2	370	Chain	ID=PRO_0000073513;Note=Calcium-binding protein 1
CABP1	Q9NZU7	15	75	45	48	Compositional bias	Note=Poly-Pro
CABP1	Q9NZU7	15	75	74	79	Compositional bias	Note=Poly-Ala
CABP1	Q9NZU7	15	75	1	300	Alternative sequence	ID=VSP_037936;Note=In isoform Calbrain. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9920909;Dbxref=PMID:9920909
CABP1	Q9NZU7	15	75	1	203	Alternative sequence	ID=VSP_037937;Note=In isoform S-CaBP1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10625670;Dbxref=PMID:10625670
CABP1	Q9NZU7	15	75	1	143	Alternative sequence	ID=VSP_037938;Note=In isoform L-CaBP1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10625670;Dbxref=PMID:10625670
DPY19L2	Q6NUT2	667	708	1	758	Chain	ID=PRO_0000311879;Note=Probable C-mannosyltransferase DPY19L2
DPY19L2	Q6NUT2	426	453	1	758	Chain	ID=PRO_0000311879;Note=Probable C-mannosyltransferase DPY19L2
DPY19L2	Q6NUT2	406	426	1	758	Chain	ID=PRO_0000311879;Note=Probable C-mannosyltransferase DPY19L2
DPY19L2	Q6NUT2	351	377	1	758	Chain	ID=PRO_0000311879;Note=Probable C-mannosyltransferase DPY19L2
DPY19L2	Q6NUT2	351	377	344	364	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L2	Q6NUT2	351	377	372	392	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L2	Q6NUT2	426	453	423	443	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L2	Q6NUT2	406	426	423	443	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L2	Q6NUT2	426	453	1	553	Alternative sequence	ID=VSP_056136;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPY19L2	Q6NUT2	406	426	1	553	Alternative sequence	ID=VSP_056136;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPY19L2	Q6NUT2	351	377	1	553	Alternative sequence	ID=VSP_056136;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CACUL1	Q86Y37	265	295	1	369	Chain	ID=PRO_0000119817;Note=CDK2-associated and cullin domain-containing protein 1
CDH12	P55289	175	215	55	794	Chain	ID=PRO_0000003792;Note=Cadherin-12
CDH12	P55289	175	215	55	794	Chain	ID=PRO_0000003792;Note=Cadherin-12
CDH12	P55289	175	215	55	609	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH12	P55289	175	215	55	609	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH12	P55289	175	215	161	269	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH12	P55289	175	215	161	269	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH12	P55289	175	215	176	215	Alternative sequence	ID=VSP_056449;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDH12	P55289	175	215	176	215	Alternative sequence	ID=VSP_056449;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CA8	P35219	139	171	1	290	Chain	ID=PRO_0000077433;Note=Carbonic anhydrase-related protein
CA8	P35219	139	171	27	289	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA8	P35219	139	171	141	141	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA8	P35219	139	171	137	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W2J
CA8	P35219	139	171	147	149	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W2J
CA8	P35219	139	171	153	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W2J
CA8	P35219	139	171	163	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W2J
CAPN14	A8MX76	618	657	1	684	Chain	ID=PRO_0000341373;Note=Calpain-14
CAPN14	A8MX76	618	657	586	621	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN14	A8MX76	618	657	651	684	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN14	A8MX76	618	657	518	683	Region	Note=Domain IV
CALY	Q9NYX4	45	82	1	217	Chain	ID=PRO_0000164368;Note=Neuron-specific vesicular protein calcyon
CALY	Q9NYX4	45	82	1	87	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CALY	Q9NYX4	45	82	73	73	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAPRIN1	Q14444	229	275	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	293	322	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	468	518	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	229	275	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	293	322	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	468	518	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	229	275	263	263	Natural variant	ID=VAR_042425;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7657653;Dbxref=dbSNP:rs1132973,PMID:7657653
CAPRIN1	Q14444	229	275	263	263	Natural variant	ID=VAR_042425;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7657653;Dbxref=dbSNP:rs1132973,PMID:7657653
CAPRIN1	Q14444	229	275	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CAPRIN1	Q14444	229	275	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CAPRIN1	Q14444	229	275	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CAPRIN1	Q14444	229	275	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
BMPER	Q8N8U9	309	344	40	685	Chain	ID=PRO_0000020820;Note=BMP-binding endothelial regulator protein
BMPER	Q8N8U9	359	469	40	685	Chain	ID=PRO_0000020820;Note=BMP-binding endothelial regulator protein
BMPER	Q8N8U9	309	344	299	358	Domain	Note=VWFC 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
BMPER	Q8N8U9	359	469	363	574	Domain	Note=VWFD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00580
BMPER	Q8N8U9	309	344	318	318	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPER	Q8N8U9	359	469	441	441	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPER	Q8N8U9	359	469	370	370	Natural variant	ID=VAR_065823;Note=In DSD. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20869035;Dbxref=dbSNP:rs387906993,PMID:20869035
BOK	Q9UMX3	73	116	1	212	Chain	ID=PRO_0000143086;Note=Bcl-2-related ovarian killer protein
BOK	Q9UMX3	73	116	70	78	Region	Note=Nuclear export signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16302269;Dbxref=PMID:16302269
BOK	Q9UMX3	73	116	66	82	Motif	Note=BH3
BOK	Q9UMX3	73	116	112	131	Motif	Note=BH1
BOK	Q9UMX3	73	116	1	78	Alternative sequence	ID=VSP_058599;Note=In isoform 2. Missing
BOK	Q9UMX3	73	116	71	73	Mutagenesis	Note=Significantly accumulates in the nucleus. Increases apoptotic activity. Does not interact with XPO1. LRL->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16302269;Dbxref=PMID:16302269
BOK	Q9UMX3	73	116	61	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CKV
BOK	Q9UMX3	73	116	85	87	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CKV
BOK	Q9UMX3	73	116	88	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CKV
BOK	Q9UMX3	73	116	100	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CKV
C2CD2	Q9Y426	164	199	1	696	Chain	ID=PRO_0000045386;Note=C2 domain-containing protein 2
C2CD2	Q9Y426	126	164	1	696	Chain	ID=PRO_0000045386;Note=C2 domain-containing protein 2
C2CD2	Q9Y426	93	126	1	696	Chain	ID=PRO_0000045386;Note=C2 domain-containing protein 2
C2CD2	Q9Y426	164	199	51	242	Domain	Note=SMP-LBD;Ontology_term=ECO:0000305;evidence=ECO:0000305
C2CD2	Q9Y426	126	164	51	242	Domain	Note=SMP-LBD;Ontology_term=ECO:0000305;evidence=ECO:0000305
C2CD2	Q9Y426	93	126	51	242	Domain	Note=SMP-LBD;Ontology_term=ECO:0000305;evidence=ECO:0000305
C2CD2	Q9Y426	126	164	1	155	Alternative sequence	ID=VSP_041071;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
C2CD2	Q9Y426	93	126	1	155	Alternative sequence	ID=VSP_041071;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
C1RL	Q9NZP8	205	230	36	487	Chain	ID=PRO_0000318678;Note=Complement C1r subcomponent-like protein
C1RL	Q9NZP8	163	205	36	487	Chain	ID=PRO_0000318678;Note=Complement C1r subcomponent-like protein
C1RL	Q9NZP8	163	205	39	163	Domain	Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
C1RL	Q9NZP8	163	205	166	166	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
C1orf174	Q8IYL3	5	43	1	243	Chain	ID=PRO_0000294244;Note=UPF0688 protein C1orf174
SPECC1L	Q69YQ0	1029	1068	1	1117	Chain	ID=PRO_0000231018;Note=Cytospin-A
SPECC1L	Q69YQ0	1029	1068	1	1117	Chain	ID=PRO_0000231018;Note=Cytospin-A
SPECC1L	Q69YQ0	1029	1068	1011	1116	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
SPECC1L	Q69YQ0	1029	1068	1011	1116	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
SPECC1L	Q69YQ0	1029	1068	1030	1068	Alternative sequence	ID=VSP_047359;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPECC1L	Q69YQ0	1029	1068	1030	1068	Alternative sequence	ID=VSP_047359;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SPECC1L	Q69YQ0	1029	1068	1041	1041	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SPECC1L	Q69YQ0	1029	1068	1041	1041	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNB1	Q02641	350	382	1	598	Chain	ID=PRO_0000144046;Note=Voltage-dependent L-type calcium channel subunit beta-1
CACNB1	Q02641	350	382	381	381	Sequence conflict	Note=P->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDH20	Q9HBT6	220	276	60	801	Chain	ID=PRO_0000003820;Note=Cadherin-20
CDH20	Q9HBT6	549	633	60	801	Chain	ID=PRO_0000003820;Note=Cadherin-20
CDH20	Q9HBT6	220	276	60	801	Chain	ID=PRO_0000003820;Note=Cadherin-20
CDH20	Q9HBT6	549	633	60	801	Chain	ID=PRO_0000003820;Note=Cadherin-20
CDH20	Q9HBT6	220	276	60	801	Chain	ID=PRO_0000003820;Note=Cadherin-20
CDH20	Q9HBT6	549	633	60	801	Chain	ID=PRO_0000003820;Note=Cadherin-20
CDH20	Q9HBT6	220	276	60	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	549	633	60	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	220	276	60	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	549	633	60	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	220	276	60	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	549	633	60	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	549	633	620	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	549	633	620	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	549	633	620	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	220	276	166	274	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	220	276	166	274	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	220	276	166	274	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	220	276	275	389	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	220	276	275	389	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	220	276	275	389	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	549	633	494	610	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	549	633	494	610	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	549	633	494	610	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH20	Q9HBT6	220	276	261	261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	220	276	261	261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	220	276	261	261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH20	Q9HBT6	220	276	228	228	Natural variant	ID=VAR_036103;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
CDH20	Q9HBT6	220	276	228	228	Natural variant	ID=VAR_036103;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
CDH20	Q9HBT6	220	276	228	228	Natural variant	ID=VAR_036103;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
CDH20	Q9HBT6	549	633	621	621	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDH20	Q9HBT6	549	633	621	621	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDH20	Q9HBT6	549	633	621	621	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNA1S	Q13698	1203	1222	1	1873	Chain	ID=PRO_0000053943;Note=Voltage-dependent L-type calcium channel subunit alpha-1S
CACNA1S	Q13698	830	850	1	1873	Chain	ID=PRO_0000053943;Note=Voltage-dependent L-type calcium channel subunit alpha-1S
CACNA1S	Q13698	830	850	819	830	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNA1S	Q13698	830	850	831	850	Transmembrane	Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07293
CACNA1S	Q13698	1203	1222	1201	1231	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNA1S	Q13698	830	850	786	1068	Repeat	Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNA1S	Q13698	1203	1222	1105	1384	Repeat	Note=IV;Ontology_term=ECO:0000305;evidence=ECO:0000305
CALD1	Q05682	24	72	1	793	Chain	ID=PRO_0000089288;Note=Caldesmon
CALD1	Q05682	436	462	1	793	Chain	ID=PRO_0000089288;Note=Caldesmon
CALD1	Q05682	733	765	1	793	Chain	ID=PRO_0000089288;Note=Caldesmon
CALD1	Q05682	24	72	26	207	Region	Note=Myosin and calmodulin-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALD1	Q05682	24	72	39	46	Compositional bias	Note=Poly-Arg
CALD1	Q05682	733	765	753	753	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
CALD1	Q05682	733	765	759	759	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CALD1	Q05682	436	462	459	459	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CALD1	Q05682	24	72	1	24	Alternative sequence	ID=VSP_004154;Note=In isoform 3 and isoform 5. MDDFERRRELRRQKREEMRLEAER->MLGGSGSHGRRSLAALSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1465449;Dbxref=PMID:1465449
CALD1	Q05682	436	462	208	462	Alternative sequence	ID=VSP_004156;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1465449,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1555769,ECO:0000303|PubMed:1885618;Dbxref=PMID:1465449,PMID:15489334,PMID:1555769,PMID:1885618
CALD1	Q05682	436	462	208	436	Alternative sequence	ID=VSP_004155;Note=In isoform 2%2C isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1465449,ECO:0000303|PubMed:14702039;Dbxref=PMID:1465449,PMID:14702039
DNAAF3	Q8N9W5	160	221	1	541	Chain	ID=PRO_0000297580;Note=Dynein assembly factor 3%2C axonemal
DNAAF3	Q8N9W5	160	221	96	541	Alternative sequence	ID=VSP_039968;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAB2IP	Q5VWQ8	205	390	1	1189	Chain	ID=PRO_0000252407;Note=Disabled homolog 2-interacting protein
DAB2IP	Q5VWQ8	487	565	1	1189	Chain	ID=PRO_0000252407;Note=Disabled homolog 2-interacting protein
DAB2IP	Q5VWQ8	989	1040	1	1189	Chain	ID=PRO_0000252407;Note=Disabled homolog 2-interacting protein
DAB2IP	Q5VWQ8	205	390	200	295	Domain	Note=C2
DAB2IP	Q5VWQ8	205	390	371	563	Domain	Note=Ras-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00167
DAB2IP	Q5VWQ8	487	565	371	563	Domain	Note=Ras-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00167
DAB2IP	Q5VWQ8	989	1040	1026	1159	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DAB2IP	Q5VWQ8	989	1040	995	995	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAB2IP	Q5VWQ8	205	390	228	230	Mutagenesis	Note=Reduces interaction with KDR/VEGFR2. Does not inhibit interaction with MAP3K5. KKK->AAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12813029,ECO:0000269|PubMed:19033661;Dbxref=PMID:12813029,PMID:19033661
DAB2IP	Q5VWQ8	205	390	281	284	Mutagenesis	Note=Significantly reduces interaction with MAP3K5. Does not reduce interaction with KDR/VEGFR2. KKKK->AAAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12813029,ECO:0000269|PubMed:19033661;Dbxref=PMID:12813029,PMID:19033661
CALR	P27797	30	64	18	417	Chain	ID=PRO_0000004173;Note=Calreticulin
CALR	P27797	64	132	18	417	Chain	ID=PRO_0000004173;Note=Calreticulin
CALR	P27797	272	320	18	417	Chain	ID=PRO_0000004173;Note=Calreticulin
CALR	P27797	272	320	273	283	Repeat	Note=2-2
CALR	P27797	272	320	287	297	Repeat	Note=2-3
CALR	P27797	30	64	18	197	Region	Note=N-domain
CALR	P27797	64	132	18	197	Region	Note=N-domain
CALR	P27797	272	320	198	308	Region	Note=P-domain
CALR	P27797	272	320	259	297	Region	Note=3 X approximate repeats
CALR	P27797	272	320	309	417	Region	Note=C-domain
CALR	P27797	30	64	62	62	Metal binding	Note=Calcium%3B via carbonyl oxygen
CALR	P27797	30	64	64	64	Metal binding	Note=Calcium%3B via carbonyl oxygen
CALR	P27797	64	132	64	64	Metal binding	Note=Calcium%3B via carbonyl oxygen
CALR	P27797	64	132	109	109	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	64	132	111	111	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	64	132	128	128	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	272	320	317	317	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	30	64	48	48	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CALR	P27797	64	132	105	137	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11322874,ECO:0000269|PubMed:21423620;Dbxref=PMID:11322874,PMID:21423620
CALR	P27797	30	64	30	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	42	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	60	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	65	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	70	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	91	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	104	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	119	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	129	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	272	320	303	306	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LK5
CALR	P27797	272	320	311	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CAPN5	O15484	298	323	1	640	Chain	ID=PRO_0000207713;Note=Calpain-5
CAPN5	O15484	298	323	1	640	Chain	ID=PRO_0000207713;Note=Calpain-5
CAPN5	O15484	298	323	26	343	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN5	O15484	298	323	26	343	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN7	Q9Y6W3	146	212	1	813	Chain	ID=PRO_0000207720;Note=Calpain-7
CAPN7	Q9Y6W3	735	765	1	813	Chain	ID=PRO_0000207720;Note=Calpain-7
CAPN7	Q9Y6W3	735	765	702	813	Region	Note=Domain N
CAPN7	Q9Y6W3	735	765	737	747	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QFE
CAPN7	Q9Y6W3	735	765	758	761	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2QFE
CAPN9	O14815	235	263	1	690	Chain	ID=PRO_0000207722;Note=Calpain-9
CAPN9	O14815	292	317	1	690	Chain	ID=PRO_0000207722;Note=Calpain-9
CAPN9	O14815	506	533	1	690	Chain	ID=PRO_0000207722;Note=Calpain-9
CAPN9	O14815	235	263	42	337	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN9	O14815	292	317	42	337	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN9	O14815	506	533	518	552	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN9	O14815	506	533	338	521	Region	Note=Domain III
CAPN9	O14815	506	533	522	690	Region	Note=Domain IV
CAPN9	O14815	235	263	254	254	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17157313;Dbxref=PMID:17157313
CAPN9	O14815	292	317	312	312	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
CAPN9	O14815	292	317	314	314	Metal binding	Note=Calcium 2
CAPN9	O14815	292	317	316	316	Metal binding	Note=Calcium 2%3B via carbonyl oxygen
CAPN9	O14815	292	317	292	318	Alternative sequence	ID=VSP_007553;Note=In isoform 2. SSPEWRSVGPAEQKRLCHTALDDGEFW->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10835488;Dbxref=PMID:10835488
CAPN9	O14815	235	263	239	239	Natural variant	ID=VAR_022192;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28359647
CAPN9	O14815	506	533	522	522	Natural variant	ID=VAR_022198;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs12731961
CAPN9	O14815	235	263	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZIV
CAPN9	O14815	235	263	256	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZIV
CAPN9	O14815	292	317	294	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZIV
CAPN9	O14815	292	317	301	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZIV
CAPN9	O14815	292	317	313	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZIV
CANT1	Q8WVQ1	210	278	1	401	Chain	ID=PRO_0000209925;Note=Soluble calcium-activated nucleotidase 1
CANT1	Q8WVQ1	210	278	1	401	Chain	ID=PRO_0000209925;Note=Soluble calcium-activated nucleotidase 1
CANT1	Q8WVQ1	210	278	1	401	Chain	ID=PRO_0000209925;Note=Soluble calcium-activated nucleotidase 1
CANT1	Q8WVQ1	210	278	63	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CANT1	Q8WVQ1	210	278	63	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CANT1	Q8WVQ1	210	278	63	401	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CANT1	Q8WVQ1	210	278	215	215	Metal binding	Note=Calcium%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1S18,ECO:0000244|PDB:1S1D,ECO:0000244|PDB:2H2N,ECO:0000244|PDB:2H2U,ECO:0000269|PubMed:15006348,ECO:0000269|PubMed:16835225;Dbxref=PMID:15006348,PMID:16835225
CANT1	Q8WVQ1	210	278	215	215	Metal binding	Note=Calcium%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1S18,ECO:0000244|PDB:1S1D,ECO:0000244|PDB:2H2N,ECO:0000244|PDB:2H2U,ECO:0000269|PubMed:15006348,ECO:0000269|PubMed:16835225;Dbxref=PMID:15006348,PMID:16835225
CANT1	Q8WVQ1	210	278	215	215	Metal binding	Note=Calcium%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1S18,ECO:0000244|PDB:1S1D,ECO:0000244|PDB:2H2N,ECO:0000244|PDB:2H2U,ECO:0000269|PubMed:15006348,ECO:0000269|PubMed:16835225;Dbxref=PMID:15006348,PMID:16835225
CANT1	Q8WVQ1	210	278	256	256	Site	Note=Important for dimer formation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16835225;Dbxref=PMID:16835225
CANT1	Q8WVQ1	210	278	256	256	Site	Note=Important for dimer formation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16835225;Dbxref=PMID:16835225
CANT1	Q8WVQ1	210	278	256	256	Site	Note=Important for dimer formation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16835225;Dbxref=PMID:16835225
CANT1	Q8WVQ1	210	278	220	245	Alternative sequence	ID=VSP_013760;Note=In isoform 2. KDERLYVGGLGKEWTTTTGDVVNENP->REIVRKRWRLVKQVSHVGVLGQWIQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12761501;Dbxref=PMID:12761501
CANT1	Q8WVQ1	210	278	220	245	Alternative sequence	ID=VSP_013760;Note=In isoform 2. KDERLYVGGLGKEWTTTTGDVVNENP->REIVRKRWRLVKQVSHVGVLGQWIQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12761501;Dbxref=PMID:12761501
CANT1	Q8WVQ1	210	278	220	245	Alternative sequence	ID=VSP_013760;Note=In isoform 2. KDERLYVGGLGKEWTTTTGDVVNENP->REIVRKRWRLVKQVSHVGVLGQWIQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12761501;Dbxref=PMID:12761501
CANT1	Q8WVQ1	210	278	246	401	Alternative sequence	ID=VSP_013761;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12761501;Dbxref=PMID:12761501
CANT1	Q8WVQ1	210	278	246	401	Alternative sequence	ID=VSP_013761;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12761501;Dbxref=PMID:12761501
CANT1	Q8WVQ1	210	278	246	401	Alternative sequence	ID=VSP_013761;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12761501;Dbxref=PMID:12761501
CANT1	Q8WVQ1	210	278	224	224	Natural variant	ID=VAR_068658;Note=In DBQD1%3B affects protein stability and secretion. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21037275;Dbxref=dbSNP:rs150181226,PMID:21037275
CANT1	Q8WVQ1	210	278	224	224	Natural variant	ID=VAR_068658;Note=In DBQD1%3B affects protein stability and secretion. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21037275;Dbxref=dbSNP:rs150181226,PMID:21037275
CANT1	Q8WVQ1	210	278	224	224	Natural variant	ID=VAR_068658;Note=In DBQD1%3B affects protein stability and secretion. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21037275;Dbxref=dbSNP:rs150181226,PMID:21037275
CANT1	Q8WVQ1	210	278	226	226	Natural variant	ID=VAR_068659;Note=In DBQD1 and EDM7%3B severely affects activity. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21037275,ECO:0000269|PubMed:21412251,ECO:0000269|PubMed:28742282;Dbxref=dbSNP:rs377546036,PMID:21037275,PMID:21412251,PMID:28742282
CANT1	Q8WVQ1	210	278	226	226	Natural variant	ID=VAR_068659;Note=In DBQD1 and EDM7%3B severely affects activity. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21037275,ECO:0000269|PubMed:21412251,ECO:0000269|PubMed:28742282;Dbxref=dbSNP:rs377546036,PMID:21037275,PMID:21412251,PMID:28742282
CANT1	Q8WVQ1	210	278	226	226	Natural variant	ID=VAR_068659;Note=In DBQD1 and EDM7%3B severely affects activity. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21037275,ECO:0000269|PubMed:21412251,ECO:0000269|PubMed:28742282;Dbxref=dbSNP:rs377546036,PMID:21037275,PMID:21412251,PMID:28742282
CANT1	Q8WVQ1	210	278	215	215	Mutagenesis	Note=Reduces activity by 99%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15006348;Dbxref=PMID:15006348
CANT1	Q8WVQ1	210	278	215	215	Mutagenesis	Note=Reduces activity by 99%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15006348;Dbxref=PMID:15006348
CANT1	Q8WVQ1	210	278	215	215	Mutagenesis	Note=Reduces activity by 99%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15006348;Dbxref=PMID:15006348
CANT1	Q8WVQ1	210	278	246	246	Mutagenesis	Note=Increases activity 5-fold. E->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15006348;Dbxref=PMID:15006348
CANT1	Q8WVQ1	210	278	246	246	Mutagenesis	Note=Increases activity 5-fold. E->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15006348;Dbxref=PMID:15006348
CANT1	Q8WVQ1	210	278	246	246	Mutagenesis	Note=Increases activity 5-fold. E->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15006348;Dbxref=PMID:15006348
CANT1	Q8WVQ1	210	278	256	256	Mutagenesis	Note=No effect on GDPase and ADPase activities. No effect on dimer formation%3B when associated with S-287. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16835225;Dbxref=PMID:16835225
CANT1	Q8WVQ1	210	278	256	256	Mutagenesis	Note=No effect on GDPase and ADPase activities. No effect on dimer formation%3B when associated with S-287. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16835225;Dbxref=PMID:16835225
CANT1	Q8WVQ1	210	278	256	256	Mutagenesis	Note=No effect on GDPase and ADPase activities. No effect on dimer formation%3B when associated with S-287. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16835225;Dbxref=PMID:16835225
CANT1	Q8WVQ1	210	278	208	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	208	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	208	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	216	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	216	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	216	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	240	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	247	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	247	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	247	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	257	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	257	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	257	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	263	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	263	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
CANT1	Q8WVQ1	210	278	263	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S1D
NOS1AP	O75052	35	59	1	506	Chain	ID=PRO_0000089316;Note=Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
NOS1AP	O75052	35	59	26	196	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
NOS1AP	O75052	35	59	18	312	Alternative sequence	ID=VSP_042752;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16146415;Dbxref=PMID:16146415
C4BPA	P04003	424	481	49	597	Chain	ID=PRO_0000005888;Note=C4b-binding protein alpha chain
C4BPA	P04003	424	481	363	424	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPA	P04003	424	481	425	482	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPA	P04003	424	481	426	468	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPA	P04003	424	481	454	480	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPA	P04003	424	481	473	473	Natural variant	ID=VAR_012038;Note=W->L;Dbxref=dbSNP:rs1801341
CST3	P01034	81	119	27	146	Chain	ID=PRO_0000006639;Note=Cystatin-C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2541223,ECO:0000269|PubMed:3495457;Dbxref=PMID:2541223,PMID:3495457
CST3	P01034	81	119	27	146	Chain	ID=PRO_0000006639;Note=Cystatin-C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2541223,ECO:0000269|PubMed:3495457;Dbxref=PMID:2541223,PMID:3495457
CST3	P01034	81	119	81	85	Motif	Note=Secondary area of contact
CST3	P01034	81	119	81	85	Motif	Note=Secondary area of contact
CST3	P01034	81	119	99	109	Disulfide bond	.
CST3	P01034	81	119	99	109	Disulfide bond	.
CST3	P01034	81	119	94	94	Natural variant	ID=VAR_002207;Note=In AMYL6. L->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1352269,ECO:0000269|PubMed:2541223;Dbxref=dbSNP:rs28939068,PMID:1352269,PMID:2541223
CST3	P01034	81	119	94	94	Natural variant	ID=VAR_002207;Note=In AMYL6. L->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1352269,ECO:0000269|PubMed:2541223;Dbxref=dbSNP:rs28939068,PMID:1352269,PMID:2541223
CST3	P01034	81	119	67	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GAX
CST3	P01034	81	119	67	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GAX
CST3	P01034	81	119	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R4C
CST3	P01034	81	119	106	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R4C
CST3	P01034	81	119	115	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GAX
CST3	P01034	81	119	115	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GAX
C1orf159	Q96HA4	85	117	19	380	Chain	ID=PRO_0000255250;Note=Uncharacterized protein C1orf159
C1orf159	Q96HA4	24	60	19	380	Chain	ID=PRO_0000255250;Note=Uncharacterized protein C1orf159
C1orf159	Q96HA4	85	117	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
C1orf159	Q96HA4	85	117	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
C1orf159	Q96HA4	85	117	1	126	Alternative sequence	ID=VSP_021280;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C1orf159	Q96HA4	24	60	1	126	Alternative sequence	ID=VSP_021280;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C1orf159	Q96HA4	24	60	25	60	Alternative sequence	ID=VSP_021281;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:14702039,PMID:15489334
CDH16	O75309	758	797	19	829	Chain	ID=PRO_0000003809;Note=Cadherin-16
CDH16	O75309	641	722	19	829	Chain	ID=PRO_0000003809;Note=Cadherin-16
CDH16	O75309	453	516	19	829	Chain	ID=PRO_0000003809;Note=Cadherin-16
CDH16	O75309	260	301	19	829	Chain	ID=PRO_0000003809;Note=Cadherin-16
CDH16	O75309	758	797	19	786	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH16	O75309	641	722	19	786	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH16	O75309	453	516	19	786	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH16	O75309	260	301	19	786	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH16	O75309	758	797	787	807	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH16	O75309	260	301	242	336	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH16	O75309	453	516	455	564	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH16	O75309	641	722	569	665	Domain	Note=Cadherin 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH16	O75309	758	797	666	786	Region	Note=Ectodomain G
CDH16	O75309	641	722	666	786	Region	Note=Ectodomain G
CDH16	O75309	641	722	722	722	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH16	O75309	641	722	642	680	Alternative sequence	ID=VSP_046467;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDH16	O75309	641	722	642	663	Alternative sequence	ID=VSP_013354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
CDH16	O75309	641	722	717	717	Natural variant	ID=VAR_061058;Note=R->H;Dbxref=dbSNP:rs34621310
CDH17	Q12864	761	799	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	642	722	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	261	305	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	141	194	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	761	799	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	642	722	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	261	305	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	141	194	23	832	Chain	ID=PRO_0000003812;Note=Cadherin-17
CDH17	Q12864	761	799	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	642	722	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	261	305	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	141	194	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	761	799	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	642	722	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	261	305	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	141	194	23	787	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	761	799	788	808	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	761	799	788	808	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	141	194	129	244	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	141	194	129	244	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	261	305	245	340	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	261	305	245	340	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	642	722	567	667	Domain	Note=Cadherin 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	642	722	567	667	Domain	Note=Cadherin 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	761	799	668	777	Domain	Note=Cadherin 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	642	722	668	777	Domain	Note=Cadherin 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	761	799	668	777	Domain	Note=Cadherin 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	642	722	668	777	Domain	Note=Cadherin 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH17	Q12864	141	194	149	149	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	141	194	149	149	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	141	194	184	184	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	141	194	184	184	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	642	722	722	722	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH17	Q12864	642	722	722	722	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM4	Q8NFZ8	309	352	21	388	Chain	ID=PRO_0000291980;Note=Cell adhesion molecule 4
CADM4	Q8NFZ8	121	166	21	388	Chain	ID=PRO_0000291980;Note=Cell adhesion molecule 4
CADM4	Q8NFZ8	309	352	21	324	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM4	Q8NFZ8	121	166	21	324	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM4	Q8NFZ8	309	352	325	345	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM4	Q8NFZ8	309	352	346	388	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM4	Q8NFZ8	121	166	124	219	Domain	Note=Ig-like C2-type 1
CADM4	Q8NFZ8	121	166	145	199	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
DPY19L3	Q6ZPD9	329	363	1	716	Chain	ID=PRO_0000311901;Note=Probable C-mannosyltransferase DPY19L3
DPY19L3	Q6ZPD9	329	363	1	716	Chain	ID=PRO_0000311901;Note=Probable C-mannosyltransferase DPY19L3
DPY19L3	Q6ZPD9	329	363	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L3	Q6ZPD9	329	363	342	362	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L3	Q6ZPD9	329	363	350	350	Natural variant	ID=VAR_037336;Note=M->V;Dbxref=dbSNP:rs8105178
DPY19L3	Q6ZPD9	329	363	350	350	Natural variant	ID=VAR_037336;Note=M->V;Dbxref=dbSNP:rs8105178
CABP4	P57796	132	180	1	275	Chain	ID=PRO_0000073521;Note=Calcium-binding protein 4
CABP4	P57796	132	180	129	164	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CABP4	P57796	132	180	165	200	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CABP4	P57796	132	180	142	153	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CDH11	P55287	547	631	54	796	Chain	ID=PRO_0000003786;Note=Cadherin-11
CDH11	P55287	547	631	54	617	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH11	P55287	547	631	618	640	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH11	P55287	547	631	487	612	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH11	P55287	547	631	232	796	Natural variant	ID=VAR_080481;Note=In ESWS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29271567;Dbxref=PMID:29271567
CA6	P23280	26	86	18	308	Chain	ID=PRO_0000004241;Note=Carbonic anhydrase 6
CA6	P23280	26	86	21	278	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA6	P23280	26	86	85	85	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00918
CA6	P23280	26	86	67	67	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA6	P23280	26	86	42	224	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CA6	P23280	26	86	27	86	Alternative sequence	ID=VSP_046668;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CA6	P23280	26	86	37	37	Natural variant	ID=VAR_033712;Note=Q->L;Dbxref=dbSNP:rs34265054
CA6	P23280	26	86	55	55	Natural variant	ID=VAR_028268;Note=T->M;Dbxref=dbSNP:rs2274327
CA6	P23280	26	86	58	58	Natural variant	ID=VAR_061093;Note=R->W;Dbxref=dbSNP:rs58800854
CA6	P23280	26	86	68	68	Natural variant	ID=VAR_028269;Note=M->L;Dbxref=dbSNP:rs2274328
CA6	P23280	26	86	70	70	Natural variant	ID=VAR_028270;Note=G->A;Dbxref=dbSNP:rs2274329
CA6	P23280	26	86	35	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE4
CA6	P23280	26	86	40	43	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE4
CA6	P23280	26	86	44	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE4
CA6	P23280	26	86	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE4
CA6	P23280	26	86	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE4
CA6	P23280	26	86	72	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE4
CA9	Q16790	249	280	38	459	Chain	ID=PRO_0000004243;Note=Carbonic anhydrase 9
CA9	Q16790	249	280	38	414	Topological domain	Note=Extracellular
CA9	Q16790	249	280	139	390	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA9	Q16790	249	280	113	414	Region	Note=Catalytic
CA9	Q16790	249	280	251	251	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19805286;Dbxref=PMID:19805286
CA9	Q16790	249	280	156	336	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19805286;Dbxref=PMID:19805286
CA9	Q16790	249	280	247	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DVX
CA9	Q16790	249	280	262	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DVX
CA9	Q16790	249	280	271	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DVX
CHAF1B	Q13112	354	497	1	559	Chain	ID=PRO_0000050896;Note=Chromatin assembly factor 1 subunit B
CHAF1B	Q13112	354	497	344	385	Repeat	Note=WD 7
CHAF1B	Q13112	354	497	394	394	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHAF1B	Q13112	354	497	409	409	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
CHAF1B	Q13112	354	497	419	419	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CHAF1B	Q13112	354	497	429	429	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
CHAF1B	Q13112	354	497	433	433	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CHAF1B	Q13112	354	497	458	458	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
CHAF1B	Q13112	354	497	494	494	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CHAF1B	Q13112	354	497	495	495	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHAF1B	Q13112	354	497	494	494	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAPN13	Q6MZZ7	233	258	1	669	Chain	ID=PRO_0000259582;Note=Calpain-13
CAPN13	Q6MZZ7	233	258	34	333	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN13	Q6MZZ7	233	258	249	249	Active site	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN13	Q6MZZ7	233	258	249	249	Natural variant	ID=VAR_028964;Note=H->Y;Dbxref=dbSNP:rs17010210
CAPN2	P17655	243	271	20	700	Chain	ID=PRO_0000026488;Note=Calpain-2 catalytic subunit
CAPN2	P17655	243	271	45	344	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN2	P17655	243	271	262	262	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CAPN2	P17655	243	271	256	256	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAPN2	P17655	243	271	247	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NQA
CAPN2	P17655	243	271	259	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NQA
CAPN2	P17655	243	271	264	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NQA
CAPN8	A6NHC0	615	654	1	703	Chain	ID=PRO_0000349280;Note=Calpain-8
CAPN8	A6NHC0	615	654	605	640	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN8	A6NHC0	615	654	618	629	Calcium binding	Note=2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAP1	Q01518	72	98	2	475	Chain	ID=PRO_0000205696;Note=Adenylyl cyclase-associated protein 1
CAP1	Q01518	72	98	2	475	Chain	ID=PRO_0000205696;Note=Adenylyl cyclase-associated protein 1
CAP1	Q01518	72	98	2	475	Chain	ID=PRO_0000205696;Note=Adenylyl cyclase-associated protein 1
CAP1	Q01518	72	98	81	81	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CAP1	Q01518	72	98	81	81	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CAP1	Q01518	72	98	81	81	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CAP2	P40123	74	100	2	477	Chain	ID=PRO_0000205700;Note=Adenylyl cyclase-associated protein 2
CAP2	P40123	403	450	2	477	Chain	ID=PRO_0000205700;Note=Adenylyl cyclase-associated protein 2
CAP2	P40123	403	450	317	455	Domain	Note=C-CAP/cofactor C-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00659
CAP2	P40123	74	100	75	334	Alternative sequence	ID=VSP_055519;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CADPS	Q9ULU8	1223	1259	1	1353	Chain	ID=PRO_0000053864;Note=Calcium-dependent secretion activator 1
CADPS	Q9ULU8	1212	1223	1	1353	Chain	ID=PRO_0000053864;Note=Calcium-dependent secretion activator 1
CADPS	Q9ULU8	1159	1184	1	1353	Chain	ID=PRO_0000053864;Note=Calcium-dependent secretion activator 1
CADPS	Q9ULU8	1009	1057	1	1353	Chain	ID=PRO_0000053864;Note=Calcium-dependent secretion activator 1
CADPS	Q9ULU8	1009	1057	931	1111	Domain	Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587
CADPS	Q9ULU8	1009	1057	790	1129	Region	Note=Interaction with DRD2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15857609;Dbxref=PMID:15857609
CADPS	Q9ULU8	1223	1259	1177	1353	Region	Note=Mediates targeting and association with DCVs;Ontology_term=ECO:0000250;evidence=ECO:0000250
CADPS	Q9ULU8	1212	1223	1177	1353	Region	Note=Mediates targeting and association with DCVs;Ontology_term=ECO:0000250;evidence=ECO:0000250
CADPS	Q9ULU8	1159	1184	1177	1353	Region	Note=Mediates targeting and association with DCVs;Ontology_term=ECO:0000250;evidence=ECO:0000250
CADPS	Q9ULU8	1223	1259	458	1353	Alternative sequence	ID=VSP_016802;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CADPS	Q9ULU8	1212	1223	458	1353	Alternative sequence	ID=VSP_016802;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CADPS	Q9ULU8	1159	1184	458	1353	Alternative sequence	ID=VSP_016802;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CADPS	Q9ULU8	1009	1057	458	1353	Alternative sequence	ID=VSP_016802;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CADPS	Q9ULU8	1009	1057	1009	1058	Alternative sequence	ID=VSP_016807;Note=In isoform 2 and isoform 3. KSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDAD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12659812,ECO:0000303|PubMed:17974005;Dbxref=PMID:12659812,PMID:17974005
CADPS	Q9ULU8	1159	1184	1159	1159	Alternative sequence	ID=VSP_016808;Note=In isoform 4. E->EFAKMW;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9289490;Dbxref=PMID:15489334,PMID:9289490
CADPS	Q9ULU8	1223	1259	1230	1230	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CADPS	Q9ULU8	1223	1259	1237	1237	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CADPS	Q9ULU8	1223	1259	1250	1250	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CADPS	Q9ULU8	1223	1259	1250	1250	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSL	P07711	83	132	18	113	Propeptide	ID=PRO_0000026244;Note=Activation peptide
CTSL	P07711	83	132	18	113	Propeptide	ID=PRO_0000026244;Note=Activation peptide
CTSL	P07711	83	132	114	288	Chain	ID=PRO_0000026245;Note=Cathepsin L1 heavy chain
CTSL	P07711	132	207	114	288	Chain	ID=PRO_0000026245;Note=Cathepsin L1 heavy chain
CTSL	P07711	83	132	114	288	Chain	ID=PRO_0000026245;Note=Cathepsin L1 heavy chain
CTSL	P07711	132	207	114	288	Chain	ID=PRO_0000026245;Note=Cathepsin L1 heavy chain
CTSL	P07711	132	207	138	138	Active site	.
CTSL	P07711	132	207	138	138	Active site	.
CTSL	P07711	132	207	135	178	Disulfide bond	.
CTSL	P07711	132	207	135	178	Disulfide bond	.
CTSL	P07711	132	207	169	211	Disulfide bond	.
CTSL	P07711	132	207	169	211	Disulfide bond	.
CTSL	P07711	83	132	85	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CS8
CTSL	P07711	83	132	85	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CS8
CTSL	P07711	83	132	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CJL
CTSL	P07711	83	132	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CJL
CTSL	P07711	83	132	116	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EZX
CTSL	P07711	83	132	116	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EZX
CTSL	P07711	83	132	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	83	132	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	138	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	138	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	163	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	163	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	171	174	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	171	174	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU4
CTSL	P07711	132	207	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU4
CTSL	P07711	132	207	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
CTSL	P07711	132	207	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XU3
BRPF1	P55201	872	967	1	1214	Chain	ID=PRO_0000211187;Note=Peregrin
BRPF1	P55201	872	967	543	1079	Region	Note=Required for RUNX1 and RUNX2 transcriptional activation
BRPF1	P55201	872	967	917	917	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B2RRD7
BRPF1	P55201	872	967	922	922	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B2RRD7
BRPF1	P55201	872	967	926	926	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B2RRD7
BRPF1	P55201	872	967	873	967	Alternative sequence	ID=VSP_037957;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BRPF1	P55201	872	967	35	1214	Natural variant	ID=VAR_078076;Note=In IDDDFP. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27939639;Dbxref=PMID:27939639
BRPF1	P55201	872	967	455	1214	Natural variant	ID=VAR_078079;Note=In IDDDFP%3B decreased histone H3-K23 acetylation%3B increased localization to the nucleus%3B decreased expression and assembly of the MOZ/MORF complex. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27939640;Dbxref=PMID:27939640
BRPF1	P55201	872	967	833	1214	Natural variant	ID=VAR_078080;Note=In IDDDFP%3B no effect on histone H3-K23 acetylation%3B increased aggregation in the cytoplasm%3B no effect on expression and assembly of the MOZ/MORF complex. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27939640;Dbxref=PMID:27939640
BRCA2	P51587	22	105	1	3418	Chain	ID=PRO_0000064984;Note=Breast cancer type 2 susceptibility protein
BRCA2	P51587	2280	2312	1	3418	Chain	ID=PRO_0000064984;Note=Breast cancer type 2 susceptibility protein
BRCA2	P51587	2777	2829	1	3418	Chain	ID=PRO_0000064984;Note=Breast cancer type 2 susceptibility protein
BRCA2	P51587	22	105	1	3418	Chain	ID=PRO_0000064984;Note=Breast cancer type 2 susceptibility protein
BRCA2	P51587	2280	2312	1	3418	Chain	ID=PRO_0000064984;Note=Breast cancer type 2 susceptibility protein
BRCA2	P51587	2777	2829	1	3418	Chain	ID=PRO_0000064984;Note=Breast cancer type 2 susceptibility protein
BRCA2	P51587	22	105	1	40	Region	Note=Interaction with PALB2
BRCA2	P51587	22	105	1	40	Region	Note=Interaction with PALB2
BRCA2	P51587	2777	2829	2481	2832	Region	Note=Interaction with SEM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10373512,ECO:0000269|PubMed:16205630;Dbxref=PMID:10373512,PMID:16205630
BRCA2	P51587	2777	2829	2481	2832	Region	Note=Interaction with SEM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10373512,ECO:0000269|PubMed:16205630;Dbxref=PMID:10373512,PMID:16205630
BRCA2	P51587	22	105	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA2	P51587	22	105	70	70	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA2	P51587	22	105	25	25	Natural variant	ID=VAR_028167;Note=In BC%3B abolishes interaction with PALB2. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16793542;Dbxref=PMID:16793542
BRCA2	P51587	22	105	25	25	Natural variant	ID=VAR_028167;Note=In BC%3B abolishes interaction with PALB2. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16793542;Dbxref=PMID:16793542
BRCA2	P51587	22	105	31	31	Natural variant	ID=VAR_028168;Note=In BC%3B abolishes interaction with PALB2. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16793542;Dbxref=PMID:16793542
BRCA2	P51587	22	105	31	31	Natural variant	ID=VAR_028168;Note=In BC%3B abolishes interaction with PALB2. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16793542;Dbxref=PMID:16793542
BRCA2	P51587	22	105	31	31	Natural variant	ID=VAR_028169;Note=In BC%3B abolishes interaction with PALB2. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16793542;Dbxref=PMID:16793542
BRCA2	P51587	22	105	31	31	Natural variant	ID=VAR_028169;Note=In BC%3B abolishes interaction with PALB2. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16793542;Dbxref=PMID:16793542
BRCA2	P51587	22	105	32	32	Natural variant	ID=VAR_005085;Note=In BC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=PMID:9609997
BRCA2	P51587	22	105	32	32	Natural variant	ID=VAR_005085;Note=In BC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=PMID:9609997
BRCA2	P51587	22	105	42	42	Natural variant	ID=VAR_020705;Note=In BC and ovarian cancer%3B unknown pathological significance. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12442275,ECO:0000269|PubMed:14746861;Dbxref=dbSNP:rs4987046,PMID:12442275,PMID:14746861
BRCA2	P51587	22	105	42	42	Natural variant	ID=VAR_020705;Note=In BC and ovarian cancer%3B unknown pathological significance. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12442275,ECO:0000269|PubMed:14746861;Dbxref=dbSNP:rs4987046,PMID:12442275,PMID:14746861
BRCA2	P51587	22	105	53	53	Natural variant	ID=VAR_005086;Note=In BC. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=PMID:9609997
BRCA2	P51587	22	105	53	53	Natural variant	ID=VAR_005086;Note=In BC. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=PMID:9609997
BRCA2	P51587	22	105	60	60	Natural variant	ID=VAR_020706;Note=In BC%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15026808;Dbxref=PMID:15026808
BRCA2	P51587	22	105	60	60	Natural variant	ID=VAR_020706;Note=In BC%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15026808;Dbxref=PMID:15026808
BRCA2	P51587	22	105	64	64	Natural variant	ID=VAR_032712;Note=In BC. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15172753;Dbxref=PMID:15172753
BRCA2	P51587	22	105	64	64	Natural variant	ID=VAR_032712;Note=In BC. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15172753;Dbxref=PMID:15172753
BRCA2	P51587	22	105	75	75	Natural variant	ID=VAR_005087;Note=In ovarian cancer and renal cancer%3B unknown pathological significance. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10486320;Dbxref=dbSNP:rs28897701,PMID:10486320
BRCA2	P51587	22	105	75	75	Natural variant	ID=VAR_005087;Note=In ovarian cancer and renal cancer%3B unknown pathological significance. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10486320;Dbxref=dbSNP:rs28897701,PMID:10486320
BRCA2	P51587	22	105	81	81	Natural variant	ID=VAR_005088;Note=In BC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=PMID:9609997
BRCA2	P51587	22	105	81	81	Natural variant	ID=VAR_005088;Note=In BC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=PMID:9609997
BRCA2	P51587	2280	2312	2293	2293	Natural variant	ID=VAR_020731;Note=In BC%3B unknown pathological significance. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442275;Dbxref=PMID:12442275
BRCA2	P51587	2280	2312	2293	2293	Natural variant	ID=VAR_020731;Note=In BC%3B unknown pathological significance. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442275;Dbxref=PMID:12442275
BRCA2	P51587	2777	2829	2787	2787	Natural variant	ID=VAR_008790;Note=In ovarian cancer%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8665505;Dbxref=PMID:8665505
BRCA2	P51587	2777	2829	2787	2787	Natural variant	ID=VAR_008790;Note=In ovarian cancer%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8665505;Dbxref=PMID:8665505
BRCA2	P51587	2777	2829	2792	2792	Natural variant	ID=VAR_056760;Note=L->P;Dbxref=dbSNP:rs28897751
BRCA2	P51587	2777	2829	2792	2792	Natural variant	ID=VAR_056760;Note=L->P;Dbxref=dbSNP:rs28897751
BRCA2	P51587	2777	2829	2793	2793	Natural variant	ID=VAR_020738;Note=In BC%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442275;Dbxref=PMID:12442275
BRCA2	P51587	2777	2829	2793	2793	Natural variant	ID=VAR_020738;Note=In BC%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442275;Dbxref=PMID:12442275
BRCA2	P51587	22	105	31	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU7
BRCA2	P51587	22	105	31	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EU7
BRIX1	Q8TDN6	170	187	1	353	Chain	ID=PRO_0000120230;Note=Ribosome biogenesis protein BRX1 homolog
BRIX1	Q8TDN6	221	264	1	353	Chain	ID=PRO_0000120230;Note=Ribosome biogenesis protein BRX1 homolog
BRIX1	Q8TDN6	170	187	60	249	Domain	Note=Brix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00034
BRIX1	Q8TDN6	221	264	60	249	Domain	Note=Brix;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00034
BRIX1	Q8TDN6	221	264	261	261	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BST1	Q10588	204	234	29	293	Chain	ID=PRO_0000004032;Note=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
BST1	Q10588	204	234	210	210	Site	Note=Crucial for NAD binding and catalysis
BST1	Q10588	204	234	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ISI
BST1	Q10588	204	234	205	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ISI
BST1	Q10588	204	234	211	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ISI
BST1	Q10588	204	234	216	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ISI
BST1	Q10588	204	234	219	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ISI
BTBD19	C9JJ37	118	138	1	291	Chain	ID=PRO_0000394239;Note=BTB/POZ domain-containing protein 19
BTBD19	C9JJ37	205	247	1	291	Chain	ID=PRO_0000394239;Note=BTB/POZ domain-containing protein 19
BTBD19	C9JJ37	118	138	134	234	Domain	Note=BACK
BTBD19	C9JJ37	205	247	134	234	Domain	Note=BACK
BTBD19	C9JJ37	205	247	139	291	Alternative sequence	ID=VSP_039226;Note=In isoform 2. VAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDEAELVRAARSWARVGAAVLERPVAEVAAPVVKELRLALLAPAELSALEEQNRQEPLIPVEQIVEAWKCHALRRGDEARGAPCRRRRGTLPREHHRFLDLSFK->HFWRPRRADQEVRRSRPSWLTRWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTBD8	Q5XKL5	50	115	1	378	Chain	ID=PRO_0000239224;Note=BTB/POZ domain-containing protein 8
BTBD8	Q5XKL5	50	115	58	127	Domain	Note=BTB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
BTBD8	Q5XKL5	50	115	60	60	Natural variant	ID=VAR_048436;Note=V->I;Dbxref=dbSNP:rs34856868
BTK	Q06187	259	279	2	659	Chain	ID=PRO_0000088065;Note=Tyrosine-protein kinase BTK
BTK	Q06187	259	279	214	274	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
BTK	Q06187	259	279	260	280	Natural variant	ID=VAR_006226;Note=In XLA%3B severe. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7849721;Dbxref=PMID:7849721
BTK	Q06187	259	279	257	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QLY
BTK	Q06187	259	279	261	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AWX
BTK	Q06187	259	279	266	268	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AWW
BTK	Q06187	259	279	279	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GE9
BTBD16	Q32M84	264	303	1	506	Chain	ID=PRO_0000247121;Note=BTB/POZ domain-containing protein 16
BTBD16	Q32M84	362	388	1	506	Chain	ID=PRO_0000247121;Note=BTB/POZ domain-containing protein 16
BTBD16	Q32M84	388	421	1	506	Chain	ID=PRO_0000247121;Note=BTB/POZ domain-containing protein 16
BTG3	Q14201	58	103	1	252	Chain	ID=PRO_0000143807;Note=Protein BTG3
BUB3	O43684	139	192	1	328	Chain	ID=PRO_0000050891;Note=Mitotic checkpoint protein BUB3
BUB3	O43684	139	192	129	164	Repeat	Note=WD 4
BUB3	O43684	139	192	170	210	Repeat	Note=WD 5
BUB3	O43684	139	192	179	179	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CCDC144A	A2RUR9	246	526	1	1427	Chain	ID=PRO_0000312279;Note=Coiled-coil domain-containing protein 144A
CCDC144A	A2RUR9	246	526	490	545	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC144A	A2RUR9	246	526	1	697	Alternative sequence	ID=VSP_029787;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9628581;Dbxref=PMID:9628581
CCDC144A	A2RUR9	246	526	247	526	Alternative sequence	ID=VSP_029788;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CWF19L1	Q69YN2	418	458	1	538	Chain	ID=PRO_0000315641;Note=CWF19-like protein 1
CWF19L1	Q69YN2	348	418	1	538	Chain	ID=PRO_0000315641;Note=CWF19-like protein 1
CWF19L1	Q69YN2	62	96	1	538	Chain	ID=PRO_0000315641;Note=CWF19-like protein 1
CWF19L1	Q69YN2	62	96	1	296	Alternative sequence	ID=VSP_030586;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CWF19L1	Q69YN2	62	96	1	137	Alternative sequence	ID=VSP_030587;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005
CWF19L1	Q69YN2	62	96	63	63	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD163	Q86VB7	1082	1114	42	1156	Chain	ID=PRO_0000238938;Note=Scavenger receptor cysteine-rich type 1 protein M130
CD163	Q86VB7	1042	1082	42	1156	Chain	ID=PRO_0000238938;Note=Scavenger receptor cysteine-rich type 1 protein M130
CD163	Q86VB7	926	1029	42	1156	Chain	ID=PRO_0000238938;Note=Scavenger receptor cysteine-rich type 1 protein M130
CD163	Q86VB7	683	714	42	1156	Chain	ID=PRO_0000238938;Note=Scavenger receptor cysteine-rich type 1 protein M130
CD163	Q86VB7	366	473	42	1156	Chain	ID=PRO_0000238938;Note=Scavenger receptor cysteine-rich type 1 protein M130
CD163	Q86VB7	1042	1082	42	1050	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	926	1029	42	1050	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	683	714	42	1050	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	366	473	42	1050	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	1042	1082	1051	1071	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	1082	1114	1072	1156	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	1042	1082	1072	1156	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163	Q86VB7	366	473	266	366	Domain	Note=SRCR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	366	473	373	473	Domain	Note=SRCR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	683	714	583	683	Domain	Note=SRCR 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	926	1029	824	926	Domain	Note=SRCR 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	926	1029	929	1029	Domain	Note=SRCR 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	1082	1114	1096	1099	Motif	Note=Internalization signal
CD163	Q86VB7	926	1029	1027	1027	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CD163	Q86VB7	366	473	398	462	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	366	473	411	472	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	366	473	442	452	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	926	1029	954	1018	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	926	1029	967	1028	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	926	1029	998	1008	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163	Q86VB7	1042	1082	1072	1072	Mutagenesis	Note=Impaired phosphorylation by PRKCA. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11298324;Dbxref=PMID:11298324
CD163	Q86VB7	1082	1114	1084	1084	Mutagenesis	Note=Impaired phosphorylation by PRKCA. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11298324;Dbxref=PMID:11298324
CD163	Q86VB7	1082	1114	1096	1096	Mutagenesis	Note=Massive decrease of endocytotic activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16434690;Dbxref=PMID:16434690
CDC42SE1	Q9NRR8	18	55	1	79	Chain	ID=PRO_0000334629;Note=CDC42 small effector protein 1
CDC42SE1	Q9NRR8	18	55	1	79	Chain	ID=PRO_0000334629;Note=CDC42 small effector protein 1
CDC42SE1	Q9NRR8	18	55	1	79	Chain	ID=PRO_0000334629;Note=CDC42 small effector protein 1
CDC42SE1	Q9NRR8	18	55	30	43	Domain	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057
CDC42SE1	Q9NRR8	18	55	30	43	Domain	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057
CDC42SE1	Q9NRR8	18	55	30	43	Domain	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057
CDC42SE1	Q9NRR8	18	55	19	24	Region	Note=Mediates phosphoinositide-binding
CDC42SE1	Q9NRR8	18	55	19	24	Region	Note=Mediates phosphoinositide-binding
CDC42SE1	Q9NRR8	18	55	19	24	Region	Note=Mediates phosphoinositide-binding
CDC42SE1	Q9NRR8	18	55	19	79	Alternative sequence	ID=VSP_033717;Note=In isoform 2. KKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL->VSLPTPHPNPKSSQLLCAVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11595176;Dbxref=PMID:11595176
CDC42SE1	Q9NRR8	18	55	19	79	Alternative sequence	ID=VSP_033717;Note=In isoform 2. KKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL->VSLPTPHPNPKSSQLLCAVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11595176;Dbxref=PMID:11595176
CDC42SE1	Q9NRR8	18	55	19	79	Alternative sequence	ID=VSP_033717;Note=In isoform 2. KKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL->VSLPTPHPNPKSSQLLCAVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11595176;Dbxref=PMID:11595176
CDC42SE1	Q9NRR8	18	55	33	33	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-38 and A-41. P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	33	33	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-38 and A-41. P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	33	33	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-38 and A-41. P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	38	38	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-33 and A-41. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	38	38	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-33 and A-41. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	38	38	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-33 and A-41. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	41	41	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-33 and A-38. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	41	41	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-33 and A-38. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
CDC42SE1	Q9NRR8	18	55	41	41	Mutagenesis	Note=Abolishes interaction with CDC42%2C induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR%3B when associated with A-33 and A-38. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10816584,ECO:0000269|PubMed:15840583;Dbxref=PMID:10816584,PMID:15840583
C1orf112	Q9NSG2	483	513	1	853	Chain	ID=PRO_0000279461;Note=Uncharacterized protein C1orf112
C1orf112	Q9NSG2	575	616	1	853	Chain	ID=PRO_0000279461;Note=Uncharacterized protein C1orf112
C1orf112	Q9NSG2	648	686	1	853	Chain	ID=PRO_0000279461;Note=Uncharacterized protein C1orf112
C1orf112	Q9NSG2	483	513	1	853	Chain	ID=PRO_0000279461;Note=Uncharacterized protein C1orf112
C1orf112	Q9NSG2	575	616	1	853	Chain	ID=PRO_0000279461;Note=Uncharacterized protein C1orf112
C1orf112	Q9NSG2	648	686	1	853	Chain	ID=PRO_0000279461;Note=Uncharacterized protein C1orf112
C1orf112	Q9NSG2	575	616	594	594	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
C1orf112	Q9NSG2	575	616	594	594	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
C1orf112	Q9NSG2	648	686	655	655	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
C1orf112	Q9NSG2	648	686	655	655	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPY19L4	Q7Z388	5	42	2	723	Chain	ID=PRO_0000311881;Note=Probable C-mannosyltransferase DPY19L4
DPY19L4	Q7Z388	245	290	2	723	Chain	ID=PRO_0000311881;Note=Probable C-mannosyltransferase DPY19L4
DPY19L4	Q7Z388	290	334	2	723	Chain	ID=PRO_0000311881;Note=Probable C-mannosyltransferase DPY19L4
DPY19L4	Q7Z388	334	367	2	723	Chain	ID=PRO_0000311881;Note=Probable C-mannosyltransferase DPY19L4
DPY19L4	Q7Z388	445	484	2	723	Chain	ID=PRO_0000311881;Note=Probable C-mannosyltransferase DPY19L4
DPY19L4	Q7Z388	245	290	260	280	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L4	Q7Z388	290	334	292	310	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L4	Q7Z388	290	334	316	337	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L4	Q7Z388	334	367	316	337	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L4	Q7Z388	334	367	349	370	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L4	Q7Z388	445	484	466	486	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	291	302	25	354	Chain	ID=PRO_0000004248;Note=Carbonic anhydrase 12
CA12	O43570	143	175	25	354	Chain	ID=PRO_0000004248;Note=Carbonic anhydrase 12
CA12	O43570	35	95	25	354	Chain	ID=PRO_0000004248;Note=Carbonic anhydrase 12
CA12	O43570	291	302	25	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	143	175	25	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	35	95	25	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	291	302	302	322	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	143	175	30	289	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA12	O43570	35	95	30	289	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA12	O43570	35	95	94	94	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00918
CA12	O43570	143	175	154	154	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00918
CA12	O43570	143	175	145	145	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11493685;Dbxref=PMID:11493685
CA12	O43570	35	95	80	80	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	143	175	162	162	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA12	O43570	143	175	50	230	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11493685;Dbxref=PMID:11493685
CA12	O43570	35	95	50	230	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11493685;Dbxref=PMID:11493685
CA12	O43570	291	302	292	302	Alternative sequence	ID=VSP_000772;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
CA12	O43570	143	175	143	143	Natural variant	ID=VAR_065292;Note=In HCHLH%3B mild reduction of activity%3B mutant enzyme is highly inhibited by acetazolamide and shows higher sensitivity to inhibition by anions compared to wild-type%3B the mutation affects the chloride-mediated negative feedback regulation of the enzyme leading to excessive chloride secretion in sweat. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21035102;Dbxref=dbSNP:rs267606694,PMID:21035102
CA12	O43570	35	95	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	40	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	48	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	52	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	65	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	75	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	85	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	35	95	93	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	143	175	141	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	143	175	151	153	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	143	175	157	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CA12	O43570	143	175	167	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MSA
CRAT	P43155	137	154	1	626	Chain	ID=PRO_0000210172;Note=Carnitine O-acetyltransferase
CRAT	P43155	137	154	132	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1NM8
CA5A	P35218	206	258	39	305	Chain	ID=PRO_0000004234;Note=Carbonic anhydrase 5A%2C mitochondrial
CA5A	P35218	185	206	39	305	Chain	ID=PRO_0000004234;Note=Carbonic anhydrase 5A%2C mitochondrial
CA5A	P35218	206	258	39	296	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5A	P35218	185	206	39	296	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5A	P35218	206	258	235	236	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
CA5A	P35218	206	258	233	233	Natural variant	ID=VAR_071188;Note=In CA5AD%3B reduced enzymatic activity. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24530203;Dbxref=dbSNP:rs587777316,PMID:24530203
CTSW	P56202	57	95	22	127	Propeptide	ID=PRO_0000026327;Ontology_term=ECO:0000255;evidence=ECO:0000255
CTSW	P56202	179	206	128	376	Chain	ID=PRO_0000026328;Note=Cathepsin W
CTSW	P56202	179	206	205	205	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CTSW	P56202	179	206	150	191	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSW	P56202	179	206	184	226	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSW	P56202	179	206	179	179	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSW	P56202	179	206	179	179	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSW	P56202	179	206	179	179	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
BNC2	Q6ZN30	43	110	1	1099	Chain	ID=PRO_0000046934;Note=Zinc finger protein basonuclin-2
BLNK	Q8WV28	365	417	1	456	Chain	ID=PRO_0000064940;Note=B-cell linker protein
BLNK	Q8WV28	202	225	1	456	Chain	ID=PRO_0000064940;Note=B-cell linker protein
BLNK	Q8WV28	365	417	346	453	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
BLNK	Q8WV28	202	225	98	260	Compositional bias	Note=Pro-rich
BLNK	Q8WV28	202	225	203	225	Alternative sequence	ID=VSP_016178;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9697839;Dbxref=PMID:9697839
BLNK	Q8WV28	365	417	366	417	Alternative sequence	ID=VSP_045324;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16636677;Dbxref=PMID:16636677
BPIFC	Q8NFQ6	326	383	24	507	Chain	ID=PRO_0000017166;Note=BPI fold-containing family C protein
BPIFC	Q8NFQ6	125	176	24	507	Chain	ID=PRO_0000017166;Note=BPI fold-containing family C protein
BPIFC	Q8NFQ6	326	383	24	507	Chain	ID=PRO_0000017166;Note=BPI fold-containing family C protein
BPIFC	Q8NFQ6	125	176	24	507	Chain	ID=PRO_0000017166;Note=BPI fold-containing family C protein
BPIFC	Q8NFQ6	326	383	355	355	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BPIFC	Q8NFQ6	326	383	355	355	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BPIFC	Q8NFQ6	326	383	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BPIFC	Q8NFQ6	326	383	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BPIFC	Q8NFQ6	125	176	161	200	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BPIFC	Q8NFQ6	125	176	161	200	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BPIFC	Q8NFQ6	125	176	1	186	Alternative sequence	ID=VSP_056033;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BPIFC	Q8NFQ6	125	176	1	186	Alternative sequence	ID=VSP_056033;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BPIFC	Q8NFQ6	326	383	327	383	Alternative sequence	ID=VSP_056034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BPIFC	Q8NFQ6	326	383	327	383	Alternative sequence	ID=VSP_056034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HLCS	P50747	332	393	1	726	Chain	ID=PRO_0000064979;Note=Biotin--protein ligase
HLCS	P50747	332	393	1	726	Chain	ID=PRO_0000064979;Note=Biotin--protein ligase
HLCS	P50747	332	393	333	333	Natural variant	ID=VAR_009196;Note=In HLCS deficiency%3B <10%25 activity%3B has normal or low KM values for biotin (non-KM mutant). V->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10190325,ECO:0000269|PubMed:10590022,ECO:0000269|PubMed:11735028;Dbxref=PMID:10190325,PMID:10590022,PMID:11735028
HLCS	P50747	332	393	333	333	Natural variant	ID=VAR_009196;Note=In HLCS deficiency%3B <10%25 activity%3B has normal or low KM values for biotin (non-KM mutant). V->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10190325,ECO:0000269|PubMed:10590022,ECO:0000269|PubMed:11735028;Dbxref=PMID:10190325,PMID:10590022,PMID:11735028
HLCS	P50747	332	393	360	360	Natural variant	ID=VAR_046508;Note=In HLCS deficiency%3B 22%25 activity%3B shows elevated KM values for biotin (KM mutant) compared with that of the wild-type form. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11735028;Dbxref=PMID:11735028
HLCS	P50747	332	393	360	360	Natural variant	ID=VAR_046508;Note=In HLCS deficiency%3B 22%25 activity%3B shows elevated KM values for biotin (KM mutant) compared with that of the wild-type form. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11735028;Dbxref=PMID:11735028
HLCS	P50747	332	393	363	363	Natural variant	ID=VAR_046509;Note=In HLCS deficiency%3B has normal or low KM values for biotin (non-KM mutant). V->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10590022,ECO:0000269|PubMed:8817339;Dbxref=dbSNP:rs769499327,PMID:10590022,PMID:8817339
HLCS	P50747	332	393	363	363	Natural variant	ID=VAR_046509;Note=In HLCS deficiency%3B has normal or low KM values for biotin (non-KM mutant). V->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10590022,ECO:0000269|PubMed:8817339;Dbxref=dbSNP:rs769499327,PMID:10590022,PMID:8817339
BPNT1	O95861	158	224	2	308	Chain	ID=PRO_0000142527;Note=3'(2')%2C5'-bisphosphate nucleotidase 1
BPNT1	O95861	75	111	2	308	Chain	ID=PRO_0000142527;Note=3'(2')%2C5'-bisphosphate nucleotidase 1
BPNT1	O95861	158	224	2	308	Chain	ID=PRO_0000142527;Note=3'(2')%2C5'-bisphosphate nucleotidase 1
BPNT1	O95861	75	111	2	308	Chain	ID=PRO_0000142527;Note=3'(2')%2C5'-bisphosphate nucleotidase 1
BPNT1	O95861	158	224	195	198	Region	Note=Substrate binding
BPNT1	O95861	158	224	195	198	Region	Note=Substrate binding
BPNT1	O95861	75	111	76	111	Alternative sequence	ID=VSP_054808;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BPNT1	O95861	75	111	76	111	Alternative sequence	ID=VSP_054808;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BPNT1	O95861	158	224	221	221	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
BPNT1	O95861	158	224	221	221	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
BPNT1	O95861	75	111	70	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	70	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	84	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	84	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	93	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	93	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	102	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	75	111	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	153	158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	153	158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	167	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	167	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	173	175	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	173	175	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	191	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	191	194	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	201	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	201	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	213	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	213	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	221	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BPNT1	O95861	158	224	221	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WEF
BRCA1	P38398	223	1365	1	1863	Chain	ID=PRO_0000055830;Note=Breast cancer type 1 susceptibility protein
BRCA1	P38398	45	70	1	1863	Chain	ID=PRO_0000055830;Note=Breast cancer type 1 susceptibility protein
BRCA1	P38398	27	44	1	1863	Chain	ID=PRO_0000055830;Note=Breast cancer type 1 susceptibility protein
BRCA1	P38398	45	70	24	65	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
BRCA1	P38398	27	44	24	65	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
BRCA1	P38398	223	1365	651	654	Compositional bias	Note=Poly-Lys
BRCA1	P38398	223	1365	308	308	Modified residue	Note=Phosphoserine%3B by AURKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14990569;Dbxref=PMID:14990569
BRCA1	P38398	223	1365	395	395	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
BRCA1	P38398	223	1365	398	398	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
BRCA1	P38398	223	1365	423	423	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
BRCA1	P38398	223	1365	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA1	P38398	223	1365	551	551	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA1	P38398	223	1365	694	694	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
BRCA1	P38398	223	1365	708	708	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA1	P38398	223	1365	725	725	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48754
BRCA1	P38398	223	1365	753	753	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
BRCA1	P38398	223	1365	840	840	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48754
BRCA1	P38398	223	1365	988	988	Modified residue	Note=Phosphoserine%3B by CHEK2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10724175,ECO:0000269|PubMed:20364141;Dbxref=PMID:10724175,PMID:20364141
BRCA1	P38398	223	1365	1009	1009	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA1	P38398	223	1365	1143	1143	Modified residue	Note=Phosphoserine%3B by ATR%3B in vitro;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	1189	1189	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA1	P38398	223	1365	1191	1191	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRCA1	P38398	223	1365	1211	1211	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
BRCA1	P38398	223	1365	1217	1217	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
BRCA1	P38398	223	1365	1218	1218	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
BRCA1	P38398	223	1365	1280	1280	Modified residue	Note=Phosphoserine%3B by ATR%3B in vitro;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	1328	1328	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
BRCA1	P38398	223	1365	1336	1336	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692
BRCA1	P38398	223	1365	1342	1342	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
BRCA1	P38398	223	1365	301	301	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRCA1	P38398	223	1365	339	339	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
BRCA1	P38398	223	1365	443	443	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
BRCA1	P38398	223	1365	459	459	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
BRCA1	P38398	223	1365	519	519	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRCA1	P38398	223	1365	583	583	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
BRCA1	P38398	223	1365	654	654	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
BRCA1	P38398	223	1365	734	734	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
BRCA1	P38398	223	1365	739	739	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
BRCA1	P38398	223	1365	918	918	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRCA1	P38398	223	1365	987	987	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRCA1	P38398	223	1365	1079	1079	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRCA1	P38398	45	70	1	47	Alternative sequence	ID=VSP_057569;Note=In isoform 8. Missing
BRCA1	P38398	27	44	1	47	Alternative sequence	ID=VSP_057569;Note=In isoform 8. Missing
BRCA1	P38398	223	1365	64	1863	Alternative sequence	ID=VSP_047891;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
BRCA1	P38398	45	70	64	1863	Alternative sequence	ID=VSP_047891;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
BRCA1	P38398	223	1365	224	1365	Alternative sequence	ID=VSP_035398;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BRCA1	P38398	223	1365	264	1366	Alternative sequence	ID=VSP_035399;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9010228;Dbxref=PMID:15489334,PMID:9010228
BRCA1	P38398	27	44	30	30	Natural variant	ID=VAR_035947;Note=In a breast cancer sample%3B somatic mutation. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
BRCA1	P38398	45	70	45	45	Natural variant	ID=VAR_070459;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs769650474,PMID:23867111
BRCA1	P38398	45	70	61	61	Natural variant	ID=VAR_007757;Note=In BC and ovarian cancer%3B no interaction with BAP1. C->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12938098,ECO:0000269|PubMed:14746861,ECO:0000269|PubMed:23867111,ECO:0000269|PubMed:7894493,ECO:0000269|PubMed:8554067,ECO:0000269|PubMed:9528852,ECO:0000269|PubMed:9760198;Dbxref=dbSNP:rs28897672,PMID:12938098,PMID:14746861,PMID:23867111,PMID:7894493,PMID:8554067,PMID:9528852,PMID:9760198
BRCA1	P38398	45	70	64	64	Natural variant	ID=VAR_007758;Note=In BC%3B no interaction with BAP1. C->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23867111,ECO:0000269|PubMed:7894491,ECO:0000269|PubMed:9482581,ECO:0000269|PubMed:9528852;Dbxref=dbSNP:rs80357064,PMID:23867111,PMID:7894491,PMID:9482581,PMID:9528852
BRCA1	P38398	45	70	64	64	Natural variant	ID=VAR_007759;Note=C->Y;Dbxref=dbSNP:rs55851803
BRCA1	P38398	45	70	67	67	Natural variant	ID=VAR_070460;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357102,PMID:23867111
BRCA1	P38398	223	1365	227	227	Natural variant	ID=VAR_008759;Note=In ovarian cancer%3B unknown pathological significance. E->K
BRCA1	P38398	223	1365	231	231	Natural variant	ID=VAR_070469;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357001,PMID:23867111
BRCA1	P38398	223	1365	239	239	Natural variant	ID=VAR_007760;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9010228,ECO:0000269|PubMed:9760198;Dbxref=dbSNP:rs80357396,PMID:9010228,PMID:9760198
BRCA1	P38398	223	1365	245	245	Natural variant	ID=VAR_070470;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80356865,PMID:23867111
BRCA1	P38398	223	1365	246	246	Natural variant	ID=VAR_070471;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs28897675,PMID:23867111
BRCA1	P38398	223	1365	271	271	Natural variant	ID=VAR_070472;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357244,PMID:23867111
BRCA1	P38398	223	1365	271	271	Natural variant	ID=VAR_007761;Note=In BC. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8723683;Dbxref=dbSNP:rs80357244,PMID:8723683
BRCA1	P38398	223	1365	275	275	Natural variant	ID=VAR_019944;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs8176153
BRCA1	P38398	223	1365	346	346	Natural variant	ID=VAR_008760;Note=In BC%3B unknown pathological significance. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10323242;Dbxref=dbSNP:rs80357015,PMID:10323242
BRCA1	P38398	223	1365	356	356	Natural variant	ID=VAR_007762;Note=Common polymorphism. Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7894493,ECO:0000269|Ref.5,ECO:0000269|Ref.6;Dbxref=dbSNP:rs1799950,PMID:7894493
BRCA1	P38398	223	1365	369	369	Natural variant	ID=VAR_007763;Note=In BC. Missing
BRCA1	P38398	223	1365	379	379	Natural variant	ID=VAR_007764;Note=I->M;Dbxref=dbSNP:rs56128296
BRCA1	P38398	223	1365	461	461	Natural variant	ID=VAR_007765;Note=In BC. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs56046357,PMID:9609997
BRCA1	P38398	223	1365	465	465	Natural variant	ID=VAR_007766;Note=In BC. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs397508869,PMID:9609997
BRCA1	P38398	223	1365	507	507	Natural variant	ID=VAR_007767;Note=Found in breast-ovarian cancer patients%3B unknown pathological significance. R->I;Dbxref=dbSNP:rs80357224
BRCA1	P38398	223	1365	552	552	Natural variant	ID=VAR_007768;Note=In BC. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs397508893,PMID:9609997
BRCA1	P38398	223	1365	656	656	Natural variant	ID=VAR_020682;Note=N->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442274;Dbxref=PMID:12442274
BRCA1	P38398	223	1365	668	668	Natural variant	ID=VAR_070473;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357250,PMID:23867111
BRCA1	P38398	223	1365	693	693	Natural variant	ID=VAR_007769;Note=Rare polymorphism. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15026808,ECO:0000269|Ref.6;Dbxref=dbSNP:rs4986850,PMID:15026808
BRCA1	P38398	223	1365	695	695	Natural variant	ID=VAR_070474;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs28897681,PMID:23867111
BRCA1	P38398	223	1365	723	723	Natural variant	ID=VAR_020110;Note=N->D;Dbxref=dbSNP:rs4986845
BRCA1	P38398	223	1365	749	749	Natural variant	ID=VAR_020683;Note=In BC. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12442275;Dbxref=dbSNP:rs80357114,PMID:12442275
BRCA1	P38398	223	1365	758	758	Natural variant	ID=VAR_035948;Note=In a breast cancer sample%3B somatic mutation. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
BRCA1	P38398	223	1365	772	772	Natural variant	ID=VAR_007770;Note=Rare polymorphism. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7894491,ECO:0000269|PubMed:9482581;Dbxref=dbSNP:rs80357467,PMID:7894491,PMID:9482581
BRCA1	P38398	223	1365	778	778	Natural variant	ID=VAR_035949;Note=In a breast cancer sample%3B somatic mutation. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
BRCA1	P38398	223	1365	798	798	Natural variant	ID=VAR_070475;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs876660005,PMID:23867111
BRCA1	P38398	223	1365	810	810	Natural variant	ID=VAR_070476;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs28897682,PMID:23867111
BRCA1	P38398	223	1365	820	820	Natural variant	ID=VAR_007771;Note=Rare polymorphism. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9482581;Dbxref=dbSNP:rs56082113,PMID:9482581
BRCA1	P38398	223	1365	826	826	Natural variant	ID=VAR_007772;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs28897683,PMID:23867111
BRCA1	P38398	223	1365	835	835	Natural variant	ID=VAR_020684;Note=In BROVCA1%3B unknown pathological significance. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12938098;Dbxref=dbSNP:rs751656678,PMID:12938098
BRCA1	P38398	223	1365	841	841	Natural variant	ID=VAR_070477;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357337,PMID:23867111
BRCA1	P38398	223	1365	841	841	Natural variant	ID=VAR_007773;Note=In BROVCA1%3B unknown pathological significance. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8968716,ECO:0000269|PubMed:9760198;Dbxref=dbSNP:rs1800709,PMID:8968716,PMID:9760198
BRCA1	P38398	223	1365	856	856	Natural variant	ID=VAR_020685;Note=In a patient with sporadic breast cancer%3B unknown pathological significance. Y->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15365993,ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80356892,PMID:15365993,PMID:23867111
BRCA1	P38398	223	1365	866	866	Natural variant	ID=VAR_070478;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs41286300,PMID:23867111
BRCA1	P38398	223	1365	866	866	Natural variant	ID=VAR_020686;Note=In BC%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12938098;Dbxref=PMID:12938098
BRCA1	P38398	223	1365	871	871	Natural variant	ID=VAR_007774;Note=Common polymorphism. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10323242,ECO:0000269|PubMed:12442274,ECO:0000269|PubMed:15365993,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.6;Dbxref=dbSNP:rs799917,PMID:10323242,PMID:12442274,PMID:15365993,PMID:15489334
BRCA1	P38398	223	1365	888	888	Natural variant	ID=VAR_020687;Note=In BC%3B unknown pathological significance. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12938098;Dbxref=dbSNP:rs80357480,PMID:12938098
BRCA1	P38398	223	1365	892	892	Natural variant	ID=VAR_007775;Note=In BC. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs397508994,PMID:9609997
BRCA1	P38398	223	1365	903	1863	Natural variant	ID=VAR_080693;Note=In FANCS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29133208;Dbxref=PMID:29133208
BRCA1	P38398	223	1365	925	925	Natural variant	ID=VAR_021913;Note=I->L;Dbxref=dbSNP:rs4986847
BRCA1	P38398	223	1365	960	960	Natural variant	ID=VAR_007776;Note=In BC. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs397509022,PMID:9609997
BRCA1	P38398	223	1365	989	989	Natural variant	ID=VAR_020111;Note=F->S;Dbxref=dbSNP:rs4986848
BRCA1	P38398	223	1365	1008	1008	Natural variant	ID=VAR_007777;Note=Common polymorphism. M->I;Dbxref=dbSNP:rs1800704
BRCA1	P38398	223	1365	1025	1025	Natural variant	ID=VAR_007778;Note=In BC. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs397509034,PMID:9609997
BRCA1	P38398	223	1365	1038	1038	Natural variant	ID=VAR_007779;Note=Common polymorphism. E->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10323242,ECO:0000269|PubMed:15365993,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7894493,ECO:0000269|Ref.6;Dbxref=dbSNP:rs16941,PMID:10323242,PMID:15365993,PMID:15489334,PMID:7894493
BRCA1	P38398	223	1365	1040	1040	Natural variant	ID=VAR_007780;Note=Rare polymorphism. S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15026808,ECO:0000269|PubMed:7894491,ECO:0000269|PubMed:7894493,ECO:0000269|PubMed:9482581,ECO:0000269|Ref.6;Dbxref=dbSNP:rs4986852,PMID:15026808,PMID:7894491,PMID:7894493,PMID:9482581
BRCA1	P38398	223	1365	1047	1047	Natural variant	ID=VAR_007781;Note=In BC. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9609997;Dbxref=dbSNP:rs397509037,PMID:9609997
BRCA1	P38398	223	1365	1060	1060	Natural variant	ID=VAR_020688;Note=E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15026808,ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357184,PMID:15026808,PMID:23867111
BRCA1	P38398	223	1365	1101	1101	Natural variant	ID=VAR_070479;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs41293447,PMID:23867111
BRCA1	P38398	223	1365	1139	1139	Natural variant	ID=VAR_020689;Note=In BC%3B unknown pathological significance. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12938098;Dbxref=dbSNP:rs80357228,PMID:12938098
BRCA1	P38398	223	1365	1140	1140	Natural variant	ID=VAR_019945;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. S->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23867111,ECO:0000269|Ref.6;Dbxref=dbSNP:rs2227945,PMID:23867111
BRCA1	P38398	223	1365	1140	1140	Natural variant	ID=VAR_070480;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=PMID:23867111
BRCA1	P38398	223	1365	1150	1150	Natural variant	ID=VAR_007782;Note=In BC. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8723683;Dbxref=dbSNP:rs80357272,PMID:8723683
BRCA1	P38398	223	1365	1183	1183	Natural variant	ID=VAR_007783;Note=Common polymorphism. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10323242,ECO:0000269|PubMed:14722926,ECO:0000269|PubMed:15365993,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7894493,ECO:0000269|Ref.6;Dbxref=dbSNP:rs16942,PMID:10323242,PMID:14722926,PMID:15365993,PMID:15489334,PMID:7894493
BRCA1	P38398	223	1365	1187	1187	Natural variant	ID=VAR_020690;Note=In BC and BROVCA1. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=PMID:14722926
BRCA1	P38398	223	1365	1200	1200	Natural variant	ID=VAR_020691;Note=In BC and BROVCA1. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=dbSNP:rs56214134,PMID:14722926
BRCA1	P38398	223	1365	1204	1204	Natural variant	ID=VAR_020692;Note=In BC. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=PMID:14722926
BRCA1	P38398	223	1365	1207	1207	Natural variant	ID=VAR_020693;Note=In BC. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=PMID:14722926
BRCA1	P38398	223	1365	1210	1210	Natural variant	ID=VAR_020694;Note=In BC%3B unknown pathological significance. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12938098;Dbxref=dbSNP:rs1060502347,PMID:12938098
BRCA1	P38398	223	1365	1214	1214	Natural variant	ID=VAR_070481;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80356923,PMID:23867111
BRCA1	P38398	223	1365	1217	1217	Natural variant	ID=VAR_020695;Note=In BC and BROVCA1. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=PMID:14722926
BRCA1	P38398	223	1365	1219	1219	Natural variant	ID=VAR_007784;Note=Found in breast-ovarian cancer patients%3B unknown pathological significance. E->D;Dbxref=dbSNP:rs80356876
BRCA1	P38398	223	1365	1226	1226	Natural variant	ID=VAR_020696;Note=In BROVCA1. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=PMID:14722926
BRCA1	P38398	223	1365	1236	1236	Natural variant	ID=VAR_052078;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs28897687,PMID:23867111
BRCA1	P38398	223	1365	1243	1243	Natural variant	ID=VAR_020697;Note=In BROVCA1. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14722926;Dbxref=PMID:14722926
BRCA1	P38398	223	1365	1250	1250	Natural variant	ID=VAR_052079;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs28897686,PMID:23867111
BRCA1	P38398	223	1365	1267	1267	Natural variant	ID=VAR_070482;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs587782190,PMID:23867111
BRCA1	P38398	223	1365	1282	1282	Natural variant	ID=VAR_070483;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357217,PMID:23867111
BRCA1	P38398	223	1365	1297	1297	Natural variant	ID=VAR_020698;Note=In BC%3B unknown pathological significance. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12938098;Dbxref=PMID:12938098
BRCA1	P38398	223	1365	1297	1297	Natural variant	ID=VAR_070484;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=PMID:23867111
BRCA1	P38398	223	1365	1301	1301	Natural variant	ID=VAR_070485;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs273900719,PMID:23867111
BRCA1	P38398	223	1365	1346	1346	Natural variant	ID=VAR_070486;Note=In BC%3B unknown pathological significance%3B functionally neutral in vitro. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23867111;Dbxref=dbSNP:rs80357407,PMID:23867111
BRCA1	P38398	223	1365	1347	1347	Natural variant	ID=VAR_007785;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12215251;Dbxref=dbSNP:rs28897689,PMID:12215251
BRCA1	P38398	223	1365	308	308	Mutagenesis	Note=Abolishes phosphorylation by AURKA and interferes with cell cycle progression from G2 to mitosis. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14990569;Dbxref=PMID:14990569
BRCA1	P38398	223	1365	1143	1143	Mutagenesis	Note=Reduces in vitro phosphorylation by ATR. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	1239	1239	Mutagenesis	Note=No effect on in vitro phosphorylation by ATR. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	1280	1280	Mutagenesis	Note=Reduces in vitro phosphorylation by ATR. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	1298	1298	Mutagenesis	Note=No effect on in vitro phosphorylation by ATR. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	1330	1330	Mutagenesis	Note=No effect on in vitro phosphorylation by ATR. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11114888;Dbxref=PMID:11114888
BRCA1	P38398	223	1365	253	253	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
BRCA1	P38398	223	1365	713	713	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BRCA1	P38398	223	1365	1077	1077	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
BRCA1	P38398	27	44	25	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JM7
BRCA1	P38398	45	70	46	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JM7
BRCA1	P38398	45	70	54	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JM7
BRCA1	P38398	45	70	62	64	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JM7
BRCA1	P38398	45	70	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JM7
BUD31	P41223	31	72	1	144	Chain	ID=PRO_0000193897;Note=Protein BUD31 homolog
BUD31	P41223	31	72	1	144	Chain	ID=PRO_0000193897;Note=Protein BUD31 homolog
BUD31	P41223	31	72	59	67	Region	Note=Interaction with AR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28076346;Dbxref=PMID:28076346
BUD31	P41223	31	72	59	67	Region	Note=Interaction with AR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28076346;Dbxref=PMID:28076346
BUD31	P41223	31	72	70	70	Sequence conflict	Note=I->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
BUD31	P41223	31	72	70	70	Sequence conflict	Note=I->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
BUD31	P41223	31	72	70	70	Sequence conflict	Note=I->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
BUD31	P41223	31	72	70	70	Sequence conflict	Note=I->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
BUD31	P41223	31	72	60	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OED
BUD31	P41223	31	72	60	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OED
C12orf57	Q99622	17	76	2	126	Chain	ID=PRO_0000065034;Note=Protein C10
C12orf57	Q99622	17	76	51	51	Natural variant	ID=VAR_069774;Note=In TEMTYS. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23453665;Dbxref=dbSNP:rs587776955,PMID:23453665
MTHFD1L	Q6UB35	104	121	32	978	Chain	ID=PRO_0000343177;Note=Monofunctional C1-tetrahydrofolate synthase%2C mitochondrial
MTHFD1L	Q6UB35	361	418	32	978	Chain	ID=PRO_0000343177;Note=Monofunctional C1-tetrahydrofolate synthase%2C mitochondrial
MTHFD1L	Q6UB35	601	648	32	978	Chain	ID=PRO_0000343177;Note=Monofunctional C1-tetrahydrofolate synthase%2C mitochondrial
MTHFD1L	Q6UB35	648	671	32	978	Chain	ID=PRO_0000343177;Note=Monofunctional C1-tetrahydrofolate synthase%2C mitochondrial
MTHFD1L	Q6UB35	104	121	31	348	Region	Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
MTHFD1L	Q6UB35	361	418	349	978	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1L	Q6UB35	601	648	349	978	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1L	Q6UB35	648	671	349	978	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1L	Q6UB35	361	418	276	978	Alternative sequence	ID=VSP_034566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12937168;Dbxref=PMID:12937168
MTHFD1L	Q6UB35	601	648	276	978	Alternative sequence	ID=VSP_034566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12937168;Dbxref=PMID:12937168
MTHFD1L	Q6UB35	648	671	276	978	Alternative sequence	ID=VSP_034566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12937168;Dbxref=PMID:12937168
CC2D1A	Q6P1N0	547	588	1	951	Chain	ID=PRO_0000239609;Note=Coiled-coil and C2 domain-containing protein 1A
CC2D1A	Q6P1N0	608	646	1	951	Chain	ID=PRO_0000239609;Note=Coiled-coil and C2 domain-containing protein 1A
CC2D1A	Q6P1N0	608	646	642	755	Domain	Note=C2
CC2D1A	Q6P1N0	608	646	635	635	Natural variant	ID=VAR_026671;Note=T->S;Dbxref=dbSNP:rs2290663
CC2D1A	Q6P1N0	608	646	646	646	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
C1orf54	Q8WWF1	15	43	1	16	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
C1orf54	Q8WWF1	15	43	1	16	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
C1orf54	Q8WWF1	15	43	17	131	Chain	ID=PRO_0000251200;Note=Uncharacterized protein C1orf54
C1orf54	Q8WWF1	15	43	17	131	Chain	ID=PRO_0000251200;Note=Uncharacterized protein C1orf54
C1orf94	Q6P1W5	482	508	1	598	Chain	ID=PRO_0000280097;Note=Uncharacterized protein C1orf94
C1orf198	Q9H425	128	309	2	327	Chain	ID=PRO_0000280342;Note=Uncharacterized protein C1orf198
C1orf198	Q9H425	128	309	129	129	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C3W1
C1orf198	Q9H425	128	309	175	175	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
C1orf198	Q9H425	128	309	289	289	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
C1orf198	Q9H425	128	309	1	130	Alternative sequence	ID=VSP_044252;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C1orf198	Q9H425	128	309	274	274	Natural variant	ID=VAR_050707;Note=A->S;Dbxref=dbSNP:rs34864456
C1orf198	Q9H425	128	309	306	306	Natural variant	ID=VAR_050708;Note=K->R;Dbxref=dbSNP:rs35115679
C1orf198	Q9H425	128	309	163	163	Sequence conflict	Note=Q->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNA2D2	Q9NY47	542	567	19	1150	Chain	ID=PRO_0000304637;Note=Voltage-dependent calcium channel subunit alpha-2/delta-2
CACNA2D2	Q9NY47	281	297	19	1150	Chain	ID=PRO_0000304637;Note=Voltage-dependent calcium channel subunit alpha-2/delta-2
CACNA2D2	Q9NY47	155	170	19	1150	Chain	ID=PRO_0000304637;Note=Voltage-dependent calcium channel subunit alpha-2/delta-2
CACNA2D2	Q9NY47	542	567	19	1001	Chain	ID=PRO_0000304638;Note=Voltage-dependent calcium channel subunit alpha-2-2;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D2	Q9NY47	281	297	19	1001	Chain	ID=PRO_0000304638;Note=Voltage-dependent calcium channel subunit alpha-2-2;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D2	Q9NY47	155	170	19	1001	Chain	ID=PRO_0000304638;Note=Voltage-dependent calcium channel subunit alpha-2-2;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D2	Q9NY47	542	567	19	1113	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D2	Q9NY47	281	297	19	1113	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D2	Q9NY47	155	170	19	1113	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D2	Q9NY47	281	297	291	469	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D2	Q9NY47	542	567	485	574	Domain	Note=Cache
CACNA2D2	Q9NY47	281	297	297	301	Motif	Note=MIDAS-like motif
CACNA2D2	Q9NY47	281	297	297	297	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D2	Q9NY47	542	567	443	1098	Disulfide bond	Note=Interchain (between alpha-2-2 and delta-2 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	68	107	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	181	225	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	296	321	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	351	389	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	542	570	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	852	873	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	68	107	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	181	225	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	296	321	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	351	389	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	542	570	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	852	873	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	68	107	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	181	225	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	296	321	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	351	389	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	542	570	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	852	873	29	1091	Chain	ID=PRO_0000304646;Note=Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D3	Q8IZS8	68	107	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	181	225	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	296	321	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	351	389	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	852	873	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	68	107	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	181	225	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	296	321	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	351	389	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	852	873	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	68	107	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	181	225	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	296	321	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	351	389	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	852	873	29	1068	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	296	321	256	438	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D3	Q8IZS8	351	389	256	438	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D3	Q8IZS8	296	321	256	438	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D3	Q8IZS8	351	389	256	438	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D3	Q8IZS8	296	321	256	438	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D3	Q8IZS8	351	389	256	438	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D3	Q8IZS8	542	570	452	549	Domain	Note=Cache
CACNA2D3	Q8IZS8	542	570	452	549	Domain	Note=Cache
CACNA2D3	Q8IZS8	542	570	452	549	Domain	Note=Cache
CACNA2D3	Q8IZS8	296	321	309	309	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	296	321	309	309	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	296	321	309	309	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D3	Q8IZS8	542	570	412	1055	Disulfide bond	Note=Interchain (between alpha-2-3 and delta-3 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	852	873	412	1055	Disulfide bond	Note=Interchain (between alpha-2-3 and delta-3 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	542	570	412	1055	Disulfide bond	Note=Interchain (between alpha-2-3 and delta-3 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	852	873	412	1055	Disulfide bond	Note=Interchain (between alpha-2-3 and delta-3 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	542	570	412	1055	Disulfide bond	Note=Interchain (between alpha-2-3 and delta-3 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	852	873	412	1055	Disulfide bond	Note=Interchain (between alpha-2-3 and delta-3 chains);Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D3	Q8IZS8	68	107	1	94	Alternative sequence	ID=VSP_028064;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11245980;Dbxref=PMID:11245980
CACNA2D3	Q8IZS8	68	107	1	94	Alternative sequence	ID=VSP_028064;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11245980;Dbxref=PMID:11245980
CACNA2D3	Q8IZS8	68	107	1	94	Alternative sequence	ID=VSP_028064;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11245980;Dbxref=PMID:11245980
CACNA2D3	Q8IZS8	852	873	620	1091	Alternative sequence	ID=VSP_028067;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11245980;Dbxref=PMID:11245980
CACNA2D3	Q8IZS8	852	873	620	1091	Alternative sequence	ID=VSP_028067;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11245980;Dbxref=PMID:11245980
CACNA2D3	Q8IZS8	852	873	620	1091	Alternative sequence	ID=VSP_028067;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11245980;Dbxref=PMID:11245980
CAB39	Q9Y376	189	209	1	341	Chain	ID=PRO_0000209824;Note=Calcium-binding protein 39
CAB39	Q9Y376	209	231	1	341	Chain	ID=PRO_0000209824;Note=Calcium-binding protein 39
CAB39	Q9Y376	189	209	1	341	Chain	ID=PRO_0000209824;Note=Calcium-binding protein 39
CAB39	Q9Y376	209	231	1	341	Chain	ID=PRO_0000209824;Note=Calcium-binding protein 39
CAB39	Q9Y376	189	209	1	341	Chain	ID=PRO_0000209824;Note=Calcium-binding protein 39
CAB39	Q9Y376	209	231	1	341	Chain	ID=PRO_0000209824;Note=Calcium-binding protein 39
CAB39	Q9Y376	189	209	178	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	178	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	178	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	196	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	196	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	196	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	209	231	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	209	231	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	189	209	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	209	231	207	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	209	231	223	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	209	231	223	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CAB39	Q9Y376	209	231	223	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UPK
CDH22	Q9UJ99	554	638	35	828	Chain	ID=PRO_0000003821;Note=Cadherin-22
CDH22	Q9UJ99	223	279	35	828	Chain	ID=PRO_0000003821;Note=Cadherin-22
CDH22	Q9UJ99	554	638	35	828	Chain	ID=PRO_0000003821;Note=Cadherin-22
CDH22	Q9UJ99	223	279	35	828	Chain	ID=PRO_0000003821;Note=Cadherin-22
CDH22	Q9UJ99	554	638	36	624	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	223	279	36	624	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	554	638	36	624	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	223	279	36	624	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	554	638	625	645	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	554	638	625	645	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	223	279	169	277	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH22	Q9UJ99	223	279	169	277	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH22	Q9UJ99	223	279	278	394	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH22	Q9UJ99	223	279	278	394	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH22	Q9UJ99	554	638	499	616	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH22	Q9UJ99	554	638	499	616	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH22	Q9UJ99	554	638	612	612	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH22	Q9UJ99	554	638	612	612	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNB4	O00305	372	434	1	520	Chain	ID=PRO_0000144060;Note=Voltage-dependent L-type calcium channel subunit beta-4
CACNB4	O00305	89	130	1	520	Chain	ID=PRO_0000144060;Note=Voltage-dependent L-type calcium channel subunit beta-4
CACNB4	O00305	89	130	92	161	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
CACNB4	O00305	372	434	411	411	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R0S4
CACNB4	O00305	372	434	373	434	Alternative sequence	ID=VSP_043193;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17618603;Dbxref=PMID:17618603
CACNB4	O00305	89	130	104	104	Natural variant	ID=VAR_013669;Note=In EA5%3B associated with susceptibility to EIG9. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10762541;Dbxref=dbSNP:rs1805031,PMID:10762541
CDH1	P12830	177	229	155	882	Chain	ID=PRO_0000003716;Note=Cadherin-1
CDH1	P12830	379	440	155	882	Chain	ID=PRO_0000003716;Note=Cadherin-1
CDH1	P12830	645	721	155	882	Chain	ID=PRO_0000003716;Note=Cadherin-1
CDH1	P12830	645	721	701	882	Chain	ID=PRO_0000236067;Note=E-Cad/CTF1
CDH1	P12830	177	229	155	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH1	P12830	379	440	155	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH1	P12830	645	721	155	709	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH1	P12830	645	721	710	730	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH1	P12830	177	229	155	262	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH1	P12830	379	440	376	486	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH1	P12830	645	721	594	697	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH1	P12830	645	721	700	701	Site	Note=Cleavage%3B by a metalloproteinase
CDH1	P12830	379	440	380	440	Alternative sequence	ID=VSP_055586;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
CDH1	P12830	177	229	193	193	Natural variant	ID=VAR_001307;Note=In a diffuse gastric cancer sample. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8797891;Dbxref=PMID:8797891
CDH1	P12830	379	440	393	393	Natural variant	ID=VAR_048501;Note=I->N;Dbxref=dbSNP:rs34466743
CDH1	P12830	379	440	400	400	Natural variant	ID=VAR_001312;Note=In a gastric carcinoma sample%3B loss of heterozygosity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9045944;Dbxref=PMID:9045944
CDH1	P12830	379	440	418	423	Natural variant	ID=VAR_001313;Note=In a gastric carcinoma sample. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9045944;Dbxref=PMID:9045944
CDH1	P12830	645	721	695	695	Natural variant	ID=VAR_021869;Note=C->R;Dbxref=dbSNP:rs9282655
CDH1	P12830	645	721	711	711	Natural variant	ID=VAR_001321;Note=Detected in an endometrial cancer sample. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8075649;Dbxref=dbSNP:rs121964871,PMID:8075649
CDH1	P12830	177	229	169	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	181	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	189	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	196	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	199	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	204	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	209	211	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	222	224	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH1	P12830	177	229	227	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OMZ
CDH2	P19022	182	234	160	906	Chain	ID=PRO_0000003732;Note=Cadherin-2
CDH2	P19022	182	234	160	724	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH2	P19022	182	234	160	267	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH2	P19022	182	234	190	190	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH2	P19022	182	234	196	196	Natural variant	ID=VAR_028256;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2216790;Dbxref=dbSNP:rs1041970,PMID:2216790
CDH2	P19022	182	234	212	212	Natural variant	ID=VAR_028257;Note=I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2384753;Dbxref=dbSNP:rs1041972,PMID:2384753
CACNA1E	Q15878	747	765	1	2313	Chain	ID=PRO_0000053938;Note=Voltage-dependent R-type calcium channel subunit alpha-1E
CACNA1E	Q15878	1605	1627	1	2313	Chain	ID=PRO_0000053938;Note=Voltage-dependent R-type calcium channel subunit alpha-1E
CACNA1E	Q15878	1823	1859	1	2313	Chain	ID=PRO_0000053938;Note=Voltage-dependent R-type calcium channel subunit alpha-1E
CACNA1E	Q15878	1966	2009	1	2313	Chain	ID=PRO_0000053938;Note=Voltage-dependent R-type calcium channel subunit alpha-1E
CACNA1E	Q15878	747	765	704	1148	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1E	Q15878	1605	1627	1591	1609	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1E	Q15878	1605	1627	1610	1629	Transmembrane	Note=Helical%3B Name%3DS5 of repeat IV
CACNA1E	Q15878	1823	1859	1725	2313	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1E	Q15878	1966	2009	1725	2313	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1E	Q15878	1605	1627	1463	1726	Repeat	Note=IV
CACNA1E	Q15878	747	765	748	753	Compositional bias	Note=Poly-Arg
CACNA1E	Q15878	747	765	748	766	Alternative sequence	ID=VSP_000937;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8071363;Dbxref=PMID:8071363
CACNA1E	Q15878	1966	2009	1967	2009	Alternative sequence	ID=VSP_024817;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8071363;Dbxref=PMID:8071363
DAAM1	Q9Y4D1	91	115	1	1078	Chain	ID=PRO_0000194907;Note=Disheveled-associated activator of morphogenesis 1
DAAM1	Q9Y4D1	656	666	1	1078	Chain	ID=PRO_0000194907;Note=Disheveled-associated activator of morphogenesis 1
DAAM1	Q9Y4D1	91	115	45	420	Domain	Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579
DAAM1	Q9Y4D1	656	666	600	1009	Domain	Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774
DAAM1	Q9Y4D1	656	666	656	665	Alternative sequence	ID=VSP_008000;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CALR3	Q96L12	64	132	20	384	Chain	ID=PRO_0000004178;Note=Calreticulin-3
CALR3	Q96L12	64	132	20	197	Region	Note=N-domain
CALR3	Q96L12	64	132	109	109	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR3	Q96L12	64	132	111	111	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR3	Q96L12	64	132	128	128	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR3	Q96L12	64	132	105	137	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR3	Q96L12	64	132	82	82	Natural variant	ID=VAR_065476;Note=In CMH19. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17655857;Dbxref=dbSNP:rs142951029,PMID:17655857
CAPN12	Q6ZSI9	605	626	1	719	Chain	ID=PRO_0000207730;Note=Calpain-12
CAPN12	Q6ZSI9	542	562	1	719	Chain	ID=PRO_0000207730;Note=Calpain-12
CAPN12	Q6ZSI9	605	626	620	655	Domain	Note=EF-hand;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN12	Q6ZSI9	605	626	541	719	Region	Note=Domain IV
CAPN12	Q6ZSI9	542	562	541	719	Region	Note=Domain IV
CAMSAP2	Q08AD1	133	187	1	1489	Chain	ID=PRO_0000316832;Note=Calmodulin-regulated spectrin-associated protein 2
CAMSAP2	Q08AD1	215	226	1	1489	Chain	ID=PRO_0000316832;Note=Calmodulin-regulated spectrin-associated protein 2
CAMSAP2	Q08AD1	215	226	222	335	Domain	Note=Calponin-homology (CH);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00044
CAMSAP2	Q08AD1	215	226	216	226	Alternative sequence	ID=VSP_030805;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAMSAP2	Q08AD1	133	187	150	150	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
B4GALT7	Q9UBV7	213	241	1	327	Chain	ID=PRO_0000080550;Note=Beta-1%2C4-galactosyltransferase 7
B4GALT7	Q9UBV7	241	276	1	327	Chain	ID=PRO_0000080550;Note=Beta-1%2C4-galactosyltransferase 7
B4GALT7	Q9UBV7	213	241	52	327	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT7	Q9UBV7	241	276	52	327	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT7	Q9UBV7	213	241	226	229	Region	Note=N-acetyl-D-glucosamine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
B4GALT7	Q9UBV7	241	276	257	259	Region	Note=UDP-alpha-D-galactose binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4IRQ,ECO:0000269|PubMed:24052259;Dbxref=PMID:24052259
B4GALT7	Q9UBV7	241	276	257	257	Metal binding	Note=Manganese%3B via tele nitrogen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4IRP,ECO:0000244|PDB:4IRQ,ECO:0000269|PubMed:24052259;Dbxref=PMID:24052259
B4GALT7	Q9UBV7	213	241	224	224	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4IRQ,ECO:0000269|PubMed:24052259;Dbxref=PMID:24052259
B4GALT7	Q9UBV7	241	276	266	266	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4IRQ,ECO:0000269|PubMed:24052259;Dbxref=PMID:24052259
B4GALT7	Q9UBV7	213	241	208	213	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRP
B4GALT7	Q9UBV7	213	241	223	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRQ
B4GALT7	Q9UBV7	213	241	227	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRP
B4GALT7	Q9UBV7	241	276	251	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRQ
B4GALT7	Q9UBV7	241	276	254	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRP
B4GALT7	Q9UBV7	241	276	261	263	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRQ
B4GALT7	Q9UBV7	241	276	274	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IRQ
BAG4	O95429	90	126	1	457	Chain	ID=PRO_0000088870;Note=BAG family molecular chaperone regulator 4
BAG4	O95429	126	211	1	457	Chain	ID=PRO_0000088870;Note=BAG family molecular chaperone regulator 4
BAG4	O95429	90	126	108	108	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
BAG4	O95429	126	211	185	185	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
BAG4	O95429	90	126	90	125	Alternative sequence	ID=VSP_042741;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BBIP1	A8MTZ0	12	37	1	92	Chain	ID=PRO_0000342378;Note=BBSome-interacting protein 1
BBIP1	A8MTZ0	12	37	1	92	Chain	ID=PRO_0000342378;Note=BBSome-interacting protein 1
BBIP1	A8MTZ0	12	37	1	22	Alternative sequence	ID=VSP_045981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BBIP1	A8MTZ0	12	37	1	22	Alternative sequence	ID=VSP_045981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BBIP1	A8MTZ0	12	37	14	92	Alternative sequence	ID=VSP_046433;Note=In isoform 4. KNTISNNSDMAEVKSMFREVLPKQGPLFVEDIMTMVLCKPKLLPLKSLTLEKLEKMHQAAQNTIRQQEMAEKDQRQITH->LLKFNNYGILSESPLTSQRTTWLLYQSPSFIPGFAYPSRCLKTIGGVYKQARKKHYIQQLRYGRSEVNVPGSSSKARATVCGRYNDNGAV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BBIP1	A8MTZ0	12	37	14	92	Alternative sequence	ID=VSP_046433;Note=In isoform 4. KNTISNNSDMAEVKSMFREVLPKQGPLFVEDIMTMVLCKPKLLPLKSLTLEKLEKMHQAAQNTIRQQEMAEKDQRQITH->LLKFNNYGILSESPLTSQRTTWLLYQSPSFIPGFAYPSRCLKTIGGVYKQARKKHYIQQLRYGRSEVNVPGSSSKARATVCGRYNDNGAV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BBIP1	A8MTZ0	12	37	14	38	Alternative sequence	ID=VSP_046434;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BBIP1	A8MTZ0	12	37	14	38	Alternative sequence	ID=VSP_046434;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BBS2	Q9BXC9	553	599	1	721	Chain	ID=PRO_0000064843;Note=Bardet-Biedl syndrome 2 protein
BBS2	Q9BXC9	204	239	1	721	Chain	ID=PRO_0000064843;Note=Bardet-Biedl syndrome 2 protein
BBS2	Q9BXC9	115	157	1	721	Chain	ID=PRO_0000064843;Note=Bardet-Biedl syndrome 2 protein
BBS2	Q9BXC9	39	115	1	721	Chain	ID=PRO_0000064843;Note=Bardet-Biedl syndrome 2 protein
BBS2	Q9BXC9	39	115	70	70	Natural variant	ID=VAR_013162;Note=In BBS2. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11567139;Dbxref=dbSNP:rs4784677,PMID:11567139
BBS2	Q9BXC9	39	115	75	75	Natural variant	ID=VAR_013163;Note=In BBS2%3B in linkage disequilibrium with V-123 in a Bedouin kindred. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11285252;Dbxref=PMID:11285252
BBS2	Q9BXC9	39	115	81	81	Natural variant	ID=VAR_066280;Note=In BBS2. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21344540;Dbxref=PMID:21344540
BBS2	Q9BXC9	39	115	104	104	Natural variant	ID=VAR_013164;Note=In BBS2 and RP74. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11567139,ECO:0000269|PubMed:21344540,ECO:0000269|PubMed:25541840;Dbxref=PMID:11567139,PMID:21344540,PMID:25541840
BBS2	Q9BXC9	115	157	122	122	Natural variant	ID=VAR_029747;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856449,PMID:15489334
BBS2	Q9BXC9	115	157	123	123	Natural variant	ID=VAR_013165;Note=Polymorphism in linkage disequilibrium with G-75 in a Bedouin kindred. I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11285252,ECO:0000269|PubMed:15666242,ECO:0000269|PubMed:15770229;Dbxref=dbSNP:rs11373,PMID:11285252,PMID:15666242,PMID:15770229
BBS2	Q9BXC9	115	157	125	125	Natural variant	ID=VAR_066281;Note=In BBS2. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21344540;Dbxref=PMID:21344540
BBS2	Q9BXC9	115	157	134	134	Natural variant	ID=VAR_075727;Note=In RP74. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25541840;Dbxref=PMID:25541840
BBS2	Q9BXC9	115	157	136	136	Natural variant	ID=VAR_066282;Note=In BBS2. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21344540;Dbxref=PMID:21344540
BBS2	Q9BXC9	115	157	139	139	Natural variant	ID=VAR_075728;Note=In BBS2. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16823392;Dbxref=PMID:16823392
BBS2	Q9BXC9	553	599	558	558	Natural variant	ID=VAR_013168;Note=In BBS2. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11567139;Dbxref=PMID:11567139
BBS2	Q9BXC9	39	115	63	63	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BBS7	Q8IWZ6	504	558	1	715	Chain	ID=PRO_0000064846;Note=Bardet-Biedl syndrome 7 protein
BBS7	Q8IWZ6	410	435	1	715	Chain	ID=PRO_0000064846;Note=Bardet-Biedl syndrome 7 protein
BCAS1	O75363	450	472	1	584	Chain	ID=PRO_0000064859;Note=Breast carcinoma-amplified sequence 1
BCAS1	O75363	394	450	1	584	Chain	ID=PRO_0000064859;Note=Breast carcinoma-amplified sequence 1
BCAS1	O75363	380	394	1	584	Chain	ID=PRO_0000064859;Note=Breast carcinoma-amplified sequence 1
BCAS1	O75363	380	394	381	381	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80YN3
BCAS1	O75363	394	450	399	399	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80YN3
BCAS1	O75363	394	450	381	394	Alternative sequence	ID=VSP_018521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10857754,ECO:0000303|PubMed:17974005;Dbxref=PMID:10857754,PMID:17974005
BCAS1	O75363	380	394	381	394	Alternative sequence	ID=VSP_018521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10857754,ECO:0000303|PubMed:17974005;Dbxref=PMID:10857754,PMID:17974005
BCAS1	O75363	450	472	451	472	Alternative sequence	ID=VSP_018522;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10857754,ECO:0000303|PubMed:17974005;Dbxref=PMID:10857754,PMID:17974005
BCAS1	O75363	450	472	472	472	Natural variant	ID=VAR_050691;Note=Q->H;Dbxref=dbSNP:rs35575210
BHLHE41	Q9C0J9	42	78	1	482	Chain	ID=PRO_0000127147;Note=Class E basic helix-loop-helix protein 41
BHLHE41	Q9C0J9	42	78	44	99	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
BHLHE41	Q9C0J9	42	78	67	71	Region	Note=Necessary for interaction with RXRA and repressor activity towards RXRA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19786558;Dbxref=PMID:19786558
BHLHE41	Q9C0J9	42	78	70	71	Mutagenesis	Note=Abolishes RXRA repression. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19786558;Dbxref=PMID:19786558
CDCA8	Q53HL2	163	194	1	280	Chain	ID=PRO_0000247075;Note=Borealin
CDCA8	Q53HL2	237	266	1	280	Chain	ID=PRO_0000247075;Note=Borealin
CDCA8	Q53HL2	163	194	1	280	Chain	ID=PRO_0000247075;Note=Borealin
CDCA8	Q53HL2	237	266	1	280	Chain	ID=PRO_0000247075;Note=Borealin
CDCA8	Q53HL2	163	194	165	165	Modified residue	Note=Phosphoserine%3B by AURKB;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15249581;Dbxref=PMID:15249581
CDCA8	Q53HL2	163	194	165	165	Modified residue	Note=Phosphoserine%3B by AURKB;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15249581;Dbxref=PMID:15249581
CDCA8	Q53HL2	163	194	169	169	Modified residue	Note=Phosphothreonine%3B by TTK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19530738;Dbxref=PMID:19530738
CDCA8	Q53HL2	163	194	169	169	Modified residue	Note=Phosphothreonine%3B by TTK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19530738;Dbxref=PMID:19530738
CDCA8	Q53HL2	163	194	189	189	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:23186163
CDCA8	Q53HL2	163	194	189	189	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:20068231,PMID:23186163
CDCA8	Q53HL2	237	266	238	238	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19530738;Dbxref=PMID:19530738
CDCA8	Q53HL2	237	266	238	238	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19530738;Dbxref=PMID:19530738
CDCA8	Q53HL2	237	266	244	244	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
CDCA8	Q53HL2	237	266	244	244	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
CDCA8	Q53HL2	163	194	165	165	Mutagenesis	Note=Results in reduction but not abolition of phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15249581;Dbxref=PMID:15249581
CDCA8	Q53HL2	163	194	165	165	Mutagenesis	Note=Results in reduction but not abolition of phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15249581;Dbxref=PMID:15249581
CDCA8	Q53HL2	163	194	169	169	Mutagenesis	Note=Decrease in AURKB activity and almost no phosphorylation by TTK%3B when associated with A-88%3B A-94 and A-230. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19530738;Dbxref=PMID:19530738
CDCA8	Q53HL2	163	194	169	169	Mutagenesis	Note=Decrease in AURKB activity and almost no phosphorylation by TTK%3B when associated with A-88%3B A-94 and A-230. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19530738;Dbxref=PMID:19530738
CDCA8	Q53HL2	163	194	171	171	Mutagenesis	Note=Decreases interaction with SOG1 and SOG2%2C abolishes localization to centromeres in prometaphase%3B when associated with A-106%2C A-185%2C A-189%2C A-199%2C A-204 and A-219. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739936;Dbxref=PMID:20739936
CDCA8	Q53HL2	163	194	171	171	Mutagenesis	Note=Decreases interaction with SOG1 and SOG2%2C abolishes localization to centromeres in prometaphase%3B when associated with A-106%2C A-185%2C A-189%2C A-199%2C A-204 and A-219. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739936;Dbxref=PMID:20739936
CDCA8	Q53HL2	163	194	185	185	Mutagenesis	Note=Decreases interaction with SOG1 and SOG2%2C abolishes localization to centromeres in prometaphase%3B when associated with A-106%2C A-171%2C A-189%2C A-199%2C A-204 and A-219. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739936;Dbxref=PMID:20739936
CDCA8	Q53HL2	163	194	185	185	Mutagenesis	Note=Decreases interaction with SOG1 and SOG2%2C abolishes localization to centromeres in prometaphase%3B when associated with A-106%2C A-171%2C A-189%2C A-199%2C A-204 and A-219. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739936;Dbxref=PMID:20739936
CDCA8	Q53HL2	163	194	189	189	Mutagenesis	Note=Decreases interaction with SOG1 and SOG2%2C abolishes localization to centromeres in prometaphase%3B when associated with A-106%2C A-171%2C A-185%2C A-199%2C A-204 and A-219. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739936;Dbxref=PMID:20739936
CDCA8	Q53HL2	163	194	189	189	Mutagenesis	Note=Decreases interaction with SOG1 and SOG2%2C abolishes localization to centromeres in prometaphase%3B when associated with A-106%2C A-171%2C A-185%2C A-199%2C A-204 and A-219. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20739936;Dbxref=PMID:20739936
CDCA8	Q53HL2	237	266	233	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	233	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	243	245	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	243	245	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	248	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	248	252	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	256	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CDCA8	Q53HL2	237	266	256	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KDD
CYTL1	Q9NRR1	66	109	23	136	Chain	ID=PRO_0000020838;Note=Cytokine-like protein 1
CDH19	Q9H159	525	609	44	772	Chain	ID=PRO_0000003818;Note=Cadherin-19
CDH19	Q9H159	203	258	44	772	Chain	ID=PRO_0000003818;Note=Cadherin-19
CDH19	Q9H159	525	609	44	596	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH19	Q9H159	203	258	44	596	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH19	Q9H159	525	609	597	617	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH19	Q9H159	203	258	149	256	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH19	Q9H159	203	258	257	370	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH19	Q9H159	525	609	470	581	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH19	Q9H159	525	609	534	534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH19	Q9H159	525	609	491	772	Alternative sequence	ID=VSP_047021;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BLOC1S2	Q6QNY1	57	97	2	142	Chain	ID=PRO_0000234543;Note=Biogenesis of lysosome-related organelles complex 1 subunit 2
BLOC1S2	Q6QNY1	18	57	2	142	Chain	ID=PRO_0000234543;Note=Biogenesis of lysosome-related organelles complex 1 subunit 2
BLOC1S2	Q6QNY1	57	97	79	127	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BLOC1S2	Q6QNY1	18	57	1	43	Alternative sequence	ID=VSP_018350;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15381421;Dbxref=PMID:15381421
BMP7	P18075	253	319	30	292	Propeptide	ID=PRO_0000033876;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17977014;Dbxref=PMID:17977014
BMP7	P18075	345	382	293	431	Chain	ID=PRO_0000033877;Note=Bone morphogenetic protein 7
BMP7	P18075	253	319	293	431	Chain	ID=PRO_0000033877;Note=Bone morphogenetic protein 7
BMP7	P18075	253	319	302	302	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMP7	P18075	345	382	372	372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMP7	P18075	345	382	330	396	Disulfide bond	.
BMP7	P18075	345	382	359	428	Disulfide bond	.
BMP7	P18075	345	382	363	430	Disulfide bond	.
BMP7	P18075	345	382	345	347	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LXI
BMP7	P18075	345	382	348	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LXI
BMP7	P18075	345	382	352	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LXI
BMP7	P18075	345	382	358	362	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LXI
BMP7	P18075	345	382	365	368	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M4U
BMP7	P18075	345	382	369	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LXI
BMP7	P18075	345	382	375	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LXI
BOLL	Q8N9W6	160	184	1	283	Chain	ID=PRO_0000081494;Note=Protein boule-like
BOLL	Q8N9W6	160	184	1	283	Chain	ID=PRO_0000081494;Note=Protein boule-like
BOLL	Q8N9W6	160	184	164	194	Domain	Note=DAZ-like
BOLL	Q8N9W6	160	184	164	194	Domain	Note=DAZ-like
BOLL	Q8N9W6	160	184	184	184	Alternative sequence	ID=VSP_009445;Note=In isoform 2. Q->QGIKQCHTRRWMDSLLPFTKCDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BOLL	Q8N9W6	160	184	184	184	Alternative sequence	ID=VSP_009445;Note=In isoform 2. Q->QGIKQCHTRRWMDSLLPFTKCDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BOLL	Q8N9W6	160	184	164	164	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
BOLL	Q8N9W6	160	184	164	164	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
BMS1	Q14692	149	212	1	1282	Chain	ID=PRO_0000195004;Note=Ribosome biogenesis protein BMS1 homolog
BMS1	Q14692	860	923	1	1282	Chain	ID=PRO_0000195004;Note=Ribosome biogenesis protein BMS1 homolog
BMS1	Q14692	1003	1044	1	1282	Chain	ID=PRO_0000195004;Note=Ribosome biogenesis protein BMS1 homolog
BMS1	Q14692	149	212	80	246	Domain	Note=Bms1-type G
BMS1	Q14692	149	212	188	188	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BMS1	Q14692	860	923	884	884	Natural variant	ID=VAR_057506;Note=M->V;Dbxref=dbSNP:rs2419109
BPIFA1	Q9NP55	107	142	20	256	Chain	ID=PRO_0000017175;Note=BPI fold-containing family A member 1
BPIFA1	Q9NP55	143	193	20	256	Chain	ID=PRO_0000017175;Note=BPI fold-containing family A member 1
BPIFA1	Q9NP55	107	142	20	256	Chain	ID=PRO_0000017175;Note=BPI fold-containing family A member 1
BPIFA1	Q9NP55	143	193	20	256	Chain	ID=PRO_0000017175;Note=BPI fold-containing family A member 1
BPIFA1	Q9NP55	107	142	20	256	Chain	ID=PRO_0000017175;Note=BPI fold-containing family A member 1
BPIFA1	Q9NP55	143	193	20	256	Chain	ID=PRO_0000017175;Note=BPI fold-containing family A member 1
BPIFA1	Q9NP55	143	193	180	224	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24043776;Dbxref=PMID:24043776
BPIFA1	Q9NP55	143	193	180	224	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24043776;Dbxref=PMID:24043776
BPIFA1	Q9NP55	143	193	180	224	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24043776;Dbxref=PMID:24043776
BPIFA1	Q9NP55	107	142	109	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	109	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	109	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	119	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	119	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	119	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	124	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KGO
BPIFA1	Q9NP55	107	142	124	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KGO
BPIFA1	Q9NP55	107	142	124	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KGO
BPIFA1	Q9NP55	107	142	129	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	129	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	107	142	129	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I7J
BPIFA1	Q9NP55	143	193	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I7J
BPIFA1	Q9NP55	143	193	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I7J
BPIFA1	Q9NP55	143	193	152	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	152	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	152	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	173	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	173	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	173	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	184	186	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N4X
BPIFA1	Q9NP55	143	193	184	186	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N4X
BPIFA1	Q9NP55	143	193	184	186	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4N4X
BPIFA1	Q9NP55	143	193	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KEG
BPIFA1	Q9NP55	143	193	193	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I7J
BPIFA1	Q9NP55	143	193	193	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I7J
BPIFA1	Q9NP55	143	193	193	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I7J
TBC1D32	Q96NH3	924	966	1	1257	Chain	ID=PRO_0000089557;Note=Protein broad-minded
TBC1D32	Q96NH3	360	380	1	1257	Chain	ID=PRO_0000089557;Note=Protein broad-minded
TBC1D32	Q96NH3	188	230	1	1257	Chain	ID=PRO_0000089557;Note=Protein broad-minded
TBC1D32	Q96NH3	924	966	109	1257	Alternative sequence	ID=VSP_035580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D32	Q96NH3	360	380	109	1257	Alternative sequence	ID=VSP_035580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D32	Q96NH3	188	230	109	1257	Alternative sequence	ID=VSP_035580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TBC1D32	Q96NH3	360	380	375	375	Natural variant	ID=VAR_046960;Note=T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs9387944,PMID:14702039
BRD4	O60885	95	141	1	1362	Chain	ID=PRO_0000211183;Note=Bromodomain-containing protein 4
BRD4	O60885	95	141	75	147	Domain	Note=Bromo 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
BRD4	O60885	95	141	140	140	Binding site	Note=Acetylated histones;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22464331;Dbxref=PMID:22464331
BRD4	O60885	95	141	140	140	Binding site	Note=Inhibitor
BRD4	O60885	95	141	99	99	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRD4	O60885	95	141	140	140	Mutagenesis	Note=Abolishes binding to acetylated histones. N->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22464331,ECO:0000269|PubMed:23728299;Dbxref=PMID:22464331,PMID:23728299
BRD4	O60885	95	141	97	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QB3
BRD4	O60885	95	141	107	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QB3
BRD4	O60885	95	141	122	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QB3
BRD8	Q9H0E9	844	859	1	1235	Chain	ID=PRO_0000211185;Note=Bromodomain-containing protein 8
BRD8	Q9H0E9	727	749	1	1235	Chain	ID=PRO_0000211185;Note=Bromodomain-containing protein 8
BRD8	Q9H0E9	696	726	1	1235	Chain	ID=PRO_0000211185;Note=Bromodomain-containing protein 8
BRD8	Q9H0E9	426	577	1	1235	Chain	ID=PRO_0000211185;Note=Bromodomain-containing protein 8
BRD8	Q9H0E9	262	332	1	1235	Chain	ID=PRO_0000211185;Note=Bromodomain-containing protein 8
BRD8	Q9H0E9	120	146	1	1235	Chain	ID=PRO_0000211185;Note=Bromodomain-containing protein 8
BRD8	Q9H0E9	727	749	724	794	Domain	Note=Bromo 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
BRD8	Q9H0E9	696	726	724	794	Domain	Note=Bromo 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
BRD8	Q9H0E9	120	146	97	171	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BRD8	Q9H0E9	426	577	481	481	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
BRD8	Q9H0E9	426	577	469	469	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRD8	Q9H0E9	426	577	481	481	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
BRD8	Q9H0E9	426	577	481	481	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
BRD8	Q9H0E9	426	577	509	509	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
BRD8	Q9H0E9	426	577	575	575	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733
BRD8	Q9H0E9	120	146	1	147	Alternative sequence	ID=VSP_012879;Note=In isoform 3. MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAT->MSFAMTL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8611617;Dbxref=PMID:8611617
BRD8	Q9H0E9	262	332	263	332	Alternative sequence	ID=VSP_023187;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
BRD8	Q9H0E9	262	332	263	301	Alternative sequence	ID=VSP_012881;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8611617;Dbxref=PMID:8611617
BRD8	Q9H0E9	844	859	845	859	Alternative sequence	ID=VSP_012882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8611617;Dbxref=PMID:8611617
BRD8	Q9H0E9	844	859	846	846	Alternative sequence	ID=VSP_023188;Note=In isoform 4. S->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
BRD8	Q9H0E9	844	859	847	975	Alternative sequence	ID=VSP_023189;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
BRD8	Q9H0E9	426	577	490	490	Natural variant	ID=VAR_030695;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs11750814
BRD8	Q9H0E9	262	332	306	306	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
BRD8	Q9H0E9	426	577	557	557	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
BRD8	Q9H0E9	426	577	557	557	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC102A	Q96A19	346	416	1	550	Chain	ID=PRO_0000274400;Note=Coiled-coil domain-containing protein 102A
CCDC102A	Q96A19	346	416	263	396	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CYP11B1	P15538	400	466	25	503	Chain	ID=PRO_0000003596;Note=Cytochrome P450 11B1%2C mitochondrial
CYP11B1	P15538	80	131	25	503	Chain	ID=PRO_0000003596;Note=Cytochrome P450 11B1%2C mitochondrial
CYP11B1	P15538	400	466	450	450	Metal binding	Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250
CYP11B1	P15538	400	466	401	466	Alternative sequence	ID=VSP_043308;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CYP11B1	P15538	80	131	83	83	Natural variant	ID=VAR_074495;Note=In AH4%3B highly decreases steroid 11-beta-hydroxylase activity. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=PMID:20089618
CYP11B1	P15538	80	131	88	88	Natural variant	ID=VAR_074496;Note=In AH4%3B slightly decreases steroid 11-beta-hydroxylase activity. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs193922539,PMID:20089618
CYP11B1	P15538	80	131	94	94	Natural variant	ID=VAR_065666;Note=In AH4%3B almost abolishes steroid 11-beta-hydroxylase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16046588,ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs104894070,PMID:16046588,PMID:20089618
CYP11B1	P15538	80	131	116	116	Natural variant	ID=VAR_074497;Note=In AH4%3B almost abolishes steroid 11-beta-hydroxylase activity. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs772003869,PMID:20089618
CYP11B1	P15538	80	131	116	116	Natural variant	ID=VAR_074498;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs772733691,PMID:20089618
CYP11B1	P15538	80	131	125	125	Natural variant	ID=VAR_074499;Note=In AH4%3B slightly decreases steroid 11-beta-hydroxylase activity. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs757389720,PMID:20089618
CYP11B1	P15538	80	131	129	129	Natural variant	ID=VAR_074500;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=PMID:20089618
CYP11B1	P15538	400	466	401	401	Natural variant	ID=VAR_074526;Note=In AH4%3B decreases steroid 11-beta-hydroxylase activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs201300785,PMID:20089618
CYP11B1	P15538	400	466	404	404	Natural variant	ID=VAR_048463;Note=R->H;Dbxref=dbSNP:rs4998896
CYP11B1	P15538	400	466	427	427	Natural variant	ID=VAR_074527;Note=In AH4. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs754432887,PMID:20089618
CYP11B1	P15538	400	466	438	438	Natural variant	ID=VAR_074528;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=PMID:20089618
CYP11B1	P15538	400	466	439	439	Natural variant	ID=VAR_014642;Note=Y->H;Dbxref=dbSNP:rs5294
CYP11B1	P15538	400	466	441	441	Natural variant	ID=VAR_074529;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs772169059,PMID:20089618
CYP11B1	P15538	400	466	444	444	Natural variant	ID=VAR_074530;Note=In AH4. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=dbSNP:rs779103938,PMID:20089618
CYP11B1	P15538	400	466	448	448	Natural variant	ID=VAR_074531;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=PMID:20089618
CYP11B1	P15538	400	466	448	448	Natural variant	ID=VAR_001265;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16046588,ECO:0000269|PubMed:20089618,ECO:0000269|PubMed:2022736,ECO:0000269|PubMed:24987415,ECO:0000269|PubMed:26476331;Dbxref=dbSNP:rs28934586,PMID:16046588,PMID:20089618,PMID:2022736,PMID:24987415,PMID:26476331
CYP11B1	P15538	400	466	453	453	Natural variant	ID=VAR_074532;Note=In AH4%3B abolishes steroid 11-beta-hydroxylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089618;Dbxref=PMID:20089618
CYP11B1	P15538	400	466	454	454	Natural variant	ID=VAR_065197;Note=In AH4. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20947076;Dbxref=PMID:20947076
CYP11B1	P15538	400	466	463	463	Natural variant	ID=VAR_074533;Note=In AH4%3B classic%3B abolishes steroid 11-beta-hydroxylase activity. L->LL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24536089;Dbxref=PMID:24536089
MTHFD1	P11586	42	62	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	62	80	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	473	498	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	558	605	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	605	628	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	819	855	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	855	906	1	935	Chain	ID=PRO_0000423280;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic
MTHFD1	P11586	42	62	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	62	80	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	473	498	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	558	605	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	605	628	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	819	855	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	855	906	2	935	Chain	ID=PRO_0000199321;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic%2C N-terminally processed
MTHFD1	P11586	42	62	2	305	Region	Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
MTHFD1	P11586	62	80	2	305	Region	Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
MTHFD1	P11586	42	62	52	56	Region	Note=Substrate binding
MTHFD1	P11586	473	498	306	935	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1	P11586	558	605	306	935	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1	P11586	605	628	306	935	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1	P11586	819	855	306	935	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1	P11586	855	906	306	935	Region	Note=Formyltetrahydrofolate synthetase
MTHFD1	P11586	473	498	490	490	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
MTHFD1	P11586	42	62	49	49	Natural variant	ID=VAR_074075;Note=In CIMAH. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25633902;Dbxref=PMID:25633902
MTHFD1	P11586	42	62	51	51	Natural variant	ID=VAR_080873;Note=In CIMAH. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27707659;Dbxref=PMID:27707659
MTHFD1	P11586	473	498	225	935	Natural variant	ID=VAR_080874;Note=In CIMAH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25633902;Dbxref=PMID:25633902
MTHFD1	P11586	558	605	225	935	Natural variant	ID=VAR_080874;Note=In CIMAH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25633902;Dbxref=PMID:25633902
MTHFD1	P11586	605	628	225	935	Natural variant	ID=VAR_080874;Note=In CIMAH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25633902;Dbxref=PMID:25633902
MTHFD1	P11586	819	855	225	935	Natural variant	ID=VAR_080874;Note=In CIMAH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25633902;Dbxref=PMID:25633902
MTHFD1	P11586	855	906	225	935	Natural variant	ID=VAR_080874;Note=In CIMAH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25633902;Dbxref=PMID:25633902
MTHFD1	P11586	42	62	49	49	Mutagenesis	Note=No effect on dehydrogenase and cyclohydrolase activity. Strong increase of Km for NADP. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	49	49	Mutagenesis	Note=Reduces dehydrogenase by 75%25 and cyclohydrolase activity by 99%25. No effect on Km for NADP and for 5%2C10-methenyltetrahydrofolate. S->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	52	52	Mutagenesis	Note=Reduces dehydrogenase activity by 99%25. Reduces cyclohydrolase activity by 70%25. No effect on Km for NADP and for 5%2C10-methenyltetrahydrofolate. Y->A%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	52	52	Mutagenesis	Note=Slightly reduces dehydrogenase and cyclohydrolase activity. Increase of Km for NADP and for 5%2C10-methenyltetrahydrofolate. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	56	56	Mutagenesis	Note=Decreases dehydrogenase activity over 90%25. Loss of cyclohydrolase activity. K->A%2CI%2CS%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	56	56	Mutagenesis	Note=Moderate decrease of dehydrogenase activity. Loss of cyclohydrolase activity. Strong increase of Km for NADP. Decrease of Km for 5%2C10-methenyltetrahydrofolate. K->E%2CM%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	56	56	Mutagenesis	Note=Reduces dehydrogenase and cyclohydrolase activity by 99%25. No effect on Km for NADP and for 5%2C10-methenyltetrahydrofolate. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10828945;Dbxref=PMID:10828945
MTHFD1	P11586	42	62	37	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A4I
MTHFD1	P11586	42	62	47	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A4I
MTHFD1	P11586	62	80	47	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A4I
MTHFD1	P11586	62	80	66	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A4I
MTHFD1	P11586	62	80	78	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A4I
SDHC	Q99643	26	59	1	29	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
SDHC	Q99643	26	59	30	169	Chain	ID=PRO_0000003634;Note=Succinate dehydrogenase cytochrome b560 subunit%2C mitochondrial
SDHC	Q99643	26	59	30	62	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250
SDHC	Q99643	26	59	7	59	Alternative sequence	ID=VSP_041381;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
SDHC	Q99643	26	59	27	60	Alternative sequence	ID=VSP_041382;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9851882,ECO:0000303|Ref.5;Dbxref=PMID:9851882
CACNA2D1	P54289	530	549	25	1103	Chain	ID=PRO_0000304633;Note=Voltage-dependent calcium channel subunit alpha-2/delta-1
CACNA2D1	P54289	243	259	25	1103	Chain	ID=PRO_0000304633;Note=Voltage-dependent calcium channel subunit alpha-2/delta-1
CACNA2D1	P54289	118	132	25	1103	Chain	ID=PRO_0000304633;Note=Voltage-dependent calcium channel subunit alpha-2/delta-1
CACNA2D1	P54289	530	549	25	956	Chain	ID=PRO_0000005001;Note=Voltage-dependent calcium channel subunit alpha-2-1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D1	P54289	243	259	25	956	Chain	ID=PRO_0000005001;Note=Voltage-dependent calcium channel subunit alpha-2-1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D1	P54289	118	132	25	956	Chain	ID=PRO_0000005001;Note=Voltage-dependent calcium channel subunit alpha-2-1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D1	P54289	530	549	25	1073	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D1	P54289	243	259	25	1073	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D1	P54289	118	132	25	1073	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA2D1	P54289	243	259	253	430	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CACNA2D1	P54289	530	549	446	556	Domain	Note=Cache
CACNA2D1	P54289	243	259	259	263	Motif	Note=MIDAS-like motif
CACNA2D1	P54289	243	259	259	259	Metal binding	Note=Divalent metal cation;Ontology_term=ECO:0000250;evidence=ECO:0000250
CACNA2D1	P54289	118	132	119	119	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54290
CACNA2D1	P54289	530	549	404	1059	Disulfide bond	Note=Interchain (between alpha-2-1 and delta-1 chains)
CACNA2D1	P54289	530	549	531	554	Alternative sequence	ID=VSP_038349;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8107964;Dbxref=PMID:8107964
CACNA2D1	P54289	530	549	531	549	Alternative sequence	ID=VSP_038348;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1309651,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8107964;Dbxref=PMID:1309651,PMID:15489334,PMID:8107964
C1orf50	Q9BV19	65	94	1	199	Chain	ID=PRO_0000251189;Note=Uncharacterized protein C1orf50
C1orf50	Q9BV19	65	94	71	101	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH15	P55291	264	326	61	814	Chain	ID=PRO_0000003806;Note=Cadherin-15
CDH15	P55291	264	326	61	606	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH15	P55291	264	326	261	375	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
DPY19L1	Q2PZI1	582	623	1	675	Chain	ID=PRO_0000311877;Note=Probable C-mannosyltransferase DPY19L1
DPY19L1	Q2PZI1	450	490	1	675	Chain	ID=PRO_0000311877;Note=Probable C-mannosyltransferase DPY19L1
DPY19L1	Q2PZI1	291	320	1	675	Chain	ID=PRO_0000311877;Note=Probable C-mannosyltransferase DPY19L1
DPY19L1	Q2PZI1	265	291	1	675	Chain	ID=PRO_0000311877;Note=Probable C-mannosyltransferase DPY19L1
DPY19L1	Q2PZI1	265	291	260	279	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L1	Q2PZI1	291	320	286	303	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L1	Q2PZI1	265	291	286	303	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L1	Q2PZI1	291	320	309	325	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L1	Q2PZI1	450	490	449	469	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DPY19L1	Q2PZI1	582	623	1	590	Alternative sequence	ID=VSP_029628;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DPY19L1	Q2PZI1	450	490	1	590	Alternative sequence	ID=VSP_029628;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DPY19L1	Q2PZI1	291	320	1	590	Alternative sequence	ID=VSP_029628;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DPY19L1	Q2PZI1	265	291	1	590	Alternative sequence	ID=VSP_029628;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDH6	P55285	174	214	54	790	Chain	ID=PRO_0000003762;Note=Cadherin-6
CDH6	P55285	543	627	54	790	Chain	ID=PRO_0000003762;Note=Cadherin-6
CDH6	P55285	174	214	54	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH6	P55285	543	627	54	615	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH6	P55285	543	627	616	636	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH6	P55285	174	214	160	268	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH6	P55285	543	627	487	608	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH6	P55285	543	627	543	551	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VEB
CDH6	P55285	543	627	558	560	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VEB
CDH6	P55285	543	627	562	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VEB
CDH6	P55285	543	627	573	576	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VEB
CDH6	P55285	543	627	579	589	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VEB
CA13	Q8N1Q1	12	78	1	262	Chain	ID=PRO_0000077440;Note=Carbonic anhydrase 13
CA13	Q8N1Q1	12	78	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA13	Q8N1Q1	12	78	65	65	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00918
CA13	Q8N1Q1	12	78	68	68	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00918
CA13	Q8N1Q1	12	78	68	68	Natural variant	ID=VAR_059207;Note=N->S;Dbxref=dbSNP:rs4740046
CA13	Q8N1Q1	12	78	10	12	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	14	20	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	22	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	36	38	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	56	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	64	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
CA13	Q8N1Q1	12	78	74	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KNN
BIRC7	Q96CA5	192	216	1	298	Chain	ID=PRO_0000122362;Note=Baculoviral IAP repeat-containing protein 7
BIRC7	Q96CA5	192	216	53	298	Chain	ID=PRO_0000416092;Note=Baculoviral IAP repeat-containing protein 7 30kDa subunit
BIRC7	Q96CA5	192	216	216	233	Alternative sequence	ID=VSP_002459;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11024045,ECO:0000303|PubMed:12975309;Dbxref=PMID:11024045,PMID:12975309
BLVRB	P30043	111	154	2	206	Chain	ID=PRO_0000064948;Note=Flavin reductase (NADPH)
BLVRB	P30043	81	111	2	206	Chain	ID=PRO_0000064948;Note=Flavin reductase (NADPH)
BLVRB	P30043	26	81	2	206	Chain	ID=PRO_0000064948;Note=Flavin reductase (NADPH)
BLVRB	P30043	26	81	54	55	Nucleotide binding	Note=NADP
BLVRB	P30043	26	81	75	78	Nucleotide binding	Note=NADP
BLVRB	P30043	26	81	35	35	Binding site	Note=NADP
BLVRB	P30043	111	154	132	132	Binding site	Note=NADP
BLVRB	P30043	111	154	153	153	Binding site	Note=Substrate
BLVRB	P30043	111	154	154	154	Binding site	Note=NADP%3B via amide nitrogen
BLVRB	P30043	26	81	42	42	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BLVRB	P30043	81	111	82	82	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BLVRB	P30043	26	81	46	46	Natural variant	ID=VAR_019168;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs11547746
BLVRB	P30043	111	154	153	153	Mutagenesis	Note=Reduced affinity for biliverdin. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18241201;Dbxref=PMID:18241201
BLVRB	P30043	26	81	29	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	26	81	37	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	26	81	42	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	26	81	48	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	26	81	58	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	26	81	69	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	81	111	86	101	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	81	111	105	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	111	154	112	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	111	154	118	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HE2
BLVRB	P30043	111	154	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	111	154	126	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	111	154	144	149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BLVRB	P30043	111	154	152	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HDO
BMPR2	Q13873	82	139	27	1038	Chain	ID=PRO_0000024415;Note=Bone morphogenetic protein receptor type-2
BMPR2	Q13873	139	176	27	1038	Chain	ID=PRO_0000024415;Note=Bone morphogenetic protein receptor type-2
BMPR2	Q13873	207	284	27	1038	Chain	ID=PRO_0000024415;Note=Bone morphogenetic protein receptor type-2
BMPR2	Q13873	82	139	27	150	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	139	176	27	150	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	139	176	151	171	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	139	176	172	1038	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	207	284	172	1038	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	207	284	203	504	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
BMPR2	Q13873	207	284	209	217	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.13
BMPR2	Q13873	207	284	280	282	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.13
BMPR2	Q13873	207	284	230	230	Binding site	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.13
BMPR2	Q13873	82	139	110	110	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	82	139	126	126	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMPR2	Q13873	82	139	60	84	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2HLQ,ECO:0000269|PubMed:17094948;Dbxref=PMID:17094948
BMPR2	Q13873	82	139	94	117	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2HLQ,ECO:0000269|PubMed:17094948;Dbxref=PMID:17094948
BMPR2	Q13873	82	139	99	116	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2HLQ,ECO:0000269|PubMed:17094948;Dbxref=PMID:17094948
BMPR2	Q13873	82	139	118	123	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2HLQ,ECO:0000269|PubMed:17094948;Dbxref=PMID:17094948
BMPR2	Q13873	82	139	82	82	Natural variant	ID=VAR_033109;Note=In PPH1. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12358323;Dbxref=dbSNP:rs1085307185,PMID:12358323
BMPR2	Q13873	82	139	84	84	Natural variant	ID=VAR_079590;Note=In PPH1%3B alters alternative splicing of BMPR2. C->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24936649,ECO:0000269|PubMed:28507310;Dbxref=dbSNP:rs1085307197,PMID:24936649,PMID:28507310
BMPR2	Q13873	82	139	87	87	Natural variant	ID=VAR_079591;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. H->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24936649,ECO:0000269|PubMed:28507310;Dbxref=PMID:24936649,PMID:28507310
BMPR2	Q13873	82	139	92	92	Natural variant	ID=VAR_079592;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. Q->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24936649,ECO:0000269|PubMed:28507310;Dbxref=PMID:24936649,PMID:28507310
BMPR2	Q13873	82	139	109	109	Natural variant	ID=VAR_079593;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28507310;Dbxref=PMID:28507310
BMPR2	Q13873	82	139	117	117	Natural variant	ID=VAR_013671;Note=In PPH1. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11015450;Dbxref=PMID:11015450
BMPR2	Q13873	82	139	118	118	Natural variant	ID=VAR_013672;Note=In PPH1. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10973254;Dbxref=dbSNP:rs137852743,PMID:10973254
BMPR2	Q13873	82	139	123	123	Natural variant	ID=VAR_013673;Note=In PPH1. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11115378;Dbxref=dbSNP:rs137852750,PMID:11115378
BMPR2	Q13873	82	139	123	123	Natural variant	ID=VAR_013674;Note=In PPH1. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11115378;Dbxref=dbSNP:rs137852750,PMID:11115378
BMPR2	Q13873	82	139	138	138	Natural variant	ID=VAR_079594;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28507310;Dbxref=PMID:28507310
BMPR2	Q13873	139	176	162	162	Natural variant	ID=VAR_079595;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. A->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24936649,ECO:0000269|PubMed:28507310;Dbxref=PMID:24936649,PMID:28507310
BMPR2	Q13873	207	284	218	1038	Natural variant	ID=VAR_079596;Note=In PPH1%3B changed localization to the plasma membrane. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28507310;Dbxref=PMID:28507310
BMPR2	Q13873	207	284	224	224	Natural variant	ID=VAR_013675;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11115378;Dbxref=dbSNP:rs754343081,PMID:11115378
BMPR2	Q13873	207	284	248	248	Natural variant	ID=VAR_079597;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28507310;Dbxref=PMID:28507310
BMPR2	Q13873	207	284	264	264	Natural variant	ID=VAR_079598;Note=In PPH1%3B unknown pathological significance%3B unchanged subcellular localization. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24936649,ECO:0000269|PubMed:28507310;Dbxref=PMID:24936649,PMID:28507310
BMPR2	Q13873	82	139	76	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLQ
BMPR2	Q13873	82	139	90	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLQ
BMPR2	Q13873	82	139	105	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLQ
BMPR2	Q13873	82	139	113	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLQ
BMPR2	Q13873	82	139	123	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HLQ
BMPR2	Q13873	207	284	202	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BMPR2	Q13873	207	284	213	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BMPR2	Q13873	207	284	225	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BMPR2	Q13873	207	284	234	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BMPR2	Q13873	207	284	237	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BMPR2	Q13873	207	284	260	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BMPR2	Q13873	207	284	273	279	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G2F
BPIFB2	Q8N4F0	285	303	21	458	Chain	ID=PRO_0000017164;Note=BPI fold-containing family B member 2
BPIFB2	Q8N4F0	303	360	21	458	Chain	ID=PRO_0000017164;Note=BPI fold-containing family B member 2
BPIFB2	Q8N4F0	285	303	293	293	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16740002;Dbxref=PMID:16740002
BPIFB2	Q8N4F0	303	360	332	332	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16740002;Dbxref=PMID:16740002
BPTF	Q12830	621	684	1	3046	Chain	ID=PRO_0000087176;Note=Nucleosome-remodeling factor subunit BPTF
BPTF	Q12830	684	747	1	3046	Chain	ID=PRO_0000087176;Note=Nucleosome-remodeling factor subunit BPTF
BPTF	Q12830	1063	1123	1	3046	Chain	ID=PRO_0000087176;Note=Nucleosome-remodeling factor subunit BPTF
BPTF	Q12830	621	684	640	749	Region	Note=Interaction with KEAP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15379550;Dbxref=PMID:15379550
BPTF	Q12830	684	747	640	749	Region	Note=Interaction with KEAP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15379550;Dbxref=PMID:15379550
BPTF	Q12830	1063	1123	1064	1064	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:21406692
BPTF	Q12830	1063	1123	1088	1088	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
BPTF	Q12830	621	684	622	747	Alternative sequence	ID=VSP_020402;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662542;Dbxref=PMID:10662542
BPTF	Q12830	684	747	622	747	Alternative sequence	ID=VSP_020402;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662542;Dbxref=PMID:10662542
BROX	Q5VW32	102	133	1	408	Chain	ID=PRO_0000304612;Note=BRO1 domain-containing protein BROX
BROX	Q5VW32	102	133	90	408	Domain	Note=BRO1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00526
BROX	Q5VW32	102	133	103	134	Alternative sequence	ID=VSP_055551;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
BROX	Q5VW32	102	133	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R9M
BROX	Q5VW32	102	133	107	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R9M
BRD7	Q9NPI1	481	500	1	651	Chain	ID=PRO_0000227664;Note=Bromodomain-containing protein 7
BRD7	Q9NPI1	362	398	1	651	Chain	ID=PRO_0000227664;Note=Bromodomain-containing protein 7
BRD7	Q9NPI1	362	398	380	380	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BRD7	Q9NPI1	481	500	482	482	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88665
BRD7	Q9NPI1	362	398	389	389	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRD7	Q9NPI1	481	500	500	500	Alternative sequence	ID=VSP_017564;Note=In isoform 2. E->EQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11025449,ECO:0000303|PubMed:15489334;Dbxref=PMID:11025449,PMID:15489334
BRD7	Q9NPI1	481	500	485	485	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTAF1	O14981	84	133	1	1849	Chain	ID=PRO_0000074311;Note=TATA-binding protein-associated factor 172
BTAF1	O14981	277	300	1	1849	Chain	ID=PRO_0000074311;Note=TATA-binding protein-associated factor 172
BTAF1	O14981	1220	1271	1	1849	Chain	ID=PRO_0000074311;Note=TATA-binding protein-associated factor 172
BTAF1	O14981	1368	1393	1	1849	Chain	ID=PRO_0000074311;Note=TATA-binding protein-associated factor 172
BTAF1	O14981	1528	1570	1	1849	Chain	ID=PRO_0000074311;Note=TATA-binding protein-associated factor 172
BTAF1	O14981	1368	1393	1278	1453	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
BTAF1	O14981	84	133	91	91	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BTAF1	O14981	84	133	95	95	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BTAF1	O14981	84	133	1	1172	Alternative sequence	ID=VSP_056510;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTAF1	O14981	277	300	1	1172	Alternative sequence	ID=VSP_056510;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTBD1	Q9H0C5	381	430	1	482	Chain	ID=PRO_0000186208;Note=BTB/POZ domain-containing protein 1
BTBD1	Q9H0C5	221	287	1	482	Chain	ID=PRO_0000186208;Note=BTB/POZ domain-containing protein 1
BTBD1	Q9H0C5	221	287	184	284	Domain	Note=BACK;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTBD1	Q9H0C5	381	430	353	386	Alternative sequence	ID=VSP_047146;Note=In isoform 2. FTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYE->SLNMRKSKPWDRMIPALVVMGQLTHSGSCSRNP;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTBD1	Q9H0C5	381	430	387	482	Alternative sequence	ID=VSP_047147;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTBD1	Q9H0C5	381	430	406	406	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTBD1	Q9H0C5	381	430	422	422	Sequence conflict	Note=C->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTBD1	Q9H0C5	381	430	429	429	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTN2A2	Q8WVV5	31	147	1	32	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	1	32	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	33	523	Chain	ID=PRO_0000014530;Note=Butyrophilin subfamily 2 member A2
BTN2A2	Q8WVV5	147	241	33	523	Chain	ID=PRO_0000014530;Note=Butyrophilin subfamily 2 member A2
BTN2A2	Q8WVV5	31	147	33	523	Chain	ID=PRO_0000014530;Note=Butyrophilin subfamily 2 member A2
BTN2A2	Q8WVV5	147	241	33	523	Chain	ID=PRO_0000014530;Note=Butyrophilin subfamily 2 member A2
BTN2A2	Q8WVV5	31	147	33	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	147	241	33	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	33	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	147	241	33	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	34	145	Domain	Note=Ig-like V-type
BTN2A2	Q8WVV5	31	147	34	145	Domain	Note=Ig-like V-type
BTN2A2	Q8WVV5	147	241	153	234	Domain	Note=Ig-like C2-type
BTN2A2	Q8WVV5	147	241	153	234	Domain	Note=Ig-like C2-type
BTN2A2	Q8WVV5	31	147	50	50	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	50	50	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	118	118	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	147	241	220	220	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	147	241	220	220	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	147	241	226	226	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	147	241	226	226	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN2A2	Q8WVV5	31	147	55	129	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BTN2A2	Q8WVV5	31	147	55	129	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BTN2A2	Q8WVV5	31	147	32	241	Alternative sequence	ID=VSP_044861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	147	241	32	241	Alternative sequence	ID=VSP_044861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	31	147	32	241	Alternative sequence	ID=VSP_044861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	147	241	32	241	Alternative sequence	ID=VSP_044861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	31	147	32	147	Alternative sequence	ID=VSP_043561;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	147	241	32	147	Alternative sequence	ID=VSP_043561;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	31	147	32	147	Alternative sequence	ID=VSP_043561;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	147	241	32	147	Alternative sequence	ID=VSP_043561;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	147	241	148	241	Alternative sequence	ID=VSP_043562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTN2A2	Q8WVV5	147	241	148	241	Alternative sequence	ID=VSP_043562;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BTF3	P20290	44	67	1	206	Chain	ID=PRO_0000213548;Note=Transcription factor BTF3
BTF3	P20290	67	105	1	206	Chain	ID=PRO_0000213548;Note=Transcription factor BTF3
BTF3	P20290	172	191	1	206	Chain	ID=PRO_0000213548;Note=Transcription factor BTF3
BTF3	P20290	67	105	82	147	Domain	Note=NAC-A/B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00507
BTF3	P20290	172	191	185	188	Compositional bias	Note=Poly-Asp
BTF3	P20290	44	67	46	46	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
BTF3	P20290	44	67	54	54	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
BTF3	P20290	172	191	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BTF3	P20290	44	67	1	44	Alternative sequence	ID=VSP_013587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2320128,ECO:0000303|Ref.3,ECO:0000303|Ref.4,ECO:0000303|Ref.5;Dbxref=PMID:14702039,PMID:15489334,PMID:2320128
BTF3	P20290	67	105	68	105	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTF3	P20290	67	105	105	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MCB
BTLA	Q7Z6A9	134	182	31	289	Chain	ID=PRO_0000014523;Note=B- and T-lymphocyte attenuator
BTLA	Q7Z6A9	134	182	31	157	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTLA	Q7Z6A9	134	182	158	178	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTLA	Q7Z6A9	134	182	179	289	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTLA	Q7Z6A9	134	182	135	182	Alternative sequence	ID=VSP_040305;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2,ECO:0000303|Ref.3;Dbxref=PMID:15489334
BTLA	Q7Z6A9	134	182	157	157	Natural variant	ID=VAR_027607;Note=R->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12796776,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2931761,PMID:12796776,PMID:14702039,PMID:15489334
BTLA	Q7Z6A9	134	182	138	138	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTLA	Q7Z6A9	134	182	148	148	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTLA	Q7Z6A9	134	182	171	171	Sequence conflict	Note=C->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTLA	Q7Z6A9	134	182	129	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AW2
BTNL9	Q6UXG8	36	151	35	535	Chain	ID=PRO_0000014542;Note=Butyrophilin-like protein 9
BTNL9	Q6UXG8	284	295	35	535	Chain	ID=PRO_0000014542;Note=Butyrophilin-like protein 9
BTNL9	Q6UXG8	36	151	35	256	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTNL9	Q6UXG8	284	295	278	535	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTNL9	Q6UXG8	36	151	54	135	Domain	Note=Ig-like V-type
BTNL9	Q6UXG8	284	295	276	315	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BTNL9	Q6UXG8	36	151	102	102	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTNL9	Q6UXG8	36	151	139	139	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTNL9	Q6UXG8	36	151	59	133	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BUB1	O43683	734	782	1	1085	Chain	ID=PRO_0000085671;Note=Mitotic checkpoint serine/threonine-protein kinase BUB1
BUB1	O43683	9	28	1	1085	Chain	ID=PRO_0000085671;Note=Mitotic checkpoint serine/threonine-protein kinase BUB1
BUB1	O43683	9	28	11	182	Domain	Note=BUB1 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00822
BUB1	O43683	9	28	1	146	Region	Note=Necessary for kinetochore localization
BUB1	O43683	9	28	10	29	Alternative sequence	ID=VSP_054760;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BUB1	O43683	9	28	20	20	Natural variant	ID=VAR_040400;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35890336,PMID:17344846
BUB1	O43683	9	28	3	14	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A1G
BUB1	O43683	9	28	23	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A1G
BUB1	O43683	734	782	737	739	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R8Q
BUB1	O43683	734	782	744	752	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPM
BUB1	O43683	734	782	758	760	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPM
BUB1	O43683	734	782	764	766	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPM
BUB1	O43683	734	782	778	782	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPM
BZW2	Q9Y6E2	19	78	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	217	274	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	19	78	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	217	274	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	217	274	248	415	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
BZW2	Q9Y6E2	217	274	248	415	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
BZW2	Q9Y6E2	217	274	202	419	Alternative sequence	ID=VSP_055569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BZW2	Q9Y6E2	217	274	202	419	Alternative sequence	ID=VSP_055569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BZW2	Q9Y6E2	19	78	44	44	Natural variant	ID=VAR_033642;Note=D->A;Dbxref=dbSNP:rs35233079
BZW2	Q9Y6E2	19	78	44	44	Natural variant	ID=VAR_033642;Note=D->A;Dbxref=dbSNP:rs35233079
CCDC102B	Q68D86	351	421	1	513	Chain	ID=PRO_0000079308;Note=Coiled-coil domain-containing protein 102B
CCDC102B	Q68D86	421	478	1	513	Chain	ID=PRO_0000079308;Note=Coiled-coil domain-containing protein 102B
CCDC102B	Q68D86	351	421	363	513	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC102B	Q68D86	421	478	363	513	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC102B	Q68D86	351	421	370	370	Natural variant	ID=VAR_047333;Note=E->G;Dbxref=dbSNP:rs34102373
CCDC102B	Q68D86	421	478	425	425	Natural variant	ID=VAR_047334;Note=N->K;Dbxref=dbSNP:rs17080065
CCDC102B	Q68D86	421	478	429	429	Natural variant	ID=VAR_022894;Note=A->P;Dbxref=dbSNP:rs9963788
CCDC102B	Q68D86	351	421	382	382	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC102B	Q68D86	421	478	469	469	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD164L2	Q6UWJ8	109	124	30	174	Chain	ID=PRO_0000045779;Note=CD164 sialomucin-like 2 protein
CD164L2	Q6UWJ8	109	124	30	141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CWF19L2	Q2TBE0	734	786	1	894	Chain	ID=PRO_0000315648;Note=CWF19-like protein 2
CWF19L2	Q2TBE0	578	624	1	894	Chain	ID=PRO_0000315648;Note=CWF19-like protein 2
CWF19L2	Q2TBE0	509	539	1	894	Chain	ID=PRO_0000315648;Note=CWF19-like protein 2
CWF19L2	Q2TBE0	509	539	502	530	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CWF19L2	Q2TBE0	578	624	604	604	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
CWF19L2	Q2TBE0	734	786	673	894	Alternative sequence	ID=VSP_030591;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CWF19L2	Q2TBE0	734	786	735	742	Alternative sequence	ID=VSP_030592;Note=In isoform 2. MFRKSLVK->IKSRTVIQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CWF19L2	Q2TBE0	734	786	743	894	Alternative sequence	ID=VSP_030593;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CWF19L2	Q2TBE0	509	539	537	537	Natural variant	ID=VAR_038271;Note=G->R;Dbxref=dbSNP:rs17106909
CWF19L2	Q2TBE0	578	624	584	584	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
C4BPB	P20851	19	77	18	252	Chain	ID=PRO_0000005892;Note=C4b-binding protein beta chain
C4BPB	P20851	19	77	18	252	Chain	ID=PRO_0000005892;Note=C4b-binding protein beta chain
C4BPB	P20851	19	77	18	252	Chain	ID=PRO_0000005892;Note=C4b-binding protein beta chain
C4BPB	P20851	19	77	21	78	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	21	78	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	21	78	Domain	Note=Sushi 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952
C4BPB	P20851	19	77	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952
C4BPB	P20851	19	77	64	64	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952
C4BPB	P20851	19	77	71	71	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14760718;Dbxref=PMID:14760718
C4BPB	P20851	19	77	71	71	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14760718;Dbxref=PMID:14760718
C4BPB	P20851	19	77	71	71	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14760718;Dbxref=PMID:14760718
C4BPB	P20851	19	77	23	63	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	23	63	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	23	63	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	49	76	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	49	76	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	49	76	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
C4BPB	P20851	19	77	20	20	Alternative sequence	ID=VSP_022594;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C4BPB	P20851	19	77	20	20	Alternative sequence	ID=VSP_022594;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C4BPB	P20851	19	77	20	20	Alternative sequence	ID=VSP_022594;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C1QBP	Q07021	159	192	74	282	Chain	ID=PRO_0000018590;Note=Complement component 1 Q subcomponent-binding protein%2C mitochondrial
C1QBP	Q07021	159	192	168	213	Region	Note=Interaction with MAVS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19164550;Dbxref=PMID:19164550
C1QBP	Q07021	159	192	188	188	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:19690332;Dbxref=PMID:17693683,PMID:19690332
C1QBP	Q07021	159	192	186	186	Natural variant	ID=VAR_080391;Note=In COXPD33%3B unknown pathological significance. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28942965;Dbxref=dbSNP:rs748497469,PMID:28942965
C1QBP	Q07021	159	192	188	188	Natural variant	ID=VAR_080392;Note=In COXPD33%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28942965;Dbxref=PMID:28942965
C1QBP	Q07021	159	192	168	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P32
C1QBP	Q07021	159	192	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P32
C1QBP	Q07021	159	192	180	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P32
CDC42SE2	Q9NRR3	18	52	1	84	Chain	ID=PRO_0000334639;Note=CDC42 small effector protein 2
CDC42SE2	Q9NRR3	18	52	1	84	Chain	ID=PRO_0000334639;Note=CDC42 small effector protein 2
CDC42SE2	Q9NRR3	18	52	1	84	Chain	ID=PRO_0000334639;Note=CDC42 small effector protein 2
CDC42SE2	Q9NRR3	18	52	29	42	Domain	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057
CDC42SE2	Q9NRR3	18	52	29	42	Domain	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057
CDC42SE2	Q9NRR3	18	52	29	42	Domain	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057
CDC42SE2	Q9NRR3	18	52	20	23	Compositional bias	Note=Poly-Arg
CDC42SE2	Q9NRR3	18	52	20	23	Compositional bias	Note=Poly-Arg
CDC42SE2	Q9NRR3	18	52	20	23	Compositional bias	Note=Poly-Arg
CDC42SE2	Q9NRR3	18	52	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGH7
CDC42SE2	Q9NRR3	18	52	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGH7
CDC42SE2	Q9NRR3	18	52	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGH7
CDC42SE2	Q9NRR3	18	52	52	52	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGH7
CDC42SE2	Q9NRR3	18	52	52	52	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGH7
CDC42SE2	Q9NRR3	18	52	52	52	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGH7
CDH18	Q13634	543	627	54	790	Chain	ID=PRO_0000003816;Note=Cadherin-18
CDH18	Q13634	543	627	54	790	Chain	ID=PRO_0000003816;Note=Cadherin-18
CDH18	Q13634	543	627	54	790	Chain	ID=PRO_0000003816;Note=Cadherin-18
CDH18	Q13634	543	627	54	608	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH18	Q13634	543	627	54	608	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH18	Q13634	543	627	54	608	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH18	Q13634	543	627	609	636	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH18	Q13634	543	627	609	636	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH18	Q13634	543	627	609	636	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH18	Q13634	543	627	487	608	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH18	Q13634	543	627	487	608	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH18	Q13634	543	627	487	608	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH18	Q13634	543	627	544	790	Alternative sequence	ID=VSP_042308;Note=In isoform 2. DNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT->AAAPSPSGFVHAREMGVCGPAMQKPSCPRLV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDH18	Q13634	543	627	544	790	Alternative sequence	ID=VSP_042308;Note=In isoform 2. DNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT->AAAPSPSGFVHAREMGVCGPAMQKPSCPRLV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDH18	Q13634	543	627	544	790	Alternative sequence	ID=VSP_042308;Note=In isoform 2. DNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT->AAAPSPSGFVHAREMGVCGPAMQKPSCPRLV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES1	Q8TDN4	282	305	1	633	Chain	ID=PRO_0000080510;Note=CDK5 and ABL1 enzyme substrate 1
CABLES1	Q8TDN4	306	336	1	633	Chain	ID=PRO_0000080510;Note=CDK5 and ABL1 enzyme substrate 1
CABLES1	Q8TDN4	337	362	1	633	Chain	ID=PRO_0000080510;Note=CDK5 and ABL1 enzyme substrate 1
CABLES1	Q8TDN4	282	305	179	492	Region	Note=Interaction with CDK3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CABLES1	Q8TDN4	306	336	179	492	Region	Note=Interaction with CDK3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CABLES1	Q8TDN4	337	362	179	492	Region	Note=Interaction with CDK3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CABLES1	Q8TDN4	282	305	287	287	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
CABLES1	Q8TDN4	306	336	313	313	Modified residue	Note=Phosphoserine%3B by CDK2 and CDK3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9ESJ1
CABLES1	Q8TDN4	282	305	1	497	Alternative sequence	ID=VSP_012695;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES1	Q8TDN4	306	336	1	497	Alternative sequence	ID=VSP_012695;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES1	Q8TDN4	337	362	1	497	Alternative sequence	ID=VSP_012695;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES1	Q8TDN4	282	305	1	327	Alternative sequence	ID=VSP_045014;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES1	Q8TDN4	306	336	1	327	Alternative sequence	ID=VSP_045014;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES1	Q8TDN4	282	305	266	282	Alternative sequence	ID=VSP_012697;Note=In isoform 2. PGQGGSTSAFEQLQRSR->MLSKRGCHARIYADFPI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CALCOCO1	Q9P1Z2	420	462	1	691	Chain	ID=PRO_0000308899;Note=Calcium-binding and coiled-coil domain-containing protein 1
CALCOCO1	Q9P1Z2	335	420	1	691	Chain	ID=PRO_0000308899;Note=Calcium-binding and coiled-coil domain-containing protein 1
CALCOCO1	Q9P1Z2	283	335	1	691	Chain	ID=PRO_0000308899;Note=Calcium-binding and coiled-coil domain-containing protein 1
CALCOCO1	Q9P1Z2	335	420	232	339	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CALCOCO1	Q9P1Z2	283	335	232	339	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CALCOCO1	Q9P1Z2	420	462	417	514	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CALCOCO1	Q9P1Z2	335	420	417	514	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CALCOCO1	Q9P1Z2	335	420	367	372	Compositional bias	Note=Poly-Ala
CALCOCO1	Q9P1Z2	335	420	287	338	Alternative sequence	ID=VSP_041472;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CALCOCO1	Q9P1Z2	283	335	287	338	Alternative sequence	ID=VSP_041472;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CALCOCO1	Q9P1Z2	335	420	393	393	Natural variant	ID=VAR_036881;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3741659,PMID:14702039
CALCOCO1	Q9P1Z2	335	420	381	381	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDH8	P55286	222	278	62	799	Chain	ID=PRO_0000003774;Note=Cadherin-8
CDH8	P55286	222	278	62	621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH8	P55286	222	278	168	276	Domain	Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH8	P55286	222	278	277	391	Domain	Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CACNA1F	O60840	1835	1901	1	1977	Chain	ID=PRO_0000053950;Note=Voltage-dependent L-type calcium channel subunit alpha-1F
CACNA1F	O60840	987	1023	1	1977	Chain	ID=PRO_0000053950;Note=Voltage-dependent L-type calcium channel subunit alpha-1F
CACNA1F	O60840	902	922	1	1977	Chain	ID=PRO_0000053950;Note=Voltage-dependent L-type calcium channel subunit alpha-1F
CACNA1F	O60840	902	922	891	906	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1F	O60840	902	922	907	926	Transmembrane	Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1F	O60840	987	1023	984	1002	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1F	O60840	987	1023	1003	1022	Transmembrane	Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1F	O60840	987	1023	1023	1112	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1F	O60840	1835	1901	1442	1977	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1F	O60840	987	1023	858	1140	Repeat	Note=III
CACNA1F	O60840	902	922	858	1140	Repeat	Note=III
CACNA1F	O60840	1835	1901	1836	1901	Alternative sequence	ID=VSP_058924;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27226626;Dbxref=PMID:27226626
CACNA1F	O60840	987	1023	1018	1018	Natural variant	ID=VAR_030818;Note=In CSNB2A. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111638;Dbxref=dbSNP:rs1249437161,PMID:12111638
CACNA1F	O60840	1835	1901	1860	1860	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CADM3	Q8N126	127	173	25	398	Chain	ID=PRO_0000046067;Note=Cell adhesion molecule 3
CADM3	Q8N126	173	230	25	398	Chain	ID=PRO_0000046067;Note=Cell adhesion molecule 3
CADM3	Q8N126	127	173	25	330	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM3	Q8N126	173	230	25	330	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CADM3	Q8N126	127	173	130	228	Domain	Note=Ig-like C2-type 1
CADM3	Q8N126	173	230	130	228	Domain	Note=Ig-like C2-type 1
CADM3	Q8N126	127	173	152	209	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CADM3	Q8N126	173	230	152	209	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CADM3	Q8N126	173	230	185	231	Alternative sequence	ID=VSP_022008;Note=In isoform 3. GKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLY->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
CADM3	Q8N126	127	173	162	162	Natural variant	ID=VAR_059383;Note=R->W;Dbxref=dbSNP:rs3026987
CADM3	Q8N126	127	173	118	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z9M
CHAF1A	Q13111	320	339	1	956	Chain	ID=PRO_0000089276;Note=Chromatin assembly factor 1 subunit A
CHAF1A	Q13111	436	459	1	956	Chain	ID=PRO_0000089276;Note=Chromatin assembly factor 1 subunit A
CHAF1A	Q13111	320	339	323	453	Compositional bias	Note=Arg/Glu/Lys-rich
CHAF1A	Q13111	436	459	323	453	Compositional bias	Note=Arg/Glu/Lys-rich
CALB1	P05937	52	77	2	261	Chain	ID=PRO_0000073472;Note=Calbindin
CALB1	P05937	52	77	53	88	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CALB1	P05937	52	77	1	57	Alternative sequence	ID=VSP_055508;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAAF1	Q8NEP3	548	566	1	725	Chain	ID=PRO_0000232889;Note=Dynein assembly factor 1%2C axonemal
DNAAF1	Q8NEP3	548	566	559	559	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D2H9
DNAAF1	Q8NEP3	548	566	562	562	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D2H9
DNAAF1	Q8NEP3	548	566	409	725	Alternative sequence	ID=VSP_036356;Note=In isoform 3. GPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQELSDEDPSGQLLMPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAATPPETCVGVAQPSQALPTWDLTAFPAPKAS->DPATVTACEG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAB2	P98082	229	447	2	770	Chain	ID=PRO_0000079770;Note=Disabled homolog 2
DAB2	P98082	208	229	2	770	Chain	ID=PRO_0000079770;Note=Disabled homolog 2
DAB2	P98082	229	447	230	447	Region	Note=Required for localization to clathrin-coated pits;Ontology_term=ECO:0000250;evidence=ECO:0000250
DAB2	P98082	229	447	293	295	Motif	Note=DPF 1
DAB2	P98082	229	447	298	300	Motif	Note=DPF 2
DAB2	P98082	229	447	326	326	Modified residue	Note=Phosphoserine%3B in mitosis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88797
DAB2	P98082	229	447	328	328	Modified residue	Note=Phosphoserine%3B in mitosis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88797
DAB2	P98082	229	447	401	401	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163,PMID:24275569
DAB2	P98082	229	447	209	229	Alternative sequence	ID=VSP_038401;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10340382,ECO:0000303|PubMed:11161789;Dbxref=PMID:10340382,PMID:11161789
DAB2	P98082	208	229	209	229	Alternative sequence	ID=VSP_038401;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10340382,ECO:0000303|PubMed:11161789;Dbxref=PMID:10340382,PMID:11161789
DAB2	P98082	229	447	230	447	Alternative sequence	ID=VSP_004181;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAB2	P98082	229	447	230	232	Sequence conflict	Note=ESK->VCF;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAB2	P98082	229	447	230	232	Sequence conflict	Note=ESK->VCF;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAB2	P98082	229	447	275	275	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAB2	P98082	229	447	302	304	Sequence conflict	Note=QPD->HTR;Ontology_term=ECO:0000305;evidence=ECO:0000305
NEDD9	Q14511	187	221	1	834	Chain	ID=PRO_0000089328;Note=Enhancer of filamentation 1
NEDD9	Q14511	153	187	1	834	Chain	ID=PRO_0000089328;Note=Enhancer of filamentation 1
NEDD9	Q14511	187	221	102	229	Region	Note=Interacts strongly with spindle-regulatory protein D1M1
NEDD9	Q14511	153	187	102	229	Region	Note=Interacts strongly with spindle-regulatory protein D1M1
NEDD9	Q14511	153	187	155	174	Alternative sequence	ID=VSP_042835;Note=In isoform 2. ITPVRTGHGYVYEYPSRYQK->FQRDGQVSYFLVRASKQTSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEDD9	Q14511	187	221	175	834	Alternative sequence	ID=VSP_042836;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEDD9	Q14511	153	187	175	834	Alternative sequence	ID=VSP_042836;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NEDD9	Q14511	153	187	178	178	Natural variant	ID=VAR_054082;Note=D->N;Dbxref=dbSNP:rs11546959
CCDC114	Q96M63	83	124	1	670	Chain	ID=PRO_0000288807;Note=Coiled-coil domain-containing protein 114
CCDC114	Q96M63	83	124	9	155	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC114	Q96M63	83	124	1	207	Alternative sequence	ID=VSP_036212;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC117	Q8IWD4	80	154	1	279	Chain	ID=PRO_0000254138;Note=Coiled-coil domain-containing protein 117
CCDC117	Q8IWD4	80	154	141	168	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC117	Q8IWD4	80	154	12	120	Alternative sequence	ID=VSP_021185;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15461802;Dbxref=PMID:15461802
CCDC117	Q8IWD4	80	154	63	80	Alternative sequence	ID=VSP_054912;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC117	Q8IWD4	80	154	80	155	Alternative sequence	ID=VSP_054913;Note=In isoform 4. DCPVRKKRITEAELCAGPNDWILCAHQDVEGHGVNPSVSGLSIPGILDVICEEMDQTTGEPQCEVARRKLQEIEDR->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC117	Q8IWD4	80	154	147	147	Natural variant	ID=VAR_028823;Note=R->S;Dbxref=dbSNP:rs13057011
CCDC117	Q8IWD4	80	154	102	102	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC136	Q96JN2	115	223	1	1154	Chain	ID=PRO_0000300639;Note=Coiled-coil domain-containing protein 136
CCDC136	Q96JN2	363	416	1	1154	Chain	ID=PRO_0000300639;Note=Coiled-coil domain-containing protein 136
CCDC136	Q96JN2	416	473	1	1154	Chain	ID=PRO_0000300639;Note=Coiled-coil domain-containing protein 136
CCDC136	Q96JN2	535	600	1	1154	Chain	ID=PRO_0000300639;Note=Coiled-coil domain-containing protein 136
CCDC136	Q96JN2	847	921	1	1154	Chain	ID=PRO_0000300639;Note=Coiled-coil domain-containing protein 136
CCDC136	Q96JN2	1015	1121	1	1154	Chain	ID=PRO_0000300639;Note=Coiled-coil domain-containing protein 136
CCDC136	Q96JN2	847	921	859	974	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC136	Q96JN2	115	223	5	337	Compositional bias	Note=Glu-rich
CCDC136	Q96JN2	1015	1121	1036	1110	Compositional bias	Note=Glu-rich
CCDC136	Q96JN2	115	223	212	223	Alternative sequence	ID=VSP_027841;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	363	416	364	1121	Alternative sequence	ID=VSP_027842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	416	473	364	1121	Alternative sequence	ID=VSP_027842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	535	600	364	1121	Alternative sequence	ID=VSP_027842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	847	921	364	1121	Alternative sequence	ID=VSP_027842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	1015	1121	364	1121	Alternative sequence	ID=VSP_027842;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	1015	1121	958	1154	Alternative sequence	ID=VSP_027844;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC136	Q96JN2	115	223	218	218	Natural variant	ID=VAR_034880;Note=D->H;Dbxref=dbSNP:rs3816887
CCDC136	Q96JN2	1015	1121	1049	1049	Natural variant	ID=VAR_034881;Note=Q->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11347906,ECO:0000269|PubMed:12690205,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.5;Dbxref=dbSNP:rs4728137,PMID:11347906,PMID:12690205,PMID:15489334,PMID:17974005
CCDC122	Q5T0U0	185	224	1	273	Chain	ID=PRO_0000286598;Note=Coiled-coil domain-containing protein 122
CCDC122	Q5T0U0	185	224	179	269	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC146	Q8IYE0	80	149	1	955	Chain	ID=PRO_0000317252;Note=Coiled-coil domain-containing protein 146
CCDC146	Q8IYE0	391	423	1	955	Chain	ID=PRO_0000317252;Note=Coiled-coil domain-containing protein 146
CCDC146	Q8IYE0	510	564	1	955	Chain	ID=PRO_0000317252;Note=Coiled-coil domain-containing protein 146
CCDC146	Q8IYE0	716	759	1	955	Chain	ID=PRO_0000317252;Note=Coiled-coil domain-containing protein 146
CCDC146	Q8IYE0	805	888	1	955	Chain	ID=PRO_0000317252;Note=Coiled-coil domain-containing protein 146
CCDC146	Q8IYE0	80	149	114	141	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC146	Q8IYE0	391	423	400	461	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC146	Q8IYE0	510	564	534	640	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC146	Q8IYE0	716	759	667	832	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC146	Q8IYE0	805	888	667	832	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC146	Q8IYE0	80	149	98	103	Compositional bias	Note=Poly-Gln
CCDC146	Q8IYE0	80	149	1	254	Alternative sequence	ID=VSP_030926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
CCDC146	Q8IYE0	391	423	392	423	Alternative sequence	ID=VSP_030927;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
CCDC146	Q8IYE0	805	888	829	829	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC106	Q9BWC9	10	45	1	280	Chain	ID=PRO_0000274343;Note=Coiled-coil domain-containing protein 106
CCDC106	Q9BWC9	10	45	1	280	Chain	ID=PRO_0000274343;Note=Coiled-coil domain-containing protein 106
CCDC106	Q9BWC9	10	45	1	280	Chain	ID=PRO_0000274343;Note=Coiled-coil domain-containing protein 106
CCDC106	Q9BWC9	10	45	1	280	Chain	ID=PRO_0000274343;Note=Coiled-coil domain-containing protein 106
AZI2	Q9H6S1	72	113	1	392	Chain	ID=PRO_0000280602;Note=5-azacytidine-induced protein 2
AZI2	Q9H6S1	72	113	1	197	Region	Note=Homodimerization;Ontology_term=ECO:0000250;evidence=ECO:0000250
AZI2	Q9H6S1	72	113	40	76	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AZI2	Q9H6S1	72	113	102	196	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AZIN1	O14977	222	247	1	448	Chain	ID=PRO_0000149992;Note=Antizyme inhibitor 1
AZIN1	O14977	150	194	1	448	Chain	ID=PRO_0000149992;Note=Antizyme inhibitor 1
AZIN1	O14977	34	92	1	448	Chain	ID=PRO_0000149992;Note=Antizyme inhibitor 1
AZIN1	O14977	222	247	1	448	Chain	ID=PRO_0000149992;Note=Antizyme inhibitor 1
AZIN1	O14977	150	194	1	448	Chain	ID=PRO_0000149992;Note=Antizyme inhibitor 1
AZIN1	O14977	34	92	1	448	Chain	ID=PRO_0000149992;Note=Antizyme inhibitor 1
AZIN1	O14977	34	92	69	69	Site	Note=Not modified;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35484
AZIN1	O14977	34	92	69	69	Site	Note=Not modified;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35484
BAG3	O95817	169	303	2	575	Chain	ID=PRO_0000088868;Note=BAG family molecular chaperone regulator 3
BAG3	O95817	169	303	180	187	Compositional bias	Note=Poly-Ser
BAG3	O95817	169	303	173	173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BAG3	O95817	169	303	198	198	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
BAG3	O95817	169	303	261	261	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLV1
BAG3	O95817	169	303	269	269	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BAG3	O95817	169	303	274	274	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
BAG3	O95817	169	303	275	275	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
BAG3	O95817	169	303	279	279	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
BAG3	O95817	169	303	285	285	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
BAG3	O95817	169	303	289	289	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
BAG3	O95817	169	303	291	291	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
BAG3	O95817	169	303	209	209	Natural variant	ID=VAR_063089;Note=In MFM6%3B interferes with the differentiation of skeletal muscle cells%3B does not cause functional alterations in cardiomyocyte cells. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19085932,ECO:0000269|PubMed:21361913,ECO:0000269|PubMed:21898660;Dbxref=dbSNP:rs121918312,PMID:19085932,PMID:21361913,PMID:21898660
BAG3	O95817	169	303	218	218	Natural variant	ID=VAR_066781;Note=In CMD1HH%3B interferes with the assembly of Z-disks%3B increases stress-induced apoptosis. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898660;Dbxref=dbSNP:rs397514506,PMID:21898660
BAG3	O95817	169	303	258	258	Natural variant	ID=VAR_066782;Note=Polymorphism%3B no functional consequences. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21361913,ECO:0000269|PubMed:21898660;Dbxref=dbSNP:rs117671123,PMID:21361913,PMID:21898660
BAG3	O95817	169	303	300	300	Natural variant	ID=VAR_066783;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898660;Dbxref=dbSNP:rs78439745,PMID:21898660
BAG3	O95817	169	303	227	227	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAG3	O95817	169	303	237	237	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAIAP2	Q9UQB8	43	72	1	552	Chain	ID=PRO_0000064816;Note=Brain-specific angiogenesis inhibitor 1-associated protein 2
BAIAP2	Q9UQB8	93	117	1	552	Chain	ID=PRO_0000064816;Note=Brain-specific angiogenesis inhibitor 1-associated protein 2
BAIAP2	Q9UQB8	43	72	1	250	Domain	Note=IMD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00668
BAIAP2	Q9UQB8	93	117	1	250	Domain	Note=IMD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00668
BAIAP2	Q9UQB8	43	72	24	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKT
BAIAP2	Q9UQB8	43	72	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKT
BAIAP2	Q9UQB8	43	72	70	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKT
BAIAP2	Q9UQB8	93	117	70	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKT
BAIAP2	Q9UQB8	93	117	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKT
BAIAP2	Q9UQB8	93	117	102	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKT
BCKDK	O14874	141	181	31	412	Chain	ID=PRO_0000023452;Note=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase%2C mitochondrial
BCKDK	O14874	239	281	31	412	Chain	ID=PRO_0000023452;Note=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase%2C mitochondrial
BCKDK	O14874	282	311	31	412	Chain	ID=PRO_0000023452;Note=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase%2C mitochondrial
BCKDK	O14874	141	181	31	412	Chain	ID=PRO_0000023452;Note=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase%2C mitochondrial
BCKDK	O14874	239	281	31	412	Chain	ID=PRO_0000023452;Note=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase%2C mitochondrial
BCKDK	O14874	282	311	31	412	Chain	ID=PRO_0000023452;Note=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase%2C mitochondrial
BCKDK	O14874	141	181	159	404	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
BCKDK	O14874	239	281	159	404	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
BCKDK	O14874	282	311	159	404	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
BCKDK	O14874	141	181	159	404	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
BCKDK	O14874	239	281	159	404	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
BCKDK	O14874	282	311	159	404	Domain	Note=Histidine kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00107
BCKDK	O14874	282	311	282	311	Alternative sequence	ID=VSP_054604;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BCKDK	O14874	282	311	282	311	Alternative sequence	ID=VSP_054604;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BCKDK	O14874	141	181	174	174	Natural variant	ID=VAR_072184;Note=In BCKDKD%3B partial loss of kinase activity. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24449431;Dbxref=PMID:24449431
BCKDK	O14874	141	181	174	174	Natural variant	ID=VAR_072184;Note=In BCKDKD%3B partial loss of kinase activity. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24449431;Dbxref=PMID:24449431
BEST1	O76090	238	289	1	585	Chain	ID=PRO_0000143114;Note=Bestrophin-1
BEST1	O76090	289	316	1	585	Chain	ID=PRO_0000143114;Note=Bestrophin-1
BEST1	O76090	238	289	229	249	Intramembrane	Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST1	O76090	238	289	250	270	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST1	O76090	238	289	271	291	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST1	O76090	289	316	271	291	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST1	O76090	289	316	292	585	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST1	O76090	289	316	290	316	Alternative sequence	ID=VSP_008975;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BEST1	O76090	238	289	239	239	Natural variant	ID=VAR_058276;Note=In ADVIRC. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15452077;Dbxref=dbSNP:rs121918290,PMID:15452077
BEST1	O76090	238	289	241	241	Natural variant	ID=VAR_025738;Note=In VMD2. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14517959;Dbxref=dbSNP:rs281865247,PMID:14517959
BEST1	O76090	238	289	242	242	Natural variant	ID=VAR_058277;Note=In VMD2%3B late-onset of visual disturbance. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18766995;Dbxref=PMID:18766995
BEST1	O76090	238	289	243	243	Natural variant	ID=VAR_025739;Note=In VMD2. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs137853905,PMID:10798642
BEST1	O76090	238	289	243	243	Natural variant	ID=VAR_000858;Note=In VMD2. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19357557;Dbxref=dbSNP:rs28940570,PMID:19357557
BEST1	O76090	238	289	275	275	Natural variant	ID=VAR_025740;Note=In age-related macular degeneration. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865276,PMID:10798642
BEST1	O76090	238	289	276	276	Natural variant	ID=VAR_025741;Note=In VMD2. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865248,PMID:10798642
BEST1	O76090	289	316	293	293	Natural variant	ID=VAR_010483;Note=In VMD2. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10394929;Dbxref=dbSNP:rs281865250,PMID:10394929
BEST1	O76090	289	316	294	294	Natural variant	ID=VAR_025742;Note=In VMD2. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14517959;Dbxref=dbSNP:rs281865251,PMID:14517959
BEST1	O76090	289	316	295	295	Natural variant	ID=VAR_025743;Note=In VMD2. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12187431;Dbxref=dbSNP:rs281865253,PMID:12187431
BEST1	O76090	289	316	295	295	Natural variant	ID=VAR_000859;Note=In VMD2. Missing
BEST1	O76090	289	316	296	296	Natural variant	ID=VAR_025744;Note=In VMD2. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865254,PMID:10798642
BEST1	O76090	289	316	296	296	Natural variant	ID=VAR_010484;Note=In VMD2. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11241846;Dbxref=dbSNP:rs281865255,PMID:11241846
BEST1	O76090	289	316	297	297	Natural variant	ID=VAR_000860;Note=In VMD2. P->A;Dbxref=dbSNP:rs1805143
BEST1	O76090	289	316	297	297	Natural variant	ID=VAR_010485;Note=In VMD2. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10453731,ECO:0000269|PubMed:13129869;Dbxref=dbSNP:rs1805143,PMID:10453731,PMID:13129869
BEST1	O76090	289	316	298	298	Natural variant	ID=VAR_025745;Note=In VMD2. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14517959;Dbxref=dbSNP:rs281865257,PMID:14517959
BEST1	O76090	289	316	299	299	Natural variant	ID=VAR_058313;Note=In VMD2. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19357557;Dbxref=PMID:19357557
BEST1	O76090	289	316	299	299	Natural variant	ID=VAR_000861;Note=In VMD2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9662395;Dbxref=dbSNP:rs28941468,PMID:9662395
BEST1	O76090	289	316	300	300	Natural variant	ID=VAR_010486;Note=In VMD2. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10331951,ECO:0000269|PubMed:10453731,ECO:0000269|PubMed:13129869;Dbxref=dbSNP:rs1805144,PMID:10331951,PMID:10453731,PMID:13129869
BEST1	O76090	289	316	300	300	Natural variant	ID=VAR_000862;Note=In VMD2. E->K;Dbxref=dbSNP:rs281865258
BEST1	O76090	289	316	301	301	Natural variant	ID=VAR_000863;Note=In VMD2. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10331951;Dbxref=dbSNP:rs281865261,PMID:10331951
BEST1	O76090	289	316	301	301	Natural variant	ID=VAR_000864;Note=In VMD2. D->N;Dbxref=dbSNP:rs281865259
BEST1	O76090	289	316	302	304	Natural variant	ID=VAR_058278;Note=In VMD2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19357557;Dbxref=PMID:19357557
BEST1	O76090	289	316	302	302	Natural variant	ID=VAR_025746;Note=In VMD2. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865263,PMID:10798642
BEST1	O76090	289	316	302	302	Natural variant	ID=VAR_025747;Note=In VMD2. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12324875;Dbxref=dbSNP:rs281865262,PMID:12324875
BEST1	O76090	289	316	302	302	Natural variant	ID=VAR_025748;Note=In VMD2. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865263,PMID:10798642
BEST1	O76090	289	316	303	303	Natural variant	ID=VAR_025749;Note=In VMD2. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12324875;Dbxref=dbSNP:rs281865264,PMID:12324875
BEST1	O76090	289	316	305	305	Natural variant	ID=VAR_000865;Note=In VMD2. F->S;Dbxref=dbSNP:rs281865265
BEST1	O76090	289	316	306	306	Natural variant	ID=VAR_025750;Note=In VMD2. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865267,PMID:10798642
BEST1	O76090	289	316	306	306	Natural variant	ID=VAR_025751;Note=In VMD2. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865266,PMID:10798642
BEST1	O76090	289	316	307	307	Natural variant	ID=VAR_025752;Note=In VMD2. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10798642;Dbxref=dbSNP:rs281865268,PMID:10798642
BEST1	O76090	289	316	307	307	Natural variant	ID=VAR_010487;Note=In VMD2. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10331951;Dbxref=dbSNP:rs281865269,PMID:10331951
BEST1	O76090	289	316	308	308	Natural variant	ID=VAR_025753;Note=In VMD2. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12324875;Dbxref=dbSNP:rs281865270,PMID:12324875
BEST1	O76090	289	316	310	310	Natural variant	ID=VAR_000866;Note=In VMD2. I->T;Dbxref=dbSNP:rs281865271
BEST1	O76090	289	316	311	311	Natural variant	ID=VAR_000867;Note=In VMD2. V->G
BEST1	O76090	289	316	312	312	Natural variant	ID=VAR_000868;Note=In VMD2 and ARB%3B no effect on protein stability%3B loss of cell membrane localization in transfected MDCK.2 cells%3B reduced chloride conductance. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18179881,ECO:0000269|PubMed:19853238,ECO:0000269|PubMed:21330666;Dbxref=dbSNP:rs281865277,PMID:18179881,PMID:19853238,PMID:21330666
BHMT2	Q9H2M3	86	150	1	363	Chain	ID=PRO_0000273224;Note=S-methylmethionine--homocysteine S-methyltransferase BHMT2
BHMT2	Q9H2M3	199	260	1	363	Chain	ID=PRO_0000273224;Note=S-methylmethionine--homocysteine S-methyltransferase BHMT2
BHMT2	Q9H2M3	86	150	11	305	Domain	Note=Hcy-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00333
BHMT2	Q9H2M3	199	260	11	305	Domain	Note=Hcy-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00333
BHMT2	Q9H2M3	199	260	208	208	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00333
BHMT2	Q9H2M3	86	150	87	150	Alternative sequence	ID=VSP_042938;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BMP2K	Q9NSY1	650	687	1	1161	Chain	ID=PRO_0000085663;Note=BMP-2-inducible protein kinase
BMP2K	Q9NSY1	650	687	651	662	Alternative sequence	ID=VSP_008091;Note=In isoform 2 and isoform 3. NRLEERASSDKN->SKGHLKAYFASQ;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.5;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
BMP2K	Q9NSY1	650	687	663	1161	Alternative sequence	ID=VSP_008092;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.5;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
BOC	Q9BWV1	174	222	31	1114	Chain	ID=PRO_0000234052;Note=Brother of CDO
BOC	Q9BWV1	320	411	31	1114	Chain	ID=PRO_0000234052;Note=Brother of CDO
BOC	Q9BWV1	810	884	31	1114	Chain	ID=PRO_0000234052;Note=Brother of CDO
BOC	Q9BWV1	174	222	31	1114	Chain	ID=PRO_0000234052;Note=Brother of CDO
BOC	Q9BWV1	320	411	31	1114	Chain	ID=PRO_0000234052;Note=Brother of CDO
BOC	Q9BWV1	810	884	31	1114	Chain	ID=PRO_0000234052;Note=Brother of CDO
BOC	Q9BWV1	174	222	31	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	320	411	31	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	810	884	31	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	174	222	31	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	320	411	31	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	810	884	31	855	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	810	884	856	876	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	810	884	856	876	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	810	884	877	1114	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	810	884	877	1114	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	174	222	129	213	Domain	Note=Ig-like C2-type 2
BOC	Q9BWV1	174	222	129	213	Domain	Note=Ig-like C2-type 2
BOC	Q9BWV1	320	411	323	409	Domain	Note=Ig-like C2-type 4
BOC	Q9BWV1	320	411	323	409	Domain	Note=Ig-like C2-type 4
BOC	Q9BWV1	810	884	712	812	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
BOC	Q9BWV1	810	884	712	812	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
BOC	Q9BWV1	174	222	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	174	222	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BOC	Q9BWV1	174	222	150	200	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BOC	Q9BWV1	174	222	150	200	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BOC	Q9BWV1	320	411	344	391	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BOC	Q9BWV1	320	411	344	391	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
BOC	Q9BWV1	174	222	1	183	Alternative sequence	ID=VSP_037603;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BOC	Q9BWV1	174	222	1	183	Alternative sequence	ID=VSP_037603;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BOC	Q9BWV1	174	222	184	223	Alternative sequence	ID=VSP_037604;Note=In isoform 2. NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRR->KTRNGCLIPSPCSLGLPPGHALQDILVHTPSVLALLAPPG;Ontology_term=ECO:0000305;evidence=ECO:0000305
BOC	Q9BWV1	174	222	184	223	Alternative sequence	ID=VSP_037604;Note=In isoform 2. NLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRR->KTRNGCLIPSPCSLGLPPGHALQDILVHTPSVLALLAPPG;Ontology_term=ECO:0000305;evidence=ECO:0000305
BOC	Q9BWV1	810	884	883	883	Natural variant	ID=VAR_033600;Note=K->N;Dbxref=dbSNP:rs35536878
BOC	Q9BWV1	810	884	883	883	Natural variant	ID=VAR_033600;Note=K->N;Dbxref=dbSNP:rs35536878
BPHL	Q86WA6	177	221	38	291	Chain	ID=PRO_0000017841;Note=Valacyclovir hydrolase
BPHL	Q86WA6	177	221	62	181	Domain	Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255
BPHL	Q86WA6	177	221	184	184	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R164
BPHL	Q86WA6	177	221	191	191	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R164
BPHL	Q86WA6	177	221	191	191	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R164
BPHL	Q86WA6	177	221	217	217	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8R164
BPHL	Q86WA6	177	221	182	182	Sequence conflict	Note=V->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
BPHL	Q86WA6	177	221	170	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OCG
BPHL	Q86WA6	177	221	182	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OCG
BPHL	Q86WA6	177	221	187	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OCG
BPHL	Q86WA6	177	221	199	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OCG
BPHL	Q86WA6	177	221	215	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OCG
BPHL	Q86WA6	177	221	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OCG
B4GALT6	Q9UBX8	157	196	1	382	Chain	ID=PRO_0000080547;Note=Beta-1%2C4-galactosyltransferase 6
B4GALT6	Q9UBX8	77	115	1	382	Chain	ID=PRO_0000080547;Note=Beta-1%2C4-galactosyltransferase 6
B4GALT6	Q9UBX8	38	77	1	382	Chain	ID=PRO_0000080547;Note=Beta-1%2C4-galactosyltransferase 6
B4GALT6	Q9UBX8	157	196	36	382	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	77	115	36	382	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	38	77	36	382	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	157	196	163	167	Region	Note=UDP-alpha-D-galactose binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT6	Q9UBX8	38	77	71	71	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	38	77	75	75	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	77	115	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	77	115	84	84	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	77	115	99	99	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT6	Q9UBX8	77	115	108	152	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT6	Q9UBX8	157	196	158	196	Alternative sequence	ID=VSP_056554;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
B4GALT6	Q9UBX8	157	196	194	194	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIK3AP1	Q6ZUJ8	671	723	1	805	Chain	ID=PRO_0000341273;Note=Phosphoinositide 3-kinase adapter protein 1
PIK3AP1	Q6ZUJ8	671	723	694	694	Modified residue	Note=Phosphotyrosine%3B by ABL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15893754;Dbxref=PMID:15893754
PIK3AP1	Q6ZUJ8	671	723	718	718	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BCO2	Q9BYV7	398	444	1	579	Chain	ID=PRO_0000143937;Note=Beta%2Cbeta-carotene 9'%2C10'-oxygenase
BCO2	Q9BYV7	444	505	1	579	Chain	ID=PRO_0000143937;Note=Beta%2Cbeta-carotene 9'%2C10'-oxygenase
BCO2	Q9BYV7	444	505	501	506	Alternative sequence	ID=VSP_008600;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BCO2	Q9BYV7	398	444	429	429	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCO2	Q9BYV7	444	505	446	446	Sequence conflict	Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZNHIT6	Q9NWK9	219	240	1	470	Chain	ID=PRO_0000280239;Note=Box C/D snoRNA protein 1
ZNHIT6	Q9NWK9	219	240	220	254	Zinc finger	Note=HIT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453
BCL9L	Q86UU0	1041	1135	1	1499	Chain	ID=PRO_0000314079;Note=B-cell CLL/lymphoma 9-like protein
BCL9L	Q86UU0	1041	1135	891	1378	Compositional bias	Note=Pro-rich
BEAN1	Q3B7T3	8	96	1	259	Chain	ID=PRO_0000322540;Note=Protein BEAN1
BEAN1	Q3B7T3	8	96	36	56	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEAN1	Q3B7T3	8	96	60	111	Compositional bias	Note=Arg-rich
BEAN1	Q3B7T3	8	96	70	101	Compositional bias	Note=His-rich
BEAN1	Q3B7T3	8	96	1	109	Alternative sequence	ID=VSP_031911;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:19878914;Dbxref=PMID:14702039,PMID:15489334,PMID:19878914
GUSB	P08236	492	551	23	651	Chain	ID=PRO_0000012161;Note=Beta-glucuronidase
GUSB	P08236	304	355	23	651	Chain	ID=PRO_0000012161;Note=Beta-glucuronidase
GUSB	P08236	304	355	159	304	Alternative sequence	ID=VSP_054830;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
GUSB	P08236	304	355	305	355	Alternative sequence	ID=VSP_001799;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
GUSB	P08236	304	355	320	320	Natural variant	ID=VAR_037921;Note=In MPS7. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8644704;Dbxref=PMID:8644704
GUSB	P08236	304	355	320	320	Natural variant	ID=VAR_037922;Note=In MPS7. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8644704;Dbxref=dbSNP:rs886044680,PMID:8644704
GUSB	P08236	304	355	339	339	Natural variant	ID=VAR_058514;Note=In MPS7. N->S
GUSB	P08236	304	355	350	350	Natural variant	ID=VAR_037923;Note=In MPS7. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12522561;Dbxref=dbSNP:rs121918182,PMID:12522561
GUSB	P08236	304	355	351	351	Natural variant	ID=VAR_037924;Note=In MPS7. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8644704;Dbxref=dbSNP:rs191153460,PMID:8644704
GUSB	P08236	304	355	354	354	Natural variant	ID=VAR_003197;Note=In MPS7. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8111413;Dbxref=dbSNP:rs121918175,PMID:8111413
GUSB	P08236	492	551	495	495	Natural variant	ID=VAR_037931;Note=In MPS7. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7633414;Dbxref=dbSNP:rs121918178,PMID:7633414
GUSB	P08236	492	551	508	508	Natural variant	ID=VAR_037932;Note=In MPS7. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8644704;Dbxref=PMID:8644704
GUSB	P08236	492	551	540	540	Natural variant	ID=VAR_058518;Note=In MPS7. E->K
GUSB	P08236	304	355	301	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	304	355	314	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	304	355	329	331	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	304	355	336	338	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	304	355	341	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	304	355	345	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	304	355	355	357	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	493	495	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	497	502	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	505	507	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	508	510	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	514	516	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	517	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
GUSB	P08236	492	551	536	540	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HN3
BID	P55957	121	192	1	195	Chain	ID=PRO_0000143101;Note=BH3-interacting domain death agonist
BID	P55957	121	192	1	195	Chain	ID=PRO_0000143101;Note=BH3-interacting domain death agonist
BID	P55957	121	192	62	195	Chain	ID=PRO_0000223233;Note=BH3-interacting domain death agonist p15;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70444
BID	P55957	121	192	62	195	Chain	ID=PRO_0000223233;Note=BH3-interacting domain death agonist p15;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70444
BID	P55957	121	192	77	195	Chain	ID=PRO_0000223232;Note=BH3-interacting domain death agonist p13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70444
BID	P55957	121	192	77	195	Chain	ID=PRO_0000223232;Note=BH3-interacting domain death agonist p13;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70444
BID	P55957	121	192	100	195	Chain	ID=PRO_0000223231;Note=BH3-interacting domain death agonist p11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70444
BID	P55957	121	192	100	195	Chain	ID=PRO_0000223231;Note=BH3-interacting domain death agonist p11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70444
BID	P55957	121	192	75	137	Alternative sequence	ID=VSP_017268;Note=In isoform 3. DSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQA->GASDNNTASAEEETEAAGSVAVERGLHGAATVILKVKKTSSGILPGTSPRSGTAWTVASLRAW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14583606;Dbxref=PMID:14583606
BID	P55957	121	192	75	137	Alternative sequence	ID=VSP_017268;Note=In isoform 3. DSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQA->GASDNNTASAEEETEAAGSVAVERGLHGAATVILKVKKTSSGILPGTSPRSGTAWTVASLRAW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14583606;Dbxref=PMID:14583606
BID	P55957	121	192	138	195	Alternative sequence	ID=VSP_017269;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14583606;Dbxref=PMID:14583606
BID	P55957	121	192	138	195	Alternative sequence	ID=VSP_017269;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14583606;Dbxref=PMID:14583606
BID	P55957	121	192	162	162	Natural variant	ID=VAR_025332;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853595,PMID:15489334
BID	P55957	121	192	162	162	Natural variant	ID=VAR_025332;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853595,PMID:15489334
BID	P55957	121	192	119	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	119	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	145	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	145	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	167	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	167	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	183	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BID	P55957	121	192	183	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BID
BICD1	Q96G01	193	335	1	975	Chain	ID=PRO_0000205357;Note=Protein bicaudal D homolog 1
BICD1	Q96G01	335	700	1	975	Chain	ID=PRO_0000205357;Note=Protein bicaudal D homolog 1
BICD1	Q96G01	335	700	663	803	Region	Note=Interaction with RAB6A
BICD1	Q96G01	193	335	1	265	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BICD1	Q96G01	193	335	319	496	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BICD1	Q96G01	335	700	319	496	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BICD1	Q96G01	335	700	663	803	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BICD1	Q96G01	193	335	94	975	Alternative sequence	ID=VSP_007962;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BICD1	Q96G01	335	700	94	975	Alternative sequence	ID=VSP_007962;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BICD1	Q96G01	335	700	588	588	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BLMH	Q13867	215	267	1	455	Chain	ID=PRO_0000050550;Note=Bleomycin hydrolase
BLMH	Q13867	215	267	202	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BLMH	Q13867	215	267	229	236	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BLMH	Q13867	215	267	242	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BLMH	Q13867	215	267	250	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BLMH	Q13867	215	267	258	261	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BLMH	Q13867	215	267	264	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BLMH	Q13867	215	267	267	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CB5
BRAP	Q7Z569	407	437	1	592	Chain	ID=PRO_0000055825;Note=BRCA1-associated protein
BRAP	Q7Z569	211	249	1	592	Chain	ID=PRO_0000055825;Note=BRCA1-associated protein
BRAP	Q7Z569	407	437	429	537	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BRAP	Q7Z569	211	249	212	249	Alternative sequence	ID=VSP_055882;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AUH	Q13825	298	314	68	339	Chain	ID=PRO_0000007415;Note=Methylglutaconyl-CoA hydratase%2C mitochondrial
AUH	Q13825	281	298	68	339	Chain	ID=PRO_0000007415;Note=Methylglutaconyl-CoA hydratase%2C mitochondrial
AUH	Q13825	199	218	68	339	Chain	ID=PRO_0000007415;Note=Methylglutaconyl-CoA hydratase%2C mitochondrial
AUH	Q13825	168	199	68	339	Chain	ID=PRO_0000007415;Note=Methylglutaconyl-CoA hydratase%2C mitochondrial
AUH	Q13825	139	168	68	339	Chain	ID=PRO_0000007415;Note=Methylglutaconyl-CoA hydratase%2C mitochondrial
AUH	Q13825	139	168	144	144	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	139	168	144	144	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	139	168	148	148	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	139	168	160	160	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	199	218	204	204	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	199	218	204	204	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	199	218	211	211	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	199	218	211	211	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLZ3
AUH	Q13825	168	199	140	168	Alternative sequence	ID=VSP_008336;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AUH	Q13825	139	168	140	168	Alternative sequence	ID=VSP_008336;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AUH	Q13825	139	168	143	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	168	199	151	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	139	168	151	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	168	199	175	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	168	199	186	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	199	218	194	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	168	199	194	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	199	218	204	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	199	218	209	212	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	281	298	283	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	298	314	301	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AUH	Q13825	298	314	314	317	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HZD
AVIL	O75366	740	782	1	819	Chain	ID=PRO_0000218736;Note=Advillin
AVIL	O75366	654	717	1	819	Chain	ID=PRO_0000218736;Note=Advillin
AVIL	O75366	654	717	628	669	Repeat	Note=Gelsolin-like 6
AVIL	O75366	740	782	753	819	Domain	Note=HP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00595
AVIL	O75366	654	717	1	731	Region	Note=Core;Ontology_term=ECO:0000250;evidence=ECO:0000250
AVIL	O75366	740	782	731	819	Region	Note=Headpiece;Ontology_term=ECO:0000250;evidence=ECO:0000250
AVIL	O75366	740	782	758	758	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88398
BCL2L13	Q9BXK5	40	76	1	485	Chain	ID=PRO_0000143073;Note=Bcl-2-like protein 13
BCL2L13	Q9BXK5	152	200	1	485	Chain	ID=PRO_0000143073;Note=Bcl-2-like protein 13
BCL2L13	Q9BXK5	152	200	147	157	Motif	Note=BH1
BCL2L13	Q9BXK5	152	200	193	206	Motif	Note=BH2
BCL2L13	Q9BXK5	40	76	1	162	Alternative sequence	ID=VSP_046931;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BCL2L13	Q9BXK5	152	200	1	162	Alternative sequence	ID=VSP_046931;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BCL2L13	Q9BXK5	40	76	46	46	Natural variant	ID=VAR_059141;Note=I->R;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=dbSNP:rs2587070,PMID:18669648
BCL2L13	Q9BXK5	40	76	46	46	Natural variant	ID=VAR_059142;Note=I->T;Dbxref=dbSNP:rs2587070
BCL2L13	Q9BXK5	40	76	55	55	Natural variant	ID=VAR_024377;Note=I->V;Dbxref=dbSNP:rs16981016
BCL2L13	Q9BXK5	152	200	170	170	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
B3GNTL1	Q67FW5	287	310	1	361	Chain	ID=PRO_0000289220;Note=UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase-like protein 1
B3GNTL1	Q67FW5	168	200	1	361	Chain	ID=PRO_0000289220;Note=UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase-like protein 1
B3GNTL1	Q67FW5	136	168	1	361	Chain	ID=PRO_0000289220;Note=UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase-like protein 1
B3GNTL1	Q67FW5	114	136	1	361	Chain	ID=PRO_0000289220;Note=UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase-like protein 1
B3GNTL1	Q67FW5	20	59	1	361	Chain	ID=PRO_0000289220;Note=UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase-like protein 1
B4GALNT1	Q00973	237	270	1	533	Chain	ID=PRO_0000059100;Note=Beta-1%2C4 N-acetylgalactosaminyltransferase 1
B4GALNT1	Q00973	73	127	1	533	Chain	ID=PRO_0000059100;Note=Beta-1%2C4 N-acetylgalactosaminyltransferase 1
B4GALNT1	Q00973	237	270	26	533	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALNT1	Q00973	73	127	26	533	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALNT1	Q00973	73	127	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALNT1	Q00973	73	127	80	80	Disulfide bond	Note=Interchain (with C-412);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11018043;Dbxref=PMID:11018043
B4GALNT1	Q00973	73	127	82	82	Disulfide bond	Note=Interchain (with C-529);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11018043;Dbxref=PMID:11018043
B4GALNT1	Q00973	73	127	74	128	Alternative sequence	ID=VSP_055039;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
B4GALNT1	Q00973	237	270	238	328	Alternative sequence	ID=VSP_055040;Note=In isoform 3. VRFSTEGHEAAFTIRIRHPPNPRLYPPGSLPQGAQYNISALVTIATKTFLRYDRLRALITSIRRFYPTVTVVIADDSDKPERVSGPYVEHY->GARPGWRDGQAGQTEKNQKGWSGQMAEGMGGIWAMARAVQPHNGCFNWTSRARGRKGAFVHLGLEQARGKPEPWVCLPFRPTVGGPRKRLV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BAP1	Q92560	630	661	1	729	Chain	ID=PRO_0000211069;Note=Ubiquitin carboxyl-terminal hydrolase BAP1
BAP1	Q92560	630	661	596	721	Region	Note=Interaction with BRCA1
BAP1	Q92560	630	661	630	661	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BAP1	Q92560	630	661	656	661	Mutagenesis	Note=Does not affect nuclear localization. KRKKFK->AAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18757409;Dbxref=PMID:18757409
BAZ1A	Q9NRL2	503	535	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	454	503	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	376	408	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	242	287	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	179	212	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	131	178	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	38	130	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	503	535	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	454	503	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	376	408	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	242	287	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	179	212	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	131	178	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	38	130	1	1556	Chain	ID=PRO_0000211167;Note=Bromodomain adjacent to zinc finger domain protein 1A
BAZ1A	Q9NRL2	38	130	22	128	Domain	Note=WAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00475
BAZ1A	Q9NRL2	38	130	22	128	Domain	Note=WAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00475
BAZ1A	Q9NRL2	454	503	422	487	Domain	Note=DDT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00063
BAZ1A	Q9NRL2	454	503	422	487	Domain	Note=DDT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00063
BAZ1A	Q9NRL2	131	178	1	133	Region	Note=Required for interaction with NCOR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17519354;Dbxref=PMID:17519354
BAZ1A	Q9NRL2	38	130	1	133	Region	Note=Required for interaction with NCOR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17519354;Dbxref=PMID:17519354
BAZ1A	Q9NRL2	131	178	1	133	Region	Note=Required for interaction with NCOR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17519354;Dbxref=PMID:17519354
BAZ1A	Q9NRL2	38	130	1	133	Region	Note=Required for interaction with NCOR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17519354;Dbxref=PMID:17519354
BAZ1A	Q9NRL2	38	130	1	128	Region	Note=Required for association with the CHRAC1/POLE3 complex
BAZ1A	Q9NRL2	38	130	1	128	Region	Note=Required for association with the CHRAC1/POLE3 complex
BAZ1A	Q9NRL2	376	408	306	397	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BAZ1A	Q9NRL2	376	408	306	397	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BAZ1A	Q9NRL2	454	503	487	491	Compositional bias	Note=Poly-Glu
BAZ1A	Q9NRL2	454	503	487	491	Compositional bias	Note=Poly-Glu
BAZ1A	Q9NRL2	242	287	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
BAZ1A	Q9NRL2	242	287	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
BAZ1A	Q9NRL2	503	535	504	535	Alternative sequence	ID=VSP_000551;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10655480;Dbxref=PMID:10655480
BAZ1A	Q9NRL2	503	535	504	535	Alternative sequence	ID=VSP_000551;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10655480;Dbxref=PMID:10655480
BAZ1A	Q9NRL2	131	178	135	135	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	131	178	135	135	Sequence conflict	Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	454	503	494	494	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	454	503	494	494	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	503	535	503	508	Sequence conflict	Note=KDLTEA->QDFTEP;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	454	503	503	508	Sequence conflict	Note=KDLTEA->QDFTEP;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	503	535	503	508	Sequence conflict	Note=KDLTEA->QDFTEP;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	454	503	503	508	Sequence conflict	Note=KDLTEA->QDFTEP;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	503	535	525	525	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ1A	Q9NRL2	503	535	525	525	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BBS4	Q96RK4	135	153	1	519	Chain	ID=PRO_0000106263;Note=Bardet-Biedl syndrome 4 protein
BBS4	Q96RK4	214	237	1	519	Chain	ID=PRO_0000106263;Note=Bardet-Biedl syndrome 4 protein
BBS4	Q96RK4	135	153	135	168	Repeat	Note=TPR 3
BBS4	Q96RK4	214	237	203	235	Repeat	Note=TPR 5
BBS4	Q96RK4	214	237	237	269	Repeat	Note=TPR 6
BBS4	Q96RK4	135	153	101	337	Region	Note=Interaction with PCM1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15107855;Dbxref=PMID:15107855
BBS4	Q96RK4	214	237	101	337	Region	Note=Interaction with PCM1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15107855;Dbxref=PMID:15107855
BBS4	Q96RK4	135	153	1	172	Alternative sequence	ID=VSP_047507;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BAZ2A	Q9UIF9	1677	1726	1	1905	Chain	ID=PRO_0000211172;Note=Bromodomain adjacent to zinc finger domain protein 2A
BAZ2A	Q9UIF9	990	1014	1	1905	Chain	ID=PRO_0000211172;Note=Bromodomain adjacent to zinc finger domain protein 2A
BAZ2A	Q9UIF9	307	380	1	1905	Chain	ID=PRO_0000211172;Note=Bromodomain adjacent to zinc finger domain protein 2A
BAZ2A	Q9UIF9	47	245	1	1905	Chain	ID=PRO_0000211172;Note=Bromodomain adjacent to zinc finger domain protein 2A
BAZ2A	Q9UIF9	1	47	1	1905	Chain	ID=PRO_0000211172;Note=Bromodomain adjacent to zinc finger domain protein 2A
BAZ2A	Q9UIF9	1677	1726	1676	1726	Zinc finger	Note=PHD-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
BAZ2A	Q9UIF9	1677	1726	1709	1709	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BAZ2A	Q9UIF9	1	47	6	6	Alternative sequence	ID=VSP_037960;Note=In isoform 1. N->NEAN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662543;Dbxref=PMID:10662543
BAZ2A	Q9UIF9	47	245	178	207	Alternative sequence	ID=VSP_019111;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662543;Dbxref=PMID:10662543
BAZ2A	Q9UIF9	47	245	106	106	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2A	Q9UIF9	47	245	148	148	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2A	Q9UIF9	47	245	155	155	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2A	Q9UIF9	47	245	207	207	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2A	Q9UIF9	47	245	210	210	Sequence conflict	Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2A	Q9UIF9	47	245	236	236	Sequence conflict	Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2A	Q9UIF9	1677	1726	1680	1682	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BAZ2A	Q9UIF9	1677	1726	1688	1690	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BAZ2A	Q9UIF9	1677	1726	1691	1693	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BAZ2A	Q9UIF9	1677	1726	1695	1698	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BAZ2A	Q9UIF9	1677	1726	1700	1702	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BAZ2A	Q9UIF9	1677	1726	1703	1705	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BAZ2A	Q9UIF9	1677	1726	1721	1724	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QF2
BCCIP	Q9P287	107	137	1	314	Chain	ID=PRO_0000249687;Note=BRCA2 and CDKN1A-interacting protein
BCCIP	Q9P287	107	137	59	167	Region	Note=Interaction with BRCA2
BCCIP	Q9P287	107	137	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ATXN10	Q9UBB4	39	102	1	475	Chain	ID=PRO_0000064748;Note=Ataxin-10
ATXN10	Q9UBB4	216	242	1	475	Chain	ID=PRO_0000064748;Note=Ataxin-10
ATXN10	Q9UBB4	39	102	40	103	Alternative sequence	ID=VSP_042526;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CYB5A	P00167	86	96	2	134	Chain	ID=PRO_0000166010;Note=Cytochrome b5
CYB5A	P00167	86	96	86	95	Alternative sequence	ID=VSP_045367;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CYB5A	P00167	86	96	27	134	Natural variant	ID=VAR_080833;Note=In METAG. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20080843;Dbxref=PMID:20080843
CYB5A	P00167	86	96	89	91	Sequence conflict	Note=RPK->KPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYB5A	P00167	86	96	89	91	Sequence conflict	Note=RPK->KPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYB5A	P00167	86	96	89	91	Sequence conflict	Note=RPK->KPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYB5A	P00167	86	96	89	91	Sequence conflict	Note=RPK->KPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYB5A	P00167	86	96	86	88	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I96
CYB5A	P00167	86	96	91	93	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I96
CYB5A	P00167	86	96	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I96
TAT	P17735	375	408	1	454	Chain	ID=PRO_0000123887;Note=Tyrosine aminotransferase
TAT	P17735	347	375	1	454	Chain	ID=PRO_0000123887;Note=Tyrosine aminotransferase
TAT	P17735	304	347	1	454	Chain	ID=PRO_0000123887;Note=Tyrosine aminotransferase
TAT	P17735	253	304	1	454	Chain	ID=PRO_0000123887;Note=Tyrosine aminotransferase
TAT	P17735	253	304	280	280	Modified residue	Note=N6-(pyridoxal phosphate)lysine
TAT	P17735	347	375	362	362	Natural variant	ID=VAR_000560;Note=In TYRSN2. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1357662;Dbxref=dbSNP:rs587776511,PMID:1357662
TAT	P17735	253	304	294	294	Mutagenesis	Note=Reduced catalytic activity. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16640556;Dbxref=PMID:16640556
TAT	P17735	253	304	263	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	253	304	272	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	253	304	279	281	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	253	304	285	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	253	304	290	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	304	347	302	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	253	304	302	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	304	347	321	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	347	375	336	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	304	347	336	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	347	375	363	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	375	408	373	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	347	375	373	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	375	408	380	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	375	408	389	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
TAT	P17735	375	408	407	410	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DYD
AVEN	Q9NQS1	172	204	1	362	Chain	ID=PRO_0000064768;Note=Cell death regulator Aven
AVL9	Q8NBF6	100	124	1	648	Chain	ID=PRO_0000247178;Note=Late secretory pathway protein AVL9 homolog
AVL9	Q8NBF6	124	154	1	648	Chain	ID=PRO_0000247178;Note=Late secretory pathway protein AVL9 homolog
AVL9	Q8NBF6	405	450	1	648	Chain	ID=PRO_0000247178;Note=Late secretory pathway protein AVL9 homolog
AVL9	Q8NBF6	563	580	1	648	Chain	ID=PRO_0000247178;Note=Late secretory pathway protein AVL9 homolog
AVL9	Q8NBF6	100	124	17	161	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
AVL9	Q8NBF6	124	154	17	161	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
AVL9	Q8NBF6	405	450	342	593	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
AVL9	Q8NBF6	563	580	342	593	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
AVL9	Q8NBF6	563	580	524	589	Alternative sequence	ID=VSP_019943;Note=In isoform 2. DNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNHPFQGQYSVSDMKLRFSHSVQNSERG->VLFRIVNVA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9039502;Dbxref=PMID:9039502
AXDND1	Q5T1B0	796	832	1	1012	Chain	ID=PRO_0000284868;Note=Axonemal dynein light chain domain-containing protein 1
AXDND1	Q5T1B0	796	832	824	1002	Compositional bias	Note=Glu-rich
AXDND1	Q5T1B0	796	832	656	1012	Alternative sequence	ID=VSP_024706;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AXIN2	Q9Y2T1	714	745	1	843	Chain	ID=PRO_0000220895;Note=Axin-2
AXIN2	Q9Y2T1	571	635	1	843	Chain	ID=PRO_0000220895;Note=Axin-2
AXIN2	Q9Y2T1	571	635	572	636	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANK1	Q8NDB2	23	156	1	785	Chain	ID=PRO_0000251927;Note=B-cell scaffold protein with ankyrin repeats
BANK1	Q8NDB2	531	633	1	785	Chain	ID=PRO_0000251927;Note=B-cell scaffold protein with ankyrin repeats
BANK1	Q8NDB2	23	156	1	154	Region	Note=Interaction with ITPR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11782428;Dbxref=PMID:11782428
BANK1	Q8NDB2	23	156	1	30	Alternative sequence	ID=VSP_020803;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11782428,ECO:0000303|PubMed:14702039;Dbxref=PMID:11782428,PMID:14702039
BANK1	Q8NDB2	23	156	15	23	Alternative sequence	ID=VSP_020805;Note=In isoform 2. PAPCGPAPP->MVNCHLKI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BANK1	Q8NDB2	23	156	24	156	Alternative sequence	ID=VSP_034214;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18204447;Dbxref=PMID:18204447
BANK1	Q8NDB2	23	156	61	61	Natural variant	ID=VAR_027729;Note=Polymorphism%3B may influence susceptibility to SLE. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18204447;Dbxref=dbSNP:rs10516487,PMID:18204447
BANK1	Q8NDB2	23	156	143	143	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANK1	Q8NDB2	531	633	557	557	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANP	Q8N9N5	113	151	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	210	290	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	290	346	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	426	448	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	113	151	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	210	290	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	290	346	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	426	448	1	519	Chain	ID=PRO_0000297910;Note=Protein BANP
BANP	Q8N9N5	210	290	226	322	Domain	Note=BEN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00784
BANP	Q8N9N5	290	346	226	322	Domain	Note=BEN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00784
BANP	Q8N9N5	210	290	226	322	Domain	Note=BEN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00784
BANP	Q8N9N5	290	346	226	322	Domain	Note=BEN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00784
BANP	Q8N9N5	210	290	152	342	Region	Note=Interaction with CUX1 and HDAC1;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	290	346	152	342	Region	Note=Interaction with CUX1 and HDAC1;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	210	290	152	342	Region	Note=Interaction with CUX1 and HDAC1;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	290	346	152	342	Region	Note=Interaction with CUX1 and HDAC1;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	290	346	320	349	Region	Note=Necessary and sufficient for TP53 activation;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	290	346	320	349	Region	Note=Necessary and sufficient for TP53 activation;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	290	346	342	393	Region	Note=DNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	290	346	342	393	Region	Note=DNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
BANP	Q8N9N5	426	448	361	426	Compositional bias	Note=Gln-rich
BANP	Q8N9N5	426	448	361	426	Compositional bias	Note=Gln-rich
BANP	Q8N9N5	210	290	275	275	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VBU8
BANP	Q8N9N5	210	290	275	275	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VBU8
BANP	Q8N9N5	113	151	133	133	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BANP	Q8N9N5	113	151	133	133	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BANP	Q8N9N5	113	151	114	152	Alternative sequence	ID=VSP_027400;Note=In isoform 2%2C isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
BANP	Q8N9N5	113	151	114	152	Alternative sequence	ID=VSP_027400;Note=In isoform 2%2C isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
BANP	Q8N9N5	426	448	425	446	Alternative sequence	ID=VSP_027402;Note=In isoform 2%2C isoform 3%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
BANP	Q8N9N5	426	448	425	446	Alternative sequence	ID=VSP_027402;Note=In isoform 2%2C isoform 3%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
BANP	Q8N9N5	113	151	123	123	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANP	Q8N9N5	113	151	123	123	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANP	Q8N9N5	290	346	338	338	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANP	Q8N9N5	290	346	338	338	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BBS1	Q8NFJ9	53	144	2	593	Chain	ID=PRO_0000064841;Note=Bardet-Biedl syndrome 1 protein
BBS1	Q8NFJ9	53	144	53	53	Natural variant	ID=VAR_038881;Note=In BBS1. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12677556;Dbxref=dbSNP:rs766602837,PMID:12677556
BCAT1	P54687	301	348	1	386	Chain	ID=PRO_0000103292;Note=Branched-chain-amino-acid aminotransferase%2C cytosolic
BCAT1	P54687	93	130	1	386	Chain	ID=PRO_0000103292;Note=Branched-chain-amino-acid aminotransferase%2C cytosolic
BCAT1	P54687	26	93	1	386	Chain	ID=PRO_0000103292;Note=Branched-chain-amino-acid aminotransferase%2C cytosolic
BCAT1	P54687	93	130	94	130	Alternative sequence	ID=VSP_042652;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BCAT1	P54687	26	93	59	59	Natural variant	ID=VAR_047681;Note=T->M;Dbxref=dbSNP:rs17374285
BCAT1	P54687	301	348	321	321	Natural variant	ID=VAR_019614;Note=E->K;Dbxref=dbSNP:rs7313020
BCAT1	P54687	301	348	330	330	Natural variant	ID=VAR_047682;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8692959;Dbxref=dbSNP:rs1057204,PMID:8692959
BCAT1	P54687	301	348	317	317	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAT1	P54687	26	93	27	29	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	26	93	44	46	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ABJ
BCAT1	P54687	26	93	49	51	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COG
BCAT1	P54687	26	93	55	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	26	93	64	66	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	26	93	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	26	93	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	26	93	86	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	93	130	93	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	26	93	93	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	93	130	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	93	130	108	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	93	130	113	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	289	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	303	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	313	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	321	323	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	325	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	333	335	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BCAT1	P54687	301	348	336	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2COI
BLVRA	P53004	117	153	3	296	Chain	ID=PRO_0000010853;Note=Biliverdin reductase A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8631357;Dbxref=PMID:8631357
BLVRA	P53004	117	153	3	296	Chain	ID=PRO_0000010853;Note=Biliverdin reductase A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8631357;Dbxref=PMID:8631357
BLVRA	P53004	117	153	121	121	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BLVRA	P53004	117	153	121	121	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BLVRA	P53004	117	153	104	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	104	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	121	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	121	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	126	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	126	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	131	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	131	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	145	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BLVRA	P53004	117	153	145	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H63
BICC1	Q9H694	182	200	1	974	Chain	ID=PRO_0000267714;Note=Protein bicaudal C homolog 1
BICC1	Q9H694	200	265	1	974	Chain	ID=PRO_0000267714;Note=Protein bicaudal C homolog 1
BICC1	Q9H694	182	200	132	199	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
ARFGEF1	Q9Y6D6	104	153	1	1849	Chain	ID=PRO_0000120207;Note=Brefeldin A-inhibited guanine nucleotide-exchange protein 1
ARFGEF1	Q9Y6D6	104	153	2	224	Region	Note=DCB%3B DCB:DCB domain and DCB:HUS domain interaction
ARFGEF1	Q9Y6D6	104	153	93	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EE5
ARFGEF1	Q9Y6D6	104	153	122	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5C
ARFGEF1	Q9Y6D6	104	153	126	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EE5
ARFGEF1	Q9Y6D6	104	153	145	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EE5
ADAMTS8	Q9UP79	365	421	214	889	Chain	ID=PRO_0000029179;Note=A disintegrin and metalloproteinase with thrombospondin motifs 8
ADAMTS8	Q9UP79	240	320	214	889	Chain	ID=PRO_0000029179;Note=A disintegrin and metalloproteinase with thrombospondin motifs 8
ADAMTS8	Q9UP79	365	421	219	429	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAMTS8	Q9UP79	240	320	219	429	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAMTS8	Q9UP79	365	421	367	367	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS8	Q9UP79	365	421	373	373	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS8	Q9UP79	365	421	400	400	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTS8	Q9UP79	240	320	294	347	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS8	Q9UP79	365	421	341	424	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS8	Q9UP79	365	421	379	408	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS8	Q9UP79	365	421	412	439	Sequence conflict	Note=YLTELLDGGHGDCLLDAPAAALPLPTGL->FSGCHLQGWIHFKYLCKCVSELKCDLMP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATR	Q13535	2299	2347	1	2644	Chain	ID=PRO_0000088844;Note=Serine/threonine-protein kinase ATR
ATR	Q13535	2229	2299	1	2644	Chain	ID=PRO_0000088844;Note=Serine/threonine-protein kinase ATR
ATR	Q13535	1853	1912	1	2644	Chain	ID=PRO_0000088844;Note=Serine/threonine-protein kinase ATR
ATR	Q13535	1677	1732	1	2644	Chain	ID=PRO_0000088844;Note=Serine/threonine-protein kinase ATR
ATR	Q13535	1315	1384	1	2644	Chain	ID=PRO_0000088844;Note=Serine/threonine-protein kinase ATR
ATR	Q13535	450	513	1	2644	Chain	ID=PRO_0000088844;Note=Serine/threonine-protein kinase ATR
ATR	Q13535	1315	1384	1329	1365	Repeat	Note=HEAT 2
ATR	Q13535	1853	1912	1640	2185	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
ATR	Q13535	1677	1732	1640	2185	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
ATR	Q13535	2299	2347	2322	2567	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
ATR	Q13535	450	513	450	450	Alternative sequence	ID=VSP_013305;Note=In isoform 2. E->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11470508;Dbxref=PMID:11470508
ATR	Q13535	450	513	451	514	Alternative sequence	ID=VSP_013304;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11470508;Dbxref=PMID:11470508
ATR	Q13535	2229	2299	2233	2233	Natural variant	ID=VAR_041597;Note=In a lung large cell carcinoma sample%3B somatic mutation. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
ATR	Q13535	2299	2347	2327	2327	Mutagenesis	Note=Abolishes kinase activity. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11114888,ECO:0000269|PubMed:12011431,ECO:0000269|PubMed:9925639;Dbxref=PMID:11114888,PMID:12011431,PMID:9925639
ADAMTS13	Q76LX8	110	138	75	1427	Chain	ID=PRO_0000247511;Note=A disintegrin and metalloproteinase with thrombospondin motifs 13
ADAMTS13	Q76LX8	745	806	75	1427	Chain	ID=PRO_0000247511;Note=A disintegrin and metalloproteinase with thrombospondin motifs 13
ADAMTS13	Q76LX8	110	138	80	286	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAMTS13	Q76LX8	745	806	742	805	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTS13	Q76LX8	745	806	757	757	Glycosylation	Note=O-linked (Fuc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17395589;Dbxref=PMID:17395589
ADAMTS13	Q76LX8	110	138	2	329	Alternative sequence	ID=VSP_055537;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
ADAMTS13	Q76LX8	745	806	693	1427	Alternative sequence	ID=VSP_055539;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
ADAMTS13	Q76LX8	110	138	119	119	Natural variant	ID=VAR_067771;Note=In TTP. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18443791;Dbxref=dbSNP:rs281875291,PMID:18443791
ADAMTS13	Q76LX8	745	806	758	758	Natural variant	ID=VAR_067789;Note=In TTP. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15009458;Dbxref=dbSNP:rs281875300,PMID:15009458
ADAMTS13	Q76LX8	745	806	757	757	Mutagenesis	Note=No effect on cleavage of VWF and little change in secretion of ADAMTS13. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17395589;Dbxref=PMID:17395589
AXIN1	O15169	729	764	1	862	Chain	ID=PRO_0000220888;Note=Axin-1
AXIN1	O15169	595	651	1	862	Chain	ID=PRO_0000220888;Note=Axin-1
AXIN1	O15169	372	418	1	862	Chain	ID=PRO_0000220888;Note=Axin-1
AXIN1	O15169	293	339	1	862	Chain	ID=PRO_0000220888;Note=Axin-1
AXIN1	O15169	293	339	209	338	Region	Note=Interaction with TP53;Ontology_term=ECO:0000250;evidence=ECO:0000250
AXIN1	O15169	372	418	348	433	Region	Note=Interaction with GSK3B;Ontology_term=ECO:0000250;evidence=ECO:0000250
AXIN1	O15169	729	764	507	757	Region	Note=Interaction with RNF111;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16601693;Dbxref=PMID:16601693
AXIN1	O15169	595	651	507	757	Region	Note=Interaction with RNF111;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16601693;Dbxref=PMID:16601693
AXIN1	O15169	729	764	575	789	Region	Note=Interaction with PPP2CA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9920888;Dbxref=PMID:9920888
AXIN1	O15169	595	651	575	789	Region	Note=Interaction with PPP2CA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9920888;Dbxref=PMID:9920888
AXIN1	O15169	729	764	677	752	Region	Note=Interaction with HIPK2;Ontology_term=ECO:0000250;evidence=ECO:0000250
AXIN1	O15169	729	764	730	765	Alternative sequence	ID=VSP_019398;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AXIN1	O15169	595	651	650	650	Natural variant	ID=VAR_015592;Note=In HCC%3B also found in hepatoblastoma. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12101426;Dbxref=dbSNP:rs117208012,PMID:12101426
AXIN1	O15169	372	418	379	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WZZ
AXIN1	O15169	372	418	385	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NM3
SLC4A2	P04920	658	730	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	780	845	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	845	930	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	930	960	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	1157	1215	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	658	730	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	780	845	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	845	930	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	930	960	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	1157	1215	1	1241	Chain	ID=PRO_0000079215;Note=Anion exchange protein 2
SLC4A2	P04920	658	730	1	707	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	658	730	1	707	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	658	730	708	731	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	658	730	708	731	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	780	845	784	816	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	780	845	784	816	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	780	845	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	780	845	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	848	900	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	848	900	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	901	918	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	901	918	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	919	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	930	960	919	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	919	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	930	960	919	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	930	960	934	954	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	930	960	934	954	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	1157	1215	1163	1199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	1157	1215	1163	1199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	658	730	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	780	845	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	845	930	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	930	960	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	1157	1215	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	658	730	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	780	845	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	845	930	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	930	960	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	1157	1215	708	1241	Region	Note=Membrane (anion exchange)
SLC4A2	P04920	1157	1215	1173	1173	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC4A2	P04920	1157	1215	1173	1173	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC4A2	P04920	845	930	859	859	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	859	859	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	868	868	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	868	868	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	882	882	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	845	930	882	882	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A2	P04920	1157	1215	1204	1204	Natural variant	ID=VAR_025171;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34918764
SLC4A2	P04920	1157	1215	1204	1204	Natural variant	ID=VAR_025171;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs34918764
SLC4A2	P04920	658	730	666	681	Sequence conflict	Note=AAGAAEDDPLRRTGRP->RQGQLKMIPSADGAA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	658	730	666	681	Sequence conflict	Note=AAGAAEDDPLRRTGRP->RQGQLKMIPSADGAA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	658	730	666	681	Sequence conflict	Note=AAGAAEDDPLRRTGRP->RQGQLKMIPSADGAA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	658	730	666	681	Sequence conflict	Note=AAGAAEDDPLRRTGRP->RQGQLKMIPSADGAA;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	780	845	824	824	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	780	845	824	824	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	780	845	824	824	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	780	845	824	824	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	845	930	902	902	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	845	930	902	902	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	845	930	902	902	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A2	P04920	845	930	902	902	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	657	730	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	780	845	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	922	952	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	1149	1207	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	657	730	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	780	845	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	922	952	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	1149	1207	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	657	730	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	780	845	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	922	952	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	1149	1207	1	1232	Chain	ID=PRO_0000079219;Note=Anion exchange protein 3
SLC4A3	P48751	657	730	1	708	Topological domain	Note=Cytoplasmic
SLC4A3	P48751	657	730	1	708	Topological domain	Note=Cytoplasmic
SLC4A3	P48751	657	730	1	708	Topological domain	Note=Cytoplasmic
SLC4A3	P48751	657	730	709	731	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	657	730	709	731	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	657	730	709	731	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	780	845	794	816	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	780	845	794	816	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	780	845	794	816	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	780	845	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	780	845	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	780	845	826	847	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	922	952	911	925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	922	952	911	925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	922	952	911	925	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	922	952	926	946	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	922	952	926	946	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	922	952	926	946	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	1149	1207	1155	1191	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	1149	1207	1155	1191	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	1149	1207	1155	1191	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC4A3	P48751	657	730	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	780	845	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	922	952	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	1149	1207	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	657	730	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	780	845	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	922	952	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	1149	1207	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	657	730	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	780	845	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	922	952	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	1149	1207	709	1232	Region	Note=Membrane (anion exchange)
SLC4A3	P48751	1149	1207	1184	1187	Compositional bias	Note=Poly-Leu
SLC4A3	P48751	1149	1207	1184	1187	Compositional bias	Note=Poly-Leu
SLC4A3	P48751	1149	1207	1184	1187	Compositional bias	Note=Poly-Leu
SLC4A3	P48751	1149	1207	1165	1165	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC4A3	P48751	1149	1207	1165	1165	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC4A3	P48751	1149	1207	1165	1165	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC4A3	P48751	657	730	702	702	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	657	730	702	702	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	657	730	702	702	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	780	845	812	813	Sequence conflict	Note=GS->FI;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	780	845	812	813	Sequence conflict	Note=GS->FI;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	780	845	812	813	Sequence conflict	Note=GS->FI;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	780	845	822	822	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	780	845	822	822	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A3	P48751	780	845	822	822	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC4A1	P02730	600	630	1	911	Chain	ID=PRO_0000079209;Note=Band 3 anion transport protein
SLC4A1	P02730	600	630	592	602	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26542571;Dbxref=PMID:26542571
SLC4A1	P02730	600	630	603	623	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26542571;Dbxref=PMID:26542571
SLC4A1	P02730	600	630	624	663	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26542571;Dbxref=PMID:26542571
SLC4A1	P02730	600	630	559	630	Region	Note=Involved in anion transport
SLC4A1	P02730	600	630	602	602	Natural variant	ID=VAR_039292;Note=In dRTA-HA. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15211439;Dbxref=dbSNP:rs121912754,PMID:15211439
SLC4A1	P02730	600	630	609	609	Natural variant	ID=VAR_058041;Note=In AD-dRTA%3B detected subapically and at the apical membrane as well as at the basolateral membrane in contrast to the normal basolateral appearance of wild-type protein. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14734552;Dbxref=dbSNP:rs878853002,PMID:14734552
SLC4A1	P02730	600	630	613	613	Natural variant	ID=VAR_015107;Note=In AD-dRTA%3B markedly increased red cell sulfate transport but almost normal red cell iodide transport. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9312167;Dbxref=dbSNP:rs121912746,PMID:9312167
SLC4A1	P02730	600	630	599	607	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZF
SLC4A1	P02730	600	630	609	623	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZF
B9D1	Q9UPM9	21	44	1	204	Chain	ID=PRO_0000307667;Note=B9 domain-containing protein 1
B9D1	Q9UPM9	21	44	9	127	Domain	Note=B9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00713
B9D1	Q9UPM9	21	44	32	32	Natural variant	ID=VAR_076974;Note=In JBTS27. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24886560;Dbxref=dbSNP:rs771170000,PMID:24886560
BCAR3	O75815	119	162	2	825	Chain	ID=PRO_0000230284;Note=Breast cancer anti-estrogen resistance protein 3
BCAR3	O75815	119	162	2	825	Chain	ID=PRO_0000230284;Note=Breast cancer anti-estrogen resistance protein 3
BCAR3	O75815	119	162	2	825	Chain	ID=PRO_0000230284;Note=Breast cancer anti-estrogen resistance protein 3
BCAR3	O75815	119	162	154	253	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
BCAR3	O75815	119	162	154	253	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
BCAR3	O75815	119	162	154	253	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
BCAR3	O75815	119	162	1	324	Alternative sequence	ID=VSP_017814;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
BCAR3	O75815	119	162	1	324	Alternative sequence	ID=VSP_017814;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
BCAR3	O75815	119	162	1	324	Alternative sequence	ID=VSP_017814;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
BCR	P11274	487	522	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	584	620	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	658	705	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	802	842	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	902	927	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	960	1004	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	1004	1024	1	1271	Chain	ID=PRO_0000080933;Note=Breakpoint cluster region protein
BCR	P11274	487	522	498	691	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
BCR	P11274	584	620	498	691	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
BCR	P11274	658	705	498	691	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
BCR	P11274	802	842	708	866	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
BCR	P11274	902	927	870	1002	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
BCR	P11274	960	1004	870	1002	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
BCR	P11274	802	842	824	827	Compositional bias	Note=Poly-Leu
BCR	P11274	487	522	488	488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BCR	P11274	658	705	693	693	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BCR	P11274	960	1004	961	1004	Alternative sequence	ID=VSP_024352;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3285291;Dbxref=PMID:3285291
BCR	P11274	1004	1024	961	1004	Alternative sequence	ID=VSP_024352;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:3285291;Dbxref=PMID:3285291
BCR	P11274	902	927	910	910	Natural variant	ID=VAR_041886;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35537221,PMID:17344846
BCR	P11274	658	705	690	690	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCR	P11274	487	522	492	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N7E
BCR	P11274	584	620	578	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N7E
BCR	P11274	584	620	588	611	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N7E
BCR	P11274	584	620	613	618	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N7E
BCR	P11274	658	705	653	661	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N7E
BCR	P11274	658	705	670	687	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N7E
BCR	P11274	658	705	694	697	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5N6R
BCR	P11274	802	842	830	838	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OC7
BSG	P35613	22	138	22	385	Chain	ID=PRO_0000014518;Note=Basigin
BSG	P35613	22	138	138	323	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BSG	P35613	22	138	138	219	Domain	Note=Ig-like C2-type
BSG	P35613	22	138	1	209	Alternative sequence	ID=VSP_043225;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21536654;Dbxref=PMID:21536654
BSG	P35613	22	138	12	191	Alternative sequence	ID=VSP_043227;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21536654;Dbxref=PMID:21536654
BSG	P35613	22	138	24	139	Alternative sequence	ID=VSP_011501;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1634773,ECO:0000303|PubMed:7812975;Dbxref=PMID:15489334,PMID:1634773,PMID:7812975
BSG	P35613	22	138	24	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	32	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	40	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	53	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	74	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	79	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	104	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	116	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BSG	P35613	22	138	128	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3QR2
BBS5	Q8N3I7	206	227	1	341	Chain	ID=PRO_0000223254;Note=Bardet-Biedl syndrome 5 protein
BBS5	Q8N3I7	206	227	207	227	Alternative sequence	ID=VSP_017240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15137946;Dbxref=PMID:15137946
BBS5	Q8N3I7	206	227	207	207	Natural variant	ID=VAR_025317;Note=Found as heterozygous variant in patients with Bardet-Biedl syndrome%3B might have a modifying effect on disease phenotype. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15137946;Dbxref=dbSNP:rs35487251,PMID:15137946
BBX	Q8WY36	734	764	1	941	Chain	ID=PRO_0000232885;Note=HMG box transcription factor BBX
BBX	Q8WY36	734	764	671	773	Compositional bias	Note=Lys-rich
BBX	Q8WY36	734	764	629	941	Alternative sequence	ID=VSP_054881;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BBX	Q8WY36	734	764	735	764	Alternative sequence	ID=VSP_018006;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.2;Dbxref=PMID:11230166
BCAT2	O15382	8	33	1	27	Transit peptide	Note=Mitochondrion
BCAT2	O15382	355	380	28	392	Chain	ID=PRO_0000001271;Note=Branched-chain-amino-acid aminotransferase%2C mitochondrial
BCAT2	O15382	308	355	28	392	Chain	ID=PRO_0000001271;Note=Branched-chain-amino-acid aminotransferase%2C mitochondrial
BCAT2	O15382	33	100	28	392	Chain	ID=PRO_0000001271;Note=Branched-chain-amino-acid aminotransferase%2C mitochondrial
BCAT2	O15382	8	33	28	392	Chain	ID=PRO_0000001271;Note=Branched-chain-amino-acid aminotransferase%2C mitochondrial
BCAT2	O15382	308	355	321	321	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
BCAT2	O15382	33	100	9	100	Alternative sequence	ID=VSP_000236;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11170829;Dbxref=PMID:11170829
BCAT2	O15382	8	33	9	100	Alternative sequence	ID=VSP_000236;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11170829;Dbxref=PMID:11170829
BCAT2	O15382	308	355	342	342	Mutagenesis	Note=Reduces activity about 6-fold. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17050531;Dbxref=PMID:17050531
BCAT2	O15382	308	355	345	345	Mutagenesis	Note=Slight reduction of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17050531;Dbxref=PMID:17050531
BCAT2	O15382	308	355	326	326	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAT2	O15382	308	355	330	330	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAT2	O15382	308	355	349	349	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAT2	O15382	355	380	357	357	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAT2	O15382	355	380	370	370	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCAT2	O15382	33	100	34	36	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	33	100	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HG8
BCAT2	O15382	33	100	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	33	100	63	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	33	100	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EKF
BCAT2	O15382	33	100	79	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	33	100	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CR5
BCAT2	O15382	33	100	93	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	33	100	100	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	296	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	310	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	320	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	332	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	340	342	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	343	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	355	380	355	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	308	355	355	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	355	380	361	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCAT2	O15382	355	380	367	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MPR
BCL11B	Q9C0K0	142	213	1	894	Chain	ID=PRO_0000047104;Note=B-cell lymphoma/leukemia 11B
BCL11B	Q9C0K0	142	213	143	213	Alternative sequence	ID=VSP_009565;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11719382;Dbxref=PMID:11719382
BCLAF1	Q9NYF8	799	848	1	920	Chain	ID=PRO_0000064888;Note=Bcl-2-associated transcription factor 1
BCLAF1	Q9NYF8	799	848	803	803	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
BCLAF1	Q9NYF8	799	848	809	809	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
BCLAF1	Q9NYF8	799	848	831	831	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
BCLAF1	Q9NYF8	799	848	831	831	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25772364,PMID:28112733
BCLAF1	Q9NYF8	799	848	800	848	Alternative sequence	ID=VSP_010370;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10330179;Dbxref=PMID:10330179
BCORL1	Q5H9F3	1229	1359	1	1711	Chain	ID=PRO_0000312268;Note=BCL-6 corepressor-like protein 1
BCORL1	Q5H9F3	1229	1359	1	1711	Chain	ID=PRO_0000312268;Note=BCL-6 corepressor-like protein 1
BCORL1	Q5H9F3	1229	1359	1328	1336	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
BCORL1	Q5H9F3	1229	1359	1328	1336	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
BCORL1	Q5H9F3	1229	1359	1230	1359	Alternative sequence	ID=VSP_029778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
BCORL1	Q5H9F3	1229	1359	1230	1359	Alternative sequence	ID=VSP_029778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
BCL3	P20749	297	353	1	454	Chain	ID=PRO_0000066976;Note=B-cell lymphoma 3 protein
BCL3	P20749	297	353	275	304	Repeat	Note=ANK 5
BCL3	P20749	297	353	308	337	Repeat	Note=ANK 6
BCL3	P20749	297	353	338	367	Repeat	Note=ANK 7
BCL3	P20749	297	353	289	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	312	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	322	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	345	348	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	352	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL6	P41182	613	659	1	706	Chain	ID=PRO_0000047098;Note=B-cell lymphoma 6 protein
BCL6	P41182	513	569	1	706	Chain	ID=PRO_0000047098;Note=B-cell lymphoma 6 protein
BCL6	P41182	613	659	1	706	Chain	ID=PRO_0000047098;Note=B-cell lymphoma 6 protein
BCL6	P41182	513	569	1	706	Chain	ID=PRO_0000047098;Note=B-cell lymphoma 6 protein
BCL6	P41182	513	569	518	541	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	513	569	518	541	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	513	569	546	568	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	513	569	546	568	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	613	659	602	624	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	613	659	602	624	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	613	659	630	652	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	613	659	630	652	Zinc finger	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	613	659	658	681	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	613	659	658	681	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
BCL6	P41182	513	569	514	569	Alternative sequence	ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
BCL6	P41182	513	569	514	569	Alternative sequence	ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
BCL6	P41182	513	569	520	523	Mutagenesis	Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096
BCL6	P41182	513	569	520	523	Mutagenesis	Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096
BCL6	P41182	513	569	548	551	Mutagenesis	Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096
BCL6	P41182	513	569	548	551	Mutagenesis	Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096
BCL6	P41182	613	659	632	635	Mutagenesis	Note=Abolishes DNA-binding and transcriptional repression activity%2C no effect on nuclear localization and interaction with HDAC5. CEIC->GEIG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096
BCL6	P41182	613	659	632	635	Mutagenesis	Note=Abolishes DNA-binding and transcriptional repression activity%2C no effect on nuclear localization and interaction with HDAC5. CEIC->GEIG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096
BCL6	P41182	513	569	521	523	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM
BCL6	P41182	513	569	521	523	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM
BCL6	P41182	513	569	527	529	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM
BCL6	P41182	513	569	527	529	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM
BCL6	P41182	513	569	530	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM
BCL6	P41182	513	569	530	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM
BCL6	P41182	513	569	558	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE
BCL6	P41182	513	569	558	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE
BCL6	P41182	613	659	610	613	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EN2
BCL6	P41182	613	659	610	613	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EN2
BCL6	P41182	613	659	614	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EN2
BCL6	P41182	613	659	614	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EN2
BCL6	P41182	613	659	622	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EN2
BCL6	P41182	613	659	622	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EN2
BCL6	P41182	613	659	633	635	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	633	635	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	639	641	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	639	641	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	642	648	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	642	648	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	649	652	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BCL6	P41182	613	659	649	652	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EOS
BEST3	Q8N1M1	238	289	1	668	Chain	ID=PRO_0000143121;Note=Bestrophin-3
BEST3	Q8N1M1	82	160	1	668	Chain	ID=PRO_0000143121;Note=Bestrophin-3
BEST3	Q8N1M1	82	160	71	91	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST3	Q8N1M1	82	160	92	178	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST3	Q8N1M1	238	289	229	249	Intramembrane	Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST3	Q8N1M1	238	289	250	270	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST3	Q8N1M1	238	289	271	291	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BEST3	Q8N1M1	82	160	1	162	Alternative sequence	ID=VSP_046979;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BEST3	Q8N1M1	82	160	1	106	Alternative sequence	ID=VSP_008981;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BEST3	Q8N1M1	238	289	179	668	Alternative sequence	ID=VSP_008983;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BEST3	Q8N1M1	238	289	239	289	Alternative sequence	ID=VSP_046980;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BICD2	Q8TD16	80	151	2	824	Chain	ID=PRO_0000205359;Note=Protein bicaudal D homolog 2
BICD2	Q8TD16	80	151	25	398	Region	Note=Interacts with DYNLL1%2C DYNC1H1%2C DYNC1I2%2C DCTN1 and DCTN2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q921C5
BICD2	Q8TD16	80	151	20	269	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BICD2	Q8TD16	80	151	90	90	Natural variant	ID=VAR_070111;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23664116;Dbxref=dbSNP:rs61754130,PMID:23664116
BICD2	Q8TD16	80	151	107	107	Natural variant	ID=VAR_070112;Note=In SMALED2%3B causes Golgi fragmentation%3B affects interaction with RAB6A and DNAI1 and the subcellular location of the protein. S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23664116,ECO:0000269|PubMed:23664119,ECO:0000269|PubMed:23664120;Dbxref=dbSNP:rs398123028,PMID:23664116,PMID:23664119,PMID:23664120
ADAMTS7	Q9UKP4	489	520	237	1686	Chain	ID=PRO_0000029177;Note=A disintegrin and metalloproteinase with thrombospondin motifs 7
ADAMTS7	Q9UKP4	489	520	462	537	Domain	Note=Disintegrin
ADAMTS7	Q9UKP4	489	520	474	497	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS7	Q9UKP4	489	520	485	503	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS7	Q9UKP4	489	520	492	522	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS7	Q9UKP4	489	520	516	527	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS12	P58397	1324	1375	241	1594	Chain	ID=PRO_0000029187;Note=A disintegrin and metalloproteinase with thrombospondin motifs 12
ADAMTS12	P58397	347	396	241	1594	Chain	ID=PRO_0000029187;Note=A disintegrin and metalloproteinase with thrombospondin motifs 12
ADAMTS12	P58397	347	396	246	456	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAMTS12	P58397	1324	1375	1313	1366	Domain	Note=TSP type-1 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTS12	P58397	1324	1375	1368	1422	Domain	Note=TSP type-1 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTS12	P58397	347	396	393	393	Active site	Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276,ECO:0000255|PROSITE-ProRule:PRU10095
ADAMTS12	P58397	347	396	392	392	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS12	P58397	347	396	396	396	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS12	P58397	1324	1375	1372	1372	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTS12	P58397	347	396	322	376	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS12	P58397	347	396	351	358	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS12	P58397	347	396	370	451	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS12	P58397	1324	1375	230	1594	Alternative sequence	ID=VSP_013142;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ADAMTS12	P58397	347	396	230	1594	Alternative sequence	ID=VSP_013142;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ADAMTS12	P58397	1324	1375	1336	1336	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADAMTS12	P58397	1324	1375	1341	1341	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADAMTS1	Q9UHI8	403	459	253	967	Chain	ID=PRO_0000029151;Note=A disintegrin and metalloproteinase with thrombospondin motifs 1
ADAMTS1	Q9UHI8	403	459	258	467	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAMTS1	Q9UHI8	403	459	405	405	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897672;Dbxref=PMID:17897672
ADAMTS1	Q9UHI8	403	459	411	411	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897672;Dbxref=PMID:17897672
ADAMTS1	Q9UHI8	403	459	379	462	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897672;Dbxref=PMID:17897672
ADAMTS1	Q9UHI8	403	459	417	446	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897672;Dbxref=PMID:17897672
ADAMTS1	Q9UHI8	403	459	395	406	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4B
ADAMTS1	Q9UHI8	403	459	415	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4B
ADAMTS1	Q9UHI8	403	459	418	420	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4B
ADAMTS1	Q9UHI8	403	459	445	456	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4B
ADAMTS1	Q9UHI8	403	459	457	460	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V4B
B4GALNT4	Q76KP1	116	148	1	1039	Chain	ID=PRO_0000252370;Note=N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
B4GALNT4	Q76KP1	116	148	37	1039	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALNT4	Q76KP1	116	148	108	278	Domain	Note=PA14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01164
BAALC	Q8WXS3	53	88	2	180	Chain	ID=PRO_0000248205;Note=Brain and acute leukemia cytoplasmic protein
BAALC	Q8WXS3	53	88	54	88	Alternative sequence	ID=VSP_020196;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11707601,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11707601,PMID:14702039,PMID:15489334
BAALC	Q8WXS3	53	88	54	80	Alternative sequence	ID=VSP_020199;Note=In isoform 4. VLEAEKSKIKAPTDSVSDEGLFSASKM->AHYPLAFALAWRDNSLGALLVQEGLCR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707601;Dbxref=PMID:11707601
BAALC	Q8WXS3	53	88	54	73	Alternative sequence	ID=VSP_020201;Note=In isoform 5. VLEAEKSKIKAPTDSVSDEG->GCLEEHYHLTALQKVGHPNH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707601;Dbxref=PMID:11707601
BAALC	Q8WXS3	53	88	54	54	Alternative sequence	ID=VSP_020203;Note=In isoform 6. V->G;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11707601,ECO:0000303|PubMed:15489334;Dbxref=PMID:11707601,PMID:15489334
BAALC	Q8WXS3	53	88	55	180	Alternative sequence	ID=VSP_020204;Note=In isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11707601,ECO:0000303|PubMed:15489334;Dbxref=PMID:11707601,PMID:15489334
BAALC	Q8WXS3	53	88	74	180	Alternative sequence	ID=VSP_020202;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707601;Dbxref=PMID:11707601
BAALC	Q8WXS3	53	88	81	180	Alternative sequence	ID=VSP_020200;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11707601;Dbxref=PMID:11707601
KCTD10	Q9H3F6	129	158	1	313	Chain	ID=PRO_0000247421;Note=BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
KCTD10	Q9H3F6	129	158	1	158	Alternative sequence	ID=VSP_019978;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
B4GALT4	O60513	225	265	1	344	Chain	ID=PRO_0000080542;Note=Beta-1%2C4-galactosyltransferase 4
B4GALT4	O60513	225	265	1	344	Chain	ID=PRO_0000080542;Note=Beta-1%2C4-galactosyltransferase 4
B4GALT4	O60513	225	265	1	344	Chain	ID=PRO_0000080542;Note=Beta-1%2C4-galactosyltransferase 4
B4GALT4	O60513	225	265	39	344	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT4	O60513	225	265	39	344	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT4	O60513	225	265	39	344	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT4	O60513	225	265	258	261	Region	Note=N-acetyl-D-glucosamine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT4	O60513	225	265	258	261	Region	Note=N-acetyl-D-glucosamine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT4	O60513	225	265	258	261	Region	Note=N-acetyl-D-glucosamine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT4	O60513	225	265	256	256	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT4	O60513	225	265	256	256	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT4	O60513	225	265	256	256	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000250;evidence=ECO:0000250
BACE2	Q9Y5Z0	249	294	63	518	Chain	ID=PRO_0000025946;Note=Beta-secretase 2
BACE2	Q9Y5Z0	328	378	63	518	Chain	ID=PRO_0000025946;Note=Beta-secretase 2
BACE2	Q9Y5Z0	249	294	21	473	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BACE2	Q9Y5Z0	328	378	21	473	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BACE2	Q9Y5Z0	249	294	92	429	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
BACE2	Q9Y5Z0	328	378	92	429	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
BACE2	Q9Y5Z0	328	378	366	366	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BACE2	Q9Y5Z0	249	294	233	433	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16305800;Dbxref=PMID:16305800
BACE2	Q9Y5Z0	328	378	233	433	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16305800;Dbxref=PMID:16305800
BACE2	Q9Y5Z0	249	294	292	457	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16305800;Dbxref=PMID:16305800
BACE2	Q9Y5Z0	328	378	292	457	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16305800;Dbxref=PMID:16305800
BACE2	Q9Y5Z0	328	378	344	393	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16305800;Dbxref=PMID:16305800
BACE2	Q9Y5Z0	328	378	329	378	Alternative sequence	ID=VSP_038025;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10965118;Dbxref=PMID:10965118
BACE2	Q9Y5Z0	249	294	247	253	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	249	294	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	249	294	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	249	294	271	274	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	249	294	278	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	249	294	292	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	328	378	327	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKS
BACE2	Q9Y5Z0	328	378	334	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	328	378	339	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKN
BACE2	Q9Y5Z0	328	378	343	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	328	378	347	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BFB
BACE2	Q9Y5Z0	328	378	352	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	328	378	358	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	328	378	369	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACE2	Q9Y5Z0	328	378	377	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZKQ
BACH1	O14867	78	523	1	736	Chain	ID=PRO_0000076454;Note=Transcription regulator protein BACH1
BACH1	O14867	78	523	1	736	Chain	ID=PRO_0000076454;Note=Transcription regulator protein BACH1
BACH1	O14867	78	523	34	100	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
BACH1	O14867	78	523	34	100	Domain	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
BACH1	O14867	78	523	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BACH1	O14867	78	523	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BACH1	O14867	78	523	364	364	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BACH1	O14867	78	523	364	364	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BACH1	O14867	78	523	445	445	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
BACH1	O14867	78	523	445	445	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
BACH1	O14867	78	523	314	314	Natural variant	ID=VAR_048441;Note=S->P;Dbxref=dbSNP:rs35474725
BACH1	O14867	78	523	314	314	Natural variant	ID=VAR_048441;Note=S->P;Dbxref=dbSNP:rs35474725
BACH1	O14867	78	523	158	158	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
BACH1	O14867	78	523	158	158	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
BACH1	O14867	78	523	171	171	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BACH1	O14867	78	523	171	171	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BACH1	O14867	78	523	81	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	81	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	94	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	94	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	100	102	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	100	102	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	103	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	103	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	120	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
BACH1	O14867	78	523	120	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IHC
KCTD13	Q8WZ19	138	168	1	329	Chain	ID=PRO_0000191297;Note=BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
KCTD13	Q8WZ19	138	168	127	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UIJ
BAZ2B	Q9UIF8	2070	2117	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	966	988	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	944	966	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	788	822	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	633	731	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	111	167	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	48	111	1	2168	Chain	ID=PRO_0000211174;Note=Bromodomain adjacent to zinc finger domain protein 2B
BAZ2B	Q9UIF8	788	822	739	810	Domain	Note=MBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00338
BAZ2B	Q9UIF8	2070	2117	2077	2147	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
BAZ2B	Q9UIF8	966	988	883	1061	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BAZ2B	Q9UIF8	944	966	883	1061	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
BAZ2B	Q9UIF8	111	167	149	265	Compositional bias	Note=Ser-rich
BAZ2B	Q9UIF8	633	731	595	666	Compositional bias	Note=Asp/Glu-rich (acidic)
BAZ2B	Q9UIF8	966	988	902	1061	Compositional bias	Note=Lys-rich
BAZ2B	Q9UIF8	944	966	902	1061	Compositional bias	Note=Lys-rich
BAZ2B	Q9UIF8	111	167	1	196	Alternative sequence	ID=VSP_037114;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662543;Dbxref=PMID:10662543
BAZ2B	Q9UIF8	48	111	1	196	Alternative sequence	ID=VSP_037114;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10662543;Dbxref=PMID:10662543
BAZ2B	Q9UIF8	111	167	112	113	Alternative sequence	ID=VSP_037115;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10819331,ECO:0000303|PubMed:15489334;Dbxref=PMID:10819331,PMID:15489334
BAZ2B	Q9UIF8	633	731	633	730	Alternative sequence	ID=VSP_000553;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BAZ2B	Q9UIF8	788	822	789	822	Alternative sequence	ID=VSP_000554;Note=In isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10819331,ECO:0000303|PubMed:14702039;Dbxref=PMID:10819331,PMID:14702039
BAZ2B	Q9UIF8	48	111	71	71	Natural variant	ID=VAR_055549;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs10202670,PMID:17974005
BAZ2B	Q9UIF8	633	731	702	702	Natural variant	ID=VAR_055552;Note=G->V;Dbxref=dbSNP:rs2302924
BAZ2B	Q9UIF8	48	111	95	95	Sequence conflict	Note=L->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2B	Q9UIF8	966	988	986	986	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
BAZ2B	Q9UIF8	2070	2117	2065	2078	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PG1
BAZ2B	Q9UIF8	2070	2117	2080	2082	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PE8
BAZ2B	Q9UIF8	2070	2117	2083	2085	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PG1
BAZ2B	Q9UIF8	2070	2117	2091	2093	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PG1
BAZ2B	Q9UIF8	2070	2117	2094	2096	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E7O
BAZ2B	Q9UIF8	2070	2117	2097	2100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PG1
BAZ2B	Q9UIF8	2070	2117	2107	2115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5PG1
GLB1	P16278	449	493	29	677	Chain	ID=PRO_0000012186;Note=Beta-galactosidase
GLB1	P16278	381	411	29	677	Chain	ID=PRO_0000012186;Note=Beta-galactosidase
GLB1	P16278	419	463	29	677	Chain	ID=PRO_0000012186;Note=Beta-galactosidase
GLB1	P16278	351	381	29	677	Chain	ID=PRO_0000012186;Note=Beta-galactosidase
GLB1	P16278	449	493	464	464	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3THC,ECO:0000244|PDB:3THD,ECO:0000244|PDB:3WEZ,ECO:0000244|PDB:3WF0,ECO:0000244|PDB:3WF1,ECO:0000244|PDB:3WF2,ECO:0000244|PDB:3WF3,ECO:0000244|PDB:3WF4,ECO:0000269|PubMed:16263699,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:22128166,ECO:0000269|PubMed:24737316;Dbxref=PMID:16263699,PMID:19159218,PMID:22128166,PMID:24737316
GLB1	P16278	381	411	377	381	Natural variant	ID=VAR_037941;Note=In GM1G1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17309651;Dbxref=PMID:17309651
GLB1	P16278	351	381	377	381	Natural variant	ID=VAR_037941;Note=In GM1G1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17309651;Dbxref=PMID:17309651
GLB1	P16278	381	411	397	397	Natural variant	ID=VAR_062362;Note=In MPS4B%3B 24.0%25 of wild-type galactosidase activity. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19472408;Dbxref=PMID:19472408
GLB1	P16278	381	411	408	408	Natural variant	ID=VAR_013550;Note=In MPS4B%3B 1.1%25 of wild-type galactosidase activity. Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11511921,ECO:0000269|PubMed:19472408;Dbxref=PMID:11511921,PMID:19472408
GLB1	P16278	419	463	420	420	Natural variant	ID=VAR_062363;Note=In GM1G3%3B decrease in galactosidase activity. T->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16941474,ECO:0000269|PubMed:17664528;Dbxref=PMID:16941474,PMID:17664528
GLB1	P16278	419	463	420	420	Natural variant	ID=VAR_062364;Note=In GM1G1%3B loss of galactosidase activity. T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16941474,ECO:0000269|PubMed:17664528;Dbxref=PMID:16941474,PMID:17664528
GLB1	P16278	419	463	422	422	Natural variant	ID=VAR_062365;Note=In GM1G1. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16941474;Dbxref=PMID:16941474
GLB1	P16278	419	463	434	434	Natural variant	ID=VAR_037942;Note=In GM1-gangliosidosis%3B unclassified clinical type. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17309651;Dbxref=PMID:17309651
GLB1	P16278	419	463	436	436	Natural variant	ID=VAR_026133;Note=Seems to have a modulating action in the expression of the severity of other mutations. L->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12644936,ECO:0000269|PubMed:16941474;Dbxref=dbSNP:rs34421970,PMID:12644936,PMID:16941474
GLB1	P16278	419	463	438	438	Natural variant	ID=VAR_013551;Note=In GM1G3 and MPS4B%3B mild form%3B 5.7%25 of wild-type galactosidase activity. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12393180,ECO:0000269|PubMed:15986423,ECO:0000269|PubMed:19472408;Dbxref=PMID:12393180,PMID:15986423,PMID:19472408
GLB1	P16278	419	463	441	441	Natural variant	ID=VAR_062366;Note=In GM1G1%3B loss of galactosidase activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16941474,ECO:0000269|PubMed:17664528;Dbxref=PMID:16941474,PMID:17664528
GLB1	P16278	419	463	442	442	Natural variant	ID=VAR_062367;Note=In GM1G1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19472408;Dbxref=PMID:19472408
GLB1	P16278	419	463	444	444	Natural variant	ID=VAR_062368;Note=In MPS4B%3B loss of galactosidase activity. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16941474,ECO:0000269|PubMed:17664528;Dbxref=PMID:16941474,PMID:17664528
GLB1	P16278	449	493	457	457	Natural variant	ID=VAR_003335;Note=In GM1G3. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1907800;Dbxref=PMID:1907800
GLB1	P16278	419	463	457	457	Natural variant	ID=VAR_003335;Note=In GM1G3. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1907800;Dbxref=PMID:1907800
GLB1	P16278	449	493	482	482	Natural variant	ID=VAR_008678;Note=In MPS4B%3B loss of galactosidase activity. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7586649;Dbxref=PMID:7586649
GLB1	P16278	449	493	482	482	Natural variant	ID=VAR_003336;Note=In MPS4B and GM1G1%3B severe decrease in galactosidase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10737981,ECO:0000269|PubMed:1487238,ECO:0000269|PubMed:15714521,ECO:0000269|PubMed:16538002,ECO:0000269|PubMed:1928092,ECO:0000269|PubMed:25936995;Dbxref=PMID:10737981,PMID:1487238,PMID:15714521,PMID:16538002,PMID:1928092,PMID:25936995
GLB1	P16278	449	493	484	484	Natural variant	ID=VAR_013552;Note=In MPS4B%3B mild form%3B fibroblasts from MPS4B compound heterozygotes for K-484 and A-500 have 1.9%25 of wild-type galactosidase activity. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12393180;Dbxref=PMID:12393180
GLB1	P16278	449	493	491	491	Natural variant	ID=VAR_008679;Note=In GM1G1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10338095;Dbxref=PMID:10338095
GLB1	P16278	449	493	491	491	Natural variant	ID=VAR_037943;Note=In GM1G1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17309651;Dbxref=PMID:17309651
GLB1	P16278	449	493	493	493	Natural variant	ID=VAR_074063;Note=In GM1G2%3B decrease in galactosidase activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25936995;Dbxref=PMID:25936995
GLB1	P16278	351	381	345	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	351	381	355	357	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	351	381	375	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	381	411	380	384	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	351	381	380	384	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	381	411	385	388	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	381	411	389	392	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	381	411	398	402	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	381	411	407	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	419	463	413	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	419	463	426	433	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	419	463	439	447	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	449	493	450	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	419	463	450	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	449	493	457	459	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	419	463	457	459	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	449	493	462	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	419	463	462	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	449	493	472	478	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
GLB1	P16278	449	493	487	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3THD
ATXN2	Q99700	1172	1248	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	1105	1123	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	679	745	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	548	618	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	423	488	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	276	300	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	679	745	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	548	618	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	423	488	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	276	300	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	679	745	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	548	618	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	679	745	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	548	618	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	423	488	466	466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ATXN2	Q99700	423	488	466	466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ATXN2	Q99700	423	488	478	478	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATXN2	Q99700	423	488	478	478	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATXN2	Q99700	548	618	554	554	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	548	618	554	554	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	679	745	684	684	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
ATXN2	Q99700	679	745	684	684	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
ATXN2	Q99700	679	745	728	728	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ATXN2	Q99700	679	745	728	728	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ATXN2	Q99700	679	745	741	741	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	679	745	741	741	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	679	745	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	548	618	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	423	488	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	276	300	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	679	745	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	548	618	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	423	488	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	276	300	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	276	300	277	300	Alternative sequence	ID=VSP_057286;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATXN2	Q99700	276	300	277	300	Alternative sequence	ID=VSP_057286;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATXN2	Q99700	1172	1248	996	1313	Alternative sequence	ID=VSP_011577;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8896557;Dbxref=PMID:8896557
ATXN2	Q99700	1105	1123	996	1313	Alternative sequence	ID=VSP_011577;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8896557;Dbxref=PMID:8896557
ATXN2	Q99700	1105	1123	1106	1124	Alternative sequence	ID=VSP_057287;Note=In isoform 5. ACPKLPYNKETSPSFYFAI->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATXN2	Q99700	1105	1123	1106	1123	Alternative sequence	ID=VSP_011578;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	1172	1248	1244	1313	Alternative sequence	ID=VSP_011582;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADAMTS16	Q8TE57	535	567	280	1224	Chain	ID=PRO_0000029195;Note=A disintegrin and metalloproteinase with thrombospondin motifs 16
ADAMTS16	Q8TE57	535	567	496	585	Domain	Note=Disintegrin
ADAMTS16	Q8TE57	535	567	518	543	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS16	Q8TE57	535	567	529	550	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS16	Q8TE57	535	567	538	569	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTS16	Q8TE57	535	567	563	574	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BCL2L12	Q9HB09	227	318	1	334	Chain	ID=PRO_0000143072;Note=Bcl-2-like protein 12
BCL2L12	Q9HB09	227	318	311	322	Motif	Note=BH2
BCL2L12	Q9HB09	227	318	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692
BCL2L12	Q9HB09	227	318	243	243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
BCL2L12	Q9HB09	227	318	245	245	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BCL2L12	Q9HB09	227	318	273	273	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
BCL2L12	Q9HB09	227	318	177	334	Alternative sequence	ID=VSP_000523;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCL2L12	Q9HB09	227	318	270	270	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
B3GAT3	O94766	206	303	1	335	Chain	ID=PRO_0000195176;Note=Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
B3GAT3	O94766	206	303	29	335	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B3GAT3	O94766	206	303	243	252	Region	Note=Interaction with galactose moiety of substrate glycoprotein
B3GAT3	O94766	206	303	281	281	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11950836;Dbxref=PMID:11950836
B3GAT3	O94766	206	303	227	227	Site	Note=Interaction with galactose moiety of substrate glycoprotein
B3GAT3	O94766	206	303	300	300	Glycosylation	Note=N-linked (GlcNAc...) asparagine
B3GAT3	O94766	206	303	223	223	Natural variant	ID=VAR_075371;Note=In JDSCD%3B unknown pathological significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26086840;Dbxref=dbSNP:rs372487178,PMID:26086840
B3GAT3	O94766	206	303	277	277	Natural variant	ID=VAR_066624;Note=In JDSCD%3B reduced glucuronyltransferase activity%3B patient fibroblasts have decreased levels of dermatan sulfate%2C chondroitin sulfate and heparan sulfate proteoglycans. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21763480,ECO:0000269|PubMed:24668659;Dbxref=dbSNP:rs387906937,PMID:21763480,PMID:24668659
B3GAT3	O94766	206	303	281	281	Mutagenesis	Note=Absence of enzymatic activity in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA). Does not increase PXYLP1-induced 2-phosphoxylose phosphatase activity in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA). E->A;Ontology_term=ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:24425863,ECO:0000303|PubMed:24425863;Dbxref=PMID:24425863,PMID:24425863
B3GAT3	O94766	206	303	301	301	Mutagenesis	Note=Enzyme inactivation and loss of glycosylation. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10842173;Dbxref=PMID:10842173
B3GAT3	O94766	206	303	201	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	211	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	218	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	224	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	235	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	253	255	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	256	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	260	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	280	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	286	288	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	291	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B3GAT3	O94766	206	303	298	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CU0
B4GALNT2	Q8NHY0	286	315	1	566	Chain	ID=PRO_0000059103;Note=Beta-1%2C4 N-acetylgalactosaminyltransferase 2
B4GALNT2	Q8NHY0	286	315	89	566	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B9D2	Q9BPU9	29	71	1	175	Chain	ID=PRO_0000307674;Note=B9 domain-containing protein 2
B9D2	Q9BPU9	29	71	2	118	Domain	Note=B9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00713
B9D2	Q9BPU9	29	71	36	36	Natural variant	ID=VAR_080463;Note=In JBTS34%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26092869;Dbxref=dbSNP:rs757863670,PMID:26092869
B4GALT3	O60512	268	302	1	393	Chain	ID=PRO_0000080537;Note=Beta-1%2C4-galactosyltransferase 3
B4GALT3	O60512	227	267	1	393	Chain	ID=PRO_0000080537;Note=Beta-1%2C4-galactosyltransferase 3
B4GALT3	O60512	268	302	1	393	Chain	ID=PRO_0000080537;Note=Beta-1%2C4-galactosyltransferase 3
B4GALT3	O60512	227	267	1	393	Chain	ID=PRO_0000080537;Note=Beta-1%2C4-galactosyltransferase 3
B4GALT3	O60512	268	302	32	393	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT3	O60512	227	267	32	393	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT3	O60512	268	302	32	393	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT3	O60512	227	267	32	393	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
B4GALT3	O60512	227	267	260	263	Region	Note=N-acetyl-D-glucosamine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	227	267	260	263	Region	Note=N-acetyl-D-glucosamine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	268	302	291	293	Region	Note=UDP-alpha-D-galactose binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	268	302	291	293	Region	Note=UDP-alpha-D-galactose binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	268	302	291	291	Metal binding	Note=Manganese%3B via tele nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	268	302	291	291	Metal binding	Note=Manganese%3B via tele nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	227	267	258	258	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	227	267	258	258	Binding site	Note=UDP-alpha-D-galactose;Ontology_term=ECO:0000250;evidence=ECO:0000250
B4GALT3	O60512	268	302	146	393	Alternative sequence	ID=VSP_014107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
B4GALT3	O60512	227	267	146	393	Alternative sequence	ID=VSP_014107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
B4GALT3	O60512	268	302	146	393	Alternative sequence	ID=VSP_014107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
B4GALT3	O60512	227	267	146	393	Alternative sequence	ID=VSP_014107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BIRC2	Q13490	455	540	1	618	Chain	ID=PRO_0000122347;Note=Baculoviral IAP repeat-containing protein 2
BIRC2	Q13490	455	540	453	543	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
BIRC2	Q13490	455	540	506	506	Natural variant	ID=VAR_025017;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs34510872
BIRC2	Q13490	455	540	514	514	Sequence conflict	Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305
BIRC2	Q13490	455	540	456	463	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC2	Q13490	455	540	465	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC2	Q13490	455	540	476	484	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC2	Q13490	455	540	485	487	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L9M
BIRC2	Q13490	455	540	490	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC2	Q13490	455	540	502	516	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC2	Q13490	455	540	518	531	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC2	Q13490	455	540	533	540	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3T6P
BIRC3	Q13489	441	526	1	604	Chain	ID=PRO_0000122349;Note=Baculoviral IAP repeat-containing protein 3
BIRC3	Q13489	441	526	1	604	Chain	ID=PRO_0000122349;Note=Baculoviral IAP repeat-containing protein 3
BIRC3	Q13489	441	526	439	529	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
BIRC3	Q13489	441	526	439	529	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
BIRC3	Q13489	441	526	442	443	Site	Note=Breakpoint for translocation to form BIRC3-MALT1
BIRC3	Q13489	441	526	442	443	Site	Note=Breakpoint for translocation to form BIRC3-MALT1
BIRC6	Q9NR09	169	215	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	1136	1166	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	1539	1584	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	1647	1752	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	2284	2356	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	2698	2735	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	3874	3918	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	4500	4537	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	4690	4753	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	4753	4798	1	4857	Chain	ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6
BIRC6	Q9NR09	4690	4753	4576	4704	Region	Note=Ubiquitin-conjugating
BIRC6	Q9NR09	1647	1752	1660	1668	Compositional bias	Note=Poly-Ala
BIRC6	Q9NR09	1647	1752	1710	1710	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
BIRC6	Q9NR09	2284	2356	2319	2319	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
BIRC6	Q9NR09	4500	4537	4524	4533	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4500	4537	4536	4540	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4688	4698	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4704	4707	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4711	4714	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4718	4738	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4741	4745	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4749	4751	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4690	4753	4752	4777	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4753	4798	4752	4777	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
BIRC6	Q9NR09	4753	4798	4788	4810	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG
CYTH4	Q9UIA0	295	319	1	394	Chain	ID=PRO_0000120203;Note=Cytohesin-4
CYTH4	Q9UIA0	295	319	259	375	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
CYTH4	Q9UIA0	295	319	300	300	Binding site	Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250
BMP5	P22003	368	405	317	454	Chain	ID=PRO_0000033867;Note=Bone morphogenetic protein 5
BMP5	P22003	368	405	395	395	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
BMP5	P22003	368	405	353	419	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BMP5	P22003	368	405	382	451	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BMP5	P22003	368	405	386	453	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
BMP5	P22003	368	405	369	405	Alternative sequence	ID=VSP_056841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BRMS1	Q9HCU9	178	209	1	246	Chain	ID=PRO_0000064988;Note=Breast cancer metastasis-suppressor 1
BRMS1	Q9HCU9	178	209	184	184	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BRPF3	Q9ULD4	827	996	1	1205	Chain	ID=PRO_0000211188;Note=Bromodomain and PHD finger-containing protein 3
BRPF3	Q9ULD4	827	996	900	900	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
BRPF3	Q9ULD4	827	996	962	962	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
BRPF3	Q9ULD4	827	996	965	965	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
BRPF3	Q9ULD4	827	996	727	996	Alternative sequence	ID=VSP_055549;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BRINP1	O60477	228	307	20	761	Chain	ID=PRO_0000045766;Note=BMP/retinoic acid-inducible neural-specific protein 1
BRINP1	O60477	228	307	68	251	Domain	Note=MACPF
BRINP1	O60477	228	307	1	285	Alternative sequence	ID=VSP_017021;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
BTC	P35070	94	142	32	178	Chain	ID=PRO_0000300685;Note=Probetacellulin
BTC	P35070	94	142	32	111	Chain	ID=PRO_0000007490;Note=Betacellulin
BTC	P35070	94	142	112	178	Propeptide	ID=PRO_0000007491;Note=Removed in mature form;Ontology_term=ECO:0000250;evidence=ECO:0000250
BTC	P35070	94	142	32	118	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTC	P35070	94	142	119	139	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTC	P35070	94	142	140	178	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTC	P35070	94	142	65	105	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
BTC	P35070	94	142	95	104	Disulfide bond	.
BTC	P35070	94	142	124	124	Natural variant	ID=VAR_029308;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11938093,PMID:15489334
BTC	P35070	94	142	101	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IOX
BTC	P35070	94	142	106	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IP0
BTBD10	Q9BSF8	335	372	1	475	Chain	ID=PRO_0000228985;Note=BTB/POZ domain-containing protein 10
BTBD10	Q9BSF8	269	335	1	475	Chain	ID=PRO_0000228985;Note=BTB/POZ domain-containing protein 10
BTBD10	Q9BSF8	335	372	146	475	Region	Note=Interaction with AKT family members;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80X66
BTBD10	Q9BSF8	269	335	146	475	Region	Note=Interaction with AKT family members;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80X66
BTN3A3	O00478	144	238	30	584	Chain	ID=PRO_0000014534;Note=Butyrophilin subfamily 3 member A3
BTN3A3	O00478	144	238	30	248	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
BTN3A3	O00478	144	238	145	236	Domain	Note=Ig-like V-type 2
BTN3A3	O00478	144	238	166	220	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:22846996;Dbxref=PMID:22846996
BTN3A3	O00478	144	238	229	229	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
BTN3A3	O00478	144	238	133	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	151	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	161	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	176	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	202	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	225	228	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
BTN3A3	O00478	144	238	229	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F8T
CD163L1	Q9NR16	1394	1426	41	1453	Chain	ID=PRO_0000045392;Note=Scavenger receptor cysteine-rich type 1 protein M160
CD163L1	Q9NR16	1357	1394	41	1453	Chain	ID=PRO_0000045392;Note=Scavenger receptor cysteine-rich type 1 protein M160
CD163L1	Q9NR16	469	576	41	1453	Chain	ID=PRO_0000045392;Note=Scavenger receptor cysteine-rich type 1 protein M160
CD163L1	Q9NR16	1357	1394	41	1359	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163L1	Q9NR16	469	576	41	1359	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163L1	Q9NR16	1357	1394	1360	1380	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163L1	Q9NR16	1394	1426	1381	1453	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163L1	Q9NR16	1357	1394	1381	1453	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163L1	Q9NR16	469	576	369	469	Domain	Note=SRCR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163L1	Q9NR16	469	576	476	576	Domain	Note=SRCR 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163L1	Q9NR16	469	576	548	548	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD163L1	Q9NR16	469	576	501	565	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163L1	Q9NR16	469	576	514	575	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163L1	Q9NR16	469	576	545	555	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD163L1	Q9NR16	1394	1426	728	1453	Alternative sequence	ID=VSP_016876;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
CD163L1	Q9NR16	1357	1394	728	1453	Alternative sequence	ID=VSP_016876;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309
CD163L1	Q9NR16	1394	1426	1395	1426	Alternative sequence	ID=VSP_016877;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11086079;Dbxref=PMID:11086079
CD163L1	Q9NR16	469	576	523	523	Natural variant	ID=VAR_059810;Note=L->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086079,ECO:0000269|PubMed:12975309,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:20032174;Dbxref=dbSNP:rs6488268,PMID:11086079,PMID:12975309,PMID:14702039,PMID:15489334,PMID:20032174
CD163L1	Q9NR16	1357	1394	1359	1359	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD163L1	Q9NR16	1357	1394	1359	1359	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD163L1	Q9NR16	1357	1394	1373	1373	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD163L1	Q9NR16	1357	1394	1373	1373	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATRNL1	Q5VV63	939	1012	53	1379	Chain	ID=PRO_0000334650;Note=Attractin-like protein 1
ATRNL1	Q5VV63	1012	1058	53	1379	Chain	ID=PRO_0000334650;Note=Attractin-like protein 1
ATRNL1	Q5VV63	1265	1301	53	1379	Chain	ID=PRO_0000334650;Note=Attractin-like protein 1
ATRNL1	Q5VV63	939	1012	53	1230	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATRNL1	Q5VV63	1012	1058	53	1230	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATRNL1	Q5VV63	1265	1301	1252	1379	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATRNL1	Q5VV63	939	1012	889	939	Domain	Note=PSI 4
ATRNL1	Q5VV63	939	1012	942	1012	Domain	Note=PSI 5
ATRNL1	Q5VV63	1012	1058	942	1012	Domain	Note=PSI 5
ATRNL1	Q5VV63	1012	1058	1014	1059	Domain	Note=Laminin EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
ATRNL1	Q5VV63	1012	1058	1014	1022	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATRNL1	Q5VV63	1012	1058	1016	1028	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATRNL1	Q5VV63	1012	1058	1031	1040	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATRNL1	Q5VV63	1012	1058	1043	1057	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATRNL1	Q5VV63	939	1012	468	1379	Alternative sequence	ID=VSP_033719;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATRNL1	Q5VV63	1012	1058	468	1379	Alternative sequence	ID=VSP_033719;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATRNL1	Q5VV63	1265	1301	468	1379	Alternative sequence	ID=VSP_033719;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATRNL1	Q5VV63	939	1012	989	989	Natural variant	ID=VAR_043446;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9628581;Dbxref=dbSNP:rs1953758,PMID:14702039,PMID:9628581
DNAJC6	O75061	124	165	1	913	Chain	ID=PRO_0000244516;Note=Putative tyrosine-protein phosphatase auxilin
DNAJC6	O75061	124	165	55	222	Domain	Note=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
DNAJC6	O75061	124	165	164	164	Active site	Note=Phosphocysteine intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
DNAJC6	O75061	124	165	152	152	Natural variant	ID=VAR_077925;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26528954;Dbxref=PMID:26528954
AUTS2	Q8WXX7	174	208	1	1259	Chain	ID=PRO_0000064767;Note=Autism susceptibility gene 2 protein
AUTS2	Q8WXX7	563	578	1	1259	Chain	ID=PRO_0000064767;Note=Autism susceptibility gene 2 protein
AUTS2	Q8WXX7	610	634	1	1259	Chain	ID=PRO_0000064767;Note=Autism susceptibility gene 2 protein
AUTS2	Q8WXX7	634	644	1	1259	Chain	ID=PRO_0000064767;Note=Autism susceptibility gene 2 protein
AUTS2	Q8WXX7	563	578	545	646	Compositional bias	Note=Pro-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00015
AUTS2	Q8WXX7	610	634	545	646	Compositional bias	Note=Pro-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00015
AUTS2	Q8WXX7	634	644	545	646	Compositional bias	Note=Pro-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00015
AUTS2	Q8WXX7	174	208	1	555	Alternative sequence	ID=VSP_057063;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:23332918;Dbxref=PMID:23332918
AUTS2	Q8WXX7	563	578	267	1259	Alternative sequence	ID=VSP_043557;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AUTS2	Q8WXX7	610	634	267	1259	Alternative sequence	ID=VSP_043557;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AUTS2	Q8WXX7	634	644	267	1259	Alternative sequence	ID=VSP_043557;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AUTS2	Q8WXX7	610	634	611	634	Alternative sequence	ID=VSP_003792;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:23332918,ECO:0000303|PubMed:9455477;Dbxref=PMID:15489334,PMID:23332918,PMID:9455477
AUTS2	Q8WXX7	634	644	611	634	Alternative sequence	ID=VSP_003792;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:23332918,ECO:0000303|PubMed:9455477;Dbxref=PMID:15489334,PMID:23332918,PMID:9455477
AUTS2	Q8WXX7	174	208	177	177	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCL2L15	Q5TBC7	83	158	1	163	Chain	ID=PRO_0000283003;Note=Bcl-2-like protein 15
BCL2L15	Q5TBC7	83	158	57	163	Alternative sequence	ID=VSP_047628;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15961081;Dbxref=PMID:15961081
BCL2L15	Q5TBC7	83	158	90	90	Natural variant	ID=VAR_031475;Note=D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1217381,PMID:14702039,PMID:15489334
ATP1A3	P13637	51	119	1	1013	Chain	ID=PRO_0000046298;Note=Sodium/potassium-transporting ATPase subunit alpha-3
ATP1A3	P13637	51	119	1	77	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A3	P13637	51	119	78	98	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A3	P13637	51	119	99	121	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A3	P13637	51	119	72	74	Region	Note=Interaction with phosphoinositide-3 kinase;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP1A3	P13637	51	119	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6PIC6
ATP1A4	Q13733	956	989	1	1029	Chain	ID=PRO_0000046303;Note=Sodium/potassium-transporting ATPase subunit alpha-4
ATP1A4	Q13733	956	989	945	957	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A4	Q13733	956	989	958	976	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1A4	Q13733	956	989	977	991	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATXN7L3	Q14CW9	222	245	1	347	Chain	ID=PRO_0000278301;Note=Ataxin-7-like protein 3
ATXN7L3	Q14CW9	222	245	196	263	Domain	Note=SCA7;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03047
ATXN7L3	Q14CW9	222	245	226	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KKT
ATXN7L3	Q14CW9	222	245	231	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KKT
ATP2A1	O14983	73	108	1	1001	Chain	ID=PRO_0000046187;Note=Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
ATP2A1	O14983	73	108	70	89	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2A1	O14983	73	108	90	110	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2A1	O14983	73	108	1	125	Alternative sequence	ID=VSP_054770;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP2C2	O75185	403	437	1	946	Chain	ID=PRO_0000046207;Note=Calcium-transporting ATPase type 2C member 2
ATP2C2	O75185	437	467	1	946	Chain	ID=PRO_0000046207;Note=Calcium-transporting ATPase type 2C member 2
ATP2C2	O75185	553	610	1	946	Chain	ID=PRO_0000046207;Note=Calcium-transporting ATPase type 2C member 2
ATP2C2	O75185	643	660	1	946	Chain	ID=PRO_0000046207;Note=Calcium-transporting ATPase type 2C member 2
ATP2C2	O75185	739	777	1	946	Chain	ID=PRO_0000046207;Note=Calcium-transporting ATPase type 2C member 2
ATP2C2	O75185	403	437	353	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	437	467	353	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	553	610	353	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	643	660	353	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	739	777	353	750	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	739	777	751	771	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	739	777	772	804	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2C2	O75185	739	777	768	768	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2C2	O75185	739	777	772	772	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2C2	O75185	403	437	411	411	Natural variant	ID=VAR_047935;Note=G->S;Dbxref=dbSNP:rs2303853
ATP2C2	O75185	437	467	466	466	Natural variant	ID=VAR_047936;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs247897,PMID:14702039
ATP2C2	O75185	553	610	604	604	Natural variant	ID=VAR_070929;Note=L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs62640926,PMID:17974005
ATE1	O95260	314	325	1	518	Chain	ID=PRO_0000195088;Note=Arginyl-tRNA--protein transferase 1
ATE1	O95260	271	314	1	518	Chain	ID=PRO_0000195088;Note=Arginyl-tRNA--protein transferase 1
ATE1	O95260	112	194	1	518	Chain	ID=PRO_0000195088;Note=Arginyl-tRNA--protein transferase 1
ATE1	O95260	57	77	1	518	Chain	ID=PRO_0000195088;Note=Arginyl-tRNA--protein transferase 1
ATE1	O95260	112	194	169	169	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
ATE1	O95260	314	325	274	314	Alternative sequence	ID=VSP_000336;Note=In isoform ATE1-2. VVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQ->LVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9858543;Dbxref=PMID:15489334,PMID:9858543
ATE1	O95260	271	314	274	314	Alternative sequence	ID=VSP_000336;Note=In isoform ATE1-2. VVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQ->LVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9858543;Dbxref=PMID:15489334,PMID:9858543
ATG9B	Q674R7	220	273	1	924	Chain	ID=PRO_0000314867;Note=Autophagy-related protein 9B
ATG9B	Q674R7	220	273	208	228	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATG9B	Q674R7	220	273	229	276	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATG9B	Q674R7	220	273	1	514	Alternative sequence	ID=VSP_030410;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATP7A	Q04656	203	445	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	445	514	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	569	623	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	724	802	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	927	972	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	972	1037	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	1037	1098	1	1500	Chain	ID=PRO_0000046311;Note=Copper-transporting ATPase 1
ATP7A	Q04656	203	445	1	653	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	445	514	1	653	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	569	623	1	653	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	724	802	715	734	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	724	802	735	741	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	724	802	742	762	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	724	802	763	781	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	724	802	782	802	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	927	972	803	936	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	927	972	937	959	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	927	972	960	989	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	972	1037	960	989	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	972	1037	990	1011	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	972	1037	1012	1356	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	1037	1098	1012	1356	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	203	445	172	238	Domain	Note=HMA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7A	Q04656	203	445	278	344	Domain	Note=HMA 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7A	Q04656	203	445	378	444	Domain	Note=HMA 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7A	Q04656	445	514	489	555	Domain	Note=HMA 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7A	Q04656	569	623	565	631	Domain	Note=HMA 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7A	Q04656	203	445	355	362	Compositional bias	Note=Poly-Ser
ATP7A	Q04656	1037	1098	1044	1044	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP7A	Q04656	203	445	270	270	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATP7A	Q04656	203	445	327	327	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATP7A	Q04656	203	445	339	339	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
ATP7A	Q04656	203	445	353	353	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70705
ATP7A	Q04656	203	445	357	357	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATP7A	Q04656	203	445	362	362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q64430
ATP7A	Q04656	972	1037	975	975	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7A	Q04656	203	445	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	445	514	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	569	623	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	724	802	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	927	972	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	972	1037	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	1037	1098	42	1038	Alternative sequence	ID=VSP_000424;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10079814,ECO:0000303|PubMed:9693104;Dbxref=PMID:10079814,PMID:9693104
ATP7A	Q04656	203	445	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	445	514	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	569	623	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	724	802	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	927	972	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	972	1037	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	1037	1098	82	1499	Alternative sequence	ID=VSP_000423;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	724	802	725	802	Alternative sequence	ID=VSP_000425;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	724	802	727	727	Natural variant	ID=VAR_000700;Note=In MNKD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8981948;Dbxref=PMID:8981948
ATP7A	Q04656	724	802	767	767	Natural variant	ID=VAR_010000;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7977350;Dbxref=dbSNP:rs2227291,PMID:7977350
ATP7A	Q04656	972	1037	994	994	Natural variant	ID=VAR_063882;Note=In DSMAX3%3B demonstrates impaired intracellular trafficking compared to control with some of the mutant protein remaining in the Golgi apparatus after exposure to copper. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20170900;Dbxref=PMID:20170900
ATP7A	Q04656	972	1037	1000	1000	Natural variant	ID=VAR_010003;Note=In MNKD%3B decreased protein abundance%3B increased protein degradation%3B does not affect interaction with ATOX1%3B does not affect interaction with COMMD1%3B subcellular location restricted to TGN%3B does not localizes to the plasma membrane in response to elevated copper levels. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15981243,ECO:0000269|PubMed:21667063;Dbxref=PMID:15981243,PMID:21667063
ATP7A	Q04656	972	1037	1006	1006	Natural variant	ID=VAR_000701;Note=In MNKD. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8981948;Dbxref=PMID:8981948
ATP7A	Q04656	972	1037	1007	1007	Natural variant	ID=VAR_023267;Note=In MNKD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15981243;Dbxref=PMID:15981243
ATP7A	Q04656	972	1037	1015	1015	Natural variant	ID=VAR_023268;Note=In MNKD. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15981243;Dbxref=PMID:15981243
ATP7A	Q04656	972	1037	1019	1019	Natural variant	ID=VAR_000702;Note=In MNKD. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8981948;Dbxref=PMID:8981948
ATP7A	Q04656	1037	1098	1044	1044	Natural variant	ID=VAR_023269;Note=In MNKD. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15981243;Dbxref=PMID:15981243
ATP7A	Q04656	1037	1098	1048	1048	Natural variant	ID=VAR_068831;Note=In MNKD. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22992316;Dbxref=PMID:22992316
ATP7A	Q04656	203	445	336	336	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	203	445	336	336	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	445	514	446	446	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	724	802	725	725	Sequence conflict	Note=F->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7A	Q04656	203	445	199	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q8L
ATP7A	Q04656	203	445	207	209	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q8L
ATP7A	Q04656	203	445	210	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q8L
ATP7A	Q04656	203	445	217	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S6O
ATP7A	Q04656	203	445	222	231	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q8L
ATP7A	Q04656	203	445	236	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S6U
ATP7A	Q04656	203	445	242	244	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q8L
ATP7A	Q04656	203	445	277	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	305	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	312	315	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	316	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	324	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GA7
ATP7A	Q04656	203	445	329	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	340	342	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	344	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9O
ATP7A	Q04656	203	445	377	384	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	388	400	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	408	411	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	412	415	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	416	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	423	425	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	428	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	203	445	441	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	445	514	441	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AW0
ATP7A	Q04656	445	514	488	495	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y3J
ATP7A	Q04656	445	514	497	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y3J
ATP7A	Q04656	445	514	502	510	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y3J
ATP7A	Q04656	445	514	513	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Y3J
ATP7A	Q04656	569	623	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	575	577	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	578	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	592	598	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	599	602	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	603	608	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	610	613	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	569	623	614	626	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YJR
ATP7A	Q04656	1037	1098	1055	1061	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KMV
ATP7A	Q04656	1037	1098	1065	1067	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KMV
ATP7A	Q04656	1037	1098	1070	1079	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KMV
ATP7A	Q04656	1037	1098	1080	1082	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KMV
ATP7A	Q04656	1037	1098	1083	1085	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KMV
ATP7A	Q04656	1037	1098	1087	1100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KMV
ATP7B	P35670	1233	1301	1	1465	Chain	ID=PRO_0000046314;Note=Copper-transporting ATPase 2
ATP7B	P35670	1137	1185	1	1465	Chain	ID=PRO_0000046314;Note=Copper-transporting ATPase 2
ATP7B	P35670	1020	1081	1	1465	Chain	ID=PRO_0000046314;Note=Copper-transporting ATPase 2
ATP7B	P35670	955	1020	1	1465	Chain	ID=PRO_0000046314;Note=Copper-transporting ATPase 2
ATP7B	P35670	910	955	1	1465	Chain	ID=PRO_0000046314;Note=Copper-transporting ATPase 2
ATP7B	P35670	707	785	1	1465	Chain	ID=PRO_0000046314;Note=Copper-transporting ATPase 2
ATP7B	P35670	707	785	698	717	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	707	785	718	724	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	707	785	725	745	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	707	785	746	764	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	707	785	765	785	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	910	955	786	919	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	910	955	920	942	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	955	1020	943	972	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	910	955	943	972	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	955	1020	973	994	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	1233	1301	995	1322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	1137	1185	995	1322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	1020	1081	995	1322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	955	1020	995	1322	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP7B	P35670	1020	1081	1027	1027	Active site	Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP7B	P35670	1233	1301	1267	1267	Metal binding	Note=Magnesium;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7B	P35670	1233	1301	1271	1271	Metal binding	Note=Magnesium;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280
ATP7B	P35670	1233	1301	234	1465	Alternative sequence	ID=VSP_059175;Note=In isoform 5. RPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI->ETFIFC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28107647;Dbxref=PMID:28107647
ATP7B	P35670	1137	1185	234	1465	Alternative sequence	ID=VSP_059175;Note=In isoform 5. RPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI->ETFIFC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28107647;Dbxref=PMID:28107647
ATP7B	P35670	1020	1081	234	1465	Alternative sequence	ID=VSP_059175;Note=In isoform 5. RPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI->ETFIFC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28107647;Dbxref=PMID:28107647
ATP7B	P35670	955	1020	234	1465	Alternative sequence	ID=VSP_059175;Note=In isoform 5. RPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI->ETFIFC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28107647;Dbxref=PMID:28107647
ATP7B	P35670	910	955	234	1465	Alternative sequence	ID=VSP_059175;Note=In isoform 5. RPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI->ETFIFC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28107647;Dbxref=PMID:28107647
ATP7B	P35670	707	785	234	1465	Alternative sequence	ID=VSP_059175;Note=In isoform 5. RPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI->ETFIFC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28107647;Dbxref=PMID:28107647
ATP7B	P35670	707	785	624	785	Alternative sequence	ID=VSP_000426;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8298641;Dbxref=PMID:8298641
ATP7B	P35670	955	1020	911	955	Alternative sequence	ID=VSP_000427;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8298641;Dbxref=PMID:8298641
ATP7B	P35670	910	955	911	955	Alternative sequence	ID=VSP_000427;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8298641;Dbxref=PMID:8298641
ATP7B	P35670	955	1020	938	955	Alternative sequence	ID=VSP_016560;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8250934;Dbxref=PMID:8250934
ATP7B	P35670	910	955	938	955	Alternative sequence	ID=VSP_016560;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8250934;Dbxref=PMID:8250934
ATP7B	P35670	707	785	708	708	Natural variant	ID=VAR_000717;Note=In WD. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11093740;Dbxref=dbSNP:rs121908000,PMID:11093740
ATP7B	P35670	707	785	710	710	Natural variant	ID=VAR_010010;Note=In WD. G->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:9887381;Dbxref=PMID:11690702,PMID:9887381
ATP7B	P35670	707	785	710	710	Natural variant	ID=VAR_000718;Note=In WD. G->R
ATP7B	P35670	707	785	710	710	Natural variant	ID=VAR_000719;Note=In WD%3B decreased copper transport activity%3B no effect on ATPase activity. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:22763723,ECO:0000269|PubMed:23333878;Dbxref=dbSNP:rs137853285,PMID:10544227,PMID:11690702,PMID:15967699,PMID:22240481,PMID:22763723,PMID:23333878
ATP7B	P35670	707	785	710	710	Natural variant	ID=VAR_044461;Note=In WD. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16088907;Dbxref=PMID:16088907
ATP7B	P35670	707	785	711	711	Natural variant	ID=VAR_000720;Note=In WD. G->E
ATP7B	P35670	707	785	711	711	Natural variant	ID=VAR_009006;Note=In WD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10544227;Dbxref=PMID:10544227
ATP7B	P35670	707	785	711	711	Natural variant	ID=VAR_009007;Note=In WD. G->W;Dbxref=dbSNP:rs1394999756
ATP7B	P35670	707	785	713	713	Natural variant	ID=VAR_000721;Note=In WD. Y->C;Dbxref=dbSNP:rs756883878
ATP7B	P35670	707	785	721	721	Natural variant	ID=VAR_023016;Note=In WD. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12325021;Dbxref=dbSNP:rs765667658,PMID:12325021
ATP7B	P35670	707	785	723	723	Natural variant	ID=VAR_000722;Note=R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:9482578;Dbxref=PMID:11405812,PMID:9482578
ATP7B	P35670	707	785	729	729	Natural variant	ID=VAR_076733;Note=In WD%3B unknown pathological significance. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21645214;Dbxref=dbSNP:rs773447981,PMID:21645214
ATP7B	P35670	707	785	731	731	Natural variant	ID=VAR_076699;Note=In WD%3B unknown pathological significance. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=PMID:23518715
ATP7B	P35670	707	785	732	732	Natural variant	ID=VAR_076734;Note=In WD%3B unknown pathological significance. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235335;Dbxref=PMID:23235335
ATP7B	P35670	707	785	732	732	Natural variant	ID=VAR_076735;Note=In WD%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235335;Dbxref=PMID:23235335
ATP7B	P35670	707	785	737	737	Natural variant	ID=VAR_023017;Note=In WD%3B unknown pathological significance. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967699;Dbxref=PMID:15967699
ATP7B	P35670	707	785	741	741	Natural variant	ID=VAR_010011;Note=In WD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9887381;Dbxref=dbSNP:rs770533110,PMID:9887381
ATP7B	P35670	707	785	744	744	Natural variant	ID=VAR_009008;Note=In WD. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21682854;Dbxref=PMID:21682854
ATP7B	P35670	707	785	745	745	Natural variant	ID=VAR_076700;Note=In WD%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=PMID:23518715
ATP7B	P35670	707	785	747	747	Natural variant	ID=VAR_000723;Note=In WD. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671269;Dbxref=PMID:9671269
ATP7B	P35670	707	785	756	756	Natural variant	ID=VAR_044462;Note=In WD. A->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16088907,ECO:0000269|PubMed:23235335;Dbxref=PMID:16088907,PMID:23235335
ATP7B	P35670	707	785	760	760	Natural variant	ID=VAR_023018;Note=In WD%3B decreased copper transport activity%3B increased ATPase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11180609,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:22240481;Dbxref=dbSNP:rs766907687,PMID:11180609,PMID:11690702,PMID:22240481
ATP7B	P35670	707	785	765	765	Natural variant	ID=VAR_023019;Note=In WD. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14986826;Dbxref=PMID:14986826
ATP7B	P35670	707	785	765	765	Natural variant	ID=VAR_076811;Note=In WD%3B unknown pathological significance. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22484412;Dbxref=dbSNP:rs28942075,PMID:22484412
ATP7B	P35670	707	785	765	765	Natural variant	ID=VAR_000724;Note=In WD%3B decreased copper transport activity%3B increased ATPase activity%3B decreased localization to TGN and reduced capacity to redistribute to cytoplasmic vesicles under high-copper levels. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10942420,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:21682854,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:8533760,ECO:0000269|PubMed:9482578,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs28942075,PMID:10942420,PMID:11690702,PMID:21682854,PMID:22240481,PMID:23333878,PMID:8533760,PMID:9482578,PMID:9837819
ATP7B	P35670	707	785	766	766	Natural variant	ID=VAR_044463;Note=In WD. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16088907;Dbxref=dbSNP:rs121907997,PMID:16088907
ATP7B	P35670	707	785	766	766	Natural variant	ID=VAR_044464;Note=In WD. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15557537;Dbxref=dbSNP:rs121907997,PMID:15557537
ATP7B	P35670	707	785	768	768	Natural variant	ID=VAR_023020;Note=In WD. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12544487;Dbxref=PMID:12544487
ATP7B	P35670	707	785	769	769	Natural variant	ID=VAR_023021;Note=In WD. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10790207;Dbxref=PMID:10790207
ATP7B	P35670	707	785	769	769	Natural variant	ID=VAR_009009;Note=In WD. M->R;Dbxref=dbSNP:rs772595172
ATP7B	P35670	707	785	769	769	Natural variant	ID=VAR_000725;Note=In WD%3B possible decreased copper transport activity%3B increased ATPase activity. M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs193922103,PMID:11405812,PMID:11690702,PMID:17949296,PMID:22240481,PMID:23518715,PMID:9837819
ATP7B	P35670	707	785	776	776	Natural variant	ID=VAR_044465;Note=In WD. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16283883;Dbxref=PMID:16283883
ATP7B	P35670	707	785	776	776	Natural variant	ID=VAR_000726;Note=In WD%3B unknown pathological significance%3B no effect on copper transport activity%3B decreased localization to TGN and reduced capacity to redistribute to cytoplasmic vesicles under high-copper levels. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10942420,ECO:0000269|PubMed:9837819;Dbxref=PMID:10942420,PMID:9837819
ATP7B	P35670	707	785	778	778	Natural variant	ID=VAR_000727;Note=In WD. R->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11216666,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:16207219,ECO:0000269|PubMed:16283883,ECO:0000269|PubMed:21682854,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:8533760;Dbxref=dbSNP:rs137853284,PMID:11216666,PMID:15967699,PMID:16207219,PMID:16283883,PMID:21682854,PMID:23333878,PMID:8533760
ATP7B	P35670	707	785	778	778	Natural variant	ID=VAR_000728;Note=In WD%3B most common mutation%3B decreased copper transport activity%3B extensively localized throughout the cell in the distribution pattern of the endoplasmic reticulum. R->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10453196,ECO:0000269|PubMed:10721669,ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:10942420,ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:12376745,ECO:0000269|PubMed:12544487,ECO:0000269|PubMed:14966923,ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:16649058,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:23235335,ECO:0000269|PubMed:25704634,ECO:0000269|PubMed:8782057,ECO:0000269|PubMed:9452121,ECO:0000269|PubMed:9554743,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs28942074,PMID:10453196,PMID:10721669,PMID:10790207,PMID:10942420,PMID:11405812,PMID:12376745,PMID:12544487,PMID:14966923,PMID:14986826,PMID:16649058,PMID:21645214,PMID:23235335,PMID:25704634,PMID:8782057,PMID:9452121,PMID:9554743,PMID:9837819
ATP7B	P35670	707	785	778	778	Natural variant	ID=VAR_000729;Note=In WD%3B decreased copper transport activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:23235335,ECO:0000269|PubMed:8782057,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs28942074,PMID:11405812,PMID:17949296,PMID:21645214,PMID:23235335,PMID:8782057,PMID:9837819
ATP7B	P35670	707	785	778	778	Natural variant	ID=VAR_000730;Note=In WD. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:11243728,ECO:0000269|PubMed:16207219,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs137853284,PMID:10790207,PMID:11243728,PMID:16207219,PMID:17949296,PMID:23333878,PMID:23518715,PMID:9671269
ATP7B	P35670	707	785	779	779	Natural variant	ID=VAR_076971;Note=In WD. W->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22763723,ECO:0000269|PubMed:23159873;Dbxref=dbSNP:rs751798708,PMID:22763723,PMID:23159873
ATP7B	P35670	910	955	918	918	Natural variant	ID=VAR_023025;Note=In WD. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967699;Dbxref=PMID:15967699
ATP7B	P35670	910	955	918	918	Natural variant	ID=VAR_000738;Note=In WD. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs540935874,PMID:9671269
ATP7B	P35670	910	955	919	919	Natural variant	ID=VAR_000739;Note=In WD. R->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10453196,ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:12376745,ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:23235335,ECO:0000269|PubMed:25704634,ECO:0000269|PubMed:9452121;Dbxref=dbSNP:rs121907993,PMID:10453196,PMID:10790207,PMID:11405812,PMID:12376745,PMID:14986826,PMID:21645214,PMID:23235335,PMID:25704634,PMID:9452121
ATP7B	P35670	910	955	919	919	Natural variant	ID=VAR_000740;Note=In WD. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs121907993,PMID:17949296,PMID:23333878,PMID:23518715,PMID:9671269
ATP7B	P35670	910	955	921	921	Natural variant	ID=VAR_000741;Note=In WD. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs1230241288,PMID:9671269
ATP7B	P35670	910	955	921	921	Natural variant	ID=VAR_076740;Note=In WD%3B unknown pathological significance. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs1052485948,PMID:23235335
ATP7B	P35670	910	955	929	929	Natural variant	ID=VAR_076741;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs534960245,PMID:11405812,PMID:23235335
ATP7B	P35670	910	955	933	933	Natural variant	ID=VAR_000742;Note=In WD%3B unknown pathological significance. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671269;Dbxref=PMID:9671269
ATP7B	P35670	910	955	935	935	Natural variant	ID=VAR_000743;Note=In WD. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:16649058,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:24476933;Dbxref=dbSNP:rs750019452,PMID:11405812,PMID:14986826,PMID:16649058,PMID:17949296,PMID:24476933
ATP7B	P35670	910	955	936	936	Natural variant	ID=VAR_076701;Note=In WD%3B unknown pathological significance. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs367855110,PMID:23518715
ATP7B	P35670	910	955	939	939	Natural variant	ID=VAR_076813;Note=In WD. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22484412;Dbxref=dbSNP:rs1057517310,PMID:22484412
ATP7B	P35670	910	955	943	943	Natural variant	ID=VAR_044468;Note=In WD. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16088907;Dbxref=PMID:16088907
ATP7B	P35670	910	955	943	943	Natural variant	ID=VAR_000744;Note=In WD. G->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:14966923,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs779323689,PMID:11405812,PMID:14966923,PMID:21645214,PMID:23235335
ATP7B	P35670	910	955	943	943	Natural variant	ID=VAR_000745;Note=In WD%3B no effect on copper transport activity%3B normally localized to TGN network but unable to redistribute to cytoplasmic vesicles in response to copper. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10942420,ECO:0000269|PubMed:15952988,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs28942076,PMID:10942420,PMID:15952988,PMID:21645214,PMID:23333878,PMID:9837819
ATP7B	P35670	910	955	949	949	Natural variant	ID=VAR_023026;Note=In WD. V->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15024742,ECO:0000269|PubMed:9887381;Dbxref=dbSNP:rs1169959260,PMID:15024742,PMID:9887381
ATP7B	P35670	910	955	952	952	Natural variant	ID=VAR_000746;Note=R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:18373411,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:7833924,ECO:0000269|PubMed:8298639,ECO:0000269|Ref.2;Dbxref=dbSNP:rs732774,PMID:11405812,PMID:18373411,PMID:23333878,PMID:7833924,PMID:8298639
ATP7B	P35670	955	1020	967	967	Natural variant	ID=VAR_010013;Note=In WD. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8938442;Dbxref=dbSNP:rs60003608,PMID:8938442
ATP7B	P35670	955	1020	969	969	Natural variant	ID=VAR_000747;Note=In WD%3B decreased copper transport activity%3B increased ATPase activity%3B no effect on localization. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:11216666,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:16207219,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:8533760,ECO:0000269|PubMed:9482578;Dbxref=dbSNP:rs121907996,PMID:10544227,PMID:11216666,PMID:11690702,PMID:15967699,PMID:16207219,PMID:21645214,PMID:22240481,PMID:23333878,PMID:8533760,PMID:9482578
ATP7B	P35670	955	1020	969	969	Natural variant	ID=VAR_076768;Note=In WD%3B unknown pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17949296;Dbxref=dbSNP:rs774028495,PMID:17949296
ATP7B	P35670	955	1020	971	971	Natural variant	ID=VAR_058927;Note=In WD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18373411;Dbxref=dbSNP:rs770340441,PMID:18373411
ATP7B	P35670	955	1020	974	974	Natural variant	ID=VAR_058928;Note=In WD. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18373411;Dbxref=dbSNP:rs201061621,PMID:18373411
ATP7B	P35670	955	1020	975	975	Natural variant	ID=VAR_023027;Note=In WD. S->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs778163447,PMID:14986826,PMID:23235335
ATP7B	P35670	955	1020	977	977	Natural variant	ID=VAR_000748;Note=In WD%3B loss of copper transport activity. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15952988,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:16283883,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:21682854,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:8938442,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs72552255,PMID:15952988,PMID:15967699,PMID:16283883,PMID:17949296,PMID:21645214,PMID:21682854,PMID:23518715,PMID:8938442,PMID:9837819
ATP7B	P35670	955	1020	980	980	Natural variant	ID=VAR_076742;Note=In WD%3B unknown pathological significance. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs1038582488,PMID:23235335
ATP7B	P35670	955	1020	982	982	Natural variant	ID=VAR_077616;Note=In WD%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24476933;Dbxref=dbSNP:rs750407121,PMID:24476933
ATP7B	P35670	955	1020	982	982	Natural variant	ID=VAR_076769;Note=In WD%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17949296;Dbxref=PMID:17949296
ATP7B	P35670	955	1020	985	985	Natural variant	ID=VAR_009012;Note=In WD. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10447265;Dbxref=PMID:10447265
ATP7B	P35670	955	1020	987	987	Natural variant	ID=VAR_076743;Note=In WD%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235335;Dbxref=PMID:23235335
ATP7B	P35670	955	1020	988	988	Natural variant	ID=VAR_044469;Note=In WD. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16283883;Dbxref=dbSNP:rs199623434,PMID:16283883
ATP7B	P35670	955	1020	990	990	Natural variant	ID=VAR_076814;Note=In WD%3B unknown pathological significance. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25982861;Dbxref=PMID:25982861
ATP7B	P35670	955	1020	991	991	Natural variant	ID=VAR_044470;Note=In WD%3B yeast complementation assays show that the variant mildly rescue iron-uptake deficiency of yeast mutant ccc2. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16088907,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:20333758,ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs41292782,PMID:16088907,PMID:17949296,PMID:20333758,PMID:23518715
ATP7B	P35670	955	1020	992	992	Natural variant	ID=VAR_044471;Note=In WD. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15811015;Dbxref=PMID:15811015
ATP7B	P35670	955	1020	992	992	Natural variant	ID=VAR_000749;Note=In WD%3B common mutation%3B decreased copper transport activity%3B no effect on ATPase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:16283883,ECO:0000269|PubMed:16649058,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:23235335,ECO:0000269|PubMed:25704634,ECO:0000269|PubMed:28856630,ECO:0000269|PubMed:9671269,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs201038679,PMID:11690702,PMID:14986826,PMID:16283883,PMID:16649058,PMID:21645214,PMID:22240481,PMID:23235335,PMID:25704634,PMID:28856630,PMID:9671269,PMID:9837819
ATP7B	P35670	955	1020	995	995	Natural variant	ID=VAR_000750;Note=In WD%3B unknown pathological significance%3B no effect on copper transport activity. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:9837819;Dbxref=dbSNP:rs777791532,PMID:23518715,PMID:9837819
ATP7B	P35670	955	1020	996	996	Natural variant	ID=VAR_044472;Note=In WD. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16088907;Dbxref=dbSNP:rs770782111,PMID:16088907
ATP7B	P35670	955	1020	998	998	Natural variant	ID=VAR_067336;Note=In WD. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21682854;Dbxref=PMID:21682854
ATP7B	P35670	955	1020	1000	1000	Natural variant	ID=VAR_044473;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16088907,ECO:0000269|PubMed:20333758;Dbxref=dbSNP:rs751078884,PMID:16088907,PMID:20333758
ATP7B	P35670	955	1020	1003	1003	Natural variant	ID=VAR_000751;Note=In WD. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:15811015,ECO:0000269|PubMed:16207219,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs201497300,PMID:10790207,PMID:15811015,PMID:16207219,PMID:23333878,PMID:9671269
ATP7B	P35670	955	1020	1003	1003	Natural variant	ID=VAR_009013;Note=In WD. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:25982861;Dbxref=dbSNP:rs775055397,PMID:10544227,PMID:23333878,PMID:25982861
ATP7B	P35670	955	1020	1004	1004	Natural variant	ID=VAR_058929;Note=In WD. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18373411;Dbxref=dbSNP:rs587783307,PMID:18373411
ATP7B	P35670	955	1020	1010	1010	Natural variant	ID=VAR_079550;Note=In WD%3B unknown pathological significance. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28856630;Dbxref=PMID:28856630
ATP7B	P35670	955	1020	1010	1010	Natural variant	ID=VAR_076815;Note=In WD%3B unknown pathological significance. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25982861;Dbxref=dbSNP:rs747584649,PMID:25982861
ATP7B	P35670	955	1020	1010	1010	Natural variant	ID=VAR_076744;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21645214;Dbxref=PMID:21645214
ATP7B	P35670	955	1020	1012	1012	Natural variant	ID=VAR_076770;Note=In WD%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17949296;Dbxref=PMID:17949296
ATP7B	P35670	955	1020	1012	1012	Natural variant	ID=VAR_076771;Note=In WD%3B unknown pathological significance. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17949296;Dbxref=dbSNP:rs772089544,PMID:17949296
ATP7B	P35670	955	1020	1017	1017	Natural variant	ID=VAR_076702;Note=In WD%3B unknown pathological significance. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs755851188,PMID:23518715
ATP7B	P35670	955	1020	1018	1018	Natural variant	ID=VAR_000752;Note=In WD. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs371840514,PMID:15967699,PMID:17949296,PMID:9671269
ATP7B	P35670	1020	1081	1021	1021	Natural variant	ID=VAR_076703;Note=In WD%3B unknown pathological significance. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs776490710,PMID:23518715
ATP7B	P35670	1020	1081	1024	1024	Natural variant	ID=VAR_076745;Note=In WD%3B unknown pathological significance. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21645214;Dbxref=PMID:21645214
ATP7B	P35670	1020	1081	1029	1029	Natural variant	ID=VAR_044474;Note=In WD. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10453196,ECO:0000269|PubMed:21645214;Dbxref=PMID:10453196,PMID:21645214
ATP7B	P35670	1020	1081	1031	1031	Natural variant	ID=VAR_076746;Note=In WD%3B unknown pathological significance. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17823867,ECO:0000269|PubMed:21645214;Dbxref=PMID:17823867,PMID:21645214
ATP7B	P35670	1020	1081	1031	1031	Natural variant	ID=VAR_010014;Note=In WD. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9887381;Dbxref=PMID:9887381
ATP7B	P35670	1020	1081	1033	1033	Natural variant	ID=VAR_009014;Note=In WD. T->A
ATP7B	P35670	1020	1081	1033	1033	Natural variant	ID=VAR_023028;Note=In WD. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967699;Dbxref=PMID:15967699
ATP7B	P35670	1020	1081	1035	1035	Natural variant	ID=VAR_000753;Note=In WD. G->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10453196,ECO:0000269|PubMed:21645214;Dbxref=dbSNP:rs753594031,PMID:10453196,PMID:21645214
ATP7B	P35670	1020	1081	1036	1036	Natural variant	ID=VAR_075337;Note=In WD%3B copper ion transmembrane transporter activity. V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:26004889;Dbxref=dbSNP:rs761147984,PMID:23333878,PMID:26004889
ATP7B	P35670	1020	1081	1038	1038	Natural variant	ID=VAR_010015;Note=In WD. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8980283;Dbxref=dbSNP:rs59959366,PMID:8980283
ATP7B	P35670	1020	1081	1041	1041	Natural variant	ID=VAR_009015;Note=In WD. R->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10194254,ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:11405812;Dbxref=PMID:10194254,PMID:10544227,PMID:11405812
ATP7B	P35670	1020	1081	1041	1041	Natural variant	ID=VAR_000754;Note=In WD%3B unknown pathological significance%3B no effect on copper transport activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:18203200,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:25982861,ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs746485916,PMID:10544227,PMID:15967699,PMID:18203200,PMID:23333878,PMID:23518715,PMID:25982861,PMID:9671269
ATP7B	P35670	1020	1081	1043	1043	Natural variant	ID=VAR_000755;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20333758,ECO:0000269|PubMed:25982861;Dbxref=dbSNP:rs1412025509,PMID:20333758,PMID:25982861
ATP7B	P35670	1020	1081	1052	1052	Natural variant	ID=VAR_009016;Note=In WD%3B loss of copper transport activity%3B no effect on ATPase activity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22240481;Dbxref=dbSNP:rs778543794,PMID:22240481
ATP7B	P35670	1020	1081	1058	1058	Natural variant	ID=VAR_076704;Note=In WD%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=PMID:23518715
ATP7B	P35670	1020	1081	1061	1061	Natural variant	ID=VAR_009017;Note=In WD. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:11216666,ECO:0000269|PubMed:15952988,ECO:0000269|PubMed:25982861;Dbxref=dbSNP:rs764131178,PMID:10544227,PMID:11216666,PMID:15952988,PMID:25982861
ATP7B	P35670	1020	1081	1063	1063	Natural variant	ID=VAR_009018;Note=In WD. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:21682854;Dbxref=dbSNP:rs587783309,PMID:10544227,PMID:15967699,PMID:21682854
ATP7B	P35670	1020	1081	1064	1064	Natural variant	ID=VAR_000756;Note=In WD%3B does not bind ATP%3B the mutant is stable and is properly targeted to the TGN. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21398519,ECO:0000269|PubMed:9482578;Dbxref=dbSNP:rs374094065,PMID:21398519,PMID:9482578
ATP7B	P35670	1020	1081	1064	1064	Natural variant	ID=VAR_000757;Note=In WD%3B loss of copper transport activity%3B loss of ATPase activity. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:18203200,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:8533760;Dbxref=dbSNP:rs376910645,PMID:15967699,PMID:17949296,PMID:18203200,PMID:22240481,PMID:8533760
ATP7B	P35670	1020	1081	1065	1065	Natural variant	ID=VAR_044475;Note=In WD. A->P
ATP7B	P35670	1020	1081	1068	1068	Natural variant	ID=VAR_009019;Note=In WD%3B common mutation. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10544227;Dbxref=PMID:10544227
ATP7B	P35670	1020	1081	1069	1069	Natural variant	ID=VAR_000758;Note=In WD%3B common mutation%3B decreased copper transport activity%3B loss of ATPase activity%3B cannot form an acylphosphate intermediate during catalysis%3B does not alter the folding of the nucleotide-binding domain%3B decreased stability%3B does not localizes to late endosomes. H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10051024,ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:11216666,ECO:0000269|PubMed:11231950,ECO:0000269|PubMed:11243728,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:12551905,ECO:0000269|PubMed:15952988,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:16207219,ECO:0000269|PubMed:16283883,ECO:0000269|PubMed:21398519,ECO:0000269|PubMed:21682854,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:22763723,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:8298641,ECO:0000269|PubMed:9482578,ECO:0000269|PubMed:9887381;Dbxref=dbSNP:rs76151636,PMID:10051024,PMID:10544227,PMID:11216666,PMID:11231950,PMID:11243728,PMID:11690702,PMID:12551905,PMID:15952988,PMID:15967699,PMID:16207219,PMID:16283883,PMID:21398519,PMID:21682854,PMID:22240481,PMID:22763723,PMID:23333878,PMID:23518715,PMID:8298641,PMID:9482578,PMID:9887381
ATP7B	P35670	1020	1081	1070	1070	Natural variant	ID=VAR_076705;Note=In WD%3B unknown pathological significance. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs1423701688,PMID:23518715
ATP7B	P35670	1020	1081	1074	1074	Natural variant	ID=VAR_076706;Note=In WD%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs1206016866,PMID:23518715
ATP7B	P35670	1137	1185	1140	1140	Natural variant	ID=VAR_000765;Note=Polymorphism%3B no effect on copper transport activity. V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10721669,ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:14966923,ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:15952988,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:17823867,ECO:0000269|PubMed:18203200,ECO:0000269|PubMed:18373411,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:24303094,ECO:0000269|PubMed:9482578,ECO:0000269|PubMed:9554743,ECO:0000269|PubMed:9887381,ECO:0000269|Ref.2,ECO:0000269|Ref.9;Dbxref=dbSNP:rs1801249,PMID:10721669,PMID:10790207,PMID:11405812,PMID:14966923,PMID:14986826,PMID:15952988,PMID:15967699,PMID:17823867,PMID:18203200,PMID:18373411,PMID:23333878,PMID:24303094,PMID:9482578,PMID:9554743,PMID:9887381
ATP7B	P35670	1137	1185	1142	1142	Natural variant	ID=VAR_000766;Note=In WD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11405812;Dbxref=dbSNP:rs778749563,PMID:11405812
ATP7B	P35670	1137	1185	1143	1143	Natural variant	ID=VAR_023033;Note=T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14986826;Dbxref=dbSNP:rs587783313,PMID:14986826
ATP7B	P35670	1137	1185	1146	1146	Natural variant	ID=VAR_000767;Note=In WD. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9671269;Dbxref=PMID:9671269
ATP7B	P35670	1137	1185	1148	1148	Natural variant	ID=VAR_000768;Note=In WD%3B yeast complementation assays show that the variant mildly rescue iron-uptake deficiency of yeast mutant ccc2. I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10447265,ECO:0000269|PubMed:11216666,ECO:0000269|PubMed:14986826,ECO:0000269|PubMed:15845031,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:20333758,ECO:0000269|PubMed:21645214;Dbxref=dbSNP:rs60431989,PMID:10447265,PMID:11216666,PMID:14986826,PMID:15845031,PMID:15967699,PMID:20333758,PMID:21645214
ATP7B	P35670	1137	1185	1149	1149	Natural variant	ID=VAR_058930;Note=In WD. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18373411;Dbxref=PMID:18373411
ATP7B	P35670	1137	1185	1149	1149	Natural variant	ID=VAR_077618;Note=In WD%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25704634;Dbxref=PMID:25704634
ATP7B	P35670	1137	1185	1151	1151	Natural variant	ID=VAR_075338;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17949296,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:23235335,ECO:0000269|PubMed:23333878;Dbxref=dbSNP:rs755554442,PMID:17949296,PMID:21645214,PMID:23235335,PMID:23333878
ATP7B	P35670	1137	1185	1151	1151	Natural variant	ID=VAR_009022;Note=In WD. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10544227;Dbxref=dbSNP:rs377297166,PMID:10544227
ATP7B	P35670	1137	1185	1153	1153	Natural variant	ID=VAR_000769;Note=In WD. W->C;Dbxref=dbSNP:rs1330620114
ATP7B	P35670	1137	1185	1153	1153	Natural variant	ID=VAR_010018;Note=In WD. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8938442;Dbxref=PMID:8938442
ATP7B	P35670	1137	1185	1164	1164	Natural variant	ID=VAR_058931;Note=In WD. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18373411;Dbxref=dbSNP:rs867107727,PMID:18373411
ATP7B	P35670	1137	1185	1168	1168	Natural variant	ID=VAR_023034;Note=In WD. A->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12544487,ECO:0000269|PubMed:21645214;Dbxref=dbSNP:rs777879359,PMID:12544487,PMID:21645214
ATP7B	P35670	1137	1185	1169	1169	Natural variant	ID=VAR_009023;Note=In WD. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10544227;Dbxref=PMID:10544227
ATP7B	P35670	1137	1185	1169	1169	Natural variant	ID=VAR_000770;Note=In WD%3B moderate impairment in copper transport. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18203200;Dbxref=dbSNP:rs749085322,PMID:18203200
ATP7B	P35670	1137	1185	1173	1173	Natural variant	ID=VAR_058932;Note=In WD%3B yeast complementation assays show that the variant fully rescue iron-uptake deficiency of yeast mutant ccc2. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18373411,ECO:0000269|PubMed:20333758;Dbxref=PMID:18373411,PMID:20333758
ATP7B	P35670	1137	1185	1173	1173	Natural variant	ID=VAR_009024;Note=In WD. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544227,ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:14986826;Dbxref=dbSNP:rs756029120,PMID:10544227,PMID:11405812,PMID:14986826
ATP7B	P35670	1137	1185	1176	1176	Natural variant	ID=VAR_044478;Note=In WD%3B yeast complementation assays show that the variant mildly rescue iron-uptake deficiency of yeast mutant ccc2. G->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16088907,ECO:0000269|PubMed:20333758;Dbxref=PMID:16088907,PMID:20333758
ATP7B	P35670	1137	1185	1176	1176	Natural variant	ID=VAR_010019;Note=In WD. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15845031,ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:9887381;Dbxref=dbSNP:rs137853279,PMID:15845031,PMID:15967699,PMID:9887381
ATP7B	P35670	1137	1185	1178	1178	Natural variant	ID=VAR_076748;Note=In WD%3B unknown pathological significance. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17823867,ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs1387431334,PMID:17823867,PMID:23235335
ATP7B	P35670	1137	1185	1183	1183	Natural variant	ID=VAR_000771;Note=In WD. A->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12325021,ECO:0000269|PubMed:9671269;Dbxref=dbSNP:rs587783315,PMID:12325021,PMID:9671269
ATP7B	P35670	1137	1185	1183	1183	Natural variant	ID=VAR_000772;Note=In WD%3B unknown pathological significance%3B no effect on copper transport activity. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18203200,ECO:0000269|PubMed:9671269;Dbxref=PMID:18203200,PMID:9671269
ATP7B	P35670	1233	1301	1239	1239	Natural variant	ID=VAR_009026;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333758;Dbxref=dbSNP:rs374628199,PMID:20333758
ATP7B	P35670	1233	1301	1243	1243	Natural variant	ID=VAR_075339;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23333878;Dbxref=dbSNP:rs1277243795,PMID:23333878
ATP7B	P35670	1233	1301	1245	1245	Natural variant	ID=VAR_023036;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14986826;Dbxref=dbSNP:rs587783316,PMID:14986826
ATP7B	P35670	1233	1301	1245	1245	Natural variant	ID=VAR_075340;Note=In WD. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23333878;Dbxref=PMID:23333878
ATP7B	P35670	1233	1301	1248	1248	Natural variant	ID=VAR_023037;Note=In WD. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14986826;Dbxref=PMID:14986826
ATP7B	P35670	1233	1301	1250	1250	Natural variant	ID=VAR_076707;Note=In WD%3B unknown pathological significance. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs372042739,PMID:23518715
ATP7B	P35670	1233	1301	1252	1252	Natural variant	ID=VAR_044482;Note=In WD. V->I
ATP7B	P35670	1233	1301	1255	1255	Natural variant	ID=VAR_023038;Note=In WD. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12544487;Dbxref=PMID:12544487
ATP7B	P35670	1233	1301	1256	1256	Natural variant	ID=VAR_044483;Note=In WD. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15811015;Dbxref=PMID:15811015
ATP7B	P35670	1233	1301	1262	1262	Natural variant	ID=VAR_009027;Note=In WD. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10544227;Dbxref=dbSNP:rs769484789,PMID:10544227
ATP7B	P35670	1233	1301	1266	1266	Natural variant	ID=VAR_076750;Note=In WD%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23235335;Dbxref=PMID:23235335
ATP7B	P35670	1233	1301	1266	1266	Natural variant	ID=VAR_009028;Note=In WD%3B common mutation. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11243728,ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs121907992,PMID:11243728,PMID:23518715
ATP7B	P35670	1233	1301	1266	1266	Natural variant	ID=VAR_000781;Note=In WD%3B decreased copper transport activity%3B loss of ATPase activity. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22240481;Dbxref=PMID:22240481
ATP7B	P35670	1233	1301	1267	1267	Natural variant	ID=VAR_000782;Note=In WD. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:12544487,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:9452121;Dbxref=PMID:10790207,PMID:12544487,PMID:21645214,PMID:9452121
ATP7B	P35670	1233	1301	1267	1267	Natural variant	ID=VAR_058935;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. D->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18373411,ECO:0000269|PubMed:20333758;Dbxref=PMID:18373411,PMID:20333758
ATP7B	P35670	1233	1301	1268	1268	Natural variant	ID=VAR_076751;Note=In WD%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16649058;Dbxref=dbSNP:rs1314712150,PMID:16649058
ATP7B	P35670	1233	1301	1270	1270	Natural variant	ID=VAR_000783;Note=In WD%3B loss of copper transport activity%3B increased ATPase activity%3B does not affect localization to late endosomes. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10790207,ECO:0000269|PubMed:11231950,ECO:0000269|PubMed:11405812,ECO:0000269|PubMed:11690702,ECO:0000269|PubMed:12544487,ECO:0000269|PubMed:16207219,ECO:0000269|PubMed:16649058,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:23235335,ECO:0000269|PubMed:23333878,ECO:0000269|PubMed:23518715,ECO:0000269|PubMed:25982861,ECO:0000269|PubMed:8298641,ECO:0000269|PubMed:8533760,ECO:0000269|PubMed:9452121;Dbxref=dbSNP:rs121907990,PMID:10790207,PMID:11231950,PMID:11405812,PMID:11690702,PMID:12544487,PMID:16207219,PMID:16649058,PMID:21645214,PMID:22240481,PMID:23235335,PMID:23333878,PMID:23518715,PMID:25982861,PMID:8298641,PMID:8533760,PMID:9452121
ATP7B	P35670	1233	1301	1271	1271	Natural variant	ID=VAR_023039;Note=In WD. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15967699;Dbxref=PMID:15967699
ATP7B	P35670	1233	1301	1273	1273	Natural variant	ID=VAR_000784;Note=In WD%3B decreased copper transport activity%3B increased ATPase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15967699,ECO:0000269|PubMed:16283883,ECO:0000269|PubMed:21645214,ECO:0000269|PubMed:21682854,ECO:0000269|PubMed:22240481,ECO:0000269|PubMed:23235335;Dbxref=dbSNP:rs758355520,PMID:15967699,PMID:16283883,PMID:21645214,PMID:21682854,PMID:22240481,PMID:23235335
ATP7B	P35670	1233	1301	1278	1278	Natural variant	ID=VAR_000785;Note=In WD%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9222767;Dbxref=PMID:9222767
ATP7B	P35670	1233	1301	1279	1279	Natural variant	ID=VAR_023040;Note=In WD. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11043508;Dbxref=dbSNP:rs778914828,PMID:11043508
ATP7B	P35670	1233	1301	1279	1279	Natural variant	ID=VAR_044484;Note=In WD. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16207219;Dbxref=PMID:16207219
ATP7B	P35670	1233	1301	1281	1281	Natural variant	ID=VAR_076818;Note=In WD%3B unknown pathological significance. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22484412;Dbxref=PMID:22484412
ATP7B	P35670	1233	1301	1285	1292	Natural variant	ID=VAR_000786;Note=In WD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9222767;Dbxref=PMID:9222767
ATP7B	P35670	1233	1301	1287	1287	Natural variant	ID=VAR_044485;Note=In WD%3B yeast complementation assays show that the variant mildly rescue iron-uptake deficiency of yeast mutant ccc2. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16088907,ECO:0000269|PubMed:20333758;Dbxref=dbSNP:rs762866453,PMID:16088907,PMID:20333758
ATP7B	P35670	1233	1301	1288	1288	Natural variant	ID=VAR_076772;Note=In WD%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17949296;Dbxref=dbSNP:rs373748155,PMID:17949296
ATP7B	P35670	1233	1301	1293	1293	Natural variant	ID=VAR_076819;Note=In WD%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22484412,ECO:0000269|PubMed:25982861;Dbxref=dbSNP:rs776300396,PMID:22484412,PMID:25982861
ATP7B	P35670	1233	1301	1295	1295	Natural variant	ID=VAR_076752;Note=In WD%3B yeast complementation assays show that the variant does not rescue iron-uptake deficiency of yeast mutant ccc2. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21645214;Dbxref=PMID:21645214
ATP7B	P35670	1233	1301	1296	1296	Natural variant	ID=VAR_044486;Note=In WD. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11954751;Dbxref=dbSNP:rs199821556,PMID:11954751
ATP7B	P35670	1233	1301	1297	1297	Natural variant	ID=VAR_009029;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10544227;Dbxref=dbSNP:rs148399850,PMID:10544227
ATP7B	P35670	1233	1301	1297	1297	Natural variant	ID=VAR_044487;Note=In WD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10721669;Dbxref=PMID:10721669
ATP7B	P35670	1233	1301	1298	1298	Natural variant	ID=VAR_076708;Note=In WD%3B unknown pathological significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=dbSNP:rs753044473,PMID:23518715
ATP7B	P35670	1233	1301	1298	1298	Natural variant	ID=VAR_076709;Note=In WD%3B unknown pathological significance. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23518715;Dbxref=PMID:23518715
ATP7B	P35670	1020	1081	1027	1027	Mutagenesis	Note=Loss of copper transport activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22240481;Dbxref=PMID:22240481
ATP7B	P35670	1020	1081	1031	1031	Mutagenesis	Note=Decreased copper transport activity with no effect on ATPase activity. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22240481;Dbxref=PMID:22240481
ATP7B	P35670	1020	1081	1069	1069	Mutagenesis	Note=Loss of ATPase activity. Cannot form an acylphosphate intermediate during catalysis. Does not alter folding of the nucleotide-binding domain. H->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12551905;Dbxref=PMID:12551905
ATP7B	P35670	707	785	767	767	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP7B	P35670	1020	1081	1039	1044	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1020	1081	1048	1050	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1020	1081	1053	1064	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1020	1081	1072	1083	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1137	1185	1143	1149	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1137	1185	1151	1158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1137	1185	1163	1173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1137	1185	1174	1176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATP7B	P35670	1137	1185	1177	1184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ARF
ATG2A	Q2TAZ0	1809	1860	1	1938	Chain	ID=PRO_0000315234;Note=Autophagy-related protein 2 homolog A
ATG2A	Q2TAZ0	1557	1591	1	1938	Chain	ID=PRO_0000315234;Note=Autophagy-related protein 2 homolog A
ATG2A	Q2TAZ0	1204	1259	1	1938	Chain	ID=PRO_0000315234;Note=Autophagy-related protein 2 homolog A
ATG2A	Q2TAZ0	1557	1591	1	1607	Alternative sequence	ID=VSP_030510;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG2A	Q2TAZ0	1204	1259	1	1607	Alternative sequence	ID=VSP_030510;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG2A	Q2TAZ0	1809	1860	122	1938	Alternative sequence	ID=VSP_030512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG2A	Q2TAZ0	1557	1591	122	1938	Alternative sequence	ID=VSP_030512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG2A	Q2TAZ0	1204	1259	122	1938	Alternative sequence	ID=VSP_030512;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG2A	Q2TAZ0	1204	1259	1259	1259	Alternative sequence	ID=VSP_030515;Note=In isoform 2. K->KVQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACVR2A	P27037	176	224	20	513	Chain	ID=PRO_0000024398;Note=Activin receptor type-2A
ACVR2A	P27037	176	224	20	513	Chain	ID=PRO_0000024398;Note=Activin receptor type-2A
ACVR2A	P27037	176	224	162	513	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR2A	P27037	176	224	162	513	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACVR2A	P27037	176	224	192	485	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR2A	P27037	176	224	192	485	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR2A	P27037	176	224	198	206	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR2A	P27037	176	224	198	206	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR2A	P27037	176	224	219	219	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR2A	P27037	176	224	219	219	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ACVR2A	P27037	176	224	204	206	Sequence conflict	Note=GCV->PSL;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACVR2A	P27037	176	224	204	206	Sequence conflict	Note=GCV->PSL;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACVR2A	P27037	176	224	191	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	191	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	205	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	205	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	214	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	214	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	223	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ACVR2A	P27037	176	224	223	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SOC
ADAMTS18	Q8TE60	1063	1134	285	1221	Chain	ID=PRO_0000042163;Note=A disintegrin and metalloproteinase with thrombospondin motifs 18
ADAMTS18	Q8TE60	1063	1134	1052	1116	Domain	Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTS18	Q8TE60	1063	1134	1123	1178	Domain	Note=TSP type-1 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTS18	Q8TE60	1063	1134	1064	1082	Alternative sequence	ID=VSP_015776;Note=In isoform 2. CSATCGLGVRKREMKCSEK->VWIRSHCWVRRLRPSWLTQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11867212;Dbxref=PMID:11867212
ADAMTS18	Q8TE60	1063	1134	1083	1221	Alternative sequence	ID=VSP_015777;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11867212;Dbxref=PMID:11867212
ADAMTS18	Q8TE60	1063	1134	1080	1080	Natural variant	ID=VAR_057085;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs35478105,PMID:14702039
ASXL2	Q76L83	210	258	1	1435	Chain	ID=PRO_0000313826;Note=Putative Polycomb group protein ASXL2
ASXL2	Q76L83	210	258	95	235	Compositional bias	Note=Ser-rich
ASXL2	Q76L83	210	258	1	260	Alternative sequence	ID=VSP_030163;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATP10D	Q9P241	97	161	1	1426	Chain	ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD
ATP10D	Q9P241	545	608	1	1426	Chain	ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD
ATP10D	Q9P241	1189	1216	1	1426	Chain	ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD
ATP10D	Q9P241	97	161	1	97	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	97	161	98	118	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	97	161	119	121	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	97	161	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	97	161	143	321	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	545	608	387	1113	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	1189	1216	1167	1195	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	1189	1216	1196	1216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10D	Q9P241	545	608	553	747	Alternative sequence	ID=VSP_006954;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP10D	Q9P241	97	161	142	142	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATG10	Q9H0Y0	36	72	1	220	Chain	ID=PRO_0000096183;Note=Ubiquitin-like-conjugating enzyme ATG10
ATG10	Q9H0Y0	36	72	1	220	Chain	ID=PRO_0000096183;Note=Ubiquitin-like-conjugating enzyme ATG10
ATG10	Q9H0Y0	36	72	62	62	Natural variant	ID=VAR_024370;Note=S->P;Dbxref=dbSNP:rs3734114
ATG10	Q9H0Y0	36	72	62	62	Natural variant	ID=VAR_024370;Note=S->P;Dbxref=dbSNP:rs3734114
ATF1	P18846	109	170	1	271	Chain	ID=PRO_0000076575;Note=Cyclic AMP-dependent transcription factor ATF-1
ATF1	P18846	109	170	110	110	Site	Note=Breakpoint for translocation to form chimeric EWSR1/ATF1 protein
ATF1	P18846	109	170	112	112	Site	Note=Breakpoint for translocation to form chimeric FUS/ATF1 protein
ATF1	P18846	109	170	1	135	Alternative sequence	ID=VSP_055559;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATCAY	Q86WG3	260	288	1	371	Chain	ID=PRO_0000210767;Note=Caytaxin
ATCAY	Q86WG3	289	321	1	371	Chain	ID=PRO_0000210767;Note=Caytaxin
ATCAY	Q86WG3	322	333	1	371	Chain	ID=PRO_0000210767;Note=Caytaxin
ATCAY	Q86WG3	358	368	1	371	Chain	ID=PRO_0000210767;Note=Caytaxin
ATCAY	Q86WG3	260	288	171	328	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
ATCAY	Q86WG3	289	321	171	328	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
ATCAY	Q86WG3	322	333	171	328	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
ATCAY	Q86WG3	260	288	190	371	Region	Note=Mediates interaction with GLS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16899818;Dbxref=PMID:16899818
ATCAY	Q86WG3	289	321	190	371	Region	Note=Mediates interaction with GLS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16899818;Dbxref=PMID:16899818
ATCAY	Q86WG3	322	333	190	371	Region	Note=Mediates interaction with GLS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16899818;Dbxref=PMID:16899818
ATCAY	Q86WG3	358	368	190	371	Region	Note=Mediates interaction with GLS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16899818;Dbxref=PMID:16899818
ATCAY	Q86WG3	289	321	301	301	Natural variant	ID=VAR_017164;Note=In ATCAY. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14556008;Dbxref=PMID:14556008
ATAD2B	Q9ULI0	1131	1359	1	1458	Chain	ID=PRO_0000050789;Note=ATPase family AAA domain-containing protein 2B
ATAD2B	Q9ULI0	1044	1085	1	1458	Chain	ID=PRO_0000050789;Note=ATPase family AAA domain-containing protein 2B
ATAD2B	Q9ULI0	1044	1085	975	1045	Domain	Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035
ATAD2B	Q9ULI0	1131	1359	1247	1250	Compositional bias	Note=Poly-Ser
ATAD2B	Q9ULI0	1131	1359	1338	1338	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
ATAD2B	Q9ULI0	1131	1359	1347	1347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
ATAD2B	Q9ULI0	1044	1085	1043	1066	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXJ
ATAD2B	Q9ULI0	1044	1085	1069	1083	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXJ
ATL3	Q6DD88	326	345	1	541	Chain	ID=PRO_0000287109;Note=Atlastin-3
ATL3	Q6DD88	187	206	1	541	Chain	ID=PRO_0000287109;Note=Atlastin-3
ATL3	Q6DD88	170	187	1	541	Chain	ID=PRO_0000287109;Note=Atlastin-3
ATL3	Q6DD88	326	345	1	445	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270207;Dbxref=PMID:18270207
ATL3	Q6DD88	187	206	1	445	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270207;Dbxref=PMID:18270207
ATL3	Q6DD88	170	187	1	445	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18270207;Dbxref=PMID:18270207
ATL3	Q6DD88	187	206	57	305	Domain	Note=GB1/RHD3-type G
ATL3	Q6DD88	170	187	57	305	Domain	Note=GB1/RHD3-type G
ATL3	Q6DD88	187	206	192	192	Natural variant	ID=VAR_070973;Note=In HSN1F%3B causes mislocalization of the protein%3B the mutant protein accumulates in condensed structures near the nucleus and localizes to unbranched tubules%3B has a dominant-negative disruptive effect on the regular structure of the endoplasmic reticulum. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24459106;Dbxref=dbSNP:rs587777108,PMID:24459106
ATL3	Q6DD88	170	187	173	173	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATL3	Q6DD88	187	206	202	202	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATL3	Q6DD88	170	187	168	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	170	187	180	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	187	206	187	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	170	187	187	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	187	206	204	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	326	345	318	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	326	345	334	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATL3	Q6DD88	326	345	340	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VGR
ATAD2	Q6PL18	1334	1377	1	1390	Chain	ID=PRO_0000084796;Note=ATPase family AAA domain-containing protein 2
ATAD2	Q6PL18	1159	1289	1	1390	Chain	ID=PRO_0000084796;Note=ATPase family AAA domain-containing protein 2
ATAD2	Q6PL18	632	737	1	1390	Chain	ID=PRO_0000084796;Note=ATPase family AAA domain-containing protein 2
ATAD2	Q6PL18	1159	1289	1176	1176	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATAD2	Q6PL18	1159	1289	1200	1200	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
ATAD2	Q6PL18	1159	1289	1233	1233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATAD2	Q6PL18	1159	1289	1235	1235	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATAD2	Q6PL18	1159	1289	1243	1243	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATAD2	Q6PL18	1159	1289	1236	1236	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ATAD2	Q6PL18	1334	1377	583	1390	Alternative sequence	ID=VSP_015635;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ATAD2	Q6PL18	1159	1289	583	1390	Alternative sequence	ID=VSP_015635;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ATAD2	Q6PL18	632	737	583	1390	Alternative sequence	ID=VSP_015635;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ATAD2	Q6PL18	1159	1289	1280	1280	Natural variant	ID=VAR_047625;Note=I->T;Dbxref=dbSNP:rs3758122
ADAMTSL3	P82987	121	200	27	1691	Chain	ID=PRO_0000249684;Note=ADAMTS-like protein 3
ADAMTSL3	P82987	242	267	27	1691	Chain	ID=PRO_0000249684;Note=ADAMTS-like protein 3
ADAMTSL3	P82987	1324	1385	27	1691	Chain	ID=PRO_0000249684;Note=ADAMTS-like protein 3
ADAMTSL3	P82987	1385	1424	27	1691	Chain	ID=PRO_0000249684;Note=ADAMTS-like protein 3
ADAMTSL3	P82987	121	200	75	124	Domain	Note=TSP type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTSL3	P82987	1324	1385	1296	1378	Domain	Note=Ig-like C2-type 3
ADAMTSL3	P82987	1385	1424	1424	1482	Domain	Note=TSP type-1 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
ADAMTSL3	P82987	1324	1385	1330	1330	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTSL3	P82987	1324	1385	1343	1343	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTSL3	P82987	1324	1385	1349	1349	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTSL3	P82987	1324	1385	1356	1356	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAMTSL3	P82987	121	200	91	123	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTSL3	P82987	1324	1385	1321	1367	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAMTSL3	P82987	121	200	146	146	Natural variant	ID=VAR_027478;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs4483821,PMID:15489334
ADAMTSL3	P82987	1324	1385	1370	1370	Natural variant	ID=VAR_027483;Note=T->A;Dbxref=dbSNP:rs17158450
ADAMTSL3	P82987	242	267	265	265	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYB5B	O43169	97	107	12	146	Chain	ID=PRO_0000006472;Note=Cytochrome b5 type B
CYB5B	O43169	97	107	97	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NER
ASH2L	Q9UBL3	195	227	1	628	Chain	ID=PRO_0000064697;Note=Set1/Ash2 histone methyltransferase complex subunit ASH2
ASH2L	Q9UBL3	509	540	1	628	Chain	ID=PRO_0000064697;Note=Set1/Ash2 histone methyltransferase complex subunit ASH2
ASH2L	Q9UBL3	540	573	1	628	Chain	ID=PRO_0000064697;Note=Set1/Ash2 histone methyltransferase complex subunit ASH2
ASH2L	Q9UBL3	509	540	360	583	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
ASH2L	Q9UBL3	540	573	360	583	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
ASH2L	Q9UBL3	540	573	541	573	Alternative sequence	ID=VSP_007578;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11466562;Dbxref=PMID:11466562
ASH2L	Q9UBL3	195	227	212	212	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASH2L	Q9UBL3	195	227	217	217	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASH2L	Q9UBL3	195	227	193	196	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RSN
ASH2L	Q9UBL3	195	227	197	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RSN
ASH2L	Q9UBL3	195	227	205	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RSN
ASH2L	Q9UBL3	195	227	219	221	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RSN
ASH2L	Q9UBL3	195	227	223	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RSN
ASH2L	Q9UBL3	509	540	540	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6L
ASH2L	Q9UBL3	540	573	540	545	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6L
ASH2L	Q9UBL3	540	573	548	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6L
ASH2L	Q9UBL3	540	573	562	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6L
ASH2L	Q9UBL3	540	573	573	577	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6L
ASRGL1	Q7L266	203	240	168	308	Chain	ID=PRO_0000420556;Note=Isoaspartyl peptidase/L-asparaginase beta chain
ASRGL1	Q7L266	203	240	168	308	Chain	ID=PRO_0000420556;Note=Isoaspartyl peptidase/L-asparaginase beta chain
ASRGL1	Q7L266	203	240	219	222	Region	Note=Substrate binding
ASRGL1	Q7L266	203	240	219	222	Region	Note=Substrate binding
ASRGL1	Q7L266	203	240	203	205	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	203	205	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	206	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	206	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	211	213	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	211	213	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	222	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	222	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	230	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASRGL1	Q7L266	203	240	230	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4O0C
ASNA1	O43681	203	239	2	348	Chain	ID=PRO_0000152253;Note=ATPase ASNA1
ASNA1	O43681	203	239	2	348	Chain	ID=PRO_0000152253;Note=ATPase ASNA1
ASNA1	O43681	203	239	205	205	Sequence conflict	Note=C->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASNA1	O43681	203	239	205	205	Sequence conflict	Note=C->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP12A	P54707	76	144	1	1039	Chain	ID=PRO_0000046260;Note=Potassium-transporting ATPase alpha chain 2
ATP12A	P54707	76	144	1	102	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP12A	P54707	76	144	103	123	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP12A	P54707	76	144	124	146	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ASZ1	Q8WWH4	68	109	1	475	Chain	ID=PRO_0000066969;Note=Ankyrin repeat%2C SAM and basic leucine zipper domain-containing protein 1
ASZ1	Q8WWH4	68	109	45	74	Repeat	Note=ANK 1;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASZ1	Q8WWH4	68	109	78	107	Repeat	Note=ANK 2;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP10B	O94823	1188	1215	1	1461	Chain	ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB
ATP10B	O94823	1121	1188	1	1461	Chain	ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB
ATP10B	O94823	540	604	1	1461	Chain	ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB
ATP10B	O94823	289	333	1	1461	Chain	ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB
ATP10B	O94823	289	333	133	316	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	289	333	317	338	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	540	604	391	1111	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1121	1188	1112	1132	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1121	1188	1133	1144	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1121	1188	1145	1164	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1188	1215	1165	1194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1121	1188	1165	1194	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1188	1215	1195	1216	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP10B	O94823	1188	1215	530	1461	Alternative sequence	ID=VSP_007307;Note=In isoform B and isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP10B	O94823	1121	1188	530	1461	Alternative sequence	ID=VSP_007307;Note=In isoform B and isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP10B	O94823	540	604	530	1461	Alternative sequence	ID=VSP_007307;Note=In isoform B and isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ETNPPL	Q8TBG4	361	390	1	499	Chain	ID=PRO_0000287663;Note=Ethanolamine-phosphate phospho-lyase
ETNPPL	Q8TBG4	112	136	1	499	Chain	ID=PRO_0000287663;Note=Ethanolamine-phosphate phospho-lyase
ATP2A2	P16615	73	108	1	1042	Chain	ID=PRO_0000046196;Note=Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
ATP2A2	P16615	154	181	1	1042	Chain	ID=PRO_0000046196;Note=Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
ATP2A2	P16615	514	587	1	1042	Chain	ID=PRO_0000046196;Note=Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
ATP2A2	P16615	73	108	70	89	Topological domain	Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2A2	P16615	73	108	90	110	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2A2	P16615	154	181	111	253	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2A2	P16615	514	587	314	756	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2A2	P16615	514	587	575	594	Region	Note=Interaction with HAX1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18971376;Dbxref=PMID:18971376
ATP2A2	P16615	514	587	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O55143
ATP2A2	P16615	514	587	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ATP2A2	P16615	154	181	155	181	Alternative sequence	ID=VSP_039392;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATP2A2	P16615	73	108	74	108	Natural variant	ID=VAR_079685;Note=In DD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28035777;Dbxref=PMID:28035777
ATP2A2	P16615	73	108	101	101	Natural variant	ID=VAR_079686;Note=In DD. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28035777;Dbxref=PMID:28035777
ATP2A2	P16615	154	181	160	160	Natural variant	ID=VAR_008613;Note=In DD. P->L
ATP2A2	P16615	514	587	560	560	Natural variant	ID=VAR_008623;Note=In DD%3B neuropsychiatric phenotype. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10441325;Dbxref=dbSNP:rs121912734,PMID:10441325
ATM	Q13315	110	165	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	792	822	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	1537	1592	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	2543	2596	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	2861	2890	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	110	165	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	792	822	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	1537	1592	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	2543	2596	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	2861	2890	2	3056	Chain	ID=PRO_0000088840;Note=Serine-protein kinase ATM
ATM	Q13315	2543	2596	1960	2566	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
ATM	Q13315	2543	2596	1960	2566	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
ATM	Q13315	2861	2890	2712	2962	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
ATM	Q13315	2861	2890	2712	2962	Domain	Note=PI3K/PI4K;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269
ATM	Q13315	110	165	126	126	Natural variant	ID=VAR_010799;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:9711876;Dbxref=dbSNP:rs2234997,PMID:17344846,PMID:9711876
ATM	Q13315	110	165	126	126	Natural variant	ID=VAR_010799;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:9711876;Dbxref=dbSNP:rs2234997,PMID:17344846,PMID:9711876
ATM	Q13315	110	165	140	140	Natural variant	ID=VAR_041546;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55633650,PMID:17344846
ATM	Q13315	110	165	140	140	Natural variant	ID=VAR_041546;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55633650,PMID:17344846
ATM	Q13315	792	822	814	814	Natural variant	ID=VAR_056681;Note=D->E;Dbxref=dbSNP:rs3218695
ATM	Q13315	792	822	814	814	Natural variant	ID=VAR_056681;Note=D->E;Dbxref=dbSNP:rs3218695
ATM	Q13315	1537	1592	1541	1541	Natural variant	ID=VAR_056686;Note=L->F;Dbxref=dbSNP:rs3092849
ATM	Q13315	1537	1592	1541	1541	Natural variant	ID=VAR_056686;Note=L->F;Dbxref=dbSNP:rs3092849
ATM	Q13315	1537	1592	1566	1566	Natural variant	ID=VAR_010827;Note=In AT. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9792409;Dbxref=PMID:9792409
ATM	Q13315	1537	1592	1566	1566	Natural variant	ID=VAR_010827;Note=In AT. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9792409;Dbxref=PMID:9792409
ATM	Q13315	1537	1592	1570	1570	Natural variant	ID=VAR_010828;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10534763;Dbxref=dbSNP:rs140856217,PMID:10534763
ATM	Q13315	1537	1592	1570	1570	Natural variant	ID=VAR_010828;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10534763;Dbxref=dbSNP:rs140856217,PMID:10534763
ATM	Q13315	2543	2596	2546	2548	Natural variant	ID=VAR_010861;Note=In AT%3B also found in T-prolymphocytic leukemia and T-cell acute lymphoblastic leukemia%3B lack of phosphorylation of target proteins. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10817650,ECO:0000269|PubMed:19431188,ECO:0000269|PubMed:7792600,ECO:0000269|PubMed:8755918,ECO:0000269|PubMed:8789452,ECO:0000269|PubMed:8797579,ECO:0000269|PubMed:8808599,ECO:0000269|PubMed:8845835,ECO:0000269|PubMed:9150358,ECO:0000269|PubMed:9288106,ECO:0000269|PubMed:9463314;Dbxref=PMID:10817650,PMID:19431188,PMID:7792600,PMID:8755918,PMID:8789452,PMID:8797579,PMID:8808599,PMID:8845835,PMID:9150358,PMID:9288106,PMID:9463314
ATM	Q13315	2543	2596	2546	2548	Natural variant	ID=VAR_010861;Note=In AT%3B also found in T-prolymphocytic leukemia and T-cell acute lymphoblastic leukemia%3B lack of phosphorylation of target proteins. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10817650,ECO:0000269|PubMed:19431188,ECO:0000269|PubMed:7792600,ECO:0000269|PubMed:8755918,ECO:0000269|PubMed:8789452,ECO:0000269|PubMed:8797579,ECO:0000269|PubMed:8808599,ECO:0000269|PubMed:8845835,ECO:0000269|PubMed:9150358,ECO:0000269|PubMed:9288106,ECO:0000269|PubMed:9463314;Dbxref=PMID:10817650,PMID:19431188,PMID:7792600,PMID:8755918,PMID:8789452,PMID:8797579,PMID:8808599,PMID:8845835,PMID:9150358,PMID:9288106,PMID:9463314
ATM	Q13315	2543	2596	2554	2554	Natural variant	ID=VAR_010862;Note=In AT%3B lack of phosphorylation of target proteins. H->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19431188,ECO:0000269|PubMed:9463314;Dbxref=PMID:19431188,PMID:9463314
ATM	Q13315	2543	2596	2554	2554	Natural variant	ID=VAR_010862;Note=In AT%3B lack of phosphorylation of target proteins. H->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19431188,ECO:0000269|PubMed:9463314;Dbxref=PMID:19431188,PMID:9463314
ATM	Q13315	2543	2596	2570	2570	Natural variant	ID=VAR_056690;Note=E->G;Dbxref=dbSNP:rs28904920
ATM	Q13315	2543	2596	2570	2570	Natural variant	ID=VAR_056690;Note=E->G;Dbxref=dbSNP:rs28904920
ATM	Q13315	2861	2890	2867	2867	Natural variant	ID=VAR_010886;Note=In AT. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8698354,ECO:0000269|PubMed:9887333;Dbxref=PMID:8698354,PMID:9887333
ATM	Q13315	2861	2890	2867	2867	Natural variant	ID=VAR_010886;Note=In AT. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8698354,ECO:0000269|PubMed:9887333;Dbxref=PMID:8698354,PMID:9887333
ATM	Q13315	2861	2890	2870	2870	Natural variant	ID=VAR_041583;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55798854,PMID:17344846
ATM	Q13315	2861	2890	2870	2870	Natural variant	ID=VAR_041583;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55798854,PMID:17344846
ATM	Q13315	2861	2890	2871	2872	Natural variant	ID=VAR_010887;Note=In T-prolymphocytic leukemia. RH->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9288106;Dbxref=PMID:9288106
ATM	Q13315	2861	2890	2871	2872	Natural variant	ID=VAR_010887;Note=In T-prolymphocytic leukemia. RH->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9288106;Dbxref=PMID:9288106
ATM	Q13315	2861	2890	2890	2890	Natural variant	ID=VAR_010888;Note=In T-prolymphocytic leukemia. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9288106,ECO:0000269|PubMed:9488043;Dbxref=dbSNP:rs587779874,PMID:9288106,PMID:9488043
ATM	Q13315	2861	2890	2890	2890	Natural variant	ID=VAR_010888;Note=In T-prolymphocytic leukemia. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9288106,ECO:0000269|PubMed:9488043;Dbxref=dbSNP:rs587779874,PMID:9288106,PMID:9488043
ATM	Q13315	2861	2890	2870	2870	Mutagenesis	Note=Loss of kinase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9733515;Dbxref=PMID:9733515
ATM	Q13315	2861	2890	2870	2870	Mutagenesis	Note=Loss of kinase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9733515;Dbxref=PMID:9733515
ATM	Q13315	2861	2890	2875	2875	Mutagenesis	Note=Loss of kinase activity. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9733515;Dbxref=PMID:9733515
ATM	Q13315	2861	2890	2875	2875	Mutagenesis	Note=Loss of kinase activity. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9733515;Dbxref=PMID:9733515
ATG7	O95352	137	176	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	176	226	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	375	428	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	428	493	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	493	561	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	625	652	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	652	693	2	703	Chain	ID=PRO_0000212806;Note=Ubiquitin-like modifier-activating enzyme ATG7
ATG7	O95352	137	176	138	176	Alternative sequence	ID=VSP_045206;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG7	O95352	176	226	138	176	Alternative sequence	ID=VSP_045206;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG7	O95352	625	652	626	652	Alternative sequence	ID=VSP_013205;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG7	O95352	652	693	626	652	Alternative sequence	ID=VSP_013205;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATG7	O95352	652	693	653	693	Alternative sequence	ID=VSP_045207;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATG7	O95352	428	493	471	471	Natural variant	ID=VAR_053014;Note=V->A;Dbxref=dbSNP:rs36117895
ATG7	O95352	176	226	210	210	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP14	Q86UN6	87	147	1	197	Chain	ID=PRO_0000064521;Note=A-kinase anchor protein 14
AKAP14	Q86UN6	87	147	88	147	Alternative sequence	ID=VSP_009909;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12475942;Dbxref=PMID:12475942
AKAP14	Q86UN6	87	147	88	89	Alternative sequence	ID=VSP_009910;Note=In isoform 3. KC->VS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12475942;Dbxref=PMID:12475942
AKAP14	Q86UN6	87	147	90	197	Alternative sequence	ID=VSP_009911;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12475942;Dbxref=PMID:12475942
AKR1C4	P17516	123	149	1	323	Chain	ID=PRO_0000124640;Note=Aldo-keto reductase family 1 member C4
AKR1C4	P17516	123	149	1	323	Chain	ID=PRO_0000124640;Note=Aldo-keto reductase family 1 member C4
AKR1C4	P17516	123	149	135	135	Natural variant	ID=VAR_028240;Note=G->E;Dbxref=dbSNP:rs11253043
AKR1C4	P17516	123	149	135	135	Natural variant	ID=VAR_028240;Note=G->E;Dbxref=dbSNP:rs11253043
AKR1C4	P17516	123	149	145	145	Natural variant	ID=VAR_013290;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10634139;Dbxref=dbSNP:rs3829125,PMID:10634139
AKR1C4	P17516	123	149	145	145	Natural variant	ID=VAR_013290;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10634139;Dbxref=dbSNP:rs3829125,PMID:10634139
AKR1C4	P17516	123	149	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FVL
AKR1C4	P17516	123	149	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FVL
AKR1C4	P17516	123	149	144	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FVL
AKR1C4	P17516	123	149	144	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FVL
AKR1B1	P15121	143	184	2	316	Chain	ID=PRO_0000124623;Note=Aldose reductase
AKR1B1	P15121	117	143	2	316	Chain	ID=PRO_0000124623;Note=Aldose reductase
AKR1B1	P15121	78	117	2	316	Chain	ID=PRO_0000124623;Note=Aldose reductase
AKR1B1	P15121	78	117	111	111	Binding site	Note=Substrate
AKR1B1	P15121	78	117	78	78	Site	Note=Lowers pKa of active site Tyr
AKR1B1	P15121	78	117	95	95	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
AKR1B1	P15121	78	117	90	90	Natural variant	ID=VAR_048213;Note=K->E;Dbxref=dbSNP:rs2229542
AKR1B1	P15121	78	117	78	78	Mutagenesis	Note=Reduced enzymatic activity. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8245005;Dbxref=PMID:8245005
AKR1B1	P15121	78	117	111	111	Mutagenesis	Note=Reduced enzymatic activity. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8245005;Dbxref=PMID:8245005
AKR1B1	P15121	78	117	114	114	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1B1	P15121	117	143	117	117	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1B1	P15121	78	117	117	117	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1B1	P15121	117	143	142	142	Sequence conflict	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1B1	P15121	143	184	172	172	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1B1	P15121	78	117	74	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	78	117	81	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	78	117	86	88	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	78	117	89	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	78	117	105	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	117	143	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PDC
AKR1B1	P15121	117	143	127	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U2C
AKR1B1	P15121	143	184	138	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	117	143	138	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	143	184	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	143	184	157	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	143	184	164	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AKR1B1	P15121	143	184	181	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1US0
AMFR	Q9UKV5	505	533	1	643	Chain	ID=PRO_0000064579;Note=E3 ubiquitin-protein ligase AMFR
AMFR	Q9UKV5	325	361	1	643	Chain	ID=PRO_0000064579;Note=E3 ubiquitin-protein ligase AMFR
AMFR	Q9UKV5	171	222	1	643	Chain	ID=PRO_0000064579;Note=E3 ubiquitin-protein ligase AMFR
AMFR	Q9UKV5	116	171	1	643	Chain	ID=PRO_0000064579;Note=E3 ubiquitin-protein ligase AMFR
AMFR	Q9UKV5	116	171	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMFR	Q9UKV5	116	171	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMFR	Q9UKV5	171	222	186	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMFR	Q9UKV5	171	222	215	235	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMFR	Q9UKV5	325	361	341	379	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
AMFR	Q9UKV5	505	533	516	516	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
AMFR	Q9UKV5	505	533	523	523	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
AMFR	Q9UKV5	325	361	341	344	Mutagenesis	Note=Decreased palmitoylation. CAIC->AAIA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22728137;Dbxref=PMID:22728137
AMFR	Q9UKV5	325	361	356	356	Mutagenesis	Note=Decreased palmitoylation. No degradation of HMGCR. C->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16168377,ECO:0000269|PubMed:22728137;Dbxref=PMID:16168377,PMID:22728137
AMFR	Q9UKV5	325	361	332	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXH
AMFR	Q9UKV5	325	361	342	344	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LAD
AMFR	Q9UKV5	325	361	351	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LAD
AMFR	Q9UKV5	325	361	355	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXH
AMFR	Q9UKV5	325	361	359	361	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LAD
ANXA6	P08133	613	654	2	673	Chain	ID=PRO_0000067494;Note=Annexin A6
ANXA6	P08133	561	593	2	673	Chain	ID=PRO_0000067494;Note=Annexin A6
ANXA6	P08133	411	449	2	673	Chain	ID=PRO_0000067494;Note=Annexin A6
ANXA6	P08133	411	449	372	432	Repeat	Note=Annexin 5
ANXA6	P08133	411	449	444	504	Repeat	Note=Annexin 6
ANXA6	P08133	561	593	533	593	Repeat	Note=Annexin 7
ANXA6	P08133	613	654	608	668	Repeat	Note=Annexin 8
ANXA6	P08133	411	449	418	418	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA6	P08133	411	449	422	422	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48037
ANXA6	P08133	613	654	620	620	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA6	P08133	613	654	619	619	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANXA6	P08133	411	449	413	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	411	449	424	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	411	449	436	448	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	411	449	449	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	561	593	556	568	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	561	593	569	572	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	561	593	574	581	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	561	593	584	611	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	613	654	613	616	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	613	654	619	628	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	613	654	630	633	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	613	654	634	645	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
ANXA6	P08133	613	654	649	656	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M9I
AP3M2	P53677	148	194	1	418	Chain	ID=PRO_0000193784;Note=AP-3 complex subunit mu-2
AP3M2	P53677	148	194	1	418	Chain	ID=PRO_0000193784;Note=AP-3 complex subunit mu-2
AP3M2	P53677	148	194	1	418	Chain	ID=PRO_0000193784;Note=AP-3 complex subunit mu-2
AP3M2	P53677	148	194	176	417	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP3M2	P53677	148	194	176	417	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP3M2	P53677	148	194	176	417	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP3S1	Q92572	91	115	1	193	Chain	ID=PRO_0000193815;Note=AP-3 complex subunit sigma-1
AP3S1	Q92572	115	151	1	193	Chain	ID=PRO_0000193815;Note=AP-3 complex subunit sigma-1
ANAPC5	Q9UJX4	480	505	1	755	Chain	ID=PRO_0000064597;Note=Anaphase-promoting complex subunit 5
ANAPC5	Q9UJX4	344	374	1	755	Chain	ID=PRO_0000064597;Note=Anaphase-promoting complex subunit 5
ANAPC5	Q9UJX4	219	253	1	755	Chain	ID=PRO_0000064597;Note=Anaphase-promoting complex subunit 5
ANAPC5	Q9UJX4	219	253	209	249	Repeat	Note=TPR 1
ANAPC5	Q9UJX4	219	253	250	300	Repeat	Note=TPR 2
ANAPC5	Q9UJX4	344	374	338	378	Repeat	Note=TPR 4
ANAPC5	Q9UJX4	480	505	467	500	Repeat	Note=TPR 7
ANAPC5	Q9UJX4	480	505	501	540	Repeat	Note=TPR 8
ANAPC5	Q9UJX4	219	253	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ANAPC5	Q9UJX4	480	505	341	755	Alternative sequence	ID=VSP_008469;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ANAPC5	Q9UJX4	344	374	341	755	Alternative sequence	ID=VSP_008469;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ANAPC5	Q9UJX4	219	253	209	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	219	253	227	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	219	253	233	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	219	253	252	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	344	374	337	350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	344	374	351	353	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	344	374	361	369	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	344	374	374	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	480	505	483	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC5	Q9UJX4	480	505	504	522	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
AP2A1	O95782	705	726	1	977	Chain	ID=PRO_0000193730;Note=AP-2 complex subunit alpha-1
AP2A1	O95782	907	952	1	977	Chain	ID=PRO_0000193730;Note=AP-2 complex subunit alpha-1
AP2A1	O95782	705	726	706	727	Alternative sequence	ID=VSP_000161;Note=In isoform B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334;Dbxref=PMID:11230166,PMID:15489334
AP2A1	O95782	907	952	924	977	Sequence conflict	Note=ENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCELLAQQF->GDREDTRVWGMPGTFLRPFVFLFLFICCCLHSGGLGGVPLPPFPPQAQRGEGPGKWMSPPLPPHPVVAPPTPSPSRGCVLL;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP3B2	Q13367	370	394	1	1082	Chain	ID=PRO_0000193748;Note=AP-3 complex subunit beta-2
AP3B2	Q13367	88	120	1	1082	Chain	ID=PRO_0000193748;Note=AP-3 complex subunit beta-2
AP3B2	Q13367	370	394	1	937	Alternative sequence	ID=VSP_043905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17453999;Dbxref=PMID:17453999
AP3B2	Q13367	88	120	1	937	Alternative sequence	ID=VSP_043905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17453999;Dbxref=PMID:17453999
AP3B2	Q13367	88	120	89	120	Alternative sequence	ID=VSP_054918;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AP1M2	Q9Y6Q5	349	391	1	423	Chain	ID=PRO_0000193772;Note=AP-1 complex subunit mu-2
AP1M2	Q9Y6Q5	296	349	1	423	Chain	ID=PRO_0000193772;Note=AP-1 complex subunit mu-2
AP1M2	Q9Y6Q5	272	296	1	423	Chain	ID=PRO_0000193772;Note=AP-1 complex subunit mu-2
AP1M2	Q9Y6Q5	349	391	168	421	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP1M2	Q9Y6Q5	296	349	168	421	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP1M2	Q9Y6Q5	272	296	168	421	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP1M2	Q9Y6Q5	349	391	364	364	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AQP4	P55087	204	231	1	323	Chain	ID=PRO_0000063948;Note=Aquaporin-4
AQP4	P55087	204	231	185	205	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP4	P55087	204	231	206	231	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP4	P55087	204	231	213	215	Motif	Note=NPA 2
AQP4	P55087	204	231	206	206	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP4	P55087	204	231	189	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD8
AQP4	P55087	204	231	214	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD8
AQP4	P55087	204	231	228	231	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD8
AQP9	O43315	79	125	1	295	Chain	ID=PRO_0000063964;Note=Aquaporin-9
AQP9	O43315	79	125	1	295	Chain	ID=PRO_0000063964;Note=Aquaporin-9
AQP9	O43315	79	125	76	110	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP9	O43315	79	125	76	110	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP9	O43315	79	125	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP9	O43315	79	125	111	131	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP9	O43315	79	125	84	86	Motif	Note=NPA 1
AQP9	O43315	79	125	84	86	Motif	Note=NPA 1
ARFGAP2	Q8N6H7	314	356	2	521	Chain	ID=PRO_0000278468;Note=ADP-ribosylation factor GTPase-activating protein 2
ARFGAP2	Q8N6H7	270	313	2	521	Chain	ID=PRO_0000278468;Note=ADP-ribosylation factor GTPase-activating protein 2
ARFGAP2	Q8N6H7	187	206	2	521	Chain	ID=PRO_0000278468;Note=ADP-ribosylation factor GTPase-activating protein 2
ARFGAP2	Q8N6H7	132	160	2	521	Chain	ID=PRO_0000278468;Note=ADP-ribosylation factor GTPase-activating protein 2
ARFGAP2	Q8N6H7	314	356	97	521	Region	Note=Required for interaction with coatomer
ARFGAP2	Q8N6H7	270	313	97	521	Region	Note=Required for interaction with coatomer
ARFGAP2	Q8N6H7	187	206	97	521	Region	Note=Required for interaction with coatomer
ARFGAP2	Q8N6H7	132	160	97	521	Region	Note=Required for interaction with coatomer
ARFGAP2	Q8N6H7	270	313	242	308	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARFGAP2	Q8N6H7	132	160	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ARFGAP2	Q8N6H7	132	160	146	146	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
ARFGAP2	Q8N6H7	187	206	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ARFGAP2	Q8N6H7	270	313	312	312	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARFGAP2	Q8N6H7	314	356	334	334	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ARFGAP2	Q8N6H7	314	356	340	340	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARFGAP2	Q8N6H7	187	206	1	269	Alternative sequence	ID=VSP_056054;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFGAP2	Q8N6H7	132	160	1	269	Alternative sequence	ID=VSP_056054;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFGAP2	Q8N6H7	132	160	133	160	Alternative sequence	ID=VSP_056056;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFGAP2	Q8N6H7	132	160	143	143	Natural variant	ID=VAR_048321;Note=P->R;Dbxref=dbSNP:rs11542793
ARFGAP2	Q8N6H7	314	356	339	339	Natural variant	ID=VAR_048322;Note=R->H;Dbxref=dbSNP:rs34662994
ARFGAP3	Q9NP61	355	398	1	516	Chain	ID=PRO_0000074193;Note=ADP-ribosylation factor GTPase-activating protein 3
ARFGAP3	Q9NP61	188	208	1	516	Chain	ID=PRO_0000074193;Note=ADP-ribosylation factor GTPase-activating protein 3
ARFGAP3	Q9NP61	87	131	1	516	Chain	ID=PRO_0000074193;Note=ADP-ribosylation factor GTPase-activating protein 3
ARFGAP3	Q9NP61	87	131	10	126	Domain	Note=Arf-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00288
ARFGAP3	Q9NP61	355	398	348	377	Compositional bias	Note=Ser-rich
ARFGAP3	Q9NP61	355	398	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
ARFGAP3	Q9NP61	87	131	88	131	Alternative sequence	ID=VSP_046888;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARFGAP3	Q9NP61	355	398	355	355	Natural variant	ID=VAR_013447;Note=S->R;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:15592455,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15461802,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1018448,PMID:15592455,PMID:14702039,PMID:15461802,PMID:15489334
ARFGAP3	Q9NP61	355	398	370	370	Natural variant	ID=VAR_055524;Note=S->G;Dbxref=dbSNP:rs16986123
ARFGAP3	Q9NP61	87	131	84	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRW
ARFGAP3	Q9NP61	87	131	101	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRW
ARFGAP3	Q9NP61	87	131	108	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRW
ARFGAP3	Q9NP61	87	131	129	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRW
ASPN	Q9BXN1	200	237	33	380	Chain	ID=PRO_0000032728;Note=Asporin
ASPN	Q9BXN1	200	237	196	219	Repeat	Note=LRR 5
ASPN	Q9BXN1	200	237	166	212	Region	Note=Interaction with TGFB1;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASPHD1	Q5U4P2	316	354	1	390	Chain	ID=PRO_0000254595;Note=Aspartate beta-hydroxylase domain-containing protein 1
ASPHD1	Q5U4P2	316	354	96	390	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACRV1	P26436	184	224	22	265	Chain	ID=PRO_0000020760;Note=Acrosomal protein SP-10
ACRV1	P26436	184	224	41	224	Alternative sequence	ID=VSP_004124;Note=In isoform 11. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACRV1	P26436	184	224	41	184	Alternative sequence	ID=VSP_004123;Note=In isoform 10. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACRV1	P26436	184	224	166	184	Alternative sequence	ID=VSP_004127;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACRV1	P26436	184	224	185	224	Alternative sequence	ID=VSP_004128;Note=In isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP1B1	P05026	32	75	1	303	Chain	ID=PRO_0000219097;Note=Sodium/potassium-transporting ATPase subunit beta-1
ATP1B1	P05026	75	127	1	303	Chain	ID=PRO_0000219097;Note=Sodium/potassium-transporting ATPase subunit beta-1
ATP1B1	P05026	32	75	1	303	Chain	ID=PRO_0000219097;Note=Sodium/potassium-transporting ATPase subunit beta-1
ATP1B1	P05026	75	127	1	303	Chain	ID=PRO_0000219097;Note=Sodium/potassium-transporting ATPase subunit beta-1
ATP1B1	P05026	32	75	1	34	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	32	75	1	34	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	32	75	35	62	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	32	75	35	62	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	32	75	63	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	75	127	63	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	32	75	63	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	75	127	63	303	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP1B1	P05026	75	127	101	101	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14094
ATP1B1	P05026	75	127	101	101	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14094
ATP1B1	P05026	75	127	126	149	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP1B1	P05026	75	127	126	149	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ATP2B3	Q16720	305	319	1	1220	Chain	ID=PRO_0000046218;Note=Plasma membrane calcium-transporting ATPase 3
ATP2B3	Q16720	305	319	1	1220	Chain	ID=PRO_0000046218;Note=Plasma membrane calcium-transporting ATPase 3
ATP2B3	Q16720	305	319	177	364	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B3	Q16720	305	319	177	364	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP2B3	Q16720	305	319	306	319	Alternative sequence	ID=VSP_000392;Note=In isoform ZA%2C isoform ZB%2C isoform ZE and isoform ZG. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP2B3	Q16720	305	319	306	319	Alternative sequence	ID=VSP_000392;Note=In isoform ZA%2C isoform ZB%2C isoform ZE and isoform ZG. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATOH8	Q96SQ7	256	320	1	321	Chain	ID=PRO_0000323751;Note=Protein atonal homolog 8
ATOH8	Q96SQ7	256	320	230	282	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
ATOH8	Q96SQ7	256	320	244	282	Region	Note=Helix-loop-helix motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
ATPAF1	Q5TC12	163	180	58	328	Chain	ID=PRO_0000318915;Note=ATP synthase mitochondrial F1 complex assembly factor 1
ACTR8	Q9H981	355	387	1	624	Chain	ID=PRO_0000089123;Note=Actin-related protein 8
ACTR8	Q9H981	98	135	1	624	Chain	ID=PRO_0000089123;Note=Actin-related protein 8
ACTR8	Q9H981	98	135	132	132	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
ACTR8	Q9H981	98	135	1	250	Alternative sequence	ID=VSP_040506;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ACTR8	Q9H981	98	135	1	111	Alternative sequence	ID=VSP_040507;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ACTR8	Q9H981	98	135	95	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO0
ACTR8	Q9H981	98	135	102	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO0
ACTR8	Q9H981	98	135	133	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO0
ACTR8	Q9H981	355	387	361	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO0
ACTR8	Q9H981	355	387	374	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO0
ACTR8	Q9H981	355	387	384	390	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FO0
ACTR2	P61160	53	125	1	394	Chain	ID=PRO_0000089067;Note=Actin-related protein 2
ACTR2	P61160	195	245	1	394	Chain	ID=PRO_0000089067;Note=Actin-related protein 2
ACTR2	P61160	195	245	214	218	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A7MB62
ACTR2	P61160	53	125	53	53	Alternative sequence	ID=VSP_046178;Note=In isoform 2. K->KNNKKM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ACTR2	P61160	53	125	67	67	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASB11	Q8WXH4	87	123	1	323	Chain	ID=PRO_0000066944;Note=Ankyrin repeat and SOCS box protein 11
ASB11	Q8WXH4	87	123	64	93	Repeat	Note=ANK 1
ASB11	Q8WXH4	87	123	97	126	Repeat	Note=ANK 2
ASB11	Q8WXH4	87	123	88	104	Alternative sequence	ID=VSP_043087;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ASB11	Q8WXH4	87	123	78	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUC
ASB11	Q8WXH4	87	123	101	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUC
ASB11	Q8WXH4	87	123	111	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUC
ASPDH	A6ND91	94	144	1	283	Chain	ID=PRO_0000300623;Note=Putative L-aspartate dehydrogenase
ASPDH	A6ND91	94	144	127	127	Binding site	Note=NAD%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250
ASPDH	A6ND91	94	144	95	144	Alternative sequence	ID=VSP_038743;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASAP2	O43150	115	140	1	1006	Chain	ID=PRO_0000074198;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 2
ASAP2	O43150	254	283	1	1006	Chain	ID=PRO_0000074198;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 2
ASAP2	O43150	672	710	1	1006	Chain	ID=PRO_0000074198;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 2
ASAP2	O43150	794	839	1	1006	Chain	ID=PRO_0000074198;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 2
ASAP2	O43150	941	982	1	1006	Chain	ID=PRO_0000074198;Note=Arf-GAP with SH3 domain%2C ANK repeat and PH domain-containing protein 2
ASAP2	O43150	941	982	944	1006	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
ASAP2	O43150	254	283	256	283	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ASAP2	O43150	794	839	771	936	Compositional bias	Note=Pro-rich
ASAP2	O43150	672	710	701	701	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18088087,PMID:20068231,PMID:21406692,PMID:23186163
ASAP2	O43150	794	839	822	822	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ASAP2	O43150	794	839	795	840	Alternative sequence	ID=VSP_009722;Note=In isoform 2. VQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATAD5	Q96QE3	985	1045	1	1844	Chain	ID=PRO_0000317618;Note=ATPase family AAA domain-containing protein 5
ATAD5	Q96QE3	1202	1261	1	1844	Chain	ID=PRO_0000317618;Note=ATPase family AAA domain-containing protein 5
ATAD5	Q96QE3	1202	1261	1205	1844	Alternative sequence	ID=VSP_031097;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATAD5	Q96QE3	1202	1261	1203	1203	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATF6	P18850	440	477	1	670	Chain	ID=PRO_0000076589;Note=Cyclic AMP-dependent transcription factor ATF-6 alpha
ATF6	P18850	440	477	399	670	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATF6	P18850	440	477	468	589	Region	Note=Interaction with THBS4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22682248;Dbxref=PMID:22682248
ATF6	P18850	440	477	463	466	Compositional bias	Note=Poly-Pro
ATF6	P18850	440	477	472	472	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14699159;Dbxref=PMID:14699159
ATF6	P18850	440	477	474	474	Mutagenesis	Note=Loss of glycosylation at Asn-472 and increase of Golgi translocation rate. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14699159;Dbxref=PMID:14699159
ATG2B	Q96BY7	340	402	1	2078	Chain	ID=PRO_0000089909;Note=Autophagy-related protein 2 homolog B
ATG2B	Q96BY7	340	402	379	379	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80XK6
CCNI2	Q6ZMN8	258	335	1	369	Chain	ID=PRO_0000335821;Note=Cyclin-I2
CCNI2	Q6ZMN8	258	335	258	258	Alternative sequence	ID=VSP_057180;Note=In isoform 2. I->IEKYGVFCSNIKNHGLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCNL1	Q9UK58	378	410	1	526	Chain	ID=PRO_0000080480;Note=Cyclin-L1
CCNL1	Q9UK58	378	410	390	432	Region	Note=RS
CCNL1	Q9UK58	378	410	173	526	Alternative sequence	ID=VSP_016121;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11980906;Dbxref=PMID:11980906
CCNL1	Q9UK58	378	410	233	526	Alternative sequence	ID=VSP_016123;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11980906;Dbxref=PMID:11980906
CCNT2	O60583	80	123	1	730	Chain	ID=PRO_0000080495;Note=Cyclin-T2
CCNT2	O60583	143	164	1	730	Chain	ID=PRO_0000080495;Note=Cyclin-T2
CCNT2	O60583	80	123	12	147	Domain	Note=Cyclin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CCNT2	O60583	143	164	12	147	Domain	Note=Cyclin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CCNT2	O60583	80	123	1	300	Region	Note=Interaction with MDFIC and MDFI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17289077;Dbxref=PMID:17289077
CCNT2	O60583	143	164	1	300	Region	Note=Interaction with MDFIC and MDFI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17289077;Dbxref=PMID:17289077
CCNT2	O60583	80	123	79	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IVX
CCNT2	O60583	80	123	100	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IVX
CCNT2	O60583	80	123	123	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IVX
CCNT2	O60583	143	164	143	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IVX
CCNT2	O60583	143	164	152	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IVX
CDC123	O75794	25	48	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	68	79	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	79	111	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	188	229	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	239	282	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	282	328	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	79	111	93	93	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC123	O75794	282	328	317	317	Sequence conflict	Note=E->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD80	P33681	233	265	35	288	Chain	ID=PRO_0000014547;Note=T-lymphocyte activation antigen CD80
CD80	P33681	233	265	35	288	Chain	ID=PRO_0000014547;Note=T-lymphocyte activation antigen CD80
CD80	P33681	233	265	35	242	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD80	P33681	233	265	35	242	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD80	P33681	233	265	243	263	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD80	P33681	233	265	243	263	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD80	P33681	233	265	264	288	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD80	P33681	233	265	264	288	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD80	P33681	233	265	141	266	Alternative sequence	ID=VSP_047699;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17953528;Dbxref=PMID:17953528
CD80	P33681	233	265	141	266	Alternative sequence	ID=VSP_047699;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17953528;Dbxref=PMID:17953528
CD80	P33681	233	265	234	266	Alternative sequence	ID=VSP_047700;Note=In isoform 2. TKQEHFPDNLLPSWAITLISVNGIFVICCLTYC->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17953528;Dbxref=PMID:17953528
CD80	P33681	233	265	234	266	Alternative sequence	ID=VSP_047700;Note=In isoform 2. TKQEHFPDNLLPSWAITLISVNGIFVICCLTYC->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17953528;Dbxref=PMID:17953528
CD82	P27701	87	112	1	267	Chain	ID=PRO_0000219226;Note=CD82 antigen
CD82	P27701	112	146	1	267	Chain	ID=PRO_0000219226;Note=CD82 antigen
CD82	P27701	146	214	1	267	Chain	ID=PRO_0000219226;Note=CD82 antigen
CD82	P27701	214	242	1	267	Chain	ID=PRO_0000219226;Note=CD82 antigen
CD82	P27701	87	112	84	110	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	87	112	111	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	112	146	111	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	146	214	111	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	214	242	111	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	214	242	229	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	112	146	129	129	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:19159218,PMID:19349973
CD82	P27701	146	214	157	157	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD82	P27701	146	214	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
CD82	P27701	87	112	88	112	Alternative sequence	ID=VSP_045656;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CD82	P27701	112	146	88	112	Alternative sequence	ID=VSP_045656;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CD82	P27701	214	242	241	241	Natural variant	ID=VAR_052326;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4,ECO:0000269|Ref.8;Dbxref=dbSNP:rs1139971,PMID:15489334
CD82	P27701	112	146	124	124	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD82	P27701	214	242	240	241	Sequence conflict	Note=II->MV;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDK20	Q8IZL9	167	187	1	346	Chain	ID=PRO_0000085701;Note=Cyclin-dependent kinase 20
CDK20	Q8IZL9	25	63	1	346	Chain	ID=PRO_0000085701;Note=Cyclin-dependent kinase 20
CDK20	Q8IZL9	167	187	4	288	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK20	Q8IZL9	25	63	4	288	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK20	Q8IZL9	25	63	33	33	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK20	Q8IZL9	25	63	25	25	Alternative sequence	ID=VSP_043294;Note=In isoform 4. E->EPRVGWQCLPSILQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDK20	Q8IZL9	167	187	168	243	Alternative sequence	ID=VSP_016748;Note=In isoform 2. WYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFK->SSLSCRTTTRSPLRSRCPCPWRRCCLTSLPRHWICWVNSFSTLLTSASQLPRLSSISTSSQLPCLPIHLSCRFLSV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
CDK20	Q8IZL9	167	187	168	188	Alternative sequence	ID=VSP_016749;Note=In isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
CDK20	Q8IZL9	25	63	30	30	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDK20	Q8IZL9	25	63	30	30	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDPF1	Q6NVV7	0	37	1	123	Chain	ID=PRO_0000341360;Note=Cysteine-rich DPF motif domain-containing protein 1
CDPF1	Q6NVV7	0	37	5	5	Natural variant	ID=VAR_044058;Note=V->A;Dbxref=dbSNP:rs9627281
CDK2	P24941	105	162	1	298	Chain	ID=PRO_0000085769;Note=Cyclin-dependent kinase 2
CDK2	P24941	162	196	1	298	Chain	ID=PRO_0000085769;Note=Cyclin-dependent kinase 2
CDK2	P24941	105	162	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK2	P24941	162	196	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK2	P24941	105	162	129	132	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:17095507,ECO:0000269|PubMed:21565702;Dbxref=PMID:17095507,PMID:21565702
CDK2	P24941	105	162	127	127	Active site	Note=Proton acceptor
CDK2	P24941	105	162	132	132	Metal binding	Note=Magnesium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21565702;Dbxref=PMID:21565702
CDK2	P24941	105	162	145	145	Metal binding	Note=Magnesium;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21565702;Dbxref=PMID:21565702
CDK2	P24941	105	162	145	145	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:17095507,ECO:0000269|PubMed:21565702;Dbxref=PMID:17095507,PMID:21565702
CDK2	P24941	162	196	166	166	Site	Note=CDK7 binding
CDK2	P24941	105	162	160	160	Modified residue	Note=Phosphothreonine%3B by CAK and CCRK;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:1396589,ECO:0000269|PubMed:14597612,ECO:0000269|PubMed:16325401,ECO:0000269|PubMed:17095507,ECO:0000269|PubMed:17570665,ECO:0000269|PubMed:20147522,ECO:0000269|PubMed:20360007,ECO:0000269|PubMed:21565702,ECO:0000305|PubMed:28666995;Dbxref=PMID:1396589,PMID:14597612,PMID:16325401,PMID:17095507,PMID:17570665,PMID:20147522,PMID:20360007,PMID:21565702,PMID:28666995
CDK2	P24941	162	196	163	196	Alternative sequence	ID=VSP_041998;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDK2	P24941	105	162	160	160	Mutagenesis	Note=Abolishes activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1396589;Dbxref=PMID:1396589
CDK2	P24941	162	196	166	166	Mutagenesis	Note=Reduced phosphorylation by CAK and reduced kinase activity. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17373709;Dbxref=PMID:17373709
CDK2	P24941	105	162	101	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDK2	P24941	105	162	130	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDK2	P24941	105	162	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDK2	P24941	105	162	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B54
CDK2	P24941	105	162	141	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDK2	P24941	105	162	148	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDK2	P24941	105	162	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FKO
CDK2	P24941	105	162	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RAI
CDK2	P24941	105	162	162	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GCJ
CDK2	P24941	162	196	162	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GCJ
CDK2	P24941	162	196	171	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDK2	P24941	162	196	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OKW
CDK2	P24941	162	196	183	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EK4
CDS1	Q92903	270	293	1	461	Chain	ID=PRO_0000090713;Note=Phosphatidate cytidylyltransferase 1
CDS1	Q92903	344	384	1	461	Chain	ID=PRO_0000090713;Note=Phosphatidate cytidylyltransferase 1
CDS1	Q92903	270	293	279	299	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDS1	Q92903	344	384	357	377	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDK7	P50613	76	99	2	346	Chain	ID=PRO_0000085791;Note=Cyclin-dependent kinase 7
CDK7	P50613	99	136	2	346	Chain	ID=PRO_0000085791;Note=Cyclin-dependent kinase 7
CDK7	P50613	209	238	2	346	Chain	ID=PRO_0000085791;Note=Cyclin-dependent kinase 7
CDK7	P50613	238	288	2	346	Chain	ID=PRO_0000085791;Note=Cyclin-dependent kinase 7
CDK7	P50613	76	99	12	295	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK7	P50613	99	136	12	295	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK7	P50613	209	238	12	295	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK7	P50613	238	288	12	295	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK7	P50613	238	288	285	285	Natural variant	ID=VAR_023119;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.6;Dbxref=dbSNP:rs34584424,PMID:17344846
CDK7	P50613	76	99	91	91	Mutagenesis	Note=Enhanced capacity to bind ATP analogs. F->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16327805;Dbxref=PMID:16327805
CDK7	P50613	99	136	130	130	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDK7	P50613	238	288	249	249	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDK7	P50613	76	99	77	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	76	99	88	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	76	99	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	76	99	98	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	99	136	98	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	99	136	113	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	209	238	218	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	209	238	234	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	209	238	237	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	238	288	237	239	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	238	288	257	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	238	288	266	276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	238	288	280	282	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CDK7	P50613	238	288	286	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UA2
CEP112	Q8N8E3	819	869	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	798	819	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	721	798	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	358	406	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	188	214	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	819	869	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	798	819	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	721	798	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	358	406	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	188	214	1	955	Chain	ID=PRO_0000234508;Note=Centrosomal protein of 112 kDa
CEP112	Q8N8E3	819	869	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	798	819	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	721	798	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	358	406	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	819	869	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	798	819	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	721	798	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	358	406	277	954	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP112	Q8N8E3	721	798	1	744	Alternative sequence	ID=VSP_018338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	358	406	1	744	Alternative sequence	ID=VSP_018338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	188	214	1	744	Alternative sequence	ID=VSP_018338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	721	798	1	744	Alternative sequence	ID=VSP_018338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	358	406	1	744	Alternative sequence	ID=VSP_018338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	188	214	1	744	Alternative sequence	ID=VSP_018338;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	721	798	745	797	Alternative sequence	ID=VSP_018339;Note=In isoform 2. KQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLE->MWASLSLDHPSAKENQALRLIEMREENGNVPKTEQAGSLKPLRDTGKSNLKEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP112	Q8N8E3	721	798	745	797	Alternative sequence	ID=VSP_018339;Note=In isoform 2. KQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLE->MWASLSLDHPSAKENQALRLIEMREENGNVPKTEQAGSLKPLRDTGKSNLKEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEACAM6	P40199	234	319	35	320	Chain	ID=PRO_0000014568;Note=Carcinoembryonic antigen-related cell adhesion molecule 6
CEACAM6	P40199	234	319	240	314	Domain	Note=Ig-like C2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CEACAM6	P40199	234	319	256	256	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
CEACAM6	P40199	234	319	274	274	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
CEACAM6	P40199	234	319	288	288	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
CEACAM6	P40199	234	319	292	292	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
CEACAM6	P40199	234	319	309	309	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498
CEACAM6	P40199	234	319	259	299	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CEACAM6	P40199	234	319	239	239	Natural variant	ID=VAR_034680;Note=G->V;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18318008,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:3337731,ECO:0000269|Ref.4;Dbxref=dbSNP:rs11548735,PMID:18318008,PMID:14702039,PMID:15489334,PMID:3337731
CELSR2	Q9HCU4	1569	1611	32	2923	Chain	ID=PRO_0000012916;Note=Cadherin EGF LAG seven-pass G-type receptor 2
CELSR2	Q9HCU4	1970	2004	32	2923	Chain	ID=PRO_0000012916;Note=Cadherin EGF LAG seven-pass G-type receptor 2
CELSR2	Q9HCU4	2036	2106	32	2923	Chain	ID=PRO_0000012916;Note=Cadherin EGF LAG seven-pass G-type receptor 2
CELSR2	Q9HCU4	2167	2210	32	2923	Chain	ID=PRO_0000012916;Note=Cadherin EGF LAG seven-pass G-type receptor 2
CELSR2	Q9HCU4	1569	1611	32	2380	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	1970	2004	32	2380	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	2036	2106	32	2380	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	2167	2210	32	2380	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	1569	1611	1367	1571	Domain	Note=Laminin G-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CELSR2	Q9HCU4	1569	1611	1574	1610	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CELSR2	Q9HCU4	1970	2004	1924	1971	Domain	Note=Laminin EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00460
CELSR2	Q9HCU4	1569	1611	1591	1591	Modified residue	Note=(3R)-3-hydroxyasparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	2036	2106	2043	2043	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	2036	2106	2061	2061	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR2	Q9HCU4	1569	1611	1545	1571	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CELSR2	Q9HCU4	1569	1611	1578	1589	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CELSR2	Q9HCU4	1569	1611	1583	1598	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CELSR2	Q9HCU4	1569	1611	1600	1609	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CELSR2	Q9HCU4	1970	2004	1992	1992	Natural variant	ID=VAR_049475;Note=G->R;Dbxref=dbSNP:rs12567377
CEP63	Q96MT8	106	147	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	147	185	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	310	355	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	106	147	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	147	185	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	310	355	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	106	147	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	147	185	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	310	355	1	703	Chain	ID=PRO_0000089493;Note=Centrosomal protein of 63 kDa
CEP63	Q96MT8	106	147	22	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	147	185	22	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	106	147	22	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	147	185	22	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	106	147	22	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	147	185	22	199	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	310	355	353	533	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	310	355	353	533	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	310	355	353	533	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP63	Q96MT8	310	355	310	355	Alternative sequence	ID=VSP_012251;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CEP63	Q96MT8	310	355	310	355	Alternative sequence	ID=VSP_012251;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CEP63	Q96MT8	310	355	310	355	Alternative sequence	ID=VSP_012251;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
C6orf62	Q9GZU0	143	188	1	229	Chain	ID=PRO_0000089514;Note=Uncharacterized protein C6orf62
C6orf62	Q9GZU0	102	143	1	229	Chain	ID=PRO_0000089514;Note=Uncharacterized protein C6orf62
C6orf62	Q9GZU0	102	143	116	116	Natural variant	ID=VAR_050803;Note=W->C;Dbxref=dbSNP:rs34238213
C6orf62	Q9GZU0	102	143	140	140	Natural variant	ID=VAR_050804;Note=R->S;Dbxref=dbSNP:rs35050510
CHD2	O14647	148	183	1	1828	Chain	ID=PRO_0000080226;Note=Chromodomain-helicase-DNA-binding protein 2
CHD2	O14647	384	399	1	1828	Chain	ID=PRO_0000080226;Note=Chromodomain-helicase-DNA-binding protein 2
CHD2	O14647	784	835	1	1828	Chain	ID=PRO_0000080226;Note=Chromodomain-helicase-DNA-binding protein 2
CHD2	O14647	1138	1151	1	1828	Chain	ID=PRO_0000080226;Note=Chromodomain-helicase-DNA-binding protein 2
CHD2	O14647	1295	1336	1	1828	Chain	ID=PRO_0000080226;Note=Chromodomain-helicase-DNA-binding protein 2
CHD2	O14647	1426	1471	1	1828	Chain	ID=PRO_0000080226;Note=Chromodomain-helicase-DNA-binding protein 2
CHD2	O14647	384	399	378	456	Domain	Note=Chromo 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
CHD2	O14647	784	835	795	946	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
CHD2	O14647	784	835	502	1828	Alternative sequence	ID=VSP_042791;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
CHD2	O14647	1138	1151	502	1828	Alternative sequence	ID=VSP_042791;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
CHD2	O14647	1295	1336	502	1828	Alternative sequence	ID=VSP_042791;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
CHD2	O14647	1426	1471	502	1828	Alternative sequence	ID=VSP_042791;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
CHD2	O14647	148	183	112	1828	Natural variant	ID=VAR_078614;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
CHD2	O14647	384	399	112	1828	Natural variant	ID=VAR_078614;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
CHD2	O14647	784	835	112	1828	Natural variant	ID=VAR_078614;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
CHD2	O14647	1138	1151	112	1828	Natural variant	ID=VAR_078614;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
CHD2	O14647	1295	1336	112	1828	Natural variant	ID=VAR_078614;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
CHD2	O14647	1426	1471	112	1828	Natural variant	ID=VAR_078614;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
CHD2	O14647	148	183	121	1828	Natural variant	ID=VAR_078615;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
CHD2	O14647	384	399	121	1828	Natural variant	ID=VAR_078615;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
CHD2	O14647	784	835	121	1828	Natural variant	ID=VAR_078615;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
CHD2	O14647	1138	1151	121	1828	Natural variant	ID=VAR_078615;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
CHD2	O14647	1295	1336	121	1828	Natural variant	ID=VAR_078615;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
CHD2	O14647	1426	1471	121	1828	Natural variant	ID=VAR_078615;Note=In EEOC. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=PMID:23708187
CHD2	O14647	784	835	823	823	Natural variant	ID=VAR_070210;Note=In EEOC. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23708187;Dbxref=dbSNP:rs864309540,PMID:23708187
CHD3	Q12873	501	569	1	2000	Chain	ID=PRO_0000080227;Note=Chromodomain-helicase-DNA-binding protein 3
CHD3	Q12873	640	683	1	2000	Chain	ID=PRO_0000080227;Note=Chromodomain-helicase-DNA-binding protein 3
CHD3	Q12873	848	894	1	2000	Chain	ID=PRO_0000080227;Note=Chromodomain-helicase-DNA-binding protein 3
CHD3	Q12873	1040	1084	1	2000	Chain	ID=PRO_0000080227;Note=Chromodomain-helicase-DNA-binding protein 3
CHD3	Q12873	1357	1379	1	2000	Chain	ID=PRO_0000080227;Note=Chromodomain-helicase-DNA-binding protein 3
CHD3	Q12873	501	569	494	594	Domain	Note=Chromo 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
CHD3	Q12873	640	683	631	673	Domain	Note=Chromo 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
CHD3	Q12873	848	894	748	932	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
CHD3	Q12873	1040	1084	1064	1229	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
CHD3	Q12873	501	569	456	503	Zinc finger	Note=PHD-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146
CHD3	Q12873	848	894	883	886	Motif	Note=DEAH box
CHD3	Q12873	1357	1379	1367	1367	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CHD3	Q12873	640	683	653	653	Sequence conflict	Note=W->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCNB2	O95067	51	89	1	398	Chain	ID=PRO_0000080361;Note=G2/mitotic-specific cyclin-B2
CCNB2	O95067	146	199	1	398	Chain	ID=PRO_0000080361;Note=G2/mitotic-specific cyclin-B2
CCNB2	O95067	278	325	1	398	Chain	ID=PRO_0000080361;Note=G2/mitotic-specific cyclin-B2
CCNB2	O95067	51	89	77	77	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCNF	P41002	198	233	1	786	Chain	ID=PRO_0000080463;Note=Cyclin-F
CCNF	P41002	233	259	1	786	Chain	ID=PRO_0000080463;Note=Cyclin-F
CCNF	P41002	233	259	252	252	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
MS4A1	P11836	112	191	1	297	Chain	ID=PRO_0000158627;Note=B-lymphocyte antigen CD20
MS4A1	P11836	112	191	1	297	Chain	ID=PRO_0000158627;Note=B-lymphocyte antigen CD20
MS4A1	P11836	112	191	1	297	Chain	ID=PRO_0000158627;Note=B-lymphocyte antigen CD20
MS4A1	P11836	112	191	106	120	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	106	120	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	106	120	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	121	141	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	121	141	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	121	141	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	142	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	142	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	142	188	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	189	209	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
MS4A1	P11836	112	191	146	160	Region	Note=Epitope 2
MS4A1	P11836	112	191	146	160	Region	Note=Epitope 2
MS4A1	P11836	112	191	146	160	Region	Note=Epitope 2
MS4A1	P11836	112	191	168	175	Region	Note=Epitope 3 (recognized by antibodies%2C including Rituximab)
MS4A1	P11836	112	191	168	175	Region	Note=Epitope 3 (recognized by antibodies%2C including Rituximab)
MS4A1	P11836	112	191	168	175	Region	Note=Epitope 3 (recognized by antibodies%2C including Rituximab)
MS4A1	P11836	112	191	167	183	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21444918;Dbxref=PMID:21444918
MS4A1	P11836	112	191	167	183	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21444918;Dbxref=PMID:21444918
MS4A1	P11836	112	191	167	183	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21444918;Dbxref=PMID:21444918
MS4A1	P11836	112	191	38	204	Alternative sequence	ID=VSP_057058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MS4A1	P11836	112	191	38	204	Alternative sequence	ID=VSP_057058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MS4A1	P11836	112	191	38	204	Alternative sequence	ID=VSP_057058;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MS4A1	P11836	112	191	159	159	Mutagenesis	Note=Abrogates recognition by some antibodies%3B when associated with D-163 and D-166. Slight decrease of rituximab binding%3B when associated with D-163 and D-166. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	159	159	Mutagenesis	Note=Abrogates recognition by some antibodies%3B when associated with D-163 and D-166. Slight decrease of rituximab binding%3B when associated with D-163 and D-166. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	159	159	Mutagenesis	Note=Abrogates recognition by some antibodies%3B when associated with D-163 and D-166. Slight decrease of rituximab binding%3B when associated with D-163 and D-166. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	163	163	Mutagenesis	Note=Decreased binding of some antibodies. No effect on rituximab binding. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	163	163	Mutagenesis	Note=Decreased binding of some antibodies. No effect on rituximab binding. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	163	163	Mutagenesis	Note=Decreased binding of some antibodies. No effect on rituximab binding. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	166	166	Mutagenesis	Note=Decreased binding of some antibodies. No effect on rituximab binding. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	166	166	Mutagenesis	Note=Decreased binding of some antibodies. No effect on rituximab binding. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	166	166	Mutagenesis	Note=Decreased binding of some antibodies. No effect on rituximab binding. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	170	170	Mutagenesis	Note=Abrogates recognition by therapeutic antibodies%2C including rituximab%3B when associated with S-172. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	170	170	Mutagenesis	Note=Abrogates recognition by therapeutic antibodies%2C including rituximab%3B when associated with S-172. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	170	170	Mutagenesis	Note=Abrogates recognition by therapeutic antibodies%2C including rituximab%3B when associated with S-172. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	172	172	Mutagenesis	Note=Marked reduction in rituximab binding. Abrogates recognition by antibodies%2C including rituximab%3B when associated with S-170. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	172	172	Mutagenesis	Note=Marked reduction in rituximab binding. Abrogates recognition by antibodies%2C including rituximab%3B when associated with S-170. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	172	172	Mutagenesis	Note=Marked reduction in rituximab binding. Abrogates recognition by antibodies%2C including rituximab%3B when associated with S-170. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16785532;Dbxref=PMID:16785532
MS4A1	P11836	112	191	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP4
MS4A1	P11836	112	191	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP4
MS4A1	P11836	112	191	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP4
MS4A1	P11836	112	191	178	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP4
MS4A1	P11836	112	191	178	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP4
MS4A1	P11836	112	191	178	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP4
CD244	Q9BZW8	283	303	22	370	Chain	ID=PRO_0000014668;Note=Natural killer cell receptor 2B4
CD244	Q9BZW8	126	223	22	370	Chain	ID=PRO_0000014668;Note=Natural killer cell receptor 2B4
CD244	Q9BZW8	126	223	22	229	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	283	303	251	370	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	126	223	22	127	Domain	Note=Ig-like 1
CD244	Q9BZW8	126	223	131	215	Domain	Note=Ig-like 2
CD244	Q9BZW8	283	303	295	300	Motif	Note=ITSM 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13291
CD244	Q9BZW8	283	303	297	297	Modified residue	Note=Phosphotyrosine%3B by FYN;Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12458214,ECO:0000305|PubMed:15713798,ECO:0000305|PubMed:26221972;Dbxref=PMID:12458214,PMID:15713798,PMID:26221972
CD244	Q9BZW8	126	223	164	164	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	126	223	181	181	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	126	223	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	126	223	200	200	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	126	223	213	213	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD244	Q9BZW8	126	223	157	199	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD244	Q9BZW8	126	223	127	131	Alternative sequence	ID=VSP_010397;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10358138,ECO:0000303|PubMed:10359122,ECO:0000303|PubMed:10458320,ECO:0000303|PubMed:10556801,ECO:0000303|PubMed:10934222,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.7;Dbxref=PMID:10358138,PMID:10359122,PMID:10458320,PMID:10556801,PMID:10934222,PMID:15489334
CD244	Q9BZW8	126	223	128	224	Alternative sequence	ID=VSP_010398;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10934222;Dbxref=PMID:10934222
CD244	Q9BZW8	126	223	127	133	Sequence conflict	Note=ESLLPDK->GMAMCPM;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD19	P15391	29	118	20	556	Chain	ID=PRO_0000014648;Note=B-lymphocyte antigen CD19
CD19	P15391	278	315	20	556	Chain	ID=PRO_0000014648;Note=B-lymphocyte antigen CD19
CD19	P15391	476	495	20	556	Chain	ID=PRO_0000014648;Note=B-lymphocyte antigen CD19
CD19	P15391	29	118	20	291	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD19	P15391	278	315	20	291	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD19	P15391	278	315	292	313	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD19	P15391	278	315	314	556	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD19	P15391	476	495	314	556	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD19	P15391	29	118	20	113	Domain	Note=Ig-like C2-type 1
CD19	P15391	29	118	86	86	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD19	P15391	29	118	38	97	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD19	P15391	476	495	495	495	Alternative sequence	ID=VSP_047194;Note=In isoform 2. L->LA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CD19	P15391	29	118	29	29	Sequence conflict	Note=E->EG;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD19	P15391	29	118	80	80	Sequence conflict	Note=I->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD19	P15391	29	118	80	80	Sequence conflict	Note=I->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD19	P15391	29	118	80	80	Sequence conflict	Note=I->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD19	P15391	29	118	80	80	Sequence conflict	Note=I->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD19	P15391	29	118	24	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD19	P15391	29	118	34	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD19	P15391	29	118	50	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD19	P15391	29	118	61	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD19	P15391	29	118	80	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD19	P15391	29	118	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD19	P15391	29	118	108	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AL5
CD151	P48509	28	92	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	92	117	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	205	234	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	28	92	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	92	117	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	205	234	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	28	92	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	92	117	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	205	234	1	253	Chain	ID=PRO_0000219230;Note=CD151 antigen
CD151	P48509	28	92	19	39	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	19	39	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	19	39	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	40	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	40	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	40	57	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	58	78	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	58	78	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	58	78	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	79	91	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	79	91	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	79	91	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	92	117	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	92	117	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	28	92	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	92	117	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	92	117	113	221	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	205	234	113	221	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	92	117	113	221	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	205	234	113	221	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	92	117	113	221	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	205	234	113	221	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	205	234	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	205	234	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD151	P48509	205	234	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDC37L1	Q7L3B6	44	138	1	337	Chain	ID=PRO_0000318521;Note=Hsp90 co-chaperone Cdc37-like 1
CDC37L1	Q7L3B6	249	304	1	337	Chain	ID=PRO_0000318521;Note=Hsp90 co-chaperone Cdc37-like 1
CDC37L1	Q7L3B6	44	138	2	171	Region	Note=Self-association
CDC37L1	Q7L3B6	249	304	147	277	Region	Note=Self-association and interaction with Hsp90
CDC37L1	Q7L3B6	249	304	267	337	Region	Note=Interaction with Hsp70
CDC37L1	Q7L3B6	249	304	278	337	Region	Note=Required for interaction with STIP1
CDC37L1	Q7L3B6	44	138	84	122	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CDC37L1	Q7L3B6	44	138	88	88	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CDC37L1	Q7L3B6	249	304	291	291	Natural variant	ID=VAR_038755;Note=S->F;Dbxref=dbSNP:rs7036014
CD3D	P04234	91	135	22	171	Chain	ID=PRO_0000016487;Note=T-cell surface glycoprotein CD3 delta chain
CD3D	P04234	91	135	22	105	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3D	P04234	91	135	106	126	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3D	P04234	91	135	127	171	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3D	P04234	91	135	92	136	Alternative sequence	ID=VSP_045800;Note=In isoform 2. MCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGA->T;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15028279;Dbxref=PMID:15028279
CD3D	P04234	91	135	84	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CDC23	Q9UJX2	78	124	2	597	Chain	ID=PRO_0000106270;Note=Cell division cycle protein 23 homolog
CDC23	Q9UJX2	78	124	73	112	Repeat	Note=TPR 2
CDC23	Q9UJX2	78	124	114	144	Repeat	Note=TPR 3
CDC23	Q9UJX2	78	124	1	118	Alternative sequence	ID=VSP_037678;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC23	Q9UJX2	78	124	78	78	Natural variant	ID=VAR_019232;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs17228304
CDC23	Q9UJX2	78	124	83	83	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC23	Q9UJX2	78	124	105	105	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC23	Q9UJX2	78	124	78	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC23	Q9UJX2	78	124	99	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC23	Q9UJX2	78	124	112	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CD4	P01730	16	71	1	25	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15340161,ECO:0000269|PubMed:2592374;Dbxref=PMID:15340161,PMID:2592374
CD4	P01730	16	71	26	458	Chain	ID=PRO_0000014621;Note=T-cell surface glycoprotein CD4
CD4	P01730	124	202	26	458	Chain	ID=PRO_0000014621;Note=T-cell surface glycoprotein CD4
CD4	P01730	16	71	26	396	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD4	P01730	124	202	26	396	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD4	P01730	16	71	26	125	Domain	Note=Ig-like V-type
CD4	P01730	124	202	26	125	Domain	Note=Ig-like V-type
CD4	P01730	124	202	126	203	Domain	Note=Ig-like C2-type 1
CD4	P01730	16	71	41	109	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:2592374;Dbxref=PMID:2592374
CD4	P01730	124	202	155	184	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:2592374;Dbxref=PMID:2592374
CD4	P01730	124	202	191	191	Natural variant	ID=VAR_023459;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs28917504
CD4	P01730	16	71	27	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	16	71	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	16	71	44	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	16	71	51	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	16	71	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LQA
CD4	P01730	16	71	60	65	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	16	71	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	114	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	131	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NY1
CD4	P01730	124	202	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1G9N
CD4	P01730	124	202	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	152	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1CDJ
CD4	P01730	124	202	162	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	166	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	180	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CD4	P01730	124	202	191	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H8W
CDKL2	Q92772	56	121	1	493	Chain	ID=PRO_0000085814;Note=Cyclin-dependent kinase-like 2
CDKL2	Q92772	56	121	4	287	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDKL2	Q92772	56	121	77	77	Natural variant	ID=VAR_053928;Note=Y->S;Dbxref=dbSNP:rs35921414
CDKL2	Q92772	56	121	98	98	Natural variant	ID=VAR_041987;Note=In an ovarian papillary serous adenocarcinoma sample%3B somatic mutation. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
CDKL2	Q92772	56	121	42	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AAA
CDKL2	Q92772	56	121	66	72	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AAA
CDKL2	Q92772	56	121	75	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AAA
CDKL2	Q92772	56	121	84	86	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AAA
CDKL2	Q92772	56	121	87	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AAA
CDKL2	Q92772	56	121	100	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AAA
CDON	Q4KMG0	719	787	26	1287	Chain	ID=PRO_0000234054;Note=Cell adhesion molecule-related/down-regulated by oncogenes
CDON	Q4KMG0	675	719	26	1287	Chain	ID=PRO_0000234054;Note=Cell adhesion molecule-related/down-regulated by oncogenes
CDON	Q4KMG0	165	213	26	1287	Chain	ID=PRO_0000234054;Note=Cell adhesion molecule-related/down-regulated by oncogenes
CDON	Q4KMG0	719	787	26	963	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDON	Q4KMG0	675	719	26	963	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDON	Q4KMG0	165	213	26	963	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDON	Q4KMG0	165	213	120	204	Domain	Note=Ig-like C2-type 2
CDON	Q4KMG0	675	719	579	677	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CDON	Q4KMG0	719	787	723	821	Domain	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
CDON	Q4KMG0	165	213	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDON	Q4KMG0	165	213	141	191	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CDON	Q4KMG0	675	719	684	684	Natural variant	ID=VAR_066497;Note=In HPE11. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21802063;Dbxref=dbSNP:rs145983470,PMID:21802063
CDON	Q4KMG0	675	719	686	686	Natural variant	ID=VAR_056041;Note=A->V;Dbxref=dbSNP:rs12274923
CDON	Q4KMG0	675	719	689	689	Natural variant	ID=VAR_066498;Note=In HPE11. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21802063;Dbxref=dbSNP:rs387906995,PMID:21802063
CDON	Q4KMG0	675	719	691	691	Natural variant	ID=VAR_066499;Note=In HPE11. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21802063;Dbxref=dbSNP:rs139323558,PMID:21802063
CDON	Q4KMG0	719	787	780	780	Natural variant	ID=VAR_066500;Note=In HPE11. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21802063;Dbxref=dbSNP:rs387906996,PMID:21802063
CEP164	Q9UPV0	229	255	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	384	411	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	526	574	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	575	644	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	831	872	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	920	948	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	948	971	1	1460	Chain	ID=PRO_0000312494;Note=Centrosomal protein of 164 kDa
CEP164	Q9UPV0	526	574	468	955	Compositional bias	Note=Glu-rich
CEP164	Q9UPV0	575	644	468	955	Compositional bias	Note=Glu-rich
CEP164	Q9UPV0	831	872	468	955	Compositional bias	Note=Glu-rich
CEP164	Q9UPV0	920	948	468	955	Compositional bias	Note=Glu-rich
CEP164	Q9UPV0	948	971	468	955	Compositional bias	Note=Glu-rich
CEP164	Q9UPV0	526	574	566	566	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CDYL2	Q8N8U2	406	454	1	506	Chain	ID=PRO_0000080223;Note=Chromodomain Y-like protein 2
CEP290	O15078	2174	2215	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	2119	2174	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	2045	2090	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	1568	1604	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	1343	1398	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	939	997	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	147	165	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	99	147	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	34	60	1	2479	Chain	ID=PRO_0000089464;Note=Centrosomal protein of 290 kDa
CEP290	O15078	147	165	1	695	Region	Note=Self-association (with itself or C-terminus);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723859;Dbxref=PMID:18723859
CEP290	O15078	99	147	1	695	Region	Note=Self-association (with itself or C-terminus);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723859;Dbxref=PMID:18723859
CEP290	O15078	34	60	1	695	Region	Note=Self-association (with itself or C-terminus);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723859;Dbxref=PMID:18723859
CEP290	O15078	2174	2215	1966	2479	Region	Note=Self-association (with itself or N-terminus);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723859;Dbxref=PMID:18723859
CEP290	O15078	2119	2174	1966	2479	Region	Note=Self-association (with itself or N-terminus);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723859;Dbxref=PMID:18723859
CEP290	O15078	2045	2090	1966	2479	Region	Note=Self-association (with itself or N-terminus);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723859;Dbxref=PMID:18723859
CEP290	O15078	147	165	59	565	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	99	147	59	565	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	34	60	59	565	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	939	997	958	1027	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	1343	1398	1071	1498	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	1568	1604	1533	1584	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	2174	2215	1635	2452	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	2119	2174	1635	2452	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	2045	2090	1635	2452	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP290	O15078	939	997	1	940	Alternative sequence	ID=VSP_021027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
CEP290	O15078	147	165	1	940	Alternative sequence	ID=VSP_021027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
CEP290	O15078	99	147	1	940	Alternative sequence	ID=VSP_021027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
CEP290	O15078	34	60	1	940	Alternative sequence	ID=VSP_021027;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
CEP290	O15078	2119	2174	2134	2134	Natural variant	ID=VAR_075696;Note=In JBTS5%3B unknown pathological significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26477546;Dbxref=dbSNP:rs117852025,PMID:26477546
CEP290	O15078	2174	2215	2210	2210	Natural variant	ID=VAR_066997;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21493627;Dbxref=dbSNP:rs374852145,PMID:21493627
CELSR1	Q9NYQ6	2851	2926	21	3014	Chain	ID=PRO_0000012914;Note=Cadherin EGF LAG seven-pass G-type receptor 1
CELSR1	Q9NYQ6	2115	2185	21	3014	Chain	ID=PRO_0000012914;Note=Cadherin EGF LAG seven-pass G-type receptor 1
CELSR1	Q9NYQ6	2115	2185	22	2469	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR1	Q9NYQ6	2851	2926	2705	3014	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR1	Q9NYQ6	2851	2926	2871	2871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35161
CELSR1	Q9NYQ6	2851	2926	2873	2873	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35161
CELSR1	Q9NYQ6	2115	2185	2122	2122	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR1	Q9NYQ6	2851	2926	1398	3014	Alternative sequence	ID=VSP_002012;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CELSR1	Q9NYQ6	2115	2185	1398	3014	Alternative sequence	ID=VSP_002012;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CELSR1	Q9NYQ6	2851	2926	2903	2903	Natural variant	ID=VAR_049472;Note=E->Q;Dbxref=dbSNP:rs9615351
CEP97	Q8IW35	115	149	1	865	Chain	ID=PRO_0000263705;Note=Centrosomal protein of 97 kDa
CEP97	Q8IW35	115	149	103	124	Repeat	Note=LRR 4
CEP97	Q8IW35	115	149	125	146	Repeat	Note=LRR 5
CEP97	Q8IW35	115	149	147	168	Repeat	Note=LRR 6
CETN3	O15182	89	153	1	167	Chain	ID=PRO_0000073563;Note=Centrin-3
CETN3	O15182	89	153	61	96	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CETN3	O15182	89	153	98	133	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CETN3	O15182	89	153	134	167	Domain	Note=EF-hand 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CETN3	O15182	89	153	147	158	Calcium binding	Note=2;Ontology_term=ECO:0000305;evidence=ECO:0000305
CETN3	O15182	89	153	135	135	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CEP78	Q5JTW2	259	297	1	689	Chain	ID=PRO_0000291952;Note=Centrosomal protein of 78 kDa
CEP78	Q5JTW2	417	460	1	689	Chain	ID=PRO_0000291952;Note=Centrosomal protein of 78 kDa
CEP78	Q5JTW2	460	486	1	689	Chain	ID=PRO_0000291952;Note=Centrosomal protein of 78 kDa
CEP78	Q5JTW2	417	460	450	505	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP78	Q5JTW2	460	486	450	505	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP78	Q5JTW2	417	460	451	451	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CP	P00450	621	692	20	1065	Chain	ID=PRO_0000002912;Note=Ceruloplasmin
CP	P00450	202	260	20	1065	Chain	ID=PRO_0000002912;Note=Ceruloplasmin
CP	P00450	131	202	20	1065	Chain	ID=PRO_0000002912;Note=Ceruloplasmin
CP	P00450	202	260	20	357	Domain	Note=F5/8 type A 1
CP	P00450	131	202	20	357	Domain	Note=F5/8 type A 1
CP	P00450	131	202	20	200	Domain	Note=Plastocyanin-like 1
CP	P00450	202	260	209	357	Domain	Note=Plastocyanin-like 2
CP	P00450	621	692	370	718	Domain	Note=F5/8 type A 2
CP	P00450	621	692	570	718	Domain	Note=Plastocyanin-like 4
CP	P00450	131	202	180	180	Metal binding	Note=Copper 2%3B type 3
CP	P00450	131	202	182	182	Metal binding	Note=Copper 3%3B type 3
CP	P00450	621	692	656	656	Metal binding	Note=Copper 5%3B type 1
CP	P00450	131	202	138	138	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19838169;Dbxref=PMID:14760718,PMID:15084671,PMID:16335952,PMID:19139490,PMID:19159218,PMID:19838169
CP	P00450	131	202	174	200	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
CP	P00450	621	692	637	718	Disulfide bond	Ontology_term=ECO:0000305;evidence=ECO:0000305
CP	P00450	131	202	141	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	131	202	145	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	131	202	154	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	131	202	173	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	131	202	185	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	131	202	194	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	202	260	205	210	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J5W
CP	P00450	202	260	214	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	202	260	226	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	202	260	232	239	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	202	260	243	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	202	260	251	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	202	260	258	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	619	623	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	635	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	642	647	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	656	660	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	665	667	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	670	677	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CP	P00450	621	692	682	687	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ENZ
CFDP1	Q9UEE9	217	269	1	299	Chain	ID=PRO_0000212494;Note=Craniofacial development protein 1
CFDP1	Q9UEE9	177	216	1	299	Chain	ID=PRO_0000212494;Note=Craniofacial development protein 1
CFDP1	Q9UEE9	217	269	218	299	Domain	Note=BCNT-C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00610
CFDP1	Q9UEE9	217	269	178	217	Region	Note=Hydrophilic
CFDP1	Q9UEE9	177	216	178	217	Region	Note=Hydrophilic
CFDP1	Q9UEE9	177	216	216	216	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CFDP1	Q9UEE9	217	269	219	219	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
CFDP1	Q9UEE9	217	269	250	250	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CFDP1	Q9UEE9	217	269	218	299	Alternative sequence	ID=VSP_016242;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9006920;Dbxref=PMID:9006920
CGNL1	Q0VF96	730	801	1	1302	Chain	ID=PRO_0000312875;Note=Cingulin-like protein 1
CGNL1	Q0VF96	1013	1067	1	1302	Chain	ID=PRO_0000312875;Note=Cingulin-like protein 1
CGNL1	Q0VF96	1067	1097	1	1302	Chain	ID=PRO_0000312875;Note=Cingulin-like protein 1
CGNL1	Q0VF96	730	801	604	1258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CGNL1	Q0VF96	1013	1067	604	1258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CGNL1	Q0VF96	1067	1097	604	1258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CGNL1	Q0VF96	730	801	748	749	Sequence conflict	Note=EQ->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305
CGNL1	Q0VF96	730	801	748	749	Sequence conflict	Note=EQ->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305
CGNL1	Q0VF96	1013	1067	1013	1013	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CGNL1	Q0VF96	1013	1067	1013	1013	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CGNL1	Q0VF96	1067	1097	1068	1068	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CGNL1	Q0VF96	1067	1097	1088	1088	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX47	Q9H0S4	60	123	2	455	Chain	ID=PRO_0000055050;Note=Probable ATP-dependent RNA helicase DDX47
DDX47	Q9H0S4	250	299	2	455	Chain	ID=PRO_0000055050;Note=Probable ATP-dependent RNA helicase DDX47
DDX47	Q9H0S4	60	123	55	226	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX47	Q9H0S4	250	299	237	397	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX47	Q9H0S4	60	123	68	75	Nucleotide binding	Note=ATP
DDX47	Q9H0S4	250	299	251	299	Alternative sequence	ID=VSP_045239;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
DDX47	Q9H0S4	60	123	64	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BER
DDX47	Q9H0S4	60	123	74	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BER
DDX47	Q9H0S4	60	123	95	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BER
DDX47	Q9H0S4	60	123	102	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BER
DDX47	Q9H0S4	60	123	117	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BER
DDX47	Q9H0S4	60	123	123	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BER
DDX49	Q9Y6V7	342	367	1	483	Chain	ID=PRO_0000055052;Note=Probable ATP-dependent RNA helicase DDX49
DDX49	Q9Y6V7	342	367	218	382	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX49	Q9Y6V7	342	367	312	361	Alternative sequence	ID=VSP_056368;Note=In isoform 2. LDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVH->ADQPPLPPGAWTSLRYRWSSTTTPPGSPRSTSTESAGRPVQGGRVRPSRW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DDX49	Q9Y6V7	342	367	362	483	Alternative sequence	ID=VSP_056369;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DDX55	Q8NHQ9	36	53	1	600	Chain	ID=PRO_0000252210;Note=ATP-dependent RNA helicase DDX55
DDX55	Q8NHQ9	53	82	1	600	Chain	ID=PRO_0000252210;Note=ATP-dependent RNA helicase DDX55
DDX55	Q8NHQ9	319	349	1	600	Chain	ID=PRO_0000252210;Note=ATP-dependent RNA helicase DDX55
DDX55	Q8NHQ9	36	53	40	223	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX55	Q8NHQ9	53	82	40	223	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX55	Q8NHQ9	319	349	254	402	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX55	Q8NHQ9	36	53	53	60	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX55	Q8NHQ9	53	82	53	60	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX55	Q8NHQ9	36	53	9	37	Motif	Note=Q motif
DDX55	Q8NHQ9	36	53	1	393	Alternative sequence	ID=VSP_056155;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DDX55	Q8NHQ9	53	82	1	393	Alternative sequence	ID=VSP_056155;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DDX55	Q8NHQ9	319	349	1	393	Alternative sequence	ID=VSP_056155;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC34	Q96HJ3	166	202	1	373	Chain	ID=PRO_0000339111;Note=Coiled-coil domain-containing protein 34
CCDC34	Q96HJ3	166	202	152	286	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC34	Q96HJ3	166	202	192	192	Natural variant	ID=VAR_050750;Note=H->N;Dbxref=dbSNP:rs12364852
CCDC57	Q2TAC2	284	350	1	916	Chain	ID=PRO_0000288871;Note=Coiled-coil domain-containing protein 57
CCDC57	Q2TAC2	284	350	1	916	Chain	ID=PRO_0000288871;Note=Coiled-coil domain-containing protein 57
CCDC57	Q2TAC2	284	350	25	487	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC57	Q2TAC2	284	350	25	487	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC57	Q2TAC2	284	350	321	321	Natural variant	ID=VAR_032517;Note=Q->R;Dbxref=dbSNP:rs7406116
CCDC57	Q2TAC2	284	350	321	321	Natural variant	ID=VAR_032517;Note=Q->R;Dbxref=dbSNP:rs7406116
DCDC1	Q6ZRR9	438	495	1	648	Chain	ID=PRO_0000338616;Note=Doublecortin domain-containing protein 5
DCDC1	Q6ZRR9	438	495	491	570	Domain	Note=Doublecortin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00072
CD1D	P15813	202	295	20	335	Chain	ID=PRO_0000014581;Note=Antigen-presenting glycoprotein CD1d
CD1D	P15813	202	295	20	301	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD1D	P15813	202	295	185	292	Domain	Note=Ig-like
CD1D	P15813	202	295	224	279	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1ZT4,ECO:0000244|PDB:2PO6,ECO:0000269|PubMed:16007090,ECO:0000269|PubMed:17581592;Dbxref=PMID:16007090,PMID:17581592
CD1D	P15813	202	295	206	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	215	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	235	240	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZT4
CD1D	P15813	202	295	248	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VWK
CD1D	P15813	202	295	257	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VWJ
CD1D	P15813	202	295	261	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	271	276	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	278	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	284	286	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CD1D	P15813	202	295	291	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WW2
CDC16	Q13042	67	80	1	620	Chain	ID=PRO_0000106267;Note=Cell division cycle protein 16 homolog
CDC16	Q13042	324	365	1	620	Chain	ID=PRO_0000106267;Note=Cell division cycle protein 16 homolog
CDC16	Q13042	366	416	1	620	Chain	ID=PRO_0000106267;Note=Cell division cycle protein 16 homolog
CDC16	Q13042	67	80	1	620	Chain	ID=PRO_0000106267;Note=Cell division cycle protein 16 homolog
CDC16	Q13042	324	365	1	620	Chain	ID=PRO_0000106267;Note=Cell division cycle protein 16 homolog
CDC16	Q13042	366	416	1	620	Chain	ID=PRO_0000106267;Note=Cell division cycle protein 16 homolog
CDC16	Q13042	67	80	70	93	Repeat	Note=TPR 3
CDC16	Q13042	67	80	70	93	Repeat	Note=TPR 3
CDC16	Q13042	324	365	299	329	Repeat	Note=TPR 9
CDC16	Q13042	324	365	299	329	Repeat	Note=TPR 9
CDC16	Q13042	324	365	334	362	Repeat	Note=TPR 10
CDC16	Q13042	324	365	334	362	Repeat	Note=TPR 10
CDC16	Q13042	366	416	369	397	Repeat	Note=TPR 11
CDC16	Q13042	366	416	369	397	Repeat	Note=TPR 11
CDC16	Q13042	366	416	402	434	Repeat	Note=TPR 12
CDC16	Q13042	366	416	402	434	Repeat	Note=TPR 12
CDC16	Q13042	67	80	1	94	Alternative sequence	ID=VSP_057270;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDC16	Q13042	67	80	1	94	Alternative sequence	ID=VSP_057270;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDC16	Q13042	366	416	367	417	Alternative sequence	ID=VSP_008428;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC16	Q13042	366	416	367	417	Alternative sequence	ID=VSP_008428;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC16	Q13042	67	80	65	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC16	Q13042	67	80	65	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC16	Q13042	67	80	71	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC16	Q13042	67	80	71	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC16	Q13042	324	365	316	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	316	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	330	332	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC16	Q13042	324	365	330	332	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC16	Q13042	324	365	335	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	335	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	350	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	350	363	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	324	365	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	364	366	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	369	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	369	380	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	384	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	384	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	402	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDC16	Q13042	366	416	402	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HYM
CDK8	P49336	215	263	1	464	Chain	ID=PRO_0000085797;Note=Cyclin-dependent kinase 8
CDK8	P49336	215	263	21	335	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK8	P49336	215	263	213	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XS2
CDK8	P49336	215	263	249	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XS2
CDT1	Q9H211	374	425	1	546	Chain	ID=PRO_0000191619;Note=DNA replication factor Cdt1
CDT1	Q9H211	374	425	380	380	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CDT1	Q9H211	374	425	394	394	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CDT1	Q9H211	374	425	420	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LE8
CDT1	Q9H211	374	425	425	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LE8
C5orf51	A6NDU8	69	118	2	294	Chain	ID=PRO_0000341214;Note=UPF0600 protein C5orf51
CELA2A	P08217	76	118	29	269	Chain	ID=PRO_0000027694;Note=Chymotrypsin-like elastase family member 2A
CELA2A	P08217	76	118	29	267	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
UGCG	Q16739	246	274	1	394	Chain	ID=PRO_0000059176;Note=Ceramide glucosyltransferase
UGCG	Q16739	246	274	216	287	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
UGCG	Q16739	246	274	272	276	Motif	Note=(Q/R)XXRW;Ontology_term=ECO:0000305;evidence=ECO:0000305
CELF4	Q9BZC1	416	444	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	388	416	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	416	444	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	388	416	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	416	444	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	388	416	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	416	444	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	388	416	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	388	416	388	389	Alternative sequence	ID=VSP_026831;Note=In isoform 2. GP->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CELF4	Q9BZC1	388	416	388	389	Alternative sequence	ID=VSP_026831;Note=In isoform 2. GP->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CELF4	Q9BZC1	416	444	417	444	Alternative sequence	ID=VSP_026832;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10893231,ECO:0000303|PubMed:15489334;Dbxref=PMID:10893231,PMID:15489334
CELF4	Q9BZC1	416	444	417	444	Alternative sequence	ID=VSP_026832;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10893231,ECO:0000303|PubMed:15489334;Dbxref=PMID:10893231,PMID:15489334
CELF4	Q9BZC1	388	416	388	388	Natural variant	ID=VAR_052203;Note=G->S;Dbxref=dbSNP:rs12458669
CELF4	Q9BZC1	388	416	388	388	Natural variant	ID=VAR_052203;Note=G->S;Dbxref=dbSNP:rs12458669
CEBPZ	Q03701	718	736	1	1054	Chain	ID=PRO_0000173470;Note=CCAAT/enhancer-binding protein zeta
CENPF	P49454	1662	2610	1	3207	Chain	ID=PRO_0000089477;Note=Centromere protein F
CENPF	P49454	2661	2720	1	3207	Chain	ID=PRO_0000089477;Note=Centromere protein F
CENPF	P49454	1662	2610	2207	2386	Repeat	Note=2-1
CENPF	P49454	1662	2610	2389	2568	Repeat	Note=2-2
CENPF	P49454	1662	2610	2122	2447	Region	Note=Interaction with NDE1 and NDEL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17600710;Dbxref=PMID:17600710
CENPF	P49454	1662	2610	2207	2568	Region	Note=2 X 177 AA tandem repeats
CENPF	P49454	1662	2610	2488	3113	Region	Note=Sufficient for centromere localization
CENPF	P49454	2661	2720	2488	3113	Region	Note=Sufficient for centromere localization
CENPF	P49454	1662	2610	2488	2925	Region	Note=Sufficient for self-association
CENPF	P49454	2661	2720	2488	2925	Region	Note=Sufficient for self-association
CENPF	P49454	1662	2610	1642	1746	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPF	P49454	1662	2610	1862	2987	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPF	P49454	2661	2720	1862	2987	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPF	P49454	1662	2610	1747	1747	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
CENPF	P49454	1662	2610	1748	1748	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CENPF	P49454	1662	2610	1750	1750	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
CENPF	P49454	1662	2610	1822	1822	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CENPF	P49454	1662	2610	1958	1958	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CENPF	P49454	1662	2610	1964	1964	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CENPF	P49454	1662	2610	1988	1988	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
CENPF	P49454	1662	2610	2512	2512	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CENPF	P49454	1662	2610	2513	2513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
CENPF	P49454	1662	2610	1864	1864	Natural variant	ID=VAR_055638;Note=D->N;Dbxref=dbSNP:rs3748692
CENPF	P49454	1662	2610	2011	2011	Natural variant	ID=VAR_034723;Note=E->A;Dbxref=dbSNP:rs3790647
CENPF	P49454	1662	2610	1811	1811	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPF	P49454	1662	2610	2242	2243	Sequence conflict	Note=ER->DG;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPF	P49454	1662	2610	2335	2335	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPF	P49454	1662	2610	2492	2492	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPF	P49454	1662	2610	2492	2492	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPF	P49454	1662	2610	2545	2561	Sequence conflict	Note=ELNERVAALHNDQEACK->SSMREWQPCIMTKKPVS;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPI	Q92674	229	259	1	756	Chain	ID=PRO_0000087354;Note=Centromere protein I
CENPI	Q92674	698	712	1	756	Chain	ID=PRO_0000087354;Note=Centromere protein I
CENPI	Q92674	229	259	1	756	Chain	ID=PRO_0000087354;Note=Centromere protein I
CENPI	Q92674	698	712	1	756	Chain	ID=PRO_0000087354;Note=Centromere protein I
CENPI	Q92674	698	712	523	756	Alternative sequence	ID=VSP_015797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CENPI	Q92674	698	712	523	756	Alternative sequence	ID=VSP_015797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CERK	Q8TCT0	85	126	1	537	Chain	ID=PRO_0000181354;Note=Ceramide kinase
CERK	Q8TCT0	85	126	1	125	Region	Note=Required for binding to sulfatide and phosphoinositides
CERK	Q8TCT0	85	126	1	198	Alternative sequence	ID=VSP_056944;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C7orf31	Q8N865	128	137	1	590	Chain	ID=PRO_0000089587;Note=Uncharacterized protein C7orf31
C7orf31	Q8N865	104	127	1	590	Chain	ID=PRO_0000089587;Note=Uncharacterized protein C7orf31
C7orf31	Q8N865	45	103	1	590	Chain	ID=PRO_0000089587;Note=Uncharacterized protein C7orf31
C7orf31	Q8N865	128	137	1	590	Chain	ID=PRO_0000089587;Note=Uncharacterized protein C7orf31
C7orf31	Q8N865	104	127	1	590	Chain	ID=PRO_0000089587;Note=Uncharacterized protein C7orf31
C7orf31	Q8N865	45	103	1	590	Chain	ID=PRO_0000089587;Note=Uncharacterized protein C7orf31
C7orf31	Q8N865	45	103	82	82	Natural variant	ID=VAR_022781;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2717858,PMID:15489334
C7orf31	Q8N865	45	103	82	82	Natural variant	ID=VAR_022781;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2717858,PMID:15489334
C7orf31	Q8N865	45	103	86	86	Natural variant	ID=VAR_056810;Note=R->C;Dbxref=dbSNP:rs3213642
C7orf31	Q8N865	45	103	86	86	Natural variant	ID=VAR_056810;Note=R->C;Dbxref=dbSNP:rs3213642
DCSTAMP	Q9H295	343	446	1	470	Chain	ID=PRO_0000072584;Note=Dendritic cell-specific transmembrane protein
DCSTAMP	Q9H295	343	446	314	376	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCSTAMP	Q9H295	343	446	377	397	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCSTAMP	Q9H295	343	446	398	470	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11169400;Dbxref=PMID:11169400
DCSTAMP	Q9H295	343	446	284	470	Alternative sequence	ID=VSP_044788;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DCSTAMP	Q9H295	343	446	349	349	Natural variant	ID=VAR_051438;Note=D->G;Dbxref=dbSNP:rs3802204
CTH	P32929	83	115	1	405	Chain	ID=PRO_0000114749;Note=Cystathionine gamma-lyase
CTH	P32929	152	196	1	405	Chain	ID=PRO_0000114749;Note=Cystathionine gamma-lyase
CTH	P32929	83	115	114	114	Binding site	Note=Substrate
CTH	P32929	83	115	85	116	Alternative sequence	ID=VSP_047274;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CTH	P32929	152	196	153	196	Alternative sequence	ID=VSP_006306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1339280;Dbxref=PMID:1339280
CTH	P32929	83	115	82	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	83	115	90	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	83	115	106	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	83	115	115	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	151	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	169	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	183	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	189	191	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
CTH	P32929	152	196	193	195	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3COG
HSPD1	P10809	170	202	27	573	Chain	ID=PRO_0000005026;Note=60 kDa heat shock protein%2C mitochondrial
HSPD1	P10809	170	202	27	573	Chain	ID=PRO_0000005026;Note=60 kDa heat shock protein%2C mitochondrial
HSPD1	P10809	170	202	191	191	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63038
HSPD1	P10809	170	202	191	191	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63038
HSPD1	P10809	170	202	191	191	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63038
HSPD1	P10809	170	202	191	191	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63038
HSPD1	P10809	170	202	202	202	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HSPD1	P10809	170	202	202	202	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
HSPD1	P10809	170	202	202	202	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63038
HSPD1	P10809	170	202	202	202	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63038
HSPD1	P10809	170	202	159	573	Alternative sequence	ID=VSP_056145;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPD1	P10809	170	202	159	573	Alternative sequence	ID=VSP_056145;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HSPD1	P10809	170	202	177	177	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPD1	P10809	170	202	177	177	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPD1	P10809	170	202	202	202	Sequence conflict	Note=K->KAS;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPD1	P10809	170	202	202	202	Sequence conflict	Note=K->KAS;Ontology_term=ECO:0000305;evidence=ECO:0000305
HSPD1	P10809	170	202	165	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	165	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	176	178	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	180	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	180	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	197	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
HSPD1	P10809	170	202	197	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ1
DDX50	Q9BQ39	413	467	1	737	Chain	ID=PRO_0000055054;Note=ATP-dependent RNA helicase DDX50
DDX50	Q9BQ39	585	630	1	737	Chain	ID=PRO_0000055054;Note=ATP-dependent RNA helicase DDX50
DDX50	Q9BQ39	413	467	380	524	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX50	Q9BQ39	585	630	587	593	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E29
DDX50	Q9BQ39	585	630	602	611	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E29
DDX50	Q9BQ39	585	630	614	617	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E29
DDX50	Q9BQ39	585	630	621	625	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E29
DDX50	Q9BQ39	585	630	629	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E29
DEF6	Q9H4E7	79	141	1	631	Chain	ID=PRO_0000294522;Note=Differentially expressed in FDCP 6 homolog
DEF6	Q9H4E7	220	269	1	631	Chain	ID=PRO_0000294522;Note=Differentially expressed in FDCP 6 homolog
DEF6	Q9H4E7	220	269	216	312	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
DEF6	Q9H4E7	220	269	225	225	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DEF6	Q9H4E7	220	269	225	226	Mutagenesis	Note=Abolishes PtdInsP3 binding. KR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17121847;Dbxref=PMID:17121847
DEF6	Q9H4E7	220	269	230	231	Mutagenesis	Note=Abolishes PtdInsP3 binding. RR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17121847;Dbxref=PMID:17121847
DEF6	Q9H4E7	220	269	236	236	Mutagenesis	Note=Abolishes PtdInsP3 binding. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12923183;Dbxref=PMID:12923183
C11orf65	Q8NCR3	58	76	1	313	Chain	ID=PRO_0000263665;Note=Uncharacterized protein C11orf65
C11orf65	Q8NCR3	27	58	1	313	Chain	ID=PRO_0000263665;Note=Uncharacterized protein C11orf65
C11orf65	Q8NCR3	58	76	1	313	Chain	ID=PRO_0000263665;Note=Uncharacterized protein C11orf65
C11orf65	Q8NCR3	27	58	1	313	Chain	ID=PRO_0000263665;Note=Uncharacterized protein C11orf65
C11orf65	Q8NCR3	58	76	28	76	Alternative sequence	ID=VSP_056888;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C11orf65	Q8NCR3	27	58	28	76	Alternative sequence	ID=VSP_056888;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C11orf65	Q8NCR3	58	76	28	76	Alternative sequence	ID=VSP_056888;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C11orf65	Q8NCR3	27	58	28	76	Alternative sequence	ID=VSP_056888;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CMTM2	Q8TAZ6	95	148	1	248	Chain	ID=PRO_0000186098;Note=CKLF-like MARVEL transmembrane domain-containing protein 2
CMTM2	Q8TAZ6	95	148	116	136	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM2	Q8TAZ6	95	148	147	167	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM2	Q8TAZ6	95	148	82	204	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM2	Q8TAZ6	95	148	96	148	Alternative sequence	ID=VSP_047061;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15896670;Dbxref=PMID:15896670
CMTM2	Q8TAZ6	95	148	122	122	Natural variant	ID=VAR_022154;Note=I->T;Dbxref=dbSNP:rs2290182
CMTM5	Q96DZ9	93	160	1	223	Chain	ID=PRO_0000186105;Note=CKLF-like MARVEL transmembrane domain-containing protein 5
CMTM5	Q96DZ9	93	160	29	213	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM5	Q96DZ9	93	160	43	191	Alternative sequence	ID=VSP_008264;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM5	Q96DZ9	93	160	43	160	Alternative sequence	ID=VSP_008263;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM5	Q96DZ9	93	160	94	191	Alternative sequence	ID=VSP_047120;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12782130;Dbxref=PMID:12782130
CMTM5	Q96DZ9	93	160	94	160	Alternative sequence	ID=VSP_008265;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12782130,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:12782130,PMID:15489334
C12orf29	Q8N999	140	206	1	325	Chain	ID=PRO_0000305272;Note=Uncharacterized protein C12orf29
C12orf29	Q8N999	140	206	39	325	Alternative sequence	ID=VSP_028318;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
C12orf29	Q8N999	140	206	140	140	Alternative sequence	ID=VSP_028319;Note=In isoform 3. P->PG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
C12orf42	Q96LP6	86	210	1	360	Chain	ID=PRO_0000274274;Note=Uncharacterized protein C12orf42
C12orf42	Q96LP6	86	210	1	360	Chain	ID=PRO_0000274274;Note=Uncharacterized protein C12orf42
C12orf42	Q96LP6	86	210	1	95	Alternative sequence	ID=VSP_022691;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C12orf42	Q96LP6	86	210	1	95	Alternative sequence	ID=VSP_022691;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C12orf42	Q96LP6	86	210	87	107	Alternative sequence	ID=VSP_022692;Note=In isoform 3. VFPERTQNSMACKRLLHTCQY->GSHHGQATQKLQGAMVLHLEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C12orf42	Q96LP6	86	210	87	107	Alternative sequence	ID=VSP_022692;Note=In isoform 3. VFPERTQNSMACKRLLHTCQY->GSHHGQATQKLQGAMVLHLEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C12orf42	Q96LP6	86	210	108	360	Alternative sequence	ID=VSP_022693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C12orf42	Q96LP6	86	210	108	360	Alternative sequence	ID=VSP_022693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C12orf42	Q96LP6	86	210	182	182	Natural variant	ID=VAR_030230;Note=P->R;Dbxref=dbSNP:rs7484376
C12orf42	Q96LP6	86	210	182	182	Natural variant	ID=VAR_030230;Note=P->R;Dbxref=dbSNP:rs7484376
CLEC4C	Q8WTT0	41	78	1	213	Chain	ID=PRO_0000046615;Note=C-type lectin domain family 4 member C
CLEC4C	Q8WTT0	10	41	1	213	Chain	ID=PRO_0000046615;Note=C-type lectin domain family 4 member C
CLEC4C	Q8WTT0	41	78	1	213	Chain	ID=PRO_0000046615;Note=C-type lectin domain family 4 member C
CLEC4C	Q8WTT0	10	41	1	213	Chain	ID=PRO_0000046615;Note=C-type lectin domain family 4 member C
CLEC4C	Q8WTT0	10	41	1	21	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	10	41	1	21	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	41	78	22	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	10	41	22	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	41	78	22	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	10	41	22	44	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	41	78	45	213	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	41	78	45	213	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4C	Q8WTT0	41	78	70	82	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZES,ECO:0000244|PDB:4ZET,ECO:0000269|PubMed:25995448;Dbxref=PMID:25995448
CLEC4C	Q8WTT0	41	78	70	82	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZES,ECO:0000244|PDB:4ZET,ECO:0000269|PubMed:25995448;Dbxref=PMID:25995448
CLEC4C	Q8WTT0	41	78	11	41	Alternative sequence	ID=VSP_012845;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11536172;Dbxref=PMID:11536172
CLEC4C	Q8WTT0	10	41	11	41	Alternative sequence	ID=VSP_012845;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11536172;Dbxref=PMID:11536172
CLEC4C	Q8WTT0	41	78	11	41	Alternative sequence	ID=VSP_012845;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11536172;Dbxref=PMID:11536172
CLEC4C	Q8WTT0	10	41	11	41	Alternative sequence	ID=VSP_012845;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11536172;Dbxref=PMID:11536172
CLEC4C	Q8WTT0	41	78	66	66	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC4C	Q8WTT0	41	78	66	66	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC4C	Q8WTT0	41	78	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZES
CLEC4C	Q8WTT0	41	78	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZES
CLEC4F	Q8N1N0	59	89	1	589	Chain	ID=PRO_0000046622;Note=C-type lectin domain family 4 member F
CLEC4F	Q8N1N0	59	89	40	60	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4F	Q8N1N0	59	89	61	589	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC4F	Q8N1N0	59	89	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLCNKB	P51801	432	469	1	687	Chain	ID=PRO_0000094459;Note=Chloride channel protein ClC-Kb
CLCNKB	P51801	643	672	1	687	Chain	ID=PRO_0000094459;Note=Chloride channel protein ClC-Kb
CLCNKB	P51801	432	469	417	437	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLCNKB	P51801	432	469	452	472	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLCNKB	P51801	643	672	626	684	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCNKB	P51801	432	469	432	432	Natural variant	ID=VAR_001627;Note=In BARTS3. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909135,PMID:9326936
CLCNKB	P51801	432	469	438	438	Natural variant	ID=VAR_001628;Note=In BARTS3. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909133,PMID:9326936
CLCNKB	P51801	643	672	660	660	Natural variant	ID=VAR_046801;Note=S->L;Dbxref=dbSNP:rs5255
CLNK	Q7Z7G1	164	200	1	428	Chain	ID=PRO_0000314597;Note=Cytokine-dependent hematopoietic cell linker
CLNK	Q7Z7G1	4	27	1	428	Chain	ID=PRO_0000314597;Note=Cytokine-dependent hematopoietic cell linker
CLNK	Q7Z7G1	164	200	159	164	Region	Note=Mediates interaction with PLCG1;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLNK	Q7Z7G1	164	200	178	180	Region	Note=Mediates interaction with LAT and GRB2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLNK	Q7Z7G1	164	200	159	186	Compositional bias	Note=Pro-rich
CLNK	Q7Z7G1	4	27	1	42	Alternative sequence	ID=VSP_030330;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLNK	Q7Z7G1	164	200	147	183	Alternative sequence	ID=VSP_030331;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLNK	Q7Z7G1	164	200	198	198	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLNK	Q7Z7G1	164	200	198	198	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC25A12	O75746	408	435	2	678	Chain	ID=PRO_0000090598;Note=Calcium-binding mitochondrial carrier protein Aralar1
SLC25A12	O75746	337	390	2	678	Chain	ID=PRO_0000090598;Note=Calcium-binding mitochondrial carrier protein Aralar1
SLC25A12	O75746	337	390	330	347	Transmembrane	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:9722566;Dbxref=PMID:9722566
SLC25A12	O75746	408	435	391	410	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:9722566;Dbxref=PMID:9722566
SLC25A12	O75746	408	435	434	447	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:9722566;Dbxref=PMID:9722566
SLC25A12	O75746	408	435	324	416	Repeat	Note=Solcar 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00282
SLC25A12	O75746	337	390	324	416	Repeat	Note=Solcar 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00282
SLC25A12	O75746	408	435	424	508	Repeat	Note=Solcar 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00282
SLC25A12	O75746	408	435	320	612	Region	Note=Carrier domain;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:25410934;Dbxref=PMID:25410934
SLC25A12	O75746	337	390	320	612	Region	Note=Carrier domain;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:25410934;Dbxref=PMID:25410934
SLC25A12	O75746	337	390	353	353	Natural variant	ID=VAR_071976;Note=In EIEE39%3B significant loss in ability to transport aspartate or glutamate. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24515575;Dbxref=dbSNP:rs886037851,PMID:24515575
CLUAP1	Q96AJ1	73	133	1	413	Chain	ID=PRO_0000239451;Note=Clusterin-associated protein 1
CLUAP1	Q96AJ1	133	165	1	413	Chain	ID=PRO_0000239451;Note=Clusterin-associated protein 1
CLUAP1	Q96AJ1	73	133	1	166	Alternative sequence	ID=VSP_019229;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLUAP1	Q96AJ1	133	165	1	166	Alternative sequence	ID=VSP_019229;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHI3L1	P36222	8	18	1	21	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2375755,ECO:0000269|PubMed:9492324;Dbxref=PMID:2375755,PMID:9492324
CHI3L1	P36222	298	337	22	383	Chain	ID=PRO_0000011965;Note=Chitinase-3-like protein 1
CHI3L1	P36222	237	298	22	383	Chain	ID=PRO_0000011965;Note=Chitinase-3-like protein 1
CHI3L1	P36222	86	104	22	383	Chain	ID=PRO_0000011965;Note=Chitinase-3-like protein 1
CHI3L1	P36222	86	104	97	100	Region	Note=Chitooligosaccharide binding
CHI3L1	P36222	298	337	324	338	Region	Note=Important for AKT1 activation and IL8 production;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHI3L1	P36222	237	298	263	263	Binding site	Note=Chitooligosaccharide
CHI3L1	P36222	298	337	300	364	Disulfide bond	.
CHI3L1	P36222	298	337	311	311	Natural variant	ID=VAR_019839;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8245017,ECO:0000269|PubMed:9244440;Dbxref=dbSNP:rs1049407,PMID:8245017,PMID:9244440
CHI3L1	P36222	86	104	91	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	86	104	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	86	104	103	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	237	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	251	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	254	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	277	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	286	288	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	296	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	237	298	296	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	303	305	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	307	310	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	312	314	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	317	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	324	327	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
CHI3L1	P36222	298	337	331	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HJX
DDX58	O95786	779	827	1	925	Chain	ID=PRO_0000144093;Note=Probable ATP-dependent RNA helicase DDX58
DDX58	O95786	671	728	1	925	Chain	ID=PRO_0000144093;Note=Probable ATP-dependent RNA helicase DDX58
DDX58	O95786	458	493	1	925	Chain	ID=PRO_0000144093;Note=Probable ATP-dependent RNA helicase DDX58
DDX58	O95786	35	80	1	925	Chain	ID=PRO_0000144093;Note=Probable ATP-dependent RNA helicase DDX58
DDX58	O95786	35	80	1	87	Domain	Note=CARD 1
DDX58	O95786	671	728	610	776	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX58	O95786	779	827	794	925	Domain	Note=RLR CTR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01125
DDX58	O95786	779	827	218	925	Region	Note=Interaction with ZC3HAV1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21102435;Dbxref=PMID:21102435
DDX58	O95786	671	728	218	925	Region	Note=Interaction with ZC3HAV1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21102435;Dbxref=PMID:21102435
DDX58	O95786	458	493	218	925	Region	Note=Interaction with ZC3HAV1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21102435;Dbxref=PMID:21102435
DDX58	O95786	779	827	810	810	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01125
DDX58	O95786	779	827	813	813	Metal binding	Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01125
DDX58	O95786	779	827	812	812	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6Q899
DDX58	O95786	35	80	36	80	Alternative sequence	ID=VSP_016054;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DDX58	O95786	35	80	55	55	Mutagenesis	Note=No IRF3 signaling activity%3B no effect on dsRNA binding. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15708988;Dbxref=PMID:15708988
DDX58	O95786	35	80	35	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P4H
DDX58	O95786	35	80	50	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P4H
DDX58	O95786	35	80	69	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P4H
DDX58	O95786	458	493	457	462	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKG
DDX58	O95786	458	493	470	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKG
DDX58	O95786	458	493	493	495	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKG
DDX58	O95786	671	728	675	683	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9F
DDX58	O95786	671	728	686	690	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9F
DDX58	O95786	671	728	694	700	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKG
DDX58	O95786	671	728	701	703	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ON9
DDX58	O95786	671	728	706	708	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZD7
DDX58	O95786	671	728	710	716	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKG
DDX58	O95786	671	728	721	726	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9F
DDX58	O95786	671	728	727	731	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F9F
DDX58	O95786	779	827	773	793	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YKG
DDX58	O95786	779	827	801	804	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RMJ
DDX58	O95786	779	827	806	810	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRR
DDX58	O95786	779	827	811	813	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRR
DDX58	O95786	779	827	816	819	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRR
DDX58	O95786	779	827	820	822	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRR
DDX58	O95786	779	827	823	826	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRR
DDX58	O95786	779	827	827	829	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LRR
DDX5	P17844	405	480	1	614	Chain	ID=PRO_0000054991;Note=Probable ATP-dependent RNA helicase DDX5
DDX5	P17844	385	405	1	614	Chain	ID=PRO_0000054991;Note=Probable ATP-dependent RNA helicase DDX5
DDX5	P17844	328	364	1	614	Chain	ID=PRO_0000054991;Note=Probable ATP-dependent RNA helicase DDX5
DDX5	P17844	147	169	1	614	Chain	ID=PRO_0000054991;Note=Probable ATP-dependent RNA helicase DDX5
DDX5	P17844	147	169	125	300	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX5	P17844	405	480	328	475	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX5	P17844	385	405	328	475	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX5	P17844	328	364	328	475	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX5	P17844	405	480	477	614	Region	Note=Transactivation domain
DDX5	P17844	405	480	480	480	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
DDX5	P17844	328	364	340	340	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	328	364	343	343	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	385	405	388	388	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	385	405	391	391	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	405	480	411	411	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	405	480	437	437	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	405	480	451	451	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	405	480	470	470	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX5	P17844	147	169	85	163	Alternative sequence	ID=VSP_056154;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX5	P17844	405	480	480	480	Natural variant	ID=VAR_029241;Note=S->A;Dbxref=dbSNP:rs1140409
DDX5	P17844	385	405	403	403	Mutagenesis	Note=Binds to the tau stem-loop-containing RNA. Inhibits tau exon 10 inclusion and RNA cleavage. Does not inhibit interaction with RBM4. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343338;Dbxref=PMID:21343338
DDX5	P17844	147	169	144	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE2
DDX5	P17844	147	169	169	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FE2
DEF8	Q6ZN54	330	368	1	512	Chain	ID=PRO_0000321913;Note=Differentially expressed in FDCP 8 homolog
DEF8	Q6ZN54	368	395	1	512	Chain	ID=PRO_0000321913;Note=Differentially expressed in FDCP 8 homolog
DEF8	Q6ZN54	330	368	259	512	Alternative sequence	ID=VSP_031824;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DEF8	Q6ZN54	368	395	259	512	Alternative sequence	ID=VSP_031824;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DEF8	Q6ZN54	368	395	395	411	Alternative sequence	ID=VSP_047179;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CMTM6	Q9NX76	105	138	1	183	Chain	ID=PRO_0000186107;Note=CKLF-like MARVEL transmembrane domain-containing protein 6
CMTM6	Q9NX76	105	138	89	106	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28813410;Dbxref=PMID:28813410
CMTM6	Q9NX76	105	138	107	127	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM6	Q9NX76	105	138	128	134	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:28813410;Dbxref=PMID:28813410
CMTM6	Q9NX76	105	138	135	155	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM6	Q9NX76	105	138	33	160	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
DENND3	A2RUS2	205	278	1	1198	Chain	ID=PRO_0000304672;Note=DENN domain-containing protein 3
DENND3	A2RUS2	319	370	1	1198	Chain	ID=PRO_0000304672;Note=DENN domain-containing protein 3
DENND3	A2RUS2	504	678	1	1198	Chain	ID=PRO_0000304672;Note=DENN domain-containing protein 3
DENND3	A2RUS2	205	278	186	318	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND3	A2RUS2	319	370	320	424	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND3	A2RUS2	504	678	438	888	Region	Note=Linker;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND3	A2RUS2	205	278	1	950	Alternative sequence	ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DENND3	A2RUS2	319	370	1	950	Alternative sequence	ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DENND3	A2RUS2	504	678	1	950	Alternative sequence	ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DENND3	A2RUS2	205	278	129	1198	Alternative sequence	ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DENND3	A2RUS2	319	370	129	1198	Alternative sequence	ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DENND3	A2RUS2	504	678	129	1198	Alternative sequence	ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DENND3	A2RUS2	319	370	319	370	Alternative sequence	ID=VSP_028080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DENND3	A2RUS2	319	370	364	364	Natural variant	ID=VAR_035054;Note=Q->R;Dbxref=dbSNP:rs11997191
C12orf54	Q6X4T0	45	56	1	127	Chain	ID=PRO_0000274305;Note=Uncharacterized protein C12orf54
CLCA1	A8K7I4	245	318	22	914	Chain	ID=PRO_0000333690;Note=Calcium-activated chloride channel regulator 1
CLCA1	A8K7I4	318	394	22	914	Chain	ID=PRO_0000333690;Note=Calcium-activated chloride channel regulator 1
CLCA1	A8K7I4	245	318	22	914	Chain	ID=PRO_0000333690;Note=Calcium-activated chloride channel regulator 1
CLCA1	A8K7I4	318	394	22	914	Chain	ID=PRO_0000333690;Note=Calcium-activated chloride channel regulator 1
CLCA1	A8K7I4	245	318	306	475	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CLCA1	A8K7I4	318	394	306	475	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CLCA1	A8K7I4	245	318	306	475	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CLCA1	A8K7I4	318	394	306	475	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
CLCA1	A8K7I4	318	394	357	357	Natural variant	ID=VAR_043146;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10437792,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9828122,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2734705,PMID:10437792,PMID:14702039,PMID:9828122
CLCA1	A8K7I4	318	394	357	357	Natural variant	ID=VAR_043146;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10437792,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9828122,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2734705,PMID:10437792,PMID:14702039,PMID:9828122
CLCA1	A8K7I4	318	394	393	393	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLCA1	A8K7I4	318	394	393	393	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC18A	A5D8T8	72	152	27	446	Chain	ID=PRO_0000324316;Note=C-type lectin domain family 18 member A
CLEC18A	A5D8T8	72	152	27	446	Chain	ID=PRO_0000324316;Note=C-type lectin domain family 18 member A
CLEC18A	A5D8T8	72	152	27	446	Chain	ID=PRO_0000324316;Note=C-type lectin domain family 18 member A
CLEC18A	A5D8T8	72	152	52	182	Domain	Note=SCP
CLEC18A	A5D8T8	72	152	52	182	Domain	Note=SCP
CLEC18A	A5D8T8	72	152	52	182	Domain	Note=SCP
CLEC18A	A5D8T8	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18A	A5D8T8	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18A	A5D8T8	72	152	144	144	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC18A	A5D8T8	72	152	1	340	Alternative sequence	ID=VSP_032204;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLEC18A	A5D8T8	72	152	1	340	Alternative sequence	ID=VSP_032204;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLEC18A	A5D8T8	72	152	1	340	Alternative sequence	ID=VSP_032204;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLEC18A	A5D8T8	72	152	118	118	Natural variant	ID=VAR_059449;Note=In allele CLEC18A-1. V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26170455,ECO:0000269|Ref.1;Dbxref=dbSNP:rs2549097,PMID:14702039,PMID:15489334,PMID:26170455
CLEC18A	A5D8T8	72	152	118	118	Natural variant	ID=VAR_059449;Note=In allele CLEC18A-1. V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26170455,ECO:0000269|Ref.1;Dbxref=dbSNP:rs2549097,PMID:14702039,PMID:15489334,PMID:26170455
CLEC18A	A5D8T8	72	152	118	118	Natural variant	ID=VAR_059449;Note=In allele CLEC18A-1. V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26170455,ECO:0000269|Ref.1;Dbxref=dbSNP:rs2549097,PMID:14702039,PMID:15489334,PMID:26170455
CLEC18A	A5D8T8	72	152	151	151	Natural variant	ID=VAR_074610;Note=In allele CLEC18A-1. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26170455;Dbxref=dbSNP:rs75776403,PMID:14702039,PMID:15489334,PMID:26170455
CLEC18A	A5D8T8	72	152	151	151	Natural variant	ID=VAR_074610;Note=In allele CLEC18A-1. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26170455;Dbxref=dbSNP:rs75776403,PMID:14702039,PMID:15489334,PMID:26170455
CLEC18A	A5D8T8	72	152	151	151	Natural variant	ID=VAR_074610;Note=In allele CLEC18A-1. T->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26170455;Dbxref=dbSNP:rs75776403,PMID:14702039,PMID:15489334,PMID:26170455
CLPX	O76031	537	568	57	633	Chain	ID=PRO_0000005518;Note=ATP-dependent Clp protease ATP-binding subunit clpX-like%2C mitochondrial
CLPX	O76031	224	238	57	633	Chain	ID=PRO_0000005518;Note=ATP-dependent Clp protease ATP-binding subunit clpX-like%2C mitochondrial
GAD1	Q99259	334	373	1	594	Chain	ID=PRO_0000146963;Note=Glutamate decarboxylase 1
GAD1	Q99259	471	507	1	594	Chain	ID=PRO_0000146963;Note=Glutamate decarboxylase 1
GAD1	Q99259	334	373	225	594	Alternative sequence	ID=VSP_009124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10671565,ECO:0000303|PubMed:15489334;Dbxref=PMID:10671565,PMID:15489334
GAD1	Q99259	471	507	225	594	Alternative sequence	ID=VSP_009124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10671565,ECO:0000303|PubMed:15489334;Dbxref=PMID:10671565,PMID:15489334
GAD1	Q99259	471	507	426	594	Alternative sequence	ID=VSP_054474;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GAD1	Q99259	471	507	474	474	Natural variant	ID=VAR_011882;Note=V->G;Dbxref=dbSNP:rs769403
GAD1	Q99259	471	507	477	477	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
GAD1	Q99259	471	507	492	492	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
GAD1	Q99259	334	373	337	346	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VP6
GAD1	Q99259	334	373	348	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VP6
GAD1	Q99259	334	373	356	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VP6
GAD1	Q99259	334	373	369	374	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VP6
GAD1	Q99259	471	507	461	495	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VP6
GAD1	Q99259	471	507	500	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VP6
C7orf26	Q96N11	193	369	1	449	Chain	ID=PRO_0000089582;Note=Uncharacterized protein C7orf26
C7orf26	Q96N11	193	369	215	292	Alternative sequence	ID=VSP_007908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
C7orf26	Q96N11	193	369	245	245	Natural variant	ID=VAR_061593;Note=R->C;Dbxref=dbSNP:rs35534502
CFTR	P13569	403	464	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	464	528	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	560	588	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	830	873	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	1046	1122	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	1156	1239	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	1291	1321	1	1480	Chain	ID=PRO_0000093419;Note=Cystic fibrosis transmembrane conductance regulator
CFTR	P13569	403	464	359	858	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	464	528	359	858	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	560	588	359	858	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	830	873	359	858	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	830	873	859	879	Transmembrane	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	1046	1122	1035	1095	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	1046	1122	1096	1116	Transmembrane	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	1046	1122	1117	1130	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	1156	1239	1152	1480	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	1291	1321	1152	1480	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.54
CFTR	P13569	403	464	423	646	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
CFTR	P13569	464	528	423	646	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
CFTR	P13569	560	588	423	646	Domain	Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
CFTR	P13569	830	873	859	1155	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
CFTR	P13569	1046	1122	859	1155	Domain	Note=ABC transmembrane type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441
CFTR	P13569	1156	1239	1210	1443	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
CFTR	P13569	1291	1321	1210	1443	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
CFTR	P13569	403	464	458	465	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:1XMI,ECO:0000244|PDB:1XMJ,ECO:0000244|PDB:2BBO,ECO:0000244|PDB:2BBS,ECO:0000244|PDB:2BBT,ECO:0000255|PROSITE-ProRule:PRU00434,ECO:0000269|PubMed:15528182;Dbxref=PMID:15528182
CFTR	P13569	464	528	458	465	Nucleotide binding	Note=ATP 1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:1XMI,ECO:0000244|PDB:1XMJ,ECO:0000244|PDB:2BBO,ECO:0000244|PDB:2BBS,ECO:0000244|PDB:2BBT,ECO:0000255|PROSITE-ProRule:PRU00434,ECO:0000269|PubMed:15528182;Dbxref=PMID:15528182
CFTR	P13569	830	873	654	831	Region	Note=Intrinsically disordered R region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10792060;Dbxref=PMID:10792060
CFTR	P13569	403	464	434	434	Binding site	Note=ATP 1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2PZE,ECO:0000244|PDB:2PZF,ECO:0000244|PDB:2PZG,ECO:0000269|PubMed:20150177;Dbxref=PMID:20150177
CFTR	P13569	464	528	493	493	Binding site	Note=ATP 1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1XMI,ECO:0000244|PDB:2BBO,ECO:0000244|PDB:2BBS,ECO:0000269|PubMed:15528182;Dbxref=PMID:15528182
CFTR	P13569	1156	1239	1219	1219	Binding site	Note=ATP 2;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	464	528	524	524	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22119790;Dbxref=PMID:22119790
CFTR	P13569	403	464	404	464	Alternative sequence	ID=VSP_022123;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	464	528	404	464	Alternative sequence	ID=VSP_022123;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	830	873	606	1480	Alternative sequence	ID=VSP_022125;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	1046	1122	606	1480	Alternative sequence	ID=VSP_022125;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	1156	1239	606	1480	Alternative sequence	ID=VSP_022125;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	1291	1321	606	1480	Alternative sequence	ID=VSP_022125;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	403	464	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	464	528	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	560	588	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	830	873	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	1046	1122	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	1156	1239	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	1291	1321	220	1480	Natural variant	ID=VAR_080302;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691141;Dbxref=PMID:20691141
CFTR	P13569	403	464	443	443	Natural variant	ID=VAR_080304;Note=In CBAVD%3B unknown pathological significance. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17329263;Dbxref=dbSNP:rs147422190,PMID:17329263
CFTR	P13569	403	464	455	455	Natural variant	ID=VAR_000160;Note=In CF. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9401006;Dbxref=dbSNP:rs74551128,PMID:9401006
CFTR	P13569	403	464	456	456	Natural variant	ID=VAR_000161;Note=In CF. V->F;Dbxref=dbSNP:rs397508195
CFTR	P13569	403	464	458	458	Natural variant	ID=VAR_000162;Note=In CF. G->V;Dbxref=dbSNP:rs121909009
CFTR	P13569	464	528	467	467	Natural variant	ID=VAR_000163;Note=L->F;Dbxref=dbSNP:rs1800089
CFTR	P13569	464	528	470	470	Natural variant	ID=VAR_000164;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10651488,ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:1710598,ECO:0000269|PubMed:17329263,ECO:0000269|PubMed:18987736,ECO:0000269|PubMed:20691141,ECO:0000269|PubMed:2475911,ECO:0000269|Ref.3;Dbxref=dbSNP:rs213950,PMID:10651488,PMID:1379210,PMID:1710598,PMID:17329263,PMID:18987736,PMID:20691141,PMID:2475911
CFTR	P13569	464	528	480	480	Natural variant	ID=VAR_000165;Note=In CF. G->C;Dbxref=dbSNP:rs79282516
CFTR	P13569	464	528	492	492	Natural variant	ID=VAR_000166;Note=In CF. S->F;Dbxref=dbSNP:rs121909017
CFTR	P13569	464	528	504	504	Natural variant	ID=VAR_000167;Note=In CF. E->Q;Dbxref=dbSNP:rs397508223
CFTR	P13569	464	528	506	506	Natural variant	ID=VAR_009901;Note=I->M;Dbxref=dbSNP:rs1800092
CFTR	P13569	464	528	506	506	Natural variant	ID=VAR_000168;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:9921909;Dbxref=dbSNP:rs1800091,PMID:1379210,PMID:9921909
CFTR	P13569	464	528	507	507	Natural variant	ID=VAR_000169;Note=I->V;Dbxref=dbSNP:rs1800091
CFTR	P13569	464	528	507	507	Natural variant	ID=VAR_000170;Note=In CF%3B impaired maturation of glycan chains. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1699669,ECO:0000269|PubMed:1710600;Dbxref=PMID:1699669,PMID:1710600
CFTR	P13569	464	528	508	508	Natural variant	ID=VAR_000172;Note=F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=dbSNP:rs74571530,PMID:1379210
CFTR	P13569	464	528	508	508	Natural variant	ID=VAR_000171;Note=In CF and CBAVD%3B most common mutation in Caucasian CF chromosomes%3B impairs protein folding and stability%3B causes local changes to the surface that mediates interactions between domains%3B decreases frequency of channel opening in vitro%3B impairs maturation and trafficking to the cell membrane%3B impairs recycling to the cell membrane after endocytosis. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12394343,ECO:0000269|PubMed:12529365,ECO:0000269|PubMed:1284548,ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:15528182,ECO:0000269|PubMed:15716351,ECO:0000269|PubMed:1699669,ECO:0000269|PubMed:17098864,ECO:0000269|PubMed:1710600,ECO:0000269|PubMed:17329263,ECO:0000269|PubMed:20008117,ECO:0000269|PubMed:20150177,ECO:0000269|PubMed:20691141,ECO:0000269|PubMed:25330774,ECO:0000269|PubMed:28001373,ECO:0000269|PubMed:28087700;Dbxref=PMID:12394343,PMID:12529365,PMID:1284548,PMID:1379210,PMID:15528182,PMID:15716351,PMID:1699669,PMID:17098864,PMID:1710600,PMID:17329263,PMID:20008117,PMID:20150177,PMID:20691141,PMID:25330774,PMID:28001373,PMID:28087700
CFTR	P13569	464	528	513	513	Natural variant	ID=VAR_000173;Note=In CBAVD. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10651488;Dbxref=dbSNP:rs397508225,PMID:10651488
CFTR	P13569	464	528	520	520	Natural variant	ID=VAR_000174;Note=In CF. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1284466;Dbxref=dbSNP:rs77646904,PMID:1284466
CFTR	P13569	560	588	542	1480	Natural variant	ID=VAR_080305;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	830	873	542	1480	Natural variant	ID=VAR_080305;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1046	1122	542	1480	Natural variant	ID=VAR_080305;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	542	1480	Natural variant	ID=VAR_080305;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1291	1321	542	1480	Natural variant	ID=VAR_080305;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	560	588	560	560	Natural variant	ID=VAR_000184;Note=In CF. R->K;Dbxref=dbSNP:rs80055610
CFTR	P13569	560	588	560	560	Natural variant	ID=VAR_000185;Note=In CF. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9482579;Dbxref=dbSNP:rs397508267,PMID:9482579
CFTR	P13569	560	588	560	560	Natural variant	ID=VAR_000186;Note=In CF%3B impairs maturation and trafficking to the cell membrane%3B decrease in channel activity. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17098864;Dbxref=dbSNP:rs80055610,PMID:17098864
CFTR	P13569	560	588	561	561	Natural variant	ID=VAR_080307;Note=In CF%3B impairs maturation and trafficking to the cell membrane%3B decrease in channel activity. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17098864;Dbxref=dbSNP:rs121909047,PMID:17098864
CFTR	P13569	560	588	562	562	Natural variant	ID=VAR_000187;Note=In CBAVD and CF%3B unknown pathological significance%3B found in cis of the IVS8 TG11-T5 allele%2C which affects exon 9 splicing%3B no effect on protein maturation%2C trafficking to the cell membrane%2C nor on channel activity. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:17098864,ECO:0000269|PubMed:17329263,ECO:0000269|PubMed:20691141;Dbxref=dbSNP:rs1800097,PMID:1379210,PMID:17098864,PMID:17329263,PMID:20691141
CFTR	P13569	560	588	562	562	Natural variant	ID=VAR_000188;Note=In CF. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8956039;Dbxref=dbSNP:rs1800097,PMID:8956039
CFTR	P13569	560	588	563	563	Natural variant	ID=VAR_000189;Note=In CF. Y->N;Dbxref=dbSNP:rs121909006
CFTR	P13569	560	588	569	569	Natural variant	ID=VAR_000190;Note=In CF. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8723693;Dbxref=dbSNP:rs397508277,PMID:8723693
CFTR	P13569	560	588	569	569	Natural variant	ID=VAR_000191;Note=In CF. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9482579;Dbxref=dbSNP:rs397508276,PMID:9482579
CFTR	P13569	560	588	569	569	Natural variant	ID=VAR_000192;Note=In CF. Y->H;Dbxref=dbSNP:rs397508276
CFTR	P13569	560	588	571	571	Natural variant	ID=VAR_000193;Note=In CF. L->S;Dbxref=dbSNP:rs397508280
CFTR	P13569	560	588	572	572	Natural variant	ID=VAR_000194;Note=In CF%3B impaired maturation of glycan chains. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1712898,ECO:0000269|PubMed:7541273;Dbxref=dbSNP:rs397508282,PMID:1712898,PMID:7541273
CFTR	P13569	560	588	574	574	Natural variant	ID=VAR_000195;Note=In CF. P->H;Dbxref=dbSNP:rs121908758
CFTR	P13569	560	588	576	576	Natural variant	ID=VAR_000196;Note=In CBAVD%3B unknown pathological significance. G->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:17329263;Dbxref=dbSNP:rs1800098,PMID:1379210,PMID:17329263
CFTR	P13569	560	588	579	579	Natural variant	ID=VAR_000197;Note=In CF. D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094564,ECO:0000269|PubMed:7544319;Dbxref=dbSNP:rs397508288,PMID:10094564,PMID:7544319
CFTR	P13569	830	873	710	1480	Natural variant	ID=VAR_080308;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1046	1122	710	1480	Natural variant	ID=VAR_080308;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	710	1480	Natural variant	ID=VAR_080308;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1291	1321	710	1480	Natural variant	ID=VAR_080308;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	830	873	846	1480	Natural variant	ID=VAR_080309;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1046	1122	846	1480	Natural variant	ID=VAR_080309;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	846	1480	Natural variant	ID=VAR_080309;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1291	1321	846	1480	Natural variant	ID=VAR_080309;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	830	873	866	866	Natural variant	ID=VAR_000221;Note=In CF. C->Y;Dbxref=dbSNP:rs193922506
CFTR	P13569	1046	1122	890	1480	Natural variant	ID=VAR_080310;Note=In CF. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12394343,ECO:0000269|PubMed:7522211;Dbxref=PMID:12394343,PMID:7522211
CFTR	P13569	1156	1239	890	1480	Natural variant	ID=VAR_080310;Note=In CF. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12394343,ECO:0000269|PubMed:7522211;Dbxref=PMID:12394343,PMID:7522211
CFTR	P13569	1291	1321	890	1480	Natural variant	ID=VAR_080310;Note=In CF. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12394343,ECO:0000269|PubMed:7522211;Dbxref=PMID:12394343,PMID:7522211
CFTR	P13569	1046	1122	1052	1052	Natural variant	ID=VAR_000232;Note=In CF. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7683628;Dbxref=dbSNP:rs150212784,PMID:7683628
CFTR	P13569	1046	1122	1061	1061	Natural variant	ID=VAR_000233;Note=In CF. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7683628,ECO:0000269|PubMed:8723695;Dbxref=dbSNP:rs142394380,PMID:7683628,PMID:8723695
CFTR	P13569	1046	1122	1063	1480	Natural variant	ID=VAR_080317;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	1063	1480	Natural variant	ID=VAR_080317;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1291	1321	1063	1480	Natural variant	ID=VAR_080317;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1046	1122	1065	1065	Natural variant	ID=VAR_000234;Note=In CF. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7522211;Dbxref=dbSNP:rs121909036,PMID:7522211
CFTR	P13569	1046	1122	1065	1065	Natural variant	ID=VAR_000235;Note=In CF. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452054;Dbxref=dbSNP:rs121909036,PMID:9452054
CFTR	P13569	1046	1122	1066	1066	Natural variant	ID=VAR_000236;Note=In CF. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:9375855;Dbxref=dbSNP:rs78194216,PMID:1379210,PMID:9375855
CFTR	P13569	1046	1122	1066	1066	Natural variant	ID=VAR_000237;Note=In CF. R->H;Dbxref=dbSNP:rs121909019
CFTR	P13569	1046	1122	1066	1066	Natural variant	ID=VAR_000238;Note=In CF. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7683628;Dbxref=dbSNP:rs121909019,PMID:7683628
CFTR	P13569	1046	1122	1067	1067	Natural variant	ID=VAR_000239;Note=In CF%3B loss of bicarbonate transport%3B no effect on protein maturation%2C subcellular location at the plasma membrane%2C nor on chloride channel activity. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11242048;Dbxref=dbSNP:rs121909020,PMID:11242048
CFTR	P13569	1046	1122	1067	1067	Natural variant	ID=VAR_000240;Note=A->V;Dbxref=dbSNP:rs1800114
CFTR	P13569	1046	1122	1069	1069	Natural variant	ID=VAR_080318;Note=In CBAVD%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17329263;Dbxref=dbSNP:rs200321110,PMID:17329263
CFTR	P13569	1046	1122	1070	1070	Natural variant	ID=VAR_000242;Note=In CF. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9401006;Dbxref=dbSNP:rs78769542,PMID:9401006
CFTR	P13569	1046	1122	1070	1070	Natural variant	ID=VAR_000241;Note=In CF%3B decrease in bicarbonate transport%3B no effect on chloride channel activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11242048,ECO:0000269|PubMed:7683628;Dbxref=dbSNP:rs78769542,PMID:11242048,PMID:7683628
CFTR	P13569	1046	1122	1070	1070	Natural variant	ID=VAR_011564;Note=In CBAVD. R->W;Dbxref=dbSNP:rs202179988
CFTR	P13569	1046	1122	1071	1071	Natural variant	ID=VAR_000243;Note=In CF. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7522211;Dbxref=dbSNP:rs121909037,PMID:7522211
CFTR	P13569	1046	1122	1072	1072	Natural variant	ID=VAR_000244;Note=In CF. P->L
CFTR	P13569	1046	1122	1077	1077	Natural variant	ID=VAR_000245;Note=In CF. L->P;Dbxref=dbSNP:rs139304906
CFTR	P13569	1046	1122	1085	1085	Natural variant	ID=VAR_000246;Note=In CF. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7683628;Dbxref=dbSNP:rs79635528,PMID:7683628
CFTR	P13569	1046	1122	1092	1480	Natural variant	ID=VAR_080319;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	1092	1480	Natural variant	ID=VAR_080319;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1291	1321	1092	1480	Natural variant	ID=VAR_080319;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1046	1122	1098	1098	Natural variant	ID=VAR_000247;Note=In CF. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7537150;Dbxref=dbSNP:rs397508531,PMID:7537150
CFTR	P13569	1046	1122	1101	1101	Natural variant	ID=VAR_000248;Note=In CF. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7680525;Dbxref=dbSNP:rs36210737,PMID:7680525
CFTR	P13569	1046	1122	1101	1101	Natural variant	ID=VAR_011565;Note=In CF. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7683628;Dbxref=dbSNP:rs36210737,PMID:7683628
CFTR	P13569	1156	1239	1162	1480	Natural variant	ID=VAR_080321;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1291	1321	1162	1480	Natural variant	ID=VAR_080321;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	1162	1162	Natural variant	ID=VAR_000252;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=dbSNP:rs1800120,PMID:1379210
CFTR	P13569	1156	1239	1200	1200	Natural variant	ID=VAR_080322;Note=In CF%3B unknown pathological significance. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1379210;Dbxref=PMID:1379210
CFTR	P13569	1156	1239	1204	1480	Natural variant	ID=VAR_080323;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7522211;Dbxref=PMID:7522211
CFTR	P13569	1291	1321	1204	1480	Natural variant	ID=VAR_080323;Note=In CF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7522211;Dbxref=PMID:7522211
CFTR	P13569	1156	1239	1220	1220	Natural variant	ID=VAR_000253;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7522211;Dbxref=dbSNP:rs1800123,PMID:7522211
CFTR	P13569	1156	1239	1234	1234	Natural variant	ID=VAR_000254;Note=In CF. I->V;Dbxref=dbSNP:rs75389940
CFTR	P13569	1156	1239	1235	1235	Natural variant	ID=VAR_000255;Note=In CF. S->R;Dbxref=dbSNP:rs34911792
CFTR	P13569	1291	1321	1282	1480	Natural variant	ID=VAR_080324;Note=In CF and CBAVD. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:17329263;Dbxref=PMID:1379210,PMID:17329263
CFTR	P13569	1291	1321	1291	1291	Natural variant	ID=VAR_000264;Note=In CF. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1284466;Dbxref=dbSNP:rs121909015,PMID:1284466
CFTR	P13569	1291	1321	1291	1291	Natural variant	ID=VAR_000265;Note=In CF. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7525450;Dbxref=dbSNP:rs397508621,PMID:7525450
CFTR	P13569	1291	1321	1303	1303	Natural variant	ID=VAR_000266;Note=In CF. N->H;Dbxref=dbSNP:rs121909042
CFTR	P13569	1291	1321	1303	1303	Natural variant	ID=VAR_000267;Note=In CF%3B impaired maturation of glycan chains%3B has low in vitro channel activity at low temperature. N->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12394343,ECO:0000269|PubMed:1379210,ECO:0000269|PubMed:1712898,ECO:0000269|PubMed:17182731,ECO:0000269|PubMed:9401006;Dbxref=dbSNP:rs80034486,PMID:12394343,PMID:1379210,PMID:1712898,PMID:17182731,PMID:9401006
CFTR	P13569	403	464	464	464	Mutagenesis	Note=Impaired maturation of glycan chains indicating impaired trafficking from the endoplasmic reticulum to the cell membrane. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1699669;Dbxref=PMID:1699669
CFTR	P13569	464	528	464	464	Mutagenesis	Note=Impaired maturation of glycan chains indicating impaired trafficking from the endoplasmic reticulum to the cell membrane. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1699669;Dbxref=PMID:1699669
CFTR	P13569	464	528	508	508	Mutagenesis	Note=Impaired maturation of glycan chains indicating impaired trafficking from the endoplasmic reticulum to the cell membrane. F->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1699669,ECO:0000269|PubMed:1712898;Dbxref=PMID:1699669,PMID:1712898
CFTR	P13569	830	873	833	833	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CFTR	P13569	403	464	403	411	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBS
CFTR	P13569	403	464	414	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BBT
CFTR	P13569	403	464	433	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XMI
CFTR	P13569	403	464	440	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	403	464	453	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	403	464	464	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	464	528	464	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	464	528	478	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	464	528	488	491	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	464	528	499	501	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZG
CFTR	P13569	464	528	502	507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	464	528	514	523	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	464	528	527	530	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	560	588	550	563	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	560	588	567	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	560	588	574	577	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	560	588	580	589	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZE
CFTR	P13569	1156	1239	1204	1207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	1156	1239	1210	1223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	1156	1239	1226	1234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	1156	1239	1239	1245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	1291	1321	1297	1299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	1291	1321	1300	1304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
CFTR	P13569	1291	1321	1312	1321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3GD7
DDX54	Q8TDD1	573	646	1	881	Chain	ID=PRO_0000055056;Note=ATP-dependent RNA helicase DDX54
DDX54	Q8TDD1	471	548	1	881	Chain	ID=PRO_0000055056;Note=ATP-dependent RNA helicase DDX54
DDX54	Q8TDD1	426	471	1	881	Chain	ID=PRO_0000055056;Note=ATP-dependent RNA helicase DDX54
DDX54	Q8TDD1	312	356	1	881	Chain	ID=PRO_0000055056;Note=ATP-dependent RNA helicase DDX54
DDX54	Q8TDD1	471	548	326	473	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX54	Q8TDD1	426	471	326	473	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX54	Q8TDD1	312	356	326	473	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX54	Q8TDD1	573	646	605	647	Region	Note=Interaction with nuclear receptors
DDX54	Q8TDD1	573	646	644	644	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CHD4	Q14839	1629	1653	1	1912	Chain	ID=PRO_0000080228;Note=Chromodomain-helicase-DNA-binding protein 4
CHD4	Q14839	1629	1653	1577	1912	Region	Note=Required for interaction with PCNT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17626165;Dbxref=PMID:17626165
CHD4	Q14839	1629	1653	1643	1643	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CHD4	Q14839	1629	1653	1653	1653	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
CHD4	Q14839	1629	1653	1636	1636	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CHD4	Q14839	1629	1653	1643	1643	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
CHD4	Q14839	1629	1653	1647	1647	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
CHD4	Q14839	1629	1653	1648	1648	Natural variant	ID=VAR_031675;Note=S->L;Dbxref=dbSNP:rs35512811
CHN1	P15882	321	367	2	459	Chain	ID=PRO_0000056694;Note=N-chimaerin
CHN1	P15882	237	295	2	459	Chain	ID=PRO_0000056694;Note=N-chimaerin
CHN1	P15882	183	209	2	459	Chain	ID=PRO_0000056694;Note=N-chimaerin
CHN1	P15882	321	367	268	459	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
CHN1	P15882	237	295	268	459	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
CHN1	P15882	237	295	205	255	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
CHN1	P15882	183	209	205	255	Zinc finger	Note=Phorbol-ester/DAG-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226
CHN1	P15882	183	209	192	192	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHN1	P15882	321	367	340	340	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30337
CHN1	P15882	183	209	1	183	Alternative sequence	ID=VSP_001636;Note=In isoform Alpha-1. MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKR->MPSKESWSGRKTNRAAVHKSKQEGRQQDLLIAALGMKLGSPKSSVTIWQPLKLFAYSQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:2299665;Dbxref=PMID:14702039,PMID:2299665
CHN1	P15882	183	209	184	209	Alternative sequence	ID=VSP_043297;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHN1	P15882	237	295	252	252	Natural variant	ID=VAR_047945;Note=In DURS2%3B behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro%3B appears to enhance membrane translocation and CHN1 activity by destabilizing the closed conformation of CHN1 protein in response to phorbol 12-myristate 13-acetate (PMA). P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18653847;Dbxref=dbSNP:rs121912797,PMID:18653847
CHN1	P15882	183	209	208	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CXL
CHN1	P15882	237	295	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CXL
CHN1	P15882	237	295	245	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CXL
CHN1	P15882	237	295	257	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CXL
CHN1	P15882	237	295	270	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	237	295	283	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	321	367	309	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	321	367	323	325	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	321	367	330	332	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	321	367	336	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	321	367	357	359	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
CHN1	P15882	321	367	360	368	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OSA
DDX59	Q5T1V6	489	532	1	619	Chain	ID=PRO_0000282713;Note=Probable ATP-dependent RNA helicase DDX59
DDX59	Q5T1V6	354	438	1	619	Chain	ID=PRO_0000282713;Note=Probable ATP-dependent RNA helicase DDX59
DDX59	Q5T1V6	324	354	1	619	Chain	ID=PRO_0000282713;Note=Probable ATP-dependent RNA helicase DDX59
DDX59	Q5T1V6	354	438	234	405	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX59	Q5T1V6	324	354	234	405	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX59	Q5T1V6	489	532	416	579	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX59	Q5T1V6	354	438	416	579	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX59	Q5T1V6	354	438	353	356	Motif	Note=DEAD box
DDX59	Q5T1V6	324	354	353	356	Motif	Note=DEAD box
DDX59	Q5T1V6	354	438	367	367	Natural variant	ID=VAR_070198;Note=In OFD5%3B markedly reduced expression in fibroblasts compared to wild-type protein%3B impaired SHH signaling in SAG-treated fibroblasts. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23972372;Dbxref=dbSNP:rs587777067,PMID:23972372
DDX60	Q8IY21	1235	1286	1	1712	Chain	ID=PRO_0000318154;Note=Probable ATP-dependent RNA helicase DDX60
DDX60	Q8IY21	858	890	1	1712	Chain	ID=PRO_0000318154;Note=Probable ATP-dependent RNA helicase DDX60
DDX60	Q8IY21	394	446	1	1712	Chain	ID=PRO_0000318154;Note=Probable ATP-dependent RNA helicase DDX60
DDX60	Q8IY21	858	890	772	939	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX60	Q8IY21	1235	1286	1226	1370	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX60	Q8IY21	858	890	889	892	Motif	Note=DEVH box
DDX60	Q8IY21	394	446	415	415	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX60	Q8IY21	394	446	439	439	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CGN	Q9P2M7	857	914	1	1197	Chain	ID=PRO_0000089763;Note=Cingulin
CGN	Q9P2M7	857	914	352	1154	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CGN	Q9P2M7	857	914	772	1197	Alternative sequence	ID=VSP_037040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CMTM3	Q96MX0	49	101	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	101	133	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	49	101	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	101	133	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	49	101	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	101	133	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	49	101	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	101	133	1	182	Chain	ID=PRO_0000186101;Note=CKLF-like MARVEL transmembrane domain-containing protein 3
CMTM3	Q96MX0	49	101	64	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	64	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	64	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	64	84	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	101	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	101	133	131	151	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM3	Q96MX0	49	101	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	101	133	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	49	101	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	101	133	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	49	101	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	101	133	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	49	101	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	101	133	36	155	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM3	Q96MX0	49	101	43	59	Alternative sequence	ID=VSP_008256;Note=In isoform 2. RLLLAESGLSFITFICY->PGGFVCTWCSCPHQPLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	43	59	Alternative sequence	ID=VSP_008256;Note=In isoform 2. RLLLAESGLSFITFICY->PGGFVCTWCSCPHQPLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	43	59	Alternative sequence	ID=VSP_008256;Note=In isoform 2. RLLLAESGLSFITFICY->PGGFVCTWCSCPHQPLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	43	59	Alternative sequence	ID=VSP_008256;Note=In isoform 2. RLLLAESGLSFITFICY->PGGFVCTWCSCPHQPLW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	101	133	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	101	133	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	101	133	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	49	101	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM3	Q96MX0	101	133	60	182	Alternative sequence	ID=VSP_008257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CMTM8	Q8IZV2	49	107	1	173	Chain	ID=PRO_0000186112;Note=CKLF-like MARVEL transmembrane domain-containing protein 8
CMTM8	Q8IZV2	107	146	1	173	Chain	ID=PRO_0000186112;Note=CKLF-like MARVEL transmembrane domain-containing protein 8
CMTM8	Q8IZV2	49	107	40	60	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM8	Q8IZV2	49	107	70	90	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM8	Q8IZV2	49	107	105	125	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM8	Q8IZV2	107	146	105	125	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM8	Q8IZV2	49	107	36	168	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM8	Q8IZV2	107	146	36	168	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM8	Q8IZV2	49	107	50	107	Alternative sequence	ID=VSP_044430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17681841;Dbxref=PMID:17681841
CMTM8	Q8IZV2	107	146	50	107	Alternative sequence	ID=VSP_044430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17681841;Dbxref=PMID:17681841
CMTM8	Q8IZV2	49	107	79	79	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CKLF	Q9UBR5	26	79	1	152	Chain	ID=PRO_0000186094;Note=Chemokine-like factor
CKLF	Q9UBR5	79	111	1	152	Chain	ID=PRO_0000186094;Note=Chemokine-like factor
CKLF	Q9UBR5	26	79	45	65	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CKLF	Q9UBR5	79	111	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CKLF	Q9UBR5	79	111	108	128	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CKLF	Q9UBR5	26	79	13	133	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CKLF	Q9UBR5	79	111	13	133	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CKLF	Q9UBR5	26	79	27	79	Alternative sequence	ID=VSP_050605;Note=In isoform 1 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11415443;Dbxref=PMID:11415443
CKLF	Q9UBR5	79	111	27	79	Alternative sequence	ID=VSP_050605;Note=In isoform 1 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11415443;Dbxref=PMID:11415443
CKLF	Q9UBR5	79	111	80	111	Alternative sequence	ID=VSP_050606;Note=In isoform 4 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11415443;Dbxref=PMID:11415443
CLDN18	P56856	73	128	1	261	Chain	ID=PRO_0000144779;Note=Claudin-18
CLDN18	P56856	168	204	1	261	Chain	ID=PRO_0000144779;Note=Claudin-18
CLDN18	P56856	73	128	28	80	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN18	P56856	73	128	81	101	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN18	P56856	73	128	102	122	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN18	P56856	73	128	123	143	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN18	P56856	168	204	144	174	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN18	P56856	168	204	175	195	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLDN18	P56856	168	204	196	261	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLTC	Q00610	227	265	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	265	323	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	456	507	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	594	649	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	1200	1255	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	1291	1347	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	1441	1478	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	1478	1535	2	1675	Chain	ID=PRO_0000205778;Note=Clathrin heavy chain 1
CLTC	Q00610	594	649	537	683	Repeat	Note=CHCR 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01006,ECO:0000269|PubMed:21816279;Dbxref=PMID:21816279
CLTC	Q00610	1200	1255	1128	1269	Repeat	Note=CHCR 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01006,ECO:0000269|PubMed:21816279;Dbxref=PMID:21816279
CLTC	Q00610	1291	1347	1274	1420	Repeat	Note=CHCR 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01006,ECO:0000269|PubMed:21816279;Dbxref=PMID:21816279
CLTC	Q00610	1441	1478	1423	1566	Repeat	Note=CHCR 7;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01006,ECO:0000269|PubMed:21816279;Dbxref=PMID:21816279
CLTC	Q00610	1478	1535	1423	1566	Repeat	Note=CHCR 7;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01006,ECO:0000269|PubMed:21816279;Dbxref=PMID:21816279
CLTC	Q00610	227	265	2	479	Region	Note=Globular terminal domain
CLTC	Q00610	265	323	2	479	Region	Note=Globular terminal domain
CLTC	Q00610	456	507	2	479	Region	Note=Globular terminal domain
CLTC	Q00610	227	265	196	257	Region	Note=WD40-like repeat 5
CLTC	Q00610	227	265	258	301	Region	Note=WD40-like repeat 6
CLTC	Q00610	265	323	258	301	Region	Note=WD40-like repeat 6
CLTC	Q00610	265	323	302	330	Region	Note=WD40-like repeat 7
CLTC	Q00610	456	507	449	465	Region	Note=Binding site for the uncoating ATPase%2C involved in lattice disassembly;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLTC	Q00610	456	507	457	507	Region	Note=Involved in spindle localization and interaction with TACC3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	480	523	Region	Note=Flexible linker
CLTC	Q00610	594	649	524	1675	Region	Note=Heavy chain arm
CLTC	Q00610	1200	1255	524	1675	Region	Note=Heavy chain arm
CLTC	Q00610	1291	1347	524	1675	Region	Note=Heavy chain arm
CLTC	Q00610	1441	1478	524	1675	Region	Note=Heavy chain arm
CLTC	Q00610	1478	1535	524	1675	Region	Note=Heavy chain arm
CLTC	Q00610	594	649	524	634	Region	Note=Distal segment
CLTC	Q00610	594	649	639	1675	Region	Note=Proximal segment
CLTC	Q00610	1200	1255	639	1675	Region	Note=Proximal segment
CLTC	Q00610	1291	1347	639	1675	Region	Note=Proximal segment
CLTC	Q00610	1441	1478	639	1675	Region	Note=Proximal segment
CLTC	Q00610	1478	1535	639	1675	Region	Note=Proximal segment
CLTC	Q00610	1200	1255	1213	1522	Region	Note=Involved in binding clathrin light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTC	Q00610	1291	1347	1213	1522	Region	Note=Involved in binding clathrin light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTC	Q00610	1441	1478	1213	1522	Region	Note=Involved in binding clathrin light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTC	Q00610	1478	1535	1213	1522	Region	Note=Involved in binding clathrin light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTC	Q00610	594	649	634	634	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
CLTC	Q00610	1200	1255	1206	1206	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD5
CLTC	Q00610	1200	1255	1229	1229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CLTC	Q00610	1441	1478	1441	1441	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CLTC	Q00610	1441	1478	1441	1441	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD5
CLTC	Q00610	1441	1478	1477	1477	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
CLTC	Q00610	1478	1535	1487	1487	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD5
CLTC	Q00610	1478	1535	1494	1494	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:19369195,PMID:23186163,PMID:24275569
CLTC	Q00610	1478	1535	1501	1501	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CLTC	Q00610	1200	1255	1199	1675	Natural variant	ID=VAR_080725;Note=In MRD56. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100083;Dbxref=PMID:29100083
CLTC	Q00610	1291	1347	1199	1675	Natural variant	ID=VAR_080725;Note=In MRD56. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100083;Dbxref=PMID:29100083
CLTC	Q00610	1441	1478	1199	1675	Natural variant	ID=VAR_080725;Note=In MRD56. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100083;Dbxref=PMID:29100083
CLTC	Q00610	1478	1535	1199	1675	Natural variant	ID=VAR_080725;Note=In MRD56. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100083;Dbxref=PMID:29100083
CLTC	Q00610	1200	1255	1207	1207	Natural variant	ID=VAR_080726;Note=In MRD56%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29100083;Dbxref=PMID:29100083
CLTC	Q00610	456	507	480	484	Mutagenesis	Note=Disrupts spindle localization and interaction with TACC3. LRANV->ERGQC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	481	481	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-487%2C E-500%2C E-506 and E-507. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	487	487	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-481%2C E-500%2C E-506 and E-507. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	500	500	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-444%2C E-445%2C E-506 and E-507. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	500	500	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-481%2C E-487%2C E-506 and E-507. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	506	506	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-444%2C E-445%2C E-500 and E-507. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	506	506	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-481%2C E-487%2C E-500 and E-507. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	507	507	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-444%2C E-445%2C E-500 and E-506. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	456	507	507	507	Mutagenesis	Note=Disrupts spindle localization%3B when associated with E-481%2C E-487%2C E-500 and E-506. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918938;Dbxref=PMID:23918938
CLTC	Q00610	227	265	225	232	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	227	265	246	250	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	227	265	261	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	261	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	268	271	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	272	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	280	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	292	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	303	309	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	310	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTC	Q00610	265	323	323	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4G55
CLTCL1	P53675	1535	1609	2	1640	Chain	ID=PRO_0000205786;Note=Clathrin heavy chain 2
CLTCL1	P53675	1478	1535	2	1640	Chain	ID=PRO_0000205786;Note=Clathrin heavy chain 2
CLTCL1	P53675	1291	1347	2	1640	Chain	ID=PRO_0000205786;Note=Clathrin heavy chain 2
CLTCL1	P53675	265	323	2	1640	Chain	ID=PRO_0000205786;Note=Clathrin heavy chain 2
CLTCL1	P53675	227	265	2	1640	Chain	ID=PRO_0000205786;Note=Clathrin heavy chain 2
CLTCL1	P53675	1291	1347	1274	1420	Repeat	Note=CHCR 6
CLTCL1	P53675	1535	1609	1423	1566	Repeat	Note=CHCR 7
CLTCL1	P53675	1478	1535	1423	1566	Repeat	Note=CHCR 7
CLTCL1	P53675	265	323	2	479	Region	Note=Globular terminal domain
CLTCL1	P53675	227	265	2	479	Region	Note=Globular terminal domain
CLTCL1	P53675	227	265	196	257	Region	Note=WD40-like repeat 5
CLTCL1	P53675	265	323	258	301	Region	Note=WD40-like repeat 6
CLTCL1	P53675	227	265	258	301	Region	Note=WD40-like repeat 6
CLTCL1	P53675	265	323	302	330	Region	Note=WD40-like repeat 7
CLTCL1	P53675	1535	1609	524	1640	Region	Note=Heavy chain arm
CLTCL1	P53675	1478	1535	524	1640	Region	Note=Heavy chain arm
CLTCL1	P53675	1291	1347	524	1640	Region	Note=Heavy chain arm
CLTCL1	P53675	1535	1609	639	1640	Region	Note=Proximal segment
CLTCL1	P53675	1478	1535	639	1640	Region	Note=Proximal segment
CLTCL1	P53675	1291	1347	639	1640	Region	Note=Proximal segment
CLTCL1	P53675	1478	1535	1213	1522	Region	Note=Involved in binding clathrin light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTCL1	P53675	1291	1347	1213	1522	Region	Note=Involved in binding clathrin light chain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTCL1	P53675	1535	1609	1551	1640	Region	Note=Trimerization;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLTCL1	P53675	1478	1535	1487	1487	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FD5
CLTCL1	P53675	1478	1535	1494	1494	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00610
CLTCL1	P53675	1478	1535	1501	1501	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00610
CLTCL1	P53675	1535	1609	1479	1535	Alternative sequence	ID=VSP_001100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8733129,ECO:0000303|PubMed:8844170;Dbxref=PMID:14702039,PMID:8733129,PMID:8844170
CLTCL1	P53675	1478	1535	1479	1535	Alternative sequence	ID=VSP_001100;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8733129,ECO:0000303|PubMed:8844170;Dbxref=PMID:14702039,PMID:8733129,PMID:8844170
CLTCL1	P53675	265	323	279	279	Natural variant	ID=VAR_055655;Note=Y->C;Dbxref=dbSNP:rs807459
CLTCL1	P53675	1291	1347	1316	1316	Natural variant	ID=VAR_059215;Note=M->V;Dbxref=dbSNP:rs1061325
CLTCL1	P53675	1535	1609	1592	1592	Natural variant	ID=VAR_059217;Note=V->M;Dbxref=dbSNP:rs2073738
CLTCL1	P53675	265	323	320	320	Sequence conflict	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD3E	P07766	34	117	23	207	Chain	ID=PRO_0000014607;Note=T-cell surface glycoprotein CD3 epsilon chain
CD3E	P07766	117	173	23	207	Chain	ID=PRO_0000014607;Note=T-cell surface glycoprotein CD3 epsilon chain
CD3E	P07766	34	117	23	126	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3E	P07766	117	173	23	126	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3E	P07766	117	173	127	152	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3E	P07766	117	173	153	207	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD3E	P07766	34	117	32	112	Domain	Note=Ig-like
CD3E	P07766	34	117	49	98	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15136729,ECO:0000269|PubMed:15534202;Dbxref=PMID:15136729,PMID:15534202
CD3E	P07766	34	117	37	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	44	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	57	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	75	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	81	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	89	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	94	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD3E	P07766	34	117	110	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XIW
CD48	P09326	128	217	27	220	Chain	ID=PRO_0000014881;Note=CD48 antigen
CD48	P09326	128	217	132	212	Domain	Note=Ig-like C2-type 2
CD48	P09326	128	217	162	162	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD48	P09326	128	217	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973
CD48	P09326	128	217	154	196	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD48	P09326	128	217	129	169	Alternative sequence	ID=VSP_055598;Note=In isoform 2. DPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDK->GESGEPKSKSPLQWPQMDHCRASWEAWGTLGEEERKTSGQV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CD48	P09326	128	217	170	243	Alternative sequence	ID=VSP_055599;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CD48	P09326	128	217	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDO
CD63	P08962	142	189	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	110	142	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	22	85	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	142	189	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	110	142	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	22	85	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	142	189	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	110	142	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	22	85	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	142	189	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	110	142	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	22	85	2	238	Chain	ID=PRO_0000219216;Note=CD63 antigen
CD63	P08962	22	85	12	32	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	12	32	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	12	32	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	12	32	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	33	51	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	33	51	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	33	51	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	33	51	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	52	72	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	73	81	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	73	81	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	73	81	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	73	81	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	82	102	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	110	142	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	110	142	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	110	142	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	110	142	103	203	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	110	142	130	130	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:19159218
CD63	P08962	110	142	130	130	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:19159218
CD63	P08962	110	142	130	130	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:19159218
CD63	P08962	110	142	130	130	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:19159218
CD63	P08962	142	189	150	150	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	150	150	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	150	150	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	150	150	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	142	189	172	172	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD63	P08962	22	85	1	82	Alternative sequence	ID=VSP_046996;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	1	82	Alternative sequence	ID=VSP_046996;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	1	82	Alternative sequence	ID=VSP_046996;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	1	82	Alternative sequence	ID=VSP_046996;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	23	45	Alternative sequence	ID=VSP_045300;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
CD63	P08962	22	85	23	45	Alternative sequence	ID=VSP_045300;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
CD63	P08962	22	85	23	45	Alternative sequence	ID=VSP_045300;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
CD63	P08962	22	85	23	45	Alternative sequence	ID=VSP_045300;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
CD63	P08962	22	85	36	36	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	36	36	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	36	36	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD63	P08962	22	85	36	36	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC45	O75419	37	68	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	68	114	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	218	234	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	319	351	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	352	405	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	452	480	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	37	68	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	68	114	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	218	234	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	319	351	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	352	405	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	452	480	1	566	Chain	ID=PRO_0000192815;Note=Cell division control protein 45 homolog
CDC45	O75419	37	68	68	113	Alternative sequence	ID=VSP_043129;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC45	O75419	68	114	68	113	Alternative sequence	ID=VSP_043129;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC45	O75419	37	68	68	113	Alternative sequence	ID=VSP_043129;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC45	O75419	68	114	68	113	Alternative sequence	ID=VSP_043129;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC45	O75419	68	114	81	81	Natural variant	ID=VAR_019286;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs13447203
CDC45	O75419	68	114	81	81	Natural variant	ID=VAR_019286;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs13447203
CDC45	O75419	352	405	356	356	Natural variant	ID=VAR_053026;Note=M->R;Dbxref=dbSNP:rs17209274
CDC45	O75419	352	405	356	356	Natural variant	ID=VAR_053026;Note=M->R;Dbxref=dbSNP:rs17209274
CDC45	O75419	352	405	376	376	Natural variant	ID=VAR_019287;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs13447263
CDC45	O75419	352	405	376	376	Natural variant	ID=VAR_019287;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs13447263
CDC45	O75419	68	114	100	100	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC45	O75419	68	114	100	100	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC45	O75419	319	351	346	346	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC45	O75419	319	351	346	346	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC45	O75419	37	68	27	42	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	27	42	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	46	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	46	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	55	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	55	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	37	68	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	66	68	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	70	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	70	78	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	83	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	83	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	106	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	106	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	113	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	68	114	113	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	218	234	214	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	218	234	214	229	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	319	351	322	326	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	319	351	322	326	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	319	351	329	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	319	351	329	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	319	351	334	350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	319	351	334	350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	356	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	356	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	369	372	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	369	372	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	373	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	373	384	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	389	391	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	389	391	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	393	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	352	405	393	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	452	480	457	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	452	480	457	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	452	480	463	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDC45	O75419	452	480	463	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DGO
CDK17	Q00537	270	291	1	523	Chain	ID=PRO_0000086487;Note=Cyclin-dependent kinase 17
CDK17	Q00537	139	181	1	523	Chain	ID=PRO_0000086487;Note=Cyclin-dependent kinase 17
CDK17	Q00537	39	94	1	523	Chain	ID=PRO_0000086487;Note=Cyclin-dependent kinase 17
CDK17	Q00537	270	291	192	473	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK17	Q00537	39	94	80	80	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
CDK17	Q00537	39	94	92	92	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CDK17	Q00537	139	181	146	146	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
CDK17	Q00537	139	181	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:23186163
CDK17	Q00537	139	181	180	180	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
CDIPT	O14735	14	59	1	213	Chain	ID=PRO_0000056802;Note=CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDIPT	O14735	14	59	1	213	Chain	ID=PRO_0000056802;Note=CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDIPT	O14735	14	59	6	26	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDIPT	O14735	14	59	6	26	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDIPT	O14735	14	59	29	49	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDIPT	O14735	14	59	29	49	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDIPT	O14735	14	59	1	14	Alternative sequence	ID=VSP_013618;Note=In isoform 2. MPDENIFLFVPNLI->MLPTAAGFSIWGQVGAAREAPRCQTKISSCSCPTSSVSAAHGPGPNERARGLGGLPDPALSPRVPFQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDIPT	O14735	14	59	1	14	Alternative sequence	ID=VSP_013618;Note=In isoform 2. MPDENIFLFVPNLI->MLPTAAGFSIWGQVGAAREAPRCQTKISSCSCPTSSVSAAHGPGPNERARGLGGLPDPALSPRVPFQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDIPT	O14735	14	59	15	59	Alternative sequence	ID=VSP_054767;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDIPT	O14735	14	59	15	59	Alternative sequence	ID=VSP_054767;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDHR2	Q9BYE9	17	41	1	20	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	1	20	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	1	20	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	21	1310	Chain	ID=PRO_0000004011;Note=Cadherin-related family member 2
CDHR2	Q9BYE9	606	686	21	1310	Chain	ID=PRO_0000004011;Note=Cadherin-related family member 2
CDHR2	Q9BYE9	17	41	21	1310	Chain	ID=PRO_0000004011;Note=Cadherin-related family member 2
CDHR2	Q9BYE9	606	686	21	1310	Chain	ID=PRO_0000004011;Note=Cadherin-related family member 2
CDHR2	Q9BYE9	17	41	21	1310	Chain	ID=PRO_0000004011;Note=Cadherin-related family member 2
CDHR2	Q9BYE9	606	686	21	1310	Chain	ID=PRO_0000004011;Note=Cadherin-related family member 2
CDHR2	Q9BYE9	17	41	21	1154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	21	1154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	21	1154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	21	1154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	21	1154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	21	1154	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	27	124	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDHR2	Q9BYE9	17	41	27	124	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDHR2	Q9BYE9	17	41	27	124	Domain	Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDHR2	Q9BYE9	606	686	586	695	Domain	Note=Cadherin 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDHR2	Q9BYE9	606	686	586	695	Domain	Note=Cadherin 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDHR2	Q9BYE9	606	686	586	695	Domain	Note=Cadherin 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDHR2	Q9BYE9	17	41	29	29	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	29	29	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	29	29	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	616	616	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	616	616	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	616	616	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	632	632	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	632	632	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	632	632	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	680	680	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	680	680	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	606	686	680	680	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDHR2	Q9BYE9	17	41	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CZR
CDHR2	Q9BYE9	17	41	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CZR
CDHR2	Q9BYE9	17	41	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CZR
CDHR2	Q9BYE9	17	41	32	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CZR
CDHR2	Q9BYE9	17	41	32	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CZR
CDHR2	Q9BYE9	17	41	32	36	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5CZR
CDK12	Q9NYV4	644	702	1	1490	Chain	ID=PRO_0000085715;Note=Cyclin-dependent kinase 12
CDK12	Q9NYV4	749	806	1	1490	Chain	ID=PRO_0000085715;Note=Cyclin-dependent kinase 12
CDK12	Q9NYV4	870	888	1	1490	Chain	ID=PRO_0000085715;Note=Cyclin-dependent kinase 12
CDK12	Q9NYV4	923	948	1	1490	Chain	ID=PRO_0000085715;Note=Cyclin-dependent kinase 12
CDK12	Q9NYV4	988	1031	1	1490	Chain	ID=PRO_0000085715;Note=Cyclin-dependent kinase 12
CDK12	Q9NYV4	749	806	727	1020	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK12	Q9NYV4	870	888	727	1020	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK12	Q9NYV4	923	948	727	1020	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK12	Q9NYV4	988	1031	727	1020	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK12	Q9NYV4	749	806	756	756	Binding site	Note=ATP
CDK12	Q9NYV4	644	702	644	644	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3MJK5
CDK12	Q9NYV4	644	702	681	681	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
CDK12	Q9NYV4	644	702	685	685	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
CDK12	Q9NYV4	644	702	692	692	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:23186163
CDK12	Q9NYV4	644	702	655	655	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CDK12	Q9NYV4	870	888	877	877	Mutagenesis	Note=Abolishes kinase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24662513;Dbxref=PMID:24662513
CDK12	Q9NYV4	749	806	747	749	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	749	806	752	758	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	749	806	761	763	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ACB
CDK12	Q9NYV4	749	806	764	767	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UN0
CDK12	Q9NYV4	749	806	769	778	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	749	806	789	794	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	749	806	802	804	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5ACB
CDK12	Q9NYV4	870	888	873	875	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	870	888	886	888	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	923	948	916	931	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	923	948	941	952	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	988	1031	986	988	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	988	1031	991	1000	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	988	1031	1005	1007	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	988	1031	1011	1014	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	988	1031	1018	1021	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDK12	Q9NYV4	988	1031	1025	1027	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NST
CDKAL1	Q5VV42	412	433	1	579	Chain	ID=PRO_0000298670;Note=Threonylcarbamoyladenosine tRNA methylthiotransferase
CDKAL1	Q5VV42	412	433	1	579	Chain	ID=PRO_0000298670;Note=Threonylcarbamoyladenosine tRNA methylthiotransferase
CDKAL1	Q5VV42	412	433	431	493	Domain	Note=TRAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00208
CDKAL1	Q5VV42	412	433	431	493	Domain	Note=TRAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00208
CDKAL1	Q5VV42	412	433	98	579	Alternative sequence	ID=VSP_027452;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDKAL1	Q5VV42	412	433	98	579	Alternative sequence	ID=VSP_027452;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDKAL1	Q5VV42	412	433	413	433	Alternative sequence	ID=VSP_027453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDKAL1	Q5VV42	412	433	413	433	Alternative sequence	ID=VSP_027453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDKL1	Q00532	266	323	1	358	Chain	ID=PRO_0000085810;Note=Cyclin-dependent kinase-like 1
CDKL1	Q00532	247	266	1	358	Chain	ID=PRO_0000085810;Note=Cyclin-dependent kinase-like 1
CDKL1	Q00532	266	323	5	288	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDKL1	Q00532	247	266	5	288	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDKL1	Q00532	266	323	248	358	Alternative sequence	ID=VSP_041242;Note=In isoform 2. EPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI->SLCLSVTLTEGGLLASGAVKRSQMGSSVSQATSWPHPDIVAETAELDDIAMARQTPVMLRFNRQKEQEKYLSYGA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CDKL1	Q00532	247	266	248	358	Alternative sequence	ID=VSP_041242;Note=In isoform 2. EPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI->SLCLSVTLTEGGLLASGAVKRSQMGSSVSQATSWPHPDIVAETAELDDIAMARQTPVMLRFNRQKEQEKYLSYGA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CDKL1	Q00532	266	323	268	276	Alternative sequence	ID=VSP_059391;Note=In isoform 3. CLHMDPTQR->RVPIASRTE
CDKL1	Q00532	266	323	277	358	Alternative sequence	ID=VSP_059392;Note=In isoform 3. Missing
CDKL1	Q00532	266	323	275	275	Natural variant	ID=VAR_020577;Note=Q->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1639063,ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:29420175,ECO:0000269|Ref.3;Dbxref=dbSNP:rs7161563,PMID:1639063,PMID:17344846,PMID:29420175
CDKL1	Q00532	266	323	302	302	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDKL1	Q00532	247	266	250	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AGU
CDKL1	Q00532	266	323	259	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AGU
CDKL1	Q00532	247	266	259	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AGU
CDKL1	Q00532	266	323	273	275	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AGU
CDKL1	Q00532	266	323	279	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AGU
CDKL1	Q00532	266	323	286	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AGU
CDK5	Q00535	104	136	1	292	Chain	ID=PRO_0000085784;Note=Cyclin-dependent-like kinase 5
CDK5	Q00535	104	136	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK5	Q00535	104	136	126	126	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
CDK5	Q00535	104	136	105	136	Alternative sequence	ID=VSP_041948;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19693690;Dbxref=PMID:19693690
CDK5	Q00535	104	136	100	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AU8
CDK5	Q00535	104	136	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AU8
CDK5	Q00535	104	136	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AU8
CHCHD5	Q9BSY4	1	47	1	110	Chain	ID=PRO_0000129167;Note=Coiled-coil-helix-coiled-coil-helix domain-containing protein 5
CHCHD5	Q9BSY4	1	47	9	52	Domain	Note=CHCH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CHCHD5	Q9BSY4	1	47	12	22	Motif	Note=Cx9C motif 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CHCHD5	Q9BSY4	1	47	34	44	Motif	Note=Cx9C motif 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CHCHD5	Q9BSY4	1	47	1	1	Modified residue	Note=N-acetylmethionine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:22814378;Dbxref=PMID:22814378
CHCHD5	Q9BSY4	1	47	12	44	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01150,ECO:0000269|PubMed:22842048;Dbxref=PMID:22842048
CHCHD5	Q9BSY4	1	47	22	34	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01150,ECO:0000269|PubMed:22842048;Dbxref=PMID:22842048
CHCHD5	Q9BSY4	1	47	13	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQL
CHCHD5	Q9BSY4	1	47	29	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQL
CHCHD5	Q9BSY4	1	47	36	46	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQL
CHIC2	Q9UKJ5	110	129	1	165	Chain	ID=PRO_0000189556;Note=Cysteine-rich hydrophobic domain-containing protein 2
CHIC2	Q9UKJ5	58	110	1	165	Chain	ID=PRO_0000189556;Note=Cysteine-rich hydrophobic domain-containing protein 2
CHIC2	Q9UKJ5	58	110	88	106	Motif	Note=CHIC motif (Cys-rich)
CHIC2	Q9UKJ5	110	129	111	112	Site	Note=Breakpoint for translocation to form CHIC2-ETV6 in AML
CHIC2	Q9UKJ5	58	110	88	95	Mutagenesis	Note=Loss of palmitoylation. Abolishes membrane association. CGCLCCCC->SGSLSSSS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11257495;Dbxref=PMID:11257495
CIC	Q96RK0	1442	1486	1	1608	Chain	ID=PRO_0000048598;Note=Protein capicua homolog
CIC	Q96RK0	1442	1486	353	1608	Natural variant	ID=VAR_079294;Note=In MRD45%3B decreased protein expression. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28288114;Dbxref=PMID:28288114
CIC	Q96RK0	1442	1486	992	1608	Natural variant	ID=VAR_079295;Note=In MRD45. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28288114;Dbxref=PMID:28288114
C12orf4	Q9NQ89	344	387	1	552	Chain	ID=PRO_0000089842;Note=Protein C12orf4
C12orf4	Q9NQ89	344	387	1	552	Chain	ID=PRO_0000089842;Note=Protein C12orf4
C12orf4	Q9NQ89	344	387	377	377	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
C12orf4	Q9NQ89	344	387	377	377	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
DENND6B	Q8NEG7	213	234	1	585	Chain	ID=PRO_0000264990;Note=Protein DENND6B
DENND6B	Q8NEG7	124	151	1	585	Chain	ID=PRO_0000264990;Note=Protein DENND6B
DENND6B	Q8NEG7	213	234	43	214	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND6B	Q8NEG7	124	151	43	214	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
CD40LG	P29965	115	136	1	261	Chain	ID=PRO_0000034484;Note=CD40 ligand%2C membrane form
CD40LG	P29965	115	136	113	261	Chain	ID=PRO_0000034485;Note=CD40 ligand%2C soluble form;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8626375;Dbxref=PMID:8626375
CD40LG	P29965	115	136	47	261	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD40LG	P29965	115	136	116	116	Natural variant	ID=VAR_017929;Note=In HIGM1. G->R
CD40LG	P29965	115	136	116	116	Natural variant	ID=VAR_017930;Note=In HIGM1. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26545377,ECO:0000269|PubMed:9746782;Dbxref=PMID:26545377,PMID:9746782
CD40LG	P29965	115	136	123	123	Natural variant	ID=VAR_007514;Note=In HIGM1. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8094231;Dbxref=dbSNP:rs104894778,PMID:8094231
CD40LG	P29965	115	136	125	125	Natural variant	ID=VAR_017926;Note=In HIGM1. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8889581;Dbxref=PMID:8889581
CD40LG	P29965	115	136	126	126	Natural variant	ID=VAR_007515;Note=In HIGM1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7717401;Dbxref=PMID:7717401
CD40LG	P29965	115	136	126	126	Natural variant	ID=VAR_017931;Note=In HIGM1. V->D
CD40LG	P29965	115	136	128	129	Natural variant	ID=VAR_007516;Note=In HIGM1. SE->RG
CD40LG	P29965	115	136	123	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALY
CD40LG	P29965	115	136	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALY
CD27	P26842	89	149	20	260	Chain	ID=PRO_0000034571;Note=CD27 antigen
CD27	P26842	149	179	20	260	Chain	ID=PRO_0000034571;Note=CD27 antigen
CD27	P26842	89	149	20	191	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD27	P26842	149	179	20	191	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD27	P26842	89	149	64	104	Repeat	Note=TNFR-Cys 2
CD27	P26842	89	149	105	141	Repeat	Note=TNFR-Cys 3
CD27	P26842	89	149	95	95	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD27	P26842	89	149	127	127	Glycosylation	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22171320;Dbxref=PMID:22171320
CD27	P26842	89	149	84	96	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
CD27	P26842	89	149	87	104	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
CD27	P26842	89	149	106	117	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
CD27	P26842	89	149	112	120	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00206
CD27	P26842	89	149	88	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TL5
CD27	P26842	89	149	98	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TLJ
CD27	P26842	89	149	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TL5
CD27	P26842	89	149	112	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TL5
CD27	P26842	89	149	117	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TL5
CD302	Q8IX05	98	156	23	232	Chain	ID=PRO_0000252332;Note=CD302 antigen
CD302	Q8IX05	98	156	23	168	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD302	Q8IX05	98	156	32	152	Domain	Note=C-type lectin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
CD302	Q8IX05	98	156	109	109	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD302	Q8IX05	98	156	128	143	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00040
CD302	Q8IX05	98	156	99	156	Alternative sequence	ID=VSP_044258;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CD302	Q8IX05	98	156	139	139	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD302	Q8IX05	98	156	97	100	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NAN
CD302	Q8IX05	98	156	101	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NAN
CD302	Q8IX05	98	156	130	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NAN
CD302	Q8IX05	98	156	133	135	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NAN
CD302	Q8IX05	98	156	151	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NAN
CD9	P21926	91	116	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	116	149	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	149	179	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	179	207	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	91	116	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	116	149	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	149	179	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	179	207	2	228	Chain	ID=PRO_0000219205;Note=CD9 antigen
CD9	P21926	91	116	88	111	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	91	116	88	111	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	91	116	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	116	149	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	149	179	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	179	207	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	91	116	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	116	149	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	149	179	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	179	207	112	195	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	179	207	196	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	179	207	196	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD9	P21926	149	179	152	181	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25551757;Dbxref=PMID:25551757
CD9	P21926	179	207	152	181	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25551757;Dbxref=PMID:25551757
CD9	P21926	149	179	152	181	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25551757;Dbxref=PMID:25551757
CD9	P21926	179	207	152	181	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25551757;Dbxref=PMID:25551757
CD9	P21926	149	179	153	167	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25551757;Dbxref=PMID:25551757
CD9	P21926	149	179	153	167	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25551757;Dbxref=PMID:25551757
CEP95	Q96GE4	49	85	1	821	Chain	ID=PRO_0000234505;Note=Centrosomal protein of 95 kDa
CEP95	Q96GE4	196	238	1	821	Chain	ID=PRO_0000234505;Note=Centrosomal protein of 95 kDa
CEP95	Q96GE4	482	513	1	821	Chain	ID=PRO_0000234505;Note=Centrosomal protein of 95 kDa
CEP95	Q96GE4	690	739	1	821	Chain	ID=PRO_0000234505;Note=Centrosomal protein of 95 kDa
CEP95	Q96GE4	690	739	700	794	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP95	Q96GE4	49	85	1	164	Alternative sequence	ID=VSP_056356;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR66	Q8TBY9	126	249	1	1149	Chain	ID=PRO_0000296255;Note=Cilia- and flagella-associated protein 251
WDR66	Q8TBY9	397	423	1	1149	Chain	ID=PRO_0000296255;Note=Cilia- and flagella-associated protein 251
WDR66	Q8TBY9	423	440	1	1149	Chain	ID=PRO_0000296255;Note=Cilia- and flagella-associated protein 251
WDR66	Q8TBY9	711	769	1	1149	Chain	ID=PRO_0000296255;Note=Cilia- and flagella-associated protein 251
WDR66	Q8TBY9	1078	1112	1	1149	Chain	ID=PRO_0000296255;Note=Cilia- and flagella-associated protein 251
WDR66	Q8TBY9	397	423	385	425	Repeat	Note=WD 2
WDR66	Q8TBY9	423	440	385	425	Repeat	Note=WD 2
WDR66	Q8TBY9	423	440	436	475	Repeat	Note=WD 3
WDR66	Q8TBY9	711	769	688	724	Repeat	Note=WD 8
WDR66	Q8TBY9	711	769	731	774	Repeat	Note=WD 9
WDR66	Q8TBY9	397	423	371	1149	Alternative sequence	ID=VSP_027166;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR66	Q8TBY9	423	440	371	1149	Alternative sequence	ID=VSP_027166;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR66	Q8TBY9	711	769	371	1149	Alternative sequence	ID=VSP_027166;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR66	Q8TBY9	1078	1112	371	1149	Alternative sequence	ID=VSP_027166;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR66	Q8TBY9	1078	1112	942	1149	Alternative sequence	ID=VSP_027168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR66	Q8TBY9	126	249	189	189	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP72	Q9P209	230	301	1	647	Chain	ID=PRO_0000089499;Note=Centrosomal protein of 72 kDa
CEP72	Q9P209	230	301	237	237	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
CEP72	Q9P209	230	301	194	647	Alternative sequence	ID=VSP_037836;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CEP72	Q9P209	230	301	238	238	Natural variant	ID=VAR_050798;Note=P->L;Dbxref=dbSNP:rs869955
CHD9	Q3L8U1	1287	1343	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	1403	1440	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	1904	2206	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	2454	2528	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	2571	2606	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	1287	1343	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	1403	1440	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	1904	2206	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	2439	2513	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	2556	2591	1	2897	Chain	ID=PRO_0000233172;Note=Chromodomain-helicase-DNA-binding protein 9
CHD9	Q3L8U1	1287	1343	1186	1337	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
CHD9	Q3L8U1	1287	1343	1186	1337	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
CHD9	Q3L8U1	2454	2528	2332	2481	Region	Note=Binds A/T-rich DNA
CHD9	Q3L8U1	2439	2513	2332	2481	Region	Note=Binds A/T-rich DNA
CHD9	Q3L8U1	1904	2206	2031	2035	Motif	Note=LXXLL motif 3
CHD9	Q3L8U1	1904	2206	2031	2035	Motif	Note=LXXLL motif 3
CHD9	Q3L8U1	1904	2206	2128	2198	Compositional bias	Note=Ser-rich
CHD9	Q3L8U1	1904	2206	2128	2198	Compositional bias	Note=Ser-rich
CHD9	Q3L8U1	1904	2206	2026	2026	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CHD9	Q3L8U1	1904	2206	2026	2026	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CHD9	Q3L8U1	1904	2206	2058	2058	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
CHD9	Q3L8U1	1904	2206	2058	2058	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
CHD9	Q3L8U1	1904	2206	2059	2059	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
CHD9	Q3L8U1	1904	2206	2059	2059	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
CHD9	Q3L8U1	1904	2206	2075	2075	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHD9	Q3L8U1	1904	2206	2075	2075	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHD9	Q3L8U1	1904	2206	2079	2079	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHD9	Q3L8U1	1904	2206	2079	2079	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHD9	Q3L8U1	1904	2206	2038	2038	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
CHD9	Q3L8U1	1904	2206	2038	2038	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733
CHD9	Q3L8U1	1904	2206	2074	2074	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CHD9	Q3L8U1	1904	2206	2074	2074	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CHD9	Q3L8U1	1904	2206	2206	2206	Alternative sequence	ID=VSP_018085;Note=In isoform 3. R->RA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
CHD9	Q3L8U1	1904	2206	2206	2206	Alternative sequence	ID=VSP_018085;Note=In isoform 3. R->RA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
CHD9	Q3L8U1	1904	2206	2025	2025	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2025	2025	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2069	2069	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2069	2069	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2078	2078	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2078	2078	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2189	2189	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHD9	Q3L8U1	1904	2206	2189	2189	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHMP5	Q9NZZ3	105	129	1	219	Chain	ID=PRO_0000211500;Note=Charged multivesicular body protein 5
CHMP5	Q9NZZ3	105	129	121	158	Region	Note=Interaction with VTA1
CHMP5	Q9NZZ3	105	129	26	179	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CHMP5	Q9NZZ3	105	129	122	122	Sequence conflict	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHPF	Q8IZ52	296	356	1	775	Chain	ID=PRO_0000189560;Note=Chondroitin sulfate synthase 2
CHPF	Q8IZ52	296	356	35	775	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHPF	Q8IZ52	296	356	1	460	Alternative sequence	ID=VSP_053433;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHST9	Q7L1S5	40	53	1	443	Chain	ID=PRO_0000189655;Note=Carbohydrate sulfotransferase 9
CHST9	Q7L1S5	40	53	34	443	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
C9orf72	Q96LT7	246	285	1	481	Chain	ID=PRO_0000089711;Note=Guanine nucleotide exchange C9orf72
C9orf72	Q96LT7	148	168	1	481	Chain	ID=PRO_0000089711;Note=Guanine nucleotide exchange C9orf72
C9orf72	Q96LT7	148	168	23	194	Domain	Note=uDENN C9ORF72-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01179
C9orf72	Q96LT7	246	285	200	343	Domain	Note=cDENN C9ORF72-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01179
C9orf72	Q96LT7	246	285	223	481	Alternative sequence	ID=VSP_014746;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CERS2	Q96G23	204	247	1	380	Chain	ID=PRO_0000185509;Note=Ceramide synthase 2
CERS2	Q96G23	173	204	1	380	Chain	ID=PRO_0000185509;Note=Ceramide synthase 2
CERS2	Q96G23	204	247	1	380	Chain	ID=PRO_0000185509;Note=Ceramide synthase 2
CERS2	Q96G23	173	204	1	380	Chain	ID=PRO_0000185509;Note=Ceramide synthase 2
CERS2	Q96G23	173	204	161	180	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	173	204	161	180	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	173	204	181	201	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	173	204	181	201	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	202	208	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	173	204	202	208	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	202	208	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	173	204	202	208	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	230	263	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	230	263	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS2	Q96G23	204	247	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS2	Q96G23	173	204	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS2	Q96G23	204	247	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS2	Q96G23	173	204	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CHFR	Q96EP1	469	509	1	664	Chain	ID=PRO_0000055872;Note=E3 ubiquitin-protein ligase CHFR
CHFR	Q96EP1	206	262	1	664	Chain	ID=PRO_0000055872;Note=E3 ubiquitin-protein ligase CHFR
CHFR	Q96EP1	134	206	1	664	Chain	ID=PRO_0000055872;Note=E3 ubiquitin-protein ligase CHFR
CHFR	Q96EP1	206	262	244	244	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CHFR	Q96EP1	206	262	115	207	Alternative sequence	ID=VSP_038126;Note=In isoform 5. NVAYLYESLSEKQGMTQESFEANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSCG->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHFR	Q96EP1	134	206	115	207	Alternative sequence	ID=VSP_038126;Note=In isoform 5. NVAYLYESLSEKQGMTQESFEANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSCG->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHFR	Q96EP1	134	206	135	146	Alternative sequence	ID=VSP_009349;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CHFR	Q96EP1	206	262	136	206	Alternative sequence	ID=VSP_009350;Note=In isoform 3. ANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSC->MVPCCVAQAGLKLLGSSDPPTLASQSIVIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHFR	Q96EP1	134	206	136	206	Alternative sequence	ID=VSP_009350;Note=In isoform 3. ANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSC->MVPCCVAQAGLKLLGSSDPPTLASQSIVIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHFR	Q96EP1	469	509	470	470	Alternative sequence	ID=VSP_038127;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHFR	Q96EP1	134	206	166	166	Natural variant	ID=VAR_017582;Note=In a patient with non small cell lung carcinomas%3B homozygous. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612512;Dbxref=dbSNP:rs1176037831,PMID:14612512
CHFR	Q96EP1	134	206	202	202	Natural variant	ID=VAR_017583;Note=In a patient with non small cell lung carcinomas. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612512;Dbxref=PMID:14612512
CHFR	Q96EP1	469	509	497	497	Natural variant	ID=VAR_017585;Note=Common polymorphism. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11948416,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2306541,PMID:11948416,PMID:15489334
CHFR	Q96EP1	134	206	205	205	Mutagenesis	Note=Abolishes phosphorylation but not autoubiquitination%3B when associated with A-39. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14638868;Dbxref=PMID:14638868
CHFR	Q96EP1	206	262	256	256	Sequence conflict	Note=V->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CHFR	Q96EP1	469	509	482	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XOC
CHFR	Q96EP1	469	509	486	488	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XOC
CHFR	Q96EP1	469	509	491	493	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XOC
CHFR	Q96EP1	469	509	496	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XOC
CHMP2A	O43633	56	116	1	222	Chain	ID=PRO_0000211462;Note=Charged multivesicular body protein 2a
CHMP2A	O43633	56	116	1	222	Chain	ID=PRO_0000211462;Note=Charged multivesicular body protein 2a
CHMP2A	O43633	56	116	1	222	Chain	ID=PRO_0000211462;Note=Charged multivesicular body protein 2a
CHMP2A	O43633	56	116	56	222	Region	Note=Interaction with VPS4B
CHMP2A	O43633	56	116	56	222	Region	Note=Interaction with VPS4B
CHMP2A	O43633	56	116	56	222	Region	Note=Interaction with VPS4B
CHEK1	O14757	239	271	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	411	445	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	239	271	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	411	445	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	239	271	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	411	445	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	239	271	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	411	445	1	476	Chain	ID=PRO_0000085848;Note=Serine/threonine-protein kinase Chk1
CHEK1	O14757	239	271	9	265	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CHEK1	O14757	239	271	9	265	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CHEK1	O14757	239	271	9	265	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CHEK1	O14757	239	271	9	265	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CHEK1	O14757	239	271	1	265	Region	Note=Interaction with CLSPN;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHEK1	O14757	239	271	1	265	Region	Note=Interaction with CLSPN;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHEK1	O14757	239	271	1	265	Region	Note=Interaction with CLSPN;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHEK1	O14757	239	271	1	265	Region	Note=Interaction with CLSPN;Ontology_term=ECO:0000250;evidence=ECO:0000250
CHEK1	O14757	411	445	391	476	Region	Note=Autoinhibitory region
CHEK1	O14757	411	445	391	476	Region	Note=Autoinhibitory region
CHEK1	O14757	411	445	391	476	Region	Note=Autoinhibitory region
CHEK1	O14757	411	445	391	476	Region	Note=Autoinhibitory region
CHEK1	O14757	411	445	436	436	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	436	436	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	436	436	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	436	436	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	412	445	Alternative sequence	ID=VSP_045075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHEK1	O14757	411	445	412	445	Alternative sequence	ID=VSP_045075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHEK1	O14757	411	445	412	445	Alternative sequence	ID=VSP_045075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHEK1	O14757	411	445	412	445	Alternative sequence	ID=VSP_045075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHEK1	O14757	411	445	436	436	Mutagenesis	Note=Enhances stability of the protein%2C probably by preventing ubiquitination at this site. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	436	436	Mutagenesis	Note=Enhances stability of the protein%2C probably by preventing ubiquitination at this site. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	436	436	Mutagenesis	Note=Enhances stability of the protein%2C probably by preventing ubiquitination at this site. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	411	445	436	436	Mutagenesis	Note=Enhances stability of the protein%2C probably by preventing ubiquitination at this site. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19716789;Dbxref=PMID:19716789
CHEK1	O14757	239	271	236	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	236	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	236	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	236	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	250	252	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	256	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	256	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	256	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	256	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	263	266	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	263	266	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	263	266	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	239	271	263	266	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YEX
CHEK1	O14757	411	445	403	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	403	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	403	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	403	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	423	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	423	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	423	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	423	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	434	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	434	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	434	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
CHEK1	O14757	411	445	434	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WI2
NDUFAF1	Q9Y375	253	278	25	327	Chain	ID=PRO_0000005464;Note=Complex I intermediate-associated protein 30%2C mitochondrial
C11orf16	Q9NQ32	186	401	1	467	Chain	ID=PRO_0000089832;Note=Uncharacterized protein C11orf16
C11orf16	Q9NQ32	186	401	210	210	Natural variant	ID=VAR_056828;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11042127
C11orf16	Q9NQ32	186	401	311	311	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf16	Q9NQ32	186	401	311	311	Sequence conflict	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf16	Q9NQ32	186	401	398	398	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf16	Q9NQ32	186	401	398	398	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
C11orf16	Q9NQ32	186	401	398	398	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
C10orf90	Q96M02	414	511	1	699	Chain	ID=PRO_0000279492;Note=Centrosomal protein C10orf90
C10orf90	Q96M02	414	511	415	511	Alternative sequence	ID=VSP_023458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CMTM7	Q96FZ5	111	144	1	175	Chain	ID=PRO_0000186110;Note=CKLF-like MARVEL transmembrane domain-containing protein 7
CMTM7	Q96FZ5	111	144	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM7	Q96FZ5	111	144	140	160	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CMTM7	Q96FZ5	111	144	40	166	Domain	Note=MARVEL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00581
CMTM7	Q96FZ5	111	144	112	144	Alternative sequence	ID=VSP_042566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12782130,ECO:0000303|Ref.2;Dbxref=PMID:12782130
CKAP5	Q14008	1563	1623	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	1465	1522	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	1229	1297	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	1179	1229	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	916	954	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	656	718	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	550	588	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	288	326	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	84	152	1	2032	Chain	ID=PRO_0000089663;Note=Cytoskeleton-associated protein 5
CKAP5	Q14008	916	954	936	974	Repeat	Note=HEAT 6
CKAP5	Q14008	1229	1297	1284	1322	Repeat	Note=HEAT 8
CKAP5	Q14008	84	152	1	223	Region	Note=TOG 1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	288	326	268	502	Region	Note=TOG 2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	656	718	588	817	Region	Note=TOG 3;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	550	588	588	817	Region	Note=TOG 3;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	916	954	853	1081	Region	Note=TOG 4;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	1229	1297	1193	1428	Region	Note=TOG 5;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	1179	1229	1193	1428	Region	Note=TOG 5;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24966168;Dbxref=PMID:24966168
CKAP5	Q14008	1465	1522	1469	1469	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CKAP5	Q14008	1563	1623	1564	1623	Alternative sequence	ID=VSP_035668;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8536682;Dbxref=PMID:8536682
CKAP5	Q14008	916	954	914	931	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QMI
CKAP5	Q14008	916	954	932	938	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QMI
CKAP5	Q14008	916	954	939	942	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QMI
CKAP5	Q14008	916	954	943	948	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QMI
CKAP5	Q14008	916	954	949	951	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QMI
CLEC10A	Q8IUN9	93	117	1	316	Chain	ID=PRO_0000046639;Note=C-type lectin domain family 10 member A
CLEC10A	Q8IUN9	93	117	61	316	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC10A	Q8IUN9	93	117	85	176	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC10A	Q8IUN9	93	117	100	100	Natural variant	ID=VAR_050114;Note=T->M;Dbxref=dbSNP:rs35318160
CLEC10A	Q8IUN9	93	117	112	112	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLEC12A	Q5QGZ9	40	73	1	265	Chain	ID=PRO_0000313578;Note=C-type lectin domain family 12 member A
CLEC12A	Q5QGZ9	40	73	1	43	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC12A	Q5QGZ9	40	73	44	64	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC12A	Q5QGZ9	40	73	65	265	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CLEC12A	Q5QGZ9	40	73	31	64	Alternative sequence	ID=VSP_030030;Note=In isoform 4. APPAPSHVWRPAALFLTLLCLLLLIGLGVLASMF->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14739280;Dbxref=PMID:14739280
CLEC12A	Q5QGZ9	40	73	64	81	Alternative sequence	ID=VSP_030031;Note=In isoform 3. FHVTLKIEMKKMNKLQNI->CMYCPCFGQEEVSRISNI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14739280;Dbxref=PMID:14739280
CLCN2	P51788	805	834	2	898	Chain	ID=PRO_0000094433;Note=Chloride channel protein 2
CLCN2	P51788	770	805	2	898	Chain	ID=PRO_0000094433;Note=Chloride channel protein 2
CLCN2	P51788	757	770	2	898	Chain	ID=PRO_0000094433;Note=Chloride channel protein 2
CLCN2	P51788	390	442	2	898	Chain	ID=PRO_0000094433;Note=Chloride channel protein 2
CLCN2	P51788	205	231	2	898	Chain	ID=PRO_0000094433;Note=Chloride channel protein 2
CLCN2	P51788	73	117	2	898	Chain	ID=PRO_0000094433;Note=Chloride channel protein 2
CLCN2	P51788	73	117	2	87	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	73	117	88	121	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	205	231	205	223	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	390	442	429	449	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	805	834	549	898	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	770	805	549	898	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	757	770	549	898	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	805	834	790	850	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCN2	P51788	770	805	790	850	Domain	Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CLCN2	P51788	205	231	203	207	Motif	Note=Selectivity filter part_2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLCN2	P51788	757	770	758	758	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35525
CLCN2	P51788	205	231	1	359	Alternative sequence	ID=VSP_007831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLCN2	P51788	73	117	1	359	Alternative sequence	ID=VSP_007831;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLCN2	P51788	73	117	74	117	Alternative sequence	ID=VSP_045457;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLCN2	P51788	805	834	486	898	Alternative sequence	ID=VSP_036455;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLCN2	P51788	770	805	486	898	Alternative sequence	ID=VSP_036455;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLCN2	P51788	757	770	486	898	Alternative sequence	ID=VSP_036455;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLCN2	P51788	805	834	806	834	Alternative sequence	ID=VSP_045458;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC16A	Q2KHT3	301	319	1	1053	Chain	ID=PRO_0000274476;Note=Protein CLEC16A
CLEC16A	Q2KHT3	622	665	1	1053	Chain	ID=PRO_0000274476;Note=Protein CLEC16A
CLEC16A	Q2KHT3	824	880	1	1053	Chain	ID=PRO_0000274476;Note=Protein CLEC16A
CLEC16A	Q2KHT3	880	935	1	1053	Chain	ID=PRO_0000274476;Note=Protein CLEC16A
CLEC16A	Q2KHT3	880	935	892	933	Compositional bias	Note=Ser-rich
CLEC16A	Q2KHT3	301	319	1	913	Alternative sequence	ID=VSP_022745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC16A	Q2KHT3	622	665	1	913	Alternative sequence	ID=VSP_022745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC16A	Q2KHT3	824	880	1	913	Alternative sequence	ID=VSP_022745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC16A	Q2KHT3	880	935	1	913	Alternative sequence	ID=VSP_022745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC16A	Q2KHT3	880	935	882	924	Alternative sequence	ID=VSP_022748;Note=In isoform 2. FAVAQCINQHSSPSLSSQSPPSASGSPSGSGSTSHCDSGGTSS->EPAPRPAPQLVHHGGRSRSFSLWSLCELPFLSQKPRRLAAPAS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLEC16A	Q2KHT3	880	935	914	935	Alternative sequence	ID=VSP_022749;Note=In isoform 3. TSHCDSGGTSSSSTPSTAQSPA->MAATGFSAPNGSCHGTSRTVNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CLEC16A	Q2KHT3	880	935	925	1053	Alternative sequence	ID=VSP_022750;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CLEC16A	Q2KHT3	880	935	906	906	Natural variant	ID=VAR_030288;Note=G->E;Dbxref=dbSNP:rs2241100
CLDN15	P56746	155	193	1	228	Chain	ID=PRO_0000144771;Note=Claudin-15
CLDN15	P56746	155	193	1	228	Chain	ID=PRO_0000144771;Note=Claudin-15
CLDN15	P56746	72	127	1	228	Chain	ID=PRO_0000144771;Note=Claudin-15
CLDN15	P56746	72	127	25	74	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	72	127	75	99	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	72	127	100	115	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	72	127	116	140	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	155	193	141	159	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	155	193	141	159	Topological domain	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	155	193	160	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	155	193	160	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	155	193	183	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	155	193	183	228	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
CLDN15	P56746	72	127	111	111	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
CLIC4	Q9Y696	61	102	2	253	Chain	ID=PRO_0000144210;Note=Chloride intracellular channel protein 4
CLIC4	Q9Y696	61	102	2	101	Region	Note=Required for insertion into the membrane;Ontology_term=ECO:0000305;evidence=ECO:0000305
CLIC4	Q9Y696	61	102	64	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AHE
CLIC4	Q9Y696	61	102	77	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AHE
CLIC4	Q9Y696	61	102	83	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AHE
CLIC4	Q9Y696	61	102	88	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AHE
CLIC4	Q9Y696	61	102	101	103	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AHE
CDC20	Q12834	359	401	1	499	Chain	ID=PRO_0000050900;Note=Cell division cycle protein 20 homolog
CDC20	Q12834	359	401	1	499	Chain	ID=PRO_0000050900;Note=Cell division cycle protein 20 homolog
CDC20	Q12834	359	401	353	395	Repeat	Note=WD 5
CDC20	Q12834	359	401	353	395	Repeat	Note=WD 5
CDC20	Q12834	359	401	397	438	Repeat	Note=WD 6
CDC20	Q12834	359	401	397	438	Repeat	Note=WD 6
CDC20	Q12834	359	401	358	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	358	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	370	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	370	375	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	377	379	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	377	379	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	381	386	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	381	386	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	387	389	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	387	389	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	392	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CDC20	Q12834	359	401	392	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GGC
CD8A	P01732	171	208	22	235	Chain	ID=PRO_0000014638;Note=T-cell surface glycoprotein CD8 alpha chain
CD8A	P01732	134	171	22	235	Chain	ID=PRO_0000014638;Note=T-cell surface glycoprotein CD8 alpha chain
CD8A	P01732	171	208	22	235	Chain	ID=PRO_0000014638;Note=T-cell surface glycoprotein CD8 alpha chain
CD8A	P01732	134	171	22	235	Chain	ID=PRO_0000014638;Note=T-cell surface glycoprotein CD8 alpha chain
CD8A	P01732	171	208	22	182	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	134	171	22	182	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	171	208	22	182	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	134	171	22	182	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	171	208	183	203	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	171	208	183	203	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	171	208	204	235	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	171	208	204	235	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD8A	P01732	134	171	22	135	Domain	Note=Ig-like V-type
CD8A	P01732	134	171	22	135	Domain	Note=Ig-like V-type
CD8A	P01732	171	208	206	206	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17341584;Dbxref=PMID:17341584
CD8A	P01732	171	208	206	206	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17341584;Dbxref=PMID:17341584
CD8A	P01732	171	208	172	209	Alternative sequence	ID=VSP_012653;Note=In isoform 2. VHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHR->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD8A	P01732	171	208	172	209	Alternative sequence	ID=VSP_012653;Note=In isoform 2. VHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHR->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD8A	P01732	171	208	206	206	Mutagenesis	Note=Complete loss of palmitoylation. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17341584;Dbxref=PMID:17341584
CD8A	P01732	171	208	206	206	Mutagenesis	Note=Complete loss of palmitoylation. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17341584;Dbxref=PMID:17341584
CD5	P06127	366	408	25	495	Chain	ID=PRO_0000033222;Note=T-cell surface glycoprotein CD5
CD5	P06127	366	408	25	372	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD5	P06127	366	408	373	402	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD5	P06127	366	408	403	495	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD5	P06127	366	408	276	368	Domain	Note=SRCR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD5	P06127	366	408	316	367	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:18339402;Dbxref=PMID:18339402
CD5	P06127	366	408	362	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JA4
CDC7	O00311	38	66	1	574	Chain	ID=PRO_0000085763;Note=Cell division cycle 7-related protein kinase
CDC7	O00311	274	306	1	574	Chain	ID=PRO_0000085763;Note=Cell division cycle 7-related protein kinase
CDC7	O00311	393	443	1	574	Chain	ID=PRO_0000085763;Note=Cell division cycle 7-related protein kinase
CDC7	O00311	38	66	1	574	Chain	ID=PRO_0000085763;Note=Cell division cycle 7-related protein kinase
CDC7	O00311	274	306	1	574	Chain	ID=PRO_0000085763;Note=Cell division cycle 7-related protein kinase
CDC7	O00311	393	443	1	574	Chain	ID=PRO_0000085763;Note=Cell division cycle 7-related protein kinase
CDC7	O00311	38	66	58	574	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	274	306	58	574	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	393	443	58	574	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	38	66	58	574	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	274	306	58	574	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	393	443	58	574	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	38	66	64	72	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	38	66	64	72	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDC7	O00311	393	443	441	441	Natural variant	ID=VAR_019259;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.4;Dbxref=dbSNP:rs13447539,PMID:17344846
CDC7	O00311	393	443	441	441	Natural variant	ID=VAR_019259;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.4;Dbxref=dbSNP:rs13447539,PMID:17344846
CDC7	O00311	38	66	42	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	38	66	42	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	38	66	52	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	38	66	52	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	38	66	59	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	38	66	59	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	394	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	394	409	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	412	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	412	415	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	420	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	420	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	433	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CDC7	O00311	393	443	433	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4F9C
CD68	P34810	189	229	22	354	Chain	ID=PRO_0000017102;Note=Macrosialin
CD68	P34810	253	310	22	354	Chain	ID=PRO_0000017102;Note=Macrosialin
CD68	P34810	189	229	22	319	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD68	P34810	253	310	22	319	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD68	P34810	189	229	199	199	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CD68	P34810	253	310	261	261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16263699,ECO:0000269|PubMed:19159218;Dbxref=PMID:16263699,PMID:19159218
CD68	P34810	253	310	279	279	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
CD68	P34810	189	229	169	207	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00740
CD68	P34810	253	310	277	314	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00740
CD68	P34810	253	310	254	254	Natural variant	ID=VAR_016144;Note=Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7680921;Dbxref=dbSNP:rs9901673,PMID:7680921
CDKL3	Q8IVW4	55	120	1	592	Chain	ID=PRO_0000085820;Note=Cyclin-dependent kinase-like 3
CDKL3	Q8IVW4	55	120	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDKL3	Q8IVW4	55	120	45	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDKL3	Q8IVW4	55	120	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDKL3	Q8IVW4	55	120	72	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDKL3	Q8IVW4	55	120	76	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDKL3	Q8IVW4	55	120	83	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDKL3	Q8IVW4	55	120	86	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDKL3	Q8IVW4	55	120	99	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZDU
CDK3	Q00526	162	196	1	305	Chain	ID=PRO_0000085776;Note=Cyclin-dependent kinase 3
CDK3	Q00526	196	264	1	305	Chain	ID=PRO_0000085776;Note=Cyclin-dependent kinase 3
CDK3	Q00526	162	196	1	305	Chain	ID=PRO_0000085776;Note=Cyclin-dependent kinase 3
CDK3	Q00526	196	264	1	305	Chain	ID=PRO_0000085776;Note=Cyclin-dependent kinase 3
CDK3	Q00526	162	196	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK3	Q00526	196	264	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK3	Q00526	162	196	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK3	Q00526	196	264	4	286	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK3	Q00526	196	264	214	214	Natural variant	ID=VAR_041975;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34670267,PMID:17344846
CDK3	Q00526	196	264	214	214	Natural variant	ID=VAR_041975;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34670267,PMID:17344846
CDK3	Q00526	196	264	226	226	Natural variant	ID=VAR_021101;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs2069532
CDK3	Q00526	196	264	226	226	Natural variant	ID=VAR_021101;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs2069532
CDK3	Q00526	196	264	264	264	Natural variant	ID=VAR_021102;Note=M->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs17884251,PMID:17344846
CDK3	Q00526	196	264	264	264	Natural variant	ID=VAR_021102;Note=M->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs17884251,PMID:17344846
CEP350	Q5VT06	377	415	1	3117	Chain	ID=PRO_0000233291;Note=Centrosome-associated protein 350
CEP57L1	Q8IYX8	219	248	1	460	Chain	ID=PRO_0000189534;Note=Centrosomal protein CEP57L1
CEP57L1	Q8IYX8	219	248	1	460	Chain	ID=PRO_0000189534;Note=Centrosomal protein CEP57L1
CEP57L1	Q8IYX8	219	248	51	228	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP57L1	Q8IYX8	219	248	51	228	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEACAM19	Q7Z692	192	219	33	300	Chain	ID=PRO_0000014576;Note=Carcinoembryonic antigen-related cell adhesion molecule 19
CEACAM19	Q7Z692	192	219	179	300	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CEACAM19	Q7Z692	192	219	143	300	Alternative sequence	ID=VSP_010709;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CELA2B	P08218	76	118	29	269	Chain	ID=PRO_0000027696;Note=Chymotrypsin-like elastase family member 2B
CELA2B	P08218	76	118	29	267	Domain	Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274
CELA2B	P08218	76	118	79	79	Natural variant	ID=VAR_044534;Note=G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:3646943;Dbxref=dbSNP:rs3820071,PMID:15489334,PMID:3646943
CELA2B	P08218	76	118	114	114	Natural variant	ID=VAR_044535;Note=D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:3646943;Dbxref=dbSNP:rs3766160,PMID:15489334,PMID:3646943
CERS4	Q9HA82	156	173	1	394	Chain	ID=PRO_0000185512;Note=Ceramide synthase 4
CERS4	Q9HA82	173	204	1	394	Chain	ID=PRO_0000185512;Note=Ceramide synthase 4
CERS4	Q9HA82	204	247	1	394	Chain	ID=PRO_0000185512;Note=Ceramide synthase 4
CERS4	Q9HA82	156	173	1	394	Chain	ID=PRO_0000185512;Note=Ceramide synthase 4
CERS4	Q9HA82	173	204	1	394	Chain	ID=PRO_0000185512;Note=Ceramide synthase 4
CERS4	Q9HA82	204	247	1	394	Chain	ID=PRO_0000185512;Note=Ceramide synthase 4
CERS4	Q9HA82	156	173	140	160	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS4	Q9HA82	156	173	140	160	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS4	Q9HA82	173	204	179	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS4	Q9HA82	173	204	179	199	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS4	Q9HA82	204	247	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS4	Q9HA82	204	247	209	229	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CERS4	Q9HA82	156	173	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS4	Q9HA82	173	204	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS4	Q9HA82	204	247	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS4	Q9HA82	156	173	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS4	Q9HA82	173	204	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
CERS4	Q9HA82	204	247	131	332	Domain	Note=TLC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00205
DCST2	Q5T1A1	392	447	1	773	Chain	ID=PRO_0000278826;Note=DC-STAMP domain-containing protein 2
DCST2	Q5T1A1	392	447	344	415	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCST2	Q5T1A1	392	447	416	436	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCST2	Q5T1A1	392	447	437	499	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CHCHD7	Q9BUK0	18	51	1	85	Chain	ID=PRO_0000129171;Note=Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
CHCHD7	Q9BUK0	18	51	13	55	Domain	Note=CHCH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CHCHD7	Q9BUK0	18	51	16	26	Motif	Note=Cx9C motif 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CHCHD7	Q9BUK0	18	51	37	47	Motif	Note=Cx9C motif 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01150
CHCHD7	Q9BUK0	18	51	16	47	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01150,ECO:0000269|PubMed:22842048;Dbxref=PMID:22842048
CHCHD7	Q9BUK0	18	51	26	37	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01150,ECO:0000269|PubMed:22842048;Dbxref=PMID:22842048
CHCHD7	Q9BUK0	18	51	19	85	Alternative sequence	ID=VSP_038077;Note=In isoform 3 and isoform 5. ESDASTRCLDENNYDRERCSTYFLRYKNCRRFWNSIVMQRRKNGVKPFMPTAAERDEILRAVGNMPY->ILFYLLNDASLISVRNLMLPPDVWMKITMTGKGVPLTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
CHCHD7	Q9BUK0	18	51	17	29	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQT
CHCHD7	Q9BUK0	18	51	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQT
CHCHD7	Q9BUK0	18	51	34	37	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQT
CHCHD7	Q9BUK0	18	51	38	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LQT
DDX56	Q9NY93	297	336	1	547	Chain	ID=PRO_0000055058;Note=Probable ATP-dependent RNA helicase DDX56
DDX56	Q9NY93	297	336	230	424	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX56	Q9NY93	297	336	298	337	Alternative sequence	ID=VSP_044869;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHMP7	Q8WUX9	280	320	1	453	Chain	ID=PRO_0000211516;Note=Charged multivesicular body protein 7
CHMP7	Q8WUX9	280	320	1	453	Chain	ID=PRO_0000211516;Note=Charged multivesicular body protein 7
CHMP7	Q8WUX9	280	320	243	312	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CHMP7	Q8WUX9	280	320	243	312	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CHMP7	Q8WUX9	280	320	163	452	Alternative sequence	ID=VSP_056946;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CHMP7	Q8WUX9	280	320	163	452	Alternative sequence	ID=VSP_056946;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBLB	Q13191	856	896	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	809	856	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	765	809	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	685	733	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	531	653	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	401	469	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	140	188	1	982	Chain	ID=PRO_0000055860;Note=E3 ubiquitin-protein ligase CBL-B
CBLB	Q13191	140	188	35	343	Domain	Note=Cbl-PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00839
CBLB	Q13191	401	469	373	412	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
CBLB	Q13191	140	188	35	167	Region	Note=4H
CBLB	Q13191	140	188	168	240	Region	Note=EF-hand-like
CBLB	Q13191	531	653	543	568	Region	Note=Interaction with VAV1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9399639;Dbxref=PMID:9399639
CBLB	Q13191	856	896	891	927	Region	Note=Interaction with SH3KBP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12177062;Dbxref=PMID:12177062
CBLB	Q13191	856	896	477	925	Compositional bias	Note=Pro-rich
CBLB	Q13191	809	856	477	925	Compositional bias	Note=Pro-rich
CBLB	Q13191	765	809	477	925	Compositional bias	Note=Pro-rich
CBLB	Q13191	685	733	477	925	Compositional bias	Note=Pro-rich
CBLB	Q13191	531	653	477	925	Compositional bias	Note=Pro-rich
CBLB	Q13191	531	653	634	634	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K4S7
CBLB	Q13191	685	733	709	709	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10022120;Dbxref=PMID:10022120
CBLB	Q13191	856	896	889	889	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TTA7
CBLB	Q13191	765	809	767	770	Alternative sequence	ID=VSP_005730;Note=In isoform Truncated 2. DVFD->TYRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7784085;Dbxref=PMID:7784085
CBLB	Q13191	856	896	771	982	Alternative sequence	ID=VSP_005731;Note=In isoform Truncated 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7784085;Dbxref=PMID:7784085
CBLB	Q13191	809	856	771	982	Alternative sequence	ID=VSP_005731;Note=In isoform Truncated 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7784085;Dbxref=PMID:7784085
CBLB	Q13191	765	809	771	982	Alternative sequence	ID=VSP_005731;Note=In isoform Truncated 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7784085;Dbxref=PMID:7784085
CBLB	Q13191	856	896	811	982	Alternative sequence	ID=VSP_005729;Note=In isoform Truncated 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7784085;Dbxref=PMID:7784085
CBLB	Q13191	809	856	811	982	Alternative sequence	ID=VSP_005729;Note=In isoform Truncated 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7784085;Dbxref=PMID:7784085
CBLB	Q13191	531	653	584	584	Natural variant	ID=VAR_025303;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853100,PMID:15489334
CBLB	Q13191	856	896	883	883	Natural variant	ID=VAR_039241;Note=N->D;Dbxref=dbSNP:rs35835913
CBLB	Q13191	685	733	709	709	Mutagenesis	Note=Inhibits interaction with CRKL. Abolishes interaction with CRKL%3B when associated with F-665. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10022120;Dbxref=PMID:10022120
CBLB	Q13191	140	188	138	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	140	188	162	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	140	188	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	140	188	176	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	401	469	394	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	401	469	409	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	401	469	417	420	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CBLB	Q13191	401	469	422	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNI
CCDC110	Q8TBZ0	79	116	1	833	Chain	ID=PRO_0000249076;Note=Coiled-coil domain-containing protein 110
CCDC110	Q8TBZ0	79	116	80	116	Alternative sequence	ID=VSP_020365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC113	Q9H0I3	76	130	1	377	Chain	ID=PRO_0000279399;Note=Coiled-coil domain-containing protein 113
CCDC113	Q9H0I3	209	261	1	377	Chain	ID=PRO_0000279399;Note=Coiled-coil domain-containing protein 113
CCDC113	Q9H0I3	261	297	1	377	Chain	ID=PRO_0000279399;Note=Coiled-coil domain-containing protein 113
CCDC113	Q9H0I3	76	130	95	243	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC113	Q9H0I3	209	261	95	243	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC113	Q9H0I3	261	297	280	354	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC113	Q9H0I3	76	130	77	130	Alternative sequence	ID=VSP_042753;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD3	Q5JTY5	143	163	1	395	Chain	ID=PRO_0000317238;Note=COBW domain-containing protein 3
CBWD3	Q5JTY5	192	220	1	395	Chain	ID=PRO_0000317238;Note=COBW domain-containing protein 3
CBWD3	Q5JTY5	236	254	1	395	Chain	ID=PRO_0000317238;Note=COBW domain-containing protein 3
CBWD3	Q5JTY5	192	220	203	206	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
CBWD3	Q5JTY5	143	163	145	164	Alternative sequence	ID=VSP_055975;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD5	Q5RIA9	272	295	1	395	Chain	ID=PRO_0000317239;Note=COBW domain-containing protein 5
CBWD5	Q5RIA9	236	254	1	395	Chain	ID=PRO_0000317239;Note=COBW domain-containing protein 5
CBWD5	Q5RIA9	221	235	1	395	Chain	ID=PRO_0000317239;Note=COBW domain-containing protein 5
CBWD5	Q5RIA9	192	220	1	395	Chain	ID=PRO_0000317239;Note=COBW domain-containing protein 5
CBWD5	Q5RIA9	143	163	1	395	Chain	ID=PRO_0000317239;Note=COBW domain-containing protein 5
CBWD5	Q5RIA9	272	295	274	377	Domain	Note=CobW C-terminal
CBWD5	Q5RIA9	192	220	203	206	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
CBWD5	Q5RIA9	272	295	1	291	Alternative sequence	ID=VSP_033808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD5	Q5RIA9	236	254	1	291	Alternative sequence	ID=VSP_033808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD5	Q5RIA9	221	235	1	291	Alternative sequence	ID=VSP_033808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD5	Q5RIA9	192	220	1	291	Alternative sequence	ID=VSP_033808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD5	Q5RIA9	143	163	1	291	Alternative sequence	ID=VSP_033808;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CBWD5	Q5RIA9	192	220	192	220	Alternative sequence	ID=VSP_040475;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CBWD5	Q5RIA9	236	254	236	254	Alternative sequence	ID=VSP_040476;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CBWD5	Q5RIA9	143	163	147	147	Natural variant	ID=VAR_067710;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs7874545,PMID:15489334
CBWD5	Q5RIA9	272	295	288	288	Natural variant	ID=VAR_067711;Note=E->D;Dbxref=dbSNP:rs1127334
CCDC85C	A6NKD9	325	357	2	419	Chain	ID=PRO_0000345410;Note=Coiled-coil domain-containing protein 85C
CCDC85C	A6NKD9	289	325	2	419	Chain	ID=PRO_0000345410;Note=Coiled-coil domain-containing protein 85C
CCDC150	Q8NCX0	215	254	1	1101	Chain	ID=PRO_0000328984;Note=Coiled-coil domain-containing protein 150
CCDC150	Q8NCX0	312	343	1	1101	Chain	ID=PRO_0000328984;Note=Coiled-coil domain-containing protein 150
CCDC150	Q8NCX0	480	503	1	1101	Chain	ID=PRO_0000328984;Note=Coiled-coil domain-containing protein 150
CCDC150	Q8NCX0	503	541	1	1101	Chain	ID=PRO_0000328984;Note=Coiled-coil domain-containing protein 150
CCDC150	Q8NCX0	852	917	1	1101	Chain	ID=PRO_0000328984;Note=Coiled-coil domain-containing protein 150
CCDC150	Q8NCX0	215	254	106	299	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC150	Q8NCX0	480	503	398	680	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC150	Q8NCX0	503	541	398	680	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC150	Q8NCX0	852	917	712	940	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC150	Q8NCX0	215	254	1	685	Alternative sequence	ID=VSP_032872;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CCDC150	Q8NCX0	312	343	1	685	Alternative sequence	ID=VSP_032872;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CCDC150	Q8NCX0	480	503	1	685	Alternative sequence	ID=VSP_032872;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CCDC150	Q8NCX0	503	541	1	685	Alternative sequence	ID=VSP_032872;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CCDC150	Q8NCX0	215	254	1	513	Alternative sequence	ID=VSP_032873;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
CCDC150	Q8NCX0	312	343	1	513	Alternative sequence	ID=VSP_032873;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
CCDC150	Q8NCX0	480	503	1	513	Alternative sequence	ID=VSP_032873;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
CCDC150	Q8NCX0	503	541	1	513	Alternative sequence	ID=VSP_032873;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
CCDC150	Q8NCX0	503	541	514	622	Alternative sequence	ID=VSP_032874;Note=In isoform 2. QTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKE->MPLRKRKSPERTASSKSPEISRSHVNSIKERTSSVGLPSVIPNSTRRVSFAPNLPSMKTSQDIGDSRISLKTLLNAIKTMEGRLEGKIEILASRPLINDESPNFLKQDS;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
CCDC150	Q8NCX0	852	917	853	853	Alternative sequence	ID=VSP_032875;Note=In isoform 4. L->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC150	Q8NCX0	852	917	854	1101	Alternative sequence	ID=VSP_032876;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC151	A5D8V7	204	238	1	595	Chain	ID=PRO_0000321526;Note=Coiled-coil domain-containing protein 151
CCDC151	A5D8V7	122	148	1	595	Chain	ID=PRO_0000321526;Note=Coiled-coil domain-containing protein 151
CCDC151	A5D8V7	204	238	94	327	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC151	A5D8V7	122	148	94	327	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC154	A6NI56	544	571	1	674	Chain	ID=PRO_0000332270;Note=Coiled-coil domain-containing protein 154
CCDC154	A6NI56	393	439	1	674	Chain	ID=PRO_0000332270;Note=Coiled-coil domain-containing protein 154
CCDC154	A6NI56	152	183	1	674	Chain	ID=PRO_0000332270;Note=Coiled-coil domain-containing protein 154
CCDC154	A6NI56	152	183	76	182	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC154	A6NI56	393	439	393	419	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC154	A6NI56	544	571	544	544	Alternative sequence	ID=VSP_047468;Note=In isoform 2. T->TFQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22895184;Dbxref=PMID:22895184
CCDC73	Q6ZRK6	130	143	1	1079	Chain	ID=PRO_0000285294;Note=Coiled-coil domain-containing protein 73
CCDC73	Q6ZRK6	45	69	1	1079	Chain	ID=PRO_0000285294;Note=Coiled-coil domain-containing protein 73
CCDC73	Q6ZRK6	130	143	59	210	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC73	Q6ZRK6	45	69	59	210	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCNG1	P51959	0	88	1	295	Chain	ID=PRO_0000080465;Note=Cyclin-G1
CCNG1	P51959	199	232	1	295	Chain	ID=PRO_0000080465;Note=Cyclin-G1
CCNG1	P51959	0	88	1	295	Chain	ID=PRO_0000080465;Note=Cyclin-G1
CCNG1	P51959	199	232	1	295	Chain	ID=PRO_0000080465;Note=Cyclin-G1
CCNG1	P51959	0	88	1	134	Alternative sequence	ID=VSP_056943;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCNG1	P51959	0	88	1	134	Alternative sequence	ID=VSP_056943;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCNT1	O60563	81	124	1	726	Chain	ID=PRO_0000080491;Note=Cyclin-T1
CCNT1	O60563	81	124	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
CCNT1	O60563	81	124	80	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MI9
CCNT1	O60563	81	124	101	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MI9
CCNT1	O60563	81	124	114	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MI9
CCNT1	O60563	81	124	124	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MI9
CDC73	Q6P1J9	243	276	2	531	Chain	ID=PRO_0000191803;Note=Parafibromin
CDC73	Q6P1J9	343	355	2	531	Chain	ID=PRO_0000191803;Note=Parafibromin
CDC73	Q6P1J9	385	438	2	531	Chain	ID=PRO_0000191803;Note=Parafibromin
CDC73	Q6P1J9	243	276	200	531	Region	Note=Interaction with POLR2A and PAF1
CDC73	Q6P1J9	343	355	200	531	Region	Note=Interaction with POLR2A and PAF1
CDC73	Q6P1J9	385	438	200	531	Region	Note=Interaction with POLR2A and PAF1
CDC73	Q6P1J9	243	276	200	250	Region	Note=Interaction with CTNNB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16630820;Dbxref=PMID:16630820
CDC73	Q6P1J9	243	276	272	272	Natural variant	ID=VAR_064934;Note=Found in a parathyroid adenoma sample. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16728578;Dbxref=dbSNP:rs752383339,PMID:16728578
CDCP1	Q9H5V8	542	664	30	836	Chain	ID=PRO_0000226249;Note=CUB domain-containing protein 1
CDCP1	Q9H5V8	341	415	30	836	Chain	ID=PRO_0000226249;Note=CUB domain-containing protein 1
CDCP1	Q9H5V8	97	218	30	836	Chain	ID=PRO_0000226249;Note=CUB domain-containing protein 1
CDCP1	Q9H5V8	542	664	30	667	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	341	415	30	667	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	97	218	30	667	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	542	664	417	544	Domain	Note=CUB
CDCP1	Q9H5V8	341	415	368	369	Site	Note=Cleavage%3B by ST14/MT-SP1
CDCP1	Q9H5V8	97	218	122	122	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	97	218	180	180	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	97	218	205	205	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	341	415	386	386	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDCP1	Q9H5V8	97	218	1	187	Alternative sequence	ID=VSP_017432;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDCP1	Q9H5V8	341	415	342	343	Alternative sequence	ID=VSP_017433;Note=In isoform 3. NK->SE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
CDCP1	Q9H5V8	542	664	344	836	Alternative sequence	ID=VSP_017434;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
CDCP1	Q9H5V8	341	415	344	836	Alternative sequence	ID=VSP_017434;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
CDK16	Q00536	154	173	1	496	Chain	ID=PRO_0000086484;Note=Cyclin-dependent kinase 16
CDK16	Q00536	458	484	1	496	Chain	ID=PRO_0000086484;Note=Cyclin-dependent kinase 16
CDK16	Q00536	154	173	1	496	Chain	ID=PRO_0000086484;Note=Cyclin-dependent kinase 16
CDK16	Q00536	458	484	1	496	Chain	ID=PRO_0000086484;Note=Cyclin-dependent kinase 16
CDK16	Q00536	154	173	165	446	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK16	Q00536	154	173	165	446	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK16	Q00536	154	173	171	179	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK16	Q00536	154	173	171	179	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK16	Q00536	154	173	155	155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CDK16	Q00536	154	173	155	155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CDK16	Q00536	154	173	165	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G6V
CDK16	Q00536	154	173	165	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G6V
CDK16	Q00536	458	484	462	465	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G6V
CDK16	Q00536	458	484	462	465	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G6V
CDK6	Q00534	216	232	1	326	Chain	ID=PRO_0000085789;Note=Cyclin-dependent kinase 6
CDK6	Q00534	216	232	1	326	Chain	ID=PRO_0000085789;Note=Cyclin-dependent kinase 6
CDK6	Q00534	216	232	13	300	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK6	Q00534	216	232	13	300	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK6	Q00534	216	232	224	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BLX
CDK6	Q00534	216	232	224	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BLX
CENPA	P49450	70	96	2	140	Chain	ID=PRO_0000221373;Note=Histone H3-like centromeric protein A
CENPA	P49450	70	96	75	116	Region	Note=CATD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15282608,ECO:0000269|PubMed:7962047;Dbxref=PMID:15282608,PMID:7962047
CENPA	P49450	70	96	71	96	Alternative sequence	ID=VSP_020430;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CENPA	P49450	70	96	80	81	Mutagenesis	Note=Impairs retention at centromeres%2C but not targeting to centromeres. RG->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21743476;Dbxref=PMID:21743476
CENPA	P49450	70	96	64	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NQJ
CENPA	P49450	70	96	85	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R45
CENPA	P49450	70	96	88	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NQJ
CENPC	Q03188	763	806	1	943	Chain	ID=PRO_0000089474;Note=Centromere protein C
CENPC	Q03188	710	728	1	943	Chain	ID=PRO_0000089474;Note=Centromere protein C
CENPC	Q03188	763	806	780	798	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPC	Q03188	710	728	710	710	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
CENPC	Q03188	763	806	763	763	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
CENPC	Q03188	763	806	773	773	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
CENPC	Q03188	710	728	727	727	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CENPC	Q03188	763	806	543	943	Alternative sequence	ID=VSP_057281;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CENPC	Q03188	710	728	543	943	Alternative sequence	ID=VSP_057281;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CENPM	Q9NSP4	46	76	1	180	Chain	ID=PRO_0000058224;Note=Centromere protein M
CENPM	Q9NSP4	46	76	1	122	Alternative sequence	ID=VSP_017726;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16391015;Dbxref=PMID:16391015
CENPM	Q9NSP4	46	76	44	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P0T
CENPM	Q9NSP4	46	76	65	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P0T
CENPM	Q9NSP4	46	76	75	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P0T
CENPH	Q9H3R5	80	104	1	247	Chain	ID=PRO_0000089478;Note=Centromere protein H
CENPH	Q9H3R5	80	104	47	192	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP76	Q8TAP6	311	374	1	659	Chain	ID=PRO_0000089501;Note=Centrosomal protein of 76 kDa
CEP76	Q8TAP6	268	311	1	659	Chain	ID=PRO_0000089501;Note=Centrosomal protein of 76 kDa
CEP76	Q8TAP6	173	235	1	659	Chain	ID=PRO_0000089501;Note=Centrosomal protein of 76 kDa
CEP76	Q8TAP6	173	235	1	178	Alternative sequence	ID=VSP_037610;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CEP76	Q8TAP6	173	235	99	174	Alternative sequence	ID=VSP_037611;Note=In isoform 2. TNIDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQVCSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHRESLG->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CEP76	Q8TAP6	311	374	314	314	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAPZB	P47756	1	31	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895,ECO:0000244|PubMed:22814378,ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:12665801;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378,PMID:25944712,PMID:12665801
CAPZB	P47756	157	196	2	277	Chain	ID=PRO_0000204634;Note=F-actin-capping protein subunit beta
CAPZB	P47756	72	109	2	277	Chain	ID=PRO_0000204634;Note=F-actin-capping protein subunit beta
CAPZB	P47756	1	31	2	277	Chain	ID=PRO_0000204634;Note=F-actin-capping protein subunit beta
CAPZB	P47756	1	31	2	2	Modified residue	Note=N-acetylserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895,ECO:0000244|PubMed:22814378,ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:12665801;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378,PMID:25944712,PMID:12665801
CAPZB	P47756	1	31	2	2	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCDC81	Q6ZN84	323	371	1	652	Chain	ID=PRO_0000288877;Note=Coiled-coil domain-containing protein 81
CCDC81	Q6ZN84	323	371	324	371	Alternative sequence	ID=VSP_025807;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039
CCDC22	O60826	303	324	1	627	Chain	ID=PRO_0000076199;Note=Coiled-coil domain-containing protein 22
CCDC22	O60826	364	404	1	627	Chain	ID=PRO_0000076199;Note=Coiled-coil domain-containing protein 22
CCDC22	O60826	513	545	1	627	Chain	ID=PRO_0000076199;Note=Coiled-coil domain-containing protein 22
CCDC22	O60826	303	324	1	447	Region	Note=Sufficicient and required for interaction with CCDC93;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947
CCDC22	O60826	364	404	1	447	Region	Note=Sufficicient and required for interaction with CCDC93;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947
CCDC22	O60826	303	324	1	321	Region	Note=Sufficient for interaction with COMMD1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947
CCDC22	O60826	513	545	447	535	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC24	Q8N4L8	101	139	1	307	Chain	ID=PRO_0000233666;Note=Coiled-coil domain-containing protein 24
CCDC24	Q8N4L8	140	165	1	307	Chain	ID=PRO_0000233666;Note=Coiled-coil domain-containing protein 24
DIABLO	Q9NR28	61	105	56	239	Chain	ID=PRO_0000021072;Note=Diablo homolog%2C mitochondrial
DIABLO	Q9NR28	61	105	62	105	Alternative sequence	ID=VSP_042785;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14523016;Dbxref=PMID:14523016
DIABLO	Q9NR28	61	105	71	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TX5
CCNYL1	Q8N7R7	73	98	1	359	Chain	ID=PRO_0000309321;Note=Cyclin-Y-like protein 1
CCNYL1	Q8N7R7	144	155	1	359	Chain	ID=PRO_0000309321;Note=Cyclin-Y-like protein 1
CCNYL1	Q8N7R7	144	155	145	267	Domain	Note=Cyclin N-terminal
CCNYL1	Q8N7R7	144	155	111	173	Alternative sequence	ID=VSP_029134;Note=In isoform 2. VSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTVKCVTLAIYYHIKNRDANRSLDIFDERSHPLT->CDLSNILPHKEQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC158	Q5M9N0	937	956	1	1113	Chain	ID=PRO_0000325760;Note=Coiled-coil domain-containing protein 158
CCDC158	Q5M9N0	673	724	1	1113	Chain	ID=PRO_0000325760;Note=Coiled-coil domain-containing protein 158
CCDC158	Q5M9N0	268	304	1	1113	Chain	ID=PRO_0000325760;Note=Coiled-coil domain-containing protein 158
CCDC158	Q5M9N0	673	724	243	833	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC158	Q5M9N0	268	304	243	833	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC158	Q5M9N0	937	956	948	1056	Compositional bias	Note=Ser-rich
CCDC158	Q5M9N0	937	956	368	947	Alternative sequence	ID=VSP_032391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC158	Q5M9N0	673	724	368	947	Alternative sequence	ID=VSP_032391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC158	Q5M9N0	937	956	407	1113	Alternative sequence	ID=VSP_032392;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC158	Q5M9N0	673	724	407	1113	Alternative sequence	ID=VSP_032392;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC158	Q5M9N0	268	304	297	297	Natural variant	ID=VAR_039910;Note=I->V;Dbxref=dbSNP:rs17001885
CD320	Q9NPF0	89	167	36	282	Chain	ID=PRO_0000045798;Note=CD320 antigen
CD320	Q9NPF0	89	167	36	229	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD320	Q9NPF0	89	167	53	90	Domain	Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
CD320	Q9NPF0	89	167	131	168	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
CD320	Q9NPF0	89	167	101	104	Compositional bias	Note=Poly-Pro
CD320	Q9NPF0	89	167	150	150	Metal binding	Note=Calcium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	153	153	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	155	155	Metal binding	Note=Calcium 2%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	157	157	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	163	163	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	164	164	Metal binding	Note=Calcium 2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	126	126	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD320	Q9NPF0	89	167	74	89	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	132	145	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000244|PDB:4ZRQ,ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	139	158	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000244|PDB:4ZRQ,ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	152	167	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:4ZRP,ECO:0000244|PDB:4ZRQ,ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:27411955;Dbxref=PMID:27411955
CD320	Q9NPF0	89	167	49	90	Alternative sequence	ID=VSP_045368;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CD320	Q9NPF0	89	167	142	142	Natural variant	ID=VAR_077921;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20524213;Dbxref=PMID:20524213
CD320	Q9NPF0	89	167	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
CD320	Q9NPF0	89	167	140	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRQ
CD320	Q9NPF0	89	167	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
CD320	Q9NPF0	89	167	148	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
CD320	Q9NPF0	89	167	153	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
CD320	Q9NPF0	89	167	162	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZRP
CD79B	P40259	39	143	29	229	Chain	ID=PRO_0000014560;Note=B-cell antigen receptor complex-associated protein beta chain
CD79B	P40259	39	143	29	159	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD79B	P40259	39	143	38	138	Domain	Note=Ig-like V-type
CD79B	P40259	39	143	73	73	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD79B	P40259	39	143	101	101	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD79B	P40259	39	143	127	127	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD79B	P40259	39	143	128	128	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD79B	P40259	39	143	43	126	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394
CD79B	P40259	39	143	65	122	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394
CD79B	P40259	39	143	136	136	Disulfide bond	Note=Interchain (with C-119 in alpha chain);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:20696394;Dbxref=PMID:20696394
CD79B	P40259	39	143	41	144	Alternative sequence	ID=VSP_002477;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7643857,ECO:0000303|Ref.6;Dbxref=PMID:7643857
CD79B	P40259	39	143	137	137	Natural variant	ID=VAR_057833;Note=In AGM6. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17675462;Dbxref=dbSNP:rs121912424,PMID:17675462
CD79B	P40259	39	143	58	58	Sequence conflict	Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD79B	P40259	39	143	58	58	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD79B	P40259	39	143	84	84	Sequence conflict	Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD79B	P40259	39	143	47	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	51	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	75	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	93	95	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	96	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	102	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	114	116	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	118	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	127	129	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CD79B	P40259	39	143	138	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KG5
CDCA5	Q96FF9	69	81	1	252	Chain	ID=PRO_0000089449;Note=Sororin
CDCA5	Q96FF9	69	81	75	75	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18220336,PMID:20068231,PMID:23186163
CDCA5	Q96FF9	69	81	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
CDC27	P30260	720	745	1	824	Chain	ID=PRO_0000106273;Note=Cell division cycle protein 27 homolog
CDC27	P30260	84	125	1	824	Chain	ID=PRO_0000106273;Note=Cell division cycle protein 27 homolog
CDC27	P30260	84	125	67	99	Repeat	Note=TPR 3
CDC27	P30260	84	125	115	145	Repeat	Note=TPR 4
CDC27	P30260	720	745	704	734	Repeat	Note=TPR 12
CDC27	P30260	720	745	737	768	Repeat	Note=TPR 13
CDC27	P30260	84	125	85	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
CDC27	P30260	84	125	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
CDC27	P30260	84	125	103	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
CDC27	P30260	84	125	111	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
CDC27	P30260	84	125	114	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
CDC27	P30260	720	745	719	732	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
CDC27	P30260	720	745	733	735	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
CDC27	P30260	720	745	737	748	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RG9
C5orf22	Q49AR2	269	290	1	442	Chain	ID=PRO_0000305002;Note=UPF0489 protein C5orf22
C5orf22	Q49AR2	269	290	1	279	Alternative sequence	ID=VSP_028182;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
C5orf22	Q49AR2	269	290	280	353	Alternative sequence	ID=VSP_028184;Note=In isoform 3. QFKKPGTNLTEEDLVDIVDTRIHQLEDLEATFADLCDGDDEETVQRWASNPGMESLVPLVQSLKKRMEVPDYEM->MEVPDYEMFPASSSSPSETTSAWISLSMSLSAFWSKPFNKSLGSSKLSNISLPSSEPSKLFQPLPVPKLLPHFQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CEP152	O94986	1062	1118	1	1710	Chain	ID=PRO_0000089462;Note=Centrosomal protein of 152 kDa
CEP152	O94986	1062	1118	1106	1106	Natural variant	ID=VAR_050781;Note=V->A;Dbxref=dbSNP:rs16961557
CEACAM3	P40198	209	231	35	252	Chain	ID=PRO_0000014565;Note=Carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM3	P40198	209	231	177	252	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CEACAM3	P40198	209	231	142	252	Alternative sequence	ID=VSP_002486;Note=In isoform 2. QENAPGLPVGAVAGIVTGVLVGVALVAALVCFLLLAKTGRTSIQRDLKEQQPQALAPGRGPSHSSAFSMSPLSTAQAPLPNPRTAASIYEELLKHDTNIYCRMDHKAEVAS->PELPKPSISSNNSNPKEDKDAVAFTCEPEIHSTTCL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2050678;Dbxref=PMID:2050678
CEACAM3	P40198	209	231	182	252	Alternative sequence	ID=VSP_002487;Note=In isoform 3. TSIQRDLKEQQPQALAPGRGPSHSSAFSMSPLSTAQAPLPNPRTAASIYEELLKHDTNIYCRMDHKAEVAS->PWSLPQLCLLDVPSLHCPGPPTQPQDSSFHL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8508798;Dbxref=PMID:8508798
CEACAM3	P40198	209	231	230	230	Mutagenesis	Note=Loss of phosphorylation and 30%25 reduction in bacterial uptake. More than 60%25 reduction in bacterial uptake and loss of RAC1 stimulation%3B when associated with F-241. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12864848,ECO:0000269|PubMed:14707113;Dbxref=PMID:12864848,PMID:14707113
CEACAM3	P40198	209	231	215	215	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CELF6	Q96J87	364	391	1	481	Chain	ID=PRO_0000295229;Note=CUGBP Elav-like family member 6
CELF6	Q96J87	364	391	344	364	Alternative sequence	ID=VSP_043244;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CELF6	Q96J87	364	391	365	391	Alternative sequence	ID=VSP_043245;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CELSR3	Q9NYQ7	1878	1917	33	3312	Chain	ID=PRO_0000012918;Note=Cadherin EGF LAG seven-pass G-type receptor 3
CELSR3	Q9NYQ7	1878	1917	33	2540	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CELSR3	Q9NYQ7	1878	1917	1764	1944	Domain	Note=Laminin G-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122
CELSR3	Q9NYQ7	1878	1917	1915	1944	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CENPL	Q8N0S6	140	321	1	344	Chain	ID=PRO_0000247170;Note=Centromere protein L
CENPL	Q8N0S6	140	321	1	344	Chain	ID=PRO_0000247170;Note=Centromere protein L
CENPL	Q8N0S6	140	321	140	140	Alternative sequence	ID=VSP_019939;Note=In isoform 2. Q->QGLILSPRLEYSGTILVDCNLCLLGSSDPSTLAFQVAGTAGACHHTR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CENPL	Q8N0S6	140	321	140	140	Alternative sequence	ID=VSP_019939;Note=In isoform 2. Q->QGLILSPRLEYSGTILVDCNLCLLGSSDPSTLAFQVAGTAGACHHTR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CENPL	Q8N0S6	140	321	141	188	Alternative sequence	ID=VSP_019940;Note=In isoform 3. IVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANG->GLILSPRLEYSGTILVDCNLCLLGSSDPSTLAFQVAGTADCVKISIAI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPL	Q8N0S6	140	321	141	188	Alternative sequence	ID=VSP_019940;Note=In isoform 3. IVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANG->GLILSPRLEYSGTILVDCNLCLLGSSDPSTLAFQVAGTADCVKISIAI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPL	Q8N0S6	140	321	189	344	Alternative sequence	ID=VSP_019941;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPL	Q8N0S6	140	321	189	344	Alternative sequence	ID=VSP_019941;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPE	Q02224	2240	2308	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	2174	2240	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	1971	2068	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	1768	1821	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	1715	1768	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	1471	1524	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	1011	1079	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	549	574	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	119	159	1	2698	Chain	ID=PRO_0000125436;Note=Centromere-associated protein E
CENPE	Q02224	119	159	6	329	Domain	Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283
CENPE	Q02224	2240	2308	2126	2476	Region	Note=Kinetochore-binding domain
CENPE	Q02224	2174	2240	2126	2476	Region	Note=Kinetochore-binding domain
CENPE	Q02224	2240	2308	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	2174	2240	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	1971	2068	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	1768	1821	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	1715	1768	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	1471	1524	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	1011	1079	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	549	574	336	2590	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPE	Q02224	549	574	549	573	Alternative sequence	ID=VSP_028820;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CENPE	Q02224	1971	2068	1972	2068	Alternative sequence	ID=VSP_028821;Note=In isoform 3. IQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR->Q;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CENPE	Q02224	549	574	566	566	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPE	Q02224	1971	2068	2008	2017	Sequence conflict	Note=AQNLSMQSVR->PNYLCKCE;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPE	Q02224	2174	2240	2190	2190	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPE	Q02224	119	159	117	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T5C
CENPE	Q02224	119	159	123	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T5C
CENPE	Q02224	119	159	138	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T5C
CENPE	Q02224	119	159	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T5C
CENPJ	Q9HC77	1122	1159	1	1338	Chain	ID=PRO_0000089480;Note=Centromere protein J
CENPJ	Q9HC77	189	288	1	1338	Chain	ID=PRO_0000089480;Note=Centromere protein J
CENPJ	Q9HC77	1122	1159	895	1338	Region	Note=Interaction with STIL;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22020124,ECO:0000269|PubMed:25385835;Dbxref=PMID:22020124,PMID:25385835
CENPJ	Q9HC77	189	288	260	260	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CENPJ	Q9HC77	1122	1159	1087	1338	Alternative sequence	ID=VSP_056832;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CENPJ	Q9HC77	1122	1159	1142	1142	Sequence conflict	Note=E->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CENPK	Q9BS16	124	156	1	269	Chain	ID=PRO_0000249482;Note=Centromere protein K
CENPK	Q9BS16	124	156	1	269	Chain	ID=PRO_0000249482;Note=Centromere protein K
CENPK	Q9BS16	124	156	1	269	Chain	ID=PRO_0000249482;Note=Centromere protein K
CENPK	Q9BS16	124	156	98	151	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPK	Q9BS16	124	156	98	151	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CENPK	Q9BS16	124	156	98	151	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
C6orf106	Q9H6K1	104	170	1	298	Chain	ID=PRO_0000089519;Note=Uncharacterized protein C6orf106
C6orf106	Q9H6K1	104	170	105	170	Alternative sequence	ID=VSP_017259;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C6orf118	Q5T5N4	292	312	1	469	Chain	ID=PRO_0000089523;Note=Uncharacterized protein C6orf118
C6orf118	Q5T5N4	292	312	301	301	Natural variant	ID=VAR_050809;Note=T->M;Dbxref=dbSNP:rs540751
CETP	P11597	250	310	18	493	Chain	ID=PRO_0000017155;Note=Cholesteryl ester transfer protein
CETP	P11597	250	310	257	257	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
CETP	P11597	250	310	251	310	Alternative sequence	ID=VSP_023645;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
CETP	P11597	250	310	299	299	Natural variant	ID=VAR_033100;Note=In HALP1%3B reduced secretion into plasma. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12091484;Dbxref=dbSNP:rs142459781,PMID:12091484
CETP	P11597	250	310	282	282	Mutagenesis	Note=Not secreted. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17237796;Dbxref=PMID:17237796
CETP	P11597	250	310	287	287	Mutagenesis	Note=Not secreted. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17237796;Dbxref=PMID:17237796
CETP	P11597	250	310	309	309	Mutagenesis	Note=Not secreted. F->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17237796;Dbxref=PMID:17237796
CETP	P11597	250	310	252	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBD
CETP	P11597	250	310	269	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBD
CETP	P11597	250	310	274	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBD
CETP	P11597	250	310	284	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBD
CETP	P11597	250	310	300	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBD
CETP	P11597	250	310	306	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OBD
CTSH	P09668	269	310	116	335	Chain	ID=PRO_0000026209;Note=Cathepsin H
CTSH	P09668	210	233	116	335	Chain	ID=PRO_0000026209;Note=Cathepsin H
CTSH	P09668	135	164	116	335	Chain	ID=PRO_0000026209;Note=Cathepsin H
CTSH	P09668	269	310	116	292	Chain	ID=PRO_0000026210;Note=Cathepsin H heavy chain
CTSH	P09668	210	233	116	292	Chain	ID=PRO_0000026210;Note=Cathepsin H heavy chain
CTSH	P09668	135	164	116	292	Chain	ID=PRO_0000026210;Note=Cathepsin H heavy chain
CTSH	P09668	269	310	293	335	Chain	ID=PRO_0000026211;Note=Cathepsin H light chain
CTSH	P09668	135	164	141	141	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	269	310	281	281	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	269	310	301	301	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	210	233	230	230	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:3342889;Dbxref=PMID:19159218,PMID:3342889
CTSH	P09668	269	310	102	327	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	210	233	102	327	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	135	164	102	327	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	135	164	138	181	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	210	233	172	214	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	269	310	272	322	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSH	P09668	269	310	306	306	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSH	P09668	269	310	306	306	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSZ	Q9UBR2	102	162	62	303	Chain	ID=PRO_0000026286;Note=Cathepsin Z
CTSZ	Q9UBR2	102	162	89	132	Disulfide bond	.
CTSZ	Q9UBR2	102	162	126	164	Disulfide bond	.
CTSZ	Q9UBR2	102	162	154	170	Disulfide bond	.
CTSZ	Q9UBR2	102	162	129	129	Natural variant	ID=VAR_010255;Note=Requires 2 nucleotide substitutions. A->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9738465;Dbxref=PMID:9738465
CTSZ	Q9UBR2	102	162	150	150	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSZ	Q9UBR2	102	162	92	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSZ	Q9UBR2	102	162	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSZ	Q9UBR2	102	162	120	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSZ	Q9UBR2	102	162	127	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSZ	Q9UBR2	102	162	133	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSZ	Q9UBR2	102	162	137	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSZ	Q9UBR2	102	162	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF7
CTSZ	Q9UBR2	102	162	152	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DEU
CTSK	P43235	40	81	16	114	Propeptide	ID=PRO_0000026295;Note=Activation peptide
CTSK	P43235	133	206	115	329	Chain	ID=PRO_0000026296;Note=Cathepsin K
CTSK	P43235	133	206	139	139	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSK	P43235	133	206	136	177	Disulfide bond	.
CTSK	P43235	133	206	170	210	Disulfide bond	.
CTSK	P43235	40	81	79	79	Natural variant	ID=VAR_015738;Note=In PKND. G->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10491211,ECO:0000269|PubMed:10878663;Dbxref=dbSNP:rs74315305,PMID:10491211,PMID:10878663
CTSK	P43235	133	206	146	146	Natural variant	ID=VAR_006725;Note=In PKND. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8703060;Dbxref=dbSNP:rs74315302,PMID:8703060
CTSK	P43235	40	81	46	46	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSK	P43235	40	81	40	66	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY8
CTSK	P43235	40	81	70	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY8
CTSK	P43235	40	81	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BY8
CTSK	P43235	133	206	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KX1
CTSK	P43235	133	206	139	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6H
CTSK	P43235	133	206	164	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6H
CTSK	P43235	133	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6H
CTSK	P43235	133	206	182	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6H
CTSK	P43235	133	206	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6H
CTSK	P43235	133	206	198	200	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X6H
CAPZA2	P47755	195	219	2	286	Chain	ID=PRO_0000208627;Note=F-actin-capping protein subunit alpha-2
CAPZA2	P47755	219	240	2	286	Chain	ID=PRO_0000208627;Note=F-actin-capping protein subunit alpha-2
CAPZA2	P47755	195	219	173	286	Alternative sequence	ID=VSP_053872;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CAPZA2	P47755	219	240	173	286	Alternative sequence	ID=VSP_053872;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CTSV	O60911	83	132	18	113	Propeptide	ID=PRO_0000026277;Note=Activation peptide
CTSV	O60911	83	132	18	113	Propeptide	ID=PRO_0000026277;Note=Activation peptide
CTSV	O60911	132	207	114	334	Chain	ID=PRO_0000026278;Note=Cathepsin L2
CTSV	O60911	83	132	114	334	Chain	ID=PRO_0000026278;Note=Cathepsin L2
CTSV	O60911	132	207	114	334	Chain	ID=PRO_0000026278;Note=Cathepsin L2
CTSV	O60911	83	132	114	334	Chain	ID=PRO_0000026278;Note=Cathepsin L2
CTSV	O60911	132	207	138	138	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11027133;Dbxref=PMID:11027133
CTSV	O60911	132	207	138	138	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11027133;Dbxref=PMID:11027133
CTSV	O60911	132	207	135	178	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FH0,ECO:0000244|PDB:3H6S,ECO:0000244|PDB:3KFQ,ECO:0000269|PubMed:11027133;Dbxref=PMID:11027133
CTSV	O60911	132	207	135	178	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FH0,ECO:0000244|PDB:3H6S,ECO:0000244|PDB:3KFQ,ECO:0000269|PubMed:11027133;Dbxref=PMID:11027133
CTSV	O60911	132	207	169	211	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FH0,ECO:0000244|PDB:3H6S,ECO:0000244|PDB:3KFQ,ECO:0000269|PubMed:11027133;Dbxref=PMID:11027133
CTSV	O60911	132	207	169	211	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1FH0,ECO:0000244|PDB:3H6S,ECO:0000244|PDB:3KFQ,ECO:0000269|PubMed:11027133;Dbxref=PMID:11027133
CTSV	O60911	83	132	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	83	132	120	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	138	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	138	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	163	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	163	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	171	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	183	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	196	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
CTSV	O60911	132	207	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FH0
C2orf42	Q9NWW7	311	346	1	574	Chain	ID=PRO_0000300121;Note=Uncharacterized protein C2orf42
C2orf42	Q9NWW7	311	346	1	574	Chain	ID=PRO_0000300121;Note=Uncharacterized protein C2orf42
C2orf42	Q9NWW7	311	346	314	314	Natural variant	ID=VAR_050712;Note=Q->P;Dbxref=dbSNP:rs3213941
C2orf42	Q9NWW7	311	346	314	314	Natural variant	ID=VAR_050712;Note=Q->P;Dbxref=dbSNP:rs3213941
CAPZA1	P52907	73	142	2	286	Chain	ID=PRO_0000208624;Note=F-actin-capping protein subunit alpha-1
CAPZA1	P52907	195	219	2	286	Chain	ID=PRO_0000208624;Note=F-actin-capping protein subunit alpha-1
CAPZA1	P52907	73	142	97	97	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CAPZA1	P52907	195	219	219	219	Natural variant	ID=VAR_073834;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24951542;Dbxref=dbSNP:rs555597264,PMID:24951542
CPA1	P15085	161	195	111	419	Chain	ID=PRO_0000004346;Note=Carboxypeptidase A1
CPA1	P15085	161	195	179	182	Region	Note=Substrate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2V77,ECO:0000269|PubMed:18566513;Dbxref=PMID:18566513
CPA1	P15085	161	195	179	179	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2V77,ECO:0000269|PubMed:18566513;Dbxref=PMID:18566513
CPA1	P15085	161	195	182	182	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2V77,ECO:0000269|PubMed:18566513;Dbxref=PMID:18566513
CPA1	P15085	161	195	156	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FJU
CPA1	P15085	161	195	164	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UEE
CPA1	P15085	161	195	171	176	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FJU
CPA1	P15085	161	195	183	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FJU
CREBBP	Q92793	1520	1576	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	1427	1464	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	1378	1426	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	1260	1278	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	1233	1259	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	821	960	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	761	821	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	704	719	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	443	524	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	405	443	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	266	325	2	2442	Chain	ID=PRO_0000211190;Note=CREB-binding protein
CREBBP	Q92793	1520	1576	1323	1700	Domain	Note=CBP/p300-type HAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01065
CREBBP	Q92793	1427	1464	1323	1700	Domain	Note=CBP/p300-type HAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01065
CREBBP	Q92793	1378	1426	1323	1700	Domain	Note=CBP/p300-type HAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01065
CREBBP	Q92793	405	443	347	433	Zinc finger	Note=TAZ-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00203
CREBBP	Q92793	405	443	227	410	Region	Note=Interaction with SRCAP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10347196;Dbxref=PMID:10347196
CREBBP	Q92793	266	325	227	410	Region	Note=Interaction with SRCAP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10347196;Dbxref=PMID:10347196
CREBBP	Q92793	1427	1464	1433	1435	Region	Note=Interaction with histone;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q09472
CREBBP	Q92793	1427	1464	1434	1436	Region	Note=Acetyl-CoA binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q09472
CREBBP	Q92793	1427	1464	1446	1447	Region	Note=Acetyl-CoA binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q09472
CREBBP	Q92793	1520	1576	1460	1891	Region	Note=Interaction with TRERF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349124;Dbxref=PMID:11349124
CREBBP	Q92793	1427	1464	1460	1891	Region	Note=Interaction with TRERF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11349124;Dbxref=PMID:11349124
CREBBP	Q92793	1427	1464	1199	1487	Compositional bias	Note=Cys/His-rich
CREBBP	Q92793	1378	1426	1199	1487	Compositional bias	Note=Cys/His-rich
CREBBP	Q92793	1260	1278	1199	1487	Compositional bias	Note=Cys/His-rich
CREBBP	Q92793	1233	1259	1199	1487	Compositional bias	Note=Cys/His-rich
CREBBP	Q92793	1520	1576	1555	1562	Compositional bias	Note=Poly-Glu
CREBBP	Q92793	405	443	409	409	Metal binding	Note=Zinc 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREBBP	Q92793	405	443	418	418	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREBBP	Q92793	405	443	422	422	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREBBP	Q92793	405	443	427	427	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREBBP	Q92793	405	443	430	430	Metal binding	Note=Zinc 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
CREBBP	Q92793	266	325	266	267	Site	Note=Breakpoint for translocation to form KAT6A-CREBBP
CREBBP	Q92793	1378	1426	1382	1382	Modified residue	Note=Phosphoserine%3B by IKKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17434128;Dbxref=PMID:17434128
CREBBP	Q92793	1378	1426	1386	1386	Modified residue	Note=Phosphoserine%3B by IKKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17434128;Dbxref=PMID:17434128
CREBBP	Q92793	443	524	406	444	Alternative sequence	ID=VSP_045700;Note=In isoform 2. VAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CREBBP	Q92793	405	443	406	444	Alternative sequence	ID=VSP_045700;Note=In isoform 2. VAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CREBBP	Q92793	443	524	503	503	Natural variant	ID=VAR_072912;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25388907;Dbxref=dbSNP:rs748447855,PMID:25388907
CREBBP	Q92793	761	821	789	789	Natural variant	ID=VAR_072916;Note=In RSTS1. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25388907;Dbxref=dbSNP:rs746728741,PMID:25388907
CREBBP	Q92793	821	960	910	910	Natural variant	ID=VAR_072917;Note=In RSTS1%3B incomplete. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20684013;Dbxref=dbSNP:rs143247685,PMID:20684013
CREBBP	Q92793	1260	1278	1278	1278	Natural variant	ID=VAR_072918;Note=In RSTS1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25388907;Dbxref=PMID:25388907
CREBBP	Q92793	1260	1278	1278	1278	Natural variant	ID=VAR_035080;Note=In RSTS1%3B abolishes acetyltransferase activity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12566391,ECO:0000269|PubMed:15706485;Dbxref=dbSNP:rs267606752,PMID:12566391,PMID:15706485
CREBBP	Q92793	1378	1426	1378	1378	Natural variant	ID=VAR_015578;Note=In RSTS1%3B abolishes acetyltransferase activity and the ability of transactivate CREB. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11331617,ECO:0000269|PubMed:25388907;Dbxref=dbSNP:rs121434626,PMID:11331617,PMID:25388907
CREBBP	Q92793	1378	1426	1406	1406	Natural variant	ID=VAR_072919;Note=In RSTS1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25388907;Dbxref=PMID:25388907
CREBBP	Q92793	1378	1426	1414	1414	Natural variant	ID=VAR_027953;Note=V->I;Dbxref=dbSNP:rs130015
CREBBP	Q92793	1378	1426	1415	1415	Natural variant	ID=VAR_072920;Note=In RSTS1. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25388907;Dbxref=PMID:25388907
CREBBP	Q92793	1427	1464	1447	1447	Natural variant	ID=VAR_035081;Note=In RSTS1. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15706485;Dbxref=PMID:15706485
CREBBP	Q92793	1427	1464	1450	1450	Natural variant	ID=VAR_035082;Note=In RSTS1. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15706485;Dbxref=PMID:15706485
CREBBP	Q92793	1520	1576	1543	1543	Natural variant	ID=VAR_072924;Note=In RSTS1. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25388907;Dbxref=PMID:25388907
CREBBP	Q92793	1233	1259	1231	1233	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I8G
CREBBP	Q92793	1233	1259	1234	1237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I8G
CREBBP	Q92793	1233	1259	1238	1240	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I8G
CREBBP	Q92793	1260	1278	1266	1272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I8G
CBS	P35520	408	452	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	382	407	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	408	452	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	382	407	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	408	452	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	382	407	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	408	452	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	382	407	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	517	531	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	408	452	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	382	407	1	551	Chain	ID=PRO_0000167133;Note=Cystathionine beta-synthase
CBS	P35520	408	452	418	476	Domain	Note=CBS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CBS	P35520	408	452	418	476	Domain	Note=CBS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CBS	P35520	408	452	418	476	Domain	Note=CBS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CBS	P35520	408	452	418	476	Domain	Note=CBS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CBS	P35520	408	452	418	476	Domain	Note=CBS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703
CBS	P35520	517	531	518	518	Alternative sequence	ID=VSP_001217;Note=In isoform 2. Y->SQDQAWAGVVGGPAD;Ontology_term=ECO:0000305;evidence=ECO:0000305
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_002191;Note=In CBSD%3B severe form. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8990018;Dbxref=dbSNP:rs121964967,PMID:8990018
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_002191;Note=In CBSD%3B severe form. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8990018;Dbxref=dbSNP:rs121964967,PMID:8990018
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_002191;Note=In CBSD%3B severe form. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8990018;Dbxref=dbSNP:rs121964967,PMID:8990018
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_002191;Note=In CBSD%3B severe form. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8990018;Dbxref=dbSNP:rs121964967,PMID:8990018
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_002191;Note=In CBSD%3B severe form. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8990018;Dbxref=dbSNP:rs121964967,PMID:8990018
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_008086;Note=In CBSD%3B moderate form. K->N
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_008086;Note=In CBSD%3B moderate form. K->N
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_008086;Note=In CBSD%3B moderate form. K->N
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_008086;Note=In CBSD%3B moderate form. K->N
CBS	P35520	382	407	384	384	Natural variant	ID=VAR_008086;Note=In CBSD%3B moderate form. K->N
CBS	P35520	382	407	391	391	Natural variant	ID=VAR_008087;Note=In CBSD. M->I
CBS	P35520	382	407	391	391	Natural variant	ID=VAR_008087;Note=In CBSD. M->I
CBS	P35520	382	407	391	391	Natural variant	ID=VAR_008087;Note=In CBSD. M->I
CBS	P35520	382	407	391	391	Natural variant	ID=VAR_008087;Note=In CBSD. M->I
CBS	P35520	382	407	391	391	Natural variant	ID=VAR_008087;Note=In CBSD. M->I
CBS	P35520	408	452	422	422	Natural variant	ID=VAR_021802;Note=In CBSD%3B changed cystathionine beta-synthase activity%3B impaired stimulation by AdoMet%3B does not affect homotetramer formation. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=dbSNP:rs28934892,PMID:12007221,PMID:20506325
CBS	P35520	408	452	422	422	Natural variant	ID=VAR_021802;Note=In CBSD%3B changed cystathionine beta-synthase activity%3B impaired stimulation by AdoMet%3B does not affect homotetramer formation. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=dbSNP:rs28934892,PMID:12007221,PMID:20506325
CBS	P35520	408	452	422	422	Natural variant	ID=VAR_021802;Note=In CBSD%3B changed cystathionine beta-synthase activity%3B impaired stimulation by AdoMet%3B does not affect homotetramer formation. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=dbSNP:rs28934892,PMID:12007221,PMID:20506325
CBS	P35520	408	452	422	422	Natural variant	ID=VAR_021802;Note=In CBSD%3B changed cystathionine beta-synthase activity%3B impaired stimulation by AdoMet%3B does not affect homotetramer formation. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=dbSNP:rs28934892,PMID:12007221,PMID:20506325
CBS	P35520	408	452	422	422	Natural variant	ID=VAR_021802;Note=In CBSD%3B changed cystathionine beta-synthase activity%3B impaired stimulation by AdoMet%3B does not affect homotetramer formation. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=dbSNP:rs28934892,PMID:12007221,PMID:20506325
CBS	P35520	408	452	427	427	Natural variant	ID=VAR_074592;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645;Dbxref=dbSNP:rs863223434,PMID:23974653,PMID:25044645
CBS	P35520	408	452	427	427	Natural variant	ID=VAR_074592;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645;Dbxref=dbSNP:rs863223434,PMID:23974653,PMID:25044645
CBS	P35520	408	452	427	427	Natural variant	ID=VAR_074592;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645;Dbxref=dbSNP:rs863223434,PMID:23974653,PMID:25044645
CBS	P35520	408	452	427	427	Natural variant	ID=VAR_074592;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645;Dbxref=dbSNP:rs863223434,PMID:23974653,PMID:25044645
CBS	P35520	408	452	427	427	Natural variant	ID=VAR_074592;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645;Dbxref=dbSNP:rs863223434,PMID:23974653,PMID:25044645
CBS	P35520	408	452	434	434	Natural variant	ID=VAR_008088;Note=In CBSD. T->N
CBS	P35520	408	452	434	434	Natural variant	ID=VAR_008088;Note=In CBSD. T->N
CBS	P35520	408	452	434	434	Natural variant	ID=VAR_008088;Note=In CBSD. T->N
CBS	P35520	408	452	434	434	Natural variant	ID=VAR_008088;Note=In CBSD. T->N
CBS	P35520	408	452	434	434	Natural variant	ID=VAR_008088;Note=In CBSD. T->N
CBS	P35520	408	452	435	435	Natural variant	ID=VAR_008089;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B impaired stimulation by AdoMet and AdoHcy%3B does not affect homotetramer formation. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=PMID:12007221,PMID:20506325
CBS	P35520	408	452	435	435	Natural variant	ID=VAR_008089;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B impaired stimulation by AdoMet and AdoHcy%3B does not affect homotetramer formation. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=PMID:12007221,PMID:20506325
CBS	P35520	408	452	435	435	Natural variant	ID=VAR_008089;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B impaired stimulation by AdoMet and AdoHcy%3B does not affect homotetramer formation. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=PMID:12007221,PMID:20506325
CBS	P35520	408	452	435	435	Natural variant	ID=VAR_008089;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B impaired stimulation by AdoMet and AdoHcy%3B does not affect homotetramer formation. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=PMID:12007221,PMID:20506325
CBS	P35520	408	452	435	435	Natural variant	ID=VAR_008089;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B impaired stimulation by AdoMet and AdoHcy%3B does not affect homotetramer formation. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325;Dbxref=PMID:12007221,PMID:20506325
CBS	P35520	408	452	439	439	Natural variant	ID=VAR_008090;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B increased homotetramer formation. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10462600,ECO:0000269|PubMed:12124992,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:9156316;Dbxref=dbSNP:rs756467921,PMID:10462600,PMID:12124992,PMID:20506325,PMID:9156316
CBS	P35520	408	452	439	439	Natural variant	ID=VAR_008090;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B increased homotetramer formation. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10462600,ECO:0000269|PubMed:12124992,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:9156316;Dbxref=dbSNP:rs756467921,PMID:10462600,PMID:12124992,PMID:20506325,PMID:9156316
CBS	P35520	408	452	439	439	Natural variant	ID=VAR_008090;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B increased homotetramer formation. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10462600,ECO:0000269|PubMed:12124992,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:9156316;Dbxref=dbSNP:rs756467921,PMID:10462600,PMID:12124992,PMID:20506325,PMID:9156316
CBS	P35520	408	452	439	439	Natural variant	ID=VAR_008090;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B increased homotetramer formation. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10462600,ECO:0000269|PubMed:12124992,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:9156316;Dbxref=dbSNP:rs756467921,PMID:10462600,PMID:12124992,PMID:20506325,PMID:9156316
CBS	P35520	408	452	439	439	Natural variant	ID=VAR_008090;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B increased homotetramer formation. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10462600,ECO:0000269|PubMed:12124992,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:9156316;Dbxref=dbSNP:rs756467921,PMID:10462600,PMID:12124992,PMID:20506325,PMID:9156316
CBS	P35520	408	452	444	444	Natural variant	ID=VAR_002192;Note=In CBSD%3B decreased expression%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet%3B increased homotetramer formation. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645,ECO:0000269|PubMed:8755636;Dbxref=dbSNP:rs28934891,PMID:12007221,PMID:20506325,PMID:23974653,PMID:25044645,PMID:8755636
CBS	P35520	408	452	444	444	Natural variant	ID=VAR_002192;Note=In CBSD%3B decreased expression%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet%3B increased homotetramer formation. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645,ECO:0000269|PubMed:8755636;Dbxref=dbSNP:rs28934891,PMID:12007221,PMID:20506325,PMID:23974653,PMID:25044645,PMID:8755636
CBS	P35520	408	452	444	444	Natural variant	ID=VAR_002192;Note=In CBSD%3B decreased expression%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet%3B increased homotetramer formation. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645,ECO:0000269|PubMed:8755636;Dbxref=dbSNP:rs28934891,PMID:12007221,PMID:20506325,PMID:23974653,PMID:25044645,PMID:8755636
CBS	P35520	408	452	444	444	Natural variant	ID=VAR_002192;Note=In CBSD%3B decreased expression%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet%3B increased homotetramer formation. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645,ECO:0000269|PubMed:8755636;Dbxref=dbSNP:rs28934891,PMID:12007221,PMID:20506325,PMID:23974653,PMID:25044645,PMID:8755636
CBS	P35520	408	452	444	444	Natural variant	ID=VAR_002192;Note=In CBSD%3B decreased expression%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet%3B increased homotetramer formation. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12007221,ECO:0000269|PubMed:20506325,ECO:0000269|PubMed:23974653,ECO:0000269|PubMed:25044645,ECO:0000269|PubMed:8755636;Dbxref=dbSNP:rs28934891,PMID:12007221,PMID:20506325,PMID:23974653,PMID:25044645,PMID:8755636
CBS	P35520	408	452	446	446	Natural variant	ID=VAR_066103;Note=In CBSD. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21520339;Dbxref=PMID:21520339
CBS	P35520	408	452	446	446	Natural variant	ID=VAR_066103;Note=In CBSD. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21520339;Dbxref=PMID:21520339
CBS	P35520	408	452	446	446	Natural variant	ID=VAR_066103;Note=In CBSD. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21520339;Dbxref=PMID:21520339
CBS	P35520	408	452	446	446	Natural variant	ID=VAR_066103;Note=In CBSD. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21520339;Dbxref=PMID:21520339
CBS	P35520	408	452	446	446	Natural variant	ID=VAR_066103;Note=In CBSD. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21520339;Dbxref=PMID:21520339
CBS	P35520	408	452	449	449	Natural variant	ID=VAR_074593;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25044645;Dbxref=PMID:25044645
CBS	P35520	408	452	449	449	Natural variant	ID=VAR_074593;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25044645;Dbxref=PMID:25044645
CBS	P35520	408	452	449	449	Natural variant	ID=VAR_074593;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25044645;Dbxref=PMID:25044645
CBS	P35520	408	452	449	449	Natural variant	ID=VAR_074593;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25044645;Dbxref=PMID:25044645
CBS	P35520	408	452	449	449	Natural variant	ID=VAR_074593;Note=In CBSD%3B no effect on cystathionine beta-synthase activity%3B altered stimulation by AdoMet. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25044645;Dbxref=PMID:25044645
CBS	P35520	517	531	526	526	Natural variant	ID=VAR_046937;Note=In CBSD%3B has significantly decreased levels of enzyme activity. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14635102;Dbxref=PMID:14635102
CBS	P35520	382	407	382	386	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	382	386	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	382	386	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	382	386	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	382	386	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	388	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	388	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	388	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	388	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	388	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	399	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	399	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	399	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	399	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	382	407	399	404	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4COO
CBS	P35520	408	452	408	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	408	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	408	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	408	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	408	411	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	414	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	414	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	414	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	414	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	414	417	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	431	441	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	431	441	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	431	441	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	431	441	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	431	441	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	444	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	444	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	444	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	444	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	408	452	444	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CBS	P35520	517	531	526	534	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UUU
CCDC134	Q9H6E4	164	188	23	229	Chain	ID=PRO_0000254109;Note=Coiled-coil domain-containing protein 134
CBWD2	Q8IUF1	143	163	1	395	Chain	ID=PRO_0000316813;Note=COBW domain-containing protein 2
CBWD2	Q8IUF1	221	235	1	395	Chain	ID=PRO_0000316813;Note=COBW domain-containing protein 2
CBWD2	Q8IUF1	236	254	1	395	Chain	ID=PRO_0000316813;Note=COBW domain-containing protein 2
CBWD2	Q8IUF1	295	317	1	395	Chain	ID=PRO_0000316813;Note=COBW domain-containing protein 2
CBWD2	Q8IUF1	295	317	274	377	Domain	Note=CobW C-terminal
CBWD2	Q8IUF1	236	254	242	242	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC138	Q96M89	192	245	1	665	Chain	ID=PRO_0000288454;Note=Coiled-coil domain-containing protein 138
CCDC138	Q96M89	347	402	1	665	Chain	ID=PRO_0000288454;Note=Coiled-coil domain-containing protein 138
CCDC138	Q96M89	402	441	1	665	Chain	ID=PRO_0000288454;Note=Coiled-coil domain-containing protein 138
CCDC138	Q96M89	505	564	1	665	Chain	ID=PRO_0000288454;Note=Coiled-coil domain-containing protein 138
CCDC138	Q96M89	192	245	198	323	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC142	Q17RM4	340	369	1	750	Chain	ID=PRO_0000311260;Note=Coiled-coil domain-containing protein 142
CCDC152	Q4G0S7	186	214	1	254	Chain	ID=PRO_0000320586;Note=Coiled-coil domain-containing protein 152
CCDC152	Q4G0S7	186	214	61	246	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC62	Q6P9F0	132	166	1	684	Chain	ID=PRO_0000240247;Note=Coiled-coil domain-containing protein 62
CCDC62	Q6P9F0	132	166	11	160	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC62	Q6P9F0	132	166	1	239	Alternative sequence	ID=VSP_019327;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC62	Q6P9F0	132	166	141	141	Natural variant	ID=VAR_061585;Note=T->M;Dbxref=dbSNP:rs58131754
DBF4	Q9UBU7	73	133	1	674	Chain	ID=PRO_0000234061;Note=Protein DBF4 homolog A
DBF4	Q9UBU7	133	150	1	674	Chain	ID=PRO_0000234061;Note=Protein DBF4 homolog A
DBF4	Q9UBU7	73	133	40	128	Domain	Note=BRCT 1
DBF4	Q9UBU7	73	133	112	112	Natural variant	ID=VAR_052970;Note=Y->N;Dbxref=dbSNP:rs1476703
DBF4B	Q8NFT6	6	27	1	615	Chain	ID=PRO_0000317553;Note=Protein DBF4 homolog B
DBF4B	Q8NFT6	75	139	1	615	Chain	ID=PRO_0000317553;Note=Protein DBF4 homolog B
DBF4B	Q8NFT6	238	276	1	615	Chain	ID=PRO_0000317553;Note=Protein DBF4 homolog B
DBF4B	Q8NFT6	75	139	43	133	Domain	Note=BRCT
DBF4B	Q8NFT6	6	27	1	186	Alternative sequence	ID=VSP_031014;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DBF4B	Q8NFT6	75	139	1	186	Alternative sequence	ID=VSP_031014;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DBF4B	Q8NFT6	238	276	171	615	Alternative sequence	ID=VSP_031016;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCSER1	Q9C0I3	644	670	1	900	Chain	ID=PRO_0000349292;Note=Serine-rich coiled-coil domain-containing protein 1
CCSER1	Q9C0I3	670	698	1	900	Chain	ID=PRO_0000349292;Note=Serine-rich coiled-coil domain-containing protein 1
CCSER1	Q9C0I3	698	724	1	900	Chain	ID=PRO_0000349292;Note=Serine-rich coiled-coil domain-containing protein 1
CCSER1	Q9C0I3	670	698	673	707	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCSER1	Q9C0I3	698	724	673	707	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCSER1	Q9C0I3	670	698	671	677	Alternative sequence	ID=VSP_035318;Note=In isoform 2. DIMKDEC->TTYPREF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCSER1	Q9C0I3	670	698	678	900	Alternative sequence	ID=VSP_035319;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCSER1	Q9C0I3	698	724	678	900	Alternative sequence	ID=VSP_035319;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CPB2	Q96IY4	197	234	115	423	Chain	ID=PRO_0000004378;Note=Carboxypeptidase B2
CPB2	Q96IY4	162	197	115	423	Chain	ID=PRO_0000004378;Note=Carboxypeptidase B2
CPB2	Q96IY4	128	162	115	423	Chain	ID=PRO_0000004378;Note=Carboxypeptidase B2
CPB2	Q96IY4	162	197	181	184	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00730
CPB2	Q96IY4	162	197	181	181	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18559974,ECO:0000269|PubMed:20088943;Dbxref=PMID:18559974,PMID:20088943
CPB2	Q96IY4	162	197	184	184	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18559974,ECO:0000269|PubMed:20088943;Dbxref=PMID:18559974,PMID:20088943
CPB2	Q96IY4	162	197	178	191	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18559974,ECO:0000269|PubMed:20088943;Dbxref=PMID:18559974,PMID:20088943
CPB2	Q96IY4	197	234	198	234	Alternative sequence	ID=VSP_013446;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CPB2	Q96IY4	162	197	169	169	Natural variant	ID=VAR_032565;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1939207;Dbxref=dbSNP:rs3742264,PMID:14702039,PMID:1939207
CPB2	Q96IY4	128	162	126	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	128	162	141	143	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	128	162	144	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	162	197	157	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	128	162	157	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	162	197	172	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	197	234	186	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	162	197	186	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	197	234	202	204	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	197	234	206	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	197	234	215	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CPB2	Q96IY4	197	234	225	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4P10
CBLN2	Q8IUK8	119	159	52	224	Chain	ID=PRO_0000003551;Note=Cerebellin-2
CBLN2	Q8IUK8	119	159	52	224	Chain	ID=PRO_0000003551;Note=Cerebellin-2
CBLN2	Q8IUK8	119	159	88	224	Domain	Note=C1q;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00368
CBLN2	Q8IUK8	119	159	88	224	Domain	Note=C1q;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00368
C3orf33	Q6P1S2	38	58	2	294	Chain	ID=PRO_0000254577;Note=Protein C3orf33
C3orf33	Q6P1S2	38	58	40	56	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
C3orf33	Q6P1S2	38	58	1	43	Alternative sequence	ID=VSP_046233;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C3orf33	Q6P1S2	38	58	47	47	Natural variant	ID=VAR_028846;Note=A->T;Dbxref=dbSNP:rs9853408
CBR4	Q8N4T8	133	178	1	237	Chain	ID=PRO_0000319878;Note=Carbonyl reductase family member 4
CBR4	Q8N4T8	133	178	148	148	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
CBR4	Q8N4T8	133	178	135	135	Binding site	Note=Substrate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	148	148	Binding site	Note=NADP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4CQM,ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	152	152	Binding site	Note=NADP;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4CQM,ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	169	169	Site	Note=Important for interaction with acyl carrier protein (ACP);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	135	135	Mutagenesis	Note=Unable to restore growth of an OAR1-deficient yeast mutant. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	148	148	Mutagenesis	Note=Unable to restore growth of an OAR1-deficient yeast mutant. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	152	152	Mutagenesis	Note=Unable to restore growth of an OAR1-deficient yeast mutant. Abolishes NADPH-dependent reductase activity with acetoacetyl-CoA. Strongly reduces NADPH-dependent reductase activity with 9%2C10-phenanthrene quinone. No effect on NADH-dependent reductase activities. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	168	168	Mutagenesis	Note=Strongly reduced ability to restore growth of an OAR1-deficient yeast mutant. Increases NADPH-dependent reductase activity with acetoacetyl-CoA. Reduces NADPH-dependent reductase activity with 9%2C10-phenanthrene quinone. No effect on NADH-dependent reductase activities. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	169	169	Mutagenesis	Note=Unable to restore growth of an OAR1-deficient yeast mutant. Increases NADPH-dependent reductase activity with acetoacetyl-CoA. Reduces NADPH-dependent reductase activity with 9%2C10-phenanthrene quinone. No effect on NADH-dependent reductase activities. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25203508;Dbxref=PMID:25203508
CBR4	Q8N4T8	133	178	128	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQM
CBR4	Q8N4T8	133	178	136	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQM
CBR4	Q8N4T8	133	178	146	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQM
CBR4	Q8N4T8	133	178	167	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQM
CBR4	Q8N4T8	133	178	171	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CQM
CCDC130	P13994	1	19	1	396	Chain	ID=PRO_0000064401;Note=Coiled-coil domain-containing protein 130
CCDC130	P13994	1	19	1	396	Chain	ID=PRO_0000064401;Note=Coiled-coil domain-containing protein 130
CBX7	O95931	38	59	1	251	Chain	ID=PRO_0000080212;Note=Chromobox protein homolog 7
CBX7	O95931	38	59	11	69	Domain	Note=Chromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
CBX7	O95931	38	59	37	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MN3
CBX7	O95931	38	59	41	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MN3
CBX7	O95931	38	59	45	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MN3
CBX7	O95931	38	59	51	60	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MN3
CCDC178	Q5BJE1	796	841	1	867	Chain	ID=PRO_0000223316;Note=Coiled-coil domain-containing protein 178
CCDC178	Q5BJE1	746	796	1	867	Chain	ID=PRO_0000223316;Note=Coiled-coil domain-containing protein 178
CCDC178	Q5BJE1	796	841	1	867	Chain	ID=PRO_0000223316;Note=Coiled-coil domain-containing protein 178
CCDC178	Q5BJE1	746	796	1	867	Chain	ID=PRO_0000223316;Note=Coiled-coil domain-containing protein 178
CCDC178	Q5BJE1	796	841	747	796	Alternative sequence	ID=VSP_017258;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC178	Q5BJE1	746	796	747	796	Alternative sequence	ID=VSP_017258;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC178	Q5BJE1	796	841	747	796	Alternative sequence	ID=VSP_017258;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC178	Q5BJE1	746	796	747	796	Alternative sequence	ID=VSP_017258;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC178	Q5BJE1	746	796	768	768	Sequence conflict	Note=I->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC178	Q5BJE1	746	796	768	768	Sequence conflict	Note=I->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC74A	Q96AQ1	98	181	1	378	Chain	ID=PRO_0000274374;Note=Coiled-coil domain-containing protein 74A
CCDC74A	Q96AQ1	98	181	100	165	Alternative sequence	ID=VSP_022729;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC13	Q8IYE1	532	572	1	715	Chain	ID=PRO_0000089409;Note=Coiled-coil domain-containing protein 13
CCDC13	Q8IYE1	504	531	1	715	Chain	ID=PRO_0000089409;Note=Coiled-coil domain-containing protein 13
CCDC13	Q8IYE1	171	201	1	715	Chain	ID=PRO_0000089409;Note=Coiled-coil domain-containing protein 13
CCDC13	Q8IYE1	171	201	134	458	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC13	Q8IYE1	532	572	554	608	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC13	Q8IYE1	532	572	536	536	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3YV10
CCDC13	Q8IYE1	532	572	547	547	Natural variant	ID=VAR_033664;Note=S->T;Dbxref=dbSNP:rs12495805
CCDC58	Q4VC31	108	128	2	144	Chain	ID=PRO_0000239441;Note=Coiled-coil domain-containing protein 58
CCDC58	Q4VC31	59	108	2	144	Chain	ID=PRO_0000239441;Note=Coiled-coil domain-containing protein 58
CCDC58	Q4VC31	108	128	82	120	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC58	Q4VC31	59	108	82	120	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC58	Q4VC31	59	108	100	100	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CCL20	P78556	64	89	27	96	Chain	ID=PRO_0000005217;Note=C-C motif chemokine 20
CCL20	P78556	64	89	27	93	Chain	ID=PRO_0000041854;Note=CCL20(1-67)
CCL20	P78556	64	89	27	90	Chain	ID=PRO_0000041855;Note=CCL20(1-64)
CCL20	P78556	64	89	28	96	Chain	ID=PRO_0000041856;Note=CCL20(2-70)
CCL20	P78556	64	89	33	74	Disulfide bond	.
CCL20	P78556	64	89	62	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M8A
CCL20	P78556	64	89	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M8A
CCL20	P78556	64	89	80	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M8A
CCNI	Q14094	153	230	1	377	Chain	ID=PRO_0000080476;Note=Cyclin-I
CCNI	Q14094	106	153	1	377	Chain	ID=PRO_0000080476;Note=Cyclin-I
CCNI	Q14094	81	106	1	377	Chain	ID=PRO_0000080476;Note=Cyclin-I
CCNI	Q14094	38	81	1	377	Chain	ID=PRO_0000080476;Note=Cyclin-I
CCNI	Q14094	38	81	1	38	Alternative sequence	ID=VSP_056682;Note=In isoform 2. MKFPGPLENQRLSFLLEKAITREAQMWKVNVRKMPSNQ->MTPRHHCEAYSSAGEEEEEEEEEK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCNI	Q14094	153	230	207	207	Natural variant	ID=VAR_016312;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs4252903
CCNI	Q14094	38	81	58	58	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCNI	Q14094	38	81	75	75	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCNJL	Q8IV13	93	141	1	435	Chain	ID=PRO_0000309319;Note=Cyclin-J-like protein
CCNJL	Q8IV13	93	141	14	191	Domain	Note=Cyclin N-terminal
CCNJL	Q8IV13	93	141	94	121	Alternative sequence	ID=VSP_029131;Note=In isoform 2. NGVSLLSPRLKCSGMISAHCNLHLPGSS->SRNKGSGSPVPTRSAQQCRQTWARGSPW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCNJL	Q8IV13	93	141	122	435	Alternative sequence	ID=VSP_029132;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
C4orf50	Q6ZRC1	1	56	1	276	Chain	ID=PRO_0000329449;Note=Uncharacterized protein C4orf50
C4orf50	Q6ZRC1	1	56	37	72	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	1	18	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8673704;Dbxref=PMID:8673704
CD226	Q15762	15	127	1	18	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8673704;Dbxref=PMID:8673704
CD226	Q15762	15	127	19	336	Chain	ID=PRO_0000014665;Note=CD226 antigen
CD226	Q15762	15	127	19	336	Chain	ID=PRO_0000014665;Note=CD226 antigen
CD226	Q15762	15	127	19	254	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	19	254	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	19	126	Domain	Note=Ig-like C2-type 1
CD226	Q15762	15	127	19	126	Domain	Note=Ig-like C2-type 1
CD226	Q15762	15	127	32	32	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	32	32	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	90	90	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	90	90	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	97	97	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	97	97	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD226	Q15762	15	127	37	108	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD226	Q15762	15	127	37	108	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD33	P20138	12	139	1	17	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD33	P20138	12	139	18	364	Chain	ID=PRO_0000014878;Note=Myeloid cell surface antigen CD33
CD33	P20138	232	248	18	364	Chain	ID=PRO_0000014878;Note=Myeloid cell surface antigen CD33
CD33	P20138	12	139	18	259	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD33	P20138	232	248	18	259	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD33	P20138	12	139	19	135	Domain	Note=Ig-like V-type
CD33	P20138	12	139	119	119	Binding site	Note=Sialic acid;Ontology_term=ECO:0000250;evidence=ECO:0000250
CD33	P20138	12	139	100	100	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD33	P20138	12	139	113	113	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD33	P20138	12	139	36	169	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD33	P20138	12	139	41	101	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD33	P20138	12	139	13	139	Alternative sequence	ID=VSP_046172;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16380601;Dbxref=PMID:16380601
CD33	P20138	12	139	14	14	Natural variant	ID=VAR_049904;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs12459419,PMID:14702039
CD33	P20138	12	139	22	22	Natural variant	ID=VAR_049905;Note=W->R;Dbxref=dbSNP:rs35814802
CD33	P20138	12	139	69	69	Natural variant	ID=VAR_028260;Note=R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:3139766;Dbxref=dbSNP:rs2455069,PMID:15489334,PMID:3139766
CD33	P20138	12	139	128	128	Natural variant	ID=VAR_049906;Note=S->N;Dbxref=dbSNP:rs34919259
CD33	P20138	232	248	242	242	Natural variant	ID=VAR_028262;Note=I->L;Dbxref=dbSNP:rs988337
CD33	P20138	232	248	243	243	Natural variant	ID=VAR_028263;Note=F->L;Dbxref=dbSNP:rs11882250
CD33	P20138	12	139	22	25	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	27	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	41	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	49	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	56	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	65	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	84	89	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	90	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	110	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	114	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	125	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD33	P20138	12	139	134	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IHB
CD34	P28906	26	87	1	31	Signal peptide	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1370171,ECO:0000269|PubMed:2462139;Dbxref=PMID:1370171,PMID:2462139
CD34	P28906	26	87	32	385	Chain	ID=PRO_0000020900;Note=Hematopoietic progenitor cell antigen CD34
CD34	P28906	26	87	32	290	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD34	P28906	26	87	36	36	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD34	P28906	26	87	51	51	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD34	P28906	26	87	55	55	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD34	P28906	26	87	85	85	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	1	25	Signal peptide	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:25944712,ECO:0000269|PubMed:9054419;Dbxref=PMID:25944712,PMID:9054419
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	102	Chain	ID=PRO_0000036108;Note=CD59 glycoprotein
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	26	108	Domain	Note=UPAR/Ly6
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:8670172;Dbxref=PMID:18780401,PMID:8670172
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	28	51	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	31	38	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	44	64	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8276756;Dbxref=PMID:8276756
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	29	29	Mutagenesis	Note=No loss of function. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	33	33	Mutagenesis	Note=No loss of function. N->R%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	37	37	Mutagenesis	Note=No loss of function. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	48	48	Mutagenesis	Note=Some loss of function. Some lysis. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	49	49	Mutagenesis	Note=Loss of function. Lysis. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9053451;Dbxref=PMID:9053451
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	27	29	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ERG
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD59	P13987	22	56	50	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8B
CD47	Q08722	15	133	1	18	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	311	322	19	323	Chain	ID=PRO_0000014880;Note=Leukocyte surface antigen CD47
CD47	Q08722	230	261	19	323	Chain	ID=PRO_0000014880;Note=Leukocyte surface antigen CD47
CD47	Q08722	199	230	19	323	Chain	ID=PRO_0000014880;Note=Leukocyte surface antigen CD47
CD47	Q08722	163	199	19	323	Chain	ID=PRO_0000014880;Note=Leukocyte surface antigen CD47
CD47	Q08722	133	163	19	323	Chain	ID=PRO_0000014880;Note=Leukocyte surface antigen CD47
CD47	Q08722	15	133	19	323	Chain	ID=PRO_0000014880;Note=Leukocyte surface antigen CD47
CD47	Q08722	133	163	19	141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	15	133	19	141	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	133	163	142	162	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	163	199	163	176	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	133	163	163	176	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	163	199	177	197	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	199	230	198	207	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	163	199	198	207	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	199	230	208	228	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	230	261	229	235	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	199	230	229	235	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	230	261	236	256	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	230	261	257	268	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	311	322	290	323	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	15	133	19	127	Domain	Note=Ig-like V-type
CD47	Q08722	15	133	19	19	Modified residue	Note=Pyrrolidone carboxylic acid;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657508;Dbxref=PMID:18657508
CD47	Q08722	15	133	89	89	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97829
CD47	Q08722	15	133	23	23	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657508;Dbxref=PMID:18657508
CD47	Q08722	15	133	34	34	Glycosylation	Note=N-linked (GlcNAc...) asparagine
CD47	Q08722	15	133	50	50	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18657508,ECO:0000269|PubMed:19349973;Dbxref=PMID:18657508,PMID:19349973
CD47	Q08722	15	133	73	73	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18657508,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19349973;Dbxref=PMID:18657508,PMID:19159218,PMID:19349973
CD47	Q08722	15	133	111	111	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18657508,ECO:0000269|PubMed:19159218;Dbxref=PMID:18657508,PMID:19159218
CD47	Q08722	199	230	206	206	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD47	Q08722	230	261	33	263	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11454874;Dbxref=PMID:11454874
CD47	Q08722	199	230	33	263	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11454874;Dbxref=PMID:11454874
CD47	Q08722	163	199	33	263	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11454874;Dbxref=PMID:11454874
CD47	Q08722	133	163	33	263	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11454874;Dbxref=PMID:11454874
CD47	Q08722	15	133	33	263	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11454874;Dbxref=PMID:11454874
CD47	Q08722	15	133	41	114	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18657508;Dbxref=PMID:18657508
CD47	Q08722	311	322	293	323	Alternative sequence	ID=VSP_002535;Note=In isoform OA3-293. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD47	Q08722	311	322	306	323	Alternative sequence	ID=VSP_002537;Note=In isoform OA3-305. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7691831,ECO:0000303|Ref.3;Dbxref=PMID:15489334,PMID:7691831
CD47	Q08722	311	322	312	323	Alternative sequence	ID=VSP_002538;Note=In isoform OA3-312. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD47	Q08722	15	133	26	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	35	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	42	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	51	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	54	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	70	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	88	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	98	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	102	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	110	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD47	Q08722	15	133	121	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJS
CD6	P30203	260	361	18	668	Chain	ID=PRO_0000033227;Note=T-cell differentiation antigen CD6
CD6	P30203	383	430	18	668	Chain	ID=PRO_0000033227;Note=T-cell differentiation antigen CD6
CD6	P30203	430	462	18	668	Chain	ID=PRO_0000033227;Note=T-cell differentiation antigen CD6
CD6	P30203	462	503	18	668	Chain	ID=PRO_0000033227;Note=T-cell differentiation antigen CD6
CD6	P30203	612	647	18	668	Chain	ID=PRO_0000033227;Note=T-cell differentiation antigen CD6
CD6	P30203	260	361	18	402	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	383	430	18	402	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	383	430	403	423	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	383	430	424	668	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	430	462	424	668	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	462	503	424	668	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	612	647	424	668	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	260	361	161	260	Domain	Note=SRCR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD6	P30203	260	361	265	361	Domain	Note=SRCR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00196
CD6	P30203	260	361	339	339	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	260	361	345	345	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD6	P30203	260	361	290	350	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5A2E,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	303	360	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5A2E,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	330	340	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:5A2E,ECO:0000255|PROSITE-ProRule:PRU00196,ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	259	359	Alternative sequence	ID=VSP_054245;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17371992;Dbxref=PMID:17371992
CD6	P30203	260	361	261	383	Alternative sequence	ID=VSP_054246;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17371992;Dbxref=PMID:17371992
CD6	P30203	383	430	261	383	Alternative sequence	ID=VSP_054246;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17371992;Dbxref=PMID:17371992
CD6	P30203	430	462	431	462	Alternative sequence	ID=VSP_006221;Note=In isoform CD6B%2C isoform CD6C and isoform CD6D. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD6	P30203	462	503	431	462	Alternative sequence	ID=VSP_006221;Note=In isoform CD6B%2C isoform CD6C and isoform CD6D. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD6	P30203	462	503	463	504	Alternative sequence	ID=VSP_006222;Note=In isoform CD6C and isoform CD6E. VFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYN->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD6	P30203	612	647	613	647	Alternative sequence	ID=VSP_006223;Note=In isoform CD6D and isoform CD6E. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD6	P30203	260	361	271	271	Natural variant	ID=VAR_057203;Note=A->T;Dbxref=dbSNP:rs12360861
CD6	P30203	260	361	351	351	Natural variant	ID=VAR_057204;Note=Adds an additional glycosylation site and impairs interaction with ALCAM. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=dbSNP:rs34974368,PMID:26146185
CD6	P30203	260	361	291	291	Mutagenesis	Note=Strongly reduces interaction with ALCAM. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	293	293	Mutagenesis	Note=Reduces interaction with ALCAM. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	295	295	Mutagenesis	Note=Abolishes interaction with ALCAM. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	298	298	Mutagenesis	Note=Nearly abolishes interaction with ALCAM. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	314	314	Mutagenesis	Note=Reduces interaction with ALCAM. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	327	327	Mutagenesis	Note=Nearly abolishes interaction with ALCAM. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	329	329	Mutagenesis	Note=Reduces interaction with ALCAM. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	346	346	Mutagenesis	Note=Strongly reduces interaction with ALCAM. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	349	349	Mutagenesis	Note=Reduces interaction with ALCAM. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	352	352	Mutagenesis	Note=Reduces interaction with ALCAM. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	260	361	353	353	Mutagenesis	Note=Reduces interaction with ALCAM. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26146185;Dbxref=PMID:26146185
CD6	P30203	462	503	463	468	Sequence conflict	Note=VFMLPI->GPGPAP;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD6	P30203	612	647	613	613	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD6	P30203	260	361	264	272	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	275	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	285	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	296	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	325	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	337	339	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	340	345	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	347	349	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	350	352	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CD6	P30203	260	361	357	363	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A2E
CEP104	O60308	612	681	1	925	Chain	ID=PRO_0000050763;Note=Centrosomal protein of 104 kDa
CEP104	O60308	553	612	1	925	Chain	ID=PRO_0000050763;Note=Centrosomal protein of 104 kDa
CEP104	O60308	373	439	1	925	Chain	ID=PRO_0000050763;Note=Centrosomal protein of 104 kDa
CEP104	O60308	245	297	1	925	Chain	ID=PRO_0000050763;Note=Centrosomal protein of 104 kDa
CEP104	O60308	38	95	1	925	Chain	ID=PRO_0000050763;Note=Centrosomal protein of 104 kDa
CEP104	O60308	553	612	529	567	Repeat	Note=HEAT 1
CEP104	O60308	612	681	604	640	Repeat	Note=HEAT 2
CEP104	O60308	553	612	604	640	Repeat	Note=HEAT 2
CEP104	O60308	245	297	209	289	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP104	O60308	612	681	677	725	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP104	O60308	612	681	245	925	Alternative sequence	ID=VSP_014365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	553	612	245	925	Alternative sequence	ID=VSP_014365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	373	439	245	925	Alternative sequence	ID=VSP_014365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	245	297	245	925	Alternative sequence	ID=VSP_014365;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	553	612	554	554	Alternative sequence	ID=VSP_014366;Note=In isoform 3. E->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	612	681	555	925	Alternative sequence	ID=VSP_014367;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	553	612	555	925	Alternative sequence	ID=VSP_014367;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP104	O60308	373	439	414	414	Natural variant	ID=VAR_034036;Note=L->I;Dbxref=dbSNP:rs2275824
CEP104	O60308	38	95	51	51	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP104	O60308	245	297	266	266	Sequence conflict	Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP104	O60308	373	439	383	383	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP104	O60308	373	439	422	427	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	373	439	429	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	373	439	437	444	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	542	557	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	559	562	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	563	565	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	566	571	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	581	598	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	600	604	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	612	681	607	617	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	553	612	607	617	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	612	681	623	640	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	612	681	641	647	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	612	681	655	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP104	O60308	612	681	659	671	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LPH
CEP120	Q8N960	786	827	1	986	Chain	ID=PRO_0000348262;Note=Centrosomal protein of 120 kDa
CEP120	Q8N960	204	270	1	986	Chain	ID=PRO_0000348262;Note=Centrosomal protein of 120 kDa
CEP120	Q8N960	786	827	1	986	Chain	ID=PRO_0000348262;Note=Centrosomal protein of 120 kDa
CEP120	Q8N960	204	270	1	986	Chain	ID=PRO_0000348262;Note=Centrosomal protein of 120 kDa
CEP120	Q8N960	786	827	669	925	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP120	Q8N960	786	827	669	925	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CEP120	Q8N960	786	827	381	986	Alternative sequence	ID=VSP_035125;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP120	Q8N960	786	827	381	986	Alternative sequence	ID=VSP_035125;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CEP120	Q8N960	204	270	212	212	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP120	Q8N960	204	270	212	212	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP120	Q8N960	204	270	246	246	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CEP120	Q8N960	204	270	246	246	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CELF5	Q8N6W0	367	395	1	485	Chain	ID=PRO_0000295227;Note=CUGBP Elav-like family member 5
CELF1	Q92879	396	444	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	297	334	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	254	297	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	103	148	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	103	148	108	188	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF1	Q92879	396	444	401	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF1	Q92879	297	334	287	308	Compositional bias	Note=Ser-rich
CELF1	Q92879	254	297	287	308	Compositional bias	Note=Ser-rich
CELF1	Q92879	297	334	302	302	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P28659
CELF1	Q92879	103	148	109	109	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CELF1	Q92879	103	148	104	104	Alternative sequence	ID=VSP_026788;Note=In isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.6;Dbxref=PMID:14702039
CELF1	Q92879	297	334	297	297	Alternative sequence	ID=VSP_005785;Note=In isoform 3. S->SA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11686919,ECO:0000303|PubMed:15489334;Dbxref=PMID:11686919,PMID:15489334
CELF1	Q92879	254	297	297	297	Alternative sequence	ID=VSP_005785;Note=In isoform 3. S->SA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11686919,ECO:0000303|PubMed:15489334;Dbxref=PMID:11686919,PMID:15489334
CELF1	Q92879	297	334	331	331	Mutagenesis	Note=Does not reduce RNA-binding%3B when associated with L-63 and F-472. Abolishes ARE/EDEN-dependent deadenylation%3B when associated with D-331 and F-472. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12799066;Dbxref=PMID:12799066
CELF1	Q92879	103	148	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	108	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	121	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	134	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	143	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHS
CELF1	Q92879	103	148	147	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	396	444	399	401	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RQC
CELF1	Q92879	396	444	403	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	414	421	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	422	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	428	434	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	436	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	440	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CENPT	Q96BT3	486	520	1	561	Chain	ID=PRO_0000249514;Note=Centromere protein T
CENPT	Q96BT3	287	395	1	561	Chain	ID=PRO_0000249514;Note=Centromere protein T
CENPT	Q96BT3	234	287	1	561	Chain	ID=PRO_0000249514;Note=Centromere protein T
CENPT	Q96BT3	486	520	1	561	Chain	ID=PRO_0000249514;Note=Centromere protein T
CENPT	Q96BT3	287	395	1	561	Chain	ID=PRO_0000249514;Note=Centromere protein T
CENPT	Q96BT3	234	287	1	561	Chain	ID=PRO_0000249514;Note=Centromere protein T
CENPT	Q96BT3	287	395	93	421	Region	Note=Flexible stalk domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CENPT	Q96BT3	234	287	93	421	Region	Note=Flexible stalk domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CENPT	Q96BT3	287	395	93	421	Region	Note=Flexible stalk domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CENPT	Q96BT3	234	287	93	421	Region	Note=Flexible stalk domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CENPT	Q96BT3	287	395	343	343	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CENPT	Q96BT3	287	395	343	343	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CENPT	Q96BT3	287	395	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q561R1
CENPT	Q96BT3	287	395	345	345	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q561R1
CENPT	Q96BT3	287	395	356	356	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q561R1
CENPT	Q96BT3	287	395	356	356	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q561R1
CENPT	Q96BT3	287	395	373	373	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
CENPT	Q96BT3	287	395	373	373	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
CENPT	Q96BT3	287	395	385	385	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
CENPT	Q96BT3	287	395	385	385	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
CENPT	Q96BT3	287	395	386	386	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
CENPT	Q96BT3	287	395	386	386	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
CENPT	Q96BT3	486	520	152	561	Alternative sequence	ID=VSP_020456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	287	395	152	561	Alternative sequence	ID=VSP_020456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	234	287	152	561	Alternative sequence	ID=VSP_020456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	486	520	152	561	Alternative sequence	ID=VSP_020456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	287	395	152	561	Alternative sequence	ID=VSP_020456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	234	287	152	561	Alternative sequence	ID=VSP_020456;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	287	395	289	299	Alternative sequence	ID=VSP_020457;Note=In isoform 2. PGKPAQFLAGE->ECVALVAWSQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	287	395	289	299	Alternative sequence	ID=VSP_020457;Note=In isoform 2. PGKPAQFLAGE->ECVALVAWSQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	486	520	300	561	Alternative sequence	ID=VSP_020458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	287	395	300	561	Alternative sequence	ID=VSP_020458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	486	520	300	561	Alternative sequence	ID=VSP_020458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CENPT	Q96BT3	287	395	300	561	Alternative sequence	ID=VSP_020458;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CABLES2	Q9BTV7	176	201	1	478	Chain	ID=PRO_0000080512;Note=CDK5 and ABL1 enzyme substrate 2
CACNA1B	Q00975	444	514	1	2339	Chain	ID=PRO_0000053921;Note=Voltage-dependent N-type calcium channel subunit alpha-1B
CACNA1B	Q00975	1181	1201	1	2339	Chain	ID=PRO_0000053921;Note=Voltage-dependent N-type calcium channel subunit alpha-1B
CACNA1B	Q00975	444	514	357	482	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1B	Q00975	444	514	483	501	Transmembrane	Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1B	Q00975	444	514	502	516	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1B	Q00975	1181	1201	1170	1185	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1B	Q00975	1181	1201	1186	1205	Transmembrane	Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1B	Q00975	444	514	468	712	Repeat	Note=II
CACNA1B	Q00975	1181	1201	1137	1419	Repeat	Note=III
CACNA1B	Q00975	444	514	451	458	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
CA1	P00915	150	171	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	12	78	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	150	171	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	12	78	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	150	171	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	12	78	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	150	171	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	12	78	2	261	Chain	ID=PRO_0000077409;Note=Carbonic anhydrase 1
CA1	P00915	150	171	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	150	171	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	150	171	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	150	171	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	4	261	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	65	65	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	65	65	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	65	65	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	65	65	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA1	P00915	12	78	65	65	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	65	65	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	65	65	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	65	65	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	68	68	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	68	68	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	68	68	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	68	68	Metal binding	Note=Zinc 2%3B in variant Michigan-1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009884;Dbxref=PMID:12009884
CA1	P00915	12	78	68	68	Natural variant	ID=VAR_001378;Note=In variant Michigan-1%3B confers enhanced esterase activity and an additional zinc binding site. H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12009884,ECO:0000269|PubMed:7866410;Dbxref=dbSNP:rs990757234,PMID:12009884,PMID:7866410
CA1	P00915	12	78	68	68	Natural variant	ID=VAR_001378;Note=In variant Michigan-1%3B confers enhanced esterase activity and an additional zinc binding site. H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12009884,ECO:0000269|PubMed:7866410;Dbxref=dbSNP:rs990757234,PMID:12009884,PMID:7866410
CA1	P00915	12	78	68	68	Natural variant	ID=VAR_001378;Note=In variant Michigan-1%3B confers enhanced esterase activity and an additional zinc binding site. H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12009884,ECO:0000269|PubMed:7866410;Dbxref=dbSNP:rs990757234,PMID:12009884,PMID:7866410
CA1	P00915	12	78	68	68	Natural variant	ID=VAR_001378;Note=In variant Michigan-1%3B confers enhanced esterase activity and an additional zinc binding site. H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12009884,ECO:0000269|PubMed:7866410;Dbxref=dbSNP:rs990757234,PMID:12009884,PMID:7866410
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	75	76	Sequence conflict	Note=DN->ND;Ontology_term=ECO:0000305;evidence=ECO:0000305
CA1	P00915	12	78	10	12	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	10	12	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	10	12	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	10	12	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	14	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	22	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	22	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	22	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	22	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	26	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J9W
CA1	P00915	12	78	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J9W
CA1	P00915	12	78	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J9W
CA1	P00915	12	78	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J9W
CA1	P00915	12	78	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	54	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	67	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	67	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	67	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	67	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	74	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	74	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	74	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	12	78	74	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	141	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	141	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	141	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	141	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	156	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	159	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	159	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	159	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	159	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	165	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	165	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	165	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CA1	P00915	150	171	165	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E2M
CDH3	P22223	523	598	108	829	Chain	ID=PRO_0000003746;Note=Cadherin-3
CDH3	P22223	598	667	108	829	Chain	ID=PRO_0000003746;Note=Cadherin-3
CDH3	P22223	523	598	108	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH3	P22223	598	667	108	654	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH3	P22223	598	667	655	677	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH3	P22223	523	598	441	546	Domain	Note=Cadherin 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH3	P22223	523	598	547	650	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH3	P22223	598	667	547	650	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH3	P22223	523	598	566	566	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH3	P22223	523	598	563	563	Natural variant	ID=VAR_031931;Note=Q->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15805154,ECO:0000269|PubMed:2793940,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1126933,PMID:14702039,PMID:15805154,PMID:2793940
CA4	P22748	138	171	19	284	Chain	ID=PRO_0000004226;Note=Carbonic anhydrase 4
CA4	P22748	138	171	21	285	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA4	P22748	138	171	140	140	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8942978;Dbxref=PMID:8942978
CA4	P22748	138	171	46	229	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8809084;Dbxref=PMID:8809084
CA4	P22748	138	171	107	312	Alternative sequence	ID=VSP_055974;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CA4	P22748	138	171	136	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FW3
CA4	P22748	138	171	153	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KU6
CA4	P22748	138	171	162	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FW3
CA5B	Q9Y2D0	47	113	34	317	Chain	ID=PRO_0000004237;Note=Carbonic anhydrase 5B%2C mitochondrial
CA5B	Q9Y2D0	153	185	34	317	Chain	ID=PRO_0000004237;Note=Carbonic anhydrase 5B%2C mitochondrial
CA5B	Q9Y2D0	47	113	34	317	Chain	ID=PRO_0000004237;Note=Carbonic anhydrase 5B%2C mitochondrial
CA5B	Q9Y2D0	153	185	34	317	Chain	ID=PRO_0000004237;Note=Carbonic anhydrase 5B%2C mitochondrial
CA5B	Q9Y2D0	47	113	37	296	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5B	Q9Y2D0	153	185	37	296	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5B	Q9Y2D0	47	113	37	296	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5B	Q9Y2D0	153	185	37	296	Domain	Note=Alpha-carbonic anhydrase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5B	Q9Y2D0	153	185	155	155	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CA5B	Q9Y2D0	153	185	155	155	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01134
CALML4	Q96GE6	54	101	1	196	Chain	ID=PRO_0000314933;Note=Calmodulin-like protein 4
CALML4	Q96GE6	54	101	51	86	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CALML4	Q96GE6	54	101	87	122	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CALML4	Q96GE6	54	101	1	115	Alternative sequence	ID=VSP_030435;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CALML4	Q96GE6	54	101	1	76	Alternative sequence	ID=VSP_030436;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334
CALML4	Q96GE6	54	101	45	59	Alternative sequence	ID=VSP_055513;Note=In isoform 5. AKFLSQDQINEYKEC->WMISSGKQISNPMAK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CALML4	Q96GE6	54	101	55	101	Alternative sequence	ID=VSP_047150;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CALML4	Q96GE6	54	101	60	196	Alternative sequence	ID=VSP_055514;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CALML4	Q96GE6	54	101	60	60	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
CALML4	Q96GE6	54	101	76	76	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAMLG	P49069	211	233	1	296	Chain	ID=PRO_0000089291;Note=Calcium signal-modulating cyclophilin ligand
CAMLG	P49069	211	233	211	240	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CAPN3	P20807	267	315	1	821	Chain	ID=PRO_0000207706;Note=Calpain-3
CAPN3	P20807	372	397	1	821	Chain	ID=PRO_0000207706;Note=Calpain-3
CAPN3	P20807	600	638	1	821	Chain	ID=PRO_0000207706;Note=Calpain-3
CAPN3	P20807	638	664	1	821	Chain	ID=PRO_0000207706;Note=Calpain-3
CAPN3	P20807	705	728	1	821	Chain	ID=PRO_0000207706;Note=Calpain-3
CAPN3	P20807	267	315	74	417	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN3	P20807	372	397	74	417	Domain	Note=Calpain catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00239
CAPN3	P20807	638	664	649	683	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN3	P20807	705	728	692	725	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN3	P20807	705	728	722	757	Domain	Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPN3	P20807	638	664	662	672	Calcium binding	Note=1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4OKH,ECO:0000269|PubMed:24846670;Dbxref=PMID:24846670
CAPN3	P20807	705	728	705	716	Calcium binding	Note=2;Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:4OKH,ECO:0000255|PROSITE-ProRule:PRU00448,ECO:0000269|PubMed:24846670;Dbxref=PMID:24846670
CAPN3	P20807	600	638	587	649	Region	Note=Linker
CAPN3	P20807	638	664	587	649	Region	Note=Linker
CAPN3	P20807	638	664	650	821	Region	Note=Domain IV
CAPN3	P20807	705	728	650	821	Region	Note=Domain IV
CAPN3	P20807	267	315	1	665	Alternative sequence	ID=VSP_044255;Note=In isoform V. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAPN3	P20807	372	397	1	665	Alternative sequence	ID=VSP_044255;Note=In isoform V. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAPN3	P20807	600	638	1	665	Alternative sequence	ID=VSP_044255;Note=In isoform V. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAPN3	P20807	638	664	1	665	Alternative sequence	ID=VSP_044255;Note=In isoform V. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CAPN3	P20807	267	315	1	512	Alternative sequence	ID=VSP_007813;Note=In isoform IV. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
CAPN3	P20807	372	397	1	512	Alternative sequence	ID=VSP_007813;Note=In isoform IV. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.4;Dbxref=PMID:15489334
CAPN3	P20807	267	315	268	315	Alternative sequence	ID=VSP_005227;Note=In isoform II. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CAPN3	P20807	600	638	595	638	Alternative sequence	ID=VSP_005228;Note=In isoform II. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CAPN3	P20807	638	664	595	638	Alternative sequence	ID=VSP_005228;Note=In isoform II. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CAPN3	P20807	600	638	595	600	Alternative sequence	ID=VSP_005229;Note=In isoform III. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CAPN3	P20807	267	315	266	267	Natural variant	ID=VAR_076561;Note=In LGMD2A. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27020652,ECO:0000269|PubMed:27234031;Dbxref=PMID:27020652,PMID:27234031
CAPN3	P20807	600	638	606	606	Natural variant	ID=VAR_009591;Note=In LGMD2A. S->L;Dbxref=dbSNP:rs199806879
CAPN3	P20807	600	638	622	622	Natural variant	ID=VAR_047691;Note=E->A;Dbxref=dbSNP:rs11557723
CAPN3	P20807	600	638	638	638	Natural variant	ID=VAR_009592;Note=In LGMD2A. Q->P
CAPN3	P20807	638	664	638	638	Natural variant	ID=VAR_009592;Note=In LGMD2A. Q->P
CAPN3	P20807	705	728	705	705	Natural variant	ID=VAR_009595;Note=In LGMD2A. D->G
CAPN3	P20807	705	728	705	705	Natural variant	ID=VAR_009596;Note=In LGMD2A. D->H
CAPN3	P20807	372	397	374	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BDT
CAPN3	P20807	372	397	381	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BDT
CAPN3	P20807	372	397	394	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BDT
CAPN3	P20807	638	664	654	662	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OKH
CAPN3	P20807	638	664	663	666	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OKH
CAPN3	P20807	705	728	708	712	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OKH
CAPN3	P20807	705	728	714	734	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OKH
CAPSL	Q8WWF8	0	45	1	208	Chain	ID=PRO_0000264473;Note=Calcyphosin-like protein
CAPSL	Q8WWF8	0	45	39	74	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
CAPSL	Q8WWF8	0	45	24	24	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CPA4	Q9UI42	95	128	17	113	Propeptide	ID=PRO_0000004357;Note=Activation peptide;Ontology_term=ECO:0000255;evidence=ECO:0000255
CPA4	Q9UI42	95	128	114	421	Chain	ID=PRO_0000004358;Note=Carboxypeptidase A4
CPA4	Q9UI42	162	197	114	421	Chain	ID=PRO_0000004358;Note=Carboxypeptidase A4
CPA4	Q9UI42	162	197	181	184	Region	Note=Substrate binding
CPA4	Q9UI42	162	197	181	181	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22294694;Dbxref=PMID:22294694
CPA4	Q9UI42	162	197	184	184	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22294694;Dbxref=PMID:22294694
CPA4	Q9UI42	95	128	96	128	Alternative sequence	ID=VSP_042894;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPA4	Q9UI42	162	197	183	183	Natural variant	ID=VAR_048595;Note=R->L;Dbxref=dbSNP:rs3735053
CPA4	Q9UI42	95	128	94	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BOA
CPA4	Q9UI42	95	128	120	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BOA
CPA4	Q9UI42	95	128	126	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
CPA4	Q9UI42	162	197	157	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
CPA4	Q9UI42	162	197	173	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
CPA4	Q9UI42	162	197	185	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BO9
CBLC	Q9ULV8	260	305	1	474	Chain	ID=PRO_0000055866;Note=E3 ubiquitin-protein ligase CBL-C
CBLC	Q9ULV8	335	379	1	474	Chain	ID=PRO_0000055866;Note=E3 ubiquitin-protein ligase CBL-C
CBLC	Q9ULV8	428	454	1	474	Chain	ID=PRO_0000055866;Note=E3 ubiquitin-protein ligase CBL-C
CBLC	Q9ULV8	260	305	7	321	Domain	Note=Cbl-PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00839
CBLC	Q9ULV8	335	379	351	390	Zinc finger	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
CBLC	Q9ULV8	260	305	219	321	Region	Note=SH2-like
CBLC	Q9ULV8	335	379	322	350	Region	Note=Linker
CBLC	Q9ULV8	335	379	351	474	Region	Note=Interaction with RET;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18753381;Dbxref=PMID:18753381
CBLC	Q9ULV8	428	454	351	474	Region	Note=Interaction with RET;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18753381;Dbxref=PMID:18753381
CBLC	Q9ULV8	260	305	264	264	Binding site	Note=Phosphotyrosine
CBLC	Q9ULV8	335	379	341	341	Modified residue	Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:20525694,PMID:23145173
CBLC	Q9ULV8	260	305	261	306	Alternative sequence	ID=VSP_005732;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10362357;Dbxref=PMID:10362357
CBLC	Q9ULV8	260	305	264	264	Mutagenesis	Note=Abolishes interaction with EGFR. Decreases interaction with SRC and abolishes SRC ubiquitination. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118
CBLC	Q9ULV8	260	305	265	265	Mutagenesis	Note=Enhances interaction with EGFR and SRC as well as SRC ubiquitination. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118
CBLC	Q9ULV8	260	305	266	266	Mutagenesis	Note=Decreases interactions with EGFR and SRC as well as SRC ubiquitination. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118
CBLC	Q9ULV8	260	305	268	268	Mutagenesis	Note=Abolishes interaction with EGFR. Decreases interaction with and ubiquitination of SRC. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118
CBLC	Q9ULV8	260	305	276	276	Mutagenesis	Note=No effect on interaction with RET. Binds slightly to SRC%2C this interaction is independent of SRC phosphorylation. Strongly decreases SRC ubiquitination. Abolishes interaction with EGFR. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:18753381,ECO:0000269|PubMed:22888118;Dbxref=PMID:14661060,PMID:18753381,PMID:22888118
CBLC	Q9ULV8	335	379	341	341	Mutagenesis	Note=Induces E3 activity and autoubiquitination. Releases ubiquitin-conjugating enzyme E2 UBE2D2 faster. Y->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:20525694,PMID:23145173
CBLC	Q9ULV8	335	379	341	341	Mutagenesis	Note=Abolishes activation by EGF stimulation and enhancement by TGFB1I1 of E3 activity. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:20525694,PMID:23145173
CBLC	Q9ULV8	335	379	341	341	Mutagenesis	Note=Abolishes E3 activity. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:20525694,PMID:23145173
CBLC	Q9ULV8	335	379	351	351	Mutagenesis	Note=No effect on TGFB1I1 and SRC interactions. Abolishes SRC ubiquitination. Abolishes interaction with TGFB1I1%3B when associated with A-366. Abolishes interaction with RET and inhibition of RET degradation. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:18753381,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:18753381,PMID:23145173
CBLC	Q9ULV8	335	379	366	366	Mutagenesis	Note=Abolishes interaction with TGFB1I1. Abolishes interaction with TGFB1I1%3B when associated with A-351. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23145173;Dbxref=PMID:23145173
CBLC	Q9ULV8	260	305	260	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VRP
CBLC	Q9ULV8	260	305	267	269	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VRP
CBLC	Q9ULV8	260	305	273	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VRP
CBLC	Q9ULV8	260	305	284	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VRP
CBLC	Q9ULV8	260	305	294	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VRP
CDH24	Q86UP0	570	653	45	819	Chain	ID=PRO_0000003828;Note=Cadherin-24
CDH24	Q86UP0	454	492	45	819	Chain	ID=PRO_0000003828;Note=Cadherin-24
CDH24	Q86UP0	570	653	45	819	Chain	ID=PRO_0000003828;Note=Cadherin-24
CDH24	Q86UP0	454	492	45	819	Chain	ID=PRO_0000003828;Note=Cadherin-24
CDH24	Q86UP0	570	653	45	641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH24	Q86UP0	454	492	45	641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH24	Q86UP0	570	653	45	641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH24	Q86UP0	454	492	45	641	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH24	Q86UP0	570	653	642	662	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH24	Q86UP0	570	653	642	662	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CDH24	Q86UP0	454	492	375	517	Domain	Note=Cadherin 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH24	Q86UP0	454	492	375	517	Domain	Note=Cadherin 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH24	Q86UP0	570	653	517	630	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH24	Q86UP0	570	653	517	630	Domain	Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043
CDH24	Q86UP0	454	492	428	492	Alternative sequence	ID=VSP_008719;Note=In isoform 3. EGTIHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQ->MNIVCTWYCSIHSATLFSTCTLHAYFMCFLCMLYASCGIHAHAPHMLRVNCVVCVWRVCFGVLPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CDH24	Q86UP0	454	492	428	492	Alternative sequence	ID=VSP_008719;Note=In isoform 3. EGTIHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQ->MNIVCTWYCSIHSATLFSTCTLHAYFMCFLCMLYASCGIHAHAPHMLRVNCVVCVWRVCFGVLPS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CDH24	Q86UP0	454	492	455	492	Alternative sequence	ID=VSP_008717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12734196,ECO:0000303|PubMed:12975309;Dbxref=PMID:12734196,PMID:12975309
CDH24	Q86UP0	454	492	455	492	Alternative sequence	ID=VSP_008717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12734196,ECO:0000303|PubMed:12975309;Dbxref=PMID:12734196,PMID:12975309
CACNA1D	Q01668	1290	1305	1	2161	Chain	ID=PRO_0000053933;Note=Voltage-dependent L-type calcium channel subunit alpha-1D
CACNA1D	Q01668	1290	1305	1289	1313	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNA1D	Q01668	1290	1305	1192	1467	Repeat	Note=IV
CACNA1D	Q01668	1290	1305	1291	1305	Alternative sequence	ID=VSP_046743;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18482979;Dbxref=PMID:18482979
CACNA1D	Q01668	1290	1305	1289	1290	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CAPG	P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
CAPG	P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
CAPG	P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
CAPG	P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
CAPG	P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
CAPG	P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
CAPG	P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
CAPG	P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
CAPG	P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
CAPG	P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CAPG	P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CAPG	P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
CAPG	P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CAPG	P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1J72
CARD10	Q9BWT7	303	355	1	1032	Chain	ID=PRO_0000144084;Note=Caspase recruitment domain-containing protein 10
CARD10	Q9BWT7	78	124	1	1032	Chain	ID=PRO_0000144084;Note=Caspase recruitment domain-containing protein 10
CARD10	Q9BWT7	303	355	1	1032	Chain	ID=PRO_0000144084;Note=Caspase recruitment domain-containing protein 10
CARD10	Q9BWT7	78	124	1	1032	Chain	ID=PRO_0000144084;Note=Caspase recruitment domain-containing protein 10
CARD10	Q9BWT7	78	124	23	115	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
CARD10	Q9BWT7	78	124	23	115	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
CARD10	Q9BWT7	303	355	138	456	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CARD10	Q9BWT7	303	355	138	456	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CARD10	Q9BWT7	303	355	18	303	Alternative sequence	ID=VSP_055524;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CARD10	Q9BWT7	78	124	18	303	Alternative sequence	ID=VSP_055524;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CARD10	Q9BWT7	303	355	18	303	Alternative sequence	ID=VSP_055524;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CARD10	Q9BWT7	78	124	18	303	Alternative sequence	ID=VSP_055524;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CPA2	P48052	96	128	19	114	Propeptide	ID=PRO_0000004353;Note=Activation peptide;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8318831;Dbxref=PMID:8318831
CPA2	P48052	96	128	115	419	Chain	ID=PRO_0000004354;Note=Carboxypeptidase A2
CPA2	P48052	128	162	115	419	Chain	ID=PRO_0000004354;Note=Carboxypeptidase A2
CPA2	P48052	162	195	115	419	Chain	ID=PRO_0000004354;Note=Carboxypeptidase A2
CPA2	P48052	162	195	179	182	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00730
CPA2	P48052	162	195	179	179	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10742178,ECO:0000269|PubMed:9384570;Dbxref=PMID:10742178,PMID:9384570
CPA2	P48052	162	195	182	182	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10742178,ECO:0000269|PubMed:9384570;Dbxref=PMID:10742178,PMID:9384570
CPA2	P48052	96	128	95	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AYE
CPA2	P48052	96	128	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AYE
CPA2	P48052	96	128	120	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AYE
CPA2	P48052	96	128	126	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	128	162	126	139	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	128	162	141	143	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	128	162	144	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	128	162	157	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	162	195	157	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	162	195	166	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	162	195	171	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CPA2	P48052	162	195	183	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DTD
CBX4	O00257	38	59	1	560	Chain	ID=PRO_0000080206;Note=E3 SUMO-protein ligase CBX4
CBX4	O00257	38	59	11	69	Domain	Note=Chromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053
CBX4	O00257	38	59	1	539	Region	Note=Interaction with BMI1
CBX4	O00257	38	59	1	75	Region	Note=Involved in interaction with HIST2H3A and HIST1H3A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18927235;Dbxref=PMID:18927235
CBX4	O00257	38	59	37	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I8Z
CBX4	O00257	38	59	41	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I8Z
CBX4	O00257	38	59	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I8Z
CBX4	O00257	38	59	51	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I8Z
CCDC170	Q8IYT3	258	364	1	715	Chain	ID=PRO_0000255256;Note=Coiled-coil domain-containing protein 170
CCDC170	Q8IYT3	364	431	1	715	Chain	ID=PRO_0000255256;Note=Coiled-coil domain-containing protein 170
CCDC170	Q8IYT3	258	364	30	286	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC170	Q8IYT3	258	364	360	418	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC170	Q8IYT3	364	431	360	418	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC170	Q8IYT3	258	364	269	269	Natural variant	ID=VAR_028856;Note=A->V;Dbxref=dbSNP:rs12205837
CCDC170	Q8IYT3	258	364	324	324	Natural variant	ID=VAR_028857;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs953767,PMID:14702039
CCDC170	Q8IYT3	258	364	331	331	Natural variant	ID=VAR_028858;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855718,PMID:15489334
CCDC170	Q8IYT3	258	364	345	345	Natural variant	ID=VAR_061591;Note=E->K;Dbxref=dbSNP:rs55868409
CCDC171	Q6TFL3	181	225	1	1326	Chain	ID=PRO_0000089727;Note=Coiled-coil domain-containing protein 171
CCDC171	Q6TFL3	225	274	1	1326	Chain	ID=PRO_0000089727;Note=Coiled-coil domain-containing protein 171
CCDC171	Q6TFL3	497	564	1	1326	Chain	ID=PRO_0000089727;Note=Coiled-coil domain-containing protein 171
CCDC171	Q6TFL3	1156	1200	1	1326	Chain	ID=PRO_0000089727;Note=Coiled-coil domain-containing protein 171
CCDC171	Q6TFL3	1200	1251	1	1326	Chain	ID=PRO_0000089727;Note=Coiled-coil domain-containing protein 171
CCDC171	Q6TFL3	181	225	53	294	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC171	Q6TFL3	225	274	53	294	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC171	Q6TFL3	497	564	450	561	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC171	Q6TFL3	1200	1251	1217	1241	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC171	Q6TFL3	181	225	103	377	Compositional bias	Note=Glu-rich
CCDC171	Q6TFL3	225	274	103	377	Compositional bias	Note=Glu-rich
CCDC171	Q6TFL3	1200	1251	1201	1229	Alternative sequence	ID=VSP_014445;Note=In isoform 2. AMIKSFMDVYQLASTRIMTLEKEMTSHRS->VRVQWCDHSSLQSQMPGLKQSSCLSLLST;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CCDC171	Q6TFL3	1200	1251	1230	1326	Alternative sequence	ID=VSP_014446;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
CCDC90B	Q9GZT6	180	198	43	254	Chain	ID=PRO_0000295695;Note=Coiled-coil domain-containing protein 90B%2C mitochondrial
CCDC90B	Q9GZT6	142	156	43	254	Chain	ID=PRO_0000295695;Note=Coiled-coil domain-containing protein 90B%2C mitochondrial
CCDC90B	Q9GZT6	108	142	43	254	Chain	ID=PRO_0000295695;Note=Coiled-coil domain-containing protein 90B%2C mitochondrial
CCDC90B	Q9GZT6	142	156	129	164	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC90B	Q9GZT6	108	142	129	164	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC50	Q8IVM0	16	37	2	306	Chain	ID=PRO_0000066307;Note=Coiled-coil domain-containing protein 50
CCDC50	Q8IVM0	149	325	2	306	Chain	ID=PRO_0000066307;Note=Coiled-coil domain-containing protein 50
CCDC50	Q8IVM0	149	325	214	250	Compositional bias	Note=Lys-rich
CCDC50	Q8IVM0	149	325	266	269	Compositional bias	Note=Poly-Pro
CCDC50	Q8IVM0	149	325	149	149	Alternative sequence	ID=VSP_014985;Note=In isoform 2. G->GDQPGSRRARELGSGFSRPCRLQRDGKTVKHKKEKPEHPLENLEEPEQHCSSKRSLSSSSSGKGRDNPHINNEQHERKRSTQERPRRPLLPTISGEVFLSTECDDWETKINHQTRNWEKQSRHQDRLSPKSSQKAGLHCKEVVYGRDHGQGEHRKRRHRPRTPPFSESEEQLHLHDA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14527723;Dbxref=PMID:14527723
CCDC50	Q8IVM0	149	325	156	156	Natural variant	ID=VAR_050755;Note=M->T;Dbxref=dbSNP:rs293813
CCDC18	Q5T9S5	609	653	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	724	763	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	763	819	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	1026	1065	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	1065	1113	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	1227	1294	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	1294	1450	1	1454	Chain	ID=PRO_0000284775;Note=Coiled-coil domain-containing protein 18
CCDC18	Q5T9S5	609	653	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	724	763	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	763	819	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	1026	1065	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	1065	1113	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	1227	1294	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	1294	1450	508	1309	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC18	Q5T9S5	1294	1450	1355	1355	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CCDC18	Q5T9S5	1294	1450	1295	1450	Alternative sequence	ID=VSP_024636;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC61	Q9Y6R9	130	183	1	512	Chain	ID=PRO_0000311255;Note=Coiled-coil domain-containing protein 61
CCDC61	Q9Y6R9	130	183	175	277	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC66	A2RUB6	312	356	1	948	Chain	ID=PRO_0000320037;Note=Coiled-coil domain-containing protein 66
CCDC66	A2RUB6	312	356	231	948	Alternative sequence	ID=VSP_036546;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC66	A2RUB6	312	356	288	948	Alternative sequence	ID=VSP_031587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC66	A2RUB6	312	356	208	948	Mutagenesis	Note=Loss of association with microtubules and localization to centrosomes. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28235840;Dbxref=PMID:28235840
CSN1S1	P47710	100	114	16	185	Chain	ID=PRO_0000004450;Note=Alpha-S1-casein
CSN1S1	P47710	100	114	93	100	Alternative sequence	ID=VSP_046130;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
CASC3	O15234	203	261	1	703	Chain	ID=PRO_0000089324;Note=Protein CASC3
CASC3	O15234	550	583	1	703	Chain	ID=PRO_0000089324;Note=Protein CASC3
CASC3	O15234	203	261	137	283	Region	Note=Necessary for RNA-binding%2C interaction with MAGOH and localization in nucleus speckles;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15166247;Dbxref=PMID:15166247
CASC3	O15234	203	261	137	283	Region	Note=Sufficient to form the EJC
CASC3	O15234	550	583	377	703	Region	Note=Necessary for localization in cytoplasmic stress granules
CASC3	O15234	203	261	204	210	Motif	Note=Nuclear localization signal 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASC3	O15234	203	261	254	262	Motif	Note=Nuclear localization signal 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASC3	O15234	203	261	218	218	Mutagenesis	Note=Abolishes interaction with EIF4A3%2C EJC formation and localization in nucleus speckles. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16170325;Dbxref=PMID:16170325
CASC3	O15234	203	261	220	221	Mutagenesis	Note=Abolishes interaction with EIF4A3%2C EJC formation and localization in nucleus speckles. HD->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16170325;Dbxref=PMID:16170325
CASC3	O15234	203	261	240	241	Mutagenesis	Note=Abolishes interaction with EIF4A3%2C EJC formation and localization in nucleus speckles. YG->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16170325;Dbxref=PMID:16170325
CASC3	O15234	203	261	226	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0S
CASC3	O15234	203	261	233	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYI
CASC3	O15234	203	261	244	246	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EX7
CASP1	P29466	91	112	1	119	Propeptide	ID=PRO_0000004521
CASP1	P29466	91	112	1	119	Propeptide	ID=PRO_0000004521
CASP1	P29466	287	335	120	297	Chain	ID=PRO_0000004522;Note=Caspase-1 subunit p20
CASP1	P29466	287	335	120	297	Chain	ID=PRO_0000004522;Note=Caspase-1 subunit p20
CASP1	P29466	287	335	298	316	Propeptide	ID=PRO_0000004523
CASP1	P29466	287	335	298	316	Propeptide	ID=PRO_0000004523
CASP1	P29466	287	335	317	404	Chain	ID=PRO_0000004524;Note=Caspase-1 subunit p10
CASP1	P29466	287	335	317	404	Chain	ID=PRO_0000004524;Note=Caspase-1 subunit p10
CASP1	P29466	91	112	1	91	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
CASP1	P29466	91	112	1	91	Domain	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046
CASP1	P29466	287	335	302	302	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29452
CASP1	P29466	287	335	302	302	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29452
CASP1	P29466	287	335	20	335	Alternative sequence	ID=VSP_000797;Note=In isoform Epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876192;Dbxref=PMID:7876192
CASP1	P29466	91	112	20	335	Alternative sequence	ID=VSP_000797;Note=In isoform Epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876192;Dbxref=PMID:7876192
CASP1	P29466	287	335	20	335	Alternative sequence	ID=VSP_000797;Note=In isoform Epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876192;Dbxref=PMID:7876192
CASP1	P29466	91	112	20	335	Alternative sequence	ID=VSP_000797;Note=In isoform Epsilon. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876192;Dbxref=PMID:7876192
CASP1	P29466	91	112	20	112	Alternative sequence	ID=VSP_000799;Note=In isoform Gamma and isoform Delta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7876192;Dbxref=PMID:15489334,PMID:7876192
CASP1	P29466	91	112	20	112	Alternative sequence	ID=VSP_000799;Note=In isoform Gamma and isoform Delta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7876192;Dbxref=PMID:15489334,PMID:7876192
CASP1	P29466	91	112	92	112	Alternative sequence	ID=VSP_000798;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7876192;Dbxref=PMID:15489334,PMID:7876192
CASP1	P29466	91	112	92	112	Alternative sequence	ID=VSP_000798;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7876192;Dbxref=PMID:15489334,PMID:7876192
CASP1	P29466	287	335	288	335	Alternative sequence	ID=VSP_000800;Note=In isoform Delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876192;Dbxref=PMID:7876192
CASP1	P29466	287	335	288	335	Alternative sequence	ID=VSP_000800;Note=In isoform Delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7876192;Dbxref=PMID:7876192
CASP1	P29466	287	335	319	319	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASP1	P29466	287	335	319	319	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASP1	P29466	287	335	287	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SC3
CASP1	P29466	287	335	287	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SC3
CASP1	P29466	287	335	291	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E4C
CASP1	P29466	287	335	291	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E4C
CASP1	P29466	287	335	316	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E4C
CASP1	P29466	287	335	316	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E4C
CASP1	P29466	287	335	326	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SC3
CASP1	P29466	287	335	326	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SC3
CTSF	Q9UBX1	321	348	271	484	Chain	ID=PRO_0000026203;Note=Cathepsin F
CTSF	Q9UBX1	321	348	292	333	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12225749;Dbxref=PMID:12225749
CTSF	Q9UBX1	321	348	326	366	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12225749;Dbxref=PMID:12225749
CTSF	Q9UBX1	321	348	321	321	Natural variant	ID=VAR_070160;Note=In CLN13. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23297359;Dbxref=dbSNP:rs397514731,PMID:23297359
CTSF	Q9UBX1	321	348	320	326	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6D
CTSF	Q9UBX1	321	348	328	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6D
CTSF	Q9UBX1	321	348	338	348	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M6D
C2orf76	Q3KRA6	44	61	1	126	Chain	ID=PRO_0000325824;Note=UPF0538 protein C2orf76
C2orf76	Q3KRA6	44	61	1	126	Chain	ID=PRO_0000325824;Note=UPF0538 protein C2orf76
C2orf76	Q3KRA6	44	61	1	126	Chain	ID=PRO_0000325824;Note=UPF0538 protein C2orf76
C2orf76	Q3KRA6	44	61	1	126	Chain	ID=PRO_0000325824;Note=UPF0538 protein C2orf76
C2orf76	Q3KRA6	44	61	46	46	Natural variant	ID=VAR_039931;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1132267,PMID:15489334
C2orf76	Q3KRA6	44	61	46	46	Natural variant	ID=VAR_039931;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1132267,PMID:15489334
C2orf76	Q3KRA6	44	61	46	46	Natural variant	ID=VAR_039931;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1132267,PMID:15489334
C2orf76	Q3KRA6	44	61	46	46	Natural variant	ID=VAR_039931;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1132267,PMID:15489334
TMEM30A	Q9NV96	115	151	2	361	Chain	ID=PRO_0000244469;Note=Cell cycle control protein 50A
TMEM30A	Q9NV96	115	151	71	325	Topological domain	Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMEM30A	Q9NV96	115	151	1	119	Alternative sequence	ID=VSP_019567;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CCDC74B	Q96LY2	98	181	1	380	Chain	ID=PRO_0000274375;Note=Coiled-coil domain-containing protein 74B
CCDC74B	Q96LY2	98	181	100	165	Alternative sequence	ID=VSP_022730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC74B	Q96LY2	98	181	169	169	Natural variant	ID=VAR_030269;Note=T->M;Dbxref=dbSNP:rs184349150
CDC14B	O60729	448	486	1	498	Chain	ID=PRO_0000094878;Note=Dual specificity protein phosphatase CDC14B
CDC14B	O60729	188	209	1	498	Chain	ID=PRO_0000094878;Note=Dual specificity protein phosphatase CDC14B
CDC14B	O60729	188	209	44	198	Region	Note=A
CDC14B	O60729	188	209	199	212	Region	Note=Linker
CDC14B	O60729	448	486	449	498	Alternative sequence	ID=VSP_012039;Note=In isoform 3. VILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKTVLR->DGWLSQAVTFLDRLLIWLGIHKD;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
CDC14B	O60729	448	486	449	498	Alternative sequence	ID=VSP_030720;Note=In isoform 4. VILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKTVLR->CPLAVLTSALCSVVIWWIVCDYILPILLFCLDGFRTQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CDC14B	O60729	448	486	449	487	Alternative sequence	ID=VSP_012038;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9367992;Dbxref=PMID:9367992
CDC14B	O60729	188	209	179	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OHE
CDC14B	O60729	188	209	197	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OHE
CDC14B	O60729	188	209	202	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OHE
CCDC30	Q5VVM6	39	85	1	783	Chain	ID=PRO_0000336044;Note=Coiled-coil domain-containing protein 30
CCDC30	Q5VVM6	285	355	1	783	Chain	ID=PRO_0000336044;Note=Coiled-coil domain-containing protein 30
CCDC30	Q5VVM6	39	85	1	783	Chain	ID=PRO_0000336044;Note=Coiled-coil domain-containing protein 30
CCDC30	Q5VVM6	285	355	1	783	Chain	ID=PRO_0000336044;Note=Coiled-coil domain-containing protein 30
CCDC30	Q5VVM6	39	85	22	98	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC30	Q5VVM6	39	85	22	98	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC30	Q5VVM6	285	355	165	497	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC30	Q5VVM6	285	355	165	497	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC30	Q5VVM6	39	85	1	211	Alternative sequence	ID=VSP_033791;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16710767;Dbxref=PMID:16710767
CCDC30	Q5VVM6	39	85	1	211	Alternative sequence	ID=VSP_033791;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16710767;Dbxref=PMID:16710767
CCDC97	Q96F63	167	260	1	343	Chain	ID=PRO_0000286096;Note=Coiled-coil domain-containing protein 97
CCDC97	Q96F63	167	260	224	262	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC42	Q96M95	164	238	1	316	Chain	ID=PRO_0000234498;Note=Coiled-coil domain-containing protein 42
CCDC42	Q96M95	164	238	178	232	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC42	Q96M95	164	238	165	238	Alternative sequence	ID=VSP_055651;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CACNG6	Q9BXT2	135	181	1	260	Chain	ID=PRO_0000164684;Note=Voltage-dependent calcium channel gamma-6 subunit
CACNG6	Q9BXT2	135	181	143	163	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CACNG6	Q9BXT2	135	181	169	189	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CCNB1	P14635	182	235	1	433	Chain	ID=PRO_0000080350;Note=G2/mitotic-specific cyclin-B1
CCNB1	P14635	314	361	1	433	Chain	ID=PRO_0000080350;Note=G2/mitotic-specific cyclin-B1
CCNB1	P14635	361	398	1	433	Chain	ID=PRO_0000080350;Note=G2/mitotic-specific cyclin-B1
CCNB1	P14635	314	361	321	321	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
CCNB1	P14635	361	398	362	398	Alternative sequence	ID=VSP_053892;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CCNB1	P14635	182	235	171	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	182	235	189	194	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	182	235	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YC3
CCNB1	P14635	182	235	199	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	182	235	220	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	314	361	317	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	314	361	334	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	314	361	337	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B9R
CCNB1	P14635	314	361	341	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	361	398	363	369	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB1	P14635	361	398	373	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CCNB3	Q8WWL7	1141	1172	1	1395	Chain	ID=PRO_0000080373;Note=G2/mitotic-specific cyclin-B3
CCNB3	Q8WWL7	1141	1172	1	1395	Chain	ID=PRO_0000080373;Note=G2/mitotic-specific cyclin-B3
CCNB3	Q8WWL7	1141	1172	69	1172	Alternative sequence	ID=VSP_010514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
CCNB3	Q8WWL7	1141	1172	69	1172	Alternative sequence	ID=VSP_010514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
CCNB3	Q8WWL7	1141	1172	112	1395	Alternative sequence	ID=VSP_010515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
CCNB3	Q8WWL7	1141	1172	112	1395	Alternative sequence	ID=VSP_010515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
ALCAM	Q13740	502	515	28	583	Chain	ID=PRO_0000014659;Note=CD166 antigen
ALCAM	Q13740	502	515	28	527	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALCAM	Q13740	502	515	134	583	Alternative sequence	ID=VSP_053531;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15496415;Dbxref=PMID:15489334,PMID:15496415
ALCAM	Q13740	502	515	503	516	Alternative sequence	ID=VSP_021797;Note=In isoform 2. ISIPEHDEADEISD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
CD53	P19397	21	84	1	219	Chain	ID=PRO_0000219212;Note=Leukocyte surface antigen CD53
CD53	P19397	84	109	1	219	Chain	ID=PRO_0000219212;Note=Leukocyte surface antigen CD53
CD53	P19397	109	141	1	219	Chain	ID=PRO_0000219212;Note=Leukocyte surface antigen CD53
CD53	P19397	141	168	1	219	Chain	ID=PRO_0000219212;Note=Leukocyte surface antigen CD53
CD53	P19397	168	196	1	219	Chain	ID=PRO_0000219212;Note=Leukocyte surface antigen CD53
CD53	P19397	21	84	12	32	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	21	84	33	54	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	21	84	55	69	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	21	84	70	80	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	21	84	81	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	84	109	81	106	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	84	109	107	181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	109	141	107	181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	141	168	107	181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	168	196	107	181	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	168	196	182	206	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	109	141	129	129	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD53	P19397	141	168	148	148	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CTSE	P14091	221	261	54	396	Chain	ID=PRO_0000025975;Note=Cathepsin E form I
CTSE	P14091	221	261	57	396	Chain	ID=PRO_0000354668;Note=Cathepsin E form II
CTSE	P14091	221	261	78	396	Domain	Note=Peptidase A1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01103
CTSE	P14091	221	261	230	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TZS
CTSE	P14091	221	261	238	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TZS
CTSE	P14091	221	261	246	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TZS
CTSE	P14091	221	261	253	256	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TZS
CTSE	P14091	221	261	257	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TZS
CAB39L	Q9H9S4	230	278	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	208	230	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	188	208	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	37	92	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	230	278	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	208	230	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	188	208	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	37	92	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	230	278	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	208	230	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	188	208	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	37	92	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	230	278	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	208	230	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	188	208	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	37	92	1	337	Chain	ID=PRO_0000209826;Note=Calcium-binding protein 39-like
CAB39L	Q9H9S4	37	92	38	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	38	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	38	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	38	53	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	66	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	66	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	66	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	66	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	78	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	78	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	78	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	78	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	91	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	91	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	91	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	37	92	91	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	177	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	177	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	177	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	177	192	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	195	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	195	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	195	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	195	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	188	208	206	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	208	230	222	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	242	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	242	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	242	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	242	248	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	252	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	252	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	252	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	252	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	267	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	267	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	267	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CAB39L	Q9H9S4	230	278	267	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHP
CCDC88B	A6NC98	485	872	1	1476	Chain	ID=PRO_0000317454;Note=Coiled-coil domain-containing protein 88B
CCDC88B	A6NC98	954	986	1	1476	Chain	ID=PRO_0000317454;Note=Coiled-coil domain-containing protein 88B
CCDC88B	A6NC98	1119	1166	1	1476	Chain	ID=PRO_0000317454;Note=Coiled-coil domain-containing protein 88B
CCDC88B	A6NC98	1435	1458	1	1476	Chain	ID=PRO_0000317454;Note=Coiled-coil domain-containing protein 88B
CCDC88B	A6NC98	485	872	720	1303	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC88B	A6NC98	954	986	720	1303	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC88B	A6NC98	1119	1166	720	1303	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC88B	A6NC98	485	872	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
CCDC88B	A6NC98	485	872	1	1337	Alternative sequence	ID=VSP_035405;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
CCDC88B	A6NC98	954	986	1	1337	Alternative sequence	ID=VSP_035405;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
CCDC88B	A6NC98	1119	1166	1	1337	Alternative sequence	ID=VSP_035405;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
CCDC88B	A6NC98	485	872	1	864	Alternative sequence	ID=VSP_030956;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC88B	A6NC98	485	872	865	872	Alternative sequence	ID=VSP_030959;Note=In isoform 5. REKEALQA->MKNRGLRE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC88B	A6NC98	954	986	955	972	Alternative sequence	ID=VSP_030960;Note=In isoform 3. LRQGPAGLGPKKRAEPQL->VMPARLGAGGHATLPSIP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC88B	A6NC98	954	986	973	1476	Alternative sequence	ID=VSP_030961;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC88B	A6NC98	1119	1166	973	1476	Alternative sequence	ID=VSP_030961;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC88B	A6NC98	1435	1458	973	1476	Alternative sequence	ID=VSP_030961;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CCDC88B	A6NC98	1119	1166	1019	1136	Alternative sequence	ID=VSP_030963;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
CCDC88B	A6NC98	1119	1166	1035	1476	Alternative sequence	ID=VSP_030964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
CCDC88B	A6NC98	1435	1458	1035	1476	Alternative sequence	ID=VSP_030964;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
CCDC88B	A6NC98	1435	1458	1320	1476	Alternative sequence	ID=VSP_030965;Note=In isoform 5. VKRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHSKGPGVGWENSAETLQEHETDANREGPEVQEPEKRPLTPSLSQ->GPLPRHPCAGPRAPSACGMRPWQAGSGGNSAQGSRWGEALSHSALGTPLGNDSDSAIQAPWGRPSPTAKDLVWDGRTPLRPCRNTKQMPTERALRYRNRRNVPSPHPSASDTVGTAGLGVQPSRHWSVSGGPRQPKSSGSQGPQGESLDKEAWALRSSTVSAGARRWSWDECVDRGDGWPPRAAPGWSSGSSRWLPLRQRSLGDPPAEGGWQELAREPPALSRWEAESQCWGTVAWADLEP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC88B	A6NC98	485	872	639	639	Natural variant	ID=VAR_038524;Note=W->R;Dbxref=dbSNP:rs685870
CCDC60	Q8IWA6	150	185	1	550	Chain	ID=PRO_0000239665;Note=Coiled-coil domain-containing protein 60
CCDC60	Q8IWA6	323	346	1	550	Chain	ID=PRO_0000239665;Note=Coiled-coil domain-containing protein 60
CCDC60	Q8IWA6	368	409	1	550	Chain	ID=PRO_0000239665;Note=Coiled-coil domain-containing protein 60
CCDC60	Q8IWA6	410	453	1	550	Chain	ID=PRO_0000239665;Note=Coiled-coil domain-containing protein 60
CCDC60	Q8IWA6	368	409	393	393	Natural variant	ID=VAR_033669;Note=V->I;Dbxref=dbSNP:rs16949292
CCDC80	Q76M96	808	835	22	950	Chain	ID=PRO_0000282418;Note=Coiled-coil domain-containing protein 80
CCDC80	Q76M96	808	835	22	950	Chain	ID=PRO_0000282418;Note=Coiled-coil domain-containing protein 80
CCDC80	Q76M96	808	835	1	865	Alternative sequence	ID=VSP_024135;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC80	Q76M96	808	835	1	865	Alternative sequence	ID=VSP_024135;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC83	Q8IWF9	114	170	1	413	Chain	ID=PRO_0000288881;Note=Coiled-coil domain-containing protein 83
CCDC83	Q8IWF9	114	170	37	184	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC83	Q8IWF9	114	170	115	170	Alternative sequence	ID=VSP_025809;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
CCDC91	Q7Z6B0	192	218	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	218	254	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	254	285	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	367	405	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	192	218	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	218	254	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	254	285	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	367	405	1	441	Chain	ID=PRO_0000087478;Note=Coiled-coil domain-containing protein 91
CCDC91	Q7Z6B0	192	218	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	218	254	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	254	285	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	367	405	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	192	218	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	218	254	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	254	285	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	367	405	210	413	Region	Note=Homodimerization
CCDC91	Q7Z6B0	192	218	130	209	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	192	218	130	209	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	218	254	249	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	254	285	249	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	367	405	249	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	218	254	249	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	254	285	249	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	367	405	249	407	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC91	Q7Z6B0	218	254	219	254	Alternative sequence	ID=VSP_013244;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CCDC91	Q7Z6B0	254	285	219	254	Alternative sequence	ID=VSP_013244;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CCDC91	Q7Z6B0	218	254	219	254	Alternative sequence	ID=VSP_013244;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CCDC91	Q7Z6B0	254	285	219	254	Alternative sequence	ID=VSP_013244;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CCDC91	Q7Z6B0	254	285	261	261	Natural variant	ID=VAR_021531;Note=M->V;Dbxref=dbSNP:rs1133028
CCDC91	Q7Z6B0	254	285	261	261	Natural variant	ID=VAR_021531;Note=M->V;Dbxref=dbSNP:rs1133028
CCDC91	Q7Z6B0	254	285	278	278	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC91	Q7Z6B0	254	285	278	278	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC91	Q7Z6B0	254	285	284	284	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC91	Q7Z6B0	254	285	284	284	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CACNG7	P62955	65	94	1	275	Chain	ID=PRO_0000164687;Note=Voltage-dependent calcium channel gamma-7 subunit
CACNG7	P62955	65	94	1	275	Chain	ID=PRO_0000164687;Note=Voltage-dependent calcium channel gamma-7 subunit
CCNE1	P24864	37	60	1	410	Chain	ID=PRO_0000080449;Note=G1/S-specific cyclin-E1
CCNE1	P24864	154	203	1	410	Chain	ID=PRO_0000080449;Note=G1/S-specific cyclin-E1
CCNE1	P24864	235	280	1	410	Chain	ID=PRO_0000080449;Note=G1/S-specific cyclin-E1
CCNE1	P24864	154	203	154	196	Alternative sequence	ID=VSP_001253;Note=In isoform E1S. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCNE1	P24864	154	203	142	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	154	203	163	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	154	203	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	154	203	188	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	235	280	223	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	235	280	237	239	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	235	280	246	257	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	235	280	265	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE1	P24864	235	280	272	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98
CCNE2	O96020	232	277	1	404	Chain	ID=PRO_0000080461;Note=G1/S-specific cyclin-E2
CCNE2	O96020	151	200	1	404	Chain	ID=PRO_0000080461;Note=G1/S-specific cyclin-E2
CCNE2	O96020	232	277	1	404	Chain	ID=PRO_0000080461;Note=G1/S-specific cyclin-E2
CCNE2	O96020	151	200	1	404	Chain	ID=PRO_0000080461;Note=G1/S-specific cyclin-E2
CCNE2	O96020	151	200	167	211	Alternative sequence	ID=VSP_001256;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9858585;Dbxref=PMID:9858585
CCNE2	O96020	151	200	167	211	Alternative sequence	ID=VSP_001256;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9858585;Dbxref=PMID:9858585
CD276	Q5ZPR3	26	139	1	28	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
CD276	Q5ZPR3	26	139	1	28	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
CD276	Q5ZPR3	26	139	29	534	Chain	ID=PRO_0000045801;Note=CD276 antigen
CD276	Q5ZPR3	26	139	29	534	Chain	ID=PRO_0000045801;Note=CD276 antigen
CD276	Q5ZPR3	139	244	29	534	Chain	ID=PRO_0000045801;Note=CD276 antigen
CD276	Q5ZPR3	139	244	29	534	Chain	ID=PRO_0000045801;Note=CD276 antigen
CD276	Q5ZPR3	456	501	29	534	Chain	ID=PRO_0000045801;Note=CD276 antigen
CD276	Q5ZPR3	515	527	29	534	Chain	ID=PRO_0000045801;Note=CD276 antigen
CD276	Q5ZPR3	26	139	29	466	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	26	139	29	466	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	139	244	29	466	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	139	244	29	466	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	456	501	29	466	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	456	501	467	487	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	456	501	488	534	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	515	527	488	534	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	26	139	29	139	Domain	Note=Ig-like V-type 1
CD276	Q5ZPR3	26	139	29	139	Domain	Note=Ig-like V-type 1
CD276	Q5ZPR3	139	244	29	139	Domain	Note=Ig-like V-type 1
CD276	Q5ZPR3	139	244	29	139	Domain	Note=Ig-like V-type 1
CD276	Q5ZPR3	139	244	145	238	Domain	Note=Ig-like C2-type 1
CD276	Q5ZPR3	139	244	145	238	Domain	Note=Ig-like C2-type 1
CD276	Q5ZPR3	139	244	243	357	Domain	Note=Ig-like V-type 2
CD276	Q5ZPR3	139	244	243	357	Domain	Note=Ig-like V-type 2
CD276	Q5ZPR3	456	501	363	456	Domain	Note=Ig-like C2-type 2
CD276	Q5ZPR3	515	527	525	525	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569
CD276	Q5ZPR3	26	139	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	26	139	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	139	244	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	139	244	189	189	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	139	244	215	215	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	139	244	215	215	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD276	Q5ZPR3	26	139	50	122	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD276	Q5ZPR3	26	139	50	122	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD276	Q5ZPR3	139	244	165	220	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD276	Q5ZPR3	139	244	165	220	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
CD276	Q5ZPR3	139	244	159	376	Alternative sequence	ID=VSP_017088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11224528,ECO:0000303|PubMed:12975309;Dbxref=PMID:11224528,PMID:12975309
CD276	Q5ZPR3	139	244	159	376	Alternative sequence	ID=VSP_017088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11224528,ECO:0000303|PubMed:12975309;Dbxref=PMID:11224528,PMID:12975309
CD276	Q5ZPR3	456	501	465	493	Alternative sequence	ID=VSP_017089;Note=In isoform 3. EALWVTVGLSVCLIALLVALAFVCWRKIK->GPASSAVPLSPAHPPHGSMCWSHWFSRGL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CD276	Q5ZPR3	456	501	494	534	Alternative sequence	ID=VSP_017090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CD276	Q5ZPR3	515	527	494	534	Alternative sequence	ID=VSP_017090;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CD276	Q5ZPR3	26	139	97	97	Natural variant	ID=VAR_049857;Note=P->L;Dbxref=dbSNP:rs7173448
CD276	Q5ZPR3	26	139	97	97	Natural variant	ID=VAR_049857;Note=P->L;Dbxref=dbSNP:rs7173448
CD276	Q5ZPR3	26	139	111	111	Natural variant	ID=VAR_049858;Note=R->S;Dbxref=dbSNP:rs7173476
CD276	Q5ZPR3	26	139	111	111	Natural variant	ID=VAR_049858;Note=R->S;Dbxref=dbSNP:rs7173476
CD276	Q5ZPR3	26	139	137	137	Natural variant	ID=VAR_049859;Note=Q->L;Dbxref=dbSNP:rs11574477
CD276	Q5ZPR3	26	139	137	137	Natural variant	ID=VAR_049859;Note=Q->L;Dbxref=dbSNP:rs11574477
CD276	Q5ZPR3	139	244	160	160	Natural variant	ID=VAR_049860;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs11574479,PMID:14702039,PMID:16303743
CD276	Q5ZPR3	139	244	160	160	Natural variant	ID=VAR_049860;Note=T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16303743;Dbxref=dbSNP:rs11574479,PMID:14702039,PMID:16303743
CD276	Q5ZPR3	456	501	473	473	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CD81	P60033	93	118	1	236	Chain	ID=PRO_0000219221;Note=CD81 antigen
CD81	P60033	118	153	1	236	Chain	ID=PRO_0000219221;Note=CD81 antigen
CD81	P60033	153	187	1	236	Chain	ID=PRO_0000219221;Note=CD81 antigen
CD81	P60033	187	216	1	236	Chain	ID=PRO_0000219221;Note=CD81 antigen
CD81	P60033	93	118	90	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD81	P60033	93	118	113	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD81	P60033	118	153	113	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD81	P60033	153	187	113	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD81	P60033	187	216	113	201	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD81	P60033	187	216	202	224	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD81	P60033	93	118	116	116	Site	Note=Important for interaction with integrin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	144	144	Site	Note=Important for interaction with integrin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	148	148	Site	Note=Important for interaction with integrin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	153	187	156	190	Disulfide bond	.
CD81	P60033	187	216	156	190	Disulfide bond	.
CD81	P60033	153	187	157	175	Disulfide bond	.
CD81	P60033	93	118	116	116	Mutagenesis	Note=Reduces binding to integrin. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	119	119	Mutagenesis	Note=No effect on integrin binding. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	121	121	Mutagenesis	Note=No effect on integrin binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	124	124	Mutagenesis	Note=No effect on integrin binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	126	126	Mutagenesis	Note=No effect on integrin binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	144	144	Mutagenesis	Note=Reduces binding to integrin%3B when associated with E-148. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	118	153	148	148	Mutagenesis	Note=Reduces binding to integrin%3B when associated with E-144. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	153	187	186	186	Mutagenesis	Note=No effect on integrin binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	153	187	187	187	Mutagenesis	Note=No effect on integrin binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	187	216	187	187	Mutagenesis	Note=No effect on integrin binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27993971;Dbxref=PMID:27993971
CD81	P60033	93	118	89	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TCX
CD81	P60033	93	118	116	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	118	153	116	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	118	153	141	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	153	187	141	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	153	187	158	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M3D
CD81	P60033	153	187	163	165	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	153	187	166	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	153	187	172	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M2C
CD81	P60033	153	187	181	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	187	216	190	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5M33
CD81	P60033	187	216	202	230	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TCX
CDC37	Q16543	201	242	1	378	Chain	ID=PRO_0000195057;Note=Hsp90 co-chaperone Cdc37
CDC37	Q16543	201	242	2	378	Chain	ID=PRO_0000423197;Note=Hsp90 co-chaperone Cdc37%2C N-terminally processed
CDC37	Q16543	201	242	203	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W0G
CDC37	Q16543	201	242	230	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W0G
CDK19	Q9BWU1	370	459	1	502	Chain	ID=PRO_0000085713;Note=Cyclin-dependent kinase 19
CDK19	Q9BWU1	171	215	1	502	Chain	ID=PRO_0000085713;Note=Cyclin-dependent kinase 19
CDK19	Q9BWU1	105	152	1	502	Chain	ID=PRO_0000085713;Note=Cyclin-dependent kinase 19
CDK19	Q9BWU1	68	105	1	502	Chain	ID=PRO_0000085713;Note=Cyclin-dependent kinase 19
CDK19	Q9BWU1	171	215	21	335	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK19	Q9BWU1	105	152	21	335	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK19	Q9BWU1	68	105	21	335	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK19	Q9BWU1	370	459	372	404	Compositional bias	Note=Gln-rich
CDK19	Q9BWU1	105	152	151	151	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
CDK19	Q9BWU1	370	459	449	449	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
CDK4	P11802	118	174	2	303	Chain	ID=PRO_0000085778;Note=Cyclin-dependent kinase 4
CDK4	P11802	118	174	6	295	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK4	P11802	118	174	140	140	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
CDK4	P11802	118	174	172	172	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:16782892,ECO:0000269|PubMed:19237555,ECO:0000269|PubMed:19237565,ECO:0000269|PubMed:19487459;Dbxref=PMID:19369195,PMID:16782892,PMID:19237555,PMID:19237565,PMID:19487459
CDK4	P11802	118	174	1	120	Alternative sequence	ID=VSP_056487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDK4	P11802	118	174	122	122	Natural variant	ID=VAR_041976;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34386532,PMID:17344846
CDK4	P11802	118	174	172	172	Mutagenesis	Note=Weak enzyme activity towards RB1%2C but no effect on binding of CCDN1 nor CCDN3. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16782892;Dbxref=PMID:16782892
CDK4	P11802	118	174	172	172	Mutagenesis	Note=Retains moderate enzyme activity. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16782892;Dbxref=PMID:16782892
CDK4	P11802	118	174	173	173	Mutagenesis	Note=No effect on in vitro phosphorylation by CDK7. Greatly reduced T-172 phosphorylation and enzyme activity. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19487459;Dbxref=PMID:19487459
CDK4	P11802	118	174	114	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W96
CDK4	P11802	118	174	143	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W96
CDK4	P11802	118	174	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W96
CDK4	P11802	118	174	150	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W9Z
CDK4	P11802	118	174	154	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W96
CDK4	P11802	118	174	162	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W96
CDK4	P11802	118	174	172	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G33
CDK1	P06493	106	163	1	297	Chain	ID=PRO_0000085724;Note=Cyclin-dependent kinase 1
CDK1	P06493	106	163	4	287	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CDK1	P06493	106	163	128	128	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
CDK1	P06493	106	163	141	141	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CDK1	P06493	106	163	161	161	Modified residue	Note=Phosphothreonine%3B by CAK;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:20360007;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:20360007
CDK1	P06493	106	163	139	139	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CDK1	P06493	106	163	107	163	Alternative sequence	ID=VSP_021375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9515786;Dbxref=PMID:9515786
CDK1	P06493	106	163	102	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CDK1	P06493	106	163	121	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CDK1	P06493	106	163	131	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CDK1	P06493	106	163	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CDK1	P06493	106	163	142	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CDK1	P06493	106	163	149	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YC6
CDK1	P06493	106	163	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LQF
CDK1	P06493	106	163	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YC6
CARM1	Q86X55	73	115	2	608	Chain	ID=PRO_0000212338;Note=Histone-arginine methyltransferase CARM1
CARM1	Q86X55	186	223	2	608	Chain	ID=PRO_0000212338;Note=Histone-arginine methyltransferase CARM1
CARM1	Q86X55	369	398	2	608	Chain	ID=PRO_0000212338;Note=Histone-arginine methyltransferase CARM1
CARM1	Q86X55	399	444	2	608	Chain	ID=PRO_0000212338;Note=Histone-arginine methyltransferase CARM1
CARM1	Q86X55	445	474	2	608	Chain	ID=PRO_0000212338;Note=Histone-arginine methyltransferase CARM1
CARM1	Q86X55	512	538	2	608	Chain	ID=PRO_0000212338;Note=Histone-arginine methyltransferase CARM1
CARM1	Q86X55	186	223	146	453	Domain	Note=SAM-dependent MTase PRMT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
CARM1	Q86X55	369	398	146	453	Domain	Note=SAM-dependent MTase PRMT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
CARM1	Q86X55	399	444	146	453	Domain	Note=SAM-dependent MTase PRMT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
CARM1	Q86X55	445	474	146	453	Domain	Note=SAM-dependent MTase PRMT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
CARM1	Q86X55	512	538	499	608	Region	Note=Transactivation domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
CARM1	Q86X55	186	223	192	192	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen
CARM1	Q86X55	186	223	214	214	Binding site	Note=S-adenosyl-L-methionine
CARM1	Q86X55	186	223	216	216	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19843527;Dbxref=PMID:19843527
CARM1	Q86X55	369	398	369	384	Alternative sequence	ID=VSP_012506;Note=In isoform 2. RIEIPFKFHMLHSGLV->SACLASPAATALCLPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CARM1	Q86X55	369	398	385	608	Alternative sequence	ID=VSP_012507;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CARM1	Q86X55	399	444	385	608	Alternative sequence	ID=VSP_012507;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CARM1	Q86X55	445	474	385	608	Alternative sequence	ID=VSP_012507;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CARM1	Q86X55	512	538	385	608	Alternative sequence	ID=VSP_012507;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CARM1	Q86X55	186	223	187	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	186	223	197	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	186	223	208	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	186	223	218	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	369	398	369	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	369	398	382	396	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	399	444	401	405	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	399	444	417	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	399	444	433	442	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	445	474	446	456	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	445	474	457	459	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARM1	Q86X55	445	474	462	468	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U4X
CARD14	Q9BXL6	281	321	1	1004	Chain	ID=PRO_0000144088;Note=Caspase recruitment domain-containing protein 14
CARD14	Q9BXL6	363	413	1	1004	Chain	ID=PRO_0000144088;Note=Caspase recruitment domain-containing protein 14
CARD14	Q9BXL6	281	321	1	1004	Chain	ID=PRO_0000144088;Note=Caspase recruitment domain-containing protein 14
CARD14	Q9BXL6	363	413	1	1004	Chain	ID=PRO_0000144088;Note=Caspase recruitment domain-containing protein 14
CARD14	Q9BXL6	363	413	409	568	Region	Note=Maintains the protein in an inactive state;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27071417;Dbxref=PMID:27071417
CARD14	Q9BXL6	363	413	409	568	Region	Note=Maintains the protein in an inactive state;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27071417;Dbxref=PMID:27071417
CARD14	Q9BXL6	281	321	128	409	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CARD14	Q9BXL6	363	413	128	409	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CARD14	Q9BXL6	281	321	128	409	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CARD14	Q9BXL6	363	413	128	409	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CARD14	Q9BXL6	281	321	285	285	Natural variant	ID=VAR_068234;Note=May be associated with susceptibility to psoriasis. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22521419;Dbxref=dbSNP:rs281875219,PMID:22521419
CARD14	Q9BXL6	281	321	285	285	Natural variant	ID=VAR_068234;Note=May be associated with susceptibility to psoriasis. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22521419;Dbxref=dbSNP:rs281875219,PMID:22521419
CAPS2	Q9BXY5	304	335	1	557	Chain	ID=PRO_0000073540;Note=Calcyphosin-2
CAPS2	Q9BXY5	279	303	1	557	Chain	ID=PRO_0000073540;Note=Calcyphosin-2
CAPS2	Q9BXY5	78	116	1	557	Chain	ID=PRO_0000073540;Note=Calcyphosin-2
CAPS2	Q9BXY5	78	116	1	232	Alternative sequence	ID=VSP_014408;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11846421,ECO:0000303|PubMed:15489334;Dbxref=PMID:11846421,PMID:15489334
CAPS2	Q9BXY5	304	335	304	335	Alternative sequence	ID=VSP_014409;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CTSS	P25774	83	133	17	114	Propeptide	ID=PRO_0000026313;Note=Activation peptide
CTSS	P25774	42	83	17	114	Propeptide	ID=PRO_0000026313;Note=Activation peptide
CTSS	P25774	133	209	115	331	Chain	ID=PRO_0000026314;Note=Cathepsin S
CTSS	P25774	83	133	115	331	Chain	ID=PRO_0000026314;Note=Cathepsin S
CTSS	P25774	133	209	139	139	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
CTSS	P25774	83	133	104	104	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CTSS	P25774	133	209	126	224	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17469812;Dbxref=PMID:17469812
CTSS	P25774	83	133	126	224	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17469812;Dbxref=PMID:17469812
CTSS	P25774	133	209	136	180	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17469812;Dbxref=PMID:17469812
CTSS	P25774	133	209	170	213	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17469812;Dbxref=PMID:17469812
CTSS	P25774	133	209	84	133	Alternative sequence	ID=VSP_042712;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CTSS	P25774	83	133	84	133	Alternative sequence	ID=VSP_042712;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CTSS	P25774	83	133	113	113	Natural variant	ID=VAR_025385;Note=R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2230061,PMID:14702039,PMID:15489334
CTSS	P25774	133	209	161	161	Natural variant	ID=VAR_025386;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1373132,ECO:0000269|PubMed:8157683;Dbxref=dbSNP:rs1059604,PMID:1373132,PMID:8157683
CTSS	P25774	83	133	92	92	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSS	P25774	83	133	92	92	Sequence conflict	Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSS	P25774	42	83	44	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0Y
CTSS	P25774	42	83	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0Y
CTSS	P25774	42	83	79	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0Y
CTSS	P25774	83	133	85	91	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0Y
CTSS	P25774	83	133	100	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C0Y
CTSS	P25774	83	133	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HH5
CTSS	P25774	133	209	139	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	164	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	173	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	179	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	185	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	198	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CTSS	P25774	133	209	201	203	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OVX
CPM	P14384	262	313	18	423	Chain	ID=PRO_0000004391;Note=Carboxypeptidase M
CPM	P14384	262	313	18	423	Chain	ID=PRO_0000004391;Note=Carboxypeptidase M
CPM	P14384	262	313	18	423	Chain	ID=PRO_0000004391;Note=Carboxypeptidase M
CPM	P14384	262	313	281	281	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	281	281	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	281	281	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Site	Note=Probable structural role;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Site	Note=Probable structural role;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Site	Note=Probable structural role;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	138	285	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1UWY,ECO:0000269|PubMed:15066430;Dbxref=PMID:15066430
CPM	P14384	262	313	138	285	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1UWY,ECO:0000269|PubMed:15066430;Dbxref=PMID:15066430
CPM	P14384	262	313	138	285	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1UWY,ECO:0000269|PubMed:15066430;Dbxref=PMID:15066430
CPM	P14384	262	313	242	284	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1UWY,ECO:0000269|PubMed:15066430;Dbxref=PMID:15066430
CPM	P14384	262	313	242	284	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1UWY,ECO:0000269|PubMed:15066430;Dbxref=PMID:15066430
CPM	P14384	262	313	242	284	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1UWY,ECO:0000269|PubMed:15066430;Dbxref=PMID:15066430
CPM	P14384	262	313	277	277	Mutagenesis	Note=5-fold decrease in substrate affinity. 22-fold decrease in specific affinity. 104-fold decrease in catalytic efficiency. Greatly reduced heat stability. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Mutagenesis	Note=5-fold decrease in substrate affinity. 22-fold decrease in specific affinity. 104-fold decrease in catalytic efficiency. Greatly reduced heat stability. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Mutagenesis	Note=5-fold decrease in substrate affinity. 22-fold decrease in specific affinity. 104-fold decrease in catalytic efficiency. Greatly reduced heat stability. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Mutagenesis	Note=2-fold decrease in substrate affinity. Small increase in specific affinity. Reduced heat stability by 50%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Mutagenesis	Note=2-fold decrease in substrate affinity. Small increase in specific affinity. Reduced heat stability by 50%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	277	277	Mutagenesis	Note=2-fold decrease in substrate affinity. Small increase in specific affinity. Reduced heat stability by 50%25. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	281	281	Mutagenesis	Note=Abolishes enzyme activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	281	281	Mutagenesis	Note=Abolishes enzyme activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	281	281	Mutagenesis	Note=Abolishes enzyme activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12457462;Dbxref=PMID:12457462
CPM	P14384	262	313	265	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	265	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	265	271	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	279	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	279	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	279	287	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	290	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	290	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	290	292	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	293	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	293	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	293	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	301	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	301	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	301	308	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	309	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	309	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
CPM	P14384	262	313	309	312	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UWY
C3orf14	Q9HBI5	59	84	1	128	Chain	ID=PRO_0000089388;Note=Uncharacterized protein C3orf14
C3orf14	Q9HBI5	59	84	1	128	Chain	ID=PRO_0000089388;Note=Uncharacterized protein C3orf14
C3orf14	Q9HBI5	59	84	1	128	Chain	ID=PRO_0000089388;Note=Uncharacterized protein C3orf14
C3orf14	Q9HBI5	59	84	1	128	Chain	ID=PRO_0000089388;Note=Uncharacterized protein C3orf14
CCDC112	Q8NEF3	361	393	1	446	Chain	ID=PRO_0000320160;Note=Coiled-coil domain-containing protein 112
CCDC112	Q8NEF3	223	361	1	446	Chain	ID=PRO_0000320160;Note=Coiled-coil domain-containing protein 112
CCDC112	Q8NEF3	361	393	1	446	Chain	ID=PRO_0000320160;Note=Coiled-coil domain-containing protein 112
CCDC112	Q8NEF3	223	361	1	446	Chain	ID=PRO_0000320160;Note=Coiled-coil domain-containing protein 112
CCDC112	Q8NEF3	361	393	219	400	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC112	Q8NEF3	223	361	219	400	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC112	Q8NEF3	361	393	219	400	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC112	Q8NEF3	223	361	219	400	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC112	Q8NEF3	223	361	341	341	Natural variant	ID=VAR_039149;Note=K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856922,PMID:15489334
CCDC112	Q8NEF3	223	361	341	341	Natural variant	ID=VAR_039149;Note=K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856922,PMID:15489334
CCDC112	Q8NEF3	223	361	354	354	Natural variant	ID=VAR_039150;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852930,PMID:15489334
CCDC112	Q8NEF3	223	361	354	354	Natural variant	ID=VAR_039150;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852930,PMID:15489334
CCDC120	Q96HB5	206	227	1	630	Chain	ID=PRO_0000254141;Note=Coiled-coil domain-containing protein 120
CCDC120	Q96HB5	206	227	1	630	Chain	ID=PRO_0000254141;Note=Coiled-coil domain-containing protein 120
CCDC181	Q5TID7	39	356	1	509	Chain	ID=PRO_0000279465;Note=Coiled-coil domain-containing protein 181
CCDC181	Q5TID7	39	356	335	375	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC181	Q5TID7	39	356	116	122	Compositional bias	Note=Poly-Glu
CCDC181	Q5TID7	39	356	172	172	Natural variant	ID=VAR_030907;Note=F->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3820059,PMID:15489334
CCDC181	Q5TID7	39	356	238	238	Natural variant	ID=VAR_056764;Note=F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs35107735
CCDC181	Q5TID7	39	356	323	323	Natural variant	ID=VAR_056765;Note=S->C;Dbxref=dbSNP:rs35287513
CCDC181	Q5TID7	39	356	310	310	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
CCDC153	Q494R4	85	116	1	210	Chain	ID=PRO_0000342650;Note=Coiled-coil domain-containing protein 153
CCDC153	Q494R4	45	85	1	210	Chain	ID=PRO_0000342650;Note=Coiled-coil domain-containing protein 153
CCDC153	Q494R4	85	116	1	210	Chain	ID=PRO_0000342650;Note=Coiled-coil domain-containing protein 153
CCDC153	Q494R4	45	85	1	210	Chain	ID=PRO_0000342650;Note=Coiled-coil domain-containing protein 153
CCDC153	Q494R4	85	116	49	161	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC153	Q494R4	45	85	49	161	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC153	Q494R4	85	116	49	161	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC153	Q494R4	45	85	49	161	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC153	Q494R4	85	116	1	86	Alternative sequence	ID=VSP_034518;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC153	Q494R4	45	85	1	86	Alternative sequence	ID=VSP_034518;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC153	Q494R4	85	116	1	86	Alternative sequence	ID=VSP_034518;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC153	Q494R4	45	85	1	86	Alternative sequence	ID=VSP_034518;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC153	Q494R4	85	116	101	101	Natural variant	ID=VAR_044322;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2301574,PMID:15489334
CCDC153	Q494R4	85	116	101	101	Natural variant	ID=VAR_044322;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2301574,PMID:15489334
CCDC15	Q0P6D6	636	677	1	951	Chain	ID=PRO_0000307715;Note=Coiled-coil domain-containing protein 15
CCDC15	Q0P6D6	677	713	1	951	Chain	ID=PRO_0000307715;Note=Coiled-coil domain-containing protein 15
CCDC15	Q0P6D6	738	769	1	951	Chain	ID=PRO_0000307715;Note=Coiled-coil domain-containing protein 15
CCDC93	Q567U6	576	614	1	631	Chain	ID=PRO_0000234604;Note=Coiled-coil domain-containing protein 93
CCDC93	Q567U6	450	471	1	631	Chain	ID=PRO_0000234604;Note=Coiled-coil domain-containing protein 93
CCDC93	Q567U6	267	296	1	631	Chain	ID=PRO_0000234604;Note=Coiled-coil domain-containing protein 93
CCDC93	Q567U6	267	296	1	430	Region	Note=Sufficient for interaction with CCDC22;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947
CCDC93	Q567U6	576	614	448	631	Region	Note=Sufficient for interaction with WASHC2C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947
CCDC93	Q567U6	450	471	448	631	Region	Note=Sufficient for interaction with WASHC2C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947
CCDC93	Q567U6	267	296	231	428	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC93	Q567U6	576	614	560	601	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC93	Q567U6	450	471	465	465	Natural variant	ID=VAR_054111;Note=Y->H;Dbxref=dbSNP:rs17047557
CCDC69	A6NI79	165	205	2	296	Chain	ID=PRO_0000328962;Note=Coiled-coil domain-containing protein 69
CCDC69	A6NI79	165	205	48	272	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC69	A6NI79	165	205	197	197	Natural variant	ID=VAR_042584;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs248427,PMID:14702039
CCDC47	Q96A33	245	279	21	483	Chain	ID=PRO_0000235797;Note=Coiled-coil domain-containing protein 47
CCDC47	Q96A33	88	124	21	483	Chain	ID=PRO_0000235797;Note=Coiled-coil domain-containing protein 47
CCDC47	Q96A33	245	279	21	483	Chain	ID=PRO_0000235797;Note=Coiled-coil domain-containing protein 47
CCDC47	Q96A33	88	124	21	483	Chain	ID=PRO_0000235797;Note=Coiled-coil domain-containing protein 47
HCCS	P53701	174	202	2	268	Chain	ID=PRO_0000121712;Note=Cytochrome c-type heme lyase
HCCS	P53701	174	202	2	268	Chain	ID=PRO_0000121712;Note=Cytochrome c-type heme lyase
HCCS	P53701	174	202	2	268	Chain	ID=PRO_0000121712;Note=Cytochrome c-type heme lyase
CD37	P11049	228	256	1	281	Chain	ID=PRO_0000219209;Note=Leukocyte antigen CD37
CD37	P11049	228	256	112	241	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD37	P11049	228	256	242	266	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD2	P06729	204	245	25	351	Chain	ID=PRO_0000014600;Note=T-cell surface antigen CD2
CD2	P06729	204	245	25	209	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD2	P06729	204	245	210	235	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD2	P06729	204	245	236	351	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD2	P06729	204	245	129	209	Domain	Note=Ig-like C2-type
CD2	P06729	204	245	217	217	Natural variant	ID=VAR_035504;Note=In a breast cancer sample%3B somatic mutation. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
CARD11	Q9BXL7	339	381	1	1154	Chain	ID=PRO_0000144086;Note=Caspase recruitment domain-containing protein 11
CARD11	Q9BXL7	339	381	130	449	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	153	168	1	797	Chain	ID=PRO_0000307230;Note=N-acetylneuraminate 9-O-acetyltransferase
CASD1	Q96PB1	281	422	1	797	Chain	ID=PRO_0000307230;Note=N-acetylneuraminate 9-O-acetyltransferase
CASD1	Q96PB1	452	492	1	797	Chain	ID=PRO_0000307230;Note=N-acetylneuraminate 9-O-acetyltransferase
CASD1	Q96PB1	605	652	1	797	Chain	ID=PRO_0000307230;Note=N-acetylneuraminate 9-O-acetyltransferase
CASD1	Q96PB1	652	678	1	797	Chain	ID=PRO_0000307230;Note=N-acetylneuraminate 9-O-acetyltransferase
CASD1	Q96PB1	153	168	40	313	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26169044;Dbxref=PMID:26169044
CASD1	Q96PB1	281	422	40	313	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26169044;Dbxref=PMID:26169044
CASD1	Q96PB1	281	422	314	334	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	281	422	335	363	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	281	422	364	384	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	281	422	385	395	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	281	422	396	416	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	281	422	417	439	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	452	492	440	460	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	452	492	461	461	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	452	492	462	482	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	452	492	483	486	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	452	492	487	507	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	605	652	569	605	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	605	652	606	626	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	605	652	627	638	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	605	652	639	659	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	652	678	639	659	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	652	678	660	671	Topological domain	Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASD1	Q96PB1	652	678	672	692	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASD1	Q96PB1	281	422	386	386	Natural variant	ID=VAR_035383;Note=R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855797,PMID:15489334
CASD1	Q96PB1	605	652	622	622	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASS4	Q9NQ75	153	187	1	786	Chain	ID=PRO_0000079425;Note=Cas scaffolding protein family member 4
CASS4	Q9NQ75	214	651	1	786	Chain	ID=PRO_0000079425;Note=Cas scaffolding protein family member 4
CASS4	Q9NQ75	214	651	274	277	Compositional bias	Note=Poly-Ser
CASS4	Q9NQ75	214	651	373	429	Compositional bias	Note=Ser-rich
CASS4	Q9NQ75	214	651	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:23186163
CASS4	Q9NQ75	214	651	305	305	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:23186163;Dbxref=PMID:18088087,PMID:23186163
CASS4	Q9NQ75	214	651	376	376	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CASS4	Q9NQ75	214	651	390	390	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CASS4	Q9NQ75	214	651	215	651	Alternative sequence	ID=VSP_003806;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CASS4	Q9NQ75	214	651	491	491	Natural variant	ID=VAR_054084;Note=R->K;Dbxref=dbSNP:rs16979936
CASS4	Q9NQ75	214	651	629	629	Natural variant	ID=VAR_054085;Note=T->N;Dbxref=dbSNP:rs6069755
CASS4	Q9NQ75	214	651	329	329	Sequence conflict	Note=Y->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASS4	Q9NQ75	214	651	350	350	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASS4	Q9NQ75	214	651	488	488	Sequence conflict	Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3972105;Dbxref=PMID:3972105
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	278	278	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	264	307	298	298	Active site	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9299326;Dbxref=PMID:9299326
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10605
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3463996;Dbxref=PMID:3463996
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1868826;Dbxref=PMID:1868826
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	264	267	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	274	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AY2
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CTSB	P07858	264	307	302	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IPP
CPB1	P15086	124	158	111	417	Chain	ID=PRO_0000004372;Note=Carboxypeptidase B
CPB1	P15086	158	192	111	417	Chain	ID=PRO_0000004372;Note=Carboxypeptidase B
CPB1	P15086	192	229	111	417	Chain	ID=PRO_0000004372;Note=Carboxypeptidase B
CPB1	P15086	124	158	111	417	Chain	ID=PRO_0000004372;Note=Carboxypeptidase B
CPB1	P15086	158	192	111	417	Chain	ID=PRO_0000004372;Note=Carboxypeptidase B
CPB1	P15086	192	229	111	417	Chain	ID=PRO_0000004372;Note=Carboxypeptidase B
CPB1	P15086	158	192	176	179	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00730
CPB1	P15086	158	192	176	179	Region	Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00730
CPB1	P15086	158	192	176	176	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12162965;Dbxref=PMID:12162965
CPB1	P15086	158	192	176	176	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12162965;Dbxref=PMID:12162965
CPB1	P15086	158	192	179	179	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12162965;Dbxref=PMID:12162965
CPB1	P15086	158	192	179	179	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12162965;Dbxref=PMID:12162965
CPB1	P15086	158	192	173	186	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12162965;Dbxref=PMID:12162965
CPB1	P15086	158	192	173	186	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12162965;Dbxref=PMID:12162965
CPB1	P15086	192	229	208	208	Natural variant	ID=VAR_048598;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9524066;Dbxref=dbSNP:rs1059502,PMID:9524066
CPB1	P15086	192	229	208	208	Natural variant	ID=VAR_048598;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9524066;Dbxref=dbSNP:rs1059502,PMID:9524066
CPB1	P15086	124	158	122	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	122	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	140	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	140	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	153	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	158	192	153	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	124	158	153	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	158	192	153	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	158	192	168	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	158	192	168	172	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	158	192	181	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	181	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	158	192	181	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	181	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	197	199	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	197	199	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	201	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	201	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	211	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	211	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	220	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CPB1	P15086	192	229	220	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1KWM
CBLN1	P23435	88	128	22	193	Chain	ID=PRO_0000274209;Note=Cerebellin-1
CBLN1	P23435	88	128	57	193	Domain	Note=C1q;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00368
CBLN1	P23435	88	128	62	193	Region	Note=Necessary for interaction with CBLN3%2C and homotrimerization;Ontology_term=ECO:0000250;evidence=ECO:0000250
CBLN1	P23435	88	128	122	147	Region	Note=Essential for interaction with GRID2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27418511;Dbxref=PMID:27418511
CBLN1	P23435	88	128	122	122	Mutagenesis	Note=Abolishes GRID2 interaction.%3B when associated with A-124 and A-147. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27418511;Dbxref=PMID:27418511
CBLN1	P23435	88	128	124	124	Mutagenesis	Note=Abolishes GRID2 interaction.%3B when associated with A-122 and A-147. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27418511;Dbxref=PMID:27418511
CBLN1	P23435	88	128	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KC5
CBLN1	P23435	88	128	99	102	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KC5
CBLN1	P23435	88	128	103	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KC5
CBLN1	P23435	88	128	107	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KC5
CBLN1	P23435	88	128	127	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KC5
CCDC77	Q9BR77	347	389	1	488	Chain	ID=PRO_0000271003;Note=Coiled-coil domain-containing protein 77
CCDC77	Q9BR77	347	389	208	488	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC68	Q9H2F9	68	115	1	335	Chain	ID=PRO_0000264611;Note=Coiled-coil domain-containing protein 68
CCDC68	Q9H2F9	68	115	1	335	Chain	ID=PRO_0000264611;Note=Coiled-coil domain-containing protein 68
CCDC68	Q9H2F9	68	115	1	335	Chain	ID=PRO_0000264611;Note=Coiled-coil domain-containing protein 68
CCDC68	Q9H2F9	68	115	101	305	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC68	Q9H2F9	68	115	101	305	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC68	Q9H2F9	68	115	101	305	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCL21	O00585	63	123	24	134	Chain	ID=PRO_0000005220;Note=C-C motif chemokine 21
CCL21	O00585	63	123	98	134	Region	Note=C-terminal basic extension
CCL21	O00585	63	123	32	75	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22221265;Dbxref=PMID:22221265
CCL21	O00585	63	123	103	122	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCL21	O00585	63	123	61	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKI
CCL21	O00585	63	123	74	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKI
CCL21	O00585	63	123	81	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKI
CD247	P20963	131	143	22	164	Chain	ID=PRO_0000016493;Note=T-cell surface glycoprotein CD3 zeta chain
CD247	P20963	131	143	52	164	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CD247	P20963	131	143	131	159	Domain	Note=ITAM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00379
CD247	P20963	131	143	142	142	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:12522270,ECO:0000244|PubMed:15144186,ECO:0000244|PubMed:15592455,ECO:0000244|PubMed:19690332;Dbxref=PMID:12522270,PMID:15144186,PMID:15592455,PMID:19690332
CATSPERD	Q86XM0	545	587	21	798	Chain	ID=PRO_0000287150;Note=Cation channel sperm-associated protein subunit delta
CATSPERD	Q86XM0	545	587	21	718	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CUBN	O60494	1656	1693	36	3623	Chain	ID=PRO_0000046073;Note=Cubilin
CUBN	O60494	294	338	36	3623	Chain	ID=PRO_0000046073;Note=Cubilin
CUBN	O60494	294	338	263	304	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CUBN	O60494	294	338	305	348	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
CUBN	O60494	1656	1693	1620	1734	Domain	Note=CUB 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
CUBN	O60494	294	338	292	303	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CUBN	O60494	1656	1693	1675	1697	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CUBN	O60494	294	338	335	335	Natural variant	ID=VAR_061154;Note=A->T;Dbxref=dbSNP:rs57335729
CUL5	Q93034	78	137	1	780	Chain	ID=PRO_0000119797;Note=Cullin-5
CUL5	Q93034	335	371	1	780	Chain	ID=PRO_0000119797;Note=Cullin-5
CUL5	Q93034	437	481	1	780	Chain	ID=PRO_0000119797;Note=Cullin-5
CUL5	Q93034	581	635	1	780	Chain	ID=PRO_0000119797;Note=Cullin-5
CUL5	Q93034	78	137	57	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	78	137	86	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	78	137	104	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	78	137	109	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	78	137	112	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	78	137	134	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	335	371	337	357	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	335	371	358	361	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	335	371	363	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JGH
CUL5	Q93034	437	481	427	438	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	437	481	439	443	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	437	481	447	463	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	437	481	470	482	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	581	635	579	585	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	581	635	590	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	581	635	597	603	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	581	635	604	606	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	581	635	616	623	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL5	Q93034	581	635	627	638	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPL
CUL2	Q13617	663	702	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	629	663	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	462	513	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	390	433	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	663	702	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	629	663	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	462	513	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	390	433	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	663	702	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	629	663	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	462	513	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	390	433	1	745	Chain	ID=PRO_0000119790;Note=Cullin-2
CUL2	Q13617	390	433	393	393	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CUL2	Q13617	390	433	393	393	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CUL2	Q13617	390	433	393	393	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CUL2	Q13617	629	663	661	661	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CUL2	Q13617	629	663	661	661	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CUL2	Q13617	629	663	661	661	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
CUL2	Q13617	663	702	689	689	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293
CUL2	Q13617	663	702	689	689	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293
CUL2	Q13617	663	702	689	689	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293
CUL2	Q13617	663	702	689	689	Mutagenesis	Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517
CUL2	Q13617	663	702	689	689	Mutagenesis	Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517
CUL2	Q13617	663	702	689	689	Mutagenesis	Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517
CUL2	Q13617	663	702	681	681	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CUL2	Q13617	663	702	681	681	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
CUL2	Q13617	663	702	681	681	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
DNAH17	Q9UFH2	3666	3723	1	4462	Chain	ID=PRO_0000323749;Note=Dynein heavy chain 17%2C axonemal
DNAH17	Q9UFH2	3455	3495	1	4462	Chain	ID=PRO_0000323749;Note=Dynein heavy chain 17%2C axonemal
DNAH17	Q9UFH2	3455	3495	3405	3632	Region	Note=AAA 5;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH17	Q9UFH2	3666	3723	865	4462	Alternative sequence	ID=VSP_032111;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNAH17	Q9UFH2	3455	3495	865	4462	Alternative sequence	ID=VSP_032111;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNAH17	Q9UFH2	3455	3495	3478	3478	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZAP2	Q15038	44	126	1	168	Chain	ID=PRO_0000079788;Note=DAZ-associated protein 2
DAZAP2	Q15038	44	126	8	134	Compositional bias	Note=Pro-rich
DAZAP2	Q15038	44	126	45	126	Alternative sequence	ID=VSP_045678;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DAZAP2	Q15038	44	126	45	76	Alternative sequence	ID=VSP_045679;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
DAZAP2	Q15038	44	126	65	86	Alternative sequence	ID=VSP_055181;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZAP2	Q15038	44	126	101	168	Alternative sequence	ID=VSP_046764;Note=In isoform 5. GSTVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW->ASTSWMPSQCCSACSHAGSQRPRNSAEGELLHGWFRWWLHHLVRNQGHLCAGKDITYLQHFSQCNCFSHINLKLQFRHMLLGCLSGAQTFRHFSNLIRNHVMVAVPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAZAP2	Q15038	44	126	102	102	Natural variant	ID=VAR_061639;Note=S->A;Dbxref=dbSNP:rs57917280
DAZAP2	Q15038	44	126	47	47	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZAP2	Q15038	44	126	90	90	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
DCAF17	Q5H9S7	394	422	1	520	Chain	ID=PRO_0000300118;Note=DDB1- and CUL4-associated factor 17
DCAF17	Q5H9S7	422	474	1	520	Chain	ID=PRO_0000300118;Note=DDB1- and CUL4-associated factor 17
DCBLD2	Q96PD2	144	190	67	775	Chain	ID=PRO_0000021078;Note=Discoidin%2C CUB and LCCL domain-containing protein 2
DCBLD2	Q96PD2	144	190	67	528	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCBLD2	Q96PD2	144	190	72	186	Domain	Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
DCBLD2	Q96PD2	144	190	187	285	Domain	Note=LCCL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00123
DCBLD2	Q96PD2	144	190	155	155	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCBLD2	Q96PD2	144	190	126	148	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DCBLD2	Q96PD2	144	190	144	144	Natural variant	ID=VAR_050944;Note=I->M;Dbxref=dbSNP:rs9838238
DCLK2	Q8N568	286	320	1	766	Chain	ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2
DCLK2	Q8N568	567	592	1	766	Chain	ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2
DCLK2	Q8N568	625	652	1	766	Chain	ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2
DCLK2	Q8N568	652	691	1	766	Chain	ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2
DCLK2	Q8N568	567	592	394	651	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DCLK2	Q8N568	625	652	394	651	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DCLK2	Q8N568	286	320	293	362	Compositional bias	Note=Ser-rich
DCLK2	Q8N568	625	652	647	647	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9
DCLK2	Q8N568	652	691	666	666	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9
DCLK2	Q8N568	567	592	583	583	Natural variant	ID=VAR_040443;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35745104,PMID:17344846
DCP2	Q8IU60	314	349	1	420	Chain	ID=PRO_0000057051;Note=m7GpppN-mRNA hydrolase
DCP2	Q8IU60	314	349	315	349	Alternative sequence	ID=VSP_012908;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DCTN4	Q9UJW0	321	357	2	460	Chain	ID=PRO_0000079823;Note=Dynactin subunit 4
DCTN4	Q9UJW0	143	179	2	460	Chain	ID=PRO_0000079823;Note=Dynactin subunit 4
DCTN4	Q9UJW0	143	179	152	172	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DCTN4	Q9UJW0	143	179	179	179	Alternative sequence	ID=VSP_041307;Note=In isoform 3. S->SQHTIHVV;Ontology_term=ECO:0000305;evidence=ECO:0000305
DCTN4	Q9UJW0	321	357	342	342	Natural variant	ID=VAR_024336;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs11954652,PMID:14702039
UROD	P06132	71	92	1	367	Chain	ID=PRO_0000187569;Note=Uroporphyrinogen decarboxylase
UROD	P06132	92	158	1	367	Chain	ID=PRO_0000187569;Note=Uroporphyrinogen decarboxylase
UROD	P06132	158	212	1	367	Chain	ID=PRO_0000187569;Note=Uroporphyrinogen decarboxylase
UROD	P06132	212	258	1	367	Chain	ID=PRO_0000187569;Note=Uroporphyrinogen decarboxylase
UROD	P06132	71	92	85	85	Binding site	Note=Substrate
UROD	P06132	71	92	86	86	Binding site	Note=Substrate
UROD	P06132	158	212	164	164	Binding site	Note=Substrate
UROD	P06132	212	258	219	219	Binding site	Note=Substrate
UROD	P06132	71	92	86	86	Site	Note=Transition state stabilizer
UROD	P06132	71	92	77	77	Natural variant	ID=VAR_067457;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8644733,ECO:0000269|Ref.4,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1131147,PMID:8644733
UROD	P06132	71	92	80	80	Natural variant	ID=VAR_007910;Note=In HEP. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8896428;Dbxref=dbSNP:rs776907084,PMID:8896428
UROD	P06132	71	92	80	80	Natural variant	ID=VAR_022569;Note=In FPCT%3B decrease of activity. A->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11069625,ECO:0000269|PubMed:11719352;Dbxref=dbSNP:rs376921379,PMID:11069625,PMID:11719352
UROD	P06132	92	158	106	106	Natural variant	ID=VAR_060684;Note=P->L;Dbxref=dbSNP:rs11541962
UROD	P06132	92	158	113	113	Natural variant	ID=VAR_060685;Note=R->T;Dbxref=dbSNP:rs11541963
UROD	P06132	92	158	134	134	Natural variant	ID=VAR_009104;Note=In FPCT and HEP%3B requires 2 nucleotide substitutions%3B nearly normal activity. V->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10338097,ECO:0000269|PubMed:11069625,ECO:0000269|PubMed:11719352,ECO:0000269|PubMed:8176248;Dbxref=PMID:10338097,PMID:11069625,PMID:11719352,PMID:8176248
UROD	P06132	92	158	142	142	Natural variant	ID=VAR_010985;Note=In FPCT. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11295834;Dbxref=dbSNP:rs1182234844,PMID:11295834
UROD	P06132	92	158	144	144	Natural variant	ID=VAR_022570;Note=In FPCT%3B decrease of activity. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11069625;Dbxref=PMID:11069625
UROD	P06132	92	158	156	156	Natural variant	ID=VAR_022571;Note=In FPCT%3B decrease of activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11719352;Dbxref=dbSNP:rs762617943,PMID:11719352
UROD	P06132	158	212	161	161	Natural variant	ID=VAR_010986;Note=In FPCT. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11295834;Dbxref=PMID:11295834
UROD	P06132	158	212	165	165	Natural variant	ID=VAR_007911;Note=In FPCT%3B activity < 2%25. M->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11719352,ECO:0000269|PubMed:9792863;Dbxref=dbSNP:rs121918063,PMID:11719352,PMID:9792863
UROD	P06132	158	212	167	167	Natural variant	ID=VAR_007714;Note=In HEP and FPCT%3B nearly normal activity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11719352,ECO:0000269|PubMed:1905636;Dbxref=dbSNP:rs121918058,PMID:11719352,PMID:1905636
UROD	P06132	158	212	168	168	Natural variant	ID=VAR_065558;Note=In HEP%3B relative activity of 65%25 of wild-type towards uroporphyrinogen III. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17240319;Dbxref=PMID:17240319
UROD	P06132	158	212	170	170	Natural variant	ID=VAR_065559;Note=In HEP%3B relative activity of 17%25 and 60%25 of wild-type towards uroporphyrinogen I and III respectively. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21668429;Dbxref=PMID:21668429
UROD	P06132	158	212	193	193	Natural variant	ID=VAR_022572;Note=In FPCT%3B insoluble protein. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11719352;Dbxref=dbSNP:rs143823335,PMID:11719352
UROD	P06132	158	212	195	195	Natural variant	ID=VAR_007912;Note=In FPCT. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9792863;Dbxref=dbSNP:rs121918064,PMID:9792863
UROD	P06132	212	258	216	216	Natural variant	ID=VAR_022573;Note=In FPCT. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11069625;Dbxref=PMID:11069625
UROD	P06132	212	258	218	218	Natural variant	ID=VAR_022574;Note=In FPCT%3B significant decrease of activity. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11069625;Dbxref=PMID:11069625
UROD	P06132	212	258	219	219	Natural variant	ID=VAR_010987;Note=In FPCT. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11295834;Dbxref=dbSNP:rs982293378,PMID:11295834
UROD	P06132	212	258	220	220	Natural variant	ID=VAR_009105;Note=In HEP%3B mild form. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8176248;Dbxref=PMID:8176248
UROD	P06132	212	258	229	229	Natural variant	ID=VAR_009106;Note=In FPCT. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10477430;Dbxref=PMID:10477430
UROD	P06132	212	258	232	232	Natural variant	ID=VAR_022575;Note=In FPCT%3B decrease of activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11719352;Dbxref=PMID:11719352
UROD	P06132	212	258	235	235	Natural variant	ID=VAR_010988;Note=In FPCT. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11295834;Dbxref=dbSNP:rs141312224,PMID:11295834
UROD	P06132	212	258	253	253	Natural variant	ID=VAR_007913;Note=In FPCT%3B decrease of activity. L->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11719352,ECO:0000269|PubMed:8896428;Dbxref=dbSNP:rs36033115,PMID:11719352,PMID:8896428
UROD	P06132	71	92	86	86	Mutagenesis	Note=5-10%25 of wild-type activity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14633982;Dbxref=PMID:14633982
UROD	P06132	71	92	86	86	Mutagenesis	Note=Very low activity. Binds substrate with similar geometry as wild-type. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14633982;Dbxref=PMID:14633982
UROD	P06132	71	92	86	86	Mutagenesis	Note=No activity. Unable to bind substrate. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14633982;Dbxref=PMID:14633982
UROD	P06132	158	212	164	164	Mutagenesis	Note=25-30%25 of wild-type activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14633982;Dbxref=PMID:14633982
UROD	P06132	92	158	103	103	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROD	P06132	92	158	103	103	Sequence conflict	Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROD	P06132	92	158	120	120	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROD	P06132	92	158	120	120	Sequence conflict	Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROD	P06132	158	212	212	214	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROD	P06132	212	258	212	214	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
UROD	P06132	71	92	62	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	71	92	89	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	89	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	99	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	102	104	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	105	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	115	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	124	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	127	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	132	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	151	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	92	158	158	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	158	212	158	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	158	212	175	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	158	212	185	208	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	158	212	212	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	212	258	212	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	212	258	221	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	212	258	226	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	212	258	234	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
UROD	P06132	212	258	258	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1R3S
DDHD1	Q8NEL9	812	840	1	900	Chain	ID=PRO_0000079845;Note=Phospholipase DDHD1
DDHD1	Q8NEL9	614	664	1	900	Chain	ID=PRO_0000079845;Note=Phospholipase DDHD1
DDHD1	Q8NEL9	337	380	1	900	Chain	ID=PRO_0000079845;Note=Phospholipase DDHD1
DDHD1	Q8NEL9	812	840	611	886	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
DDHD1	Q8NEL9	614	664	611	886	Domain	Note=DDHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00378
DDHD1	Q8NEL9	337	380	1	418	Alternative sequence	ID=VSP_008628;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:14702039;Dbxref=PMID:11214970,PMID:14702039
DDHD1	Q8NEL9	337	380	337	337	Alternative sequence	ID=VSP_045340;Note=In isoform 4. D->DGSGINYS;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDHD1	Q8NEL9	812	840	813	841	Alternative sequence	ID=VSP_008629;Note=In isoform 2%2C isoform 3 and isoform 4. YFRLQESFFNLPQLLFPENVMQNKDNALV->L;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:14702039,PMID:15489334
DDHD1	Q8NEL9	614	664	662	662	Mutagenesis	Note=Markedly decreased enzymatic activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22922100;Dbxref=PMID:22922100
DFFB	O76075	80	143	1	338	Chain	ID=PRO_0000144713;Note=DNA fragmentation factor subunit beta
DFFB	O76075	170	227	1	338	Chain	ID=PRO_0000144713;Note=DNA fragmentation factor subunit beta
DFFB	O76075	80	143	4	80	Domain	Note=CIDE-N;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00447
DFFB	O76075	80	143	81	116	Alternative sequence	ID=VSP_001081;Note=In isoform Gamma. YVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQ->SVGVRARTKTRDTSSLSPGDCQALGNGGRCGQRLFL;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DFFB	O76075	80	143	81	103	Alternative sequence	ID=VSP_001083;Note=In isoform Delta. YVSDIRRFLSAFHEPQVGLIQAA->WFCHVSQDSLTLLGSSCPPALVS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DFFB	O76075	80	143	104	338	Alternative sequence	ID=VSP_001084;Note=In isoform Delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DFFB	O76075	170	227	104	338	Alternative sequence	ID=VSP_001084;Note=In isoform Delta. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DFFB	O76075	80	143	117	338	Alternative sequence	ID=VSP_001082;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DFFB	O76075	170	227	117	338	Alternative sequence	ID=VSP_001082;Note=In isoform Gamma. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DFFB	O76075	170	227	196	196	Natural variant	ID=VAR_009305;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10830907;Dbxref=dbSNP:rs12738235,PMID:10830907
CUTA	O60888	86	105	33	179	Chain	ID=PRO_0000006379;Note=Protein CutA
CUTA	O60888	86	105	78	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZFH
CUTA	O60888	86	105	95	109	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZFH
CUTC	Q9NTM9	20	44	1	273	Chain	ID=PRO_0000215088;Note=Copper homeostasis protein cutC homolog
CUTC	Q9NTM9	44	64	1	273	Chain	ID=PRO_0000215088;Note=Copper homeostasis protein cutC homolog
CUTC	Q9NTM9	20	44	31	31	Mutagenesis	Note=Reduces copper binding. Reduces copper binding by 75%25%3B when associated with A-52. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19878721;Dbxref=PMID:19878721
CUTC	Q9NTM9	44	64	52	52	Mutagenesis	Note=Reduces copper binding. Reduces copper binding by 75%25%3B when associated with A-31. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19878721;Dbxref=PMID:19878721
CUTC	Q9NTM9	20	44	26	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IWP
CUTC	Q9NTM9	20	44	35	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IWP
CUTC	Q9NTM9	44	64	35	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IWP
CUTC	Q9NTM9	44	64	47	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IWP
CUTC	Q9NTM9	44	64	55	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IWP
CUTC	Q9NTM9	44	64	64	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IWP
CXCL16	Q9H2A7	119	258	30	254	Chain	ID=PRO_0000005118;Note=C-X-C motif chemokine 16
CXCL16	Q9H2A7	119	258	30	254	Chain	ID=PRO_0000005118;Note=C-X-C motif chemokine 16
CXCL16	Q9H2A7	119	258	30	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	30	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	206	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	206	226	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	227	254	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	227	254	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	168	168	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	168	168	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CXCL16	Q9H2A7	119	258	123	123	Natural variant	ID=VAR_015424;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11017100,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=PMID:11017100,PMID:14702039,PMID:15489334
CXCL16	Q9H2A7	119	258	123	123	Natural variant	ID=VAR_015424;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11017100,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=PMID:11017100,PMID:14702039,PMID:15489334
CXCL16	Q9H2A7	119	258	181	181	Natural variant	ID=VAR_015425;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11017100,ECO:0000269|PubMed:11290797,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2277680,PMID:11017100,PMID:11290797,PMID:14702039,PMID:15489334
CXCL16	Q9H2A7	119	258	181	181	Natural variant	ID=VAR_015425;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11017100,ECO:0000269|PubMed:11290797,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2277680,PMID:11017100,PMID:11290797,PMID:14702039,PMID:15489334
CXCL16	Q9H2A7	119	258	135	135	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CXCL16	Q9H2A7	119	258	135	135	Sequence conflict	Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
CXCL16	Q9H2A7	119	258	143	143	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CXCL16	Q9H2A7	119	258	143	143	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CXCL16	Q9H2A7	119	258	222	222	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CXCL16	Q9H2A7	119	258	222	222	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYR61	O00622	92	211	25	381	Chain	ID=PRO_0000014398;Note=Protein CYR61
CYR61	O00622	92	211	25	94	Domain	Note=IGFBP N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00653
CYR61	O00622	92	211	98	164	Domain	Note=VWFC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
CYR61	O00622	92	211	188	188	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
CYR61	O00622	92	211	165	165	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
CYR61	O00622	92	211	210	210	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
DYNC1LI2	O43237	420	459	1	492	Chain	ID=PRO_0000114670;Note=Cytoplasmic dynein 1 light intermediate chain 2
DYNC1LI2	O43237	367	381	1	492	Chain	ID=PRO_0000114670;Note=Cytoplasmic dynein 1 light intermediate chain 2
DYNC1LI2	O43237	99	176	1	492	Chain	ID=PRO_0000114670;Note=Cytoplasmic dynein 1 light intermediate chain 2
DYNC1LI2	O43237	60	99	1	492	Chain	ID=PRO_0000114670;Note=Cytoplasmic dynein 1 light intermediate chain 2
DYNC1LI2	O43237	60	99	61	68	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
DYNC1LI2	O43237	420	459	441	441	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
DYNC1LI2	O43237	420	459	443	443	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
DYNC1LI2	O43237	420	459	446	446	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:20068231,PMID:23186163
DYNC1LI2	O43237	99	176	100	177	Alternative sequence	ID=VSP_054663;Note=In isoform 2. DHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKF->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DYNC1LI2	O43237	420	459	458	458	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
DYNC1LI2	O43237	60	99	55	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	60	99	67	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	60	99	83	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	60	99	89	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	60	99	96	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	102	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	116	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	125	127	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	128	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	139	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	142	163	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	164	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	99	176	169	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DYNC1LI2	O43237	367	381	362	370	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F1Y
DCAF6	Q58WW2	53	84	1	860	Chain	ID=PRO_0000304401;Note=DDB1- and CUL4-associated factor 6
DCAF6	Q58WW2	146	184	1	860	Chain	ID=PRO_0000304401;Note=DDB1- and CUL4-associated factor 6
DCAF6	Q58WW2	332	372	1	860	Chain	ID=PRO_0000304401;Note=DDB1- and CUL4-associated factor 6
DCAF6	Q58WW2	537	566	1	860	Chain	ID=PRO_0000304401;Note=DDB1- and CUL4-associated factor 6
DCAF6	Q58WW2	53	84	49	88	Repeat	Note=WD 1
DCAF6	Q58WW2	146	184	139	179	Repeat	Note=WD 3
DCAF6	Q58WW2	332	372	336	336	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
DCAF6	Q58WW2	53	84	54	84	Alternative sequence	ID=VSP_043312;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DCAF6	Q58WW2	537	566	547	547	Natural variant	ID=VAR_035020;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11558511,PMID:15489334
CTNNB1	P35222	561	601	2	781	Chain	ID=PRO_0000064271;Note=Catenin beta-1
CTNNB1	P35222	561	601	2	781	Chain	ID=PRO_0000064271;Note=Catenin beta-1
CTNNB1	P35222	561	601	2	781	Chain	ID=PRO_0000064271;Note=Catenin beta-1
CTNNB1	P35222	561	601	2	781	Chain	ID=PRO_0000064271;Note=Catenin beta-1
CTNNB1	P35222	561	601	531	571	Repeat	Note=ARM 10
CTNNB1	P35222	561	601	531	571	Repeat	Note=ARM 10
CTNNB1	P35222	561	601	531	571	Repeat	Note=ARM 10
CTNNB1	P35222	561	601	531	571	Repeat	Note=ARM 10
CTNNB1	P35222	561	601	594	636	Repeat	Note=ARM 11
CTNNB1	P35222	561	601	594	636	Repeat	Note=ARM 11
CTNNB1	P35222	561	601	594	636	Repeat	Note=ARM 11
CTNNB1	P35222	561	601	594	636	Repeat	Note=ARM 11
CTNNB1	P35222	561	601	558	781	Natural variant	ID=VAR_079199;Note=In MRD19%3B the patient also manifest features of exudative vitreoretinopathy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28514307;Dbxref=PMID:28514307
CTNNB1	P35222	561	601	558	781	Natural variant	ID=VAR_079199;Note=In MRD19%3B the patient also manifest features of exudative vitreoretinopathy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28514307;Dbxref=PMID:28514307
CTNNB1	P35222	561	601	558	781	Natural variant	ID=VAR_079199;Note=In MRD19%3B the patient also manifest features of exudative vitreoretinopathy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28514307;Dbxref=PMID:28514307
CTNNB1	P35222	561	601	558	781	Natural variant	ID=VAR_079199;Note=In MRD19%3B the patient also manifest features of exudative vitreoretinopathy. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28514307;Dbxref=PMID:28514307
CTNNB1	P35222	561	601	561	563	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T08
CTNNB1	P35222	561	601	561	563	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T08
CTNNB1	P35222	561	601	561	563	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T08
CTNNB1	P35222	561	601	561	563	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1T08
CTNNB1	P35222	561	601	566	580	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	566	580	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	566	580	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	566	580	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	584	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	584	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	584	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	584	592	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	596	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	596	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	596	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
CTNNB1	P35222	561	601	596	601	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDH
C21orf58	P58505	148	203	1	322	Chain	ID=PRO_0000079521;Note=Uncharacterized protein C21orf58
C21orf58	P58505	148	203	1	148	Alternative sequence	ID=VSP_057984;Note=In isoform 3. MARSRLPATSLRKPWKLDRQKLPSPDSGHSLLCGWSPGGKARPAGNTGAWAPAEQFFPASNRTREGGGLWPPLPLQSSPAAPTMLDSSAAEQVTRLTLKLLGQKLEQERQNVEGGPEGLHLEPGNEDRPDDALQTALKRRRDLLQRLR->MAILPGEAPVPGPGWPEPDAGGASVALGLPVPVCSSSASALQ
CUL3	Q13618	569	614	2	768	Chain	ID=PRO_0000119793;Note=Cullin-3
CUL3	Q13618	402	459	2	768	Chain	ID=PRO_0000119793;Note=Cullin-3
CUL3	Q13618	88	126	2	768	Chain	ID=PRO_0000119793;Note=Cullin-3
CUL3	Q13618	569	614	585	585	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
CUL3	Q13618	88	126	23	88	Alternative sequence	ID=VSP_008825;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
CUL3	Q13618	402	459	413	413	Natural variant	ID=VAR_067532;Note=In PHA2E. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22266938;Dbxref=dbSNP:rs199469656,PMID:22266938
CUL3	Q13618	402	459	459	459	Natural variant	ID=VAR_067533;Note=In PHA2E. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22266938;Dbxref=dbSNP:rs199469658,PMID:22266938
CUL3	Q13618	569	614	609	609	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
CUL3	Q13618	88	126	89	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EOZ
CUL3	Q13618	88	126	95	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EOZ
CUL3	Q13618	88	126	101	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EOZ
CUL3	Q13618	88	126	124	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EOZ
CXorf65	A6NEN9	83	106	1	183	Chain	ID=PRO_0000346434;Note=Uncharacterized protein CXorf65
DNAH11	Q96DT5	475	531	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	531	570	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	1365	1418	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	1500	1575	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	1648	1698	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	1698	1776	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	1975	2013	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	2156	2182	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	2638	2718	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	2718	2772	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	3247	3308	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	3989	4065	1	4516	Chain	ID=PRO_0000114633;Note=Dynein heavy chain 11%2C axonemal
DNAH11	Q96DT5	2156	2182	2174	2181	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAH11	Q96DT5	475	531	1	1854	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	531	570	1	1854	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	1365	1418	1	1854	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	1500	1575	1	1854	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	1648	1698	1	1854	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	1698	1776	1	1854	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	1975	2013	1855	2076	Region	Note=AAA 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	2156	2182	2136	2366	Region	Note=AAA 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	2638	2718	2472	2719	Region	Note=AAA 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	2718	2772	2472	2719	Region	Note=AAA 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	3247	3308	3072	3403	Region	Note=Stalk;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	3989	4065	3896	4122	Region	Note=AAA 6;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH11	Q96DT5	2638	2718	2675	2675	Natural variant	ID=VAR_013858;Note=I->V;Dbxref=dbSNP:rs72657364
DAW1	Q8N136	106	146	1	415	Chain	ID=PRO_0000242654;Note=Dynein assembly factor with WDR repeat domains 1
DAW1	Q8N136	106	146	90	129	Repeat	Note=WD 1
DAW1	Q8N136	106	146	132	174	Repeat	Note=WD 2
DAW1	Q8N136	106	146	121	121	Natural variant	ID=VAR_026854;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1715828,PMID:14702039
DAW1	Q8N136	106	146	129	129	Natural variant	ID=VAR_035891;Note=In a breast cancer sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs113776284,PMID:16959974
DAW1	Q8N136	106	146	104	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NNZ
DAW1	Q8N136	106	146	116	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NNZ
DAW1	Q8N136	106	146	121	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NNZ
DAW1	Q8N136	106	146	126	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NNZ
DAW1	Q8N136	106	146	137	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NNZ
DAW1	Q8N136	106	146	144	146	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NNZ
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDAH1	O94760	199	247	2	285	Chain	ID=PRO_0000171118;Note=N(G)%2CN(G)-dimethylarginine dimethylaminohydrolase 1
DDAH1	O94760	159	199	2	285	Chain	ID=PRO_0000171118;Note=N(G)%2CN(G)-dimethylarginine dimethylaminohydrolase 1
DDAH1	O94760	159	199	173	173	Active site	Note=Proton donor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19663506;Dbxref=PMID:19663506
DDAH1	O94760	199	247	222	222	Modified residue	Note=S-nitrosocysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P56965
DDAH1	O94760	159	199	158	160	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	159	199	163	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	159	199	174	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	159	199	177	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	159	199	185	189	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	192	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	159	199	192	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	205	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I2E
DDAH1	O94760	199	247	210	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	217	220	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	223	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	228	230	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	231	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	239	241	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDAH1	O94760	199	247	243	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I4A
DDRGK1	Q96HY6	224	243	29	314	Chain	ID=PRO_0000021033;Note=DDRGK domain-containing protein 1
DDRGK1	Q96HY6	211	224	29	314	Chain	ID=PRO_0000021033;Note=DDRGK domain-containing protein 1
DDRGK1	Q96HY6	224	243	229	273	Domain	Note=PCI
DDRGK1	Q96HY6	211	224	118	216	Region	Note=Mediates interaction with TRIP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
DDRGK1	Q96HY6	224	243	216	314	Region	Note=Mediates interaction with UFL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
DDRGK1	Q96HY6	211	224	216	314	Region	Note=Mediates interaction with UFL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
DDRGK1	Q96HY6	224	243	224	224	Mutagenesis	Note=Weak or no effect on ufmylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20018847;Dbxref=PMID:20018847
DDRGK1	Q96HY6	211	224	224	224	Mutagenesis	Note=Weak or no effect on ufmylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20018847;Dbxref=PMID:20018847
DDRGK1	Q96HY6	224	243	227	227	Mutagenesis	Note=Weak or no effect on ufmylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20018847;Dbxref=PMID:20018847
DDX23	Q9BUQ8	70	106	1	820	Chain	ID=PRO_0000055128;Note=Probable ATP-dependent RNA helicase DDX23
DDX23	Q9BUQ8	70	106	20	122	Compositional bias	Note=Arg-rich
DDX3Y	O15523	70	85	2	660	Chain	ID=PRO_0000055011;Note=ATP-dependent RNA helicase DDX3Y
DDX3Y	O15523	288	321	2	660	Chain	ID=PRO_0000055011;Note=ATP-dependent RNA helicase DDX3Y
DDX3Y	O15523	137	153	2	660	Chain	ID=PRO_0000055011;Note=ATP-dependent RNA helicase DDX3Y
DDX3Y	O15523	356	389	2	660	Chain	ID=PRO_0000055011;Note=ATP-dependent RNA helicase DDX3Y
DDX3Y	O15523	288	321	209	401	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX3Y	O15523	356	389	209	401	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX3Y	O15523	70	85	85	85	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O00571
DDX3Y	O15523	288	321	287	291	Alternative sequence	ID=VSP_055457;Note=In isoform 3. FSYRS->VKYSF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX3Y	O15523	288	321	292	660	Alternative sequence	ID=VSP_055458;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX3Y	O15523	356	389	292	660	Alternative sequence	ID=VSP_055458;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX41	Q9UJV9	410	434	1	622	Chain	ID=PRO_0000054970;Note=Probable ATP-dependent RNA helicase DDX41
DDX41	Q9UJV9	366	410	1	622	Chain	ID=PRO_0000054970;Note=Probable ATP-dependent RNA helicase DDX41
DDX41	Q9UJV9	366	410	212	396	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX41	Q9UJV9	410	434	407	567	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX41	Q9UJV9	366	410	407	567	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX41	Q9UJV9	410	434	416	416	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
DDX41	Q9UJV9	366	410	396	396	Natural variant	ID=VAR_076361;Note=In MPLPF%3B unknown pathological significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25920683;Dbxref=dbSNP:rs747072227,PMID:25920683
DDX41	Q9UJV9	366	410	370	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVR
DDX41	Q9UJV9	366	410	380	389	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVR
DDX41	Q9UJV9	366	410	394	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GVR
DDX41	Q9UJV9	410	434	408	414	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P6N
DDX41	Q9UJV9	366	410	408	414	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P6N
DDX41	Q9UJV9	410	434	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P6N
DDX41	Q9UJV9	410	434	420	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2P6N
DEDD	O75618	144	193	1	318	Chain	ID=PRO_0000191274;Note=Death effector domain-containing protein
DEDD	O75618	144	193	1	318	Chain	ID=PRO_0000191274;Note=Death effector domain-containing protein
DEDD	O75618	144	193	1	318	Chain	ID=PRO_0000191274;Note=Death effector domain-containing protein
DEDD	O75618	144	193	1	318	Chain	ID=PRO_0000191274;Note=Death effector domain-containing protein
DNAH12	Q6ZR08	2640	2686	1	3092	Chain	ID=PRO_0000370324;Note=Dynein heavy chain 12%2C axonemal
DNAH12	Q6ZR08	2640	2686	2218	2660	Region	Note=AAA 4;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH12	Q6ZR08	2640	2686	2661	2795	Region	Note=Stalk;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH12	Q6ZR08	2640	2686	458	3092	Alternative sequence	ID=VSP_039336;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAH12	Q6ZR08	2640	2686	2641	2686	Alternative sequence	ID=VSP_036924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	21	94	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	306	337	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	377	410	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	608	641	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	741	804	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	804	870	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	306	337	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	377	410	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	608	641	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	741	804	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	804	870	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	306	337	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	377	410	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	608	641	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	741	804	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	804	870	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	13	275	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DAPK1	P53355	21	94	13	275	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DAPK1	P53355	21	94	13	275	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DAPK1	P53355	377	410	378	407	Repeat	Note=ANK 1
DAPK1	P53355	377	410	378	407	Repeat	Note=ANK 1
DAPK1	P53355	377	410	378	407	Repeat	Note=ANK 1
DAPK1	P53355	608	641	609	638	Repeat	Note=ANK 8
DAPK1	P53355	608	641	609	638	Repeat	Note=ANK 8
DAPK1	P53355	608	641	609	638	Repeat	Note=ANK 8
DAPK1	P53355	741	804	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	804	870	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	741	804	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	804	870	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	741	804	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	804	870	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	21	94	19	27	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	19	27	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	19	27	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	94	96	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	94	96	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	94	96	Nucleotide binding	Note=ATP
DAPK1	P53355	306	337	267	334	Region	Note=Calmodulin-binding
DAPK1	P53355	306	337	267	334	Region	Note=Calmodulin-binding
DAPK1	P53355	306	337	267	334	Region	Note=Calmodulin-binding
DAPK1	P53355	21	94	42	42	Binding site	Note=ATP
DAPK1	P53355	21	94	42	42	Binding site	Note=ATP
DAPK1	P53355	21	94	42	42	Binding site	Note=ATP
DAPK1	P53355	306	337	308	308	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
DAPK1	P53355	306	337	308	308	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
DAPK1	P53355	306	337	308	308	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
DAPK1	P53355	306	337	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAPK1	P53355	306	337	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAPK1	P53355	306	337	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAPK1	P53355	306	337	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
DAPK1	P53355	306	337	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
DAPK1	P53355	306	337	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
DAPK1	P53355	21	94	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	306	337	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	377	410	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	21	94	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	306	337	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	377	410	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	21	94	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	306	337	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	377	410	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	742	783	Alternative sequence	ID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	742	783	Alternative sequence	ID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	742	783	Alternative sequence	ID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	805	870	Alternative sequence	ID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	804	870	805	870	Alternative sequence	ID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	804	870	805	870	Alternative sequence	ID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	608	641	622	622	Natural variant	ID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
DAPK1	P53355	608	641	622	622	Natural variant	ID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
DAPK1	P53355	608	641	622	622	Natural variant	ID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
DAPK1	P53355	21	94	42	42	Mutagenesis	Note=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
DAPK1	P53355	21	94	42	42	Mutagenesis	Note=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
DAPK1	P53355	21	94	42	42	Mutagenesis	Note=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	313	313	Mutagenesis	Note=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	313	313	Mutagenesis	Note=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	313	313	Mutagenesis	Note=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	21	94	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	23	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	23	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	23	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	33	35	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	33	35	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	33	35	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
DAPK1	P53355	21	94	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
DAPK1	P53355	21	94	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
DAPK1	P53355	21	94	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	306	337	304	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
DAPK1	P53355	306	337	304	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
DAPK1	P53355	306	337	304	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
DAZAP1	Q96EP5	79	101	1	407	Chain	ID=PRO_0000081565;Note=DAZ-associated protein 1
DAZAP1	Q96EP5	233	243	1	407	Chain	ID=PRO_0000081565;Note=DAZ-associated protein 1
DAZAP1	Q96EP5	243	290	1	407	Chain	ID=PRO_0000081565;Note=DAZ-associated protein 1
DAZAP1	Q96EP5	79	101	10	97	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
DAZAP1	Q96EP5	233	243	222	385	Compositional bias	Note=Pro-rich
DAZAP1	Q96EP5	243	290	222	385	Compositional bias	Note=Pro-rich
DAZAP1	Q96EP5	243	290	253	253	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
DAZAP1	Q96EP5	79	101	78	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DH8
DCBLD1	Q8N8Z6	108	153	35	715	Chain	ID=PRO_0000021076;Note=Discoidin%2C CUB and LCCL domain-containing protein 1
DCBLD1	Q8N8Z6	108	153	35	459	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCBLD1	Q8N8Z6	108	153	41	150	Domain	Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059
DCBLD1	Q8N8Z6	108	153	152	248	Domain	Note=LCCL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00123
DCBLD1	Q8N8Z6	108	153	124	124	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
DCBLD1	Q8N8Z6	108	153	94	112	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
DCTN3	O75935	137	157	2	186	Chain	ID=PRO_0000225603;Note=Dynactin subunit 3
DCTN3	O75935	89	117	2	186	Chain	ID=PRO_0000225603;Note=Dynactin subunit 3
DCTN3	O75935	60	89	2	186	Chain	ID=PRO_0000225603;Note=Dynactin subunit 3
DCTN3	O75935	137	157	135	157	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DCTN3	O75935	89	117	90	117	Alternative sequence	ID=VSP_051961;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DCTN3	O75935	137	157	138	186	Alternative sequence	ID=VSP_051964;Note=In isoform 2. DQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE->APWGVGVRDEAGSLVEDVGFAQFLSVLHFGPTGPVCGNH;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15164053,ECO:0000303|PubMed:15489334;Dbxref=PMID:15164053,PMID:15489334
DDI2	Q5TDH0	89	168	1	399	Chain	ID=PRO_0000287090;Note=Protein DDI1 homolog 2
DDI2	Q5TDH0	253	296	1	399	Chain	ID=PRO_0000287090;Note=Protein DDI1 homolog 2
DDI2	Q5TDH0	89	168	104	104	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DDI2	Q5TDH0	89	168	106	106	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
DDI2	Q5TDH0	89	168	121	121	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DDI2	Q5TDH0	89	168	128	128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
DDI2	Q5TDH0	89	168	150	150	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DDI2	Q5TDH0	253	296	212	399	Alternative sequence	ID=VSP_025297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DDI2	Q5TDH0	89	168	129	131	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K57
DDI2	Q5TDH0	89	168	135	144	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K57
DDI2	Q5TDH0	89	168	146	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K57
DDI2	Q5TDH0	89	168	157	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K57
DDI2	Q5TDH0	89	168	168	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K57
DDI2	Q5TDH0	253	296	259	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RGH
DDI2	Q5TDH0	253	296	262	267	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RGH
DDI2	Q5TDH0	253	296	271	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RGH
DDI2	Q5TDH0	253	296	276	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RGH
DDI2	Q5TDH0	253	296	290	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RGH
DHRS2	Q13268	106	140	24	280	Chain	ID=PRO_0000054642;Note=Dehydrogenase/reductase SDR family member 2%2C mitochondrial
DHRS7	Q9Y394	252	324	29	339	Chain	ID=PRO_0000031968;Note=Dehydrogenase/reductase SDR family member 7
DHRS7	Q9Y394	211	252	29	339	Chain	ID=PRO_0000031968;Note=Dehydrogenase/reductase SDR family member 7
DHRS7	Q9Y394	131	211	29	339	Chain	ID=PRO_0000031968;Note=Dehydrogenase/reductase SDR family member 7
DHRS7	Q9Y394	252	324	29	339	Chain	ID=PRO_0000031968;Note=Dehydrogenase/reductase SDR family member 7
DHRS7	Q9Y394	211	252	29	339	Chain	ID=PRO_0000031968;Note=Dehydrogenase/reductase SDR family member 7
DHRS7	Q9Y394	131	211	29	339	Chain	ID=PRO_0000031968;Note=Dehydrogenase/reductase SDR family member 7
DHRS7	Q9Y394	131	211	203	203	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
DHRS7	Q9Y394	131	211	203	203	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001
DHRS7	Q9Y394	131	211	190	190	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHRS7	Q9Y394	131	211	190	190	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DHRS7	Q9Y394	211	252	218	218	Natural variant	ID=VAR_052319;Note=R->Q;Dbxref=dbSNP:rs34583017
DHRS7	Q9Y394	211	252	218	218	Natural variant	ID=VAR_052319;Note=R->Q;Dbxref=dbSNP:rs34583017
DMC1	Q14565	126	140	1	340	Chain	ID=PRO_0000122918;Note=Meiotic recombination protein DMC1/LIM15 homolog
DMC1	Q14565	32	81	1	340	Chain	ID=PRO_0000122918;Note=Meiotic recombination protein DMC1/LIM15 homolog
DMC1	Q14565	126	140	126	133	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
DMC1	Q14565	32	81	37	37	Sequence conflict	Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
DMC1	Q14565	126	140	120	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HYY
DMC1	Q14565	126	140	132	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4HYY
DYDC1	Q8WWB3	83	114	1	177	Chain	ID=PRO_0000247556;Note=DPY30 domain-containing protein 1
DYDC1	Q8WWB3	49	83	1	177	Chain	ID=PRO_0000247556;Note=DPY30 domain-containing protein 1
DYDC1	Q8WWB3	83	114	1	177	Chain	ID=PRO_0000247556;Note=DPY30 domain-containing protein 1
DYDC1	Q8WWB3	49	83	1	177	Chain	ID=PRO_0000247556;Note=DPY30 domain-containing protein 1
DYDC1	Q8WWB3	83	114	1	177	Chain	ID=PRO_0000247556;Note=DPY30 domain-containing protein 1
DYDC1	Q8WWB3	49	83	1	177	Chain	ID=PRO_0000247556;Note=DPY30 domain-containing protein 1
DYDC2	Q96IM9	49	90	1	177	Chain	ID=PRO_0000247559;Note=DPY30 domain-containing protein 2
DYDC2	Q96IM9	49	90	1	177	Chain	ID=PRO_0000247559;Note=DPY30 domain-containing protein 2
DYDC2	Q96IM9	49	90	1	177	Chain	ID=PRO_0000247559;Note=DPY30 domain-containing protein 2
DYDC2	Q96IM9	49	90	1	177	Chain	ID=PRO_0000247559;Note=DPY30 domain-containing protein 2
DNAH2	Q9P225	2558	2621	1	4427	Chain	ID=PRO_0000322542;Note=Dynein heavy chain 2%2C axonemal
DNAH2	Q9P225	3061	3100	1	4427	Chain	ID=PRO_0000322542;Note=Dynein heavy chain 2%2C axonemal
DNAH2	Q9P225	2558	2621	1	4427	Chain	ID=PRO_0000322542;Note=Dynein heavy chain 2%2C axonemal
DNAH2	Q9P225	3061	3100	1	4427	Chain	ID=PRO_0000322542;Note=Dynein heavy chain 2%2C axonemal
DNAH2	Q9P225	3061	3100	3072	3105	Repeat	Note=TPR 3
DNAH2	Q9P225	3061	3100	3072	3105	Repeat	Note=TPR 3
DNAH2	Q9P225	2558	2621	2378	2625	Region	Note=AAA 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH2	Q9P225	2558	2621	2378	2625	Region	Note=AAA 3;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH2	Q9P225	3061	3100	2989	3272	Region	Note=Stalk;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH2	Q9P225	3061	3100	2989	3272	Region	Note=Stalk;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH2	Q9P225	2558	2621	791	4427	Alternative sequence	ID=VSP_031915;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNAH2	Q9P225	3061	3100	791	4427	Alternative sequence	ID=VSP_031915;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNAH2	Q9P225	2558	2621	791	4427	Alternative sequence	ID=VSP_031915;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNAH2	Q9P225	3061	3100	791	4427	Alternative sequence	ID=VSP_031915;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
DNAH2	Q9P225	3061	3100	3062	3100	Alternative sequence	ID=VSP_031916;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAH2	Q9P225	3061	3100	3062	3100	Alternative sequence	ID=VSP_031916;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DNAH5	Q8TE73	4303	4375	1	4624	Chain	ID=PRO_0000114630;Note=Dynein heavy chain 5%2C axonemal
DNAH5	Q8TE73	4235	4303	1	4624	Chain	ID=PRO_0000114630;Note=Dynein heavy chain 5%2C axonemal
DNAH5	Q8TE73	3676	3737	1	4624	Chain	ID=PRO_0000114630;Note=Dynein heavy chain 5%2C axonemal
DNAH5	Q8TE73	3240	3299	1	4624	Chain	ID=PRO_0000114630;Note=Dynein heavy chain 5%2C axonemal
DNAH5	Q8TE73	399	440	1	4624	Chain	ID=PRO_0000114630;Note=Dynein heavy chain 5%2C axonemal
DNAH5	Q8TE73	399	440	1	1941	Region	Note=Stem;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH5	Q8TE73	3240	3299	3185	3482	Region	Note=Stalk;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH5	Q8TE73	3676	3737	3567	3797	Region	Note=AAA 5;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAH5	Q8TE73	3240	3299	3195	3302	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DNAH5	Q8TE73	3676	3737	3732	3817	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
CCDC88C	Q9P219	1543	1566	1	2028	Chain	ID=PRO_0000286864;Note=Protein Daple
CCDC88C	Q9P219	1480	1543	1	2028	Chain	ID=PRO_0000286864;Note=Protein Daple
CCDC88C	Q9P219	133	161	1	2028	Chain	ID=PRO_0000286864;Note=Protein Daple
CCDC88C	Q9P219	1543	1566	1	1550	Alternative sequence	ID=VSP_052389;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CCDC88C	Q9P219	1480	1543	1	1550	Alternative sequence	ID=VSP_052389;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CCDC88C	Q9P219	133	161	1	1550	Alternative sequence	ID=VSP_052389;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
CCDC88C	Q9P219	133	161	1	1476	Alternative sequence	ID=VSP_052390;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC88C	Q9P219	1480	1543	1477	1481	Alternative sequence	ID=VSP_052391;Note=In isoform 2. SVGKG->MSVLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CCDC88C	Q9P219	1543	1566	1551	1566	Alternative sequence	ID=VSP_052392;Note=In isoform 3. LCEPSLEFEVPNHRQY->MPSSTLPGWPGSSGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
DCAF7	P61962	46	99	1	342	Chain	ID=PRO_0000051425;Note=DDB1- and CUL4-associated factor 7
DCAF7	P61962	46	99	6	52	Repeat	Note=WD 1
DCAF7	P61962	46	99	60	100	Repeat	Note=WD 2
DCAF7	P61962	46	99	47	246	Alternative sequence	ID=VSP_054015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DYNC1I1	O14576	122	141	2	645	Chain	ID=PRO_0000114652;Note=Cytoplasmic dynein 1 intermediate chain 1
DYNC1I1	O14576	340	389	2	645	Chain	ID=PRO_0000114652;Note=Cytoplasmic dynein 1 intermediate chain 1
DYNC1I1	O14576	340	389	338	378	Repeat	Note=WD 2
DYNC1I1	O14576	340	389	387	428	Repeat	Note=WD 3
DYNC1I1	O14576	122	141	2	123	Region	Note=Interaction with DCTN1;Ontology_term=ECO:0000250;evidence=ECO:0000250
DYNC1I1	O14576	122	141	123	142	Alternative sequence	ID=VSP_001333;Note=In isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334
DYNC1I1	O14576	340	389	373	373	Natural variant	ID=VAR_064709;Note=Found in a renal cell carcinoma case%3B somatic mutation. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752
HDC	P19113	347	380	1	662	Chain	ID=PRO_0000146950;Note=Histidine decarboxylase
HDC	P19113	106	147	1	662	Chain	ID=PRO_0000146950;Note=Histidine decarboxylase
HDC	P19113	68	106	1	662	Chain	ID=PRO_0000146950;Note=Histidine decarboxylase
HDC	P19113	68	106	81	81	Binding site	Note=Substrate%3B via amide nitrogen
HDC	P19113	347	380	348	380	Alternative sequence	ID=VSP_056296;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HDC	P19113	347	380	354	354	Mutagenesis	Note=Strongly decreases affinity for histidine. Strongly increases affinity for L-DOPA and confers enzyme activity toward L-DOPA. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22767596;Dbxref=PMID:22767596
HDC	P19113	106	147	118	118	Sequence conflict	Note=N->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
HDC	P19113	68	106	66	68	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	68	106	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	68	106	87	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	106	147	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	68	106	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	106	147	110	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	106	147	131	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	106	147	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	347	380	346	349	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	347	380	350	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
HDC	P19113	347	380	359	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E1O
DCUN1D4	Q92564	205	240	1	292	Chain	ID=PRO_0000129503;Note=DCN1-like protein 4
DCUN1D4	Q92564	205	240	101	287	Domain	Note=DCUN1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00574
DCUN1D4	Q92564	205	240	206	240	Alternative sequence	ID=VSP_016016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DCUN1D4	Q92564	205	240	211	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V89
DCUN1D4	Q92564	205	240	214	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V89
DCUN1D4	Q92564	205	240	226	228	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V89
DCUN1D4	Q92564	205	240	232	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V89
DCPS	Q96C86	174	212	2	337	Chain	ID=PRO_0000109794;Note=m7GpppX diphosphatase
DCPS	Q96C86	174	212	175	175	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	185	185	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	205	205	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	207	207	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	175	175	Mutagenesis	Note=Loss of decapping activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	185	185	Mutagenesis	Note=Loss of decapping activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	204	204	Mutagenesis	Note=Reduces decapping activity. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	205	205	Mutagenesis	Note=Reduces decapping activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	206	206	Mutagenesis	Note=No effect. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	207	207	Mutagenesis	Note=Reduces decapping activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	207	207	Mutagenesis	Note=No effect. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	174	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	183	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	186	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	196	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	200	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
CTCF	P49711	260	317	1	727	Chain	ID=PRO_0000047228;Note=Transcriptional repressor CTCF
CTCF	P49711	402	452	1	727	Chain	ID=PRO_0000047228;Note=Transcriptional repressor CTCF
CTCF	P49711	260	317	266	288	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
CTCF	P49711	260	317	294	316	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
CTCF	P49711	402	452	407	430	Zinc finger	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
CTCF	P49711	402	452	437	460	Zinc finger	Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
CTCF	P49711	260	317	289	289	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
CTCF	P49711	260	317	317	317	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
CTCF	P49711	402	452	402	402	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
CTCF	P49711	260	317	1	328	Alternative sequence	ID=VSP_045350;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
CTCF	P49711	260	317	19	727	Natural variant	ID=VAR_079374;Note=Found in an endometrial carcinoma sample%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319062;Dbxref=PMID:28319062
CTCF	P49711	402	452	19	727	Natural variant	ID=VAR_079374;Note=Found in an endometrial carcinoma sample%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319062;Dbxref=PMID:28319062
CTCF	P49711	260	317	278	278	Natural variant	ID=VAR_079375;Note=Found in an endometrial carcinoma sample%3B no effect on its nuclear localization%3B loss of its ability to inhibit cell proliferation%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319062;Dbxref=PMID:28319062
CTCF	P49711	402	452	448	448	Natural variant	ID=VAR_013144;Note=In a Wilms' tumor. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11782357;Dbxref=PMID:11782357
CTCF	P49711	260	317	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T0U
CTCF	P49711	260	317	302	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T0U
CTCF	P49711	260	317	306	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5T0U
CTCF	P49711	402	452	391	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	406	408	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CT1
CTCF	P49711	402	452	410	412	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	415	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	419	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	431	433	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K5L
CTCF	P49711	402	452	437	439	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	440	443	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	444	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
CTCF	P49711	402	452	449	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKQ
DNMT3A	Q9Y6K1	285	338	1	912	Chain	ID=PRO_0000088043;Note=DNA (cytosine-5)-methyltransferase 3A
DNMT3A	Q9Y6K1	285	338	1	912	Chain	ID=PRO_0000088043;Note=DNA (cytosine-5)-methyltransferase 3A
DNMT3A	Q9Y6K1	285	338	292	350	Domain	Note=PWWP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00162
DNMT3A	Q9Y6K1	285	338	292	350	Domain	Note=PWWP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00162
DNMT3A	Q9Y6K1	285	338	199	403	Region	Note=Interaction with DNMT1 and DNMT3B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12145218;Dbxref=PMID:12145218
DNMT3A	Q9Y6K1	285	338	199	403	Region	Note=Interaction with DNMT1 and DNMT3B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12145218;Dbxref=PMID:12145218
DNMT3A	Q9Y6K1	285	338	167	912	Alternative sequence	ID=VSP_040999;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNMT3A	Q9Y6K1	285	338	167	912	Alternative sequence	ID=VSP_040999;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNMT3A	Q9Y6K1	285	338	310	310	Natural variant	ID=VAR_071463;Note=In TBRS%3B somatic mutation. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24614070;Dbxref=dbSNP:rs587777508,PMID:24614070
DNMT3A	Q9Y6K1	285	338	310	310	Natural variant	ID=VAR_071463;Note=In TBRS%3B somatic mutation. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24614070;Dbxref=dbSNP:rs587777508,PMID:24614070
DNMT3A	Q9Y6K1	285	338	295	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	295	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	306	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	306	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	313	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	313	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	325	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	325	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	331	333	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	331	333	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	336	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMT3A	Q9Y6K1	285	338	336	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLR
DNMBP	Q6XZF7	1052	1095	1	1577	Chain	ID=PRO_0000079959;Note=Dynamin-binding protein
DNMBP	Q6XZF7	1052	1095	1008	1217	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00361
DSCC1	Q9BVC3	117	162	1	393	Chain	ID=PRO_0000318064;Note=Sister chromatid cohesion protein DCC1
DCTN2	Q13561	245	258	2	401	Chain	ID=PRO_0000079821;Note=Dynactin subunit 2
DCTN2	Q13561	223	245	2	401	Chain	ID=PRO_0000079821;Note=Dynactin subunit 2
DCTN2	Q13561	223	245	214	244	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
DDX19A	Q9NUU7	98	128	2	478	Chain	ID=PRO_0000055021;Note=ATP-dependent RNA helicase DDX19A
DDX19A	Q9NUU7	98	128	124	294	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX19A	Q9NUU7	98	128	2	299	Region	Note=N-terminal lobe;Ontology_term=ECO:0000250;evidence=ECO:0000250
DDX19A	Q9NUU7	98	128	91	119	Motif	Note=Q motif
DDX19A	Q9NUU7	98	128	118	118	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
DDX19A	Q9NUU7	98	128	1	98	Alternative sequence	ID=VSP_056954;Note=In isoform 2. MATDSWALAVDEQEAAVKSMTNLQIKEEKVKADTNGIIKTSTTAEKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRL->MSGTFLIR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX11	Q96FC9	131	160	1	970	Chain	ID=PRO_0000055136;Note=ATP-dependent DNA helicase DDX11
DDX11	Q96FC9	684	734	1	970	Chain	ID=PRO_0000055136;Note=ATP-dependent DNA helicase DDX11
DDX11	Q96FC9	131	160	9	445	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX11	Q96FC9	684	734	289	970	Alternative sequence	ID=VSP_016862;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
DDX11	Q96FC9	684	734	685	734	Alternative sequence	ID=VSP_016863;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8798685;Dbxref=PMID:8798685
CSNK2A2	P19784	208	242	1	350	Chain	ID=PRO_0000085891;Note=Casein kinase II subunit alpha'
CSNK2A2	P19784	143	171	1	350	Chain	ID=PRO_0000085891;Note=Casein kinase II subunit alpha'
CSNK2A2	P19784	123	143	1	350	Chain	ID=PRO_0000085891;Note=Casein kinase II subunit alpha'
CSNK2A2	P19784	106	123	1	350	Chain	ID=PRO_0000085891;Note=Casein kinase II subunit alpha'
CSNK2A2	P19784	208	242	40	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A2	P19784	143	171	40	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A2	P19784	123	143	40	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A2	P19784	106	123	40	325	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
CSNK2A2	P19784	143	171	157	157	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
CSNK2A2	P19784	106	123	105	107	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	106	123	110	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	123	143	122	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	106	123	122	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	123	143	126	128	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	143	171	131	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	123	143	131	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	143	171	160	162	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	143	171	163	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	143	171	167	170	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	143	171	171	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	208	242	213	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	208	242	231	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSNK2A2	P19784	208	242	239	250	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5YF9
CSPG5	O95196	398	460	31	566	Chain	ID=PRO_0000042151;Note=Chondroitin sulfate proteoglycan 5
CSPG5	O95196	398	460	31	423	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSPG5	O95196	398	460	424	444	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSPG5	O95196	398	460	445	566	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
CSPG5	O95196	398	460	371	413	Domain	Note=EGF-like
CSPG5	O95196	398	460	442	460	Region	Note=Interaction with GOPC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12885772;Dbxref=PMID:12885772
CSPG5	O95196	398	460	399	412	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
CSPG5	O95196	398	460	417	417	Natural variant	ID=VAR_055090;Note=T->P;Dbxref=dbSNP:rs34016925
COPS8	Q99627	110	146	2	209	Chain	ID=PRO_0000121007;Note=COP9 signalosome complex subunit 8
COPS8	Q99627	167	183	2	209	Chain	ID=PRO_0000121007;Note=COP9 signalosome complex subunit 8
COPS8	Q99627	110	146	8	179	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS8	Q99627	167	183	8	179	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
COPS8	Q99627	167	183	175	175	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:18850735;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569,PMID:18850735
CTR9	Q6PD62	247	283	1	1173	Chain	ID=PRO_0000231588;Note=RNA polymerase-associated protein CTR9 homolog
CTR9	Q6PD62	319	398	1	1173	Chain	ID=PRO_0000231588;Note=RNA polymerase-associated protein CTR9 homolog
CTR9	Q6PD62	791	814	1	1173	Chain	ID=PRO_0000231588;Note=RNA polymerase-associated protein CTR9 homolog
CTR9	Q6PD62	247	283	235	268	Repeat	Note=TPR 5
CTR9	Q6PD62	319	398	306	339	Repeat	Note=TPR 6
CTR9	Q6PD62	319	398	341	374	Repeat	Note=TPR 7
CTDSPL	O15194	78	89	1	276	Chain	ID=PRO_0000212569;Note=CTD small phosphatase-like protein
CTDSPL	O15194	142	173	1	276	Chain	ID=PRO_0000212569;Note=CTD small phosphatase-like protein
CTDSPL	O15194	142	173	102	260	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSPL	O15194	142	173	168	168	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
CTDSPL	O15194	78	89	79	89	Alternative sequence	ID=VSP_011541;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12721286,ECO:0000303|PubMed:15051889,ECO:0000303|PubMed:16533400,ECO:0000303|PubMed:9179494;Dbxref=PMID:12721286,PMID:15051889,PMID:16533400,PMID:9179494
CTDSPL	O15194	142	173	139	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HHL
CTDSPL	O15194	142	173	151	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HHL
CTDSPL	O15194	142	173	162	167	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HHL
CTDSPL	O15194	142	173	172	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HHL
CHTF18	Q8WVB6	524	557	1	975	Chain	ID=PRO_0000340081;Note=Chromosome transmission fidelity protein 18 homolog
CHTF18	Q8WVB6	650	725	1	975	Chain	ID=PRO_0000340081;Note=Chromosome transmission fidelity protein 18 homolog
CATSPERG	Q6ZRH7	378	398	36	1159	Chain	ID=PRO_0000019565;Note=Cation channel sperm-associated protein subunit gamma
CATSPERG	Q6ZRH7	398	438	36	1159	Chain	ID=PRO_0000019565;Note=Cation channel sperm-associated protein subunit gamma
CATSPERG	Q6ZRH7	698	719	36	1159	Chain	ID=PRO_0000019565;Note=Cation channel sperm-associated protein subunit gamma
CATSPERG	Q6ZRH7	945	976	36	1159	Chain	ID=PRO_0000019565;Note=Cation channel sperm-associated protein subunit gamma
CATSPERG	Q6ZRH7	1007	1037	36	1159	Chain	ID=PRO_0000019565;Note=Cation channel sperm-associated protein subunit gamma
CATSPERG	Q6ZRH7	378	398	36	1066	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CATSPERG	Q6ZRH7	398	438	36	1066	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CATSPERG	Q6ZRH7	698	719	36	1066	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CATSPERG	Q6ZRH7	945	976	36	1066	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CATSPERG	Q6ZRH7	1007	1037	36	1066	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
CATSPERG	Q6ZRH7	398	438	426	426	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
CUL7	Q14999	1154	1215	1	1698	Chain	ID=PRO_0000119802;Note=Cullin-7
CUL7	Q14999	1057	1118	1	1698	Chain	ID=PRO_0000119802;Note=Cullin-7
COX7A1	P24310	5	34	1	21	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1309697;Dbxref=PMID:1309697
COX7A1	P24310	5	34	22	79	Chain	ID=PRO_0000006149;Note=Cytochrome c oxidase subunit 7A1%2C mitochondrial
COX7A1	P24310	5	34	22	46	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250
DACH2	Q96NX9	163	175	1	599	Chain	ID=PRO_0000095599;Note=Dachshund homolog 2
DACH2	Q96NX9	163	175	1	219	Alternative sequence	ID=VSP_009492;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DACH2	Q96NX9	163	175	1	167	Alternative sequence	ID=VSP_044275;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DACH2	Q96NX9	163	175	163	175	Alternative sequence	ID=VSP_009490;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DCDC2B	A2VCK2	132	175	1	349	Chain	ID=PRO_0000305008;Note=Doublecortin domain-containing protein 2B
DCDC2B	A2VCK2	132	175	129	211	Domain	Note=Doublecortin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00072
DCAF15	Q66K64	437	480	1	600	Chain	ID=PRO_0000314485;Note=DDB1- and CUL4-associated factor 15
DCAF15	Q66K64	509	543	1	600	Chain	ID=PRO_0000314485;Note=DDB1- and CUL4-associated factor 15
DCLK1	O15075	563	588	1	740	Chain	ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1
DCLK1	O15075	563	588	390	647	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DCLK1	O15075	563	588	568	582	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ
DCLK3	Q9C098	528	584	1	648	Chain	ID=PRO_0000252254;Note=Serine/threonine-protein kinase DCLK3
DCLK3	Q9C098	528	584	356	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DCLK3	Q9C098	528	584	554	554	Natural variant	ID=VAR_040448;Note=In a lung squamous cell carcinoma sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs374711533,PMID:17344846
DCLK3	Q9C098	528	584	570	570	Natural variant	ID=VAR_040449;Note=In a renal clear cell carcinoma sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
CTNNAL1	Q9UBT7	449	480	1	734	Chain	ID=PRO_0000064268;Note=Alpha-catulin
CTNNAL1	Q9UBT7	396	449	1	734	Chain	ID=PRO_0000064268;Note=Alpha-catulin
CTNNAL1	Q9UBT7	367	396	1	734	Chain	ID=PRO_0000064268;Note=Alpha-catulin
CTNNAL1	Q9UBT7	173	213	1	734	Chain	ID=PRO_0000064268;Note=Alpha-catulin
CTNNAL1	Q9UBT7	367	396	374	374	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88327
CTNNAL1	Q9UBT7	449	480	397	480	Alternative sequence	ID=VSP_012582;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CTNNAL1	Q9UBT7	396	449	397	480	Alternative sequence	ID=VSP_012582;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CTNNAL1	Q9UBT7	173	213	203	203	Natural variant	ID=VAR_020925;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs28361118
CTNNAL1	Q9UBT7	396	449	424	424	Natural variant	ID=VAR_033845;Note=T->S;Dbxref=dbSNP:rs16913734
CTDSPL2	Q05D32	158	230	1	466	Chain	ID=PRO_0000331464;Note=CTD small phosphatase-like protein 2
CTDSPL2	Q05D32	413	445	1	466	Chain	ID=PRO_0000331464;Note=CTD small phosphatase-like protein 2
CTDSPL2	Q05D32	158	230	1	466	Chain	ID=PRO_0000331464;Note=CTD small phosphatase-like protein 2
CTDSPL2	Q05D32	413	445	1	466	Chain	ID=PRO_0000331464;Note=CTD small phosphatase-like protein 2
CTDSPL2	Q05D32	413	445	283	442	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSPL2	Q05D32	413	445	283	442	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
CTDSPL2	Q05D32	158	230	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
CTDSPL2	Q05D32	158	230	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
CTDSPL2	Q05D32	158	230	159	230	Alternative sequence	ID=VSP_033218;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CTDSPL2	Q05D32	158	230	159	230	Alternative sequence	ID=VSP_033218;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
CTDSPL2	Q05D32	158	230	228	228	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
CTDSPL2	Q05D32	158	230	228	228	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
DBR1	Q9UK59	238	265	1	544	Chain	ID=PRO_0000250358;Note=Lariat debranching enzyme
DBR1	Q9UK59	163	238	1	544	Chain	ID=PRO_0000250358;Note=Lariat debranching enzyme
DBR1	Q9UK59	107	134	1	544	Chain	ID=PRO_0000250358;Note=Lariat debranching enzyme
DBR1	Q9UK59	107	134	128	128	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DBR1	Q9UK59	163	238	1	232	Alternative sequence	ID=VSP_020631;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DBR1	Q9UK59	107	134	1	232	Alternative sequence	ID=VSP_020631;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DBR1	Q9UK59	163	238	233	237	Alternative sequence	ID=VSP_020632;Note=In isoform 2. ALMQH->MIHIV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DCAF10	Q5QP82	218	283	1	559	Chain	ID=PRO_0000306833;Note=DDB1- and CUL4-associated factor 10
DCAF10	Q5QP82	351	388	1	559	Chain	ID=PRO_0000306833;Note=DDB1- and CUL4-associated factor 10
DCAF10	Q5QP82	218	283	209	247	Repeat	Note=WD 2
DCAF10	Q5QP82	218	283	251	290	Repeat	Note=WD 3
DCAF10	Q5QP82	351	388	349	385	Compositional bias	Note=Ser-rich
DCAF10	Q5QP82	351	388	352	388	Alternative sequence	ID=VSP_028513;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ODC1	P11926	222	250	1	461	Chain	ID=PRO_0000149891;Note=Ornithine decarboxylase
ODC1	P11926	222	250	1	461	Chain	ID=PRO_0000149891;Note=Ornithine decarboxylase
ODC1	P11926	222	250	237	237	Binding site	Note=Pyridoxal phosphate%3B via amino nitrogen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2OO0,ECO:0000269|PubMed:17407445;Dbxref=PMID:17407445
ODC1	P11926	222	250	237	237	Binding site	Note=Pyridoxal phosphate%3B via amino nitrogen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2OO0,ECO:0000269|PubMed:17407445;Dbxref=PMID:17407445
ODC1	P11926	222	250	206	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	206	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	231	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	240	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	240	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	248	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
ODC1	P11926	222	250	248	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OO0
DDB1	Q16531	887	944	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	800	855	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	690	721	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	584	620	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	335	374	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	307	335	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	109	183	2	1140	Chain	ID=PRO_0000079840;Note=DNA damage-binding protein 1
DDB1	Q16531	690	721	2	768	Region	Note=Interaction with CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	584	620	2	768	Region	Note=Interaction with CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	335	374	2	768	Region	Note=Interaction with CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	307	335	2	768	Region	Note=Interaction with CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	109	183	2	768	Region	Note=Interaction with CDT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	335	374	13	356	Region	Note=WD repeat beta-propeller A
DDB1	Q16531	307	335	13	356	Region	Note=WD repeat beta-propeller A
DDB1	Q16531	109	183	13	356	Region	Note=WD repeat beta-propeller A
DDB1	Q16531	690	721	392	708	Region	Note=WD repeat beta-propeller B%3B Interaction with CUL4A
DDB1	Q16531	584	620	392	708	Region	Note=WD repeat beta-propeller B%3B Interaction with CUL4A
DDB1	Q16531	887	944	709	1043	Region	Note=WD repeat beta-propeller C
DDB1	Q16531	800	855	709	1043	Region	Note=WD repeat beta-propeller C
DDB1	Q16531	690	721	709	1043	Region	Note=WD repeat beta-propeller C
DDB1	Q16531	887	944	771	1140	Region	Note=Interaction with CDT1 and CUL4A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	800	855	771	1140	Region	Note=Interaction with CDT1 and CUL4A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15448697;Dbxref=PMID:15448697
DDB1	Q16531	690	721	71	759	Alternative sequence	ID=VSP_055540;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDB1	Q16531	584	620	71	759	Alternative sequence	ID=VSP_055540;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDB1	Q16531	335	374	71	759	Alternative sequence	ID=VSP_055540;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDB1	Q16531	307	335	71	759	Alternative sequence	ID=VSP_055540;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDB1	Q16531	109	183	71	759	Alternative sequence	ID=VSP_055540;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDB1	Q16531	307	335	316	319	Mutagenesis	Note=Impairs interaction with DDA1. YLDN->ALAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16949367;Dbxref=PMID:16949367
DDB1	Q16531	800	855	840	842	Mutagenesis	Note=Impairs interaction with AMBRA1%2C DTL%2C DET1%2C DCAF1%2C DCAF5%2C DCAF11 and DCAF8. EAE->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16949367;Dbxref=PMID:16949367
DDB1	Q16531	887	944	910	913	Mutagenesis	Note=Impairs interaction with AMBRA1%2C DTL and DCAF5. MALY->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16949367;Dbxref=PMID:16949367
DDB1	Q16531	887	944	898	899	Sequence conflict	Note=EL->DV;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDB1	Q16531	887	944	898	899	Sequence conflict	Note=EL->DV;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDB1	Q16531	109	183	121	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	109	183	128	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	109	183	139	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	109	183	146	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI4
DDB1	Q16531	109	183	155	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	109	183	164	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	109	183	177	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	307	335	296	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	307	335	312	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	307	335	318	320	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CI2
DDB1	Q16531	307	335	321	325	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	307	335	327	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	335	374	331	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	307	335	331	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	335	374	342	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I7K
DDB1	Q16531	335	374	347	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	335	374	358	365	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	335	374	369	371	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	335	374	374	379	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	584	620	583	585	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I7K
DDB1	Q16531	584	620	588	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	584	620	599	606	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	584	620	609	616	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	584	620	618	620	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	690	721	690	694	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	690	721	696	698	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E5Z
DDB1	Q16531	690	721	699	704	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	690	721	707	716	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	690	721	718	727	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	800	855	801	806	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	800	855	811	819	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	800	855	823	826	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI4
DDB1	Q16531	800	855	828	835	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	800	855	840	842	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I7N
DDB1	Q16531	800	855	846	854	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	887	893	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	895	897	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I7H
DDB1	Q16531	887	944	899	905	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	911	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	920	928	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	930	936	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	937	940	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDB1	Q16531	887	944	941	947	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EI3
DDX18	Q9NVP1	507	545	1	670	Chain	ID=PRO_0000055001;Note=ATP-dependent RNA helicase DDX18
DDX18	Q9NVP1	545	564	1	670	Chain	ID=PRO_0000055001;Note=ATP-dependent RNA helicase DDX18
DDX18	Q9NVP1	507	545	399	569	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX18	Q9NVP1	545	564	399	569	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX42	Q86XP3	282	341	1	938	Chain	ID=PRO_0000280058;Note=ATP-dependent RNA helicase DDX42
DDX42	Q86XP3	282	341	1	938	Chain	ID=PRO_0000280058;Note=ATP-dependent RNA helicase DDX42
DDX42	Q86XP3	282	341	1	938	Chain	ID=PRO_0000280058;Note=ATP-dependent RNA helicase DDX42
DDX42	Q86XP3	282	341	284	459	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX42	Q86XP3	282	341	284	459	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX42	Q86XP3	282	341	284	459	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX42	Q86XP3	282	341	297	304	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX42	Q86XP3	282	341	297	304	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX42	Q86XP3	282	341	297	304	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DERL1	Q9BUN8	169	205	2	251	Chain	ID=PRO_0000219042;Note=Derlin-1
DERL1	Q9BUN8	119	151	2	251	Chain	ID=PRO_0000219042;Note=Derlin-1
DERL1	Q9BUN8	119	151	106	126	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
DERL1	Q9BUN8	119	151	127	154	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DERL1	Q9BUN8	169	205	155	175	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
DERL1	Q9BUN8	169	205	176	251	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
DERL1	Q9BUN8	169	205	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DERL1	Q9BUN8	169	205	202	202	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
DERL1	Q9BUN8	169	205	170	189	Alternative sequence	ID=VSP_041329;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DERL1	Q9BUN8	169	205	171	171	Natural variant	ID=VAR_019516;Note=I->V;Dbxref=dbSNP:rs2272722
DERL1	Q9BUN8	169	205	180	180	Mutagenesis	Note=Reduces interaction with and proteolysis of XBP1 isoform 1. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25239945;Dbxref=PMID:25239945
DEK	P35659	349	372	2	375	Chain	ID=PRO_0000079858;Note=Protein DEK
DEK	P35659	191	254	2	375	Chain	ID=PRO_0000079858;Note=Protein DEK
DEK	P35659	48	82	2	375	Chain	ID=PRO_0000079858;Note=Protein DEK
DEK	P35659	349	372	337	351	DNA binding	.
DEK	P35659	349	372	367	371	DNA binding	.
DEK	P35659	191	254	205	221	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
DEK	P35659	48	82	30	49	Compositional bias	Note=Asp/Glu-rich (highly acidic)
DEK	P35659	191	254	228	236	Compositional bias	Note=Asp/Glu-rich (acidic)
DEK	P35659	191	254	241	254	Compositional bias	Note=Asp/Glu-rich (acidic)
DEK	P35659	48	82	51	51	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID:23186163
DEK	P35659	48	82	72	72	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DEK	P35659	191	254	199	199	Modified residue	Note=Phosphothreonine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154
DEK	P35659	191	254	201	201	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154
DEK	P35659	191	254	204	204	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154
DEK	P35659	191	254	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
DEK	P35659	191	254	227	227	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983
DEK	P35659	191	254	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569
DEK	P35659	191	254	231	231	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569
DEK	P35659	191	254	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569
DEK	P35659	191	254	243	243	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154
DEK	P35659	191	254	244	244	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154
DEK	P35659	191	254	251	251	Modified residue	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154
DEK	P35659	48	82	49	82	Alternative sequence	ID=VSP_042951;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DEK	P35659	349	372	343	353	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V
DEK	P35659	349	372	355	357	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V
DEK	P35659	349	372	361	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V
DENND2A	Q9ULE3	679	726	1	1009	Chain	ID=PRO_0000242682;Note=DENN domain-containing protein 2A
DENND2A	Q9ULE3	653	679	1	1009	Chain	ID=PRO_0000242682;Note=DENN domain-containing protein 2A
DENND2A	Q9ULE3	679	726	1	1009	Chain	ID=PRO_0000242682;Note=DENN domain-containing protein 2A
DENND2A	Q9ULE3	653	679	1	1009	Chain	ID=PRO_0000242682;Note=DENN domain-containing protein 2A
DENND2A	Q9ULE3	679	726	1	1009	Chain	ID=PRO_0000242682;Note=DENN domain-containing protein 2A
DENND2A	Q9ULE3	653	679	1	1009	Chain	ID=PRO_0000242682;Note=DENN domain-containing protein 2A
DENND2A	Q9ULE3	679	726	566	715	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2A	Q9ULE3	653	679	566	715	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2A	Q9ULE3	679	726	566	715	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2A	Q9ULE3	653	679	566	715	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2A	Q9ULE3	679	726	566	715	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND2A	Q9ULE3	653	679	566	715	Domain	Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND5A	Q6IQ26	761	812	1	1287	Chain	ID=PRO_0000097142;Note=DENN domain-containing protein 5A
DENND5A	Q6IQ26	717	761	1	1287	Chain	ID=PRO_0000097142;Note=DENN domain-containing protein 5A
DENND5A	Q6IQ26	379	485	1	1287	Chain	ID=PRO_0000097142;Note=DENN domain-containing protein 5A
DENND5A	Q6IQ26	379	485	278	414	Domain	Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND5A	Q6IQ26	379	485	416	598	Domain	Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304
DENND5A	Q6IQ26	761	812	787	950	Domain	Note=RUN 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00178
DEPDC1B	Q8WUY9	414	476	1	529	Chain	ID=PRO_0000284790;Note=DEP domain-containing protein 1B
DEPDC1B	Q8WUY9	252	299	1	529	Chain	ID=PRO_0000284790;Note=DEP domain-containing protein 1B
DEPDC1B	Q8WUY9	252	299	201	393	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
DEPDC1B	Q8WUY9	414	476	468	475	Compositional bias	Note=Poly-Lys
DEPDC1B	Q8WUY9	414	476	436	436	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DEPDC1B	Q8WUY9	414	476	414	475	Alternative sequence	ID=VSP_042922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DEPDC1B	Q8WUY9	252	299	272	272	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
DEPDC1B	Q8WUY9	252	299	272	272	Sequence conflict	Note=F->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
DLD	P09622	66	89	36	509	Chain	ID=PRO_0000030295;Note=Dihydrolipoyl dehydrogenase%2C mitochondrial
DLD	P09622	146	194	36	509	Chain	ID=PRO_0000030295;Note=Dihydrolipoyl dehydrogenase%2C mitochondrial
DLD	P09622	292	348	36	509	Chain	ID=PRO_0000030295;Note=Dihydrolipoyl dehydrogenase%2C mitochondrial
DLD	P09622	458	488	36	509	Chain	ID=PRO_0000030295;Note=Dihydrolipoyl dehydrogenase%2C mitochondrial
DLD	P09622	66	89	71	80	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15946682;Dbxref=PMID:15946682
DLD	P09622	146	194	183	185	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15946682;Dbxref=PMID:15946682
DLD	P09622	458	488	487	487	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09624
DLD	P09622	66	89	89	89	Binding site	Note=FAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15946682;Dbxref=PMID:15946682
DLD	P09622	146	194	154	154	Binding site	Note=FAD%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15946682;Dbxref=PMID:15946682
DLD	P09622	292	348	314	314	Binding site	Note=NAD%3B via amide nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15946682;Dbxref=PMID:15946682
DLD	P09622	458	488	473	473	Site	Note=Important for interaction with PDHX and activity of multienzyme pyruvate dehydrogenase complex;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20385101;Dbxref=PMID:20385101
DLD	P09622	66	89	66	66	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08749
DLD	P09622	66	89	66	66	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08749
DLD	P09622	146	194	159	159	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08749
DLD	P09622	146	194	166	166	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08749
DLD	P09622	292	348	297	297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6P6R2
DLD	P09622	292	348	346	346	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08749
DLD	P09622	66	89	80	85	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09624
DLD	P09622	66	89	1	99	Alternative sequence	ID=VSP_055855;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DLD	P09622	146	194	147	194	Alternative sequence	ID=VSP_055856;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DLD	P09622	66	89	72	72	Natural variant	ID=VAR_006907;Note=In DLDD%3B reduced dihydrolipoyl dehydrogenase activity%3B no effect on interaction with PDHX. K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20160912,ECO:0000269|PubMed:8506365;Dbxref=dbSNP:rs121964987,PMID:20160912,PMID:8506365
DLD	P09622	292	348	331	331	Natural variant	ID=VAR_014555;Note=L->V;Dbxref=dbSNP:rs17624
DLD	P09622	458	488	479	479	Natural variant	ID=VAR_076990;Note=In DLDD%3B reduced dehydrogenase activity%3B increased proteolytic activity. D->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10448086,ECO:0000269|PubMed:17404228;Dbxref=dbSNP:rs397514649,PMID:10448086,PMID:17404228
DLD	P09622	458	488	482	482	Natural variant	ID=VAR_076991;Note=In DLDD%3B reduced enzyme activity. R->G;Dbxref=dbSNP:rs397514650
DLD	P09622	458	488	488	488	Natural variant	ID=VAR_006908;Note=In DLDD%3B no effect on interaction with PDHX. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20160912,ECO:0000269|PubMed:8506365;Dbxref=dbSNP:rs121964988,PMID:20160912,PMID:8506365
DLD	P09622	66	89	89	89	Mutagenesis	Note=Abolishes dihydrolipoyl dehydrogenase activity. Does not affect interaction with PDHX. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20160912;Dbxref=PMID:20160912
DLD	P09622	458	488	466	466	Mutagenesis	Note=Decreases dehydrogenase activity. Loss of proteolytic activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17404228;Dbxref=PMID:17404228
DLD	P09622	458	488	473	473	Mutagenesis	Note=Reduces interaction with PDHX. Inhibits multienzyme pyruvate dehydrogenase complex activity. Does not affect dihydrolipoyl dehydrogenase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20385101;Dbxref=PMID:20385101
DLD	P09622	458	488	473	473	Mutagenesis	Note=Does not affect dihydrolipoyl dehydrogenase activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20385101;Dbxref=PMID:20385101
DLD	P09622	458	488	473	473	Mutagenesis	Note=Reduces interaction with PDHX. Inhibits multienzyme pyruvate dehydrogenase complex activity. Does not affect dihydrolipoyl dehydrogenase activity. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20385101;Dbxref=PMID:20385101
DLD	P09622	458	488	482	482	Mutagenesis	Note=Does not affect dihydrolipoyl dehydrogenase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20385101;Dbxref=PMID:20385101
DLD	P09622	458	488	482	482	Mutagenesis	Note=Does not affect interaction with PDHX. R->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20160912;Dbxref=PMID:20160912
DLD	P09622	458	488	485	485	Mutagenesis	Note=Loss of dehydrogenase activity. Increases proteolytic activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17404228;Dbxref=PMID:17404228
DLD	P09622	146	194	154	154	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
DLD	P09622	66	89	67	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	66	89	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	66	89	78	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	66	89	85	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	146	194	148	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	146	194	161	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	146	194	171	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	146	194	185	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	292	348	289	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	292	348	302	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	292	348	315	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	292	348	324	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	458	488	460	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DLD	P09622	458	488	477	482	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5Z
DNA2	P51530	899	929	1	1060	Chain	ID=PRO_0000080712;Note=DNA replication ATP-dependent helicase/nuclease DNA2
DNA2	P51530	472	548	1	1060	Chain	ID=PRO_0000080712;Note=DNA replication ATP-dependent helicase/nuclease DNA2
DNA2	P51530	407	471	1	1060	Chain	ID=PRO_0000080712;Note=DNA replication ATP-dependent helicase/nuclease DNA2
DNA2	P51530	196	239	1	1060	Chain	ID=PRO_0000080712;Note=DNA replication ATP-dependent helicase/nuclease DNA2
DNA2	P51530	472	548	81	519	Region	Note=Nuclease activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNA2	P51530	407	471	81	519	Region	Note=Nuclease activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNA2	P51530	196	239	81	519	Region	Note=Nuclease activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNA2	P51530	899	929	520	1060	Region	Note=Helicase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNA2	P51530	472	548	520	1060	Region	Note=Helicase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNA2	P51530	899	929	663	900	Alternative sequence	ID=VSP_021869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNA2	P51530	899	929	688	1060	Alternative sequence	ID=VSP_021871;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNA2	P51530	196	239	198	198	Natural variant	ID=VAR_069905;Note=In PEOA6%3B the mutant protein has a complete loss of nuclease activity and severely impaired helicase activity%3B consistent with a loss of function mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23352259;Dbxref=dbSNP:rs1272393477,PMID:23352259
DNA2	P51530	196	239	227	227	Natural variant	ID=VAR_069906;Note=In PEOA6%3B the mutant protein has significantly reduced nuclease and helicase activity%3B consistent with a loss of function mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23352259;Dbxref=dbSNP:rs760412883,PMID:23352259
AMBN	Q9NP70	28	45	27	447	Chain	ID=PRO_0000001192;Note=Ameloblastin
AMBN	Q9NP70	251	266	27	447	Chain	ID=PRO_0000001192;Note=Ameloblastin
AMBN	Q9NP70	28	45	37	37	Modified residue	Note=Hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250
AMBN	Q9NP70	28	45	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q28989
AMBN	Q9NP70	251	266	255	255	Natural variant	ID=VAR_048225;Note=A->V;Dbxref=dbSNP:rs7439186
ANKRD36	A6QL64	198	243	1	1941	Chain	ID=PRO_0000334544;Note=Ankyrin repeat domain-containing protein 36A
ANKRD36	A6QL64	1828	1879	1	1941	Chain	ID=PRO_0000334544;Note=Ankyrin repeat domain-containing protein 36A
ANKRD36	A6QL64	198	243	196	225	Repeat	Note=ANK 6
ANKRD36	A6QL64	1828	1879	1707	1932	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD36	A6QL64	198	243	1	1149	Alternative sequence	ID=VSP_039656;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.6;Dbxref=PMID:10997877,PMID:15489334
ANKRD36	A6QL64	198	243	164	1941	Alternative sequence	ID=VSP_039658;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ANKRD36	A6QL64	1828	1879	164	1941	Alternative sequence	ID=VSP_039658;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334
ANKRD36	A6QL64	198	243	171	1941	Alternative sequence	ID=VSP_039660;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD36	A6QL64	1828	1879	171	1941	Alternative sequence	ID=VSP_039660;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANAPC7	Q9UJX3	411	486	1	599	Chain	ID=PRO_0000106261;Note=Anaphase-promoting complex subunit 7
ANAPC7	Q9UJX3	411	486	407	440	Repeat	Note=TPR 6
ANAPC7	Q9UJX3	411	486	441	475	Repeat	Note=TPR 7
ANAPC7	Q9UJX3	411	486	476	508	Repeat	Note=TPR 8
ANAPC7	Q9UJX3	411	486	407	420	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC7	Q9UJX3	411	486	423	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC7	Q9UJX3	411	486	442	453	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC7	Q9UJX3	411	486	454	456	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC7	Q9UJX3	411	486	458	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC7	Q9UJX3	411	486	476	489	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
AP1AR	Q63HQ0	94	127	1	302	Chain	ID=PRO_0000089432;Note=AP-1 complex-associated regulatory protein
AP1AR	Q63HQ0	171	214	1	302	Chain	ID=PRO_0000089432;Note=AP-1 complex-associated regulatory protein
AP1AR	Q63HQ0	94	127	78	138	Region	Note=Interaction with AP1G1
AP1AR	Q63HQ0	171	214	199	215	Region	Note=Sufficient for association with the Arp2/3 complex
AP1AR	Q63HQ0	94	127	80	138	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AP1AR	Q63HQ0	94	127	94	126	Alternative sequence	ID=VSP_015339;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AP1AR	Q63HQ0	171	214	210	210	Mutagenesis	Note=Loss of association with the Arp2/3 complex and endosomal colocalization. Abolishes interaction with KLC2%2C no effect on interaction with AP1G1. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19706427,ECO:0000269|PubMed:22689987;Dbxref=PMID:19706427,PMID:22689987
APOH	P02749	261	327	20	345	Chain	ID=PRO_0000002059;Note=Beta-2-glycoprotein 1
APOH	P02749	201	261	20	345	Chain	ID=PRO_0000002059;Note=Beta-2-glycoprotein 1
APOH	P02749	138	201	20	345	Chain	ID=PRO_0000002059;Note=Beta-2-glycoprotein 1
APOH	P02749	138	201	82	139	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
APOH	P02749	201	261	140	202	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
APOH	P02749	138	201	140	202	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
APOH	P02749	261	327	203	262	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
APOH	P02749	201	261	203	262	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
APOH	P02749	261	327	263	345	Region	Note=Sushi-like
APOH	P02749	138	201	149	149	Glycosylation	Note=O-linked (GalNAc...) threonine
APOH	P02749	138	201	162	162	Glycosylation	Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:19838169,ECO:0000269|PubMed:6587378;Dbxref=PMID:14760718,PMID:15084671,PMID:16335952,PMID:16740002,PMID:19139490,PMID:19159218,PMID:19838169,PMID:6587378
APOH	P02749	138	201	183	183	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6587378;Dbxref=PMID:14760718,PMID:16335952,PMID:19159218,PMID:6587378
APOH	P02749	138	201	193	193	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6587378;Dbxref=PMID:14760718,PMID:16335952,PMID:19159218,PMID:6587378
APOH	P02749	201	261	253	253	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15084671,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:16740002,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6587378;Dbxref=PMID:15084671,PMID:16335952,PMID:16740002,PMID:19159218,PMID:6587378
APOH	P02749	138	201	142	188	Disulfide bond	.
APOH	P02749	138	201	174	200	Disulfide bond	.
APOH	P02749	201	261	205	248	Disulfide bond	.
APOH	P02749	201	261	234	260	Disulfide bond	.
APOH	P02749	261	327	264	315	Disulfide bond	.
APOH	P02749	261	327	300	325	Disulfide bond	.
APOH	P02749	261	327	307	345	Disulfide bond	.
APOH	P02749	138	201	154	154	Natural variant	ID=VAR_019155;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs8178847
APOH	P02749	261	327	266	266	Natural variant	ID=VAR_000673;Note=In 23%25 of the population. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8099061,ECO:0000269|Ref.8;Dbxref=dbSNP:rs4581,PMID:8099061
APOH	P02749	261	327	325	325	Natural variant	ID=VAR_008170;Note=Loss of phosphatidylserine-binding. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9063752;Dbxref=dbSNP:rs1801689,PMID:9063752
APOH	P02749	138	201	188	188	Sequence conflict	Note=C->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
APOH	P02749	138	201	136	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	151	155	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	169	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	178	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	184	188	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	192	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	199	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	138	201	199	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	214	217	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	222	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	238	242	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	244	248	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	252	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	261	327	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	201	261	260	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1QUB
APOH	P02749	261	327	267	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	272	275	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	278	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	282	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	286	288	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	295	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	303	306	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
APOH	P02749	261	327	307	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3OP8
ARAF	P10398	517	562	1	606	Chain	ID=PRO_0000085622;Note=Serine/threonine-protein kinase A-Raf
ARAF	P10398	517	562	310	570	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ARAF	P10398	517	562	187	606	Alternative sequence	ID=VSP_045610;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17535970,ECO:0000303|Ref.5;Dbxref=PMID:17535970
ASL	P04424	4	69	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	97	116	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	149	174	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	175	200	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	306	326	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	4	69	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	97	116	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	149	174	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	175	200	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	306	326	2	464	Chain	ID=PRO_0000137712;Note=Argininosuccinate lyase
ASL	P04424	4	69	7	7	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YI0
ASL	P04424	4	69	7	7	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91YI0
ASL	P04424	4	69	69	69	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
ASL	P04424	4	69	69	69	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20167786;Dbxref=PMID:20167786
ASL	P04424	175	200	176	201	Alternative sequence	ID=VSP_047255;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASL	P04424	175	200	176	201	Alternative sequence	ID=VSP_047255;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASL	P04424	306	326	307	326	Alternative sequence	ID=VSP_047256;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASL	P04424	306	326	307	326	Alternative sequence	ID=VSP_047256;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASL	P04424	4	69	31	31	Natural variant	ID=VAR_043106;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B no effect on protein expression. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs754995756,PMID:17326097,PMID:19703900
ASL	P04424	4	69	31	31	Natural variant	ID=VAR_043106;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B no effect on protein expression. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs754995756,PMID:17326097,PMID:19703900
ASL	P04424	97	116	104	104	Natural variant	ID=VAR_072190;Note=In ARGINSA. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	97	116	104	104	Natural variant	ID=VAR_072190;Note=In ARGINSA. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	97	116	111	111	Natural variant	ID=VAR_000677;Note=In ARGINSA. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1705937;Dbxref=dbSNP:rs138310841,PMID:1705937
ASL	P04424	97	116	111	111	Natural variant	ID=VAR_000677;Note=In ARGINSA. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1705937;Dbxref=dbSNP:rs138310841,PMID:1705937
ASL	P04424	97	116	113	113	Natural variant	ID=VAR_043107;Note=In ARGINSA%3B complete loss of argininosuccinate lyase activity%3B no effect on protein expression. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs752783461,PMID:17326097,PMID:19703900
ASL	P04424	97	116	113	113	Natural variant	ID=VAR_043107;Note=In ARGINSA%3B complete loss of argininosuccinate lyase activity%3B no effect on protein expression. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs752783461,PMID:17326097,PMID:19703900
ASL	P04424	149	174	156	156	Natural variant	ID=VAR_072195;Note=In ARGINSA. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs769017508,PMID:24166829
ASL	P04424	149	174	156	156	Natural variant	ID=VAR_072195;Note=In ARGINSA. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs769017508,PMID:24166829
ASL	P04424	149	174	160	160	Natural variant	ID=VAR_072196;Note=In ARGINSA. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	149	174	160	160	Natural variant	ID=VAR_072196;Note=In ARGINSA. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	149	174	166	166	Natural variant	ID=VAR_072197;Note=In ARGINSA. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	149	174	166	166	Natural variant	ID=VAR_072197;Note=In ARGINSA. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	149	174	168	168	Natural variant	ID=VAR_072198;Note=In ARGINSA. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs727503811,PMID:24166829
ASL	P04424	149	174	168	168	Natural variant	ID=VAR_072198;Note=In ARGINSA. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs727503811,PMID:24166829
ASL	P04424	149	174	170	170	Natural variant	ID=VAR_072199;Note=In ARGINSA. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	149	174	170	170	Natural variant	ID=VAR_072199;Note=In ARGINSA. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	175	200	178	178	Natural variant	ID=VAR_017572;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B no effect on protein expression. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12408190,ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs28941473,PMID:12408190,PMID:17326097,PMID:19703900
ASL	P04424	175	200	178	178	Natural variant	ID=VAR_017572;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B no effect on protein expression. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12408190,ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs28941473,PMID:12408190,PMID:17326097,PMID:19703900
ASL	P04424	175	200	180	180	Natural variant	ID=VAR_072200;Note=In ARGINSA. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs1057141162,PMID:24166829
ASL	P04424	175	200	180	180	Natural variant	ID=VAR_072200;Note=In ARGINSA. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs1057141162,PMID:24166829
ASL	P04424	175	200	181	181	Natural variant	ID=VAR_036281;Note=In a breast cancer sample%3B somatic mutation. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ASL	P04424	175	200	181	181	Natural variant	ID=VAR_036281;Note=In a breast cancer sample%3B somatic mutation. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ASL	P04424	175	200	182	182	Natural variant	ID=VAR_072201;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B reduces protein expression. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19703900,ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs751590073,PMID:19703900,PMID:24166829
ASL	P04424	175	200	182	182	Natural variant	ID=VAR_072201;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B reduces protein expression. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19703900,ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs751590073,PMID:19703900,PMID:24166829
ASL	P04424	175	200	186	186	Natural variant	ID=VAR_043108;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B reduces protein expression. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs752397242,PMID:17326097,PMID:19703900
ASL	P04424	175	200	186	186	Natural variant	ID=VAR_043108;Note=In ARGINSA%3B reduction of argininosuccinate lyase activity%3B reduces protein expression. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17326097,ECO:0000269|PubMed:19703900;Dbxref=dbSNP:rs752397242,PMID:17326097,PMID:19703900
ASL	P04424	175	200	191	191	Natural variant	ID=VAR_072202;Note=In ARGINSA. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs143508372,PMID:24166829
ASL	P04424	175	200	191	191	Natural variant	ID=VAR_072202;Note=In ARGINSA. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs143508372,PMID:24166829
ASL	P04424	175	200	193	193	Natural variant	ID=VAR_000678;Note=In ARGINSA. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1705937;Dbxref=dbSNP:rs373697663,PMID:1705937
ASL	P04424	175	200	193	193	Natural variant	ID=VAR_000678;Note=In ARGINSA. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1705937;Dbxref=dbSNP:rs373697663,PMID:1705937
ASL	P04424	175	200	193	193	Natural variant	ID=VAR_072203;Note=In ARGINSA. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs1428029508,PMID:24166829
ASL	P04424	175	200	193	193	Natural variant	ID=VAR_072203;Note=In ARGINSA. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs1428029508,PMID:24166829
ASL	P04424	175	200	200	200	Natural variant	ID=VAR_036282;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ASL	P04424	175	200	200	200	Natural variant	ID=VAR_036282;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ASL	P04424	306	326	306	306	Natural variant	ID=VAR_072215;Note=In ARGINSA%3B severe. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs868834862,PMID:24166829
ASL	P04424	306	326	306	306	Natural variant	ID=VAR_072215;Note=In ARGINSA%3B severe. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=dbSNP:rs868834862,PMID:24166829
ASL	P04424	306	326	324	324	Natural variant	ID=VAR_072216;Note=In ARGINSA. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	306	326	324	324	Natural variant	ID=VAR_072216;Note=In ARGINSA. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	306	326	326	326	Natural variant	ID=VAR_072217;Note=In ARGINSA%3B severe. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	306	326	326	326	Natural variant	ID=VAR_072217;Note=In ARGINSA%3B severe. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24166829;Dbxref=PMID:24166829
ASL	P04424	4	69	51	51	Mutagenesis	Note=2-fold reduction in activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1705937;Dbxref=PMID:1705937
ASL	P04424	4	69	51	51	Mutagenesis	Note=2-fold reduction in activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1705937;Dbxref=PMID:1705937
ASL	P04424	4	69	19	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	19	25	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	32	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	32	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	35	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	35	51	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	57	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	4	69	57	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	88	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	88	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	101	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	101	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	107	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	107	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	113	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	113	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	97	116	113	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	113	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	154	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	154	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	162	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	162	168	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	169	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	175	200	169	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	149	174	169	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	175	200	169	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	175	200	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	175	200	195	197	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	306	326	291	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	306	326	291	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	306	326	323	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
ASL	P04424	306	326	323	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K62
AKR7A3	O95154	134	169	1	331	Chain	ID=PRO_0000070378;Note=Aflatoxin B1 aldehyde reductase member 3
AKR7A3	O95154	134	169	143	144	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7
AKR7A3	O95154	134	169	169	169	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR7A3	O95154	134	169	138	138	Natural variant	ID=VAR_017416;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10383892,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2231198,PMID:10383892,PMID:15489334
AKR7A3	O95154	134	169	136	144	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CLP
AKR7A3	O95154	134	169	147	160	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CLP
AKR7A3	O95154	134	169	165	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CLP
ARL5A	Q9Y689	85	113	2	179	Chain	ID=PRO_0000207467;Note=ADP-ribosylation factor-like protein 5A
ARL5A	Q9Y689	85	113	86	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H17
ARL5A	Q9Y689	85	113	96	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H17
ARL5A	Q9Y689	85	113	99	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H17
ARL5A	Q9Y689	85	113	113	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2H17
ARIH2	O95376	371	419	1	493	Chain	ID=PRO_0000055755;Note=E3 ubiquitin-protein ligase ARIH2
ARIH2	O95376	442	470	1	493	Chain	ID=PRO_0000055755;Note=E3 ubiquitin-protein ligase ARIH2
ARIH2	O95376	371	419	1	493	Chain	ID=PRO_0000055755;Note=E3 ubiquitin-protein ligase ARIH2
ARIH2	O95376	442	470	1	493	Chain	ID=PRO_0000055755;Note=E3 ubiquitin-protein ligase ARIH2
ARIH2	O95376	371	419	359	493	Region	Note=Ariadne domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4X5
ARIH2	O95376	442	470	359	493	Region	Note=Ariadne domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4X5
ARIH2	O95376	371	419	359	493	Region	Note=Ariadne domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4X5
ARIH2	O95376	442	470	359	493	Region	Note=Ariadne domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4X5
ARMC4	Q5T2S8	662	699	1	1044	Chain	ID=PRO_0000243931;Note=Armadillo repeat-containing protein 4
ARMC4	Q5T2S8	511	581	1	1044	Chain	ID=PRO_0000243931;Note=Armadillo repeat-containing protein 4
ARMC4	Q5T2S8	381	412	1	1044	Chain	ID=PRO_0000243931;Note=Armadillo repeat-containing protein 4
ARMC4	Q5T2S8	511	581	484	523	Repeat	Note=ARM 1
ARMC4	Q5T2S8	511	581	525	564	Repeat	Note=ARM 2
ARMC4	Q5T2S8	662	699	663	702	Repeat	Note=ARM 4
ARMC4	Q5T2S8	511	581	552	552	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
ARMC4	Q5T2S8	381	412	1	475	Alternative sequence	ID=VSP_056695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARID3A	Q99856	399	498	1	593	Chain	ID=PRO_0000200578;Note=AT-rich interactive domain-containing protein 3A
ARID3A	Q99856	399	498	444	541	Domain	Note=REKLES;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00819
ARID3A	Q99856	399	498	445	488	Region	Note=Important for nuclear localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARID3A	Q99856	399	498	490	513	Region	Note=Homodimerization
ARID3A	Q99856	399	498	424	445	Compositional bias	Note=Ala-rich
ARID3A	Q99856	399	498	399	399	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ARID3A	Q99856	399	498	452	452	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25218447;Dbxref=PMID:25218447
ARID3A	Q99856	399	498	462	462	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733
ARID3A	Q99856	399	498	461	461	Mutagenesis	Note=Abolishes nuclear targeting. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17400556;Dbxref=PMID:17400556
ARID3A	Q99856	399	498	423	423	Sequence conflict	Note=V->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALK	Q9UM73	1313	1357	19	1620	Chain	ID=PRO_0000016740;Note=ALK tyrosine kinase receptor
ALK	Q9UM73	262	317	19	1620	Chain	ID=PRO_0000016740;Note=ALK tyrosine kinase receptor
ALK	Q9UM73	262	317	19	1038	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALK	Q9UM73	1313	1357	1060	1620	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALK	Q9UM73	262	317	264	427	Domain	Note=MAM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00128
ALK	Q9UM73	1313	1357	1116	1392	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ALK	Q9UM73	262	317	285	285	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALK	Q9UM73	262	317	296	296	Natural variant	ID=VAR_041479;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56077855,PMID:17344846
ALK	Q9UM73	1313	1357	1328	1328	Natural variant	ID=VAR_041488;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56160491,PMID:17344846
ALK	Q9UM73	1313	1357	1308	1323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z55
ALK	Q9UM73	1313	1357	1335	1343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z55
ALK	Q9UM73	1313	1357	1356	1365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z55
ALS2	Q96Q42	1468	1526	1	1657	Chain	ID=PRO_0000080903;Note=Alsin
ALS2	Q96Q42	1279	1334	1	1657	Chain	ID=PRO_0000080903;Note=Alsin
ALS2	Q96Q42	1468	1526	1513	1657	Domain	Note=VPS9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00550
ALS2	Q96Q42	1468	1526	397	1657	Alternative sequence	ID=VSP_050522;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11586298,ECO:0000303|PubMed:14702039;Dbxref=PMID:11586298,PMID:14702039
ALS2	Q96Q42	1279	1334	397	1657	Alternative sequence	ID=VSP_050522;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11586298,ECO:0000303|PubMed:14702039;Dbxref=PMID:11586298,PMID:14702039
ALS2	Q96Q42	1468	1526	808	1657	Alternative sequence	ID=VSP_050524;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALS2	Q96Q42	1279	1334	808	1657	Alternative sequence	ID=VSP_050524;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AMBRA1	Q9C0C7	1039	1069	1	1298	Chain	ID=PRO_0000315703;Note=Activating molecule in BECN1-regulated autophagy protein 1
AMBRA1	Q9C0C7	840	877	1	1298	Chain	ID=PRO_0000315703;Note=Activating molecule in BECN1-regulated autophagy protein 1
AMBRA1	Q9C0C7	720	779	1	1298	Chain	ID=PRO_0000315703;Note=Activating molecule in BECN1-regulated autophagy protein 1
AMBRA1	Q9C0C7	691	719	1	1298	Chain	ID=PRO_0000315703;Note=Activating molecule in BECN1-regulated autophagy protein 1
AMBRA1	Q9C0C7	720	779	747	747	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:A2AH22
AMBRA1	Q9C0C7	691	719	691	719	Alternative sequence	ID=VSP_030655;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17589504,ECO:0000303|PubMed:17974005;Dbxref=PMID:17589504,PMID:17974005
AMBRA1	Q9C0C7	691	719	691	691	Alternative sequence	ID=VSP_030656;Note=In isoform 5. R->RRSLALSPRLEYSGAILAHCKLRLPGSCHSPASASQVAGTTGAHHHARLIFAFLVEMEFHHVSQAGLELLTSGDLPTSASQSAGITGVSHRAWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AMBRA1	Q9C0C7	720	779	721	780	Alternative sequence	ID=VSP_030657;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214970;Dbxref=PMID:11214970
AMBRA1	Q9C0C7	840	877	864	880	Alternative sequence	ID=VSP_045989;Note=In isoform 6. WWDFTKFDLPEISNASV->GGGTSLSLTSLKSVMLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AMBRA1	Q9C0C7	1039	1069	881	1298	Alternative sequence	ID=VSP_045990;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AMBRA1	Q9C0C7	840	877	869	869	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PRMT7	Q9NVM4	44	94	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	397	425	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	425	441	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	441	471	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	347	375	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	375	391	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	391	421	1	692	Chain	ID=PRO_0000212335;Note=Protein arginine N-methyltransferase 7
PRMT7	Q9NVM4	44	94	14	345	Domain	Note=SAM-dependent MTase PRMT-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	397	425	358	684	Domain	Note=SAM-dependent MTase PRMT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	425	441	358	684	Domain	Note=SAM-dependent MTase PRMT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	441	471	358	684	Domain	Note=SAM-dependent MTase PRMT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	347	375	358	684	Domain	Note=SAM-dependent MTase PRMT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	375	391	358	684	Domain	Note=SAM-dependent MTase PRMT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	391	421	358	684	Domain	Note=SAM-dependent MTase PRMT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015
PRMT7	Q9NVM4	44	94	45	94	Alternative sequence	ID=VSP_037253;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PRMT7	Q9NVM4	397	425	399	472	Alternative sequence	ID=VSP_005214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11572484;Dbxref=PMID:11572484
PRMT7	Q9NVM4	425	441	399	472	Alternative sequence	ID=VSP_005214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11572484;Dbxref=PMID:11572484
PRMT7	Q9NVM4	441	471	399	472	Alternative sequence	ID=VSP_005214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11572484;Dbxref=PMID:11572484
PRMT7	Q9NVM4	391	421	399	472	Alternative sequence	ID=VSP_005214;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11572484;Dbxref=PMID:11572484
PRMT7	Q9NVM4	375	391	387	387	Natural variant	ID=VAR_076330;Note=In SBIDDS. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26437029;Dbxref=dbSNP:rs762515973,PMID:26437029
NPR1	P16066	560	586	33	1061	Chain	ID=PRO_0000012360;Note=Atrial natriuretic peptide receptor 1
NPR1	P16066	896	919	33	1061	Chain	ID=PRO_0000012360;Note=Atrial natriuretic peptide receptor 1
NPR1	P16066	560	586	495	1061	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPR1	P16066	896	919	495	1061	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPR1	P16066	560	586	528	805	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
NPR1	P16066	896	919	876	1006	Domain	Note=Guanylate cyclase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00099
ANKRD46	Q86W74	104	156	1	232	Chain	ID=PRO_0000244577;Note=Ankyrin repeat domain-containing protein 46
ANKRD46	Q86W74	104	156	107	138	Repeat	Note=ANK 4
ANKRD52	Q8NB46	87	154	1	1076	Chain	ID=PRO_0000244587;Note=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
ANKRD52	Q8NB46	87	154	73	102	Repeat	Note=ANK 3
ANKRD52	Q8NB46	87	154	106	135	Repeat	Note=ANK 4
ANKRD52	Q8NB46	87	154	139	168	Repeat	Note=ANK 5
ANKRD23	Q86SG2	100	142	1	305	Chain	ID=PRO_0000240666;Note=Ankyrin repeat domain-containing protein 23
ANKRD23	Q86SG2	100	142	1	305	Chain	ID=PRO_0000240666;Note=Ankyrin repeat domain-containing protein 23
ANKRD23	Q86SG2	100	142	101	142	Alternative sequence	ID=VSP_019424;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD23	Q86SG2	100	142	101	142	Alternative sequence	ID=VSP_019424;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAOA	P21397	56	102	1	527	Chain	ID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
MAOA	P21397	102	137	1	527	Chain	ID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
MAOA	P21397	351	368	1	527	Chain	ID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
MAOA	P21397	56	102	1	497	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
MAOA	P21397	102	137	1	497	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
MAOA	P21397	351	368	1	497	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
MAOA	P21397	56	102	1	133	Alternative sequence	ID=VSP_045173;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAOA	P21397	102	137	1	133	Alternative sequence	ID=VSP_045173;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAOA	P21397	56	102	54	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5X
MAOA	P21397	56	102	58	60	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	56	102	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	56	102	75	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	56	102	88	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	56	102	94	101	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	102	137	104	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	102	137	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	102	137	118	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	351	368	348	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	351	368	355	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
MAOA	P21397	351	368	366	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
AP1G1	O43747	756	789	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	666	702	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	469	499	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	363	409	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	273	306	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	214	246	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	756	789	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	666	702	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	469	499	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	363	409	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	273	306	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	214	246	1	822	Chain	ID=PRO_0000193758;Note=AP-1 complex subunit gamma-1
AP1G1	O43747	756	789	702	817	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
AP1G1	O43747	666	702	702	817	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
AP1G1	O43747	756	789	702	817	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
AP1G1	O43747	666	702	702	817	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
AP1G1	O43747	666	702	685	685	Natural variant	ID=VAR_013572;Note=P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9733768;Dbxref=dbSNP:rs904763,PMID:9733768
AP1G1	O43747	666	702	685	685	Natural variant	ID=VAR_013572;Note=P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9733768;Dbxref=dbSNP:rs904763,PMID:9733768
AP1G1	O43747	756	789	758	762	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IU1
AP1G1	O43747	756	789	758	762	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IU1
AP1G1	O43747	756	789	772	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IU1
AP1G1	O43747	756	789	772	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IU1
AP1G1	O43747	756	789	778	785	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IU1
AP1G1	O43747	756	789	778	785	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IU1
TFAP2B	Q92481	27	180	1	460	Chain	ID=PRO_0000184801;Note=Transcription factor AP-2-beta
TFAP2B	Q92481	27	180	41	131	Compositional bias	Note=Gln/Pro-rich (transactivation domain)
TFAP2B	Q92481	27	180	27	27	Alternative sequence	ID=VSP_006408;Note=In isoform 2. E->EMLVHTYSSM;Ontology_term=ECO:0000305;evidence=ECO:0000305
TFAP2B	Q92481	27	180	73	73	Natural variant	ID=VAR_016977;Note=In CHAR. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11505339;Dbxref=dbSNP:rs80338910,PMID:11505339
ARPC1A	Q92747	21	56	1	370	Chain	ID=PRO_0000050852;Note=Actin-related protein 2/3 complex subunit 1A
ARPC1A	Q92747	131	166	1	370	Chain	ID=PRO_0000050852;Note=Actin-related protein 2/3 complex subunit 1A
ARPC1A	Q92747	167	237	1	370	Chain	ID=PRO_0000050852;Note=Actin-related protein 2/3 complex subunit 1A
ARPC1A	Q92747	21	56	6	45	Repeat	Note=WD 1
ARPC1A	Q92747	21	56	50	89	Repeat	Note=WD 2
ARPC1A	Q92747	131	166	140	179	Repeat	Note=WD 3
ARPC1A	Q92747	167	237	140	179	Repeat	Note=WD 3
ARPC1A	Q92747	167	237	202	241	Repeat	Note=WD 4
ARPC1A	Q92747	21	56	1	57	Alternative sequence	ID=VSP_056389;Note=In isoform 2. MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITG->MHERFIHCFC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARPC1A	Q92747	167	237	180	180	Sequence conflict	Note=P->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
AREG	P15514	171	221	101	187	Chain	ID=PRO_0000007474;Note=Amphiregulin
AREG	P15514	171	221	188	252	Propeptide	ID=PRO_0000007475
AREG	P15514	171	221	199	221	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AREG	P15514	171	221	142	182	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
AREG	P15514	171	221	172	181	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|Ref.14
AREG	P15514	171	221	167	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RNL
AREG	P15514	171	221	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RNL
AMMECR1L	Q6DCA0	136	172	1	310	Chain	ID=PRO_0000278479;Note=AMMECR1-like protein
AMMECR1L	Q6DCA0	136	172	1	310	Chain	ID=PRO_0000278479;Note=AMMECR1-like protein
AMMECR1L	Q6DCA0	136	172	97	291	Domain	Note=AMMECR1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00467
AMMECR1L	Q6DCA0	136	172	97	291	Domain	Note=AMMECR1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00467
ANP32B	Q92688	68	109	1	251	Chain	ID=PRO_0000137595;Note=Acidic leucine-rich nuclear phosphoprotein 32 family member B
ANP32B	Q92688	68	109	65	84	Repeat	Note=LRR 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20538007;Dbxref=PMID:20538007
ANP32B	Q92688	68	109	89	110	Repeat	Note=LRR 4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20538007;Dbxref=PMID:20538007
ANP32B	Q92688	68	109	86	86	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANP32B	Q92688	68	109	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ELL
ANP32B	Q92688	68	109	82	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ELL
ANP32B	Q92688	68	109	92	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ELL
ANP32B	Q92688	68	109	96	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ELL
ANP32B	Q92688	68	109	104	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ELL
ANKRD13A	Q8IZ07	133	181	1	590	Chain	ID=PRO_0000066909;Note=Ankyrin repeat domain-containing protein 13A
ANKRD13A	Q8IZ07	411	449	1	590	Chain	ID=PRO_0000066909;Note=Ankyrin repeat domain-containing protein 13A
ANPEP	P15144	843	889	2	967	Chain	ID=PRO_0000095081;Note=Aminopeptidase N
ANPEP	P15144	479	501	2	967	Chain	ID=PRO_0000095081;Note=Aminopeptidase N
ANPEP	P15144	843	889	33	967	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1350662;Dbxref=PMID:1350662
ANPEP	P15144	479	501	33	967	Topological domain	Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1350662;Dbxref=PMID:1350662
ANPEP	P15144	843	889	69	967	Region	Note=Metalloprotease
ANPEP	P15144	479	501	69	967	Region	Note=Metalloprotease
ANPEP	P15144	843	889	887	887	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANPEP	P15144	479	501	474	491	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	479	501	493	507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	843	889	838	848	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	843	889	851	853	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	843	889	856	858	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	843	889	859	868	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	843	889	872	882	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
ANPEP	P15144	843	889	884	890	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4FYT
AR	P10275	589	628	1	920	Chain	ID=PRO_0000053704;Note=Androgen receptor
AR	P10275	589	628	560	632	DNA binding	Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
AR	P10275	589	628	596	620	Zinc finger	Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407
AR	P10275	589	628	552	919	Region	Note=Interaction with LPXN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18451096;Dbxref=PMID:18451096
AR	P10275	589	628	572	662	Region	Note=Interaction with HIPK3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15207
AR	P10275	589	628	592	919	Region	Note=Interaction with CCAR1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23887938;Dbxref=PMID:23887938
AR	P10275	589	628	625	919	Region	Note=Interaction with KAT7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10930412;Dbxref=PMID:10930412
AR	P10275	589	628	597	597	Natural variant	ID=VAR_009743;Note=In AIS%3B abolishes dimerization. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10590024,ECO:0000269|PubMed:7649358;Dbxref=dbSNP:rs137852569,PMID:10590024,PMID:7649358
AR	P10275	589	628	598	598	Natural variant	ID=VAR_009744;Note=In PAIS%3B associated with P-618 in a PAIS patient%3B normal androgen binding%3B does not activate transcription%3B impairs DNA binding. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1316540;Dbxref=dbSNP:rs142280455,PMID:1316540
AR	P10275	589	628	598	598	Natural variant	ID=VAR_009745;Note=In a patient with severe hypospadias. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092153;Dbxref=PMID:10092153
AR	P10275	589	628	602	602	Natural variant	ID=VAR_009746;Note=In AIS. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7981689;Dbxref=PMID:7981689
AR	P10275	589	628	605	605	Natural variant	ID=VAR_009747;Note=In PAIS. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7981687;Dbxref=PMID:7981687
AR	P10275	589	628	608	608	Natural variant	ID=VAR_004684;Note=In PAIS and breast cancer. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10221692,ECO:0000269|PubMed:1303262,ECO:0000269|PubMed:9039340,ECO:0000269|PubMed:9543136;Dbxref=dbSNP:rs137852573,PMID:10221692,PMID:1303262,PMID:9039340,PMID:9543136
AR	P10275	589	628	609	609	Natural variant	ID=VAR_004685;Note=In PAIS and breast cancer%3B defective nuclear localization. R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1424203,ECO:0000269|PubMed:8281139,ECO:0000269|PubMed:9196614;Dbxref=dbSNP:rs137852576,PMID:1424203,PMID:8281139,PMID:9196614
AR	P10275	589	628	611	611	Natural variant	ID=VAR_009748;Note=In PAIS. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9039340;Dbxref=PMID:9039340
AR	P10275	589	628	612	612	Natural variant	ID=VAR_009749;Note=In AIS. C->Y
AR	P10275	589	628	616	616	Natural variant	ID=VAR_009751;Note=In AIS and PAIS. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7970939,ECO:0000269|PubMed:8162033,ECO:0000269|PubMed:8413310,ECO:0000269|PubMed:9698822;Dbxref=dbSNP:rs754201976,PMID:7970939,PMID:8162033,PMID:8413310,PMID:9698822
AR	P10275	589	628	616	616	Natural variant	ID=VAR_009752;Note=In AIS. R->P
AR	P10275	589	628	616	616	Natural variant	ID=VAR_009750;Note=In AIS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8162033;Dbxref=PMID:8162033
AR	P10275	589	628	617	617	Natural variant	ID=VAR_009753;Note=In AIS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8647313;Dbxref=PMID:8647313
AR	P10275	589	628	617	617	Natural variant	ID=VAR_009754;Note=In PAIS. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8126121;Dbxref=PMID:8126121
AR	P10275	589	628	618	618	Natural variant	ID=VAR_009755;Note=In AIS and PAIS%3B associated with G-598 in a PAIS patient%3B loss of DNA-binding activity. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1316540,ECO:0000269|PubMed:1999491;Dbxref=PMID:1316540,PMID:1999491
AR	P10275	589	628	620	620	Natural variant	ID=VAR_009756;Note=In prostate cancer%3B loss of DNA binding%3B somatic mutation. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10598582,ECO:0000269|PubMed:10706109;Dbxref=PMID:10598582,PMID:10706109
ANKRA2	Q9H9E1	268	295	1	313	Chain	ID=PRO_0000066895;Note=Ankyrin repeat family A protein 2
ANKRA2	Q9H9E1	204	246	1	313	Chain	ID=PRO_0000066895;Note=Ankyrin repeat family A protein 2
ANKRA2	Q9H9E1	96	149	1	313	Chain	ID=PRO_0000066895;Note=Ankyrin repeat family A protein 2
ANKRA2	Q9H9E1	96	149	148	180	Repeat	Note=ANK 1
ANKRA2	Q9H9E1	204	246	181	213	Repeat	Note=ANK 2
ANKRA2	Q9H9E1	204	246	214	246	Repeat	Note=ANK 3
ANKRA2	Q9H9E1	268	295	247	279	Repeat	Note=ANK 4
ANKRA2	Q9H9E1	268	295	280	313	Repeat	Note=ANK 5
ANKRA2	Q9H9E1	96	149	144	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QQI
ANKRA2	Q9H9E1	96	149	148	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V2X
ANKRA2	Q9H9E1	204	246	218	225	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V31
ANKRA2	Q9H9E1	204	246	228	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V31
ANKRA2	Q9H9E1	268	295	261	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V31
ANKRA2	Q9H9E1	268	295	284	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V31
ANKRA2	Q9H9E1	268	295	294	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V31
ANKRD44	Q8N8A2	804	831	1	993	Chain	ID=PRO_0000244572;Note=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
ANKRD44	Q8N8A2	478	504	1	993	Chain	ID=PRO_0000244572;Note=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
ANKRD44	Q8N8A2	408	430	1	993	Chain	ID=PRO_0000244572;Note=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
ANKRD44	Q8N8A2	408	430	404	433	Repeat	Note=ANK 13
ANKRD44	Q8N8A2	478	504	470	498	Repeat	Note=ANK 15
ANKRD44	Q8N8A2	804	831	803	832	Repeat	Note=ANK 24
ANKRD44	Q8N8A2	804	831	368	993	Alternative sequence	ID=VSP_035966;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD44	Q8N8A2	478	504	368	993	Alternative sequence	ID=VSP_035966;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD44	Q8N8A2	408	430	368	993	Alternative sequence	ID=VSP_035966;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD44	Q8N8A2	804	831	580	993	Alternative sequence	ID=VSP_019603;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NPR3	P17342	256	297	27	541	Chain	ID=PRO_0000012370;Note=Atrial natriuretic peptide receptor 3
NPR3	P17342	256	297	27	481	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
NPR3	P17342	256	297	293	293	Glycosylation	Note=N-linked (GlcNAc...) (high mannose) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11533490,ECO:0000269|PubMed:16870210,ECO:0000269|PubMed:7727388;Dbxref=PMID:11533490,PMID:16870210,PMID:7727388
NPR3	P17342	256	297	213	261	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11533490,ECO:0000269|PubMed:16870210,ECO:0000269|PubMed:7727388;Dbxref=PMID:11533490,PMID:16870210,PMID:7727388
NPR3	P17342	256	297	41	256	Alternative sequence	ID=VSP_045902;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
NPR3	P17342	256	297	256	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDP
NPR3	P17342	256	297	264	276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDP
NPR3	P17342	256	297	280	283	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDP
NPR3	P17342	256	297	285	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDP
NPR3	P17342	256	297	291	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDN
NPR3	P17342	256	297	297	299	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JDP
ANO9	A1A5B4	544	595	1	782	Chain	ID=PRO_0000289329;Note=Anoctamin-9
ANO9	A1A5B4	180	224	1	782	Chain	ID=PRO_0000289329;Note=Anoctamin-9
ANO9	A1A5B4	27	68	1	782	Chain	ID=PRO_0000289329;Note=Anoctamin-9
ANO9	A1A5B4	2	27	1	782	Chain	ID=PRO_0000289329;Note=Anoctamin-9
ANO9	A1A5B4	180	224	1	198	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	27	68	1	198	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	2	27	1	198	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	180	224	199	219	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	180	224	220	264	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	544	595	445	552	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	544	595	553	573	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	544	595	574	604	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO9	A1A5B4	180	224	1	299	Alternative sequence	ID=VSP_036489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANO9	A1A5B4	27	68	1	299	Alternative sequence	ID=VSP_036489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANO9	A1A5B4	2	27	1	299	Alternative sequence	ID=VSP_036489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANO9	A1A5B4	180	224	156	186	Alternative sequence	ID=VSP_036490;Note=In isoform 3. GEGRLKKTWARWRHMFREQPVDEIRNYFGEK->VRGGPAWRGPWGGTLGWGLSLSVTRARGRDA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANO9	A1A5B4	544	595	187	782	Alternative sequence	ID=VSP_036491;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANO9	A1A5B4	180	224	187	782	Alternative sequence	ID=VSP_036491;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKH	Q9HCJ1	229	274	1	492	Chain	ID=PRO_0000137467;Note=Progressive ankylosis protein homolog
ANKH	Q9HCJ1	172	229	1	492	Chain	ID=PRO_0000137467;Note=Progressive ankylosis protein homolog
ANKH	Q9HCJ1	144	172	1	492	Chain	ID=PRO_0000137467;Note=Progressive ankylosis protein homolog
ANKH	Q9HCJ1	144	172	132	152	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	144	172	153	158	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	172	229	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	144	172	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	172	229	180	189	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	172	229	190	210	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	229	274	211	326	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	172	229	211	326	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKH	Q9HCJ1	172	229	1	198	Alternative sequence	ID=VSP_055824;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKH	Q9HCJ1	144	172	1	198	Alternative sequence	ID=VSP_055824;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD54	Q6NXT1	240	276	2	300	Chain	ID=PRO_0000274493;Note=Ankyrin repeat domain-containing protein 54
ANKRD54	Q6NXT1	158	182	2	300	Chain	ID=PRO_0000274493;Note=Ankyrin repeat domain-containing protein 54
ANKRD54	Q6NXT1	125	158	2	300	Chain	ID=PRO_0000274493;Note=Ankyrin repeat domain-containing protein 54
ANKRD54	Q6NXT1	125	158	109	138	Repeat	Note=ANK 1
ANKRD54	Q6NXT1	158	182	142	171	Repeat	Note=ANK 2
ANKRD54	Q6NXT1	125	158	142	171	Repeat	Note=ANK 2
ANKRD54	Q6NXT1	158	182	175	204	Repeat	Note=ANK 3
ANKRD54	Q6NXT1	240	276	208	244	Repeat	Note=ANK 4
ANKRD54	Q6NXT1	240	276	141	241	Region	Note=LYN-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
ANKRD54	Q6NXT1	158	182	141	241	Region	Note=LYN-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
ANKRD54	Q6NXT1	125	158	141	241	Region	Note=LYN-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
ANKRD54	Q6NXT1	125	158	1	139	Alternative sequence	ID=VSP_022770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD54	Q6NXT1	158	182	140	198	Alternative sequence	ID=VSP_022771;Note=In isoform 2. DDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRG->MVLILTSEMGWGTRHCTWRPAPTTFLSSPHCYEEVCGFFPSLSSFSPSPPECSPQLVPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD54	Q6NXT1	125	158	140	198	Alternative sequence	ID=VSP_022771;Note=In isoform 2. DDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRG->MVLILTSEMGWGTRHCTWRPAPTTFLSSPHCYEEVCGFFPSLSSFSPSPPECSPQLVPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD55	Q3KP44	161	204	1	614	Chain	ID=PRO_0000274410;Note=Ankyrin repeat domain-containing protein 55
ANKRD55	Q3KP44	161	204	161	190	Repeat	Note=ANK 5
ANKRD55	Q3KP44	161	204	194	223	Repeat	Note=ANK 6
ANKRD55	Q3KP44	161	204	1	288	Alternative sequence	ID=VSP_022740;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ANXA13	P27216	157	180	2	316	Chain	ID=PRO_0000067514;Note=Annexin A13
ANXA13	P27216	62	119	2	316	Chain	ID=PRO_0000067514;Note=Annexin A13
ANXA13	P27216	62	119	23	83	Repeat	Note=Annexin 1
ANXA13	P27216	62	119	95	155	Repeat	Note=Annexin 2
ANXA13	P27216	157	180	179	239	Repeat	Note=Annexin 3
ANXA13	P27216	62	119	86	86	Natural variant	ID=VAR_055501;Note=R->H;Dbxref=dbSNP:rs2294013
ANXA13	P27216	62	119	108	108	Natural variant	ID=VAR_055502;Note=V->I;Dbxref=dbSNP:rs6995099
ANXA13	P27216	62	119	112	112	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
APMAP	Q9HDC9	140	179	2	416	Chain	ID=PRO_0000205945;Note=Adipocyte plasma membrane-associated protein
APMAP	Q9HDC9	109	140	2	416	Chain	ID=PRO_0000205945;Note=Adipocyte plasma membrane-associated protein
APMAP	Q9HDC9	32	70	2	416	Chain	ID=PRO_0000205945;Note=Adipocyte plasma membrane-associated protein
APMAP	Q9HDC9	32	70	2	40	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
APMAP	Q9HDC9	32	70	41	61	Transmembrane	Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255
APMAP	Q9HDC9	140	179	62	416	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
APMAP	Q9HDC9	109	140	62	416	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
APMAP	Q9HDC9	32	70	62	416	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
APMAP	Q9HDC9	140	179	160	160	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:16335952,PMID:19159218
APMAP	Q9HDC9	32	70	65	65	Natural variant	ID=VAR_014128;Note=I->V;Dbxref=dbSNP:rs12242
ARAP2	Q8WZ64	1536	1581	1	1704	Chain	ID=PRO_0000074212;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 2
ARAP2	Q8WZ64	1385	1428	1	1704	Chain	ID=PRO_0000074212;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 2
ARAP2	Q8WZ64	1298	1321	1	1704	Chain	ID=PRO_0000074212;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 2
ARAP2	Q8WZ64	872	917	1	1704	Chain	ID=PRO_0000074212;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 2
ARAP2	Q8WZ64	872	917	878	1003	Domain	Note=PH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARAP2	Q8WZ64	1385	1428	1326	1420	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
ARAP2	Q8WZ64	1536	1581	1434	1537	Domain	Note=PH 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARAP3	Q8WWN8	1370	1383	1	1544	Chain	ID=PRO_0000074215;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 3
ARAP3	Q8WWN8	1175	1218	1	1544	Chain	ID=PRO_0000074215;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 3
ARAP3	Q8WWN8	1112	1137	1	1544	Chain	ID=PRO_0000074215;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 3
ARAP3	Q8WWN8	933	1004	1	1544	Chain	ID=PRO_0000074215;Note=Arf-GAP with Rho-GAP domain%2C ANK repeat and PH domain-containing protein 3
ARAP3	Q8WWN8	933	1004	907	1088	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172
ARAP3	Q8WWN8	1175	1218	1117	1210	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
ARAP3	Q8WWN8	1112	1137	1117	1210	Domain	Note=Ras-associating;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00166
ARAP3	Q8WWN8	1370	1383	1371	1383	Alternative sequence	ID=VSP_056215;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARAP3	Q8WWN8	933	1004	921	933	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	934	936	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	938	942	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	947	960	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	961	963	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	968	970	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	973	986	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	987	989	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	994	996	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARAP3	Q8WWN8	933	1004	997	1004	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JCP
ARPC1B	O15143	167	235	2	372	Chain	ID=PRO_0000050855;Note=Actin-related protein 2/3 complex subunit 1B
ARPC1B	O15143	167	235	2	372	Chain	ID=PRO_0000050855;Note=Actin-related protein 2/3 complex subunit 1B
ARPC1B	O15143	167	235	140	179	Repeat	Note=WD 4
ARPC1B	O15143	167	235	140	179	Repeat	Note=WD 4
EIF4ENIF1	Q9NRA8	504	528	1	985	Chain	ID=PRO_0000064381;Note=Eukaryotic translation initiation factor 4E transporter
EIF4ENIF1	Q9NRA8	504	528	1	985	Chain	ID=PRO_0000064381;Note=Eukaryotic translation initiation factor 4E transporter
EIF4ENIF1	Q9NRA8	504	528	513	513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EIF4ENIF1	Q9NRA8	504	528	513	513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EIF4ENIF1	Q9NRA8	504	528	493	504	Alternative sequence	ID=VSP_003784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4ENIF1	Q9NRA8	504	528	493	504	Alternative sequence	ID=VSP_003784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NT5C3B	Q969T7	189	256	1	300	Chain	ID=PRO_0000328948;Note=7-methylguanosine phosphate-specific 5'-nucleotidase
NT5C3B	Q969T7	105	134	1	300	Chain	ID=PRO_0000328948;Note=7-methylguanosine phosphate-specific 5'-nucleotidase
NT5C3B	Q969T7	4	37	1	300	Chain	ID=PRO_0000328948;Note=7-methylguanosine phosphate-specific 5'-nucleotidase
NT5C3B	Q969T7	189	256	230	230	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9W197
NT5C3B	Q969T7	189	256	205	205	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9H0P0
NT5C3B	Q969T7	189	256	256	256	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
NT5C3B	Q969T7	4	37	1	8	Alternative sequence	ID=VSP_046297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
NT5C3B	Q969T7	189	256	209	209	Natural variant	ID=VAR_042582;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1046403,PMID:15489334
NT5C3B	Q969T7	189	256	213	213	Natural variant	ID=VAR_042583;Note=S->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs1046404,PMID:15489334
A1BG	P04217	11	23	1	21	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201
A1BG	P04217	303	397	22	495	Chain	ID=PRO_0000014502;Note=Alpha-1B-glycoprotein
A1BG	P04217	11	23	22	495	Chain	ID=PRO_0000014502;Note=Alpha-1B-glycoprotein
A1BG	P04217	11	23	22	113	Domain	Note=Ig-like V-type 1
A1BG	P04217	303	397	300	397	Domain	Note=Ig-like V-type 4
A1BG	P04217	303	397	363	363	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:16335952,PMID:3458201
A1BG	P04217	303	397	371	371	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:16335952,PMID:3458201
A1BG	P04217	303	397	325	374	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201
A1BG	P04217	11	23	1	122	Alternative sequence	ID=VSP_040323;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
A1BG	P04217	303	397	395	395	Natural variant	ID=VAR_018370;Note=H->R;Dbxref=dbSNP:rs2241788
A1BG	P04217	303	397	304	304	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACAP3	Q96P50	147	179	1	834	Chain	ID=PRO_0000356159;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 3
ACAP3	Q96P50	132	147	1	834	Chain	ID=PRO_0000356159;Note=Arf-GAP with coiled-coil%2C ANK repeat and PH domain-containing protein 3
ACAP3	Q96P50	147	179	1	270	Alternative sequence	ID=VSP_035992;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACAP3	Q96P50	132	147	1	270	Alternative sequence	ID=VSP_035992;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SLC33A1	O00400	422	494	1	549	Chain	ID=PRO_0000076165;Note=Acetyl-coenzyme A transporter 1
SLC33A1	O00400	422	494	1	549	Chain	ID=PRO_0000076165;Note=Acetyl-coenzyme A transporter 1
SLC33A1	O00400	422	494	405	425	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC33A1	O00400	422	494	405	425	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC33A1	O00400	422	494	426	508	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC33A1	O00400	422	494	426	508	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ACAD9	Q9H845	383	426	426	426	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACAD9	Q9H845	521	564	521	521	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZN5
ACAD9	Q9H845	521	564	521	521	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8JZN5
ACAD9	Q9H845	383	426	384	384	Natural variant	ID=VAR_076178;Note=In ACAD9 deficiency. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26741492;Dbxref=PMID:26741492
ACAD9	Q9H845	383	426	413	413	Natural variant	ID=VAR_071900;Note=In ACAD9 deficiency%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20816094;Dbxref=dbSNP:rs149753643,PMID:20816094
ACAD9	Q9H845	383	426	414	414	Natural variant	ID=VAR_071901;Note=In ACAD9 deficiency. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23836383;Dbxref=dbSNP:rs777282696,PMID:23836383
ACAD9	Q9H845	383	426	417	417	Natural variant	ID=VAR_071902;Note=In ACAD9 deficiency. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21057504;Dbxref=dbSNP:rs368949613,PMID:21057504
ACAD9	Q9H845	521	564	532	532	Natural variant	ID=VAR_071905;Note=In ACAD9 deficiency. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20929961,ECO:0000269|PubMed:21057504,ECO:0000269|PubMed:22499348;Dbxref=dbSNP:rs377022708,PMID:20929961,PMID:21057504,PMID:22499348
ACAD9	Q9H845	383	426	426	426	Mutagenesis	Note=Catalytically inactive. Does not affect mitochondrial complex I assembly. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24158852;Dbxref=PMID:24158852
ACAD9	Q9H845	383	426	397	397	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACOT11	Q8WXI4	255	294	1	607	Chain	ID=PRO_0000053813;Note=Acyl-coenzyme A thioesterase 11
ACOT11	Q8WXI4	384	412	1	607	Chain	ID=PRO_0000053813;Note=Acyl-coenzyme A thioesterase 11
ACOT11	Q8WXI4	457	500	1	607	Chain	ID=PRO_0000053813;Note=Acyl-coenzyme A thioesterase 11
ACOT11	Q8WXI4	255	294	216	329	Domain	Note=HotDog ACOT-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01106
ACOT11	Q8WXI4	384	412	375	585	Domain	Note=START;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00197
ACOT11	Q8WXI4	457	500	375	585	Domain	Note=START;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00197
ACOT11	Q8WXI4	255	294	271	273	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACOT11	Q8WXI4	255	294	255	255	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ACOT11	Q8WXI4	384	412	384	399	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FO5
ACOT11	Q8WXI4	384	412	405	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FO5
ACOT11	Q8WXI4	457	500	458	466	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FO5
ACOT11	Q8WXI4	457	500	469	476	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FO5
ACOT11	Q8WXI4	457	500	486	495	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FO5
ACSM2A	Q08AH3	199	246	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	393	427	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	199	246	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	393	427	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	199	246	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	393	427	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	199	246	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	393	427	47	577	Chain	ID=PRO_0000306093;Note=Acyl-coenzyme A synthetase ACSM2A%2C mitochondrial
ACSM2A	Q08AH3	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19345228,ECO:0000269|Ref.6;Dbxref=PMID:19345228
ACSM2A	Q08AH3	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19345228,ECO:0000269|Ref.6;Dbxref=PMID:19345228
ACSM2A	Q08AH3	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19345228,ECO:0000269|Ref.6;Dbxref=PMID:19345228
ACSM2A	Q08AH3	199	246	221	229	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19345228,ECO:0000269|Ref.6;Dbxref=PMID:19345228
ACSM2A	Q08AH3	199	246	194	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	194	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	194	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	194	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	214	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	224	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	224	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	224	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	224	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	230	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	230	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	230	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	230	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	235	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	235	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	235	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	235	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	246	249	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	246	249	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	246	249	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	199	246	246	249	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	392	395	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	392	395	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	392	395	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	392	395	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	408	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	408	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	408	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	408	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	415	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	415	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	415	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACSM2A	Q08AH3	393	427	415	417	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3C5E
ACTA1	P68133	151	205	2	377	Chain	ID=PRO_0000442803;Note=Actin%2C alpha skeletal muscle%2C intermediate form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62737
ACTA1	P68133	151	205	3	377	Chain	ID=PRO_0000442804;Note=Actin%2C alpha skeletal muscle;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68135
ACTA1	P68133	151	205	156	156	Natural variant	ID=VAR_062447;Note=In NEM3. D->N
ACTA1	P68133	151	205	165	165	Natural variant	ID=VAR_011684;Note=In MPCETM. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10508519,ECO:0000269|PubMed:15198992;Dbxref=dbSNP:rs121909522,PMID:10508519,PMID:15198992
ACTA1	P68133	151	205	165	165	Natural variant	ID=VAR_062448;Note=In NEM3%3B results in sequestration of sarcomeric and Z line proteins into intranuclear aggregates%3B there is some evidence of muscle regeneration suggesting a compensatory effect. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15198992,ECO:0000269|PubMed:16427282,ECO:0000269|PubMed:17705262;Dbxref=dbSNP:rs121909522,PMID:15198992,PMID:16427282,PMID:17705262
ACTA1	P68133	151	205	172	172	Natural variant	ID=VAR_062449;Note=In NEM3. A->G
ACTA1	P68133	151	205	181	181	Natural variant	ID=VAR_062450;Note=In NEM3. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15236405;Dbxref=PMID:15236405
ACTA1	P68133	151	205	181	181	Natural variant	ID=VAR_062451;Note=In NEM3. D->H
ACTA1	P68133	151	205	181	181	Natural variant	ID=VAR_062452;Note=In NEM3. D->N
ACTA1	P68133	151	205	184	184	Natural variant	ID=VAR_015580;Note=In NEM3%3B mild. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10508519,ECO:0000269|PubMed:15236405;Dbxref=PMID:10508519,PMID:15236405
ACTA1	P68133	151	205	185	185	Natural variant	ID=VAR_015582;Note=In NEM3%3B severe. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10508519;Dbxref=PMID:10508519
ACTA1	P68133	151	205	185	185	Natural variant	ID=VAR_062453;Note=In NEM3%3B requires 2 nucleotide substitutions. R->D
ACTA1	P68133	151	205	185	185	Natural variant	ID=VAR_015581;Note=In NEM3%3B autosomal dominant%3B severe. R->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11333380,ECO:0000269|PubMed:15198992,ECO:0000269|PubMed:15236405;Dbxref=PMID:11333380,PMID:15198992,PMID:15236405
ACTA1	P68133	151	205	185	185	Natural variant	ID=VAR_062454;Note=In NEM3. R->S;Dbxref=dbSNP:rs1064794287
ACTA1	P68133	151	205	197	197	Natural variant	ID=VAR_076426;Note=In SHPM%3B no effect on cytoskeleton structure. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25938801;Dbxref=dbSNP:rs869312739,PMID:25938801
ACTA1	P68133	151	205	198	198	Natural variant	ID=VAR_062455;Note=In NEM3. R->L
ACTA1	P68133	151	205	199	199	Natural variant	ID=VAR_062456;Note=In NEM3. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15236405;Dbxref=PMID:15236405
ADCY2	Q08462	136	190	1	1091	Chain	ID=PRO_0000195684;Note=Adenylate cyclase type 2
ADCY2	Q08462	190	240	1	1091	Chain	ID=PRO_0000195684;Note=Adenylate cyclase type 2
ADCY2	Q08462	652	698	1	1091	Chain	ID=PRO_0000195684;Note=Adenylate cyclase type 2
ADCY2	Q08462	698	738	1	1091	Chain	ID=PRO_0000195684;Note=Adenylate cyclase type 2
ADCY2	Q08462	823	876	1	1091	Chain	ID=PRO_0000195684;Note=Adenylate cyclase type 2
ADCY2	Q08462	136	190	133	153	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	136	190	159	179	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	136	190	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	190	240	187	207	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	190	240	208	601	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	652	698	628	652	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	652	698	680	701	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	698	738	680	701	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	698	738	734	755	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	823	876	822	1091	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	698	738	713	713	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	698	738	716	716	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY2	Q08462	136	190	60	239	Alternative sequence	ID=VSP_055812;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADCY2	Q08462	190	240	60	239	Alternative sequence	ID=VSP_055812;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ADCY2	Q08462	136	190	147	147	Natural variant	ID=VAR_029012;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs13166360,PMID:15489334
ADCY2	Q08462	136	190	163	163	Natural variant	ID=VAR_048247;Note=V->I;Dbxref=dbSNP:rs34043481
ADCY2	Q08462	136	190	188	207	Sequence conflict	Note=VWQILANVIIFICGNLAGAY->GLADPGQCDHFHLWEPGXTN;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADCY2	Q08462	190	240	188	207	Sequence conflict	Note=VWQILANVIIFICGNLAGAY->GLADPGQCDHFHLWEPGXTN;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADCY2	Q08462	652	698	675	675	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
ADCY2	Q08462	652	698	675	675	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
AGPS	O00116	187	212	59	658	Chain	ID=PRO_0000020431;Note=Alkyldihydroxyacetonephosphate synthase%2C peroxisomal
AGPS	O00116	212	236	59	658	Chain	ID=PRO_0000020431;Note=Alkyldihydroxyacetonephosphate synthase%2C peroxisomal
AGPS	O00116	263	290	59	658	Chain	ID=PRO_0000020431;Note=Alkyldihydroxyacetonephosphate synthase%2C peroxisomal
AGPS	O00116	290	332	59	658	Chain	ID=PRO_0000020431;Note=Alkyldihydroxyacetonephosphate synthase%2C peroxisomal
AGPS	O00116	187	212	202	384	Domain	Note=FAD-binding PCMH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00718
AGPS	O00116	212	236	202	384	Domain	Note=FAD-binding PCMH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00718
AGPS	O00116	263	290	202	384	Domain	Note=FAD-binding PCMH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00718
AGPS	O00116	290	332	202	384	Domain	Note=FAD-binding PCMH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00718
AGPS	O00116	212	236	234	240	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
AGPS	O00116	290	332	303	309	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
AGPS	O00116	290	332	316	319	Nucleotide binding	Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250
AGPS	O00116	290	332	309	309	Natural variant	ID=VAR_025895;Note=In RCDP3. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152660;Dbxref=dbSNP:rs121434412,PMID:11152660
RNPEP	Q9H4A4	246	284	2	650	Chain	ID=PRO_0000095088;Note=Aminopeptidase B
RNPEP	Q9H4A4	363	401	2	650	Chain	ID=PRO_0000095088;Note=Aminopeptidase B
RNPEP	Q9H4A4	475	550	2	650	Chain	ID=PRO_0000095088;Note=Aminopeptidase B
RNPEP	Q9H4A4	246	284	262	262	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANKRD33B	A6NCL7	165	212	1	494	Chain	ID=PRO_0000328769;Note=Ankyrin repeat domain-containing protein 33B
ANKRD33B	A6NCL7	165	212	154	183	Repeat	Note=ANK 3
ANKRD33B	A6NCL7	165	212	189	218	Repeat	Note=ANK 4
ANO1	Q5XXA6	147	180	1	986	Chain	ID=PRO_0000288435;Note=Anoctamin-1
ANO1	Q5XXA6	321	365	1	986	Chain	ID=PRO_0000288435;Note=Anoctamin-1
ANO1	Q5XXA6	475	501	1	986	Chain	ID=PRO_0000288435;Note=Anoctamin-1
ANO1	Q5XXA6	147	180	1	333	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO1	Q5XXA6	321	365	1	333	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO1	Q5XXA6	321	365	334	354	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO1	Q5XXA6	321	365	355	402	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO1	Q5XXA6	475	501	424	519	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO1	Q5XXA6	475	501	476	501	Alternative sequence	ID=VSP_025669;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ANKRD29	Q8N6D5	241	274	1	301	Chain	ID=PRO_0000243903;Note=Ankyrin repeat domain-containing protein 29
ANKRD29	Q8N6D5	176	209	1	301	Chain	ID=PRO_0000243903;Note=Ankyrin repeat domain-containing protein 29
ANKRD29	Q8N6D5	110	143	1	301	Chain	ID=PRO_0000243903;Note=Ankyrin repeat domain-containing protein 29
ANKRD29	Q8N6D5	77	110	1	301	Chain	ID=PRO_0000243903;Note=Ankyrin repeat domain-containing protein 29
ANKRD29	Q8N6D5	44	77	1	301	Chain	ID=PRO_0000243903;Note=Ankyrin repeat domain-containing protein 29
ANKRD29	Q8N6D5	44	77	45	74	Repeat	Note=ANK 2
ANKRD29	Q8N6D5	77	110	78	107	Repeat	Note=ANK 3
ANKRD29	Q8N6D5	110	143	111	140	Repeat	Note=ANK 4
ANKRD29	Q8N6D5	176	209	177	206	Repeat	Note=ANK 6
ANKRD29	Q8N6D5	241	274	242	271	Repeat	Note=ANK 8
ANKRD29	Q8N6D5	241	274	242	274	Alternative sequence	ID=VSP_019488;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD29	Q8N6D5	77	110	95	95	Natural variant	ID=VAR_035610;Note=In a breast cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs767831283,PMID:16959974
ANKRD29	Q8N6D5	110	143	112	112	Natural variant	ID=VAR_026869;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855552,PMID:15489334
ANKRD31	Q8N7Z5	1801	1825	1	1873	Chain	ID=PRO_0000328839;Note=Putative ankyrin repeat domain-containing protein 31
ANKRD31	Q8N7Z5	1720	1767	1	1873	Chain	ID=PRO_0000328839;Note=Putative ankyrin repeat domain-containing protein 31
ANKRD31	Q8N7Z5	149	339	1	1873	Chain	ID=PRO_0000328839;Note=Putative ankyrin repeat domain-containing protein 31
ANKS1A	Q92625	269	303	2	1134	Chain	ID=PRO_0000066921;Note=Ankyrin repeat and SAM domain-containing protein 1A
ANKS1A	Q92625	945	969	2	1134	Chain	ID=PRO_0000066921;Note=Ankyrin repeat and SAM domain-containing protein 1A
ANKS1A	Q92625	998	1044	2	1134	Chain	ID=PRO_0000066921;Note=Ankyrin repeat and SAM domain-containing protein 1A
ANKS1A	Q92625	269	303	246	275	Repeat	Note=ANK 6
ANKS1A	Q92625	945	969	936	1091	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
ANKS1A	Q92625	998	1044	936	1091	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
ANKS1A	Q92625	945	969	321	1134	Alternative sequence	ID=VSP_056513;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKS1A	Q92625	998	1044	321	1134	Alternative sequence	ID=VSP_056513;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANO6	Q4KMQ2	436	462	1	910	Chain	ID=PRO_0000191757;Note=Anoctamin-6
ANO6	Q4KMQ2	436	462	397	454	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO6	Q4KMQ2	436	462	455	475	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO8	Q9HCE9	806	850	2	1232	Chain	ID=PRO_0000249003;Note=Anoctamin-8
ANO8	Q9HCE9	806	850	772	807	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO8	Q9HCE9	806	850	808	828	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO8	Q9HCE9	806	850	829	841	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO8	Q9HCE9	806	850	842	862	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD11	Q6UB99	2571	2602	1	2663	Chain	ID=PRO_0000066907;Note=Ankyrin repeat domain-containing protein 11
ANKRD11	Q6UB99	2490	2523	1	2663	Chain	ID=PRO_0000066907;Note=Ankyrin repeat domain-containing protein 11
ANKRD11	Q6UB99	2571	2602	1	2663	Chain	ID=PRO_0000066907;Note=Ankyrin repeat domain-containing protein 11
ANKRD11	Q6UB99	2490	2523	1	2663	Chain	ID=PRO_0000066907;Note=Ankyrin repeat domain-containing protein 11
ANKRD11	Q6UB99	2571	2602	2369	2663	Region	Note=Important for protein degradation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25413698;Dbxref=PMID:25413698
ANKRD11	Q6UB99	2490	2523	2369	2663	Region	Note=Important for protein degradation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25413698;Dbxref=PMID:25413698
ANKRD11	Q6UB99	2571	2602	2369	2663	Region	Note=Important for protein degradation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25413698;Dbxref=PMID:25413698
ANKRD11	Q6UB99	2490	2523	2369	2663	Region	Note=Important for protein degradation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25413698;Dbxref=PMID:25413698
ANKRD11	Q6UB99	2490	2523	2512	2512	Natural variant	ID=VAR_075870;Note=In KBGS%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25413698;Dbxref=PMID:25413698
ANKRD11	Q6UB99	2490	2523	2512	2512	Natural variant	ID=VAR_075870;Note=In KBGS%3B unknown pathological significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25413698;Dbxref=PMID:25413698
AP1M1	Q9BXS5	296	349	2	423	Chain	ID=PRO_0000193770;Note=AP-1 complex subunit mu-1
AP1M1	Q9BXS5	296	349	168	421	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP1M1	Q9BXS5	296	349	303	303	Natural variant	ID=VAR_036536;Note=In a breast cancer sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs999036825,PMID:16959974
AQP2	P41181	175	202	1	271	Chain	ID=PRO_0000063934;Note=Aquaporin-2
AQP2	P41181	175	202	157	176	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP2	P41181	175	202	177	202	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP2	P41181	175	202	184	186	Motif	Note=NPA 2
AQP2	P41181	175	202	175	175	Natural variant	ID=VAR_015248;Note=In ANDI. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12191971,ECO:0000269|PubMed:9550615,ECO:0000269|PubMed:9745427;Dbxref=dbSNP:rs104894335,PMID:12191971,PMID:9550615,PMID:9745427
AQP2	P41181	175	202	180	180	Natural variant	ID=VAR_062587;Note=In ANDI. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16845277;Dbxref=dbSNP:rs147039983,PMID:16845277
AQP2	P41181	175	202	181	181	Natural variant	ID=VAR_015249;Note=In ANDI. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9302264;Dbxref=dbSNP:rs104894337,PMID:9302264
AQP2	P41181	175	202	185	185	Natural variant	ID=VAR_015250;Note=In ANDI. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12191971;Dbxref=dbSNP:rs761713751,PMID:12191971
AQP2	P41181	175	202	187	187	Natural variant	ID=VAR_004402;Note=In ANDI%3B mutant protein does not fold properly and is not functional. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15509592,ECO:0000269|PubMed:7524315;Dbxref=dbSNP:rs104894328,PMID:15509592,PMID:7524315
AQP2	P41181	175	202	187	187	Natural variant	ID=VAR_062588;Note=In ANDI. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16361827;Dbxref=dbSNP:rs193922495,PMID:16361827
AQP2	P41181	175	202	190	190	Natural variant	ID=VAR_015251;Note=In ANDI%3B mutant protein does not fold properly and is not functional. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15509592,ECO:0000269|PubMed:9550615;Dbxref=dbSNP:rs104894341,PMID:15509592,PMID:9550615
AQP2	P41181	175	202	194	194	Natural variant	ID=VAR_015252;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12191971;Dbxref=dbSNP:rs772051028,PMID:12191971
AQP2	P41181	175	202	202	202	Natural variant	ID=VAR_015253;Note=In ANDI. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8882880;Dbxref=PMID:8882880
AQP2	P41181	175	202	159	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NEF
AQP2	P41181	175	202	185	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NEF
AQP2	P41181	175	202	199	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NEF
ATRAID	Q6UW56	74	97	31	229	Chain	ID=PRO_0000020752;Note=All-trans retinoic acid-induced differentiation factor
ATRAID	Q6UW56	98	121	31	229	Chain	ID=PRO_0000020752;Note=All-trans retinoic acid-induced differentiation factor
ATRAID	Q6UW56	74	97	31	199	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATRAID	Q6UW56	98	121	31	199	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATRAID	Q6UW56	74	97	79	79	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
AREL1	O15033	596	638	1	823	Chain	ID=PRO_0000120349;Note=Apoptosis-resistant E3 ubiquitin protein ligase 1
AREL1	O15033	536	596	1	823	Chain	ID=PRO_0000120349;Note=Apoptosis-resistant E3 ubiquitin protein ligase 1
AREL1	O15033	360	386	1	823	Chain	ID=PRO_0000120349;Note=Apoptosis-resistant E3 ubiquitin protein ligase 1
AREL1	O15033	596	638	483	823	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
AREL1	O15033	536	596	483	823	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
AREL1	O15033	360	386	373	373	Sequence conflict	Note=P->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARF4	P18085	110	152	2	180	Chain	ID=PRO_0000207391;Note=ADP-ribosylation factor 4
ARF4	P18085	86	110	2	180	Chain	ID=PRO_0000207391;Note=ADP-ribosylation factor 4
ARF4	P18085	110	152	126	129	Nucleotide binding	Note=GTP
ARF4	P18085	110	152	147	147	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARF4	P18085	86	110	83	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	86	110	97	99	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	110	152	100	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	86	110	100	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	110	152	114	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	110	152	120	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	110	152	136	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARF4	P18085	110	152	145	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Z6X
ARL15	Q9NXU5	64	84	1	204	Chain	ID=PRO_0000282387;Note=ADP-ribosylation factor-like protein 15
ARL15	Q9NXU5	64	84	82	86	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARL16	Q0P5N6	64	102	1	197	Chain	ID=PRO_0000264630;Note=ADP-ribosylation factor-like protein 16
ARL16	Q0P5N6	64	102	82	86	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
ARHGEF2	Q92974	406	489	1	986	Chain	ID=PRO_0000080909;Note=Rho guanine nucleotide exchange factor 2
ARHGEF2	Q92974	406	489	235	432	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF2	Q92974	406	489	472	571	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF2	Q92974	406	489	440	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ARHGEF2	Q92974	406	489	454	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ARHGEF2	Q92974	406	489	458	460	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ARHGEF2	Q92974	406	489	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ARHGEF2	Q92974	406	489	465	469	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ARHGEF2	Q92974	406	489	473	482	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ARHGEF2	Q92974	406	489	488	504	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EFX
ALPK2	Q86TB3	1876	1888	1	2170	Chain	ID=PRO_0000260030;Note=Alpha-protein kinase 2
ALPK2	Q86TB3	1876	1888	1884	1884	Natural variant	ID=VAR_057742;Note=R->C;Dbxref=dbSNP:rs33969768
ALPK3	Q96L96	1566	1578	1	1907	Chain	ID=PRO_0000260031;Note=Alpha-protein kinase 3
ALPK3	Q96L96	1566	1578	1261	1907	Natural variant	ID=VAR_079142;Note=In CMH27. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26846950;Dbxref=PMID:26846950
ALPK3	Q96L96	1566	1578	1264	1907	Natural variant	ID=VAR_079143;Note=In CMH27. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27106955;Dbxref=PMID:27106955
AMHR2	Q16671	77	141	18	573	Chain	ID=PRO_0000024408;Note=Anti-Muellerian hormone type-2 receptor
AMHR2	Q16671	141	167	18	573	Chain	ID=PRO_0000024408;Note=Anti-Muellerian hormone type-2 receptor
AMHR2	Q16671	77	141	18	149	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMHR2	Q16671	141	167	18	149	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMHR2	Q16671	141	167	150	170	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMHR2	Q16671	77	141	119	119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
AMHR2	Q16671	77	141	55	79	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P37023
AMHR2	Q16671	77	141	92	109	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P37023
AMHR2	Q16671	141	167	142	142	Natural variant	ID=VAR_015526;Note=In PMDS2. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8872466;Dbxref=PMID:8872466
AMHR2	Q16671	77	141	121	121	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMHR2	Q16671	141	167	161	161	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMY2A	P04746	171	248	16	511	Chain	ID=PRO_0000001397;Note=Pancreatic alpha-amylase
AMY2A	P04746	171	248	212	212	Active site	Note=Nucleophile;Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10091666,ECO:0000305|PubMed:10769135,ECO:0000305|PubMed:11914097;Dbxref=PMID:10091666,PMID:10769135,PMID:11914097
AMY2A	P04746	171	248	248	248	Active site	Note=Proton donor;Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:10091666,ECO:0000305|PubMed:10769135,ECO:0000305|PubMed:11772019,ECO:0000305|PubMed:11914097;Dbxref=PMID:10091666,PMID:10769135,PMID:11772019,PMID:11914097
AMY2A	P04746	171	248	173	173	Metal binding	Note=Calcium%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1HNY,ECO:0000269|PubMed:10091666,ECO:0000269|PubMed:10769135,ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:8528071;Dbxref=PMID:10091666,PMID:10769135,PMID:11772019,PMID:8528071
AMY2A	P04746	171	248	182	182	Metal binding	Note=Calcium;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1HNY,ECO:0000269|PubMed:10091666,ECO:0000269|PubMed:10769135,ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:8528071;Dbxref=PMID:10091666,PMID:10769135,PMID:11772019,PMID:8528071
AMY2A	P04746	171	248	216	216	Metal binding	Note=Calcium%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1HNY,ECO:0000269|PubMed:10091666,ECO:0000269|PubMed:10769135,ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:8528071;Dbxref=PMID:10091666,PMID:10769135,PMID:11772019,PMID:8528071
AMY2A	P04746	171	248	210	210	Binding site	Note=Chloride;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1HNY,ECO:0000269|PubMed:10091666,ECO:0000269|PubMed:10769135,ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:8528071;Dbxref=PMID:10091666,PMID:10769135,PMID:11772019,PMID:8528071
AMY2A	P04746	171	248	156	175	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1HNY,ECO:0000269|PubMed:10091666,ECO:0000269|PubMed:10769135,ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:8528071;Dbxref=PMID:10091666,PMID:10769135,PMID:11772019,PMID:8528071
AMY2A	P04746	171	248	210	210	Mutagenesis	Note=Abolishes chloride binding%3B strongly reduces activity. R->A%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11772019;Dbxref=PMID:11772019
AMY2A	P04746	171	248	212	212	Mutagenesis	Note=Abolishes activity. D->A%2CN;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10091666,ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:11914097;Dbxref=PMID:10091666,PMID:11772019,PMID:11914097
AMY2A	P04746	171	248	248	248	Mutagenesis	Note=Reduces activity. E->A%2CQ;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11772019,ECO:0000269|PubMed:11914097;Dbxref=PMID:11772019,PMID:11914097
AMY2A	P04746	171	248	169	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	177	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	180	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	188	204	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	208	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	214	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	219	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	234	236	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMY2A	P04746	171	248	244	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U3A
AMZ1	Q400G9	101	157	1	498	Chain	ID=PRO_0000159614;Note=Archaemetzincin-1
ANTXR1	Q9H6X2	317	349	33	564	Chain	ID=PRO_0000002692;Note=Anthrax toxin receptor 1
ANTXR1	Q9H6X2	363	395	33	564	Chain	ID=PRO_0000002692;Note=Anthrax toxin receptor 1
ANTXR1	Q9H6X2	317	349	33	321	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANTXR1	Q9H6X2	317	349	322	342	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANTXR1	Q9H6X2	317	349	343	564	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANTXR1	Q9H6X2	363	395	343	564	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANTXR1	Q9H6X2	363	395	360	368	Compositional bias	Note=Asp/Glu-rich (highly acidic)
ANTXR1	Q9H6X2	317	349	298	564	Alternative sequence	ID=VSP_000447;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANTXR1	Q9H6X2	363	395	298	564	Alternative sequence	ID=VSP_000447;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANTXR1	Q9H6X2	317	349	315	358	Alternative sequence	ID=VSP_047863;Note=In isoform 6. THCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPP->FHPSPSSPGSTSQQGTSSLPPSSKAFCLEPKVPALGSLRNFRRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22912819;Dbxref=PMID:22912819
ANTXR1	Q9H6X2	317	349	319	333	Alternative sequence	ID=VSP_000448;Note=In isoform 4. DGSILAIALLILFLL->LHKIASGPTTAACME;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ANTXR1	Q9H6X2	317	349	334	564	Alternative sequence	ID=VSP_000449;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ANTXR1	Q9H6X2	363	395	334	564	Alternative sequence	ID=VSP_000449;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ANTXR1	Q9H6X2	363	395	359	564	Alternative sequence	ID=VSP_047864;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22912819;Dbxref=PMID:22912819
ANTXR1	Q9H6X2	363	395	365	368	Alternative sequence	ID=VSP_000444;Note=In isoform 2. EDDD->NKIK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11700562;Dbxref=PMID:11700562
ANTXR1	Q9H6X2	363	395	369	564	Alternative sequence	ID=VSP_000445;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11700562;Dbxref=PMID:11700562
ANTXR1	Q9H6X2	317	349	326	326	Natural variant	ID=VAR_063146;Note=In HCI susceptibility%3B expression of FLT1 in hemangioma endothelial cells is markedly reduced compared to controls%3B low FLT1 expression in hemangioma cells is caused by reduced activity of a pathway involving ITGB1%2C ANTXR1%2C KDR and NFATC2IP%3B the mutation disrupts interaction of these molecules in a dominant-negative manner. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18931684;Dbxref=dbSNP:rs119475040,PMID:18931684
ANKRD7	Q92527	98	156	1	254	Chain	ID=PRO_0000066902;Note=Ankyrin repeat domain-containing protein 7
ANKRD7	Q92527	98	156	91	120	Repeat	Note=ANK 2
ANKRD7	Q92527	98	156	124	153	Repeat	Note=ANK 3
ANKRD7	Q92527	98	156	104	108	Sequence conflict	Note=NEDCA->MRIVP;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANKRD16	Q6P6B7	229	283	1	361	Chain	ID=PRO_0000240831;Note=Ankyrin repeat domain-containing protein 16
ANKRD16	Q6P6B7	229	283	1	361	Chain	ID=PRO_0000240831;Note=Ankyrin repeat domain-containing protein 16
ANKRD16	Q6P6B7	229	283	204	234	Repeat	Note=ANK 6
ANKRD16	Q6P6B7	229	283	204	234	Repeat	Note=ANK 6
ANKRD16	Q6P6B7	229	283	238	268	Repeat	Note=ANK 7
ANKRD16	Q6P6B7	229	283	238	268	Repeat	Note=ANK 7
ANKRD16	Q6P6B7	229	283	273	302	Repeat	Note=ANK 8
ANKRD16	Q6P6B7	229	283	273	302	Repeat	Note=ANK 8
ANKMY1	Q9P2S6	709	753	1	941	Chain	ID=PRO_0000066894;Note=Ankyrin repeat and MYND domain-containing protein 1
ANKMY1	Q9P2S6	673	709	1	941	Chain	ID=PRO_0000066894;Note=Ankyrin repeat and MYND domain-containing protein 1
ANKMY1	Q9P2S6	626	673	1	941	Chain	ID=PRO_0000066894;Note=Ankyrin repeat and MYND domain-containing protein 1
ANKMY1	Q9P2S6	673	709	657	691	Repeat	Note=ANK 5
ANKMY1	Q9P2S6	626	673	657	691	Repeat	Note=ANK 5
ANKMY1	Q9P2S6	709	753	694	723	Repeat	Note=ANK 6
ANKMY1	Q9P2S6	673	709	694	723	Repeat	Note=ANK 6
ANKMY1	Q9P2S6	709	753	737	766	Repeat	Note=ANK 7
ANKMY1	Q9P2S6	709	753	581	941	Alternative sequence	ID=VSP_007444;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKMY1	Q9P2S6	673	709	581	941	Alternative sequence	ID=VSP_007444;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKMY1	Q9P2S6	626	673	581	941	Alternative sequence	ID=VSP_007444;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKMY1	Q9P2S6	709	753	627	709	Alternative sequence	ID=VSP_007445;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKMY1	Q9P2S6	673	709	627	709	Alternative sequence	ID=VSP_007445;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKMY1	Q9P2S6	626	673	627	709	Alternative sequence	ID=VSP_007445;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKMY1	Q9P2S6	626	673	649	649	Natural variant	ID=VAR_048268;Note=T->M;Dbxref=dbSNP:rs35044862
ANXA9	O76027	184	204	1	345	Chain	ID=PRO_0000067505;Note=Annexin A9
ANXA9	O76027	232	264	1	345	Chain	ID=PRO_0000067505;Note=Annexin A9
ANXA9	O76027	284	325	1	345	Chain	ID=PRO_0000067505;Note=Annexin A9
ANXA9	O76027	184	204	199	264	Repeat	Note=Annexin 3
ANXA9	O76027	232	264	199	264	Repeat	Note=Annexin 3
ANXA9	O76027	284	325	272	339	Repeat	Note=Annexin 4
ANXA9	O76027	232	264	232	232	Natural variant	ID=VAR_048258;Note=R->Q;Dbxref=dbSNP:rs7542365
SNAP91	O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	591	615	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	385	441	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	255	269	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	591	615	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	385	441	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	255	269	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	643	671	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	615	643	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	591	615	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	565	591	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	441	477	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	385	441	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	255	269	1	907	Chain	ID=PRO_0000193864;Note=Clathrin coat assembly protein AP180
SNAP91	O60641	565	591	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	441	477	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	385	441	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	565	591	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	441	477	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	385	441	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	565	591	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	441	477	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	385	441	361	583	Compositional bias	Note=Ala-rich
SNAP91	O60641	591	615	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	591	615	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	591	615	596	596	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	591	615	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	591	615	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	591	615	602	602	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	615	643	623	623	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	615	643	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05140
SNAP91	O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	591	615	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	385	441	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	255	269	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	591	615	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	385	441	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	255	269	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	643	671	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	615	643	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	591	615	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	565	591	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	441	477	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	385	441	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	255	269	59	907	Alternative sequence	ID=VSP_020997;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
SNAP91	O60641	255	269	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	255	269	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	255	269	256	269	Alternative sequence	ID=VSP_020998;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	591	615	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	385	441	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	591	615	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	385	441	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	643	671	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	615	643	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	591	615	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	565	591	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	441	477	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	385	441	381	671	Alternative sequence	ID=VSP_021000;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SNAP91	O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNAP91	O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNAP91	O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNAP91	O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNAP91	O60641	643	671	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SNAP91	O60641	615	643	616	643	Alternative sequence	ID=VSP_047049;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
APBA3	O96018	465	505	1	575	Chain	ID=PRO_0000064620;Note=Amyloid-beta A4 precursor protein-binding family A member 3
APBA3	O96018	394	465	1	575	Chain	ID=PRO_0000064620;Note=Amyloid-beta A4 precursor protein-binding family A member 3
APBA3	O96018	283	337	1	575	Chain	ID=PRO_0000064620;Note=Amyloid-beta A4 precursor protein-binding family A member 3
APBA3	O96018	283	337	217	381	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBA3	O96018	465	505	394	480	Domain	Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
APBA3	O96018	394	465	394	480	Domain	Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
APBA3	O96018	465	505	485	560	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
APBA3	O96018	283	337	215	364	Region	Note=Required for interaction with NECAB3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26948053;Dbxref=PMID:26948053
APBA3	O96018	465	505	505	505	Sequence conflict	Note=I->IVRPRPLAPGWGGRAALSTAPEQPPPLSRAPLFLPQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
APBA3	O96018	394	465	393	398	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	394	465	407	411	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	394	465	415	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	394	465	421	426	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	394	465	433	435	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	394	465	443	449	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	465	505	457	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	394	465	457	466	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	465	505	467	469	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	465	505	470	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT7
APBA3	O96018	465	505	483	490	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT8
APBA3	O96018	465	505	493	495	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT8
APBA3	O96018	465	505	498	502	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT8
APBA3	O96018	465	505	505	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YT8
APEX2	Q9UBZ4	141	189	1	518	Chain	ID=PRO_0000200014;Note=DNA-(apurinic or apyrimidinic site) lyase 2
APEX2	Q9UBZ4	141	189	156	156	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
APEX2	Q9UBZ4	141	189	141	141	Natural variant	ID=VAR_023390;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs2301416
APEX2	Q9UBZ4	141	189	141	141	Natural variant	ID=VAR_048261;Note=R->W;Dbxref=dbSNP:rs2301416
AP1G2	O75843	719	752	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	543	577	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	470	500	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	364	410	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	326	363	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	247	274	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	215	247	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	719	752	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	543	577	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	470	500	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	364	410	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	326	363	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	247	274	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	215	247	1	785	Chain	ID=PRO_0000193760;Note=AP-1 complex subunit gamma-like 2
AP1G2	O75843	719	752	665	780	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
AP1G2	O75843	719	752	665	780	Domain	Note=GAE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00093
AP1G2	O75843	364	410	369	379	Region	Note=Essential for ubiquitin-binding
AP1G2	O75843	364	410	369	379	Region	Note=Essential for ubiquitin-binding
AP1G2	O75843	364	410	377	377	Natural variant	ID=VAR_024363;Note=S->F;Dbxref=dbSNP:rs12897422
AP1G2	O75843	364	410	377	377	Natural variant	ID=VAR_024363;Note=S->F;Dbxref=dbSNP:rs12897422
AP1G2	O75843	364	410	369	369	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-372. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	369	369	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-372. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	372	372	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-369. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	372	372	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-369. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	372	372	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-376. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	372	372	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-376. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	376	376	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-372. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	376	376	Mutagenesis	Note=Greatly diminishes interaction with ubiquitin%3B when associated with G-372. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16867982;Dbxref=PMID:16867982
AP1G2	O75843	364	410	399	399	Sequence conflict	Note=A->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP1G2	O75843	364	410	399	399	Sequence conflict	Note=A->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP1G2	O75843	364	410	402	402	Sequence conflict	Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP1G2	O75843	364	410	402	402	Sequence conflict	Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP1G2	O75843	719	752	721	725	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHF
AP1G2	O75843	719	752	721	725	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHF
AP1G2	O75843	719	752	731	733	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9G
AP1G2	O75843	719	752	731	733	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2E9G
AP1G2	O75843	719	752	735	737	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHF
AP1G2	O75843	719	752	735	737	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHF
AP1G2	O75843	719	752	741	748	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHF
AP1G2	O75843	719	752	741	748	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZHF
AQP11	Q8NBQ7	206	245	1	271	Chain	ID=PRO_0000063968;Note=Aquaporin-11
AQP11	Q8NBQ7	206	245	195	215	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP11	Q8NBQ7	206	245	235	255	Transmembrane	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP11	Q8NBQ7	206	245	216	218	Motif	Note=NPA 2
AQP5	P55064	176	204	1	265	Chain	ID=PRO_0000063951;Note=Aquaporin-5
AQP5	P55064	176	204	162	182	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP5	P55064	176	204	183	205	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP5	P55064	176	204	185	187	Motif	Note=NPA 2
AQP5	P55064	176	204	177	177	Natural variant	ID=VAR_070445;Note=In PPKB%3B retains the ability to traffic to the cell membrane. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830519;Dbxref=dbSNP:rs398123056,PMID:23830519
AQP5	P55064	176	204	188	188	Natural variant	ID=VAR_070446;Note=In PPKB%3B retains the ability to traffic to the cell membrane. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830519;Dbxref=dbSNP:rs368292687,PMID:23830519
AQP5	P55064	176	204	161	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9S
AQP5	P55064	176	204	186	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9S
AQP5	P55064	176	204	203	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D9S
APH1B	Q8WW43	118	159	1	257	Chain	ID=PRO_0000221052;Note=Gamma-secretase subunit APH-1B
APH1B	Q8WW43	118	159	115	135	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
APH1B	Q8WW43	118	159	158	178	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
APH1B	Q8WW43	118	159	119	159	Alternative sequence	ID=VSP_042945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15823552;Dbxref=PMID:15823552
AP3D1	O14617	917	933	2	1153	Chain	ID=PRO_0000193766;Note=AP-3 complex subunit delta-1
AP3D1	O14617	667	691	2	1153	Chain	ID=PRO_0000193766;Note=AP-3 complex subunit delta-1
AP3D1	O14617	118	154	2	1153	Chain	ID=PRO_0000193766;Note=AP-3 complex subunit delta-1
AP3D1	O14617	91	118	2	1153	Chain	ID=PRO_0000193766;Note=AP-3 complex subunit delta-1
AP3D1	O14617	64	91	2	1153	Chain	ID=PRO_0000193766;Note=AP-3 complex subunit delta-1
AP3D1	O14617	64	91	34	71	Repeat	Note=HEAT 1
AP3D1	O14617	91	118	77	114	Repeat	Note=HEAT 2
AP3D1	O14617	64	91	77	114	Repeat	Note=HEAT 2
AP3D1	O14617	118	154	142	179	Repeat	Note=HEAT 3
AP3D1	O14617	667	691	659	679	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AP3D1	O14617	667	691	688	688	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
AP3D1	O14617	118	154	117	285	Alternative sequence	ID=VSP_000167;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9303295;Dbxref=PMID:9303295
AP3D1	O14617	91	118	117	285	Alternative sequence	ID=VSP_000167;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9303295;Dbxref=PMID:9303295
ARMC1	Q9NVT9	155	194	1	282	Chain	ID=PRO_0000240882;Note=Armadillo repeat-containing protein 1
ARMC1	Q9NVT9	155	194	189	189	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARMC1	Q9NVT9	155	194	54	155	Alternative sequence	ID=VSP_054646;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARNT2	Q9HBZ2	49	64	1	717	Chain	ID=PRO_0000127122;Note=Aryl hydrocarbon receptor nuclear translocator 2
ARNT2	Q9HBZ2	49	64	63	116	Domain	Note=bHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981
AP2S1	P53680	89	109	1	142	Chain	ID=PRO_0000193804;Note=AP-2 complex subunit sigma
AP2S1	P53680	51	89	1	142	Chain	ID=PRO_0000193804;Note=AP-2 complex subunit sigma
AP2S1	P53680	1	51	1	142	Chain	ID=PRO_0000193804;Note=AP-2 complex subunit sigma
AP2S1	P53680	89	109	52	89	Alternative sequence	ID=VSP_017352;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9767099;Dbxref=PMID:9767099
AP2S1	P53680	51	89	52	89	Alternative sequence	ID=VSP_017352;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9767099;Dbxref=PMID:9767099
AP2S1	P53680	1	51	15	15	Natural variant	ID=VAR_069570;Note=In HHC3%3B there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type%2C indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23222959,ECO:0000269|PubMed:24081735;Dbxref=dbSNP:rs397514498,PMID:23222959,PMID:24081735
AP2S1	P53680	1	51	15	15	Natural variant	ID=VAR_069571;Note=In HHC3%3B there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type%2C indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23222959;Dbxref=dbSNP:rs397514499,PMID:23222959
AP2S1	P53680	1	51	15	15	Natural variant	ID=VAR_069572;Note=In HHC3%3B there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type%2C indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23222959,ECO:0000269|PubMed:24081735;Dbxref=dbSNP:rs397514499,PMID:23222959,PMID:24081735
AP2S1	P53680	51	89	77	77	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP2S1	P53680	51	89	77	77	Sequence conflict	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP2S1	P53680	51	89	83	83	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP2S1	P53680	51	89	83	83	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LPA	P08519	1865	1911	20	4548	Chain	ID=PRO_0000028097;Note=Apolipoprotein(a)
LPA	P08519	1865	1911	20	4548	Chain	ID=PRO_0000028097;Note=Apolipoprotein(a)
LPA	P08519	1865	1911	1841	1954	Domain	Note=Kringle 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00121
LPA	P08519	1865	1911	1841	1954	Domain	Note=Kringle 17;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00121
LPA	P08519	1865	1911	1852	1929	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LPA	P08519	1865	1911	1852	1929	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LPA	P08519	1865	1911	1873	1912	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LPA	P08519	1865	1911	1873	1912	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LPA	P08519	1865	1911	1901	1924	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
LPA	P08519	1865	1911	1901	1924	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
AQP8	O94778	201	245	1	261	Chain	ID=PRO_0000063961;Note=Aquaporin-8
AQP8	O94778	201	245	184	204	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP8	O94778	201	245	205	228	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP8	O94778	201	245	229	249	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
AQP8	O94778	201	245	210	212	Motif	Note=NPA 2
AQP8	O94778	201	245	229	229	Natural variant	ID=VAR_036484;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
AQR	O60306	1055	1079	1	1485	Chain	ID=PRO_0000252389;Note=RNA helicase aquarius
AQR	O60306	1009	1055	1	1485	Chain	ID=PRO_0000252389;Note=RNA helicase aquarius
AQR	O60306	748	796	1	1485	Chain	ID=PRO_0000252389;Note=RNA helicase aquarius
AQR	O60306	110	157	1	1485	Chain	ID=PRO_0000252389;Note=RNA helicase aquarius
AQR	O60306	110	157	1	416	Region	Note=Helical region with structural similarity to ARM repeat domains;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25599396;Dbxref=PMID:25599396
AQR	O60306	1055	1079	417	1485	Region	Note=Required for assembly of the IB complex;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25599396;Dbxref=PMID:25599396
AQR	O60306	1009	1055	417	1485	Region	Note=Required for assembly of the IB complex;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25599396;Dbxref=PMID:25599396
AQR	O60306	748	796	417	1485	Region	Note=Required for assembly of the IB complex;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25599396;Dbxref=PMID:25599396
AQR	O60306	1009	1055	1051	1051	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
AQR	O60306	1009	1055	1026	1026	Sequence conflict	Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
AQR	O60306	110	157	110	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	110	157	119	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	110	157	136	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	110	157	140	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	110	157	155	158	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	748	796	745	750	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	748	796	775	781	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	748	796	791	793	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1009	1055	987	1011	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1009	1055	1013	1016	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1009	1055	1020	1029	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1009	1055	1033	1038	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1009	1055	1039	1052	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1055	1079	1057	1063	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1055	1079	1064	1066	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1055	1079	1069	1073	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
AQR	O60306	1055	1079	1074	1077	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PJ3
ARL13B	Q3SXY8	380	403	1	428	Chain	ID=PRO_0000251137;Note=ADP-ribosylation factor-like protein 13B
ARL13B	Q3SXY8	380	403	1	428	Chain	ID=PRO_0000251137;Note=ADP-ribosylation factor-like protein 13B
ARL13B	Q3SXY8	380	403	369	419	Compositional bias	Note=Pro-rich
ARL13B	Q3SXY8	380	403	369	419	Compositional bias	Note=Pro-rich
ARL13B	Q3SXY8	380	403	390	390	Natural variant	ID=VAR_069190;Note=In a nephronophthisis (NPHP) patient. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21068128;Dbxref=PMID:21068128
ARL13B	Q3SXY8	380	403	390	390	Natural variant	ID=VAR_069190;Note=In a nephronophthisis (NPHP) patient. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21068128;Dbxref=PMID:21068128
ARFIP1	P53367	67	99	2	373	Chain	ID=PRO_0000064665;Note=Arfaptin-1
ARFIP1	P53367	67	99	2	373	Chain	ID=PRO_0000064665;Note=Arfaptin-1
ARFIP1	P53367	67	99	69	69	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
ARFIP1	P53367	67	99	69	69	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
ARFIP1	P53367	67	99	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ARFIP1	P53367	67	99	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ARFIP1	P53367	67	99	32	211	Alternative sequence	ID=VSP_057425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFIP1	P53367	67	99	32	211	Alternative sequence	ID=VSP_057425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFIP1	P53367	67	99	69	100	Alternative sequence	ID=VSP_004088;Note=In isoform A. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9038142;Dbxref=PMID:14702039,PMID:15489334,PMID:9038142
ARFIP1	P53367	67	99	69	100	Alternative sequence	ID=VSP_004088;Note=In isoform A. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9038142;Dbxref=PMID:14702039,PMID:15489334,PMID:9038142
ARFIP2	P53365	105	179	1	341	Chain	ID=PRO_0000064667;Note=Arfaptin-2
ARFIP2	P53365	105	179	1	341	Chain	ID=PRO_0000064667;Note=Arfaptin-2
ARFIP2	P53365	105	179	121	321	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ARFIP2	P53365	105	179	121	321	Domain	Note=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
ARFIP2	P53365	105	179	1	105	Alternative sequence	ID=VSP_042524;Note=In isoform 2. MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYK->MKPALCLVAMGALVMDSSPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFIP2	P53365	105	179	1	105	Alternative sequence	ID=VSP_042524;Note=In isoform 2. MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYK->MKPALCLVAMGALVMDSSPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARFIP2	P53365	105	179	124	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I4D
ARFIP2	P53365	105	179	124	173	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I4D
ARFIP2	P53365	105	179	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I4D
ARFIP2	P53365	105	179	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I4D
ARFIP2	P53365	105	179	179	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I4D
ARFIP2	P53365	105	179	179	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1I4D
ARHGEF4	Q9NR80	308	368	1	690	Chain	ID=PRO_0000080914;Note=Rho guanine nucleotide exchange factor 4
ARHGEF4	Q9NR80	489	533	1	690	Chain	ID=PRO_0000080914;Note=Rho guanine nucleotide exchange factor 4
ARHGEF4	Q9NR80	614	640	1	690	Chain	ID=PRO_0000080914;Note=Rho guanine nucleotide exchange factor 4
ARHGEF4	Q9NR80	308	368	284	468	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF4	Q9NR80	489	533	499	606	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF4	Q9NR80	308	368	281	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	308	368	311	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	308	368	318	320	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	308	368	323	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	308	368	333	350	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	308	368	353	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DX1
ARHGEF4	Q9NR80	308	368	356	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	308	368	362	367	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	489	533	493	496	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	489	533	500	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	489	533	511	513	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	489	533	516	524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARHGEF4	Q9NR80	489	533	527	533	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PZ1
ARID1B	Q8NFD5	579	629	2	2236	Chain	ID=PRO_0000200576;Note=AT-rich interactive domain-containing protein 1B
ARID1B	Q8NFD5	747	777	2	2236	Chain	ID=PRO_0000200576;Note=AT-rich interactive domain-containing protein 1B
ARID1B	Q8NFD5	777	837	2	2236	Chain	ID=PRO_0000200576;Note=AT-rich interactive domain-containing protein 1B
ARID1B	Q8NFD5	579	629	574	633	Compositional bias	Note=Gln-rich
ARID1B	Q8NFD5	747	777	684	771	Compositional bias	Note=Ser-rich
ARID1B	Q8NFD5	579	629	1	750	Alternative sequence	ID=VSP_040800;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11734557;Dbxref=PMID:11734557
ARID1B	Q8NFD5	747	777	1	750	Alternative sequence	ID=VSP_040800;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11734557;Dbxref=PMID:11734557
ARID1B	Q8NFD5	579	629	579	579	Alternative sequence	ID=VSP_015226;Note=In isoform 2. Q->QDSGDATWKETFWL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11988099;Dbxref=PMID:11988099
ARID1B	Q8NFD5	747	777	771	771	Natural variant	ID=VAR_077456;Note=Found in a patient with short stature%3B unknown pathological significance. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26376624;Dbxref=PMID:26376624
ARID1B	Q8NFD5	777	837	814	814	Natural variant	ID=VAR_036257;Note=In a breast cancer sample%3B somatic mutation. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
ARID4A	P29374	2	39	1	1257	Chain	ID=PRO_0000200580;Note=AT-rich interactive domain-containing protein 4A
ARID4A	P29374	693	1070	1	1257	Chain	ID=PRO_0000200580;Note=AT-rich interactive domain-containing protein 4A
ARID4A	P29374	1105	1174	1	1257	Chain	ID=PRO_0000200580;Note=AT-rich interactive domain-containing protein 4A
ARID4A	P29374	1174	1223	1	1257	Chain	ID=PRO_0000200580;Note=AT-rich interactive domain-containing protein 4A
ARID4A	P29374	2	39	4	121	Region	Note=DNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24379399;Dbxref=PMID:24379399
ARID4A	P29374	693	1070	951	964	Region	Note=Retinoblastoma protein binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
ARID4A	P29374	693	1070	716	716	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARID4A	P29374	693	1070	864	864	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARID4A	P29374	1105	1174	1109	1109	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
ARID4A	P29374	1105	1174	1145	1145	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ARID4A	P29374	693	1070	718	718	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
ARID4A	P29374	693	1070	738	738	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ARID4A	P29374	693	1070	759	759	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ARID4A	P29374	1105	1174	1106	1174	Alternative sequence	ID=VSP_004371;Note=In isoform III. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8455946;Dbxref=PMID:8455946
ARID4A	P29374	1174	1223	1106	1174	Alternative sequence	ID=VSP_004371;Note=In isoform III. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8455946;Dbxref=PMID:8455946
ARID4A	P29374	1105	1174	1121	1174	Alternative sequence	ID=VSP_004373;Note=In isoform II. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8455946;Dbxref=PMID:8455946
ARID4A	P29374	1174	1223	1121	1174	Alternative sequence	ID=VSP_004373;Note=In isoform II. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8455946;Dbxref=PMID:8455946
ARID4A	P29374	1174	1223	1175	1175	Alternative sequence	ID=VSP_004372;Note=In isoform III. N->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8455946;Dbxref=PMID:8455946
ARID4A	P29374	693	1070	724	724	Natural variant	ID=VAR_031567;Note=N->S;Dbxref=dbSNP:rs2230098
ARID4A	P29374	693	1070	779	779	Natural variant	ID=VAR_031568;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8414517;Dbxref=dbSNP:rs1051858,PMID:8414517
ARID4A	P29374	1174	1223	1178	1178	Sequence conflict	Note=D->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARID4A	P29374	1174	1223	1196	1201	Sequence conflict	Note=IRKYYM->SENIICL;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARID4A	P29374	2	39	8	10	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MAM
ARID4A	P29374	2	39	15	20	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MAM
ARID4A	P29374	2	39	23	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MAM
APH1A	Q96BI3	119	160	1	265	Chain	ID=PRO_0000221050;Note=Gamma-secretase subunit APH-1A
APH1A	Q96BI3	119	160	119	139	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26280335;Dbxref=PMID:26280335
APH1A	Q96BI3	119	160	140	158	Topological domain	Note=Lumenal;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:26280335,ECO:0000305|PubMed:14593096;Dbxref=PMID:26280335,PMID:14593096
APH1A	Q96BI3	119	160	159	179	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26280335;Dbxref=PMID:26280335
APH1A	Q96BI3	119	160	39	120	Alternative sequence	ID=VSP_045424;Note=In isoform 3. AFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV->RCSALPTTSCLI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
APH1A	Q96BI3	119	160	114	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
APH1A	Q96BI3	119	160	156	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5A63
TFAP2A	P05549	15	160	1	437	Chain	ID=PRO_0000184796;Note=Transcription factor AP-2-alpha
TFAP2A	P05549	15	160	57	62	Motif	Note=PPxY motif
TFAP2A	P05549	15	160	29	117	Compositional bias	Note=Gln/Pro-rich (transactivation domain)
TFAP2A	P05549	15	160	1	15	Alternative sequence	ID=VSP_043268;Note=In isoform 2. MLWKLTDNIKYEDCE->MLVHSFSAM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TFAP2A	P05549	15	160	1	15	Alternative sequence	ID=VSP_047050;Note=In isoform 5. MLWKLTDNIKYEDCE->MSILAKMGDWQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGEF40	Q8TER5	639	678	1	1519	Chain	ID=PRO_0000314822;Note=Rho guanine nucleotide exchange factor 40
ARHGEF40	Q8TER5	832	880	1	1519	Chain	ID=PRO_0000314822;Note=Rho guanine nucleotide exchange factor 40
ARHGEF40	Q8TER5	1191	1263	1	1519	Chain	ID=PRO_0000314822;Note=Rho guanine nucleotide exchange factor 40
ARHGEF40	Q8TER5	1379	1414	1	1519	Chain	ID=PRO_0000314822;Note=Rho guanine nucleotide exchange factor 40
ARHGEF40	Q8TER5	1414	1462	1	1519	Chain	ID=PRO_0000314822;Note=Rho guanine nucleotide exchange factor 40
ARHGEF40	Q8TER5	1191	1263	1085	1253	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF40	Q8TER5	832	880	828	871	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ARHGEF40	Q8TER5	1414	1462	1433	1433	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ARHGEF40	Q8TER5	1414	1462	1438	1438	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ARHGEF40	Q8TER5	639	678	1	714	Alternative sequence	ID=VSP_030381;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGEF40	Q8TER5	1414	1462	1415	1519	Alternative sequence	ID=VSP_030382;Note=In isoform 3. AARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL->GEGQGAGGWPPGVKTLTMRIQRGGMVESQERHLVPKSVGLAGRPSVRLRVIPGSQEGFPTPAPHPPLPTLCSRPHPGLRGRVIL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ARHGEF40	Q8TER5	1414	1462	1415	1462	Alternative sequence	ID=VSP_030383;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ARHGEF40	Q8TER5	1414	1462	1418	1418	Natural variant	ID=VAR_060541;Note=T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17855344,PMID:15489334
ADPRHL1	Q8NDY3	168	215	1	354	Chain	ID=PRO_0000277606;Note=[Protein ADP-ribosylarginine] hydrolase-like protein 1
ARHGEF1	Q92888	75	108	1	912	Chain	ID=PRO_0000080906;Note=Rho guanine nucleotide exchange factor 1
ARHGEF1	Q92888	280	292	1	912	Chain	ID=PRO_0000080906;Note=Rho guanine nucleotide exchange factor 1
ARHGEF1	Q92888	499	541	1	912	Chain	ID=PRO_0000080906;Note=Rho guanine nucleotide exchange factor 1
ARHGEF1	Q92888	750	778	1	912	Chain	ID=PRO_0000080906;Note=Rho guanine nucleotide exchange factor 1
ARHGEF1	Q92888	75	108	41	232	Domain	Note=RGSL
ARHGEF1	Q92888	499	541	416	605	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF1	Q92888	750	778	647	760	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ARHGEF1	Q92888	75	108	76	108	Alternative sequence	ID=VSP_008125;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ARHGEF1	Q92888	750	778	752	752	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGEF1	Q92888	750	778	776	776	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ARHGEF1	Q92888	75	108	73	84	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IAP
ARHGEF1	Q92888	75	108	89	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IAP
ARHGEF1	Q92888	499	541	493	500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6A
ARHGEF1	Q92888	499	541	502	517	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6A
ARHGEF1	Q92888	499	541	519	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6A
ARHGEF1	Q92888	499	541	534	544	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6A
ARHGEF1	Q92888	750	778	745	760	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P6A
NET1	Q7Z628	65	85	1	596	Chain	ID=PRO_0000080924;Note=Neuroepithelial cell-transforming gene 1 protein
NET1	Q7Z628	85	121	1	596	Chain	ID=PRO_0000080924;Note=Neuroepithelial cell-transforming gene 1 protein
NET1	Q7Z628	177	198	1	596	Chain	ID=PRO_0000080924;Note=Neuroepithelial cell-transforming gene 1 protein
NET1	Q7Z628	177	198	174	356	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
NET1	Q7Z628	65	85	1	74	Region	Note=Necessary for nuclear localization;Ontology_term=ECO:0000250;evidence=ECO:0000250
NET1	Q7Z628	65	85	66	72	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250
NET1	Q7Z628	85	121	100	100	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
NET1	Q7Z628	85	121	106	106	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
NET1	Q7Z628	65	85	55	85	Alternative sequence	ID=VSP_011620;Note=In isoform 2. LTPGPNWDFTLKRKRREKDDDVVSLSSLDLK->MVAHDETGGLLPIKRTIRVLDVNNQSFREQE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8649828;Dbxref=PMID:15489334,PMID:8649828
NET1	Q7Z628	85	121	55	85	Alternative sequence	ID=VSP_011620;Note=In isoform 2. LTPGPNWDFTLKRKRREKDDDVVSLSSLDLK->MVAHDETGGLLPIKRTIRVLDVNNQSFREQE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8649828;Dbxref=PMID:15489334,PMID:8649828
NET1	Q7Z628	177	198	170	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XH9
ARHGEF17	Q96PE2	1090	1151	1	2063	Chain	ID=PRO_0000286589;Note=Rho guanine nucleotide exchange factor 17
ARHGEF17	Q96PE2	1151	1190	1	2063	Chain	ID=PRO_0000286589;Note=Rho guanine nucleotide exchange factor 17
ARHGEF17	Q96PE2	1749	1777	1	2063	Chain	ID=PRO_0000286589;Note=Rho guanine nucleotide exchange factor 17
ARHGEF17	Q96PE2	1090	1151	1066	1254	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ARHGEF17	Q96PE2	1151	1190	1066	1254	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
ADAM22	Q9P0K1	226	251	223	906	Chain	ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22
ADAM22	Q9P0K1	767	802	223	906	Chain	ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22
ADAM22	Q9P0K1	226	251	223	736	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM22	Q9P0K1	767	802	758	906	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM22	Q9P0K1	226	251	239	438	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM22	Q9P0K1	767	802	768	803	Alternative sequence	ID=VSP_005482;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11050470,ECO:0000303|PubMed:9693107,ECO:0000303|Ref.3;Dbxref=PMID:11050470,PMID:9693107
ADAM22	Q9P0K1	226	251	235	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C
ADAM22	Q9P0K1	226	251	239	247	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C
ADAM22	Q9P0K1	226	251	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C
AGAP1	Q9UPQ3	179	224	1	857	Chain	ID=PRO_0000074218;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 1
AGAP1	Q9UPQ3	267	319	1	857	Chain	ID=PRO_0000074218;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 1
AGAP1	Q9UPQ3	350	385	1	857	Chain	ID=PRO_0000074218;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 1
AGAP1	Q9UPQ3	441	494	1	857	Chain	ID=PRO_0000074218;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 1
AGAP1	Q9UPQ3	494	548	1	857	Chain	ID=PRO_0000074218;Note=Arf-GAP with GTPase%2C ANK repeat and PH domain-containing protein 1
AGAP1	Q9UPQ3	350	385	346	588	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AGAP1	Q9UPQ3	441	494	346	588	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AGAP1	Q9UPQ3	494	548	346	588	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AGAP1	Q9UPQ3	179	224	178	181	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGAP1	Q9UPQ3	179	224	66	276	Region	Note=Small GTPase-like
AGAP1	Q9UPQ3	267	319	66	276	Region	Note=Small GTPase-like
AGAP1	Q9UPQ3	494	548	521	521	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
AGAP1	Q9UPQ3	350	385	352	405	Alternative sequence	ID=VSP_011181;Note=In isoform 3. MLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKV->LPFFVLALTASTYLRPAGARARQSSPWPGPRGGQTSPHCAEGPQSAQLSGAMMN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGAP1	Q9UPQ3	441	494	406	857	Alternative sequence	ID=VSP_011182;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGAP1	Q9UPQ3	494	548	406	857	Alternative sequence	ID=VSP_011182;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGAP1	Q9UPQ3	441	494	442	494	Alternative sequence	ID=VSP_011183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:12640130,ECO:0000303|Ref.2;Dbxref=PMID:10470851,PMID:12640130
AGAP1	Q9UPQ3	494	548	442	494	Alternative sequence	ID=VSP_011183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:12640130,ECO:0000303|Ref.2;Dbxref=PMID:10470851,PMID:12640130
AGAP1	Q9UPQ3	267	319	288	288	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
AGAP1	Q9UPQ3	267	319	288	288	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
AGAP1	Q9UPQ3	267	319	288	288	Sequence conflict	Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
AHRR	A9YTQ3	121	151	1	701	Chain	ID=PRO_0000333857;Note=Aryl hydrocarbon receptor repressor
AHRR	A9YTQ3	121	151	112	182	Domain	Note=PAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
AHRR	A9YTQ3	121	151	117	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y7Y
AHRR	A9YTQ3	121	151	123	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y7Y
AHRR	A9YTQ3	121	151	134	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y7Y
AHRR	A9YTQ3	121	151	143	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y7Y
AHRR	A9YTQ3	121	151	151	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5Y7Y
ALDOA	P04075	180	208	2	364	Chain	ID=PRO_0000216936;Note=Fructose-bisphosphate aldolase A
ALDOA	P04075	180	208	2	364	Chain	ID=PRO_0000216936;Note=Fructose-bisphosphate aldolase A
ALDOA	P04075	180	208	2	364	Chain	ID=PRO_0000216936;Note=Fructose-bisphosphate aldolase A
ALDOA	P04075	180	208	2	364	Chain	ID=PRO_0000216936;Note=Fructose-bisphosphate aldolase A
ALDOA	P04075	180	208	188	188	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDOA	P04075	180	208	188	188	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDOA	P04075	180	208	188	188	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDOA	P04075	180	208	188	188	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDOA	P04075	180	208	207	207	Natural variant	ID=VAR_044142;Note=In GSD12%3B reduces thermal stability%3B 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14766013,ECO:0000269|PubMed:8598869;Dbxref=dbSNP:rs121909534,PMID:14766013,PMID:8598869
ALDOA	P04075	180	208	207	207	Natural variant	ID=VAR_044142;Note=In GSD12%3B reduces thermal stability%3B 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14766013,ECO:0000269|PubMed:8598869;Dbxref=dbSNP:rs121909534,PMID:14766013,PMID:8598869
ALDOA	P04075	180	208	207	207	Natural variant	ID=VAR_044142;Note=In GSD12%3B reduces thermal stability%3B 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14766013,ECO:0000269|PubMed:8598869;Dbxref=dbSNP:rs121909534,PMID:14766013,PMID:8598869
ALDOA	P04075	180	208	207	207	Natural variant	ID=VAR_044142;Note=In GSD12%3B reduces thermal stability%3B 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14766013,ECO:0000269|PubMed:8598869;Dbxref=dbSNP:rs121909534,PMID:14766013,PMID:8598869
ALDOA	P04075	180	208	180	180	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	180	180	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	180	180	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	180	180	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	196	196	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	196	196	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	196	196	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	196	196	Sequence conflict	Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDOA	P04075	180	208	161	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	161	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	161	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	161	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	184	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	184	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	184	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	184	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	199	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	199	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	199	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALDOA	P04075	180	208	199	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KY6
ALG12	Q9BV10	98	156	1	488	Chain	ID=PRO_0000215781;Note=Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1%2C6-mannosyltransferase
ALG12	Q9BV10	98	156	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG12	Q9BV10	98	156	122	142	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG12	Q9BV10	98	156	145	165	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG12	Q9BV10	98	156	101	101	Natural variant	ID=VAR_038428;Note=In CDG1G. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17506107;Dbxref=dbSNP:rs121907933,PMID:17506107
ALG12	Q9BV10	98	156	142	142	Natural variant	ID=VAR_017905;Note=In CDG1G. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11983712;Dbxref=dbSNP:rs28942090,PMID:11983712
ALG12	Q9BV10	98	156	146	146	Natural variant	ID=VAR_017906;Note=In CDG1G. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12217961,ECO:0000269|PubMed:17506107;Dbxref=dbSNP:rs121907932,PMID:12217961,PMID:17506107
ANKRD13C	Q8N6S4	432	464	1	541	Chain	ID=PRO_0000240645;Note=Ankyrin repeat domain-containing protein 13C
ANKRD13C	Q8N6S4	351	405	1	541	Chain	ID=PRO_0000240645;Note=Ankyrin repeat domain-containing protein 13C
ANKRD13C	Q8N6S4	307	351	1	541	Chain	ID=PRO_0000240645;Note=Ankyrin repeat domain-containing protein 13C
ANKRD13C	Q8N6S4	157	192	1	541	Chain	ID=PRO_0000240645;Note=Ankyrin repeat domain-containing protein 13C
ANKRD13C	Q8N6S4	157	192	143	172	Repeat	Note=ANK 2
ANKRD13C	Q8N6S4	157	192	176	205	Repeat	Note=ANK 3
ANKRD13C	Q8N6S4	432	464	148	541	Alternative sequence	ID=VSP_019407;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD13C	Q8N6S4	351	405	148	541	Alternative sequence	ID=VSP_019407;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD13C	Q8N6S4	307	351	148	541	Alternative sequence	ID=VSP_019407;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD13C	Q8N6S4	157	192	148	541	Alternative sequence	ID=VSP_019407;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD13C	Q8N6S4	157	192	158	193	Alternative sequence	ID=VSP_019408;Note=In isoform 2. ECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMI->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11230166;Dbxref=PMID:11230166
ANKRD13C	Q8N6S4	351	405	369	369	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANKRD18A	Q8IVF6	618	668	1	992	Chain	ID=PRO_0000066912;Note=Ankyrin repeat domain-containing protein 18A
ANKRD18A	Q8IVF6	618	668	378	618	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD18A	Q8IVF6	618	668	1	879	Alternative sequence	ID=VSP_056912;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD18B	A2A2Z9	107	165	1	1011	Chain	ID=PRO_0000317245;Note=Ankyrin repeat domain-containing protein 18B
ANKRD18B	A2A2Z9	201	246	1	1011	Chain	ID=PRO_0000317245;Note=Ankyrin repeat domain-containing protein 18B
ANKRD18B	A2A2Z9	107	165	100	129	Repeat	Note=ANK 2
ANKRD18B	A2A2Z9	107	165	133	162	Repeat	Note=ANK 3
ANKRD18B	A2A2Z9	201	246	199	228	Repeat	Note=ANK 5
ANKRD30B	Q9BXX2	206	251	1	1392	Chain	ID=PRO_0000416039;Note=Ankyrin repeat domain-containing protein 30B
ANKRD30B	Q9BXX2	206	251	204	233	Repeat	Note=ANK 5
ANKRD30B	Q9BXX2	206	251	248	248	Sequence conflict	Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANP32A	P39687	68	109	1	249	Chain	ID=PRO_0000137592;Note=Acidic leucine-rich nuclear phosphoprotein 32 family member A
ANP32A	P39687	68	109	65	87	Repeat	Note=LRR 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17567741;Dbxref=PMID:17567741
ANP32A	P39687	68	109	89	110	Repeat	Note=LRR 4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17567741;Dbxref=PMID:17567741
ANP32A	P39687	68	109	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS
ANP32A	P39687	68	109	81	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS
ANP32A	P39687	68	109	92	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS
ANP32A	P39687	68	109	103	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS
ANP32A	P39687	68	109	107	111	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS
ANKRD2	Q9GZV1	245	278	1	360	Chain	ID=PRO_0000066897;Note=Ankyrin repeat domain-containing protein 2
ANKRD2	Q9GZV1	245	278	246	275	Repeat	Note=ANK 4
ANKRD2	Q9GZV1	245	278	246	278	Alternative sequence	ID=VSP_000269;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKRD12	Q6UB98	78	101	1	2062	Chain	ID=PRO_0000066908;Note=Ankyrin repeat domain-containing protein 12
ANKRD12	Q6UB98	1888	1921	1	2062	Chain	ID=PRO_0000066908;Note=Ankyrin repeat domain-containing protein 12
ANKRD12	Q6UB98	1921	1969	1	2062	Chain	ID=PRO_0000066908;Note=Ankyrin repeat domain-containing protein 12
ANKRD12	Q6UB98	1969	2001	1	2062	Chain	ID=PRO_0000066908;Note=Ankyrin repeat domain-containing protein 12
ANKRD12	Q6UB98	78	101	79	101	Alternative sequence	ID=VSP_010901;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15184363,ECO:0000303|PubMed:17974005;Dbxref=PMID:15184363,PMID:17974005
ANKRD24	Q8TF21	12	41	1	1146	Chain	ID=PRO_0000328836;Note=Ankyrin repeat domain-containing protein 24
ANKRD24	Q8TF21	1001	1057	1	1146	Chain	ID=PRO_0000328836;Note=Ankyrin repeat domain-containing protein 24
ANKRD24	Q8TF21	12	41	1	1146	Chain	ID=PRO_0000328836;Note=Ankyrin repeat domain-containing protein 24
ANKRD24	Q8TF21	1001	1057	1	1146	Chain	ID=PRO_0000328836;Note=Ankyrin repeat domain-containing protein 24
ANKRD24	Q8TF21	1001	1057	714	1110	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD24	Q8TF21	1001	1057	714	1110	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD24	Q8TF21	12	41	1	41	Alternative sequence	ID=VSP_032811;Note=In isoform 2. MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQ->MQPAACAGEGAGPPAPRPPHPPGDKVRRGRGGAPSLSPQPPAPYLGLPIPSRGGGGWRGGQGGGGGTREGGTGRAGGAGSSGSAQPRPPAAPRGPSRPSGRRLLLEPRAPPAPRAPDAMKQLCLCAAASFA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11853319;Dbxref=PMID:11853319
ANKRD24	Q8TF21	12	41	1	41	Alternative sequence	ID=VSP_032811;Note=In isoform 2. MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQ->MQPAACAGEGAGPPAPRPPHPPGDKVRRGRGGAPSLSPQPPAPYLGLPIPSRGGGGWRGGQGGGGGTREGGTGRAGGAGSSGSAQPRPPAAPRGPSRPSGRRLLLEPRAPPAPRAPDAMKQLCLCAAASFA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11853319;Dbxref=PMID:11853319
ANKRD26	Q9UPS8	1405	1502	1	1710	Chain	ID=PRO_0000240843;Note=Ankyrin repeat domain-containing protein 26
ANKRD26	Q9UPS8	1218	1269	1	1710	Chain	ID=PRO_0000240843;Note=Ankyrin repeat domain-containing protein 26
ANKRD26	Q9UPS8	899	1218	1	1710	Chain	ID=PRO_0000240843;Note=Ankyrin repeat domain-containing protein 26
ANKRD26	Q9UPS8	454	487	1	1710	Chain	ID=PRO_0000240843;Note=Ankyrin repeat domain-containing protein 26
ANKRD26	Q9UPS8	1405	1502	905	1472	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD26	Q9UPS8	1218	1269	905	1472	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD26	Q9UPS8	899	1218	905	1472	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD26	Q9UPS8	454	487	444	545	Alternative sequence	ID=VSP_019435;Note=In isoform 2. KEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQ->MNHMFHIKRHSISAGTDAYKKTKPIQNLFQKPLYDHCSANNYKSMEPELENVRSSPPRGDRTSKVSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD26	Q9UPS8	1218	1269	1220	1220	Natural variant	ID=VAR_055514;Note=V->L;Dbxref=dbSNP:rs12572862
MAOB	P27338	93	128	2	520	Chain	ID=PRO_0000099859;Note=Amine oxidase [flavin-containing] B
MAOB	P27338	47	93	2	520	Chain	ID=PRO_0000099859;Note=Amine oxidase [flavin-containing] B
MAOB	P27338	93	128	2	489	Topological domain	Note=Cytoplasmic
MAOB	P27338	47	93	2	489	Topological domain	Note=Cytoplasmic
MAOB	P27338	47	93	36	52	Compositional bias	Note=Arg/Lys-rich (basic)
MAOB	P27338	47	93	52	52	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BW75
MAOB	P27338	47	93	45	48	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XFN
MAOB	P27338	47	93	49	51	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	47	93	54	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	47	93	66	74	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	47	93	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	47	93	85	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	93	128	95	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	93	128	101	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
MAOB	P27338	93	128	109	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E
AOX1	Q06278	166	196	1	1338	Chain	ID=PRO_0000166104;Note=Aldehyde oxidase
AOX1	Q06278	856	885	1	1338	Chain	ID=PRO_0000166104;Note=Aldehyde oxidase
AOX1	Q06278	1025	1057	1	1338	Chain	ID=PRO_0000166104;Note=Aldehyde oxidase
AOX1	Q06278	1100	1125	1	1338	Chain	ID=PRO_0000166104;Note=Aldehyde oxidase
AOX1	Q06278	1181	1203	1	1338	Chain	ID=PRO_0000166104;Note=Aldehyde oxidase
AOX1	Q06278	1266	1322	1	1338	Chain	ID=PRO_0000166104;Note=Aldehyde oxidase
AOX1	Q06278	1266	1322	1270	1270	Active site	Note=Proton acceptor%3B for azaheterocycle hydroxylase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O54754
AOX1	Q06278	1025	1057	1047	1047	Binding site	Note=Molybdopterin%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:4UHW,ECO:0000244|PDB:4UHX,ECO:0000244|PDB:5EPG,ECO:0000269|PubMed:26322824,ECO:0000269|PubMed:26842593;Dbxref=PMID:26322824,PMID:26842593
AOX1	Q06278	1181	1203	1203	1203	Binding site	Note=Molybdopterin;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:4UHW,ECO:0000244|PDB:4UHX,ECO:0000244|PDB:5EPG,ECO:0000269|PubMed:26322824,ECO:0000269|PubMed:26842593;Dbxref=PMID:26322824,PMID:26842593
AOX1	Q06278	1266	1322	1268	1268	Binding site	Note=Molybdopterin%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4UHX,ECO:0000269|PubMed:26322824;Dbxref=PMID:26322824
AOX1	Q06278	1266	1322	1271	1271	Natural variant	ID=VAR_070258;Note=No effect on dimerization%3B no effect on oxidase activity. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22279051,ECO:0000269|PubMed:26842593;Dbxref=dbSNP:rs141786030,PMID:22279051,PMID:26842593
AOX1	Q06278	1266	1322	1297	1297	Natural variant	ID=VAR_047518;Note=Increases homodimerization and turnover number with phenanthridine as substrate%3B nearly no effect on kinetic parameters with benzaldehyde%2C phtalazine and chloroquinazolinone as substrate. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22279051;Dbxref=dbSNP:rs3731722,PMID:22279051
AOX1	Q06278	1266	1322	1269	1269	Mutagenesis	Note=No effect on dimerization. Loss of oxidase activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26842593;Dbxref=PMID:26842593
AOX1	Q06278	856	885	851	859	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	856	885	865	878	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	856	885	884	893	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1025	1057	1026	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1025	1057	1038	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1025	1057	1047	1049	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1025	1057	1051	1062	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1100	1125	1091	1115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1100	1125	1122	1131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1181	1203	1180	1190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1181	1203	1197	1215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1266	1322	1271	1276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1266	1322	1277	1293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1266	1322	1308	1314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AOX1	Q06278	1266	1322	1318	1322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UHW
AP5Z1	O43299	485	531	1	807	Chain	ID=PRO_0000261357;Note=AP-5 complex subunit zeta-1
AP4B1	Q9Y6B7	503	597	1	739	Chain	ID=PRO_0000193750;Note=AP-4 complex subunit beta-1
AP4B1	Q9Y6B7	38	112	1	739	Chain	ID=PRO_0000193750;Note=AP-4 complex subunit beta-1
AP4B1	Q9Y6B7	503	597	1	739	Chain	ID=PRO_0000193750;Note=AP-4 complex subunit beta-1
AP4B1	Q9Y6B7	38	112	1	739	Chain	ID=PRO_0000193750;Note=AP-4 complex subunit beta-1
AP4B1	Q9Y6B7	503	597	534	600	Region	Note=Hinge;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26542808;Dbxref=PMID:26542808
AP4B1	Q9Y6B7	503	597	534	600	Region	Note=Hinge;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26542808;Dbxref=PMID:26542808
AP4B1	Q9Y6B7	503	597	396	739	Alternative sequence	ID=VSP_055789;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AP4B1	Q9Y6B7	503	597	396	739	Alternative sequence	ID=VSP_055789;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALG14	Q96F25	96	140	1	216	Chain	ID=PRO_0000265116;Note=UDP-N-acetylglucosamine transferase subunit ALG14 homolog
ALG14	Q96F25	96	140	25	216	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P38242
ALKBH3	Q96Q83	153	223	1	286	Chain	ID=PRO_0000239278;Note=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
ALKBH3	Q96Q83	153	223	172	278	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
ALKBH3	Q96Q83	153	223	179	181	Region	Note=Alpha-ketoglutarate binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2IUW,ECO:0000269|PubMed:16858410;Dbxref=PMID:16858410
ALKBH3	Q96Q83	153	223	191	191	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:2IUW,ECO:0000255|PROSITE-ProRule:PRU00805,ECO:0000269|PubMed:16858410;Dbxref=PMID:16858410
ALKBH3	Q96Q83	153	223	193	193	Metal binding	Note=Iron%3B catalytic;Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269;evidence=ECO:0000244|PDB:2IUW,ECO:0000255|PROSITE-ProRule:PRU00805,ECO:0000269|PubMed:16858410;Dbxref=PMID:16858410
ALKBH3	Q96Q83	153	223	194	194	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6NS38
ALKBH3	Q96Q83	153	223	177	177	Modified residue	Note=(4R)-5-hydroxyleucine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16858410;Dbxref=PMID:16858410
ALKBH3	Q96Q83	153	223	177	177	Modified residue	Note=(4R)-5-oxoleucine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16858410;Dbxref=PMID:16858410
ALKBH3	Q96Q83	153	223	125	172	Alternative sequence	ID=VSP_019126;Note=In isoform 2. ITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHT->SILQLTFKKSAPVSGTATAPQSCWYERPSPPHIPGPAILTRTRLWAP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALKBH3	Q96Q83	153	223	173	286	Alternative sequence	ID=VSP_019127;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALKBH3	Q96Q83	153	223	164	164	Natural variant	ID=VAR_026632;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs2271815
ALKBH3	Q96Q83	153	223	177	177	Mutagenesis	Note=Loss of activity against 1-methyladenine. L->A%2CN
ALKBH3	Q96Q83	153	223	177	177	Mutagenesis	Note=Loss of activity. L->E%2CQ
ALKBH3	Q96Q83	153	223	177	177	Mutagenesis	Note=Decreases activity against 1-methyladenine. L->I
ALKBH3	Q96Q83	153	223	177	177	Mutagenesis	Note=No effect. L->M
ALKBH3	Q96Q83	153	223	179	179	Mutagenesis	Note=Decreases activity by about 60%25. N->A
ALKBH3	Q96Q83	153	223	181	181	Mutagenesis	Note=Strong decrease of activity. Y->A
ALKBH3	Q96Q83	153	223	189	189	Mutagenesis	Note=Strongly increases activity towards dsDNA%2C possibly by facilitating access to the active site. D->A
ALKBH3	Q96Q83	153	223	191	191	Mutagenesis	Note=Loss of activity. H->A
ALKBH3	Q96Q83	153	223	193	193	Mutagenesis	Note=Loss of activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16174769,ECO:0000269|PubMed:26863196;Dbxref=PMID:16174769,PMID:26863196
ALKBH3	Q96Q83	153	223	151	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH3	Q96Q83	153	223	156	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH3	Q96Q83	153	223	175	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH3	Q96Q83	153	223	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH3	Q96Q83	153	223	196	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH3	Q96Q83	153	223	204	211	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH3	Q96Q83	153	223	213	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IUW
ALKBH6	Q3KRA9	18	41	1	238	Chain	ID=PRO_0000323716;Note=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
AMPD1	P23109	332	397	1	780	Chain	ID=PRO_0000194403;Note=AMP deaminase 1
AMPD1	P23109	332	397	336	336	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
AMPD1	P23109	332	397	338	338	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000250;evidence=ECO:0000250
AMPD1	P23109	332	397	338	338	Binding site	Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
ANKLE2	Q86XL3	410	451	1	938	Chain	ID=PRO_0000280242;Note=Ankyrin repeat and LEM domain-containing protein 2
ANKLE2	Q86XL3	213	282	1	938	Chain	ID=PRO_0000280242;Note=Ankyrin repeat and LEM domain-containing protein 2
ANKLE2	Q86XL3	410	451	33	938	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKLE2	Q86XL3	213	282	33	938	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKLE2	Q86XL3	410	451	411	440	Repeat	Note=ANK
ANKLE2	Q86XL3	213	282	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ANKLE2	Q86XL3	213	282	268	268	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ANKLE2	Q86XL3	410	451	1	645	Alternative sequence	ID=VSP_044173;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKLE2	Q86XL3	213	282	1	645	Alternative sequence	ID=VSP_044173;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKLE2	Q86XL3	213	282	266	266	Sequence conflict	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANKRD35	Q8N283	261	929	1	1001	Chain	ID=PRO_0000243910;Note=Ankyrin repeat domain-containing protein 35
ANKRD35	Q8N283	261	929	295	344	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD35	Q8N283	261	929	610	696	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD35	Q8N283	261	929	733	810	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD35	Q8N283	261	929	851	968	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD35	Q8N283	261	929	527	533	Compositional bias	Note=Poly-Ala
ANKRD35	Q8N283	261	929	138	1001	Alternative sequence	ID=VSP_056917;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD35	Q8N283	261	929	428	428	Natural variant	ID=VAR_026870;Note=P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6670984,PMID:14702039,PMID:15489334
ANKRD35	Q8N283	261	929	592	592	Natural variant	ID=VAR_061017;Note=R->Q;Dbxref=dbSNP:rs41315701
ANKRD35	Q8N283	261	929	820	820	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANO3	Q9BYT9	231	245	1	981	Chain	ID=PRO_0000072565;Note=Anoctamin-3
ANO3	Q9BYT9	231	245	1	403	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD42	Q8N9B4	234	276	1	389	Chain	ID=PRO_0000244371;Note=Ankyrin repeat domain-containing protein 42
ANKRD42	Q8N9B4	234	276	235	265	Repeat	Note=ANK 7
ANKRD42	Q8N9B4	234	276	269	298	Repeat	Note=ANK 8
ANKRD42	Q8N9B4	234	276	171	389	Alternative sequence	ID=VSP_019561;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANO7	Q6IWH7	461	507	1	933	Chain	ID=PRO_0000289326;Note=Anoctamin-7
ANO7	Q6IWH7	858	898	1	933	Chain	ID=PRO_0000289326;Note=Anoctamin-7
ANO7	Q6IWH7	898	915	1	933	Chain	ID=PRO_0000289326;Note=Anoctamin-7
ANO7	Q6IWH7	461	507	442	499	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO7	Q6IWH7	461	507	500	520	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO7	Q6IWH7	858	898	844	864	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO7	Q6IWH7	858	898	865	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO7	Q6IWH7	898	915	865	933	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO7	Q6IWH7	461	507	181	933	Alternative sequence	ID=VSP_026006;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14981236;Dbxref=PMID:14981236
ANO7	Q6IWH7	858	898	181	933	Alternative sequence	ID=VSP_026006;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14981236;Dbxref=PMID:14981236
ANO7	Q6IWH7	898	915	181	933	Alternative sequence	ID=VSP_026006;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14981236;Dbxref=PMID:14981236
ANO7	Q6IWH7	858	898	859	859	Alternative sequence	ID=VSP_026007;Note=In isoform 3. H->VAEAPAGSPIHGMRPRPCALPNSSTW;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANO7	Q6IWH7	858	898	860	933	Alternative sequence	ID=VSP_026008;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANO7	Q6IWH7	898	915	860	933	Alternative sequence	ID=VSP_026008;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANO7	Q6IWH7	898	915	912	912	Natural variant	ID=VAR_065166;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14981236;Dbxref=dbSNP:rs7590653,PMID:14981236
ANKFN1	Q8N957	522	594	1	763	Chain	ID=PRO_0000247138;Note=Ankyrin repeat and fibronectin type-III domain-containing protein 1
ANKRD53	Q8N9V6	206	260	1	530	Chain	ID=PRO_0000274490;Note=Ankyrin repeat domain-containing protein 53
ANKRD53	Q8N9V6	206	260	173	206	Repeat	Note=ANK 2
ANKRD53	Q8N9V6	206	260	210	239	Repeat	Note=ANK 3
ANKRD53	Q8N9V6	206	260	243	243	Natural variant	ID=VAR_054427;Note=M->T;Dbxref=dbSNP:rs36123544
ANKRD22	Q5VYY1	133	166	1	191	Chain	ID=PRO_0000240838;Note=Ankyrin repeat domain-containing protein 22
ANKRD22	Q5VYY1	107	133	1	191	Chain	ID=PRO_0000240838;Note=Ankyrin repeat domain-containing protein 22
ANKRD22	Q5VYY1	71	107	1	191	Chain	ID=PRO_0000240838;Note=Ankyrin repeat domain-containing protein 22
ANKRD22	Q5VYY1	71	107	72	100	Repeat	Note=ANK 2
ANKRD22	Q5VYY1	107	133	101	130	Repeat	Note=ANK 3
ANKRD22	Q5VYY1	71	107	101	130	Repeat	Note=ANK 3
ANKRD22	Q5VYY1	133	166	134	163	Repeat	Note=ANK 4
ANKRD22	Q5VYY1	71	107	73	73	Natural variant	ID=VAR_027628;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17113412,PMID:15489334
ANKRD22	Q5VYY1	71	107	79	79	Natural variant	ID=VAR_027629;Note=Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17851907,PMID:15489334
ANKRD22	Q5VYY1	133	166	148	148	Natural variant	ID=VAR_027630;Note=Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2304804,PMID:15489334
APBB3	O95704	344	408	1	486	Chain	ID=PRO_0000076054;Note=Amyloid-beta A4 precursor protein-binding family B member 3
APBB3	O95704	344	408	285	440	Domain	Note=PID 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBB3	O95704	344	408	215	486	Alternative sequence	ID=VSP_047813;Note=In isoform I-214. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12153398;Dbxref=PMID:12153398
APBB3	O95704	344	408	246	486	Alternative sequence	ID=VSP_047814;Note=In isoform I-245. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12153398;Dbxref=PMID:12153398
APBB3	O95704	344	408	354	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
APBB3	O95704	344	408	359	361	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
APBB3	O95704	344	408	362	367	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
APBB3	O95704	344	408	373	379	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
APBB3	O95704	344	408	381	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
APBB3	O95704	344	408	385	391	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
APBB3	O95704	344	408	397	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYQ
ANAPC4	Q9UJX5	157	171	1	808	Chain	ID=PRO_0000064595;Note=Anaphase-promoting complex subunit 4
ANAPC4	Q9UJX5	263	292	1	808	Chain	ID=PRO_0000064595;Note=Anaphase-promoting complex subunit 4
ANAPC4	Q9UJX5	634	691	1	808	Chain	ID=PRO_0000064595;Note=Anaphase-promoting complex subunit 4
ANAPC4	Q9UJX5	634	691	552	808	Alternative sequence	ID=VSP_008465;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ANAPC4	Q9UJX5	263	292	286	286	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANAPC4	Q9UJX5	157	171	155	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	157	171	162	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	263	292	245	284	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	634	691	636	645	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	634	691	648	657	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	634	691	659	661	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	634	691	664	670	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	634	691	671	673	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
ANAPC4	Q9UJX5	634	691	679	682	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5BPW
APC	P25054	215	243	2	2843	Chain	ID=PRO_0000064627;Note=Adenomatous polyposis coli protein
APC	P25054	215	243	2	2843	Chain	ID=PRO_0000064627;Note=Adenomatous polyposis coli protein
APC	P25054	215	243	127	248	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
APC	P25054	215	243	127	248	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
APC	P25054	215	243	1	730	Compositional bias	Note=Leu-rich
APC	P25054	215	243	1	730	Compositional bias	Note=Leu-rich
APC	P25054	215	243	217	244	Alternative sequence	ID=VSP_059028;Note=In isoform 1B. Missing
APC	P25054	215	243	217	244	Alternative sequence	ID=VSP_059028;Note=In isoform 1B. Missing
APC	P25054	215	243	208	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I
APC	P25054	215	243	208	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I
ACSS3	Q9H6R3	215	260	30	686	Chain	ID=PRO_0000320624;Note=Acyl-CoA synthetase short-chain family member 3%2C mitochondrial
ACSS3	Q9H6R3	215	260	227	230	Region	Note=Coenzyme A binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
ACSS3	Q9H6R3	215	260	1	318	Alternative sequence	ID=VSP_031692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALG6	Q9Y672	56	85	1	507	Chain	ID=PRO_0000174156;Note=Dolichyl pyrophosphate Man9GlcNAc2 alpha-1%2C3-glucosyltransferase
ALG6	Q9Y672	355	377	1	507	Chain	ID=PRO_0000174156;Note=Dolichyl pyrophosphate Man9GlcNAc2 alpha-1%2C3-glucosyltransferase
ALG6	Q9Y672	56	85	1	507	Chain	ID=PRO_0000174156;Note=Dolichyl pyrophosphate Man9GlcNAc2 alpha-1%2C3-glucosyltransferase
ALG6	Q9Y672	353	375	1	507	Chain	ID=PRO_0000174156;Note=Dolichyl pyrophosphate Man9GlcNAc2 alpha-1%2C3-glucosyltransferase
ALG6	Q9Y672	355	377	362	382	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG6	Q9Y672	353	375	362	382	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG6	Q9Y672	355	377	374	374	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALG6	Q9Y672	353	375	374	374	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
AGO2	Q9UKV8	723	757	1	859	Chain	ID=PRO_0000194057;Note=Protein argonaute-2
AGO2	Q9UKV8	678	723	1	859	Chain	ID=PRO_0000194057;Note=Protein argonaute-2
AGO2	Q9UKV8	723	757	517	818	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03031
AGO2	Q9UKV8	678	723	517	818	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03031
AGO2	Q9UKV8	678	723	709	710	Region	Note=Interaction with guide RNA
AGO2	Q9UKV8	723	757	753	761	Region	Note=Interaction with guide RNA
AGO2	Q9UKV8	678	723	700	700	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03031,ECO:0000269|PubMed:18690212;Dbxref=PMID:18690212
AGO2	Q9UKV8	723	757	724	757	Alternative sequence	ID=VSP_037001;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGO2	Q9UKV8	678	723	682	682	Mutagenesis	Note=No effect. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15284456;Dbxref=PMID:15284456
AGO2	Q9UKV8	678	723	683	683	Mutagenesis	Note=No effect on RNA cleavage. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800637;Dbxref=PMID:15800637
AGO2	Q9UKV8	678	723	700	700	Mutagenesis	Note=Reduced protein stability. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18690212;Dbxref=PMID:18690212
AGO2	Q9UKV8	678	723	704	704	Mutagenesis	Note=No effect. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15284456;Dbxref=PMID:15284456
AGO2	Q9UKV8	723	757	744	744	Mutagenesis	Note=No effect. T->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15284456;Dbxref=PMID:15284456
AGO2	Q9UKV8	678	723	676	694	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	678	723	701	709	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	678	723	710	712	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W5Q
AGO2	Q9UKV8	678	723	715	719	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	678	723	720	722	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	725	728	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	734	736	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	738	741	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	743	745	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	747	751	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	757	759	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CBD
ANKIB1	Q9P2G1	162	223	2	1089	Chain	ID=PRO_0000066892;Note=Ankyrin repeat and IBR domain-containing protein 1
ANKIB1	Q9P2G1	539	584	2	1089	Chain	ID=PRO_0000066892;Note=Ankyrin repeat and IBR domain-containing protein 1
ANKIB1	Q9P2G1	584	613	2	1089	Chain	ID=PRO_0000066892;Note=Ankyrin repeat and IBR domain-containing protein 1
ANKIB1	Q9P2G1	162	223	144	173	Repeat	Note=ANK 2
ANKIB1	Q9P2G1	539	584	519	548	Zinc finger	Note=RING-type 2%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
ANKIB1	Q9P2G1	539	584	575	640	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKIB1	Q9P2G1	584	613	575	640	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AKIRIN2	Q53H80	176	200	1	203	Chain	ID=PRO_0000089555;Note=Akirin-2
AKIRIN2	Q53H80	126	176	1	203	Chain	ID=PRO_0000089555;Note=Akirin-2
AKIRIN2	Q53H80	126	176	171	171	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKTIP	Q9H8T0	201	236	1	292	Chain	ID=PRO_0000082609;Note=AKT-interacting protein
AKTIP	Q9H8T0	201	236	1	292	Chain	ID=PRO_0000082609;Note=AKT-interacting protein
AKTIP	Q9H8T0	201	236	212	212	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKTIP	Q9H8T0	201	236	212	212	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKAP7	Q9P0M2	16	39	1	348	Chain	ID=PRO_0000064523;Note=A-kinase anchor protein 7 isoform gamma
AKAP7	Q9P0M2	16	39	26	26	Natural variant	ID=VAR_024246;Note=E->K;Dbxref=dbSNP:rs7771473
ALDH7A1	P49419	400	439	27	539	Chain	ID=PRO_0000056490;Note=Alpha-aminoadipic semialdehyde dehydrogenase
ALDH7A1	P49419	104	131	27	539	Chain	ID=PRO_0000056490;Note=Alpha-aminoadipic semialdehyde dehydrogenase
ALDH7A1	P49419	400	439	337	400	Alternative sequence	ID=VSP_045905;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALDH7A1	P49419	400	439	412	412	Natural variant	ID=VAR_028202;Note=T->A;Dbxref=dbSNP:rs2306618
ALDH7A1	P49419	400	439	427	427	Natural variant	ID=VAR_031719;Note=In PDE. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16491085,ECO:0000269|PubMed:17068770;Dbxref=dbSNP:rs121912707,PMID:16491085,PMID:17068770
ALDH7A1	P49419	400	439	439	439	Natural variant	ID=VAR_028203;Note=K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs12514417,PMID:15489334
ALDH7A1	P49419	104	131	107	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J6L
ALDH7A1	P49419	104	131	125	135	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J6L
ALDH7A1	P49419	400	439	403	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J6L
ALDH7A1	P49419	400	439	412	416	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J6L
ALDH7A1	P49419	400	439	422	425	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J6L
ALDH7A1	P49419	400	439	429	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J6L
AGMO	Q6ZNB7	225	247	1	445	Chain	ID=PRO_0000299300;Note=Alkylglycerol monooxygenase
AGMO	Q6ZNB7	225	247	221	225	Motif	Note=Histidine box-3
AGMO	Q6ZNB7	225	247	225	225	Mutagenesis	Note=Loss of function%3B when associated with A-132%3B A-136%3B A-145%3B A-148%3B A-149%3B A-221 and A-224. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20643956;Dbxref=PMID:20643956
ANKRD36C	Q5JPF3	1665	1716	1	1778	Chain	ID=PRO_0000334545;Note=Ankyrin repeat domain-containing protein 36C
ANKRD36C	Q5JPF3	1665	1716	1544	1768	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD36C	Q5JPF3	1665	1716	1186	1778	Alternative sequence	ID=VSP_039674;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZFYVE19	Q96K21	134	150	1	471	Chain	ID=PRO_0000098718;Note=Abscission/NoCut checkpoint regulator
ZFYVE19	Q96K21	275	343	1	471	Chain	ID=PRO_0000098718;Note=Abscission/NoCut checkpoint regulator
ZFYVE19	Q96K21	370	403	1	471	Chain	ID=PRO_0000098718;Note=Abscission/NoCut checkpoint regulator
ZFYVE19	Q96K21	275	343	311	375	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZFYVE19	Q96K21	370	403	311	375	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZFYVE19	Q96K21	275	343	326	339	Motif	Note=MIM1-B
ZFYVE19	Q96K21	134	150	145	146	Site	Note=Breakpoint for translocation to form KMT2A/MLL1-ZFYVE19
ZFYVE19	Q96K21	134	150	144	144	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZFYVE19	Q96K21	275	343	293	293	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZFYVE19	Q96K21	134	150	1	175	Alternative sequence	ID=VSP_046008;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZFYVE19	Q96K21	275	343	276	343	Alternative sequence	ID=VSP_013792;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ZFYVE19	Q96K21	370	403	376	376	Natural variant	ID=VAR_060474;Note=S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs690347,PMID:14702039,PMID:15489334
ZFYVE19	Q96K21	370	403	398	398	Natural variant	ID=VAR_060475;Note=R->C;Dbxref=dbSNP:rs72735636
ANTXR2	P58335	162	185	34	489	Chain	ID=PRO_0000002694;Note=Anthrax toxin receptor 2
ANTXR2	P58335	162	185	34	318	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANTXR2	P58335	162	185	44	213	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
ANTXR2	P58335	162	185	39	218	Disulfide bond	.
ANTXR2	P58335	162	185	155	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SHU
ANTXR2	P58335	162	185	172	177	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SHU
ANTXR2	P58335	162	185	183	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SHU
ANKS3	Q6ZW76	603	631	1	656	Chain	ID=PRO_0000230777;Note=Ankyrin repeat and SAM domain-containing protein 3
ANKS3	Q6ZW76	236	289	1	656	Chain	ID=PRO_0000230777;Note=Ankyrin repeat and SAM domain-containing protein 3
APBA2	Q99767	405	417	1	749	Chain	ID=PRO_0000064616;Note=Amyloid-beta A4 precursor protein-binding family A member 2
APBA2	Q99767	679	726	1	749	Chain	ID=PRO_0000064616;Note=Amyloid-beta A4 precursor protein-binding family A member 2
APBA2	Q99767	405	417	1	749	Chain	ID=PRO_0000064616;Note=Amyloid-beta A4 precursor protein-binding family A member 2
APBA2	Q99767	679	726	1	749	Chain	ID=PRO_0000064616;Note=Amyloid-beta A4 precursor protein-binding family A member 2
APBA2	Q99767	405	417	1	749	Chain	ID=PRO_0000064616;Note=Amyloid-beta A4 precursor protein-binding family A member 2
APBA2	Q99767	679	726	1	749	Chain	ID=PRO_0000064616;Note=Amyloid-beta A4 precursor protein-binding family A member 2
APBA2	Q99767	405	417	368	555	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBA2	Q99767	405	417	368	555	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBA2	Q99767	405	417	368	555	Domain	Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBA2	Q99767	679	726	659	734	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
APBA2	Q99767	679	726	659	734	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
APBA2	Q99767	679	726	659	734	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
APBA2	Q99767	405	417	406	417	Alternative sequence	ID=VSP_045692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBA2	Q99767	405	417	406	417	Alternative sequence	ID=VSP_045692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBA2	Q99767	405	417	406	417	Alternative sequence	ID=VSP_045692;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANAPC1	Q9H1A4	1734	1763	1	1944	Chain	ID=PRO_0000215871;Note=Anaphase-promoting complex subunit 1
ANAPC1	Q9H1A4	1488	1506	1	1944	Chain	ID=PRO_0000215871;Note=Anaphase-promoting complex subunit 1
ANAPC1	Q9H1A4	1407	1432	1	1944	Chain	ID=PRO_0000215871;Note=Anaphase-promoting complex subunit 1
ANAPC1	Q9H1A4	1488	1506	1467	1501	Repeat	Note=PC 3
ANAPC1	Q9H1A4	1407	1432	1401	1414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1407	1432	1416	1418	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1407	1432	1423	1429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1407	1432	1432	1436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1488	1506	1482	1500	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1488	1506	1504	1507	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1734	1763	1738	1741	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC1	Q9H1A4	1734	1763	1745	1753	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
APC2	O95996	213	239	1	2303	Chain	ID=PRO_0000313686;Note=Adenomatous polyposis coli protein 2
APC2	O95996	213	239	1	2303	Chain	ID=PRO_0000313686;Note=Adenomatous polyposis coli protein 2
APC2	O95996	213	239	168	441	Alternative sequence	ID=VSP_030106;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
APC2	O95996	213	239	168	441	Alternative sequence	ID=VSP_030106;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
AMOTL1	Q8IY63	16	66	1	956	Chain	ID=PRO_0000190670;Note=Angiomotin-like protein 1
AMOTL1	Q8IY63	829	921	1	956	Chain	ID=PRO_0000190670;Note=Angiomotin-like protein 1
AMOTL1	Q8IY63	829	921	900	900	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
AMOTL1	Q8IY63	829	921	902	902	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
AMOTL1	Q8IY63	829	921	906	906	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
AMOTL1	Q8IY63	16	66	17	66	Alternative sequence	ID=VSP_015710;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AMOTL1	Q8IY63	829	921	847	847	Natural variant	ID=VAR_033498;Note=P->L;Dbxref=dbSNP:rs11020968
AMOTL2	Q9Y2J4	701	760	1	779	Chain	ID=PRO_0000190672;Note=Angiomotin-like protein 2
AMOTL2	Q9Y2J4	395	426	1	779	Chain	ID=PRO_0000190672;Note=Angiomotin-like protein 2
AMOTL2	Q9Y2J4	395	426	308	581	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AMOTL2	Q9Y2J4	701	760	759	759	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
AMOTL2	Q9Y2J4	701	760	701	701	Alternative sequence	ID=VSP_015711;Note=In isoform 2. T->TA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10231032,ECO:0000303|PubMed:14702039;Dbxref=PMID:10231032,PMID:14702039
AMOTL2	Q9Y2J4	395	426	415	415	Natural variant	ID=VAR_055499;Note=G->S;Dbxref=dbSNP:rs2241559
AMOTL2	Q9Y2J4	701	760	731	731	Natural variant	ID=VAR_023535;Note=E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10231032,ECO:0000269|PubMed:12406577,ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1353776,PMID:10231032,PMID:12406577,PMID:14702039
AMPH	P49418	424	466	1	695	Chain	ID=PRO_0000192947;Note=Amphiphysin
AMPH	P49418	424	466	425	466	Alternative sequence	ID=VSP_000245;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9513187;Dbxref=PMID:9513187
ANKRD13B	Q86YJ7	140	188	1	626	Chain	ID=PRO_0000240643;Note=Ankyrin repeat domain-containing protein 13B
AMTN	Q6UX39	18	46	17	209	Chain	ID=PRO_0000022613;Note=Amelotin
AMTN	Q6UX39	18	46	19	19	Alternative sequence	ID=VSP_023919;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AMTN	Q6UX39	18	46	45	45	Natural variant	ID=VAR_050661;Note=N->S;Dbxref=dbSNP:rs7660807
ANO5	Q75V66	46	60	1	913	Chain	ID=PRO_0000191755;Note=Anoctamin-5
ANO5	Q75V66	216	254	1	913	Chain	ID=PRO_0000191755;Note=Anoctamin-5
ANO5	Q75V66	46	60	1	299	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO5	Q75V66	216	254	1	299	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ANO5	Q75V66	46	60	52	52	Natural variant	ID=VAR_080271;Note=In LGMD2L%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25891276;Dbxref=dbSNP:rs143777403,PMID:25891276
ANO5	Q75V66	46	60	54	54	Natural variant	ID=VAR_080272;Note=In LGMD2L%3B unknown pathological significance. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25891276;Dbxref=dbSNP:rs886043577,PMID:25891276
ANO5	Q75V66	46	60	58	58	Natural variant	ID=VAR_068247;Note=In LGMD2L%3B unknown pathological significance. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22499103,ECO:0000269|PubMed:25864073,ECO:0000269|PubMed:25891276;Dbxref=dbSNP:rs201725369,PMID:22499103,PMID:25864073,PMID:25891276
ANO5	Q75V66	216	254	231	231	Natural variant	ID=VAR_063582;Note=In LGMD2L%3B unknown pathological significance. G->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20096397,ECO:0000269|PubMed:25891276;Dbxref=dbSNP:rs137854523,PMID:20096397,PMID:25891276
ANKAR	Q7Z5J8	706	741	1	1434	Chain	ID=PRO_0000286806;Note=Ankyrin and armadillo repeat-containing protein
ANKAR	Q7Z5J8	1141	1194	1	1434	Chain	ID=PRO_0000286806;Note=Ankyrin and armadillo repeat-containing protein
ANKAR	Q7Z5J8	706	741	1	1434	Chain	ID=PRO_0000286806;Note=Ankyrin and armadillo repeat-containing protein
ANKAR	Q7Z5J8	1141	1194	1	1434	Chain	ID=PRO_0000286806;Note=Ankyrin and armadillo repeat-containing protein
ANKAR	Q7Z5J8	706	741	732	771	Repeat	Note=ARM 1
ANKAR	Q7Z5J8	706	741	732	771	Repeat	Note=ARM 1
ANKAR	Q7Z5J8	706	741	706	716	Alternative sequence	ID=VSP_025168;Note=In isoform 4. VEMLQCESYKR->KCYSVKAINEG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	706	741	706	716	Alternative sequence	ID=VSP_025168;Note=In isoform 4. VEMLQCESYKR->KCYSVKAINEG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	706	741	717	1434	Alternative sequence	ID=VSP_025169;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	1141	1194	717	1434	Alternative sequence	ID=VSP_025169;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	706	741	717	1434	Alternative sequence	ID=VSP_025169;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	1141	1194	717	1434	Alternative sequence	ID=VSP_025169;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	1141	1194	1027	1434	Alternative sequence	ID=VSP_025172;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	1141	1194	1027	1434	Alternative sequence	ID=VSP_025172;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ANKAR	Q7Z5J8	1141	1194	1081	1434	Alternative sequence	ID=VSP_025174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKAR	Q7Z5J8	1141	1194	1081	1434	Alternative sequence	ID=VSP_025174;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANXA1	P04083	185	204	2	346	Chain	ID=PRO_0000067460;Note=Annexin A1
ANXA1	P04083	235	267	2	346	Chain	ID=PRO_0000067460;Note=Annexin A1
ANXA1	P04083	287	328	2	346	Chain	ID=PRO_0000067460;Note=Annexin A1
ANXA1	P04083	185	204	2	346	Chain	ID=PRO_0000067460;Note=Annexin A1
ANXA1	P04083	235	267	2	346	Chain	ID=PRO_0000067460;Note=Annexin A1
ANXA1	P04083	287	328	2	346	Chain	ID=PRO_0000067460;Note=Annexin A1
ANXA1	P04083	235	267	207	267	Repeat	Note=Annexin 3
ANXA1	P04083	235	267	207	267	Repeat	Note=Annexin 3
ANXA1	P04083	287	328	282	342	Repeat	Note=Annexin 4
ANXA1	P04083	287	328	282	342	Repeat	Note=Annexin 4
ANXA1	P04083	235	267	253	253	Metal binding	Note=Calcium 6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	253	253	Metal binding	Note=Calcium 6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	255	255	Metal binding	Note=Calcium 5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	255	255	Metal binding	Note=Calcium 5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	256	256	Metal binding	Note=Calcium 6%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	256	256	Metal binding	Note=Calcium 6%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	261	261	Metal binding	Note=Calcium 6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	261	261	Metal binding	Note=Calcium 6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	288	288	Metal binding	Note=Calcium 7%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	288	288	Metal binding	Note=Calcium 7%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	290	290	Metal binding	Note=Calcium 7%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	290	290	Metal binding	Note=Calcium 7%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	328	328	Metal binding	Note=Calcium 8%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	328	328	Metal binding	Note=Calcium 8%3B via carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	239	239	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA1	P04083	235	267	239	239	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA1	P04083	287	328	312	312	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA1	P04083	287	328	312	312	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA1	P04083	287	328	324	343	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	287	328	324	343	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19619
ANXA1	P04083	235	267	257	257	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10107
ANXA1	P04083	235	267	257	257	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10107
ANXA11	P50995	445	486	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	248	286	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	57	187	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	445	486	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	248	286	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	57	187	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	445	486	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	248	286	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	57	187	1	505	Chain	ID=PRO_0000067510;Note=Annexin A11
ANXA11	P50995	248	286	209	269	Repeat	Note=Annexin 1
ANXA11	P50995	248	286	209	269	Repeat	Note=Annexin 1
ANXA11	P50995	248	286	209	269	Repeat	Note=Annexin 1
ANXA11	P50995	248	286	281	341	Repeat	Note=Annexin 2
ANXA11	P50995	248	286	281	341	Repeat	Note=Annexin 2
ANXA11	P50995	248	286	281	341	Repeat	Note=Annexin 2
ANXA11	P50995	445	486	440	500	Repeat	Note=Annexin 4
ANXA11	P50995	445	486	440	500	Repeat	Note=Annexin 4
ANXA11	P50995	445	486	440	500	Repeat	Note=Annexin 4
ANXA11	P50995	248	286	248	248	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	248	286	248	248	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	248	286	248	248	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	248	286	255	255	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	248	286	255	255	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	248	286	255	255	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	445	486	479	479	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	445	486	479	479	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	445	486	479	479	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA11	P50995	57	187	175	175	Natural variant	ID=VAR_080655;Note=In ALS23%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28469040;Dbxref=dbSNP:rs754594235,PMID:28469040
ANXA11	P50995	57	187	175	175	Natural variant	ID=VAR_080655;Note=In ALS23%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28469040;Dbxref=dbSNP:rs754594235,PMID:28469040
ANXA11	P50995	57	187	175	175	Natural variant	ID=VAR_080655;Note=In ALS23%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28469040;Dbxref=dbSNP:rs754594235,PMID:28469040
ANXA11	P50995	445	486	457	457	Natural variant	ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932
ANXA11	P50995	445	486	457	457	Natural variant	ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932
ANXA11	P50995	445	486	457	457	Natural variant	ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932
ANKMY2	Q8IV38	90	123	1	441	Chain	ID=PRO_0000247166;Note=Ankyrin repeat and MYND domain-containing protein 2
ANKMY2	Q8IV38	90	123	79	108	Repeat	Note=ANK 2
ANKRD27	Q96NW4	791	831	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	725	791	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	684	725	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	669	684	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	543	609	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	512	543	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	195	213	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	175	195	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	34	71	1	1050	Chain	ID=PRO_0000274556;Note=Ankyrin repeat domain-containing protein 27
ANKRD27	Q96NW4	512	543	495	524	Repeat	Note=ANK 3
ANKRD27	Q96NW4	543	609	528	560	Repeat	Note=ANK 4
ANKRD27	Q96NW4	512	543	528	560	Repeat	Note=ANK 4
ANKRD27	Q96NW4	543	609	564	593	Repeat	Note=ANK 5
ANKRD27	Q96NW4	543	609	597	627	Repeat	Note=ANK 6
ANKRD27	Q96NW4	684	725	668	698	Repeat	Note=ANK 7
ANKRD27	Q96NW4	669	684	668	698	Repeat	Note=ANK 7
ANKRD27	Q96NW4	725	791	743	772	Repeat	Note=ANK 8
ANKRD27	Q96NW4	791	831	776	805	Repeat	Note=ANK 9
ANKRD27	Q96NW4	725	791	776	805	Repeat	Note=ANK 9
ANKRD27	Q96NW4	791	831	809	838	Repeat	Note=ANK 10
ANKRD27	Q96NW4	195	213	1	372	Region	Note=Sufficient for GEF activity towards RAB21;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16525121;Dbxref=PMID:16525121
ANKRD27	Q96NW4	175	195	1	372	Region	Note=Sufficient for GEF activity towards RAB21;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16525121;Dbxref=PMID:16525121
ANKRD27	Q96NW4	34	71	1	372	Region	Note=Sufficient for GEF activity towards RAB21;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16525121;Dbxref=PMID:16525121
ANKRD27	Q96NW4	725	791	451	730	Region	Note=Interaction with RAB32;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UMR0
ANKRD27	Q96NW4	684	725	451	730	Region	Note=Interaction with RAB32;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UMR0
ANKRD27	Q96NW4	669	684	451	730	Region	Note=Interaction with RAB32;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UMR0
ANKRD27	Q96NW4	543	609	451	730	Region	Note=Interaction with RAB32;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UMR0
ANKRD27	Q96NW4	512	543	451	730	Region	Note=Interaction with RAB32;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UMR0
ANKRD27	Q96NW4	543	609	451	600	Region	Note=Interaction with RAB38;Ontology_term=ECO:0000250,ECO:0000269;evidence=ECO:0000250|UniProtKB:Q3UMR0,ECO:0000269|PubMed:18477474;Dbxref=PMID:18477474
ANKRD27	Q96NW4	512	543	451	600	Region	Note=Interaction with RAB38;Ontology_term=ECO:0000250,ECO:0000269;evidence=ECO:0000250|UniProtKB:Q3UMR0,ECO:0000269|PubMed:18477474;Dbxref=PMID:18477474
ANKRD27	Q96NW4	684	725	658	707	Region	Note=Required for interaction with VAMP7;Ontology_term=ECO:0000250,ECO:0000269,ECO:0000269;evidence=ECO:0000250|UniProtKB:Q3UMR0,ECO:0000269|PubMed:19745841,ECO:0000269|PubMed:23104059;Dbxref=PMID:19745841,PMID:23104059
ANKRD27	Q96NW4	669	684	658	707	Region	Note=Required for interaction with VAMP7;Ontology_term=ECO:0000250,ECO:0000269,ECO:0000269;evidence=ECO:0000250|UniProtKB:Q3UMR0,ECO:0000269|PubMed:19745841,ECO:0000269|PubMed:23104059;Dbxref=PMID:19745841,PMID:23104059
ANKRD27	Q96NW4	725	791	692	746	Region	Note=Sufficient for interaction with VPS29;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	684	725	692	746	Region	Note=Sufficient for interaction with VPS29;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	725	791	761	761	Natural variant	ID=VAR_030318;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11230166;Dbxref=dbSNP:rs2302970,PMID:11230166
ANKRD27	Q96NW4	512	543	513	513	Mutagenesis	Note=Disrupts interaction with RAB32. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	543	609	546	546	Mutagenesis	Note=Impairs interaction with RAB32. K->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	543	609	550	550	Mutagenesis	Note=Impairs interaction with RAB32. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	669	684	679	679	Mutagenesis	Note=Disrupts interaction with VAMP7. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23104059;Dbxref=PMID:23104059
ANKRD27	Q96NW4	669	684	681	681	Mutagenesis	Note=Disrupts interaction with VAMP7. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23104059;Dbxref=PMID:23104059
ANKRD27	Q96NW4	684	725	684	684	Mutagenesis	Note=Disrupts interaction with VAMP7. M->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23104059;Dbxref=PMID:23104059
ANKRD27	Q96NW4	669	684	684	684	Mutagenesis	Note=Disrupts interaction with VAMP7. M->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23104059;Dbxref=PMID:23104059
ANKRD27	Q96NW4	684	725	687	687	Mutagenesis	Note=Disrupts interaction with VAMP7. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23104059;Dbxref=PMID:23104059
ANKRD27	Q96NW4	684	725	712	712	Mutagenesis	Note=Disrupts interaction with VPS29%3B when associated with A-714. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	684	725	714	714	Mutagenesis	Note=Disrupts interaction with VPS29%3B when associated with A-712. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24856514;Dbxref=PMID:24856514
ANKRD27	Q96NW4	175	195	160	175	Sequence conflict	Note=HRTFRECERKSLRHHI->LIEHSENARERASVTT;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANKRD27	Q96NW4	512	543	509	517	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	512	543	532	538	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	543	609	542	551	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	512	543	542	551	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	543	609	552	554	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	543	609	568	574	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	543	609	578	586	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	543	609	601	604	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	543	609	608	615	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CYM
ANKRD27	Q96NW4	669	684	668	678	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	684	725	682	689	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	669	684	682	689	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	725	791	747	753	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	725	791	759	765	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	725	791	780	787	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	791	831	790	798	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	725	791	790	798	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	791	831	813	819	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	791	831	823	825	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANKRD27	Q96NW4	791	831	826	831	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4B93
ANLN	Q9NQW6	57	162	1	1124	Chain	ID=PRO_0000227965;Note=Anillin
ANLN	Q9NQW6	429	465	1	1124	Chain	ID=PRO_0000227965;Note=Anillin
ANLN	Q9NQW6	507	544	1	1124	Chain	ID=PRO_0000227965;Note=Anillin
ANLN	Q9NQW6	990	1026	1	1124	Chain	ID=PRO_0000227965;Note=Anillin
ANLN	Q9NQW6	990	1026	983	1107	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ANLN	Q9NQW6	57	162	1	230	Region	Note=Nuclear localization
ANLN	Q9NQW6	57	162	1	155	Region	Note=Interaction with CD2AP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800069;Dbxref=PMID:15800069
ANLN	Q9NQW6	429	465	231	676	Region	Note=Interaction with F-actin
ANLN	Q9NQW6	507	544	231	676	Region	Note=Interaction with F-actin
ANLN	Q9NQW6	990	1026	730	1124	Region	Note=Localization to the cleavage furrow
ANLN	Q9NQW6	57	162	72	72	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ANLN	Q9NQW6	57	162	97	97	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K298
ANLN	Q9NQW6	57	162	102	102	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ANLN	Q9NQW6	429	465	449	449	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
ANLN	Q9NQW6	507	544	518	518	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ANLN	Q9NQW6	507	544	508	544	Alternative sequence	ID=VSP_017617;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ANLN	Q9NQW6	57	162	65	65	Natural variant	ID=VAR_025661;Note=S->W;Dbxref=dbSNP:rs3735400
ANLN	Q9NQW6	429	465	431	431	Natural variant	ID=VAR_072418;Note=In FSGS8%3B results in decreased interaction with CD2AP. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24676636;Dbxref=dbSNP:rs587777741,PMID:24676636
ANLN	Q9NQW6	57	162	62	62	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANLN	Q9NQW6	990	1026	986	996	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y7B
ANLN	Q9NQW6	990	1026	999	1010	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y7B
ANLN	Q9NQW6	990	1026	1013	1019	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y7B
ANLN	Q9NQW6	990	1026	1020	1023	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y7B
ANXA3	P12429	66	104	2	323	Chain	ID=PRO_0000067477;Note=Annexin A3
ANXA3	P12429	263	304	2	323	Chain	ID=PRO_0000067477;Note=Annexin A3
ANXA3	P12429	66	104	27	87	Repeat	Note=Annexin 1
ANXA3	P12429	66	104	99	159	Repeat	Note=Annexin 2
ANXA3	P12429	263	304	258	318	Repeat	Note=Annexin 4
ANXA3	P12429	263	304	267	267	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14669
ANXA3	P12429	263	304	291	291	Natural variant	ID=VAR_013917;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs5941,PMID:10391209
ANXA3	P12429	263	304	294	294	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANXA3	P12429	66	104	68	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	66	104	78	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	66	104	91	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	263	304	263	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	263	304	269	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	263	304	280	283	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	263	304	284	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA3	P12429	263	304	299	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1AXN
ANXA4	P09525	159	178	2	319	Chain	ID=PRO_0000067482;Note=Annexin A4
ANXA4	P09525	261	302	2	319	Chain	ID=PRO_0000067482;Note=Annexin A4
ANXA4	P09525	261	302	254	314	Repeat	Note=Annexin 4
ANXA4	P09525	261	302	293	293	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA4	P09525	261	302	300	300	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA4	P09525	159	178	168	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZOC
ANXA4	P09525	261	302	259	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZOC
ANXA4	P09525	261	302	265	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZOC
ANXA4	P09525	261	302	276	279	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZOC
ANXA4	P09525	261	302	280	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZOC
ANXA4	P09525	261	302	295	302	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZOC
ANXA5	P08758	260	301	2	320	Chain	ID=PRO_0000067487;Note=Annexin A5
ANXA5	P08758	208	240	2	320	Chain	ID=PRO_0000067487;Note=Annexin A5
ANXA5	P08758	158	177	2	320	Chain	ID=PRO_0000067487;Note=Annexin A5
ANXA5	P08758	63	101	2	320	Chain	ID=PRO_0000067487;Note=Annexin A5
ANXA5	P08758	63	101	24	84	Repeat	Note=Annexin 1
ANXA5	P08758	63	101	96	156	Repeat	Note=Annexin 2
ANXA5	P08758	208	240	180	240	Repeat	Note=Annexin 3
ANXA5	P08758	260	301	255	315	Repeat	Note=Annexin 4
ANXA5	P08758	63	101	70	70	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA5	P08758	63	101	76	76	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA5	P08758	63	101	79	79	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA5	P08758	63	101	97	97	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
ANXA5	P08758	63	101	101	101	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:16916647;Dbxref=PMID:16916647
ANXA5	P08758	260	301	290	290	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48036
ANXA5	P08758	260	301	279	279	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANXA5	P08758	63	101	65	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	63	101	75	85	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	63	101	88	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	158	177	169	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	208	240	203	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	208	240	221	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	208	240	231	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	260	301	260	263	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	260	301	266	276	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	260	301	277	280	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	260	301	281	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
ANXA5	P08758	260	301	292	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HVG
ANXA5	P08758	260	301	296	303	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX
AP3M1	Q9Y2T2	148	194	1	418	Chain	ID=PRO_0000193781;Note=AP-3 complex subunit mu-1
AP3M1	Q9Y2T2	148	194	1	418	Chain	ID=PRO_0000193781;Note=AP-3 complex subunit mu-1
AP3M1	Q9Y2T2	148	194	176	417	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP3M1	Q9Y2T2	148	194	176	417	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP3M1	Q9Y2T2	148	194	160	160	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP3M1	Q9Y2T2	148	194	160	160	Sequence conflict	Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP5M1	Q9H0R1	240	316	1	490	Chain	ID=PRO_0000193795;Note=AP-5 complex subunit mu-1
AP5M1	Q9H0R1	240	316	206	476	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP5M1	Q9H0R1	240	316	241	284	Alternative sequence	ID=VSP_008407;Note=In isoform 2. CDLEGIMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSS->VRFFSGTCFIVLFNIWRKVKFASCILNNIFYFHLKQQFLNGRVM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AP5M1	Q9H0R1	240	316	285	490	Alternative sequence	ID=VSP_008408;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AP4M1	O00189	325	341	1	453	Chain	ID=PRO_0000193787;Note=AP-4 complex subunit mu-1
AP4M1	O00189	325	341	1	453	Chain	ID=PRO_0000193787;Note=AP-4 complex subunit mu-1
AP4M1	O00189	325	341	184	452	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP4M1	O00189	325	341	184	452	Domain	Note=MHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00404
AP4M1	O00189	325	341	338	338	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP4M1	O00189	325	341	338	338	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AP4M1	O00189	325	341	326	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L81
AP4M1	O00189	325	341	326	335	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L81
AP4M1	O00189	325	341	341	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L81
AP4M1	O00189	325	341	341	349	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L81
AP4S1	Q9Y587	75	98	1	144	Chain	ID=PRO_0000193820;Note=AP-4 complex subunit sigma-1
ANAPC16	Q96DE5	47	72	2	110	Chain	ID=PRO_0000089816;Note=Anaphase-promoting complex subunit 16
APBB2	Q92870	576	604	1	758	Chain	ID=PRO_0000076052;Note=Amyloid-beta A4 precursor protein-binding family B member 2
APBB2	Q92870	347	368	1	758	Chain	ID=PRO_0000076052;Note=Amyloid-beta A4 precursor protein-binding family B member 2
APBB2	Q92870	6	278	1	758	Chain	ID=PRO_0000076052;Note=Amyloid-beta A4 precursor protein-binding family B member 2
APBB2	Q92870	576	604	413	578	Domain	Note=PID 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBB2	Q92870	576	604	584	736	Domain	Note=PID 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148
APBB2	Q92870	6	278	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
APBB2	Q92870	6	278	160	160	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
APBB2	Q92870	347	368	1	548	Alternative sequence	ID=VSP_044232;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
APBB2	Q92870	6	278	1	548	Alternative sequence	ID=VSP_044232;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
APBB2	Q92870	6	278	278	278	Alternative sequence	ID=VSP_045042;Note=In isoform 4. T->TA;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
APBB2	Q92870	347	368	348	368	Alternative sequence	ID=VSP_040354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB2	Q92870	576	604	577	577	Alternative sequence	ID=VSP_040355;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
APBB2	Q92870	6	278	179	179	Natural variant	ID=VAR_069029;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs4861358,PMID:15489334
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	1	121	Chain	ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	27	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
ANAPC15	P60006	40	60	49	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05
AP3B1	O00203	491	550	1	1094	Chain	ID=PRO_0000193746;Note=AP-3 complex subunit beta-1
AP3B1	O00203	365	389	1	1094	Chain	ID=PRO_0000193746;Note=AP-3 complex subunit beta-1
AP3B1	O00203	68	93	1	1094	Chain	ID=PRO_0000193746;Note=AP-3 complex subunit beta-1
AP3B1	O00203	365	389	379	379	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1	Q8N556	182	242	1	730	Chain	ID=PRO_0000317658;Note=Actin filament-associated protein 1
AFAP1	Q8N556	182	242	1	730	Chain	ID=PRO_0000317658;Note=Actin filament-associated protein 1
AFAP1	Q8N556	182	242	153	249	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AFAP1	Q8N556	182	242	153	249	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AFAP1	Q8N556	182	242	197	197	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1	Q8N556	182	242	197	197	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1	Q8N556	182	242	223	223	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1	Q8N556	182	242	223	223	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1	Q8N556	182	242	238	238	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AFAP1	Q8N556	182	242	238	238	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
AIFM2	Q9BRQ8	256	323	2	373	Chain	ID=PRO_0000238922;Note=Apoptosis-inducing factor 2
AIFM2	Q9BRQ8	98	138	2	373	Chain	ID=PRO_0000238922;Note=Apoptosis-inducing factor 2
AIFM2	Q9BRQ8	256	323	2	373	Chain	ID=PRO_0000238922;Note=Apoptosis-inducing factor 2
AIFM2	Q9BRQ8	98	138	2	373	Chain	ID=PRO_0000238922;Note=Apoptosis-inducing factor 2
AIFM2	Q9BRQ8	256	323	285	285	Binding site	Note=6-hydroxy-FAD;Ontology_term=ECO:0000255;evidence=ECO:0000255
AIFM2	Q9BRQ8	256	323	285	285	Binding site	Note=6-hydroxy-FAD;Ontology_term=ECO:0000255;evidence=ECO:0000255
AIFM2	Q9BRQ8	98	138	99	138	Alternative sequence	ID=VSP_052047;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
AIFM2	Q9BRQ8	98	138	99	138	Alternative sequence	ID=VSP_052047;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
AIFM2	Q9BRQ8	98	138	135	135	Natural variant	ID=VAR_050651;Note=M->T;Dbxref=dbSNP:rs10999147
AIFM2	Q9BRQ8	98	138	135	135	Natural variant	ID=VAR_050651;Note=M->T;Dbxref=dbSNP:rs10999147
AIFM2	Q9BRQ8	256	323	288	288	Natural variant	ID=VAR_050652;Note=D->N;Dbxref=dbSNP:rs2271694
AIFM2	Q9BRQ8	256	323	288	288	Natural variant	ID=VAR_050652;Note=D->N;Dbxref=dbSNP:rs2271694
AKIP1	Q9NQ31	74	101	1	210	Chain	ID=PRO_0000064857;Note=A-kinase-interacting protein 1
AKIP1	Q9NQ31	136	163	1	210	Chain	ID=PRO_0000064857;Note=A-kinase-interacting protein 1
AKIP1	Q9NQ31	74	101	1	210	Chain	ID=PRO_0000064857;Note=A-kinase-interacting protein 1
AKIP1	Q9NQ31	136	163	1	210	Chain	ID=PRO_0000064857;Note=A-kinase-interacting protein 1
AKIP1	Q9NQ31	74	101	75	101	Alternative sequence	ID=VSP_013275;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12527432;Dbxref=PMID:12527432
AKIP1	Q9NQ31	74	101	75	101	Alternative sequence	ID=VSP_013275;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12527432;Dbxref=PMID:12527432
AKIP1	Q9NQ31	136	163	137	163	Alternative sequence	ID=VSP_013276;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12527432;Dbxref=PMID:12527432
AKIP1	Q9NQ31	136	163	137	163	Alternative sequence	ID=VSP_013276;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12527432;Dbxref=PMID:12527432
AKIP1	Q9NQ31	74	101	92	92	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKIP1	Q9NQ31	74	101	92	92	Sequence conflict	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
AIP	O00170	33	93	1	330	Chain	ID=PRO_0000075339;Note=AH receptor-interacting protein
AIP	O00170	93	156	1	330	Chain	ID=PRO_0000075339;Note=AH receptor-interacting protein
AIP	O00170	33	93	31	121	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
AIP	O00170	93	156	31	121	Domain	Note=PPIase FKBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00277
AIP	O00170	33	93	43	43	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
AIP	O00170	33	93	47	54	Natural variant	ID=VAR_058407;Note=In PITA1%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17244780;Dbxref=PMID:17244780
AIP	O00170	33	93	33	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	39	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	43	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	49	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	54	57	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	60	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	72	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	85	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	33	93	92	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	92	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	98	105	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	113	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	137	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	140	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
AIP	O00170	93	156	149	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LKN
ALDH8A1	Q9H2A2	283	337	1	487	Chain	ID=PRO_0000312954;Note=Aldehyde dehydrogenase family 8 member A1
ALDH8A1	Q9H2A2	147	197	1	487	Chain	ID=PRO_0000312954;Note=Aldehyde dehydrogenase family 8 member A1
ALDH8A1	Q9H2A2	283	337	287	287	Active site	Note=Nucleophile;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10007,ECO:0000255|PROSITE-ProRule:PRU10008
ALDH8A1	Q9H2A2	147	197	155	155	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDH8A1	Q9H2A2	147	197	148	197	Alternative sequence	ID=VSP_043279;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALDH8A1	Q9H2A2	147	197	148	160	Alternative sequence	ID=VSP_039759;Note=In isoform 3. AGLISPWNLPLYL->VPGYTCRTCRFVT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALDH8A1	Q9H2A2	283	337	161	487	Alternative sequence	ID=VSP_039760;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALDH8A1	Q9H2A2	147	197	161	487	Alternative sequence	ID=VSP_039760;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALDH8A1	Q9H2A2	283	337	284	337	Alternative sequence	ID=VSP_029972;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11007799,ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:11007799,PMID:14702039
ALDH1L1	O75891	408	448	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	286	328	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	240	286	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	176	210	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	408	448	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	286	328	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	240	286	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	176	210	1	902	Chain	ID=PRO_0000199419;Note=Cytosolic 10-formyltetrahydrofolate dehydrogenase
ALDH1L1	O75891	286	328	318	395	Domain	Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258
ALDH1L1	O75891	286	328	318	395	Domain	Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258
ALDH1L1	O75891	176	210	1	203	Region	Note=GART
ALDH1L1	O75891	176	210	1	203	Region	Note=GART
ALDH1L1	O75891	408	448	417	902	Region	Note=Aldehyde dehydrogenase
ALDH1L1	O75891	408	448	417	902	Region	Note=Aldehyde dehydrogenase
ALDH1L1	O75891	176	210	118	218	Alternative sequence	ID=VSP_045569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALDH1L1	O75891	176	210	118	218	Alternative sequence	ID=VSP_045569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALDH1L1	O75891	240	286	254	254	Natural variant	ID=VAR_052290;Note=L->P;Dbxref=dbSNP:rs3796191
ALDH1L1	O75891	240	286	254	254	Natural variant	ID=VAR_052290;Note=L->P;Dbxref=dbSNP:rs3796191
ALDH1L1	O75891	408	448	429	429	Natural variant	ID=VAR_052292;Note=E->A;Dbxref=dbSNP:rs9282691
ALDH1L1	O75891	408	448	429	429	Natural variant	ID=VAR_052292;Note=E->A;Dbxref=dbSNP:rs9282691
ALDH1L1	O75891	408	448	436	436	Natural variant	ID=VAR_052293;Note=A->T;Dbxref=dbSNP:rs9282692
ALDH1L1	O75891	408	448	436	436	Natural variant	ID=VAR_052293;Note=A->T;Dbxref=dbSNP:rs9282692
ALDH1L1	O75891	408	448	448	448	Natural variant	ID=VAR_052295;Note=S->N;Dbxref=dbSNP:rs9282697
ALDH1L1	O75891	408	448	448	448	Natural variant	ID=VAR_052295;Note=S->N;Dbxref=dbSNP:rs9282697
ALDH1L1	O75891	176	210	176	176	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH1L1	O75891	176	210	176	176	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH1L1	O75891	176	210	195	195	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH1L1	O75891	176	210	195	195	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH1L1	O75891	176	210	170	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	176	210	170	185	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	176	210	206	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	176	210	206	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	240	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	240	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	258	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	258	261	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	270	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	270	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	276	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	276	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	286	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	286	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	286	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	240	286	286	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	299	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	299	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BW0
ALDH1L1	O75891	286	328	320	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQ8
ALDH1L1	O75891	286	328	320	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQ8
ALG5	Q9Y673	187	207	1	324	Chain	ID=PRO_0000059098;Note=Dolichyl-phosphate beta-glucosyltransferase
ALG5	Q9Y673	149	187	1	324	Chain	ID=PRO_0000059098;Note=Dolichyl-phosphate beta-glucosyltransferase
ALG5	Q9Y673	118	149	1	324	Chain	ID=PRO_0000059098;Note=Dolichyl-phosphate beta-glucosyltransferase
ALG5	Q9Y673	187	207	29	324	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG5	Q9Y673	149	187	29	324	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG5	Q9Y673	118	149	29	324	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG5	Q9Y673	118	149	95	124	Alternative sequence	ID=VSP_041019;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LAP3	P28838	180	234	1	519	Chain	ID=PRO_0000165825;Note=Cytosol aminopeptidase
LAP3	P28838	180	234	180	180	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CPY7
LAP3	P28838	180	234	194	194	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
LAP3	P28838	180	234	221	221	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LAP3	P28838	180	234	221	221	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9CPY7
ADCY8	P40145	971	1020	1	1251	Chain	ID=PRO_0000195705;Note=Adenylate cyclase type 8
ADCY8	P40145	804	834	1	1251	Chain	ID=PRO_0000195705;Note=Adenylate cyclase type 8
ADCY8	P40145	637	703	1	1251	Chain	ID=PRO_0000195705;Note=Adenylate cyclase type 8
ADCY8	P40145	637	703	342	715	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY8	P40145	804	834	787	807	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY8	P40145	804	834	831	851	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY8	P40145	971	1020	915	1251	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY8	P40145	804	834	817	817	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADCY8	P40145	804	834	821	821	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADNP	Q9H2P0	36	67	1	1102	Chain	ID=PRO_0000048807;Note=Activity-dependent neuroprotector homeobox protein
ADNP	Q9H2P0	36	67	1	1102	Chain	ID=PRO_0000048807;Note=Activity-dependent neuroprotector homeobox protein
ADNP	Q9H2P0	36	67	1	1102	Chain	ID=PRO_0000048807;Note=Activity-dependent neuroprotector homeobox protein
ADNP	Q9H2P0	36	67	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ADNP	Q9H2P0	36	67	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
ADNP	Q9H2P0	36	67	39	39	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
AEBP2	Q6ZN18	293	329	2	517	Chain	ID=PRO_0000341590;Note=Zinc finger protein AEBP2
AEBP2	Q6ZN18	456	493	2	517	Chain	ID=PRO_0000341590;Note=Zinc finger protein AEBP2
AEBP2	Q6ZN18	293	329	300	322	Zinc finger	Note=C2H2-type 2%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
AEBP2	Q6ZN18	293	329	328	352	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
AEBP2	Q6ZN18	293	329	209	294	Region	Note=Interaction with RBBP4
AEBP2	Q6ZN18	456	493	353	517	Region	Note=Interaction with SUZ12
AEBP2	Q6ZN18	456	493	455	457	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AEBP2	Q6ZN18	456	493	460	463	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AEBP2	Q6ZN18	456	493	464	467	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AEBP2	Q6ZN18	456	493	471	476	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AEBP2	Q6ZN18	456	493	477	479	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AEBP2	Q6ZN18	456	493	482	485	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AEBP2	Q6ZN18	456	493	486	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WAI
AKAP6	Q13023	782	823	1	2319	Chain	ID=PRO_0000064530;Note=A-kinase anchor protein 6
AKAP6	Q13023	782	823	762	848	Repeat	Note=Spectrin 1
ALDH1L2	Q3SY69	715	748	1	923	Chain	ID=PRO_0000316001;Note=Mitochondrial 10-formyltetrahydrofolate dehydrogenase
ALDH1L2	Q3SY69	429	469	1	923	Chain	ID=PRO_0000316001;Note=Mitochondrial 10-formyltetrahydrofolate dehydrogenase
ALDH1L2	Q3SY69	715	748	438	923	Region	Note=Aldehyde dehydrogenase
ALDH1L2	Q3SY69	429	469	438	923	Region	Note=Aldehyde dehydrogenase
ALDH1L2	Q3SY69	715	748	728	728	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDH1L2	Q3SY69	715	748	204	923	Alternative sequence	ID=VSP_030753;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALDH1L2	Q3SY69	429	469	204	923	Alternative sequence	ID=VSP_030753;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALDH1L2	Q3SY69	715	748	517	923	Alternative sequence	ID=VSP_030755;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
AKR1A1	P14550	28	68	2	325	Chain	ID=PRO_0000124617;Note=Alcohol dehydrogenase [NADP(+)]
AKR1A1	P14550	275	304	2	325	Chain	ID=PRO_0000124617;Note=Alcohol dehydrogenase [NADP(+)]
AKR1A1	P14550	28	68	2	325	Chain	ID=PRO_0000124617;Note=Alcohol dehydrogenase [NADP(+)]
AKR1A1	P14550	275	304	2	325	Chain	ID=PRO_0000124617;Note=Alcohol dehydrogenase [NADP(+)]
AKR1A1	P14550	28	68	50	50	Active site	Note=Proton donor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	28	68	50	50	Active site	Note=Proton donor;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	28	68	45	45	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60218
AKR1A1	P14550	28	68	45	45	Binding site	Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60218
AKR1A1	P14550	28	68	38	38	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
AKR1A1	P14550	28	68	38	38	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
AKR1A1	P14550	28	68	52	52	Natural variant	ID=VAR_048212;Note=Reduced activity towards daunorubicin. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18276838;Dbxref=dbSNP:rs2229540,PMID:18276838
AKR1A1	P14550	28	68	52	52	Natural variant	ID=VAR_048212;Note=Reduced activity towards daunorubicin. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18276838;Dbxref=dbSNP:rs2229540,PMID:18276838
AKR1A1	P14550	28	68	55	55	Natural variant	ID=VAR_058909;Note=Reduced activity towards daunorubicin. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18276838;Dbxref=dbSNP:rs6690497,PMID:18276838
AKR1A1	P14550	28	68	55	55	Natural variant	ID=VAR_058909;Note=Reduced activity towards daunorubicin. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18276838;Dbxref=dbSNP:rs6690497,PMID:18276838
AKR1A1	P14550	28	68	50	50	Mutagenesis	Note=Complete loss of enzymatic activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	28	68	50	50	Mutagenesis	Note=Complete loss of enzymatic activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	28	68	50	50	Mutagenesis	Note=Complete loss of enzymatic activity. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	28	68	50	50	Mutagenesis	Note=Complete loss of enzymatic activity. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	275	304	299	299	Mutagenesis	Note=No change in enzymatic activity. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	275	304	299	299	Mutagenesis	Note=No change in enzymatic activity. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	275	304	299	299	Mutagenesis	Note=No change in enzymatic activity. I->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	275	304	299	299	Mutagenesis	Note=No change in enzymatic activity. I->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	275	304	300	300	Mutagenesis	Note=No change in enzymatic activity. V->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	275	304	300	300	Mutagenesis	Note=No change in enzymatic activity. V->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7669785;Dbxref=PMID:7669785
AKR1A1	P14550	28	68	26	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	26	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	43	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	43	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	48	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	48	50	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	53	63	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	28	68	68	70	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	275	304	283	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	275	304	283	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	275	304	302	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
AKR1A1	P14550	275	304	302	305	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ALR
ALKBH8	Q96BT7	429	479	1	664	Chain	ID=PRO_0000337125;Note=Alkylated DNA repair protein alkB homolog 8
ALKBH8	Q96BT7	429	479	1	664	Chain	ID=PRO_0000337125;Note=Alkylated DNA repair protein alkB homolog 8
ALKBH8	Q96BT7	429	479	411	664	Region	Note=Methyltransferase domain
ALKBH8	Q96BT7	429	479	411	664	Region	Note=Methyltransferase domain
ALKBH8	Q96BT7	429	479	225	664	Alternative sequence	ID=VSP_033926;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALKBH8	Q96BT7	429	479	225	664	Alternative sequence	ID=VSP_033926;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALKBH8	Q96BT7	429	479	239	664	Alternative sequence	ID=VSP_033928;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ALKBH8	Q96BT7	429	479	239	664	Alternative sequence	ID=VSP_033928;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AMOT	Q4VCS5	706	746	1	1084	Chain	ID=PRO_0000190668;Note=Angiomotin
AMOT	Q4VCS5	706	746	1	1084	Chain	ID=PRO_0000190668;Note=Angiomotin
AMOT	Q4VCS5	706	746	721	751	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AMOT	Q4VCS5	706	746	721	751	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
AMOT	Q4VCS5	706	746	714	714	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VHG2
AMOT	Q4VCS5	706	746	714	714	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VHG2
AGO1	Q9UL18	216	261	1	857	Chain	ID=PRO_0000194055;Note=Protein argonaute-1
AGO1	Q9UL18	216	261	226	346	Domain	Note=PAZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00142
AGO1	Q9UL18	216	261	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AGO1	Q9UL18	216	261	208	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KRE
AGO1	Q9UL18	216	261	228	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KRE
AGO1	Q9UL18	216	261	241	243	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SI2
AGO1	Q9UL18	216	261	250	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KRE
AIMP1	Q12904	74	130	2	312	Chain	ID=PRO_0000223394;Note=Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
AIMP1	Q12904	74	130	2	312	Chain	ID=PRO_0000223394;Note=Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
AIMP1	Q12904	74	130	54	194	Region	Note=Interaction with HSP90B1;Ontology_term=ECO:0000250;evidence=ECO:0000250
AIMP1	Q12904	74	130	54	194	Region	Note=Interaction with HSP90B1;Ontology_term=ECO:0000250;evidence=ECO:0000250
AIMP1	Q12904	74	130	101	114	Region	Note=Required for endothelial cell death
AIMP1	Q12904	74	130	101	114	Region	Note=Required for endothelial cell death
AIMP1	Q12904	74	130	114	192	Region	Note=Required for endothelial cell migration
AIMP1	Q12904	74	130	114	192	Region	Note=Required for endothelial cell migration
AIMP1	Q12904	74	130	79	79	Natural variant	ID=VAR_025212;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7929199;Dbxref=dbSNP:rs1134648,PMID:7929199
AIMP1	Q12904	74	130	79	79	Natural variant	ID=VAR_025212;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7929199;Dbxref=dbSNP:rs1134648,PMID:7929199
AIMP1	Q12904	74	130	104	104	Natural variant	ID=VAR_029156;Note=T->A;Dbxref=dbSNP:rs113844295
AIMP1	Q12904	74	130	104	104	Natural variant	ID=VAR_029156;Note=T->A;Dbxref=dbSNP:rs113844295
AIMP1	Q12904	74	130	117	117	Natural variant	ID=VAR_050124;Note=T->A;Dbxref=dbSNP:rs2230255
AIMP1	Q12904	74	130	117	117	Natural variant	ID=VAR_050124;Note=T->A;Dbxref=dbSNP:rs2230255
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKR1C2	P52895	123	149	1	323	Chain	ID=PRO_0000124637;Note=Aldo-keto reductase family 1 member C2
AKR1C2	P52895	84	123	1	323	Chain	ID=PRO_0000124637;Note=Aldo-keto reductase family 1 member C2
AKR1C2	P52895	84	123	117	117	Binding site	Note=Substrate
AKR1C2	P52895	84	123	84	84	Site	Note=Lowers pKa of active site Tyr;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKR1C2	P52895	123	149	124	139	Alternative sequence	ID=VSP_043779;Note=In isoform 2. PGEEVIPKDENGKILF->EDIGILTWKKSPKHNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKR1C2	P52895	123	149	140	323	Alternative sequence	ID=VSP_043780;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKR1C2	P52895	84	123	90	90	Natural variant	ID=VAR_066633;Note=In SRXY8%3B partially impaired activity. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21802064;Dbxref=dbSNP:rs797044460,PMID:21802064
AKR1C2	P52895	84	123	87	87	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1C2	P52895	84	123	93	93	Sequence conflict	Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1C2	P52895	84	123	111	111	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1C2	P52895	84	123	80	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XO6
AKR1C2	P52895	84	123	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XO6
AKR1C2	P52895	84	123	92	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XO6
AKR1C2	P52895	84	123	111	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XO6
AKR1C2	P52895	84	123	119	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JQA
AKR1C2	P52895	123	149	124	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JQA
AKR1C2	P52895	123	149	144	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XO6
ALDOC	P09972	180	208	1	364	Chain	ID=PRO_0000216947;Note=Fructose-bisphosphate aldolase C
ALDOC	P09972	180	208	1	364	Chain	ID=PRO_0000216947;Note=Fructose-bisphosphate aldolase C
ALDOC	P09972	180	208	188	188	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDOC	P09972	180	208	188	188	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDOC	P09972	180	208	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XFB
ALDOC	P09972	180	208	180	182	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XFB
ALDOC	P09972	180	208	184	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XFB
ALDOC	P09972	180	208	184	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XFB
ALDOC	P09972	180	208	199	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XFB
ALDOC	P09972	180	208	199	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XFB
ALPK1	Q96QP1	158	178	1	1244	Chain	ID=PRO_0000260028;Note=Alpha-protein kinase 1
ALPK1	Q96QP1	265	300	1	1244	Chain	ID=PRO_0000260028;Note=Alpha-protein kinase 1
ALPK1	Q96QP1	158	178	1	1244	Chain	ID=PRO_0000260028;Note=Alpha-protein kinase 1
ALPK1	Q96QP1	265	300	1	1244	Chain	ID=PRO_0000260028;Note=Alpha-protein kinase 1
ALPK1	Q96QP1	265	300	295	295	Binding site	Note=ADP-D-glycero-beta-D-manno-heptose;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836
ALPK1	Q96QP1	265	300	295	295	Binding site	Note=ADP-D-glycero-beta-D-manno-heptose;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836
ALPK1	Q96QP1	158	178	175	175	Natural variant	ID=VAR_028982;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs6533616,PMID:17344846
ALPK1	Q96QP1	158	178	175	175	Natural variant	ID=VAR_028982;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs6533616,PMID:17344846
ALPK1	Q96QP1	265	300	292	292	Natural variant	ID=VAR_041512;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34120296,PMID:17344846
ALPK1	Q96QP1	265	300	292	292	Natural variant	ID=VAR_041512;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34120296,PMID:17344846
ALPK1	Q96QP1	265	300	295	295	Mutagenesis	Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity%3B when associated with E-237. F->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836
ALPK1	Q96QP1	265	300	295	295	Mutagenesis	Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity%3B when associated with E-237. F->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836
ANGPTL3	Q9Y5C1	278	310	17	460	Chain	ID=PRO_0000009122;Note=Angiopoietin-related protein 3
ANGPTL3	Q9Y5C1	310	399	17	460	Chain	ID=PRO_0000009122;Note=Angiopoietin-related protein 3
ANGPTL3	Q9Y5C1	278	310	237	455	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
ANGPTL3	Q9Y5C1	310	399	237	455	Domain	Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
ANGPTL3	Q9Y5C1	278	310	296	296	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218;Dbxref=PMID:16335952,PMID:19159218
ANGPTL3	Q9Y5C1	310	399	357	357	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
ANGPTL3	Q9Y5C1	310	399	394	408	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739
ANGPTL3	Q9Y5C1	278	310	288	288	Natural variant	ID=VAR_075675;Note=Abolishes protein secretion%3B associated with low plasma triglyceride level. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19075393;Dbxref=dbSNP:rs763904695,PMID:19075393
ANGPTL3	Q9Y5C1	278	310	288	288	Natural variant	ID=VAR_075676;Note=Abolishes protein secretion%3B associated with low plasma triglyceride level. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19075393;Dbxref=PMID:19075393
ANGPTL3	Q9Y5C1	278	310	292	292	Natural variant	ID=VAR_075677;Note=Abolishes protein secretion%3B associated with low plasma triglyceride level. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19075393;Dbxref=dbSNP:rs138899888,PMID:19075393
ANGPTL3	Q9Y5C1	310	399	344	344	Natural variant	ID=VAR_075678;Note=Abolishes protein secretion%3B associated with low plasma triglyceride level. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25733326;Dbxref=dbSNP:rs1334979946,PMID:25733326
ANGPTL3	Q9Y5C1	310	399	375	375	Natural variant	ID=VAR_075679;Note=Abolishes protein secretion%3B associated with low plasma triglyceride level. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19075393,ECO:0000269|PubMed:25733326;Dbxref=dbSNP:rs768802285,PMID:19075393,PMID:25733326
ANGPTL3	Q9Y5C1	278	310	280	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	278	310	299	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	278	310	306	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	311	314	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	317	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	329	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	342	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	354	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	360	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	375	377	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	379	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	395	397	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANGPTL3	Q9Y5C1	310	399	398	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6EUA
ANKRD6	Q9Y2G4	40	73	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	106	139	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	139	172	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	172	205	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	238	264	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	371	422	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	422	460	1	727	Chain	ID=PRO_0000066901;Note=Ankyrin repeat domain-containing protein 6
ANKRD6	Q9Y2G4	40	73	41	70	Repeat	Note=ANK 2
ANKRD6	Q9Y2G4	106	139	107	136	Repeat	Note=ANK 4
ANKRD6	Q9Y2G4	139	172	140	169	Repeat	Note=ANK 5
ANKRD6	Q9Y2G4	172	205	173	202	Repeat	Note=ANK 6
ANKRD6	Q9Y2G4	238	264	239	268	Repeat	Note=ANK 8
ANKRD6	Q9Y2G4	371	422	417	446	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD6	Q9Y2G4	422	460	417	446	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ANKRD6	Q9Y2G4	371	422	382	385	Compositional bias	Note=Poly-Pro
ANKRD6	Q9Y2G4	106	139	106	138	Alternative sequence	ID=VSP_043189;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD6	Q9Y2G4	238	264	239	264	Alternative sequence	ID=VSP_043190;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ANKRD6	Q9Y2G4	106	139	122	122	Natural variant	ID=VAR_039114;Note=Q->E;Dbxref=dbSNP:rs16881983
ANKRD6	Q9Y2G4	106	139	128	128	Natural variant	ID=VAR_039115;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10231032,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs3748085,PMID:10231032,PMID:15489334,PMID:17974005
ANXA2	P07355	279	320	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	227	259	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	176	196	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	81	119	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	279	320	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	227	259	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	176	196	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	81	119	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	279	320	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	227	259	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	176	196	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	81	119	2	339	Chain	ID=PRO_0000067470;Note=Annexin A2
ANXA2	P07355	81	119	42	102	Repeat	Note=Annexin 1
ANXA2	P07355	81	119	42	102	Repeat	Note=Annexin 1
ANXA2	P07355	81	119	42	102	Repeat	Note=Annexin 1
ANXA2	P07355	81	119	114	174	Repeat	Note=Annexin 2
ANXA2	P07355	81	119	114	174	Repeat	Note=Annexin 2
ANXA2	P07355	81	119	114	174	Repeat	Note=Annexin 2
ANXA2	P07355	227	259	199	259	Repeat	Note=Annexin 3
ANXA2	P07355	227	259	199	259	Repeat	Note=Annexin 3
ANXA2	P07355	227	259	199	259	Repeat	Note=Annexin 3
ANXA2	P07355	279	320	274	334	Repeat	Note=Annexin 4
ANXA2	P07355	279	320	274	334	Repeat	Note=Annexin 4
ANXA2	P07355	279	320	274	334	Repeat	Note=Annexin 4
ANXA2	P07355	176	196	184	184	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ANXA2	P07355	176	196	184	184	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ANXA2	P07355	176	196	184	184	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ANXA2	P07355	227	259	227	227	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356
ANXA2	P07355	227	259	227	227	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356
ANXA2	P07355	227	259	227	227	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07356
ANXA2	P07355	81	119	98	98	Natural variant	ID=VAR_012982;Note=Polymorphism%3B does not affect interaction with PCSK9. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:22848640;Dbxref=dbSNP:rs17845226,PMID:15489334,PMID:22848640
ANXA2	P07355	81	119	98	98	Natural variant	ID=VAR_012982;Note=Polymorphism%3B does not affect interaction with PCSK9. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:22848640;Dbxref=dbSNP:rs17845226,PMID:15489334,PMID:22848640
ANXA2	P07355	81	119	98	98	Natural variant	ID=VAR_012982;Note=Polymorphism%3B does not affect interaction with PCSK9. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:22848640;Dbxref=dbSNP:rs17845226,PMID:15489334,PMID:22848640
ANXA2	P07355	81	119	77	81	Mutagenesis	Note=Strongly decreases interaction with PCSK9. RRTKK->AATAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18799458,ECO:0000269|PubMed:22848640;Dbxref=PMID:18799458,PMID:22848640
ANXA2	P07355	81	119	77	81	Mutagenesis	Note=Strongly decreases interaction with PCSK9. RRTKK->AATAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18799458,ECO:0000269|PubMed:22848640;Dbxref=PMID:18799458,PMID:22848640
ANXA2	P07355	81	119	77	81	Mutagenesis	Note=Strongly decreases interaction with PCSK9. RRTKK->AATAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18799458,ECO:0000269|PubMed:22848640;Dbxref=PMID:18799458,PMID:22848640
ANXA2	P07355	81	119	80	84	Mutagenesis	Note=No effect on interaction with PCSK9. KKELA->GKPLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458
ANXA2	P07355	81	119	80	84	Mutagenesis	Note=No effect on interaction with PCSK9. KKELA->GKPLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458
ANXA2	P07355	81	119	80	84	Mutagenesis	Note=No effect on interaction with PCSK9. KKELA->GKPLD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458
ANXA2	P07355	81	119	88	88	Mutagenesis	Note=Strongly decreases interaction with PCSK9%3B when associated with 77-A--A-80. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458
ANXA2	P07355	81	119	88	88	Mutagenesis	Note=Strongly decreases interaction with PCSK9%3B when associated with 77-A--A-80. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458
ANXA2	P07355	81	119	88	88	Mutagenesis	Note=Strongly decreases interaction with PCSK9%3B when associated with 77-A--A-80. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799458;Dbxref=PMID:18799458
ANXA2	P07355	279	320	293	293	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANXA2	P07355	279	320	293	293	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANXA2	P07355	279	320	293	293	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ANXA2	P07355	81	119	83	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	83	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	83	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	93	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	93	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	93	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	81	119	106	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	176	196	188	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	176	196	188	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	176	196	188	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	222	232	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	233	235	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	240	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	240	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	240	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	250	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	250	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	227	259	250	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	279	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	279	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	279	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	285	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	285	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	285	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	300	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	300	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	300	311	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	315	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	315	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ANXA2	P07355	279	320	315	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYV
ADAP2	Q9NPF8	170	219	1	381	Chain	ID=PRO_0000074206;Note=Arf-GAP with dual PH domain-containing protein 2
ADAP2	Q9NPF8	219	247	1	381	Chain	ID=PRO_0000074206;Note=Arf-GAP with dual PH domain-containing protein 2
ADAP2	Q9NPF8	247	268	1	381	Chain	ID=PRO_0000074206;Note=Arf-GAP with dual PH domain-containing protein 2
ADAP2	Q9NPF8	268	294	1	381	Chain	ID=PRO_0000074206;Note=Arf-GAP with dual PH domain-containing protein 2
ADAP2	Q9NPF8	170	219	132	233	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ADAP2	Q9NPF8	219	247	132	233	Domain	Note=PH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ADAP2	Q9NPF8	247	268	255	361	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ADAP2	Q9NPF8	268	294	255	361	Domain	Note=PH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
ADAP2	Q9NPF8	268	294	269	269	Alternative sequence	ID=VSP_011180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ADAM33	Q9BZ11	635	661	204	813	Chain	ID=PRO_0000029143;Note=Disintegrin and metalloproteinase domain-containing protein 33
ADAM33	Q9BZ11	635	661	30	701	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM33	Q9BZ11	635	661	649	681	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
ADAM33	Q9BZ11	635	661	503	648	Compositional bias	Note=Cys-rich
ADAM33	Q9BZ11	635	661	653	663	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAM33	Q9BZ11	635	661	657	669	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAM33	Q9BZ11	635	661	636	661	Alternative sequence	ID=VSP_005495;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11814695;Dbxref=PMID:11814695
ADAM19	Q9H013	636	662	203	955	Chain	ID=PRO_0000029103;Note=Disintegrin and metalloproteinase domain-containing protein 19
ADAM19	Q9H013	222	246	203	955	Chain	ID=PRO_0000029103;Note=Disintegrin and metalloproteinase domain-containing protein 19
ADAM19	Q9H013	636	662	203	699	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM19	Q9H013	222	246	203	699	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM19	Q9H013	222	246	210	408	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM19	Q9H013	636	662	650	682	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
ADAM19	Q9H013	636	662	502	649	Compositional bias	Note=Cys-rich
ADAM19	Q9H013	636	662	645	645	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM19	Q9H013	636	662	654	664	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
ADAM19	Q9H013	636	662	658	670	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
AFF1	P51825	361	390	1	1210	Chain	ID=PRO_0000215910;Note=AF4/FMR2 family member 1
AFF1	P51825	1051	1096	1	1210	Chain	ID=PRO_0000215910;Note=AF4/FMR2 family member 1
AFF1	P51825	1051	1096	1096	1096	Alternative sequence	ID=VSP_046096;Note=In isoform 2 and isoform 3. A->AR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8443374;Dbxref=PMID:14702039,PMID:8443374
AGR3	Q8TD06	122	150	22	166	Chain	ID=PRO_0000001040;Note=Anterior gradient protein 3
AGR3	Q8TD06	122	150	116	122	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PH9
AGR3	Q8TD06	122	150	145	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PH9
AGR3	Q8TD06	122	150	148	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PH9
AKR1D1	P51857	31	87	1	326	Chain	ID=PRO_0000124669;Note=3-oxo-5-beta-steroid 4-dehydrogenase
AKR1D1	P51857	87	126	1	326	Chain	ID=PRO_0000124669;Note=3-oxo-5-beta-steroid 4-dehydrogenase
AKR1D1	P51857	152	193	1	326	Chain	ID=PRO_0000124669;Note=3-oxo-5-beta-steroid 4-dehydrogenase
AKR1D1	P51857	152	193	169	170	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18624455,ECO:0000269|PubMed:18848863,ECO:0000269|PubMed:19075558,ECO:0000269|PubMed:19515843,ECO:0000269|PubMed:22437839;Dbxref=PMID:18624455,PMID:18848863,PMID:19075558,PMID:19515843,PMID:22437839
AKR1D1	P51857	31	87	58	58	Active site	Note=Proton donor
AKR1D1	P51857	31	87	53	53	Binding site	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18624455,ECO:0000269|PubMed:18848863,ECO:0000269|PubMed:19075558,ECO:0000269|PubMed:19515843,ECO:0000269|PubMed:22437839;Dbxref=PMID:18624455,PMID:18848863,PMID:19075558,PMID:19515843,PMID:22437839
AKR1D1	P51857	31	87	58	58	Binding site	Note=Substrate
AKR1D1	P51857	87	126	89	89	Binding site	Note=Substrate
AKR1D1	P51857	87	126	120	120	Binding site	Note=Substrate
AKR1D1	P51857	152	193	193	193	Binding site	Note=NADP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18624455,ECO:0000269|PubMed:18848863,ECO:0000269|PubMed:19075558,ECO:0000269|PubMed:19515843,ECO:0000269|PubMed:22437839;Dbxref=PMID:18624455,PMID:18848863,PMID:19075558,PMID:19515843,PMID:22437839
AKR1D1	P51857	152	193	153	193	Alternative sequence	ID=VSP_042913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKR1D1	P51857	87	126	106	106	Natural variant	ID=VAR_033007;Note=In CBAS2. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12970144;Dbxref=dbSNP:rs121918343,PMID:12970144
AKR1D1	P51857	31	87	58	58	Mutagenesis	Note=Loss of activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18407998;Dbxref=PMID:18407998
AKR1D1	P51857	87	126	120	120	Mutagenesis	Note=Loss of activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18407998;Dbxref=PMID:18407998
AKR1D1	P51857	31	87	29	31	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	31	87	36	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	31	87	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	31	87	56	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	31	87	61	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	31	87	79	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	31	87	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	87	126	83	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	87	126	90	92	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	87	126	95	97	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	87	126	98	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	87	126	114	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	152	193	147	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	152	193	162	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	152	193	173	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AKR1D1	P51857	152	193	191	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BUV
AIF1L	Q9BQI0	53	67	2	150	Chain	ID=PRO_0000073870;Note=Allograft inflammatory factor 1-like
AIF1L	Q9BQI0	53	67	47	82	Domain	Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
AIF1L	Q9BQI0	53	67	60	71	Calcium binding	Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
AIF1L	Q9BQI0	53	67	60	67	Alternative sequence	ID=VSP_017151;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AIF1L	Q9BQI0	53	67	45	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJZ
AIF1L	Q9BQI0	53	67	65	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JJZ
AKAP10	O43572	489	547	29	662	Chain	ID=PRO_0000030404;Note=A-kinase anchor protein 10%2C mitochondrial
AKAP10	O43572	292	325	29	662	Chain	ID=PRO_0000030404;Note=A-kinase anchor protein 10%2C mitochondrial
AKAP10	O43572	45	106	29	662	Chain	ID=PRO_0000030404;Note=A-kinase anchor protein 10%2C mitochondrial
AKAP10	O43572	292	325	125	369	Domain	Note=RGS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
AKAP10	O43572	489	547	379	505	Domain	Note=RGS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00171
AKAP10	O43572	45	106	52	52	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
AKAP10	O43572	489	547	524	524	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH1A3	P47895	68	115	2	512	Chain	ID=PRO_0000056478;Note=Aldehyde dehydrogenase family 1 member A3
ALDH1A3	P47895	179	222	2	512	Chain	ID=PRO_0000056478;Note=Aldehyde dehydrogenase family 1 member A3
ALDH1A3	P47895	356	411	2	512	Chain	ID=PRO_0000056478;Note=Aldehyde dehydrogenase family 1 member A3
ALDH1A3	P47895	179	222	204	204	Binding site	Note=NAD;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5FHZ,ECO:0000269|PubMed:27759097;Dbxref=PMID:27759097
ALDH1A3	P47895	179	222	207	207	Binding site	Note=NAD;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5FHZ,ECO:0000269|PubMed:27759097;Dbxref=PMID:27759097
ALDH1A3	P47895	356	411	361	361	Binding site	Note=NAD;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5FHZ,ECO:0000269|PubMed:27759097;Dbxref=PMID:27759097
ALDH1A3	P47895	356	411	411	411	Binding site	Note=NAD;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5FHZ,ECO:0000269|PubMed:27759097;Dbxref=PMID:27759097
ALDH1A3	P47895	179	222	181	181	Site	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250
ALDH1A3	P47895	68	115	71	71	Natural variant	ID=VAR_072332;Note=In MCOP8. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23881059;Dbxref=dbSNP:rs386834230,PMID:23881059
ALDH1A3	P47895	68	115	89	89	Natural variant	ID=VAR_069322;Note=In MCOP8%3B does not affect ALDH1A3 expression%3B results in strongly reduced protein levels. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23312594;Dbxref=dbSNP:rs397514652,PMID:23312594
ALDH1A3	P47895	356	411	369	369	Natural variant	ID=VAR_069324;Note=In MCOP8. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23646827;Dbxref=PMID:23646827
ALDH1A3	P47895	356	411	382	382	Natural variant	ID=VAR_072335;Note=In MCOP8. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24777706;Dbxref=PMID:24777706
ALDH1A3	P47895	356	411	386	386	Natural variant	ID=VAR_019706;Note=M->V;Dbxref=dbSNP:rs3803430
ALDH1A3	P47895	356	411	411	411	Natural variant	ID=VAR_072336;Note=In MCOP8. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24777706;Dbxref=PMID:24777706
ALDH1A3	P47895	68	115	68	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	68	115	87	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	68	115	93	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	68	115	111	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	179	222	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	179	222	185	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	179	222	200	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	179	222	211	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	356	411	359	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	356	411	378	381	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	356	411	384	386	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	356	411	396	400	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
ALDH1A3	P47895	356	411	406	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FHZ
AKR1B10	O60218	78	117	1	316	Chain	ID=PRO_0000124632;Note=Aldo-keto reductase family 1 member B10
AKR1B10	O60218	117	143	1	316	Chain	ID=PRO_0000124632;Note=Aldo-keto reductase family 1 member B10
AKR1B10	O60218	143	184	1	316	Chain	ID=PRO_0000124632;Note=Aldo-keto reductase family 1 member B10
AKR1B10	O60218	143	184	160	161	Nucleotide binding	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18087047;Dbxref=PMID:18087047
AKR1B10	O60218	78	117	111	111	Binding site	Note=Substrate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18087047;Dbxref=PMID:18087047
AKR1B10	O60218	143	184	184	184	Binding site	Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18087047;Dbxref=PMID:18087047
AKR1B10	O60218	78	117	78	78	Site	Note=Lowers pKa of active site Tyr;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14550
AKR1B10	O60218	117	143	125	125	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
AKR1B10	O60218	78	117	87	87	Natural variant	ID=VAR_020077;Note=P->S;Dbxref=dbSNP:rs2303312
AKR1B10	O60218	117	143	125	125	Mutagenesis	Note=Increased affinity and reduced catalytic activity towards all-trans-retinaldehyde. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18087047;Dbxref=PMID:18087047
AKR1B10	O60218	78	117	100	100	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKR1B10	O60218	78	117	74	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	78	117	81	83	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WEV
AKR1B10	O60218	78	117	86	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	78	117	105	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	117	143	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WEV
AKR1B10	O60218	117	143	127	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	117	143	138	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	143	184	138	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	143	184	153	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	143	184	164	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
AKR1B10	O60218	143	184	181	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUA
ALDH2	P05091	73	120	18	517	Chain	ID=PRO_0000007168;Note=Aldehyde dehydrogenase%2C mitochondrial
ALDH2	P05091	73	120	73	73	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47738
ALDH2	P05091	73	120	78	78	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47738
ALDH2	P05091	73	120	74	120	Alternative sequence	ID=VSP_046715;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ALDH2	P05091	73	120	80	85	Sequence conflict	Note=VKAARA->REGRPG;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH2	P05091	73	120	101	101	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH2	P05091	73	120	116	116	Sequence conflict	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
ALDH2	P05091	73	120	73	86	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O04
ALDH2	P05091	73	120	92	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O04
ALDH2	P05091	73	120	98	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O04
ALDH2	P05091	73	120	116	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O04
ALG1	Q9BT22	210	246	1	464	Chain	ID=PRO_0000080249;Note=Chitobiosyldiphosphodolichol beta-mannosyltransferase
ALG1	Q9BT22	287	300	1	464	Chain	ID=PRO_0000080249;Note=Chitobiosyldiphosphodolichol beta-mannosyltransferase
ALG1	Q9BT22	300	320	1	464	Chain	ID=PRO_0000080249;Note=Chitobiosyldiphosphodolichol beta-mannosyltransferase
ALG1	Q9BT22	320	357	1	464	Chain	ID=PRO_0000080249;Note=Chitobiosyldiphosphodolichol beta-mannosyltransferase
ALG1	Q9BT22	210	246	24	464	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG1	Q9BT22	287	300	24	464	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG1	Q9BT22	300	320	24	464	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG1	Q9BT22	320	357	24	464	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG1	Q9BT22	210	246	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:23186163
ALG1	Q9BT22	287	300	289	289	Natural variant	ID=VAR_077196;Note=In CDG1K%3B decreased function in protein glycosylation as shown by rescue assays in an ALG1-deficient yeast strain. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26931382;Dbxref=PMID:26931382
ALG1	Q9BT22	287	300	291	291	Natural variant	ID=VAR_077197;Note=In CDG1K%3B decreased function in protein glycosylation as shown by rescue assays in an ALG1-deficient yeast strain. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26931382;Dbxref=PMID:26931382
ALG1	Q9BT22	320	357	325	325	Natural variant	ID=VAR_038426;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852920,PMID:15489334
ALG1	Q9BT22	320	357	342	342	Natural variant	ID=VAR_023366;Note=In CDG1K%3B decreased function in protein glycosylation as shown by rescue assays in an ALG1-deficient yeast strain. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14973782;Dbxref=dbSNP:rs267606651,PMID:14973782
ALG1	Q9BT22	320	357	353	353	Natural variant	ID=VAR_077198;Note=In CDG1K%3B decreased function in protein glycosylation as shown by rescue assays in an ALG1-deficient yeast strain. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26931382;Dbxref=PMID:26931382
ALG11	Q2TAA5	15	91	1	492	Chain	ID=PRO_0000295616;Note=GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1%2C2-mannosyltransferase
ALG11	Q2TAA5	15	91	20	40	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ALG11	Q2TAA5	15	91	86	86	Natural variant	ID=VAR_064908;Note=In CDG1P%3B does not affect subcellular localization%3B results in the accumulation of under-glycosylated proteins. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20080937;Dbxref=dbSNP:rs267606652,PMID:20080937
ALG11	Q2TAA5	15	91	86	86	Mutagenesis	Note=Does not affect function. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20080937;Dbxref=PMID:20080937
ALG11	Q2TAA5	15	91	86	86	Mutagenesis	Note=Loss of function. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20080937;Dbxref=PMID:20080937
AMBP	P02760	284	342	206	352	Chain	ID=PRO_0000017887;Note=Inter-alpha-trypsin inhibitor light chain
AMBP	P02760	284	342	284	344	Chain	ID=PRO_0000318926;Note=Trypstatin;Ontology_term=ECO:0000250;evidence=ECO:0000250
AMBP	P02760	284	342	287	337	Domain	Note=BPTI/Kunitz inhibitor 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00031
AMBP	P02760	284	342	297	298	Site	Note=Inhibitory (P1) (trypsin);Ontology_term=ECO:0000250;evidence=ECO:0000250
AMBP	P02760	284	342	287	337	Disulfide bond	.
AMBP	P02760	284	342	296	320	Disulfide bond	.
AMBP	P02760	284	342	312	333	Disulfide bond	.
AMBP	P02760	284	342	291	292	Sequence conflict	Note=IV->VI;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMBP	P02760	284	342	291	292	Sequence conflict	Note=IV->VI;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMBP	P02760	284	342	295	295	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
AMBP	P02760	284	342	284	288	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
AMBP	P02760	284	342	300	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
AMBP	P02760	284	342	307	310	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
AMBP	P02760	284	342	311	317	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
AMBP	P02760	284	342	319	321	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
AMBP	P02760	284	342	327	329	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
AMBP	P02760	284	342	330	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BIK
ADGB	Q8N7X0	1345	1404	1	1667	Chain	ID=PRO_0000232525;Note=Androglobin
ADAM23	O75077	311	335	287	832	Chain	ID=PRO_0000029119;Note=Disintegrin and metalloproteinase domain-containing protein 23
ADAM23	O75077	522	552	287	832	Chain	ID=PRO_0000029119;Note=Disintegrin and metalloproteinase domain-containing protein 23
ADAM23	O75077	311	335	287	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM23	O75077	522	552	287	792	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM23	O75077	311	335	299	496	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276
ADAM23	O75077	522	552	502	588	Domain	Note=Disintegrin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00068
ADAM23	O75077	522	552	547	547	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
ADAM23	O75077	522	552	548	548	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
AGR2	O95994	131	159	21	175	Chain	ID=PRO_0000001037;Note=Anterior gradient protein 2 homolog
AGR2	O95994	131	159	127	132	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNS
AGR2	O95994	131	159	133	135	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNS
AGR2	O95994	131	159	146	150	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNS
AGR2	O95994	131	159	154	156	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNS
AGR2	O95994	131	159	157	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LNS
AKAP8	O43823	509	541	1	692	Chain	ID=PRO_0000075381;Note=A-kinase anchor protein 8
AKAP8	O43823	509	541	525	569	Region	Note=Involved in condensin complex recruitment;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11964380;Dbxref=PMID:11964380
AGO4	Q9HCK5	725	759	1	861	Chain	ID=PRO_0000194063;Note=Protein argonaute-4
AGO4	Q9HCK5	725	759	509	820	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03033
AKT1S1	Q96B36	126	152	1	256	Chain	ID=PRO_0000253446;Note=Proline-rich AKT1 substrate 1
AKT1S1	Q96B36	126	152	1	256	Chain	ID=PRO_0000253446;Note=Proline-rich AKT1 substrate 1
AKT1S1	Q96B36	126	152	1	256	Chain	ID=PRO_0000253446;Note=Proline-rich AKT1 substrate 1
AKT1S1	Q96B36	126	152	1	256	Chain	ID=PRO_0000253446;Note=Proline-rich AKT1 substrate 1
AKT1S1	Q96B36	126	152	1	130	Alternative sequence	ID=VSP_052182;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AKT1S1	Q96B36	126	152	1	130	Alternative sequence	ID=VSP_052182;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AKT1S1	Q96B36	126	152	1	130	Alternative sequence	ID=VSP_052182;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AKT1S1	Q96B36	126	152	1	130	Alternative sequence	ID=VSP_052182;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TDP1	Q9NUW8	295	350	1	608	Chain	ID=PRO_0000212486;Note=Tyrosyl-DNA phosphodiesterase 1
TDP1	Q9NUW8	295	350	1	608	Chain	ID=PRO_0000212486;Note=Tyrosyl-DNA phosphodiesterase 1
TDP1	Q9NUW8	295	350	304	304	Natural variant	ID=VAR_025821;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs34452707
TDP1	Q9NUW8	295	350	304	304	Natural variant	ID=VAR_025821;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs34452707
TDP1	Q9NUW8	295	350	295	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	295	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	319	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	319	328	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	333	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	333	335	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	336	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TDP1	Q9NUW8	295	350	336	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1JY1
TYROBP	O43914	20	31	1	21	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
TYROBP	O43914	31	76	22	113	Chain	ID=PRO_0000022603;Note=TYRO protein tyrosine kinase-binding protein
TYROBP	O43914	20	31	22	113	Chain	ID=PRO_0000022603;Note=TYRO protein tyrosine kinase-binding protein
TYROBP	O43914	31	76	22	40	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYROBP	O43914	20	31	22	40	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYROBP	O43914	31	76	41	61	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYROBP	O43914	31	76	62	113	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYROBP	O43914	31	76	54	54	Site	Note=Important for interaction with transmembrane receptors
TYROBP	O43914	31	76	35	35	Disulfide bond	Note=Interchain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20890284;Dbxref=PMID:20890284
TYROBP	O43914	20	31	20	30	Alternative sequence	ID=VSP_046066;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16344560;Dbxref=PMID:16344560
TYROBP	O43914	31	76	54	54	Mutagenesis	Note=Reduced interaction with KLRC2 and KIR2DS3. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20890284;Dbxref=PMID:20890284
TYROBP	O43914	31	76	40	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WOL
TTL	Q8NG68	202	291	1	377	Chain	ID=PRO_0000212434;Note=Tubulin--tyrosine ligase
TTL	Q8NG68	292	339	1	377	Chain	ID=PRO_0000212434;Note=Tubulin--tyrosine ligase
TTL	Q8NG68	202	291	3	370	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTL	Q8NG68	292	339	3	370	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTL	Q8NG68	202	291	245	245	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
ZRSR2	Q15696	133	146	1	482	Chain	ID=PRO_0000082001;Note=U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
UBE2D1	P51668	40	66	1	147	Chain	ID=PRO_0000082460;Note=Ubiquitin-conjugating enzyme E2 D1
UBE2D1	P51668	40	66	42	42	Mutagenesis	Note=Decrease in autoubiquitination. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22496338;Dbxref=PMID:22496338
UBE2D1	P51668	40	66	62	62	Mutagenesis	Note=Decrease in autoubiquitination. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22496338;Dbxref=PMID:22496338
UBE2D1	P51668	40	66	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AP4
UBE2D1	P51668	40	66	44	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPL
UBE2D1	P51668	40	66	49	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPL
UBE2D1	P51668	40	66	58	61	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPL
UBE2D1	P51668	40	66	66	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QPL
UBAC1	Q9BSL1	111	147	1	405	Chain	ID=PRO_0000250449;Note=Ubiquitin-associated domain-containing protein 1
UBTF	P17480	635	651	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	401	453	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	349	363	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	220	257	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	78	106	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	635	651	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	401	453	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	349	363	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	220	257	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	78	106	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	635	651	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	401	453	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	349	363	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	220	257	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	78	106	1	764	Chain	ID=PRO_0000048625;Note=Nucleolar transcription factor 1
UBTF	P17480	220	257	196	264	DNA binding	Note=HMG box 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	220	257	196	264	DNA binding	Note=HMG box 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	220	257	196	264	DNA binding	Note=HMG box 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	349	363	298	362	DNA binding	Note=HMG box 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	349	363	298	362	DNA binding	Note=HMG box 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	349	363	298	362	DNA binding	Note=HMG box 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	401	453	407	475	DNA binding	Note=HMG box 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	401	453	407	475	DNA binding	Note=HMG box 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	401	453	407	475	DNA binding	Note=HMG box 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267
UBTF	P17480	401	453	412	412	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
UBTF	P17480	401	453	412	412	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
UBTF	P17480	401	453	412	412	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
UBTF	P17480	401	453	433	433	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P25976
UBTF	P17480	401	453	433	433	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P25976
UBTF	P17480	401	453	433	433	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P25976
UBTF	P17480	401	453	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
UBTF	P17480	401	453	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
UBTF	P17480	401	453	435	435	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
UBTF	P17480	635	651	638	638	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
UBTF	P17480	635	651	638	638	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
UBTF	P17480	635	651	638	638	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
UBTF	P17480	220	257	221	257	Alternative sequence	ID=VSP_002193;Note=In isoform UBF2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1940801;Dbxref=PMID:15489334,PMID:1940801
UBTF	P17480	220	257	221	257	Alternative sequence	ID=VSP_002193;Note=In isoform UBF2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1940801;Dbxref=PMID:15489334,PMID:1940801
UBTF	P17480	220	257	221	257	Alternative sequence	ID=VSP_002193;Note=In isoform UBF2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:1940801;Dbxref=PMID:15489334,PMID:1940801
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	2	158	Chain	ID=PRO_0000082454;Note=SUMO-conjugating enzyme UBC9
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	25	25	Site	Note=Interaction with RANBP2
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	49	49	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25114211,ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	22	22	Mutagenesis	Note=Impairs binding to RANBP2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	25	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	27	27	Mutagenesis	Note=Impairs binding to RANBP2. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	42	42	Mutagenesis	Note=Slightly impairs binding to RANBP2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	48	48	Mutagenesis	Note=Slightly impairs binding to RANBP2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15608651;Dbxref=PMID:15608651
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	25	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PE6
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UBE2I	P63279	22	50	36	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F6E
UNC45A	Q9H3U1	579	626	1	944	Chain	ID=PRO_0000249888;Note=Protein unc-45 homolog A
UNC45A	Q9H3U1	579	626	1	722	Alternative sequence	ID=VSP_020584;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
UNG	P13051	113	145	1	313	Chain	ID=PRO_0000176173;Note=Uracil-DNA glycosylase
UNG	P13051	113	145	109	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCI
UNG	P13051	113	145	127	129	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCI
UNG	P13051	113	145	131	133	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCI
UNG	P13051	113	145	136	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCI
UNG	P13051	113	145	139	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EMH
UNG	P13051	113	145	143	145	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FCI
UPK1A	O00322	28	95	1	258	Chain	ID=PRO_0000219286;Note=Uroplakin-1a
UPK1A	O00322	95	120	1	258	Chain	ID=PRO_0000219286;Note=Uroplakin-1a
UPK1A	O00322	156	216	1	258	Chain	ID=PRO_0000219286;Note=Uroplakin-1a
UPK1A	O00322	28	95	15	35	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	28	95	36	59	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	28	95	60	86	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	28	95	87	91	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	28	95	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	95	120	92	112	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	95	120	113	230	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	156	216	113	230	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	156	216	170	170	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1A	O00322	28	95	33	33	Natural variant	ID=VAR_052332;Note=S->A;Dbxref=dbSNP:rs2267586
UPRT	Q96BW1	187	241	1	309	Chain	ID=PRO_0000254535;Note=Uracil phosphoribosyltransferase homolog
UPRT	Q96BW1	187	241	238	246	Region	Note=5-phospho-alpha-D-ribose 1-diphosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q26998
UPRT	Q96BW1	187	241	203	203	Binding site	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q26998
UPRT	Q96BW1	187	241	232	232	Binding site	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q26998
UPRT	Q96BW1	187	241	177	309	Alternative sequence	ID=VSP_021207;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
UQCC2	Q9BRT2	46	71	14	126	Chain	ID=PRO_0000089526;Note=Ubiquinol-cytochrome-c reductase complex assembly factor 2
TTC31	Q49AM3	154	182	1	519	Chain	ID=PRO_0000281149;Note=Tetratricopeptide repeat protein 31
TTC31	Q49AM3	154	182	147	197	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TTLL7	Q6ZT98	790	847	1	887	Chain	ID=PRO_0000212444;Note=Tubulin polyglutamylase TTLL7
TTLL7	Q6ZT98	500	529	1	887	Chain	ID=PRO_0000212444;Note=Tubulin polyglutamylase TTLL7
TTLL7	Q6ZT98	790	847	670	887	Alternative sequence	ID=VSP_015200;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
TTLL7	Q6ZT98	790	847	791	792	Alternative sequence	ID=VSP_015201;Note=In isoform 3. SS->YV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTLL7	Q6ZT98	790	847	793	887	Alternative sequence	ID=VSP_015202;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTLL7	Q6ZT98	500	529	490	500	Mutagenesis	Note=69%25 decreased polyglutamylase activity. RELNNPLKRMK->DELNNPLDDMD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25959773;Dbxref=PMID:25959773
TYSND1	Q2T9J0	432	494	1	566	Chain	ID=PRO_0000286124;Note=Peroxisomal leader peptide-processing protease
TYSND1	Q2T9J0	432	494	111	566	Chain	ID=PRO_0000286126;Note=Peroxisomal leader peptide-processing protease%2C 45 kDa form
TYSND1	Q2T9J0	432	494	319	531	Region	Note=Serine protease
TYSND1	Q2T9J0	432	494	481	481	Active site	Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250
TYSND1	Q2T9J0	432	494	399	566	Alternative sequence	ID=VSP_025001;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TYSND1	Q2T9J0	432	494	481	481	Mutagenesis	Note=Abrogates the self-cleaving activity of TYSND1. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22002062;Dbxref=PMID:22002062
TYW3	Q6IPR3	58	85	1	259	Chain	ID=PRO_0000281842;Note=tRNA wybutosine-synthesizing protein 3 homolog
TYW3	Q6IPR3	85	118	1	259	Chain	ID=PRO_0000281842;Note=tRNA wybutosine-synthesizing protein 3 homolog
TYW3	Q6IPR3	118	142	1	259	Chain	ID=PRO_0000281842;Note=tRNA wybutosine-synthesizing protein 3 homolog
TYW3	Q6IPR3	85	118	86	118	Alternative sequence	ID=VSP_044477;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TYW3	Q6IPR3	118	142	86	118	Alternative sequence	ID=VSP_044477;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TYW3	Q6IPR3	85	118	110	110	Natural variant	ID=VAR_031292;Note=R->Q;Dbxref=dbSNP:rs11538281
TYW3	Q6IPR3	118	142	121	121	Natural variant	ID=VAR_031293;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1133891,PMID:14702039
TYMS	P04818	151	185	2	313	Chain	ID=PRO_0000140901;Note=Thymidylate synthase
TYMS	P04818	244	268	2	313	Chain	ID=PRO_0000140901;Note=Thymidylate synthase
TYMS	P04818	151	185	175	176	Nucleotide binding	Note=dUMP%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A884
TYMS	P04818	244	268	256	258	Nucleotide binding	Note=dUMP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A884
TYMS	P04818	151	185	69	151	Alternative sequence	ID=VSP_047745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12706868;Dbxref=PMID:12706868
TYMS	P04818	151	185	152	185	Alternative sequence	ID=VSP_047746;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12706868;Dbxref=PMID:12706868
TYMS	P04818	151	185	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	151	185	156	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHI
TYMS	P04818	151	185	160	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	151	185	178	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	151	185	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	244	268	244	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	244	268	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	244	268	262	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
UBE2G2	P60604	81	128	2	165	Chain	ID=PRO_0000082483;Note=Ubiquitin-conjugating enzyme E2 G2
UBE2G2	P60604	81	128	89	89	Active site	Note=Glycyl thioester intermediate
UBE2G2	P60604	81	128	101	107	Sequence conflict	Note=MGYESSA->HGLREQP;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2G2	P60604	81	128	86	88	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8K
UBE2G2	P60604	81	128	91	93	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8K
UBE2G2	P60604	81	128	105	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CYX
UBE2G2	P60604	81	128	116	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8K
UPP2	O95045	60	113	1	317	Chain	ID=PRO_0000063193;Note=Uridine phosphorylase 2
UPP2	O95045	60	113	95	102	Disulfide bond	Note=Redox-active;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21855639;Dbxref=PMID:21855639
UPP2	O95045	60	113	78	78	Natural variant	ID=VAR_034580;Note=M->L;Dbxref=dbSNP:rs7561584
UPP2	O95045	60	113	61	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0F
UPP2	O95045	60	113	68	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0F
UPP2	O95045	60	113	88	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0E
UPP2	O95045	60	113	94	97	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0E
UPP2	O95045	60	113	98	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0F
UPP2	O95045	60	113	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0F
UPP2	O95045	60	113	109	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3P0F
USH1C	Q9Y6N9	273	292	1	552	Chain	ID=PRO_0000065727;Note=Harmonin
USH1C	Q9Y6N9	35	82	1	552	Chain	ID=PRO_0000065727;Note=Harmonin
USH1C	Q9Y6N9	273	292	211	293	Domain	Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143
USH1C	Q9Y6N9	35	82	1	86	Region	Note=N-terminal domain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20142502;Dbxref=PMID:20142502
USH1C	Q9Y6N9	273	292	194	552	Region	Note=Mediates interaction with MYO7B;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26812017,ECO:0000269|PubMed:26812018;Dbxref=PMID:26812017,PMID:26812018
USH1C	Q9Y6N9	273	292	274	292	Alternative sequence	ID=VSP_007422;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USH1C	Q9Y6N9	273	292	280	280	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
USH1C	Q9Y6N9	273	292	280	280	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
USH1C	Q9Y6N9	35	82	20	36	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	39	46	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	53	56	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	57	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	63	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	68	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	35	82	71	77	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3K1R
USH1C	Q9Y6N9	273	292	273	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5N
USH1C	Q9Y6N9	273	292	282	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5N
USH1C	Q9Y6N9	273	292	292	294	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X5N
UTP6	Q9NYH9	375	435	1	597	Chain	ID=PRO_0000205754;Note=U3 small nucleolar RNA-associated protein 6 homolog
UXT	Q9UBK9	83	118	1	157	Chain	ID=PRO_0000065751;Note=Protein UXT
ATP6V0E1	O15342	35	50	1	81	Chain	ID=PRO_0000071740;Note=V-type proton ATPase subunit e 1
ATP6V0E1	O15342	35	50	36	56	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VAMP4	O75379	38	54	1	141	Chain	ID=PRO_0000206731;Note=Vesicle-associated membrane protein 4
VAMP4	O75379	38	54	1	115	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VAMP4	O75379	38	54	52	112	Domain	Note=v-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00290
VAMP4	O75379	38	54	39	39	Alternative sequence	ID=VSP_006326;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VAT1	Q99536	255	285	2	393	Chain	ID=PRO_0000160918;Note=Synaptic vesicle membrane protein VAT-1 homolog
VAT1	Q99536	198	255	2	393	Chain	ID=PRO_0000160918;Note=Synaptic vesicle membrane protein VAT-1 homolog
VAT1	Q99536	198	255	207	208	Sequence conflict	Note=QL->HV;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP6V1E1	P36543	92	122	2	226	Chain	ID=PRO_0000117295;Note=V-type proton ATPase subunit E 1
ATP6V1E1	P36543	92	122	93	122	Alternative sequence	ID=VSP_044589;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VDR	P11473	302	341	1	427	Chain	ID=PRO_0000053542;Note=Vitamin D3 receptor
VDR	P11473	302	341	1	427	Chain	ID=PRO_0000053542;Note=Vitamin D3 receptor
VDR	P11473	302	341	1	427	Chain	ID=PRO_0000053542;Note=Vitamin D3 receptor
VDR	P11473	302	341	127	423	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
VDR	P11473	302	341	127	423	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
VDR	P11473	302	341	127	423	Domain	Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189
VDR	P11473	302	341	305	305	Binding site	Note=Vitamin D3
VDR	P11473	302	341	305	305	Binding site	Note=Vitamin D3
VDR	P11473	302	341	305	305	Binding site	Note=Vitamin D3
VDR	P11473	302	341	152	427	Natural variant	ID=VAR_079325;Note=In VDDR2A%3B loss of calcitriol receptor activity%3B loss of affinity for calcitriol%3B no effect on ligand-independent localization to the nucleus. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28698609,ECO:0000269|PubMed:8392085;Dbxref=dbSNP:rs121909795,PMID:28698609,PMID:8392085
VDR	P11473	302	341	152	427	Natural variant	ID=VAR_079325;Note=In VDDR2A%3B loss of calcitriol receptor activity%3B loss of affinity for calcitriol%3B no effect on ligand-independent localization to the nucleus. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28698609,ECO:0000269|PubMed:8392085;Dbxref=dbSNP:rs121909795,PMID:28698609,PMID:8392085
VDR	P11473	302	341	152	427	Natural variant	ID=VAR_079325;Note=In VDDR2A%3B loss of calcitriol receptor activity%3B loss of affinity for calcitriol%3B no effect on ligand-independent localization to the nucleus. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28698609,ECO:0000269|PubMed:8392085;Dbxref=dbSNP:rs121909795,PMID:28698609,PMID:8392085
VDR	P11473	302	341	305	305	Natural variant	ID=VAR_004665;Note=In VDDR2A%3B loss of calcitriol receptor activity%3B no effect on interaction with RXRA%3B changed interaction with NCOR1%3B loss of interaction with NCOA1%3B no effect on sequence-specific DNA-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28698609,ECO:0000269|PubMed:9005998;Dbxref=dbSNP:rs121909798,PMID:28698609,PMID:9005998
VDR	P11473	302	341	305	305	Natural variant	ID=VAR_004665;Note=In VDDR2A%3B loss of calcitriol receptor activity%3B no effect on interaction with RXRA%3B changed interaction with NCOR1%3B loss of interaction with NCOA1%3B no effect on sequence-specific DNA-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28698609,ECO:0000269|PubMed:9005998;Dbxref=dbSNP:rs121909798,PMID:28698609,PMID:9005998
VDR	P11473	302	341	305	305	Natural variant	ID=VAR_004665;Note=In VDDR2A%3B loss of calcitriol receptor activity%3B no effect on interaction with RXRA%3B changed interaction with NCOR1%3B loss of interaction with NCOA1%3B no effect on sequence-specific DNA-binding. H->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28698609,ECO:0000269|PubMed:9005998;Dbxref=dbSNP:rs121909798,PMID:28698609,PMID:9005998
VDR	P11473	302	341	314	314	Natural variant	ID=VAR_004666;Note=In VDDR2A. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961271;Dbxref=dbSNP:rs121909799,PMID:8961271
VDR	P11473	302	341	314	314	Natural variant	ID=VAR_004666;Note=In VDDR2A. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961271;Dbxref=dbSNP:rs121909799,PMID:8961271
VDR	P11473	302	341	314	314	Natural variant	ID=VAR_004666;Note=In VDDR2A. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8961271;Dbxref=dbSNP:rs121909799,PMID:8961271
VDR	P11473	302	341	302	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	302	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	302	304	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	307	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	307	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	307	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	322	324	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HAR
VDR	P11473	302	341	322	324	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HAR
VDR	P11473	302	341	322	324	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HAR
VDR	P11473	302	341	327	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	327	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	327	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B0T
VDR	P11473	302	341	341	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AUQ
VDR	P11473	302	341	341	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AUQ
VDR	P11473	302	341	341	343	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AUQ
VEZF1	Q14119	325	379	1	521	Chain	ID=PRO_0000047435;Note=Vascular endothelial zinc finger 1
VEZF1	Q14119	325	379	340	354	Compositional bias	Note=Poly-Gln
VEZF1	Q14119	325	379	362	362	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
VEZF1	Q14119	325	379	350	354	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
VGLL3	A8MV65	134	312	1	326	Chain	ID=PRO_0000324661;Note=Transcription cofactor vestigial-like protein 3
VGLL3	A8MV65	134	312	221	248	Compositional bias	Note=His-rich;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYW5	A2RUC4	116	162	1	315	Chain	ID=PRO_0000309274;Note=tRNA wybutosine-synthesizing protein 5
TYW5	A2RUC4	116	162	102	267	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
TYW5	A2RUC4	116	162	160	160	Metal binding	Note=Iron%3B catalytic
TYW5	A2RUC4	116	162	162	162	Metal binding	Note=Iron%3B catalytic
TYW5	A2RUC4	116	162	1	163	Alternative sequence	ID=VSP_029106;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TYW5	A2RUC4	116	162	149	149	Mutagenesis	Note=Abolishes enzyme activity and ability to bind tRNA. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20972222;Dbxref=PMID:20972222
TYW5	A2RUC4	116	162	114	116	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL5
TYW5	A2RUC4	116	162	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL5
TYW5	A2RUC4	116	162	126	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL5
TYW5	A2RUC4	116	162	140	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL5
TYW5	A2RUC4	116	162	143	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL5
TYW5	A2RUC4	116	162	156	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AL5
UACA	Q9BZF9	1371	1393	1	1416	Chain	ID=PRO_0000231650;Note=Uveal autoantigen with coiled-coil domains and ankyrin repeats
UACA	Q9BZF9	1320	1371	1	1416	Chain	ID=PRO_0000231650;Note=Uveal autoantigen with coiled-coil domains and ankyrin repeats
UACA	Q9BZF9	333	344	1	1416	Chain	ID=PRO_0000231650;Note=Uveal autoantigen with coiled-coil domains and ankyrin repeats
UACA	Q9BZF9	333	344	286	374	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
UACA	Q9BZF9	1371	1393	438	1386	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
UACA	Q9BZF9	1320	1371	438	1386	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
UBE2V2	Q15819	55	97	2	145	Chain	ID=PRO_0000082602;Note=Ubiquitin-conjugating enzyme E2 variant 2
UBE2V2	Q15819	55	97	78	78	Natural variant	ID=VAR_052433;Note=P->Q;Dbxref=dbSNP:rs11557786
UBE2V2	Q15819	55	97	54	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRI
UBE2V2	Q15819	55	97	57	60	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2V2	Q15819	55	97	62	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2V2	Q15819	55	97	71	75	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2V2	Q15819	55	97	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBE2V2	Q15819	55	97	93	95	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ONL
UBFD1	O14562	188	210	1	309	Chain	ID=PRO_0000283075;Note=Ubiquitin domain-containing protein UBFD1
UBE2A	P49459	50	80	1	152	Chain	ID=PRO_0000082445;Note=Ubiquitin-conjugating enzyme E2 A
UBE2A	P49459	50	80	1	75	Alternative sequence	ID=VSP_043851;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2A	P49459	50	80	51	80	Alternative sequence	ID=VSP_043852;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBASH3A	P57075	184	222	1	661	Chain	ID=PRO_0000210994;Note=Ubiquitin-associated and SH3 domain-containing protein A
UBASH3A	P57075	423	464	1	661	Chain	ID=PRO_0000210994;Note=Ubiquitin-associated and SH3 domain-containing protein A
UBASH3A	P57075	423	464	395	661	Region	Note=Phosphatase-like
UBASH3A	P57075	184	222	185	223	Alternative sequence	ID=VSP_006703;Note=In isoform 2 and isoform 3. GTSVSRFWIFSQVPGHGPNLRLSNLTRASFVSHYILQKY->D;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11281453,ECO:0000303|PubMed:15107835,ECO:0000303|PubMed:15489334;Dbxref=PMID:11281453,PMID:15107835,PMID:15489334
UBASH3A	P57075	423	464	445	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WDI
UBASH3A	P57075	423	464	455	471	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WDI
UCHL3	P15374	18	61	1	230	Chain	ID=PRO_0000211061;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L3
UCHL3	P15374	142	158	1	230	Chain	ID=PRO_0000211061;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L3
UCHL3	P15374	142	158	152	159	Region	Note=Interaction with ubiquitin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15531586;Dbxref=PMID:15531586
UCHL3	P15374	18	61	33	33	Mutagenesis	Note=Decreased interaction with diubiquitin. No accumulation of free diubiquitin. Decreased levels of polyubiquitinated lysozyme. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19154770,ECO:0000269|PubMed:20380862;Dbxref=PMID:19154770,PMID:20380862
UCHL3	P15374	18	61	13	22	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UCHL3	P15374	18	61	29	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UCHL3	P15374	18	61	39	42	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UCHL3	P15374	18	61	49	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UCHL3	P15374	18	61	60	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UCHL3	P15374	142	158	142	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UCHL3	P15374	142	158	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XD3
UGT2A1	Q9Y4X1	288	332	21	527	Chain	ID=PRO_0000036023;Note=UDP-glucuronosyltransferase 2A1
UGT2A1	Q9Y4X1	288	332	21	490	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UGT2A1	Q9Y4X1	288	332	313	313	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
UGT2A1	Q9Y4X1	288	332	288	331	Alternative sequence	ID=VSP_039376;Note=In isoform 3%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:19858781;Dbxref=PMID:14702039,PMID:19858781
UGT2A1	Q9Y4X1	288	332	308	308	Natural variant	ID=VAR_024686;Note=G->R;Dbxref=dbSNP:rs4148301
UFM1	P61960	52	63	1	83	Chain	ID=PRO_0000042122;Note=Ubiquitin-fold modifier 1
UFM1	P61960	52	63	60	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IA7
UFM1	P61960	52	63	63	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IA7
UFSP2	Q9NUQ7	277	332	1	469	Chain	ID=PRO_0000280362;Note=Ufm1-specific protease 2
UFSP2	Q9NUQ7	277	332	302	302	Active site	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
UFSP2	Q9NUQ7	277	332	290	290	Natural variant	ID=VAR_074673;Note=In BFHD%3B loss of protease activity toward the C-terminal of UFM1. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26428751;Dbxref=dbSNP:rs796052130,PMID:26428751
UFSP2	Q9NUQ7	277	332	302	302	Mutagenesis	Note=Catalytically inactive. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
UGGT2	Q9NYU1	1428	1467	28	1516	Chain	ID=PRO_0000012274;Note=UDP-glucose:glycoprotein glucosyltransferase 2
UGGT2	Q9NYU1	1275	1336	28	1516	Chain	ID=PRO_0000012274;Note=UDP-glucose:glycoprotein glucosyltransferase 2
UGGT2	Q9NYU1	1215	1246	28	1516	Chain	ID=PRO_0000012274;Note=UDP-glucose:glycoprotein glucosyltransferase 2
UGGT2	Q9NYU1	1076	1129	28	1516	Chain	ID=PRO_0000012274;Note=UDP-glucose:glycoprotein glucosyltransferase 2
UGGT2	Q9NYU1	834	878	28	1516	Chain	ID=PRO_0000012274;Note=UDP-glucose:glycoprotein glucosyltransferase 2
UGGT2	Q9NYU1	1428	1467	1220	1516	Region	Note=Glucosyltransferase
UGGT2	Q9NYU1	1275	1336	1220	1516	Region	Note=Glucosyltransferase
UGGT2	Q9NYU1	1215	1246	1220	1516	Region	Note=Glucosyltransferase
UGGT2	Q9NYU1	1275	1336	1289	1289	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
UGGT2	Q9NYU1	1428	1467	279	1516	Alternative sequence	ID=VSP_056320;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UGGT2	Q9NYU1	1275	1336	279	1516	Alternative sequence	ID=VSP_056320;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UGGT2	Q9NYU1	1215	1246	279	1516	Alternative sequence	ID=VSP_056320;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UGGT2	Q9NYU1	1076	1129	279	1516	Alternative sequence	ID=VSP_056320;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UGGT2	Q9NYU1	834	878	279	1516	Alternative sequence	ID=VSP_056320;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UGGT2	Q9NYU1	834	878	865	865	Natural variant	ID=VAR_061196;Note=K->R;Dbxref=dbSNP:rs35060832
UGGT2	Q9NYU1	1275	1336	1285	1285	Natural variant	ID=VAR_061197;Note=Y->F;Dbxref=dbSNP:rs35123499
UNC13D	Q70J99	851	875	1	1090	Chain	ID=PRO_0000188581;Note=Protein unc-13 homolog D
UNC13D	Q70J99	697	766	1	1090	Chain	ID=PRO_0000188581;Note=Protein unc-13 homolog D
UNC13D	Q70J99	286	317	1	1090	Chain	ID=PRO_0000188581;Note=Protein unc-13 homolog D
UNC13D	Q70J99	87	107	1	1090	Chain	ID=PRO_0000188581;Note=Protein unc-13 homolog D
UNC13D	Q70J99	39	51	1	1090	Chain	ID=PRO_0000188581;Note=Protein unc-13 homolog D
UNC13D	Q70J99	87	107	98	221	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
UNC13D	Q70J99	851	875	788	895	Domain	Note=MHD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00588
UNC13D	Q70J99	286	317	240	543	Region	Note=Interaction with RAB27A
UNC13D	Q70J99	286	317	286	286	Alternative sequence	ID=VSP_011385;Note=In isoform 2. R->RVGRVLGQWPCPALAAVCWVAGLAAPSVRPCLLTEASLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
UNC13D	Q70J99	851	875	326	1090	Alternative sequence	ID=VSP_011387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
UNC13D	Q70J99	697	766	326	1090	Alternative sequence	ID=VSP_011387;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971
UNC13D	Q70J99	851	875	858	858	Natural variant	ID=VAR_029771;Note=H->Q;Dbxref=dbSNP:rs17496835
UNC13D	Q70J99	851	875	867	867	Natural variant	ID=VAR_029772;Note=K->E;Dbxref=dbSNP:rs1135688
UNC5D	Q6UXZ4	250	306	33	953	Chain	ID=PRO_0000036079;Note=Netrin receptor UNC5D
UNC5D	Q6UXZ4	361	372	33	953	Chain	ID=PRO_0000036079;Note=Netrin receptor UNC5D
UNC5D	Q6UXZ4	250	306	33	379	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5D	Q6UXZ4	361	372	33	379	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5D	Q6UXZ4	250	306	252	306	Domain	Note=TSP type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
UNC5D	Q6UXZ4	250	306	264	301	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
UNC5D	Q6UXZ4	250	306	268	305	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
UNC5D	Q6UXZ4	250	306	279	291	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
UNC80	Q8N2C7	2363	2419	1	3258	Chain	ID=PRO_0000089348;Note=Protein unc-80 homolog
UNC80	Q8N2C7	2644	2686	1	3258	Chain	ID=PRO_0000089348;Note=Protein unc-80 homolog
UNC80	Q8N2C7	3020	3038	1	3258	Chain	ID=PRO_0000089348;Note=Protein unc-80 homolog
UNC80	Q8N2C7	2363	2419	2398	2418	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC80	Q8N2C7	2363	2419	1	2554	Alternative sequence	ID=VSP_036741;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UNC80	Q8N2C7	2363	2419	321	3258	Alternative sequence	ID=VSP_036743;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
UNC80	Q8N2C7	2644	2686	321	3258	Alternative sequence	ID=VSP_036743;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
UNC80	Q8N2C7	3020	3038	321	3258	Alternative sequence	ID=VSP_036743;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
UNC80	Q8N2C7	2644	2686	2604	3258	Alternative sequence	ID=VSP_031528;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
UNC80	Q8N2C7	3020	3038	2604	3258	Alternative sequence	ID=VSP_031528;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11347906;Dbxref=PMID:11347906
UNC80	Q8N2C7	3020	3038	3020	3038	Alternative sequence	ID=VSP_036744;Note=In isoform 5 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UNC80	Q8N2C7	3020	3038	3020	3020	Alternative sequence	ID=VSP_036745;Note=In isoform 4 and isoform 6. S->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UNC80	Q8N2C7	3020	3038	3021	3258	Alternative sequence	ID=VSP_036746;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UNK	Q9C0B0	35	104	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
UNK	Q9C0B0	435	457	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
UNK	Q9C0B0	549	612	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
UNK	Q9C0B0	35	104	84	113	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
UNK	Q9C0B0	35	104	70	73	Compositional bias	Note=Poly-Arg
TTI2	Q6NXR4	372	419	1	508	Chain	ID=PRO_0000279414;Note=TELO2-interacting protein 2
TTI2	Q6NXR4	278	309	1	508	Chain	ID=PRO_0000279414;Note=TELO2-interacting protein 2
TTI2	Q6NXR4	372	419	1	508	Chain	ID=PRO_0000279414;Note=TELO2-interacting protein 2
TTI2	Q6NXR4	278	309	1	508	Chain	ID=PRO_0000279414;Note=TELO2-interacting protein 2
TTYH3	Q9C0H2	209	240	1	523	Chain	ID=PRO_0000312251;Note=Protein tweety homolog 3
TTYH3	Q9C0H2	309	340	1	523	Chain	ID=PRO_0000312251;Note=Protein tweety homolog 3
TTYH3	Q9C0H2	340	371	1	523	Chain	ID=PRO_0000312251;Note=Protein tweety homolog 3
TTYH3	Q9C0H2	417	474	1	523	Chain	ID=PRO_0000312251;Note=Protein tweety homolog 3
TTYH3	Q9C0H2	209	240	108	211	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	209	240	212	232	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	209	240	233	236	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	209	240	237	257	Transmembrane	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	309	340	258	386	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	340	371	258	386	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	417	474	408	523	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTYH3	Q9C0H2	340	371	351	351	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15010458;Dbxref=PMID:15010458
TTYH3	Q9C0H2	209	240	210	241	Alternative sequence	ID=VSP_029770;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12693554;Dbxref=PMID:12693554
TTYH3	Q9C0H2	340	371	353	353	Mutagenesis	Note=Abolishes N-glycosylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15010458;Dbxref=PMID:15010458
TTYH3	Q9C0H2	340	371	367	367	Mutagenesis	Note=Induces a stronger permeability to cations. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15010458;Dbxref=PMID:15010458
TTYH3	Q9C0H2	340	371	370	370	Mutagenesis	Note=Shows a different ion selectivity. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15010458;Dbxref=PMID:15010458
TTYH3	Q9C0H2	340	371	346	346	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2Q2	Q8WVN8	94	129	1	375	Chain	ID=PRO_0000223879;Note=Ubiquitin-conjugating enzyme E2 Q2
UBE2Q2	Q8WVN8	149	196	1	375	Chain	ID=PRO_0000223879;Note=Ubiquitin-conjugating enzyme E2 Q2
UBE2Q2	Q8WVN8	311	343	1	375	Chain	ID=PRO_0000223879;Note=Ubiquitin-conjugating enzyme E2 Q2
UBE2Q2	Q8WVN8	149	196	134	178	Compositional bias	Note=Glu-rich
UBE2Q2	Q8WVN8	94	129	95	129	Alternative sequence	ID=VSP_055681;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBE2Q2	Q8WVN8	311	343	296	314	Alternative sequence	ID=VSP_017298;Note=In isoform 2. YVLGGGALCMELLTKQGWS->LVHPSKGRWLNMLTVVCLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE2Q2	Q8WVN8	311	343	315	375	Alternative sequence	ID=VSP_017299;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE2Q2	Q8WVN8	149	196	161	161	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2Q2	Q8WVN8	311	343	310	312	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUO
UBE2Q2	Q8WVN8	311	343	319	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ZUO
UBE2R2	Q712K3	121	165	1	238	Chain	ID=PRO_0000280513;Note=Ubiquitin-conjugating enzyme E2 R2
UBE2R2	Q712K3	121	165	127	127	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBALD1	Q8TB05	40	61	1	177	Chain	ID=PRO_0000236079;Note=UBA-like domain-containing protein 1
UBALD1	Q8TB05	40	61	1	61	Alternative sequence	ID=VSP_018573;Note=In isoform 2. MSVNMDELKHQVMINQFVLTAGCAADQAKQLLQAAHWQFETALSAFFQETNIPYSHHHHQM->MKLLTLQPPGMLWLMERGGLGKPRGPRHRGLLRVRLGRFISRLLLWEPLGGGQAWGSGEGTQSLPRMGQPRISPWEAVGAPPGRGAHPISPLFPSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
UBE2E3	Q969T4	65	81	2	207	Chain	ID=PRO_0000082474;Note=Ubiquitin-conjugating enzyme E2 E3
UBE2E3	Q969T4	65	81	2	207	Chain	ID=PRO_0000082474;Note=Ubiquitin-conjugating enzyme E2 E3
UBE2E3	Q969T4	65	81	2	207	Chain	ID=PRO_0000082474;Note=Ubiquitin-conjugating enzyme E2 E3
UBE2E3	Q969T4	65	81	2	207	Chain	ID=PRO_0000082474;Note=Ubiquitin-conjugating enzyme E2 E3
UBE2E3	Q969T4	65	81	65	65	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2E3	Q969T4	65	81	65	65	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2E3	Q969T4	65	81	65	65	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2E3	Q969T4	65	81	65	65	Sequence conflict	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP47	Q96K76	13	33	1	1375	Chain	ID=PRO_0000080676;Note=Ubiquitin carboxyl-terminal hydrolase 47
USP47	Q96K76	293	343	1	1375	Chain	ID=PRO_0000080676;Note=Ubiquitin carboxyl-terminal hydrolase 47
USP47	Q96K76	482	526	1	1375	Chain	ID=PRO_0000080676;Note=Ubiquitin carboxyl-terminal hydrolase 47
USP47	Q96K76	1258	1274	1	1375	Chain	ID=PRO_0000080676;Note=Ubiquitin carboxyl-terminal hydrolase 47
USP47	Q96K76	293	343	188	564	Domain	Note=USP
USP47	Q96K76	482	526	188	564	Domain	Note=USP
USP47	Q96K76	482	526	503	503	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10092,ECO:0000255|PROSITE-ProRule:PRU10093
USP47	Q96K76	13	33	1	1218	Alternative sequence	ID=VSP_014414;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP47	Q96K76	293	343	1	1218	Alternative sequence	ID=VSP_014414;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP47	Q96K76	482	526	1	1218	Alternative sequence	ID=VSP_014414;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP47	Q96K76	13	33	14	101	Alternative sequence	ID=VSP_014415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP47	Q96K76	13	33	14	33	Alternative sequence	ID=VSP_055650;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP47	Q96K76	293	343	340	340	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP47	Q96K76	482	526	494	494	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP47	Q96K76	482	526	494	494	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP47	Q96K76	482	526	494	494	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP47	Q96K76	482	526	520	520	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP36	Q9P275	1007	1041	1	1123	Chain	ID=PRO_0000080666;Note=Ubiquitin carboxyl-terminal hydrolase 36
USP36	Q9P275	739	936	1	1123	Chain	ID=PRO_0000080666;Note=Ubiquitin carboxyl-terminal hydrolase 36
USP36	Q9P275	158	195	1	1123	Chain	ID=PRO_0000080666;Note=Ubiquitin carboxyl-terminal hydrolase 36
USP36	Q9P275	1007	1041	1	1123	Chain	ID=PRO_0000080666;Note=Ubiquitin carboxyl-terminal hydrolase 36
USP36	Q9P275	739	936	1	1123	Chain	ID=PRO_0000080666;Note=Ubiquitin carboxyl-terminal hydrolase 36
USP36	Q9P275	158	195	1	1123	Chain	ID=PRO_0000080666;Note=Ubiquitin carboxyl-terminal hydrolase 36
USP36	Q9P275	158	195	122	423	Domain	Note=USP
USP36	Q9P275	158	195	122	423	Domain	Note=USP
USP36	Q9P275	739	936	742	742	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
USP36	Q9P275	739	936	742	742	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
USP36	Q9P275	739	936	775	775	Natural variant	ID=VAR_037279;Note=R->Q;Dbxref=dbSNP:rs9889908
USP36	Q9P275	739	936	775	775	Natural variant	ID=VAR_037279;Note=R->Q;Dbxref=dbSNP:rs9889908
USP36	Q9P275	739	936	806	806	Natural variant	ID=VAR_037280;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3088040,PMID:10819331,PMID:14702039,PMID:15489334
USP36	Q9P275	739	936	806	806	Natural variant	ID=VAR_037280;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3088040,PMID:10819331,PMID:14702039,PMID:15489334
USP36	Q9P275	739	936	814	814	Natural variant	ID=VAR_037281;Note=K->N;Dbxref=dbSNP:rs3744797
USP36	Q9P275	739	936	814	814	Natural variant	ID=VAR_037281;Note=K->N;Dbxref=dbSNP:rs3744797
USP36	Q9P275	739	936	828	828	Natural variant	ID=VAR_037282;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1057040,PMID:10819331,PMID:14702039
USP36	Q9P275	739	936	828	828	Natural variant	ID=VAR_037282;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1057040,PMID:10819331,PMID:14702039
USP36	Q9P275	739	936	887	887	Natural variant	ID=VAR_058034;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs61760231,PMID:15489334
USP36	Q9P275	739	936	887	887	Natural variant	ID=VAR_058034;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs61760231,PMID:15489334
USP3	Q9Y6I4	51	94	1	520	Chain	ID=PRO_0000080619;Note=Ubiquitin carboxyl-terminal hydrolase 3
USP3	Q9Y6I4	95	122	1	520	Chain	ID=PRO_0000080619;Note=Ubiquitin carboxyl-terminal hydrolase 3
USP3	Q9Y6I4	178	215	1	520	Chain	ID=PRO_0000080619;Note=Ubiquitin carboxyl-terminal hydrolase 3
USP3	Q9Y6I4	254	302	1	520	Chain	ID=PRO_0000080619;Note=Ubiquitin carboxyl-terminal hydrolase 3
USP3	Q9Y6I4	178	215	159	511	Domain	Note=USP
USP3	Q9Y6I4	254	302	159	511	Domain	Note=USP
USP3	Q9Y6I4	51	94	27	104	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
USP3	Q9Y6I4	95	122	27	104	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
USP3	Q9Y6I4	51	94	51	95	Alternative sequence	ID=VSP_044712;Note=In isoform 2. RYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYC->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP3	Q9Y6I4	95	122	51	95	Alternative sequence	ID=VSP_044712;Note=In isoform 2. RYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYC->S;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP3	Q9Y6I4	51	94	56	56	Mutagenesis	Note=Does not reduce monoubiquitinated H2A and H2B stability. Interaction with monoubiquitinated H2A is strongly inhibited. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17980597;Dbxref=PMID:17980597
USP53	Q70EK8	225	274	1	1073	Chain	ID=PRO_0000080681;Note=Inactive ubiquitin carboxyl-terminal hydrolase 53
USP53	Q70EK8	274	324	1	1073	Chain	ID=PRO_0000080681;Note=Inactive ubiquitin carboxyl-terminal hydrolase 53
USP53	Q70EK8	378	429	1	1073	Chain	ID=PRO_0000080681;Note=Inactive ubiquitin carboxyl-terminal hydrolase 53
USP53	Q70EK8	225	274	1	1073	Chain	ID=PRO_0000080681;Note=Inactive ubiquitin carboxyl-terminal hydrolase 53
USP53	Q70EK8	274	324	1	1073	Chain	ID=PRO_0000080681;Note=Inactive ubiquitin carboxyl-terminal hydrolase 53
USP53	Q70EK8	378	429	1	1073	Chain	ID=PRO_0000080681;Note=Inactive ubiquitin carboxyl-terminal hydrolase 53
USP53	Q70EK8	225	274	30	351	Domain	Note=USP
USP53	Q70EK8	274	324	30	351	Domain	Note=USP
USP53	Q70EK8	225	274	30	351	Domain	Note=USP
USP53	Q70EK8	274	324	30	351	Domain	Note=USP
USP53	Q70EK8	274	324	276	276	Sequence conflict	Note=F->FF;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP53	Q70EK8	274	324	276	276	Sequence conflict	Note=F->FF;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBR2	Q8IWV8	139	177	2	1755	Chain	ID=PRO_0000056140;Note=E3 ubiquitin-protein ligase UBR2
UBR2	Q8IWV8	328	364	2	1755	Chain	ID=PRO_0000056140;Note=E3 ubiquitin-protein ligase UBR2
UBR2	Q8IWV8	699	740	2	1755	Chain	ID=PRO_0000056140;Note=E3 ubiquitin-protein ligase UBR2
UBR2	Q8IWV8	1573	1591	2	1755	Chain	ID=PRO_0000056140;Note=E3 ubiquitin-protein ligase UBR2
UBR2	Q8IWV8	1592	1617	2	1755	Chain	ID=PRO_0000056140;Note=E3 ubiquitin-protein ligase UBR2
UBR2	Q8IWV8	1618	1674	2	1755	Chain	ID=PRO_0000056140;Note=E3 ubiquitin-protein ligase UBR2
UBR2	Q8IWV8	139	177	97	168	Zinc finger	Note=UBR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00508
UBR2	Q8IWV8	139	177	1	496	Alternative sequence	ID=VSP_015166;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR2	Q8IWV8	328	364	1	496	Alternative sequence	ID=VSP_015166;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR2	Q8IWV8	699	740	440	1755	Alternative sequence	ID=VSP_015168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBR2	Q8IWV8	1573	1591	440	1755	Alternative sequence	ID=VSP_015168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBR2	Q8IWV8	1592	1617	440	1755	Alternative sequence	ID=VSP_015168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBR2	Q8IWV8	1618	1674	440	1755	Alternative sequence	ID=VSP_015168;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBR2	Q8IWV8	1573	1591	1072	1755	Alternative sequence	ID=VSP_015171;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR2	Q8IWV8	1592	1617	1072	1755	Alternative sequence	ID=VSP_015171;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR2	Q8IWV8	1618	1674	1072	1755	Alternative sequence	ID=VSP_015171;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR2	Q8IWV8	139	177	172	172	Natural variant	ID=VAR_052117;Note=E->D;Dbxref=dbSNP:rs6905054
UBR2	Q8IWV8	139	177	138	142	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDA
UBR2	Q8IWV8	139	177	154	156	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDA
UBR2	Q8IWV8	139	177	157	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDA
UBR2	Q8IWV8	139	177	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5TDA
UBR5	O95071	2614	2652	2	2799	Chain	ID=PRO_0000086931;Note=E3 ubiquitin-protein ligase UBR5
UBR5	O95071	2562	2614	2	2799	Chain	ID=PRO_0000086931;Note=E3 ubiquitin-protein ligase UBR5
UBR5	O95071	2058	2096	2	2799	Chain	ID=PRO_0000086931;Note=E3 ubiquitin-protein ligase UBR5
UBR5	O95071	1035	1067	2	2799	Chain	ID=PRO_0000086931;Note=E3 ubiquitin-protein ligase UBR5
UBR5	O95071	806	872	2	2799	Chain	ID=PRO_0000086931;Note=E3 ubiquitin-protein ligase UBR5
UBR5	O95071	405	442	2	2799	Chain	ID=PRO_0000086931;Note=E3 ubiquitin-protein ligase UBR5
UBR5	O95071	2614	2652	2462	2799	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
UBR5	O95071	2562	2614	2462	2799	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
UBR5	O95071	2058	2096	2036	2059	Compositional bias	Note=Pro-rich
UBR5	O95071	806	872	808	808	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:21924388;Dbxref=PMID:23186163,PMID:21924388
UBR5	O95071	2058	2096	2076	2076	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21924388;Dbxref=PMID:21924388
UCMA	Q8WVF2	41	73	27	138	Chain	ID=PRO_0000019549;Note=Unique cartilage matrix-associated protein
UCMA	Q8WVF2	41	73	28	64	Propeptide	ID=PRO_0000347063;Note=Ucma-N
UCMA	Q8WVF2	41	73	65	138	Chain	ID=PRO_0000347064;Note=Unique cartilage matrix-associated protein C-terminal fragment
AXL	P30530	195	222	26	894	Chain	ID=PRO_0000024481;Note=Tyrosine-protein kinase receptor UFO
AXL	P30530	544	570	26	894	Chain	ID=PRO_0000024481;Note=Tyrosine-protein kinase receptor UFO
AXL	P30530	195	222	26	451	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
AXL	P30530	544	570	473	894	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
AXL	P30530	195	222	139	222	Domain	Note=Ig-like C2-type 2
AXL	P30530	544	570	536	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AXL	P30530	544	570	542	550	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AXL	P30530	544	570	567	567	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AXL	P30530	195	222	198	198	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
AXL	P30530	195	222	160	205	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
AXL	P30530	195	222	201	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA0
AXL	P30530	195	222	212	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA0
AXL	P30530	195	222	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA0
AXL	P30530	544	570	536	544	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6B
AXL	P30530	544	570	546	556	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6B
AXL	P30530	544	570	558	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5U6B
UGP2	Q16851	357	438	1	508	Chain	ID=PRO_0000185752;Note=UTP--glucose-1-phosphate uridylyltransferase
UGP2	Q16851	357	438	396	396	Active site	Ontology_term=ECO:0000250;evidence=ECO:0000250
UGP2	Q16851	357	438	396	396	Binding site	Note=UTP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9M9P3
UGP2	Q16851	357	438	426	426	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
UGP2	Q16851	357	438	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
UGP2	Q16851	357	438	438	438	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
UGP2	Q16851	357	438	389	389	Mutagenesis	Note=No significant loss of activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8612650;Dbxref=PMID:8612650
UGP2	Q16851	357	438	391	391	Mutagenesis	Note=Loss of activity%3B possibly due to folding defect. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8612650;Dbxref=PMID:8612650
UGP2	Q16851	357	438	422	422	Mutagenesis	Note=No significant loss of activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8612650;Dbxref=PMID:8612650
UGP2	Q16851	357	438	353	359	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	360	362	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	363	369	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	372	378	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	383	386	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	389	391	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	398	405	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	409	412	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	415	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	423	426	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	429	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
UGP2	Q16851	357	438	434	436	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4R7P
NAE1	Q13564	412	443	2	534	Chain	ID=PRO_0000194951;Note=NEDD8-activating enzyme E1 regulatory subunit
NAE1	Q13564	383	412	2	534	Chain	ID=PRO_0000194951;Note=NEDD8-activating enzyme E1 regulatory subunit
NAE1	Q13564	83	107	2	534	Chain	ID=PRO_0000194951;Note=NEDD8-activating enzyme E1 regulatory subunit
NAE1	Q13564	83	107	1	89	Alternative sequence	ID=VSP_054258;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAE1	Q13564	83	107	101	101	Natural variant	ID=VAR_052435;Note=S->F;Dbxref=dbSNP:rs363212
NAE1	Q13564	83	107	85	94	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	83	107	104	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	383	412	377	385	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	383	412	387	389	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	383	412	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	383	412	398	402	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	383	412	404	406	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	412	443	409	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	383	412	409	415	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
NAE1	Q13564	412	443	423	439	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
ULK4	Q96C45	588	616	1	1275	Chain	ID=PRO_0000260154;Note=Serine/threonine-protein kinase ULK4
ULK4	Q96C45	552	588	1	1275	Chain	ID=PRO_0000260154;Note=Serine/threonine-protein kinase ULK4
ULK4	Q96C45	552	588	569	569	Natural variant	ID=VAR_029006;Note=K->R;Dbxref=dbSNP:rs3774372
ULK4	Q96C45	588	616	603	603	Natural variant	ID=VAR_029007;Note=L->S;Dbxref=dbSNP:rs17063572
ULK4	Q96C45	552	588	553	580	Sequence conflict	Note=AIVLLTELIRENFRNSKLKQCLLPTLGE->TTSSIGIGILNCLVQHSTPVPRQCLVYV;Ontology_term=ECO:0000305;evidence=ECO:0000305
UNC50	Q53HI1	180	214	1	259	Chain	ID=PRO_0000308961;Note=Protein unc-50 homolog
UNC50	Q53HI1	180	214	164	184	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC50	Q53HI1	180	214	185	187	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC50	Q53HI1	180	214	188	208	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC50	Q53HI1	180	214	209	222	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC13A	Q9UPW8	1519	1550	1	1703	Chain	ID=PRO_0000188573;Note=Protein unc-13 homolog A
UNC13A	Q9UPW8	174	186	1	1703	Chain	ID=PRO_0000188573;Note=Protein unc-13 homolog A
UNC13A	Q9UPW8	1519	1550	1532	1637	Domain	Note=C2 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
UNC5B	Q8IZJ1	355	366	27	945	Chain	ID=PRO_0000036071;Note=Netrin receptor UNC5B
UNC5B	Q8IZJ1	366	431	27	945	Chain	ID=PRO_0000036071;Note=Netrin receptor UNC5B
UNC5B	Q8IZJ1	775	830	27	945	Chain	ID=PRO_0000036071;Note=Netrin receptor UNC5B
UNC5B	Q8IZJ1	355	366	27	377	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5B	Q8IZJ1	366	431	27	377	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5B	Q8IZJ1	366	431	378	398	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5B	Q8IZJ1	366	431	399	945	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5B	Q8IZJ1	775	830	399	945	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5B	Q8IZJ1	775	830	689	838	Region	Note=UPA domain;Ontology_term=ECO:0000250;evidence=ECO:0000250
UNC5B	Q8IZJ1	366	431	412	413	Site	Note=Cleavage%3B by caspase-3;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12598906;Dbxref=PMID:12598906
UNC5B	Q8IZJ1	366	431	403	403	Lipidation	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08722
UNC5B	Q8IZJ1	355	366	356	367	Alternative sequence	ID=VSP_011698;Note=In isoform 2. NKKTLSDPNSHL->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12359238;Dbxref=PMID:12359238
UNC5B	Q8IZJ1	366	431	356	367	Alternative sequence	ID=VSP_011698;Note=In isoform 2. NKKTLSDPNSHL->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12359238;Dbxref=PMID:12359238
UNC5B	Q8IZJ1	366	431	412	412	Mutagenesis	Note=Abolishes cleavage by caspase-3 and subsequent induction of apoptosis. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12598906;Dbxref=PMID:12598906
UNC13C	Q8NB66	1498	1528	1	2214	Chain	ID=PRO_0000188578;Note=Protein unc-13 homolog C
TTC5	Q8N0Z6	232	281	1	440	Chain	ID=PRO_0000106381;Note=Tetratricopeptide repeat protein 5
TTC5	Q8N0Z6	232	281	224	253	Repeat	Note=TPR 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00339,ECO:0000269|PubMed:22362889;Dbxref=PMID:22362889
TTC5	Q8N0Z6	232	281	262	280	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XVS
TTC5	Q8N0Z6	232	281	281	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XVS
TTC7A	Q9ULT0	355	401	1	858	Chain	ID=PRO_0000106385;Note=Tetratricopeptide repeat protein 7A
TTC7A	Q9ULT0	429	464	1	858	Chain	ID=PRO_0000106385;Note=Tetratricopeptide repeat protein 7A
TTC7A	Q9ULT0	601	639	1	858	Chain	ID=PRO_0000106385;Note=Tetratricopeptide repeat protein 7A
TTC7A	Q9ULT0	672	717	1	858	Chain	ID=PRO_0000106385;Note=Tetratricopeptide repeat protein 7A
TTC7A	Q9ULT0	429	464	414	447	Repeat	Note=TPR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
TTC7A	Q9ULT0	672	717	678	678	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGB2
TTC7A	Q9ULT0	672	717	679	679	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BGB2
TTC7A	Q9ULT0	672	717	690	690	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TTC7A	Q9ULT0	672	717	693	693	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
TTC7A	Q9ULT0	355	401	147	858	Alternative sequence	ID=VSP_039348;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574461;Dbxref=PMID:10574461
TTC7A	Q9ULT0	429	464	147	858	Alternative sequence	ID=VSP_039348;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574461;Dbxref=PMID:10574461
TTC7A	Q9ULT0	601	639	147	858	Alternative sequence	ID=VSP_039348;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574461;Dbxref=PMID:10574461
TTC7A	Q9ULT0	672	717	147	858	Alternative sequence	ID=VSP_039348;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10574461;Dbxref=PMID:10574461
TTC7A	Q9ULT0	601	639	639	639	Alternative sequence	ID=VSP_057271;Note=In isoform 3. L->LGDFRSPEGFQTPQRNICNSEIYRG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTC7A	Q9ULT0	355	401	399	399	Natural variant	ID=VAR_075130;Note=In GIDID. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830146;Dbxref=PMID:23830146
TTC7A	Q9ULT0	601	639	606	606	Natural variant	ID=VAR_075134;Note=In GIDID%3B compound heterozygous with P-672. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830146;Dbxref=dbSNP:rs139010200,PMID:23830146
TTC7A	Q9ULT0	672	717	672	672	Natural variant	ID=VAR_075135;Note=In GIDID%3B compound heterozygous with R-606. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830146;Dbxref=dbSNP:rs149602485,PMID:23830146
TTC7A	Q9ULT0	672	717	678	678	Natural variant	ID=VAR_075136;Note=In GIDID. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830146;Dbxref=PMID:23830146
TTC7A	Q9ULT0	672	717	712	712	Natural variant	ID=VAR_075137;Note=In GIDID. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23830146;Dbxref=PMID:23830146
TTC7A	Q9ULT0	601	639	603	603	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
TTPAL	Q9BTX7	213	250	1	342	Chain	ID=PRO_0000210772;Note=Alpha-tocopherol transfer protein-like
TTPAL	Q9BTX7	213	250	1	342	Chain	ID=PRO_0000210772;Note=Alpha-tocopherol transfer protein-like
TTPAL	Q9BTX7	213	250	117	282	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
TTPAL	Q9BTX7	213	250	117	282	Domain	Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056
TXK	P42681	127	148	1	527	Chain	ID=PRO_0000088175;Note=Tyrosine-protein kinase TXK
TXK	P42681	127	148	82	142	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TXK	P42681	127	148	148	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DM0
UBE2L3	P68036	9	41	1	154	Chain	ID=PRO_0000082476;Note=Ubiquitin-conjugating enzyme E2 L3
UBE2L3	P68036	9	41	1	9	Alternative sequence	ID=VSP_047342;Note=In isoform 3. MAASRRLMK->MQVAAGTRGDTRLQEVALLPQLFDLLVLGQRRARLLRQVPSALAGKDLAQLQAGATLAGYRRAHGPE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBE2L3	P68036	9	41	10	41	Alternative sequence	ID=VSP_045152;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBE2L3	P68036	9	41	9	9	Mutagenesis	Note=Marked decrease in autoubiquitination. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22496338;Dbxref=PMID:22496338
UBE2L3	P68036	9	41	15	15	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2L3	P68036	9	41	23	23	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2L3	P68036	9	41	1	17	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q5E
UBE2L3	P68036	9	41	20	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q5E
UBE2L3	P68036	9	41	29	31	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1FBV
UBE2L3	P68036	9	41	34	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Q5E
UBLCP1	Q8WVY7	149	182	2	318	Chain	ID=PRO_0000242640;Note=Ubiquitin-like domain-containing CTD phosphatase 1
UBLCP1	Q8WVY7	195	228	2	318	Chain	ID=PRO_0000242640;Note=Ubiquitin-like domain-containing CTD phosphatase 1
UBLCP1	Q8WVY7	228	267	2	318	Chain	ID=PRO_0000242640;Note=Ubiquitin-like domain-containing CTD phosphatase 1
UBLCP1	Q8WVY7	149	182	133	294	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
UBLCP1	Q8WVY7	195	228	133	294	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
UBLCP1	Q8WVY7	228	267	133	294	Domain	Note=FCP1 homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00336
UBLCP1	Q8WVY7	149	182	133	294	Region	Note=Phosphatase
UBLCP1	Q8WVY7	195	228	133	294	Region	Note=Phosphatase
UBLCP1	Q8WVY7	228	267	133	294	Region	Note=Phosphatase
UBE3B	Q7Z3V4	788	834	1	1068	Chain	ID=PRO_0000281882;Note=Ubiquitin-protein ligase E3B
UBE3B	Q7Z3V4	788	834	1	1068	Chain	ID=PRO_0000281882;Note=Ubiquitin-protein ligase E3B
UBE3B	Q7Z3V4	788	834	702	1068	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
UBE3B	Q7Z3V4	788	834	702	1068	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
UBE3B	Q7Z3V4	788	834	245	1068	Alternative sequence	ID=VSP_024086;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3B	Q7Z3V4	788	834	245	1068	Alternative sequence	ID=VSP_024086;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3B	Q7Z3V4	788	834	709	1068	Alternative sequence	ID=VSP_024088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12837265,ECO:0000303|PubMed:17974005;Dbxref=PMID:12837265,PMID:17974005
UBE3B	Q7Z3V4	788	834	709	1068	Alternative sequence	ID=VSP_024088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12837265,ECO:0000303|PubMed:17974005;Dbxref=PMID:12837265,PMID:17974005
USP32	Q8NFA0	1516	1547	1	1601	Chain	ID=PRO_0000080663;Note=Ubiquitin carboxyl-terminal hydrolase 32
USP32	Q8NFA0	701	726	1	1601	Chain	ID=PRO_0000080663;Note=Ubiquitin carboxyl-terminal hydrolase 32
USP32	Q8NFA0	330	358	1	1601	Chain	ID=PRO_0000080663;Note=Ubiquitin carboxyl-terminal hydrolase 32
USP32	Q8NFA0	309	330	1	1601	Chain	ID=PRO_0000080663;Note=Ubiquitin carboxyl-terminal hydrolase 32
USP32	Q8NFA0	190	234	1	1601	Chain	ID=PRO_0000080663;Note=Ubiquitin carboxyl-terminal hydrolase 32
USP32	Q8NFA0	190	234	228	263	Domain	Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448
USP32	Q8NFA0	1516	1547	734	1567	Domain	Note=USP
USP32	Q8NFA0	1516	1547	1526	1526	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10092,ECO:0000255|PROSITE-ProRule:PRU10093
USP32	Q8NFA0	1516	1547	391	1604	Alternative sequence	ID=VSP_056308;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP32	Q8NFA0	701	726	391	1604	Alternative sequence	ID=VSP_056308;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP28	Q96RU2	768	800	1	1077	Chain	ID=PRO_0000080657;Note=Ubiquitin carboxyl-terminal hydrolase 28
USP28	Q96RU2	428	487	1	1077	Chain	ID=PRO_0000080657;Note=Ubiquitin carboxyl-terminal hydrolase 28
USP28	Q96RU2	396	427	1	1077	Chain	ID=PRO_0000080657;Note=Ubiquitin carboxyl-terminal hydrolase 28
USP28	Q96RU2	178	207	1	1077	Chain	ID=PRO_0000080657;Note=Ubiquitin carboxyl-terminal hydrolase 28
USP28	Q96RU2	428	487	162	650	Domain	Note=USP
USP28	Q96RU2	396	427	162	650	Domain	Note=USP
USP28	Q96RU2	178	207	162	650	Domain	Note=USP
USP28	Q96RU2	768	800	584	1077	Alternative sequence	ID=VSP_057360;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP28	Q96RU2	768	800	769	800	Alternative sequence	ID=VSP_015580;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10819331;Dbxref=PMID:10819331
USP6	P35125	253	275	1	1406	Chain	ID=PRO_0000080625;Note=Ubiquitin carboxyl-terminal hydrolase 6
USP6	P35125	253	275	1	1406	Chain	ID=PRO_0000080625;Note=Ubiquitin carboxyl-terminal hydrolase 6
USP6	P35125	253	275	100	292	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
USP6	P35125	253	275	100	292	Domain	Note=Rab-GAP TBC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00163
USP6	P35125	253	275	1	317	Alternative sequence	ID=VSP_010878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1565468;Dbxref=PMID:1565468
USP6	P35125	253	275	1	317	Alternative sequence	ID=VSP_010878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1565468;Dbxref=PMID:1565468
USP8	P40818	406	601	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	601	630	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	745	815	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	886	965	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	406	601	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	601	630	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	745	815	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	886	965	1	1118	Chain	ID=PRO_0000080627;Note=Ubiquitin carboxyl-terminal hydrolase 8
USP8	P40818	745	815	777	1109	Domain	Note=USP
USP8	P40818	886	965	777	1109	Domain	Note=USP
USP8	P40818	745	815	777	1109	Domain	Note=USP
USP8	P40818	886	965	777	1109	Domain	Note=USP
USP8	P40818	406	601	405	413	Motif	Note=SH3-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
USP8	P40818	406	601	405	413	Motif	Note=SH3-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
USP8	P40818	745	815	786	786	Active site	Note=Nucleophile;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10092,ECO:0000255|PROSITE-ProRule:PRU10093
USP8	P40818	745	815	786	786	Active site	Note=Nucleophile;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10092,ECO:0000255|PROSITE-ProRule:PRU10093
USP8	P40818	406	601	452	452	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
USP8	P40818	406	601	452	452	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
USP8	P40818	406	601	577	577	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
USP8	P40818	406	601	577	577	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
USP8	P40818	886	965	945	945	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80U87
USP8	P40818	886	965	945	945	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80U87
USP8	P40818	406	601	601	629	Alternative sequence	ID=VSP_054595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP8	P40818	601	630	601	629	Alternative sequence	ID=VSP_054595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP8	P40818	406	601	601	629	Alternative sequence	ID=VSP_054595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP8	P40818	601	630	601	629	Alternative sequence	ID=VSP_054595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP8	P40818	406	601	443	443	Natural variant	ID=VAR_017796;Note=D->G;Dbxref=dbSNP:rs3743044
USP8	P40818	406	601	443	443	Natural variant	ID=VAR_017796;Note=D->G;Dbxref=dbSNP:rs3743044
USP8	P40818	745	815	786	786	Mutagenesis	Note=Impairs deubiquitination activity and leads to endosome membrane accumulation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16520378;Dbxref=PMID:16520378
USP8	P40818	745	815	786	786	Mutagenesis	Note=Impairs deubiquitination activity and leads to endosome membrane accumulation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16520378;Dbxref=PMID:16520378
USP8	P40818	406	601	526	526	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP8	P40818	406	601	526	526	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP8	P40818	886	965	945	945	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP8	P40818	886	965	945	945	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP8	P40818	745	815	763	765	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	763	765	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	782	784	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	782	784	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	786	796	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	786	796	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	799	806	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	799	806	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	807	809	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	807	809	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	810	813	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	745	815	810	813	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	903	917	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	903	917	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	921	926	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	921	926	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	928	936	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	928	936	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	937	939	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	937	939	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	942	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	942	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	959	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	959	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	964	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP8	P40818	886	965	964	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GFO
USP40	Q9NVE5	1043	1064	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	793	811	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	354	389	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	231	279	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	1043	1064	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	793	811	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	354	389	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	231	279	1	1235	Chain	ID=PRO_0000080670;Note=Ubiquitin carboxyl-terminal hydrolase 40
USP40	Q9NVE5	354	389	41	482	Domain	Note=USP
USP40	Q9NVE5	231	279	41	482	Domain	Note=USP
USP40	Q9NVE5	354	389	41	482	Domain	Note=USP
USP40	Q9NVE5	231	279	41	482	Domain	Note=USP
USP40	Q9NVE5	793	811	1	824	Alternative sequence	ID=VSP_008595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	354	389	1	824	Alternative sequence	ID=VSP_008595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	231	279	1	824	Alternative sequence	ID=VSP_008595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	793	811	1	824	Alternative sequence	ID=VSP_008595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	354	389	1	824	Alternative sequence	ID=VSP_008595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	231	279	1	824	Alternative sequence	ID=VSP_008595;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	1043	1064	988	1235	Alternative sequence	ID=VSP_012819;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	1043	1064	988	1235	Alternative sequence	ID=VSP_012819;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP40	Q9NVE5	231	279	277	318	Sequence conflict	Note=CEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGN->FFSFNQKMHNVCVNRRYGGSGMPLLRCGRCVGSAQPLSSVFR;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP40	Q9NVE5	231	279	277	318	Sequence conflict	Note=CEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGN->FFSFNQKMHNVCVNRRYGGSGMPLLRCGRCVGSAQPLSSVFR;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP41	Q3LFD5	241	297	1	358	Chain	ID=PRO_0000328882;Note=Putative ubiquitin carboxyl-terminal hydrolase 41
USP41	Q3LFD5	241	297	55	358	Domain	Note=USP
USP5	P45974	353	376	2	858	Chain	ID=PRO_0000080623;Note=Ubiquitin carboxyl-terminal hydrolase 5
USP5	P45974	353	376	326	856	Domain	Note=USP
USP5	P45974	353	376	195	816	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.23
USP5	P45974	353	376	348	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHP
USP5	P45974	353	376	355	357	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHP
USP5	P45974	353	376	358	364	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHP
USP5	P45974	353	376	369	371	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHP
USP5	P45974	353	376	373	385	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IHP
UBXN1	Q04323	178	217	2	297	Chain	ID=PRO_0000211023;Note=UBX domain-containing protein 1
UBXN1	Q04323	20	37	2	297	Chain	ID=PRO_0000211023;Note=UBX domain-containing protein 1
UBXN1	Q04323	20	37	2	42	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
UBXN1	Q04323	178	217	211	293	Domain	Note=UBX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00215
UBXN1	Q04323	178	217	43	297	Region	Note=Interaction with BRCA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20351172;Dbxref=PMID:20351172
UBXN1	Q04323	178	217	199	199	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
UBXN1	Q04323	178	217	200	200	Modified residue	Note=Phosphoserine%3B by MAPK12;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15362974;Dbxref=PMID:15362974
UBXN1	Q04323	178	217	207	207	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
UBQLN4	Q9NRR5	422	450	1	601	Chain	ID=PRO_0000211015;Note=Ubiquilin-4
UBQLN4	Q9NRR5	422	450	393	440	Domain	Note=STI1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBQLN4	Q9NRR5	422	450	444	476	Domain	Note=STI1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBQLN4	Q9NRR5	422	450	227	601	Alternative sequence	ID=VSP_041188;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UCHL5	Q9Y5K5	282	315	1	329	Chain	ID=PRO_0000211066;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L5
UCHL5	Q9Y5K5	82	124	1	329	Chain	ID=PRO_0000211066;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L5
UCHL5	Q9Y5K5	282	315	313	329	Region	Note=Interaction with ADRM1
UCHL5	Q9Y5K5	82	124	88	88	Active site	Note=Nucleophile;Ontology_term=ECO:0000305;evidence=ECO:0000305
UCHL5	Q9Y5K5	282	315	289	289	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUP7
UCHL5	Q9Y5K5	82	124	88	88	Mutagenesis	Note=Abolishes enzymatic activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16906146;Dbxref=PMID:16906146
UCHL5	Q9Y5K5	82	124	85	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RII
UCHL5	Q9Y5K5	82	124	88	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RII
UCHL5	Q9Y5K5	82	124	109	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RII
UCHL5	Q9Y5K5	82	124	123	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RII
UCHL5	Q9Y5K5	282	315	255	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UEL
UCHL5	Q9Y5K5	282	315	293	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UEL
UCHL5	Q9Y5K5	282	315	309	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UEL
UBXN2B	Q14CS0	113	141	2	331	Chain	ID=PRO_0000315228;Note=UBX domain-containing protein 2B
UBXN2B	Q14CS0	178	223	2	331	Chain	ID=PRO_0000315228;Note=UBX domain-containing protein 2B
UBXN2B	Q14CS0	224	277	2	331	Chain	ID=PRO_0000315228;Note=UBX domain-containing protein 2B
UBXN2B	Q14CS0	113	141	141	206	Domain	Note=SEP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00732
UBXN2B	Q14CS0	178	223	141	206	Domain	Note=SEP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00732
UBXN2B	Q14CS0	224	277	252	329	Domain	Note=UBX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00215
UBXN2B	Q14CS0	224	277	231	231	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
UBXN2B	Q14CS0	224	277	234	234	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C627
UBXN2B	Q14CS0	224	277	235	235	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
UCP2	P55851	112	177	1	309	Chain	ID=PRO_0000090664;Note=Mitochondrial uncoupling protein 2
UCP2	P55851	112	177	101	119	Topological domain	Note=Mitochondrial matrix;Ontology_term=ECO:0000255;evidence=ECO:0000255
UCP2	P55851	112	177	120	136	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
UCP2	P55851	112	177	137	180	Topological domain	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000255;evidence=ECO:0000255
UCP2	P55851	112	177	114	203	Repeat	Note=Solcar 2
UCP2	P55851	112	177	154	154	Natural variant	ID=VAR_023999;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8;Dbxref=dbSNP:rs45486692
USP6NL	Q92738	308	359	1	828	Chain	ID=PRO_0000208056;Note=USP6 N-terminal-like protein
SLC14A1	Q13336	270	315	1	389	Chain	ID=PRO_0000065737;Note=Urea transporter 1
SLC14A1	Q13336	270	315	1	389	Chain	ID=PRO_0000065737;Note=Urea transporter 1
SLC14A1	Q13336	270	315	255	274	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC14A1	Q13336	270	315	255	274	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC14A1	Q13336	270	315	284	304	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC14A1	Q13336	270	315	284	304	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC14A1	Q13336	270	315	309	330	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC14A1	Q13336	270	315	309	330	Transmembrane	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250
SLC14A1	Q13336	270	315	280	280	Natural variant	ID=VAR_005669;Note=In Jk(b). D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9215669,ECO:0000269|Ref.6,ECO:0000269|Ref.8;Dbxref=dbSNP:rs1058396,PMID:15489334,PMID:9215669
SLC14A1	Q13336	270	315	280	280	Natural variant	ID=VAR_005669;Note=In Jk(b). D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9215669,ECO:0000269|Ref.6,ECO:0000269|Ref.8;Dbxref=dbSNP:rs1058396,PMID:15489334,PMID:9215669
SLC14A1	Q13336	270	315	291	291	Natural variant	ID=VAR_013752;Note=In Jk(null). S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10644814,ECO:0000269|PubMed:10942407;Dbxref=dbSNP:rs78242949,PMID:10644814,PMID:10942407
SLC14A1	Q13336	270	315	291	291	Natural variant	ID=VAR_013752;Note=In Jk(null). S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10644814,ECO:0000269|PubMed:10942407;Dbxref=dbSNP:rs78242949,PMID:10644814,PMID:10942407
SLC14A1	Q13336	270	315	299	299	Natural variant	ID=VAR_065467;Note=In Jk(null). G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18980618;Dbxref=dbSNP:rs538368217,PMID:18980618
SLC14A1	Q13336	270	315	299	299	Natural variant	ID=VAR_065467;Note=In Jk(null). G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18980618;Dbxref=dbSNP:rs538368217,PMID:18980618
TXNDC11	Q6PKC3	745	771	1	985	Chain	ID=PRO_0000120173;Note=Thioredoxin domain-containing protein 11
TXNDC11	Q6PKC3	264	291	1	985	Chain	ID=PRO_0000120173;Note=Thioredoxin domain-containing protein 11
TXNDC11	Q6PKC3	745	771	649	799	Domain	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TXNDC11	Q6PKC3	264	291	265	291	Alternative sequence	ID=VSP_014335;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TXNDC11	Q6PKC3	264	291	265	278	Alternative sequence	ID=VSP_014336;Note=In isoform 3. ALESTSSPRALVSF->DGVSPCRPGWSAVA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TXNDC11	Q6PKC3	745	771	279	985	Alternative sequence	ID=VSP_014337;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TXNDC11	Q6PKC3	264	291	279	985	Alternative sequence	ID=VSP_014337;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TDP2	O95551	212	269	1	362	Chain	ID=PRO_0000065678;Note=Tyrosyl-DNA phosphodiesterase 2
TDP2	O95551	84	141	1	362	Chain	ID=PRO_0000065678;Note=Tyrosyl-DNA phosphodiesterase 2
TDP2	O95551	84	141	120	120	Metal binding	Note=Magnesium;Ontology_term=ECO:0000305;evidence=ECO:0000305
TDP2	O95551	212	269	262	262	Metal binding	Note=Magnesium;Ontology_term=ECO:0000305;evidence=ECO:0000305
TDP2	O95551	212	269	264	264	Metal binding	Note=Magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250
TDP2	O95551	84	141	88	88	Modified residue	Note=Phosphothreonine%3B by ACVR1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18039968;Dbxref=PMID:18039968
TDP2	O95551	84	141	92	92	Modified residue	Note=Phosphothreonine%3B by ACVR1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18039968;Dbxref=PMID:18039968
TDP2	O95551	84	141	95	95	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TDP2	O95551	84	141	60	137	Alternative sequence	ID=VSP_038524;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TDP2	O95551	212	269	249	249	Natural variant	ID=VAR_022634;Note=Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs2294689
TDP2	O95551	212	269	268	268	Natural variant	ID=VAR_022635;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17249952
TDP2	O95551	84	141	88	88	Mutagenesis	Note=Abolishes function%2C but retains ability to interact with SMAD3%3B when associated with A-92. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18039968;Dbxref=PMID:18039968
TDP2	O95551	84	141	92	92	Mutagenesis	Note=Abolishes function%2C but retains ability to interact with SMAD3%3B when associated with A-88. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18039968;Dbxref=PMID:18039968
TDP2	O95551	84	141	120	120	Mutagenesis	Note=Strongly reduced phosphodiesterase activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22822062;Dbxref=PMID:22822062
TDP2	O95551	212	269	262	262	Mutagenesis	Note=Loss of phosphodiesterase activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19794497,ECO:0000269|PubMed:22822062;Dbxref=PMID:19794497,PMID:22822062
TDP2	O95551	84	141	113	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TDP2	O95551	84	141	129	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TDP2	O95551	212	269	207	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TDP2	O95551	212	269	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TDP2	O95551	212	269	231	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5INO
TDP2	O95551	212	269	234	249	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TDP2	O95551	212	269	255	262	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TDP2	O95551	212	269	269	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J3P
TYRO3	Q06418	193	222	41	890	Chain	ID=PRO_0000024478;Note=Tyrosine-protein kinase receptor TYRO3
TYRO3	Q06418	193	222	41	429	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
TYRO3	Q06418	193	222	139	220	Domain	Note=Ig-like C2-type 2
TYRO3	Q06418	193	222	160	203	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:14623883;Dbxref=PMID:14623883
TYRO3	Q06418	193	222	199	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RHF
TYRO3	Q06418	193	222	210	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RHF
TYRO3	Q06418	193	222	217	221	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RHF
EFTUD2	Q15029	905	941	1	972	Chain	ID=PRO_0000091563;Note=116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2	Q15029	620	654	1	972	Chain	ID=PRO_0000091563;Note=116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2	Q15029	573	620	1	972	Chain	ID=PRO_0000091563;Note=116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2	Q15029	905	941	1	972	Chain	ID=PRO_0000091563;Note=116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2	Q15029	620	654	1	972	Chain	ID=PRO_0000091563;Note=116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2	Q15029	573	620	1	972	Chain	ID=PRO_0000091563;Note=116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2	Q15029	620	654	637	637	Natural variant	ID=VAR_067582;Note=In MFDM. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22305528;Dbxref=dbSNP:rs387906879,PMID:22305528
EFTUD2	Q15029	620	654	637	637	Natural variant	ID=VAR_067582;Note=In MFDM. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22305528;Dbxref=dbSNP:rs387906879,PMID:22305528
EFTUD2	Q15029	573	620	619	619	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
EFTUD2	Q15029	573	620	619	619	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2D2	P62837	40	66	1	147	Chain	ID=PRO_0000082462;Note=Ubiquitin-conjugating enzyme E2 D2
UBE2D2	P62837	40	66	63	63	Mutagenesis	Note=Strongly reduced interaction with CNTO4. K->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15001359;Dbxref=PMID:15001359
UBE2D2	P62837	40	66	41	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4V3L
UBE2D2	P62837	40	66	44	47	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ESK
UBE2D2	P62837	40	66	49	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ESK
UBE2D2	P62837	40	66	58	61	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ESK
UBE2D2	P62837	40	66	66	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ESK
USP14	P54578	54	65	1	494	Chain	ID=PRO_0000080636;Note=Ubiquitin carboxyl-terminal hydrolase 14
USP14	P54578	65	100	1	494	Chain	ID=PRO_0000080636;Note=Ubiquitin carboxyl-terminal hydrolase 14
USP14	P54578	345	388	1	494	Chain	ID=PRO_0000080636;Note=Ubiquitin carboxyl-terminal hydrolase 14
USP14	P54578	408	444	1	494	Chain	ID=PRO_0000080636;Note=Ubiquitin carboxyl-terminal hydrolase 14
USP14	P54578	54	65	4	80	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
USP14	P54578	65	100	4	80	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
USP14	P54578	345	388	105	483	Domain	Note=USP
USP14	P54578	408	444	105	483	Domain	Note=USP
USP14	P54578	408	444	435	435	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10092,ECO:0000255|PROSITE-ProRule:PRU10093
USP14	P54578	408	444	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
USP14	P54578	54	65	55	65	Alternative sequence	ID=VSP_057292;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP14	P54578	65	100	55	65	Alternative sequence	ID=VSP_057292;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP14	P54578	65	100	66	100	Alternative sequence	ID=VSP_047343;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
USP14	P54578	345	388	351	354	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	345	388	356	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	345	388	361	366	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	345	388	367	371	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	345	388	372	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	408	444	409	412	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	408	444	416	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP14	P54578	408	444	433	443	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AYN
USP21	Q9UK80	200	220	1	565	Chain	ID=PRO_0000080648;Note=Ubiquitin carboxyl-terminal hydrolase 21
USP21	Q9UK80	200	220	1	565	Chain	ID=PRO_0000080648;Note=Ubiquitin carboxyl-terminal hydrolase 21
USP21	Q9UK80	200	220	212	558	Domain	Note=USP
USP21	Q9UK80	200	220	212	558	Domain	Note=USP
USP21	Q9UK80	200	220	217	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MTN
USP21	Q9UK80	200	220	217	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MTN
USP25	Q9UHP3	15	41	1	1055	Chain	ID=PRO_0000080653;Note=Ubiquitin carboxyl-terminal hydrolase 25
USP25	Q9UHP3	185	214	1	1055	Chain	ID=PRO_0000080653;Note=Ubiquitin carboxyl-terminal hydrolase 25
USP25	Q9UHP3	435	488	1	1055	Chain	ID=PRO_0000080653;Note=Ubiquitin carboxyl-terminal hydrolase 25
USP25	Q9UHP3	664	731	1	1055	Chain	ID=PRO_0000080653;Note=Ubiquitin carboxyl-terminal hydrolase 25
USP25	Q9UHP3	779	811	1	1055	Chain	ID=PRO_0000080653;Note=Ubiquitin carboxyl-terminal hydrolase 25
USP25	Q9UHP3	15	41	14	57	Domain	Note=UBA-like
USP25	Q9UHP3	185	214	169	657	Domain	Note=USP
USP25	Q9UHP3	435	488	169	657	Domain	Note=USP
USP25	Q9UHP3	664	731	684	717	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
USP25	Q9UHP3	779	811	779	779	Alternative sequence	ID=VSP_039632;Note=In isoform USP25b. S->SIMMTPNMQGIIMAIGKSRSVYDRCGPEAGFFK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10644437;Dbxref=PMID:10644437
USP25	Q9UHP3	779	811	779	779	Alternative sequence	ID=VSP_039631;Note=In isoform USP25m. S->SKPENTTSQPLSNQRVVEVAIPHVGKFMIESKEGGYDDEIMMTPNMQGIIMAIGKSRSVYDRCGPEAGFFK;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
USP25	Q9UHP3	15	41	12	27	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MUX
USP25	Q9UHP3	15	41	33	43	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MUX
USP31	Q70CQ4	725	778	1	1352	Chain	ID=PRO_0000249518;Note=Ubiquitin carboxyl-terminal hydrolase 31
USP31	Q70CQ4	610	650	1	1352	Chain	ID=PRO_0000249518;Note=Ubiquitin carboxyl-terminal hydrolase 31
USP31	Q70CQ4	541	566	1	1352	Chain	ID=PRO_0000249518;Note=Ubiquitin carboxyl-terminal hydrolase 31
USP31	Q70CQ4	725	778	128	765	Domain	Note=USP
USP31	Q70CQ4	610	650	128	765	Domain	Note=USP
USP31	Q70CQ4	541	566	128	765	Domain	Note=USP
USP31	Q70CQ4	725	778	770	1221	Compositional bias	Note=Ser-rich
USP31	Q70CQ4	610	650	1	697	Alternative sequence	ID=VSP_020459;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP31	Q70CQ4	541	566	1	697	Alternative sequence	ID=VSP_020459;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP31	Q70CQ4	725	778	698	725	Alternative sequence	ID=VSP_020460;Note=In isoform 2. LGRDPEDYIYDLYAVCNHHGTMQGGHYT->MSQRDGVCGSHEVAGAASPGADGGLSLA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP31	Q70CQ4	541	566	552	552	Natural variant	ID=VAR_027425;Note=A->T;Dbxref=dbSNP:rs9932912
USP31	Q70CQ4	610	650	624	624	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP35	Q9P2H5	346	399	1	1018	Chain	ID=PRO_0000080665;Note=Ubiquitin carboxyl-terminal hydrolase 35
USP38	Q8NB14	316	350	1	1042	Chain	ID=PRO_0000080668;Note=Ubiquitin carboxyl-terminal hydrolase 38
USP38	Q8NB14	316	350	303	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RXX
USP38	Q8NB14	316	350	320	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RXX
USP38	Q8NB14	316	350	324	326	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RXX
USP38	Q8NB14	316	350	327	340	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RXX
USP38	Q8NB14	316	350	346	351	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RXX
UBR3	Q6ZT12	281	329	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	935	970	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	1673	1733	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	1733	1803	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	281	329	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	935	970	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	1673	1733	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	1733	1803	1	1888	Chain	ID=PRO_0000278184;Note=E3 ubiquitin-protein ligase UBR3
UBR3	Q6ZT12	935	970	919	939	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBR3	Q6ZT12	935	970	919	939	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBR3	Q6ZT12	1733	1803	1766	1808	Compositional bias	Note=Cys-rich
UBR3	Q6ZT12	1733	1803	1766	1808	Compositional bias	Note=Cys-rich
UBR3	Q6ZT12	281	329	1	1494	Alternative sequence	ID=VSP_023141;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
UBR3	Q6ZT12	935	970	1	1494	Alternative sequence	ID=VSP_023141;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
UBR3	Q6ZT12	281	329	1	1494	Alternative sequence	ID=VSP_023141;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
UBR3	Q6ZT12	935	970	1	1494	Alternative sequence	ID=VSP_023141;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
UBR3	Q6ZT12	281	329	1	1179	Alternative sequence	ID=VSP_030354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR3	Q6ZT12	935	970	1	1179	Alternative sequence	ID=VSP_030354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR3	Q6ZT12	281	329	1	1179	Alternative sequence	ID=VSP_030354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR3	Q6ZT12	935	970	1	1179	Alternative sequence	ID=VSP_030354;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBR3	Q6ZT12	1733	1803	1791	1791	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBR3	Q6ZT12	1733	1803	1791	1791	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBXN7	O94888	96	118	2	489	Chain	ID=PRO_0000211035;Note=UBX domain-containing protein 7
UBXN7	O94888	96	118	99	99	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
UGGT1	Q9NYU2	1238	1271	43	1555	Chain	ID=PRO_0000012271;Note=UDP-glucose:glycoprotein glucosyltransferase 1
UGGT1	Q9NYU2	1300	1361	43	1555	Chain	ID=PRO_0000012271;Note=UDP-glucose:glycoprotein glucosyltransferase 1
UGGT1	Q9NYU2	1238	1271	1244	1555	Region	Note=Glucosyltransferase;Ontology_term=ECO:0000250;evidence=ECO:0000250
UGGT1	Q9NYU2	1300	1361	1244	1555	Region	Note=Glucosyltransferase;Ontology_term=ECO:0000250;evidence=ECO:0000250
UHRF1BP1L	A0JNW5	368	429	1	1464	Chain	ID=PRO_0000295719;Note=UHRF1-binding protein 1-like
UHRF1BP1L	A0JNW5	223	280	1	1464	Chain	ID=PRO_0000295719;Note=UHRF1-binding protein 1-like
UHRF1BP1L	A0JNW5	368	429	414	414	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
UHRF1BP1L	A0JNW5	368	429	418	418	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
UHMK1	Q8TAS1	187	251	1	419	Chain	ID=PRO_0000086777;Note=Serine/threonine-protein kinase Kist
UHMK1	Q8TAS1	187	251	23	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000305
UHMK1	Q8TAS1	187	251	197	197	Natural variant	ID=VAR_041273;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56201055,PMID:17344846
TTC13	Q8NBP0	574	604	1	860	Chain	ID=PRO_0000106398;Note=Tetratricopeptide repeat protein 13
TTC13	Q8NBP0	263	300	1	860	Chain	ID=PRO_0000106398;Note=Tetratricopeptide repeat protein 13
TTC13	Q8NBP0	193	224	1	860	Chain	ID=PRO_0000106398;Note=Tetratricopeptide repeat protein 13
TTC13	Q8NBP0	193	224	216	248	Repeat	Note=TPR 2
TTC13	Q8NBP0	263	300	249	282	Repeat	Note=TPR 3
TTC13	Q8NBP0	263	300	284	316	Repeat	Note=TPR 4
TTC13	Q8NBP0	193	224	172	224	Alternative sequence	ID=VSP_011644;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:16303743,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:16303743,PMID:17974005
TTLL4	Q14679	658	722	1	1199	Chain	ID=PRO_0000212442;Note=Tubulin polyglutamylase TTLL4
TTLL4	Q14679	793	833	1	1199	Chain	ID=PRO_0000212442;Note=Tubulin polyglutamylase TTLL4
TTLL4	Q14679	912	957	1	1199	Chain	ID=PRO_0000212442;Note=Tubulin polyglutamylase TTLL4
TTLL4	Q14679	658	722	1	1199	Chain	ID=PRO_0000212442;Note=Tubulin polyglutamylase TTLL4
TTLL4	Q14679	793	833	1	1199	Chain	ID=PRO_0000212442;Note=Tubulin polyglutamylase TTLL4
TTLL4	Q14679	912	957	1	1199	Chain	ID=PRO_0000212442;Note=Tubulin polyglutamylase TTLL4
TTLL4	Q14679	658	722	604	947	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL4	Q14679	793	833	604	947	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL4	Q14679	912	957	604	947	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL4	Q14679	658	722	604	947	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL4	Q14679	793	833	604	947	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL4	Q14679	912	957	604	947	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL4	Q14679	912	957	918	1029	Region	Note=c-MTBD region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25959773;Dbxref=PMID:25959773
TTLL4	Q14679	912	957	918	1029	Region	Note=c-MTBD region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25959773;Dbxref=PMID:25959773
TTLL4	Q14679	658	722	691	691	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TTLL4	Q14679	658	722	691	691	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
TYK2	P29597	1106	1143	1	1187	Chain	ID=PRO_0000088177;Note=Non-receptor tyrosine-protein kinase TYK2
TYK2	P29597	337	403	1	1187	Chain	ID=PRO_0000088177;Note=Non-receptor tyrosine-protein kinase TYK2
TYK2	P29597	1106	1143	1	1187	Chain	ID=PRO_0000088177;Note=Non-receptor tyrosine-protein kinase TYK2
TYK2	P29597	337	403	1	1187	Chain	ID=PRO_0000088177;Note=Non-receptor tyrosine-protein kinase TYK2
TYK2	P29597	337	403	26	431	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
TYK2	P29597	337	403	26	431	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
TYK2	P29597	1106	1143	897	1176	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TYK2	P29597	1106	1143	897	1176	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TYK2	P29597	337	403	362	362	Natural variant	ID=VAR_020599;Note=V->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:2216457,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2304256,PMID:17344846,PMID:2216457
TYK2	P29597	337	403	362	362	Natural variant	ID=VAR_020599;Note=V->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:2216457,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2304256,PMID:17344846,PMID:2216457
TYK2	P29597	337	403	363	363	Natural variant	ID=VAR_020600;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2304255,PMID:17344846
TYK2	P29597	337	403	363	363	Natural variant	ID=VAR_020600;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2304255,PMID:17344846
TYK2	P29597	337	403	386	386	Natural variant	ID=VAR_041870;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55956017,PMID:17344846
TYK2	P29597	337	403	386	386	Natural variant	ID=VAR_041870;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55956017,PMID:17344846
TYK2	P29597	337	403	375	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	375	378	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	380	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	380	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	383	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	383	389	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	392	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	392	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	400	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	337	403	400	406	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PO6
TYK2	P29597	1106	1143	1104	1112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXP
TYK2	P29597	1106	1143	1104	1112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXP
TYK2	P29597	1106	1143	1117	1129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXP
TYK2	P29597	1106	1143	1117	1129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXP
TYK2	P29597	1106	1143	1142	1151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXP
TYK2	P29597	1106	1143	1142	1151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LXP
TTLL9	Q3SXZ7	168	191	1	439	Chain	ID=PRO_0000324517;Note=Probable tubulin polyglutamylase TTLL9
TTLL9	Q3SXZ7	168	191	1	439	Chain	ID=PRO_0000324517;Note=Probable tubulin polyglutamylase TTLL9
TTLL9	Q3SXZ7	168	191	40	380	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL9	Q3SXZ7	168	191	40	380	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL9	Q3SXZ7	168	191	169	191	Alternative sequence	ID=VSP_035766;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TTLL9	Q3SXZ7	168	191	169	191	Alternative sequence	ID=VSP_035766;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE2L6	O14933	9	41	1	153	Chain	ID=PRO_0000082478;Note=Ubiquitin/ISG15-conjugating enzyme E2 L6
UBE2L6	O14933	9	41	1	66	Alternative sequence	ID=VSP_037344;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
UBE2L6	O14933	9	41	4	16	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZV
UBE2L6	O14933	9	41	22	27	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZV
UBE2L6	O14933	9	41	34	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WZV
UBAP2	Q5T6F2	226	248	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	147	173	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	59	96	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	33	59	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	226	248	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	147	173	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	59	96	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	33	59	1	1119	Chain	ID=PRO_0000270981;Note=Ubiquitin-associated protein 2
UBAP2	Q5T6F2	59	96	48	92	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBAP2	Q5T6F2	33	59	48	92	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBAP2	Q5T6F2	59	96	48	92	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBAP2	Q5T6F2	33	59	48	92	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBAP2	Q5T6F2	147	173	166	166	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
UBAP2	Q5T6F2	147	173	166	166	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
UBAP2	Q5T6F2	226	248	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	147	173	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	59	96	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	33	59	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	226	248	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	147	173	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	59	96	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBAP2	Q5T6F2	33	59	1	761	Alternative sequence	ID=VSP_056073;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDC34	P49427	121	165	1	236	Chain	ID=PRO_0000082451;Note=Ubiquitin-conjugating enzyme E2 R1
CDC34	P49427	121	165	129	129	Mutagenesis	Note=No effect on activity%2C when assayed in a Sic1-SCF-cdc4 ubiquitination assay. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24316736;Dbxref=PMID:24316736
CDC34	P49427	121	165	129	129	Mutagenesis	Note=Complete loss of activity%2C when assayed in a Sic1-SCF-cdc4 ubiquitination assay. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24316736;Dbxref=PMID:24316736
CDC34	P49427	121	165	133	133	Mutagenesis	Note=No effect on activity%2C when assayed in a Sic1-SCF-cdc4 ubiquitination assay. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24316736;Dbxref=PMID:24316736
CDC34	P49427	121	165	138	138	Mutagenesis	Note=Decreases monoubiquitination of NFKBIA and inhibits polyubiquitination of NFKBIA. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698585;Dbxref=PMID:17698585
CDC34	P49427	121	165	143	143	Mutagenesis	Note=Inhibits polyubiquitination of NFKBIA%3B when associated with A-147%3B A-149%3B A-150 and A-153. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698585;Dbxref=PMID:17698585
CDC34	P49427	121	165	147	147	Mutagenesis	Note=Inhibits polyubiquitination of NFKBIA%3B when associated with A-143%3B A-149%3B A-150 and A-153. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698585;Dbxref=PMID:17698585
CDC34	P49427	121	165	149	149	Mutagenesis	Note=Inhibits polyubiquitination of NFKBIA%3B when associated with A-147%3B A-147%3B A-150 and A-153. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698585;Dbxref=PMID:17698585
CDC34	P49427	121	165	150	150	Mutagenesis	Note=Inhibits polyubiquitination of NFKBIA%3B when associated with A-143%3B A-147%3B A-149 and A-153. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698585;Dbxref=PMID:17698585
CDC34	P49427	121	165	153	153	Mutagenesis	Note=Inhibits polyubiquitination of NFKBIA%3B when associated with A-143%3B A-147%3B A-149 and A-150. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698585;Dbxref=PMID:17698585
CDC34	P49427	121	165	120	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RZ3
CDC34	P49427	121	165	142	153	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RZ3
CDC34	P49427	121	165	154	156	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RZ3
CDC34	P49427	121	165	160	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RZ3
UBE2E1	P51965	51	67	2	193	Chain	ID=PRO_0000082470;Note=Ubiquitin-conjugating enzyme E2 E1
UBE2E1	P51965	51	67	51	67	Alternative sequence	ID=VSP_047200;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE2E1	P51965	51	67	47	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LBN
UBE2E1	P51965	51	67	67	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LBN
UBA3	Q8TBC4	303	321	2	463	Chain	ID=PRO_0000194941;Note=NEDD8-activating enzyme E1 catalytic subunit
UBA3	Q8TBC4	61	88	2	463	Chain	ID=PRO_0000194941;Note=NEDD8-activating enzyme E1 catalytic subunit
UBA3	Q8TBC4	7	20	2	463	Chain	ID=PRO_0000194941;Note=NEDD8-activating enzyme E1 catalytic subunit
UBA3	Q8TBC4	61	88	53	70	Region	Note=Interaction with UBE2M N-terminus
UBA3	Q8TBC4	7	20	8	21	Alternative sequence	ID=VSP_041127;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBA3	Q8TBC4	7	20	9	9	Natural variant	ID=VAR_023945;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10207026,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852113,PMID:10207026,PMID:15489334
UBA3	Q8TBC4	61	88	65	65	Mutagenesis	Note=Reduces affinity for UBE2M. F->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15361859;Dbxref=PMID:15361859
UBA3	Q8TBC4	303	321	310	310	Mutagenesis	Note=No effect on NEDD8 adenylation or thioester intermediate formation%3B impairs NEDD8 transfer to UBE2M. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12646924;Dbxref=PMID:12646924
UBA3	Q8TBC4	61	88	63	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JJM
UBA3	Q8TBC4	61	88	72	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
UBA3	Q8TBC4	61	88	80	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
UBA3	Q8TBC4	303	321	299	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
UBA3	Q8TBC4	303	321	314	333	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TT5
UBE3C	Q15386	40	65	1	1083	Chain	ID=PRO_0000194982;Note=Ubiquitin-protein ligase E3C
UBE3C	Q15386	65	114	1	1083	Chain	ID=PRO_0000194982;Note=Ubiquitin-protein ligase E3C
UBE3C	Q15386	444	472	1	1083	Chain	ID=PRO_0000194982;Note=Ubiquitin-protein ligase E3C
UBE3C	Q15386	603	638	1	1083	Chain	ID=PRO_0000194982;Note=Ubiquitin-protein ligase E3C
UBE3C	Q15386	827	898	1	1083	Chain	ID=PRO_0000194982;Note=Ubiquitin-protein ligase E3C
UBE3C	Q15386	40	65	45	74	Domain	Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
UBE3C	Q15386	65	114	45	74	Domain	Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
UBE3C	Q15386	827	898	744	1083	Domain	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104
UBE3C	Q15386	40	65	1	60	Region	Note=Cis-determinant of acceptor ubiquitin-binding
UBE3C	Q15386	40	65	23	65	Alternative sequence	ID=VSP_013953;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3C	Q15386	65	114	23	65	Alternative sequence	ID=VSP_013953;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3C	Q15386	444	472	445	447	Alternative sequence	ID=VSP_013954;Note=In isoform 3. LLY->VYK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3C	Q15386	444	472	448	1083	Alternative sequence	ID=VSP_013955;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3C	Q15386	603	638	448	1083	Alternative sequence	ID=VSP_013955;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3C	Q15386	827	898	448	1083	Alternative sequence	ID=VSP_013955;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE3C	Q15386	827	898	650	1083	Alternative sequence	ID=VSP_013957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UGDH	O60701	421	458	1	494	Chain	ID=PRO_0000074060;Note=UDP-glucose 6-dehydrogenase
UGDH	O60701	88	155	1	494	Chain	ID=PRO_0000074060;Note=UDP-glucose 6-dehydrogenase
UGDH	O60701	54	88	1	494	Chain	ID=PRO_0000074060;Note=UDP-glucose 6-dehydrogenase
UGDH	O60701	421	458	1	494	Chain	ID=PRO_0000074060;Note=UDP-glucose 6-dehydrogenase
UGDH	O60701	88	155	1	494	Chain	ID=PRO_0000074060;Note=UDP-glucose 6-dehydrogenase
UGDH	O60701	54	88	1	494	Chain	ID=PRO_0000074060;Note=UDP-glucose 6-dehydrogenase
UGDH	O60701	88	155	89	93	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21502315;Dbxref=PMID:21502315
UGDH	O60701	88	155	89	93	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21502315;Dbxref=PMID:21502315
UGDH	O60701	88	155	130	131	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21502315;Dbxref=PMID:21502315
UGDH	O60701	88	155	130	131	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21502315;Dbxref=PMID:21502315
UGDH	O60701	421	458	442	442	Binding site	Note=Substrate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21502315;Dbxref=PMID:21502315
UGDH	O60701	421	458	442	442	Binding site	Note=Substrate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21502315;Dbxref=PMID:21502315
UGDH	O60701	88	155	107	107	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
UGDH	O60701	88	155	107	107	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
UGDH	O60701	88	155	1	97	Alternative sequence	ID=VSP_046234;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UGDH	O60701	54	88	1	97	Alternative sequence	ID=VSP_046234;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UGDH	O60701	88	155	1	97	Alternative sequence	ID=VSP_046234;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UGDH	O60701	54	88	1	97	Alternative sequence	ID=VSP_046234;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UGDH	O60701	88	155	89	155	Alternative sequence	ID=VSP_042550;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UGDH	O60701	88	155	89	155	Alternative sequence	ID=VSP_042550;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UGDH	O60701	54	88	57	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	57	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	65	67	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	65	67	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	75	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	75	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	83	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	54	88	83	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	95	97	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	98	102	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	98	102	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	107	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	122	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	122	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	136	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	136	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	88	155	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	418	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	418	422	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	425	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	425	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	444	447	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	444	447	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	449	455	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	449	455	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
UGDH	O60701	421	458	458	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VR8
USB1	Q9BQ65	150	167	1	265	Chain	ID=PRO_0000274391;Note=U6 snRNA phosphodiesterase
USB1	Q9BQ65	203	231	1	265	Chain	ID=PRO_0000274391;Note=U6 snRNA phosphodiesterase
USB1	Q9BQ65	203	231	208	208	Active site	Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23190533;Dbxref=PMID:23190533
USB1	Q9BQ65	150	167	150	265	Alternative sequence	ID=VSP_042936;Note=In isoform 3. RFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLDLVSEVDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVDGFEDAEVLLRVHTEQVRCKSGNKFFSMPLK->SPHPGPHCLIGTKDAPVTQEIPKDLGALRQEPGSQTR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USB1	Q9BQ65	203	231	150	265	Alternative sequence	ID=VSP_042936;Note=In isoform 3. RFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLDLVSEVDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVDGFEDAEVLLRVHTEQVRCKSGNKFFSMPLK->SPHPGPHCLIGTKDAPVTQEIPKDLGALRQEPGSQTR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USB1	Q9BQ65	150	167	150	167	Alternative sequence	ID=VSP_042878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USB1	Q9BQ65	203	231	208	208	Mutagenesis	Note=Abolishes exoribonuclease activity. No rescue of the molecular phenotype caused by USB1 depletion. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22899009,ECO:0000269|PubMed:23190533;Dbxref=PMID:22899009,PMID:23190533
USB1	Q9BQ65	203	231	209	209	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
USB1	Q9BQ65	150	167	155	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H7W
USB1	Q9BQ65	150	167	166	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H7W
USB1	Q9BQ65	203	231	208	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H7W
USB1	Q9BQ65	203	231	219	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H7W
USB1	Q9BQ65	203	231	225	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4H7W
FERMT3	Q86UX7	298	343	1	667	Chain	ID=PRO_0000219454;Note=Fermitin family homolog 3
FERMT3	Q86UX7	441	519	1	667	Chain	ID=PRO_0000219454;Note=Fermitin family homolog 3
FERMT3	Q86UX7	298	343	229	558	Domain	Note=FERM
FERMT3	Q86UX7	441	519	229	558	Domain	Note=FERM
FERMT3	Q86UX7	441	519	354	457	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
FERMT3	Q86UX7	441	519	504	504	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
FERMT3	Q86UX7	441	519	472	472	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
FERMT3	Q86UX7	441	519	480	480	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
FERMT3	Q86UX7	441	519	429	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3
FERMT3	Q86UX7	441	519	442	456	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3
FERMT3	Q86UX7	441	519	465	480	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3
UTY	O14607	625	657	1	1347	Chain	ID=PRO_0000106411;Note=Histone demethylase UTY
UTY	O14607	625	657	625	625	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
UTY	O14607	625	657	644	644	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
TULP4	Q9NRJ4	84	127	1	1543	Chain	ID=PRO_0000186472;Note=Tubby-related protein 4
TULP4	Q9NRJ4	127	181	1	1543	Chain	ID=PRO_0000186472;Note=Tubby-related protein 4
TULP4	Q9NRJ4	84	127	73	115	Repeat	Note=WD 2
TULP4	Q9NRJ4	84	127	116	158	Repeat	Note=WD 3
TULP4	Q9NRJ4	127	181	116	158	Repeat	Note=WD 3
TULP4	Q9NRJ4	127	181	159	237	Repeat	Note=WD 4
TUSC3	Q13454	142	189	42	348	Chain	ID=PRO_0000215300;Note=Tumor suppressor candidate 3
TUSC3	Q13454	189	236	42	348	Chain	ID=PRO_0000215300;Note=Tumor suppressor candidate 3
TUSC3	Q13454	142	189	42	196	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUSC3	Q13454	189	236	42	196	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUSC3	Q13454	189	236	197	217	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUSC3	Q13454	189	236	218	221	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUSC3	Q13454	189	236	222	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
TUSC3	Q13454	142	189	59	187	Domain	Note=Thioredoxin
TUSC3	Q13454	142	189	137	142	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M91
TUSC3	Q13454	142	189	150	154	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M91
TUSC3	Q13454	142	189	156	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M91
TUSC3	Q13454	142	189	162	164	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M91
TUSC3	Q13454	142	189	168	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M91
TUSC3	Q13454	142	189	175	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4M91
TXNDC12	O95881	118	146	27	172	Chain	ID=PRO_0000034189;Note=Thioredoxin domain-containing protein 12
TXNDC12	O95881	118	146	27	156	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
TXNDC12	O95881	118	146	112	118	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SEN
TXNDC12	O95881	118	146	120	122	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K8V
TXNDC12	O95881	118	146	135	139	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2K8V
TXNDC12	O95881	118	146	144	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SEN
TXLNG	Q9NUQ3	166	223	1	528	Chain	ID=PRO_0000189426;Note=Gamma-taxilin
TXLNG	Q9NUQ3	328	353	1	528	Chain	ID=PRO_0000189426;Note=Gamma-taxilin
TXLNG	Q9NUQ3	166	223	153	464	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TXLNG	Q9NUQ3	328	353	153	464	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TXLNG	Q9NUQ3	166	223	35	166	Alternative sequence	ID=VSP_039391;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
NME9	Q86XW9	89	128	1	330	Chain	ID=PRO_0000120161;Note=Thioredoxin domain-containing protein 6
NME9	Q86XW9	65	89	1	330	Chain	ID=PRO_0000120161;Note=Thioredoxin domain-containing protein 6
NME9	Q86XW9	89	128	11	115	Domain	Note=Thioredoxin
NME9	Q86XW9	65	89	11	115	Domain	Note=Thioredoxin
NME9	Q86XW9	89	128	66	128	Alternative sequence	ID=VSP_010376;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NME9	Q86XW9	65	89	66	128	Alternative sequence	ID=VSP_010376;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
NME9	Q86XW9	89	128	90	128	Alternative sequence	ID=VSP_010377;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TXNDC9	O14530	103	187	1	226	Chain	ID=PRO_0000120166;Note=Thioredoxin domain-containing protein 9
TXNDC9	O14530	103	187	74	180	Domain	Note=Thioredoxin
TXNDC9	O14530	103	187	122	122	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
TYW1	Q9NV66	91	125	1	732	Chain	ID=PRO_0000281826;Note=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
TYW1	Q9NV66	125	190	1	732	Chain	ID=PRO_0000281826;Note=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
TYW1	Q9NV66	287	328	1	732	Chain	ID=PRO_0000281826;Note=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
TYW1	Q9NV66	566	603	1	732	Chain	ID=PRO_0000281826;Note=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
TYW1	Q9NV66	603	659	1	732	Chain	ID=PRO_0000281826;Note=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
TYW1	Q9NV66	91	125	79	237	Domain	Note=Flavodoxin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00088
TYW1	Q9NV66	125	190	79	237	Domain	Note=Flavodoxin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00088
TYW1	Q9NV66	125	190	176	208	Nucleotide binding	Note=FMN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00088
TYW1	Q9NV66	566	603	385	732	Alternative sequence	ID=VSP_024067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TYW1	Q9NV66	603	659	385	732	Alternative sequence	ID=VSP_024067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TYW1	Q9NV66	603	659	632	632	Natural variant	ID=VAR_031289;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2949097,PMID:14702039
UBA7	P41226	905	936	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	841	905	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	696	721	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	437	489	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	374	410	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	313	374	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	264	313	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	75	120	1	1012	Chain	ID=PRO_0000194937;Note=Ubiquitin-like modifier-activating enzyme 7
UBA7	P41226	75	120	23	159	Repeat	Note=1-1
UBA7	P41226	437	489	423	575	Repeat	Note=1-2
UBA7	P41226	437	489	442	471	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
UBA7	P41226	437	489	23	575	Region	Note=2 approximate repeats
UBA7	P41226	374	410	23	575	Region	Note=2 approximate repeats
UBA7	P41226	313	374	23	575	Region	Note=2 approximate repeats
UBA7	P41226	264	313	23	575	Region	Note=2 approximate repeats
UBA7	P41226	75	120	23	575	Region	Note=2 approximate repeats
UBA7	P41226	264	313	266	266	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
UBA7	P41226	905	936	397	1012	Natural variant	ID=VAR_080759;Note=Found in a small consanguineous family with learning disability%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838
UBA7	P41226	841	905	397	1012	Natural variant	ID=VAR_080759;Note=Found in a small consanguineous family with learning disability%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838
UBA7	P41226	696	721	397	1012	Natural variant	ID=VAR_080759;Note=Found in a small consanguineous family with learning disability%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838
UBA7	P41226	437	489	397	1012	Natural variant	ID=VAR_080759;Note=Found in a small consanguineous family with learning disability%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838
UBA7	P41226	374	410	397	1012	Natural variant	ID=VAR_080759;Note=Found in a small consanguineous family with learning disability%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838
UBA7	P41226	696	721	712	712	Natural variant	ID=VAR_052434;Note=P->S;Dbxref=dbSNP:rs11928913
UBA7	P41226	374	410	355	378	Sequence conflict	Note=GVLSPMVAMLGAVAAQEVLKAISR->RCLEPMVACWVSSCPGSAEGNLQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBA7	P41226	313	374	355	378	Sequence conflict	Note=GVLSPMVAMLGAVAAQEVLKAISR->RCLEPMVACWVSSCPGSAEGNLQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBA7	P41226	374	410	355	378	Sequence conflict	Note=GVLSPMVAMLGAVAAQEVLKAISR->RCLEPMVACWVSSCPGSAEGNLQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBA7	P41226	313	374	355	378	Sequence conflict	Note=GVLSPMVAMLGAVAAQEVLKAISR->RCLEPMVACWVSSCPGSAEGNLQ;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP13	Q92995	418	460	1	863	Chain	ID=PRO_0000080635;Note=Ubiquitin carboxyl-terminal hydrolase 13
USP13	Q92995	649	697	1	863	Chain	ID=PRO_0000080635;Note=Ubiquitin carboxyl-terminal hydrolase 13
USP13	Q92995	418	460	336	861	Domain	Note=USP
USP13	Q92995	649	697	336	861	Domain	Note=USP
USP13	Q92995	649	697	652	693	Domain	Note=UBA 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
USP13	Q92995	649	697	664	664	Mutagenesis	Note=Impairs ability to stabilize SIAH2. Abolishes ability to stabilize SIAH2%3B when associated with E-739. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512
USP13	Q92995	649	697	656	662	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBC
USP13	Q92995	649	697	669	678	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBC
USP13	Q92995	649	697	683	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBC
USP13	Q92995	649	697	693	695	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBC
USP13	Q92995	649	697	697	700	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBC
USP15	Q9Y4E8	228	256	2	981	Chain	ID=PRO_0000080641;Note=Ubiquitin carboxyl-terminal hydrolase 15
USP15	Q9Y4E8	305	363	2	981	Chain	ID=PRO_0000080641;Note=Ubiquitin carboxyl-terminal hydrolase 15
USP15	Q9Y4E8	363	416	2	981	Chain	ID=PRO_0000080641;Note=Ubiquitin carboxyl-terminal hydrolase 15
USP15	Q9Y4E8	416	491	2	981	Chain	ID=PRO_0000080641;Note=Ubiquitin carboxyl-terminal hydrolase 15
USP15	Q9Y4E8	305	363	289	933	Domain	Note=USP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01035
USP15	Q9Y4E8	363	416	289	933	Domain	Note=USP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01035
USP15	Q9Y4E8	416	491	289	933	Domain	Note=USP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01035
USP15	Q9Y4E8	228	256	229	229	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
USP15	Q9Y4E8	228	256	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
USP15	Q9Y4E8	228	256	217	256	Alternative sequence	ID=VSP_005260;Note=In isoform 3. DGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNR->QKNEDGTWPRGPSTP;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9
USP15	Q9Y4E8	228	256	228	256	Alternative sequence	ID=VSP_005261;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9628581,ECO:0000303|Ref.1;Dbxref=PMID:15489334,PMID:9628581
USP15	Q9Y4E8	228	256	229	235	Alternative sequence	ID=VSP_045165;Note=In isoform 4. SPGASNF->KPLEQSC;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
USP15	Q9Y4E8	228	256	236	981	Alternative sequence	ID=VSP_045166;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
USP15	Q9Y4E8	305	363	236	981	Alternative sequence	ID=VSP_045166;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
USP15	Q9Y4E8	363	416	236	981	Alternative sequence	ID=VSP_045166;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
USP15	Q9Y4E8	416	491	236	981	Alternative sequence	ID=VSP_045166;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
USP43	Q70EL4	247	277	1	1123	Chain	ID=PRO_0000249521;Note=Ubiquitin carboxyl-terminal hydrolase 43
USP43	Q70EL4	486	511	1	1123	Chain	ID=PRO_0000249521;Note=Ubiquitin carboxyl-terminal hydrolase 43
USP43	Q70EL4	670	723	1	1123	Chain	ID=PRO_0000249521;Note=Ubiquitin carboxyl-terminal hydrolase 43
USP43	Q70EL4	247	277	101	710	Domain	Note=USP
USP43	Q70EL4	486	511	101	710	Domain	Note=USP
USP43	Q70EL4	670	723	101	710	Domain	Note=USP
USP43	Q70EL4	247	277	1	488	Alternative sequence	ID=VSP_020466;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP43	Q70EL4	486	511	1	488	Alternative sequence	ID=VSP_020466;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP43	Q70EL4	247	277	1	311	Alternative sequence	ID=VSP_020467;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP43	Q70EL4	486	511	489	553	Alternative sequence	ID=VSP_020468;Note=In isoform 2. HLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEE->MPTVCGSSSRRISSTAVPWMNVFSSTPRRSRSRPGGPCPGREGGWLPLVGWPRAAGASQSGWFAF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
USP43	Q70EL4	670	723	666	670	Alternative sequence	ID=VSP_046779;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TWSG1	Q9GZX9	74	163	26	223	Chain	ID=PRO_0000278808;Note=Twisted gastrulation protein homolog 1
TWSG1	Q9GZX9	74	163	26	77	Compositional bias	Note=Cys-rich
TWSG1	Q9GZX9	74	163	81	81	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
TWSG1	Q9GZX9	74	163	75	75	Alternative sequence	ID=VSP_042538;Note=In isoform 2. G->D;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TWSG1	Q9GZX9	74	163	76	223	Alternative sequence	ID=VSP_042539;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TTLL5	Q6EMB2	247	280	1	1281	Chain	ID=PRO_0000223341;Note=Tubulin polyglutamylase TTLL5
TTLL5	Q6EMB2	311	347	1	1281	Chain	ID=PRO_0000223341;Note=Tubulin polyglutamylase TTLL5
TTLL5	Q6EMB2	427	465	1	1281	Chain	ID=PRO_0000223341;Note=Tubulin polyglutamylase TTLL5
TTLL5	Q6EMB2	247	280	62	407	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL5	Q6EMB2	311	347	62	407	Domain	Note=TTL;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00568
TTLL5	Q6EMB2	427	465	378	488	Region	Note=c-MTBD region;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25959773;Dbxref=PMID:25959773
TTLL5	Q6EMB2	247	280	1	462	Alternative sequence	ID=VSP_037453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.5;Dbxref=PMID:11230166
TTLL5	Q6EMB2	311	347	1	462	Alternative sequence	ID=VSP_037453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.5;Dbxref=PMID:11230166
TTLL5	Q6EMB2	427	465	1	462	Alternative sequence	ID=VSP_037453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11230166,ECO:0000303|Ref.5;Dbxref=PMID:11230166
TTLL5	Q6EMB2	247	280	248	269	Alternative sequence	ID=VSP_037454;Note=In isoform 3. FATVRYDQGAKNIRNQFMHLTN->KCNWKMGNTMDKRRLPIYVQVL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TTLL5	Q6EMB2	247	280	270	1281	Alternative sequence	ID=VSP_037455;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TTLL5	Q6EMB2	311	347	270	1281	Alternative sequence	ID=VSP_037455;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TTLL5	Q6EMB2	427	465	270	1281	Alternative sequence	ID=VSP_037455;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
UBE2J2	Q8N2K1	138	165	1	259	Chain	ID=PRO_0000082596;Note=Ubiquitin-conjugating enzyme E2 J2
UBE2J2	Q8N2K1	0	43	1	259	Chain	ID=PRO_0000082596;Note=Ubiquitin-conjugating enzyme E2 J2
UBE2J2	Q8N2K1	138	165	1	259	Chain	ID=PRO_0000082596;Note=Ubiquitin-conjugating enzyme E2 J2
UBE2J2	Q8N2K1	0	43	1	259	Chain	ID=PRO_0000082596;Note=Ubiquitin-conjugating enzyme E2 J2
UBE2J2	Q8N2K1	138	165	1	226	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBE2J2	Q8N2K1	0	43	1	226	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBE2J2	Q8N2K1	138	165	1	226	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBE2J2	Q8N2K1	0	43	1	226	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UBE2J2	Q8N2K1	0	43	1	44	Alternative sequence	ID=VSP_011572;Note=In isoform 2. MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEW->MWPQDIAGR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBE2J2	Q8N2K1	0	43	1	44	Alternative sequence	ID=VSP_011572;Note=In isoform 2. MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEW->MWPQDIAGR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBE2J2	Q8N2K1	0	43	2	2	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2J2	Q8N2K1	0	43	2	2	Sequence conflict	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2J2	Q8N2K1	0	43	13	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	0	43	13	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	0	43	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	0	43	32	37	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	0	43	40	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	0	43	40	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	138	165	136	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	138	165	136	151	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	138	165	154	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	138	165	154	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	138	165	161	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBE2J2	Q8N2K1	138	165	161	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2F4W
UBA5	Q9GZZ9	69	99	1	404	Chain	ID=PRO_0000194970;Note=Ubiquitin-like modifier-activating enzyme 5
UBA5	Q9GZZ9	193	228	1	404	Chain	ID=PRO_0000194970;Note=Ubiquitin-like modifier-activating enzyme 5
UBA5	Q9GZZ9	193	228	226	226	Metal binding	Note=Zinc;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20368332;Dbxref=PMID:20368332
UBA5	Q9GZZ9	69	99	83	83	Binding site	Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20368332;Dbxref=PMID:20368332
UBA5	Q9GZZ9	69	99	70	73	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	69	99	75	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	69	99	83	95	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	69	99	98	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	193	228	185	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	193	228	202	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	193	228	211	219	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBA5	Q9GZZ9	193	228	221	223	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8V
UBE2T	Q9NPD8	128	156	1	197	Chain	ID=PRO_0000082509;Note=Ubiquitin-conjugating enzyme E2 T
UBE2T	Q9NPD8	95	128	1	197	Chain	ID=PRO_0000082509;Note=Ubiquitin-conjugating enzyme E2 T
UBE2T	Q9NPD8	95	128	99	101	Mutagenesis	Note=No effect on FANCL-binding%2C nor on FANCL-dependent monoubiquitination of FANCD2. RPS->SPR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24389026;Dbxref=PMID:24389026
UBE2T	Q9NPD8	95	128	93	95	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ
UBE2T	Q9NPD8	95	128	104	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ
UBE2T	Q9NPD8	128	156	126	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ
UBE2T	Q9NPD8	95	128	126	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ
UBE2T	Q9NPD8	128	156	136	150	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ
UBE2T	Q9NPD8	128	156	151	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ
UBE2B	P63146	50	80	1	152	Chain	ID=PRO_0000082447;Note=Ubiquitin-conjugating enzyme E2 B
UBE2B	P63146	50	80	54	54	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBE2B	P63146	50	80	47	50	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YB6
UBE2B	P63146	50	80	52	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YB6
UBE2B	P63146	50	80	61	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YB6
UBE2B	P63146	50	80	69	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YB6
UBE2C	O00762	43	72	2	179	Chain	ID=PRO_0000082560;Note=Ubiquitin-conjugating enzyme E2 C
UBE2C	O00762	43	72	44	72	Alternative sequence	ID=VSP_045648;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBE2C	O00762	43	72	30	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YII
UBE2C	O00762	43	72	50	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YII
UBE2C	O00762	43	72	61	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YII
UBP1	Q9NZI7	273	309	1	540	Chain	ID=PRO_0000229026;Note=Upstream-binding protein 1
UBP1	Q9NZI7	273	309	1	540	Chain	ID=PRO_0000229026;Note=Upstream-binding protein 1
UBP1	Q9NZI7	273	309	274	309	Alternative sequence	ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710
UBP1	Q9NZI7	273	309	274	309	Alternative sequence	ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710
UBP1	Q9NZI7	273	309	273	273	Sequence conflict	Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBP1	Q9NZI7	273	309	273	273	Sequence conflict	Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBP1	Q9NZI7	273	309	291	297	Sequence conflict	Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBP1	Q9NZI7	273	309	291	297	Sequence conflict	Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	294	335	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	238	294	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	61	101	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	294	335	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	238	294	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	61	101	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	294	335	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	238	294	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	61	101	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	294	335	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	238	294	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	61	101	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	294	335	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	238	294	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	61	101	1	380	Chain	ID=PRO_0000211021;Note=Ubiquitin-like protein 7
UBL7	Q96S82	61	101	18	98	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
UBL7	Q96S82	61	101	18	98	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
UBL7	Q96S82	61	101	18	98	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
UBL7	Q96S82	61	101	18	98	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
UBL7	Q96S82	61	101	18	98	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
UBL7	Q96S82	294	335	333	377	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
UBL7	Q96S82	294	335	333	377	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
UBL7	Q96S82	294	335	333	377	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
UBL7	Q96S82	294	335	333	377	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
UBL7	Q96S82	294	335	333	377	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
UBL7	Q96S82	238	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	262	262	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	272	272	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	272	272	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	272	272	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	272	272	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBL7	Q96S82	238	294	272	272	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBN1	Q9NPG3	520	568	1	1134	Chain	ID=PRO_0000065712;Note=Ubinuclein-1
UBN1	Q9NPG3	569	585	1	1134	Chain	ID=PRO_0000065712;Note=Ubinuclein-1
UBN1	Q9NPG3	1088	1118	1	1134	Chain	ID=PRO_0000065712;Note=Ubinuclein-1
UBN1	Q9NPG3	520	568	1	1134	Chain	ID=PRO_0000065712;Note=Ubinuclein-1
UBN1	Q9NPG3	569	585	1	1134	Chain	ID=PRO_0000065712;Note=Ubinuclein-1
UBN1	Q9NPG3	1088	1118	1	1134	Chain	ID=PRO_0000065712;Note=Ubinuclein-1
UBN1	Q9NPG3	520	568	479	542	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
UBN1	Q9NPG3	520	568	479	542	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
UBN1	Q9NPG3	1088	1118	1090	1119	Alternative sequence	ID=VSP_036971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBN1	Q9NPG3	1088	1118	1090	1119	Alternative sequence	ID=VSP_036971;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UBN2	Q6ZU65	187	221	1	1347	Chain	ID=PRO_0000295725;Note=Ubinuclein-2
UBN2	Q6ZU65	689	706	1	1347	Chain	ID=PRO_0000295725;Note=Ubinuclein-2
USP10	Q14694	50	397	2	798	Chain	ID=PRO_0000080629;Note=Ubiquitin carboxyl-terminal hydrolase 10
USP10	Q14694	714	736	2	798	Chain	ID=PRO_0000080629;Note=Ubiquitin carboxyl-terminal hydrolase 10
USP10	Q14694	714	736	415	795	Domain	Note=USP
USP10	Q14694	50	397	2	100	Region	Note=Interaction with p53/TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20096447;Dbxref=PMID:20096447
USP10	Q14694	50	397	100	100	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
USP10	Q14694	50	397	211	211	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P52479
USP10	Q14694	50	397	226	226	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
USP10	Q14694	50	397	321	321	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
USP10	Q14694	50	397	337	337	Modified residue	Note=Phosphoserine%3B by ATM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20096447;Dbxref=PMID:20096447
USP10	Q14694	50	397	365	365	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:20068231,PMID:24275569
USP10	Q14694	50	397	370	370	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163
USP10	Q14694	50	397	200	200	Natural variant	ID=VAR_015859;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs1862792,PMID:17974005
USP10	Q14694	50	397	203	203	Natural variant	ID=VAR_015860;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2326391,PMID:15489334
USP10	Q14694	50	397	204	204	Natural variant	ID=VAR_015861;Note=V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1812061,PMID:15489334
USP10	Q14694	50	397	337	337	Mutagenesis	Note=Abolishes phosphorylation by ATM%3B when associated with A-42. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20096447;Dbxref=PMID:20096447
USP10	Q14694	50	397	337	337	Mutagenesis	Note=Phospho-mimetic mutant that translocates to the nucleus in absence of genotoxic stress%3B when associated with E-42. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20096447;Dbxref=PMID:20096447
USP10	Q14694	50	397	108	108	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP10	Q14694	50	397	263	263	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP11	P51784	436	511	1	963	Chain	ID=PRO_0000080632;Note=Ubiquitin carboxyl-terminal hydrolase 11
USP11	P51784	511	539	1	963	Chain	ID=PRO_0000080632;Note=Ubiquitin carboxyl-terminal hydrolase 11
USP11	P51784	571	639	1	963	Chain	ID=PRO_0000080632;Note=Ubiquitin carboxyl-terminal hydrolase 11
USP11	P51784	436	511	309	930	Domain	Note=USP
USP11	P51784	511	539	309	930	Domain	Note=USP
USP11	P51784	571	639	309	930	Domain	Note=USP
USP11	P51784	436	511	489	489	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP20	Q9Y2K6	166	203	1	914	Chain	ID=PRO_0000080647;Note=Ubiquitin carboxyl-terminal hydrolase 20
USP20	Q9Y2K6	378	425	1	914	Chain	ID=PRO_0000080647;Note=Ubiquitin carboxyl-terminal hydrolase 20
USP20	Q9Y2K6	166	203	1	914	Chain	ID=PRO_0000080647;Note=Ubiquitin carboxyl-terminal hydrolase 20
USP20	Q9Y2K6	378	425	1	914	Chain	ID=PRO_0000080647;Note=Ubiquitin carboxyl-terminal hydrolase 20
USP20	Q9Y2K6	166	203	1	914	Chain	ID=PRO_0000080647;Note=Ubiquitin carboxyl-terminal hydrolase 20
USP20	Q9Y2K6	378	425	1	914	Chain	ID=PRO_0000080647;Note=Ubiquitin carboxyl-terminal hydrolase 20
USP20	Q9Y2K6	166	203	145	685	Domain	Note=USP
USP20	Q9Y2K6	378	425	145	685	Domain	Note=USP
USP20	Q9Y2K6	166	203	145	685	Domain	Note=USP
USP20	Q9Y2K6	378	425	145	685	Domain	Note=USP
USP20	Q9Y2K6	166	203	145	685	Domain	Note=USP
USP20	Q9Y2K6	378	425	145	685	Domain	Note=USP
USP20	Q9Y2K6	378	425	408	408	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
USP20	Q9Y2K6	378	425	408	408	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
USP20	Q9Y2K6	378	425	408	408	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
USP20	Q9Y2K6	378	425	413	413	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
USP20	Q9Y2K6	378	425	413	413	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
USP20	Q9Y2K6	378	425	413	413	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
USP30	Q70CQ3	64	125	1	517	Chain	ID=PRO_0000080662;Note=Ubiquitin carboxyl-terminal hydrolase 30
USP30	Q70CQ3	240	260	1	517	Chain	ID=PRO_0000080662;Note=Ubiquitin carboxyl-terminal hydrolase 30
USP30	Q70CQ3	289	316	1	517	Chain	ID=PRO_0000080662;Note=Ubiquitin carboxyl-terminal hydrolase 30
USP30	Q70CQ3	64	125	57	517	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
USP30	Q70CQ3	240	260	57	517	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
USP30	Q70CQ3	289	316	57	517	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
USP30	Q70CQ3	64	125	68	502	Domain	Note=USP
USP30	Q70CQ3	240	260	68	502	Domain	Note=USP
USP30	Q70CQ3	289	316	68	502	Domain	Note=USP
USP30	Q70CQ3	64	125	77	77	Active site	Note=Nucleophile;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18287522,ECO:0000269|PubMed:24896179,ECO:0000269|PubMed:25621951;Dbxref=PMID:18287522,PMID:24896179,PMID:25621951
USP30	Q70CQ3	289	316	289	289	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24896179;Dbxref=PMID:24896179
USP30	Q70CQ3	64	125	59	64	Mutagenesis	Note=Loss of mitochondrial subcellular location. Located in the endoplasmic reticulum. RKKRRK->NNASNN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18287522;Dbxref=PMID:18287522
USP30	Q70CQ3	64	125	77	77	Mutagenesis	Note=Loss of deubiquitinase activity and impaired ability to inhibit mitophagy. Increased TOMM20 ubiquitination. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18287522,ECO:0000269|PubMed:24896179,ECO:0000269|PubMed:25621951;Dbxref=PMID:18287522,PMID:24896179,PMID:25621951
USP30	Q70CQ3	64	125	73	75	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP30	Q70CQ3	64	125	77	87	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP30	Q70CQ3	64	125	90	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP30	Q70CQ3	64	125	101	104	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP30	Q70CQ3	64	125	116	127	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP30	Q70CQ3	240	260	240	254	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP30	Q70CQ3	289	316	306	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OHK
USP33	Q8TEY7	97	148	1	942	Chain	ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33
USP33	Q8TEY7	97	148	1	942	Chain	ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33
USP33	Q8TEY7	97	148	59	123	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
USP33	Q8TEY7	97	148	59	123	Zinc finger	Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502
USP33	Q8TEY7	97	148	91	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	91	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	103	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	107	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	107	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	111	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	111	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	115	118	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	115	118	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
USP33	Q8TEY7	97	148	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG
VWCE	Q96DN2	219	262	22	955	Chain	ID=PRO_0000318580;Note=von Willebrand factor C and EGF domain-containing protein
VWCE	Q96DN2	219	262	181	219	Domain	Note=EGF-like 3%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWCE	Q96DN2	219	262	220	262	Domain	Note=EGF-like 4%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWCE	Q96DN2	219	262	224	237	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWCE	Q96DN2	219	262	233	246	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWCE	Q96DN2	219	262	248	261	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VWCE	Q96DN2	219	262	219	219	Alternative sequence	ID=VSP_031230;Note=In isoform 2. V->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VWCE	Q96DN2	219	262	220	955	Alternative sequence	ID=VSP_031231;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VTI1A	Q96AJ9	88	114	1	217	Chain	ID=PRO_0000218225;Note=Vesicle transport through interaction with t-SNAREs homolog 1A
VTI1A	Q96AJ9	88	114	1	192	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VTI1A	Q96AJ9	88	114	31	92	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
VTI1A	Q96AJ9	88	114	112	178	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
WDR59	Q6PJI9	463	495	1	974	Chain	ID=PRO_0000280721;Note=GATOR complex protein WDR59
WDR59	Q6PJI9	217	243	1	974	Chain	ID=PRO_0000280721;Note=GATOR complex protein WDR59
WDR59	Q6PJI9	178	217	1	974	Chain	ID=PRO_0000280721;Note=GATOR complex protein WDR59
WDR59	Q6PJI9	178	217	146	185	Repeat	Note=WD 3
WDR59	Q6PJI9	217	243	189	229	Repeat	Note=WD 4
WDR59	Q6PJI9	178	217	189	229	Repeat	Note=WD 4
WDR59	Q6PJI9	217	243	232	276	Repeat	Note=WD 5
WDR59	Q6PJI9	463	495	393	494	Domain	Note=RWD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00179
WDR59	Q6PJI9	463	495	1	556	Alternative sequence	ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR59	Q6PJI9	217	243	1	556	Alternative sequence	ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR59	Q6PJI9	178	217	1	556	Alternative sequence	ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR59	Q6PJI9	217	243	1	408	Alternative sequence	ID=VSP_023882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874
WDR59	Q6PJI9	178	217	1	408	Alternative sequence	ID=VSP_023882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874
WDR59	Q6PJI9	178	217	201	201	Natural variant	ID=VAR_053436;Note=P->T;Dbxref=dbSNP:rs11557260
WDR33	Q9C0J8	1157	1188	2	1336	Chain	ID=PRO_0000051382;Note=pre-mRNA 3' end processing protein WDR33
WDR33	Q9C0J8	362	398	2	1336	Chain	ID=PRO_0000051382;Note=pre-mRNA 3' end processing protein WDR33
WDR33	Q9C0J8	362	398	329	369	Repeat	Note=WD 6
WDR33	Q9C0J8	362	398	373	412	Repeat	Note=WD 7
WDR33	Q9C0J8	1157	1188	327	1336	Alternative sequence	ID=VSP_041334;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
WDR33	Q9C0J8	362	398	327	1336	Alternative sequence	ID=VSP_041334;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
WDR33	Q9C0J8	362	398	368	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
WDR33	Q9C0J8	362	398	378	383	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
WDR33	Q9C0J8	362	398	387	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
WDR35	Q9P2L0	897	952	1	1181	Chain	ID=PRO_0000051384;Note=WD repeat-containing protein 35
WDR35	Q9P2L0	860	897	1	1181	Chain	ID=PRO_0000051384;Note=WD repeat-containing protein 35
WDR35	Q9P2L0	501	519	1	1181	Chain	ID=PRO_0000051384;Note=WD repeat-containing protein 35
WDR35	Q9P2L0	398	409	1	1181	Chain	ID=PRO_0000051384;Note=WD repeat-containing protein 35
WDR35	Q9P2L0	47	71	1	1181	Chain	ID=PRO_0000051384;Note=WD repeat-containing protein 35
WDR35	Q9P2L0	47	71	61	100	Repeat	Note=WD 2
WDR35	Q9P2L0	398	409	399	409	Alternative sequence	ID=VSP_009732;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
WDR35	Q9P2L0	897	952	527	1181	Natural variant	ID=VAR_080633;Note=In SRTD7%3B chondrocyte cell lines from the patient show a reduction of cilia indicating a defect in ciliogenesis. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28400947;Dbxref=PMID:28400947
WDR35	Q9P2L0	860	897	527	1181	Natural variant	ID=VAR_080633;Note=In SRTD7%3B chondrocyte cell lines from the patient show a reduction of cilia indicating a defect in ciliogenesis. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28400947;Dbxref=PMID:28400947
WDR35	Q9P2L0	860	897	875	875	Natural variant	ID=VAR_064582;Note=In CED2. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20817137;Dbxref=dbSNP:rs267607175,PMID:20817137
WDR35	Q9P2L0	860	897	878	878	Natural variant	ID=VAR_062102;Note=A->P;Dbxref=dbSNP:rs2293669
WDR35	Q9P2L0	860	897	878	878	Natural variant	ID=VAR_062103;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2293669,PMID:15489334
WDR41	Q9HAD4	195	232	1	459	Chain	ID=PRO_0000051390;Note=WD repeat-containing protein 41
WDR41	Q9HAD4	72	116	1	459	Chain	ID=PRO_0000051390;Note=WD repeat-containing protein 41
WDR41	Q9HAD4	72	116	40	79	Repeat	Note=WD 1
WDR41	Q9HAD4	72	116	82	128	Repeat	Note=WD 2
WDR41	Q9HAD4	195	232	220	258	Repeat	Note=WD 4
WDR41	Q9HAD4	72	116	18	72	Alternative sequence	ID=VSP_054014;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR93	Q6P2C0	374	403	1	686	Chain	ID=PRO_0000319603;Note=WD repeat-containing protein 93
WDR82	Q6UXN9	142	181	1	313	Chain	ID=PRO_0000279685;Note=WD repeat-containing protein 82
WDR82	Q6UXN9	142	181	105	144	Repeat	Note=WD 2
WDR82	Q6UXN9	142	181	146	184	Repeat	Note=WD 3
WDHD1	O75717	882	900	1	1129	Chain	ID=PRO_0000051338;Note=WD repeat and HMG-box DNA-binding protein 1
WDHD1	O75717	589	635	1	1129	Chain	ID=PRO_0000051338;Note=WD repeat and HMG-box DNA-binding protein 1
WDHD1	O75717	589	635	612	612	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDHD1	O75717	589	635	612	612	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDHD1	O75717	589	635	613	613	Sequence conflict	Note=I->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDHD1	O75717	589	635	599	605	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OGS
WDHD1	O75717	589	635	607	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OGS
WDHD1	O75717	589	635	611	618	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OGS
WDHD1	O75717	589	635	627	632	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OGS
WIPI2	Q9Y4P8	247	282	1	454	Chain	ID=PRO_0000051440;Note=WD repeat domain phosphoinositide-interacting protein 2
WIPI2	Q9Y4P8	247	282	238	277	Repeat	Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255
WNK2	Q9Y3S1	678	730	1	2297	Chain	ID=PRO_0000086822;Note=Serine/threonine-protein kinase WNK2
WNK2	Q9Y3S1	794	1022	1	2297	Chain	ID=PRO_0000086822;Note=Serine/threonine-protein kinase WNK2
WNK2	Q9Y3S1	1344	1381	1	2297	Chain	ID=PRO_0000086822;Note=Serine/threonine-protein kinase WNK2
WNK2	Q9Y3S1	2011	2075	1	2297	Chain	ID=PRO_0000086822;Note=Serine/threonine-protein kinase WNK2
WNK2	Q9Y3S1	2075	2108	1	2297	Chain	ID=PRO_0000086822;Note=Serine/threonine-protein kinase WNK2
WNK2	Q9Y3S1	2108	2123	1	2297	Chain	ID=PRO_0000086822;Note=Serine/threonine-protein kinase WNK2
WNK2	Q9Y3S1	2011	2075	2067	2067	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21733846;Dbxref=PMID:21733846
WNK2	Q9Y3S1	678	730	680	731	Alternative sequence	ID=VSP_050640;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	794	1022	843	845	Alternative sequence	ID=VSP_050641;Note=In isoform 3. LAA->RTR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	794	1022	846	2297	Alternative sequence	ID=VSP_050642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	1344	1381	846	2297	Alternative sequence	ID=VSP_050642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	2011	2075	846	2297	Alternative sequence	ID=VSP_050642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	2075	2108	846	2297	Alternative sequence	ID=VSP_050642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	2108	2123	846	2297	Alternative sequence	ID=VSP_050642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11280764;Dbxref=PMID:11280764
WNK2	Q9Y3S1	1344	1381	1345	1381	Alternative sequence	ID=VSP_050643;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214970;Dbxref=PMID:11214970
WNK2	Q9Y3S1	794	1022	828	828	Natural variant	ID=VAR_057114;Note=V->M;Dbxref=dbSNP:rs10761203
WNK2	Q9Y3S1	794	1022	974	974	Natural variant	ID=VAR_059773;Note=R->L;Dbxref=dbSNP:rs10114908
WNK3	Q9BYP7	1613	1623	1	1800	Chain	ID=PRO_0000086823;Note=Serine/threonine-protein kinase WNK3
WNK3	Q9BYP7	1613	1623	1	1800	Chain	ID=PRO_0000086823;Note=Serine/threonine-protein kinase WNK3
WNK3	Q9BYP7	1613	1623	1614	1624	Alternative sequence	ID=VSP_041933;Note=In isoform 3 and isoform 2. GKSCLINELEN->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11571656;Dbxref=PMID:10997877,PMID:11571656
WNK3	Q9BYP7	1613	1623	1614	1624	Alternative sequence	ID=VSP_041933;Note=In isoform 3 and isoform 2. GKSCLINELEN->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11571656;Dbxref=PMID:10997877,PMID:11571656
WTIP	A6NIX2	279	300	1	430	Chain	ID=PRO_0000328860;Note=Wilms tumor protein 1-interacting protein
WTIP	A6NIX2	361	384	1	430	Chain	ID=PRO_0000328860;Note=Wilms tumor protein 1-interacting protein
WTIP	A6NIX2	279	300	223	284	Domain	Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
WTIP	A6NIX2	279	300	288	348	Domain	Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
WTIP	A6NIX2	361	384	349	417	Domain	Note=LIM zinc-binding 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125
XPC	Q01831	300	330	2	940	Chain	ID=PRO_0000218293;Note=DNA repair protein complementing XP-C cells
XPC	Q01831	300	330	141	940	Alternative sequence	ID=VSP_055891;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
XPC	Q01831	300	330	314	314	Natural variant	ID=VAR_018897;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs3731126
XPO1	O14980	892	937	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	771	836	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	629	674	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	349	415	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	253	296	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	213	253	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	121	136	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	42	76	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	892	937	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	771	836	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	629	674	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	349	415	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	253	296	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	213	253	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	121	136	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	42	76	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	892	937	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	771	836	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	629	674	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	349	415	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	253	296	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	213	253	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	121	136	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	42	76	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
XPO1	O14980	42	76	46	112	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
XPO1	O14980	42	76	46	112	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
XPO1	O14980	42	76	46	112	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
XPO1	O14980	213	253	217	240	Repeat	Note=HEAT 1
XPO1	O14980	213	253	217	240	Repeat	Note=HEAT 1
XPO1	O14980	213	253	217	240	Repeat	Note=HEAT 1
XPO1	O14980	253	296	241	277	Repeat	Note=HEAT 2
XPO1	O14980	213	253	241	277	Repeat	Note=HEAT 2
XPO1	O14980	253	296	241	277	Repeat	Note=HEAT 2
XPO1	O14980	213	253	241	277	Repeat	Note=HEAT 2
XPO1	O14980	253	296	241	277	Repeat	Note=HEAT 2
XPO1	O14980	213	253	241	277	Repeat	Note=HEAT 2
XPO1	O14980	349	415	354	472	Repeat	Note=HEAT 3
XPO1	O14980	349	415	354	472	Repeat	Note=HEAT 3
XPO1	O14980	349	415	354	472	Repeat	Note=HEAT 3
XPO1	O14980	629	674	602	639	Repeat	Note=HEAT 6
XPO1	O14980	629	674	602	639	Repeat	Note=HEAT 6
XPO1	O14980	629	674	602	639	Repeat	Note=HEAT 6
XPO1	O14980	771	836	775	813	Repeat	Note=HEAT 7
XPO1	O14980	771	836	775	813	Repeat	Note=HEAT 7
XPO1	O14980	771	836	775	813	Repeat	Note=HEAT 7
XPO1	O14980	892	937	885	916	Repeat	Note=HEAT 8
XPO1	O14980	892	937	885	916	Repeat	Note=HEAT 8
XPO1	O14980	892	937	885	916	Repeat	Note=HEAT 8
XPO1	O14980	892	937	917	954	Repeat	Note=HEAT 9
XPO1	O14980	892	937	917	954	Repeat	Note=HEAT 9
XPO1	O14980	892	937	917	954	Repeat	Note=HEAT 9
XPO1	O14980	629	674	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	349	415	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	253	296	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	213	253	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	121	136	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	42	76	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	629	674	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	349	415	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	253	296	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	213	253	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	121	136	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	42	76	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	629	674	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	349	415	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	253	296	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	213	253	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	121	136	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	42	76	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
XPO1	O14980	349	415	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
XPO1	O14980	349	415	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
XPO1	O14980	349	415	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
XPO1	O14980	349	415	411	481	Region	Note=Interaction with RANBP3
XPO1	O14980	349	415	411	481	Region	Note=Interaction with RANBP3
XPO1	O14980	349	415	411	481	Region	Note=Interaction with RANBP3
XPO1	O14980	349	415	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
XPO1	O14980	349	415	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
XPO1	O14980	349	415	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
XPO1	O14980	771	836	800	820	Region	Note=Interaction with HIV-1 Rev
XPO1	O14980	771	836	800	820	Region	Note=Interaction with HIV-1 Rev
XPO1	O14980	771	836	800	820	Region	Note=Interaction with HIV-1 Rev
XPO1	O14980	349	415	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
XPO1	O14980	349	415	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
XPO1	O14980	349	415	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
XPO1	O14980	253	296	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	253	296	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	253	296	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
XPO1	O14980	349	415	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
XPO1	O14980	349	415	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
XPO1	O14980	349	415	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
XPO1	O14980	42	76	40	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	40	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	40	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	73	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	73	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	42	76	73	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	121	136	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	121	136	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	121	136	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	121	136	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	121	136	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	121	136	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	202	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	202	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	202	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	219	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	219	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	219	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	213	253	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	253	296	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	349	415	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	629	674	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
XPO1	O14980	771	836	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	771	836	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	887	906	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	887	906	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	887	906	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	908	931	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	908	931	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	908	931	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	932	934	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	932	934	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO1	O14980	892	937	932	934	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
XPO4	Q9C0E2	1055	1086	1	1151	Chain	ID=PRO_0000204711;Note=Exportin-4
XPO7	Q9UIA9	6	55	2	1087	Chain	ID=PRO_0000204713;Note=Exportin-7
XPO7	Q9UIA9	142	164	2	1087	Chain	ID=PRO_0000204713;Note=Exportin-7
XPO7	Q9UIA9	6	55	30	96	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
XPOT	O43592	281	360	1	962	Chain	ID=PRO_0000204716;Note=Exportin-T
XPOT	O43592	360	373	1	962	Chain	ID=PRO_0000204716;Note=Exportin-T
XPOT	O43592	484	524	1	962	Chain	ID=PRO_0000204716;Note=Exportin-T
XPOT	O43592	911	935	1	962	Chain	ID=PRO_0000204716;Note=Exportin-T
XPOT	O43592	935	954	1	962	Chain	ID=PRO_0000204716;Note=Exportin-T
XPOT	O43592	281	360	1	385	Region	Note=Necessary for interaction with Ran%2C nuclear localization and nuclear import
XPOT	O43592	360	373	1	385	Region	Note=Necessary for interaction with Ran%2C nuclear localization and nuclear import
XPOT	O43592	484	524	443	962	Region	Note=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export
XPOT	O43592	911	935	443	962	Region	Note=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export
XPOT	O43592	935	954	443	962	Region	Note=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export
XPOT	O43592	281	360	360	360	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
XPOT	O43592	360	373	360	360	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
XPR1	Q9UBH6	435	500	1	696	Chain	ID=PRO_0000315853;Note=Xenotropic and polytropic retrovirus receptor 1
XPR1	Q9UBH6	603	676	1	696	Chain	ID=PRO_0000315853;Note=Xenotropic and polytropic retrovirus receptor 1
XPR1	Q9UBH6	435	500	424	473	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
XPR1	Q9UBH6	435	500	474	496	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
XPR1	Q9UBH6	435	500	497	507	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
XPR1	Q9UBH6	603	676	529	696	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
XPR1	Q9UBH6	435	500	439	643	Domain	Note=EXS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00712
XPR1	Q9UBH6	603	676	439	643	Domain	Note=EXS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00712
XPR1	Q9UBH6	603	676	668	668	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
XPR1	Q9UBH6	435	500	437	501	Alternative sequence	ID=VSP_030748;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XPR1	Q9UBH6	435	500	491	491	Natural variant	ID=VAR_038350;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9990033;Dbxref=dbSNP:rs1061012,PMID:9990033
YY1	P25490	301	354	1	414	Chain	ID=PRO_0000047190;Note=Transcriptional repressor protein YY1
YY1	P25490	301	354	296	320	Zinc finger	Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
YY1	P25490	301	354	325	347	Zinc finger	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
YY1	P25490	301	354	353	377	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
YY1	P25490	301	354	257	341	Region	Note=Involved in nuclear matrix association
YY1	P25490	301	354	295	414	Region	Note=Binding to DNA
YY1	P25490	301	354	333	371	Region	Note=Involved in repression of activated transcription
YY1	P25490	301	354	303	303	Metal binding	Note=Zinc 1
YY1	P25490	301	354	316	316	Metal binding	Note=Zinc 1
YY1	P25490	301	354	320	320	Metal binding	Note=Zinc 1
YY1	P25490	301	354	327	327	Metal binding	Note=Zinc 2
YY1	P25490	301	354	330	330	Metal binding	Note=Zinc 2
YY1	P25490	301	354	343	343	Metal binding	Note=Zinc 2
YY1	P25490	301	354	347	347	Metal binding	Note=Zinc 2
YY1	P25490	301	354	179	414	Natural variant	ID=VAR_079202;Note=In GADEVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575647;Dbxref=PMID:28575647
YY1	P25490	301	354	320	320	Natural variant	ID=VAR_079203;Note=In GADEVS%3B unknown pathological significance. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575647;Dbxref=PMID:28575647
YY1	P25490	301	354	339	339	Natural variant	ID=VAR_079204;Note=In GADEVS%3B unknown pathological significance. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575647;Dbxref=PMID:28575647
YY1	P25490	301	354	344	414	Natural variant	ID=VAR_079205;Note=In GADEVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575647;Dbxref=PMID:28575647
YY1	P25490	301	354	306	309	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
YY1	P25490	301	354	310	317	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
YY1	P25490	301	354	318	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
YY1	P25490	301	354	328	330	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
YY1	P25490	301	354	333	336	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
YY1	P25490	301	354	337	343	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
YY1	P25490	301	354	344	346	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UBD
ZBTB48	P10074	348	379	1	688	Chain	ID=PRO_0000047272;Note=Telomere zinc finger-associated protein
ZBTB48	P10074	348	379	350	372	Zinc finger	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB48	P10074	348	379	378	401	Zinc finger	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042
ZBTB48	P10074	348	379	350	351	Sequence conflict	Note=FT->LP;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP24	Q9UPU5	2563	2600	1	2620	Chain	ID=PRO_0000080652;Note=Ubiquitin carboxyl-terminal hydrolase 24
USP24	Q9UPU5	2185	2222	1	2620	Chain	ID=PRO_0000080652;Note=Ubiquitin carboxyl-terminal hydrolase 24
USP24	Q9UPU5	2118	2150	1	2620	Chain	ID=PRO_0000080652;Note=Ubiquitin carboxyl-terminal hydrolase 24
USP24	Q9UPU5	518	550	1	2620	Chain	ID=PRO_0000080652;Note=Ubiquitin carboxyl-terminal hydrolase 24
USP24	Q9UPU5	2563	2600	2565	2565	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692
USP24	Q9UPU5	2118	2150	2134	2134	Natural variant	ID=VAR_047156;Note=Y->S;Dbxref=dbSNP:rs12753590
USP24	Q9UPU5	2563	2600	2576	2576	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP45	Q70EL2	691	720	1	814	Chain	ID=PRO_0000280561;Note=Ubiquitin carboxyl-terminal hydrolase 45
USP45	Q70EL2	691	720	1	814	Chain	ID=PRO_0000280561;Note=Ubiquitin carboxyl-terminal hydrolase 45
USP45	Q70EL2	691	720	190	813	Domain	Note=USP
USP45	Q70EL2	691	720	190	813	Domain	Note=USP
USP45	Q70EL2	691	720	290	814	Alternative sequence	ID=VSP_023792;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP45	Q70EL2	691	720	290	814	Alternative sequence	ID=VSP_023792;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP45	Q70EL2	691	720	691	691	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP45	Q70EL2	691	720	691	691	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP4	Q13107	797	846	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	657	733	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	564	627	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	504	532	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	429	504	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	376	429	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	318	376	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	232	278	1	963	Chain	ID=PRO_0000080621;Note=Ubiquitin carboxyl-terminal hydrolase 4
USP4	Q13107	797	846	302	923	Domain	Note=USP
USP4	Q13107	657	733	302	923	Domain	Note=USP
USP4	Q13107	564	627	302	923	Domain	Note=USP
USP4	Q13107	504	532	302	923	Domain	Note=USP
USP4	Q13107	429	504	302	923	Domain	Note=USP
USP4	Q13107	376	429	302	923	Domain	Note=USP
USP4	Q13107	318	376	302	923	Domain	Note=USP
USP4	Q13107	564	627	483	571	Domain	Note=Ubiquitin-like 2
USP4	Q13107	504	532	483	571	Domain	Note=Ubiquitin-like 2
USP4	Q13107	429	504	483	571	Domain	Note=Ubiquitin-like 2
USP4	Q13107	376	429	405	407	Region	Note=Necessary for interaction with RBL2;Ontology_term=ECO:0000250;evidence=ECO:0000250
USP4	Q13107	429	504	459	463	Region	Note=Necessary for interaction with RB1 and RBL2;Ontology_term=ECO:0000250;evidence=ECO:0000250
USP4	Q13107	429	504	461	461	Metal binding	Note=Zinc
USP4	Q13107	429	504	464	464	Metal binding	Note=Zinc
USP4	Q13107	797	846	799	799	Metal binding	Note=Zinc
USP4	Q13107	797	846	802	802	Metal binding	Note=Zinc
USP4	Q13107	657	733	675	675	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35123
USP4	Q13107	657	733	680	680	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35123
USP4	Q13107	232	278	232	279	Alternative sequence	ID=VSP_005258;Note=In isoform 2. KSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRG->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9464533;Dbxref=PMID:9464533
USP4	Q13107	232	278	233	313	Alternative sequence	ID=VSP_044814;Note=In isoform 3. SSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFM->VSFFLPRLECNGAILAHCNFCLPGSSNSPASASRVAPSHLANFFFFEMESHSVTKLECGGAVSAYSRVQVMLLPQPPEWLG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	797	846	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	657	733	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	564	627	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	504	532	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	429	504	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	376	429	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	318	376	314	963	Alternative sequence	ID=VSP_044815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
USP4	Q13107	564	627	620	620	Natural variant	ID=VAR_028180;Note=Y->C;Dbxref=dbSNP:rs9311440
USP4	Q13107	429	504	459	463	Mutagenesis	Note=Reduces the interaction with RB1. LVCPE->AVRPH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11571652;Dbxref=PMID:11571652
USP4	Q13107	429	504	463	463	Mutagenesis	Note=Reduces the interaction with RB1. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11571652;Dbxref=PMID:11571652
USP4	Q13107	318	376	373	373	Sequence conflict	Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
USP4	Q13107	318	376	311	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	318	376	324	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	318	376	335	338	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	318	376	350	362	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	318	376	364	366	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	318	376	368	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	376	429	373	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	318	376	373	382	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	376	429	384	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	376	429	388	390	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	376	429	394	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	429	504	428	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	376	429	428	442	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	429	504	446	451	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	429	504	453	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	429	504	462	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	429	504	467	480	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	797	799	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	800	803	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	804	806	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	809	816	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	819	826	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	828	830	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
USP4	Q13107	797	846	835	837	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y6E
UCHL1	P09936	15	58	1	220	Chain	ID=PRO_0000211055;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L1
UCHL1	P09936	137	153	1	220	Chain	ID=PRO_0000211055;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L1
UCHL1	P09936	15	58	1	220	Chain	ID=PRO_0000211055;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L1
UCHL1	P09936	137	153	1	220	Chain	ID=PRO_0000211055;Note=Ubiquitin carboxyl-terminal hydrolase isozyme L1
UCHL1	P09936	15	58	18	18	Natural variant	ID=VAR_015677;Note=Polymorphism%3B may be associated with reduced risk for sporadic Parkinson disease%3B it confers protection from oxidative stress when expressed at physiological levels in neuroblastoma cells and primary cortical neurons%3B loss of dimerization ability%3B impaired ligase activity. S->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10203348,ECO:0000269|PubMed:11027850,ECO:0000269|PubMed:12408865,ECO:0000269|PubMed:12705903,ECO:0000269|PubMed:15048890,ECO:0000269|PubMed:16450370,ECO:0000269|PubMed:18411255,ECO:0000269|PubMed:21268678;Dbxref=dbSNP:rs5030732,PMID:10203348,PMID:11027850,PMID:12408865,PMID:12705903,PMID:15048890,PMID:16450370,PMID:18411255,PMID:21268678
UCHL1	P09936	15	58	18	18	Natural variant	ID=VAR_015677;Note=Polymorphism%3B may be associated with reduced risk for sporadic Parkinson disease%3B it confers protection from oxidative stress when expressed at physiological levels in neuroblastoma cells and primary cortical neurons%3B loss of dimerization ability%3B impaired ligase activity. S->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10203348,ECO:0000269|PubMed:11027850,ECO:0000269|PubMed:12408865,ECO:0000269|PubMed:12705903,ECO:0000269|PubMed:15048890,ECO:0000269|PubMed:16450370,ECO:0000269|PubMed:18411255,ECO:0000269|PubMed:21268678;Dbxref=dbSNP:rs5030732,PMID:10203348,PMID:11027850,PMID:12408865,PMID:12705903,PMID:15048890,PMID:16450370,PMID:18411255,PMID:21268678
UCHL1	P09936	15	58	10	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	10	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	39	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	39	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	46	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	46	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	57	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	15	58	57	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	137	153	137	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UCHL1	P09936	137	153	137	147	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JKJ
UBXN6	Q9BZV1	104	147	1	441	Chain	ID=PRO_0000211025;Note=UBX domain-containing protein 6
UBR1	Q8IWV7	1586	1611	2	1749	Chain	ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1
UBR1	Q8IWV7	1170	1219	2	1749	Chain	ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1
UBR1	Q8IWV7	980	1009	2	1749	Chain	ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1
UBR1	Q8IWV7	696	730	2	1749	Chain	ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1
UBR1	Q8IWV7	513	556	2	1749	Chain	ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1
UBR1	Q8IWV7	394	427	2	1749	Chain	ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1
UBR1	Q8IWV7	1170	1219	1098	1201	Zinc finger	Note=RING-type%3B atypical
UBR1	Q8IWV7	1170	1219	1179	1179	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17525332;Dbxref=PMID:17525332
UBR1	Q8IWV7	1586	1611	804	1749	Alternative sequence	ID=VSP_015165;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
UBR1	Q8IWV7	1170	1219	804	1749	Alternative sequence	ID=VSP_015165;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
UBR1	Q8IWV7	980	1009	804	1749	Alternative sequence	ID=VSP_015165;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
UBR1	Q8IWV7	394	427	427	427	Natural variant	ID=VAR_075186;Note=In JBS%3B unknown pathological significance. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26149651;Dbxref=PMID:26149651
UBR1	Q8IWV7	696	730	700	700	Natural variant	ID=VAR_075189;Note=In JBS. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22072859,ECO:0000269|PubMed:24599544;Dbxref=PMID:22072859,PMID:24599544
UBR1	Q8IWV7	980	1009	993	993	Sequence conflict	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
UBXN2A	P68543	142	194	1	259	Chain	ID=PRO_0000211031;Note=UBX domain-containing protein 2A
UBXN2A	P68543	142	194	1	259	Chain	ID=PRO_0000211031;Note=UBX domain-containing protein 2A
UBXN2A	P68543	142	194	169	246	Domain	Note=UBX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00215
UBXN2A	P68543	142	194	169	246	Domain	Note=UBX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00215
UBXN2A	P68543	142	194	142	194	Alternative sequence	ID=VSP_056306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UBXN2A	P68543	142	194	142	194	Alternative sequence	ID=VSP_056306;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC25A27	O95847	235	265	1	323	Chain	ID=PRO_0000090676;Note=Mitochondrial uncoupling protein 4
SLC25A27	O95847	235	265	229	248	Transmembrane	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC25A27	O95847	235	265	226	317	Repeat	Note=Solcar 3
SLC25A27	O95847	235	265	236	323	Alternative sequence	ID=VSP_045916;Note=In isoform 2. LCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGVSPF->DLVGSHKAIQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UCKL1	Q9NWZ5	434	470	1	548	Chain	ID=PRO_0000164460;Note=Uridine-cytidine kinase-like 1
UCKL1	Q9NWZ5	393	434	1	548	Chain	ID=PRO_0000164460;Note=Uridine-cytidine kinase-like 1
UCKL1	Q9NWZ5	308	340	1	548	Chain	ID=PRO_0000164460;Note=Uridine-cytidine kinase-like 1
UCKL1	Q9NWZ5	434	470	303	548	Alternative sequence	ID=VSP_021802;Note=In isoform 2. RELSVRAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAVDKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDEEEVAYTG->GCAGLGTPVPPAAPDAERPEEHAAGTGHAHHHQVRAHLGTGRPRARAPAQLLAPQGQGDQSRRVHLLLQETDAAAHRARALLPALSGLRRTDPAGAGLCGQVLCGEADHRCVHSARR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UCKL1	Q9NWZ5	393	434	303	548	Alternative sequence	ID=VSP_021802;Note=In isoform 2. RELSVRAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAVDKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDEEEVAYTG->GCAGLGTPVPPAAPDAERPEEHAAGTGHAHHHQVRAHLGTGRPRARAPAQLLAPQGQGDQSRRVHLLLQETDAAAHRARALLPALSGLRRTDPAGAGLCGQVLCGEADHRCVHSARR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UCKL1	Q9NWZ5	308	340	303	548	Alternative sequence	ID=VSP_021802;Note=In isoform 2. RELSVRAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAVDKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDEEEVAYTG->GCAGLGTPVPPAAPDAERPEEHAAGTGHAHHHQVRAHLGTGRPRARAPAQLLAPQGQGDQSRRVHLLLQETDAAAHRARALLPALSGLRRTDPAGAGLCGQVLCGEADHRCVHSARR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UCKL1	Q9NWZ5	393	434	386	395	Alternative sequence	ID=VSP_025641;Note=In isoform 3. GKCYAGKQIT->DHRCVHSARR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12199906;Dbxref=PMID:12199906
UCKL1	Q9NWZ5	434	470	396	548	Alternative sequence	ID=VSP_025642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12199906;Dbxref=PMID:12199906
UCKL1	Q9NWZ5	393	434	396	548	Alternative sequence	ID=VSP_025642;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12199906;Dbxref=PMID:12199906
UEVLD	Q8IX04	238	295	1	471	Chain	ID=PRO_0000278651;Note=Ubiquitin-conjugating enzyme E2 variant 3
UEVLD	Q8IX04	42	64	1	471	Chain	ID=PRO_0000278651;Note=Ubiquitin-conjugating enzyme E2 variant 3
UEVLD	Q8IX04	42	64	2	145	Domain	Note=UEV;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00652
UEVLD	Q8IX04	42	64	43	64	Alternative sequence	ID=VSP_023347;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
UEVLD	Q8IX04	238	295	216	471	Alternative sequence	ID=VSP_023349;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UEVLD	Q8IX04	238	295	239	295	Alternative sequence	ID=VSP_045987;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UEVLD	Q8IX04	238	295	248	248	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
UEVLD	Q8IX04	238	295	234	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UEVLD	Q8IX04	238	295	240	243	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UEVLD	Q8IX04	238	295	247	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UEVLD	Q8IX04	238	295	262	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UEVLD	Q8IX04	238	295	284	286	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UEVLD	Q8IX04	238	295	288	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UEVLD	Q8IX04	238	295	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2I6T
UHRF2	Q96PU4	51	128	1	802	Chain	ID=PRO_0000056147;Note=E3 ubiquitin-protein ligase UHRF2
UHRF2	Q96PU4	215	287	1	802	Chain	ID=PRO_0000056147;Note=E3 ubiquitin-protein ligase UHRF2
UHRF2	Q96PU4	464	499	1	802	Chain	ID=PRO_0000056147;Note=E3 ubiquitin-protein ligase UHRF2
UHRF2	Q96PU4	51	128	1	78	Domain	Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214
UHRF2	Q96PU4	464	499	448	612	Domain	Note=YDG;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00358
UHRF2	Q96PU4	51	128	117	311	Region	Note=Required for interaction with histone H3;Ontology_term=ECO:0000250;evidence=ECO:0000250
UHRF2	Q96PU4	215	287	117	311	Region	Note=Required for interaction with histone H3;Ontology_term=ECO:0000250;evidence=ECO:0000250
UHRF2	Q96PU4	215	287	194	288	Region	Note=Interaction with PCNP
UHRF2	Q96PU4	464	499	414	644	Region	Note=Methyl-CpG binding and interaction with HDAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15361834;Dbxref=PMID:15361834
UHRF2	Q96PU4	51	128	87	87	Natural variant	ID=VAR_035961;Note=In a colorectal cancer sample%3B somatic mutation. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs147971931,PMID:16959974
UHRF2	Q96PU4	215	287	287	287	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
UHRF2	Q96PU4	51	128	54	57	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WY8
UHRF2	Q96PU4	51	128	58	61	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WY8
UHRF2	Q96PU4	51	128	68	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WY8
UHRF2	Q96PU4	215	287	217	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	222	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	226	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	229	231	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	239	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	247	252	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	262	273	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	275	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	215	287	279	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TVR
UHRF2	Q96PU4	464	499	462	467	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PW7
UHRF2	Q96PU4	464	499	477	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PW7
UHRF2	Q96PU4	464	499	482	484	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PW7
UHRF2	Q96PU4	464	499	485	491	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PW7
ULK1	O75385	82	93	1	1050	Chain	ID=PRO_0000086780;Note=Serine/threonine-protein kinase ULK1
ULK1	O75385	386	415	1	1050	Chain	ID=PRO_0000086780;Note=Serine/threonine-protein kinase ULK1
ULK1	O75385	727	775	1	1050	Chain	ID=PRO_0000086780;Note=Serine/threonine-protein kinase ULK1
ULK1	O75385	82	93	16	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ULK1	O75385	386	415	287	416	Region	Note=Interaction with GABARAP and GABARAPL2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11146101;Dbxref=PMID:11146101
ULK1	O75385	386	415	403	403	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ULK1	O75385	727	775	758	758	Modified residue	Note=Phosphoserine%3B by MTOR;Ontology_term=ECO:0000244,ECO:0000305;evidence=ECO:0000244|PubMed:23186163,ECO:0000305|PubMed:21205641;Dbxref=PMID:23186163,PMID:21205641
ULK1	O75385	727	775	775	775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ULK1	O75385	82	93	78	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WNO
ULK1	O75385	82	93	88	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WNO
ULK2	Q8IYT8	700	750	1	1036	Chain	ID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
ULK2	Q8IYT8	262	278	1	1036	Chain	ID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
ULK2	Q8IYT8	700	750	1	1036	Chain	ID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
ULK2	Q8IYT8	262	278	1	1036	Chain	ID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
ULK2	Q8IYT8	262	278	9	271	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ULK2	Q8IYT8	262	278	9	271	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ULK3	Q6PHR2	429	445	1	472	Chain	ID=PRO_0000250150;Note=Serine/threonine-protein kinase ULK3
ULK3	Q6PHR2	429	445	375	444	Domain	Note=MIT 2
ULK3	Q6PHR2	429	445	215	472	Alternative sequence	ID=VSP_038148;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|Ref.6;Dbxref=PMID:15489334,PMID:17974005
ULK3	Q6PHR2	429	445	444	445	Alternative sequence	ID=VSP_039925;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ULK3	Q6PHR2	429	445	445	445	Natural variant	ID=VAR_059771;Note=K->R;Dbxref=dbSNP:rs12898397
ULK3	Q6PHR2	429	445	421	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WZX
UNC93A	Q86WB7	166	208	1	457	Chain	ID=PRO_0000190036;Note=Protein unc-93 homolog A
UNC93A	Q86WB7	166	208	202	222	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC93A	Q86WB7	166	208	190	190	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC93A	Q86WB7	166	208	167	208	Alternative sequence	ID=VSP_042772;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UNC5A	Q6ZN44	623	673	26	842	Chain	ID=PRO_0000036068;Note=Netrin receptor UNC5A
UNC5A	Q6ZN44	673	728	26	842	Chain	ID=PRO_0000036068;Note=Netrin receptor UNC5A
UNC5A	Q6ZN44	623	673	328	842	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5A	Q6ZN44	673	728	328	842	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC5A	Q6ZN44	623	673	605	623	Region	Note=Interaction with DCC;Ontology_term=ECO:0000250;evidence=ECO:0000250
UNC5A	Q6ZN44	623	673	302	842	Alternative sequence	ID=VSP_011695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UNC5A	Q6ZN44	673	728	302	842	Alternative sequence	ID=VSP_011695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UNC13B	O14795	7	17	1	1591	Chain	ID=PRO_0000188575;Note=Protein unc-13 homolog B
UNC13B	O14795	431	456	1	1591	Chain	ID=PRO_0000188575;Note=Protein unc-13 homolog B
UNC13B	O14795	876	906	1	1591	Chain	ID=PRO_0000188575;Note=Protein unc-13 homolog B
UNC13B	O14795	1095	1143	1	1591	Chain	ID=PRO_0000188575;Note=Protein unc-13 homolog B
UNC13B	O14795	1169	1195	1	1591	Chain	ID=PRO_0000188575;Note=Protein unc-13 homolog B
UNC13B	O14795	1317	1336	1	1591	Chain	ID=PRO_0000188575;Note=Protein unc-13 homolog B
UNC13B	O14795	7	17	1	79	Domain	Note=C2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041
UNC13B	O14795	1095	1143	1013	1156	Domain	Note=MHD1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00587
UNC13B	O14795	1317	1336	1263	1405	Domain	Note=MHD2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00588
UNC13B	O14795	1169	1195	1172	1202	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
UNC13B	O14795	7	17	16	16	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
UPK1B	O75841	216	244	1	260	Chain	ID=PRO_0000219289;Note=Uroplakin-1b
UPK1B	O75841	216	244	108	229	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
UPK1B	O75841	216	244	230	250	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
URB2	Q14146	1265	1302	1	1524	Chain	ID=PRO_0000050720;Note=Unhealthy ribosome biogenesis protein 2 homolog
USO1	O60763	846	918	1	962	Chain	ID=PRO_0000065774;Note=General vesicular transport factor p115
USO1	O60763	846	918	638	930	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
USO1	O60763	846	918	877	877	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
UTRN	P46939	1169	1229	1	3433	Chain	ID=PRO_0000076082;Note=Utrophin
UTRN	P46939	1748	1801	1	3433	Chain	ID=PRO_0000076082;Note=Utrophin
UTRN	P46939	2123	2173	1	3433	Chain	ID=PRO_0000076082;Note=Utrophin
UTRN	P46939	3165	3177	1	3433	Chain	ID=PRO_0000076082;Note=Utrophin
UTRN	P46939	3178	3199	1	3433	Chain	ID=PRO_0000076082;Note=Utrophin
UTRN	P46939	3392	3423	1	3433	Chain	ID=PRO_0000076082;Note=Utrophin
UTRN	P46939	1169	1229	1128	1229	Repeat	Note=Spectrin 8;Ontology_term=ECO:0000255;evidence=ECO:0000255
UTRN	P46939	1748	1801	1748	1848	Repeat	Note=Spectrin 14;Ontology_term=ECO:0000255;evidence=ECO:0000255
UTRN	P46939	2123	2173	2087	2186	Repeat	Note=Spectrin 17;Ontology_term=ECO:0000255;evidence=ECO:0000255
UTRN	P46939	1748	1801	1336	1768	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16777071;Dbxref=PMID:16777071
UTRN	P46939	3165	3177	2798	3165	Region	Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16777071;Dbxref=PMID:16777071
UTRN	P46939	1169	1229	1	2086	Alternative sequence	ID=VSP_054942;Note=In isoform Up140. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10369873;Dbxref=PMID:10369873
UTRN	P46939	1748	1801	1	2086	Alternative sequence	ID=VSP_054942;Note=In isoform Up140. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10369873;Dbxref=PMID:10369873
UTRN	P46939	1169	1229	24	2832	Alternative sequence	ID=VSP_054944;Note=In isoform Up71. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10369873;Dbxref=PMID:10369873
UTRN	P46939	1748	1801	24	2832	Alternative sequence	ID=VSP_054944;Note=In isoform Up71. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10369873;Dbxref=PMID:10369873
UTRN	P46939	2123	2173	24	2832	Alternative sequence	ID=VSP_054944;Note=In isoform Up71. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10369873;Dbxref=PMID:10369873
VAMP8	Q9BV40	1	54	1	100	Chain	ID=PRO_0000206736;Note=Vesicle-associated membrane protein 8
VAMP8	Q9BV40	1	54	1	75	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VAMP8	Q9BV40	1	54	12	72	Domain	Note=v-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00290
VAMP8	Q9BV40	1	54	33	33	Site	Note=Interaction with STX8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUF4
VAMP8	Q9BV40	1	54	1	1	Modified residue	Note=N-acetylmethionine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:25944712;Dbxref=PMID:19413330,PMID:25944712
VAMP8	Q9BV40	1	54	5	5	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAMP8	Q9BV40	1	54	18	18	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAMP8	Q9BV40	1	54	28	28	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAMP8	Q9BV40	1	54	48	48	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAMP8	Q9BV40	1	54	54	54	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAMP8	Q9BV40	1	54	12	12	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
VAMP8	Q9BV40	1	54	12	72	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WY4
PPIP5K2	O43314	496	538	1	1243	Chain	ID=PRO_0000315692;Note=Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
PPIP5K2	O43314	974	1032	1	1243	Chain	ID=PRO_0000315692;Note=Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
PPIP5K2	O43314	1056	1096	1	1243	Chain	ID=PRO_0000315692;Note=Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
PPIP5K2	O43314	1096	1117	1	1243	Chain	ID=PRO_0000315692;Note=Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
PPIP5K2	O43314	974	1032	1006	1006	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
PPIP5K2	O43314	974	1032	1016	1016	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
PPIP5K2	O43314	1056	1096	1074	1074	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPIP5K2	O43314	1056	1096	1091	1091	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
PPIP5K2	O43314	1096	1117	1097	1117	Alternative sequence	ID=VSP_030636;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PPIP5K2	O43314	974	1032	985	985	Natural variant	ID=VAR_038277;Note=E->K;Dbxref=dbSNP:rs12519525
PPIP5K2	O43314	974	1032	1003	1003	Natural variant	ID=VAR_038278;Note=R->K;Dbxref=dbSNP:rs12520040
SORBS3	O60504	159	172	1	671	Chain	ID=PRO_0000065830;Note=Vinexin
SORBS3	O60504	477	581	1	671	Chain	ID=PRO_0000065830;Note=Vinexin
SORBS3	O60504	159	172	115	187	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00195
SORBS3	O60504	477	581	454	515	Domain	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
SORBS3	O60504	477	581	380	515	Region	Note=Binds to vinculin
SORBS3	O60504	477	581	530	530	Modified residue	Note=Phosphoserine%3B by MAPK1;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569
SORBS3	O60504	477	581	544	544	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
SORBS3	O60504	477	581	545	545	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
SORBS3	O60504	477	581	547	547	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
SORBS3	O60504	477	581	551	551	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569
SORBS3	O60504	477	581	563	563	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
SORBS3	O60504	159	172	1	342	Alternative sequence	ID=VSP_004489;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9885244;Dbxref=PMID:15489334,PMID:9885244
SORBS3	O60504	477	581	556	556	Natural variant	ID=VAR_055019;Note=I->T;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16421571,ECO:0000269|PubMed:9885244,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2449331,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19413330,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569,PMID:15489334,PMID:16421571,PMID:9885244
SORBS3	O60504	477	581	573	573	Natural variant	ID=VAR_055020;Note=T->A;Dbxref=dbSNP:rs1047030
SORBS3	O60504	477	581	480	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUP
SORBS3	O60504	477	581	489	495	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUP
SORBS3	O60504	477	581	497	499	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUP
SORBS3	O60504	477	581	502	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUP
SORBS3	O60504	477	581	507	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUP
SORBS3	O60504	477	581	510	514	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YUP
VMP1	Q96GC9	101	138	2	406	Chain	ID=PRO_0000284546;Note=Vacuole membrane protein 1
VMP1	Q96GC9	138	194	2	406	Chain	ID=PRO_0000284546;Note=Vacuole membrane protein 1
VMP1	Q96GC9	194	238	2	406	Chain	ID=PRO_0000284546;Note=Vacuole membrane protein 1
VMP1	Q96GC9	238	265	2	406	Chain	ID=PRO_0000284546;Note=Vacuole membrane protein 1
VMP1	Q96GC9	265	304	2	406	Chain	ID=PRO_0000284546;Note=Vacuole membrane protein 1
VMP1	Q96GC9	101	138	99	109	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	101	138	110	130	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	101	138	131	250	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	138	194	131	250	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	194	238	131	250	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	238	265	131	250	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	238	265	251	271	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	265	304	251	271	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	265	304	272	273	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	265	304	274	294	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	265	304	295	305	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VMP1	Q96GC9	138	194	173	316	Region	Note=VTT domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30093494;Dbxref=PMID:30093494
VMP1	Q96GC9	194	238	173	316	Region	Note=VTT domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30093494;Dbxref=PMID:30093494
VMP1	Q96GC9	238	265	173	316	Region	Note=VTT domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30093494;Dbxref=PMID:30093494
VMP1	Q96GC9	265	304	173	316	Region	Note=VTT domain;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30093494;Dbxref=PMID:30093494
VMP1	Q96GC9	101	138	1	192	Alternative sequence	ID=VSP_056106;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VMP1	Q96GC9	138	194	1	192	Alternative sequence	ID=VSP_056106;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VMP1	Q96GC9	138	194	179	179	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
VMP1	Q96GC9	138	194	179	179	Sequence conflict	Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP6V0A2	Q9Y487	645	685	1	856	Chain	ID=PRO_0000119216;Note=V-type proton ATPase 116 kDa subunit a isoform 2
ATP6V0A2	Q9Y487	645	685	609	651	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A2	Q9Y487	645	685	652	671	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A2	Q9Y487	645	685	672	739	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A2	Q9Y487	645	685	685	685	Natural variant	ID=VAR_042730;Note=R->Q;Dbxref=dbSNP:rs7969410
ATP6V0A2	Q9Y487	645	685	669	669	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS16	Q9H269	80	123	1	839	Chain	ID=PRO_0000065888;Note=Vacuolar protein sorting-associated protein 16 homolog
VPS16	Q9H269	357	401	1	839	Chain	ID=PRO_0000065888;Note=Vacuolar protein sorting-associated protein 16 homolog
VPS16	Q9H269	357	401	300	443	Alternative sequence	ID=VSP_004018;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VPS16	Q9H269	80	123	87	87	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
VSTM4	Q8IW00	152	175	24	320	Chain	ID=PRO_0000274483;Note=V-set and transmembrane domain-containing protein 4
VSTM4	Q8IW00	152	175	24	180	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSTM4	Q8IW00	152	175	24	155	Domain	Note=Ig-like
VSTM4	Q8IW00	152	175	153	191	Alternative sequence	ID=VSP_022766;Note=In isoform 2. VISLKASEESSFEKTKETWAFFEDLYVYAVLVCCVGILS->GVSSHPVERGAFLGISLVILPHSLPFTADLTMASFLQSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VTN	P04004	21	61	20	478	Chain	ID=PRO_0000036394;Note=Vitronectin
VTN	P04004	21	61	20	398	Chain	ID=PRO_0000036395;Note=Vitronectin V65 subunit
VTN	P04004	21	61	20	63	Peptide	ID=PRO_0000036396;Note=Somatomedin-B
VTN	P04004	21	61	20	63	Domain	Note=SMB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
VTN	P04004	21	61	24	40	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
VTN	P04004	21	61	24	28	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00350,ECO:0000269|PubMed:12019263;Dbxref=PMID:12019263
VTN	P04004	21	61	28	58	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
VTN	P04004	21	61	38	51	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00350
VTN	P04004	21	61	38	40	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00350,ECO:0000269|PubMed:12019263;Dbxref=PMID:12019263
VTN	P04004	21	61	44	50	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00350,ECO:0000269|PubMed:12019263;Dbxref=PMID:12019263
VTN	P04004	21	61	51	58	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00350,ECO:0000269|PubMed:12019263;Dbxref=PMID:12019263
VTN	P04004	21	61	50	50	Sequence conflict	Note=C->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
VTN	P04004	21	61	22	24	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S4G
VTN	P04004	21	61	25	29	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SSU
VTN	P04004	21	61	32	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S4G
VTN	P04004	21	61	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OC0
VTN	P04004	21	61	44	47	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OC0
VTN	P04004	21	61	51	53	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S4G
VTN	P04004	21	61	54	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1OC0
VWA5B1	Q5TIE3	322	381	19	1220	Chain	ID=PRO_0000326173;Note=von Willebrand factor A domain-containing protein 5B1
VWA5B1	Q5TIE3	381	418	19	1220	Chain	ID=PRO_0000326173;Note=von Willebrand factor A domain-containing protein 5B1
VWA5B1	Q5TIE3	322	381	361	529	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
VWA5B1	Q5TIE3	381	418	361	529	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
WBP1L	Q9NX94	43	97	1	342	Chain	ID=PRO_0000241450;Note=WW domain binding protein 1-like
WBP1L	Q9NX94	43	97	42	62	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
WBP1L	Q9NX94	43	97	90	90	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR26	Q9H7D7	591	653	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
WDR26	Q9H7D7	433	473	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
WDR26	Q9H7D7	386	433	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
WDR26	Q9H7D7	386	433	353	392	Repeat	Note=WD 1
WDR26	Q9H7D7	433	473	399	438	Repeat	Note=WD 2
WDR26	Q9H7D7	386	433	399	438	Repeat	Note=WD 2
WDR26	Q9H7D7	433	473	444	484	Repeat	Note=WD 3
WDR26	Q9H7D7	591	653	566	608	Repeat	Note=WD 5
WDR26	Q9H7D7	591	653	611	651	Repeat	Note=WD 6
WDR26	Q9H7D7	591	653	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR26	Q9H7D7	433	473	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR26	Q9H7D7	386	433	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR26	Q9H7D7	591	653	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
WDR26	Q9H7D7	433	473	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
WDR26	Q9H7D7	386	433	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6
WDR26	Q9H7D7	591	653	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	433	473	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	386	433	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	591	653	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	433	473	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	386	433	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	591	653	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	433	473	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	386	433	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	591	653	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	433	473	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	386	433	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR26	Q9H7D7	591	653	524	661	Natural variant	ID=VAR_079305;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28686853;Dbxref=PMID:28686853
WDR74	Q6RFH5	307	326	1	385	Chain	ID=PRO_0000051428;Note=WD repeat-containing protein 74
WDR74	Q6RFH5	307	326	1	385	Chain	ID=PRO_0000051428;Note=WD repeat-containing protein 74
WDR74	Q6RFH5	307	326	1	385	Chain	ID=PRO_0000051428;Note=WD repeat-containing protein 74
WDR74	Q6RFH5	307	326	320	385	Region	Note=Required for nucleolar and nuclear location;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28416111;Dbxref=PMID:28416111
WDR74	Q6RFH5	307	326	320	385	Region	Note=Required for nucleolar and nuclear location;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28416111;Dbxref=PMID:28416111
WDR74	Q6RFH5	307	326	320	385	Region	Note=Required for nucleolar and nuclear location;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28416111;Dbxref=PMID:28416111
WDR74	Q6RFH5	307	326	311	311	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
WDR74	Q6RFH5	307	326	311	311	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
WDR74	Q6RFH5	307	326	311	311	Modified residue	Note=N6-methyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
WDR74	Q6RFH5	307	326	308	326	Alternative sequence	ID=VSP_011957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR74	Q6RFH5	307	326	308	326	Alternative sequence	ID=VSP_011957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR74	Q6RFH5	307	326	308	326	Alternative sequence	ID=VSP_011957;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UMOD	P07911	444	525	25	614	Chain	ID=PRO_0000041671;Note=Uromodulin
UMOD	P07911	444	525	25	614	Chain	ID=PRO_0000041671;Note=Uromodulin
UMOD	P07911	444	525	25	587	Chain	ID=PRO_0000407909;Note=Uromodulin%2C secreted form
UMOD	P07911	444	525	25	587	Chain	ID=PRO_0000407909;Note=Uromodulin%2C secreted form
UMOD	P07911	444	525	334	589	Domain	Note=ZP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00375
UMOD	P07911	444	525	334	589	Domain	Note=ZP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00375
UMOD	P07911	444	525	430	453	Region	Note=Important for secretion and polymerization into filaments;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26811476;Dbxref=PMID:26811476
UMOD	P07911	444	525	430	453	Region	Note=Important for secretion and polymerization into filaments;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26811476;Dbxref=PMID:26811476
UMOD	P07911	444	525	506	566	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:26811476;Dbxref=PMID:26811476
UMOD	P07911	444	525	506	566	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:26811476;Dbxref=PMID:26811476
UMOD	P07911	444	525	458	458	Natural variant	ID=VAR_061993;Note=V->L;Dbxref=dbSNP:rs55772253
UMOD	P07911	444	525	458	458	Natural variant	ID=VAR_061993;Note=V->L;Dbxref=dbSNP:rs55772253
UMOD	P07911	444	525	461	461	Natural variant	ID=VAR_071401;Note=In HNFJ1. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21060763;Dbxref=PMID:21060763
UMOD	P07911	444	525	461	461	Natural variant	ID=VAR_071401;Note=In HNFJ1. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21060763;Dbxref=PMID:21060763
UMOD	P07911	444	525	458	458	Mutagenesis	Note=Leads to retention in the endoplasmic reticulum%2C probably due to misfolding. V->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19005207;Dbxref=PMID:19005207
UMOD	P07911	444	525	458	458	Mutagenesis	Note=Leads to retention in the endoplasmic reticulum%2C probably due to misfolding. V->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19005207;Dbxref=PMID:19005207
UMOD	P07911	444	525	503	503	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
UMOD	P07911	444	525	503	503	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
UMOD	P07911	444	525	443	450	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	443	450	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	451	453	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	451	453	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	454	465	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	454	465	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	473	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	473	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	477	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	477	479	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	485	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	485	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	496	498	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	496	498	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	499	512	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	499	512	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	520	524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
UMOD	P07911	444	525	520	524	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WRN
VLDLR	P98155	108	149	28	873	Chain	ID=PRO_0000017343;Note=Very low-density lipoprotein receptor
VLDLR	P98155	355	395	28	873	Chain	ID=PRO_0000017343;Note=Very low-density lipoprotein receptor
VLDLR	P98155	495	567	28	873	Chain	ID=PRO_0000017343;Note=Very low-density lipoprotein receptor
VLDLR	P98155	750	778	28	873	Chain	ID=PRO_0000017343;Note=Very low-density lipoprotein receptor
VLDLR	P98155	108	149	28	797	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VLDLR	P98155	355	395	28	797	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VLDLR	P98155	495	567	28	797	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VLDLR	P98155	750	778	28	797	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VLDLR	P98155	108	149	70	110	Domain	Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
VLDLR	P98155	108	149	111	151	Domain	Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
VLDLR	P98155	355	395	316	355	Domain	Note=LDL-receptor class A 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124
VLDLR	P98155	355	395	356	395	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VLDLR	P98155	495	567	481	524	Repeat	Note=LDL-receptor class B 2
VLDLR	P98155	495	567	525	567	Repeat	Note=LDL-receptor class B 3
VLDLR	P98155	750	778	702	750	Domain	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
VLDLR	P98155	750	778	751	790	Region	Note=Clustered O-linked oligosaccharides
VLDLR	P98155	750	778	765	765	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VLDLR	P98155	108	149	91	108	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VLDLR	P98155	108	149	113	127	Disulfide bond	.
VLDLR	P98155	108	149	120	140	Disulfide bond	.
VLDLR	P98155	108	149	134	149	Disulfide bond	.
VLDLR	P98155	355	395	338	355	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VLDLR	P98155	355	395	360	371	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VLDLR	P98155	355	395	367	380	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VLDLR	P98155	355	395	382	394	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
VLDLR	P98155	750	778	751	779	Alternative sequence	ID=VSP_004304;Note=In isoform Short. STATTVTYSETKDTNTTEISATSGLVPGG->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
VLDLR	P98155	355	395	379	379	Natural variant	ID=VAR_011866;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391209;Dbxref=dbSNP:rs6146,PMID:10391209
VLDLR	P98155	495	567	561	561	Natural variant	ID=VAR_025065;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs35724190
VLDLR	P98155	750	778	766	766	Sequence conflict	Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
VLDLR	P98155	108	149	115	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPR
VLDLR	P98155	108	149	121	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPR
VLDLR	P98155	108	149	132	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPR
VLDLR	P98155	108	149	141	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DPR
VPS37A	Q8NEZ2	323	371	1	397	Chain	ID=PRO_0000287198;Note=Vacuolar protein sorting-associated protein 37A
VPS37A	Q8NEZ2	323	371	308	397	Domain	Note=VPS37 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00646
VPS37A	Q8NEZ2	323	371	186	397	Alternative sequence	ID=VSP_025369;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
VPS37A	Q8NEZ2	323	371	324	324	Sequence conflict	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS33B	Q9H267	284	313	2	617	Chain	ID=PRO_0000206305;Note=Vacuolar protein sorting-associated protein 33B
VPS33B	Q9H267	233	259	2	617	Chain	ID=PRO_0000206305;Note=Vacuolar protein sorting-associated protein 33B
VPS33B	Q9H267	233	259	243	243	Natural variant	ID=VAR_057901;Note=In ARCS1%3B no effect on interaction with VIPAS39%3B impairs localization to VIPAS39-containing endosomal compartment. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18853461,ECO:0000269|PubMed:23918659;Dbxref=dbSNP:rs139829189,PMID:18853461,PMID:23918659
VPS33B	Q9H267	233	259	232	234	Mutagenesis	Note=Disrupts interaction with VIPAS39. DRD->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918659;Dbxref=PMID:23918659
VPS33B	Q9H267	233	259	234	234	Mutagenesis	Note=No effect on interaction with VIPAS39%3B no effect on interaction with STX7 and association with the HOPS complex%3B impairs localization to VIPAS39-containing endosomal compartment. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918659;Dbxref=PMID:23918659
VPS33B	Q9H267	233	259	235	237	Mutagenesis	Note=Disrupts interaction with VIPAS39. VDF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918659;Dbxref=PMID:23918659
VPS33B	Q9H267	233	259	249	249	Mutagenesis	Note=Disrupts interaction with VIPAS39%3B no effect on interaction with STX7%3B impairs localization to VIPAS39-containing endosomal compartment. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918659;Dbxref=PMID:23918659
VPS33B	Q9H267	233	259	251	253	Mutagenesis	Note=Disrupts interaction with VIPAS39. VDD->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918659;Dbxref=PMID:23918659
VPS33B	Q9H267	233	259	252	252	Mutagenesis	Note=No effect on interaction with VIPAS39 and STX7%3B impairs localization to VIPAS39-containing endosomal compartment. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23918659;Dbxref=PMID:23918659
VPS33B	Q9H267	284	313	293	293	Sequence conflict	Note=H->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
WDR62	O43379	547	589	2	1518	Chain	ID=PRO_0000281879;Note=WD repeat-containing protein 62
WDR62	O43379	737	777	2	1518	Chain	ID=PRO_0000281879;Note=WD repeat-containing protein 62
WDR62	O43379	990	1027	2	1518	Chain	ID=PRO_0000281879;Note=WD repeat-containing protein 62
WDR62	O43379	547	589	532	574	Repeat	Note=WD 8
WDR62	O43379	547	589	578	618	Repeat	Note=WD 9
WDR62	O43379	737	777	714	752	Repeat	Note=WD 12
WDR62	O43379	547	589	415	1518	Alternative sequence	ID=VSP_024078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR62	O43379	737	777	415	1518	Alternative sequence	ID=VSP_024078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR62	O43379	990	1027	415	1518	Alternative sequence	ID=VSP_024078;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
WDR62	O43379	547	589	484	1518	Alternative sequence	ID=VSP_024080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WDR62	O43379	737	777	484	1518	Alternative sequence	ID=VSP_024080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WDR62	O43379	990	1027	484	1518	Alternative sequence	ID=VSP_024080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WFS1	O76024	210	237	1	890	Chain	ID=PRO_0000065963;Note=Wolframin
WFS1	O76024	210	237	1	890	Chain	ID=PRO_0000065963;Note=Wolframin
WFDC3	Q8IUB2	119	164	25	231	Chain	ID=PRO_0000041381;Note=WAP four-disulfide core domain protein 3
WFDC3	Q8IUB2	70	119	25	231	Chain	ID=PRO_0000041381;Note=WAP four-disulfide core domain protein 3
WFDC3	Q8IUB2	27	70	25	231	Chain	ID=PRO_0000041381;Note=WAP four-disulfide core domain protein 3
WFDC3	Q8IUB2	27	70	26	68	Domain	Note=WAP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	69	114	Domain	Note=WAP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	27	70	69	114	Domain	Note=WAP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	119	164	119	162	Domain	Note=WAP 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	119	162	Domain	Note=WAP 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	119	164	163	207	Domain	Note=WAP 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	107	107	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
WFDC3	Q8IUB2	27	70	33	57	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	27	70	40	61	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	27	70	44	56	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	27	70	50	65	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	76	102	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	85	106	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	89	101	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	70	119	95	110	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	119	164	126	150	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	119	164	133	154	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	119	164	137	149	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	119	164	143	158	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00722
WFDC3	Q8IUB2	27	70	36	36	Natural variant	ID=VAR_052951;Note=H->D;Dbxref=dbSNP:rs6032538
WFDC3	Q8IUB2	27	70	26	28	Sequence conflict	Note=EHA->RPS;Ontology_term=ECO:0000305;evidence=ECO:0000305
WISP2	O76076	92	177	24	250	Chain	ID=PRO_0000014409;Note=WNT1-inducible-signaling pathway protein 2
WISP2	O76076	92	177	24	250	Chain	ID=PRO_0000014409;Note=WNT1-inducible-signaling pathway protein 2
WISP2	O76076	92	177	24	94	Domain	Note=IGFBP N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00653
WISP2	O76076	92	177	24	94	Domain	Note=IGFBP N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00653
WISP2	O76076	92	177	98	164	Domain	Note=VWFC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
WISP2	O76076	92	177	98	164	Domain	Note=VWFC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
WISP2	O76076	92	177	93	218	Alternative sequence	ID=VSP_056298;Note=In isoform 2. LAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSN->CKQDPSFLALSLPCPLVSPAQNGARPGDPARPPVGWAWPPGCPTRTASADWRPSAACACPGPAHPPGVAVHKTVPSRAGLGMGTRCPPSPAGGPVPGPWADGRWSVPRPLAAGNTLAWVHHAEHQY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WISP2	O76076	92	177	93	218	Alternative sequence	ID=VSP_056298;Note=In isoform 2. LAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSN->CKQDPSFLALSLPCPLVSPAQNGARPGDPARPPVGWAWPPGCPTRTASADWRPSAACACPGPAHPPGVAVHKTVPSRAGLGMGTRCPPSPAGGPVPGPWADGRWSVPRPLAAGNTLAWVHHAEHQY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WIPF1	O43516	376	447	1	503	Chain	ID=PRO_0000065941;Note=WAS/WASL-interacting protein family member 1
WIPF1	O43516	60	119	1	503	Chain	ID=PRO_0000065941;Note=WAS/WASL-interacting protein family member 1
WIPF1	O43516	376	447	1	503	Chain	ID=PRO_0000065941;Note=WAS/WASL-interacting protein family member 1
WIPF1	O43516	60	119	1	503	Chain	ID=PRO_0000065941;Note=WAS/WASL-interacting protein family member 1
WIPF1	O43516	376	447	1	503	Chain	ID=PRO_0000065941;Note=WAS/WASL-interacting protein family member 1
WIPF1	O43516	60	119	1	503	Chain	ID=PRO_0000065941;Note=WAS/WASL-interacting protein family member 1
WIPF1	O43516	376	447	374	383	Repeat	Note=XRSGPXPPXP motif 2
WIPF1	O43516	376	447	374	383	Repeat	Note=XRSGPXPPXP motif 2
WIPF1	O43516	376	447	374	383	Repeat	Note=XRSGPXPPXP motif 2
WIPF1	O43516	376	447	410	419	Repeat	Note=XRSGPXPPXP motif 3
WIPF1	O43516	376	447	410	419	Repeat	Note=XRSGPXPPXP motif 3
WIPF1	O43516	376	447	410	419	Repeat	Note=XRSGPXPPXP motif 3
WIPF1	O43516	60	119	64	96	Compositional bias	Note=Gly-rich
WIPF1	O43516	60	119	64	96	Compositional bias	Note=Gly-rich
WIPF1	O43516	60	119	64	96	Compositional bias	Note=Gly-rich
WIPF1	O43516	376	447	264	433	Compositional bias	Note=Pro-rich
WIPF1	O43516	376	447	264	433	Compositional bias	Note=Pro-rich
WIPF1	O43516	376	447	264	433	Compositional bias	Note=Pro-rich
WIPF1	O43516	60	119	119	119	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
WIPF1	O43516	60	119	119	119	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
WIPF1	O43516	60	119	119	119	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
WIPI1	Q5MNZ9	322	357	1	446	Chain	ID=PRO_0000051437;Note=WD repeat domain phosphoinositide-interacting protein 1
WIPI1	Q5MNZ9	267	321	1	446	Chain	ID=PRO_0000051437;Note=WD repeat domain phosphoinositide-interacting protein 1
WIPI1	Q5MNZ9	322	357	304	343	Repeat	Note=WD 7
WIPI1	Q5MNZ9	267	321	304	343	Repeat	Note=WD 7
WIPI1	Q5MNZ9	267	321	308	308	Natural variant	ID=VAR_053439;Note=R->H;Dbxref=dbSNP:rs36084378
WDR45	Q9Y484	43	78	1	360	Chain	ID=PRO_0000051452;Note=WD repeat domain phosphoinositide-interacting protein 4
WDR45	Q9Y484	43	78	40	84	Repeat	Note=WD 2
WDR45	Q9Y484	43	78	78	78	Alternative sequence	ID=VSP_016975;Note=In isoform 3. S->SA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
WDR45	Q9Y484	43	78	7	360	Natural variant	ID=VAR_078645;Note=In NBIA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25356899;Dbxref=PMID:25356899
WLS	Q5T9L3	35	126	1	42	Signal peptide	Ontology_term=ECO:0000255;evidence=ECO:0000255
WLS	Q5T9L3	35	126	43	541	Chain	ID=PRO_0000271777;Note=Protein wntless homolog
WLS	Q5T9L3	35	126	43	232	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
WLS	Q5T9L3	35	126	101	232	Region	Note=Interaction with Wnt proteins;Ontology_term=ECO:0000250;evidence=ECO:0000250
WLS	Q5T9L3	35	126	36	127	Alternative sequence	ID=VSP_046143;Note=In isoform 3. APGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WLS	Q5T9L3	35	126	36	37	Alternative sequence	ID=VSP_022346;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
WISP1	O95388	116	203	23	367	Chain	ID=PRO_0000014406;Note=WNT1-inducible-signaling pathway protein 1
WISP1	O95388	116	203	40	118	Domain	Note=IGFBP N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00653
WISP1	O95388	116	203	121	186	Domain	Note=VWFC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00220
WISP1	O95388	116	203	143	143	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
WISP1	O95388	116	203	24	268	Alternative sequence	ID=VSP_042010;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
WISP1	O95388	116	203	32	203	Alternative sequence	ID=VSP_047707;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
WISP1	O95388	116	203	117	155	Alternative sequence	ID=VSP_045958;Note=In isoform 4. QVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTP->RREEVSGCVPARGIHELHTCGLHQHTLLSTQVLWSLHGQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
WISP1	O95388	116	203	117	117	Alternative sequence	ID=VSP_008008;Note=In isoform 2. Q->H;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11571650;Dbxref=PMID:11571650
WISP1	O95388	116	203	118	204	Alternative sequence	ID=VSP_008009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11571650;Dbxref=PMID:11571650
WISP1	O95388	116	203	156	367	Alternative sequence	ID=VSP_045959;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
WNK4	Q96J92	719	765	1	1243	Chain	ID=PRO_0000086824;Note=Serine/threonine-protein kinase WNK4
UTP20	O75691	665	718	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UTP20	O75691	1139	1187	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UTP20	O75691	1535	1582	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UTP20	O75691	2089	2128	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UTP20	O75691	2128	2185	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UTP20	O75691	2229	2266	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UTP20	O75691	2528	2552	1	2785	Chain	ID=PRO_0000080011;Note=Small subunit processome component 20 homolog
UXS1	Q8NBZ7	187	207	1	420	Chain	ID=PRO_0000183269;Note=UDP-glucuronic acid decarboxylase 1
UXS1	Q8NBZ7	152	187	1	420	Chain	ID=PRO_0000183269;Note=UDP-glucuronic acid decarboxylase 1
UXS1	Q8NBZ7	187	207	41	420	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
UXS1	Q8NBZ7	152	187	41	420	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
UXS1	Q8NBZ7	152	187	1	168	Alternative sequence	ID=VSP_016756;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
UXS1	Q8NBZ7	152	187	154	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B69
UXS1	Q8NBZ7	152	187	165	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B69
UXS1	Q8NBZ7	187	207	172	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B69
UXS1	Q8NBZ7	152	187	172	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B69
UXS1	Q8NBZ7	187	207	196	202	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B69
UXS1	Q8NBZ7	187	207	203	206	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B69
ATP6V0D2	Q8N8Y2	187	213	1	350	Chain	ID=PRO_0000285657;Note=V-type proton ATPase subunit d 2
ATP6AP1	Q15904	96	121	42	470	Chain	ID=PRO_0000002543;Note=V-type proton ATPase subunit S1
ATP6AP1	Q15904	308	323	42	470	Chain	ID=PRO_0000002543;Note=V-type proton ATPase subunit S1
ATP6AP1	Q15904	96	121	42	419	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6AP1	Q15904	308	323	42	419	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6AP1	Q15904	308	323	313	313	Natural variant	ID=VAR_077022;Note=In IMD47%3B probable loss of proton-transporting V-type ATPase complex assembly in yeast%3B unable to restore V-ATPase-dependent growth in Voa1 mutant yeast. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27231034;Dbxref=dbSNP:rs878853278,PMID:27231034
VAV1	P15498	127	149	1	845	Chain	ID=PRO_0000080980;Note=Proto-oncogene vav
VAV1	P15498	186	218	1	845	Chain	ID=PRO_0000080980;Note=Proto-oncogene vav
VAV1	P15498	638	660	1	845	Chain	ID=PRO_0000080980;Note=Proto-oncogene vav
VAV1	P15498	671	709	1	845	Chain	ID=PRO_0000080980;Note=Proto-oncogene vav
VAV1	P15498	186	218	194	373	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062
VAV1	P15498	638	660	592	660	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
VAV1	P15498	671	709	671	765	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
VAV1	P15498	186	218	187	218	Alternative sequence	ID=VSP_047563;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VAV1	P15498	671	709	696	696	Mutagenesis	Note=Loss of interaction with SYK. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8986718;Dbxref=PMID:8986718
VAV1	P15498	127	149	145	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KY9
VAV1	P15498	186	218	191	218	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJI
VAV1	P15498	671	709	669	672	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRH
VAV1	P15498	671	709	678	684	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRH
VAV1	P15498	671	709	685	687	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRH
VAV1	P15498	671	709	692	696	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRH
VAV1	P15498	671	709	700	702	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCT
VAV1	P15498	671	709	706	711	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CRH
VDAC1	P21796	108	183	2	283	Chain	ID=PRO_0000050499;Note=Voltage-dependent anion-selective channel protein 1
VDAC1	P21796	108	183	2	283	Chain	ID=PRO_0000050499;Note=Voltage-dependent anion-selective channel protein 1
VDAC1	P21796	108	183	2	283	Chain	ID=PRO_0000050499;Note=Voltage-dependent anion-selective channel protein 1
VDAC1	P21796	108	183	111	120	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	111	120	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	111	120	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	123	130	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	123	130	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	123	130	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	137	145	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	137	145	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	137	145	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	150	158	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	150	158	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	150	158	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	163	175	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	163	175	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	163	175	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	178	185	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	178	185	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	178	185	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18755977,ECO:0000269|PubMed:18832158;Dbxref=PMID:18755977,PMID:18832158
VDAC1	P21796	108	183	109	109	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60932
VDAC1	P21796	108	183	109	109	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60932
VDAC1	P21796	108	183	109	109	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60932
VDAC1	P21796	108	183	109	109	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	109	109	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	109	109	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	110	110	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	110	110	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	110	110	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	161	161	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	161	161	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	161	161	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC1	P21796	108	183	112	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	112	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	112	119	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	121	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	121	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	121	130	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JDP
VDAC1	P21796	108	183	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JDP
VDAC1	P21796	108	183	132	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JDP
VDAC1	P21796	108	183	137	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	137	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	137	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	149	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	149	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	149	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	159	162	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	159	162	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	159	162	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	163	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	163	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	163	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	176	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	176	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
VDAC1	P21796	108	183	176	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XDO
ATP6V0A4	Q9HBG4	636	670	1	840	Chain	ID=PRO_0000119219;Note=V-type proton ATPase 116 kDa subunit a isoform 4
ATP6V0A4	Q9HBG4	636	670	1	840	Chain	ID=PRO_0000119219;Note=V-type proton ATPase 116 kDa subunit a isoform 4
ATP6V0A4	Q9HBG4	636	670	1	840	Chain	ID=PRO_0000119219;Note=V-type proton ATPase 116 kDa subunit a isoform 4
ATP6V0A4	Q9HBG4	636	670	598	642	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	598	642	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	598	642	Topological domain	Note=Vacuolar;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	643	662	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	643	662	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	643	662	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	663	727	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	663	727	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A4	Q9HBG4	636	670	663	727	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VPS41	P49754	786	801	1	854	Chain	ID=PRO_0000212823;Note=Vacuolar protein sorting-associated protein 41 homolog
VPS41	P49754	376	395	1	854	Chain	ID=PRO_0000212823;Note=Vacuolar protein sorting-associated protein 41 homolog
VPS41	P49754	82	107	1	854	Chain	ID=PRO_0000212823;Note=Vacuolar protein sorting-associated protein 41 homolog
VPS41	P49754	786	801	791	839	Zinc finger	Note=RING-type%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175
VPS41	P49754	376	395	1	540	Region	Note=Interaction with ARL8B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25908847;Dbxref=PMID:25908847
VPS41	P49754	82	107	1	540	Region	Note=Interaction with ARL8B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25908847;Dbxref=PMID:25908847
VPS41	P49754	82	107	83	107	Alternative sequence	ID=VSP_054169;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS36	Q86VN1	258	280	1	386	Chain	ID=PRO_0000215222;Note=Vacuolar protein-sorting-associated protein 36
VPS36	Q86VN1	187	213	1	386	Chain	ID=PRO_0000215222;Note=Vacuolar protein-sorting-associated protein 36
VPS36	Q86VN1	176	187	1	386	Chain	ID=PRO_0000215222;Note=Vacuolar protein-sorting-associated protein 36
VPS36	Q86VN1	147	176	1	386	Chain	ID=PRO_0000215222;Note=Vacuolar protein-sorting-associated protein 36
VPS36	Q86VN1	117	147	1	386	Chain	ID=PRO_0000215222;Note=Vacuolar protein-sorting-associated protein 36
VPS36	Q86VN1	117	147	105	138	Domain	Note=GLUE C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00828
VPS36	Q86VN1	176	187	160	185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
VPS36	Q86VN1	147	176	160	185	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
VPS36	Q86VN1	176	187	185	185	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS36	Q86VN1	117	147	115	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HTH
VPS36	Q86VN1	187	213	175	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	176	187	175	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	147	176	175	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	187	213	197	199	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	258	280	240	259	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	258	280	262	265	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	258	280	266	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VPS36	Q86VN1	258	280	278	280	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CUQ
VSIG1	Q86XK7	189	229	22	387	Chain	ID=PRO_0000313573;Note=V-set and immunoglobulin domain-containing protein 1
VSIG1	Q86XK7	189	229	22	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG1	Q86XK7	189	229	140	227	Domain	Note=Ig-like C2-type
VSIG1	Q86XK7	189	229	200	200	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG1	Q86XK7	189	229	219	219	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG1	Q86XK7	189	229	161	211	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VPS51	Q9UID3	119	168	2	782	Chain	ID=PRO_0000089831;Note=Vacuolar protein sorting-associated protein 51 homolog
VPS51	Q9UID3	553	626	2	782	Chain	ID=PRO_0000089831;Note=Vacuolar protein sorting-associated protein 51 homolog
VPS51	Q9UID3	119	168	116	147	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
VPS51	Q9UID3	119	168	1	124	Alternative sequence	ID=VSP_014700;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874
VSIG10L	Q86VR7	768	806	28	867	Chain	ID=PRO_0000395117;Note=V-set and immunoglobulin domain-containing protein 10-like
VSIG10L	Q86VR7	669	768	28	867	Chain	ID=PRO_0000395117;Note=V-set and immunoglobulin domain-containing protein 10-like
VSIG10L	Q86VR7	768	806	28	776	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10L	Q86VR7	669	768	28	776	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10L	Q86VR7	768	806	777	797	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10L	Q86VR7	768	806	798	867	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VSIG10L	Q86VR7	768	806	769	769	Natural variant	ID=VAR_080078;Note=Found in esophageal adenocarcinoma%3B somatic mutation%3B unknown pathological significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27467440;Dbxref=dbSNP:rs377207472,PMID:27467440
VWA8	A3KMH1	217	272	29	1905	Chain	ID=PRO_0000342685;Note=von Willebrand factor A domain-containing protein 8;Ontology_term=ECO:0000255;evidence=ECO:0000255
VWA8	A3KMH1	161	217	29	1905	Chain	ID=PRO_0000342685;Note=von Willebrand factor A domain-containing protein 8;Ontology_term=ECO:0000255;evidence=ECO:0000255
VWA8	A3KMH1	161	217	165	165	Natural variant	ID=VAR_044337;Note=R->H;Dbxref=dbSNP:rs9562362
UHRF1BP1	Q6BDS2	69	82	1	1440	Chain	ID=PRO_0000065723;Note=UHRF1-binding protein 1
UHRF1BP1	Q6BDS2	344	373	1	1440	Chain	ID=PRO_0000065723;Note=UHRF1-binding protein 1
USP9Y	O00507	789	858	1	2555	Chain	ID=PRO_0000080690;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
USP9Y	O00507	1092	1124	1	2555	Chain	ID=PRO_0000080690;Note=Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
UST	Q9Y2C2	97	149	1	406	Chain	ID=PRO_0000207681;Note=Uronyl 2-sulfotransferase
UST	Q9Y2C2	97	149	71	406	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
UST	Q9Y2C2	97	149	140	140	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLT4	P35916	1032	1073	25	1363	Chain	ID=PRO_0000016776;Note=Vascular endothelial growth factor receptor 3
FLT4	P35916	1032	1073	797	1363	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
FLT4	P35916	1032	1073	845	1173	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
FLT4	P35916	1032	1073	1037	1037	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
FLT4	P35916	1032	1073	1063	1063	Modified residue	Note=Phosphotyrosine%3B by autocatalysis and SRC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16076871,ECO:0000269|PubMed:20431062;Dbxref=PMID:16076871,PMID:20431062
FLT4	P35916	1032	1073	1068	1068	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16076871,ECO:0000269|PubMed:20431062;Dbxref=PMID:16076871,PMID:20431062
FLT4	P35916	1032	1073	766	1298	Alternative sequence	ID=VSP_041994;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464
FLT4	P35916	1032	1073	1035	1035	Natural variant	ID=VAR_074047;Note=Probable disease-associated mutation found in sporadic congenital lymphedema%3B de novo mutation. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16965327;Dbxref=PMID:16965327
FLT4	P35916	1032	1073	1035	1035	Natural variant	ID=VAR_018412;Note=In LMPH1A%3B loss of kinase activity. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10856194;Dbxref=dbSNP:rs121909653,PMID:10856194
FLT4	P35916	1032	1073	1041	1041	Natural variant	ID=VAR_018413;Note=In LMPH1A%3B loss of kinase activity. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10835628,ECO:0000269|PubMed:12881528;Dbxref=dbSNP:rs121909650,PMID:10835628,PMID:12881528
FLT4	P35916	1032	1073	1044	1044	Natural variant	ID=VAR_018414;Note=In LMPH1A%3B loss of kinase activity. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10835628;Dbxref=dbSNP:rs121909651,PMID:10835628
FLT4	P35916	1032	1073	1049	1049	Natural variant	ID=VAR_042067;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56310180,PMID:17344846
FLT4	P35916	1032	1073	1063	1063	Mutagenesis	Note=Loss of phosphorylation site. No effect on stimulation of cell proliferation and cell migration. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16076871,ECO:0000269|PubMed:20431062;Dbxref=PMID:16076871,PMID:20431062
FLT4	P35916	1032	1073	1068	1068	Mutagenesis	Note=Global loss of autophosphorylation. Abolishes stimulation of cell proliferation and cell migration. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16076871,ECO:0000269|PubMed:20431062;Dbxref=PMID:16076871,PMID:20431062
VIL1	P09327	401	447	2	827	Chain	ID=PRO_0000218727;Note=Villin-1
VIL1	P09327	500	560	2	827	Chain	ID=PRO_0000218727;Note=Villin-1
VIL1	P09327	720	743	2	827	Chain	ID=PRO_0000218727;Note=Villin-1
VIL1	P09327	743	790	2	827	Chain	ID=PRO_0000218727;Note=Villin-1
VIL1	P09327	401	447	407	457	Repeat	Note=Gelsolin-like 4
VIL1	P09327	500	560	528	568	Repeat	Note=Gelsolin-like 5
VIL1	P09327	743	790	761	827	Domain	Note=HP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00595
VIL1	P09327	401	447	2	734	Region	Note=Core
VIL1	P09327	500	560	2	734	Region	Note=Core
VIL1	P09327	720	743	2	734	Region	Note=Core
VIL1	P09327	720	743	735	827	Region	Note=Headpiece
VIL1	P09327	743	790	735	827	Region	Note=Headpiece
VIL1	P09327	720	743	735	735	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62468
VIL1	P09327	401	447	368	421	Alternative sequence	ID=VSP_054436;Note=In isoform 2. AKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHF->GEGQAGAVREPGSRSWARRATWSTTHPPSLTCIFNEDFYAGSGLVLADGDVDKL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VIL1	P09327	401	447	422	827	Alternative sequence	ID=VSP_054437;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VIL1	P09327	500	560	422	827	Alternative sequence	ID=VSP_054437;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VIL1	P09327	720	743	422	827	Alternative sequence	ID=VSP_054437;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VIL1	P09327	743	790	422	827	Alternative sequence	ID=VSP_054437;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VIL1	P09327	500	560	555	555	Mutagenesis	Note=Complete loss of phosphorylation and interaction with PLCG1%2C does not reduce lamellipodium or ruffle localization%2C inhibits cell migration%3B when associated with F-46%3B F-60%3B F-81%3B F-256%3B F-286%3B F-324%3B F-461%3B F-604 and F-725. Inhibits interaction with PLCG1 and lamellipodia localization%3B when associated with F-286%3B F-324%3B F-461%3B F-604 and F-725. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16921170,ECO:0000269|PubMed:17229814,ECO:0000269|PubMed:18054784;Dbxref=PMID:16921170,PMID:17229814,PMID:18054784
VIL1	P09327	720	743	725	725	Mutagenesis	Note=Complete loss of phosphorylation and interaction with PLCG1%2C does not reduce lamellipodium or ruffle localization%2C inhibits cell migration%3B when associated with F-46%3B F-60%3B F-81%3B F-256%3B F-286%3B F-324%3B F-461%3B F-555 and F-604. Inhibits interaction with PLCG1 and lamellipodia localization%3B when associated with F-286%3B F-324%3B F-461%3B F-555 and F-604. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16921170,ECO:0000269|PubMed:17229814,ECO:0000269|PubMed:18054784;Dbxref=PMID:16921170,PMID:17229814,PMID:18054784
VIL1	P09327	720	743	732	732	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
VIL1	P09327	720	743	732	732	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
VIL1	P09327	720	743	735	735	Sequence conflict	Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
VCL	P18206	624	674	1	1134	Chain	ID=PRO_0000064252;Note=Vinculin
VCL	P18206	915	983	1	1134	Chain	ID=PRO_0000064252;Note=Vinculin
VCL	P18206	624	674	1	835	Region	Note=N-terminal globular head;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484056;Dbxref=PMID:20484056
VCL	P18206	915	983	879	1134	Region	Note=C-terminal tail;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20484056;Dbxref=PMID:20484056
VCL	P18206	624	674	672	672	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VCL	P18206	624	674	296	1134	Alternative sequence	ID=VSP_011859;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
VCL	P18206	915	983	296	1134	Alternative sequence	ID=VSP_011859;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
VCL	P18206	915	983	916	983	Alternative sequence	ID=VSP_006731;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2116004;Dbxref=PMID:15489334,PMID:2116004
VCL	P18206	915	983	934	934	Natural variant	ID=VAR_035102;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16236538;Dbxref=dbSNP:rs16931179,PMID:16236538
VCL	P18206	915	983	943	943	Natural variant	ID=VAR_035103;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16236538;Dbxref=dbSNP:rs71579375,PMID:16236538
VCL	P18206	915	983	954	954	Natural variant	ID=VAR_035104;Note=In CMD1W. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11815424;Dbxref=PMID:11815424
VCL	P18206	915	983	975	975	Natural variant	ID=VAR_035105;Note=In CMD1W%3B significantly alters metavinculin-mediated cross-linking of actin filaments. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11815424,ECO:0000269|PubMed:16236538;Dbxref=dbSNP:rs121917776,PMID:11815424,PMID:16236538
VCL	P18206	624	674	620	624	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TR2
VCL	P18206	624	674	625	650	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TR2
VCL	P18206	624	674	655	681	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1TR2
VCL	P18206	915	983	964	977	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3MYI
VWA5A	O00534	453	508	1	786	Chain	ID=PRO_0000084411;Note=von Willebrand factor A domain-containing protein 5A
VWA5A	O00534	453	508	1	786	Chain	ID=PRO_0000084411;Note=von Willebrand factor A domain-containing protein 5A
VWA5A	O00534	453	508	281	462	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
VWA5A	O00534	453	508	281	462	Domain	Note=VWFA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00219
VWA5A	O00534	453	508	267	786	Alternative sequence	ID=VSP_013365;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14504409;Dbxref=PMID:14504409
VWA5A	O00534	453	508	267	786	Alternative sequence	ID=VSP_013365;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14504409;Dbxref=PMID:14504409
VWA5A	O00534	453	508	416	786	Alternative sequence	ID=VSP_013366;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14504409,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14504409,PMID:15489334
VWA5A	O00534	453	508	416	786	Alternative sequence	ID=VSP_013366;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14504409,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:14504409,PMID:15489334
VWA5A	O00534	453	508	427	786	Alternative sequence	ID=VSP_013368;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14504409;Dbxref=PMID:14504409
VWA5A	O00534	453	508	427	786	Alternative sequence	ID=VSP_013368;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14504409;Dbxref=PMID:14504409
VWA5A	O00534	453	508	499	499	Natural variant	ID=VAR_014193;Note=S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9417908;Dbxref=dbSNP:rs2276054,PMID:9417908
VWA5A	O00534	453	508	499	499	Natural variant	ID=VAR_014193;Note=S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9417908;Dbxref=dbSNP:rs2276054,PMID:9417908
VWA5A	O00534	453	508	506	506	Natural variant	ID=VAR_014194;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9417908;Dbxref=dbSNP:rs2276053,PMID:9417908
VWA5A	O00534	453	508	506	506	Natural variant	ID=VAR_014194;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9417908;Dbxref=dbSNP:rs2276053,PMID:9417908
SLC18A1	P54219	403	443	1	525	Chain	ID=PRO_0000127510;Note=Chromaffin granule amine transporter
SLC18A1	P54219	306	338	1	525	Chain	ID=PRO_0000127510;Note=Chromaffin granule amine transporter
SLC18A1	P54219	182	210	1	525	Chain	ID=PRO_0000127510;Note=Chromaffin granule amine transporter
SLC18A1	P54219	403	443	1	525	Chain	ID=PRO_0000127510;Note=Chromaffin granule amine transporter
SLC18A1	P54219	306	338	1	525	Chain	ID=PRO_0000127510;Note=Chromaffin granule amine transporter
SLC18A1	P54219	182	210	1	525	Chain	ID=PRO_0000127510;Note=Chromaffin granule amine transporter
SLC18A1	P54219	182	210	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	182	210	168	188	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	182	210	189	197	Topological domain	Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	182	210	189	197	Topological domain	Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	182	210	198	218	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	182	210	198	218	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	300	319	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	300	319	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	320	335	Topological domain	Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	320	335	Topological domain	Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	336	360	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	336	360	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	403	443	398	418	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	403	443	398	418	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	403	443	419	422	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	403	443	419	422	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	403	443	423	443	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	403	443	423	443	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A1	P54219	306	338	307	338	Alternative sequence	ID=VSP_046304;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC18A1	P54219	306	338	307	338	Alternative sequence	ID=VSP_046304;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SLC18A1	P54219	182	210	202	202	Natural variant	ID=VAR_029151;Note=I->T;Dbxref=dbSNP:rs17222120
SLC18A1	P54219	182	210	202	202	Natural variant	ID=VAR_029151;Note=I->T;Dbxref=dbSNP:rs17222120
ATP6V0A1	Q93050	98	141	1	837	Chain	ID=PRO_0000119211;Note=V-type proton ATPase 116 kDa subunit a isoform 1
ATP6V0A1	Q93050	668	704	1	837	Chain	ID=PRO_0000119211;Note=V-type proton ATPase 116 kDa subunit a isoform 1
ATP6V0A1	Q93050	98	141	1	388	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A1	Q93050	668	704	659	724	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ATP6V0A1	Q93050	98	141	141	141	Alternative sequence	ID=VSP_043532;Note=In isoform 3. E->EAELHHQQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VPS45	Q9NRW7	123	146	1	570	Chain	ID=PRO_0000206312;Note=Vacuolar protein sorting-associated protein 45
VPS45	Q9NRW7	146	192	1	570	Chain	ID=PRO_0000206312;Note=Vacuolar protein sorting-associated protein 45
VPS45	Q9NRW7	229	274	1	570	Chain	ID=PRO_0000206312;Note=Vacuolar protein sorting-associated protein 45
VPS45	Q9NRW7	312	368	1	570	Chain	ID=PRO_0000206312;Note=Vacuolar protein sorting-associated protein 45
VPS45	Q9NRW7	368	421	1	570	Chain	ID=PRO_0000206312;Note=Vacuolar protein sorting-associated protein 45
VPS45	Q9NRW7	421	457	1	570	Chain	ID=PRO_0000206312;Note=Vacuolar protein sorting-associated protein 45
VPS45	Q9NRW7	421	457	441	441	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08700
VPS45	Q9NRW7	123	146	124	192	Alternative sequence	ID=VSP_056740;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	146	192	124	192	Alternative sequence	ID=VSP_056740;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	229	274	238	238	Natural variant	ID=VAR_069866;Note=In SCN5. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23738510;Dbxref=dbSNP:rs782269909,PMID:23738510
VPS45	Q9NRW7	146	192	163	163	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	146	192	188	188	Sequence conflict	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	229	274	241	241	Sequence conflict	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	368	421	370	370	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	368	421	385	385	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	368	421	407	408	Sequence conflict	Note=MM->IV;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	368	421	412	412	Sequence conflict	Note=N->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	368	421	412	412	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS45	Q9NRW7	368	421	416	416	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
USPL1	Q5W0Q7	289	327	1	1092	Chain	ID=PRO_0000279526;Note=SUMO-specific isopeptidase USPL1
USPL1	Q5W0Q7	371	412	1	1092	Chain	ID=PRO_0000279526;Note=SUMO-specific isopeptidase USPL1
USPL1	Q5W0Q7	289	327	227	500	Domain	Note=USP
USPL1	Q5W0Q7	371	412	227	500	Domain	Note=USP
USPL1	Q5W0Q7	289	327	236	495	Region	Note=SUMO-binding
USPL1	Q5W0Q7	371	412	236	495	Region	Note=SUMO-binding
USPL1	Q5W0Q7	289	327	1	329	Alternative sequence	ID=VSP_023479;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
USPL1	Q5W0Q7	371	412	384	384	Natural variant	ID=VAR_030917;Note=P->S;Dbxref=dbSNP:rs3742303
VDAC2	P45880	134	209	2	294	Chain	ID=PRO_0000050505;Note=Voltage-dependent anion-selective channel protein 2
VDAC2	P45880	134	209	134	141	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC2	P45880	134	209	148	156	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC2	P45880	134	209	161	169	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC2	P45880	134	209	174	186	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC2	P45880	134	209	189	196	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC2	P45880	134	209	200	209	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC2	P45880	134	209	172	172	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796
VEZT	Q9HBM0	56	86	1	779	Chain	ID=PRO_0000065783;Note=Vezatin
VEZT	Q9HBM0	56	86	57	79	Alternative sequence	ID=VSP_040853;Note=In isoform 6. QGILLKVAETIKSWIFFSQCNKK->YLGYSNHSMNINCTYWHAQGMGY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VEZT	Q9HBM0	56	86	57	65	Alternative sequence	ID=VSP_040854;Note=In isoform 5. QGILLKVAE->GSLSAICLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VEZT	Q9HBM0	56	86	66	779	Alternative sequence	ID=VSP_040855;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VEZT	Q9HBM0	56	86	80	779	Alternative sequence	ID=VSP_040856;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
KDR	P35968	548	662	20	1356	Chain	ID=PRO_0000016771;Note=Vascular endothelial growth factor receptor 2
KDR	P35968	548	662	20	764	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDR	P35968	548	662	421	548	Domain	Note=Ig-like C2-type 5
KDR	P35968	548	662	551	660	Domain	Note=Ig-like C2-type 6
KDR	P35968	548	662	580	580	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDR	P35968	548	662	613	613	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDR	P35968	548	662	619	619	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDR	P35968	548	662	631	631	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
KDR	P35968	548	662	571	642	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
KDR	P35968	548	662	537	548	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OYJ
VGLL1	Q99990	71	211	1	258	Chain	ID=PRO_0000191347;Note=Transcription cofactor vestigial-like protein 1
VGLL2	Q8N8G2	130	304	1	317	Chain	ID=PRO_0000191349;Note=Transcription cofactor vestigial-like protein 2
VGLL2	Q8N8G2	130	304	131	304	Alternative sequence	ID=VSP_032166;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12376544,ECO:0000303|PubMed:15489334;Dbxref=PMID:12376544,PMID:15489334
SLC17A7	Q9P2U7	383	420	1	560	Chain	ID=PRO_0000331611;Note=Vesicular glutamate transporter 1
SLC17A7	Q9P2U7	383	420	379	399	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A7	Q9P2U7	383	420	400	401	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC17A7	Q9P2U7	383	420	402	422	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
VILL	O15195	281	314	1	856	Chain	ID=PRO_0000218738;Note=Villin-like protein
VILL	O15195	394	440	1	856	Chain	ID=PRO_0000218738;Note=Villin-like protein
VILL	O15195	493	553	1	856	Chain	ID=PRO_0000218738;Note=Villin-like protein
VILL	O15195	281	314	1	856	Chain	ID=PRO_0000218738;Note=Villin-like protein
VILL	O15195	394	440	1	856	Chain	ID=PRO_0000218738;Note=Villin-like protein
VILL	O15195	493	553	1	856	Chain	ID=PRO_0000218738;Note=Villin-like protein
VILL	O15195	281	314	263	307	Repeat	Note=Gelsolin-like 3
VILL	O15195	281	314	263	307	Repeat	Note=Gelsolin-like 3
VILL	O15195	394	440	401	450	Repeat	Note=Gelsolin-like 4
VILL	O15195	394	440	401	450	Repeat	Note=Gelsolin-like 4
VILL	O15195	493	553	521	561	Repeat	Note=Gelsolin-like 5
VILL	O15195	493	553	521	561	Repeat	Note=Gelsolin-like 5
SLC18A2	Q05940	233	263	1	514	Chain	ID=PRO_0000127514;Note=Synaptic vesicular amine transporter
SLC18A2	Q05940	233	263	220	242	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A2	Q05940	233	263	243	248	Topological domain	Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A2	Q05940	233	263	249	271	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
SLC18A2	Q05940	233	263	117	324	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009896;Dbxref=PMID:12009896
SLC18A2	Q05940	233	263	210	514	Alternative sequence	ID=VSP_057152;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VPS26A	O75436	1	51	1	327	Chain	ID=PRO_0000073007;Note=Vacuolar protein sorting-associated protein 26A
VPS26A	O75436	129	183	1	327	Chain	ID=PRO_0000073007;Note=Vacuolar protein sorting-associated protein 26A
VPS26A	O75436	219	242	1	327	Chain	ID=PRO_0000073007;Note=Vacuolar protein sorting-associated protein 26A
VPS26A	O75436	1	51	1	327	Chain	ID=PRO_0000073007;Note=Vacuolar protein sorting-associated protein 26A
VPS26A	O75436	129	183	1	327	Chain	ID=PRO_0000073007;Note=Vacuolar protein sorting-associated protein 26A
VPS26A	O75436	219	242	1	327	Chain	ID=PRO_0000073007;Note=Vacuolar protein sorting-associated protein 26A
VPS26A	O75436	219	242	235	236	Mutagenesis	Note=Abolishes interaction with VPS35 and endosomal subcellular location. IM->DD
VPS26A	O75436	219	242	235	236	Mutagenesis	Note=Abolishes interaction with VPS35 and endosomal subcellular location. IM->DD
VPS26A	O75436	219	242	242	242	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS26A	O75436	219	242	242	242	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
VPS26A	O75436	1	51	7	11	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	7	11	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	12	18	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	12	18	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	21	23	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	21	23	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	26	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	26	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	32	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F0J
VPS26A	O75436	1	51	32	34	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F0J
VPS26A	O75436	1	51	36	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	36	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	48	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	1	51	48	60	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	124	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	124	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	139	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	139	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	143	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	143	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	171	173	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	171	173	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	174	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	174	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	129	183	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	219	242	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	219	242	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	219	242	224	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
VPS26A	O75436	219	242	224	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FAU
ATP6V1C1	P21283	158	190	2	382	Chain	ID=PRO_0000209348;Note=V-type proton ATPase subunit C 1
ATP6V1C1	P21283	191	213	2	382	Chain	ID=PRO_0000209348;Note=V-type proton ATPase subunit C 1
ATP6V1C1	P21283	158	190	2	382	Chain	ID=PRO_0000209348;Note=V-type proton ATPase subunit C 1
ATP6V1C1	P21283	191	213	2	382	Chain	ID=PRO_0000209348;Note=V-type proton ATPase subunit C 1
ATP6V1C2	Q8NEY4	213	243	1	427	Chain	ID=PRO_0000285669;Note=V-type proton ATPase subunit C 2
ATP6V1C2	Q8NEY4	275	321	1	427	Chain	ID=PRO_0000285669;Note=V-type proton ATPase subunit C 2
ATP6V1C2	Q8NEY4	275	321	276	321	Alternative sequence	ID=VSP_024883;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12384298,ECO:0000303|PubMed:15489334;Dbxref=PMID:12384298,PMID:15489334
ATP6V1H	Q9UI12	426	463	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	392	425	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	350	391	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	175	193	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	102	140	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	72	102	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	426	463	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	392	425	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	350	391	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	175	193	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	102	140	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	72	102	1	483	Chain	ID=PRO_0000124193;Note=V-type proton ATPase subunit H
ATP6V1H	Q9UI12	175	193	176	193	Alternative sequence	ID=VSP_012274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ATP6V1H	Q9UI12	175	193	176	193	Alternative sequence	ID=VSP_012274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
ATP6V1H	Q9UI12	102	140	129	129	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATP6V1H	Q9UI12	102	140	129	129	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
VDAC3	Q9Y277	39	90	2	283	Chain	ID=PRO_0000050512;Note=Voltage-dependent anion-selective channel protein 3
VDAC3	Q9Y277	39	90	39	47	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC3	Q9Y277	39	90	54	64	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC3	Q9Y277	39	90	69	76	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC3	Q9Y277	39	90	80	89	Transmembrane	Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250
VDAC3	Q9Y277	39	90	90	90	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
VDAC3	Q9Y277	39	90	53	53	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC3	Q9Y277	39	90	61	61	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951
VDAC3	Q9Y277	39	90	39	39	Alternative sequence	ID=VSP_005079;Note=In isoform 2. V->VM;Ontology_term=ECO:0000305;evidence=ECO:0000305
VAPA	Q9P0L0	112	139	2	249	Chain	ID=PRO_0000213470;Note=Vesicle-associated membrane protein-associated protein A
VAPA	Q9P0L0	139	197	2	249	Chain	ID=PRO_0000213470;Note=Vesicle-associated membrane protein-associated protein A
VAPA	Q9P0L0	112	139	2	227	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VAPA	Q9P0L0	139	197	2	227	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VAPA	Q9P0L0	112	139	14	131	Domain	Note=MSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00132
VAPA	Q9P0L0	139	197	169	205	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
VAPA	Q9P0L0	112	139	125	125	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
VAPA	Q9P0L0	139	197	166	166	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAPA	Q9P0L0	139	197	170	170	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
VAPA	Q9P0L0	112	139	139	139	Alternative sequence	ID=VSP_038648;Note=In isoform 2. L->LGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VAPA	Q9P0L0	139	197	139	139	Alternative sequence	ID=VSP_038648;Note=In isoform 2. L->LGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
VAPA	Q9P0L0	139	197	160	160	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
VAPA	Q9P0L0	112	139	109	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RR3
VAPA	Q9P0L0	112	139	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RR3
VAPA	Q9P0L0	112	139	122	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RR3
VAPB	O95292	105	132	2	243	Chain	ID=PRO_0000213473;Note=Vesicle-associated membrane protein-associated protein B/C
VAPB	O95292	105	132	2	222	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
VAPB	O95292	105	132	7	124	Domain	Note=MSP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00132
VAPB	O95292	105	132	100	243	Alternative sequence	ID=VSP_003278;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9920726;Dbxref=PMID:9920726
VAPB	O95292	105	132	103	106	Sequence conflict	Note=EAVW->DGTR;Ontology_term=ECO:0000305;evidence=ECO:0000305
VAPB	O95292	105	132	104	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKK
VAPB	O95292	105	132	111	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKK
VAPB	O95292	105	132	115	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3IKK
ATP6V1B2	P21281	128	154	1	511	Chain	ID=PRO_0000144626;Note=V-type proton ATPase subunit B%2C brain isoform
ATP6V1B2	P21281	201	235	1	511	Chain	ID=PRO_0000144626;Note=V-type proton ATPase subunit B%2C brain isoform
ATP6V1D	Q9Y5K8	102	117	1	247	Chain	ID=PRO_0000144231;Note=V-type proton ATPase subunit D
VCAM1	P19320	21	113	1	24	Signal peptide	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
VCAM1	P19320	21	113	25	739	Chain	ID=PRO_0000014997;Note=Vascular cell adhesion protein 1
VCAM1	P19320	309	401	25	739	Chain	ID=PRO_0000014997;Note=Vascular cell adhesion protein 1
VCAM1	P19320	508	597	25	739	Chain	ID=PRO_0000014997;Note=Vascular cell adhesion protein 1
VCAM1	P19320	21	113	25	698	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAM1	P19320	309	401	25	698	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAM1	P19320	508	597	25	698	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAM1	P19320	21	113	25	105	Domain	Note=Ig-like C2-type 1
VCAM1	P19320	21	113	109	212	Domain	Note=Ig-like C2-type 2
VCAM1	P19320	309	401	223	309	Domain	Note=Ig-like C2-type 3
VCAM1	P19320	309	401	312	399	Domain	Note=Ig-like C2-type 4
VCAM1	P19320	508	597	511	595	Domain	Note=Ig-like C2-type 6
VCAM1	P19320	309	401	365	365	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAM1	P19320	508	597	531	531	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
VCAM1	P19320	508	597	561	561	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952
VCAM1	P19320	21	113	47	95	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7539925;Dbxref=PMID:7539925
VCAM1	P19320	21	113	52	99	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7539925;Dbxref=PMID:7539925
VCAM1	P19320	309	401	335	383	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VCAM1	P19320	508	597	534	579	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114
VCAM1	P19320	21	113	52	113	Alternative sequence	ID=VSP_044636;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
VCAM1	P19320	309	401	310	402	Alternative sequence	ID=VSP_002580;Note=In isoform 2. EKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYS->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2688898;Dbxref=PMID:2688898
VCAM1	P19320	309	401	318	318	Natural variant	ID=VAR_014309;Note=S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3783611
VCAM1	P19320	309	401	384	384	Natural variant	ID=VAR_014310;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3783612
VCAM1	P19320	21	113	26	38	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	43	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	56	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	77	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	87	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	91	99	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA
VCAM1	P19320	21	113	102	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VCA